Science.gov

Sample records for key research findings

  1. Research on Self-Determination in Physical Education: Key Findings and Proposals for Future Research

    ERIC Educational Resources Information Center

    Van den Berghe, Lynn; Vansteenkiste, Maarten; Cardon, Greet; Kirk, David; Haerens, Leen

    2014-01-01

    Background: During the last 30 years, several theories of motivation have generated insights into the motives underlying learners' behavior in physical education. Self-determination theory (SDT), a general theory on social development and motivation, has enjoyed increasing popularity in physical education research during the past decade. SDT…

  2. Key Events and Lessons for Managers in a Diverse Workforce: A Report on Research and Findings.

    ERIC Educational Resources Information Center

    Douglas, Christina A.

    The research documented in this report builds on earlier work in the 1980s in the area of on-the-job experiences in developing effective leaders. The current study was designed to answer the following: (1) What are the significant events from which African American managers learn and develop? (2) Are the key events and lessons learned different…

  3. Myalgic encephalomyelitis: a review with emphasis on key findings in biomedical research

    PubMed Central

    Hooper, M

    2007-01-01

    This review examines research findings in patients with myalgic encephalomyelitis in light of the current debate about this chronic multiple‐symptom, multiorgan, multisystem illness and the conflicting views in medicine. These issues cannot be separated from the political opinions and assertions that conflict with science and medicine, and will be part of this review as they have enormous consequences for scientific and medical research, patients, clinicians, carers and policy makers. PMID:16935967

  4. Research in Online and Blended Learning in the Business Disciplines: Key Findings and Possible Future Directions

    ERIC Educational Resources Information Center

    Arbaugh, J. B.; Godfrey, Michael R.; Johnson, Marianne; Pollack, Birgit Leisen; Niendorf, Bruce; Wresch, William

    2009-01-01

    In this literature review, we examine and assess the state of research of online and blended learning in the business disciplines with the intent of assessing the state of the field and identifying opportunities for meaningful future research. We review research from business disciplines such as Accounting, Economics, Finance, Information Systems…

  5. A decade of research using the CASP scale: key findings and future directions.

    PubMed

    Hyde, M; Higgs, P; Wiggins, R D; Blane, D

    2015-07-01

    Since the publication of A Measure of Quality of Life in Early Old Age: The Theory, Development and Properties of a Needs Satisfaction Model (CASP-19) just over 10 years ago, the scale has gone on to be used in a wide variety of studies in over 20 countries across the world and the original paper has become the most highly cited paper for Aging and Mental Health. Therefore it was felt that it was a good time to look back and reflect on the developments in the use of the scale as well as to look forward to what new research is being done and could be done with the measure. To this end we are extremely grateful for the editors for allowing us to bring together a collection of papers that represent cutting edge research using the CASP scale. These papers cover a wide variety of issues, from working conditions to religiosity, from a range of countries, covering Western and Eastern Europe as well as Africa. Each makes an important individual contribution to our understanding of the factors that influence quality of life in later life as well as pointing to the limitations of the measure and future work that can be done in this area. PMID:25847497

  6. Key Findings and Recommendations from the Coös Youth Study: Research from the First Half of the Study. Regional Issue Brief Number 41

    ERIC Educational Resources Information Center

    Staunton, Michael S.; Jaffee, Eleanor M.

    2014-01-01

    In this brief, authors Michael Staunton and Eleanor Jaffee review the key findings and recommendations from research conducted in the first half of the Coös Youth Study, which began in 2008 and is planned to continue through 2018. The study explores young people's decisions about their educational and job opportunities in rural northern New…

  7. Knowledge, ignorance and priorities for research in key areas of cancer survivorship: findings from a scoping review

    PubMed Central

    Richardson, A; Addington-Hall, J; Amir, Z; Foster, C; Stark, D; Armes, J; Brearley, S G; Hodges, L; Hook, J; Jarrett, N; Stamataki, Z; Scott, I; Walker, J; Ziegler, L; Sharpe, M

    2011-01-01

    research funding environment, we suggest areas in which strategic investment might give findings that have the potential to make a major impact on patient well-being in a 5-year time scale. PMID:22048036

