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1

Vanderbilt researchers find a protein family key to aging, cancer:  

Cancer.gov

The list of aging-associated proteins known to be involved in cancer is growing longer, according to research by investigators at Vanderbilt-Ingram Cancer Center and the National Institutes of Health. The new study, published Oct. 17 in Cancer Cell, identifies the protein SIRT2 as a tumor suppressor linked to gender-specific tumor development in mice. Along with two other "sirtuin" proteins previously linked to cancer, the new finding suggests the existence of a rare "family" of tumor suppressors.

2

Alcoholics Anonymous: Key Research Findings from 2002–2007  

Microsoft Academic Search

Alcoholics Anonymous (AA) and other 12-step programs represent an affordable and widely accessible community-based resource for the estimated 18 million Americans with alcohol-related disorders. While substantiating information regarding 12-step programs remains challenging due to their autonomous structure and emphasis on anonymity, an ever increasing body of research provides a wealth of data regarding AA's efficacy, mechanisms of change, and viability

Shulamith Lala Ashenberg Straussner; Helga Byrne

2009-01-01

3

Fox Chase researchers find a compound that targets a key mechanism behind lymphoma  

Cancer.gov

Scientists at Fox Chase Cancer Center in Philadelphia have come one step closer to developing the first treatment to target a key pathway in lymphoma. The new findings were announced at the American Association for Cancer Research Annual Meeting 2012 on Tuesday, April 3.

4

Research on Self-Determination in Physical Education: Key Findings and Proposals for Future Research  

ERIC Educational Resources Information Center

Background: During the last 30 years, several theories of motivation have generated insights into the motives underlying learners' behavior in physical education. Self-determination theory (SDT), a general theory on social development and motivation, has enjoyed increasing popularity in physical education research during the past decade. SDT…

Van den Berghe, Lynn; Vansteenkiste, Maarten; Cardon, Greet; Kirk, David; Haerens, Leen

2014-01-01

5

Myalgic encephalomyelitis: a review with emphasis on key findings in biomedical research  

PubMed Central

This review examines research findings in patients with myalgic encephalomyelitis in light of the current debate about this chronic multiple?symptom, multiorgan, multisystem illness and the conflicting views in medicine. These issues cannot be separated from the political opinions and assertions that conflict with science and medicine, and will be part of this review as they have enormous consequences for scientific and medical research, patients, clinicians, carers and policy makers. PMID:16935967

Hooper, M

2007-01-01

6

Student Engagement and Student Outcomes: Key Findings from "CCSSE" Validation Research  

ERIC Educational Resources Information Center

The findings from 20 years of research on undergraduate education have been unequivocal: The more actively engaged students are--with college faculty and staff, with other students, and with the subject matter they study--the more likely they are to learn, to stick with their studies, and to attain their academic goals. The existing literature,…

McClenney, Kay; Marti, C. Nathan; Adkins, Courtney

2012-01-01

7

Research in Online and Blended Learning in the Business Disciplines: Key Findings and Possible Future Directions  

ERIC Educational Resources Information Center

In this literature review, we examine and assess the state of research of online and blended learning in the business disciplines with the intent of assessing the state of the field and identifying opportunities for meaningful future research. We review research from business disciplines such as Accounting, Economics, Finance, Information Systems…

Arbaugh, J. B.; Godfrey, Michael R.; Johnson, Marianne; Pollack, Birgit Leisen; Niendorf, Bruce; Wresch, William

2009-01-01

8

Key Findings This research was funded by the Office of the Assistant  

E-print Network

or friends among poor and near-poor families. We find: · About 1 in 7 households (14.2%) report 2008 income not experience unemployment over this period. 1. Government programs include the Earned Income Tax Credit (EITC

Edwards, Paul N.

9

Powering Down: Green IT in Higher Education. Key Findings  

ERIC Educational Resources Information Center

This document presents the key findings from "Powering Down: Green IT in Higher Education," the 2010 ECAR (EDUCAUSE Center for Applied Research) study of green IT. The study examines the stance institutions and their central IT organizations are taking on environmental sustainability (ES), the progress they are making on a variety of key

Sheehan, Mark C.

2010-01-01

10

Key findings of the national weatherization evaluation  

SciTech Connect

In 1990, the U.S. Department of Energy sponsored a comprehensive evaluation of its Weatherization Assistance Program, the nation`s largest residential energy conservation program. The primary goal of the evaluation was to establish whether the Program meets the objectives of its enabling legislation and fulfills its mission statement, to reduce the heating and cooling costs for low-income families-particularly the elderly, persons with disabilities, and children by improving the energy-efficiency of their homes and ensuring their health and safety. Oak Ridge National Laboratory managed a five-part study which produced a series of documents evaluating the Program. The objective of this document is to summarize the findings of the five-part National Weatherization Evaluation. The five studies were as follows: (1) Network Study-this study characterized the weatherization network`s leveraging, capabilities, procedures, staff, technologies, and innovations; (2) Resources and Population Study-this study profiled low-income weatherization resources, the weatherized population, and the population remaining to be served; (3) Multifamily Study-this study described the nature and extent of weatherization activities in larger multifamily buildings; (4) Single-family Study-this study estimated the national savings and cost- effectiveness of weatherizing single-family and small multifamily dwellings that use natural gas or electricity for space heating; (5) Fuel-Oil Study-this study estimated the savings and cost-effectiveness of weatherizing single-family homes, located in nine northeastern states, that use fuel oil for space heating. This paper provides a brief overview of each study`s purposes, research methods and most important findings.

Brown, M.A.; Berry, L.G.

1994-10-01

11

Breast Cancer Research Finding Answers. Finding Cures.  

E-print Network

Breast Cancer Research Finding Answers. Finding Cures. Thanks to improvements in treatment and early detection, more and more women are surviving breast cancer. In fact, the five-year survival rate for women with breast cancer today is 90%, up from only 63% in the 1960s. While progress has clearly been

Kowalczykowski, Stephen C.

12

Perceptual Tests of an Algorithm for Musical Key-Finding  

Microsoft Academic Search

Perceiving the tonality of a musical passage is a fundamental aspect of the experience of hearing music. Models for determining tonality have thus occupied a central place in music cognition research. Three experiments investigated 1 well-known model of tonal determination: the Krumhansl-Schmuckler key-finding algorithm. In Experiment 1, listeners' percepts of tonality following short musical fragments derived from preludes by Bach

Mark A. Schmuckler; Robert Tomovski

2005-01-01

13

Knowledge translation of research findings  

PubMed Central

Background One of the most consistent findings from clinical and health services research is the failure to translate research into practice and policy. As a result of these evidence-practice and policy gaps, patients fail to benefit optimally from advances in healthcare and are exposed to unnecessary risks of iatrogenic harms, and healthcare systems are exposed to unnecessary expenditure resulting in significant opportunity costs. Over the last decade, there has been increasing international policy and research attention on how to reduce the evidence-practice and policy gap. In this paper, we summarise the current concepts and evidence to guide knowledge translation activities, defined as T2 research (the translation of new clinical knowledge into improved health). We structure the article around five key questions: what should be transferred; to whom should research knowledge be transferred; by whom should research knowledge be transferred; how should research knowledge be transferred; and, with what effect should research knowledge be transferred? Discussion We suggest that the basic unit of knowledge translation should usually be up-to-date systematic reviews or other syntheses of research findings. Knowledge translators need to identify the key messages for different target audiences and to fashion these in language and knowledge translation products that are easily assimilated by different audiences. The relative importance of knowledge translation to different target audiences will vary by the type of research and appropriate endpoints of knowledge translation may vary across different stakeholder groups. There are a large number of planned knowledge translation models, derived from different disciplinary, contextual (i.e., setting), and target audience viewpoints. Most of these suggest that planned knowledge translation for healthcare professionals and consumers is more likely to be successful if the choice of knowledge translation strategy is informed by an assessment of the likely barriers and facilitators. Although our evidence on the likely effectiveness of different strategies to overcome specific barriers remains incomplete, there is a range of informative systematic reviews of interventions aimed at healthcare professionals and consumers (i.e., patients, family members, and informal carers) and of factors important to research use by policy makers. Summary There is a substantial (if incomplete) evidence base to guide choice of knowledge translation activities targeting healthcare professionals and consumers. The evidence base on the effects of different knowledge translation approaches targeting healthcare policy makers and senior managers is much weaker but there are a profusion of innovative approaches that warrant further evaluation. PMID:22651257

2012-01-01

14

Public key infrastructure for DOE security research  

SciTech Connect

This document summarizes the Department of Energy`s Second Joint Energy Research/Defence Programs Security Research Workshop. The workshop, built on the results of the first Joint Workshop which reviewed security requirements represented in a range of mission-critical ER and DP applications, discussed commonalties and differences in ER/DP requirements and approaches, and identified an integrated common set of security research priorities. One significant conclusion of the first workshop was that progress in a broad spectrum of DOE-relevant security problems and applications could best be addressed through public-key cryptography based systems, and therefore depended upon the existence of a robust, broadly deployed public-key infrastructure. Hence, public-key infrastructure ({open_quotes}PKI{close_quotes}) was adopted as a primary focus for the second workshop. The Second Joint Workshop covered a range of DOE security research and deployment efforts, as well as summaries of the state of the art in various areas relating to public-key technologies. Key findings were that a broad range of DOE applications can benefit from security architectures and technologies built on a robust, flexible, widely deployed public-key infrastructure; that there exists a collection of specific requirements for missing or undeveloped PKI functionality, together with a preliminary assessment of how these requirements can be met; that, while commercial developments can be expected to provide many relevant security technologies, there are important capabilities that commercial developments will not address, due to the unique scale, performance, diversity, distributed nature, and sensitivity of DOE applications; that DOE should encourage and support research activities intended to increase understanding of security technology requirements, and to develop critical components not forthcoming from other sources in a timely manner.

Aiken, R.; Foster, I.; Johnston, W.E. [and others

1997-06-01

15

Human Health Effects of Tetrachloroethylene: Key Findings and Scientific Issues  

PubMed Central

Background: The U.S. Environmental Protection Agency (EPA) completed a toxicological review of tetrachloroethylene (perchloroethylene, PCE) in February 2012 in support of the Integrated Risk Information System (IRIS). Objectives: We reviewed key findings and scientific issues regarding the human health effects of PCE described in the U.S. EPA’s Toxicological Review of Tetrachloroethylene (Perchloroethylene). Methods: The updated assessment of PCE synthesized and characterized a substantial database of epidemiological, experimental animal, and mechanistic studies. Key scientific issues were addressed through modeling of PCE toxicokinetics, synthesis of evidence from neurological studies, and analyses of toxicokinetic, mechanistic, and other factors (tumor latency, severity, and background rate) in interpreting experimental animal cancer findings. Considerations in evaluating epidemiological studies included the quality (e.g., specificity) of the exposure assessment methods and other essential design features, and the potential for alternative explanations for observed associations (e.g., bias or confounding). Discussion: Toxicokinetic modeling aided in characterizing the complex metabolism and multiple metabolites that contribute to PCE toxicity. The exposure assessment approach—a key evaluation factor for epidemiological studies of bladder cancer, non-Hodgkin lymphoma, and multiple myeloma—provided suggestive evidence of carcinogenicity. Bioassay data provided conclusive evidence of carcinogenicity in experimental animals. Neurotoxicity was identified as a sensitive noncancer health effect, occurring at low exposures: a conclusion supported by multiple studies. Evidence was integrated from human, experimental animal, and mechanistic data sets in assessing adverse health effects of PCE. Conclusions: PCE is likely to be carcinogenic to humans. Neurotoxicity is a sensitive adverse health effect of PCE. Citation: Guyton KZ, Hogan KA, Scott CS, Cooper GS, Bale AS, Kopylev L, Barone S Jr, Makris SL, Glenn B, Subramaniam RP, Gwinn MR, Dzubow RC, Chiu WA. 2014. Human health effects of tetrachloroethylene: key findings and scientific issues. Environ Health Perspect 122:325–334;?http://dx.doi.org/10.1289/ehp.1307359 PMID:24531164

Hogan, Karen A.; Scott, Cheryl Siegel; Cooper, Glinda S.; Bale, Ambuja S.; Kopylev, Leonid; Barone, Stanley; Makris, Susan L.; Glenn, Barbara; Subramaniam, Ravi P.; Gwinn, Maureen R.; Dzubow, Rebecca C.; Chiu, Weihsueh A.

2014-01-01

16

Students' views of retail employment – key findings from Generation Ys  

Microsoft Academic Search

Purpose – The aim of this paper is to highlight some preliminary findings regarding students' perceptions of retail employment. It concentrates on those students who belong to Generation Y, those born between 1977 and 1994. Design\\/methodology\\/approach – The research instrument consisted of a questionnaire survey administered to business studies students at two Scottish universities – Glasgow Caledonian University and Stirling

Adelina M. Broadbridge; Gillian A. Maxwell; Susan M. Ogden

2007-01-01

17

Research on Key Technologies of Virtual Endoscopy  

Microsoft Academic Search

Key techniques on virtual endoscopy are researched in this paper. We use boundary model and local feature structure to realize tissue segmentation. A new efficient algorithm is presented to solve path planning based on distance transform. As for real-time processing, a frame in virtual endoscopy is divided into near viewpoint part and far viewpoint part based on volume data characteristics

Peng Yang-jun; Wang Yuan-hong; Shi Jiao-ying

2010-01-01

18

ReportingResearchFindings 44Reporting Research Findings  

E-print Network

that an overwhelming percentage of the respondents -- 83% -- feel that punishing cyberbullies is not necessary of reporting findings Yes No 21% 79% Yes No 21% 79% Figure 2: Percentage of respondents who know how to do CPR of knowledge of CPR As can be seen from Figure 2, only 21% of the respondents reported knowing how

Chaudhuri, Sanjay

19

Alternative IT Sourcing Strategies: From the Campus to the Cloud. ECAR Key Findings  

ERIC Educational Resources Information Center

This document presents the key findings from the 2009 ECAR (EDUCAUSE Center for Applied Research) study, "Alternative IT Sourcing Strategies: From the Campus to the Cloud," by Philip J. Goldstein. The study explores a multitude of strategies used by colleges and university information technology organizations to deliver the breadth of technologies…

Goldstein, Philip J.

2009-01-01

20

The ECAR Study of Undergraduate Students and Information Technology, 2010. Key Findings  

ERIC Educational Resources Information Center

This document presents the key findings from "The ECAR Study of Undergraduate Students and Information Technology, 2010". Since 2004, the annual ECAR (EDUCAUSE Center for Applied Research) study of undergraduate students and information technology has sought to shed light on how information technology affects the college experience. We ask…

Smith, Shannon D.; Caruso, Judith Borreson

2010-01-01

21

Can Recent Innovations in Harmonic Analysis `Explain' Key Findings in Natural Image Statistics?  

E-print Network

of this hypothesis, looking at key findings of the NSS literature and conducting studies of curvelet and ridgelet: Network: Comput. Neural Syst. #12;2 Acknowledgments. This research was supported by National Science hypotheses. � In the 1970's, there were claims that certain early stages of the human visual system acted

Donoho, David

22

Editorial Decisions May Perpetuate Belief in Invalid Research Findings  

PubMed Central

Social psychology and related disciplines are seeing a resurgence of interest in replication, as well as actual replication efforts. But prior work suggests that even a clear demonstration that a finding is invalid often fails to shake acceptance of the finding. This threatens the full impact of these replication efforts. Here we show that the actions of two key players – journal editors and the authors of original (invalidated) research findings – are critical to the broader public’s continued belief in an invalidated research conclusion. Across three experiments, we show that belief in an invalidated finding falls sharply when a critical failed replication is published in the same – versus different – journal as the original finding, and when the authors of the original finding acknowledge that the new findings invalidate their conclusions. We conclude by discussing policy implications of our key findings. PMID:24023863

Eriksson, Kimmo; Simpson, Brent

2013-01-01

23

A Mid-DESD Review: Key Findings and Ways Forward  

ERIC Educational Resources Information Center

This article lists the key outcomes and recommendations of Phase I of the monitoring and evaluation of the DESD. Phase I focused on a review of the structures, provisions and conditions countries and regions have put in place in order to facilitate the development and implementation of ESD. The author also touches upon the constraints and…

Wals, Arjen E. J.

2009-01-01

24

Intradistrict Resource Allocation: Key Findings and Policy Implications  

ERIC Educational Resources Information Center

The focus on school-level performance brought about by the No Child Left Behind Act--as well as recent court cases challenging the use of race in student assignment policies--has brought greater attention to the need to for careful study of the allocation of resources within school districts. This paper describes the policy context, reviews key

Houck, Eric A.

2011-01-01

25

Key Diagnostic Finding in a Condition with Variable Clinical Presentations  

PubMed Central

This is an interesting case series on a very common genetic condition which are often diagnosed late as clinical signs are inconspicuous. We would like to highlight the principal clinical examination finding which led to diagnosis. PMID:23984150

Sukumaran, Anju; Buchlis, John

2013-01-01

26

77 FR 52034 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013

...that Respondent engaged in research misconduct involving two...and HHS want to conclude this matter without further expenditure...Settlement Agreement to resolve this matter. Respondent neither admits nor denies ORI's finding of research misconduct. This...

2012-08-28

27

75 FR 18836 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary Findings of Research Misconduct...falsifying the original research data when entering values into computer programs for statistical analysis with the goal of...

2010-04-13

28

The National Television Violence Study: Key Findings and Recommendations.  

ERIC Educational Resources Information Center

Summarizes findings of the Television Violence Study indicating that the context of much television violence is dangerous to viewers, perpetrators go unpunished in the majority of programs, negative consequences of violence are often ignored, guns feature prominently, and presentation of violence differs greatly across networks and across…

Young Children, 1996

1996-01-01

29

Use of nursing practice research findings.  

PubMed

Fourteen nursing research findings that meet the Conduct and Utilization of Research in Nursing (CURN) Project (1982) criteria for clinical use were identified from research journals and CURN publications. Data collected from 216 practicing nurses in small, medium, and large hospitals were analyzed to determine their awareness of, persuasion about, and use of the findings. The majority of nurses were aware of the average innovation, were persuaded about it, and used the average innovation at least sometimes. Use of the innovations had no relationship to hospital policies or procedures concerning the nursing research findings. PMID:3671121

Brett, J L

1987-01-01

30

77 FR 38632 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary Findings of Research Misconduct...altering in multiple ways a single stereology ``.dat'' computer file generated on August 18, 2002, and renaming it to...

2012-06-28

31

Unlocking the Key to Undergraduate Research  

E-print Network

Opportunities Presentation EECS Undergraduate Matters Student Affairs Officer 510-642-1786 khutch #12;College Of Engineering Undergraduate Research Opportunities Page http://www.coe.berkeley.edu/current_students with graduate students! Increase your ability to do well in Graduate School! Why Do Undergraduate ResearchWhy Do

Romano, Raquel

32

Applications of classroom management research findings  

Microsoft Academic Search

The purpose of this study was to examine the long?term effects of providing a research?based approach to classroom management through a two?phase staff development process. Findings indicate that teachers identified specific benefits they gained from implementing group development and cooperative learning strategies. The findings also indicate that classrooms of high implementors differed from classrooms of low implementors. Finally, specific characteristics

Joyce G. Putnam

1985-01-01

33

Yucca Mountain Socioeconomic Project: The 1991 Nevada State telephone survey: Key findings  

SciTech Connect

The 1991 Nevada State Telephone Survey was implemented by Decision Research on behalf of the State of Nevada, Agency for Nuclear Projects/Nuclear Waste Project Office (NWPO) as part of an ongoing socioeconomic impact assessment study. The scope of this survey was considerably smaller than a previous survey conducted in 1989 and focused more upon public evaluations of the Yucca Mountain repository program and the trust Nevadans currently addressing the siting issues. In order to provide place in key public officials who are Longitudinal data on the repository program, the 1991 questionnaire consisted of questions that were used in the 1989 NWPO survey which was conducted by Mountain West Research. As a result, the findings from this survey are compared with analogous items from the 1989 survey, and with the results from a survey commissioned by the Las Vegas Review-Journal and reported in their issue of October 21, 1990. The Review-Journal survey was conducted by Bruce Merri11 of the Arizona State University Media Research Center. A more complete comparison of the 1989 and 1991 surveys sponsored by NWPO is possible since the researchers at Decision Research had access to both these databases. The only source of information for the Review-Journal findings was the articles published in the Fall, 1990. The findings of the 1991 survey show that Nevadans oppose the federal government attempts to locate a high-level radioactive waste repository at Yucca Mountain. They support a policy of opposition on the part of Nevada officials. They believe that Nevadans should have the final say in whether to accept the repository or not, and they reject the proposition that benefits from the repository program will outweigh the harms. These findings are very similar to survey results from 1989 and 1990 and once again demonstrate very widespread public opposition by Nevadans to the current federal repository program.

Flynn, J.H.; Mertz, C.K.; Slovic, P.

1991-05-01

34

Tools for Finding Indexed Accounting Research  

NSDL National Science Digital Library

The American Accounting Association (AAA) lists the print resources and electronic databases where AAA journals are indexed and abstracted at this Tools for Finding Indexed Accounting Research page. The detailed list includes indexing and abstracting devices for a number of journals -- Accounting Horizons, The Accounting Review, Auditing: A Journal of Practice & Theory, Behavioral Research in Accounting, Issues in Accounting Education, Journal of the American Taxation Association, Journal of Information Systems, and the Journal of Management Accounting Research -- with date coverage and full-text information included for each.

35

Research on Key Technologies of Cloud Computing  

NASA Astrophysics Data System (ADS)

With the development of multi-core processors, virtualization, distributed storage, broadband Internet and automatic management, a new type of computing mode named cloud computing is produced. It distributes computation task on the resource pool which consists of massive computers, so the application systems can obtain the computing power, the storage space and software service according to its demand. It can concentrate all the computing resources and manage them automatically by the software without intervene. This makes application offers not to annoy for tedious details and more absorbed in his business. It will be advantageous to innovation and reduce cost. It's the ultimate goal of cloud computing to provide calculation, services and applications as a public facility for the public, So that people can use the computer resources just like using water, electricity, gas and telephone. Currently, the understanding of cloud computing is developing and changing constantly, cloud computing still has no unanimous definition. This paper describes three main service forms of cloud computing: SAAS, PAAS, IAAS, compared the definition of cloud computing which is given by Google, Amazon, IBM and other companies, summarized the basic characteristics of cloud computing, and emphasized on the key technologies such as data storage, data management, virtualization and programming model.

Zhang, Shufen; Yan, Hongcan; Chen, Xuebin

36

U of M Civil Service Wellness Survey: Finding Out Employees' Health and Wellness Needs. A Report of Key Findings.  

ERIC Educational Resources Information Center

Key findings from a wellness survey conducted with University of Minnesota civil service employees are discussed. The survey was designed to provide information to guide future campus health and wellness programming. Four topics were covered: physical fitness/exercise, nutrition, self-improvement/psychological health, and general health/preventive…

Matross, Ron; Roesler, Jon

37

Utilization of research findings: A matter of research tradition  

Microsoft Academic Search

Differences between the realist and pragmatist research traditions are seen to explain different levels of utilization of\\u000a research findings.\\u000a \\u000a The realist tradition, which views knowledge as a true representation of reality with the role of research being to reveal\\u000a its underlying causal relations, is less associated with high levels of utilization. In the pragmatist tradition, on the other\\u000a hand, knowledge

Ruth Zuzovsky

1994-01-01

38

Researcher Perspectives on Disclosure of Incidental Findings in Genetic Research  

PubMed Central

Genetic research can produce information that is beyond the aims of the research study yet may be of clinical or personal interest to study participants. We conducted semi-structured interviews with 44 researchers who were asked to describe how they would respond to a hypothetical vignette regarding the disclosure of findings with unanticipated clinical significance to research study participants. Interviews were transcribed and analyzed using content and thematic analyses. Researchers’ decision-making processes about whether to disclose incidental findings were governed by potentially conflicting duties in three primary domains: information quality, adherence to rules, and participant welfare. There are several actions researchers can take to prepare for incidental findings, including: adding specific language in informed consent documents to state clearly how investigators will handle disclosure; exploring how prepared participants might be during the consent process to make decisions about how they would like to be approached in the event of incidental findings; developing procedures for appropriately communicating individual results and providing follow-up support based on participant preferences; and, in genetic research, having an awareness of the range of traits expressed by the genes under study. PMID:20831419

Meacham, Meredith C.; Starks, Helene; Burke, Wylie; Edwards, Kelly

2012-01-01

39

Researchers Find Japanese Submarine at Pearl Harbor  

NSDL National Science Digital Library

Earlier this week, researchers from the University of Hawaii and the Hawaii Underwater Research Lab located the remains of a Japanese midget submarine. Found in 1200 feet of water, the submarine was sunk by the USS Ward just an hour before the aerial attack on Pearl Harbor on December 7, 1941. Most important, the discovery of the midget submarine offers concrete physical evidence that the United States did fire the first shot against the Japanese. Previous expeditions to locate the sub, including an effort made in 2000 by the National Geographic Society, had been unsuccessful, largely due to the fact that the area is a military "junkyard" with tons of debris on the ocean floor.For more in-depth information on this story, readers may find the first four news links particularly helpful. The fifth link leads to the Hawaii Underwater Research Lab's Web site that features photographs of the midget sub from the expedition earlier this week. The sixth link is to a Web site dealing with the history and missions of the USS Ward. The final link contains detailed information about the 2000 expedition led by Robert Ballard, with support from the National Geographic Society, to find the midget submarine.

Green, Marcia.

2002-01-01

40

Approaches for Communicating Key Sources of Uncertainty While Reinforcing Core Climate Science Findings  

NASA Astrophysics Data System (ADS)

Projections of regional-scale climate change have high importance for policymakers, climate-sensitive industries and communities and need to be conveyed in a way that makes key uncertainties clear to non-technical audiences. Uncertainties in climate change projections arise from three primary sources: natural climate fluctuations that over relatively short time scales can amplify or moderate trends resulting from anthropogenic climate change; uncertainties in the climate system's response to a given level of radiative forcing, which is reflected in the range of responses incorporated into global climate model simulations; and uncertainties in future emissions by society, and thus the scale of future radiative forcing. The relative importance of these sources varies across regions, climate indicators and forecast lead times. Public understanding and informed public policy will be well-served by a greater emphasis in future research publications and climate assessments on distinguishing among these sources of uncertainty across regions, climate indicators and forecast lead times. We focus in particular on recommendations to improve the ways in which assessments characterize and communicate key policy-relevant sources of uncertainty in projections of climate change while reinforcing core climate science findings in public-facing documents.

Frumhoff, P. C.; Ekwurzel, B.; McCarthy, J. J.

2011-12-01

41

Clinical Trials: A Crucial Key to Human Health Research  

MedlinePLUS

... Past Issues Clinical Trials: A Crucial Key to Human Health Research Past Issues / Summer 2006 Table of ... Institutes of Health (NIH), which anyone with a computer and Web browser can tap into for a ...

42

The return of individual research findings in paediatric genetic research.  

PubMed

The combination of the issue of return of individual genetic results/incidental findings and paediatric biobanks is not much discussed in ethical literature. The traditional arguments pro and con return of such findings focus on principles such as respect for persons, autonomy and solidarity. Two dimensions have been distilled from the discussion on return of individual results in a genetic research context: the respect for a participant's autonomy and the duty of the researcher. Concepts such as autonomy and solidarity do not fit easily in the discussion when paediatric biobanks are concerned. Although parents may be allowed to enrol children in minimal risk genetic research on stored tissue samples, they should not be given the option to opt out of receiving important health information. Also, children have a right to an open future: parents do not have the right to access any genetic data that a biobank holds on their children. In this respect, the guidelines on genetic testing of minors are applicable. With regard to the duty of the researcher the question of whether researchers have a more stringent duty to return important health information when their research subjects are children is more difficult to answer. A researcher's primary duty is to perform useful research, a policy to return individual results must not hamper this task. The fact that vulnerable children are concerned, is an additional factor that should be considered when a policy of returning results is laid down for a specific collection or research project. PMID:21059631

Hens, Kristien; Nys, Herman; Cassiman, Jean-Jacques; Dierickx, Kris

2011-03-01

43

76 FR 68460 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013

...awards and by NIH intramural research funds from the National...Dental and Craniofacial Research (NIDCR). ORI found that the Respondent engaged in research misconduct by including...T32 CA09677, Radiation Biology Training Grant,''...

2011-11-04

44

A Short Review of School Field Trips: Key Findings from the Past and Implications for the Future  

Microsoft Academic Search

This review of the literature on field trips to out-of-school settings will briefly summarize key findings and discuss implications for future research and field trip practice. Cognitive and affective learning can occur as a result of class visits to out-of-school settings, and learning outcomes are fundamentally influenced by the structure of the field trip, setting novelty, prior knowledge and interest

Jennifer DeWitt; Martin Storksdieck

2008-01-01

45

Language Learning at Key Stage 2: Findings from a Longitudinal Study  

ERIC Educational Resources Information Center

This paper discusses some of the findings from a 3-year longitudinal study of language learning in the upper stage of English primary schools, i.e. at Key Stage 2. This largely qualitative study (commissioned by the then Department for Children, Schools and Families) was designed to explore and document developing provision and practice in a…

Cable, Carrie; Driscoll, Patricia; Mitchell, Rosamond; Sing, Sue; Cremin, Teresa; Earl, Justine; Eyres, Ian; Holmes, Bernardette; Martin, Cynthia; Heins, Barbara

2012-01-01

46

Teaching Teachers for the Future (TTF) Project TPACK Survey: Summary of the Key Findings  

ERIC Educational Resources Information Center

This paper presents a summary of the key findings of the TTF TPACK Survey developed and administered for the Teaching the Teachers for the Future (TTF) Project implemented in 2011. The TTF Project, funded by an Australian Government ICT Innovation Fund grant, involved all 39 Australian Higher Education Institutions which provide initial teacher…

Finger, Glenn; Jamieson-Proctor, Romina; Cavanagh, Rob; Albion, Peter; Grimbeek, Peter; Bond, Trevor; Fitzgerald, Robert; Romeo, Geoff; Lloyd, Margaret

2013-01-01

47

Animal Research: Finding Cures, Saving Lives  

NSDL National Science Digital Library

This website provides an online and a printable brochure that provides information on why researchers study animals, how research animals are cared for, the ethics of animal research, cosmetic testing on animals, and how animal research helps people in the context of a diabetes patient.

2010-06-24

48

Ecological Validity and Impact: Key Challenges for Music Education Research  

Microsoft Academic Search

\\u000a In order to simultaneously refine and broaden the research and theoretical bases for music education, as well as ensuring\\u000a their practical relevance, I believe that we have to address two key challenges: ecological validity and impact. These are\\u000a in a symbiotic relationship. If our research is to have professional impact, it has to be ecologically valid; if it has such

Graham F. Welch

49

76 FR 61361 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013

...research misconduct by (1) plagiarizing text and falsifying data from two publications...significant portions of that plagiarized text in two grant applications to the National...in research misconduct by plagiarizing text, falsifying data and references,...

2011-10-04

50

78 FR 67363 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013

...WU) and ORI's subsequent oversight analysis, ORI found that Dr. Hao Wang, former Associate Professor of Surgery and Pathology, Schulich School of Medicine and Dentistry, WU, engaged in research misconduct in research supported by National...

2013-11-12

51

Translating research findings into health policy  

Microsoft Academic Search

Evidence of the influence of research on health policy is paradoxical. While there is scant evidence that research has had any impact on the direction or implementation of widespread health reforms, research on evidence-based medicine has dramatically increased, despite limited evidence that it has affected clinical practice. These developments have occurred in the context of a general decline in state

Peter Davis; Philippa Howden-Chapman

1996-01-01

52

Drugs and sport. Research findings and limitations.  

PubMed

Many types of drugs are used by athletes to improve performance. This paper reviews the literature on 3 categories of drugs: those that enhance performance as stimulants (amphetamines, ephedrine, and cocaine), those that are used to reduce tremor and heart rate (beta-blockers) and those involved in bodyweight gain or loss (anabolic-androgenic steroids, growth hormone, beta 2-agonists, and diuretics). Limitations of research on these drugs as they relate to performance enhancement are also discussed. The numerous studies that have assessed the effects of amphetamines on performance report equivocal results. This may be due to the large interindividual variability in the response to the drug and the small sample sizes used. Most studies, however, show that some individuals do improve exercise performance when taking amphetamines, which may be attributed to their role in masking fatigue. As a stimulant, ephedrine has not been found to improve performance in the few studies available. More recently, ephedrine has been purported to be effective as a fat burner and used by athletes to maintain or improve muscle mass. Although research on individuals with obesity supports the use of ephedrine for fat loss, no studies have been done on athletes. The few studies of cocaine and exercise suggest that little to no performance gains are incurred from cocaine use. Moreover, the sense of euphoria may provide the illusion of better performance when, in actuality, performance was not improved or was impaired. beta-Blockers have been found to reduce heart rate and tremor and to improve performance in sports that are not physiologically challenging but require accuracy (e.g. pistol shooting). However, there is evidence that some individuals may be high responders to beta-blockers to the extent that their heart rate response is so blunted as to impair performance. Although equivocal, several studies have reported that anabolic-androgenic steroids increase muscle size and strength. However, most studies are not well controlled and use insufficient drug doses. One recent well controlled study did find an increase in muscle mass and strength with supraphysiological doses, and the improvements were greater in participants who were also resistance training. There is little information available on the effects of growth hormone on muscle mass or performance in athletes, although data suggest that growth hormone administration does not increase muscle protein synthesis. beta 2-Agonists, such as clenbuterol and salbutamol, when administered orally appear to improve muscular strength due to their potential role in increasing muscle mass. However, studies have not been done using athletes. Diuretics results in a loss of body water and hence bodyweight that can be advantageous for sports with strict bodyweight classifications. There is insufficient evidence on possible performance decrements in the field that could result from dehydration induced by the diuretics. Overall, the most significant concern in studies of drug use is the large inter-individual variability in responses to a drug. Further studies are needed to understand why some individuals are more responsive than others and to assess whether the responses are consistent for a given individual. Most studies of drug effectiveness have not used athletes. The effectiveness of many drugs may be reduced in highly trained athletes because there is a lower margin for improvement. PMID:9421862

Clarkson, P M; Thompson, H S

1997-12-01

53

Criticisms of educational research: key topics and levels of analysis  

Microsoft Academic Search

The article is an exploration of the meanings and worthiness of criticism as a significant phenomenon in the evolution of educational research during the 1990s. While drawing on an overview of the vast amount of documents expressing criticisms of educational research in the UK, western and eastern continental Europe and the USA, it summarises the findings of a study based

Alis Oancea

2005-01-01

54

77 FR 46438 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013

...investigation conducted by the John Wayne Cancer Institute (JWCI) and additional...in research supported by National Cancer Institute (NCI), National Institutes...gangliosides in patients with confined prostate cancer.'' Int. J. Cancer...

2012-08-03

55

78 FR 14797 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF HEALTH AND HUMAN SERVICES Office...doctoral student, Department of Psychology, WUSTL, engaged in research...National Institute of Mental Health (NIMH), National Institutes of Health (NIH), grant R56...

2013-03-07

56

78 FR 72892 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013

...research supported by National Cancer Institute (NCI), National...Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI. ORI found that the Respondent...supported data in Table 1 included in Cancer Epidemiol Biomarkers Prev...

2013-12-04

57

Animal Research: Finding Cures, Saving Lives  

NSDL National Science Digital Library

The U.S. Public Health Service acknowledges that "virtually every medical achievement of the last century has depended directly or indirectly on research with animals." Created by the American Physiological Society, this website helps students learn about and explore the ethics and particulars of animal research. It answers common questions in a straight-forward and accessible manner. It also includes links to other resources to aid in a deeper exploration of the subject.

Society, The A.

58

A Method to Find Learner's Key Characteristic in Wed-Based Learning  

Microsoft Academic Search

One of the challenges in personalized e-learning research field is how to meet the unique learning strategies according to\\u000a a learner’s personality characteristic. But a learner’s characteristic may have many attributes, and some of them have not\\u000a equal value for personalized e-learning. This paper exploits the aspect to evaluate the important attributes, puts forward\\u000a the concept of key personality characteristic

Xiyuan Wu; Qinghua Zheng; Haifei Li; Guangdong Liu

2008-01-01

59

Training: Who Needs It? Research Report 1995. Key Issues for Providers.  

ERIC Educational Resources Information Center

Aimed at all those involved in the supply of training and vocational education for the hospitality industry, this report summarizes findings of the research report, "Training Who Needs It?" It draws out and explores in more detail key issues relating to the provision of training, support, and related initiatives for the industry. Section 1…

Hotel and Catering Training Co., London (England).

60

76 FR 63621 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013

...desirous of concluding this matter without further expenditure...Settlement Agreement to resolve this matter. This settlement is not an...and ORI agreed to settle this matter as follows: (1) Respondent...application for PHS support for a research project on which her...

2011-10-13

61

76 FR 23599 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013

...blot experiments and switched the labels on four (4) cell culture dishes for cells used in the same type of experiments to cause...research materials by adding ethanol to his colleague's cell culture media, with the deliberate intent to effectuate the...

2011-04-27

62

Researching Women's Groups Findings, Limitations, and Recommendations  

ERIC Educational Resources Information Center

There is not a "typical" women's group, nor are there "typical" women's issues. Every women's group is diverse, with as many viewpoints and perspectives as there are members in the group. Using the group format for women is common practice with many counselors. It is interesting that there has been little empirical research reported on women's…

Leech, Nancy L.; Kees, Nathalie L.

2005-01-01

63

Human lead exposure: Some recent research findings  

SciTech Connect

One of the practical problems facing industrial hygienists and safety managers in the lead industry is finding new ways to limit or reduce lead intake in order to protect workers from the deleterious effects of this metal. Exposure to lead generally takes place by inhalation of airborne particles and by ingestion. Airborne exposure is comparatively well understood and methods for the control of airborne lead have been developed and put into place in industrial facilities. Both for the general public and for workers, however, it is thought that a significant fraction of the total lead intake occurs by ingestion as opposed to inhalation. Furthermore, factors such as personal hygiene, hand washing, diet, cigarette smoking, alcohol consumption, use of medications, bone injury, existing disease, and others may also have positive or negative effects on lead absorption and blood lead levels. How these variables actually operate in practice for lead-exposed workers is unfortunately not very well understood. As scientific and medical knowledge increases, progress has been made in the understanding of some of the factors affecting blood lead levels. In this article, the author summarizes the findings of a few interesting recent reports that point the way toward future progress in this area.

Saryan, L.A.

1999-09-01

64

Step I: Find Your InterestStep I: Find Your InterestStep I: Find Your InterestStep I: Find Your Interest A Research Opportunity Fair is  

E-print Network

interest through your current biology courses and pro- fessors. · Reading scientific journals may alsoStep I: Find Your InterestStep I: Find Your InterestStep I: Find Your InterestStep I: Find Your Interest · A Research Opportunity Fair is usually held each year in April. All current research

Kelly, John J.

65

Television Advertising and Children: Issues, Research and Findings.  

ERIC Educational Resources Information Center

This volume consists of 10 papers dealing with issues, research and research findings regarding the effects of television advertising on children. The first paper critically examines recent research literature which bears on policy questions related to the effects of television advertising on children. Findings from a study designed to examine…

Esserman, June F., Ed.

66

Teacher and Principal Value-Added: Research Findings and Implementation Practices. Final Report  

ERIC Educational Resources Information Center

This report summarizes research findings and implementation practices for teacher and principal value-added models (VAMs), as a first step in the Team Pennsylvania Foundation's (Team PA) pilot project to inform the development of a full, statewide model evaluation system. We have selected 21 studies that represent key issues and findings in the…

Lipscomb, Stephen; Teh, Bing-ru; Gill, Brian; Chiang, Hanley; Owens, Antoniya

2010-01-01

67

Current Research Findings on End-of-Life Decision Making among Racially or Ethnically Diverse Groups  

ERIC Educational Resources Information Center

Purpose: We reviewed the research literature on racial or ethnic diversity and end-of-life decision making in order to identify key findings and provide recommendations for future research. Design and Methods: We identified 33 empirical studies in which race or ethnicity was investigated as either a variable predicting treatment preferences or…

Kwak, Jung; Haley, William E.

2005-01-01

68

'Project launch': from research finding to therapeutic product.  

