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Sample records for joseph m. farley-2 reactor

  1. 75 FR 76052 - Southern Nuclear Operating Company, Inc. Joseph M. Farley Nuclear Plant, Units 1 and 2; Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... environment (75 FR 73135, dated November 29, 2010). This exemption is effective upon issuance. Dated at... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Southern Nuclear Operating Company, Inc. Joseph M. Farley Nuclear Plant, Units 1 and 2;...

  2. Joseph Ames

    NASA Technical Reports Server (NTRS)

    1920-01-01

    Dr. Joseph Sweetman Ames at his desk at the NACA headquarters. Dr. Ames was a founding member of NACA (National Advisory Committee for Aeronautics), appointed by President Woodrow Wilson in 1915. Ames took on NACA's most challenging assignments but mostly represented physics. He chaired the Foreign Service Committee of the newly-founded National Research Council, oversaw the NACA's patent cross-licensing plan that allowed manufacturers to share technologies. Ames expected the NACA to encourage engineering education. He pressed universities to train more aerodynamicists, then structured NACA to give young engineers on-the-job training. Ames gave the NACA a focused vision that was research-based and decided that aerodynamics was the most important field of endeavor. He championed the work of theorists like Max Munk. The world class wind tunnels at Langley Aeronautical laboratory reflected his vision as well as the faith Congress put in him. Ames became chairman of the NACA main committee in 1927. Two years later he accepted the Collier Trophy on behalf on the NACA. He kept the NACA alive when Herbert Hoover tried to eliminate it and transfer its duties to industry. Ames accepted a nomination by Air Minister Hermann Goring to the Deutsche Akademie der Luftfartforschung. Ames then considered it an honor, many Americans did, and was surprised to learn about the massive Nazi investment in aeronautical infrastructure, then six times larger than the NACA. Ames urged the funding for a second laboratory and expansion of the NACA facilities to prepare for war. A stroke in May 1936 paralyzed the right side of his body. He immediately resigned as chairman of the NACA executive committee and in October 1937 he resigned from the NACA main committee. On June 8, 1944 the NACA officially dedicated its new laboratory in Sunnyvale California to Joseph S. Ames. Ames died in 1943, having never stepped foot in the new laboratory that bears his name; the Ames Aeronautical Laboratory

  3. 76 FR 71374 - Joseph Giacchino, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ...); Agostino Carlucci, M.D., 49 FR 33,184, 33,184-85 (1984). Rather, what matters--as DEA has repeatedly held... does business. See Scott Sandarg, DMD, 74 FR 17528 (DEA 2009); David W. Wang, M.D., 72 FR 54297 (DEA 2007); Sheran Arden Yeates, M.D., 71 FR 39130 (DEA 2006); Dominick A. Ricci, M.D., 58 FR 51104...

  4. Jean Baptiste Joseph Fourier

    NASA Astrophysics Data System (ADS)

    Sterken, C.

    2003-03-01

    This paper gives a short account of some key elements in the life of Jean Baptiste Joseph Fourier (1768-1830), specifically his relation to Napoleon Bonaparte. The mathematical approach to Fourier series and the original scepticism by French mathematicians are briefly illustrated.

  5. Joseph Conrad: International Narrator

    ERIC Educational Resources Information Center

    Walker, George

    2004-01-01

    This article discusses the contribution made by Joseph Conrad's fictional writing to our understanding of cultural awareness. Never comfortable with his adopted English culture, Conrad used his experiences in different parts of the world during his career in the merchant navy to explore in his writing aspects of cultural dissonance and cultural…

  6. Combined therapy with m-TOR-dependent and -independent autophagy inducers causes neurotoxicity in a mouse model of Machado-Joseph disease.

    PubMed

    Duarte-Silva, S; Silva-Fernandes, A; Neves-Carvalho, A; Soares-Cunha, C; Teixeira-Castro, A; Maciel, P

    2016-01-28

    A major pathological hallmark in several neurodegenerative disorders, like polyglutamine disorders (polyQ), including Machado-Joseph disease (MJD), is the formation of protein aggregates. MJD is caused by a CAG repeat expansion in the ATXN3 gene, resulting in an abnormal protein, which is prone to misfolding and forms cytoplasmic and nuclear aggregates within neurons, ultimately inducing neurodegeneration. Treatment of proteinopathies with drugs that up-regulate autophagy has shown promising results in models of polyQ diseases. Temsirolimus (CCI-779) inhibits the mammalian target of rapamycin (m-TOR), while lithium chloride (LiCl) acts by inhibiting inositol monophosphatase, both being able to induce autophagy. We have previously shown that chronic treatment with LiCl (10.4 mg/kg) had limited effects in a transgenic MJD mouse model. Also, others have shown that CCI-779 had mild positive effects in a different mouse model of the disease. It has been suggested that the combination of mTOR-dependent and -independent autophagy inducers could be a more effective therapeutic approach. To further explore this avenue toward therapy, we treated CMVMJD135 transgenic mice with a conjugation of CCI-779 and LiCl, both at concentrations known to induce autophagy and not to be toxic. Surprisingly, this combined treatment proved to be deleterious to both wild-type (wt) and transgenic animals, failing to rescue their neurological symptoms and actually exerting neurotoxic effects. These results highlight the possible dangers of manipulating autophagy in the nervous system and suggest that a better understanding of the potential disruption in the autophagy pathway in MJD is required before successful long-term autophagy modulating therapies can be developed. PMID:26601773

  7. Joseph Lister's first operation

    PubMed Central

    Richardson, Ruth; Rhodes, Bryan

    2013-01-01

    Joseph Lister was still a medical student in 1851 when he served as house surgeon at University College Hospital, London, under John Erichsen. Here we report the first major operation that Lister accomplished, hitherto apparently missed by biographers. We chart his exemplary dealings with an emergency case of eviscerating stab wound in a woman brought to casualty at night, when he had been in post for less than a month. The case demonstrates Lister's fundamental competence at an early stage in his training. We outline the context of debate and controversy over the repair of lacerated gut at the time, and argue that Lister's period at University College London was profoundly formative.

  8. 6. Historic American Buildings Survey Joseph Hill, Photographer April 1, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey Joseph Hill, Photographer April 1, 1936 MANTEL 1352 W. Washington Blvd., Chicago - Chicago Ironwork, William M. Strong Estate (Cast Iron House & Gate), 1352 West Washington Boulevard, Chicago, Cook County, IL

  9. 4. Historic American Buildings Survey Joseph Hill, Photographer April 5, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey Joseph Hill, Photographer April 5, 1936 INRON WINDOW GRILL, 1352 W. WASHINGTON ST. CHICAGO - Chicago Ironwork, William M. Strong Estate (Cast Iron House & Gate), 1352 West Washington Boulevard, Chicago, Cook County, IL

  10. 2. Historic American Buildings Survey Joseph Hill, Photographer May 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Joseph Hill, Photographer May 10, 1936 CAST IRON GATE AT 1352 W. Washington Blvd., Chicago - Chicago Ironwork, William M. Strong Estate (Cast Iron House & Gate), 1352 West Washington Boulevard, Chicago, Cook County, IL

  11. Joseph Priestley's Legacy in America.

    ERIC Educational Resources Information Center

    McMeekin, Dorothy

    2001-01-01

    Discusses the life and work of Joseph Priestley, a scientist of the late eighteenth century who was famous for his work in both Europe and America. Includes a description of the Joseph Priestley house, a museum containing some of his scientific equipment and exhibitions relating to his work. (MM)

  12. PERSPECTIVE VIEW OF THE FIRST BANK OF JOSEPH, LOCATED BETWEEN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PERSPECTIVE VIEW OF THE FIRST BANK OF JOSEPH, LOCATED BETWEEN JOSEPH AND SECOND AVENUE ON MAIN STREET. VIEW LOOKING SOUTHEAST. - Joseph Main Street, Between Joseph & Second Avenues, Joseph, Wallowa County, OR

  13. Joseph Henry and Astronomy

    NASA Astrophysics Data System (ADS)

    Rothenberg, Marc

    2016-01-01

    Joseph Henry (1797-1878) is best known for his work in electromagnetism and as the first secretary of the Smithsonian Institution. But he was also a pioneer solar physicist, an early advocate of US participation in astrophysics, and a facilitator of international cooperation in astronomy. This paper will briefly trace his role in the development of the US astronomical community from the time he taught astronomy at Princeton in the 1830s through his death, focusing on failed efforts to persuade US astronomers and patrons of astronomy that the best path for US astronomy should be astrophysics. He thought that the US could make a more significant contribution to astronomy science by striking out on a less travelled path rather than competing with the established European observatories.

  14. [Joseph Babinski: a complex personality].

    PubMed

    Poirier, Jacques

    2007-10-01

    Joseph Babinski (1857-1932), a Paris hospital neurologist known for the discovery of his eponymous sign, was a highly complex personality. He was known as a handsome but silent "blue-eyed giant". His parents left Poland for Paris after the insurrection of 1848. Joseph and his elder brother Henri (1855-1931) were born in Paris and were therefore French, but they remained devoted to Poland. Joseph suffered from excruciating self-doubt and was meticulous. He was a reasoner and a righter of wrongs. Henri, who trained as a civil engineer at the French National School of Mines, prospected mineral, gold and diamond deposits in various countries. On his return to France at the end of the century, he wrote, under the pseudonym Ali-Bab, a monumental cookbook called "Gastronomie pratique", which was widely acclaimed Joseph and Henri, both unmarried, lived together and formed an inseparable couple. Joseph Babinski had no religious, political or ideological commitments. Some areas of his private life still remain rather shadowy. PMID:18447056

  15. PERSPECTIVE VIEW OF THE FIRST BANK OF JOSEPH, LOCATED AT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PERSPECTIVE VIEW OF THE FIRST BANK OF JOSEPH, LOCATED AT THE NORTHEAST CORNER OF SECOND AND MAIN, VIEW LOOKING NORTHEAST. - Joseph Main Street, Between Joseph & Second Avenues, Joseph, Wallowa County, OR

  16. University Reactor Conversion Lessons Learned Workshop for Texas A&M University Nuclear Science Center Reactor

    SciTech Connect

    Eric C. Woolstenhulme; Dana M. Meyer

    2007-04-01

    The objectives of this meeting were to capture the observations, insights, issues, concerns, and ideas of those involved in the Texas A&M University Nuclear Science Center (TAMU NSC) TRIGA Reactor Conversion so that future efforts can be conducted with greater effectiveness, efficiency, and with fewer challenges. This workshop was held in conjunction with a similar workshop for the University of Florida Reactor Conversion. Some of the generic lessons from that workshop are included in this report for completeness.

  17. ASK Talks With Joseph Rothenberg

    NASA Technical Reports Server (NTRS)

    Rothenberg, Joseph

    2002-01-01

    Recently retired NASA administrator Joseph Rothenberg reflects on project management during the Apollo era at the start of his career, as well as the history of, and changes in, project management over his years at NASA. He concludes by describing what he sees as NASA's most important needs in the near future.

  18. UWTOR-M, a stellarator power reactor utilizing modular coils

    NASA Astrophysics Data System (ADS)

    Sviatoslavsky, I. N.; Vansciver, S. W.; Kulcinski, G. I.

    1981-10-01

    The parametric considerations which led to the UWTOR-M reference design point are described. The design has 18 twisted coils utilizing a multipolarity of 3, a major radius of 24 m, a coil radius of 4.77 m and a plasma aspect ratio of 14. An assumed (ALPHA) of 5% was used. This configuration leads to a rotational transform on the edge of 1.125 giving favorable plasma physics conditions. The natural stellarator divertor is used for impurity control in conjunction with innovative high performance divertor targets. A unique blanket design which minimizes tritium inventory in the reactor is proposed. A scheme for servicing the first wall/blanket and other reactor components is described.

  19. Joseph Hooker: a philosophical botanist.

    PubMed

    Endersby, Jim

    2008-06-01

    The nineteenth-century British botanist, Joseph Dalton Hooker,was one of the people whose career became a model for that of the modern,professional scientist.However,he preferred to refer to himself as a philosophical botanist, rather than a professional. This paper explores the reasons for this choice,and analyses Hooker's imperial approach to plant classification, the consequences of which are still with us. PMID:18535350

  20. The Birth of Joseph Gabriel

    PubMed Central

    Cantine, Anne Touhill

    2013-01-01

    In this column, a mother shares the story of the birth of her first child. With confidence in the process of birth and in her ability to give birth, and with the support, confidence, and encouragement of her mother and sisters, Anne manages to cope with strong contractions through a busy day. Finally, her husband realizes how fast labor is progressing. Baby Joseph was born less than 2 hours after arrival at the hospital. PMID:24868130

  1. 1. Historic American Buildings Survey Joseph Hill's Photograph Copy of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill's Photograph Copy of Original Photograph May5, 1936 SOUTH ELEVATION 1352 W.WASHINGTON BLVD. -1362 CHICAGO, ILLINOIS. - Chicago Ironwork, William M. Strong Estate (Cast Iron House & Gate), 1352 West Washington Boulevard, Chicago, Cook County, IL

  2. Jay L. King, Joseph D. Huxman, and Orion D. Billeter Assist Pilot Milt Thompson into the M2-F2 Attac

    NASA Technical Reports Server (NTRS)

    1966-01-01

    NASA research pilot Milt Thompson is helped into the cockpit of the M2-F2 lifting body research aircraft at NASA's Flight Research Center (now the Dryden Flight Research Center). The M2-F2 is attached to a wing pylon under the wing of NASA's B-52 mothership. The flight was a captive flight with the pilot on-board. Milt Thompson flew in the lifting body throughout the flight, but it was never dropped from the mothership. NASA B-52, Tail Number 008, is an air launch carrier aircraft, 'mothership,' as well as a research aircraft platform that has been used on a variety of research projects. The aircraft, a 'B' model built in 1952 and first flown on June 11, 1955, is the oldest B-52 in flying status and has been used on some of the most significant research projects in aerospace history. Some of the significant projects supported by B-52 008 include the X-15, the lifting bodies, HiMAT (highly maneuverable aircraft technology), Pegasus, validation of parachute systems developed for the space shuttle program (solid-rocket-booster recovery system and the orbiter drag chute system), and the X-38. The B-52 served as the launch vehicle on 106 X-15 flights and flew a total of 159 captive-carry and launch missions in support of that program from June 1959 to October 1968. Information gained from the highly successful X-15 program contributed to the Mercury, Gemini, and Apollo human spaceflight programs as well as space shuttle development. Between 1966 and 1975, the B-52 served as the launch aircraft for 127 of the 144 wingless lifting body flights. In the 1970s and 1980s, the B-52 was the launch aircraft for several aircraft at what is now the Dryden Flight Research Center, Edwards, California, to study spin-stall, high-angle-of attack, and maneuvering characteristics. These included the 3/8-scale F-15/spin research vehicle (SRV), the HiMAT (Highly Maneuverable Aircraft Technology) research vehicle, and the DAST (drones for aerodynamic and structural testing). The aircraft

  3. Joseph Priestley and the Psychology of Style.

    ERIC Educational Resources Information Center

    Moran, Michael G.

    Joseph Priestley, in his "A Course of Lectures on Oratory and Criticism," developed a psychological theory of style. The "Course" covers three main topics: traditional rhetorical arts of invention, arrangement, and style. Borrowing from the ideas of David Hartley, the association psychologist; Joseph Addison, the aesthetician; and Adam Smith, the…

  4. 75 FR 15430 - Chief Joseph Hatchery Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ... Bonneville Power Administration Chief Joseph Hatchery Program AGENCY: Bonneville Power Administration (BPA... announces the availability of the ROD to implement the proposed action identified in BPA's Chief Joseph Hatchery Program Environmental Impact Statement (DOE/EIS-0384, November 2009). BPA has decided to fund...

  5. Astronaut Joseph Kerwin strapped into sleep restraint in crew quarters

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot, is photographed strapped into the sleep restraint in the crew quarters of the Orbital Workshop of the Skylab 1 and 2 space station cluster in Earth orbit. Kerwin is wearing the special cap which contains biomedical instrumentation for the M133 Sleep Monitoring Experiment. The purpose of the M133 experiment is to evaluate quantity and quality of sleep during prolonged space flight by the analysis of electroencephalographic (EEG) and electrooculographic (EOG) activity.

  6. Joseph Maxwell on mediumistic personifications.

    PubMed

    Alvarado, Carlos S

    2016-09-01

    The study of mediumship received much impetus from the work of psychical researchers. This included ideas about the phenomena of personation, or changes in attitudes, dispositions and behaviours shown by some mediums that supposedly indicated discarnate action. The aim of this Classic Text is to reprint passages about this topic from the writings of French psychical researcher Joseph Maxwell (1858-1938), which were part of the contributions of some psychical researchers to reconceptualize the manifestations in psychological terms. Maxwell suggested these changes in mediums were a production of their subconscious mind. His ideas are a reflection of previous theorization about secondary personalities and a particular example of the contributions of psychical researchers to understand the psychology of mediumship. PMID:27473729

  7. Remembering Joseph Mayo and His Contributions to Animal Science | Poster

    Cancer.gov

    By Carolynne Keenan, Guest Writer In the 1990s, when Joseph Mayo, D.V.M, ran out of gas leading coworkers home from a meeting in Bethesda, he pulled over to the side of the road on I-270 and waited for help. He didn’t have to wait long; within a few minutes a passing motorist took pity on the group of scientists and offered them a lift back to Fort Detrick.

  8. Astronaut Joseph Kerwin takes blood sample from Astronaut Charles Conrad

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Scientist-Astronaut Joseph P. Kerwin (right), Skylab 2 science pilot and a doctor of medicine, takes a blood sample from Astronaut Charles Conrad Jr., Sylab 2 commander, as seen in this reproduction taken from a color television transmission made by a TV camera aboard the Skylab 1 and 2 space station cluster in Earth orbit. The blood sampling was part of the Skylab Hematology and Immunology Experiment M110 series.

  9. Joseph Henry and the Telegraph

    NASA Astrophysics Data System (ADS)

    Hochfelder, David

    1997-04-01

    Morse's telegraph rested upon three scientific advances which occured between 1800 and 1830: the development of battery technology, the formulation of laws governing the behavior of electrical components in circuits, and the discovery of electromagnetic phenomena. Joseph Henry was crucial to the development of the early telegraph. His work on electromagnetism made it possible for the electric current to manifest itself as useful mechanical work. Henry developed electromagnets of sufficient lifting power, but which drew relatively small currents; these magnets were the heart of Morse's telegraph receiver. Morse also used electromagnets as relays, which allowed him to transmit signals over great distances. Morse often acknowledged his debt to Henry, and the two enjoyed a cordial working relationship until the mid-1840s. But during the bitter and protracted litigation over Morse's patent, Henry testified (unwillingly, he claimed) against the inventor. This began a lifelong quarrel between the two men, the specifics of which were tedious and petty. In general terms, however, their conflict arose over different notions regarding scientific discovery and technological innovation.

  10. Joseph Beuys: trauma and catharsis.

    PubMed

    Ottomann, C; Stollwerck, P L; Maier, H; Gatty, I; Muehlberger, T

    2010-12-01

    Joseph Beuys was one of the most significant artists of the 20th century. He was a gunner and radio operator in the German Air Force during World War II, and was severely injured several times. In March 1943 he had a life-changing experience after the dive bomber he was assigned to crashed in the Crimean peninsula. This trauma influenced Beuys' entire artistic career, and is known in art history as the 'Tartar Legend' or 'Tartar Myth'. Profoundly affected by the crash, the severe trauma, the near-death experience and his rescue, which he perceived as a "rebirth", Beuys no longer saw himself, other people or society as a whole in the same way as previously. With his new consciousness, he ignored boundaries and created visions whereby all mankind could experience the healing he had undergone. Beuys did not bring society far enough for the turning point towards "the healing of the world" to be visible, yet today it is important to keep his work alive as a record of his extraordinary strength, which arose from trauma and severe injury, and was carried by a passionate commitment to mankind and to life itself. PMID:21393290

  11. Rethinking Joseph Janangelo's "Joseph Cornell and the Artistry of Composing Persuasive Hypertexts"

    ERIC Educational Resources Information Center

    College Composition and Communication, 2007

    2007-01-01

    This article presents several excerpts from an article written by Joseph Janangelo titled "Joseph Cornell and the Artistry of Composing Persuasive Hypertexts." In his article, Janangelo suggested that Cornell's work and ideas about composing model intelligent ways to composing persuasive nonsequential text. Janangelo also wondered if the use of…

  12. Joseph Conrad's tormented Rescue (fantasy).

    PubMed

    Freedman, William

    2014-02-01

    Joseph Conrad was a notoriously tormented writer for whom the creative act was often a punishment severe enough to drive him into paralyzing depressions that delayed the completion of his novels, sometimes for years. By far the most agonizing of these projects was The Rescue, a novel he began in 1898, abandoned a year later, tried unsuccessfully to continue several times over the next two decades, but was only able to resume in 1918 and to complete, after another tortured two-year struggle, in 1920. An explanation for this incapacity, that is powerfully suggested by the novel's evocative title and perhaps unintentionally ironic subtitle (A Romance of the Shallows) has not yet been explored. Using Freud's 1910 essay on the rescue fantasy, "Contributions to the Psychology of Love: A Special Type of Choice of Object Made by Men," and Emanuel Berman's instructive revision and expansion of the concept in his 2003 American Imago essay, "Ferenczi, Rescue, and Utopia," I argue that a substantial explanation for Conrad's tormented history with The Rescue is ascribable to its quite remarkably faithful treatment of a rescue fantasy with deep and disabling resonance for its author. More specifically, the difficulty was compounded by the novel's dramatization of the soul-crushing conflict between two such fantasies: one in the service of the masculine ideal of unflinching dedication to a heroic purpose, the other promising satisfaction to the equally potent demands of emotional and sexual desire. Features of Conrad's narrative fit so tightly and consistently with the theory as Freud (and Abraham) proposed and as Berman elaborated it that The Rescue offers itself as one of those rare and reinforcing instances wherein the literary text seems to validate the psychoanalytic theory at least as persuasively as the theory "understands" the text. PMID:24555549

  13. 6. View northeast of Ten Acre Lot with Joseph Fry ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. View northeast of Ten Acre Lot with Joseph Fry Farm complex (center) and Beehive House (right)in the background - Joseph Fry Farm Landscape, 2153 South County Trail Road (U.S. Route 2), East Greenwich, Kent County, RI

  14. 5. Photocopy of photograph (original negative owned by St. Joseph's ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Photocopy of photograph (original negative owned by St. Joseph's Church) Photographer unknown, pre 1905 INTERIOR BEFORE 1905 ALTERATIONS - St. Joseph's Roman Catholic Church, Main Street, Westphalia, Osage County, MO

  15. [Diseases and death of Joseph Pilsudski].

    PubMed

    Jeśman, Czesław; Młudzik, Agnieszka; Kula, Agnieszka

    2012-06-01

    Marshal Joseph Pilsudski did not belong to individuals who cared for their health. He avoided physicians and treatment. He appreciated only legion physicians such as Gen. Dr Stanisław Ruppert, Col. Dr Marcin Wroczyński and Col. DrAndrzej Mozołowki. Joseph Pilsudski was a heavy smoker and suffered from pulmonary emphysema for many years. In 1933 he caught a severe flu accompanied by some hepatic ailments and began losing his weight. In 1935, his liver became enlarged. He started vomiting and was very weak. All consultations were ineffective. He died from primary carcinoma of bile ducts on 12 May, 1935. PMID:22891570

  16. Obituary: Richard Joseph Elston, 1960-2004

    NASA Astrophysics Data System (ADS)

    Jannuzi, Buell Tomasson; Bechtold, Jill

    2004-12-01

    Richard Joseph Elston, known for his development of innovative astronomical instrumentation, died on 26 January 2004 in Gainesville, Florida, after a four-year battle with Hodgkin's lymphoma. A professor of astronomy at the University of Florida, Richard had an unusually broad range of interests and skills, and a willingness to share his passion for astronomy with others, which made him a highly valued member of the astronomical community. Born 1 July 1960, in Albuquerque, New Mexico, Richard was the son of a geologist father and journalist mother. His childhood interest in astronomy and instrumentation matured as he majored in physics and astronomy at the University of New Mexico (BS, 1983) under the mentorship of Michael Zeilik. Richard pursued his PhD in astronomy at the University of Arizona and earned his degree in 1988. He pioneered the use of IR arrays for deep imaging surveys of the sky to study galaxy formation, and completed his thesis Search for Rapidly Forming Galaxies at High Redshift under the direction of George Rieke. Richard's graduate work included the first detection of galaxies at intermediate redshifts with evolved populations too red to have been identifiable from optical imaging surveys alone. In the Astrophysical Journal Letters in 1988, he, George Rieke, and Marcia Rieke reported the discovery of this new class of galaxies, now known as EROs (Extremely Red Objects), important as the possible progenitors of present day elliptical galaxies. Following post-doctoral positions at Kitt Peak National Observatory from 1988 to 1991 and at the Observatories of the Carnegie Institution of Washington from 1991 to 1992, Richard joined the scientific staff of Cerro Tololo Inter-American Observatory in Chile, part of the NSF's National Optical Astronomy Observatory. By 1994, he had become head of CTIO's IR instrumentation program and was leading the development of new instruments for the US astronomical community. In 1996, Richard married astronomer

  17. DCEG Symposium to Honor Joseph F. Fraumeni, Jr. | Poster

    Cancer.gov

    By Nancy Parrish, Staff Writer On May 6, the Division of Cancer Epidemiology and Genetics (DCEG) will sponsor a symposium to honor 50 years of leadership from its founding director, Joseph F. Fraumeni, Jr., M.D., who stepped down from the position in July 2012. The conference, entitled “Cancer Epidemiology: From Pedigrees to Populations,” will highlight critical findings in cancer epidemiology from the last 50 years, as well as opportunities for future research directions. Long History of Leadership and Discovery

  18. Joseph Priestley: Docter Phlogiston or Reverend Oxygen?

    PubMed

    Fara, Patricia

    2010-09-01

    In propaganda material, people are often presented in black-and-white terms as either a villain or a hero. Although Joseph Priestley is denigrated for believing in the discredited substance phlogiston, he is also celebrated for discovering oxygen. PMID:20708802

  19. Selected Papers of Joseph T. Impellitteri.

    ERIC Educational Resources Information Center

    Baran, Anna DeSantis; Gilli, Angelo C., Sr.