  8. The Relationship of Family Support to Family Outcomes: A Synthesis of Key Findings from Research on Severe Disability

    ERIC Educational Resources Information Center

    Kyzar, Kathleen B.; Turnbull, Ann P.; Summers, Jean Ann; Gomez, Viviana Aya

    2012-01-01

    There has been a gradual shift from a deficit to a support model for understanding disability over the last two decades. Although more attention is focused on supports at the individual level, policy has provided for the provision of family support. Despite this policy, families' needs for support are on the rise; and research suggests that…

  9. Nanofluids Research: Key Issues

    PubMed Central

    2010-01-01

    Nanofluids are a new class of fluids engineered by dispersing nanometer-size structures (particles, fibers, tubes, droplets) in base fluids. The very essence of nanofluids research and development is to enhance fluid macroscopic and megascale properties such as thermal conductivity through manipulating microscopic physics (structures, properties and activities). Therefore, the success of nanofluid technology depends very much on how well we can address issues like effective means of microscale manipulation, interplays among physics at different scales and optimization of microscale physics for the optimal megascale properties. In this work, we take heat-conduction nanofluids as examples to review methodologies available to effectively tackle these key but difficult problems and identify the future research needs as well. The reviewed techniques include nanofluids synthesis through liquid-phase chemical reactions in continuous-flow microfluidic microreactors, scaling-up by the volume averaging and constructal design with the constructal theory. The identified areas of future research contain microfluidic nanofluids, thermal waves and constructal nanofluids. PMID:20676214

  10. Framing and global health governance: key findings.

    PubMed

    McInnes, Colin; Lee, Kelley

    2012-01-01

    Despite widespread agreement that collective action to address shared health challenges across countries is desirable and necessary, the realm of global health governance has remained highly problematic. A key reason for this is the manner in which health issues are presented ('framed'). Because multiple frames are operating simultaneously, confusion and a range of competing policy recommendations and priorities result. Drawing on the previous articles published in this Special Supplement, these key findings explore how health issues are framed, what makes a framing successful, what frames are used for and what effects framing has. PMID:23088193

  11. Developing International Research Collaborations among Postdoctoral Fellows: Key Findings from the Evaluation of NSF's International Research Fellowship Program. GS-10F-0086K

    ERIC Educational Resources Information Center

    Martinez, Alina; Epstein, Carter; Parsad, Amanda; Whittaker, Karla

    2012-01-01

    Over a decade ago, the National Science Board (NSB) highlighted the importance of international collaboration in its call for increased government commitment to promoting international science and engineering (S&E) research and education. The NSB also identified the National Science Foundation (NSF) as having an important leadership role in…

  12. Institutional Data Management in Higher Education. ECAR Key Findings

    ERIC Educational Resources Information Center

    Yanosky, Ronald

    2009-01-01

    This document presents the key findings from the 2009 ECAR (EDUCAUSE Center for Applied Research) study of institutional data management, which examines the policies and practices by which higher education institutions effectively collect, protect, and use digital information assets to meet academic and business needs. Importantly, it also…

  13. Perceptual Tests of an Algorithm for Musical Key-Finding

    ERIC Educational Resources Information Center

    Schmuckler, Mark A.; Tomovski, Robert

    2005-01-01

    Perceiving the tonality of a musical passage is a fundamental aspect of the experience of hearing music. Models for determining tonality have thus occupied a central place in music cognition research. Three experiments investigated 1 well-known model of tonal determination: the Krumhansl-Schmuckler key-finding algorithm. In Experiment 1,…

  14. Powering Down: Green IT in Higher Education. Key Findings

    ERIC Educational Resources Information Center

    Sheehan, Mark C.

    2010-01-01

    This document presents the key findings from "Powering Down: Green IT in Higher Education," the 2010 ECAR (EDUCAUSE Center for Applied Research) study of green IT. The study examines the stance institutions and their central IT organizations are taking on environmental sustainability (ES), the progress they are making on a variety of key…

  15. Key findings of the national weatherization evaluation

    SciTech Connect

    Brown, M.A.; Berry, L.G.