PubMed

Only 0.1-0.5% of new therapy candidates gains marketing approval; just 10-20% of the approved ones ultimately recoup the ~0.6-0.9$USbn invested into their R&D until marketing authorisation. One reason is the high inherent risk of new therapeutic products development. Further reasons are suboptimal decisions during R&D and, too often, lack of adequate experience. To bridge the latter gap, this article succinctly reviews identification of new product opportunities and their patent protection, the resulting commercial opportunity and portfolio valuation, planning and conduct of the ensuing preclinical and clinical tests, as well as therapeutic product registration and price reimbursement, covering risk management as an aside. The article also clarifies the key terms, identifies the main pit falls, highlights the essential requirements for and the goals of different product development steps, to facilitate communication between researchers and developers. By combining public information with personal experience and recommendations the article aims at informing more broadly those who are familiar mainly with some of the (strictly regulated) activities involved in design, development and launch of new therapeutic products, be it that they are medicinal products or medical devices. Taken together, this should support initiation and evolution of new therapeutic products and assist researchers in finding-and better and more smoothly co-operating with-consultants or partners in development and marketing. PMID:23948554

Cevc, Gregor

2014-01-23

69

Key Ethical Issues in Pediatric Research: Islamic Perspective, Iranian Experience  

PubMed Central

Objective The importance of pediatric research especially in the ethically proven trials resulted in considerable legislative attempts in association with compiling ethical guidelines. Because of children's vulnerability conducting pediatric research raises different ethical issues; the two most important of which are informed consent and risk-benefit assessment. Differences in religious and socio-cultural context limit implication of ethical standards. Methods At the aim of finding a solution we critically reviewed guidelines, and literatures as well as Islamic points in addition to comparing different viewpoints in application of ethical standards in pediatric research. Findings The literature review showed that pediatric research guidelines and authors’ viewpoints have the same basic ethical core, but there are some variations; depend on cultural, religious, and social differences. Furthermore, these standards have some limitations in defining informed consent according to child's age and capacity upon application. Conclusion In this regard Islamic approach and definition about growth development and puberty sheds light and clarifies a clearer and more rational address to the issue. PMID:23429172

Mobasher, Mina; Salari, Pooneh; Larijani, Bagher

2012-01-01

70

The application of qualitative research findings to oncology nursing practice.  

PubMed

The Oncology Nursing Society (ONS) has established an ambitious research agenda and professional priorities based on a survey by LoBiondo-Wood et al. (2014). With the overall goal to "improve cancer care and the lives of individuals with cancer" (Moore & Badger, 2014, p. 93) through research activities, translating those research findings to direct clinical practice can be overwhelming. As clinicians, understanding how to critique research for quality prior to incorporating research findings into practice is important. The ultimate goal in this critique is to ensure that decisions made about patient care are based on strong evidence. However, the process for appraisal of qualitative research can be ambiguous and often contradictory as a result of the elusive aspect of quality in qualitative research methods (Seale, 1999). In addition, with more than 100 tools available to evaluate qualitative research studies (Higgins & Green, 2011), a lack of consensus exists on how to critically appraise research findings. PMID:25355024

Cuthbert, Colleen Ann; Moules, Nancy

2014-11-01

71

Prisons Research Centre Annual Report on Research Findings 2010  

E-print Network

, Susie Hulley and Clare McLean This research had two main components: an interview, survey in the two sectors; and to provide an analysis of motivations, orientations and attitudes among senior, organisation and consistency, and personal development. The emphasis in staff training on interpersonal skills

Travis, Adrian

72

Knowledge Mining: A Quantitative Synthesis of Research Results and Findings  

Microsoft Academic Search

Knowledge mining emerged as a rapidly growing interdisciplinary field that merges together databases, statistics, machine\\u000a learning and related areas in order to extract valuable information and knowledge in large volumes of data. In this paper\\u000a we present the key finding of the results achieved during the NEMIS Conference on “Knowledge Mining”.

Penelope Markellou; Maria Rigou; Spiros Sirmakessis

73

40 CFR 63.1176 - Where can I find definitions of key words used in this subpart?  

Code of Federal Regulations, 2013 CFR

...HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Mineral Wool Production § 63.1176 Where can I find definitions of key words used in this subpart? The definitions of...

2013-07-01

74

40 CFR 63.1176 - Where can I find definitions of key words used in this subpart?  

...HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Mineral Wool Production § 63.1176 Where can I find definitions of key words used in this subpart? The definitions of...

2014-07-01

75

40 CFR 63.1176 - Where can I find definitions of key words used in this subpart?  

Code of Federal Regulations, 2011 CFR

...HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Mineral Wool Production § 63.1176 Where can I find definitions of key words used in this subpart? The definitions of...

2011-07-01

76

Researchers Find Gene Mutation That May Protect Against Heart Disease  

MedlinePLUS

... Researchers Find Gene Mutation That May Protect Against Heart Disease Rare genetic variation appears to cut the risk ... 2014 Related MedlinePlus Pages Genes and Gene Therapy Heart Diseases WEDNESDAY, Nov. 12, 2014 (HealthDay News) -- Mutations that ...

77

Multiple Perpetrator Rape: Naming an Offence and Initial Research Findings  

ERIC Educational Resources Information Center

Multiple perpetrator rape presents a significant problem nationally and internationally. However, previous research is limited and findings are often contradictory. The details of 101 rape allegations recorded in a six-month period in a large police force in England were analysed. Findings are presented about case classification, victim and…

Horvath, Miranda Angel Helena; Kelly, Liz

2009-01-01

78

I.5 Key Focus Group Findings on I-131 Exposure from the Nevada Test Site: Preliminary Findings from  

E-print Network

-6 A. Lower-Exposure Public I-5-7 B. Higher-Exposure Public I-5-11 C. Primary Care Physicians I-5-14 IV-exposure public, and primary care physicians. Primary objectives of this research were: · To gauge participants

79

A system for addressing incidental findings in neuroimaging research.  

PubMed

When healthy subjects undergo brain imaging, incidental findings are not rare. The optimal response to such findings has been the focus of considerable discussion. The current report describes the operations and results of a system that provides a review of incidental findings by an appropriate medical professional. A web-based system was created whereby investigators performing brain MRI scans on healthy subjects could refer images with suspected concerns to a board certified radiologist who had a Certificate of Added Qualification in Neuroradiology. The specific details of this system are described. Among 27 scans suspected by an investigator of having a significant finding, all but one were referred by a researcher with a PhD. The most common concerns described by these investigators were for the possible presence of a cyst or of enlarged ventricles. The most common findings reported by the radiologist were Virchow-Robin spaces and cysts. Findings were generally of low clinical significance, with 1 major exception. Identifying the optimal response to incidental findings in neuroimaging research remains a challenge. The current report describes a system for providing expert assistance and so addresses these issues in the setting of suspected incidental findings. To our knowledge the current system is the first to provide a specific means for evaluation of incidental findings in neuroimaging research. PMID:21224007

Cramer, Steven C; Wu, Jennifer; Hanson, Joseph A; Nouri, Sarvenaz; Karnani, Diraj; Chuang, Tony M; Le, Vu

2011-04-01

80

A System for Addressing Incidental Findings in Neuroimaging Research  

PubMed Central

When healthy subjects undergo brain imaging, incidental findings are not rare. The optimal response to such findings has been the focus of considerable discussion. The current report describes the operations and results of a system that provides review of incidental findings by an appropriate medical professional. A web-based system was created whereby investigators performing brain MRI scans on healthy subjects could refer images with suspected concerns to a board certified radiologist who had a Certificate of Added Qualification in Neuroradiology. The specific details of this system are described. Among 27 scans suspected by an investigator of having a significant finding, all but one were referred by a researcher with a PhD. The most common concerns described by these investigators were for the possible presence of a cyst or of enlarged ventricles. The most common findings reported by the radiologist were Virchow-Robin spaces and cysts. Findings were generally of low clinical significance, with 1 major exception. Identifying the optimal response to incidental findings in neuroimaging research remains a challenge. The current report describes a system for providing expert assistance and so addresses these issues in the setting of suspected incidental findings. To our knowledge the current system is the first to provide a specific means for evaluation of incidental findings in neuroimaging research. PMID:21224007

Cramer, Steven C.; Wu, Jennifer; Hanson, Joseph A.; Nouri, Sarvenaz; Karnani, Diraj; Chuang, Tony M.; Le, Vu

2011-01-01

81

Genetically Informative Research on Adolescent Substance Use: Methods, Findings, and Challenges  

ERIC Educational Resources Information Center

Objective: To provide an overview of the genetic epidemiology of substance use and misuse in adolescents. Method: A selective review of genetically informative research strategies, their limitations, and key findings examining issues related to the heritability of substance use and substance use disorders in children and adolescents is presented.…

Lynskey, Michael T.; Agrawal, Arpana; Heath, Andrew C.

2010-01-01

82

Case Western researchers present new findings for glioblastoma  

Cancer.gov

Physician-scientists from University Hospitals (UH), Case Medical Center's Seidman Cancer Center and Case Western Reserve University School of Medicine presented new research findings this week at the Annual Meeting of the American Association for Cancer Research (AACR) in Chicago. One study sought to identify protein biomarkers that can help physicians determine which patients may benefit from standard treatment for GBM.

83

Stem Cell Research and Applications: Findings and Recommendations  

NSDL National Science Digital Library

These resources are findings and recommendations to stem cell research and applications. Human stem cell research holds enormous potential for contributing to our understanding of fundamental human biology. Although it is not possible to predict the outcomes from basic research, such studies will offer the real possibility for treatments and ultimately for cures for many diseases for which adequate therapies do not exist. This resource is provided by AAAS and ICS.

;

1999-11-01

84

IPCC Climate Change 2013: Mitigation of Climate Change - Key Findings and Lessons Learned  

NASA Astrophysics Data System (ADS)

The Working Group III contribution to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change, Mitigation of Climate Change, examines the results of scientific research about mitigation, with special attention on how knowledge has evolved since the Fourth Assessment Report published in 2007. Throughout, the focus is on the implications of its findings for policy, without being prescriptive about the particular policies that governments and other important participants in the policy process should adopt. The report begins with a framing of important concepts and methods that help to contextualize the findings presented throughout the assessment. The valuation of risks and uncertainties, ethical concepts and the context of sustainable development and equity are among the guiding principles for the assessment of mitigation strategies. The report highlights past trends in stocks and flows of greenhouse gases and the factors that drive emissions at global, regional, and sectoral scales including economic growth, technology or population changes. It provides analyses of the technological, economic and institutional requirements of long-term mitigation scenarios and details on mitigation measures and policies that are applied in different economic sectors and human settlements. It then discusses interactions of mitigation policies and different policy instrument types at national, regional and global governance levels and between economic sectors, The Working Group III report comprises 16 chapters and in assembling this assessment authors were guided by the principles of the IPCC mandate: to be explicit about mitigation options, to be explicit about their costs and about their risks and opportunities vis-à-vis other development priorities, and to be explicit about the underlying criteria, concepts, and methods for evaluating alternative policies.

Sokona, Youba

2014-05-01

85

Who are the key players in a new translational research network?  

PubMed Central

Background Professional networks are used increasingly in health care to bring together members from different sites and professions to work collaboratively. Key players within these networks are known to affect network function through their central or brokerage position and are therefore of interest to those who seek to optimise network efficiency. However, their identity may not be apparent. This study using social network analysis to ask: (1) Who are the key players of a new translational research network (TRN)? (2) Do they have characteristics in common? (3) Are they recognisable as powerful, influential or well connected individuals? Methods TRN members were asked to complete an on-line, whole network survey which collected demographic information expected to be associated with key player roles, and social network questions about collaboration in current TRN projects. Three questions asked who they perceived as powerful, influential and well connected. Indegree and betweenness centrality values were used to determine key player status in the actual and perceived networks and tested for association with demographic and descriptive variables using chi square analyses. Results Response rate for the online survey was 76.4% (52/68). The TRN director and manager were identified as key players along with six other members. Only two of nine variables were associated with actual key player status; none with perceived. The main finding was the mismatch between actual and perceived brokers. Members correctly identified two of the three central actors (the two mandated key roles director and manager) but there were only three correctly identified actual brokers among the 19 perceived brokers. Possible reasons for the mismatch include overlapping structures and weak knowledge of members. Conclusions The importance of correctly identifying these key players is discussed in terms of network interventions to improve efficiency. PMID:23987790

2013-01-01

86

Finding Fault? Exploring Legal Duties to Return Incidental Findings in Genomic Research  

PubMed Central

The use of whole-genome sequencing in biomedical research is expected to produce dramatic advances in human health. The increasing use of this powerful, data-rich new technology in research, however, will inevitably give rise to incidental findings (IFs)—findings with individual health or reproductive significance that are beyond the aims of the particular research—and the related questions of whether and to what extent researchers have an ethical obligation to return IFs. Many have concluded that researchers have an ethical obligation to return some findings in some circumstances but have provided vague or context-dependent approaches to determining which IFs must be returned and when. As a result, researchers have started returning IFs inconsistently, giving rise to concerns about legal liability in circumstances in which notification could have potentially prevented injury. Although it is clear that ethical guidance should not be automatically codified as law and that crafting ethical obligations around legal duties can be inappropriate, the ethical debate should not proceed unaware of the potential legal ramifications of advancing and implementing an ethical obligation to return IFs. This Article assesses the legal claims that could be brought for a researcher’s failure to return IFs. The potential for researchers to be held liable in tort is still uncertain and turns largely on a number of factors—including customary practice and guidance documents—that are still in flux. Unlike medical care, which has a well-defined duty into which evolving scientific knowledge about genetics and genomics can readily be incorporated, a researcher’s duty to return IFs is less well defined, making it difficult to determine at the outset whether and when legal liability will attach. This Article advocates for a clearer, ethically sound standard of requiring that researchers disclose in the informed consent document which approach to offering IFs will be taken. This approach enables participants to know at the outset which findings, if any, will be returned, allows researchers to ascertain when their failure to appropriately return incidental findings will give rise to liability, and enables courts to make determinations that will produce more consistent legal guidance.

Pike, Elizabeth R.; Rothenberg, Karen H.; Berkman, Benjamin E.

2014-01-01

87

Recruiting Underserved Mothers to Medical Research: Findings from North Carolina  

PubMed Central

Representative samples are required for ethical, valid, and useful health research. Yet, recruiting participants, especially from historically underserved communities, can be challenging. This paper presents findings from in-depth interviews with 40 mothers about factors that might influence their willingness to participate or allow their children to participate in medical research. Saliency analysis organizes the findings. Frequent and important salient themes about research participation included concerns that it might cause participants harm, hope that participants might gain a health benefit, and recognition that time and transportation resources could limit participation. Ultimately, we propose that a theoretical model, such as the Theory of Planned Behavior (TPB), will facilitate more systematic evaluation of effective methods for recruitment and retention of participants in medical research. Future research should explore the utility of such a model for development of effective recruitment and retention strategies. PMID:24185171

Spears, Chaya R.; Sandberg, Joanne C.; O'Neill, Jenna L.; Grzywacz, Joseph G.; Howard, Timothy D.; Feldman, Steven R.; Arcury, Thomas A.

2014-01-01

88

Recruiting underserved mothers to medical research: findings from North Carolina.  

PubMed

Representative samples are required for ethical, valid, and useful health research. Yet, recruiting participants, especially from historically underserved communities, can be challenging. This paper presents findings from in-depth interviews with 40 mothers about factors that might influence their willingness to participate or allow their children to participate in medical research. Saliency analysis organizes the findings. Frequent and important salient themes about research participation included concerns that it might cause participants harm, hope that participants might gain a health benefit, and recognition that time and transportation resources could limit participation. Ultimately, we propose that a theoretical model, such as the Theory of Planned Behavior (TPB), will facilitate more systematic evaluation of effective methods for recruitment and retention of participants in medical research. Future research should explore the utility of such a model for development of effective recruitment and retention strategies. PMID:24185171

Spears, Chaya R; Sandberg, Joanne C; O'Neill, Jenna L; Grzywacz, Joseph G; Howard, Timothy D; Feldman, Steven R; Arcury, Thomas A

2013-11-01

89

Where do UK health services researchers publish their findings?  

PubMed Central

Health services research has emerged as the third vital requirement for understanding and improving health care, alongside basic science and clinical research. This has coincided with more stringent management of research, in particular by funding bodies. The latter are seeking to use bibliographic databases to aid the monitoring of the output of their investments. The principal source of data in the UK is the Research Outputs Database (ROD) set up by the Wellcome Trust primarily to monitor basic and clinical research. Health services researchers' output is difficult to monitor in view of the large number and wide variety of journals in which they publish. In addition, nearly half the journals (representing 35% of the articles) are not currently covered by the ROD. Funding bodies will underestimate the quantity of health services researchers' output unless they take these findings into account. PMID:10396256

Black, N; Davies, S C

1999-01-01

90

Findings  

NSDL National Science Digital Library

Starting in February 2001, the National Institute of General Medical Sciences (NIGMS) began publishing "Findings" magazine. The publication features research and findings from scholars doing work with funding from the NIGMS. Visitors can browse the archive of the publication by topic or date, and they can also check out the sample articles from the latest edition on the homepage. Recent pieces have included "Drugs from Deep Down", "Mesmerized by Metals", and "Just Found", which talks about potential sunburn treatments. The site also has the "Find More" area, which contains an image gallery, school resources, free slide kits, and interactive games. Also, the "Watch" area contains interviews with scientists like Dr. Kevin Tracey talking about his investigations into sepsis. Finally, visitors can also sign up to receive Findings via email.

91

Becoming a Scientist: Research Findings on STEM Students' Gains from Conducting Undergraduate Research  

NASA Astrophysics Data System (ADS)

Undergraduate research is widely believed to enhance STEM students' education and increase their persistence to graduate education and careers in the sciences. Yet until very recently, little evidence from research and evaluation studies was available to substantiate such claims and document what students gain from doing undergraduate research or how these gains come about. We have conducted a three-year qualitative research study of STEM students participating in UR at four liberal arts colleges with a strong tradition of faculty-led summer research apprenticeships. Benefits to students reported by both students and their faculty advisors are categorized into six main categories of gains in skills, knowledge, "thinking like a scientist," career preparation, career development, and personal and professional growth. Student and faculty observations are strongly corroborative, but also differ in interesting ways that reflect the distinct perspectives of each group: students are still in the midst of discovering their own career paths while faculty advisors have observed the later career development of their past research students. While not all students find UR to heighten their interest in graduate school, they do find it a powerful growth experience that clarifies their career ambitions by providing a "real world" experience of science. For students whose interest in science is reinforced, UR has a significant role in their professional socialization into the culture and norms of science, which we call "becoming a scientist," through interactions that draw them into the scientific community and experiences that deepen their understanding of the nature of research. Cumulatively, the qualitative data set of nearly 350 interviews offers a rich portrayal of the UR enterprise from a variety of perspectives. Longitudinal data enable us to track the influence of UR on students' career and education trajectories in the years after college, and comparative data from a group of students who did not undertake UR or pursued alternate experiences reveal the extent to which some benefits of UR may be derived from other experiences. Faculty interviews reveal the costs and benefits to faculty of participating in this intensive form of science education. The presentation will highlight key findings and emphasize their relevance to faculty and program directors undertaking UR or seeking to generate its benefits through other activities.

Hunter, A.; Laursen, S.; Thiry, H.; Seymour, E.

2006-12-01

92

Medical practice employee selection: application of recent research findings.  

PubMed

Findings based on recent research are presented to support the universal use of tests measuring general mental ability (GMA) and the Big Five personality factor of conscientiousness to evaluate applicants for all medical practice and health care system clerical, nursing, and office management positions. Widely validated measures of both of these factors are identified. These findings simplify the process of identifying employment methods for jobs in medical practices. This research also suggests that for some jobs, Work Samples, Structured Interviews, or other Big Five personality factors may add some incremental validity to the GMA + Conscientiousness combination. This should be determined based on job analysis. PMID:12661485

Solomon, Robert J

2003-01-01

93

Key Lessons about Induction for Policy Makers and Researchers  

ERIC Educational Resources Information Center

The purpose of this chapter is to digest the core chapters of this volume, which draws together some of the most sophisticated thinking on new teacher induction from the last decade. This chapter attends to five key understandings about induction programs, including their context, design, implementation, and outcomes. These understandings emerge…

Wayne, Andrew J.

2012-01-01

94

Organizational Social Network Research: Core Ideas and Key Debates  

Microsoft Academic Search

Given the growing popularity of the social network perspective across diverse organizational subject areas, this review examines the coherence of the research tradition (in terms of leading ideas from which the diversity of new research derives) and appraises current directions and controversies. The leading ideas at the heart of the organizational social network research program include: an emphasis on relations

Martin Kilduff; Daniel J. Brass

2010-01-01

95

Monitoring the Future: National Results on Adolescent Drug Use. Overview of Key Findings, 2006  

ERIC Educational Resources Information Center

This report provides a summary of drug use trends from a survey of nearly 50,000 eighth-, tenth-, and twelfth- grade students nationwide. It also includes perceived risk, personal disapproval, and perceived availability of each drug by this group. A synopsis of the methods used in the study and an overview of the key results from the 2006 survey…

Johnston, Lloyd D., O'Malley, Patrick M.; Bachman, Jerald G.; Schulenberg, John E.

2007-01-01

96

Disability travel in the United States: recent research and findings  

Microsoft Academic Search

The purpose of this paper is to report and compare the salient findings of recent research on travel by Americans with disabilities. Until 2002, when Open Doors Organization (ODO) sponsored its first nationwide study on travel by adults with disabilities (ODO 2002), conducted by Harris Interactive, there had never been a major, statistically reliable survey on the US disability travel

Laurel Van Horn

2007-01-01

97

September 17, 2010 LSUHSC research finds cause & remedy for learning &  

E-print Network

of medical marijuana LSUHSC research finds combo of plant nutrients kills breast cancer cells Chancellor a study that identified the cause of learning and memory deficits associated with medical marijuana use that inhibit COX-2 prevented these debilitating side effects. The results suggest the use of medical marijuana

98

Researcher finds some bees evolved to shout at competitors  

E-print Network

Researcher finds some bees evolved to shout at competitors July 7, 2014 Certain species of stingless bees in Brazil have been found to protect their sources of nectar and pollen from potential in other bee species. Dr. Elinor Lichtenberg from Washington State University made this discovery during

Nieh, James

99

Educational Financing in Developing Countries: Research Findings and Contemporary Issues.  

ERIC Educational Resources Information Center

This study focuses on contemporary issues of educational financing in developing countries and on available research findings as these relate, or can be related, to these issues. The first two chapters are analytical, examining common educational finance issues and testing the conventional wisdom of certain usual proposals. Chapter 1, "Issues in…

Schiefelbein, Ernesto

100

Summary of Findings and Recommendations Mountain Bongo Ecological Research  

E-print Network

processing remote-sensing imagery to create habitat-structure maps, which was the only practical way interventions based on these findings. The primary goal of this research was to understand bongo habitat, the Kenya Wildlife Service, and the Rhino Ark Charitable Trust. The aim of this report is to highlight our

101

Research on Key Technology and Applications for Internet of Things  

NASA Astrophysics Data System (ADS)

The Internet of Things (IOT) has been paid more and more attention by the academe, industry, and government all over the world. The concept of IOT and the architecture of IOT are discussed. The key technologies of IOT, including Radio Frequency Identification technology, Electronic Product Code technology, and ZigBee technology are analyzed. The framework of digital agriculture application based on IOT is proposed.

Chen, Xian-Yi; Jin, Zhi-Gang

102

Translating research findings on early experience to prevention: animal and human evidence on early attachment relationships.  

PubMed

Recent studies provide a wealth of findings on the mechanisms by which early stress exposure, particularly within the early child-parent attachment relationship, may influence long-term adaptation. Translating these findings to clinical practice and social policy is now underway. In this review, some key considerations in this translational task are examined, specifically, the conceptual bases underlying the research designs, the putative mechanisms involved, and the degree to which currently available findings might shape interventions. Although the primary focus is on depression, a broader range of phenotypes associated with poor early caregiving environments is also considered. PMID:17175412

O'Connor, Thomas G; Cameron, Judy L

2006-12-01

103

Finding and optimising the key factors for the multiple-response manufacturing process  

Microsoft Academic Search

With the advent of modern technology, manufacturing processes became so sophisticated that a single quality characteristic cannot reflect the true product quality. Thus, it is essential to perform the key factor analysis for the manufacturing process with multiple-input (factors) and multiple-output (responses). In this paper, an integrated approach of using the desirability function in conjunction with the Mahalanobis-Taguchi-Gram Schmit (MTGS)

Jeh-Nan Pan; Jianbiao Pan; Chun-Yi Lee

2009-01-01

104

Reflections of Girls in the Media: A Two-Part Study on Gender and Media. Summary of Key Findings.  

ERIC Educational Resources Information Center

This pamphlet summarizes the key findings of a two-part study that investigated the messages that young women (age 10 to 17) get from the media. A content analysis examined messages to girls across a range of media most heavily used by adolescent girls: television, movies, magazines, music videos, television commercials, and magazine…

1997

105

Monitoring the Future National Results on Adolescent Drug Use: Overview of Key Findings, 2011  

ERIC Educational Resources Information Center

Monitoring the Future (MTF) is a long-term study of American adolescents, college students, and adults through age 50. It has been conducted annually by the University of Michigan's Institute for Social Research since its inception in 1975 and is supported under a series of investigator-initiated, competing research grants from the National…

Johnston, Lloyd D.; O'Malley, Patrick M.; Bachman, Jerald G.; Schulenberg, John E.

2012-01-01

106

Authentic Research Immersion Experiences: the Key to Enduring Understandings  

NASA Astrophysics Data System (ADS)

Do authentic research experiences have a role in today's classrooms? Where do they fit into the constrained curriculum units and high-stakes testing regimen that define a teacher's world? It is possible, even in today's somewhat narrow teaching environment, to integrate authentic research into the classroom and evolve away from the worksheets and lessons that simply "teach to the test"? Authentic research immersion experiences must be carefully packaged the for classroom use with clear alignment to standards and a learning curve that is not too daunting. By helping teachers to see the value in replacing curricular units with authentic research experiences and designing the research program to fit within a teacher's needs, the rate of successful adoption of the research program becomes much higher. As a result, not only do their students reap the educational rewards of becoming active research participants in the process of science and learn it from the inside out, but the opportunity for the teachers to grow professionally in content and science process knowledge is also an additional benefit. NASA has had and continues to have a significant role in providing these data and mission- related immersion experiences for elementary classrooms through graduate school students.

Klug, S. L.

2007-12-01

107

Discovery and Disclosure of Incidental Findings in Neuroimaging Research  

PubMed Central

Purpose To examine different protocols for handling incidental findings on brain research MRIs, and provide a platform for establishing formal discussions of related ethical and policy issues. Materials and Methods Corresponding authors identified from a database of peer-reviewed publications in 1991–2002 involving functional MRI (fMRI), alone or in combination with other imaging modalities, were invited to participate in this web-based survey. The survey asked questions regarding knowledge and handling of incidental findings, as well as characteristics of the scanning environment, training required, IRB protocol requirements, and neuroradiologist involvement. Results Seventy-four investigators who conduct MRI studies in the United States and abroad responded. Eighty-two percent (54/66) reported discovering incidental findings in their studies, such as arteriovenous malformations, brain tumors, and developmental abnormalities. Substantial variability was found in the procedures for handling and communicating findings to subjects, neuroradiologist involvement, personnel permitted to operate equipment, and training. Conclusion Guidelines for minimum and optimum standards for detecting and communicating incidental findings on brain MRI research are needed. PMID:15503329

Illes, Judy; Kirschen, Matthew P.; Karetsky, Kim; Kelly, Megan; Saha, Arnold; Desmond, John E.; Raffin, Thomas A.; Glover, Gary H.; Atlas, Scott W.

2006-01-01

108

Researchers discover key mutation in acute myeloid leukemia;  

Cancer.gov

Researchers have discovered mutations in a particular gene that affects the treatment prognosis for some patients with acute myeloid leukemia (AML), an aggressive blood cancer that kills 9,000 Americans annually.

109

Writing implementation research grant proposals: ten key ingredients  

PubMed Central

Background All investigators seeking funding to conduct implementation research face the challenges of preparing a high-quality proposal and demonstrating their capacity to conduct the proposed study. Applicants need to demonstrate the progressive nature of their research agenda and their ability to build cumulatively upon the literature and their own preliminary studies. Because implementation science is an emerging field involving complex and multilevel processes, many investigators may not feel equipped to write competitive proposals, and this concern is pronounced among early stage implementation researchers. Discussion This article addresses the challenges of preparing grant applications that succeed in the emerging field of dissemination and implementation. We summarize ten ingredients that are important in implementation research grants. For each, we provide examples of how preliminary data, background literature, and narrative detail in the application can strengthen the application. Summary Every investigator struggles with the challenge of fitting into a page-limited application the research background, methodological detail, and information that can convey the project’s feasibility and likelihood of success. While no application can include a high level of detail about every ingredient, addressing the ten ingredients summarized in this article can help assure reviewers of the significance, feasibility, and impact of the proposed research. PMID:23062065

2012-01-01

110

Key findings from Year 2 of Full-Day Early Learning Kindergarten in Peel  

E-print Network

Kindergarten in Peel I'm playing with my friends at school (F-DAY EARLY LEARNING KINDERGARTEN IN PEEL REVIEW: PURPOSE OF THE RESEARCH services, specifically kindergarten, child care and parenting support in the Peel

Sokolowski, Marla

111

A Survey of American Voter Attitudes Concerning Child Care Services: Highlights and Key Findings.  

ERIC Educational Resources Information Center

A national telephone survey of a representative sample of 901 voters was conducted to measure voter attitudes toward child care and, in particular, the Act for Better Child Care Services (ABC). The survey also explored attitudes toward parental leave. Findings indicated that: (1) a majority of Americans think of child care as an urgent need and…

Marttila & Kiley, Inc., Boston, MA.

112

Higher professional education for general medical practitioners: key informant interviews and focus group findings.  

PubMed Central

BACKGROUND: If higher professional education (HPE) for general practitioners (GPs) is to be implemented, then key stakeholders will need to be supportive. AIM: To investigate stakeholders' beliefs about the concept of HPE, its funding, and relationships to education and care. METHOD: Interviews were conducted using a topic guide with a health authority (HA) representative, the Local Medical Committee Chair, the Medical Audit Advisory Group Chair, a GP tutor from each of the six health authorities in the old South West region, and a senior member of the three academic GP departments and the two Royal College of General Practitioners faculties in the region. Focus groups were held with GP registrars on both vocational training schemes (VTSs) and on the one HPE course in the region. These were recorded, transcribed verbatim, and analysed for emergent themes that were triangulated with the ideas expressed in the focus groups; the same topic guide was used for both. RESULTS: Of 29 key informants, 24 were interviewed. Six focus groups were held (the one HPE group and five out of the nine VTSs), after which no new ideas emerged. There is a transition period, after becoming a new principal (NP) and before becoming a fully competent independent GP, during which NPs need support. Benefits would include receiving peer support to reduce stress during the transition, enhanced non-clinical competencies, becoming a better skilled GP, avoiding the negative personal impact of a career as a GP, and helping recruitment. To improve patient care there must be a link between education and service provision. Funding is the major consideration in setting HPE; mixed funding is best coming from top-sliced General Medical Services (GMS), the HA, and regional educational funds. Barriers might include NPs' practice workload, their enthusiasm, and their partners' attitudes. The other key is a local enthusiast to initiate a course and coordinate the 'players'. The curriculum would be principally non-clinical and should be agreed by learners and the course tutor together, taking advice from various interested parties. CONCLUSION: There is a need for HPE for new NPs. It will require funding external to individual practices or NPs and a local enthusiast. Top-slicing of GMS funds is one source of funding, with additional funds from regional education and HAs. HPE must be related to service provision, to NP needs, and to vocational training. PMID:10897513

Smith, L F; Eve, R; Crabtree, R

2000-01-01

113

Research Infusion Collaboration: Finding Defect Patterns in Reused Code  

NASA Technical Reports Server (NTRS)

The 'Finding Defect Patterns in Reused Code' Research Infusion Collaboration was performed by Jet Propulsion Laboratory/Caltech under Contract 104-07-02.679 102 197 08.14.4. This final report describes the collaboration and documents the findings, including lessons learned.The research infusion collaboration characterized, using Orthogonal Defect Classification, defect reports for code that will be reused in mission-critical software on Deep Space Network Antenna controllers. Code reuse is estimated to be 90%, so it is important to identify systemic defects, or patterns, prior to reuse of this code. The work also identified ways to avoid certain types of defects and to test more efficiently.The primary objectives of the project were:to analyze defect patterns of the code to be reused based on the defects'Orthogonal Defect Classification (ODC)and to achieve a successful infusion of ODC to a project.

Lutz, Robyn R.; Morgan, Scott; Do, Tuan; Mikulski, Carmen; Berg Strain, Martha; Rockwell, Steve; Wilkinson, Belinda

2004-01-01

114

UCSD researchers find enzyme accelerates malignant stem cell cloning in chronic myeloid leukemia  

Cancer.gov

An international team, headed by researchers at the University of California, San Diego School of Medicine, has identified a key enzyme in the reprogramming process that promotes malignant stem cell cloning and the growth of chronic myeloid leukemia (CML), a cancer of the blood and marrow that experts say is increasing in prevalence. The findings are published in the Dec. 24 online early edition of the Proceedings of the National Academy of Sciences (PNAS). UCSD is home to the Moores Comprehensive Cancer Center.

115

Comorbid Forms of Psychopathology: Key Patterns and Future Research Directions  

Microsoft Academic Search

The purpose of this review is to systematically appraise the peer-reviewed literature about clustered forms of psychopathology and to present a framework that can be useful for studying comorbid psychiatric disorders. The review focuses on four of the most prevalent types of mental health problems: anxiety, depression, conduct disorder, and substance abuse. The authors summarize existing empirical research on the

Magdalena Cerd; Aditi Sagdeo; Sandro Gale

2008-01-01

116

Investigating Ideomotor Cognition with Motorvisual Priming Paradigms: Key Findings, Methodological Challenges, and Future Directions  

PubMed Central

Ideomotor theory claims that perceptual representations of action-effects are functionally involved in the planning of actions. Strong evidence for this claim comes from a phenomenon called motorvisual priming. Motorvisual priming refers to the finding that action planning directly affects perception, and that the effects are selective for stimuli that share features with the planned action. Motorvisual priming studies have provided detailed insights into the processing of perceptual representations in action planning. One important finding is that such representations in action planning have a categorical format, whereas metric representations are not anticipated in planning. Further essential findings regard the processing mechanisms and the time course of ideomotor cognition. Perceptual representations of action-effects are first activated by action planning and then bound into a compound representation of the action plan. This compound representation is stabilized throughout the course of the action by the shielding of all involved representations from other cognitive processes. Despite a rapid growth in the number of motorvisual priming studies in the current literature, there are still many aspects of ideomotor cognition which have not yet been investigated. These aspects include the scope of ideomotor processing with regard to action types and stimulus types, as well as the exact nature of the binding and shielding mechanisms involved. PMID:23189067

Thomaschke, Roland

2012-01-01

117

Transfer Velocity Project: Key Findings on Student Transfer in California Community Colleges  

ERIC Educational Resources Information Center

Which factors promote student transfer from California Community Colleges (CCC) to baccalaureate-granting institutions? How do community college practices support this transition? Which student behaviors and characteristics particularly facilitate their movement to four-year colleges and universities? The Research and Planning Group for California…

Research and Planning Group for California Community Colleges (RP Group), 2010

2010-01-01

118

Research findings can change attitudes about corporal punishment.  

PubMed

Positive attitudes toward the use of corporal punishment (CP) predict subsequent spanking behavior. Given that CP has frequently been associated with behavior problems in children and child maltreatment, this prevention work was designed to test whether adults' attitudes could be changed by informing participants about the research findings on problematic behaviors associated with CP. Two random assignment studies are reported. In Study 1, we tested whether an active reading condition would result in more attitude change than a passive condition. With a sample of 118 non-parent adults, we found that after reading very brief research summaries on the problems associated with CP, there was a significant decrease in favorable attitudes toward CP. Contrary to expectations, the magnitude of the change was comparable for active and passive processing conditions. In Study 2, we extended our approach to a sample of 520 parents and included a control group. A significant decrease in positive attitudes toward spanking was observed in the intervention group, but no change for the control group. Parents who were unaware of the research showed more change after reading the summaries. Thus, these studies demonstrate that a brief and cost-effective approach to raise awareness of research findings can reduce positive attitudes toward CP. Implications for prevention and intervention are discussed. PMID:24246718

Holden, George W; Brown, Alan S; Baldwin, Austin S; Croft Caderao, Kathryn

2014-05-01

119

Thomas Jefferson University study finds tissue around tumor holds key to fighting triple negative breast cancer  

Cancer.gov

A natural substance found in the surrounding tissue of a tumor may be a promising weapon to stop triple negative breast cancer from metastasizing. A preclinical study published in PLOS ONE September 19 by Thomas Jefferson University researchers found that decorin, a well-studied protein known to help halt tumor growth, induces a series of tumor suppressor genes in the surrounding tissue of triple negative breast cancer tumors that help stop metastasis. Thomas Jefferson University is home to the Kimmel Cancer Center.

120

Key Competencies and Characteristics for Innovative Teaching among Secondary School Teachers: A Mixed-Methods Research  

ERIC Educational Resources Information Center

This research aims to understand the key competencies and characteristics for innovative teaching as perceived by Chinese secondary teachers. A mixed-methods research was used to investigate secondary teachers' views. First, a qualitative study was conducted with interviews of teachers to understand the perceived key competencies and…

Zhu, Chang; Wang, Di

2014-01-01

121

Managing incidental findings and research results in genomic research involving biobanks and archived data sets.  

PubMed

Biobanks and archived data sets collecting samples and data have become crucial engines of genetic and genomic research. Unresolved, however, is what responsibilities biobanks should shoulder to manage incidental findings and individual research results of potential health, reproductive, or personal importance to individual contributors (using "biobank" here to refer both to collections of samples and collections of data). This article reports recommendations from a 2-year project funded by the National Institutes of Health. We analyze the responsibilities involved in managing the return of incidental findings and individual research results in a biobank research system (primary research or collection sites, the biobank itself, and secondary research sites). We suggest that biobanks shoulder significant responsibility for seeing that the biobank research system addresses the return question explicitly. When reidentification of individual contributors is possible, the biobank should work to enable the biobank research system to discharge four core responsibilities to (1) clarify the criteria for evaluating findings and the roster of returnable findings, (2) analyze a particular finding in relation to this, (3) reidentify the individual contributor, and (4) recontact the contributor to offer the finding. We suggest that findings that are analytically valid, reveal an established and substantial risk of a serious health condition, and are clinically actionable should generally be offered to consenting contributors. This article specifies 10 concrete recommendations, addressing new biobanks as well as those already in existence. PMID:22436882

Wolf, Susan M; Crock, Brittney N; Van Ness, Brian; Lawrenz, Frances; Kahn, Jeffrey P; Beskow, Laura M; Cho, Mildred K; Christman, Michael F; Green, Robert C; Hall, Ralph; Illes, Judy; Keane, Moira; Knoppers, Bartha M; Koenig, Barbara A; Kohane, Isaac S; Leroy, Bonnie; Maschke, Karen J; McGeveran, William; Ossorio, Pilar; Parker, Lisa S; Petersen, Gloria M; Richardson, Henry S; Scott, Joan A; Terry, Sharon F; Wilfond, Benjamin S; Wolf, Wendy A

2012-04-01

122

Psychological Therapies for Auditory Hallucinations (Voices): Current Status and Key Directions for Future Research  

PubMed Central

This report from the International Consortium on Hallucinations Research considers the current status and future directions in research on psychological therapies targeting auditory hallucinations (hearing voices). Therapy approaches have evolved from behavioral and coping-focused interventions, through formulation-driven interventions using methods from cognitive therapy, to a number of contemporary developments. Recent developments include the application of acceptance- and mindfulness-based approaches, and consolidation of methods for working with connections between voices and views of self, others, relationships and personal history. In this article, we discuss the development of therapies for voices and review the empirical findings. This review shows that psychological therapies are broadly effective for people with positive symptoms, but that more research is required to understand the specific application of therapies to voices. Six key research directions are identified: (1) moving beyond the focus on overall efficacy to understand specific therapeutic processes targeting voices, (2) better targeting psychological processes associated with voices such as trauma, cognitive mechanisms, and personal recovery, (3) more focused measurement of the intended outcomes of therapy, (4) understanding individual differences among voice hearers, (5) extending beyond a focus on voices and schizophrenia into other populations and sensory modalities, and (6) shaping interventions for service implementation. PMID:24936081

Thomas, Neil; Hayward, Mark; Peters, Emmanuelle; van der Gaag, Mark; Bentall, Richard P.; Jenner, Jack; Strauss, Clara; Sommer, Iris E.; Johns, Louise C.; Varese, Filippo; Garcia-Montes, Jose Manuel; Waters, Flavie; Dodgson, Guy; McCarthy-Jones, Simon

2014-01-01

123

Psychological therapies for auditory hallucinations (voices): current status and key directions for future research.  