    1975-01-01

    The collection of selected papers of Joseph T. Impellitteri reprints in full, or excerpts from, 46 unpublished position and conference papers, research and program proposals, and project reports, and from 20 published articles, chapters from edited collections, bulletins and special studies which Impellitteri authored or co-authored. The papers…

  20. Joseph Rotblat: Influences, Scientific Achievements and Legacy

    ERIC Educational Resources Information Center

    Underwood, Martin

    2008-01-01

    Joseph Rotblat was one of the most distinguished nuclear physicists and peace campaigners of the post Second World War period. His peace activities rank alongside those of Albert Einstein and Bertrand Russell; he won the Nobel Peace Prize, jointly with the Pugwash movement, that he helped found. However, he made significant contributions to…

  1. Content, Joseph Schwab and German "Didaktik"

    ERIC Educational Resources Information Center

    Deng, Zongyi

    2015-01-01

    This article attempts to extend and deepen the conversation concerning the knowledge-based approach to curriculum espoused by Michael Young in his 2013 "JCS" paper through revisiting the structure of the disciplines thinking of Joseph Schwab and German "Didaktik." It argues that curriculum making requires a theory of knowledge…

  2. Dynamics model of the IBR-2M pulsed reactor for analysis of fast transition processes

    NASA Astrophysics Data System (ADS)

    Pepelyshev, Yu. N.; Popov, A. K.; Sumkhuu, D.; Sangaa, D.

    2015-05-01

    A nonlinear model of the IBR-2M pulsed reactor dynamics relating values of variables at discreet instants of time (when power pulses appear) is developed on the basis of the MATLAB program system. The tests of the model by simulating calculated processes in the IBR-2M reactor proved the correctness of the model. A tentative estimate of the transfer coefficient for the linear part of the automatic regulator is obtained.

  3. Conceptual design of a new homogeneous reactor for medical radioisotope Mo-99/Tc-99m production

    SciTech Connect

    Liem, Peng Hong; Tran, Hoai Nam; Sembiring, Tagor Malem; Arbie, Bakri

    2014-09-30

    To partly solve the global and regional shortages of Mo-99 supply, a conceptual design of a nitrate-fuel-solution based homogeneous reactor dedicated for Mo-99/Tc-99m medical radioisotope production is proposed. The modified LEU Cintichem process for Mo-99 extraction which has been licensed and demonstrated commercially for decades by BATAN is taken into account as a key design consideration. The design characteristics and main parameters are identified and the advantageous aspects are shown by comparing with the BATAN's existing Mo-99 supply chain which uses a heterogeneous reactor (RSG GAS multipurpose reactor)

  4. Neutronic performance of the WWR-M research reactor in Ukraine.

    SciTech Connect

    Pond, R. B.; Hanan, N. A.; Matos, J. E.; Mahlers, Y.; Dyakov, A.; Technology Development; Kiev Inst. for Nuclear Research

    2002-01-01

    The 10 MW, WWR-M research reactor of the Kiev Institute for Nuclear Research is jointly studied with the Argonne National Laboratory to examine the feasibility of conversion from HEU (36%) to LEU (19.75%) fuel. A potential core configuration was chosen for comparison of analytical results with HEU fuel and candidate replacement LEU fuels. Core reactivity, fuel assembly power, experiment flux, fuel-cycle length, the number of fuel assemblies consumed per year, and shutdown margins are compared using HEU and LEU fuels. The reactor currently uses HEU (36%) WWR-M2 fuel assemblies (3 tubes, UO2-Al fuel meat with 1.1 gU/cm3 and 37.0 g {sup 235}U). Candidate LEU replacement fuel assemblies, which would result in the same fuel cycle length and the same annual fuel consumption as the HEU (36%) fuel are: LEU WWR-M2 (3 tubes, UO2-Al fuel meat with 2.3 gU/cm3 and 38.3 g 235U) and LEU WWR-MR (37 pins, U9Mo-Al fuel meat with 2.4 gU/cm3 and 38.1 g {sup 235}U). Five LEU WWR-M2 fuel assemblies with 41.7 g {sup 235}U per assembly, UO{sub 2}-Al fuel meat with 2.5 gU/cm3, and a fueled height of 50 cm have completed irradiation testing in the WWR-M reactor at the Petersburg Nuclear Physics Institute in Gatchina to an average 235U burnup of over 70%. This LEU fuel is considered to be qualified for conversion of the WWR-M reactor in Kiev and other research reactors using HEU (36%) WWR-M2 fuel assemblies. For reactors using assemblies with a fueled height of 60 cm, the 235U content per assembly would be 50 g with the same fuel meat composition as the fuel assemblies that were tested in Gatchina. Two 37-pin LEU test assemblies - one with UO{sub 2}-Al fuel meat and about 48 g {sup 235}U and the other with U9Mo-Al fuel meat and about 96 g {sup 235}U are scheduled to begin irradiation testing in the WWR-M reactor in Gatchina before the end of 2002. If these tests (lasting about two years) are successful, LEU pin-type fuel assemblies with up to 96 g 235U would be candidate fuels for LEU

  5. A human reliability analysis of the University of New Mexico's AGN- 201M nuclear research reactor

    SciTech Connect

    Brumburgh, G.P. ); Heger, A.S. . Dept. of Chemical and Nuclear Engineering)

    1992-10-15

    During 1990--1991, a probabilistic risk assessment was conducted on the University of New Mexico's AGN-201M nuclear research reactor to address the risk and consequence of a maximum hypothetical release accident. The assessment indicated a potential for consequential human error to precipitate Chis scenario. Subsequently, a human reliability analysis was performed to evaluate the significance of human interaction on the reactor's safety systems. This paper presents the results of that investigation.

  6. The Irradiation Facility at the IBR-2M Reactor in Dubna

    NASA Astrophysics Data System (ADS)

    Bulavin, M.; Cheplakov, A.; Kulikov, S.; Kukhtin, V.; Shabalin, E.; Verhoglyadov, A.

    2014-06-01

    After renovation neutron pulsed reactor was successfully put into operation. In view of HL-LHC development, the irradiation facility at the IBR-2m, previously used for the ATLAS Liquid Argon calorimeters electronics and materials certification, has been upgraded to permit accumulation in the warm temperature conditions of the fast neutrons fluences up to k*1017 n/cm2 per one standard reactor operation cycle - 11 days. The first test of materials for ATLAS was conducted.

  7. A molten Salt Am242M Production Reactor for Space Applications

    NASA Technical Reports Server (NTRS)

    Emrich, William

    2005-01-01

    The use of Am242m holds great promise for increasing the efficiency nuclear thermal rocket engines. Because Am242m has the highest fission cross section of any known isotope (1000's of barns), its extremely high reactivity may be used to directly heat a propellant gas with fission fragments. Since this isotope does not occur naturally, it must be bred in special production reactors designed for that purpose. The primary advantage to using molten salt reactors for breeding Am242m is that the reactors can be reprocessed continually yielding a constant rate of production of the isotope. Once built and initially fueled, the reactor will continually breed the additional fuel it needs to remain critical. The only feedstock required is a salt of U238. No enriched fuel is required during normal operation and all fissile material, except the Am242m, is maintained in a closed loop. For a reactor operating at 200 MW several kilograms of Am242m may be bred each year.

  8. Current status of advanced pelletized cold moderators development for IBR-2M research reactor

    NASA Astrophysics Data System (ADS)

    Kulikov, S.; Belyakov, A.; Bulavin, M.; Mukhin, K.; Shabalin, E.; Verhoglyadov, A.

    2013-03-01

    The world's first advanced pelletized cold neutron moderator is prepared to be put into operation at the IBR-2M pulsed research reactor. It provides long-wavelength neutrons to the most of neutron spectrometers at the beams of the IBR-2M reactor. Aromatic hydrocarbons are used as a material for cold moderators. It is a very attractive material because of its high radiation resistance, good moderating properties, incombustibility, etc. It is shown that the idea of beads transport by a helium flow at cryogenic temperatures is successful. The recent progress and plans for moderator development at the IBR-2M reactor as well as the experimental results of beads transport are discussed in the paper.

  9. Model and Mockup of DEMO Ceramic Breeding Zone for Testing in the IVV-2M Reactor

    SciTech Connect

    Kapychev, V.; Gorokhov, V.; Davydov, D.

    2001-01-15

    A model of a ceramic breeding zone has been designed and manufactured for testing in the IVV-2M fission reactor. The model contains both lithium orthosilicate and beryllium spheroid particles 1 to 2 mm in diameter. The structural material is ferritic-martensitic stainless steel. In addition, a mockup of the model for verification of neutronics calculation methods has been designed and manufactured. A special facility (Functional In-Reactor Investigations of Tritium-Breeding Models) has been designed, fabricated, and assembled at the reactor for studying the kinetics of tritium extraction from the ceramic material under irradiation. Neutronic and thermo-hydraulic calculations and an initial measurement of tritium release from the model under reactor irradiation have been performed.

  10. Astronaut Joseph Kerwin test subject Lower Body Negative Pressure experiment

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot, serves as test subject for the Lower Body Negative Pressure Experiment. Astronaut Paul J. Weitz, Skylab 2 pilot, assists Kerwin with the blood pressure cuff. They are in the experiment and work area of the Orbital Workshop crew quarters of the Skylab 1 and 2 space station cluster in Earth orbit. Kerwin is lying in the lower body negative pressure device. The purpose of the M092 experiment is to provide information concerning the time course of cardiovascular adaptation during flight, and to provide inflight data for predicting the degree of orthostatic intolerance and impairment of physical capacity to be expected upon return to Earth environment. The data collected in support of M092 are blood pressure, heart rate, body temperature, vectorcardiogram, LBNPD pressure, leg volume changes, and body weight.

  11. Mapping of the gene for Machado-Joseph disease within a 3.6-cM interval flanked by D14S291/D14S280 and D14S81, on the basis of studies of linkage and linkage disequilibrium in 24 Japanese families

    SciTech Connect

    Sasaki, Hidenao; Ihara, Tatsuo; Wakisaka, Akemi; Takada, Akio; Yoshiki, Takashi; Hamada, Takeshi; Suzuki, Yoshihiro; Iwabuchi, Kiyoshi; Onari, Keiko; Tada, Jyoji

    1995-01-01

    The gene locus of Machado-Joseph disease (MJD) has recently been mapped within a 29-cM subregion of 14q chromosome. We did a linkage study of 24 multigenerational MJD Japanese pedigrees, in an attempt to narrow the candidate region of this gene. Pairwise and multipoint linkage analysis, together with haplotype segregation analysis, led to the conclusion that the MJD gene is located at the 6.8-cM interval between D14S256 and D14S81 (Z{sub max} = 24.78, multipoint linkage analysis). D14S291 and D14S280, located at the center of this interval, showed no obligate recombination with the MJD gene (Z{sub max} = 5.93 for D14S291 and 9.99 for D14S280). A weak, but significant, linkage disequilibrium of MJD gene was noted with D14S81 (P<.05) but not with D14S291 or D14S280. These results suggest that a 3.6-cM interval flanked by D14S291/D14S280 and D14S81 is the most likely location of the MJD gene and that it is closest to D14S81. 33 refs., 4 figs., 6 tabs.

  12. Interview--Cliff Joseph: Art Therapist, Pioneer, Artist.

    ERIC Educational Resources Information Center

    Riley-Hiscox, Anna

    1997-01-01

    Interview of Cliff Joseph, one of the first African Americans to participate in the American Art Therapy Association and to become a registered art therapist and teacher. Details Joseph's impact on art therapy and cultural and social issues, as well as his relationships with other prominent art therapists. (MKA)

  13. Tribes of Men: John Joseph Mathews and Indian Internationalism

    ERIC Educational Resources Information Center

    Lutenski, Emily

    2012-01-01

    In this article, the author discusses John Joseph Mathews and Indian internationalism. As an old man, Osage intellectual, writer, and historian, John Joseph Mathews recalled his expatriation from the United States during the 1920s. After growing up in Pawhuska, Oklahoma, seat of the Osage Nation, where he had been born in 1894 to a white mother…

  14. 33 CFR 110.193a - St. Joseph Bay, Fla.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false St. Joseph Bay, Fla. 110.193a... ANCHORAGE REGULATIONS Anchorage Grounds § 110.193a St. Joseph Bay, Fla. (a) The anchorage grounds—(1... northeast of the north entrance channel to Port St. Joe, Florida. (2) Explosives Anchorage Area 2....

  15. 33 CFR 110.193a - St. Joseph Bay, Fla.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false St. Joseph Bay, Fla. 110.193a... ANCHORAGE REGULATIONS Anchorage Grounds § 110.193a St. Joseph Bay, Fla. (a) The anchorage grounds—(1... northeast of the north entrance channel to Port St. Joe, Florida. (2) Explosives Anchorage Area 2....

  16. 33 CFR 110.193a - St. Joseph Bay, Fla.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false St. Joseph Bay, Fla. 110.193a... ANCHORAGE REGULATIONS Anchorage Grounds § 110.193a St. Joseph Bay, Fla. (a) The anchorage grounds—(1... northeast of the north entrance channel to Port St. Joe, Florida. (2) Explosives Anchorage Area 2....

  17. SCC and corrosion evaluations of the F/M steels for a supercritical water reactor

    NASA Astrophysics Data System (ADS)

    Hwang, Seong Sik; Lee, Byung Hak; Kim, Jung Gu; Jang, Jinsung

    2008-01-01

    As one of the Generation IV nuclear reactors, a supercritical water cooled reactor (SCWR) is being considered as a candidate reactor due to its high thermal efficiency and simple reactor design without steam generators and steam separators. For the application of a structural material to a core's internals and a fuel cladding, the material should be evaluated in terms of its corrosion and stress corrosion cracking susceptibility. Stress corrosion cracking and general corrosion tests of ferritic-martensitic (F/M) steels, high Ni alloys and an oxide dispersion strengthened (ODS) alloy were performed. Stress corrosion cracking (SCC) was not observed on the fractured surface of the T 91 steel in the supercritical water at 500, 550 and 600 °C. As the test temperature increased, the ultimate tensile strength (UTS) and yield strength (YS) of T 91 decreased, and a high dissolved oxygen level induced corrosion and low ductility. The F/M steels showed a high corrosion rate whereas the Ni base alloys showed a little corrosion at 500 and 550 °C. Corrosion rate of the F/M steels at 600 °C test was up to three times larger than that at 500 °C. A thin layer composed of Mo and Ni seems to retard the Cr diffusion into the out layer of the corrosion product of T 92 and T 122.

  18. Obituary: Richard Joseph Elston, 1960-2004

    NASA Astrophysics Data System (ADS)

    Jannuzi, Buell Tomasson; Bechtold, Jill

    2004-12-01

    Richard Joseph Elston, known for his development of innovative astronomical instrumentation, died on 26 January 2004 in Gainesville, Florida, after a four-year battle with Hodgkin's lymphoma. A professor of astronomy at the University of Florida, Richard had an unusually broad range of interests and skills, and a willingness to share his passion for astronomy with others, which made him a highly valued member of the astronomical community. Born 1 July 1960, in Albuquerque, New Mexico, Richard was the son of a geologist father and journalist mother. His childhood interest in astronomy and instrumentation matured as he majored in physics and astronomy at the University of New Mexico (BS, 1983) under the mentorship of Michael Zeilik. Richard pursued his PhD in astronomy at the University of Arizona and earned his degree in 1988. He pioneered the use of IR arrays for deep imaging surveys of the sky to study galaxy formation, and completed his thesis Search for Rapidly Forming Galaxies at High Redshift under the direction of George Rieke. Richard's graduate work included the first detection of galaxies at intermediate redshifts with evolved populations too red to have been identifiable from optical imaging surveys alone. In the Astrophysical Journal Letters in 1988, he, George Rieke, and Marcia Rieke reported the discovery of this new class of galaxies, now known as EROs (Extremely Red Objects), important as the possible progenitors of present day elliptical galaxies. Following post-doctoral positions at Kitt Peak National Observatory from 1988 to 1991 and at the Observatories of the Carnegie Institution of Washington from 1991 to 1992, Richard joined the scientific staff of Cerro Tololo Inter-American Observatory in Chile, part of the NSF's National Optical Astronomy Observatory. By 1994, he had become head of CTIO's IR instrumentation program and was leading the development of new instruments for the US astronomical community. In 1996, Richard married astronomer

  19. Joseph F. Poland (1908-1991)

    NASA Astrophysics Data System (ADS)

    Johnson, A. Ivan

    On June 4, 1991, AGU Fellow Joseph Fairfield Poland died in a Sacramento, Calif., hospital at the age of 83 after a long fight with Parkinson's Disease. A recognized expert on land subsidence and a retiree from the U.S. Geological Survey's Water Resources Division, his death occurred only 2 weeks after the end of the 4th International Symposium on Land Subsidence, held in Houston, Tex. Frequently known as “Mr. Land Subsidence,” it was appropriate that the proceedings of that symposium had been dedicated to him.Born in Boston, Poland earned a bachelor's degree in geology from Harvard University in 1929. He was resident geologist for Tropical Oil Company in Colombia from 1929 to 1931. After returning to the United States, Poland earned his master's degree in geology from Stanford University in 1935, taught groundwater hydrology, and consulted on groundwater and geophysical problems in the West and Southwest.

  20. Joseph Leidy: his contributions to otology.

    PubMed

    Meyers, A

    1976-09-01

    Few men of science have contributed more to our understanding of the workings of nature than Joseph Leidy. Philosopher, anatomist, paleontologist, botanist, educator, and natural scientist in the purest sense of the work, Leidy's interest in the humanities and in all aspects of nature lent itself to his exact descriptions of new species and unchartered anatomic realms. His insistence on man's acquaintance with nature fostered a humanistic and sensitive approach to life, something that needs more emphasis today. This communication deals with Leidy's life, his philosophy, and his unique dedication to the study of nature. An appreciation and understanding of his anatomic expertise, particularly of the temporal bone, hopefully will sensitize the modern otologist to the heart and mind of one that preceded him. PMID:786235

  1. Investigation of the low enrichment conversion of the Texas A and M Nuclear Science Center Reactor

    SciTech Connect

    Reuscher, J.A.

    1988-01-01

    The use of highly enriched uranium as a fuel research reactors is of concern due to the possibility of diversion for nuclear weapons applications. The Texas A M TRIGA reactor currently uses 70% enriched uranium in a FLIP (Fuel Life Improvement Program) fuel element manufactured by General Atomics. Thus fuel also contains 1.5 weight percent of erbium as a burnable poison to prolong useful core life. US university reactors that use highly enriched uranium will be required to covert to 20% or less enrichment to satisfy Nuclear Regulatory Commission requirements for the next core loading if the fuel is available. This investigation examined the feasibility of a material alternate to uranium-zirconium hydride for LEU conversion of a TRIGA reactor. This material is a beryllium oxide uranium dioxide based fuel. The theoretical aspects of core physics analyses were examined to assess the potential advantages of the alternative fuel. A basic model was developed for the existing core configuration since it is desired to use the present fuel element grid for the replacement core. The computing approach was calibrated to the present core and then applied to a core of BeO-UO{sub 2} fuel elements. Further calculations were performed for the General Atomics TRIGA low-enriched uranium zirconium hydride fuel.

  2. A human reliability analysis of the University of New Mexico`s AGN- 201M nuclear research reactor. Revision 1

    SciTech Connect

    Brumburgh, G.P.; Heger, A.S.

    1992-10-15

    During 1990--1991, a probabilistic risk assessment was conducted on the University of New Mexico`s AGN-201M nuclear research reactor to address the risk and consequence of a maximum hypothetical release accident. The assessment indicated a potential for consequential human error to precipitate Chis scenario. Subsequently, a human reliability analysis was performed to evaluate the significance of human interaction on the reactor`s safety systems. This paper presents the results of that investigation.

  3. Measurement of cold neutron spectra using a model cryogenic moderator of the IBR-2M reactor

    NASA Astrophysics Data System (ADS)

    Kulikov, S. A.; Kalinin, I. V.; Morozov, V. M.; Novikov, A. G.; Puchkov, A. V.; Chernikov, A. N.; Shabalin, E. P.

    2010-01-01

    The method and results of an experiment to determine the cold neutron spectrum from solid mesitylene at moderator temperatures of 10-50 K are presented. This study was performed at the DIN-2PI spectrometer of the IBR-2 reactor. The objective of the study was to verify the system of constants used in the Monte Carlo simulation of cryogenic neutron moderators of the IBR-2M reactor and to obtain the cold neutron yield as a function of the moderator temperature. Satisfactory agreement between the experimental and calculated neutron spectra at a mesitylene temperature of 20 K has been obtained; the ratio of cold neutron intensities at 10 and 50 K is ˜1.8.