    1994-10-01

    In 1990, the U.S. Department of Energy sponsored a comprehensive evaluation of its Weatherization Assistance Program, the nation`s largest residential energy conservation program. The primary goal of the evaluation was to establish whether the Program meets the objectives of its enabling legislation and fulfills its mission statement, to reduce the heating and cooling costs for low-income families-particularly the elderly, persons with disabilities, and children by improving the energy-efficiency of their homes and ensuring their health and safety. Oak Ridge National Laboratory managed a five-part study which produced a series of documents evaluating the Program. The objective of this document is to summarize the findings of the five-part National Weatherization Evaluation. The five studies were as follows: (1) Network Study-this study characterized the weatherization network`s leveraging, capabilities, procedures, staff, technologies, and innovations; (2) Resources and Population Study-this study profiled low-income weatherization resources, the weatherized population, and the population remaining to be served; (3) Multifamily Study-this study described the nature and extent of weatherization activities in larger multifamily buildings; (4) Single-family Study-this study estimated the national savings and cost- effectiveness of weatherizing single-family and small multifamily dwellings that use natural gas or electricity for space heating; (5) Fuel-Oil Study-this study estimated the savings and cost-effectiveness of weatherizing single-family homes, located in nine northeastern states, that use fuel oil for space heating. This paper provides a brief overview of each study`s purposes, research methods and most important findings.

  16. Knowledge translation of research findings

    PubMed Central

    2012-01-01

    Background One of the most consistent findings from clinical and health services research is the failure to translate research into practice and policy. As a result of these evidence-practice and policy gaps, patients fail to benefit optimally from advances in healthcare and are exposed to unnecessary risks of iatrogenic harms, and healthcare systems are exposed to unnecessary expenditure resulting in significant opportunity costs. Over the last decade, there has been increasing international policy and research attention on how to reduce the evidence-practice and policy gap. In this paper, we summarise the current concepts and evidence to guide knowledge translation activities, defined as T2 research (the translation of new clinical knowledge into improved health). We structure the article around five key questions: what should be transferred; to whom should research knowledge be transferred; by whom should research knowledge be transferred; how should research knowledge be transferred; and, with what effect should research knowledge be transferred? Discussion We suggest that the basic unit of knowledge translation should usually be up-to-date systematic reviews or other syntheses of research findings. Knowledge translators need to identify the key messages for different target audiences and to fashion these in language and knowledge translation products that are easily assimilated by different audiences. The relative importance of knowledge translation to different target audiences will vary by the type of research and appropriate endpoints of knowledge translation may vary across different stakeholder groups. There are a large number of planned knowledge translation models, derived from different disciplinary, contextual (i.e., setting), and target audience viewpoints. Most of these suggest that planned knowledge translation for healthcare professionals and consumers is more likely to be successful if the choice of knowledge translation strategy is informed by

  17. The NICHD Research Program in Reading Development, Reading Disorders and Reading Instruction: A Summary of Research Findings. Keys to Successful Learning: A National Summit on Research in Learning Disabilities.

    ERIC Educational Resources Information Center

    Lyon, Reid G.

    This monograph is a synthesis of research findings of the National Institute of Child Health and Human Development research program concerning how children learn to read, why some children and adults have difficulties learning to read, and effective ways to help children learn to read. The review covered studies performed over the last 33 years at…

  18. Public key infrastructure for DOE security research

    SciTech Connect

    Aiken, R.; Foster, I.; Johnston, W.E.

    1997-06-01

    This document summarizes the Department of Energy`s Second Joint Energy Research/Defence Programs Security Research Workshop. The workshop, built on the results of the first Joint Workshop which reviewed security requirements represented in a range of mission-critical ER and DP applications, discussed commonalties and differences in ER/DP requirements and approaches, and identified an integrated common set of security research priorities. One significant conclusion of the first workshop was that progress in a broad spectrum of DOE-relevant security problems and applications could best be addressed through public-key cryptography based systems, and therefore depended upon the existence of a robust, broadly deployed public-key infrastructure. Hence, public-key infrastructure ({open_quotes}PKI{close_quotes}) was adopted as a primary focus for the second workshop. The Second Joint Workshop covered a range of DOE security research and deployment efforts, as well as summaries of the state of the art in various areas relating to public-key technologies. Key findings were that a broad range of DOE applications can benefit from security architectures and technologies built on a robust, flexible, widely deployed public-key infrastructure; that there exists a collection of specific requirements for missing or undeveloped PKI functionality, together with a preliminary assessment of how these requirements can be met; that, while commercial developments can be expected to provide many relevant security technologies, there are important capabilities that commercial developments will not address, due to the unique scale, performance, diversity, distributed nature, and sensitivity of DOE applications; that DOE should encourage and support research activities intended to increase understanding of security technology requirements, and to develop critical components not forthcoming from other sources in a timely manner.