PubMed

This report from the International Consortium on Hallucinations Research considers the current status and future directions in research on psychological therapies targeting auditory hallucinations (hearing voices). Therapy approaches have evolved from behavioral and coping-focused interventions, through formulation-driven interventions using methods from cognitive therapy, to a number of contemporary developments. Recent developments include the application of acceptance- and mindfulness-based approaches, and consolidation of methods for working with connections between voices and views of self, others, relationships and personal history. In this article, we discuss the development of therapies for voices and review the empirical findings. This review shows that psychological therapies are broadly effective for people with positive symptoms, but that more research is required to understand the specific application of therapies to voices. Six key research directions are identified: (1) moving beyond the focus on overall efficacy to understand specific therapeutic processes targeting voices, (2) better targeting psychological processes associated with voices such as trauma, cognitive mechanisms, and personal recovery, (3) more focused measurement of the intended outcomes of therapy, (4) understanding individual differences among voice hearers, (5) extending beyond a focus on voices and schizophrenia into other populations and sensory modalities, and (6) shaping interventions for service implementation. PMID:24936081

Thomas, Neil; Hayward, Mark; Peters, Emmanuelle; van der Gaag, Mark; Bentall, Richard P; Jenner, Jack; Strauss, Clara; Sommer, Iris E; Johns, Louise C; Varese, Filippo; García-Montes, José Manuel; Waters, Flavie; Dodgson, Guy; McCarthy-Jones, Simon

2014-07-01

124

Biobanking, consent, and control: a survey of Albertans on key research ethics issues.  

PubMed

While the development of large scale biobanks continues, ethics and policy challenges persist. Debate surrounds key issues such as giving and withdrawing consent, incidental findings and return of results, and ownership and control of tissue samples. Studies of public perception have demonstrated a lack of consensus on these issues, particularly in different jurisdictions. We conducted a telephone survey of members of the public in Alberta, Canada. The survey addressed the aforementioned issues, but also explored public trust in the individuals and institutions involved in biobanking research. Results show that the Alberta public is fairly consistent in their responses and that those who preferred a broad consent model were also less likely to desire continuing control and a right to withdraw samples. The study raises questions about the role of public perceptions and opinions, particularly in the absence of consensus. PMID:24845044

Caulfield, Timothy; Rachul, Christen; Nelson, Erin

2012-10-01

125

Embodiment of the interpersonal nexus: revealing qualitative research findings on shoulder surgery patients  

PubMed Central

Background The paper reports on the importance of the interpersonal nexus within qualitative research processes, from a recent research project on patient experiences of shoulder surgery. Our aim is to reveal the importance of qualitative research processes and specifically the role of the interpersonal nexus in generating quality data. Literature related to the importance of human interactions and interpersonal communication processes in health-related research remains limited. Shoulder surgery has been reported to be associated with significant postoperative pain. While shoulder surgery research has investigated various analgesic techniques to determine key efficacy and minimization of adverse side effects, little has been reported from the patient perspective. Methods Following institutional ethics approval, this project was conducted in two private hospitals in Victoria, Australia, in 2010. The methods included a survey questionnaire, semistructured interviews, and researcher-reflective journaling. Researcher-reflective journaling was utilized to highlight and discuss the interpersonal nexus. Results This research specifically addresses the importance of the contributions of qualitative methods and processes to understanding patient experiences of analgesic efficacy and shoulder surgery. The results reveal the importance of the established research process and the interwoven interpersonal nexus between the researcher and the research participants. The interpersonal skills of presencing and empathetic engagement are particularly highlighted. Conclusion The authors attest the significance of establishing an interpersonal nexus in order to reveal patient experiences of shoulder surgery. Interpersonal emotional engagement is particularly highlighted in data collection, in what may be otherwise understated and overlooked qualitative findings in patient experiences of shoulder surgery. PMID:22442632

Glass, Nel; Ogle, K Robyn

2012-01-01

126

Putting Research Findings to Work. ANPA News Research Report No. 31.  

ERIC Educational Resources Information Center

Twenty-six American Newspaper Publishers Association research reports published since 1978 are reviewed in this paper. The paper analyzes each of the reports in order to provide an overview of what their findings really say and what newspapers can do in their own market areas to use the findings to improve their product. Among the topics covered…

Mauro, John B.; Bonney, Christopher F.

127

Summary of EL Research Findings to Date. What Works. Research: The Implications for Professional Practice.  

ERIC Educational Resources Information Center

Summaries of research findings on the following topics are compiled in this document: (1) students in schools with well-equipped resource centers and teacher-librarians perform better on achievement tests; (2) developing student competence in research and study skills is most effective when integrated with classroom instruction through cooperative…

Haycock, Ken, Comp.

128

Key issues and research priorities in landscape ecology: An idiosyncratic synthesis  

Microsoft Academic Search

Landscape ecology has made tremendous progress in recent decades, but as a rapidly developing discipline it is faced with new problems and challenges. To identify the key issues and research priorities in landscape ecology, a special session entitled \\

Jianguo Wu; Richard Hobbs

2002-01-01

129

Online Information Exchanges for Parents of Children With a Rare Health Condition: Key Findings From an Online Support Community  

PubMed Central

Background The Internet provides new opportunities for parents of children with difficult illnesses and disabilities to find information and support. The Internet is particularly important for caregivers of children with special needs due to numerous health-related decisions they face. For at-risk populations, online support communities can become key settings and channels for health promotion and communication. Objective This study is an initial exploration of the information-seeking and information-provision processes present in an online support community, which is an area of opportunity and interest for Internet-based medical research and practice. The aim of this study was to explore and describe information-related processes of uncertainty management in relationship to clubfoot. Specifically, the study explored interpersonal communication (information seeking and provision) in an online support community serving the needs of parents of children with clubfoot. Methods The study population consisted of messages posted to an online community by caregivers (parents) of children with clubfoot. The theoretical framework informing the study was the Uncertainty Management Theory (UMT). The study used content analysis to explore and categorize the content of 775 messages. Results Women authored 664 of 775 messages (86%) and men authored 47 messages (6%). Caregivers managed uncertainty through information seeking and provision behaviors that were dynamic and multilayered. The ratio of information-seeking messages to information-provision responses was 1 to 4. All five types of information-seeking behaviors proposed by Brashers’ schema were identified, most of them being correlated. Information seeking using direct questions was found to be positively correlated to self-disclosure (r=.538), offering of a candidate answer (r=.318), and passive information seeking (r=.253). Self-disclosure was found to be positively correlated to provision of a candidate answer (r=.324), second-guessing (r=.149), and passive information seeking (r=.366). Provision of a candidate answer was found to be positively correlated with second-guessing (r=.193) and passive information seeking (r=.223). Second-guessing was found to be positively correlated to passive information seeking (r=.311). All correlations reported above were statistically significant (P<0.01). Of the 775 messages analyzed, 255 (33%) identified a medical professional or institution by name. Detailed medical information was provided in 101 (13%) messages, with the main source of information identified being personal experience rather than medical sources. Conclusion Online communities can be an effective channel for caregivers, especially women, to seek and offer information required for managing clubfoot-related uncertainty. To enhance communication with parents, health care institutions may need to invest additional resources in user-friendly online information sources and online interactions with caregivers of children with special illnesses such as clubfoot. Furthermore, explorations of information-seeking and information-provision behaviors in online communities can provide valuable data for interdisciplinary health research and practice. PMID:23470259

Campo, Shelly; Lowe, John; Andsager, Julie; Morcuende, Jose A

2013-01-01

130

A practical approach to incidental findings in neuroimaging research  

PubMed Central

Objective: We describe the systematic approach to incidental findings (IFs) used at the Mind Research Network (MRN) where all MRI scans receive neuroradiologist interpretation and participants are provided results. Methods: From 2004 to 2011, 8,545 MRI scans were acquired by 45 researchers. As mandated by MRN?s external institutional review board, all structural sequences were evaluated by a clinical neuroradiologist who generated a report that included recommendations for referral if indicated. Investigators received a copy of their participants' reports, which were also mailed to participants unless they specifically declined. To better understand the impact of the radiology review process, a financial analysis was completed in addition to a follow-up phone survey to characterize participant perceptions regarding receiving their MRI scan results. Results: The radiologist identified IFs in 34% of the 4,447 participants. Of those with IFs (n = 1,518), the radiologist recommended urgent or immediate referral for 2.5% and routine referral for 17%. For 80.5%, no referral was recommended. Estimated annual cost for this approach including support for the neuroradiologist, medical director, and ancillary staff is approximately $60,000 or $24/scan. The results of the retrospective phone survey showed that 92% of participants appreciated receiving their MRI report, and the majority stated it increased their likelihood of volunteering for future studies. Conclusions: Addressing IFs in a cost-effective and consistent manner is possible by adopting a policy that provides neuroradiology interpretation and offers participant assistance with clinical follow-up when necessary. Our experience suggests that an ethical, institution-wide approach to IFs can be implemented with minimal investigator burden. PMID:22131543

Holdsworth, M.T.; Aine, C.; Calhoun, V.D.; de La Garza, R.; Feldstein Ewing, S.W.; Hayek, R.; Mayer, A.R.; Kiehl, K.A.; Petree, L.E.; Sanjuan, P.; Scott, A.; Stephen, J.; Phillips, J.P.

2011-01-01

131

Taking aims seriously: repository research and limits on the duty to return individual research findings  

PubMed Central

Most discussions of researchers’ duties to return incidental findings or research results to research participants or repository contributors fail to provide an adequate theoretical grounding for such duties. Returning findings is a positive duty, a duty to help somebody. Typically, such duties are specified narrowly such that helping is only a duty when it poses little or no risk or burden to the helper and does not interfere with her legitimate aims. Under current budgetary and personnel constraints, and with currently available information technology, routine return of individual findings from research using repository materials would constitute a substantial burden on the scientific enterprise and would seriously frustrate the aims of both scientists and specimen/data contributors. In most cases, researchers’ limited duties to help repository contributors probably can be fulfilled by some action less demanding than returning individual findings. Furthermore, the duty-to-return issue should be analyzed as a conflict between (possibly) helping some contributors now and (possibly) helping a greater number of people who would benefit in the future from the knowledge produced by research. PMID:22402758

Ossorio, Pilar

2013-01-01

132

Effects of climate change on biodiversity: a review and identification of key research issues  

Microsoft Academic Search

Current knowledge of effects of climate change on biodiversity is briefly reviewed, and results are presented of a survey of biological research groups in the Netherlands, aimed at identifying key research issues in this field. In many areas of the world, biodiversity is being reduced by humankind through changes in land cover and use, pollution, invasions of exotic species and

Maarten Kappelle; Margret M. I. Van Vuuren; Pieter Baas

1999-01-01

133

42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.  

Code of Federal Regulations, 2011 CFR

...Health and Human Services Research Misconduct Issues § 93...no settlement or finding of research misconduct. When the final...a settlement or finding of research misconduct, ORI may: ...other actions authorized by...

2011-10-01

134

48 CFR 335.071 - Special determinations and findings affecting research and development contracting.  

Code of Federal Regulations, 2013 CFR

...findings affecting research and development contracting. 335.071...CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 335.071 ...findings affecting research and development contracting. OPDIV heads shall sign individual and...

2013-10-01

135

RESEARCH OPPORTUNITIES FOR LSU MEDICAL STUDENTS FINDING A FACULTY MENTOR  

E-print Network

). Students can work on research related to obesity, diabetes and kidney diseases. Medical Student Alcohol Institute of Diabetes and Digestive and Kidney Diseases supports summer research for LSU medical students research for LSU medical students in clinical or laboratory research related to diseases caused by alcohol

136

Freshwater findings, 1976-1978. Research publications of the Environmental Research Laboratory, Duluth, Minnesota. Bibliography report  

SciTech Connect

This bibliography, inclusive from 1976 through 1978 lists all publications authored by personnel of the Environmental Research Laboratory-Duluth. Some of the research findings were to determine how physical and chemical pollution affects aquatic life; to assess the effects of ecosystems on pollutants; to predict effects of pollutants on large lakes through use of models; to measure bioaccumulation of pollutants in aquatic organisms that are consumed by other animals, including man.

Russom, C.

1980-01-01

137

Designing a knowledge transfer and exchange strategy for the Alberta Depression Initiative: contributions of qualitative research with key stakeholders  

PubMed Central

Background Depressive disorders are highly prevalent and of significant societal burden. In fall 2004, the 'Alberta Depression Initiative' (ADI) research program was formed with a mission to enhance the mental health of the Alberta population. A key expectation of the ADI is that research findings will be effectively translated to appropriate research users. To help ensure this, one of the initiatives funded through the ADI focused specifically on knowledge transfer and exchange (KTE). The objectives of this project were first to examine the state of the KTE literature, and then based on this review and a set of key informant interviews, design a KTE strategy for the ADI. Methods Face to face interviews were conducted with 15 key informants familiar with KTE and/or mental health policy and programs in Alberta. Interviews were transcribed and analyzed using the constant comparison method. Results This paper reports on findings from the qualitative interviews. Respondents were familiar with the barriers to and facilitators of KTE as identified in the existing literature. Four key themes related to the nature of effective KTE were identified in the data analysis: personal relationships, cultivating champions, supporting communities of practice, and building receptor capacity. These recommendations informed the design of a contextually appropriate KTE strategy for the ADI. The three-phased strategy involves preliminary research, public workshops, on-going networking and linkage activities and rigorous evaluation against pre-defined and mutually agreed outcome measures. Conclusion Interest in KTE on the part of ADI has led to the development of a strategy for engaging decision makers, researchers, and other mental health stakeholders in an on-going network related to depression programs and policy. A similarly engaged process might benefit other policy areas. PMID:19523226

Mitton, Craig; Adair, Carol E; McKenzie, Emily; Patten, Scott; Waye-Perry, Brenda; Smith, Neale

2009-01-01

138

Research Findings - Part III: Expectations Drive Effective College Recruitment Strategies  

ERIC Educational Resources Information Center

IDRA interviewed different groups of respondents at San Antonio College to identify the most critical factors that impacted a decision to enroll in college and graduate. Focus group and individual interviews targeted key stakeholders, including: high school administrators, counselors, high school students, parents of high school students, and…

Cortez, Albert; Cortez, Josie Danini

2004-01-01

139

Research finds brain link for words, music ability  

E-print Network

research suggests that intensive musical therapy may help improve speech in stroke patients, researchers. In addition, researchers said, music education can help children with developmental dyslexia or autism more sing, he said. Now, they are doing trials to see if music can be used as a therapy. But, he cautioned

Kraus, Nina

140

Columbia University Medical Center researchers find that a new computational approach finds gene that drives aggressive brain cancer  

Cancer.gov

Columbia University Medical Center researchers have combined existing computational tools with a new algorithm called DIGGIT, which 'walks' backward from the master regulators to find the genetic events that drive brain cancer.

141

Offshore Software Development: Transferring Research Findings into the Classroom  

Microsoft Academic Search

Distributed software projects are becoming increasingly commonplace in industry. Yet, software engineering education rarely\\u000a graduates students with the necessary skills and hands-on experience that are particular to off-shore software development\\u000a projects. Three key areas in successful off-shore software development projects are well documented in the literature as communication,\\u000a knowledge management, as well as project and process management. This paper maps

Kay Berkling; Michael Geisser; Tobias Hildenbrand; Franz Rothlauf

2007-01-01

142

Applying Ad Hoc Institutional Research Findings to College Strategic Planning  

ERIC Educational Resources Information Center

Environmental scanning, enrollment forecasting, budget analyses, and institutional effectiveness assessment are examples of the explicit contributions institutional research offices make to campus strategic planning.

Clagett, Craig A.

2004-01-01

143

Action Research Project: Prof 190-191 Finding Journal Articles  

E-print Network

education databases. PPhhrraasseess "attention deficit hyperactivity disorder" BBoooolleeaann OOppeerraattoorrss:: OORR,, NNOOTT ((ddeeffaauulltt iiss AANNDD)) adhd OR "attention deficit" "differentiated by Queen's. use the Cited by feature to find related articles. PPhhrraasseess "attention deficit

Abolmaesumi, Purang

144

The current structure of key actors involved in research on land and soil degradation  

NASA Astrophysics Data System (ADS)

Land and soil conservation topics, the final mandate of the United Convention to Combat desertification in drylands, have been diagnosed as still suffering from a lack of guidance. On the contrary, climate change and biodiversity issues -the other two big subjects of the Rio Conventions- seem to progress and may benefit from the advice of international panels. Arguably the weakness of policy measures and hence the application of scientific knowledge by land users and stakeholders could be the expression of an inadequate research organization and a lack of ability to channel their findings. In order to better understand the size, breadth and depth of the scientific communities involved in providing advice to this convention and to other bodies, this study explores the corpus of international publications dealing with land and/or with soils. A database of several thousands records including a significant part of the literature published so far was performed using the Web of Science and other socio-economic databases such as FRANCIS and CAIRN. We extracted hidden information using bibliometric methods and data mining applied to these scientific publications to map the key actors (laboratories, teams, institutions) involved in research on land and on soils. Several filters were applied to the databases in combination with the word "desertification". The further use of Tetralogie software merges databases, analyses similarities and differences between keywords, disciplines, authors and regions and identifies obvious clusters. Assessing their commonalities and differences, the visualisation of links and gaps between scientists, organisations, policymakers and other stakeholders is possible. The interpretation of the 'clouds' of disciplines, keywords, and techniques will enhance the understanding of interconnections between them; ultimately this will allow diagnosing some of their strengths and weaknesses. This may help explain why land and soil degradation remains a serious global problem that lacks sufficient attention. We hope that this study will contribute to clarify the scientific landscape at stake to remediate possible weaknesses in the future.

Escadafal, Richard; Barbero, Celia; Exbrayat, Williams; Marques, Maria Jose; Ruiz, Manuel; El Haddadi, Anass; Akhtar-Schuster, Mariam

2013-04-01

145

"Response to Comments": Finding the Narrative in Narrative Research  

ERIC Educational Resources Information Center

The author responds to comments by Barone (2009), Clandinin and Murphy (2009), and M. W. Smith (2009) on "The Construction Zone: Literary Elements in Narrative Research" (Coulter & M. L. Smith, 2009). She clarifies issues regarding point of view, authorial surplus, narrative coherence, and the relational qualities of narrative research. She…

Coulter, Cathy A.

2009-01-01

146

Findings from research on divorce: implications for professionals' skill development.  

PubMed

Results from research on divorce are synthesized, and practical implications for the development of conceptual, perceptual, and executive skills for educators, lawyers, mental health clinicians, health care professionals, social policy planners, and the media are presented. An interdisciplinary approach to intervention is proposed, and recommendations for future research on divorce are made. PMID:6610363

Leahey, M

1984-04-01

147

Training Methods; An Analysis of the Research Findings.  

ERIC Educational Resources Information Center

To report research on different instructional methods and variables, to indicate limitations of the research, and to suggest criteria for methods for particular learning goals, this review discusses and evaluates several major instructional methods: lectures, lesson-demonstration, programed instruction, case studies, tutorials, brainstorming,…

Royal Air Force (England). Technical Training Command.

148

Reform Programs Backed by Research Find Fewer Takers  

ERIC Educational Resources Information Center

This article discusses the waning interests on research-based models. Some experts and program developers say "research proven" programs are getting a smaller and smaller share of the pie under the 7-year-old initiative now called the Comprehensive School Reform program, as schools opt instead for home-grown and commercial programs with weaker…

Viadero, Debra

2004-01-01

149

Finding Nexus: Connecting Youth Work and Research Practices  

ERIC Educational Resources Information Center

Participation in educational and social research helps to develop understanding of how young people learn and to consider wider aspects of their lives to enable their voices to be heard and acted upon. Research also facilitates the articulation and sharing of methodologies across a range of professional practices. We assert that theory and…

Gormally, Sinéad; Coburn, Annette

2014-01-01

150

Finding the Fabulous Few: Why Your Program Needs Sophisticated Research.  

ERIC Educational Resources Information Center

Fund raising, it is argued, needs sophisticated prospect research. Professional prospect researchers play an important role in helping to identify prospective donors and also in helping to stimulate interest in gift giving. A sample of an individual work-up on a donor and a bibliography are provided. (MLW)

Pfizenmaier, Emily

1981-01-01

151

Dabrowski's Theory of Positive Disintegration and Giftedness: Overexcitability Research Findings  

ERIC Educational Resources Information Center

During the past 20 years, a significant body of literature has emerged focusing on the application of Dabrowski's theory of positive disintegration (TPD) to the study of gifted individuals. Although much of this literature is prescriptive, some research reports spanning this time period are available. A perusal of research on TPD's applicability…

Mendaglio, Sal; Tillier, William

2006-01-01

152

Researchers find nanodiamonds could improve effectiveness of breast cancer treatment  

Cancer.gov

UCLA researchers and collaborators have developed a potentially more effective treatment for "triple-negative" breast cancer that uses nanoscale, diamond-like particles called nanodiamonds. Nanodiamonds are between 4 and 6 nanometers in diameter and are shaped like tiny soccer balls. Byproducts of conventional mining and refining operations, the particles can form clusters following drug binding and have the ability to precisely deliver cancer drugs to tumors, significantly improving the drugs' desired effect. UCLA is home to the Jonsson Comprehensive Cancer Center. The research team included contributors from the NanoCarbon Research Institute in Nagano, Japan and UC San Francisco, home of the Helen Diller Family Comprehensive Cancer Center.

153

MD Anderson researchers find that yoga regulates stress hormones  

Cancer.gov

Through a grant from the National Cancer Institute, researchers are now conducting a Phase III clinical trial in women with breast cancer to further determine the mechanisms of yoga that lead to improvement in physical functioning and quality of life.

154

Roswell Park researchers find prognostic biomarker candidates for ovarian cancer  

Cancer.gov

Cancer researchers at Roswell Park Cancer Institute have identified two independent classes of novel candidate prognostic markers for ovarian cancer, advancing efforts to develop targeted therapies for the disease.

155

Find the Expert at the Agricultural Research Service  

NSDL National Science Digital Library

The United States Department of Agriculture's Agricultural Research Service now offers a feature where users can directly ask questions of Agricultural experts. Searching is possible in three ways: Keyword, Broad Subject Area, or Research Area. Typical search results include lists of experts with contact addresses, including email. With subject areas ranging from Air Quality and Mitigation to Weeds, this service adds a nice notch in the measuring stick of improved scientific communication.

156

MD Anderson researchers find coupling of proteins promotes glioblastoma development:  

Cancer.gov

Two previously unassociated proteins known to be overly active in a variety of cancers bind together to ignite and sustain malignant brain tumors, a research team led by scientists at The University of Texas MD Anderson Cancer Center reports this week in the journal Cancer Cell. This research is the first to connect FoxM1 to a molecular signaling cascade that regulates normal neural stem cells...

157

Findings of the International Road Tunnel Fire Detection Research Project  

Microsoft Academic Search

\\u000a Abstract\\u000a   Fire detection systems play a crucial role in ensuring safe evacuation and firefighting operations in road tunnels, but information\\u000a on the performance of these systems in tunnels has been limited and guidelines for their application in tunnel environments\\u000a are not fully developed. Recently, the National Research Council of Canada (NRC) and the Fire Protection Research Foundation\\u000a completed a 2-year

Z. G. Liu; A. Kashef; G. Crampton; G. Lougheed; Y. Ko; G. Hadjisophocleous; Kathleen H. Almand

2010-01-01

158

Findings of the International Road Tunnel Fire Detection Research Project  

Microsoft Academic Search

Fire detection systems are essential fire protection elements for road tunnels to detect fires, activate safety systems and\\u000a direct evacuation and firefighting. However, information on the performance of these systems is limited and guidelines for\\u000a application of tunnel fire detection systems are not fully developed. The National Research Council of Canada and the Fire\\u000a Protection Research Foundation, with support of

A. Kashef; Z. G. Liu; G. Lougheed; G. Crampton; K. Yoon; G. Hadjisophocleous; Kathleen H. Almand

2009-01-01

159

Building and Strengthening Policy Research Capacity: Key Issues in Canadian Higher Education  

ERIC Educational Resources Information Center

Given the importance of higher education in social and economic development, governments need to build a strong higher education data and policy research infrastructure to support informed decision-making, provide policy advice, and offer a critical assessment of key trends and issues. The author discusses the decline of higher education policy…

Jones, Glen A.

2014-01-01

160

SUMMARY OF RESEARCH FINDINGS IN OFF-FARM AGRICULTURAL OCCUPATIONS.  

ERIC Educational Resources Information Center

AS A RESULT OF TWO CONFERENCES HELD IN 1963-64, INTERVIEW-TYPE SURVEYS OF EMPLOYMENT NEEDS IN OFF-FARM AGRICULTURAL BUSINESSES WERE CONDUCTED IN 26 STATES IN 1964. THE ANALYSIS OF THE FINDINGS RESULTED IN THIS SYNTHESIS. INFORMATION IS GIVEN ON -- (1) NUMBERS OF PEOPLE EMPLOYED, (2) PRESENT NUMBER, ESTIMATED INCREASE, OCCUPATIONAL GROUP AND LEVEL…

Ohio State Univ., Columbus. Center for Vocational and Technical Education.

161

U of Chicago researchers find that STING pathway could be key to tumor immunity  

Cancer.gov

A protein complex known as STING plays a crucial role in detecting the presence of tumor cells and promoting an aggressive anti-tumor response by the body's innate immune system, according to two separate studies in Immunity.

162

Trends in Chicago's Schools across Three Eras of Reform: Summary of Key Findings. Research Summary  

ERIC Educational Resources Information Center

In 1988, U.S. Secretary of Education William Bennett proclaimed Chicago's public schools to be the worst in the nation. Since that time, Chicago has been at the forefront of urban school reform. Beginning with a dramatic move in 1990 to shift power away from the central office, through CEO Paul Vallas's use of standardized testing to hold schools…

Luppescu, Stuart; Allensworth, Elaine M.; Moore, Paul; de la Torre, Marisa; Murphy, James

2011-01-01

163

Key issues and research priorities in landscape ecology: An idiosyncratic Jianguo Wu1,* and Richard Hobbs2  

E-print Network

Key issues and research priorities in landscape ecology: An idiosyncratic synthesis Jianguo Wu1,* and Richard Hobbs2 1 Department of Plant Biology, Arizona State University, Tempe, AZ 85287-1601, USA; 2 Key words: Key issues, Landscape ecology, Research priorities and challenges Abstract Landscape

Wu, Jianguo "Jingle"

164

Research on Faculty Networks Network findings page 1  

E-print Network

faculty, especially women and racial minorities. We do this by asking four general categories of research and gender. It is also unknown how department network structure and actor positions within those networks's perception of his or her environment. Network analysis is a set of statistical methods for systematically

Farritor, Shane

165

Pain, Nicotine, and Smoking: Research Findings and Mechanistic Considerations  

ERIC Educational Resources Information Center

Tobacco addiction and chronic pain represent 2 highly prevalent and comorbid conditions that engender substantial burdens upon individuals and systems. Interrelations between pain and smoking have been of clinical and empirical interest for decades, and research in this area has increased dramatically over the past 5 years. We conceptualize the…

Ditre, Joseph W.; Brandon, Thomas H.; Zale, Emily L.; Meagher, Mary M.

2011-01-01

166

Survey of Undergraduate Research Experiences (SURE): First Findings  

ERIC Educational Resources Information Center

In this study, I examined the hypothesis that undergraduate research enhances the educational experience of science undergraduates, attracts and retains talented students to careers in science, and acts as a pathway for minority students into science careers. Undergraduates from 41 institutions participated in an online survey on the benefits of…

Lopatto, David

2004-01-01

167

A Normative Study of Children's Drawings: Preliminary Research Findings  

ERIC Educational Resources Information Center

This paper describes methodology, data analysis, and initial results of a research study with the long-term goal of establishing contemporary normative data on drawings from children living in the United States. The pool of participants was composed of 316 fourth graders (mean age 9.69 years) and 151 second graders (mean age 7.56 years) who each…

Deaver, Sarah P.

2009-01-01

168

The Atlanta Slayings: Telecommunications Research Supplies New Findings.  

ERIC Educational Resources Information Center

Compares the influence of television news on the reactions of 100 Blacks in both Georgia and Iowa to the Atlanta slayings. People surveyed were examined for their reactions to live coverage, newsmaker interviews, wire service reports, and news writers and researchers. Eight references are listed. (MER)

Lehane, Stephen; Braman, Gary

1982-01-01

169

Researchers Find That Childhood Sarcoma Increases Risk of Blood Clots  

Cancer.gov

Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, have determined that children and young adults with a form of cancer called sarcoma are at increased risk of having a thromboembolic event (TE) in their veins.

170

UT Southwestern researchers find new gene mutations for Wilms Tumor  

Cancer.gov

Researchers at UT Southwestern Medical Center and the Gill Center for Cancer and Blood Disorders at Children’s Medical Center, Dallas, have made significant progress in defining new genetic causes of Wilms tumor, a type of kidney cancer found only in children.

171

Emerging Answers: Research Findings on Programs To Reduce Teen Pregnancy.  

ERIC Educational Resources Information Center

This report summarizes three bodies of research on teenage pregnancy and programs to reduce the risk of teenage pregnancy. Studies included in this report were completed in 1980 or later, conducted in the United States or Canada, targeted adolescents, employed an experimental or quasi-experimental design, had a sample size of at least 100 in the…

Kirby, Douglas

172

The Sponsored Research Lifecycle Part I: Finding a Sponsor  

E-print Network

with relationship building, discovery of customer needs, advocacy for your solution and support of the customer Research? #12;US 2003 R&D by Source & Performer Federal Funding is the primary sustenance for academic and Library Services National Aeronautics and Space Administration (NASA) National Council on Disability

Bieber, Michael

173

Pain, Nicotine, and Smoking: Research Findings and Mechanistic Considerations  

Microsoft Academic Search

Tobacco addiction and chronic pain represent 2 highly prevalent and comorbid conditions that engender substantial burdens upon individuals and systems. Interrelations between pain and smoking have been of clinical and empirical interest for decades, and research in this area has increased dramatically over the past 5 years. We conceptualize the interaction of pain and smoking as a prototypical example of

Joseph W. Ditre; Thomas H. Brandon; Emily L. Zale; Mary M. Meagher

2011-01-01

174

Electrical Distribution. Project Report Phase I with Research Findings.  

ERIC Educational Resources Information Center

This report provides results of Phase I of a project that researched the occupational area of electrical distribution, established appropriate committees, and conducted task verification. These results are intended to guide development of a program designed to train apprentice line workers. Section 1 contains general information: purpose of Phase…

Sappe', Hoyt; Kirkpatrick, Thomas

175

Reconciling (Seemingly) Discrepant Findings: Implications for Practice and Future Research  

ERIC Educational Resources Information Center

Decades of research in survey methodology and psychology have yielded important insights about how to create effective and valid survey instruments. As Porter (in press) has argued convincingly, college student surveys often fall well short of these standards by placing unrealistic demands on students' memory and by assuming that students readily…

Bowman, Nicholas A.; Herzog, Serge

2011-01-01

176

Youth Sports: Implementing Findings and Moving Forward with Research  

Microsoft Academic Search

This paper reviews the literature, outlines practical implications, and discusses future studies in youth sport research. The literature is discussed in light of three potential benefits of youth sport participation 1) physical health, 2) psycho-social development, and 3) motor skills acquisition. The ultimate objective of youth sport programs is to consider all the benefits of youth sport participation rather than

Jessica Fraser-Thomas; Jean Côté

177

Dental Laboratory Technology. Project Report Phase I with Research Findings.  

ERIC Educational Resources Information Center

This report provides results of Phase I of a project that researched the occupational area of dental laboratory technology, established appropriate committees, and conducted task verification. These results are intended to guide development of a program designed to train dental laboratory technicians. Section 1 contains general information:…

Sappe', Hoyt; Smith, Debra S.

178

FINDING THE BALANCE - QUALITY ASSURANCE REQUIREMENTS VS. RESEARCH NEEDS  

EPA Science Inventory

Investigators often misapply quality assurance (QA) procedures and may consider QA as a hindrance to developing test plans for sampling and analysis. If used properly, however, QA is the driving force for collecting the right kind and proper amount of data. Researchers must use Q...

179

FINDING THE BALANCE - QUALITY ASSURANCE REQUIREMENTS VS. RESEARCH NEEDS  

EPA Science Inventory

Investigators often misapply quality assurance (QA) procedures and may consider QA as a hindrance to developing test plans for sampling and analysis. If used properly, however, QA is the driving force for collecting the right kind and proper amount of data. Researchers must...

180

Oersted Medal Lecture 2001: "Physics Education Research-The Key to Student Learning"  

NSDL National Science Digital Library

Research on the learning and teaching of physics is essential for cumulative improvement in physics instruction. Pursuing this goal through systematic research is efficient and greatly increases the likelihood that innovations will be effective beyond a particular instructor or institutional setting. The perspective taken is that teaching is a science as well as an art. Research conducted by physicists who are actively engaged in teaching can be the key to setting high (yet realistic) standards, to helping students meet expectations, and to assessing the extent to which real learning takes place.

Mcdermott, Lillian C.

2005-10-27

181

Mental health epidemiological research in South America: recent findings  

PubMed Central

This paper aims to review the recent mental health epidemiological research conducted in South America. The Latin American and the Caribbean (LILACS) database was searched from 1999 to 2003 using a specific strategy for identification of cohort, case-control and cross-sectional population-based studies in South America. The authors screened references and identified relevant studies. Further studies were obtained contacting local experts in epidemiology. 140 references were identified, and 12 studies were selected. Most selected studies explored the prevalence and risk factors for common mental disorders, and several of them used sophisticated methods of sample selection and analysis. There is a need for improving the quality of psychiatric journals in Latin America, and for increasing the distribution and access to research data. Regionally relevant problems such as violence and substance abuse should be considered in designing future investigations in this area. PMID:16633474

Silva de Lima, Mauricio; Garcia de Oliveira Soares, Bernardo; de Jesus Mari, Jair

2004-01-01

182

42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.  

Code of Federal Regulations, 2013 CFR

...HHS action with settlement or finding of research misconduct. 93.411 Section 93...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.411...

2013-10-01

183

42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.  

Code of Federal Regulations, 2012 CFR

...HHS action with settlement or finding of research misconduct. 93.411 Section 93...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.411...

2012-10-01

184

42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.  

Code of Federal Regulations, 2012 CFR

... 2012-10-01 false Findings of research misconduct and proposed administrative...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.404...

2012-10-01

185

42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.  

Code of Federal Regulations, 2013 CFR

... 2013-10-01 false Findings of research misconduct and proposed administrative...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.404...

2013-10-01

186

Gate valve and motor-operator research findings  

SciTech Connect

This report provides an update on the valve research being sponsored by the US Nuclear Regulatory Commission (NRC) and conducted at the Idaho National Engineering Laboratory (INEL). The research addresses the need to provide assurance that motor-operated valves can perform their intended safety function, usually to open or close against specified (design basis) flow and pressure loads. This report describes several important developments: Two methods for estimating or bounding the design basis stem factor (in rising-stem valves), using data from tests less severe than design basis tests; a new correlation for evaluating the opening responses of gate valves and for predicting opening requirements; an extrapolation method that uses the results of a best effort flow test to estimate the design basis closing requirements of a gate valve that exhibits atypical responses (peak force occurs before flow isolation); and the extension of the original INEL closing correlation to include low- flow and low-pressure loads. The report also includes a general approach, presented in step-by-step format, for determining operating margins for rising-stem valves (gate valves and globe valves) as well as quarter-turn valves (ball valves and butterfly valves).

Steele, R. Jr.; DeWall, K.G.; Watkins, J.C.; Russell, M.J.; Bramwell, D.

1995-09-01

187

Tobacco cessation in dental settings: research findings and future directions.  

PubMed

The hazards associated with cigarette smoking and smokeless tobacco use have been well documented. In addition to its association with many cancers and coronary conditions, tobacco plays a role in the aetiology of a number of oral morbidities. Dental care practitioners are a largely untapped resource for providing advice and brief counselling to tobacco-using patients, and there are good reasons to believe that they can be effective. Data from seven randomised trials indicate there is ample evidence for the efficacy of dental office-based interventions, but adoption of these tobacco cessation activities into practice has been slow. The limited research on dissemination of tobacco interventions is promising, but there is a need to develop and evaluate new methods for encouraging adoption, implementation and maintenance of tobacco interventions into routine dental care. Several studies currently under way may help to increase the effectiveness and dissemination of office-based tobacco cessation programmes into routine dental care. If dental practitioners provided cessation assistance routinely to their patients and achieved even modest success rates, the public health impact would be enormous. Researchers and clinicians must continue to work together towards universal adoption of effective tobacco cessation interventions at each clinical encounter. PMID:16492575

Gordon, Judith S; Lichtenstein, Edward; Severson, Herbert H; Andrews, Judy A

2006-01-01

188

Recommendations for sex/gender neuroimaging research: key principles and implications for research design, analysis, and interpretation.  

PubMed

Neuroimaging (NI) technologies are having increasing impact in the study of complex cognitive and social processes. In this emerging field of social cognitive neuroscience, a central goal should be to increase the understanding of the interaction between the neurobiology of the individual and the environment in which humans develop and function. The study of sex/gender is often a focus for NI research, and may be motivated by a desire to better understand general developmental principles, mental health problems that show female-male disparities, and gendered differences in society. In order to ensure the maximum possible contribution of NI research to these goals, we draw attention to four key principles-overlap, mosaicism, contingency and entanglement-that have emerged from sex/gender research and that should inform NI research design, analysis and interpretation. We discuss the implications of these principles in the form of constructive guidelines and suggestions for researchers, editors, reviewers and science communicators. PMID:25221493

Rippon, Gina; Jordan-Young, Rebecca; Kaiser, Anelis; Fine, Cordelia

2014-01-01

189

Recommendations for sex/gender neuroimaging research: key principles and implications for research design, analysis, and interpretation  

PubMed Central

Neuroimaging (NI) technologies are having increasing impact in the study of complex cognitive and social processes. In this emerging field of social cognitive neuroscience, a central goal should be to increase the understanding of the interaction between the neurobiology of the individual and the environment in which humans develop and function. The study of sex/gender is often a focus for NI research, and may be motivated by a desire to better understand general developmental principles, mental health problems that show female-male disparities, and gendered differences in society. In order to ensure the maximum possible contribution of NI research to these goals, we draw attention to four key principles—overlap, mosaicism, contingency and entanglement—that have emerged from sex/gender research and that should inform NI research design, analysis and interpretation. We discuss the implications of these principles in the form of constructive guidelines and suggestions for researchers, editors, reviewers and science communicators.

Rippon, Gina; Jordan-Young, Rebecca; Kaiser, Anelis; Fine, Cordelia

2014-01-01

190

Findings of the US Research Needs Workshop on the Topic of Fusion Power  

SciTech Connect

The US Department of Energy, Office of Fusion Energy Sciences (OFES) conducted a Research Needs Workshop, referred to as ReNeW, in June 2009. The information developed at this workshop will help OFES develop a plan for US fusion research during the ITER era, roughly the next two decades. The workshop was organized in five Themes, one of which was Harnessing Fusion Power (or Fusion Power for short). The top level goal of the Fusion Power Theme was to identify the research needed to develop the knowledge to design and build, with high confidence, robust and reliable systems that can convert fusion products to useful forms of energy in a reactor environment, including a self-sufficient supply of tritium fuel. Each Theme was subsequently subdivided into Panels to address specific topics. The Fusion Power Panel topics were: fusion fuel cycle; power extraction; materials science; safety and environment; and reliability, availability, maintainability and inspectability (RAMI). Here we present the key findings of the Fusion Power Theme.