  4. 18. Historic American Buildings Survey Joseph Hill, Photographer May 26, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Historic American Buildings Survey Joseph Hill, Photographer May 26, 1936 FIREPLACE IN DINING ROOM, The Davenport House, Rock Island Arsenal - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  5. 1. Historic American Buildings Survey Joseph Hill, Photographer July 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer July 1936 STAIR RAILING, 66 WEST OAK STREET - Chicago Ironwork, 66 West Oak Street (Cast Iron Stair Railing), 66 West Oak Street, Chicago, Cook County, IL

  6. 2. PERSPECTIVE LOOKING NORTH BY 300 DEGREES CHIEF JOSEPH DAM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. PERSPECTIVE LOOKING NORTH BY 300 DEGREES CHIEF JOSEPH DAM INTERPRETIVE CENTER IN FOREGROUND - Columbia River Bridge at Bridgeport, State Route 17 spanning Columbia River, Bridgeport, Douglas County, WA

  7. 7. CHIEF JOSEPH DAM AND POWERHOUSE TO LEFT OF PICTURE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. CHIEF JOSEPH DAM AND POWERHOUSE TO LEFT OF PICTURE COLUMBIA RIVER BRIDGE AT BRIDGEPORT TO RIGHT OF DOWNSTREAM - Columbia River Bridge at Bridgeport, State Route 17 spanning Columbia River, Bridgeport, Douglas County, WA

  8. 1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 #12 EARLY RED BRICK HOUSE, Elk and Prospect Sts., Galena, Illinois - Galena Doorways, Red Brick House, Elk & Prospect Streets, Galena, Jo Daviess County, IL

  9. 6. Detail of pilaster cap. Aug. 10, 1936. Joseph Hill, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Detail of pilaster cap. Aug. 10, 1936. Joseph Hill, photographer, copied from small photo taken by survey member. - Jansonist Colony, Steeple Building, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  10. 3. West and south elevations. Joseph Hill, photographer, copied from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. West and south elevations. Joseph Hill, photographer, copied from photo lent by Evelyn S. Craig. August 1936. - Jansonist Colony, Steeple Building, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  11. 1. Historic American Buildings Survey Joseph Hill, Photographer August 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer August 1936 FIRST ORIGINAL STORE AND POSTOFFICE, COPY OF AN EARLY PHOTOGRAPH. LENT BY EVELYN S. CRAIG - Jansonist Colony, Colony Store & Post Office, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  12. 7. Detail of balcony rail. August 1936. Joseph Hill, photographer, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Detail of balcony rail. August 1936. Joseph Hill, photographer, copied from small photo taken by survey member. - Jansonist Colony, Steeple Building, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  13. 2. Historic American Buildings Survey Joseph Hill, Photographer July 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Joseph Hill, Photographer July 1936 BALCONY RAILING, 945 NO. DEARBORN ST. JUDGE CARPENTER'S HOME - Chicago Ironwork, Judge Carpenter House (Cast Iron Balcony Railing), 945 North Dearborn Street, Chicago, Cook County, IL

  14. 3. Historic American Buildings Survey Joseph Hill, Photographer June, 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey Joseph Hill, Photographer June, 1936 DETAIL OF BALCONY RAILING, 945 NO. DEARBORN ST. JUDGE CARPENTER'S HOME - Chicago Ironwork, Judge Carpenter House (Cast Iron Balcony Railing), 945 North Dearborn Street, Chicago, Cook County, IL

  15. 12. Historic American Buildings Survey Joseph Hill, Photographer July 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Historic American Buildings Survey Joseph Hill, Photographer July 10, 1936 SOUTH ELEVATION (Copied from student's drawing, Dept. of Architecture, Armour Institute of Technology. Chicago) - Keating House, U.S. Highway 430, Fayville, Alexander County, IL

  16. 1. Historic American Buildings Survey Joseph Hill, Photographer Oct. 25, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer Oct. 25, 1936 #1 MAXIENER HOUSE 104 South Bench Street Galena, Illinois - Galena Doorways, Elizabeth Maxiener Cottage, 104 South Bench Street, Galena, Jo Daviess County, IL

  17. 1. Historic American Buildings Survey Joseph Hill, Photographer 1936 #4 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer 1936 #4 FORMERLY SISTERS OF MERCY CONVENT 226 North Bench Street, Galena, Illinois. - Galena Doorways, Sisters of Mercy Convent, 226 North Bench Street, Galena, Jo Daviess County, IL

  18. 1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 #2 PORTER HOUSE, 110 Bench St. Galena, Illinois - Galena Doorways, Porter House, 110 North Bench Street, Galena, Jo Daviess County, IL

  19. 1. Historic American Buildings Survey Copied by Joseph Hill from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Copied by Joseph Hill from an old photograph loaned by Alice Snyder, Galena, Illinois. SOUTH EAST ELEVATION - Grace Episcopal Church, South Prospect Street, Galena, Jo Daviess County, IL

  20. 1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 #5 GRIMM HOUSE 608 South Bench Street, Galena. - Galena Doorways, Heike Grimm House, 608 South Bench Street, Galena, Jo Daviess County, IL

  1. 1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 #7 KLINGEL HOUSE ON BENCH STREET Galena, Illinois - Galena Doorways, Peter Klingel House, Bench Street, Galena, Jo Daviess County, IL

  2. 1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 #3 HEMPSTEAD HOUSE (about 1846) 611 South Bench Street, Galena, Ill. - Galena Doorways, Charles Hempstead House, 611 South Bench Street, Galena, Jo Daviess County, IL

  3. 1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 #13 EARLY WAREHOUSE South Main Street, South of Booth, Galena, Illinois - Galena Doorways, Warehouse, South Main Street, Galena, Jo Daviess County, IL

  4. 1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 #6 CALDERWOOD HOUSE (1839) North Bench Street, Galena, Ill. - Celia Calderwood House, North Bench Street, Galena, Jo Daviess County, IL

  5. 1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 #8 STAIR RAILING TELFORD SHOP Bench Street, Galena, Ill. - Galena Doorways, Telford Shop, Bench Street, Galena, Jo Daviess County, IL

  6. 1. Historic American Buildings Survey Joseph Hill, Photographer October 25, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer October 25, 1936 #9 HARMONY LODGE ON BENCH STREET (1858) - Galena Doorways, Harmony Lodge of Odd Fellows, Bench Street, Galena, Jo Daviess County, IL

  7. 1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 #10 Early Methodist Church, Later Odd Fellows Lodge on Bench Street. - Galena Doorways, First Methodist Church, Bench Street, Galena, Jo Daviess County, IL

  8. 1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 #16 OLD DOWLING HOUSE (Broadway), Galena - Galena Doorways, John Dowling House, Main & Diagonal Streets, Galena, Jo Daviess County, IL

  9. 3. Historic American Buildings Survey Joseph Hill, Photographer August 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey Joseph Hill, Photographer August 1936 BRONZE TABLET HISTORICAL MARKER - Hobson Grist Mill (Monument & Millstones), DuPage County Pioneer Park, Naperville, Du Page County, IL

  10. REACTOR

    DOEpatents

    Szilard, L.

    1963-09-10

    A breeder reactor is described, including a mass of fissionable material that is less than critical with respect to unmoderated neutrons and greater than critical with respect to neutrons of average energies substantially greater than thermal, a coolant selected from sodium or sodium--potassium alloys, a control liquid selected from lead or lead--bismuth alloys, and means for varying the quantity of control liquid in the reactor. (AEC)

  11. REACTOR

    DOEpatents

    Christy, R.F.

    1961-07-25

    A means is described for co-relating the essential physical requirements of a fission chain reaction in order that practical, compact, and easily controllable reactors can be built. These objects are obtained by employing a composition of fissionsble isotope and moderator in fluid form in which the amount of fissionsble isotcpe present governs the reaction. The size of the reactor is no longer a critical factor, the new criterion being the concentration of the fissionable isotope.

  12. Cholangicarcinoma Presenting as a Sister Mary Joseph Nodule

    PubMed Central

    Rangegowda, Devaraja; Vyas, Tanmay; Grover, Shrruti; Joshi, YK; Sharma, Chhagan; Sahney, Amrish

    2016-01-01

    Sister Mary Joseph nodules represent metastatic cancer of the umbilicus. More than half of these cases are attributable to gastrointestinal malignancies including gastric, colonic, and pancreatic cancer. In addition, gynecologic (ovarian, uterine cancer), unknown primary tumors, and, rarely, bladder or respiratory malignancies may cause umbilical metastasis. We report the case of a Sister Mary Joseph nodule originating from a hilar cholangiocarcinoma. Umbilical nodules should prompt clinical evaluation, as these tumors are usually associated with poor prognosis. PMID:27144207

  13. Joseph Priestley, oxygen, and the enlightenment.

    PubMed

    West, John B

    2014-01-01

    Joseph Priestley (1733–1804) was the first person to report the discovery of oxygen and describe some of its extraordinary properties. As such he merits a special place in the history of respiratory physiology. In addition his descriptions in elegant 18th-century English were particularly arresting, and rereading them never fails to give a special pleasure. The gas was actually first prepared by Scheele (1742–1786) but his report was delayed. Lavoisier (1743–1794) repeated Priestley's initial experiment and went on to describe the true nature of oxygen that had eluded Priestley, who never abandoned the erroneous phlogiston theory. In addition to oxygen, Priestley isolated and characterized seven other gases. However, most of his writings were in theology because he was a conscientious clergyman all his life. Priestley was a product of the Enlightenment and argued that all beliefs should be able to stand the scientific scrutiny of experimental investigations. As a result his extreme liberal views were severely criticized by the established Church of England. In addition he was a supporter of both the French and American Revolutions. Ultimately his political and religious attitudes provoked a riot during which his home and his scientific equipment were destroyed. He therefore emigrated to America in 1794 where his friends included Thomas Jefferson and Benjamin Franklin. He settled in Northumberland, Pennsylvania although his scientific work never recovered from his forced departure. But the descriptions of his experiments with oxygen will always remain a high point in the history of respiratory physiology. PMID:24285268

  14. [Bioethical arguments in Joseph Ratzinger's thinking].

    PubMed

    Martínez-Carbonell López, Alfonso

    2014-01-01

    In the dense theological thought of Joseph Ratzinger before his election as pope, we find fundamental contributions to contemporary bioethics. Starting from the assumption of the close relationship between faith and science he incorporates a necessary theological dimension in the bioethical dialogue that illuminates and clarifies the answers to the real questions raised in bioethical actions. On the one hand, there is the question of the origin of man that is understood as God's creation as opposed to a purely biological origin to which a modern pseudoscientific stance wants to confine it. On the other hand, there is the question about man's identity, which is understood as the image of God, from which stems the inviolable dignity and sacredness of human life, overcoming scientistic materialism. Finally, we find the question of how to treat the ″other″, even the embryo, as a result of its lofty dignity, analyzing the ethical and legal consequences that exude from their nature and are summarized in the duty to protect and respect the other which the law should protect against the abuse of those who are stronger. PMID:25329412

  15. Joseph Henry's Conception of Scientific Knowledge

    NASA Astrophysics Data System (ADS)

    Theerman, Paul

    1997-04-01

    Joseph Henry, America's premier physicist and physics teacher in the mid-nineteenth century, had decided views of scientific knowledge. These were expressed in two ways. First of all, scientific knowledge led to moral betterment. Thus the study of science was a morally good thing. This was not only because it led to the contemplation of God's creation, which was a standard reason justifying the study of science dating from the Scientific Revolution and even earlier. More importantly, the study of science itself was a moral discipline, imparting to scientists the habits and virtues of truthfulness, respect for others, care and diligence, and the discernment of meaningful patterns from experience. The moral ideals of science were expressed most strongly in Henry's upholding the international "Republic of Science"; conversely, cheapening science was a sign of moral failure. Second, for Henry and his generation, science provided a path to sure truth, separate from falsehood of both the politics and the quackery that characterized mid-century public life. Henry promoted this in his championing of the Smithsonian Institution a scientific establishment, against the ideas of others who wanted to make it a literary establishment or a training school for teachers. For Henry, the Smithsonian's scientific reputation would be established by relying on careful peer review in its publications, and supporting established scientists to write authoritative popular works. The purpose of both these activities was to raise the profile of science in the United States and further establish science and the scientific method as a guide to public life.

  16. Straight talk with...Joseph Schwartz.

    PubMed

    Ratner, Mark

    2012-06-01

    On 17 May, Human Genome Sciences (HGS) formally rejected a $2.6 billion unsolicited takeover offer by GlaxoSmithKline. The Maryland-based biotech firm had long partnered with the UK drug giant to develop drugs including Benlysta (belimumab), HGS's first drug on the market and the first new medicine approved to fight lupus in 50 years. But, at $13 a share, GSK's bid was deemed "inadequate" by the HGS board. Recent history in the biotech sector shows how high the stakes are in such negotiations. Since last November, six biopharma buyouts have exceeded $1 billion each, with Gilead Sciences' purchase last year of the hepatitis C specialist Pharmasset topping the charts at a whopping $11.2 billion, the highest ever paid for a clinical-stage biotech and an 89% premium to its share price at the time. More recently, in April AstraZeneca paid $1.3 billion for Ardea Biosciences, a company with cancer and gout drugs in the pipeline but nothing on the market.One person watching the upward clime of such deals is biopharma analyst Joseph Schwartz, a managing director at Leerink Swann in Boston. Mark Ratner sought out Schwartz, who was named the top stock picker for pharmaceuticals in the last year's FT/StarMine Analyst Awards, for his views on what's behind the recent buyout spending. PMID:22673987

  17. Joseph Rotblat: influences, scientific achievements and legacy

    NASA Astrophysics Data System (ADS)

    Underwood, Martin

    2008-11-01

    Joseph Rotblat was one of the most distinguished nuclear physicists and peace campaigners of the post Second World War period. His peace activities rank alongside those of Albert Einstein and Bertrand Russell; he won the Nobel Peace Prize, jointly with the Pugwash movement, that he helped found. However, he made significant contributions to science, and in particular to the medical applications of accelerators, radiation and radio-nuclides. In this article his early work and influences in Poland are described. He then joined James Chadwick at Liverpool University and began work on the cyclotron recently constructed there. Rotblat then, together with Chadwick, joined the Manhattan Project. This experience was to shape his life. He stayed at Los Alamos for less than a year before walking out. He was suspected of being a spy. Rotblat then became Professor of Physics at St Bartholomew's Medical College and pioneered the use of a 15 MeV linear accelerator in treatment and research. He made fundamental contributions to understanding the effects of the fallout from nuclear bomb tests. He also, together with Patricia Lindop, made important contributions to understanding the biological effects of radiation.

  18. REACTOR

    DOEpatents

    Roman, W.G.

    1961-06-27

    A pressurized water reactor in which automatic control is achieved by varying the average density of the liquid moderator-cooiant is patented. Density is controlled by the temperature and power level of the reactor ftself. This control can be effected by the use of either plate, pellet, or tubular fuel elements. The fuel elements are disposed between upper and lower coolant plenum chambers and are designed to permit unrestricted coolant flow. The control chamber has an inlet opening communicating with the lower coolant plenum chamber and a restricted vapor vent communicating with the upper coolant plenum chamber. Thus, a variation in temperature of the fuel elements will cause a variation in the average moderator density in the chamber which directly affects the power level of the reactor.

  19. REACTORS

    DOEpatents

    Spitzer, L. Jr.

    1961-10-01

    Thermonuclear reactors, methods, and apparatus are described for controlling and confining high temperature plasma. Main axial confining coils in combination with helical windings provide a rotational transform that avoids the necessity of a figure-eight shaped reactor tube. The helical windings provide a multipolar helical magnetic field transverse to the axis of the main axial confining coils so as to improve the effectiveness of the confining field by counteracting the tendency of the more central lines of force in the stellarator tube to exchange positions with the magnetic lines of force nearer the walls of the tube. (AEC)

  20. Treatment of strong domestic sewage in a 96 m3 UASB reactor operated at ambient temperatures: two-stage versus single-stage reactor.

    PubMed

    Halalsheh, M; Sawajneh, Z; Zu'bi, M; Zeeman, G; Lier, J; Fayyad, M; Lettinga, G

    2005-03-01

    A 96 m3 UASB reactor was operated for 2.5 years under different conditions to assess the feasibility of treating strong sewage (COD(tot) = 1531 mg/l) at ambient temperatures with averages of 18 and 25 degrees C for winter and summer respectively. During the first year, the reactor was operated as a two-stage system at OLRs in the range of 3.6-5.0 kg COD/m3 d for the first stage and 2.9-4.6 kg COD/m3 d for the second stage. The results of the first stage showed average removals of 51% and 60% for COD(tot) and COD(ss) respectively without significant effect of temperature. The second stage reactor was unstable. The temperature affected sludge stabilization. During the second year, the first stage was operated as a single-stage UASB reactor at half of the previous loading rates. The results showed an average removal efficiency of 62% for COD(tot) during summer, while it dropped to 51% during wintertime. However, the effluent suspended solids were stabilized with VSS/TSS ratio around 0.50 all over the year. The sludge in the single-stage reactor was well-stabilized and exerted an excellent settlability. During the last three months of research, sludge was discharged regularly from the single-stage UASB reactor. The results showed no significant improvement in the performance in terms of COD(tot). Based on the results of the experiment, a single-stage UASB reactor operated at relatively long HRT is preferred above two-stage system at the Jordanian conditions. PMID:15501665

  1. Saint Joseph's University Institute for Environmental Stewardship

    SciTech Connect

    McCann, Michael P; Springer, Clint

    2013-10-15

    Task A: Examination of the physiological, morphological, and reproductive responses of Panicum virgatum (switchgrass) cultivars identified as potential biofuel producing cultivars as well as naturally-occurring varieties of switchgrass to projected changes in climate for the central portion of the United States. This project was a multi-year project set in a field site located at the Konza Prairie Biological Station near Manhattan, KS USA. At the field site we planted switchgrass collected from regions in Kansas, Oklahoma, and Texas. After a year of establishment we implemented a set of two-year water treatments that examined the responses in physiology, growth and development of switchgrass to predicted changes in precipitation amount for the central United States. After this experiment was completed we performed a second set of experiments that examined the responses of switchgrass physiology, growth, and development to changes in precipitation frequency. We also included in this analysis how genome size of individuals influenced their responses to precipitation frequency changes. Generally, we found switchgrass to be unresponsive to realistic predictions of precipitation changes for the Central Plains of the United States. These studies have provided significant insight into how this important grassland species will respond to future climate change from both an ecological and applied biological perspective. Finally, we provided insight into the mechanism through which this species changes in the face of altered water availability by not supporting the hypothesis that the control of switchgrass responses to changes in precipitation is altered by genome size. Task B: Installation of an extensive green roof system on the Science Center at Saint Joseph's University for research, research-training and educational outreach activities. An experimental green roof system was designed and installed by an outside contractor (Roofmeadows) on the roof of the Science Center

  2. Studies of plasma chemistry in a modified Gaseous Electronics Conference (mGEC) research reactor

    NASA Astrophysics Data System (ADS)

    Zhou, Bao; Joseph, E. A.; Liu, Yonghua; Overzet, L. J.; Goeckner, M. J.

    2002-10-01

    The mGEC research reactor has been designed to study plasma chemistry-surface interactions. Often, to obtain general chemistry parameters a Fourier transform infrared (FTIR) spectrometer using a single pass IR beam is employed. Such arrangements suffer from low signal to noise ratio for low density chemical species. The signal to noise ratio can be improved by increasing the path length of the IR beam through the discharge. This can be done by adding a multi-pass system, such as a White cell. We have added such a system to the mGEC. We use it to examine radial species concentrations in CF4 discharges, with various internal chamber configurations. This work is supported by a grant from NSF / DOE, CTS-0078669.

  3. REACTOR

    DOEpatents

    Spitzer, L. Jr.

    1962-01-01

    The system conteraplates ohmically heating a gas to high temperatures such as are useful in thermonuclear reactors of the stellarator class. To this end the gas is ionized and an electric current is applied to the ionized gas ohmically to heat the gas while the ionized gas is confined to a central portion of a reaction chamber. Additionally, means are provided for pumping impurities from the gas and for further heating the gas. (AEC)

  4. Some Considerations on {sup 242m}Am Production in Thermal Reactors

    SciTech Connect

    Cesana, Alessandra; Mongelli, Sara Tania; Terrani, Mario; Benetti, Pietro; Calligarich, Elio; Dolfini, Rinaldo; Raselli, Gian Luca

    2004-10-15

    Recently, it has been suggested to consider {sup 242m}Am as a potential nuclear fuel. This artificial nuclide can be produced through {sup 241}Am neutron capture carried on in a neutron field typical of a thermal reactor. In order to suppress the thermal neutron flux, which will cause {sup 242m}Am depletion mainly through fission, proper neutron filters should be adopted. In a very intense neutron field, the {sup 242m}Am enrichment depends mainly on the energy distribution of the neutrons, the sample thickness, and the cutoff energy of the neutron filter.An investigation on different geometries of the sample to be irradiated using Cd, B, Sm, and Gd as neutron filters has been carried out by means of Monte Carlo simulation. The most favorable results have been obtained irradiating thin {sup 241}Am samples (11 {mu}g/cm{sup 2}) covered with a Gd (0.2-mm-thick) or Sm (1-mm-thick) filter. In these cases the theoretical {sup 242m}Am enrichment can reach 20%.The preparation of significant quantities of this unconventional nuclear fuel implies isotopic separation techniques operating in high radioactive environments and hopefully characterized by very high recovery factors, which are in no way trivial problems.

  5. 75 FR 27372 - University of New Mexico; University of New Mexico AGN-201M Reactor; Environmental Assessment and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ... COMMISSION University of New Mexico; University of New Mexico AGN-201M Reactor; Environmental Assessment and... considering issuance of a renewed Facility Operating License No. R-102, to the University of New Mexico (the licensee), which would authorize continued operation of the University of New Mexico AGN-201M...

  6. A concept for the modernization of a SANS instrument at the IBR-2M pulsed reactor

    NASA Astrophysics Data System (ADS)

    Erhan, R. V.; Manoshin, S.; Pepy, G.; Kuklin, A. I.; Belushkin, A. V.; Zamfir, N. V.

    2011-04-01

    We consider a new configuration for a neutron small angle scattering instrument at the pulsed IBR-2M reactor with a mixed (cold and thermal) moderator system. This system provides added-up spectra from the cold and thermal parts of the moderator. We have installed the spectrometer using a special collimation system formed by two parts: primary with neutron optics element (divergent neutron guide) and secondary (installed after the divergent neutron guide) with a multiple pinhole collimation system. Our efforts have the goal to obtain smaller Qmin values (as well as higher resolution) with the possibilities to take advantage of an increased neutron flux compared with the present SANS spectrometer in the limited beam hall size. The Monte Carlo simulations will be used to choose and optimize the spectrometer and extraction system using VITESS software package.

  7. Saint Joseph's University Institute for Environmental Stewardship

    SciTech Connect

    McCann, Michael; Springer, Clint

    2014-06-18

    future climate scenarios is local adaptation and not necessarily genome size as has been hypothesized in the literature. Task B: Installation of an extensive green roof system on the Science Center at Saint Joseph's University for research, research-training and educational outreach activities. An experimental green roof system was designed and installed by an outside contractor (Roofmeadows) on the roof of the Science Center at Saint Joseph's University. The roof system includes four test plots, each with a different drainage system, instrumentation to monitor storm water retention, roof deck temperature, heat flux into and out of the building, rain fall, wind speed and direction, relative humidity and heat emission from the roof system. The vegetative roof was planted with 26 species of plants, distributed throughout the roof area, to assess species/variety growth and coverage characteristics, both in terms of the different drain layer systems, and in terms of the different exposures along the north to south axis of the building. Analysis of the drain layer performance, in terms of storm water retention, shows that the aggregate (stone) drainage layer system performed the best, with the moisture management mat system second, and the geotextile drain layer and reservoir sheet layer systems coming in last. This information is of value in the planning and design of vegetative roof systems since the different types of drainage layer systems have different installation costs and different weights. The different drainage layer systems also seem to be having an impact on plant growth and spread with the test plot with the reservoir sheet layer actually having the poorest plant coverage and plant spread of all areas of the roof studied. Plant growth performance analysis is ongoing, but significant differences have been observed in the third growing season ('13) along the north to south axis, with most species doing better towards the northern end of the roof (in terms of

  8. Saint Joseph's University Institute for Environmental Stewardship

    SciTech Connect

    McCann, Michael P.; Springer, Clint J.

    2014-06-05

    future climate scenarios is local adaptation and not necessarily genome size as has been hypothesized in the literature. Task B: Installation of an extensive green roof system on the Science Center at Saint Joseph's University for research, research-training and educational outreach activities. An experimental green roof system was designed and installed by an outside contractor (Roofmeadows) on the roof of the Science Center at Saint Joseph's University. The roof system includes four test plots, each with a different drainage system, instrumentation to monitor storm water retention, roof deck temperature, heat flux into and out of the building, rain fall, wind speed and direction, relative humidity and heat emission from the roof system. The vegetative roof was planted with 26 species of plants, distributed throughout the roof area, to assess species/variety growth and coverage characteristics, both in terms of the different drain layer systems, and in terms of the different exposures along the north to south axis of the building. Analysis of the drain layer performance, in terms of storm water retention, shows that the aggregate (stone) drainage layer system performed the best, with the moisture management mat system second, and the geotextile drain layer and reservoir sheet layer systems coming in last. This information is of value in the planning and design of vegetative roof systems since the different types of drainage layer systems have different installation costs and different weights. The different drainage layer systems also seem to be having an impact on plant growth and spread with the test plot with the reservoir sheet layer actually having the poorest plant coverage and plant spread of all areas of the roof studied. Plant growth performance analysis is ongoing, but significant differences have been observed in the third growing season ('13) along the north to south axis, with most species doing better towards the northern end of the roof (in terms of

  9. Saint Joseph's University Institute for Environmental Stewardship

    SciTech Connect

    McCann, Micahel P.; Springer, Clint J.

    2014-06-03

    future climate scenarios is local adaptation and not necessarily genome size as has been hypothesized in the literature. Task B: Installation of an extensive green roof system on the Science Center at Saint Joseph's University for research, research-training and educational outreach activities. An experimental green roof system was designed and installed by an outside contractor (Roofmeadows) on the roof of the Science Center at Saint Joseph's University. The roof system includes four test plots, each with a different drainage system, instrumentation to monitor storm water retention, roof deck temperature, heat flux into and out of the building, rain fall, wind speed and direction, relative humidity and heat emission from the roof system. The vegetative roof was planted with 26 species of plants, distributed throughout the roof area, to assess species/variety growth and coverage characteristics, both in terms of the different drain layer systems, and in terms of the different exposures along the north to south axis of the building. Analysis of the drain layer performance, in terms of storm water retention, shows that the aggregate (stone) drainage layer system performed the best, with the moisture management mat system second, and the geotextile drain layer and reservoir sheet layer systems coming in last. This information is of value in the planning and design of vegetative roof systems since the different types of drainage layer systems have different installation costs and different weights. The different drainage layer systems also seem to be having an impact on plant growth and spread with the test plot with the reservoir sheet layer actually having the poorest plant coverage and plant spread of all areas of the roof studied. Plant growth performance analysis is ongoing, but significant differences have been observed in the third growing season ('13) along the north to south axis, with most species doing better towards the northern end of the roof (in terms of

  10. Diversification of 99Mo/99mTc separation: non–fission reactor production of 99Mo as a strategy for enhancing 99mTc availability.

