Gillmor, C. Stewart
Technology, it is said, is more parochial than science. In this view, technology is constructed by specific cultures to fit specific needs: while the science of physics is universal, there are a thousand ways to dig dirt from the ground or to build a house. But is this true? In his book, Friedman shows us that at least the study of science is approached differently from one culture to another and that social, political, and economic aspects lead one people or nation or world region to emphasize different areas of science. From Per Kalm (a Swedish naturalist who collected auroral observations before 1750) to Hannes Alfven, the Scandinavians have studied the Northern sea and the Northern sky.
[Metastatic prostate cancer complicated with chronic disseminated intravascular coagulopathy causing acute renal failure, mimicking thrombotic thrombocytopenic purpura and hemolytic uremic syndrome: pathomechanism, differential diagnosis and therapy related to a case].
Deme, Dániel; Ragán, Márton; Kalmár, Katalin; Kovács, Lajos; Varga, Erzsébet; Varga, Tünde; Rakonczai, Ervin
in the peripheral blood), normal INR, elevated lactate dehydrogenase (LDH) and ARF suggested TTP-HUS. Hemodialysis and six plasmaferesis (PF) were carried out. After the fifth PF, skin manifestations of thrombotic microangiopathy occurred on the feet. Clotting analysis revealed elevated D-dimer (>5 μg/mL), normal fibrinogen (3.2 g/L), a slightly raised INR (1.36) and activated partial prothrombin time (APTT) (45.8 sec), normal reticulocyte (57 G/L) and a slightly low platelet count (123 G/L), which proved to be chronic DIC. Therapeutic dose of low-molecular-weight heparin (LMWH) was started. Elevated prostate-specific antigen (PSA) (109.6 ng/mL) suggested prostatic carcinoma. Prostate biopsy revealed adenocarcinoma (Gleason: 4+4 for left lobe and 3+3 for right lobe). Elevated alkaline phosphatase suggested metastases in the bone, which were confirmed by bone scintigraphy. Combined androgen blockade (CAB) was started. After three months follow-up our patient's status is satisfactory. PSA is in the normal range (4.6 ng/mL). Thrombocytopenia of uncertain origin with normal or raised INR, APTT, elevated D-dimer, normal fibrinogen and reticulocyte count prove the diagnosis of chronic DIC. This process warrants searching for metastatic neoplasia. Due to the relatively low serum levels of circulating procoagulant factors (e.g. tissue factor), therapeutic dose of LMWH can be used with good efficiency in chronic DIC with low risk of bleeding. Severe DIC as a complication of metastatic prostate cancer can be treated by androgen deprivation therapy (ADT) or CAB in combination with ketokonazole and concomitant use of supportive treatment. Deme D, Ragán M, Kovács L, Kalmár K, Varga E, Varga T, Rakonczai E. Metastatic prostate cancer complicated with chronic disseminated intravascular coagulopathy causing acute renal failure mimicking thrombotic thrombocytopenic purpura and hemolytic uremic syndrome: pathomechanism, differential diagnosis and therapy related to a case. PMID
Speziale, S.; Bruschini, E.; Andreozzi, G. B.; Bosi, F.; Hålenius, U.
Spinels are a subject of intense research in solid state physics, materials science and geosciences. Their general formula is T(A1-i)M(AiB2-i)X4 (A and B are cations, X are anions, T and M indicate tetrahedrally- and octahedrally-coordinated sites and i is the inversion degree). They are ideal materials to study the interplay between chemical substitutions, structure and the physical properties of solids. As spinel-structured ringwoodite (Mg,Fe)2SiO4 is the most abundant mineral in the lower transition zone, understanding the effect of chemical substitution on the elastic properties of spinels is of crucial for geophysics. We have experimentally studied the variation of the elastic properties along the join MgAl2O4 - MnAl2O4. Crystals of 4 compositions along the join were synthesized at the very same experimental conditions and their crystal chemistry was fully characterized. Single-crystal elastic constants Cij of all the samples were measured by Brillouin spectroscopy at ambient conditions. For compositions with Mn/Mg < 0.5 C11 remains constant, then it decreases of ~4% for higher Mn contents. From MgAl2O4 to MnAl2O4 C12 lineraly increases ~ 5% and C44 decreases ~ 20% . The bulk modulus KS is almost constant, whereas the shear modulus G decreases ~ 18% across the join. The elastic constants of MnAl2O4 are C11 = 271.3 (± 1.3) GPa, C12 = 164.8 (± 1.3) GPa and C44 = 124.9 (5) GPa. Using the empirical polyhedral approach  we have inferred the effectve polyhedral bulk moduli of Mg, Mn and Al in T and M sites. We observe that KMnM < KMgM < KMgT ≈ KMnT < KAlM << KAlT. The relationship between polyhedral moduli and ionic potential IP  can be expressed as Ki j (GPa) = 20 ( ± 2) × IP + 108 (± 10), where i is the cation, j is the site and IP is in units of (e/Å). Using our correlation and atomic radii from  we successfully reproduced the bulk modulus of different oxide spinels with bi- and tri-valent cations. Our preliminary results confirm that empirical
Kalvans, Andis; Hang, Tiit
solely by the basin depth and duration of the ice cover period. A normal grading is observed in most of the studied winter layers of individual varves. Relatively large errors in the estimated terminal grain size permits only to conclude that it is in line with previously reconstructed water depth constrained by the maximum possible duration of the lake ice cover. The research is supported by the European Union through the ESF Mobilitas grant No MJD309. References Hang, T., Kohv, M. 2013. Glacial varves at Pärnu, south-western Estonia: a local varve chronology and proglacial sedimentary environment. GFF, June, 37-41. doi:10.1080/11035897.2013.775598 Rosentau, A., Vassiljev, J., Hang, T., Saarse, L., Kalm, V. 2009. Development of the Baltic Ice Lake in the eastern Baltic. Quaternary International, 206(1-2), 16-23. doi:10.1016/j.quaint.2008.10.005