Meier, W R; Raffray, A R; Kurtz, R J; Morley, N B; Reiersen, W T; Sharpe, P; Willms, S

2009-09-16

191

Findings of the US research needs workshop on the topic of fusion power  

SciTech Connect

The US Department of Energy, Office of Fusion Energy Sciences (OFES) conducted a Research Needs Workshop, referred to as ReNeW, in June 2009. The information developed at this workshop will help OFES develop a plan for US fusion research during the ITER era, roughly the next two decades. The workshop was organized in five Themes, one of which was Harnessing Fusion Power (or Fusion Power for short). The top level goal of the Fusion Power Theme was to identify the research needed to develop the knowledge to design and build, with high confidence, robust and reliable systems that can convert fusion products to useful forms of energy in a reactor environment, including a self-sufficient supply of tritium fuel. Each Theme was subsequently subdivided into Panels to address specific topics. The Fusion Power Panel topics were: Fusion Fuel Cycle; Power Extraction; Materials Science; Safety and Environment; and Reliability, Availability, Maintainability and Inspectability (RAMI). Here we present the key findings of the Fusion Power Theme.

W. R. Meier; A. R. Raffray; R. J. Kurtz; N. B. Morley; W. T. Reiersen; Phil Sharpe; S. Willms

2010-12-01

192

Pigeon-Talk > Pigeon Daily > News New research finds people and pigeons see  

E-print Network

#1 Pigeon-Talk > Pigeon Daily > News New research finds people and pigeons see eye to eye User Name New research finds people and pigeons see eye to eye http://tinyurl.com/34558f DURHAM, N.H. ­ Pigeons to the development of flying robots and unmanned helicopters," the researchers say. So a software engineer who wants

Gosselin, Frédéric

193

Practicing Psychologists’ Knowledge of General Psychotherapy Research Findings: Implications for Science–Practice Relations  

Microsoft Academic Search

If you are a therapist, how knowledgeable are you and how knowledgeable do you need to be about psychotherapy research findings? In this study, the authors examined practicing psychologists’ knowledge of general psychotherapy research findings. Results revealed that some psychologists showed excellent familiarity with this body of outcome research, but many did not achieve this standard. Not infrequently, psychologists believed

Charles M. Boisvert; David Faust

2006-01-01

194

Study led by St. Jude finds key regulatory genes often amplified in aggressive childhood tumor of the brainstem:  

Cancer.gov

The largest study ever of a rare childhood brain tumor found more than half the tumors carried extra copies of specific genes linked to cancer growth, according to research led by St. Jude Children’s Research Hospital investigators.

195

Key Findings www.npc.umich.eduGerald R. Ford School of Public Policy, University of Michigan  

E-print Network

, March 2012 Policy Brief The National Poverty Center's Policy Brief series summarizes key academic. Sample citation: "Title, National Poverty Center Policy Brief #x". Housing Instability and Health to meet criteria for major or minor depression and to have had a recent anxiety attack. · Homelessness

Edwards, Paul N.

196

Understanding price elasticities to inform public health research and intervention studies: key issues.  

PubMed

Pricing policies such as taxes and subsidies are important tools in preventing and controlling a range of threats to public health. This is particularly so in tobacco and alcohol control efforts and efforts to change dietary patterns and physical activity levels as a means of addressing increases in noncommunicable diseases. To understand the potential impact of pricing policies, it is critical to understand the nature of price elasticities for consumer products. For example, price elasticities are key parameters in models of any food tax or subsidy that aims to quantify health impacts and cost-effectiveness. We detail relevant terms and discuss key issues surrounding price elasticities to inform public health research and intervention studies. PMID:24028228

Nghiem, Nhung; Wilson, Nick; Genç, Murat; Blakely, Tony

2013-11-01

197

Recent research related to juvenile sex offending: findings and directions for further research.  

PubMed

Serious scholarly inquiry into juvenile sex offending represents a relatively new field, dating from the mid 1940s. During the next 4 decades, a mere handful of articles exploring aspects of juvenile sex offending were added to the available literature. By the 1980s, however, the literature began to increase rapidly, a trend that continues today. The purpose of this article is a focused review of the juvenile sex offender literature cited in PubMed over the last 5 years (2009-2013). The authors have chosen studies that will bring readers up to date on research they believe impacts our current understanding of best practices in the management of juvenile sex offending. For convenience, our review is organized into topical categories including research into characteristics and typologies of juvenile sex offenders, risk assessment and recidivism, assessment and treatment, the ongoing debate about mandatory registration of sex offenders as it applies to juveniles, and other thought provoking studies that do not fit neatly into the aforementioned categories. The studies included contain findings that both reinforce and challenge currently held notions about best practices concerning treatment and public policy, suggesting that our knowledge of the field continues to evolve in important ways. PMID:24562765

Malin, H Martin; Saleh, Fabian M; Grudzinskas, Albert J

2014-04-01

198

NIAMS-Supported Research Finds New Genetic Links to Juvenile Arthritis  

MedlinePLUS

... 2003 2002 2001 2000 1999 Spotlight on Research 2013 June 2013 NIAMS-Supported Research Finds New Genetic Links to ... susceptibility loci for juvenile idiopathic arthritis. Nat Genet. 2013 Apr 21. doi: 10.1038/ng.2614. [Epub ...

199

Incidental Computer Tomography Radiologic Findings through Research Participation in the North Texas Healthy Heart Study  

PubMed Central

Background Although variation exists in the classification and practice of managing clinical findings in research, emerging views suggest that researchers bear some responsibility in the management of incidental findings. This study contributes to the documentation of the population characteristics and prevalence of medical findings incidental to research participation, specifically findings related to coronary calcium scores and computed tomography (CT) scans that investigated cardiovascular disparities in an asymptomatic population. Methods A total of 571 asymptomatic adult participants were recruited in the North Texas Healthy Heart Study. Participants completed a 16-slice CT scan of the heart and abdomen. Findings of radiology reports and 3 years of follow-up documentation were reviewed. Results A total of 246 clinically apparent findings were identified in 169 asymptomatic participants (32.9% of participants who completed a CT scan). Another 245 participants (48%) had findings of unknown significance, a total of 307 findings. At least 4 cases in this study led to a clinically significant intervention. Conclusion Although CT scans were completed for research purposes, study procedures resulted in the diagnosis and treatment of individuals who were previously asymptomatic. Potential clinical benefits in imaging research are moderated by considerations regarding possible harm and costs resulting from uncertain findings and the use of CT scans for nonclinical purposes. The continued development of protocols for the handling of incidental findings in research and the establishment of guidelines are needed to ensure that research procedures mirror the best interests of participants. PMID:24808109

Espinoza, Anna; Malone, Kendra; Balyakina, Elizabeth; Fulda, Kimberly G.; Cardarelli, Roberto

2014-01-01

200

Pupils' Perceptions of Foreign Language Learning in the Primary School--Findings from the Key Stage 2 Language Learning Pathfinder Evaluation  

ERIC Educational Resources Information Center

This article presents findings on pupil attitudes towards learning foreign languages in Key Stage 2 (ages 7-11) in primary schools in England. As a consequence of the National Languages Strategy, the University of Warwick was commissioned by the then Department for Education and Skills to undertake an evaluation between 2003 and 2005 of 19…

Martin, Cynthia

2012-01-01

201

Monitoring the Future: National Results on Adolescent Drug Use. Overview of Key Findings, 2009. NIH Publication No. 10-7583  

ERIC Educational Resources Information Center

Monitoring the Future (MTF) is a long-term study of American adolescents, college students, and adults through age 50. It has been conducted annually by the University of Michigan's Institute for Social Research since its inception in 1975. It is supported under a series of investigator-initiated, competing research grants from the National…

Johnston, Lloyd D.; O'Malley, Patrick M.; Bachman, Jerald G.; Schulenberg, John E.

2010-01-01

202

Integrating findings of traditional medicine with modern pharmaceutical research: the potential role of linked open data  

Microsoft Academic Search

One of the biggest obstacles to progress in modern pharmaceutical research is the difficulty of integrating all available research findings into effective therapies for humans. Studies of traditionally used pharmacologically active plants and other substances in traditional medicines may be valuable sources of previously unknown compounds with therapeutic actions. However, the integration of findings from traditional medicines can be fraught

Matthias Samwald; Michel Dumontier; Jun Zhao; Joanne S Luciano; Michael Scott Marshall; Kei Cheung

2010-01-01

203

Money for Research, Not Energy Bills: Finding Energy and Cost Savings in  

E-print Network

, to meet national security, materials design, climate protection, and energy goals, among othersLBNL-4282E Money for Research, Not Energy Bills: Finding Energy and Cost Savings in High of California. #12;1 Money for Research, Not for Energy Bills: Finding Energy and Cost Savings in High

204

Impact of problem finding on the quality of authentic open inquiry science research projects  

Microsoft Academic Search

Problem finding is a creative process whereby individuals develop original ideas for study. Secondary science students who successfully participate in authentic, novel, open inquiry studies must engage in problem finding to determine viable and suitable topics. This study examined problem finding strategies employed by students who successfully completed and presented the results of their open inquiry research at the 2007

Frank Labanca

2008-01-01

205

Top 10 Greatest "Hits": Important Findings and Future Directions for Intimate Partner Violence Research  

ERIC Educational Resources Information Center

In this article, the author highlights her choice of the 10 most important recent findings from the intimate partner violence research literature, which include (a) the creation of the Conflict Tactics Scale; (b) the finding that violent acts are most often perpetrated by intimates; (c) a series of findings that indicate that women also engage in…

Langhinrichsen-Rohling, Jennifer

2005-01-01

206

Racial and Ethnic Disparities: Key Findings from the National Survey of America's Families. Series B, No. B-5.  

ERIC Educational Resources Information Center

This brief outlines findings from the National Survey of America's Families, a survey of 44,461 households, on 7 indicators of well-being by race and ethnicity: poverty, family structure, child support, food hardship, housing hardship, health status, and health insurance coverage. For the purpose of this brief, all persons of Hispanic origin were…

Staveteig, Sarah; Wigton, Alyssa

207

Enhancing the Interpretation of "Significant" Findings: The Role of Mixed Methods Research  

ERIC Educational Resources Information Center

The present essay outlines how mixed methods research can be used to enhance the interpretation of significant findings. First, we define what we mean by significance in educational evaluation research. With regard to quantitative-based research, we define the four types of significance: statistical significance, practical significance, clinical…

Onwuegbuzie, Anthony J.; Leech, Nancy L.

2004-01-01

208

Research off Limits and Underground: Street Corner Methods for Finding Invisible Students  

ERIC Educational Resources Information Center

This paper investigates research methods for studies of school drop-outs and push-outs, populations that are very difficult to find since they no longer have an institutional affiliation. The work argues that street corner research, which was in favor among the early urban researchers of the Chicago school, may have a renewed role in these…

Simmons, Lizbet

2007-01-01

209

Comparative Study of Human and Mouse Postsynaptic Proteomes Finds High Compositional Conservation and Abundance Differences for Key Synaptic Proteins  

PubMed Central

Direct comparison of protein components from human and mouse excitatory synapses is important for determining the suitability of mice as models of human brain disease and to understand the evolution of the mammalian brain. The postsynaptic density is a highly complex set of proteins organized into molecular networks that play a central role in behavior and disease. We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461. A large compositional overlap was observed; more than 70% of human postsynaptic density proteins were also observed in the mouse postsynaptic density. Quantitative analysis of postsynaptic density components in both species indicates a broadly similar profile of abundance but also shows that there is higher abundance variation between species than within species. Well known components of this synaptic structure are generally more abundant in the mouse postsynaptic density. Significant inter-species abundance differences exist in some families of key postsynaptic density proteins including glutamatergic neurotransmitter receptors and adaptor proteins. Furthermore, we have identified a closely interacting set of molecules enriched in the human postsynaptic density that could be involved in dendrite and spine structural plasticity. Understanding synapse proteome diversity within and between species will be important to further our understanding of brain complexity and disease. PMID:23071613

Bayes, Alex; Collins, Mark O.; Croning, Mike D. R.; van de Lagemaat, Louie N.; Choudhary, Jyoti S.; Grant, Seth G. N.

2012-01-01

210

Tulane Family Planning Operations Research in the English Speaking Caribbean: Final Research Findings.  

National Technical Information Service (NTIS)

Operations research in the area of family planning has proved useful in identifying barriers to contraceptive use, resolving these problems, and testing new approaches to service delivery. The results of operations research in six English-speaking Caribbe...

J. T. Bertrand, P. Russell-Brown, E. Landry

1986-01-01

211

Becoming a Scientist: Research Findings on STEM Students' Gains from Conducting Undergraduate Research  

Microsoft Academic Search

Undergraduate research is widely believed to enhance STEM students' education and increase their persistence to graduate education and careers in the sciences. Yet until very recently, little evidence from research and evaluation studies was available to substantiate such claims and document what students gain from doing undergraduate research or how these gains come about. We have conducted a three-year qualitative

A. Hunter; S. Laursen; H. Thiry; E. Seymour

2006-01-01

212

Small is useful in endocrine disrupter assessment--four key recommendations for aquatic invertebrate research.  

PubMed

As we enter the 21st "biocentury", with issues such as biodiversity and biotechnology growing in public profile, it is important to reflect on the immense ecological, medical and economic importance of invertebrates. Efforts to understand the diverse biology of invertebrates come from many directions, including Nobel Prize winning developmental biology, research to control insects that threaten human health and food supplies, aquaculture opportunities and also within ecotoxicology. In the latter context, this special journal volume highlights the importance of addressing endocrine disruption in aquatic invertebrates, from molecular and cellular biomarkers to population-relevant adverse effects. The contributors to this special volume have provided an excellent assessment of both the fundamental endocrinology and applied ecotoxicology of many aquatic invertebrate groups. On the premise that reproductive success is ultimately the vital population parameter, this chapter gives a personal view of key gaps in knowledge in invertebrate reproductive and developmental endocrinology and ecotoxicology. Based on current knowledge, there are four key issues that need to be prioritised within aquatic ecotoxicology: (1) a wider assessment of the reproductive status of invertebrates in both freshwater and coastal ecosystems; (2) prioritisation of laboratory studies in OECD and other regulatory test organisms, including basic endocrinology and ADME (absorption, distribution, metabolism and excretion) research; (3) development and validation of mechanistic biomarkers that can be used as "signposts" to help prioritise species and chronic test endpoint selection, and help link data from laboratory and field studies; and (4) develop a comparative invertebrate toxicology database utilising the prioritised reference chemicals from the EDIETA workshop, encompassing the diverse modes-of-action pertinent to endocrine disrupter testing in both aquatic arthropod and non-arthropod invertebrates. PMID:17219089

Hutchinson, Thomas H

2007-02-01

213

The key-role of instrumentation for the new generation of research reactors  

SciTech Connect

Experimental reactors have been indispensable since the beginning of the use of nuclear energy to support many important fields of industry and research: safety, lifetime management and operation optimisation of nuclear power plants, development of new types of reactors with improved resources and fuel cycle management, medical applications, material development for fusion... Over the last decade, modifications of the operational needs and the ageing of the nuclear facilities have led to several closures and time is coming for new key European Experimental Reactors (EER) within a European and International Framework. Projects like MYRRHA and JHR are underway to define and implement a new consistent EER policy: - Meeting industry and public needs, keeping a high level of scientific expertise; - With a limited number of EER, specified within a rational compromise between specialisation, complementarities and back-up capacities; - To be put into effective operation in this or the next decade. These new projects will give to the scientific community high performances allowing innovative fields of R and D. A new generation of instrumentation to address new phenomena and that allows better on-line investigation of some key physical parameters is necessary to achieve these challenges. One initiative to progress in this direction is the Joint Instrumentation Laboratory between CEA and SCK.CEN which has already given significant results and patents. Major scientific challenges to achieve in the field of instrumentation for this new generation of European Research Reactors have to be investigated and are described in this paper as well as a short description of the JHR and MYRRHA reactors that will be serving as flexible irradiation facilities for testing them. (authors)

Bignan, G.; Villard, J. F.; Destouches, C. [CEA Cadarache Research Centre (France); Baeten, P.; Vermeeren, L.; Michiels, S. [SCK.CEN Mol Research Centre (Belgium)

2011-07-01

214

On norms and bodies: findings from field research on cosmetic surgery in Rio de Janeiro, Brazil  

Microsoft Academic Search

Brazil has the second highest rate of cosmetic surgery worldwide, provided in a large number of public and private clinics and hospitals, especially in the southeast. This qualitative field research in Rio de Janeiro included participant observation and in-depth interviews with 18 women cosmetic surgery patients, 10 key informants (e.g. psychologists and sociologists) and 12 plastic surgeons. Fifteen of the

Daniela Dorneles de Andrade

2010-01-01

215

U of Pittsburgh researchers find stem cells in mice in the esophagus  

Cancer.gov

In an animal study published online today in Cell Reports, researchers report findings from mice that could lead to new insights into the development and treatment of esophageal cancer and the precancerous condition known as Barrett's esophagus.

216

Niacin Doesn't Reduce Heart Problems, May Create Some, Research Finds  

MedlinePLUS

... on this page, please enable JavaScript. Niacin Doesn't Reduce Heart Problems, May Create Some, Research Finds ... News) -- Niacin, a commonly used cholesterol treatment, doesn't reduce the risk of heart attack or stroke ...

217

U of Minnesota researchers find that microRNA is tied to colon cancer tumor growth  

Cancer.gov

Researchers have identified microRNAs that may cause colon polyps from turning cancerous. The finding could help physicians provide more specialized, and earlier, treatment before colon cancer develops.

218

Alcohol Use Disorders, Research Findings | NIH MedlinePlus the Magazine  

MedlinePLUS

... of this page please turn Javascript on. Feature: Alcohol Use and Abuse Alcohol Use Research Findings Past Issues / Winter 2013 Table ... and adolescents years after they were exposed to alcohol in the womb. That is according to a ...

219

Using Research Findings to Change School and Classroom Practices: Results of an Experimental Study  

Microsoft Academic Search

A quasi-experimental, treatment-control group investigation was designed to test the effects of introducing research findings from effective teaching and school leadership into ongoing school settings. Research findings were translated into observable staff developer and teacher behaviors. Following 5 days of training 3 weeks prior to the beginning of school, treatment staff developers implemented self-designed plans to increase effective teaching behaviors.

Gary A. Griffin; Susan Barnes

1986-01-01

220

School Effectiveness Research Findings in the Portuguese Speaking Countries: Brazil and Portugal  

ERIC Educational Resources Information Center

This paper provides findings of research on school effectiveness and discusses implications for evaluation in Brazil and Portugal. Most findings reported over the last decade have been published in Brazilian or Portuguese refereed journals. Thus, a brief literature review of such studies enables that knowledge to reach international scholars and…

Ferrão, Maria Eugénia

2014-01-01

221

Published: 24 hours ago New research finds people and pigeons see eye to eye  

E-print Network

Published: 24 hours ago New research finds people and pigeons see eye to eye A pigeon in flight. Credit: Robin Freeman. Pigeons and humans use similar visual cues to identify objects, a finding. Gibson and his colleagues found that humans and pigeons, which have different visual systems, have

Gosselin, Frédéric

222

Key findings from the first 360 sols of the Curiosity rover mission in Gale crater, Mars (Invited)  

NASA Astrophysics Data System (ADS)

The goal of the Curiosity rover mission is to search for habitable environments. Since its landing in Gale crater early August 2012, the Curiosity rover has been exploring primarily the area in vicinity of where it landed and 450 m to the east in the Glenelg region. Measurements of energetic particle radiation during the cruise to Mars and on the martian surface reveal the effects of shielding by spacecraft materials and Mars' variable atmosphere. The unique setting of Curiosity within a deep and large crater has allowed its meteorological instruments to capture phenomena not accessible to other missions. Atmospheric volume mixing and isotope ratios point to significant loss from the top of the martian atmosphere, supportive of early conditions on Mars being more suitable for life. Geologic mapping using orbital data sets provided regional context that was used by the science team to plan where the rover should go and to interpret the findings. The most intensive geologic investigations included the study of conglomeratic sediments deposited by sustained stream flow; highly alkaline igneous rocks and minerals that expand the range of known volcanic compositions on Mars; correlations between hydration signatures and geologic features; a basaltic aeolian sand shadow that records an environment with low water activity; and a smectite-rich relatively higher thermal inertia mudstone that records an ancient, habitable environment of shallow lake waters with low salinity, neutral acidity, and variable but not strongly oxidizing conditions. The rover has begun a several-kilometer drive to Aeolis Mons (informally known as Mount Sharp), where close-up examination of a thick succession of layered deposits is expected to reveal information about the evolution of past environmental conditions on Mars, from the study of older clay-bearing to younger hydrated-sulfate-bearing deposits.

Crisp, J. A.; Grotzinger, J. P.; Vasavada, A. R.; Team, M.

2013-12-01

223

Researchers Find that Tumor Stem Cells are Good Models for Brain Tumor Research  

Cancer.gov

Researchers have found that tumor stem cell lines derived directly from human glioblastoma brain tumors are a better model to study the biology and physiology of glioblastomas than are cancer cell lines that have been commonly used in cancer research laboratories.

224

FRESHWATER FINDINGS, 1979-1982: RESEARCH PUBLICATIONS OF THE ENVIRONMENTAL RESEARCH LABORATORY, DULUTH, MINNESOTA  

EPA Science Inventory

This report contains citations of publications for the years 1979-1982 on research conducted or supported by the Environmental Research Laboratory-Duluth. All published material has been organized into two major categories: (1) Journal Articles, Book Chapters, Proceedings, etc., ...

225

'Geo'chemical research: a key building block for nuclear waste disposal safety cases.  

PubMed

Disposal of high level radioactive waste in deep underground repositories has been chosen as solution by several countries. Because of the special status this type waste has in the public mind, national implementation programs typically mobilize massive R&D efforts, last decades and are subject to extremely detailed and critical social-political scrutiny. The culminating argument of each program is a 'Safety Case' for a specific disposal concept containing, among other elements, the results of performance assessment simulations whose object is to model the release of radionuclides to the biosphere. Public and political confidence in performance assessment results (which generally show that radionuclide release will always be at acceptable levels) is based on their confidence in the quality of the scientific understanding in the processes included in the performance assessment model, in particular those governing radionuclide speciation and mass transport in the geological host formation. Geochemistry constitutes a core area of research in this regard. Clay-mineral rich formations are the subjects of advanced radwaste programs in several countries (France, Belgium, Switzerland...), principally because of their very low permeabilities and demonstrated capacities to retard by sorption most radionuclides. Among the key processes which must be represented in performance assessment models are (i) radioelement speciation (redox state, speciation, reactions determining radionuclide solid-solution partitioning) and (ii) diffusion-driven transport. The safety case must therefore demonstrate a detailed understanding of the physical-chemical phenomena governing the effects of these two aspects, for each radionuclide, within the geological barrier system. A wide range of coordinated (and internationally collaborated) research has been, and is being, carried out in order to gain the detailed scientific understanding needed for constructing those parts of the Safety Case supporting how radionuclide transfer is represented in the performance assessment model. The objective here is to illustrate how geochemical research contributes to this process and, above all, to identify a certain number of subjects which should be treated in priority. PMID:19008019

Altmann, Scott

2008-12-12

226

Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science  

PubMed Central

Background Many interventions found to be effective in health services research studies fail to translate into meaningful patient care outcomes across multiple contexts. Health services researchers recognize the need to evaluate not only summative outcomes but also formative outcomes to assess the extent to which implementation is effective in a specific setting, prolongs sustainability, and promotes dissemination into other settings. Many implementation theories have been published to help promote effective implementation. However, they overlap considerably in the constructs included in individual theories, and a comparison of theories reveals that each is missing important constructs included in other theories. In addition, terminology and definitions are not consistent across theories. We describe the Consolidated Framework For Implementation Research (CFIR) that offers an overarching typology to promote implementation theory development and verification about what works where and why across multiple contexts. Methods We used a snowball sampling approach to identify published theories that were evaluated to identify constructs based on strength of conceptual or empirical support for influence on implementation, consistency in definitions, alignment with our own findings, and potential for measurement. We combined constructs across published theories that had different labels but were redundant or overlapping in definition, and we parsed apart constructs that conflated underlying concepts. Results The CFIR is composed of five major domains: intervention characteristics, outer setting, inner setting, characteristics of the individuals involved, and the process of implementation. Eight constructs were identified related to the intervention (e.g., evidence strength and quality), four constructs were identified related to outer setting (e.g., patient needs and resources), 12 constructs were identified related to inner setting (e.g., culture, leadership engagement), five constructs were identified related to individual characteristics, and eight constructs were identified related to process (e.g., plan, evaluate, and reflect). We present explicit definitions for each construct. Conclusion The CFIR provides a pragmatic structure for approaching complex, interacting, multi-level, and transient states of constructs in the real world by embracing, consolidating, and unifying key constructs from published implementation theories. It can be used to guide formative evaluations and build the implementation knowledge base across multiple studies and settings. PMID:19664226

Damschroder, Laura J; Aron, David C; Keith, Rosalind E; Kirsh, Susan R; Alexander, Jeffery A; Lowery, Julie C

2009-01-01

227

Print Article Email Article DentalPlans.com > Dental Health Articles > Science > New Research Finds People  

E-print Network

People New Research Finds People And Pigeons See Eye To Eye Updated: 2/24/2007 5:31:19 AM 2007 Investment led to the development of flying robots and unmanned helicopters," the researchers say. So a software engineer who wants to design a program to help a robot recognize objects can get a leg up from evolution

Gosselin, Frédéric

228

Technology to Support Writing by Students with Learning and Academic Disabilities: Recent Research Trends and Findings  

ERIC Educational Resources Information Center

The trends and findings from a descriptive analysis of 25 years of research studies examining the effectiveness of technology to support the compositional writing of students with learning and academic disabilities are presented. A corpus of 85 applied research studies of writing technology effectiveness was identified from among 249 items in the…

Peterson-Karlan, George R.

2011-01-01

229

Disseminating research findings: what should researchers do? A systematic scoping review of conceptual frameworks  

PubMed Central

Background Addressing deficiencies in the dissemination and transfer of research-based knowledge into routine clinical practice is high on the policy agenda both in the UK and internationally. However, there is lack of clarity between funding agencies as to what represents dissemination. Moreover, the expectations and guidance provided to researchers vary from one agency to another. Against this background, we performed a systematic scoping to identify and describe any conceptual/organising frameworks that could be used by researchers to guide their dissemination activity. Methods We searched twelve electronic databases (including MEDLINE, EMBASE, CINAHL, and PsycINFO), the reference lists of included studies and of individual funding agency websites to identify potential studies for inclusion. To be included, papers had to present an explicit framework or plan either designed for use by researchers or that could be used to guide dissemination activity. Papers which mentioned dissemination (but did not provide any detail) in the context of a wider knowledge translation framework, were excluded. References were screened independently by at least two reviewers; disagreements were resolved by discussion. For each included paper, the source, the date of publication, a description of the main elements of the framework, and whether there was any implicit/explicit reference to theory were extracted. A narrative synthesis was undertaken. Results Thirty-three frameworks met our inclusion criteria, 20 of which were designed to be used by researchers to guide their dissemination activities. Twenty-eight included frameworks were underpinned at least in part by one or more of three different theoretical approaches, namely persuasive communication, diffusion of innovations theory, and social marketing. Conclusions There are currently a number of theoretically-informed frameworks available to researchers that can be used to help guide their dissemination planning and activity. Given the current emphasis on enhancing the uptake of knowledge about the effects of interventions into routine practice, funders could consider encouraging researchers to adopt a theoretically-informed approach to their research dissemination. PMID:21092164

2010-01-01

230

Models of consent to return of incidental findings in genomic research.  

PubMed

Genomic research-including whole genome sequencing and whole exome sequencing-has a growing presence in contemporary biomedical investigation. The capacity of sequencing techniques to generate results that go beyond the primary aims of the research-historically referred to as "incidental findings"-has generated considerable discussion as to how this information should be handled-that is, whether incidental results should be returned, and if so, which ones.Federal regulations governing most human subjects research in the United States require the disclosure of "the procedures to be followed" in the research as part of the informed consent process. It seems reasonable to assume-and indeed, many commentators have concluded-that genomic investigators will be expected to inform participants about, among other procedures, the prospect that incidental findings will become available and the mechanisms for dealing with them. Investigators, most of whom will not have dealt with these issues before, will face considerable challenges in framing meaningful disclosures for research participants.To help in this task, we undertook to identify the elements that should be included in the informed consent process related to incidental findings. We did this by surveying a large number of genomic researchers (n = 241) and by conducting in-depth interviews with a smaller number of researchers (n = 28) and genomic research participants (n = 20). Based on these findings, it seems clear to us that routine approaches to informed consent are not likely to be effective in genomic research in which the prospect of incidental findings exists. Ensuring that participants' decisions are informed and meaningful will require innovative approaches to dealing with the consent issue. We have identified four prototypical models of a consent process for return of incidental findings. PMID:24919982

Appelbaum, Paul S; Parens, Erik; Waldman, Cameron R; Klitzman, Robert; Fyer, Abby; Martinez, Josue; Price, W Nicholson; Chung, Wendy K

2014-01-01

231

Disclosing incidental findings in genetics contexts: a review of the empirical ethical research.  

PubMed

The disclosure of incidental findings, also called unsolicited findings, unexpected results, and secondary variants, is increasingly recognised as an issue in clinical and research genetics contexts. The rise of next generation sequencing methods has only intensified the issue, increasing the likelihood of incidental findings appearing. This review focuses on empirical research on the ethical issues involved. Electronic databases were searched for articles covering quantitative and qualitative research on the ethical issues involved in the disclosure of incidental findings in clinical and research genetics contexts. 16 articles were ultimately accepted for review. Data was extracted and synthesised on the factors that should be taken into account during the decision-making process surrounding the disclosure of an incidental finding in a genetics context. These factors include the possibility of disclosure, various practical and technical factors, and various ethical factors. We suggest the development of a decision-making tree, involving an exploration of the practical and ethical concerns raised by the studies. This is in our view the best way of handling the wide variety of both possible incidental findings and parties interested in the disclosure of incidental findings. PMID:24036277

Christenhusz, Gabrielle M; Devriendt, Koenraad; Dierickx, Kris

2013-10-01

232

Key trends in interprofessional research: a macrosociological analysis from 1970 to 2010.  

PubMed

The field of interprofessional research has grown both in size and in importance since the 1970s. In this paper, we use a macrosociological approach and a Bourdieusian theoretical framework to investigate this growth and the changing nature of the field's research. We investigate publication trends at the aggregate (field) level, using an original dataset of 100,488 interprofessional-related articles published between 1970 and 2010 and recorded in the PubMed database. Articles were coded using a list of 638 codes that were then analyzed thematically and longitudinally. Our results are presented in two main sections. Initially, we consider the growth and reach of the interprofessional field. Second, we explore the five different trends ("terminological issues", "rising management rhetoric", "expansion of psychometrics", "shift from individualism to collectivism" and "emerging issues") that emerged out of our thematic analysis of publications over time. These findings are discussed in the light of Bourdieu's framework to provide an indication of what we argue is a growing legitimacy of the field of interprofessional research as a scholarly domain in its own right. PMID:22967222

Paradis, Elise; Reeves, Scott

2013-03-01

233

[Research on the method of stress assessment--from the research findings of 2010].  

PubMed

The Japanese Society for Occupational Mental Health has conducted research on assessment of the psychological load (i.e., stress) among workers. Investigations were conducted three times, and those were contract research projects assigned by the Ministry of Health, Labour and Welfare. In this project, the author was the primary researcher. In the latest research, a survey utilizing the Live Event Method was performed extensively nationwide; the survey covered 10,494 subjects (including 1,977 females) from all types of industry and occupation. The objective of this research was to reevaluate the Psychological Load Assessment Sheet used as an evaluation basis for the "Certification of workers' compensation related to mental disorders from psychological load." Two previous research investigations, conducted in 2002 and 2006, had suggested the need for such reevaluation. The outcomes revealed that, the longer the monthly overtime working hours, the higher the stress scores (in the range of 0 to 10), and the lower the appearance rate of stress. Subjects who performed 140 hours or more of overtime work per month, which fell under the category of "Extremely Excessive Overtime Work," showed 6.3 points, which was markedly high, and ranked fourth in the survey with 63 assessment items. The category, "Extremely Excessive Overtime Work," includes two working hour ranges, 120 hours or more and 160 hours or more; those working hour ranges were defined in the revision based on the latest research. Monthly overtime work of 120 hours or more, but less than 140 hours, was ranked ninth and scored 6.3 points. Monthly overtime work of 80 hours or more, but less than 100 hours, scored 5.3 points with a frequency of 14.2%. Based on the above results, new assessment items were added to the Psychological Load Assessment Sheet. This paper addresses and studies the issues explained above. PMID:23346811

Natsume, Makoto

2012-01-01

234

Research and Teaching: An Investigation of the Evolution of High School and Undergraduate Student Researchers' Understanding of Key Science Ethics Concepts  

ERIC Educational Resources Information Center

High school and undergraduate research students were surveyed over the 10-week period of their summer research programs to investigate their understanding of key concepts in science ethics and whether their understanding changed over the course of their summer research experiences. Most of the students appeared to understand the issues relevant to…

Mabrouk, Patricia Ann

2013-01-01

235

Research education: findings of a study of teaching-learning research using multiple analytical perspectives.  

PubMed

This multimethod, qualitative study provides results for educators of nursing doctoral students to consider. Combining the expertise of an empirical analytical researcher (who uses statistical methods) and an interpretive phenomenological researcher (who uses hermeneutic methods), a course was designed that would place doctoral students in the midst of multiparadigmatic discussions while learning fundamental research methods. Field notes and iterative analytical discussions led to patterns and themes that highlight the value of this innovative pedagogical application. Using content analysis and interpretive phenomenological approaches, together with one of the students, data were analyzed from field notes recorded in real time over the period the course was offered. This article describes the course and the study analysis, and offers the pedagogical experience as transformative. A link to a sample syllabus is included in the article. The results encourage nurse educators of doctoral nursing students to focus educational practice on multiple methodological perspectives. [J Nurs Educ. 2014;53(12):673-677.]. PMID:25406843

Vandermause, Roxanne; Barbosa-Leiker, Celestina; Fritz, Roschelle

2014-12-01

236

DIII-D research towards resolving key issues for ITER and steady-state tokamaks  

NASA Astrophysics Data System (ADS)

The DIII-D research program is addressing key ITER research needs and developing the physics basis for future steady-state tokamaks. Pellet pacing edge-localized mode (ELM) control in the ITER configuration reduces ELM energy loss in proportion to 1/fpellet by inducing ELMs at up to 12× the natural ELM rate. Complete suppression of ELMs with resonant magnetic perturbations has been extended to the q95 expected for ITER baseline scenario discharges, and long-duration ELM-free QH-mode discharges have been produced with ITER-relevant co-current neutral-beam injection (NBI) using external n = 3 coils to generate sufficient counter-Ip torque. ITER baseline discharges at ?N ˜ 2 and scaled NBI torque have been maintained in stationary conditions for more than four resistive times using electron cyclotron current drive (ECCD) for tearing mode suppression and disruption avoidance; active tracking with steerable launchers and feedback control catch these modes at small amplitude, reducing the ECCD power required to suppress them. Massive high-Z gas injection into disruption-induced 300-600 kA 20 MeV runaway electron (RE) beams yield dissipation rates ˜10× faster than expected from e-e collisions and demonstrate the possibility of benign dissipation of such REs should they occur in ITER. Other ITER-related experiments show measured intrinsic plasma torque in good agreement with a physics-based model over a wide range of conditions, while first-time main-ion rotation measurements show it to be lower than expected from neoclassical theory. Core turbulence measurements show increased temperature fluctuations correlated with sharply enhanced electron transport when \

Hill, D. N.; the DIII-D Team

2013-10-01

237

Key Topics for High-Lift Research: A Joint Wind Tunnel/Flight Test Approach  

NASA Technical Reports Server (NTRS)

Future high-lift systems must achieve improved aerodynamic performance with simpler designs that involve fewer elements and reduced maintenance costs. To expeditiously achieve this, reliable CFD design tools are required. The development of useful CFD-based design tools for high lift systems requires increased attention to unresolved flow physics issues. The complex flow field over any multi-element airfoil may be broken down into certain generic component flows which are termed high-lift building block flows. In this report a broad spectrum of key flow field physics issues relevant to the design of improved high lift systems are considered. It is demonstrated that in-flight experiments utilizing the NASA Dryden Flight Test Fixture (which is essentially an instrumented ventral fin) carried on an F-15B support aircraft can provide a novel and cost effective method by which both Reynolds and Mach number effects associated with specific high lift building block flows can be investigated. These in-flight high lift building block flow experiments are most effective when performed in conjunction with coordinated ground based wind tunnel experiments in low speed facilities. For illustrative purposes three specific examples of in-flight high lift building block flow experiments capable of yielding a high payoff are described. The report concludes with a description of a joint wind tunnel/flight test approach to high lift aerodynamics research.

Fisher, David; Thomas, Flint O.; Nelson, Robert C.

1996-01-01

238

Nutrition and Growth: Recent Research Findings and Research Priorities. Matrix No. 3.  

ERIC Educational Resources Information Center

Recent research indicates that low income adults and infants in the United States are more likely to be overweight than undernourished. Very possibly, the assumptions upon which food supplement programs are based are ill-founded. While many of the currently operating broadly conceived supplemental food programs achieve desirable collateral…

Graham, George G.

239

Reconciling incongruous qualitative and quantitative findings in mixed methods research: exemplars from research with drug using populations  

PubMed Central

Mixed methods research is increasingly being promoted in the health sciences as a way to gain more comprehensive understandings of how social processes and individual behaviours shape human health. Mixed methods research most commonly combines qualitative and quantitative data collection and analysis strategies. Often, integrating findings from multiple methods is assumed to confirm or validate the findings from one method with the findings from another, seeking convergence or agreement between methods. Cases in which findings from different methods are congruous are generally thought of as ideal, while conflicting findings may, at first glance, appear problematic. However, the latter situation provides the opportunity for a process through which apparently discordant results are reconciled, potentially leading to new emergent understandings of complex social phenomena. This paper presents three case studies drawn from the authors’ research on HIV risk among injection drug users in which mixed methods studies yielded apparently discrepant results. We use these case studies (involving injection drug users [IDUs] using a needle/syringe exchange program in Los Angeles, California, USA; IDUs seeking to purchase needle/syringes at pharmacies in Tijuana, Mexico; and young street-based IDUs in San Francisco, CA, USA) to identify challenges associated with integrating findings from mixed methods projects, summarize lessons learned, and make recommendations for how to more successfully anticipate and manage the integration of findings. Despite the challenges inherent in reconciling apparently conflicting findings from qualitative and quantitative approaches, in keeping with others who have argued in favour of integrating mixed methods findings, we contend that such an undertaking has the potential to yield benefits that emerge only through the struggle to reconcile discrepant results and may provide a sum that is greater than the individual qualitative and quantitative parts. PMID:21680168

Wagner, Karla D.; Davidson, Peter J.; Pollini, Robin A.; Strathdee, Steffanie A.; Washburn, Rachel; Palinkas, Lawrence A.

2011-01-01

240

Do Disadvantaged Students Get Less Effective Teaching? Key Findings from Recent Institute of Education Sciences Studies. NCEE Evaluation Brief. NCEE 2014-4010  

ERIC Educational Resources Information Center

Lack of researcher consensus on how to measure disadvantaged students' access to effective teaching has made it challenging for practitioners to draw lessons from the data. This brief aims to help policymakers understand the emerging evidence by synthesizing findings from three peer-reviewed studies that collectively span 17 states. The…

Max, Jeffrey; Glazerman, Steven

2014-01-01

241

Findings from the National Institute of Nursing research related to neonatal care: 2005 update.  

PubMed

This annotated bibliography from the National Institute of Nursing Research (NINR) presents recent findings on a variety of studies related to prenatal conditions and the benefits of prenatal care, advances in our understanding about infant care and family issues in the newborn intensive care unit (NICU), and the importance of clinicians in supporting and communicating with the family. By sharing this bibliography, we hope to increase the awareness of these valuable research findings within the nursing community and support the continued development of evidence-based practice in antenatal, postpartum, and neonatal care. PMID:16383185

2005-01-01

242

Translating research findings to promote peace: moving from "field to forum" with verbatim theatre.  