    PubMed

    Pillai, Maroor R A; Dash, Ashutosh; Knapp, Furn F Russ

    2015-01-01

    This paper discusses the benefits of obtaining (99m)Tc from non-fission reactor-produced low-specific-activity (99)Mo. This scenario is based on establishing a diversified chain of facilities for the distribution of (99m)Tc separated from reactor-produced (99)Mo by (n,γ) activation of natural or enriched Mo. Such facilities have expected lower investments than required for the proposed chain of cyclotrons for the production of (99m)Tc. Facilities can receive and process reactor-irradiated Mo targets then used for extraction of (99m)Tc over a period of 2 wk, with 3 extractions on the same day. Estimates suggest that a center receiving 1.85 TBq (50 Ci) of (99)Mo once every 4 d can provide 1.48-3.33 TBq (40-90 Ci) of (99m)Tc daily. This model can use research reactors operating in the United States to supply current (99)Mo needs by applying natural (nat)Mo targets. (99)Mo production capacity can be enhanced by using (98)Mo-enriched targets. The proposed model reduces the loss of (99)Mo by decay and avoids proliferation as well as waste management issues associated with fission-produced (99)Mo. PMID:25537991

  11. Sister Mary Joseph nodule-A case report with review of literature

    PubMed Central

    Dar, Ishrat Hussain; Kamili, Mqtasid Ahmed; Dar, Showkat Hussain; Kuchaai, Faiz Ahmed

    2009-01-01

    Sister Mary Joseph nodule or Sister Mary Joseph Sign refers to a palpable nodule bulging into the umbilicus as a result of metastasis of a malignant cancer in the pelvis or abdomen. A rare case of Sister Mary Joseph nodule, manifesting as ascites, cachexia and bleeding per rectum, is presented without any primary tumor despite extensive search for the same. PMID:21772912

  12. Reactor

    DOEpatents

    Evans, Robert M.

    1976-10-05

    1. A neutronic reactor having a moderator, coolant tubes traversing the moderator from an inlet end to an outlet end, bodies of material fissionable by neutrons of thermal energy disposed within the coolant tubes, and means for circulating water through said coolant tubes characterized by the improved construction wherein the coolant tubes are constructed of aluminum having an outer diameter of 1.729 inches and a wall thickness of 0.059 inch, and the means for circulating a liquid coolant through the tubes includes a source of water at a pressure of approximately 350 pounds per square inch connected to the inlet end of the tubes, and said construction including a pressure reducing orifice disposed at the inlet ends of the tubes reducing the pressure of the water by approximately 150 pounds per square inch.

  13. The Reaches of Conscience: An Interview with Joseph P. Lash.

    ERIC Educational Resources Information Center

    McCaffrey, Patrick

    1984-01-01

    Few people knew Eleanor Roosevelt as well as author Joseph P. Lash, author of the Pulitzer prize-winning "Eleanor and Franklin." In this interview Lash talks about Mrs. Roosevelt's personal characteristics, her educational theories, the role she played in attracting minorities to the Democratic Party, and FDR's influence on her. (RM)

  14. A Vignette of an American Sporting Sculptor: Joseph D. Brown.

    ERIC Educational Resources Information Center

    Field, David A.

    In this lecture, about sixty of the more important small and large sports sculptures and medals of Professor Joseph D. Brown are discussed and illustrated through the use of 35mm color slides. A brief description of the sculptor's life, interests, and philosophy of sport is also given. (MB)

  15. Joseph v. Brady: Synthesis Reunites What Analysis Has Divided

    ERIC Educational Resources Information Center

    Thompson, Travis

    2012-01-01

    Joseph V. Brady (1922-2011) created behavior-analytic neuroscience and the analytic framework for understanding how the external and internal neurobiological environments and mechanisms interact. Brady's approach offered synthesis as well as analysis. He embraced Findley's approach to constructing multioperant behavioral repertoires that found…

  16. Video from Panel Discussion with Joseph Fraumeni and David Schottenfeld

    Cancer.gov

    Video footage from Panel Discussion with Joseph Fraumeni and David Schottenfeld on Cancer Epidemiology over the Last Half-Century and Thoughts on the Future. The discussion took place on May 11, 2012, when DCEG hosted Dr. Schottenfeld as a Visiting Scholar.

  17. Perils of Accommodation: The Case of Joseph W. Holley

    ERIC Educational Resources Information Center

    O'Brien, Thomas V.

    2007-01-01

    This study examines accommodationism, a tactic of racial uplift used by black school founders and teachers in the Jim Crow South. For founders, accommodationism was a dangerous process of collaboration, resistance, and compromise. The subject under study is Joseph Winthrop Holley. Born in South Carolina, Holley studied in the North at Phillips…

  18. Visions and Re-Visions of Charles Joseph Minard.

    ERIC Educational Resources Information Center

    Friendly, Michael

    2002-01-01

    Describes the contributions of Charles Joseph Minard to statistical graphics, noting the time course of his work and providing background on his famous effort, the flow-map depiction of Napoleon's march on Moscow. Explores some modern re-visions of this famous graphic from an information visualization perspective. (SLD)

  19. 1. Historic American Buildings Survey Joseph Hill, Photographer March 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer March 10, 1936 CAST IRON BALCONY RAIL AND WROUGHT IRON WINDOW RAILING 945 NORTH DEARBORN STREET, CHICAGO - Chicago Ironwork, Judge Carpenter House (Cast Iron Balcony Railing), 945 North Dearborn Street, Chicago, Cook County, IL

  20. Science and Worldviews in the Classroom: Joseph Priestley and Photosynthesis

    ERIC Educational Resources Information Center

    Matthews, Michael R.

    2009-01-01

    This paper elaborates on the life and publications of Joseph Priestley, the eighteenth-century polymath. The paper outlines his particular place in the European Enlightenment; it stresses the importance of philosophy and worldview in his scientific work on pneumatic chemistry, the composition of air, and his discovery of the process of…

  1. 2. Historic American Buildings Survey Joseph Hill, Photographer October 28, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Joseph Hill, Photographer October 28, 1936 #1 DOORWAY MAXIENER HOUSE 104 South Bench Street, Galena, Ill. (Said to be oldest frame house in Galena) - Galena Doorways, Elizabeth Maxiener Cottage, 104 South Bench Street, Galena, Jo Daviess County, IL

  2. Pioneer in Behavioral Pharmacology: A Tribute to Joseph V. Brady

    ERIC Educational Resources Information Center

    Barrett, James E.

    2008-01-01

    The contributions of Joseph V. Brady to behavioral pharmacology span more than 50 years and range from early studies using the Estes-Skinner ("conditioned emotional response") procedure to examine drug effects and various physiological processes in experimental animals to the implementation of mobile methadone treatment services and to small group…

  3. A 48-month extended fuel cycle for the B and W mPower{sup TM} small modular nuclear reactor

    SciTech Connect

    Erighin, M. A.

    2012-07-01

    The B and W mPower{sup TM} reactor is a small, rail-shippable pressurized water reactor (PWR) with an integral once-through steam generator and an electric power output of 150 MW, which is intended to replace aging fossil power plants of similar output. The core is composed of 69 reduced-height, but otherwise standard, PWR assemblies with the familiar 17 x 17 fuel rod array on a 21.5 cm inter-assembly pitch. The B and W mPower core design and cycle management plan, which were performed using the Studsvik core design code suite, follow the pattern of a typical nuclear reactor fuel cycle design and analysis performed by most nuclear fuel management organizations, such as fuel vendors and utilities. However, B and W is offering a core loading and cycle management plan for four years of continuous power operations without refueling and without the hurdles of chemical shim. (authors)

  4. Methanogenic community change in a full-scale UASB reactor operated at a low F/M ratio.

    PubMed

    Kolukirik, M; Ince, O; Ince, B Kasapgil

    2007-06-01

    A full-scale upflow anaerobic sludge blanket (UASB) reactor was investigated in terms of archaeal composition, acetoclastic methanogenic capacity and performance over a 2-year period. Performance of the reactor in terms of COD removal efficiency varied between 60% and 80% at organic loading rates (OLRs) in the range of 2.5-12 kg COD m-3 d-1. The reactor had been operated under a F/M (food to microorganisms) ratio of 0.02-0.03 gCOD gTVS-1 d-1, which is much lower than the typical values reported for similar reactors. According to specific methanogenic activity (SMA) tests the anaerobic sludge was operating at only 12-34% of its potential acetoclastic methanogenic capacity. These results demonstrated that the UASB reactor was under loaded compared to its maximum loading capacity. All other operational parameters had been maintained within their desired ranges. The SMA test and Fluorescence in situ hybridization (FISH) results revealed that a decrease in the acetoclastic methanogenic activity of the UASB sludge from 344 mL CH4 gTVS-1 d-1 to 109 mL CH4 gTVS-1 d-1 coincided with a decrease in the relative abundance of acetoclastic Methanosaeta from 90%+/-1.2 to 79%+/-1.4 of the archaeal population, and an increase in the relative abundance of hydrogenotrophic Methanobacteriales from non-detectable levels to 24%+/-0.7% of the archaeal population during the 2-year operation of the reactor. The relative abundance of archaeal cells within the UASB sludge was in the range of 15-17%. PMID:17558771

  5. Obituary: Joseph Wyan Chamberlain, 1928-2004

    NASA Astrophysics Data System (ADS)

    Hunten, Donald M.

    2004-12-01

    Joseph W. Chamberlain died at home with his family on April 14 2004 after a long illness. He was born August 24, 1928 and raised in Boonville, Missouri, where his father was the doctor. There was no doubt that both Joe and his elder brother Gilbert would also become doctors, but Joe's first class in comparative anatomy at the University of Missouri convinced him that this was not his destiny and he immediately switched to physics and astronomy. He obtained a Masters degree in physics and moved on to the University of Michigan; his advisor was Lawrence Aller and he was also strongly influenced by Leo Goldberg. Early in 1952 he was awarded a PhD and began work at the Air Force Cambridge Research Center where he changed his interests to the upper atmosphere. Among his duties was liaison with research groups at several universities, and I met him when he visited us at the University of Saskatchewan one very cold winter day. He was soon posted to work with Aden Meinel at Yerkes Observatory, where he was added to the faculty and became the leader of the group when Meinel departed to organize the Kitt Peak National Observatory. He himself moved there in 1962 as Associate Director for Space Science; the name of the division was later changed to Planetary Science. He recruited a strong group to work on planetary atmospheres and several group members played important roles in the Mariner 10, Pioneer Venus, Viking, Voyager and Galileo missions. He was elected to the National Academy of Sciences in 1965. As leader of the group he recruited at Kitt Peak, Joe earned the admiration and loyalty of us all. He strongly preferred doing science to his administrative tasks, but he was still effective at the latter. He was considerably bothered that his superiors, especially the managing boards with which he had to deal, did not always meet his high standards. Joe's friends and colleagues felt, and still feel, that he would have been much happier as a member of a teaching faculty, and

  6. Obituary: Joseph Wyan Chamberlain, 1928-2004

    NASA Astrophysics Data System (ADS)

    Hunten, Donald M.

    2004-12-01

    Joseph W. Chamberlain died at home with his family on April 14 2004 after a long illness. He was born August 24, 1928 and raised in Boonville, Missouri, where his father was the doctor. There was no doubt that both Joe and his elder brother Gilbert would also become doctors, but Joe's first class in comparative anatomy at the University of Missouri convinced him that this was not his destiny and he immediately switched to physics and astronomy. He obtained a Masters degree in physics and moved on to the University of Michigan; his advisor was Lawrence Aller and he was also strongly influenced by Leo Goldberg. Early in 1952 he was awarded a PhD and began work at the Air Force Cambridge Research Center where he changed his interests to the upper atmosphere. Among his duties was liaison with research groups at several universities, and I met him when he visited us at the University of Saskatchewan one very cold winter day. He was soon posted to work with Aden Meinel at Yerkes Observatory, where he was added to the faculty and became the leader of the group when Meinel departed to organize the Kitt Peak National Observatory. He himself moved there in 1962 as Associate Director for Space Science; the name of the division was later changed to Planetary Science. He recruited a strong group to work on planetary atmospheres and several group members played important roles in the Mariner 10, Pioneer Venus, Viking, Voyager and Galileo missions. He was elected to the National Academy of Sciences in 1965. As leader of the group he recruited at Kitt Peak, Joe earned the admiration and loyalty of us all. He strongly preferred doing science to his administrative tasks, but he was still effective at the latter. He was considerably bothered that his superiors, especially the managing boards with which he had to deal, did not always meet his high standards. Joe's friends and colleagues felt, and still feel, that he would have been much happier as a member of a teaching faculty, and

  7. Filtered fast neutron irradiation system using Texas A&M University Nuclear Science Center Reactor

    NASA Astrophysics Data System (ADS)

    Jang, S. Y.; Kim, C. H.; Reece, W. D.; Braby, L. A.

    2004-09-01

    A heavily filtered fast neutron irradiation system (FNIS) was developed for a variety of applications, including the study of long-term health effects of fast neutrons by evaluating the biological mechanisms of damage in cultured cells and living animals such as rats or mice. This irradiation system includes an exposure cave made with a lead-bismuth alloy, a cave positioning system, a gamma and neutron monitoring system, a sample transfer system, and interchangeable filters. This system was installed in the irradiation cell of the Texas A&M University Nuclear Science Center Reactor (NSCR). For a realistic modeling of the NSCR, the irradiation cell, and the FNIS, this study used the Monte Carlo N-Particle (MCNP) code and a set of high-temperature ENDF/B-VI continuous neutron cross-section data. Sensitivity analysis was performed to find the characteristics of the FNIS as a function of the thickness of the lead-bismuth alloy. A paired ion chamber system was constructed with a tissue-equivalent plastic (A-150) and propane gas for total dose monitoring and with graphite and argon for gamma dose monitoring. This study, in addition, tested the Monte Carlo modeling of the FNIS system, as well as the performance of the system by comparing the calculated results with experimental measurements using activation foils and paired ion chambers.

  8. Reduced enrichment neutronics evaluation for Texas A and M's TRIGA reactor

    SciTech Connect

    Rajalakshmi, M.J.; Reuscher, J.A. )

    1990-06-01

    The Texas A and M Nuclear Science Center reactor (NSCR) designed by General Atomics (GA) uses a fuel-life improvement program TRIGA fuel element. It is composed of 8.5 wt% uranium in U-ZrH{sub 1.6}-Er fuel with a {sup 235}U enrichment of 70 at.% and 1.5 wt% of erbium. The US Nuclear Regulatory Commission requires that the enrichment not exceed 20 at.% for the next loading, provided the fuel is available. To meet this requirement GA has developed shrouded four-rod clusters using low-enriched U-ZrH{sub 1.6}-Er fuel for TRIGA cores operating at powers up to 2 MW. This fuel contains 20 wt% of uranium with an enrichment of 20 at.% and 0.5 wt% of erbium and a homogeneous mixture of hydrogen moderator. Thermal-hydraulic calculations show the feasibility of operating the NSCR at 2 MW. The objective of this study is to assess the ability of the NSCR to operate at 2 MW using the reduced-enrichment fuel. This study also covers a three-dimensional neutronics analysis of the NSCR core using the new fuel. Results obtained are compared with results obtained with another candidate fuel, BeO-UO{sub 2}-Er.

  9. In praise of Joseph Priestley - the particle physicist!

    NASA Astrophysics Data System (ADS)

    Jones, G. T.

    1991-05-01

    Joseph Priestley (1733 - 1804), known more as a chemist, made important contributions to the evolution of our view of the structure of matter. To commemorate the notorious Birmingham riots of July 1791, during which his house was burnt and his work destroyed, and following which he left England for the United States after three years in London, this article highlights his major contribution to what we now call particle physics

  10. Astronaut Paul Weitz gets physical examination from Astronaut Joseph Kerwin

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Astronaut Paul J. Weitz, Skylab 2 pilot, gets a physical examination by a fellow crewman during the 28-day Skylab 2 mission. Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot and a doctor of medicine, uses a stethoscope to check the Weitz's heartbeat. They are in the Orbital Workshop crew quarters of the Skylab 1 and 2 space station in Earth orbit. This photograph was taken by Charles Conrad Jr., Skylab 2 commander.

  11. Extension of RAPTOR-M3G to r-θ-z Geometry for Use in Reactor Dosimetry Applications

    NASA Astrophysics Data System (ADS)

    Hunter, Melissa A.; Longoni, Gianluca; Anderson, Stanwood L.

    2009-08-01

    The RAPTOR-M3G (RApid Parallel Transport Of Radiation - Multiple 3-D Geometries) is a new deterministic radiation transport code that was originally developed for x-y-z geometry. The development of the r-θ-z version of RAPTOR-M3G and its application to determine ex-vessel neutron dosimetry responses in the cavity of a typical 2-loop pressurized water reactor is presented. The neutron dosimetry responses determined from RAPTOR-M3G and TORT 3-D r-θ-z calculations are compared to actual measured responses.

  12. Prediction of Liquid Sodium Flow Rate through the Core of the IBR-2M Reactor Using Nonlinear Autoregressive Neural Networks

    NASA Astrophysics Data System (ADS)

    Ososkov, G.; Pepelyshev, Yu.; Tsogtsaikhan, Ts.

    2016-02-01

    This paper presents an artificial neural network method for long-term prediction of liquid sodium flow rate through the core of the IBR-2M reactor. The nonlinear autoregressive neural network (NAR) with local feedback connection has been considered as the most appropriate tool for such a prediction. The predicted results were compared with experimental values. NAR model predicts slow changes of liquid sodium flow rate up to two days with an error less than 5%.

  13. The first critical experiment with a LEU Russian fuel IRT-4M at the training reactor VR-1

    SciTech Connect

    Frybort, Jan

    2008-07-15

    A critical experiment is a standard part of training of students at the Training Reactor VR-1 operated within the Faculty of Nuclear Sciences and Physical Engineering at the Czech Technical University in Prague. In autumn 2005 the HEU fuel IRT-3M with enrichment 36 % {sup 235}U was replaced by the LEU fuel IRT-4M with enrichment 19.7 % {sup 235}U. The fuel replacement at the VR-1 Reactor is a part of an international program RERTR. This Paper presents basic information about preparation for the fuel replacement and approaching of the first critical state with the new zone configuration C1 which replaced B1 core with the old IRT-3M fuel. The whole process was carried out according to the Czech law and the relevant international recommendations. The experience with the VR-1 operation confirms the assumption that the C1 core configuration will be suitable from the point of view of the reactivity balance for the long term safe operation of the Training Reactor VR-1. (author)

  14. Advanced neutron irradiation system using Texas A&M University Nuclear Science Center Reactor

    NASA Astrophysics Data System (ADS)

    Jang, Si Young

    A heavily filtered fast neutron irradiation system (FNIS) was developed for a variety of applications, including the study of long-term health effects of fast neutrons by evaluating the biological mechanisms of damage in cultured cells and living animals such as rats or mice. This irradiation system includes an exposure cave made with a lead-bismuth alloy, a cave positioning system, a gamma and neutron monitoring system, a sample transfer system, and interchangeable filters. This system was installed in the irradiation cell of the Texas A&M University Nuclear Science Center Reactor (NSCR). By increasing the thickness of the lead-bismuth alloy, the neutron spectra were shifted into lower energies by the scattering interactions of fast neutrons with the alloy. It is possible, therefore, by changing the alloy thickness, to produce distinctly different dose weighted neutron spectra inside the exposure cave of the FNIS. The calculated neutron spectra showed close agreement with the results of activation foil measurements, unfolded by SAND-II close to the cell window. However, there was a considerable less agreement for locations far away from the cell window. Even though the magnitude of values such as neutron flux and tissue kerma rates in air differed, the weighted average neutron energies showed close agreement between the MCNP and SAND-II since the normalized neutron spectra were in a good agreement each other. A paired ion chamber system was constructed, one with a tissue equivalent plastic (A-150) and propane gas for total dose monitoring, and another with graphite and argon for photon dose monitoring. Using the pair of detectors, the neutron to gamma ratio can be inferred. With the 20 cm-thick FNIS, the absorbed dose rates of neutrons measured with the paired ion chamber method and calculated with the SAND-II results were 13.7 +/- 0.02 Gy/min and 15.5 Gy/min, respectively. The absorbed dose rate of photons and the gamma contribution to total dose were 6.7 x 10

  15. Reactor performance of a 750 m(3) anaerobic digestion plant: varied substrate input conditions impacting methanogenic community.

    PubMed

    Wagner, Andreas Otto; Malin, Cornelia; Lins, Philipp; Gstraunthaler, Gudrun; Illmer, Paul

    2014-10-01

    A 750 m(3) anaerobic digester was studied over a half year period including a shift from good reactor performance to a reduced one. Various abiotic parameters like volatile fatty acids (VFA) (formic-, acetic-, propionic-, (iso-)butyric-, (iso-)valeric-, lactic acid), total C, total N, NH4 -N, and total proteins, as well as the organic matter content and dry mass were determined. In addition several process parameters such as temperature, pH, retention time and input of substrate and the concentrations of CH4, H2, CO2 and H2S within the reactor were monitored continuously. The present study aimed at the investigation of the abundance of acetogens and total cell numbers and the microbial methanogenic community as derived from PCR-dHPLC analysis in order to put it into context with the determined abiotic parameters. An influence of substrate quantity on the efficiency of the anaerobic digestion process was found as well as a shift from a hydrogenotrophic in times of good reactor performance towards an acetoclastic dominated methanogenic community in times of reduced reactor performance. After the change in substrate conditions it took the methano-archaeal community about 5-6 weeks to be affected but then changes occurred quickly. PMID:24727280

  16. An extended conventional fuel cycle for the B and W mPower{sup TM} small modular nuclear reactor

    SciTech Connect

    Scarangella, M. J.

    2012-07-01

    The B and W mPower{sup TM} reactor is a small pressurized water reactor (PWR) with an integral once-through steam generator and a thermal output of about 500 MW; it is intended to replace aging fossil power plants of similar output. The core is composed of 69 reduced-height PWR assemblies with the familiar 17 x 17 fuel rod array. The Babcock and Wilcox Company (B and W) is offering a core loading and cycle management plan for a four-year cycle based on its presumed attractiveness to potential customers. This option is a once-through fuel cycle in which the entire core is discharged and replaced after four years. In addition, a conventional fuel utilization strategy, employing a periodic partial reload and shuffle, was developed as an alternative to the four-year once-through fuel cycle. This study, which was performed using the Studsvik core design code suite, is a typical multi-cycle projection analysis of the type performed by most fuel management organizations such as fuel vendors and utilities. In the industry, the results of such projections are used by the financial arms of these organizations to assist in making long-term decisions. In the case of the B and W mPower reactor, this analysis demonstrates flexibility for customers who consider the once-through fuel cycle unacceptable from a fuel utilization standpoint. As expected, when compared to the once-through concept, reloads of the B and W mPower reactor will achieve higher batch average discharge exposure, will have adequate shut-down margin, and will have a relatively flat hot excess reactivity trend at the expense of slightly increased peaking. (authors)

  17. Professor Joseph Warren Horton (1889-1967): biological engineer.

    PubMed

    Zeitlin, Gerald L

    2005-02-01

    Joseph Warren Horton graduated with a degree in electrical engineering from the Massachusetts Institute of Technology (MIT) in 1914. He became involved in the early development of electrical measurement devices, televised image transmission, and the detection of underwater sound transmission. In the mid-1930s he was appointed the first leader of the newly created Department of Biological Engineering at MIT and in this position he made major contributions to the application of physics to human physiology, in particular by increasing the safety of explosive inhalational anaesthetic agents. PMID:15682231

  18. Joseph Harris of Trevecka: Scientist, Artisan, Servant of the Crown

    NASA Astrophysics Data System (ADS)

    Griffiths, M.