  19. Teacher Retirement Systems: Research Findings. Research Brief

    ERIC Educational Resources Information Center

    Hansen, Janet S.; Podgursky, Michael J.; Costrell, Robert M.

    2009-01-01

    This policy brief summarizes findings presented at a February 2009 research conference on teacher retirement systems hosted by the National Center on Performance Incentives (NCPI) at Vanderbilt University's Peabody College. The 2009 conference was the second in a series of NCPI events focusing on findings from recent research on issues related to…

  20. Finding a Voice through Research

    ERIC Educational Resources Information Center

    Lobo, Jose; Vizcaino, Alida

    2006-01-01

    One question guided this experimental study: What impact does the change from teacher training to educational research have on university teachers' methodology and attitudes to teaching? To find answers to this question, the researchers selected five teachers of English as a Foreign Language (EFL) at the language centre of a private university on…

  1. Effective radiology dashboards: key research findings.

    PubMed

    Karami, Mahtab; Safdari, Reza; Rahimi, Azin

    2013-01-01

    Innovative organizations have access to information for business intelligence through the objectives displayed in dashboards. In healthcare organizations, where the goal is to improve quality of care along with reducing costs, the radiology department is important from both financial and clinical aspects. Therefore, how to manage this department has critical impact on the effectiveness and efficiency of the organization. Today, since the information in this department not only has different data structure but also is gathered from different data sources, a well defined, comprehensive dashboard can be an effective tool to enhance performance. PMID:23638580

  2. Functional Imaging of Autonomic Regulation: Methods and Key Findings

    PubMed Central

    Macey, Paul M.; Ogren, Jennifer A.; Kumar, Rajesh; Harper, Ronald M.

    2016-01-01

    Central nervous system processing of autonomic function involves a network of regions throughout the brain which can be visualized and measured with neuroimaging techniques, notably functional magnetic resonance imaging (fMRI). The development of fMRI procedures has both confirmed and extended earlier findings from animal models, and human stroke and lesion studies. Assessments with fMRI can elucidate interactions between different central sites in regulating normal autonomic patterning, and demonstrate how disturbed systems can interact to produce aberrant regulation during autonomic challenges. Understanding autonomic dysfunction in various illnesses reveals mechanisms that potentially lead to interventions in the impairments. The objectives here are to: (1) describe the fMRI neuroimaging methodology for assessment of autonomic neural control, (2) outline the widespread, lateralized distribution of function in autonomic sites in the normal brain which includes structures from the neocortex through the medulla and cerebellum, (3) illustrate the importance of the time course of neural changes when coordinating responses, and how those patterns are impacted in conditions of sleep-disordered breathing, and (4) highlight opportunities for future research studies with emerging methodologies. Methodological considerations specific to autonomic testing include timing of challenges relative to the underlying fMRI signal, spatial resolution sufficient to identify autonomic brainstem nuclei, blood pressure, and blood oxygenation influences on the fMRI signal, and the sustained timing, often measured in minutes of challenge periods and recovery. Key findings include the lateralized nature of autonomic organization, which is reminiscent of asymmetric motor, sensory, and language pathways. Testing brain function during autonomic challenges demonstrate closely-integrated timing of responses in connected brain areas during autonomic challenges, and the involvement with brain

  3. Food irradiation: Key research needs

    SciTech Connect

    Morehouse, K.M. )

    1993-01-01

    Treatment of foods with ionizing radiation reduces microbial infection and insect infestations, inhibits sprouting, and delays maturation, thereby extending the shelf life of foods. The treatment of different types of foods with ionizing radiation for specific purposes is accepted in several countries, although it is prohibited in others. The US Food and Drug Administration has established regulations to allow the treatment of several different foods with ionizing radiation and has received petitions for the approval of radiation treatment of additional foods. When carried out according to established good manufacturing practices, food irradiation yields safe, wholesome foods. The irradiated product may be often chemically or microbiologically [open quotes]safer[close quotes] than the nonirradiated product. This paper presents several areas of scientific research in which more information would facilitate the expansion of this technology and points out major areas of concern. The question of the public acceptance of foods that have been treated with ionizing radiation is discussed only briefly in order to make the presentation complete.