PubMed

Peace, both personal and global, resides in understanding. Verbatim theatre is introduced as a vehicle for translating research findings to promote understanding and thereby, promote health. By shifting our translation lens from "bench to bedside" to "field to forum," new opportunities arise for moving nursing research-findings to an engaged audience. Stories from Pearl Harbor and Hiroshima survivors were woven into the verbatim performance, With Their Voices Raised. Analysis of audience members' reflections after the performance suggests that verbatim theatre created a connection based in openness, engagement, and trust that informed understanding and raised awareness about peace processes. PMID:23907299

Liehr, Patricia; Morris, Kate; Leavitt, Mary Ann; Takahashi, Ryutaro

2013-01-01

243

Managing clinically significant findings in research: the UK10K example  

PubMed Central

Recent advances in sequencing technology allow data on the human genome to be generated more quickly and in greater detail than ever before. Such detail includes findings that may be of significance to the health of the research participant involved. Although research studies generally do not feed back information on clinically significant findings (CSFs) to participants, this stance is increasingly being questioned. There may be difficulties and risks in feeding clinically significant information back to research participants, however, the UK10K consortium sought to address these by creating a detailed management pathway. This was not intended to create any obligation upon the researchers to feed back any CSFs they discovered. Instead, it provides a mechanism to ensure that any such findings can be passed on to the participant where appropriate. This paper describes this mechanism and the specific criteria, which must be fulfilled in order for a finding and participant to qualify for feedback. This mechanism could be used by future research consortia, and may also assist in the development of sound principles for dealing with CSFs. PMID:24424120

Kaye, Jane; Hurles, Matthew; Griffin, Heather; Grewal, Jasote; Bobrow, Martin; Timpson, Nic; Smee, Carol; Bolton, Patrick; Durbin, Richard; Dyke, Stephanie; Fitzpatrick, David; Kennedy, Karen; Kent, Alastair; Muddyman, Dawn; Muntoni, Francesco; Raymond, Lucy F; Semple, Robert; Spector, Tim

2014-01-01

244

Mont Terri Underground Rock Laboratory, Switzerland-Research Program And Key Results  

NASA Astrophysics Data System (ADS)

Argillaceous formations generally act as aquitards because of their low hydraulic conductivities. This property, together with the large retention capacity of clays for cationic contaminants and the potential for self-sealing, has brought clay formations into focus as potential host rocks for the geological disposal of radioactive waste. Excavated in the Opalinus Clay formation, the Mont Terri underground rock laboratory in the Jura Mountains of NW Switzerland is an important international test site for researching clay formations. Research is carried out in the underground facility, which is located adjacent to the security gallery of the Mont Terri motorway tunnel. Fifteen partners from European countries, USA, Canada and Japan participate in the project. The objectives of the research program are to analyze the hydrogeological, geochemical and rock mechanical properties of the Opalinus Clay, to determine the changes induced by the excavation of galleries and by heating of the rock formation, to test sealing and container emplacement techniques and to evaluate and improve suitable investigation techniques. For the safety of deep geological disposal, it is of key importance to understand the processes occurring in the undisturbed argillaceous environment, as well as the processes in a disturbed system, during the operation of the repository. The objectives are related to: 1. Understanding processes and mechanisms in undisturbed clays and 2. Experiments related to repository-induced perturbations. Experiments of the first group are dedicated to: i) Improvement of drilling and excavation technologies and sampling methods; ii) Estimation of hydrogeological, rock mechanical and geochemical parameters of the undisturbed Opalinus Clay. Upscaling of parameters from laboratory to in situ scale; iii) Geochemistry of porewater and natural gases; evolution of porewater over time scales; iv) Assessment of long-term hydraulic transients associated with erosion and thermal scenarios and v) Evaluation of diffusion and retention parameters for long-lived radionuclides. Experiments related to repository-induced perturbations are focused on: i) Influence of rock liner on the disposal system and the buffering potential of the host rock; ii) Self-sealing processes in the excavation damaged zone; iii) Hydro-mechanical coupled processes (e.g. stress redistributions and pore pressure evolution during excavation); iv) Thermo-hydro-mechanical-chemical coupled processes (e.g. heating of bentonite and host rock) and v) Gas-induced transport of radionuclides in porewater and along interfaces in the engineered barrier system. A third research direction is to demonstrate the feasibility of repository construction and long-term safety after repository closure. Demonstration experiments can contribute to improving the reliability of the scientific basis for the safety assessment of future geological repositories, particularly if they are performed on a large scale and with a long duration. These experiments include the construction and installation of engineered barriers on a 1:1 scale: i) Horizontal emplacement of canisters; ii) Evaluation of the corrosion of container materials; repository re-saturation; iii) Sealing of boreholes and repository access tunnels and iv) Long-term monitoring of the repository. References Bossart, P. & Thury, M. (2008): Mont Terri Rock Laboratory. Project, Programme 1996 to 2007 and Results. - Rep. Swiss Geol. Surv. 3.

Nussbaum, C. O.; Bossart, P. J.

2012-12-01

245

Researchers Find Genetic Response to Global Warming: Changing Climate Prompts Genetic Change in Squirrels  

NSDL National Science Digital Library

University of Alberta biologist Stan Boutin and his research team have recently published findings that North American red squirrels exhibit genetic changes in response to a warming climate. This Web site contains a University of Alberta press release detailing this first-ever demonstration of genetic adaptation to global warming. With implications that extend far beyond the immediate research concerns of geneticists and environmental scientists, Boutin's work as presented in this Web site should be interesting to wide audience.

Dey, Phoebe.

2003-01-01

246

Research on the key technology and application of the packet transmission network  

NASA Astrophysics Data System (ADS)

In proportion to the rapid development of telecommunication service, Telecom Operators already have made a strategic transition from "Network, Communication Operators" into "integrated information service provider" to provide customer with varied information service, such as the BT "21st century plan", "Next" plan proposed by France Telecom, FNE and BMS plan by Australia Telstra, RANE Programs by NTT. Domestic Carries also made strategic transition plans. And the priority of network transition is to find the way to build a unified and integrated network supporting carrier-grade Ethernet service also compatible with the conventional network service. The division of the service results in the Packet transmission, namely packet technology, makes Packet-based Transmission Network keeping the virtues of transmission network. The virtues are good scalability, varied operation and maintenance, high-speed protection switching, connection-oriented feature, and building up connection with NMS. At the same time, it adds some characteristics to adapt the statistical multiplexing in the packet service, for instance: connection-oriented label switching, QoS mechanism, dynamic and flexible control plane. The Packet Transmission Network (PTN) can be divided into four layers: packet transmission channel layer (PTC), packet transmission path layer (PTP), and optional packet transmission section Layer (PTS) and physical layer. The key technologies of PTN are as follows: the connection-oriented based label transmission and the statistical multiplexing on packet switching. The use of layer and sub-domain is to provide good scalability. Supporting for fault detection and performance testing and other Operation, Management and Maintenance (OAM) function, linear protection switching, ring protection, dynamics survival technology of pre-placed re-route, QoS, circuit emulation for TDM service, ATM based on PWE3 technique, and MAC layer or physical layer based packet clock synchronization. The application PTN could be convergence of packet service in MAN, such ads DSLAM backhauling, wireless Backhauling and so on. PTN can also take replace the core router in the core network to carry out the high efficient transmission of packet service.

Yun, Xiang; Wang, Zhong

2009-08-01

247

Key factors influencing enterprise to improve it application level: Stage difference research — An empirical research on 165 enterprises through field study  

Microsoft Academic Search

Though there were a large number of researches on critical success factors of enterprise information technology (IT) applications, but lack of researches on the difference during the different stages of IT assimilation. Because of this, this article discusses the influence difference of five managerial key factors inside organization to the enterprises IT application level during the stages of adoption and

Xiao Jing-hua; Xie Kang; Wan Xiao-wei

2010-01-01

248

Research on the caretaking of children of incarcerated parents: Findings and their service delivery implications  

Microsoft Academic Search

This paper reviews research findings on caretaking-related problems associated with the absence of parents from the home following incarceration. It focuses on the impact of incarceration on the welfare and adjustment of urban African American children and on the assumption of caretaking responsibilities by other caretakers, principally maternal grandmothers. Noting the complex situational difficulties involved and the potential burdens associated

Thomas E. Hanlon; Steven B. Carswell; Marc Rose

2007-01-01

249

Undersea researchers find little oil spill damage so far By KRISTA KLAUS | News Channel 8  

E-print Network

Undersea researchers find little oil spill damage so far By KRISTA KLAUS | News Channel 8 Published of the Gulf of Mexico in the wake of BP's massive Deepwater Horizon oil spill made a brief stopover today life before and after the largest oil spill in the history of the Gulf of Mexico. #12;"This

Belogay, Eugene A.

250

The method is the messageExplaining inconsistent findings in gender and news production research  

Microsoft Academic Search

Whether, and how, gender affects the news product is one of the most challenging areas in the field of gender and the media. This article analyzes the impact of specific research methodologies on findings regarding gender news influence - based on survey questionnaires and in-depth interviews of female and male editors working in Israeli public radio, as well as on

Aliza Lavie; Sam Lehman-Wilzig

2005-01-01

251

A framework for analyzing the ethics of disclosing genetic research findings.  

PubMed

Whether researchers have an obligation to disclose secondary genetic research findings, and, if so, in what circumstances, remains a matter of heated debate. This paper suggests that much of this confusion is definitional or conceptual in nature. That is, there is significant variability in the way that threshold terms and concepts such as "incidental," "analytic validity," "clinical validity," "clinical relevance," "clinical utility," "clinical significance," and "actionability," are used in the literature, which is impeding efforts to clarify the scope of an obligation to return findings. This paper analyzes the definitional muddle underlying the debate about returning genetic research findings, first, to explain the range of definitions being used in this debate. We go on to propose that, underlying all the seeming confusion and disagreement, three central and widely agreed upon concepts are at work in this debate - validity, value, and volition. Refocusing attention on these core concepts, and their appropriate conceptualizations, can produce a more productive debate regarding the return of genetic research findings. PMID:25040383

Eckstein, Lisa; Garrett, Jeremy R; Berkman, Benjamin E

2014-01-01

252

Human Microbiome Project Researchers Find Vast Individual Differences in Our Bacteria  

E-print Network

female), collecting tissues from 15 body sites in men and 18 body sites in women (including three vaginal population differences both between areas in each body and between similar areas in different bodies. EachHuman Microbiome Project Researchers Find Vast Individual Differences in Our Bacteria When

Howitt, Ivan

253

Edinburgh Research Explorer Epidemiological and postmortem findings in 262 red squirrels  

E-print Network

Edinburgh Research Explorer Epidemiological and postmortem findings in 262 red squirrels (Sciurus squirrels (Sciurus vulgaris) in Scotland, 2005 to 2009' Veterinary Record, vol 167, no. 8, pp. 297-302., 10 on 262 red squirrels (Sciurus vulgaris) found dead or moribund in Scotland between September 2005

Swain, Peter

254

Kimmel Cancer Center researchers find biomarker links clinical outcome with new model of lethal tumor metabolism  

Cancer.gov

Researchers at the Kimmel Cancer Center at Jefferson have demonstrated for the first time that the metabolic biomarker MCT4 directly links clinical outcomes with a new model of tumor metabolism that has patients “feeding” their cancer cells. Their findings were published online March 15 in Cell Cycle.

255

Research report Stress eating and health. Findings from MIDUS, a national study  

E-print Network

Research report Stress eating and health. Findings from MIDUS, a national study of US adults q Vera 2013 Keywords: Stress eating Diabetes Obesity National study a b s t r a c t The epidemic of obesity balance by describing pathways to energy imbalance. Studies on triggers of eating behaviors document

Wisconsin at Madison, University of

256

Finding links to cancer Masonic Cancer Center researchers work to identify carcinogens  

E-print Network

Finding links to cancer Masonic Cancer Center researchers work to identify carcinogens in the world around us--as well as ways to avoid them When scientists talk about "environmental" causes of cancer are linked to as many as two out of every three cancers diagnosed. DeAnn Lazovich, Ph.D., M.P.H., is one

Minnesota, University of

257

Researchers Find Abnormal Cells in the Blood Years before Leukemia is Diagnosed  

Cancer.gov

Researchers have shown that abnormal white blood cells can be present in patients' blood more than six years prior to the diagnosis of a chronic form of lymphocytic leukemia. This finding may lead to a better understanding of the cellular changes that characterize the earliest stages of the disease and how it progresses.

258

Indiana U researchers find that blood test could help to diagnose pancreatic cancer  

Cancer.gov

Indiana U researchers find that a blood test could help to diagnose pancreatic cancer. The disease is difficult to diagnose in early stages because the pancreas is hidden behind other organs such as the stomach, small intestine, liver, gallbladder, spleen and bile ducts.

259

Public Understanding of Cognitive Neuroscience Research Findings: Trying to Peer beyond Enchanted Glass  

ERIC Educational Resources Information Center

This article considers the appeal of cognitive neuroscience research to the general public within the context of the deep puzzles involved in using our minds to understand how our minds work. It offers a few promising examples of findings that illuminate the ways of the mind and reveal these workings to be counter-intuitive with our subjective…

Grotzer, Tina A.

2011-01-01

260

Key Challenges for Tertiary Education Policy and Research--An Australian Perspective  

ERIC Educational Resources Information Center

Australia has had a mixed history in the way in which policy research has related to higher education policy. Recognising a history of policy-related research and to some extent research-informed policy-making, Australia has followed the trend of other New Public Management-driven systems of de-emphasising policy-oriented independent research. In…

Goedegebuure, Leo; Schoen, Marian

2014-01-01

261

The NASA research and technology program on space power: A key element of the Space Exploration Initiative  

NASA Technical Reports Server (NTRS)

In July 1989, President Bush announced his space exploration initiative of going back to the Moon to stay and then going to Mars. Building upon its ongoing research and technology base, NASA has established an exploration technology program to develop the technologies needed for piloted missions to the Moon and Mars. A key element for the flights and for the planned bases is power. The NASA research and technology program on space power encompasses power sources, energy storage, and power management.

Bennett, Gary L.; Brandhorst, Henry W., Jr.; Atkins, Kenneth L.

1991-01-01

262

Unternehmen und Social Media wie passt das zusammen? Dr. Alexander Stocker, Key Researcher, DIGITAL Institut fr Informations und  

E-print Network

Unternehmen und Social Media ­ wie passt das zusammen? Dr. Alexander Stocker, Key Researcher;Unternehmen und Soziale Medien­ wie passt das zusammen? Social Media bezeichnet die Transformation der Nutzer von Konsumenten zu Produzenten von Inhalten. Der Einsatz von Social Media im Kontext von

Hammerton, James

263

Global Energy Technology Strategy: Addressing Climate Change Phase 2 Findings from an international Public-Private Sponsored Research Program  

SciTech Connect

This book examines the role of global energy technology in addressing climate change. The book considers the nature of the climate change challenge and the role of energy in the issue. It goes on to consider the implications for the evolution of the global energy system and the potential value of technology availability, development and deployment. Six technology systems are identified for special consideration: CO2 capture and storage, Biotechnology, Hydrogen systems, Nuclear energy, Wind and solar energy, and End-use energy technologies. In addition, consideration is given to the role of non-CO2 gases in climate change as well as the potential of technology development and deployment to reduce non-CO2 emissions. Present trends in energy R&D are examined and potentially fruitful avenues for research. The book concludes with a set of key findings.

Edmonds, James A.; Wise, Marshall A.; Dooley, James J.; Kim, Son H.; Smith, Steven J.; Runci, Paul J.; Clarke, Leon E.; Malone, Elizabeth L.; Stokes, Gerald M.

2007-05-01

264

Increased Attention to Human Sexuality Can Improve HIV–AIDS Prevention Efforts:: Key Research Issues and Directions  

Microsoft Academic Search

Curtailing the human immunodeficiency virus (HIV) epidemic requires the development of effective strategies for helping people reduce high-risk sexual behavior patterns. Because the objective of HIV prevention involves changing how people behave sexually, research findings in human sexuality are extremely pertinent to efforts to promote AIDS risk reduction. Unfortunately, most public health HIV prevention programs rarely reflect findings of human

Jeffrey A. Kelly; Seth C. Kalichman

1995-01-01

265

Key Technology Research on the Flexible Welding Line for Multi-model Automobile  

Microsoft Academic Search

The paper shows that establishing the flexible multi- model welding line (FMWL) is necessary, which is the key technology for the flexible production. In this paper, some measures for implementing the flexible welding line for multi- model automobile were proposed from several aspects, such as process planning, switching mechanism, the robot interactive simulation, and automatic integrated control. And the modular

Xianghong Yang

2011-01-01

266

Research on incentive mechanism of key technical staff in electric power enterprise  

Microsoft Academic Search

Motivation is an important function in the human re- source management. Motivation is the key of human resource management, so we must pay attention to the needs of employees, offer and develop all kinds of motivation resource in order to achieve good results. Electric power enterprise also needs effec- tive motivation management. But now, there are some problems in it.

Liyan Du

2011-01-01

267

Research on Application of Key Infrastructure Algorithm about Smart IC Card System  

Microsoft Academic Search

A new method of optimized path planning about smart card based on Dijkstra algorithm is proposed in this paper, for the path planning problem of China road charges. The IC Card Key Infrastructure and CRC check code technology of city uni-card system are combined in the algorithm, and the division with the shortest path using the minimum rate of fees

Xie JianHua; Zhong JianPeng

2009-01-01

268

Key Elements and challenges of USEPA?s developing ecological services research program  

EPA Science Inventory

Over the past year, EPA?s Office of Research and Development (ORD) has redirected research within the Ecological Services Research Program (ESRP) to focus on ecosystem services and their associated benefits to human well-being. By 2009, all of EPA/ORD?s Ecological Services Resear...

269

Identification and Characterization of Key Human Performance Issues and Research in the Next Generation Air Transportation System (NextGen)  

NASA Technical Reports Server (NTRS)

This report identifies key human-performance-related issues associated with Next Generation Air Transportation System (NextGen) research in the NASA NextGen-Airspace Project. Four Research Focus Areas (RFAs) in the NextGen-Airspace Project - namely Separation Assurance (SA), Airspace Super Density Operations (ASDO), Traffic Flow Management (TFM), and Dynamic Airspace Configuration (DAC) - were examined closely. In the course of the research, it was determined that the identified human performance issues needed to be analyzed in the context of NextGen operations rather than through basic human factors research. The main gaps in human factors research in NextGen were found in the need for accurate identification of key human-systems related issues within the context of specific NextGen concepts and better design of the operational requirements for those concepts. By focusing on human-system related issues for individual concepts, key human performance issues for the four RFAs were identified and described in this report. In addition, mixed equipage airspace with components of two RFAs were characterized to illustrate potential human performance issues that arise from the integration of multiple concepts.

Lee, Paul U.; Sheridan, Tom; Poage, james L.; Martin, Lynne Hazel; Jobe, Kimberly K.

2010-01-01

270

Repackaging Prostate Cancer Support Group Research Findings: An e-KT Case Study.  

PubMed

In the context of psychosocial oncology research, disseminating study findings to a range of knowledge "end-users" can advance the well-being of diverse patient subgroups and their families. This article details how findings drawn from a study of prostate cancer support groups were repackaged in a knowledge translation website-www.prostatecancerhelpyourself.ubc.ca-using Web 2.0 features. Detailed are five lessons learned from developing the website: the importance of pitching a winning but feasible idea, keeping a focus on interactivity and minimizing text, negotiating with the supplier, building in formal pretests or a pilot test with end-users, and completing formative evaluations based on data collected through Google™ and YouTube™ Analytics. The details are shared to guide the e-knowledge translation efforts of other psychosocial oncology researchers and clinicians. PMID:24713522

Oliffe, John L; Han, Christina S; Lohan, Maria; Bottorff, Joan L

2015-01-01

271

UNC researchers find new genetic target for a different kind of cancer drug  

Cancer.gov

Researchers from the UNC School of Medicine have discovered that the protein RBM4, a molecule crucial to the process of gene splicing, is drastically decreased in multiple forms of human cancer, including lung and breast cancers. The finding, published in the journal Cancer Cell, offers a new route toward therapies that can thwart the altered genetic pathways that allow cancer cells to proliferate and spread.

272

Research on the key techniques of fiber optic gyroscopes in space applications  

NASA Astrophysics Data System (ADS)

The advantages and the characteristics of the fiber optic gyroscopes (FOGs) for the space application, compared with the traditional mechanical gyroscope and the laser gyroscope, have been mentioned. There are differences of the FOG designing between application in space and other conditions especially the radiation-resistant, low power cost and less weight of the FOG. The key techniques of the fiber optic gyros technology have been proposed and some test results have been discussed.

Xiao, Wen; Liu, Dewen; Zhang, Yuyan

2005-11-01

273

Key Stakeholders' Perceptions of Effective School Leadership  

Microsoft Academic Search

There has been limited research on how teachers, parents and students perceive effective school leadership in practice. The purpose of this article is to present some of the findings derived from a study of key stakeholders’ perceptions of effective school leadership. Key stakeholders were identified as teachers, students and parents. Data were gathered through semi-structured interviews with key stakeholders from

George Odhiambo; Amy Hii

2012-01-01

274

Language of instruction in Tanzania: Why are research findings not heeded?  

NASA Astrophysics Data System (ADS)

The issue of language of instruction (LOI) and its effects on education in Tanzanian secondary education has been widely researched since the early 1980s. In 2009, the Ministry of Education and Vocational Training proposed a new education and training policy that allows English to be used as LOI from nursery school to tertiary education. The proposed policy goes against what researchers in this area have recommended over the years. In the light of the proposed policy, the author of this article felt the need to review studies done on LOI in Tanzania from 1974 to date, aiming to eliminate or greatly reduce the negative effects of the policy on education in Tanzania. Quoting examples, the paper demonstrates students' levels of proficiency in English; suggests reasons why governmental policy has over time ignored research findings; and recommends as well as proposes the way forward.

Qorro, Martha A. S.

2013-06-01

275

Research on key techniques of nanometer scale macro-micro dual-drive precision positioning  

NASA Astrophysics Data System (ADS)

With the development of science and technology, high precision of positioning platform is needed in many areas, for example, cell fusing in biology and precision surgery in medical area. In such areas, both high efficiency and high precision are needed in some cases, for example, semiconductor processing equipment, super precision lathe etc. In a word, precision positioning platform becomes an important tool in exploring microscope world. Precision positioning platform is a key element in microscope operation. Macro/micro dual-drive precision positioning is a key technique in high-efficiency high-precision area. By such techniques, large distance and high precision can get. In order to realize nanometer scale macro/micro dual-drive precision positioning there are some key problems. First, system structure of macro/micro combination precision positioning platform is worthy to work on. Another key work is realization method of micrometer scale macroscope motion and nanometer scale microscope motion. The third is mechanics, drive, detection and control techniques in nanometer scale positioning of piezoelectric ceramics drive, in which realization of nanometer scale microscope positioning and micro drive is important by solving hysteresis, creep deformation and non-linearity in piezoelectric ceramics driving. To solve hysteresis problem, instead of traditional Preisach algorithm, a new type hysteresis model with simple computation and identification is needed. The inverse model is also easily to get. So we can present new control method to solve hysteresis and creep deformation problem based on this inverse model. Another way, hysteresis and creep deformation problem exist in traditional voltage-feedback power source for piezoelectric ceramics. To solve this problem, a new type current feedback power source for piezoelectric ceramics is presented. In the end, a macro-micro dual-drive super precision positioning mechanism is presented. Combining macro with micro actuator, a system with large workspace and high resolution of motion is presented. The linear direct-drive motor is used in the macroscope motion and high frequency PZT-driven microscope stage is embedded in the motor and compensates the position error. A high-resolution linear encoder is integrated into the closed-loop feedback, which is used to measure the position of the end-effect in microscope scale.

Xie, Xiaohui; Du, Ruxu

2007-12-01

276

Subsonic Transonic Applied Refinements By Using Key Strategies - STARBUKS In the NASA Langley Research Center National Transonic Facility  

NASA Technical Reports Server (NTRS)

Several upgrade projects have been completed at the NASA Langley Research Center National Transonic Facility over the last 1.5 years in an effort defined as STARBUKS - Subsonic Transonic Applied Refinements By Using Key Strategies. This multi-year effort was undertaken to improve NTF's overall capabilities by addressing Accuracy and Validation, Productivity, and Reliability areas at the NTF. This presentation will give a brief synopsis of each of these efforts.

Paryz, Roman W.

2014-01-01

277

Findings of the US research needs workshop on the topic of fusion power  

SciTech Connect

The US Department of Energy, Of?ce of Fusion Energy Sciences (OFES) conducted a Research Needs Workshop, referred to as ReNeW, in June 2009. The information developed at this workshop will help OFES develop a plan for US fusion research during the ITER era, roughly the next two decades. The workshop was organized in ?ve Themes, one of which was Harnessing Fusion Power (or Fusion Power for short). The top level goal of the Fusion Power Theme was to identify the research needed to develop the knowledge to design and build, with high con?dence, robust and reliable systems that can convert fusion products to useful forms of energy in a reactor environment, including a self-suf?cient supply of tritium fuel. Each Theme was subsequently subdivided into Panels to address speci?c topics. The Fusion Power Panel topics were: Fusion Fuel Cycle; Power Extraction; Materials Science; Safety and Environment; and Reliability, Availability, Maintainability and Inspectability (RAMI). Here we present the key ?ndings of the Fusion Power Theme.

Meier, Wayne R.; Raffray, R.; Kurtz, Richard J.; Morley, Neil B.; Reiersen, Wayne T.; Sharpe, Phil; Willms, Scott

2010-12-01

278

On norms and bodies: findings from field research on cosmetic surgery in Rio de Janeiro, Brazil.  

PubMed

Brazil has the second highest rate of cosmetic surgery worldwide, provided in a large number of public and private clinics and hospitals, especially in the southeast. This qualitative field research in Rio de Janeiro included participant observation and in-depth interviews with 18 women cosmetic surgery patients, 10 key informants (e.g. psychologists and sociologists) and 12 plastic surgeons. Fifteen of the women were either pre- or post-operative; three had not decided whether to have surgery. When asked about their motivations and expectations of the surgery, the majority of the women said they wanted to be "normal". Most of the surgeons said they acted as empathic companions from decision-making through surgery and beyond. Many of the key informants were critical of what was happening to medical ethics in relation to cosmetic surgery. With the growth in a consumer culture, they saw ethics in medicine becoming more bendable and subject to the "law" of the market. The cult of the body has become a mass phenomenon and taken on an important social dimension in a society where norms and images are broadcast widely by the media. The trend towards body-modification by cosmetic surgery at an early age is increasing dramatically. What demands critical thinking and further investigation are the consequences of cosmetic surgery for physical and mental health. PMID:20541086

Dorneles de Andrade, Daniela

2010-05-01

279

For Immediate Release --Monday, December 2, 2013 University of Lethbridge researcher plays key role in  

E-print Network

, the United States and South Korea is driven by global and regional income Social Sciences and Humanities Research Council (SSHRC) Partnership Grant on Gender, Migration and the Work of Care, centered at the University of Toronto, is leading

Seldin, Jonathan P.

280

University of Pittsburgh Cancer Institute researchers identify key oncoprotein found in Merkel Cell Carcinoma:  

Cancer.gov

Researchers at the University of Pittsburgh Cancer Institute (UPCI) have identified the oncoprotein that allows a common and usually harmless virus to transform healthy cells into a rare but deadly skin cancer called Merkel Cell Carcinoma (MCC).

281

Conducting and Evaluating Critical Interpretive Research: Examining Criteria as a Key Component in Building a Research Tradition  

Microsoft Academic Search

The collection, analysis, and interpretation of empirical materials are always conducted within some broader understanding\\u000a of what constitutes legitimate inquiry and valid knowledge. In the Information Systems field, there are wellknown and widely\\u000a accepted methodological principles consistent with the conventions of positivism. However, the same is not yet true of interpretive\\u000a research. The emergence of interpretivism in IS research was

Marlei Pozzebon

282

The role of cellular senescence during vascular calcification: a key paradigm in aging research.  

PubMed

Vascular calcification has severe clinical consequences and is considered an accurate predictor of future adverse cardiovascular events. Vascular calcification refers to the deposition of calcium phosphate mineral, most often hydroxyapatite, in arteries. Extensive calcification of the vascular system is a key characteristic of aging. In this article, we outline the mechanisms governing vascular calcification and highlight its association with cellular senescence. This review discusses the molecular mechanisms of cellular senescence and its affect on calcification of vascular cells, the relevance of phosphate regulation and the function of FGF23 and Klotho proteins. The association of vascular calcification and cellular senescence with the rare human aging disorder Hutchison-Gilford Progeria Syndrome (HGPS) is highlighted and the mouse models used to try to determine the underlying pathways are discussed. By understanding the pathways involved in these processes novel drug targets may be elucidated in an effort to reduce the effects of cellular aging as a risk factor in cardiovascular disease. PMID:21235497

Mackenzie, N C W; MacRae, V E

2011-07-01

283

Dana-Farber researchers find new culprit in castration-resistant prostate cancer  

Cancer.gov

Scientists at Dana-Farber Cancer Institute have discovered a molecular switch that enables advanced prostate cancers to spread without stimulation by male hormones, which normally are needed to spur the cancer's growth. They say the finding could lead to a new treatment for prostate cancers that are no longer controlled by hormone-blocking drugs. The researchers report in the Dec. 14 issue of Science that the molecular switch occurs in a protein, EZH2, which is increased in these tumors, termed castration-resistant prostate cancers (CRPC).

284

Stanford researchers find antibody hinders growth of Gleevec-resistant gastrointestinal tumors in lab tests  

Cancer.gov

An antibody that binds to a molecule on the surface of a rare but deadly tumor of the gastrointestinal tract inhibits the growth of the cancer cells in mice, according to researchers at the Stanford University School of Medicine (home of the Stanford Cancer Institute). The effect remains even when the cancer cells have become resistant to other treatments, and the findings may one day provide a glimmer of hope for people with the cancer, known as gastrointestinal stromal tumor, or GIST. The scientists hope to move into human clinical trials of the antibody within two years.

285

Identifying tier one key suppliers.  

PubMed

In today's global marketplace, businesses are becoming increasingly reliant on suppliers for the provision of key processes, activities, products and services in support of their strategic business goals. The result is that now, more than ever, the failure of a key supplier has potential to damage reputation, productivity, compliance and financial performance seriously. Yet despite this, there is no recognised standard or guidance for identifying a tier one key supplier base and, up to now, there has been little or no research on how to do so effectively. This paper outlines the key findings of a BCI-sponsored research project to investigate good practice in identifying tier one key suppliers, and suggests a scalable framework process model and risk matrix tool to help businesses effectively identify their tier one key supplier base. PMID:23615061

Wicks, Steve

2013-01-01

286

Signature Concepts of Key Researchers in Higher Education Teaching and Learning  

ERIC Educational Resources Information Center

Early career university teachers often have limited experience of the higher education literature making it difficult for them to identify what ideas have become central to justifying what university teachers ought to be doing in higher education teaching and learning. A review of the research literature in journals focused on teaching and…

Kandlbinder, Peter

2013-01-01

287

Key Implementation Considerations for Executing Evidence-Based Programs: Project Overview. ASPE Research Brief  

ERIC Educational Resources Information Center

In April 2011, the U.S. Department of Health and Human Services (HHS) Office of the Assistant Secretary for Planning and Evaluation (ASPE) hosted a Forum, Emphasizing Evidence-Based Programs for Children and Youth, to convene the nation's leading practitioners and researchers with experience using and evaluating an array of evidence-based…

US Department of Health and Human Services, 2013

2013-01-01

288

Research Implications for Science and Mathematics Teachers. Volume 1. Key Centre Monograph Number 5.  

ERIC Educational Resources Information Center

This document was compiled to help keep science and mathematics teachers in Australia abreast of the results of important research endeavors in education. The monograph is divided into 12 chapters. Chapter one, "Exemplary Science and Mathematics Teachers," (Barry Fraser and Kenneth Tobin) describes a study focusing on examples of outstanding…

Fraser, Barry J., Ed.

289

Supporting international students in UK Higher Education: key issues, and recommendations for further research  

Microsoft Academic Search

Because one of the criticisms of existing research is that it lacks insight into the political, economic and organisational context (Pelletier 2003), this review begins with an overview of UK HE policies over the past 3 decades which have impacted on the way institutions perceive and deal with international students. The second section outlines non-academic issues which may affect international

Carol Bailey

290

Online Community and Professional Learning in Education: Research-Based Keys to Sustainability  

ERIC Educational Resources Information Center

Though the concept of online community has been heralded as a promising tool to support teacher professional development, a robust and meaningful definition remains elusive. This review draws together research on community, teaching, and learning in traditional and online settings. Examples of current efforts in the field of online learning…

Havelock, Bruce

2004-01-01

291

Finding a voice: participatory research with street-involved youth in the youth injection prevention project.  

PubMed

This article uses a Positive Youth Development framework to explore the experiences of six experiential youth coresearchers (YCs) in the Youth Injection Prevention (YIP) participatory research project, and the parallel track process of empowerment and capacity building that developed. The YIP project was conducted in Metro Vancouver at the BC Centre for Disease Control and community organizations serving street-involved youth. A process evaluation was conducted to explore themes in the YCs experience in the project, as well as process strengths and challenges. Semistructured interviews with the YCs, researcher field notes, and team meeting and debrief session minutes were analyzed. The YIP project appears to have exerted a positive influence on the YCs. Positive self-identities, sense of purpose, reconceptualization of intellectual ability, new knowledge and skills, supportive relationships, finding a voice, and social and self-awareness were among the positive impacts. Process strengths included team-building activities, team check-in and checkout sessions, and professional networking opportunities. Process challenges included the time required to help YCs overcome personal barriers to participation. The YIP project demonstrates that participatory research with street-involved youth is a viable research option that contributes to positive youth development and empowerment. PMID:24668583

Coser, Larissa Rodrigues; Tozer, Kira; Van Borek, Natasha; Tzemis, Despina; Taylor, Darlene; Saewyc, Elizabeth; Buxton, Jane A

2014-09-01

292

Science in the Eyes of Preschool Children: Findings from an Innovative Research Tool  

NASA Astrophysics Data System (ADS)

How do young children view science? Do these views reflect cultural stereotypes? When do these views develop? These fundamental questions in the field of science education have rarely been studied with the population of preschool children. One main reason is the lack of an appropriate research instrument that addresses preschool children's developmental competencies. Extensive body of research has pointed at the significance of early childhood experiences in developing positive attitudes and interests toward learning in general and the learning of science in particular. Theoretical and empirical research suggests that stereotypical views of science may be replaced by authentic views following inquiry science experience. However, no preschool science intervention program could be designed without a reliable instrument that provides baseline information about preschool children's current views of science. The current study presents preschool children's views of science as gathered from a pioneering research tool. This tool, in the form of a computer "game," does not require reading, writing, or expressive language skills and is operated by the children. The program engages children in several simple tasks involving picture recognition and yes/no answers in order to reveal their views about science. The study was conducted with 120 preschool children in two phases and found that by the age of 4 years, participants possess an emergent concept of science. Gender and school differences were detected. Findings from this interdisciplinary study will contribute to the fields of early childhood, science education, learning technologies, program evaluation, and early childhood curriculum development.

Dubosarsky, Mia D.

293

Low-Temperature Biodiesel Research Reveals Potential Key to Successful Blend Performance (Fact Sheet)  

SciTech Connect

Relatively low-cost solutions could improve reliability while making biodiesel blends an affordable option. While biodiesel has very low production costs and the potential to displace up to 10% of petroleum diesel, until now, issues with cold weather performance have prevented biodiesel blends from being widely adopted. Some biodiesel blends have exhibited unexplained low-temperature performance problems even at blend levels as low as 2% by volume. The most common low-temperature performance issue is vehicle stalling caused by fuel filter clogging, which prevents fuel from reaching the engine. Research at the National Renewable Energy Laboratory (NREL) reveals the properties responsible for these problems, clearing a path for the development of solutions and expanded use of energy-conserving and low-emissions alternative fuel. NREL researchers set out to study the unpredictable nature of biodiesel crystallization, the condition that impedes the flow of fuel in cold weather. Their research revealed for the first time that saturated monoglyceride impurities common to the biodiesel manufacturing process create crystals that can cause fuel filter clogging and other problems when cooling at slow rates. Biodiesel low-temperature operational problems are commonly referred to as 'precipitates above the cloud point (CP).' NREL's Advanced Biofuels team spiked distilled soy and animal fat-derived B100, as well as B20, B10, and B5 biodiesel blends with three saturated monoglycerides (SMGs) at concentration levels comparable to those of real-world fuels. Above a threshold or eutectic concentration, the SMGs (monomyristin, monopalmitin, and monostearin) were shown to significantly raise the biodiesel CP, and had an even greater impact on the final melting temperature. Researchers discovered that upon cooling, monoglyceride initially precipitates as a metastable crystal, but it transforms over time or upon slight heating into a more stable crystal with a much lower solubility and higher melting temperature - and with increased potential to cause vehicle performance issues. This explains why fuel-filter clogging typically occurs over the course of long, repeated diurnal cooling cycles. The elevated final melting points mean that restarting vehicles with clogged filters can be difficult even after ambient temperatures have warmed to well above CP. By examining how biodiesel impurities affect filtration and crystallization during warming and cooling cycles, NREL researchers uncovered an explanation for poor biodiesel performance at low temperatures. The observation of a eutectic point, or a concentration below which SMGs have no effect, indicates that SMGs do not have to be completely removed from biodiesel to solve low-temperature performance problems.

Not Available

2012-02-01

294

Summary of Key Research Findings Leading up to MOR2 Project Ecological Findings from 1994-1995 Fieldwork in Bayankhongor Aimag  

E-print Network

in species composition. Soil texture was also important in the desert-steppe. · In the mountain/forest steppe-annual variation in precipitation explains more of the variation in vegetation cover, species composition intensity significantly influences plant cover, biomass and species composition. · Steppe systems have

295

New research models and novel signal analysis in studies on preterm labor: a key to progress?  