    2012-01-01

    A major goal of natural philosophy in the early eighteenth century was the search for accurate positional longitude. This quest demanded the most precise instruments and the most meticulous observations in astronomy and geophysics. Joseph Harris strode across these disciplines making a valuable contribution to the studies of astronomy, navigation, horology and magnetic variation. He later served his country by standardising weights and measures of coinage as Assay Master at the Royal Mint. Yet his prowess is little known or acknowledged. This paper describes and examines his life and roles.

  19. Joseph V. Brady: Synthesis Reunites What Analysis Has Divided

    PubMed Central

    Thompson, Travis

    2012-01-01

    Joseph V. Brady (1922–2011) created behavior-analytic neuroscience and the analytic framework for understanding how the external and internal neurobiological environments and mechanisms interact. Brady's approach offered synthesis as well as analysis. He embraced Findley's approach to constructing multioperant behavioral repertoires that found their way into designing environments for astronauts as well as studying drug effects on human social behavior in microenvironments. Brady created translational neurobehavioral science before such a concept existed. One of his most lasting contributions was developing a framework for ethical decision making to protect the rights of the people who participate in scientific research. PMID:23450040

  20. Joseph Rotblat, the bomb and anomalies from his archive.

    PubMed

    Underwood, Martin C

    2013-06-01

    Professor Sir Joseph Rotblat made significant contributions to nuclear physics and worked on the development of the atomic bomb. He walked out of the Manhattan Project after working there for less than a year, the only scientist to do so. Rotblat gave a comprehensive account of his time at Los Alamos. His Archive is now becoming available and papers contained therein are inconsistent with some aspects of his account. The reasons as to how such anomalies and contradictions could occur are considered. PMID:22190230

  1. A CFD M&S PROCESS FOR FAST REACTOR FUEL ASSEMBLIES

    SciTech Connect

    Kurt D. Hamman; Ray A. Berry

    2008-09-01

    A CFD modeling and simulation process for large-scale problems using an arbitrary fast reactor fuel assembly design was evaluated. Three dimensional flow distributions of sodium for several fast reactor fuel assembly pin spacing configurations were simulated on high performance computers using commercial CFD software. This research focused on 19-pin fuel assembly “benchmark” geometry, similar in design to the Advanced Burner Test Reactor, where each pin is separated by helical wire-wrap spacers. Several two-equation turbulence models including the k-e and SST (Menter) k-? were evaluated. Considerable effort was taken to resolve the momentum boundary layer, so as to eliminate the need for wall functions and reduce computational uncertainty. High performance computers were required to generate the hybrid meshes needed to predict secondary flows created by the wire-wrap spacers; computational meshes ranging from 65 to 85 million elements were common. A general validation methodology was followed, including mesh refinement and comparison of numerical results with empirical correlations. Predictions for velocity, temperature, and pressure distribution are shown. The uncertainty of numerical models, importance of high fidelity experimental data, and the challenges associated with simulating and validating large production-type problems are presented.

  2. Reactor Dosimetry Applications Using RAPTOR-M3G:. a New Parallel 3-D Radiation Transport Code

    NASA Astrophysics Data System (ADS)

    Longoni, Gianluca; Anderson, Stanwood L.

    2009-08-01

    The numerical solution of the Linearized Boltzmann Equation (LBE) via the Discrete Ordinates method (SN) requires extensive computational resources for large 3-D neutron and gamma transport applications due to the concurrent discretization of the angular, spatial, and energy domains. This paper will discuss the development RAPTOR-M3G (RApid Parallel Transport Of Radiation - Multiple 3D Geometries), a new 3-D parallel radiation transport code, and its application to the calculation of ex-vessel neutron dosimetry responses in the cavity of a commercial 2-loop Pressurized Water Reactor (PWR). RAPTOR-M3G is based domain decomposition algorithms, where the spatial and angular domains are allocated and processed on multi-processor computer architectures. As compared to traditional single-processor applications, this approach reduces the computational load as well as the memory requirement per processor, yielding an efficient solution methodology for large 3-D problems. Measured neutron dosimetry responses in the reactor cavity air gap will be compared to the RAPTOR-M3G predictions. This paper is organized as follows: Section 1 discusses the RAPTOR-M3G methodology; Section 2 describes the 2-loop PWR model and the numerical results obtained. Section 3 addresses the parallel performance of the code, and Section 4 concludes this paper with final remarks and future work.

  3. Operating characteristic analysis of a 400 mH class HTS DC reactor in connection with a laboratory scale LCC type HVDC system

    NASA Astrophysics Data System (ADS)

    Kim, Sung-Kyu; Kim, Kwangmin; Park, Minwon; Yu, In-Keun; Lee, Sangjin

    2015-11-01

    High temperature superconducting (HTS) devices are being developed due to their advantages. Most line commutated converter based high voltage direct current (HVDC) transmission systems for long-distance transmission require large inductance of DC reactor; however, generally, copper-based reactors cause a lot of electrical losses during the system operation. This is driving researchers to develop a new type of DC reactor using HTS wire. The authors have developed a 400 mH class HTS DC reactor and a laboratory scale test-bed for line-commutated converter type HVDC system and applied the HTS DC reactor to the HVDC system to investigate their operating characteristics. The 400 mH class HTS DC reactor is designed using a toroid type magnet. The HVDC system is designed in the form of a mono-pole system with thyristor-based 12-pulse power converters. In this paper, the investigation results of the HTS DC reactor in connection with the HVDC system are described. The operating characteristics of the HTS DC reactor are analyzed under various operating conditions of the system. Through the results, applicability of an HTS DC reactor in an HVDC system is discussed in detail.

  4. 78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF TRANSPORTATION Surface Transportation Board Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen... Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and Richard Kosiba...

  5. Joseph Campbell, Jung, Anne Tyler, and "The Cards": The Spiritual Journey in "Searching for Caleb."

    ERIC Educational Resources Information Center

    Thomson, Karen M.

    Joseph Campbell, Carl Jung, and Anne Tyler have all dealt with spiritual journeys and card reading in their writings. In his book "Tarot Revelations," Joseph Campbell discusses his first association with tarot cards, dating from 1943, when he was introduced to the symoblism of playing cards by his friend and mentor, Heinrich Zimmer. Carl Jung was…

  6. Leader and Spokesman for a People in Exile: Chief Joseph and the Nez Perce

    ERIC Educational Resources Information Center

    Jain, Samvit

    2009-01-01

    This article discusses Chief Joseph's surrender that marked the beginning of his diplomatic stand for justice in Indian Territory, where his tribe was forcibly exiled in accordance with American Indian policy of the time. Joseph battled for the repatriation of the Nez Perce through protests and other legal means, winning the support of the growing…

  7. 77 FR 3797 - Joseph Deluca, D.O.; Dismissal of Proceeding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Joseph Deluca, D.O.; Dismissal of Proceeding On July 16, 2010, the Deputy Assistant... Joseph Deluca, D.O. (Registrant), of Coral Springs, Florida. The Show Cause Order proposed the...

  8. 78 FR 66801 - Norfolk Southern Railway Company-Abandonment Exemption-in St. Joseph County, Ind.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ... Surface Transportation Board Norfolk Southern Railway Company--Abandonment Exemption--in St. Joseph County... 1152 subpart F-Exempt Abandonments to abandon a total of approximately 1.5 miles of rail line located in the City of ] South Bend, St. Joseph County, Ind., extending easterly from milepost PY 1.90...

  9. Project of the new multifunctional reflectometer GRAINS with horizontal sample plane at the IBR-2M pulsed reactor in Dubna

    NASA Astrophysics Data System (ADS)

    Avdeev, M. V.; Bodnarchuk, V. I.; Lauter-Pasyuk, V. V.; Lauter, H.; Aksenov, V. L.; Yaradaikin, S. P.; Ulyanov, V. A.; Trounov, V. A.; Kalinin, S. I.

    2010-11-01

    The new multifunctional reflectometer GRAINS is under construction at the modernized high flux IBR-2 pulsed reactor (IBR-2M) of the FLNP JINR (Dubna, Russia). The principal feature of this reflectometer, the horizontal sample plane (or vertical scattering plane), enables the study of liquid-containing interfaces. The reflectometer will operate in the time-of-flight regime with constant sample illumination during measurements. The important advantage is the constant angular resolution with unvaried background. The additional modes of the GRAINS reflectometer comprise (1) off-specular scattering and GISANS, which are measured simultaneously in the TOF regime at a 2D position-sensitive detector; (2) angular encoding in the horizontal plane, which is provided by a Larmor precession region limited by current sheets in front of the sample; (3) 3D polarimetry in reflection, which is provided by a Larmor precession region around the sample position. The design of the reflectometer is optimised to take better advantage of an exceptionally broad wavelength band of the new cold moderator at the IBR-2M. The set-up will open up principally new possibilities for investigations in the field of interface nano-science at the IBR-2M reactor.

  10. Selection and identification of a bacterial community able to degrade and detoxify m-nitrophenol in continuous biofilm reactors.

    PubMed

    González, Ana J; Fortunato, María S; Papalia, Mariana; Radice, Marcela; Gutkind, Gabriel; Magdaleno, Anahí; Gallego, Alfredo; Korol, Sonia E

    2015-12-01

    Nitroaromatics are widely used for industrial purposes and constitute a group of compounds of environmental concern because of their persistence and toxic properties. Biological processes used for decontamination of nitroaromatic-polluted sources have then attracted worldwide attention. In the present investigation m-nitrophenol (MNP) biodegradation was studied in batch and continuous reactors. A bacterial community able to degrade the compound was first selected from a polluted freshwater stream and the isolates were identified by the analysis of the 16S rRNA gene sequence. The bacterial community was then used in biodegradation assays. Batch experiments were conducted in a 2L aerobic microfermentor at 28 °C and with agitation (200 rpm). The influence of abiotic factors in the biodegradation process in batch reactors, such as initial concentration of the compound and initial pH of the medium, was also studied. Continuous degradation of MNP was performed in an aerobic up-flow fixed-bed biofilm reactor. The biodegradation process was evaluated by determining MNP and ammonium concentrations and chemical oxygen demand (COD). Detoxification was assessed by Vibrio fischeri and Pseudokirchneriella subcapitata toxicity tests. Under batch conditions the bacterial community was able to degrade 0.72 mM of MNP in 32 h, with efficiencies higher than 99.9% and 89.0% of MNP and COD removals respectively and with concomitant release of ammonium. When the initial MNP concentration increased to 1.08 and 1.44 mM MNP the biodegradation process was accomplished in 40 and 44 h, respectively. No biodegradation of the compound was observed at higher concentrations. The community was also able to degrade 0.72 mM of the compound at pH 5, 7 and 9. In the continuous process biodegradation efficiency reached 99.5% and 96.8% of MNP and COD removal respectively. The maximum MNP removal rate was 37.9 gm(-3) day(-1). Toxicity was not detected after the biodegradation process. PMID:26283285

  11. Criticality calculations for the VR-1 reactor with IRT-3M-HEU fuel and IRT-4MLEU fuel.

    SciTech Connect

    Hanan, N. A.; Matos, J. E.

    2007-01-17

    At The request of the Czech Technical University in Prague, ANL has performed independent verification calculations using the MCNP Monte Carlo code for three core configurations of the VR-1 reactor: a current core configuration B1 with HEU (36%) IRT-3M fuel assemblies and planned core configurations C1 and C2 with LEU (19.7%) IRT-4M fuel assemblies. Details of these configurations were provided to ANL by CTU. For core configuration B1, criticality calculations were performed for two sets of control rod positions provided to ANL by CTU. For core configurations C1 and C2, criticality calculations were done for cases with all control rods at the top positions, all control rods at the bottom positions, and two critical states of the reactor for different control rod positions. In addition, sensitivity studies for variation of the {sup 235}U mass in each fuel assembly and variation of the fuel meat and cladding thicknesses in each of the fuel tubes were done for the C1 core configuration. Finally the reactivity worth of the individual control rods was calculated for the B1, C1, and C2 core configurations.

  12. Integral cross section measurement of the U 235 ( n , n ' ) U 235 m reaction in a pulsed reactor

    DOE PAGESBeta

    Bélier, G.; Bond, E. M.; Vieira, D. J.; Authier, N.; Becker, J. A.; Hyneck, D.; Jacquet, X.; Jansen, Y.; Legendre, J.; Macri, R.; et al

    2015-04-08

    The integral measurement of the neutron inelastic cross section leading to the 26-minute half-life 235mU isomer in a fission-like neutron spectrum is presented. The experiment has been performed at a pulsed reactor, where the internal conversion decay of the isomer was measured using a dedicated electron detector after activation. The sample preparation, efficiency measurement, irradiation, radiochemistry purification, and isomer decay measurement will be presented. We determined the integral cross section for the ²³⁵U(n,n')235mU reaction to be 1.00±0.13b. This result supports an evaluation performed with TALYS-1.4 code with respect to the isomer excitation as well as the total neutron inelastic scatteringmore » cross section.« less

  13. Science and Worldviews in the Classroom: Joseph Priestley and Photosynthesis

    NASA Astrophysics Data System (ADS)

    Matthews, Michael R.

    2009-06-01

    This paper elaborates on the life and publications of Joseph Priestley, the eighteenth-century polymath. The paper outlines his particular place in the European Enlightenment; it stresses the importance of philosophy and worldview in his scientific work on pneumatic chemistry, the composition of air, and his discovery of the process of photosynthesis (or the ‘restoration of air’ as it was called at the time); finally the paper indicates ways in which Priestley’s work on photosynthesis can be utilised in the school classroom to advance the understanding of scientific subject matter, to promote an understanding of the nature of scientific procedure and methodology, and finally to evaluate some basic tenets of the European Enlightenment that Priestley so passionately advocated.

  14. Photographic copy of photograph, Joseph Yolo, photographer, 1936 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph, Joseph Yolo, photographer, 1936 (original print located at U.S. Bureau of Reclamation Upper Columbia Area Office, Yakima, Washington). "WAHT A GOVERNMENT CANAL AND AN ASSURED WATER SUPPLY WILL DO IN A DESERT AREA IS SHOWN IN THIS AIR VIEW OF A SECTION OF THE YAKIMA FEDERAL RECLAMATION PROJECT IN CENTRAL WASHINGTON. THE MAIN CANAL IS SEEN RUNNING DOWN THE MIDDLE OF THE VALLEY WITH PATCHES OF ORCHARDS AND FIELDS ON EITHER SIDE, BUT ABOVE THE CANAL LINE THE SAGE BRUSH DESERT REMAINS, AS CAN BE SEEN ON THE LEFT. THE YAKIMA PROJECT SUPPORTS MORE THAN 110,000 PEOPLE IN A TERRITORY WHICH WAS DESERT 35 YEARS AGO. MANY OF THE ORIGINAL SETTLERS WHO CAME, LIKE THOSE WHO ARE NOW SETTLING ON THE VALE PROJECT, TO BREAK THE RAW DESERT LAND, ARE STILL LIVING ON THESE NEATLY CHECKERBOARDED FARMS" - Kachess Dam, Kachess River, 1.5 miles north of Interstate 90, Easton, Kittitas County, WA

  15. Science Advisor and Applied Physicist: Joseph Henry Serves His Country

    NASA Astrophysics Data System (ADS)

    Rothenberg, Marc

    1997-04-01

    When Joseph Henry accepted the postion of secretary of the Smithsonian in 1846, his career changed radically. Although he never ceased thinking of himself as a research scientist and educator, thereafter his chief roles were those of science administrator and advisor to both the executive and legislative branches of the federal government for both science and technology. His effectiveness as an advocate became more important than his skill as an experimental physicist. Even when he entered the laboratory, his role had changed. No longer was he concerned with basic research. As a member of various government boards and committees, Henry spent the last three decades of his life concerned with the application of fundamental knowledge for the improvement of the human condition. This paper will discuss Henry's service on behalf of his country.

  16. Joseph Lister: his contributions to early experimental physiology

    PubMed Central

    Howard, Edward R.

    2013-01-01

    Joseph Lister (1827–1912) acquired a lifelong interest in histology and experimental physiology while a student at University College London between 1848 and 1852. His first two publications in 1853 were histological studies of the contractile tissue of the iris and the skin. Studies of inflammation in 1855 progressed to experiments on the nervous control of arteries, using techniques of peripheral nerve division, spinal cord section and needle stimulation of the brain. This interest in nervous mechanisms led to innovative experiments on gut motility and the autonomic nervous system, from which he inferred that sympathetic nerve control was mediated via intrinsic neuronal plexuses in the gut wall, a mode of action confirmed 100 years later, in 1964–65. It is not generally known that Lister was elected FRS for this early experimental work and that his early commitment to experimental science and microscopy was the background to his later work on the development of surgical antisepsis.

  17. Joseph Gurney Barclay and the 1860 10-inch Cooke refractor

    NASA Astrophysics Data System (ADS)

    Barclay, C. E.

    2006-12-01

    Joseph Gurney Barclay (1816-1898) was a partner in the banking firm of Barclay, Bevan & Co. He was, like his grandfather, Robert Barclay of Clapham, a keen Astronomer who observed regularly at his home Knotts Green House in Leyton, Essex, England, and he was a frequent contributor to the Monthly Notices of the Royal Astronomical Society. Employing professional astronomers, he made many original observations, especially following the acquisition of a 10-inch Cooke refractor in 1860. Gifted to the Radcliffe Observatory, Oxford in 1885, the 'Barclay Equatorial' continued in professional use until 1935 when it was removed to Marlborough College in Wiltshire, England, where it is now in full computerized use following complete restoration.

  18. Joseph Rotblat: Moral Dilemmas and the Manhattan Project

    NASA Astrophysics Data System (ADS)

    Veys, Lucy

    2013-12-01

    John Fitzgerald Kennedy famously said, "One man can make a difference and every man should try."1 Joseph Rotblat (1908-2005) was the quintessence of Kennedy's conviction. He was the only scientist who left Los Alamos after it transpired that the atomic bomb being developed there was intended for use against adversaries other than Nazi Germany. I explore Rotblat's early research in Warsaw and Liverpool, which established his reputation as a highly capable experimental physicist, and which led him to join the Manhattan Project at Los Alamos in 1944. I examine his motivation for resigning from the project in 1945, and the unwillingness of his fellow scientists to follow suit, which draws attention to the continuing discourse on the responsibility of scientists for the consequences of their research.

  19. Pierre-Joseph Macquer: Chemistry in the French Enlightenment.

    PubMed

    Lehman, Christine

    2014-01-01

    Despite recent studies of chemistry courses and of academic research at the beginning of the eighteenth century, the perception of chemistry in the French Enlightenment has often been overshadowed by Lavoisier's works. This article proposes three specific case studies selected from Pierre Joseph Macquer's (1718-84) rich career to show the continuous evolution of chemistry throughout the century: medicinal chemistry through the application of the Comte de La Garaye's metallic salt solutions, the emergence of industrial chemistry through a few of Macquer's evaluations at the Bureau du Commerce, and finally communal academic research through the experiments on diamonds using Tschirnhaus's lens. These examples attempt to illustrate the innovative, creative, dynamic, multicultural, and multifaceted chemistry of the Enlightenment. PMID:26103758

  20. Joseph Lister and the performance of antiseptic surgery

    PubMed Central

    Worboys, Michael

    2013-01-01

    This article highlights a neglected feature of Joseph Lister's work, namely how, in addition to promoting germ theories and the principles of the antiseptic system, he also devoted much time and effort to communicating the performative aspects of antisepsis and of the many other surgical innovations that he developed. Attention to ‘detail’ and striving for ‘improvement’ were crucial to Listerian practice, and he sought to convey his credo in three main ways: first, his publications aimed at ‘bringing the subject out in the same sort of way as it had been worked out by himself’; second, he set out strict protocols and information on materials and methods, yet also encouraged surgeons to improvise; and third, he made himself an exemplar of a new form of professionalism, which made constancy and vigilance in practice a moral duty for surgeons. PMID:24686323

  1. Joseph Rotblat and the moral responsibilities of the scientist.

    PubMed

    Underwood, Martin Clifford

    2009-06-01

    Professor Sir Joseph Rotblat was one of the most distinguished scientists and peace campaigners of the post second world war period. He made significant contributions to nuclear physics and worked on the development of the atomic bomb. He then became one of the world's leading researchers into the biological effects of radiation. His life from the early 1950s until his death in August 2005 was devoted to the abolition of nuclear weapons and peace. For this he was awarded the Nobel Peace Prize, together with Pugwash Conferences on Science and World Affairs (that he helped found) in 1995. His work in this area ranked with that of Albert Einstein and Bertrand Russell and this article is an attempt to summarise his life, achievements, but in particular outline his views on the moral responsibilities of the scientist. He is a towering intellectual figure and his contributions to mankind should be better known and more widely understood. PMID:19247813

  2. Application programming interface document for the modernized Transient Reactor Analysis Code (TRAC-M)

    SciTech Connect

    Mahaffy, J.; Boyack, B.E.; Steinke, R.G.

    1998-05-01

    The objective of this document is to ease the task of adding new system components to the Transient Reactor Analysis Code (TRAC) or altering old ones. Sufficient information is provided to permit replacement or modification of physical models and correlations. Within TRAC, information is passed at two levels. At the upper level, information is passed by system-wide and component-specific data modules at and above the level of component subroutines. At the lower level, information is passed through a combination of module-based data structures and argument lists. This document describes the basic mechanics involved in the flow of information within the code. The discussion of interfaces in the body of this document has been kept to a general level to highlight key considerations. The appendices cover instructions for obtaining a detailed list of variables used to communicate in each subprogram, definitions and locations of key variables, and proposed improvements to intercomponent interfaces that are not available in the first level of code modernization.

  3. Future technological tests on large-scale mock-ups of ITER blanket modules at IVV-2M reactor

    SciTech Connect

    Zyrianov, A.P.; Tokarev, V.I.; Zlokazov, S.B.

    1994-12-31

    A multisection core of water-cooled water-moderated reactor IVV-2M facilities testing of large scale mock-ups of ITER breeder blanket modules, the reactor arrangement in a building provides a maximum close position of tritium {open_quotes}in-pile{close_quotes} measurement station {open_quotes}RITM{close_quotes} to the core (in-pile testing of tritium producing mock-ups). Mock-ups of ceramic and liquid metal blankets are planned to be tested complying the following requirements: mock-up dimensions maximum close to those of ITER, distributions of nuclear power density, temperature fields, tritium release modes at continuous helium purging, provision of cyclic neutron and thermal loading variations. Variants of location of large ({approximately}150x200 mm) mock-up of ceramic blanket and a submerged loop facility containing liquid lithium and a vanadium alloy as a structure material are described. A technological scheme of {open_quotes}RITM{close_quotes} measurement station to study tritium system operation modes are presented.

  4. 1. Historic American Buildings Survey Joseph Hill, Photographer August 10th, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer August 10th, 1936 (Copied from small photo taken by survey members) OLD APARTMENT HOUSE - Jansonist Colony, Old Apartment House, Main Street, Bishop Hill, Henry County, IL

  5. School Public Relations and the Principalship: An Interview with Joseph Murphy.

    ERIC Educational Resources Information Center

    Sweetland, Scott R.; Cybulski, Timonty G.

    2002-01-01

    Interview with Joseph Murphy, professor and head of the Ohio Principals Leadership Academy at The Ohio State University. Murphy answers questions about principal leadership, administrator preparation, and school public relations. (PKP)

  6. Joseph's Story: A Case Study of Late-Onset Necrotizing Enterocolitis From Early Birth to Recovery.

    PubMed

    Gephart, Sheila M; Martin, Laura B; Kijewski, Amy; Johnson, Scott R

    2015-01-01

    Although necrotizing enterocolitis (NEC) is often catastrophic among premature infants, most cases occur in the first month after birth. This case study presents Joseph's story about a 24-week surviving twin who developed severe NEC at 5 months of age just days before he was to go home. The purpose of this case study report is to place Joseph and his parents' experience in the context of what is known about NEC risk factors, clinical presentation, and treatment, and then to offer recommendations to healthcare professionals to support families from NEC diagnosis to recovery. Now 5 years old, Joseph continues to manage consequences of NEC including deafness, developmental delay, multiple food allergies, and recurrent gastrointestinal challenges from short gut syndrome. Although NEC struck late and kept Joseph in the neonatal intensive care unit for 228 days, its consequences remain with this resilient child and his family. PMID:26505849

  7. Characterization of Neutron and Gamma Dose in the Irradiation Cell of Texas A and M University Research Reactor

    SciTech Connect

    Vasudevan, Latha; Reece, Warren D.; Chirayath, Sunil S.; Aghara, Sukesh

    2011-07-01

    The Monte Carlo N-Particle (MCNP) code was used to develop a three dimensional computational model of the Texas A and M University Nuclear Science Center Reactor (NSCR) operating against the irradiation (dry cell) at steady state thermal power of 1 MW. The geometry of the NSCR core and the dry cell were modeled in detail. NSCR is used for a wide variety of experiments that utilizes the dry cell for neutron as well as gamma irradiation of samples. Information on the neutron and gamma radiation environment inside the dry cell is required to facilitate irradiation of samples. This paper presents the computed neutron flux, neutron and gamma dose rate, and foil reaction rates in the dry cell, obtained through MCNP5 simulations of the NSCR core. The neutron flux was measured using foil activation method and the reaction rates obtained from {sup 197}Au(n,{gamma}){sup 198}Au and {sup 54}Fe(n,p){sup 54}Mn were compared with the model and they showed agreement within {approx} 20%. The gamma dose rate at selected locations inside the dry cell was measured using radiochromic films and the results indicate slightly higher dose rates than predicted from the model. This is because the model calculated only prompt gamma dose rates during reactor operation while the radiochromic films measured gammas from activation products and fission product decayed gammas. The model was also used to calculate the neutron energy spectra for the energy range from 0.001 eV- 20 MeV. (authors)

  8. Moths on the Flatbed Scanner: The Art of Joseph Scheer

    PubMed Central

    Buchmann, Stephen L.

    2011-01-01

    During the past decade a few artists and even fewer entomologists discovered flatbed scanning technology, using extreme resolution graphical arts scanners for acquiring high magnification digital images of plants, animals and inanimate objects. They are not just for trip receipts anymore. The special attributes of certain scanners, to image thick objects is discussed along with the technical features of the scanners including magnification, color depth and shadow detail. The work of pioneering scanner artist, Joseph Scheer from New York's Alfred University is highlighted. Representative flatbed-scanned images of moths are illustrated along with techniques to produce them. Collecting and preparing moths, and other objects, for scanning are described. Highlights of the Fulbright sabbatical year of professor Scheer in Arizona and Sonora, Mexico are presented, along with comments on moths in science, folklore, art and pop culture. The use of flatbed scanners is offered as a relatively new method for visualizing small objects while acquiring large files for creating archival inkjet prints for display and sale. PMID:26467835

  9. Strabismus and Micro-Opsoclonus in Machado-Joseph Disease.

    PubMed

    Ghasia, Fatema F; Wilmot, George; Ahmed, Anwar; Shaikh, Aasef G

    2016-08-01

    We describe novel deficits of gaze holding and ocular alignment in patients with spinocerebellar ataxia type 3, also known as Machado-Joseph disease (MJD). Twelve MJD patients were studied. Clinical assessments and quantitative ocular alignment measures were performed. Eye movements were quantitatively assessed with corneal curvature tracker and video-oculography. Strabismus was seen in ten MJD patients. Four patients had mild to moderate intermittent exotropia, three had esotropia, one had skew deviation, one had hypotropia, and one patient had moderate exophoria. Three strabismic patients had V-pattern. Near point of convergence was normal in two out of three patients with exotropia. Gaze holding deficits were also common. Eight patients had gaze-evoked nystagmus, and five had micro-opsoclonus. Other ocular motor deficits included saccadic dysmetria in eight patients, whereas all had saccadic interruption of smooth pursuit. Strabismus and micro-opsoclonus are common in MJD. Coexisting ophthalmoplegia or vergence abnormalities in our patients with exotropia that comprised 50 % of the cohort could not explain the type of strabismus in our patients. Therefore, it is possible that involvement of the brainstem, the deep cerebellar nuclei, and the superior cerebellar peduncle are the physiological basis for exotropia in these patients. Micro-opsoclonus was also common in MJD. Brainstem and deep cerebellar nuclei lesion also explains micro-opsoclonus, whereas brainstem deficits can describe slow saccades seen in our patients with MJD. PMID:26306823

  10. The way of sex: Joseph Needham and Jolan Chang.

    PubMed

    Rocha, Leon Antonio

    2012-09-01

    This paper analyses the understandings of Daoist alchemy and Chinese sexuality of Joseph Needham and his friend and correspondent, the Chinese-Swedish writer Jolan Chang (Chang Chung-lan, 1917-2002). Using the extensive correspondence between the two men, as well as Needham's files on "inner alchemy" deposited at the Needham Research Institute, the paper begins with a partial reconstruction of a 1977 symposium, chaired by Needham, to promote Chang's new book, The Tao of Love and Sex: The Ancient Chinese Way to Ecstasy. Needham and Chang's visions of Chinese sex are then read against excerpts from Science and Civilisation in China, specifically Volume V: Chemistry and Chemical Technology, Part 5: Spagyrical Discovery and Invention: Physiological Alchemy (1983). Three inter-related aspects are explored. First, reading Science and Civilisation in China against materials in the Needham archives offers crucial hints to Needham's historiography and historical practice. Second, the way that Daoist regimens came to be actively reconstructed and repackaged as practices concerned with the enhancement of sexual pleasure and intensity. Third, the investigation of the networks and circulations of assumptions, visions, fantasies about "China". PMID:22652507

  11. Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment.

    PubMed

    Onofre, Isabel; Mendonça, Nuno; Lopes, Sara; Nobre, Rui; de Melo, Joana Barbosa; Carreira, Isabel Marques; Januário, Cristina; Gonçalves, António Freire; de Almeida, Luis Pereira

    2016-01-01

    Machado Joseph Disease (MJD) is the most frequent autosomal dominantly inherited cerebellar ataxia caused by the over-repetition of a CAG trinucleotide in the ATXN3 gene. This expansion translates into a polyglutamine tract within the ataxin-3 protein that confers a toxic gain-of-function to the mutant protein ataxin-3, contributing to protein misfolding and intracellular accumulation of aggregates and neuronal degeneration. Autophagy impairment has been shown to be one of the mechanisms that contribute for the MJD phenotype. Here we investigated whether this phenotype was present in patient-derived fibroblasts, a common somatic cell type used in the derivation of induced pluripotent stem cells and subsequent differentiation into neurons, for in vitro disease modeling. We generated and studied adult dermal fibroblasts from 5 MJD patients and 4 healthy individuals and we found that early passage MJD fibroblasts exhibited autophagy impairment with an underlying mechanism of decreased autophagosome production. The overexpression of beclin-1 on MJD fibroblasts reverted partially autophagy impairment by increasing the autophagic flux but failed to increase the levels of autophagosome production. Overall, our results provide a well-characterized MJD fibroblast resource for neurodegenerative disease research and contribute for the understanding of mutant ataxin-3 biology and its molecular consequences. PMID:27328712

  12. Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment

    PubMed Central

    Onofre, Isabel; Mendonça, Nuno; Lopes, Sara; Nobre, Rui; de Melo, Joana Barbosa; Carreira, Isabel Marques; Januário, Cristina; Gonçalves, António Freire; de Almeida, Luis Pereira

    2016-01-01

    Machado Joseph Disease (MJD) is the most frequent autosomal dominantly inherited cerebellar ataxia caused by the over-repetition of a CAG trinucleotide in the ATXN3 gene. This expansion translates into a polyglutamine tract within the ataxin-3 protein that confers a toxic gain-of-function to the mutant protein ataxin-3, contributing to protein misfolding and intracellular accumulation of aggregates and neuronal degeneration. Autophagy impairment has been shown to be one of the mechanisms that contribute for the MJD phenotype. Here we investigated whether this phenotype was present in patient-derived fibroblasts, a common somatic cell type used in the derivation of induced pluripotent stem cells and subsequent differentiation into neurons, for in vitro disease modeling. We generated and studied adult dermal fibroblasts from 5 MJD patients and 4 healthy individuals and we found that early passage MJD fibroblasts exhibited autophagy impairment with an underlying mechanism of decreased autophagosome production. The overexpression of beclin-1 on MJD fibroblasts reverted partially autophagy impairment by increasing the autophagic flux but failed to increase the levels of autophagosome production. Overall, our results provide a well-characterized MJD fibroblast resource for neurodegenerative disease research and contribute for the understanding of mutant ataxin-3 biology and its molecular consequences. PMID:27328712

  13. Franz Joseph Gall and music: the faculty and the bump.

    PubMed

    Eling, Paul; Finger, Stanley; Whitaker, Harry

    2015-01-01

    The traditional story maintains that Franz Joseph Gall's (1758-1828) scientific program began with his observations of schoolmates with bulging eyes and good verbal memories. But his search to understand human nature, in particular individual differences in capacities, passions, and tendencies, can also be traced to other important observations, one being of a young girl with an exceptional talent for music. Rejecting contemporary notions of cognition, Gall concluded that behavior results from the interaction of a limited set of basic faculties, each with its own processes for perception and memory, each with its own territory in both cerebral or cerebellar cortices. Gall identified 27 faculties, one being the sense of tone relations or music. The description of the latter is identical in both his Anatomie et Physiologie and Sur les Fonctions du Cerveau et sur Celles de Chacune de ses Parties, where he provided positive and negative evidences and discussed findings from humans and lower animals, for the faculty. The localization of the cortical faculty for talented musicians, he explained, is demonstrated by a "bump" on each side of the skull just above the angle of the eye; hence, the lower forehead of musicians is broader or squarer than in other individuals. Additionally, differences between singing and nonsinging birds also correlate with cranial features. Gall even brought age, racial, and national differences into the picture. What he wrote about music reveals much about his science and creative thinking. PMID:25684283

  14. Moths on the Flatbed Scanner: The Art of Joseph Scheer.

    PubMed

    Buchmann, Stephen L

    2011-01-01

    During the past decade a few artists and even fewer entomologists discovered flatbed scanning technology, using extreme resolution graphical arts scanners for acquiring high magnification digital images of plants, animals and inanimate objects. They are not just for trip receipts anymore. The special attributes of certain scanners, to image thick objects is discussed along with the technical features of the scanners including magnification, color depth and shadow detail. The work of pioneering scanner artist, Joseph Scheer from New York's Alfred University is highlighted. Representative flatbed-scanned images of moths are illustrated along with techniques to produce them. Collecting and preparing moths, and other objects, for scanning are described. Highlights of the Fulbright sabbatical year of professor Scheer in Arizona and Sonora, Mexico are presented, along with comments on moths in science, folklore, art and pop culture. The use of flatbed scanners is offered as a relatively new method for visualizing small objects while acquiring large files for creating archival inkjet prints for display and sale. PMID:26467835

  15. Electrical Enlightenment: Joseph Priestley's Historical and Experimental Studies of Electricity

    NASA Astrophysics Data System (ADS)

    Boantza, Victor

    Joseph Priestley (1733-1804) was one of the most controversial public figures of the eighteenth century. A true Enlightenment polymath, he wrote more than two hundred books, pamphlets, sermons, and essays on subjects ranging from science to politics and from metaphysics to theology. He was a religious dissenter, political radical, vocal supporter of the French Revolution, and lifelong defender of the losing side in the Chemical Revolution. Priestley is best known for having ``discovered'' oxygen in the 1770s and for his lasting contributions to pneumatic chemistry. Yet his first scientific fascination, while teaching at Warrington Academy, was electricity--one of the greatest scientific fads of the Enlightenment. Priestley's work on electricity, both historical and experimental, culminated in his History and Present State of Electricity (1767), which became a standard textbook on the subject for nearly a century, and went through numerous editions and translations. Situating Priestley's electrical investigations against the background of eighteenth-century ideals of scientific theory and practice, especially concerning physics, experimental philosophy, and natural history, illuminates the relations between science, society, and epistemology in the Enlightenment.

  16. The birth of chronobiology: Julien Joseph Virey 1814.

    PubMed

    Reinberg, A E; Lewy, H; Smolensky, M

    2001-03-01

    Julien-Joseph Virey (1775-1846) held the position of pharmacist-in-chief at the Val-de-Grâce, a military hospital. He was an innovative pharmacist, naturalist, anthropologist, and philosopher and a prolific author. His writings encompassed a wide range of topics, although many of his ideas were sometimes harshly questioned. Interest in Virey's work today stems from renewed appreciation of his doctoral thesis in medicine, which was completed in 1814 in Paris and was the first devoted to biological rhythms. Virey envisioned biological rhythms to be innate in origin and controlled by living clocks entrained by periodic environmental changes, such as the day-night alternation in light and darkness. He also reported that the effects of drugs vary according to their administration time. But, above all, he collected and published quantified time series that demonstrated human circadian and annual mortality rhythms. Statistical analysis of Virey's data using modern time series methods confirms his deduction that human mortality exhibits rhythmicity. Comparison of his findings with those derived from analyses of more recent human mortality time series shows the characteristics of these rhythms have changed little since 1807 despite differences in environmental conditions. Virey deserves credit for establishing the field of chronobiology based on his insights and writings. PMID:11379660

  17. Sewage-sludge-derived carbonaceous materials for catalytic wet hydrogen peroxide oxidation of m-cresol in batch and continuous reactors.

    PubMed

    Yu, Yang; Wei, Huangzhao; Yu, Li; Wang, Wei; Zhao, Ying; Gu, Bin; Sun, Chenglin

    2016-01-01

    In this study, four sewage-sludge-derived carbonaceous materials (SWs) were evaluated for their catalytic wet hydrogen peroxide oxidation (CWPO) performance of m-cresol in batch reactor and continuous reactor, respectively. The SWs were produced by carbonization (SW); carbonization with the addition of CaO (CaO-SW); HNO3 pretreatment (HNO3-SW) and steam activation (Activated-SW). The properties of SW catalysts were assessed by thermogravimetric analysis, Brunauer-Emmett-Teller, Fourier Transform Infrared Spectroscopy, X-ray Fluorescence, Scanning electron microscopy, energy dispersive X-ray analysis and zeta potential. The results showed that SW treated by HNO3 (HNO3-SW) had a high conversion of m-cresol in batch reactor and continuous reactor, respectively. Under the conditions of batch reaction (Cm-cresol = 100 mg L(-1), CH2O2 = 15.7 mmol L(-1), initial pH=7.0, 0.5 g L(-1) catalyst, 80°C, 180 min adsorption and 210 min oxidation), the conversion of m-cresol reached 100% and total organic carbon removal was 67.1%. It had a high catalytic activity and stability on the treatment of m-cresol in CWPO for more than 1100 h. Furthermore, a possible reaction mechanism for the oxidation of m-cresol to 2-methyl-p-benzoquinone by CWPO was proposed. PMID:26109374

  18. Mainstream partial nitritation and anammox in a 200,000 m3/day activated sludge process in Singapore: scale-down by using laboratory fed-batch reactor.

    PubMed

    Yeshi, Cao; Hong, Kwok Bee; van Loosdrecht, Mark C M; Daigger, Glen T; Yi, Png Hui; Wah, Yuen Long; Chye, Chua Seng; Ghani, Yahya Abd

    2016-01-01

    A laboratory fed-batch reactor has been used to study under controlled conditions the performance of partial nitritation/anammox for the 200,000 m(3)/day step-feed activated sludge process at the Changi Water Reclamation Plant, Singapore. The similarity of the concentrations of NH(4), NO(2), NO(3), PO(4), suspended chemical oxygen demand (sCOD), pH, and alkalinity (ALK) between the on-site process and laboratory reactor illustrates that the laboratory fed-batch reactor can be used to simulate the site performance. The performance of the reactor fed by primary effluent illustrated the existence of anammox and heterotrophic denitrification and apparent excessive biological phosphorus removal as observed from the site. The performance of the reactor fed by final effluent proved the presence of anammox process on site. Both the laboratory reactor and on-site process showed that higher influent 5-day biochemical oxygen demand/total nitrogen (BOD(5)/TN) (COD/TN) ratio increases the nitrogen removal efficiency of the process. PMID:27386982

  19. Notes on Joseph Fraunhofer's honorary Ph.D. degree from Erlangen, 1822 (German Title: Bemerkungen zur Ehrenpromotion Joseph Fraunhofers 1822 in Erlangen )

    NASA Astrophysics Data System (ADS)

    Ventzke, Karl

    In 1822, Joseph Fraunhofer received a honorary Ph.D. degree from Erlangen University. Presumably, this distinction was based on suggestions by Johann Wilhelm Pfaff. Since 1822, Pfaff gave lectures with the inclusion of instruments, which he obtained directly from Fraunhofer, and presumably also included problems of spectral investigation. This contribution analyzes informations which were collected in this regard.

  20. Oral Histories in Meteoritics and Planetary Science - XVII: Joseph Goldstein

    NASA Astrophysics Data System (ADS)

    Sears, Derek W. G.

    2012-05-01

    In this interview, Joseph Goldstein (Fig. 1) recounts how he became interested in meteorites during his graduate studies working with Robert Ogilvie at MIT. By matching the Ni profiles observed across taenite fields in the Widmanstätten structure of iron meteorites with profiles he computed numerically he was able to determine cooling rates as the meteorites cooled through 650-400 °C. Upon graduating, he worked with a team of meteorite researchers led by Lou Walter at Goddard Space Flight Center where for 4 years he attempted to understand metallographic structures by reproducing them in the laboratory. Preferring an academic environment, Joe accepted a faculty position in the rapidly expanding metallurgy department at Lehigh University where he was responsible for their new electron microprobe. He soon became involved in studying the metal from lunar soils and identifying the metallic component from its characteristic iron and nickel compositions. Over the next two decades he refined these studies of Ni diffusion in iron meteorites, particularly the effect of phosphorus in the process, which resulted in superior Fe-Ni-P phase diagrams and improved cooling rates for the iron meteorites. After a period as vice president for research at Lehigh, in 1993 he moved to the University of Massachusetts to serve as dean of engineering, but during these administrative appointments Joe produced a steady stream of scientific results. Joe has served as Councilor, Treasurer, Vice President, and President of the Meteoritical Society. He received the Leonard Medal in 2005, the Sorby Award in 1999, and the Dumcumb Award for in 2008.

  1. A linkage study of Machado-Joseph disease - refining the localisation of the gene

    SciTech Connect

    Gaspar, C.; Twist, E.C.; Maciel, P.

    1994-09-01

    Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative ataxia originally described in families of Azorean-Portuguese descent. It is believed to be due to the mutation of a single, as yet unidentified gene which has been mapped using genetic linkage analysis to a 29 cM region of chromosome 14q24.3-q32 in five Japanese families. The aim of this study was to refine the localization of the MJD gene by typing additional markers in this 29 cM interval. Blood was collected and DNA isolated from 355 individuals including 171 affected persons who are part of 6 Portuguese/Azorean, 6 American/Azorean and 1 Brazilian kindred. Pedigrees were typed with highly polymorphic di- and tetranucleotide repeat markers spanning the 29 cM region of chromosome 14q containing the gene. Markers tested include D14S74, D14S55, D14S124, D14S48, D14S128, D14S68, D14S256, AFM343vfl, D14S45, and D14S51. Linkage between the MJD locus and the markers was analyzed using the computer programs LIPED and LINKAGE. In addition, haplotype analysis of all 13 families was carried out. To date, the maximum cumulative two point lod score of 14.34 at a recombination fraction of 0.05 has been obtained with the marker AFM343vfl. From haplotype analysis, D14S68 and AFM343vfl have been identified as flanking markers. Thus the region of chromosome 14q containing the MJD gene has been narrowed from an interval of 29 cm to approximately 11 cM.

  2. A comparison of rat SPECT images obtained using 99mTc derived from 99Mo produced by an electron accelerator with that from a reactor

    NASA Astrophysics Data System (ADS)

    Galea, R.; Wells, R. G.; Ross, C. K.; Lockwood, J.; Moore, K.; Harvey, J. T.; Isensee, G. H.

    2013-05-01

    Recent shortages of molybdenum-99 (99Mo) have led to an examination of alternate production methods that could contribute to a more robust supply. An electron accelerator and the photoneutron reaction were used to produce 99Mo from which technetium-99m (99mTc) is extracted. SPECT images of rat anatomy obtained using the accelerator-produced 99mTc with those obtained using 99mTc from a commercial generator were compared. Disks of 100Mo were irradiated with x-rays produced by a 35 MeV electron beam to generate about 1110 MBq (30 mCi) of 99Mo per disk. After target dissolution, a NorthStar ARSII unit was used to separate the 99mTc, which was subsequently used to tag pharmaceuticals suitable for cardiac and bone imaging. SPECT images were acquired for three rats and compared to images for the same three rats obtained using 99mTc from a standard reactor 99Mo generator. The efficiency of 99Mo-99mTc separation was typically greater than 90%. This study demonstrated the delivery of 99mTc from the end of beam to the end user of approximately 30 h. Images obtained using the heart and bone scanning agents using reactor and linac-produced 99mTc were comparable. High-power electron accelerators are an attractive option for producing 99Mo on a national scale.

  3. Mini-cavity plasma core reactors for dual-mode space nuclear power/propulsion systems. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Chow, S.

    1976-01-01

    A mini-cavity plasma core reactor is investigated for potential use in a dual-mode space power and propulsion system. In the propulsive mode, hydrogen propellant is injected radially inward through the reactor solid regions and into the cavity. The propellant is heated by both solid driver fuel elements surrounding the cavity and uranium plasma before it is exhausted out the nozzle. The propellant only removes a fraction of the driver power, the remainder is transferred by a coolant fluid to a power conversion system, which incorporates a radiator for heat rejection. Neutronic feasibility of dual mode operation and smaller reactor sizes than those previously investigated are shown to be possible. A heat transfer analysis of one such reactor shows that the dual-mode concept is applicable when power generation mode thermal power levels are within the same order of magnitude as direct thrust mode thermal power levels.