PubMed Central

Preterm labor affects up to 20% of pregnancies, is considered a main cause of associated neonatal morbidity and mortality and is responsible for neonatal care costs of multimillion euros. In spite of that, the commercial market for this clinical indication is rather limited, which may be also related to high liability. Consequently, with only a few exceptions, preterm labor is not in the orbit of great interest of the pharmaceutical industry. Coordinated effort of research community may bring the change and help required to reduce the influence of this multifactorial syndrome on society. Between the novel techniques that are being explored in a SAFE (The Special Non-Invasive Advances in Fetal and Neonatal Evaluation Network) group, there are new research models of preterm labor as well as novel methodology of analysis of biological signals. In this article, we briefly describe new clinical and nonclinical human models of preterm labor as well as summarize some novel methods of data processing and analysis that may be used in the context of preterm labor. PMID:17570166

Pierzynski, Piotr; Oczeretko, Edward; Laudanski, Piotr; Laudanski, Tadeusz

2007-01-01

296

Sexual Abuse and Exploitation of Boys in South Asia. A review of research findings, legislation, policy and programme responses  

Microsoft Academic Search

This paper provides an overview of research findings, legislation, policy and programme responses to prevent and respond to the sexual abuse and exploitation of boys in South Asia. The background to the paper is based on the findings from previous UNICEF IRC research on child trafficking in the region, which indicated that boys enjoy less legal protection than girls from

John Frederick

2010-01-01

297

Exome Sequencing and Unrelated Findings in the Context of Complex Disease Research: Ethical and Clinical Implications  

PubMed Central

Exome sequencing has identified the causes of several Mendelian diseases, although it has rarely been used in a clinical setting to diagnose the genetic cause of an idiopathic disorder in a single patient. We performed exome sequencing on a pedigree with several members affected with attention deficit/hyperactivity disorder (ADHD), in an effort to identify candidate variants predisposing to this complex disease. While we did identify some rare variants that might predispose to ADHD, we have not yet proven the causality for any of them. However, over the course of the study, one subject was discovered to have idiopathic hemolytic anemia (IHA), which was suspected to be genetic in origin. Analysis of this subject’s exome readily identified two rare non-synonymous mutations in PKLR gene as the most likely cause of the IHA, although these two mutations had not been documented before in a single individual. We further confirmed the deficiency by functional biochemical testing, consistent with a diagnosis of red blood cell pyruvate kinase deficiency. Our study implies that exome and genome sequencing will certainly reveal additional rare variation causative for even well-studied classical Mendelian diseases, while also revealing variants that might play a role in complex diseases. Furthermore, our study has clinical and ethical implications for exome and genome sequencing in a research setting; how to handle unrelated findings of clinical significance, in the context of originally planned complex disease research, remains a largely uncharted area for clinicians and researchers. PMID:21794208

Lyon, Gholson J.; Jiang, Tao; Van Wijk, Richard; Wang, Wei; Bodily, Paul Mark; Xing, Jinchuan; Tian, Lifeng; Robison, Reid J.; Clement, Mark; Lin, Yang; Zhang, Peng; Liu, Ying; Moore, Barry; Glessner, Joseph T.; Elia, Josephine; Reimherr, Fred; van Solinge, Wouter W.; Yandell, Mark; Hakonarson, Hakon; Wang, Jun; Johnson, William Evan; Wei, Zhi; Wang, Kai

2012-01-01

298

UKERC ENERGY RESEARCH ATLAS: CARBON CAPTURE AND STORAGE (version 10 February 2008) Section 1: An overview which includes a broad characterisation of research activity in the sector and the key research challenges  

E-print Network

UKERC ENERGY RESEARCH ATLAS: CARBON CAPTURE AND STORAGE (version 10 February 2008) Section 1: An overview which includes a broad characterisation of research activity in the sector and the key research challenges Section 2: An assessment of UK capabilities in relation to wider international activities

Haszeldine, Stuart

299

Regenerating the academic workforce: the careers, intentions and motivations of higher degree research students in Australia: findings of the National Research Student Survey (NRSS)  

Microsoft Academic Search

The main findings of this report are based on the outcomes from the National Research Student Survey (NRSS) conducted in June 2010 across 38 of the 39 universities in Australia. In total 11,710 Higher Degree by Research students (those enrolled in PhD and masters by research degrees, also referred to simply as ‘research students’ in this report) responded to the

Daniel Edwards; Emmaline Bexley; Sarah Richardson

2011-01-01

300

Network structure and the role of key players in a translational cancer research network: a study protocol  

PubMed Central

Introduction Translational research networks are a deliberate strategy to bridge the gulf between biomedical research and clinical practice through interdisciplinary collaboration, supportive funding and infrastructure. The social network approach examines how the structure of the network and players who hold important positions within it constrain or enable function. This information can be used to guide network management and optimise its operations. The aim of this study was to describe the structure of a translational cancer research network (TCRN) in Australia over its first year, identify the key players within the network and explore these players' opportunities and constraints in maximising important network collaborations. Methods and analysis This study deploys a mixed-method longitudinal design using social network analysis augmented by interviews and review of TCRN documents. The study will use network documents and interviews with governing body members to explore the broader context into which the network is embedded as well as the perceptions and expectations of members. Of particular interest are the attitudes and perceptions of clinicians compared with those of researchers. A co-authorship network will be constructed of TCRN members using journal and citation databases to assess the success of past pre-network collaborations. Two whole network social network surveys will be administered 12?months apart and parameters such as density, clustering, centrality and betweenness centrality computed and compared using UCINET and Netdraw. Key players will be identified and interviewed to understand the specific activities, barriers and enablers they face in that role. Ethics and dissemination Ethics approvals were obtained from the University of New South Wales, South Eastern Sydney Northern Sector Local Health Network and Calvary Health Care Sydney. Results will be discussed with members of the TCRN, submitted to relevant journals and presented as oral presentations to clinicians, researchers and policymakers. PMID:22734122

Cunningham, Frances C; Braithwaite, Jeffrey

2012-01-01

301

Hypnotic approaches for chronic pain management: clinical implications of recent research findings.  

PubMed

The empirical support for hypnosis for chronic pain management has flourished over the past two decades. Clinical trials show that hypnosis is effective for reducing chronic pain, although outcomes vary between individuals. The findings from these clinical trials also show that hypnotic treatments have a number of positive effects beyond pain control. Neurophysiological studies reveal that hypnotic analgesia has clear effects on brain and spinal-cord functioning that differ as a function of the specific hypnotic suggestions made, providing further evidence for the specific effects of hypnosis. The research results have important implications for how clinicians can help their clients experience maximum benefits from hypnosis and treatments that include hypnotic components. PMID:24547802

Jensen, Mark P; Patterson, David R

2014-01-01

302

Assessing the acceptability of NORPLANT implants in four countries: findings from focus group research.  

PubMed

In 1986-87, a qualitative research project was conducted in the Dominican Republic, Egypt, Indonesia, and Thailand to expand understanding of the acceptability of NORPLANT contraceptive implants beyond inferences made on the basis of continuation rates. In each of the four study sites, focus group discussions or in-depth interviews were held with potential acceptors, current NORPLANT users, discontinuers, husbands of women in these three groups, and service providers. Nonclinical participants generally had little formal education and lived primarily in urban or semi-urban areas where NORPLANT has been available for at least five years. The study focused on attitudes, perceptions, and experiences of each group regarding NORPLANT implants. Results suggest that factors having an impact on the acceptability of NORPLANT implants fall into three general categories: medical/technical, cultural/religious, and informational/educational. This article discusses each of these categories, including programmatic implications of the findings, and puts forward recommendations for enhancing NORPLANT introduction efforts on the basis of these findings. PMID:2112794

Zimmerman, M; Haffey, J; Crane, E; Szumowski, D; Alvarez, F; Bhiromrut, P; Brache, V; Lubis, F; Salah, M; Shaaban, M

1990-01-01

303

The Case for Pre-K in Education Reform: A Summary of Program Evaluation Findings. Research Series  

ERIC Educational Resources Information Center

For state and federal officials seeking to improve school performance, 50 years of evidence shows that high-quality, voluntary pre-kindergarten is among the best strategies for education reform. This brief from Pew's Pre-K Now initiative highlighted findings from evaluations of state-funded Pre-K programs that continue to document gains in key

Wat, Albert

2010-01-01

304

Rape treatment outcome research: empirical findings and state of the literature.  

PubMed

This article reviews empirical support for treatments targeting women sexually assaulted during adolescence or adulthood. Thirty-two articles were located using data from 20 separate samples. Of the 20 samples, 12 targeted victims with chronic symptoms, three focused on the acute period post-assault, two included women with chronic and acute symptoms, and three were secondary prevention programs. The majority of studies focus on posttraumatic stress disorder (PTSD), depression, and/or anxiety as treatment targets. Cognitive Processing Therapy and Prolonged Exposure have garnered the most support with this population. Stress Inoculation Training and Eye Movement Desensitization and Reprocessing also show some efficacy. Of the four studies that compared active treatments, few differences were found. Overall, cognitive behavioral interventions lead to better PTSD outcomes than supportive counseling does. However, even in the strongest treatments more than one-third of women retain a PTSD diagnosis at post-treatment or drop out of treatment. Discussion highlights the paucity of research in this area, methodological limitations of examined studies, generalizability of findings, and important directions for future research at various stages of trauma recovery. PMID:19442425

Vickerman, Katrina A; Margolin, Gayla

2009-07-01

305

UC Davis researchers find that a double-headed motor protein offers new targets in cancer treatment  

Cancer.gov

The structure of a key part of the machinery that allows cells to divide has been identified by researchers at the University of California, Davis, opening new possibilities for throwing a wrench in the machine and blocking runaway cell division in cancer.

306

Huntsman researchers find that reduced kidney function is associated with higher risk of renal and urothelial cancer  

Cancer.gov

Researchers who investigated the level of kidney function and subsequent cancer risk in more than one million adults have found that reduced glomerular filtration rate is a key measure of reduced kidney function and chronic kidney disease is an independent risk factor for renal and urothelial cancer but not other cancer types.

307

Problems Teachers Face When Doing Action Research and Finding Possible Solutions: Three Cases  

ERIC Educational Resources Information Center

Through case studies, this paper explores problems teachers face when doing action research: for instance, teachers may misunderstand the research, mistrust university researchers, lack the time or adequate library resources to conduct research, lack theoretical guidance or knowledge of research methodology, and feel pressure or frustration during…

Zhou, Jun

2012-01-01

308

What would you like to see/find under "METU Research Highlights"?  

E-print Network

in the nuclear energy sector by promoting civil nuclear research and training activities. Joint Research Centers about the research opportunities, METU Research Highlights comprises the announcements of both national of Atomic Energy Community to contribute to the further consolidation of the European Research Area

Hasýrcý, Vasýf

309

Key Research Results Achievement  

E-print Network

-performance conjugated polymer-fullerene blends used in organic solar cells. Polymer:fullerene blends are popular light-harvesting materials in organic solar cells. Using time-resolved microwave conductivity--a highly sensitive% wastepaper, including 10% post consumer waste. Energetic Barrier Prevents Recombination in Organic Solar

310

NIH Researchers Find Vitamin D Binding Protein May Help to Assess Vitamin D Deficiency in African and White Americans  

MedlinePLUS

NIH researchers find vitamin D binding protein may help to assess vitamin D deficiency in African and white Americans November 21, 2013 Measuring vitamin D binding protein (VDBP) may be important for ...

311

St. Jude researchers find that unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors  

Cancer.gov

St. Jude Children’s Research Hospital study finds that few adult survivors of childhood cancer follow a heart-healthy lifestyle that protects against heart disease, diabetes and other health problems.

312

Research on the effect of noise at different times of day: Models, methods and findings  

NASA Technical Reports Server (NTRS)

Social surveys of residents' responses to noise at different times of day are reviewed. Some of the discrepancies in published reports about the importance of noise at different times of day are reduced when the research findings are classified according to the type of time of day reaction model, the type of time of day weight calculated and the method which is used to estimate the weight. When the estimates of nighttime weights from 12 studies are normalized, it is found that they still disagree, but do not support stronger nighttime weights than those used in existing noise indices. Challenges to common assumptions in nighttime response models are evaluated. Two of these challenges receive enough support to warrant further investigation: the impact of changes in numbers of noise events may be less at night than in the day and nighttime annoyance may be affected by noise levels in other periods. All existing social survey results in which averages of nighttime responses were plotted by nighttime noise levels are reproduced.

Fields, J. M.

1985-01-01

313

Colorectal cancer screening in older men and women: qualitative research findings and implications for intervention.  

PubMed

As part of the formative research for developing interventions to increase colorectal cancer screening in men and women aged 50 and older, 14 focus groups were conducted to identify (1) knowledge, attitudes, and beliefs about colorectal cancer and colorectal cancer screening, (2) barriers to screening, and (3) strategies for motivating and supporting behavior change. Participants had either private insurance or Medicare and reported different levels of experience with colorectal cancer screening. Overall, they were poorly informed about colorectal cancer and the possible benefits of screening, reporting little or no information from physicians or mass media, negative attitudes toward screening procedures, and fear of cancer. Despite references to the subject matter as embarrassing or private, both men and women, African Americans and whites, appeared to talk candidly and comfortably in the permissive context of the focus group. This study's findings suggest that public education campaigns, decision aids, and targeted interventions are urgently needed to put colorectal cancer screening on the public's "radar screen," to increase awareness of the prevention and early detection benefits of screening, and to encourage people 50 and older-and the health care providers who serve them-to make screening a high priority. PMID:10868818

Beeker, C; Kraft, J M; Southwell, B G; Jorgensen, C M

2000-06-01

314

Body image of children and adolescents with cancer: a metasynthesis on qualitative research findings.  

PubMed

Children and adolescents with cancer are confronted with many challenges. This review considered studies that used qualitative methods to examine the body image experience of children and adolescents with cancer. A systematic literature search of English and Chinese databases was undertaken, covering the period between 1960 and October 2010. Qualitative research findings were extracted and pooled using the Joanna Briggs Institute Qualitative Assessment and Review Instrument. Eight papers met the inclusion criteria. The derived four metasyntheses included being distanced from the body, loss of self-identity, self-protective strategies and support, and getting rid of the shackles of the body. In conclusion, children and adolescents with cancer also experience various problems associated with changes in their body image. Repeated courses of treatment lead to loss of a normal, orderly life, and might even result in changes in interpersonal interactions. In response to body image change, individuals with cancer develop self-protective, coping strategies. Children and adolescents who experience life-threatening cancer come to face body image change positively, and might hold a confident attitude toward their future. PMID:22672500

Lee, Mei-Yin; Mu, Pei-Fan; Tsay, Shwu-Feng; Chou, Shin-Shang; Chen, Yu-Chih; Wong, Tai-Tong

2012-09-01

315

Determinants of nursing home costs in Florida: policy implications and support in national research findings.  

PubMed Central

Descriptive and econometric analysis of the major nonquality determinants of nursing home costs for Florida shows that mean costs, size, and occupancy rate increased between 1971 and 1976, that per diem costs and occupancy rate were inversely related, and that the per diem cost was lower in rural than in urban areas. Regression of the data shows that--next to inflation, as expressed by the Consumer Price Index--the occupancy rate accounts for most of the variation in per diem costs, followed by size, urban-rural location, and by type of control. The hypothetical "optimal," defined as lowest cost-size range, was calculated to be more than 350 beds. Recent research substantiates most of these findings. Medicaid Cost Reports from Florida's nursing homes were the source of the information analyzed; by 1976, the sixth year of the study, the data base covered nearly 9 of 10 licensed beds in the State. Some policy implications can be drawn from the analysis. Reductions in per diem costs could be achieved by higher occupancy rates, especially in the larger nursing homes, and a reduction in the rate of inflation would reduce the rate of increase in nursing home costs. PMID:6815706

Traxler, H G

1982-01-01

316

Key issues and challenges in developing a pedagogical intervention in the simulation skills center--an action research study.  

PubMed

Simulation skills centers (SSC) are considered important learning arenas for preparing and qualifying nursing students. Limited clinical placements and claims of diminished learning opportunities raise concerns that newly educated nurses lack proficiency in many psychomotor skills. Accordingly, there is an increased focus on learning in the SSC. However, it has been questioned if the pedagogical underpinning of teaching and learning in the SSC is missing or unclear. At a bachelor nursing education in Norway, there was a desire to change practice and enhance learning in the SSC by systematic use of The Model of Practical Skill Performance (Bjørk and Kirkevold, 2000). A participatory action research design was chosen. A pedagogical intervention was developed and implemented in 2010 in a cohort of eighty-seven first year bachelor nursing students during their basic nursing skill course. The intervention is shortly described. This article reports key issues and challenges that emerged during development of the new intervention. Data to inform the study were collected via thorough meeting minutes and the project leader's logbook, and analyzed using fieldnotes analysis. Six key issues and challenges were identified. These are presented and discussed consecutively in light of their importance for development and implementation of the new intervention. PMID:23642302

Reierson, Inger Åse; Hvidsten, Anne; Wighus, Marianne; Brungot, Solvor; Bjørk, Ida Torunn

2013-07-01

317

Exploring Variations in Teachers' Work, Lives and Their Effects on Pupils: Key Findings and Implications from a Longitudinal Mixed-Method Study  

ERIC Educational Resources Information Center

This article outlines the research design of a large-scale, longitudinal research study in England intended to describe and explore variations in teachers' work, lives and their effects on pupils' educational outcomes. The study, funded by the Department for Education and Skills (DfES) and incorporated into the Teaching and Learning Research

Sammons, Pam; Day, Christopher; Kington, Alison; Gu, Qing; Stobart, Gordon; Smees, Rebecca

2007-01-01

318

What would you like to see/find under "METU Research Highlights"?  

E-print Network

to contribute to the further consolidation of the European Research Area in the nuclear energy sector the research opportunities, METU Research Highlights comprises the announcements of both national tools for research funding opportunities. EURATOM is a funding opportunity of Atomic Energy Community

Hasýrcý, Vasýf

319

What would you like to see/find under "METU Research Highlights"?  

E-print Network

of the Euro- pean Research Area in the nuclear energy sector by promoting civil nuclear research and training about the research op- portunities, METU Research Highlights comprises the announce- ments of both. EURATOM is a funding opportunity of Atomic Energy Com- munity to contribute to the further consolidation

Hasýrcý, Vasýf

320

What would you like to see/find under "METU Research Highlights"?  

E-print Network

consolidation of the Euro- pean Research Area in the nuclear energy sector by promot- ing civil nuclear research the research opportunities, METU Research Highlights comprises the an- nouncements of both national under FP7. EURATOM is a funding opportunity of Atomic Energy Commu- nity to contribute to the further

Hasýrcý, Vasýf

321

Brain, behavior, biology, and music: Some research findings and their implications for educational policy Norman M Weinberger  

E-print Network

Brain, behavior, biology, and music: Some research findings and their implications for educational of publication: Music research is addressed by music educators, experimental psychologists, cognitive scientists Archive (originally named the Music and Brain Information Center). MuSICA is supported by the music

Weinberger, Norman M.

322

Do you find in your own work that there is a gap between service-learning research  

E-print Network

#12;Do you find in your own work that there is a gap between service-learning research and practice service-learning practice? #12;How can we strengthen the connections between service-learning research, Penn State Moderator: Barbara Moely, Tulane #12;Panel participants' work in service- learning

323

Thomas Jefferson University researchers find new biomarker to identify hepatitis B-infected patients at risk for liver cancer  

Cancer.gov

Hepatitis B-infected patients with significantly longer telomeres—the caps on the end of chromosomes that protect our genetic data— were found to have an increased risk of getting liver cancer compared to those with shorter ones, according to findings presented by researchers at Jefferson’s Kimmel Cancer Center at the American Association for Cancer Research (AACR) Annual Meeting 2012.

324

Research findings working with the p53 and Rb1 targeted osteosarcoma mouse model  

PubMed Central

Osteosarcoma (OS) is the most common bone cancer in children and young adults. The etiology of osteosarcoma is currently unknown. Besides the predominant osteoblasts, the presence of cartilage forming chondrocytes within its tumor tissues suggests a role of chondrogenesis in osteosarcoma development. Runx2 is a master transcription factor both for osteoblast differentiation and for chondrocyte maturation. Interestingly, RUNX2 has been shown to directly interact with p53 and Rb1, two genes essential for osteosarcoma development in mice. However the in vivo relevance of Runx2 during osteosarcoma progression has not been elucidated. We have recently shown that targeting Runx2 expression in hypertrophic chondrocytes delays chondrocyte maturation. It has also been shown that osteoblast-specific deletion of p53 and Rb1 genes developed osteosarcoma in mice. Here, we report our recent research findings using these osteosarcoma mouse models as well as human osteosarcoma tissues. We have detected high-level RUNX2 expression in human osteoblastic osteosarcoma, while chondroblastic osteosarcoma is predominant with chondroid matrix. To minimize the effect of strain difference, we have backcrossed osterix-Cre mice onto congenic FVB/N genetic background. We also detected low-GC content (36%) in sequence around the floxed Rb1 gene and demonstrated that addition of BSA into the reaction system increases the efficiency of PCR genotyping of floxed Rb1 gene. Finally, we successfully generated multiple osteosarcoma mouse models with or without Runx2 transgenic background. These mice showed heterogeneous osteosarcoma phenotypes and marker gene expression. Characterization of these mice will facilitate understanding the role of Runx2 in osteosarcoma pathogenesis and possibly, for osteosarcoma treatment. PMID:24959378

Lu, Yaojuan; Gitelis, Steven; Lei, Guanghua; Ding, Ming; Maki, Carl; Mira, Ranim R; Zheng, Qiping

2014-01-01

325

Sanford-Burnham researchers find RNA molecules in urine, tissue that detect prostate cancer  

Cancer.gov

Researchers at Sanford-Burnham Medical Research Institute have identified a set of RNA molecules that are detectable in tissue samples and urine of prostate cancer patients, but not in normal healthy individuals.

326

Kids in Research: Your Child Can Help Find Cures at the NIH Clinical Center  

MedlinePLUS

... Clinical Trials Benefits, Risks & Safety Posters & Flyers Patient Recruitment ResearchMatch Kids in Research Home Register Now Want ... the NIH Clinical Center. This website provides several resources to help determine if ... Page last updated: March 29, 2012

327

Purdue study finds "label-free" imaging tool tracks nanotubes in cells, blood for biomedical research:  

Cancer.gov

Purdue University researchers have demonstrated a new imaging tool for tracking structures called carbon nanotubes in living cells and the bloodstream, which could aid efforts to perfect their use in biomedical research and clinical medicine.

328

Formal Training, Personal Experience, and the Ability to Predict Research Findings in Social Psychology  

Microsoft Academic Search

Researchers in the past have found that personal experience and formal training lead to better accuracy when predicting research outcomes in areas of psychology. Personal experience and formal training were compared in this study on the ability of students to predict research outcomes in social psychology. Students completed questionnaires that measured their social engagement (a proxy to personal experience), their

Carrie Quarterman

2007-01-01

329

The Hermeneutic Dialogic: Finding Patterns midst the "Aporia" of the Artist/Researcher/Teacher.  

ERIC Educational Resources Information Center

This paper considers one researcher's challenge of marking his progress in reading/studying Jacques Derrida's "Aporias" (1993) by what he calls the continual hermeneutic of making meaning. The paper places the "Aporias" reading in the setting of a weekly research group whose research cycle was creating meaning in and out of the work being done and…

de Cosson, Alex

330

Teaching, Learning and Assessing HRD: Findings from a BMAF/UFHRD Research Project  

ERIC Educational Resources Information Center

Purpose: This paper seeks to analyse and explore the results of a research project, which aimed to identify recent and current research on TLA within HRD programmes. From that base the project also intended to identify areas for future research and a basis for establishing a Special Interest Group. Design/methodology/approach: A comprehensive…

Sambrook, Sally; Stewart, Jim

2010-01-01

331

Finding a Canon and Core: Meditations on the Preparation of Teacher Educator-Researchers  

ERIC Educational Resources Information Center

In this article, the author explores seven "unanswered questions" concerning the preparation of future teacher educator-researchers. She considers five questions concerning the substance of doctoral preparation: what the new generation of teacher-researchers would need to know about teacher education, relevant disciplines, research methodologies,…

Wilson, Suzanne M.

2006-01-01

332

Increasing Institutional Research Effectiveness and Productivity: Findings from a National Survey.  

ERIC Educational Resources Information Center

In 1991, a national survey was conducted of institutional research directors at 150 two- and four-year colleges to investigate practitioner perceptions of institutional research effectiveness and productivity. Randomly selected directors of institutional research were mailed a one-page questionnaire, requesting information about institution size…

Huntington, Robin B.; Clagett, Craig A.

333

What would you like to see/find under "METU Research Highlights"?  

E-print Network

to the further consolidation of the Euro- pean Research Area in the nuclear energy sector by promot- ing civil about the research opportunities, METU Research Highlights comprises the an- nouncements of both Commis- sion under FP7. EURATOM is a funding opportunity of Atomic Energy Commu- nity to contribute

Hasýrcý, Vasýf

334

What would you like to see/find under "METU Research Highlights"?  

E-print Network

to the further consolidation of the European Research Area in the nuclear energy sector by promoting civil the research opportunities, METU Research Highlights comprises the announcements of both national Commission under FP7. · EURATOM is a funding opportunity of Atomic Energy Community to contribute

Hasýrcý, Vasýf

335

What would you like to see/find under "METU Research Highlights"?  

E-print Network

to the further consolidation of the European Research Area in the nuclear energy sector by promoting civil about the research opportunities, METU Research Highlights comprises the an- nouncements of both Commission under FP7. EURATOM is a funding opportunity of Atomic Energy Commu- nity to contribute

Hasýrcý, Vasýf

336

On the Relevance of Research Findings in Cognitive Neuroscience to Educational Practice  

Microsoft Academic Search

In their target article, Byrnes and Fox (1998) argue that many of the recent findings from the field of cognitive neuroscience have particular importance for education. In our commentary, we lend support to their contention by reporting on some of our work that has potential relevance to the proposed interface between cognitive neuroscience and education. Specifically, we discuss the findings

Michael W. O'Boyle; Harwant S. Gill

1998-01-01

337

InSITEs into Practitioner Research: Findings from a Research-Based ESOL Teacher Professional Development Programme  

ERIC Educational Resources Information Center

This article describes an innovative continuing professional development (CPD) programme for experienced English for Speakers of Other Languages (ESOL) teachers, and a research study into its impact. The programme incorporates the principles of Practitioner Research (PR) and focuses in particular on the skills of data analysis and situated…

Davis, Matt; Kiely, Richard; Askham, James

2009-01-01

338

Key health outcomes for children and young people with neurodisability: qualitative research with young people and parents  

PubMed Central

Objectives To identify key health outcomes, beyond morbidity and mortality, regarded as important in children and young people with neurodisability, and their parents. Design Qualitative research incorporating a thematic analysis of the data supported by the Framework Approach; the International Classification of Functioning, Disability and Health (ICF) provided a theoretical foundation. Setting The study was conducted in community settings. Participants Participants were 54 children and young people with neurodisability: 50 participated in focus groups, and 4 in interviews; 53 parents participated: 47 in focus groups and 6 in interviews. Children/young people and parents were recruited through different networks, and were not related. Results Children/young people and parents viewed health outcomes as inter-related. Achievement in some outcomes appeared valued to the extent that it enabled or supported more valued domains of health. Health outcomes prioritised by both young people and parents were: communication, mobility, pain, self-care, temperament, interpersonal relationships and interactions, community and social life, emotional well-being and gaining independence/future aspirations. Parents also highlighted their child's sleep, behaviour and/or safety. Conclusions Those responsible for health services for children/young people with neurodisability should take account of the aspects of health identified by families. The aspects of health identified in this study provide a basis for selecting appropriate health indicators and outcome measures. PMID:24747792

Allard, Amanda; Fellowes, Andrew; Shilling, Valerie; Janssens, Astrid; Beresford, Bryony; Morris, Christopher

2014-01-01

339

Trying to compensate. Latest ranking of CEO compensation finds stock options still key to pay as experts monitor for effects of SEC rule changes.  

PubMed

Despite past outcries from critics, stock options continue to play a starring, albeit smaller, role in compensation for CEOs at top companies, based on research by accounting professor Steven Balsam, left. Read about the 30 healthcare executives who brought home the biggest pay packages in our annual ranking of CEOs' compensation. PMID:17824144

Galloro, Vince; Vesely, Rebecca; Zigmond, Jessica

2007-07-30

340

Socio?cultural dynamics of female genital cutting: Research findings, gaps, and directions  

Microsoft Academic Search

The goal of abolishing female genital cutting (FGC, or also FGM or ‘female circumcision’) requires that the socio?cultural dynamics of the practice be well understood if behavioural change is to be accomplished. This paper, based on the literature and the author's ethnographic research in Sudan, reports on the research issues of studying the variation in and complexity of cutting practices

Ellen Gruenbaum

2005-01-01

341

Roswell Park-led study finds most cancer research trials do not assess participants’ tobacco use  

Cancer.gov

While tobacco use can significantly hamper cancer treatment, few cancer researchers are incorporating tobacco assessment into their clinical studies. That’s the conclusion a group of investigators led by researchers at Roswell Park Cancer Institute drew from a recent survey of cancer clinical trials.

342

Research foci for career and technical education: findings from a national Delphi study  

E-print Network

for relevant and focused research for the CTE profession. The primary purpose of this study was to identify consensus among CTE experts using a Delphi technique regarding problems, objectives, and activities that serve as a research agenda for CTE. The study...

Lambeth, Jeanea Marie

2009-05-15

343

Evaluation of the NSF Industry/University Cooperative Research Centers: Descriptive and Correlative Findings.  

ERIC Educational Resources Information Center

This report presents results of a survey of participants in the National Science Foundation (NSF) Industry-University Cooperative Research Centers program. The program promotes more rapid technological innovation by creating linkages between industry and university scientists. The Centers function as university research groups, with partial…

National Science Foundation, Washington, DC. Directorate for Engineering.

344

Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science  

Microsoft Academic Search

BACKGROUND: Many interventions found to be effective in health services research studies fail to translate into meaningful patient care outcomes across multiple contexts. Health services researchers recognize the need to evaluate not only summative outcomes but also formative outcomes to assess the extent to which implementation is effective in a specific setting, prolongs sustainability, and promotes dissemination into other settings.

Laura J Damschroder; David C Aron; Rosalind E Keith; Susan R Kirsh; Jeffery A Alexander; Julie C Lowery

2009-01-01

345

What They Take with Them: Findings from the Peer Writing Tutor Alumni Research Project  

ERIC Educational Resources Information Center

Through the Peer Writing Tutor Alumni Research Project (PWTARP), the authors have set out to explore and document what peer tutors take with them from their training and experience. The Peer Writing Tutor Alumni Research Project has made it possible for the authors to sample and analyze more systematically the reflections of 126 former tutors from…

Hughes, Bradley; Gillespie, Paula; Kail, Harvey

2010-01-01

346

Overhead Rates for Federal Research Are as High as Ever, Survey Finds.  

ERIC Educational Resources Information Center

Despite pressure from Congress and faculty, and a series of revisions in federal regulations, the average rate charged the government by universities for overhead for federally financed research appears remains high. Average rate for the top 100 research institutions is over 50%; most of the highest rates are at private institutions; all the…

Cordes, Colleen

1998-01-01

347

6- Homeless Youth in the United States: Recent Research Findings and Intervention Approaches  

Microsoft Academic Search

In this paper, the authors cite research indicating that youth may be the single age group most at risk of becoming homeless, yet comparatively little research has been done in the past decade on this vulnerable population. Some important progress has been made, including longitudinal studies on youth \\

Paul A. Toro; Amy Dworsky; Patrick J. Fowler

348

UC Irvine researchers find a cause of chemotherapy resistance in melanoma  

Cancer.gov

Researchers with UC Irvine’s Chao Family Comprehensive Cancer Center have identified a major reason why melanoma is largely resistant to chemotherapy. The researchers found a genetic pathway in melanoma cells that inhibits the cellular mechanism for detecting DNA damage wrought by chemotherapy, thereby building up tolerance to cancer-killing drugs.

349

Returning incidental findings from genetic research to children: views of parents of children affected by rare diseases  

PubMed Central

Purpose To explore parental perceptions and experiences regarding the return of genomic incidental research findings in children with rare diseases. Methods Parents of children affected by various rare diseases were invited to participate in focus groups or individual telephone interviews in Montreal and Ottawa. Fifteen participants were interviewed and transcriptions were analysed using thematic analysis. Results Four emergent themes underscored parental enthusiasm for receiving incidental findings concerning their child's health: (1) right to information; (2) perceived benefits and risks; (3) communication practicalities: who, when, and how; and (4) service needs to promote the communication of incidental findings. Parents believed they should be made aware of all results pertaining to their child's health status, and that they are responsible for transmitting this information to their child, irrespective of disease severity. Despite potential negative consequences, respondents generally perceived a favourable risk-benefit ratio in receiving all incidental findings. Conclusions Understanding how parents assess the risks and benefits of returning incidental findings is essential to genomic research applications in paediatric medicine. The authors believe the study findings will contribute to establishing future best practices, although further research is needed to evaluate the impact of parental decisions on themselves and their child. PMID:24356209

Kleiderman, Erika; Knoppers, Bartha Maria; Fernandez, Conrad V; Boycott, Kym M; Ouellette, Gail; Wong-Rieger, Durhane; Adam, Shelin; Richer, Julie; Avard, Denise

2014-01-01

350

New findings and a new species of the genus Ammothea (Pycnogonida, Ammotheidae), with an updated identification key to all Antarctic and sub-Antarctic species  

NASA Astrophysics Data System (ADS)

Specimens of the pycnogonid genus Ammothea collected during the Polarstern cruise XXIII/8 (23 November 2006-30 January 2007) were studied. Nine species were recognized in this collection: Ammothea bentartica, A. bicorniculata, A. carolinensis, A. clausi, A. longispina, A. minor, A. spinosa, A. striata and A. tibialis. Three of them ( A. bentartica, A. bicorniculata and A. tibialis) are reported for the second time, enlarging their known geographical and bathymetric range. In the present contribution, the observed morphological variability of all collected Ammothea species is described and discussed. For the identification and description of the material, different museum specimens were consulted. Among them, we have consulted part of the Discovery collection housed at the Natural History Museum in London. That material was initially identified by Isabella Gordon, a reputed author in the field of pycnogonid taxonomy. A new species, based on a museum specimen previously highly confused in the literature, is proposed in the present contribution as Ammothea isabellae n. sp. The new taxon is compared with its closest congeners, especially with A. longispina and A. stylirostris. Finally, we propose an updated dichotomous key to species covering all currently known Antarctic and sub-Antarctic Ammothea species.

Cano-Sánchez, E.; López-González, P. J.

2014-03-01

351

Emerging Answers: Research Findings on Programs to Reduce Teen Pregnancy (Summary)  

NSDL National Science Digital Library

Released on May 30, 2001, by the National Campaign to Prevent Teen Pregnancy, this new report by Dr. Douglas Kirby reviews some 250 studies on teen pregnancy programs. The review finds that long-term programs have made a genuine difference in teen pregnancy, abortion, and birth rates, the last of which is now at its lowest level recorded. Kirby's study also finds no evidence that "abstinence-only" programs are effective or that sex education that covers contraception increases sexual activity. At the site, visitors may download a 21-page summary of the report, the press release, a FAQ, and related information.

Kirby, Douglas

2001-01-01

352

Moffitt researchers find potential new therapeutic target for treating non-small cell lung cancer  

Cancer.gov

Researchers at Moffitt Cancer Center have found a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer. It is based on the newly identified oncogene IKBKE, which helps regulate immune response.

353

Columbia University researchers find that Blacks and Hispanics are at higher risk for precancerous colorectal polyps  

Cancer.gov

Blacks and Hispanics have a significantly higher risk of developing precancerous colorectal polyps compared with whites, according to a study by researchers at New York Presbyterian Hospital/Columbia University Medical Center.

354

U of Pittsburgh researchers potentially find a better way to track emerging cell therapies using MRIs  

Cancer.gov

Researchers describe the first human tests of using a perfluorocarbon (PFC) tracer in combination with non-invasive magnetic resonance imaging (MRI) to track therapeutic immune cells injected into patients with colorectal cancer.

355

Duke researchers find that prostate cancer’s penchant for copper may be a fatal flaw  

Cancer.gov

Researchers at Duke Medicine have found a way to kill prostate cancer cells by delivering a trove of copper along with a drug that selectively destroys the diseased cells brimming with the mineral, leaving non-cancer cells healthy.

356

Columbia U researchers find that generic medications boost adherence to breast cancer therapy  

Cancer.gov

A study by Columbia University Medical Center researchers has found that the introduction of generic aromatase inhibitors, which are considerably less expensive than their brand-name counterparts, increased treatment adherence by 50 percent.

357

UTHSC researchers find that improved screening means new targets for pediatric neuroblastoma therapies  

Cancer.gov

A researcher at the University of Texas Health Science Center at San Antonio unveils the important role of microRNAs in regulating neuroblastoma development, pointing to new therapeutic possibilities.

358

Harvard and Baylor researchers find new target for aggressive cancer gene:  

Cancer.gov

Researchers have found a way to kill human cells hijacked by a genetic accelerator that puts cancer cells into overdrive: the Myc oncogene. The discovery reveals new drug targets for Myc-driven cancers, which tend to be particularly aggressive.

359

UCLA researchers develop new screening system to find brain cancer stem cell killers:  

Cancer.gov

Researchers with UCLA’s Jonsson Comprehensive Cancer Center have developed and used a high-throughput molecular screening approach that identifies and characterizes chemical compounds that can target the stem cells that are responsible for creating deadly brain tumors.

360

Albert Einstein researchers find that a chemical stem cell signature predicts treatment response for AML  

Cancer.gov

Researchers at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center have found a chemical “signature” in blood-forming stem cells that predicts whether patients with acute myeloid leukemia will respond to chemotherapy.

361

UCLA researchers find intestinal bacteria are linked to white blood cell cancer  

Cancer.gov

Researchers from UCLA's Jonsson Comprehensive Cancer Center have discovered that specific types of bacteria that live in the gut are major contributors to lymphoma, a cancer of the white blood cells that are part of the human immune system.

362

Duke researchers find that combining treatments boosts some smokers’ ability to quit  

Cancer.gov

Combining two smoking cessation therapies is more effective than using just one for male and highly nicotine-dependent smokers who weren't initially helped by the nicotine patch, according to researchers at Duke Medicine.

363

UCSF researchers find that a sugary coating on cells may drive aggressive cancers  

Cancer.gov

A research team led by UC San Francisco scientists has shown that cancer-induced structural changes in a sugary coating ensheathing cells can promote mechanical interactions that fuel tumor growth and metastasis.

364

Dana-Farber researchers find that marker may predict response to ipilimumab in advanced melanoma  

Cancer.gov

Dana-Farber researchers found that in patients with advanced melanoma using the immunotherapy ipilimumab, presence of higher levels of the protein VEGF in the blood was associated with a poorer response.

365

Problem solving and creativity for undergraduate engineers: findings of an action research project involving robots  

Microsoft Academic Search

Many researchers have written about the importance and complexities of developing problem solving skills and encouraging creative thinking in engineering students. Research continues to suggest deficiencies in developing or assessing process skills; with the attention of engineering educators being on outcomes or products of problem solving scenarios.\\u000d\\u000aThis paper considers highlights of this previous work, and how this might inform

J. P. Adams; S. Turner; S. Kaczmarczyk; P. Picton; P. Demian

2008-01-01

366

Turning a negative into a positive: Researchers find promising use for excessive nitrate  

E-print Network

for excessive nitrate For 30 years, farmers in northwest central Texas have known that high level of nitrates in irrigation water from the Seymour Aquifer is a problem. Now, with research conducted by Texas AgriLife Research scientists, that problem may... turn into a benefit. Nitrate is the most common chemical con- taminant in groundwater. For the Seymour, a shallow aquifer underlying about 300,000 acres in 20 counties, more than 50 percent of groundwater nitrate measurements exceed the federal...

Wythe, Kathy

2009-01-01

367

Alternate Methods for Assuring Credibility of Research and Evaluation Findings in Project Evaluation.  

ERIC Educational Resources Information Center

This paper describes six existing evaluator-auditor working formats and the conditions which foster credibility of evaluation findings. Evaluators were classified as: (1) member of project developmental team, accountable to project director; (2) independent internal evaluator, accountable to system in general but not to project directors, and (3)…

Denton, William T.; Murray, Wayne R.

368

The Kindergarten Screening Program: Research Findings and Related Issues 1986-87.  

ERIC Educational Resources Information Center

Studies were conducted locally to augment findings from the literature regarding the effect of school entrance age, and to examine several other issues related to the St. Louis Public School's kindergarten screening program. Studies reported address a number of questions related to program planning and policy development: (1) Is there evidence to…

Saint Louis Public Schools, MO. Div. of Evaluation and Research.

369

Conclusions: Overview of Findings from the ERA Study, Inferences, and Research Implications  

ERIC Educational Resources Information Center

In this monograph, the authors have brought the findings of the English and Romanian Adoptee (ERA) study up to age 15 years and, in so doing, have focused especially on the question of whether there are deprivation-specific psychological patterns (DSPs) that differ meaningfully from other forms of psychopathology. For this purpose, their main…

Rutter, Michael; Sonuga-Barke, Edmund J.

2010-01-01

370

Findings on Brain MRI from Research Studies of Occupational Exposure to Known Neurotoxicants  

Microsoft Academic Search

OBJECTIVE. The expanding use of MRI in large-scale epidemiologic studies of CNS out- comes has led to increasing concern for the consistent handling of incidental findings. Our pur- pose is to identify the prevalence of incidental neuroradiologic abnormalities in an adult pop- ulation with past occupational exposure to lead who underwent brain MRI as part of a large, longitudinal cohort

Hannah H. Alphsr; Brian S. Schwartz; Walter F. Stewart; David M. Yousema; Alphs HH; Schwartz BS; Stewart WF; Yousem DM

371

Fox Chase researchers find that most Medicare patients wait weeks before breast cancer surgery  

Cancer.gov

Although patients may feel anxious waiting weeks from the time of their first doctor visit to evaluate their breast until they have breast cancer surgery, new findings from Fox Chase Cancer Center show that these waits are typical in the United States. Results were published on Monday, November 19 in the Journal of Clinical Oncology.