  4. Cytokines in Machado Joseph Disease/Spinocerebellar Ataxia 3.

    PubMed

    da Silva Carvalho, Gerson; Saute, Jonas Alex Morales; Haas, Clarissa Branco; Torrez, Vitor Rocco; Brochier, Andressa Wigner; Souza, Gabriele Nunes; Furtado, Gabriel Vasata; Gheno, Tailise; Russo, Aline; Monte, Thais Lampert; Schumacher-Schuh, Artur; D'Avila, Rui; Donis, Karina Carvalho; Castilhos, Raphael Machado; Souza, Diogo Onofre; Saraiva-Pereira, Maria Luiza; Torman, Vanessa Leotti; Camey, Suzi; Portela, Luis Valmor; Jardim, Laura Bannach

    2016-08-01

    The aim of the present study is to describe the serum concentrations of a broad spectrum of cytokines in symptomatic and asymptomatic carriers of Machado Joseph disease (SCA3/MJD) CAG expansions. Molecularly confirmed carriers and controls were studied. Age at onset, disease duration, and clinical scales Scale for the Assessment and Rating of Ataxia (SARA), Neurological Examination Score for Spinocerebellar Ataxias (NESSCA), SCA Functional Index (SCAFI), and Composite Cerebellar Functional Score (CCFS) were obtained from the symptomatic carriers. Serum was obtained from all individuals and a cytokine panel "consisted of" eotaxin, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon (IFN)-α, IFN-γ, interleukin (IL)-1β, IL-1RA, IL-2, IL-2R, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-15, IL-17, interferon gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, monokine induced by gamma interferon (MIG), macrophage inflammatory protein (MIP)-a, MIP-b, regulated on activation, normal T cell expressed and secreted (RANTES) and tumor necrosis factor (TNF)-α was analyzed. In a subgroup of symptomatic carriers, the cytokine panel was repeated after 360 days. Cytokine distribution among groups was studied by discriminant analysis; changes in serum levels after 360 days were studied by generalized estimation equation. Sixty-six symptomatic carriers, 13 asymptomatic carriers, and 43 controls were studied. No differences in cytokine patterns were found between controls and carriers of the CAG expansions or between controls and symptomatic carriers only. In contrast, eotaxin concentrations were significantly higher in asymptomatic than in symptomatic carriers or in controls (p = 0.001, ANCOVA). Eotaxin did not correlate with age, disease duration, CAG expansion, NESSCA score, and SARA score. Among symptomatic carriers, eotaxin dropped after 360 days (p = 0.039, GEE). SCA3/MJD patients presented a benign pattern of

  5. Machado-Joseph Disease: from first descriptions to new perspectives

    PubMed Central

    2011-01-01

    Machado-Joseph Disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), represents the most common form of SCA worldwide. MJD is an autosomal dominant neurodegenerative disorder of late onset, involving predominantly the cerebellar, pyramidal, extrapyramidal, motor neuron and oculomotor systems; although sharing features with other SCAs, the identification of minor, but more specific signs, facilitates its differential diagnosis. MJD presents strong phenotypic heterogeneity, which has justified the classification of patients into three main clinical types. Main pathological lesions are observed in the spinocerebellar system, as well as in the cerebellar dentate nucleus. MJD's causative mutation consists in an expansion of an unstable CAG tract in exon 10 of the ATXN3 gene, located at 14q32.1. Haplotype-based studies have suggested that two main founder mutations may explain the present global distribution of the disease; the ancestral haplotype is of Asian origin, and has an estimated age of around 5,800 years, while the second mutational event has occurred about 1,400 years ago. The ATXN3 gene encodes for ataxin-3, which is ubiquitously expressed in neuronal and non-neuronal tissues, and, among other functions, is thought to participate in cellular protein quality control pathways. Mutated ATXN3 alleles consensually present about 61 to 87 CAG repeats, resulting in an expanded polyglutamine tract in ataxin-3. This altered protein gains a neurotoxic function, through yet unclear mechanisms. Clinical variability of MJD is only partially explained by the size of the CAG tract, which leaves a residual variance that should be explained by still unknown additional factors. Several genetic tests are available for MJD, and Genetic Counseling Programs have been created to better assist the affected families, namely on what concerns the possibility of pre-symptomatic testing. The main goal of this review was to bring together updated knowledge on MJD, covering

  6. The glacial geology of southern St. Joseph County, Michigan

    NASA Astrophysics Data System (ADS)

    Nicks, Linda

    The objective of the dissertation was to map the glacial geology in southern St. Joseph County, Michigan. The surficial geology was divided into three distinct land systems which are moraine, outwash and fan deposits. The Sturgis Moraine is the most prominent feature transecting the study area from east to west. The topography is further dissected by southwest-trending channels interpreted as tunnel channels. Thick accumulations of sand and gravel in the study area indicate that glacial meltwater deposition played a dominant role in shaping the landscape. Based on the relative size of the channels and outwash deposits, the largest contribution from meltwater deposition was from the Saginaw Lobe and the least from the Huron-Erie Lobe. This study also demonstrated that geophysical techniques such as gamma ray logging of domestic water wells, ground penetrating radar and high resolution seismic were useful tools to identify sand, gravel and clay in the subsurface and the thickness of these units. Seven subsurface, gamma ray log markers could be traced throughout the study area. The gamma ray log markers were calibrated to four continuous cores from Sturgis. The lowest marker, the Sturgis till, lies above a buried soil of possible Sangamon age and is interpreted as a late Wisconsin till. It is present in all wells that are drilled to an adequate depth. Directly overlying the Sturgis till (between markers F--G), is a thin diamicton of similar color but different clay mineralogy (between markers E--F). This thin diamicton is variable in thickness and sometimes there is a facies change from diamicton to coarser grained material at the same stratigraphic level. This sequence is overlain by a sequence of sand and gravel (between markers A and E). This coarse grained sequence is sometimes punctuated by a sequence (or sequences) of higher gamma ray counts interpreted as finer grained units and these individual markers can be traced throughout the study area (markers A

  7. BOOK REVIEW: Joseph Henry: The Rise of an American Scientist

    NASA Astrophysics Data System (ADS)

    Crawford, Elspeth

    1998-09-01

    Albert Moyer has clearly done his research into the events of Joseph Henry's life. The personal, professional, sociological and scientific aspects have been meticulously detailed throughout and the ordering, as in the chapter headings, is chronological, so that there is some element of each of these aspects in each chapter. This is unfortunately both the strength and the weakness of the biography, as the detail seemed to me to be the most remarkable characteristic of the writing. But, the bigger stories, or the themes, which might have been possible, seemed to get lost. Hence, I found this a book for those who are seriously interested in Joseph Henry; but for those whose interest might be more general, say having an interest in nineteenth century growth of scientific institutions, or wanting to understand the conceptual development of electromagnetism, there seemed to be too much which came from the Henry point of view, rather than locating Henry within his time and context. This is a remark about style, rather than omission of content, as the myriad of details in each paragraph certainly inform the reader about the context. For instance, some sociology of the USA in the nineteenth century could be inferred, say showing how a young man from a modest background might make his way into a professional life, but the information is so particularly a description of Henry's experience that one has to rely on prior knowledge or make assumptions in order to create a sociological perspective. That is, I now know, what happened to Henry, but I do not know if his case was in any sense typical or atypical. Similarly there is information about education in general at that time, and scientific education, research and its publication, as it applied to Henry. The relationships between science in the USA and in Europe have a place, and there is quite a bit of information about the institutions in which Henry worked, particularly Albany Academy, Princeton and the Smithsonian. Henry

  8. BOOK REVIEW: Joseph Henry: The Rise of an American Scientist

    NASA Astrophysics Data System (ADS)

    Crawford, Elspeth

    1998-09-01

    Albert Moyer has clearly done his research into the events of Joseph Henry's life. The personal, professional, sociological and scientific aspects have been meticulously detailed throughout and the ordering, as in the chapter headings, is chronological, so that there is some element of each of these aspects in each chapter. This is unfortunately both the strength and the weakness of the biography, as the detail seemed to me to be the most remarkable characteristic of the writing. But, the bigger stories, or the themes, which might have been possible, seemed to get lost. Hence, I found this a book for those who are seriously interested in Joseph Henry; but for those whose interest might be more general, say having an interest in nineteenth century growth of scientific institutions, or wanting to understand the conceptual development of electromagnetism, there seemed to be too much which came from the Henry point of view, rather than locating Henry within his time and context. This is a remark about style, rather than omission of content, as the myriad of details in each paragraph certainly inform the reader about the context. For instance, some sociology of the USA in the nineteenth century could be inferred, say showing how a young man from a modest background might make his way into a professional life, but the information is so particularly a description of Henry's experience that one has to rely on prior knowledge or make assumptions in order to create a sociological perspective. That is, I now know, what happened to Henry, but I do not know if his case was in any sense typical or atypical. Similarly there is information about education in general at that time, and scientific education, research and its publication, as it applied to Henry. The relationships between science in the USA and in Europe have a place, and there is quite a bit of information about the institutions in which Henry worked, particularly Albany Academy, Princeton and the Smithsonian. Henry

  9. Heat production in depth up to 2500m via in situ combustion of methane using a counter-current heat-exchange reactor

    NASA Astrophysics Data System (ADS)

    Schicks, Judith Maria; Spangenberg, Erik; Giese, Ronny; Heeschen, Katja; Priegnitz, Mike; Luzi-Helbing, Manja; Thaler, Jan; Abendroth, Sven; Klump, Jens

    2014-05-01

    In situ combustion is a well-known method used for exploitation of unconventional oil deposits such as heavy oil/bitumen reservoirs where the required heat is produced directly within the oil reservoir by combustion of a small percentage of the oil. A new application of in situ combustion for the production of methane from hydrate-bearing sediments was tested at pilot plant scale within the first phase of the German national gas hydrate project SUGAR. The applied method of in situ combustion was a flameless, catalytic oxidation of CH4 in a counter-current heat-exchange reactor with no direct contact between the catalytic reaction zone and the reservoir. The catalyst permitted a flameless combustion of CH4 with air to CO2 and H2O below the auto-ignition temperature of CH4 in air (868 K) and outside the flammability limits. This led to a double secured application of the reactor. The relatively low reaction temperature allowed the use of cost-effective standard materials for the reactor and prevented NOx formation. Preliminary results were promising and showed that only 15% of the produced CH4 was needed to be catalytically burned to provide enough heat to dissociate the hydrates in the environment and release CH4. The location of the heat source right within the hydrate-bearing sediment is a major advantage for the gas production from natural gas hydrates as the heat is generated where it is needed without loss of energy due to transportation. As part of the second period of the SUGAR project the reactor prototype of the first project phase was developed further to a borehole tool. The dimensions of this counter-current heat-exchange reactor are about 540 cm in length and 9 cm in diameter. It is designed for applications up to depths of 2500 m. A functionality test and a pressure test of the reactor were successfully carried out in October 2013 at the continental deep drilling site (KTB) in Windischeschenbach, Germany, in 600 m depth and 2000 m depth, respectively

  10. 78 FR 7813 - Sanjay Trivedi, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... authority''); Beverley P. Edwards, M.D., 75 FR 49,991 (DEA 2010); Joseph Baumstarck, M.D., 74 FR 17,525 (DEA... Florida. Consequently, his DEA registration must be revoked. See Joseph Baumstarck, M.D., 74 FR 17,525, 17... Coast Specialty Pharmacy, 76 FR 66,965 (DEA 2011); Roy Chi Lung, M.D., 74 FR 20,346 (DEA 2009);...

  11. Transient analyses for the Uzbekistan VVR-SM reactor with IRT-3M HEU fuel and IRT-4M LEU fuel : ANL independent verification results.

    SciTech Connect

    Garner, P. L.; Hanan, N. A.; Nuclear Engineering Division

    2007-09-24

    Calculations have been performed for postulated transients in the VVR-SM Reactor at the Institute of Nuclear Physics (INP) of the Academy of Sciences in the Republic of Uzbekistan. (The reactor designation in Cyrillic is BBP-CM; transliterating characters to English gives VVRSM but translating words gives WWR-SM.) These calculations have been performed at the request of staff of the INP who are performing similar calculations. The transients considered were established during working meetings between Argonne National Laboratory (ANL) and INP staff during summer 2006 [Ref. 1], subsequent email correspondence, and subsequent staff visits. Calculations were performed for the current high-enriched uranium (HEU) core, the proposed low-enriched uranium (LEU) core, and one mixed HEU-LEU core during the transition. These calculations have been performed independently from those being performed by INP and serve as one step in the verification process.

  12. [The vitalism of Paul-Joseph Barthez (1734-1806)].

    PubMed

    Han, Hee Jin

    2010-06-30

    In The Logic of Life (1970), Francois Jacob (1920- ), Nobel Prize laureate in Physiology or Medicine (1965), proclaimed the end of vitalism based on the concept of life. More than two decades before this capital sentence condemning vitalism was pronounced, Georges Canguilhem (1904-1995), a French philosopher of medicine, already acknowledged that eighteenth-century vitalism was scientifically retrograde and politically reactionary or counter-revolutionary insofar as it was rooted in the animism of Georg Ernst Stahl (1660-1734). The negative preconception of the term 'vitalism' came to be established as an orthodox view, since Claude Bernard (1813-1878) unfairly criticized contemporary vitalism in order to propagate his idea of experimental medicine. An eminent evolutionary biologist like Ernst Mayr (1904-2005) still defended similar views in This is Biology (1997), arguing that if vitalists were decisive and convincing in their rejection of the Cartesian model (negative heuristics), however they were equally indecisive and unconvincing in their own explanatory endeavors (positive heuristics). Historically speaking, vitalists came to the forefront for their outstanding criticism of Cartesian mechanism and physicochemical reductionism, while their innovative concepts and theories were underestimated and received much less attention. Is it true that vitalism was merely a pseudo-science, representing a kind of romanticism or mysticism in biomedical science? Did vitalists lack any positive heuristics in their biomedical research? Above all, what was actually the so.called 'vitalism'? This paper aims to reveal the positive heuristics of vitalism defined by Paul.Joseph Barthez (1734-1806) who was the founder of the vitalist school of Montpellier. To this end, his work and idea are introduced with regard to the vying doctrines in physiology and medicine. At the moment when he taught at the medical school of Montpellier, his colleagues advocated the mechanism of Rene

  13. 76 FR 11291 - University of New Mexico AGN-201M Reactor Notice of Issuance of Renewed Facility Operating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ..., Division of Policy and Rulemaking, Office of Nuclear Reactor Regulation. BILLING CODE 7590-01-P ... FR 67927). The NRC received no request for a hearing or petition for leave to intervene following the... 14, 2010 (75 FR 27372), and concluded that renewal of the license will not have a significant...

  14. Constructing Secret Rooms: Assemblages, Creative Writing, Self-discovery, and the Art of Joseph Cornell.

    ERIC Educational Resources Information Center

    Platt, Thomas Julian

    1998-01-01

    Profiles a course that challenges college seniors to gain new perspectives, skills, experiences, and insights into their own creative and imaginative processes. The course uses the work of Joseph Cornell who constructed enigmatic, box-like assemblages from found objects. Students construct their own boxes and consider future applications of this…

  15. Conceiving of Concept Maps to Foster Meaningful Learning: An Interview with Joseph D. Novak

    ERIC Educational Resources Information Center

    Cardellini, Liberato

    2004-01-01

    Joseph Novak discusses the concept of mapping to capture and archive expert knowledge. He worked in various corporations where he used the concept of mapping for research and development efforts and to create and transfer knowledge and information in corporate environments.

  16. A Short Biography of Joseph Fourier and Historical Development of Fourier Series and Fourier Transforms

    ERIC Educational Resources Information Center

    Debnath, Lokenath

    2012-01-01

    This article deals with a brief biographical sketch of Joseph Fourier, his first celebrated work on analytical theory of heat, his first great discovery of Fourier series and Fourier transforms. Included is a historical development of Fourier series and Fourier transforms with their properties, importance and applications. Special emphasis is made…

  17. What's in a Coauthor?: (Re)Locating Joseph Denney in Composition History

    ERIC Educational Resources Information Center

    Davis, Ivan

    2012-01-01

    This article reassesses the Fred Newton Scott and Joseph Villiers Denney collaborative textbook authorship by emphasizing Denney's generally overlooked contributions to that coauthorship and to the field of composition generally. Through an examination of Denney's scholarly work and his personal correspondence with Scott during the period marking…

  18. Ethnographic Research and Globalization: A Discussion of Joseph Tobin's Model of Video-Cued Multivocal Ethnography

    ERIC Educational Resources Information Center

    Watras, Joseph

    2014-01-01

    Joseph Tobin made an impact on the field of comparative education in 2009 when he used a unique form of ethnography to illuminate the effects of world-wide forces, such as modernization, on schools in specific countries. Earlier, in 1989, he published "Preschool in Three Cultures" with co-authors David Wu and Dana Davidson. The…

  19. Joseph Priestley Is the Focus as Modern Chemistry Celebrates Its Second Century

    ERIC Educational Resources Information Center

    Bernheim, Robert A.; Olofson, Roy A.

    1974-01-01

    This article describes a meeting in 1874, seen to be the origin of the American Chemical Society, which commemorated the 100th anniversary of Joseph Priestley's discovery of oxygen. The remainder of the article is concerned with Priestley's scientific contributions and their implications. (DT)

  20. Joseph Pulitzer II and Advertising Censorship, 1929-1939. Journalism Monographs Number Seventy-seven.

    ERIC Educational Resources Information Center

    Pfaff, Daniel W.

    In an age of little or no consumer protection, the St. Louis "Post-Dispatch," under the guidance of Joseph Pulitzer II, was the first and most successful practitioner of self-imposed censorship of advertising, a practice that continues to this day. Beginning on May 1, 1929, the "Post-Dispatch" announced an aggressive program of advertising…

  1. Assessing conservation effects on water quality in the St. Joseph River Watershed

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Agriculture is a major contributor to non-point source pollution of streams, rivers and lakes. The St. Joseph River is a major drinking water source in northeastern Indiana that has been contaminated by chemicals in runoff. A Source Water Protection Initiative project began in 2002, with the focus ...

  2. Highlighting High Performance Buildings: Adam Joseph Lewis Center for Environmental Studies

    SciTech Connect

    2002-11-01

    Oberlin College's Adam Joseph Lewis Center for Environmental Studies is a high-performance building featuring an expansive photovoltaic system and a closed-loop groundwater heat pump system. Designers incorporated energy-efficient components and materials that are local, non-toxic, and durable.

  3. Joseph McCabe: A Forgotten Early Populariser of Science and Defender of Evolution

    ERIC Educational Resources Information Center

    Cooke, Bill

    2010-01-01

    Joseph McCabe (1867-1955) was one of the most prolific and gifted polymaths of the twentieth century. Long before such a thing was thought respectable, and almost a century before any university established a chair in the public understanding of science, McCabe made a living as a populariser of science and a critic of philosophical and religious…

  4. Factors Influencing Nutrient Losses from Agriculture in the St. Joseph River Watershed, Northeast Indiana

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Nutrient losses from agricultural watersheds in Indiana have been implicated in the hypoxic zone in the Gulf of Mexico as well as massive algal blooms in Lake Erie. We monitored water quality from fields and drainage ditches in the St. Joseph River Watershed, Northeast Indiana. The complex ‘pot-ho...

  5. Joseph Ames's "Typographical Antiquities" and the Antiquarian Tradition

    ERIC Educational Resources Information Center

    Shiner, Elaine

    2013-01-01

    One of the most famous historical documents of English printing is Joseph Ames's "Typographical Antiquities," published in London in 1749. Although Ames referred to his work as a history of printing, the bulk of it is a list of the first printers in England and their works through 1600, with very full bibliographical descriptions…

  6. Joseph Walker, a Black Playwright, Exhorts Counselors and Black People to Deal With Themselves

    ERIC Educational Resources Information Center

    Walker, Joseph

    1976-01-01

    This is an interview with Joseph Walker, black playwright. He attempts to reflect back to the black community their experience in a white controlled world. In this interview, he discusses his views of the black experience, the pressures on man-woman relationships, and the role of black psychiatry. (NG)

  7. Astronauts Joseph Allen rides cherry picker over stowage area/work station

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronaut Joseph P. Allen rides a cherry picker over to a stowage area/work station to wrap up extravehicular activity (EVA) duties above Earth. The cherry picker is a union of the mobile foot restraint and the remote manipulator system (RMS), controlled from inside Discovery's cabin. The Westar VI/PAM-D satellite is pictured secured in Discovery's cargo bay.

  8. Exceptional Scholarship and Democratic Agendas: Interviews with John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni

    ERIC Educational Resources Information Center

    Mullen, Carol A.

    2006-01-01

    This portraiture study of four exceptional scholars in education--John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni--provides insight into their scholarly work and life habits, direction and aspirations, assessment and analysis of major trends in the profession, and advice for aspiring leaders and academics. Telephone interviews with…

  9. Exceptional Scholarship and Democratic Agendas: Interviews with John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni

    ERIC Educational Resources Information Center

    Mullen, Carol A.

    2009-01-01

    This portraiture study of four exceptional scholars in education--John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni--provides insight into their scholarly work and life habits, direction and aspirations, assessment and analysis of major trends in the profession, and advice for aspiring leaders and academics. Telephone interviews with…

  10. The St. Joseph River Watershed CEAP Project: Highlights of Recent Refocusing of Our Efforts

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Monitoring in the St. Joseph River watershed was initiated in 2002. Over the last six years, the focus has been on monitoring surface runoff from fields and discharge from drainage ditches and a natural stream. The watershed lies in one of the areas of the country with the greatest density of subs...

  11. The Joseph Bellamy House: Great Awakening in Puritan New England. Teaching with Historic Places.

    ERIC Educational Resources Information Center

    Pape, Barbara Bradbury

    The small rural town of Bethlehem, Connecticut, contains pristine examples of modest 18th-century houses that surround a charming village green. Opposite the village green, the Reverend Joseph Bellamy's immense white clapboard house rises from a hilltop, an imposing presence that makes the village appear diminutive. The house stands today as a…

  12. 75 FR 63801 - Action Affecting Export Privileges; Joseph Piquet and Related Person Alphatronx, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... individual Joseph Piquet (``Piquet'') on May 28, 2010 (75 FR 32742, June 9, 2010) applicable to Alphatronx... August 12, 2010 (75 FR 50,681 (Aug. 16, 2010)), has continued the Regulations in effect under the... published in the Federal Register on June 9, 2010 at 75 FR 32742, shall be made applicable to...

  13. A Curriculum for Character Education: Joseph Schwab and the Ramah Camps

    ERIC Educational Resources Information Center

    Cohen, Burton; Pereira, Peter; Roby, Thomas; Block, Alan

    2005-01-01

    Joseph Schwab (1909-1988) is known for his scathing critique of curriculum theory and its over reliance on quantitative models derived from social science theories. From the late 1950's through the middle 1960's, Schwab was instrumental to efforts to create a new and more educationally sound curriculum for weekday religious schools in synagogues…

  14. Painting as Rhetorical Performance: Joseph Wright's "An Experiment on a Bird in the Air Pump."

    ERIC Educational Resources Information Center

    Helmers, Marguerite

    2001-01-01

    Explores three broad areas of inquiry: what significance visual images have for rhetorical analysis; how a study of nonverbal material might be conducted; and whether visual explanations depend on the image or the viewer. Argues that viewers understand Joseph Wright's painting "The Air Pump" in terms of its subject, its exhibition space, the…

  15. Joseph Woolley--Pioneer of British Naval Education; 1848-1879

    ERIC Educational Resources Information Center

    Dickinson, H. W.

    2007-01-01

    For almost 25 years Joseph Woolley served the Admiralty as a teacher, inspector of schools and as the first Admiralty Director of Education. Despite the fact that Woolley held this post for a decade, that he was the sole occupant in the nineteenth century and that in this capacity he gave evidence to, or was a member of, every government committee…

  16. 46 CFR 45.183 - Load line requirements for the St. Joseph and Muskegon routes.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 2 2013-10-01 2013-10-01 false Load line requirements for the St. Joseph and Muskegon routes. 45.183 Section 45.183 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES GREAT LAKES LOAD LINES Unmanned River Barges on Lake Michigan Routes § 45.183 Load...

  17. 46 CFR 45.183 - Load line requirements for the St. Joseph and Muskegon routes.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 2 2012-10-01 2012-10-01 false Load line requirements for the St. Joseph and Muskegon routes. 45.183 Section 45.183 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES GREAT LAKES LOAD LINES Unmanned River Barges on Lake Michigan Routes § 45.183 Load...

  18. 46 CFR 45.183 - Load line requirements for the St. Joseph and Muskegon routes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Load line requirements for the St. Joseph and Muskegon routes. 45.183 Section 45.183 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES GREAT LAKES LOAD LINES Unmanned River Barges on Lake Michigan Routes § 45.183 Load...

  19. 46 CFR 45.183 - Load line requirements for the St. Joseph and Muskegon routes.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 2 2011-10-01 2011-10-01 false Load line requirements for the St. Joseph and Muskegon routes. 45.183 Section 45.183 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES GREAT LAKES LOAD LINES Unmanned River Barges on Lake Michigan Routes § 45.183 Load...

  20. 46 CFR 45.183 - Load line requirements for the St. Joseph and Muskegon routes.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 2 2014-10-01 2014-10-01 false Load line requirements for the St. Joseph and Muskegon routes. 45.183 Section 45.183 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES GREAT LAKES LOAD LINES Unmanned River Barges on Lake Michigan Routes § 45.183 Load...

  1. The Oral History of Evaluation: The Professional Development of Joseph Wholey

    ERIC Educational Resources Information Center

    Miller, Robin Lin; Caracelli, Valerie

    2013-01-01

    Joseph S. Wholey is Professor Emeritus in the University of Southern California's (USC) School of Public Policy, Planning, and Development. He received his BA from Catholic University, Phi Beta Kappa and his MA in mathematics and PhD in philosophy from Harvard University. His work focuses on the use of strategic planning, performance measurement,…

  2. Toward a Telic Vision of Human Beings: A Dialogue with Joseph F. Rychlak.

    ERIC Educational Resources Information Center

    Howard, George S.

    1987-01-01

    Presents interview with Joseph F. Rychlak on topics of notions of causality in science, relationship of research to practice in humanistic psychology, research evidence for a telic view of human action, counseling active agents, choice and free will, and philosophy of science and humanisitic theory. (ABL)

  3. From Chemical Analysis to Analyzing Chemical Education: An Interview with Joseph J. Lagowski

    ERIC Educational Resources Information Center

    Cardellini, Liberato

    2010-01-01

    This interview provides glimpses of Joseph J. Lagowski and his life from the time he played with a Gilbert chemistry set, to his tenure at The University of Texas at Austin. His initial interest in chemistry was further nurtured and developed thanks to an excellent high school teacher. In the interview, Lagowski discusses his research in…

  4. Psi Chi/APA Edwin B. Newman Graduate Research Award: Joseph H. Hammer

    ERIC Educational Resources Information Center

    American Psychologist, 2009

    2009-01-01

    Joseph H. Hammer, recipient of the Psi Chi/APA Edwin B. Newman Graduate Research Award, is cited for an outstanding research paper whose findings provide important evidence regarding the promise of a male-sensitive approach to mental health marketing and empirically support the inclusion of theory-driven enhancements in group-targeted mental…

  5. Astronaut Joseph Tanner checks gloves during during launch/entry training

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Astronaut Joseph R. Tanner, mission specialist, checks his gloves during a rehearsal for the launch and entry phases of the scheduled November 1994 flight of STS-66. This rehearsal, held in the crew compartment trainer (CCT) of JSC's Shuttle mockup and integration laboratory, was followed by a training session on emergency egress procedures.