372

Operations Research Time Line 1665 Newton's Method for Finding a Minimum Solution of a Function, I. Newton  

E-print Network

Probability Theory and Its Engineering Uses, T. C. Fry 1930 Econometric Society founded 1931 Quality Control Evaluation Group (OEG) 1950 Military Gaming 1950 An Introduction to Probability Theory and Its ApplicationsOperations Research Time Line 1665 Newton's Method for Finding a Minimum Solution of a Function, I

Gomes, Carla P.

373

Bonus Awards for Teachers in Texas' Performance Pay Program: Findings from the First Round of TEEG Schools. Research Brief  

ERIC Educational Resources Information Center

A recent report published by the National Center on Performance Incentives (NCPI) presents findings from the second-year of a multi-year evaluation of the Texas Educator Excellence Grant (TEEG) program, a statewide educator incentive program that operated in Texas. As part of this evaluation report, researchers examined how first-year TEEG schools…

National Center on Performance Incentives, 2009

2009-01-01

374

Statement Summarizing Research Findings on the Issue of the Relationship Between Food-Additive-Free Diets and Hyperkinesis in Children.  

ERIC Educational Resources Information Center

The National Advisory Committee on Hyperkinesis and Food Additives paper summarized some research findings on the issue of the relationship between food-additive-free diets and hyperkinesis in children. Based on several challenge studies, it is concluded that the evidence generally refutes Dr. B. F. Feingold's claim that artificial colorings in…

Lipton, Morris; Wender, Esther

375

Experiences of racism and discrimination among migrant care workers in England: Findings from a mixed-methods research project  

Microsoft Academic Search

This article reports part of the findings of research undertaken between 2007 and 2009 that aimed to investigate the contribution made by migrant workers to the care workforce in England. The study involved analysis of national statistics on social care and social workers and semi-structured interviews with a wide range of stakeholders, including ninety six migrant care workers. The interviews

Martin Stevens; Shereen Hussein; Jill Manthorpe

2011-01-01

376

UC Davis researchers find oropharyngeal cancer patients with HPV have a more robust response to radiation therapy  

Cancer.gov

UC Davis cancer researchers have discovered significant differences in radiation-therapy response among patients with oropharyngeal cancer depending on whether they carry the human papillomavirus (HPV), a common sexually transmitted virus. The findings, published online today in The Laryngoscope Journal, could lead to more individualized radiation treatment regimens, which for many patients with HPV could be shorter and potentially less toxic.

377

World Bank: Harnessing civil society expertise in undertaking and disseminating research findings  

PubMed Central

The UK Consortium on AIDS and International Development was an essential partner to the evaluation leaders in harnessing the contribution and expertise of civil society. This article describes what the partnership entailed, the additional value it brought and how civil society might use the evaluation findings both as a tool for advocacy and a means for improving its own engagement with the individuals directly affected by HIV and with those who care for them. PMID:23745623

Simms, Ben

2013-01-01

378

Procedures of recruiting, obtaining informed consent, and compensating research participants in Qatar: findings from a qualitative investigation  

PubMed Central

Background Very few researchers have reported on procedures of recruiting, obtaining informed consent, and compensating participants in health research in the Arabian Gulf Region. Empirical research can inform the debate about whether to adjust these procedures for culturally diverse settings. Our objective was to delineate procedures related to recruiting, obtaining informed consent, and compensating health research participants in the extremely high-density multicultural setting of Qatar. Methods During a multistage mixed methods project, field observations and qualitative interviews were conducted in a general medicine clinic of a major medical center in Qatar. Participants were chosen based on gender, age, literacy, and preferred language, i.e., Arabic, English, Hindi and Urdu. Qualitative analysis identified themes about recruitment, informed consent, compensation, and other research procedures. Results A total of 153 individuals were approached and 84 enrolled; the latter showed a diverse age range (18 to 75 years); varied language representation: Arabic (n?=?24), English (n?=?20), Hindi (n?=?20), and Urdu (n?=?20); and balanced gender distribution: women (n?=?43) and men (n?=?41). Primary reasons for 30 declinations included concern about interview length and recording. The study achieved a 74% participation rate. Qualitative analytics revealed key themes about hesitation to participate, decisions about participation with family members as well as discussions with them as “incidental research participants”, the informed consent process, privacy and gender rules of the interview environment, reactions to member checking and compensation, and motivation for participating. Vulnerability emerged as a recurring issue throughout the process among a minority of participants. Conclusions This study from Qatar is the first to provide empirical data on recruitment, informed consent, compensation and other research procedures in a general adult population in the Middle East and Arabian Gulf. This investigation illustrates how potential research participants perceive research participation. Fundamentally, Western ethical research principles were applicable, but required flexibility and culturally informed adaptations. PMID:24495499

2014-01-01

379

Informed consent for exome sequencing research in families with genetic disease: The emerging issue of incidental findings.  

PubMed

Genomic sequencing technology is increasingly used in genetic research. Studies of informed consent for exome and genome sequencing (ES/GS) research have largely involved hypothetical scenarios or healthy individuals enrolling in population-based studies. Studies have yet to explore the consent experiences of adults with inherited disease. We conducted a qualitative interview study of 15 adults recently enrolled in a large-scale ES/GS study (11 affected adults, four parents of affected children). Our study had two goals: (1) to explore three theoretical barriers to consent for ES/GS research (interpretive/technical complexity, possibility of incidental findings, and risks of loss of privacy); and (2) to explore how interviewees experienced the consent process. Interviewees could articulate study goals and processes, describe incidental findings, discuss risks of privacy loss, and reflect on their consent experience. Few expected the study would identify the genetic cause of their condition. All elected to receive incidental findings. Interviewees acknowledged paying little attention to potential implications of incidental findings in light of more pressing goals of supporting research regarding their own medical conditions. Interviewees suggested that experience living with a genetic condition prepared them to adjust to incidental findings. Interviewees also expressed little concern about loss of confidentiality of study data. Some experienced the consent process as very long. None desired reconsent prior to return of study results. Families with inherited disease likely would benefit from a consent process in which study risks and benefits were discussed in the context of prior experiences with genetic research and genetic disease. © 2014 Wiley Periodicals, Inc. PMID:25251809

Bergner, Amanda L; Bollinger, Juli; Raraigh, Karen S; Tichnell, Crystal; Murray, Brittney; Blout, Carrie Lynn; Telegrafi, Aida Bytyci; James, Cynthia A

2014-11-01

380

Designing for Dissemination Among Public Health Researchers: Findings From a National Survey in the United States  

PubMed Central

Objectives. We have described the practice of designing for dissemination among researchers in the United States with the intent of identifying gaps and areas for improvement. Methods. In 2012, we conducted a cross-sectional study of 266 researchers using a search of the top 12 public health journals in PubMed and lists available from government-sponsored research. The sample involved scientists at universities, the National Institutes of Health, and the Centers for Disease Control and Prevention in the United States. Results. In the pooled sample, 73% of respondents estimated they spent less than 10% of their time on dissemination. About half of respondents (53%) had a person or team in their unit dedicated to dissemination. Seventeen percent of all respondents used a framework or theory to plan their dissemination activities. One third of respondents (34%) always or usually involved stakeholders in the research process. Conclusions. The current data and the existing literature suggest considerable room for improvement in designing for dissemination. PMID:23865659

Jacobs, Julie A.; Tabak, Rachel G.; Hoehner, Christine M.; Stamatakis, Katherine A.

2013-01-01

381

Attitudes Towards Migrants and Needs in Teacher Training : Some Research Findings  

Microsoft Academic Search

The area of immigrant education has become a major source of interest, concern, comment, and research in recent years. This interest has its origins in the concern felt and views expressed at various conferences that many pupils in our schools are in need of an educational approach which will take cognisance of their linguistic and cultural differences.

R. W. Sealey

1980-01-01

382

Northwestern researchers find lower dosage CT-guided lung biopsy protocol maintains quality, minimizes exposure  

Cancer.gov

New guidelines for CT-guided biopsies of lung nodules significantly reduce radiation exposure allowing individuals the benefit of the procedure, which may cut down on overall lung cancer deaths. This research is being presented at the Society of Interventional Radiology's 37th Annual Scientific Meeting in San Francisco, Calif.

383

The Quality of Schools and Instruction-Empirical Findings on Problems and Prospects of Research.  

ERIC Educational Resources Information Center

Examines unresolved problems and future prospects for research concerning school quality. Asserts that the proportion of variance among factors such as, school system, school type, grade levels, individual schools, and learning groups makes consideration of the schools as a homogenous whole doubtful. Includes numerous statistical tables and…

Ditton, Hartmut; Krecker, Lothar

1995-01-01

384

Standardization in EU Education and Training Policy: Findings from a European Research Network  

ERIC Educational Resources Information Center

This paper describes an EU-funded project under the Training and Mobility of Researchers (TMR) Programme, with a particular emphasis on the Oxford-based part. Involving six European universities, the overarching investigation was concerned with the tensions between standardization and tradition in education. In Oxford the focus was on aspects of…

Ertl, Hubert; Phillips, David

2006-01-01

385

Penn researchers find Epstein Barr-like virus infects and may cause cancer in dogs  

Cancer.gov

...A team of researchers from the University of Pennsylvania School of Veterinary Medicine and Penn's Perelman School of Medicine has the first evidence that an Epstein Barr-like virus can infect and may also be responsible for causing lymphomas in man's best friend.

386

UCSD researchers find that chili peppers may inhibit gut tumors in mice  

Cancer.gov

Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin – the active ingredient in chili peppers – produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal tumors.

387

Georgetown researchers find higher estrogen production in the breast could confer greater cancer risk than thought:  

Cancer.gov

Could some women who naturally produce excess aromatase in their breasts have an increased risk of developing breast cancer? Results of a new animal study suggests that may be the case, say researchers at Georgetown Lombardi Comprehensive Cancer Center, a part of Georgetown University Medical Center.

388

Social and Emotional Distress among American Indian and Alaska Native Students: Research Findings. ERIC Digest.  

ERIC Educational Resources Information Center

Many American Indian and Alaska Native (AI/AN) youth are repeatedly exposed to opportunities to participate in self-destructive and illegal behaviors. This digest examines risk factors associated with four contexts: peers, family, school, and community. Recent research has shown that, relative to national averages, AI/AN youth have higher rates of…

Clarke, Ardy SixKiller

389

Fostering Change from Without: A Practical Perspective. Getting Innovative Practices Into Schools: Related Research Findings.  

ERIC Educational Resources Information Center

Attempts to answer the question "What does research say about getting innovations into schools?" are based on the experiences of a nonprofit organization that has been engaged in staff development efforts to bring about change in schools. The paper presents a general description of the organization's operation; its relationship to other change…

Crandall, David P.; Harris, Richard C.

390

ICT and Project-Based Education: Some Findings from an Exploratory Research Study  

Microsoft Academic Search

This paper contributes to the discussion on information and communication technology (ICT) for educational purposes. Research was done on the use a virtual learning environment (VLE) based on Internet technology during a practical course for economic students at the Vrije Universiteit Amsterdam. The VLE has been used for many dtferent purposes such as to support team learning, to inform students

Marleen Huysman; Han Gerrits

1998-01-01

391

Fox Chase researchers find that targeted therapy extends progression-free survival for advanced ovarian cancer:  

Cancer.gov

A new Phase 3 clinical trial conducted by the Gynecologic Oncology Group showed that a targeted therapy called bevacizumab (Avastin) effectively delayed the progression of advanced ovarian cancer. Patients with newly diagnosed advanced ovarian cancer now typically undergo surgery and chemotherapy, but the new research suggests an additional avenue of treatment.

392

Strategies for Improving Rehearsal Technique: Using Research Findings to Promote Better Rehearsals  

ERIC Educational Resources Information Center

Music education researchers and conducting pedagogues have identified numerous behaviors that contribute to increased verbal and nonverbal teaching effectiveness of conductors on the podium. This article is a review of literature concerning several conductor behaviors that may (a) increase the effectiveness of rehearsals, (b) enhance the…

Silvey, Brian A.

2014-01-01

393

The Meaning of Work Among Chinese University Students: Findings From Prototype Research Methodology  

Microsoft Academic Search

This study examined Chinese university students' conceptualization of the meaning of work. One hundred and ninety students (93 male, 97 female) from Beijing, China, participated in the study. Prototype research methodology (J. Li, 2001) was used to explore the meaning of work and the associations among the identified meanings. Cluster analysis was used to organize the identified meanings into a

Sili Zhou; S. Alvin Leung; Xu Li

2012-01-01

394

UNC and other researchers find that gene expression improves the definition of a breast cancer subtype  

Cancer.gov

A study conducted by the Vall d'Hebron Institute of Oncology in conjunction with the GEICAM cooperative group and other American and Canadian researchers, including UNC, has led to a change in the definition of hormone-sensitive breast tumors

395

UCSF researchers find that longer telomeres could be linked to risk of brain cancer  

Cancer.gov

New genomic research led by UC San Francisco scientists reveals that two common gene variants that lead to longer telomeres, the caps on chromosome ends thought by many scientists to confer health by protecting cells from aging, also significantly increase the risk of developing the deadly brain cancers known as gliomas.

396

Finding Tomorrow's Cures Northwestern University Plans for a Medical Research Facility  

E-print Network

Prentice Women's Hospital, 320 E. Huron Street. at site is the linchpin for the combined plans that attracts innovation and entrepreneurship. Construction of the new research facility on the Prentice site-of-the- art in its con guration. Innovation and entrepreneurship can happen in Chicago, just as they do

Contractor, Anis

397

Finding God in Wellworth High School: More Legitimations of Story-Making as Research  

ERIC Educational Resources Information Center

A curious piece of ironic, partially-dramatised auto/ethnography, this paper reflects an ongoing attempt to explore the vapid certainties of my own faith, some of the brittle discomforts of contemporary schooling, and the possibilities of a social science research methodology which can artfully assemble on the same stage belief, empirics and…

Clough, Peter

2009-01-01

398

A serendipitous finding of a news media history effect: A research note  

Microsoft Academic Search

On January 16, 1989, a Hispanic Miami police officer shot and killed a black motorcyclist in a predominantly black section of Miami. During the following week, the shooting and its aftermath received extensive newspaper, television, and radio coverage. In criminal justice research, history effects are a common concern but empirical demonstrations are rarely reported. As part of a larger study

Ray Surette

1995-01-01

399

Adults' Informal Learning: Definitions, Findings, Gaps, and Future Research. NALL Working Paper #21.  

ERIC Educational Resources Information Center

This paper on adult informal learning is divided into four sections. Section 1 examines different conceptions of informal learning and the issues and limitations associated with alternative definitions of informal learning. Section 2 is a review of empirical research on the estimated extent, role, and outcomes of informal learning and posited…

Livingstone, D. W.

400

Fatigue Issues for Metropolitan Bus Drivers: Ramifications of Quantitative & Qualitative Research Findings for Safety Management  

Microsoft Academic Search

Metropolitan bus drivers operating in urban areas are exposed daily to a stressful and distracting work environment. To date, there has been a dearth of research exploring whether these factors cause fatigue in this population. The present study aimed to provide insight into metropolitan bus driver fatigue. The study was conducted in two phases. Firstly, focus groups were held at

H. C. Biggs

401

Understanding resistance to sex and race-based affirmative action: A review of research findings  

Microsoft Academic Search

The public discussion of affirmative action appears to be complicated by disagreements regarding definitions and by the lack of a theoretical framework from which to begin to understand this complex public policy. The present review attempts to synthesize the available research into a model from which resistance to affirmative action can be understood. Within the model, resistance to affirmative action

Kelli Cook

1995-01-01

402

Finding the Right Path: Researching Your Way to Discovery. Professional Growth Series.  

ERIC Educational Resources Information Center

Intended for use by teachers, librarians, parents, and elementary school students, this book provides 115 pathfinders to a variety of subjects to guide a student's research and broaden a child's interest base. Each pathfinder (i.e., collection of resources on a given topic) includes: a description of the subject; the Dewey Decimal numbers specific…

Sutter, Lynne; Sutter, Herman

403

Domestic Violence Between Same-Gender Partners: Recent Findings and Future Research  

ERIC Educational Resources Information Center

Empirical literature about same-gender domestic violence was relatively nonexistent until the past 20 years, and conducting research with this population about a sensitive topic remains a daunting endeavor. Existing studies reveal similarities between opposite- and same-gender domestic violence in prevalence, types of abuse, and various dynamics,…

McClennen, Joan C.

2005-01-01

404

The importance of the repressive coping style: findings from 30 years of research  

Microsoft Academic Search

During the last three decades there has been substantial research exploring the repressive coping style as defined by Weinberger, Schwartz, and Davidson. As “repressors,” who score low on trait anxiety and high on defensiveness, account for up to 50% of certain populations, they are an essential group for psychologists to study. However, there are methodological issues in identifying repressors as

Lynn B. Myers

2010-01-01

405

Georgetown researchers examine nipple sparing mastectomy cases and find no recurrent or new cancers:  

Cancer.gov

A new study suggests some women needing a lumpectomy or mastectomy to treat their breast cancer have another potential option that is safe and effective, say researchers at Georgetown. They say the procedure known as a nipple sparing mastectomy is also a viable surgical option for women who choose to have their breasts removed because of their increased risk of developing the disease.

406

The Hermeneutic Dialogic: Finding Patterns amid the Aporia of the Artist/Researcher/Teacher.  

ERIC Educational Resources Information Center

Art learning is an embodied practice learned through praxis. An unconventional style of conducting research on such learning is presented, in which doing the work changes the intent, which in turn changes the work, subsequently changing the intent again, and so on. The process leads to discovery and new insights. (TD)

de Cosson, Alex

2002-01-01

407

The ABCs of Keeping on Track to Graduation: Research Findings from Baltimore  

ERIC Educational Resources Information Center

This study of graduation outcomes in Baltimore uses multivariate analysis of longitudinal student cohort data to examine the impact of factors identified in previous research as early warning indicators of a dropout outcome. Student cohort files were constructed from longitudinal administrative data (following all first-time 2004-2005 and…

Mac Iver, Martha Abele; Messel, Matthew

2013-01-01

408

Baseline personality comparisons between astronauts and Antarctic personnel: Implications for generalization of psychological research findings  

Microsoft Academic Search

This paper presents a review of personality research conducted by investigators at The University of Texas at Austin and the University of Bergen. Over the past several years, personality data have been collected on active duty NASA astronauts (N=66), final stage astronaut applicants (N=259), Australian Antarctic station personnel (N=111) and Norwegian polar scientists (N=34). Analyses of the astronaut data have

David M. Musson; M. Sandal

409

Better Together: Research Findings on the Relationship between Racial Justice Organizations and LGBT Communities. Report  

ERIC Educational Resources Information Center

In partnership with the Arcus Foundation, the Applied Research Center (ARC) has undertaken a study of the relationship between racial justice organizations and lesbian/gay/bisexual/transgender (LGBT) constituencies and issues, with the understanding that communities of color themselves, including their LGBT members, have a good deal at stake in…

Sen, Rinku; Wessler, Seth; Apollon, Dominique

2010-01-01

410

Finding Voice through Teacher-Student Collaboration in a Feminist Research Project: Long-Term Effects.  

ERIC Educational Resources Information Center

In a feminist classroom an instructor who acts as an "interested party" rather than an authority, fosters an environment of care and connection which can result in life-changing discoveries for the participants. Drawing on David Bleich's conception of a "socially generous research" that removes hierarchical barriers between teacher and student, a…

Fey, Marion Harris

411

Hopkins researchers find that blood test for 'nicked' protein predicts prostate cancer treatment response  

Cancer.gov

Prostate cancer patients whose tumors contain a shortened protein called AR-V7, which can be detected in the blood, are less likely to respond to two widely used drugs for metastatic prostate cancer, according to results of a study led by researchers at the Johns Hopkins Kimmel Cancer Center.

412

Main Findings and Policy Implications from the Research Project Public Perceptions of Mountain Forests in Switzerland  

Microsoft Academic Search

The research project was carried out in order to obtain more knowledge of the attitudes of people living in the mountain areas of Switzerland towards forests, forestry and forest politics. A questionnaire was sent to 2160 private individuals and 72 communal councillors responsible for the forest in their own communes. It contained both questions which the respondents were asked to

Zimmermann Willi; Wild-Eck Stephan

413

Georgetown researchers find that landmark Medicare law had little impact on reducing chemotherapy cost  

Cancer.gov

Legislation passed in 2003 to slow the spiraling costs of drugs paid for by the federal government to treat Medicare patients has had no meaningful impact on cancer chemotherapy drug costs, say a team of researchers in the Journal of Clinical Oncology published online today.

414

Washington University researchers find that mass prostate cancer screenings don’t reduce death:  

Cancer.gov

There’s new evidence that annual prostate cancer screening does not reduce deaths from the disease, even among men in their 50s and 60s and those with underlying health conditions, according to new research led by Washington University School of Medicine in St. Louis.

415

Jefferson researchers find that cancer information on Wikipedia is accurate, but not very readable:  

Cancer.gov

It is a commonly held that information on Wikipedia should not be trusted, since it is written and edited by non-experts without professional oversight. But researchers from the Kimmel Cancer Center at Jefferson have found differently, according to a study published online Sept. 15 in the Journal of Oncology Practice.

416

Kimmel Cancer Center researchers find drugs targeting chromosomal instability may fight a particular breast cancer subtype  

Cancer.gov

A team of researchers at Jefferson's Kimmel Cancer Center has shown in a study published online Feb. 6 in the Journal of Clinical Investigation that the oncogene cyclin D1 may promote a genetic breakdown known as chromosomal instability (CIN). CIN is a known, yet poorly understood culprit in tumor progression.

417

UCSD researchers find that tumor suppressor mutations alone don't explain deadly cancer  

Cancer.gov

Although mutations in a gene dubbed 'the guardian of the genome' are widely recognized as being associated with more aggressive forms of cancer, researchers have found evidence suggesting that the deleterious health effects of the mutated gene may in large part be due to other genetic abnormalities, at least in squamous cell head and neck cancers.

418

Self-Regulation Advantage for High-IQ Children: Findings from a Research Study  

ERIC Educational Resources Information Center

Current approaches in intelligence research indicate the need for a more extensive determination of characteristics of children with possible giftedness, not only at an intellectual level, but also at the level of self-regulation and motivation. The present study compares self-regulation efficiency between high-IQ and average-ability children aged…

Calero, Maria Dolores; Garcia-Martin, Maria Belen; Jimenez, Maria Isabel; Kazen, Miguel; Araque, Arsenio

2007-01-01

419

Moffitt research finds no survival advantage for stem cell versus bone marrow transplant  

Cancer.gov

Researchers at Moffitt Cancer Center, and colleagues in the Blood and Marrow Transplant Clinical Trials Network conducted a two-year clinical trial comparing two-year survival probabilities for patients transplanted with peripheral blood stem cells or bone marrow stem cells from unrelated donors and found no survival advantage for one method over the other.

420

University of Washington researchers find community effort brings lasting drop in smoking, delinquency, drug use:  

Cancer.gov

Tenth graders in towns using Communities That Care [a prevention system developed by University of Washington researchers] were less likely to have tried drinking or smoking compared with teens living in towns that had not adopted the system. Delinquent behavior, including stealing, vandalism and physical fights, decreased too.

421

Census of Institutional Repositories in the United States: MIRACLE Project Research Findings. CLIR Publication No. 140  

ERIC Educational Resources Information Center

In this report, the authors describe results of a nationwide census of institutional repositories in U.S. academic institutions. The census is one of several activities of the MIRACLE Project, an Institute of Museum and Library Services (IMLS)-funded research program based at the University of Michigan. The acronym MIRACLE means "Making…

Markey, Karen; Rieh, Soo Young; St. Jean, Beth; Kim, Jihyun; Yakel, Elizabeth

2007-01-01

422

Nanotoxicology and nanotechnology: new findings from the NIEHS and Superfund Research Program scientific community.  

PubMed

Nanomaterials are characterized by their small size (i.e., nanometer scale) and can be engineered from nearly any chemical substance, creating materials that differ in composition, particle size, shape, and surface coatings. These materials are often seen as a "double-edged sword" by having properties that make them potentially beneficial in product development, drug delivery, and remediation of hazardous substances, but these same properties may result in interaction with biological systems and potential effects in the environment. The National Institute of Environmental Health Sciences (NIEHS) is interested in both the potential risks associated with exposure to these materials, while harnessing the power of engineered nanomaterials to improve public health. This presentation will consist of discussion of nanoparticle studies by NIEHS researchers and the extramural community and its efforts to develop cross-agency initiatives to solve the many vexing issues associated with nanomaterials. For example, researchers from the NIEHS National Toxicology Program (NTP) are evaluating a number of nanomaterial classes in comprehensive toxicology studies. NIEHS also has an extensive extramural research grant portfolio consisting of the Nano Grand Opportunities (Nano GO) Program and NIEHS Centers for Nanotechnology Health Implications Research (NCNHIR) Consortium consisting of U19 and U01 Cooperative Centers. Furthermore, the NIEHS Superfund Research Program (SRP), which supports a network of university (P42, R01), small business (SBIR/STTR), and training grants (R25), provides funding to grantees evaluating the toxicology of nanomaterials, developing new or improved nanotechnologies to monitor and remediate hazardous substances, and training professionals in the use of these of materials. The NIEHS's Worker Education Branch also offers educational materials for training workers on risks of nanotechnology in laboratories, manufacturing facilities, at hazardous waste cleanup sites, and during emergency responses. In conclusion, this presentation will stimulate dialogue regarding the need for more research on these complex materials and serve as a resource about the wide variety of ongoing studies on nanomaterials at NIEHS that will contribute to the determination of risk associated with this class of compounds. PMID:24695034

Carlin, Danielle J

2014-01-01

423

Making life easier with effort: Basic findings and applied research on response effort  

PubMed Central

Early basic research showed that increases in required response effort (or force) produced effects that resembled those produced by punishment. A recent study by Alling and Poling determined some subtle differences between the two behavior-change strategies, but also confirmed that increasing required effort is an effective response-reduction procedure with enduring effects. In this paper we summarize basic research on response effort and explore the role of effort in diverse applied areas including deceleration of aberrant behavior, attention deficit hyperactivity disorder, oral habits, health care appointment keeping, littering, indexes of functional disability, and problem solving. We conclude that renewed interest in response effort as an independent variable is justified because of its potent effects and because the political constraints imposed on punishment- and reinforcement-based procedures have yet to be imposed on procedures that entail manipulations of response effort. PMID:16795886

Friman, Patrick C.; Poling, Alan

1995-01-01

424

New Study Finds Increasing Gender Equity at U.S. Research Institutions  

NASA Astrophysics Data System (ADS)

Women and men faculty in science, engineering, and mathematics for the most part have comparable opportunities within major U.S. research universities, according to a report released 2 June by the U.S. National Research Council (NRC). The report found that gender does not appear to have been a factor in a number of important career transitions and outcomes, including hiring for tenure track and tenure positions and promotions. “That is probably going to be surprising to many people. It was surprising to our own panel. And it may not have been the case if we had done the study in 1985 instead of 2005,” said Claude Canizares, cochair of the NRC committee that prepared the report, entitled Gender Differences at Critical Transitions in the Careers of Science, Engineering and Mathematics Faculty.

Showstack, Randy

2009-06-01

425

Improving mental health practices in primary care: findings from recent research.  

PubMed Central

This paper reviews restraints on the provision of mental health services in primary health care under the broad categories of physician profile, patient behavior, the nature of psychiatric illness as presented in primary care, and service system characteristics. An extensive research agenda is proposed toward improving mental health care in primary care settings. Research recommendations focus on the following types of issues: seeking a better understanding of the clinical decision making process when confronted with psychological or emotional problems, designing more focused mental health training for primary care physicians and nurses, providing patient education to encourage communication of psychosocial problems to medical providers, clarifying the nature and course of psychiatric disorder in primary care, designing innovative clinical interventions applicable to primary care, and examining organizational models for better coordination of health and mental health services. PMID:3923537

Burns, B J; Burke, J D

1985-01-01

426

Minorities and energy: a review of recent findings and a guide to future research  

SciTech Connect

This report discusses the results of the research on minority energy consumption and expenditures being conducted by Argonne National Laboratory for the US Department of Energy's Office of Minority Economic Impact. After summarizing what was known about minorities and energy prior to 1982, the paper briefly reviews current research results in the areas of minority residential and transportation energy use patterns, energy policy assessments, and minority energy business development. The results suggest that, when income and location (transportation) or climate (residential) are statistically controlled, black households differ from nonblack households in their ability or willingness to make long-term capital investments in energy-efficient consumer durables (e.g., automobiles and appliances). Two hypotheses to explain these results are proposed, relating to the culture of minority poverty and structural constraints. Implications of the current results and proposed hypotheses are then briefly discussed.

Throgmorton, J.A.; Bernard, M.J. III

1986-01-01

427

A lesson from Japan: research and development efficiency is a key element of pharmaceutical industry consolidation process.  

PubMed

Scholarly attention to pharmaceutical companies' ability to sustain research and development (R&D) productivity has increased as they increasingly handle business challenges. Furthermore, the deterioration of R&D productivity has long been considered a major cause of mergers and acquisitions (M&As). This study attempts to investigate quantitatively the possible causes of the deterioration and the relationship between the deterioration and M&As by examining the Japanese pharmaceutical industry. Japan from 1980 to 1997 is an ideal case because of the availability of official data, but more importantly the significant changes in its business environment at the time. Using the Malmquist Index and data envelopment analysis, we measured the deterioration of R&D productivity from 1980 to 1997 based on a sample of 15 Japanese companies. Two lessons can be learned from Japan's case. First, to sustain R&D productivity over the long term, companies should use licensing activities and focus on the dominant therapeutic franchises. Second, if a company fails significantly to catch up with the benchmark, it is likely to pursue an M&A or seek an alternative way to improve R&D productivity. These findings appear similar to the current situation of the global pharmaceutical industry, although Japan pursued more licensing activities than M&A to improve R&D productivity. PMID:24647159

Shimura, Hirohisa; Masuda, Sachiko; Kimura, Hiromichi

2014-02-01

428

UCBerkeleyNews: Cables Hold Promise in Protecting Existing Buildings from Bombs, Researchers Find  

NSDL National Science Digital Library

A civil engineering professor at the University of California at Berkeley is working on a novel way of maintaining a building's structural stability after an earthquake or terrorist bomb. The team of researchers working with the professor have designed and tested a system that uses cables for backup support in case main support beams failed. An overview of the system is provided in a February 20, 2003 news article.

Yang, Sarah.

2003-01-01

429

Depression secondary to anxiety: findings from the McLean Hospital Depression Research Facility  

Microsoft Academic Search

Methodologic issues pertinent to the study of depression secondary to anxiety are reviewed. Data on the frequency and temporal sequence of comorbid DSM-III-R anxiety and depressive disorders in a sample from the McLean Hospital Depression Research Facility are presented. Patients with major depression secondary to anxiety are compared with major depressed patients without anxiety on a variety of demographic and

Alan F. Schatzberg; Jacqueline A. Samson; Anthony J. Rothschild; Monica M. Luciana; R. F. Bruno; Thomas C. Bond

1990-01-01

430

The Impact of the Pill on Implantation Factors—New Research Findings  

Microsoft Academic Search

For health consumers and health care professionals of an orthodox Judeo-Christian or Islamic tradition, as w ell as those authentically concerned with the universal respect of unqualified human rights, the asserted capacity of the pill to act as an abortifacient, both in its once-a-day and 'mo rning-after' permutations, is one of significant moral weight. The research on 'break-through' ovulation 1

John Wilks; B. Pharm; MPS MACPP

431

Emory University researchers find new pathway for regulation of blood vessel growth in cancer  

Cancer.gov

Researchers at Winship Cancer Institute of Emory University have identified a new function for a gene that normally prevents the development of cancer. Scientists had known that the gene, which encodes a protein called p14 ARF, works inside the cell to control proliferation and division. The Winship team discovered that p14 ARF also regulates tumor-induced angiogenesis, the process by which growing cancers attract new blood vessels.

432

UC San Diego researchers find an enzyme that offers new therapeutic target for cancer drugs  

Cancer.gov

Researchers at the University of California, San Diego School of Medicine have uncovered a new signal transduction pathway specifically devoted to the regulation of alternative RNA splicing, a process that allows a single gene to produce or code multiple types of protein variants. The discovery, published in the June 27, 2012 issue of Molecular Cell, suggests the new pathway might be a fruitful target for new cancer drugs. The University of California, San Diego is home to the Moores Comprehensive Cancer Center.

433

Stanford University researchers find that dual-action protein better restricts blood vessel formation:  

Cancer.gov

In a paper published online Aug. 8 in the Proceedings of the National Academy of Sciences, researchers at Stanford University describe the creation of a new type of engineered protein that is significantly more effective at preventing the formation of blood vessels by targeting not one, but two of the chemical receptors that control the creation of new capillaries -- a process known as angiogenesis. The study shows that the new protein blocks both receptors.

434

Researchers Find that a Small Molecule Can Activate an Important Cancer Suppressor Gene  

Cancer.gov

By activating a cancer suppressor gene, a small molecule called nutlin-3a can block cancer cell division, according to researchers at the National Cancer Institute (NCI), part of the National Institutes of Health. This activation of the p53 gene leads to cellular senescence, a process by which cells lose their ability to grow and divide. An opportunity for new genetic mutations occurs each time a cell divides, so limiting the number of cell divisions in a cancer cell inhibits tumor progression.

435

Research for Key Techniques of Geophysical Recognition System of Hydrocarbon-induced Magnetic Anomalies Based on Hydrocarbon Seepage Theory  

NASA Astrophysics Data System (ADS)

Hydrocarbon seepage effects can cause magnetic alteration zones in near surface, and the magnetic anomalies induced by the alteration zones can thus be used to locate oil-gas potential regions. In order to reduce the inaccuracy and multi-resolution of the hydrocarbon anomalies recognized only by magnetic data, and to meet the requirement of integrated management and sythetic analysis of multi-source geoscientfic data, it is necessary to construct a recognition system that integrates the functions of data management, real-time processing, synthetic evaluation, and geologic mapping. In this paper research for the key techniques of the system is discussed. Image processing methods can be applied to potential field images so as to make it easier for visual interpretation and geological understanding. For gravity or magnetic images, the anomalies with identical frequency-domain characteristics but different spatial distribution will reflect differently in texture and relevant textural statistics. Texture is a description of structural arrangements and spatial variation of a dataset or an image, and has been applied in many research fields. Textural analysis is a procedure that extracts textural features by image processing methods and thus obtains a quantitative or qualitative description of texture. When the two kinds of anomalies have no distinct difference in amplitude or overlap in frequency spectrum, they may be distinguishable due to their texture, which can be considered as textural contrast. Therefore, for the recognition system we propose a new “magnetic spots” recognition method based on image processing techniques. The method can be divided into 3 major steps: firstly, separate local anomalies caused by shallow, relatively small sources from the total magnetic field, and then pre-process the local magnetic anomaly data by image processing methods such that magnetic anomalies can be expressed as points, lines and polygons with spatial correlation, which includes histogram-equalization based image display, object recognition and extraction; then, mine the spatial characteristics and correlations of the magnetic anomalies using textural statistics and analysis, and study the features of known anomalous objects (closures, hydrocarbon-bearing structures, igneous rocks, etc.) in the same research area; finally, classify the anomalies, cluster them according to their similarity, and predict hydrocarbon induced “magnetic spots” combined with geologic, drilling and rock core data. The system uses the ArcGIS as the secondary development platform, inherits the basic functions of the ArcGIS, and develops two main sepecial functional modules, the module for conventional potential-field data processing methods and the module for feature extraction and enhancement based on image processing and analysis techniques. The system can be applied to realize the geophysical detection and recognition of near-surface hydrocarbon seepage anomalies, provide technical support for locating oil-gas potential regions, and promote geophysical data processing and interpretation to advance more efficiently.

Zhang, L.; Hao, T.; Zhao, B.

2009-12-01

436

Regenerating the Academic Workforce: The Careers, Intentions and Motivations of Higher Degree Research Students in Australia. Findings of the National Research Student Survey (NRSS)  

ERIC Educational Resources Information Center

This report is the culmination of a project carried out for the Australian Government Department of Education, Employment and Workplace Relations (DEEWR) by the Australian Council for Educational Research (ACER) in collaboration with the Centre for the Study of Higher Education (CSHE). The main findings of this report are based on the outcomes…

Edwards, Daniel; Bexley, Emmaline; Richardson, Sarah

2010-01-01

437

The educational gradient in marital disruption: a meta-analysis of European research findings.  

PubMed

A large number of empirical studies have investigated the effects of women's education on union dissolution in Europe, but results have varied substantially. This paper seeks to assess the relationship between educational attainment and the incidence of marital disruption by systematizing the existing empirical evidence. A quantitative literature review (a meta-analysis) was conducted to investigate the temporal change in the relationship, net of inter-study differences. The results point to a weakening of the positive educational gradient in marital disruption over time and even to a reversal in the direction of this gradient in some countries. The findings also show that the change in the educational gradient can be linked to an increase in access to divorce. Finally, the results suggest that women's empowerment has played an important role in changing the educational gradient, while the liberalization of divorce laws has not. PMID:24279466

Matysiak, Anna; Styrc, Marta; Vignoli, Daniele

2014-01-01

438

Microdialysis in equine research: a review of clinical and experimental findings.  

PubMed

Microdialysis is a method for sampling compounds from extracellular fluid with minimal tissue trauma. Small hollow probes that are 0.2-0.5mm in diameter are inserted into the tissue and slowly perfused. The probe membrane is semi-permeable and a flux of the solutes occurs exclusively according to the concentration gradients. The recovered dialysate reflects changes in the composition of the extracellular water phase with a minor time delay. Because microdialysis is a continuous sampling method, it differs from point sample methods, such as blood sampling. The ability to obtain local measurements in the tissues has led to important discoveries in the detection of tissue changes within the areas of pharmacokinetics, pharmacodynamics, pathology and pathophysiology. New technological solutions, such as transportable pumps, fluid collectors and bedside analysers, have made microdialysis an indispensable tool for the surveillance of critically ill human patients, such as after brain injuries and reconstructive surgeries. The use of microdialysis in equine medicine has been sparingly described with only 14 published studies within muscle, pulmonary and hoof lamellar tissue, nasal mucosa, intestinal wall, uterine, allantoic and cerebrospinal fluid and blood. Only a few papers have been published within each area, indicating that few equine researchers are aware of the unique opportunities provided by the technique. This review discusses the theory and applications of microdialysis with a special emphasis on clinical and experimental equine studies, which may be useful to veterinary experimental and clinical researchers. PMID:23660155

Sørensen, M A; Jacobsen, S; Petersen, L J

2013-09-01

439

PLUME-FEATHER, Referencing and Finding Software for Research and Education  

NASA Astrophysics Data System (ADS)

PLUME-FEATHER is a non-profit project created to Promote economicaL, Useful and Maintained softwarE For the Higher Education And THE Research communities. The site references software, mainly Free/Libre Open Source Software (FLOSS) from French universities and national research organisations, (CNRS, INRA…), laboratories or departments as well as other FLOSS software used and evaluated by users within these institutions. Each software is represented by a reference card, which describes origin, aim, installation, cost (if applicable) and user experience from the point of view of an academic user for academic users. Presently over 1000 programs are referenced on PLUME. Although the server is maintained by a french institution, it is completely open to international contributions in the academic domainb. All contained and validated contents are visible to anonymous public, whereas registered users can contribute, starting with comments on single software reference cards up to help with the organisation and presentation of the referenced software products. This first presentation is call for (further) contributions from the HEP community.

Hoffmann, Dirk; Romier, Geneviève

2012-12-01

440

Disaster media coverage and psychological outcomes: descriptive findings in the extant research.  

PubMed

This review of the literature on disaster media coverage describes the events, samples, and forms of media coverage (television, newspapers, radio, internet) studied and examines the association between media consumption and psychological outcomes. A total of 36 studies representing both man-made and natural events met criteria for review in this analysis. Most studies examined disaster television viewing in the context of terrorism and explored a range of outcomes including posttraumatic stress disorder (PTSD) caseness and posttraumatic stress (PTS), depression, anxiety, stress reactions, and substance use. There is good evidence establishing a relationship between disaster television viewing and various psychological outcomes, especially PTSD caseness and PTS, but studies are too few to draw definitive conclusions about the other forms of media coverage that have been examined. As media technology continues to advance, future research is needed to investigate these additional media forms especially newer forms such as social media. PMID:25064691

Pfefferbaum, Betty; Newman, Elana; Nelson, Summer D; Nitiéma, Pascal; Pfefferbaum, Rose L; Rahman, Ambreen

2014-09-01

441

Measuring Masculinity in Research on Men of Color: Findings and Future Directions  

PubMed Central

The purpose of this study was to examine the association between masculinity and the health of US men of color aged 18 years and older. We identified 22 population-based studies that included a measure of masculinity and a measure of health behavior, mental health, or physical health. The associations between masculinity and health were complex and varied by construct and health outcome, though they generally were significant in the hypothesized directions. Future research should explore the centrality of masculinity versus other identities and characteristics, how the relationship between masculinity and health varies by health outcome, and the identification of the conceptions and aspects of masculinity that are most relevant to and associated with specific health behaviors and health outcomes. PMID:22401519

Gunter, Katie; Watkins, Daphne C.

2012-01-01

442

Measuring masculinity in research on men of color: findings and future directions.  

PubMed

The purpose of this study was to examine the association between masculinity and the health of US men of color aged 18 years and older. We identified 22 population-based studies that included a measure of masculinity and a measure of health behavior, mental health, or physical health. The associations between masculinity and health were complex and varied by construct and health outcome, though they generally were significant in the hypothesized directions. Future research should explore the centrality of masculinity versus other identities and characteristics, how the relationship between masculinity and health varies by health outcome, and the identification of the conceptions and aspects of masculinity that are most relevant to and associated with specific health behaviors and health outcomes. PMID:22401519

Griffith, Derek M; Gunter, Katie; Watkins, Daphne C

2012-05-01

443

Factors Predicting the Use of Technology: Findings From the Center for Research and Education on Aging and Technology Enhancement (CREATE)  

PubMed Central

The successful adoption of technology is becoming increasingly important to functional independence. The present article reports findings from the Center for Research and Education on Aging and Technology Enhancement (CREATE) on the use of technology among community-dwelling adults. The sample included 1,204 individuals ranging in age from 18–91 years. All participants completed a battery that included measures of demographic characteristics, self-rated health, experience with technology, attitudes toward computers, and component cognitive abilities. Findings indicate that the older adults were less likely than younger adults to use technology in general, computers, and the World Wide Web. The results also indicate that computer anxiety, fluid intelligence, and crystallized intelligence were important predictors of the use of technology. The relationship between age and adoption of technology was mediated by cognitive abilities, computer self-efficacy, and computer anxiety. These findings are discussed in terms of training strategies to promote technology adoption. PMID:16768579

Czaja, Sara J.; Charness, Neil; Fisk, Arthur D.; Hertzog, Christopher; Nair, Sankaran N.; Rogers, Wendy A.; Sharit, Joseph

2006-01-01

444

The ethics of sharing preliminary research findings during public health emergencies: a case study from the 2009 influenza pandemic.  

PubMed

During the 2009 A(H1N1) influenza pandemic, a suite of studies conducted in Canada showed an unexpected finding, that patients with medically attended laboratory-confirmed pandemic influenza were more likely to have received seasonal influenza vaccination than test-negative control patients. Different bodies, including scientific journals and government scientific advisory committees, reviewed the evidence simultaneously to determine its scientific validity and implications. Decision-making was complicated when the findings made their way into the media. The normal trajectory of non-urgent research includes peer-review publication after which decision-makers can process the information taking into account other evidence and logistic considerations. In the situation that arose, however, the congruence of an unexpected finding and the simultaneous review of the evidence both within and outside the traditional peer-review sphere raised several interesting issues about how to deal with emerging evidence during a public health emergency. These events are used in this article to aid discussion of the complex interrelationship between researchers, public health decision-makers and scientific journals, the trade-offs between sharing information early and maintaining the peer-review quality assurance process, and to emphasise the need for critical reflection on the practical and ethical norms that govern the way in which research is evaluated, published and communicated in public health emergencies. PMID:24970372

Crowcroft, N S; Rosella, L C; Pakes, B N

2014-01-01

445

"The role of oxytocin in psychiatric disorders: A review of biological and therapeutic research findings"  

PubMed Central

Oxytocin is a peptide hormone integral in parturition, milk let-down, and maternal behaviors that has been demonstrated in animal studies to be important in the formation of pair bonds and in social behaviors. This hormone is increasingly recognized as an important regulator of human social behaviors, including social decision making, evaluating and responding to social stimuli, mediating social interactions, and forming social memories. In addition, oxytocin is intricately involved in a broad array of neuropsychiatric functions, and may be a common factor important in multiple psychiatric disorders such as autism, schizophrenia, mood and anxiety disorders. This review article examines the extant literature on the evidence for oxytocin dysfunction in a variety of psychiatric disorders and highlights the need for further research to understand the complex role of the oxytocin system in psychiatric disease to pave the way for developing new therapeutic modalities. Articles were selected that involved human participants with various psychiatric disorders, either comparing oxytocin biology to healthy controls or examining the effects of exogenous oxytocin administration. PMID:24651556

Cochran, David; Fallon, Daniel; Hill, Michael; Frazier, Jean A.

2014-01-01

446

Rubber dam use during root canal treatment: findings from The Dental Practice-Based Research Network  

PubMed Central

Background The Dental Practice-Based Research Network (DPBRN) provides a venue to investigate whether certain procedures are performed routinely. Study objectives were to: (1) quantify rubber dam use during root canal treatment (RCT) among general dentists; (2) test the hypothesis that certain dentist or practice characteristics are associated with its use. Methods DPBRN practitioner-investigators participated in a questionnaire that included items about rubber dam use and other forms of isolation during root RCT. DPBRN Enrollment Questionnaire data provided certain practitioner and practice characteristics. Results A total of 729 practitioners responded (74%); 524 were general dentists and indicated they do RCT and the percentage of RCT in which they use a rubber dam. Of these 524, 44% use rubber dam for all RCTs; 24% use it for 51%–99% of RCTs; 17% use it for 1%–50%; 15% never use it during RCT. Usage varied significantly by geographic region and practice type. Cotton rolls and other forms of isolation were also reported. Conclusions Similar to other reports in the literature, not all DPBRN general dentists use a rubber dam during RCT. Clinical implications Because the current clinical standard of care is to use a rubber dam during RCT, increasing its use may be important. PMID:23372134

Anabtawi, Mona F.; Gilbert, Gregg H.; Bauer, Michael R.; Reams, Gregg; Makhija, Sonia K.; Benjamin, Paul L.; Williams, O. Dale

2012-01-01

447

Enhancing the Participation of African Americans in Health-Related Genetic Research: Findings of a Collaborative Academic and Community-Based Research Study  

PubMed Central

The involvement of African Americans in research has long been expressed as a concern by the scientific community. While efforts have been undertaken to identify factors inhibiting the participation of African Americans in health-related research, few efforts have been undertaken to have highlight factors associated with their engagement of health-related research. An exploratory study of factors presumed to be associated with participation in health-related research was conducted among a nonprobability sample of African Americans (n = 212) from a large urban community in the Midwest. The study was guided by a framework that hypothesized the influence of knowledge, beliefs, and perceptions about genetics and the involvement of providers in decision-making on willingness to participate in health-related genetic research. The results revealed that knowledge, beliefs, and perceptions about genetics and the involvement of providers were associated with willingness to engage in health-related genetic research (P < .05). The most interesting, however, was that 88.7% of the participants who had not previously been involved in a health-related study who expressed a willingness to participate reported that they “had never been asked.” Study findings suggest the need for research that further examines factors associated with the involvement of African Americans in health-related genetic research. PMID:24369499

Millon Underwood, Sandra; Buseh, Aaron G.; Kelber, Sheryl T.; Stevens, Patricia E.; Townsend, Leolia

2013-01-01

448

Key Findings of AAP Store Survey  

ERIC Educational Resources Information Center

Results of the Association of American Publishers "College Bookstore Marketing Survey" in the fall of 1976 are summarized. The intent was to improve college textbook publisher services to college stores in the areas of order fulfillment, publication scheduling, print quantities, shipping, billing, and processing of returns. (LBH)

Melendes, Bob; And Others

1977-01-01

449

NAWDEX: key to finding water data  

USGS Publications Warehouse

As our Nation's resources are developed, water will play an increasingly important role, both as a resource to be developed and as a resource to be protected. The proper development and protection of our water resources, however, will depend on adequate data on the quantity and quality of our water. Much data have already been collected by hundreds of agencies, and much more are continuously being collected. Even though a vast amount of data is being collected, the potential user faces a bewildering problem in trying to determine if the specific information he needs has been collected and where it is available. To help solve these problems of matching user needs to available data, NAWDEX the National Water Data Exchange has been established.

Edwards, Melvin D.

1978-01-01

450

Do Students Eventually Get to Publish their Research Findings? The Case of Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Research in Cameroon  

PubMed Central

Background: Scientific publication is commonly used to communicate research findings and in most academic/research settings, to evaluate the potential of a researcher and for recruitment and promotion. It has also been said that researchers have the duty to make public, the findings of their research. As a result, researchers are encouraged to share their research findings with the scientific world through peer review publications. In this study, we looked at the characteristics and publication rate of theses that documented studies on human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome in Cameroon. Materials and Methods: To check if a thesis resulted in a publication, we searched: A database of publications on HIV in Cameroon, African Journals Online, PubMed and Google scholar. For each publication we recorded if the student was an author, the position of the student in the author listing, the journal and where the journal was indexed. We also looked at the impact factor of the journals. Results: One hundred and thirty theses/dissertations were included in the study, 74.6% (97/130) were written as part of a medical degree (MD), 23.8% (31/130) a postgraduate (PG) degree and 1.5% (2/130) for a Doctorate/PhD. On a whole, 13.9% (18/130) of the theses resulted in at least one publication in a scientific journal with a total of 22 journal articles, giving a mean publication rate of 0.17 article/thesis, 86.4% (11/22) were indexed on PubMed, 9.1% (2/22) on African Journals Online and 4.6% (1/22) on Google scholar. One PG thesis led to two book chapters. The student was the first author in 22.7% (5/22) of the articles and not an author in 9.1% (2/22) of the articles. Student supervisor was an author in all the articles. Conclusion: This study reveals that most students in Cameroon failed to transform their theses/dissertations to scientific publications. This indicates an urgent need to sensitize students on the importance of presenting their research findings in scientific meetings and peer reviewed journals. There is also a great necessity to build capacity in scientific writing among university students in Cameroon. PMID:24971222

Munung, NS; Vidal, L; Ouwe-Missi-Oukem-Boyer, O

2014-01-01

451

Increasing Capacity for Stewardship of Oceans and Coasts: Findings of the National Research Council Report  

NASA Astrophysics Data System (ADS)

With the increasing stress on ocean and coastal resources, ocean resource management will require greater capacity in terms of people, institutions, technology and tools. Successful capacity-building efforts address the needs of a specific locale or region and include plans to maintain and expand capacity after the project ends. In 2008, the US National Research Council published a report that assesses past and current capacity-building efforts to identify barriers to effective management of coastal and marine resources. The report recommends ways that governments and organizations can strengthen marine conservation and management capacity. Capacity building programs instill the tools, knowledge, skills, and attitudes that address: ecosystem function and change; processes of governance that influence societal and ecosystem change; and assembling and managing interdisciplinary teams. Programs require efforts beyond traditional sector-by-sector planning because marine ecosystems range from the open ocean to coastal waters and land use practices. Collaboration among sectors, scaling from local community-based management to international ocean policies, and ranging from inland to offshore areas, will be required to establish coordinated and efficient governance of ocean and coastal ecosystems. Barriers Most capacity building activities have been initiated to address particular issues such as overfishing or coral reef degradation, or they target a particular region or country facing threats to their marine resources. This fragmentation inhibits the sharing of information and experience and makes it more difficult to design and implement management approaches at appropriate scales. Additional barriers that have limited the effectiveness of capacity building programs include: lack of an adequate needs assessment prior to program design and implementation; exclusion of targeted populations in decision- making efforts; mismanagement, corruption, or both; incomplete or inappropriate evaluation procedures; and, lack of a coordinated and strategic approach among donors. A New Framework Improving ocean stewardship and ending the fragmentation of current capacity building programs will require a new, broadly adopted framework for capacity building that emphasizes cooperation, sustainability, and knowledge transfer within and among communities. The report identifies four specific features of capacity building that would increase the effectiveness and efficiency of future programs: 1. Regional action plans based on periodic program assessments to guide investments in capacity and set realistic milestones and performance measures. 2. Long-term support to establish self-sustaining programs. Sustained capacity building programs require a diversity of sources and coordinated investments from local, regional, and international donors. 3. Development of leadership and political will. One of the most commonly cited reasons for failure and lack of progress in ocean and coastal governance initiatives is lack of political will. One strategy for strengthening support is to identify, develop, mentor, and reward leaders. 4. Establishment of networks and mechanisms for regional collaboration. Networks bring together those working in the same or similar ecosystems with comparable management or governance challenges to share information, pool resources, and learn from one another. The report also recommends the establishment of regional centers to encourage and support collaboration among neighboring countries.

Roberts, S. J.; Feeley, M. H.

2008-05-01

452

RESEARCH FINDINGS BASIC NEUROSCIENCES RESEARCH  

E-print Network

Receptor Subunits in the Ventral Tegmental Area Enhances Motivation for Cocaine Chronic cocaine use produces numerous biological changes in brain, but relatively few are functionally associated with cocaine reinforcement. Here the authors show that daily intravenous cocaine self-administration, but not passive cocaine

Bandettini, Peter A.

453

RESEARCH FINDINGS BASIC NEUROSCIENCE RESEARCH  

E-print Network

such as electrophysiology or neurochemistry, and they can be used to evaluate the effects of novel pharmacotherapies. One the effects of cocaine administration. The apparatus consists of a PVC cylindrical frame that encases to eliminate movement artifacts, which can distort the images. Another drawback for using anesthetized animals

Bandettini, Peter A.

454

The genetics of auricular development and malformation: new findings in model systems driving future directions for microtia research.  

PubMed

Microtia is a term used to describe a wide array of phenotypic presentations of the outer ear. Although the majority of the cases are isolated in nature, much of our understanding of the causes of microtia has been driven by the identification of genes underlying syndromic forms where the anomaly co-presents with various other craniofacial and extra-craniofacial structural defects. In this review we discuss recent findings in mice deficient in Hoxa2, a key regulator of branchial arch patterning, which has necessitated a revision to the canonical model of pinna morphogenesis. The revised model will likely impact current classification schemes for microtia and, as we argue in this review, the interpretation of the developmental basis for various auricular malformations. In addition, we highlight recent studies in other mammalian species that are providing the first clues as to possible causes of at least some isolated anomalies and thus should now accelerate the search for the more elusive genetic contributions to the many isolated and non-syndromic cases of microtia. These findings, together with the application of new genome-level sequencing technologies and more thorough quantitative assessment of available mutant mouse resources, promise an exciting future for genetic studies in microtia. PMID:24880027

Cox, Timothy C; Camci, Esra D; Vora, Siddharth; Luquetti, Daniela V; Turner, Eric E

2014-08-01

455

Managing misaligned paternity findings in research including sickle cell disease screening in Kenya: 'consulting communities' to inform policy.  

PubMed

The management of misaligned paternity findings raises important controversy worldwide. It has mainly, however, been discussed in the context of high-income countries. Genetic and genomics research, with the potential to show misaligned paternity, are becoming increasingly common in Africa. During a genomics study in Kenya, a dilemma arose over testing and sharing information on paternal sickle cell disease status. This dilemma may be paradigmatic of challenges in sharing misaligned paternity findings in many research and health care settings. Using a deliberative approach to community consultation to inform research practice, we explored residents' views on paternal testing and sharing misaligned paternity information. Between December 2009 and November 2010, 63 residents in Kilifi County were engaged in informed deliberative small group discussions, structured to support normative reflection within the groups, with purposive selection to explore diversity. Analysis was based on a modified framework analysis approach, drawing on relevant social science and bioethics literature. The methods generated in-depth individual and group reflection on morally important issues and uncovered wide diversity in views and values. Fundamental and conflicting values emerged around the importance of family interests and openness, underpinned by disagreement on the moral implications of marital infidelity and withholding truth. Wider consideration of ethical issues emerging in these debates supports locally-held reasoning that paternal sickle cell testing should not be undertaken in this context, in contrast to views that testing should be done with or without the disclosure of misaligned paternity information. The findings highlight the importance of facilitating wider testing of family members of affected children, contingent on the development and implementation of national policies for the management of this inherited disorder. Their richness also illustrates the potential for the approach adopted in this study to strengthen community consultation. PMID:24034967

Marsh, Vicki; Kombe, Francis; Fitzpatrick, Ray; Molyneux, Sassy; Parker, Michael

2013-11-01

456

Managing misaligned paternity findings in research including sickle cell disease screening in Kenya: 'Consulting communities' to inform policy?  

PubMed Central

The management of misaligned paternity findings raises important controversy worldwide. It has mainly, however, been discussed in the context of high-income countries. Genetic and genomics research, with the potential to show misaligned paternity, are becoming increasingly common in Africa. During a genomics study in Kenya, a dilemma arose over testing and sharing information on paternal sickle cell disease status. This dilemma may be paradigmatic of challenges in sharing misaligned paternity findings in many research and health care settings. Using a deliberative approach to community consultation to inform research practice, we explored residents' views on paternal testing and sharing misaligned paternity information. Between December 2009 and November 2010, 63 residents in Kilifi County were engaged in informed deliberative small group discussions, structured to support normative reflection within the groups, with purposive selection to explore diversity. Analysis was based on a modified framework analysis approach, drawing on relevant social science and bioethics literature. The methods generated in-depth individual and group reflection on morally important issues and uncovered wide diversity in views and values. Fundamental and conflicting values emerged around the importance of family interests and openness, underpinned by disagreement on the moral implications of marital infidelity and withholding truth. Wider consideration of ethical issues emerging in these debates supports locally-held reasoning that paternal sickle cell testing should not be undertaken in this context, in contrast to views that testing should be done with or without the disclosure of misaligned paternity information. The findings highlight the importance of facilitating wider testing of family members of affected children, contingent on the development and implementation of national policies for the management of this inherited disorder. Their richness also illustrates the potential for the approach adopted in this study to strengthen community consultation. PMID:24034967

Marsh, Vicki; Kombe, Francis; Fitzpatrick, Ray; Molyneux, Sassy; Parker, Michael

2013-01-01

457

Inheritance of resistance to facial eczema: a review of research findings from sheep and cattle in New Zealand.  

PubMed

Facial eczema (FE) is a costly problem to New Zealand pastoral agriculture, and has a detrimental impact on animal wellbeing. Incidence and severity of the disease can be reduced by grazing management and zinc prophylaxis. An additional strategy is to breed animals that are genetically resistant to intoxication with sporidesmin, the causative mycotoxin. This review summarises research findings on the inheritance of resistance of animals to FE, including evidence of among- and within-breed genetic variation, direct and correlated responses to selection, and identification of genetic markers and candidate genes for FE resistance. PMID:15768115

Morris, C A; Towers, N R; Hohenboken, W D; Maqbool, N; Smith, B L; Phua, S H

2004-10-01

458

St Jude researchers find that cancer diagnosis doesn’t increase a child’s risk of post-traumatic stress disorder  

Cancer.gov

St. Jude Children’s Research Hospital study suggests previous research overestimated PTSD in young cancer patients; new findings highlight the ability of children to adjust and even thrive in response to challenges.

459

Answer Keys  

NSDL National Science Digital Library

Answer keys provide acceptable answers to the questions posed in a case. Since these questions are intended to be answered by students and are often graded, keys are password-protected and access limited to registered instructors affiliated with an educational institution.

2010-01-01

460

Key Considerations for the Success of Medical Education Research and Innovation Units in Canada: Unit Director Perceptions  

ERIC Educational Resources Information Center

Growth in the field of medical education is evidenced by the proliferation of units dedicated to advancing Medical Education Research and Innovation (MERI). While a review of the literature discovered narrative accounts of MERI unit development, we found no systematic examinations of the dimensions of and structures that facilitate the success of…

Varpio, Lara; Bidlake, Erin; Humphrey-Murto, Sue; Sutherland, Stephanie; Hamstra, Stanley J.

2014-01-01

461

This is an incredible time to be a biologist. Every day, new research find-ings are presented, from the level of single molecules to whole ecosystems. A  

E-print Network

and contracts from foundations and government agencies, and with their students use state-of- the-art program. Five Research Areas 1. Biodiversity, Ecology and Conservation Biology This M.S. degree area, biogeography, behavioral ecology, plant ecology, ethnobotany, plant-animal interactions, and conservation

de Lijser, Peter

462

Key Facts  

Cancer.gov

Key Facts Scientists know that: I-131 breaks down rapidly in the atmosphere and environment Exposure was highest in the first few days after each nuclear test explosion Most exposure occurred through drinking fresh milk People received little exposure

463

H.U.B city steps: methods and early findings from a community-based participatory research trial to reduce blood pressure among african americans  

Microsoft Academic Search

Background  Community-based participatory research (CBPR) has been recognized as an important approach to develop and execute health interventions\\u000a among marginalized populations, and a key strategy to translate research into practice to help reduce health disparities.\\u000a Despite growing interest in the CBPR approach, CBPR initiatives rarely use experimental or other rigorous research designs\\u000a to evaluate health outcomes. This behavioral study describes the

Jamie M Zoellner; Carol C Connell; Michael B Madson; Bo Wang; Vickie Blakely Reed; Elaine Fontenot Molaison; Kathleen Yadrick

2011-01-01

464

Marketing Education National Research Conference Report. Marketing Practices: Implications for Developing a Future Workforce. (Key West, Florida, April 15-17, 1994).  

ERIC Educational Resources Information Center

This conference provided a forum for presenting research findings to educators and other audiences interested in marketing education. The following papers were presented: "Application and Utilization of the Marketing Education Baccalaureate Degree in the Public School--Training and Development Arenas" (Wyant, Prey); "The Impact of Alternative…

Norwood, Marcella M., Ed.

465

Quantum Key Distribution Protocol with Private-Public Key  

E-print Network

A quantum cryptographic protocol based in public key cryptography combinations and private key cryptography is presented. Unlike the BB84 protocol [1] and its many variants [2,3] two quantum channels are used. The present research does not make reconciliation mechanisms of information to derive the key. A three related system of key distribution are described.

Eduin H. Serna

2009-08-17

466

Reducing Adverse Childhood Experiences (ACE) by Building Community Capacity: A Summary of Washington Family Policy Council Research Findings  

PubMed Central

Community capacity for organization and collaboration has been shown to be a powerful tool for improving the health and well-being of communities. Since 1994 the Washington State Family Policy Council has supported the development of community capacity in 42 community public health and safety networks. Community networks bring local communities together to restructure natural supports and local resources to meet the needs of families and children, and increase cross-system coordination and flexible funding streams to improve local services and policy. In this study, researchers sought to demonstrate the strong impact of the community networks’ capacity to interrupt health and social problems. Findings suggest that community networks reduce health and safety problems for the entire community population. Further, community networks with high community capacity reduced adverse childhood experiences (ACE) in young adults ages 18–34. PMID:22970785

Hall, Judy; Porter, Laura; Longhi, Dario; Becker-Green, Jody; Dreyfus, Susan

2012-01-01

467

Proc. of the Fourteenth International Florida Artificial Intelligence Research Soc. Conf., Key West, FL, May 2001, pp. 211215 Using the Atlas Planning Engine to Drive an Intelligent Tutoring System  

E-print Network

Proc. of the Fourteenth International Florida Artificial Intelligence Research Soc. Conf., Key West. of the Fourteenth International Florida Artificial Intelligence Research Soc. Conf., Key West, FL, May 2001, pp. 211 to solve problems in cardiovascular physiology dealing with the regulation of blood pressure. Use

468

Proc. of the Fourteenth International Florida Artificial Intelligence Research Soc. Conf., Key West, FL, May 2001, pp. 211-215 Using the Atlas Planning Engine to Drive an Intelligent Tutoring System  

E-print Network

Proc. of the Fourteenth International Florida Artificial Intelligence Research Soc. Conf., Key West. of the Fourteenth International Florida Artificial Intelligence Research Soc. Conf., Key West, FL, May 2001, pp. 211 to solve problems in cardiovascular physiology dealing with the regulation of blood pressure. Use

469

Finding people who will tell you their thoughts on genomics-recruitment strategies for social sciences research.  

PubMed

This paper offers a description of how social media, traditional media and direct invitation were used as tools for the recruitment of 6,944 research participants for a social sciences study on genomics. The remit was to gather the views of various stakeholders towards sharing incidental findings from whole genome studies. This involved recruiting members of the public, genetic health professionals, genomic researchers and non-genetic health professionals. A novel survey was designed that contained ten integrated films; this was made available online and open for completion by anyone worldwide. The recruitment methods are described together with the convenience and snowballing sampling framework. The most successful strategy involved the utilisation of social media; Facebook, Blogging, Twitter, LinkedIn and Google Ads led to the ascertainment of over 75 % of the final sample. We conclude that the strategies used were successful in recruiting in eclectic mix of appropriate participants. Design of the survey and results from the study are presented separately. PMID:24535681

Middleton, A; Bragin, E; Parker, M

2014-10-01

470

Knowledge Generation: We generate new knowledge through academic research to find more effective ways of managing our society's human and environmental resources.  

E-print Network

Knowledge Generation: We generate new knowledge through academic research to find more effective our knowledge stagnates. Support for the creation and dissemination of academic research helps us of social marketing. Researchers attend from around the globe, sharing their knowledge and learning from

Morris, Joy

471

UUnlocking secrets of the vadose zone: Researchers say this layer of soil holds keys to tracking water’s every move  

E-print Network

Story by Leslie Lee 6 tx H2O Fall 2012 Unlocking secrets of the vadose zone Researchers say this layer of soil holds keys to tracking water?s every move Fall 2012 tx H2O 7 ] Sayena Farid-Marandi collects ground- based soil moisture data... problems. This story examines Dr. Binayak Mohanty and his team?s investigation into the vadose zone to help solve issues related to global water management, agriculture, flood forecasting, climate prediction, weather, energy balance and contaminant...

Lee, Leslie

2012-01-01

472

Key Nutrients.  

ERIC Educational Resources Information Center

Lessons written to help trainer agents prepare aides for work with families in the Food and Nutrition Program are presented in this booklet. The key nutrients discussed in the 10 lessons are protein, carbohydrates, fat, calcium, iron, iodine, and Vitamins A, B, C, and D. the format of each lesson is as follows: Purpose, Presentation, Application…

Federal Extension Service (USDA), Washington, DC.

473

Nine Key Functions 33 Journal of Empirical Research on Human Research Ethics, pp. 3347. print issn 1556-2646, online issn 1556-2654. 2010 by joan sieber.  

E-print Network

press's rights and permissions website, http://www.ucpressjournals.com/reprintinfo.asp. DOI: 10.1525/jer-risk ratio; (3) fair subject selection; (4) adequate monitoring; (5) in- formed consent; (6) privacy T henewunitedstatesnationalinstitutesof Health/National Center for Research Resources (NIH/NCRR) Clinical and Translational Science Award

474

If you cannot find what you are looking for quickly, please contact Research Liaison Officer Steve Penny Steve.penny@forestry.gsi.gov.uk 0780 890 0331  

E-print Network

­ Steve Penny Steve.penny@forestry.gsi.gov.uk 0780 890 0331 Key web links: Research Update 17th November, events, publications, newletters etc. can be found through the FR website: www.forestry pages. 2. Register for the FR newsletter: newsletter@forestry.gsi.gov.uk 3. Register for events

475

Using Abductive Research Logic: "The Logic of Discovery", to Construct a Rigorous Explanation of Amorphous Evaluation Findings  

ERIC Educational Resources Information Center

Background: Two kinds of research logic prevail in scientific research: deductive research logic and inductive research logic. However, both fail in the field of evaluation, especially evaluation conducted in unfamiliar environments. Purpose: In this article I wish to suggest the application of a research logic--"abduction"--"the logic of…

Levin-Rozalis, Miri

2010-01-01

476

Employee savvy is the key to fiscal success  

Microsoft Academic Search

Purpose – The purpose of this paper is to clarify employee financial prowess at every level as a key to good library management beyond the responsibilities of directors. Design\\/methodology\\/approach – The paper presents a general review. Findings – The paper finds that all employees of a library must possess and exemplify a general sense of fiscal savvy. Research limitations\\/implications –

Terry Cottrell

2010-01-01

477

The impact of the 1991 Gulf War on the mind and brain: findings from neuropsychological and neuroimaging research  

PubMed Central

Many veterans of the 1991 Gulf War (GW) have complained of somatic and cognitive symptoms that may be neurological in nature. However, whether or not changes in brain function are associated with GW service continues to be debated. Studies of GW veterans using objective, performance-based neuropsychological measures have yielded inconsistent findings, with those indicating deficits among GW veterans typically revealing only relatively mild levels of neuropsychological impairment. Further, performances on objective neuropsychological tasks show little correspondence to subjective perceptions of cognitive functioning. Although preliminary magnetic resonance spectroscopy (MRS) studies demonstrate reduced N-acetylaspartate-to-creatine (NAA/Cr) ratio in select brain regions among GW veterans who report health concerns, this work requires further replication with larger, more representative samples. There is no evidence from neuroimaging studies of a non-specific effect of GW service or of changes in brain structure or function related to health status when conventional radiological methods are used. Owing to the paucity of objective exposure, baseline health data, and the now significant time elapsed since the GW, aetiological issues may never be fully resolved. Therefore, research addressing clinical management of GW veterans with neuropsychological dysfunction and neuroimaging abnormalities may prove more fruitful than exclusive focus on aetiology. PMID:16687264

Vasterling, Jennifer J; Bremner, J. Douglas

2006-01-01

478

Research.  

ERIC Educational Resources Information Center

This potpourri surveys research on various topics: neurologically based curricula, midafternoon slumps in student attention, accounting for contexts in research, feelings of powerlessness among students and teachers, further equity implications of computers in schools, misreporting of research findings, and accounting for media transfer in…

Bracey, Gerald W.

1984-01-01

479

PHYSICSATBERKELEY Measure for MeasureBerkeley atomic physics group finds the symmetry in basic and applied research  

E-print Network

interactions among the fundamen- tal particles that make up all matter. In particular, neutron EDM research can is subject to ever more rigorous experimental tests by several other research groups." Matter vs. Antimatter and applied research T he difference between basic and applied research can all too easily get boiled down

Pines, Alexander

480

H.U.B city steps: methods and early findings from a community-based participatory research trial to reduce blood pressure among african americans  

PubMed Central

Background Community-based participatory research (CBPR) has been recognized as an important approach to develop and execute health interventions among marginalized populations, and a key strategy to translate research into practice to help reduce health disparities. Despite growing interest in the CBPR approach, CBPR initiatives rarely use experimental or other rigorous research designs to evaluate health outcomes. This behavioral study describes the conceptual frameworks, methods, and early findings related to the reach, adoption, implementation, and effectiveness on primary blood pressure outcomes. Methods The CBPR, social support, and motivational interviewing frameworks are applied to test treatment effects of a two-phased CBPR walking intervention, including a 6-month active intervention quasi experimental phase and 12-month maintenance randomized controlled trial phase to test dose effects of motivational interviewing. A community advisory board helped develop and execute the culturally-appropriate intervention components which included social support walking groups led by peer coaches, pedometer diary self-monitoring, monthly diet and physical activity education sessions, and individualized motivational interviewing sessions. Although the study is on-going, three month data is available and reported. Analyses include descriptive statistics and paired t tests. Results Of 269 enrolled participants, most were African American (94%) females (85%) with a mean age of 43.8 (SD = 12.1) years. Across the 3 months, 90% of all possible pedometer diaries were submitted. Attendance at the monthly education sessions was approximately 33%. At the 3-month follow-up 227 (84%) participants were retained. From baseline to 3-months, systolic BP [126.0 (SD = 19.1) to 120.3 (SD = 17.9) mmHg; p < 0.001] and diastolic BP [83. 2 (SD = 12.3) to 80.2 (SD = 11.6) mmHg; p < 0.001] were significantly reduced. Conclusions This CBPR study highlights implementation factors and signifies the community's active participation in the development and execution of this study. Reach and representativeness of enrolled participants are discussed. Adherence to pedometer diary self-monitoring was better than education session participation. Significant decreases in the primary blood pressure outcomes demonstrate early effectiveness. Importantly, future analyses will evaluate long-term effectiveness of this CBPR behavioral intervention on health outcomes, and help inform the translational capabilities of CBPR efforts. PMID:21663652

2011-01-01

481

University Performance Data for Diversity in 2009-2010, CSU Research Findings for Student Success, Student Perceptions, and University Planning Activity  

E-print Network

for the Student Affairs in Higher Education Graduate Program. Kim Bender is the Director of Assessment (Office-appointment as the Executive Director of Research and Assessment for the Division of Student Affairs, and the Program ChairUniversity Performance Data for Diversity in 2009-2010, CSU Research Findings for Student Success

Boone, Randall B.

482

What can Studies of e-Learning Teach us about Collaboration in e-Research? Some Findings from Digital Library Studies  

Microsoft Academic Search

Abstract. e-Research is intended,to facilitate collaboration,through,distributed access to content, tools, and services. Lessons about collaboration are extracted from the findings of two large, long-term digital library research projects. Both the Alexandria Digital Earth Prototype Project (ADEPT) and,the Center for Embedded,Networked,Sensing (CENS) project on data management,leverage scientific research data for use in teaching. Two forms of collaboration were studied: (1) direct,

Christine L. Borgman

2006-01-01

483

Quantitative versus qualitative approaches: a comparison of two research methods applied to identification of key health issues for working horses in Lesotho.  

PubMed

The relative merits and potential complementarity of participatory methods and classical epidemiological techniques in veterinary-related research is a current topic of discussion. Few reported studies have applied both methodologies within the same research framework to enable direct comparison. The aim of this study was to compare issues identified by a classical epidemiological study of horses and their owners with those identified by owner communities using participatory approaches. In 2009, a cross-sectional survey was undertaken as part of an impact assessment study of farrier and saddler training programmes, and a small-scale nutrition trial, implemented in Lesotho by a UK-based equine charity. In total, 245 horses and their 237 owners participated in the survey which comprised a face-to-face structured questionnaire covering knowledge and practices relating to equine husbandry and primary healthcare, clinical examination and sampling of horses, and examination of tack used on those horses. In early 2010, 56 owners in three survey regions, some of whom participated in the survey, attended a participatory workshop. Each workshop group created a local resource map whilst discussing and identifying key issues associated with horse ownership and what might have an adverse impact on horse health and work. Following map completion, each group began by prioritising the identified issues, and then ranked them using a pairwise/ranking matrix to reflect how important issues were in relation to each other. Overall priority issues were: mouth problems, hunger and nutrition, diseases (including infectious diseases, parasites and colic), husbandry (including wound management), and feet and limb problems. Major health issues identified by cross-sectional study included sharp enamel points on teeth, endo- and ectoparasite infestation, suboptimal nutrition, tack-associated wounds, overgrown and poorly balanced feet and poor owner husbandry knowledge and practices. Whilst common issues were identified through the two research approaches, key differences also emerged. The classical, more quantitative approach provided objective measurement of problem frequency, which was compared with owners' perceptions of importance. The qualitative participatory approach provided greater opportunity for researchers to gain detailed understanding of local issues and appreciate how owners defined and prioritised problems affecting them and their animals. Both approaches provided valuable and complementary information that can be used to inform interventions aimed at providing sustainable improvements in the health and wellbeing of working animals and their owners. It is recommended that both quantitative and qualitative approaches are employed as part of detailed needs assessment work prior to defining and prioritising the charity's future interventions. PMID:23419786

Upjohn, M M; Attwood, G A; Lerotholi, T; Pfeiffer, D U; Verheyen, K L P

2013-03-01

484

Research Findings on a Virtual Training Center--Measuring Web Based Training as an Effective Project Management Facilitation Intervention.  

ERIC Educational Resources Information Center

This paper focuses on the design of an assessment plan that can accurately measure the impact of using World Wide Web-based deliveries to increase performance. Key trends in technology and training are reviewed, and effective assessment of online training deliveries is examined. The Virtual Business Training Center (VBTC) is an integrated business…

Hoyt, Brian; Stockman, Mark

485

They Can't Always Find What They Want; Kids' Online Behaviors Have Researchers Scratching Their Heads  

ERIC Educational Resources Information Center

Understanding precisely how young people search for online information is both easy and frustrating. It's a snap because we can easily observe kids sitting down at a computer, going straight to Google, typing in one or two key words, and selecting a few Web pages from a huge list of hits. It's frustrating because of the many questions their…

Minkel, Walter

2004-01-01

486

UK Full-Scale Non-Active vitrification development and implementation of research findings onto the waste vitrification plant  

SciTech Connect

This paper describes the historic and current status of inactive research in support of UK Highly Active (HA) waste vitrification. Experimental work performed to date on the UK's inactive vitrification research facility is summarised along with estimates of the potential impact of this research work on the reduction of HA Liquor (HAL) stocks stored in the UK at Sellafield. The current position regarding implementation of research learning onto the UK's operational vitrification plants is described. (authors)

Bradshaw, K.; Gribble, N.R. [Nexia Solutions, Sellafield, Seascale, CA (United Kingdom); Hughes, D.O.; Riley, A.D. [British Nuclear Group, Sellafield, Seascale, CA (United Kingdom)

2007-07-01

487

Using quantitative and qualitative data in health services research - what happens when mixed method findings conflict? [ISRCTN61522618  

PubMed Central

Background In this methodological paper we document the interpretation of a mixed methods study and outline an approach to dealing with apparent discrepancies between qualitative and quantitative research data in a pilot study evaluating whether welfare rights advice has an impact on health and social outcomes among a population aged 60 and over. Methods Quantitative and qualitative data were collected contemporaneously. Quantitative data were collected from 126 men and women aged over 60 within a randomised controlled trial. Participants received a full welfare benefits assessment which successfully identified additional financial and non-financial resources for 60% of them. A range of demographic, health and social outcome measures were assessed at baseline, 6, 12 and 24 month follow up. Qualitative data were collected from a sub-sample of 25 participants purposively selected to take part in individual interviews to examine the perceived impact of welfare rights advice. Results Separate analysis of the quantitative and qualitative data revealed discrepant findings. The quantitative data showed little evidence of significant differences of a size that would be of practical or clinical interest, suggesting that the intervention had no impact on these outcome measures. The qualitative data suggested wide-ranging impacts, indicating that the intervention had a positive effect. Six ways of further exploring these data were considered: (i) treating the methods as fundamentally different; (ii) exploring the methodological rigour of each component; (iii) exploring dataset comparability; (iv) collecting further data and making further comparisons; (v) exploring the process of the intervention; and (vi) exploring whether the outcomes of the two components match. Conclusion The study demonstrates how using mixed methods can lead to different and sometimes conflicting accounts and, using this six step approach, how such discrepancies can be harnessed to interrogate each dataset more fully. Not only does this enhance the robustness of the study, it may lead to different conclusions from those that would have been drawn through relying on one method alone and demonstrates the value of collecting both types of data within a single study. More widespread use of mixed methods in trials of complex interventions is likely to enhance the overall quality of the evidence base. PMID:16524479

Moffatt, Suzanne; White, Martin; Mackintosh, Joan; Howel, Denise

2006-01-01

488

Ambient Particulate Matter during MILAGRO in Mexico City: Main Findings, Impacts (on AQ and Climate), and Future Research Needs  

NASA Astrophysics Data System (ADS)

The MILAGRO campaign was a large international field experiments conduced in Mexico City and Central Mexico during March 2006. We present an overview of the main findings related to particulate matter and aerosol radiative properties. PM levels inside Mexico City were similar or higher than those in the most polluted North American cities, but ~5 times lower than levels in the most polluted Asian megacities During the study, PM10 and PM2.5 concentrations in the urban area of were about double the concentrations in the rural areas surrounding Mexico City. PM2.5 made up about half of the PM10 concentrations, with small amounts of mass in the PM2.5-PM1.0 range. Mineral matter made up approximately 25% of the PM10 and on average 15% and 28% of the PM2.5 in the urban and rural areas, respectively.