  6. Riotous Images: Representations of Joseph Priestley in British Prints during the French Revolution

    ERIC Educational Resources Information Center

    Clay, Richard

    2008-01-01

    This article focuses on printed images that were published in Britain during the 1790s, depicting the educationist, theologian, chemist, physicist, historian and philosopher Joseph Priestley (1733-1804). It is argued that such etchings and engravings are indicative of, and contributed to, the lifelong political and historical education of late…

  7. General Education Assessment and Fulfilling the Mercy Mission at the University of Saint Joseph

    ERIC Educational Resources Information Center

    Callahan, Kevin J.

    2014-01-01

    This article describes the processes and procedures the University of Saint Joseph used to conduct a systematic assessment of mission-related student-learning outcomes found in the General Education curriculum, and thus assess how well the institution was fulfilling its Mercy mission. The assessment showed student learning strengths and gaps and…

  8. Recent theoretical chemical dynamics at Rochester in the paths of Joseph O. Hirschfelder

    NASA Technical Reports Server (NTRS)

    George, T. F.; Lam, K.-S.; Bhattacharyya, D. K.; Hutchinson, M.; Zimmerman, I. H.; Devries, P. L.; Yuan, J.-M.

    1982-01-01

    A review of recent theoretical studies of gas-phase molecular rate processes, including various effects of laser radiation, is presented in the context of the extensive and influential work of Joseph O. Hirschfelder during the past half-century. The topics addressed are energy transfer, chemical reactions, unimolecular dissociation, transition states, and bound-continuum interactions.

  9. Speaking Frankly on the Sexual Behavior of Children--Joseph D. Noshpitz.

    ERIC Educational Resources Information Center

    Long, Nichloas J., Ed.

    1998-01-01

    With the passing of Joseph D. Noshpitz, the field of troubled youth lost a distinguished leader. A founding member of the American Academy of Child and Adolescent Psychiatry, Noshpitz leaves a legacy of pivotal publications. Describes Noshpitz's contributions and shares one of his classic and once-censored articles on sexuality in children.…

  10. The Plight of the American Writer and Joseph Brodsky in Exile.

    ERIC Educational Resources Information Center

    Updike, John; Jacoby, Susan

    1994-01-01

    Two articles originally published in the 1970s are reprinted. The first argues that the American writer no longer knows what is expected of him and has difficulty engaging in conversation with the reader. The second examines the work and teaching of Joseph Brodsky, a Russian poet, while in the United States. (MSE)

  11. [Carcinoma of Unknown Primary Associated with a Sister Mary Joseph's Nodule--A Case Report].

    PubMed

    Yabe, Nobushige; Murai, Shinji; Yokose, Takahiro; Oto, Ippei; Yoshikawa, Takahisa; Kitasato, Kenjiro; Shimizu, Hirotomo; Kojima, Kenji; Hasegawa, Hirotoshi; Kitagawa, Yuko

    2015-11-01

    A 72-year old woman visited our hospital complaining of an umbilical mass and a foul smell from the umbilical region. During the evaluation, a massive immobile tumor was palpated in the center of the lower abdomen in addition to an umbilical mass with necrosis. Computed tomography (CT) revealed a massive ovarian tumor accompanied by an umbilical tumor and cyst with peritoneal dissemination, metastases in the liver and spleen and a urachal tumor. There were no symptoms or imaging findings of gastrointestinal obstruction. While searching for the primary focus, it was determined that the ovarian tumor was not of ovarian origin. Under these circumstances, colonoscopy was the only remaining diagnostic modality. However, evaluation of the large intestine was impossible due to compression by the tumor, and diverticulosis of the sigmoid colon did not allow smooth insertion of the colonoscope. Therefore, an excisional biopsy of the umbilical tumor was performed. The most likely diagnoses based on the histopathological findings were colorectal cancer and urachal cancer. Therefore , mFOLFOX6 was selected for chemotherapy because it has been reported to be effective against both urachal and colorectal cancer. At the time of writing, good tumor control had been achieved in the lesions evaluated. Cases of Sister Mary Joseph's nodule have sporadically been reported. The most common primary foci for peritoneal metastases are the stomach, pancreas and ovary. However, in the present case, these sites were ruled out and the primary focus remained unidentified, making it difficult to select appropriate treatment. We present this case with a discussion of the literature. PMID:26805190

  12. Hydrologic and water-quality characteristics of a Wetland receiving wastewater effluent in St. Joseph, Minnesota

    USGS Publications Warehouse

    Brown, Rob G.; Stark, James R.

    1989-01-01

    Hydrologic and water-quality characteristics were determined for a wetland being used for tertiary treatment of wastewater in St. Joseph, Minnesota. The wetland consists of spruce-tamarack fen and a cattail marsh, with the wastewater being discharged into the fen, and the fen draining into the marsh. The wetland is underlain by flat-lying glacial outwash that ranges from 0 to greater than 20 m in thickness. Horizontal ground-water movement in the outwash aquifer is toward the wetland from the south, east, and west. There is a strong upward vertical hydraulic gradient (about 0.1) in the ground-water flow system beneath and around the wetland. Regionally, the glacial-outwash aquifer is unconfined, but it is confined or partly confined locally by peat deposits under the wetland. Analysis of the hydrologic balance of the fen from October 1985 through September 1986 indicates that the inflow was 44 percent ground water, 38 percent wastewater, 11 percent runoff (storm sewer), and 7 percent precipitation. The fen outflow was 93 percent surface water and 7 percent evapotranspiration. Inflow to the marsh was 74 percent surface water, 21 percent ground water, and 5 percent precipitation. Outflow from the marsh was 94 percent surface water and 6 percent evapotranspiration. Wastewater contributed 74,996, and 81 percent of the total suspended solids, total phosphorus, and total ammonia plus organic nitrogen in the fen, respectively. Other chemical inputs were from the storm sewer, ground water, and atmospheric deposition. The fen was found to retain 34, 14, and 14 percent of the suspended solids, total phosphorus, and total ammonia plus organic nitrogen, respectively. The marsh retained 44, 18, and 22 percent of these three constituents, respectively.

  13. Cognitive and olfactory deficits in Machado-Joseph disease: a dopamine transporter study.

    PubMed

    Braga-Neto, Pedro; Felicio, Andre C; Hoexter, Marcelo Q; Pedroso, José Luiz; Dutra, Lívia Almeida; Alessi, Helena; Minett, Thaís; Santos-Galduroz, Ruth F; da Rocha, Antônio José; Garcia, Lucas A L; Bertolucci, Paulo Henrique F; Bressan, Rodrigo A; Barsottini, Orlando Graziani Povoas

    2012-08-01

    Cognitive and olfactory impairments have been demonstrated in patients with Machado-Joseph disease (MJD), and a possible relationship with dopaminergic dysfunction is implicated. However, there is still controversy regarding the pattern of striatal dopaminergic dysfunction in patients with MJD. In this study, we investigated whether these patients had different dopamine transporter (DAT) densities as compared to healthy subjects, and correlated these data with cognitive performance and sense of smell. Twenty-two MJD patients and 20 control subjects were enrolled. The neuropsychological assessment comprised the spatial span, symbol search, picture completion, stroop color word test, trail making test and phonemic verbal fluency test. The 16-item Sniffin' Sticks was used to evaluate odor identification. DAT imaging was performed using the SPECT radioligand [(99m)Tc]-TRODAT-1, alongside with Magnetic Resonance imaging. Patients with MJD showed significantly lower DAT density in the caudate (1.34 ± 0.27 versus 2.02 ± 0.50, p < 0.001), posterior putamen (0.81 ± 0.32 versus 1.32 ± 0.34, p < 0.001) and anterior putamen (1.10 ± 0.31 versus 1.85 ± 0.45, p < 0.001) compared with healthy controls. The putamen/caudate ratio was also significantly lower in patients compared with controls (0.73 ± 0.038 versus 0.85 ± 0.032, p = 0.027). Even though we had only two patients with parkinsonism, we detected striatal dopaminergic deficits in those patients. No significant correlations were detected between DAT density and cognitive performance or Sniffin' Sticks scores. The data suggests that striatal dopamine deficit is not involved in cognitive or sense of smell deficits. This finding raises the possibility of extra-striatal dopamine and other neurotransmitter system involvement or of cerebellum neurodegeneration exerting a direct influence on cognitive and sensorial information processing in MJD. PMID:22575233

  14. PREFACE: SANS-YuMO User Meeting at the Start-up of Scientific Experiments on the IBR-2M Reactor: Devoted to the 75th anniversary of Yu M Ostanevich's birth

    NASA Astrophysics Data System (ADS)

    Gordely, Valentin; Kuklin, Alexander; Balasoiu, Maria

    2012-03-01

    The Second International Workshop 'SANS-YuMO User Meeting at the Start-up of Scientific Experiments on the IBR-2M Reactor', devoted to the 75th anniversary of the birth of Professor Yu M Ostanevich (1936-1992), an outstanding neutron physicist and the founder of small-angle neutron scattering (field, group, and instrument) at JINR FLNPh, was held on 27-30 May at the Frank Laboratory of Neutron Physics. The first Workshop was held in October 2006. Research groups from different neutron centers, universities and research institutes across Europe presented more than 35 oral and poster presentations describing scientific and methodological results. Most of them were obtained with the help of the YuMO instrument before the IBR-2 shutdown in 2006. For the last four years the IBR-2 reactor has been shut down for refurbishment. At the end of 2010 the physical launch of the IBR-2M reactor was finally realized. Nowadays the small-angle neutron scattering (SANS) technique is applied to a wide range of scientific problems in condensed matter, soft condensed matter, biology and nanotechnology, and despite the fact that there are currently over 30 SANS instruments in operation worldwide at both reactor and spallation sources, the demand for beam-time is considerably higher than the time available. It must be remembered, however, that as the first SANS machine on a steady-state reactor was constructed at the Institute Laue Langevin, Grenoble, the first SANS instrument on a 'white' neutron pulsed beam was accomplished at the Joint Institute for Nuclear Research at the IBR-30 reactor, beamline N5. During the meeting Yu M Ostanevich's determinative and crucial contribution to the construction of spectrometers at the IBR-2 high-pulsed reactor was presented, as well as his contribution to the development of the time-of-flight (TOF) small-angle scattering technique, and a selection of other scientific areas. His leadership and outstanding scientific achievements in applications of the

  15. M

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    M7 is an open or galactic cluster in the constellation Scorpius. It is easily visible with the unaided eye some degrees northeast of Shaula (λ Scorpii) and was first mentioned by Ptolemy in AD 130 (his mention might also include the nearby M6). Hence the cluster is often referred to as `Ptolemy's Cluster'. It was included in the published lists of nebulous and stellar objects by Hodierna (around ...

  16. 75 FR 73135 - Southern Nuclear Operating Company, Inc. Joseph M. Farley Nuclear Plant, Environmental Assessment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-29

    ... in the amount of design work required, design product loss due to computer hardware failures, and... project related to certain requirements in 10 CFR 73.55. Specifically, the request is to extend the..., this 19th day of November, 2010. For the Nuclear Regulatory Commission. Robert E. Martin, Sr....

  17. 77 FR 14441 - Facility Operating License Amendment From Southern Nuclear Operating, Inc., Joseph M. Farley...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-09

    ... entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR... System (ADAMS): You may access publicly available documents online in the NRC Library at http://www.nrc...) purification system may be connected to the RWST's seismic piping by manual operation of a RWST...

  18. Wildlife Habitat Impact Assessment, Chief Joseph Dam Project, Washington : Project Report 1992.

    SciTech Connect

    Kuehn, Douglas; Berger, Matthew

    1992-01-01

    Under the Pacific Northwest Electric Power Planning and Conservation Act of 1980, and the subsequent Northwest Power Planning Council`s Columbia River Basin Fish and Wildlife Program, a wildlife habitat impact assessment and identification of mitigation objectives have been developed for the US Army Corps of Engineer`s Chief Joseph Dam Project in north-central Washington. This study will form the basis for future mitigation planning and implementation.

  19. Administration of Vincristine in a Patient with Machado-Joseph Disease

    PubMed Central

    Colpo, Anna; Wilson, Frederick H.; Nardi, Valentina; Hochberg, Ephraim

    2012-01-01

    Chemotherapy-induced peripheral neurotoxicity is a major problem because it represents the dose-limiting side effect of a significant number of antineoplastic drugs, such as vinca alkaloids. Hereditary neuropathies usually predispose to severe vincristine neurotoxicity. Here, we report the case of a 56-year-old man with Machado-Joseph disease, also known as spinocerebellar ataxia type 3, treated with a vinca alkaloid without exacerbation of neurological symptoms. PMID:22433430

  20. Arthur Conan Doyle, Joseph Bell, and Sherlock Holmes. A neurologic connection.

    PubMed

    Westmoreland, B F; Key, J D

    1991-03-01

    Neurologists, like physicians in several other medical specialties, can lay claim to Sherlock Holmes as one of their own. This assertion is validated by the number of neurologic conditions, such as seizures, stroke, syncope, encephalopathies, and head trauma, that are mentioned in the stories and novels. In addition, the article reviews the powers of observation and the deductive approach utilized by Conan Doyle and Joseph Bell, the models for Sherlock Holmes, and how these skills can be applied to medical problems. PMID:2001191

  1. Astronaut Joseph Kerwin during EVA at Skylab 1 and 2 space station cluster

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot, performs extravehicular activity (EVA) at the Skylab 1 and 2 space station cluster in Earth orbit, as seen in this reproduction taken from a color television transmission made by a TV camera aboard the station. Kerwin is just outside the Airlock Module. Kerwin assisted Astronaut Charles Conrad Jr., Skylab 2 commander, during the successful EVA attempt to free the stuck solar array system wing on the Orbital Workshop.

  2. Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.

    PubMed

    Nóbrega, Clévio; Carmo-Silva, Sara; Albuquerque, David; Vasconcelos-Ferreira, Ana; Vijayakumar, Udaya-Geetha; Mendonça, Liliana; Hirai, Hirokazu; de Almeida, Luís Pereira

    2015-12-01

    Machado-Joseph disease is a progressive neurodegenerative disorder associated with the polyQ-expanded ataxin-3 (encoded by ATXN3), for which no therapy is available. With the aim of clarifying the mechanism of neurodegeneration, we hypothesized that the abnormally long polyQ tract would interact aberrantly with ataxin-2 (encoded by ATXN2), another polyQ protein whose function has recently been linked to translational regulation. Using patient's samples and cellular and animal's models we found that in Machado-Joseph disease: (i) ataxin-2 levels are reduced; and (ii) its subcellular localization is changed towards the nucleus. Restoring ataxin-2 levels by lentiviral-mediated overexpression: (i) reduced mutant ataxin-3 levels; and (ii) rescued behaviour defects and neuropathology in a transgenic mouse model of Machado-Joseph disease. Conversely (i) mutating the ataxin-2 motif that enables binding to its natural interactor and translation activator poly(A)-binding protein; or (ii) overexpressing poly(A)-binding protein, had opposite effects, increasing mutant ataxin-3 translation and aggregation. This work suggests that in Machado-Joseph disease, mutant ataxin-3 drives an abnormal reduction of ataxin-2 levels, which overactivates poly(A)-binding protein, increases translation of mutant ataxin-3 and other proteins and aggravates Machado-Joseph disease. Re-establishment of ataxin-2 levels reduces mutant ataxin-3 and alleviates Machado-Joseph disease pathogenesis opening a new avenue for therapeutic intervention in this and potentially other polyQ disorders. PMID:26490332

  3. Joseph Warren: a discussion of his life and analysis of his death.

    PubMed

    Holland, Ryan; Sabourin, Victor M; Gandhi, Chirag D; Carmel, Peter W; Prestigiacomo, Charles J

    2015-07-01

    As his fellow soldiers ran past him, Joseph Warren stood bravely on Bunker Hill. It was June 17, 1775, and British troops were fighting the colonists in one of the early battles of the American Revolution. The British had already attempted two major assaults that day, and the third would end with Warren's death. He was a medical doctor, public figure, and general who spent his life and last living moments fighting for freedom for the American colonists. After the battle, there was much confusion about what had happened to Joseph Warren. Some thought he had survived the battle; other accounts differed on how exactly he had died. The details of the events on Bunker Hill remained a mystery until the following year, when Paul Revere helped identify Warren's body by the false teeth that had been implanted years earlier. Warren's remains showed that his head had been struck by a bullet. Analysis of the skull helped to sift through the differing tales of Warren's death and thus unveil the truth about what occurred that day. The smaller bullet wound in the left maxilla suggests that he was not shot while retreating with the rest of the soldiers. The larger exit wound in the right occiput illustrates that the bullet's trajectory crossed the midline of the brain and most likely injured the brainstem. Therefore, contrary to rumors that circulated at the time, Joseph Warren most likely was killed instantly at the Battle of Bunker Hill while heroically facing his enemy. PMID:26126399

  4. Machado–Joseph disease in a Nigerian family: mutational origin and review of the literature

    PubMed Central

    Ogun, Shamsideen Abayomi; Martins, Sandra; Adebayo, Philip B; Dawodu, Clara O; Sequeiros, Jorge; Finkel, Michael F

    2015-01-01

    Machado–Joseph disease (MJD) has been described in Africans, but no cases have been reported from Nigeria. Current MJD global distribution results from both the ancestral populations-of-origin and the founder effects of mutations, some as a consequence of the Portuguese sea travels in the 15th to 16th century. Two main ancestral haplotypes have been identified: the Machado lineage, which is more recent, predominant in families of Portuguese extraction, and the Joseph lineage, which is much older and worldwide spread, postulated to have an Asian origin. We report a Nigerian family with MJD from Calabar, once settled by Portuguese slave traders, and assessed its mutational origin. The proband was a 33-year-old man with progressive unsteady gait, weakness of all limbs, dysphagia, dysarthria, urinary frequency and diaphoresis. He had end-of-gaze nystagmus, spastic quadriparesis and atrophic small muscles of the hand. He showed fibrillation potentials on EMG, and nerve conduction studies suggested a central axonopathy without demyelination. This family bears the Joseph haplotype, which has a founder effect in the island of Flores, in the Azores (and their descendants in North-America), but is also the most common in non-Portuguese populations worldwide, with an estimated mutation age of around 7000 years. PMID:24781759

  5. Determination of neutron flux density distribution in the core with LEU fuel IRT-4M at the training reactor VR-1

    SciTech Connect

    Huml, O.

    2008-07-15

    The objective of this work was to determine the neutron flux density distribution in various places of the training reactor VR-1 Sparrow. This experiment was performed on the new core design C1, composed of the new low-enriched uranium fuel cells IRT-4M (19.7 %). This fuel replaced the old high-enriched uranium fuel IRT-3M (36 %) within the framework of the RERTR Program in September 2005. The measurement used the neutron activation analysis method with gold wires. The principle of this method consists in neutron capture in a nucleus of the material forming the activation detector. This capture can change the nucleus in a radioisotope, whose activity can be measured. The absorption cross-section values were evaluated by MCNP computer code. The gold wires were irradiated in seven different positions in the core C1. All irradiations were performed at reactor power level 1E8 (1 kW{sub therm}). The activity of segments of irradiated wires was measured by special automatic device called 'Drat' (Wire in English). (author)

  6. Optimization of a moderator-neutron guide system for diffractometers of beam line 7A of the IBR-2M reactor

    NASA Astrophysics Data System (ADS)

    Manoshin, S. A.; Belushkin, A. V.; Kulikov, S. A.; Shabalin, E. P.; Walther, K.; Scheffzuek, C.; Zhuravlev, V. V.

    2009-09-01

    Neutron guides are widely used to transport the neutrons from the moderator to the sample. Due to the constructive features of the ring corridor of the fast pulsed reactor IBR-2, the minimal distance between the moderator and the guide entrance is around 6 m. The main goal of the paper is to optimize the neutron optical system between the moderator and the entrance of the new neutron guides. Using Monte Carlo simulations we calculate the possible best gain of the neutron flux density at the guide exit. After the described optimization process, the optimal system is obtained. The recommendations for construction of the new beam line are provided too. Similar technique and the proposed system could be easily adapted for another similar beam line at the neutron sources.

  7. HEU Measurements of Holdup and Recovered Residue in the Deactivation and Decommissioning Activities of the 321-M Reactor Fuel Fabrication Facility at the Savannah River Site

    SciTech Connect

    DEWBERRY, RAYMOND; SALAYMEH, SALEEM R.; CASELLA, VITO R.; MOORE, FRANK S.

    2005-03-11

    This paper contains a summary of the holdup and material control and accountability (MC&A) assays conducted for the determination of highly enriched uranium (HEU) in the deactivation and decommissioning (D&D) of Building 321-M at the Savannah River Site (SRS). The 321-M facility was the Reactor Fuel Fabrication Facility at SRS and was used to fabricate HEU fuel assemblies, lithium-aluminum target tubes, neptunium assemblies, and miscellaneous components for the SRS production reactors. The facility operated for more than 35 years. During this time thousands of uranium-aluminum-alloy (U-Al) production reactor fuel tubes were produced. After the facility ceased operations in 1995, all of the easily accessible U-Al was removed from the building, and only residual amounts remained. The bulk of this residue was located in the equipment that generated and handled small U-Al particles and in the exhaust systems for this equipment (e.g., Chip compactor, casting furnaces, log saw, lathes A & B, cyclone separator, Freon{trademark} cart, riser crusher, ...etc). The D&D project is likely to represent an important example for D&D activities across SRS and across the Department of Energy weapons complex. The Savannah River National Laboratory was tasked to conduct holdup assays to quantify the amount of HEU on all components removed from the facility prior to placing in solid waste containers. The U-235 holdup in any single component of process equipment must not exceed 50 g in order to meet the container limit. This limit was imposed to meet criticality requirements of the low level solid waste storage vaults. Thus the holdup measurements were used as guidance to determine if further decontamination of equipment was needed to ensure that the quantity of U-235 did not exceed the 50 g limit and to ensure that the waste met the Waste Acceptance Criteria (WAC) of the solid waste storage vaults. Since HEU is an accountable nuclear material, the holdup assays and assays of recovered

  8. A 325-year reconstruction of St. Joseph River streamflow using tree rings

    NASA Astrophysics Data System (ADS)

    Schmidt, Karly R.

    The use of tree ring widths as indicators of water resource availability affords annual-scale resolution in the reconstruction of streamflow prior to the limited instrumental record. While an abundance of streamflow reconstructions have been conducted in the western United States, few have been undertaken in the eastern half of the country. This study aims to enhance understanding of regional hydroclimate in the Great Lakes region by presenting a 325-year streamflow reconstruction for the St. Joseph River, as well as contributing two new tree ring-width chronologies in Indiana and Michigan. A variety of factors potentially influencing the chance of successful streamflow reconstruction are also posited and discussed. A total of 55 tree ring width chronologies from Indiana, Illinois, Michigan, Wisconsin, and Ontario were examined using standard methods in dendrochronology and nested principal component analysis (PCA) to reconstruct St. Joseph River streamflow to 1675 with greater skill than climatology. The resulting overall reconstruction and periods identified as severe droughts and pluvials were in general agreement with other dendroclimatological studies in the eastern U.S. The findings suggest that the instrumental record (beginning in 1924) does not accurately depict long-term streamflow variability of the St. Joseph River. The reconstructed values tend to overestimate the intensity and duration of pluvial periods, but also show that droughts in the region were of similar intensity to those in the more recent past, but were of longer duration. This suggests that water resource managers may need to consider a wider range of variability than previously indicated by the instrumental record.

  9. Decoupling the Stationary Navier-Stokes-Darcy System with the Beavers-Joseph-Saffman Interface Condition

    DOE PAGESBeta

    Cao, Yong; Chu, Yuchuan; He, Xiaoming; Wei, Mingzhen

    2013-01-01

    This paper proposes a domain decomposition method for the coupled stationary Navier-Stokes and Darcy equations with the Beavers-Joseph-Saffman interface condition in order to improve the efficiency of the finite element method. The physical interface conditions are directly utilized to construct the boundary conditions on the interface and then decouple the Navier-Stokes and Darcy equations. Newton iteration will be used to deal with the nonlinear systems. Numerical results are presented to illustrate the features of the proposed method.

  10. The Forgotten Forefather: Joseph James Kinyoun and the Founding of the National Institutes of Health

    PubMed Central

    Morens, David M.; Fauci, Anthony S.

    2012-01-01

    ABSTRACT In celebrating the 125th anniversary of the National Institutes of Health (NIH) in August 2012, NIH has been examining its origins, its history, and the visionary men and women whose research have contributed to the saving and/or improving the quality of life of millions of people throughout the world. This minireview examines Joseph James Kinyoun (1860 to 1919), the 1887 founder of a federal Hygienic Laboratory that is considered the direct ancestor of the modern NIH, and explores the development of NIH as it was shaped by, and in turn shaped, the new field of microbiology. PMID:22736540