  4. Research Findings on Overactive Bladder

    PubMed Central

    Patra, Phani B.; Patra, Sayani

    2015-01-01

    Several physiopathologic conditions lead to the manifestation of overactive bladder (OAB). These conditions include ageing, diabetes mellitus, bladder outlet obstruction, spinal cord injury, stroke and brain injury, Parkinson's disease, multiple sclerosis, interstitial cystitis, stress and depression. This review has discussed research findings in human and animal studies conducted on the above conditions. Several structural and functional changes under these conditions have not only been observed in the lower urinary tract, but also in the brain and spinal cord. Significant changes were observed in the following areas: neurotransmitters, prostaglandins, nerve growth factor, Rho-kinase, interstitial cells of Cajal, and ion and transient receptor potential channels. Interestingly, alterations in these areas showed great variation in each of the conditions of the OAB, suggesting that the pathophysiology of the OAB might be different in each condition of the disease. It is anticipated that this review will be helpful for further research on new and specific drug development against OAB. PMID:26195957

  5. Human Health Effects of Tetrachloroethylene: Key Findings and Scientific Issues

    PubMed Central

    Hogan, Karen A.; Scott, Cheryl Siegel; Cooper, Glinda S.; Bale, Ambuja S.; Kopylev, Leonid; Barone, Stanley; Makris, Susan L.; Glenn, Barbara; Subramaniam, Ravi P.; Gwinn, Maureen R.; Dzubow, Rebecca C.; Chiu, Weihsueh A.

    2014-01-01

    Background: The U.S. Environmental Protection Agency (EPA) completed a toxicological review of tetrachloroethylene (perchloroethylene, PCE) in February 2012 in support of the Integrated Risk Information System (IRIS). Objectives: We reviewed key findings and scientific issues regarding the human health effects of PCE described in the U.S. EPA’s Toxicological Review of Tetrachloroethylene (Perchloroethylene). Methods: The updated assessment of PCE synthesized and characterized a substantial database of epidemiological, experimental animal, and mechanistic studies. Key scientific issues were addressed through modeling of PCE toxicokinetics, synthesis of evidence from neurological studies, and analyses of toxicokinetic, mechanistic, and other factors (tumor latency, severity, and background rate) in interpreting experimental animal cancer findings. Considerations in evaluating epidemiological studies included the quality (e.g., specificity) of the exposure assessment methods and other essential design features, and the potential for alternative explanations for observed associations (e.g., bias or confounding). Discussion: Toxicokinetic modeling aided in characterizing the complex metabolism and multiple metabolites that contribute to PCE toxicity. The exposure assessment approach—a key evaluation factor for epidemiological studies of bladder cancer, non-Hodgkin lymphoma, and multiple myeloma—provided suggestive evidence of carcinogenicity. Bioassay data provided conclusive evidence of carcinogenicity in experimental animals. Neurotoxicity was identified as a sensitive noncancer health effect, occurring at low exposures: a conclusion supported by multiple studies. Evidence was integrated from human, experimental animal, and mechanistic data sets in assessing adverse health effects of PCE. Conclusions: PCE is likely to be carcinogenic to humans. Neurotoxicity is a sensitive adverse health effect of PCE. Citation: Guyton KZ, Hogan KA, Scott CS, Cooper GS, Bale AS

  6. Beyond microarrays: Finding key transcription factors controlling signal transduction pathways

    PubMed Central

    Kel, Alexdander; Voss, Nico; Jauregui, Ruy; Kel-Margoulis, Olga; Wingender, Edgar

    2006-01-01

    Background Massive gene expression changes in different cellular states measured by microarrays, in fact, reflect just an "echo" of real molecular processes in the cells. Transcription factors constitute a class of the regulatory molecules that typically require posttranscriptional modifications or ligand binding in order to exert their function. Therefore, such important functional changes of transcription factors are not directly visible in the microarray experiments. Results We developed a novel approach to find key transcription factors that may explain concerted expression changes of specific components of the signal transduction network. The approach aims at revealing evidence of positive feedback loops in the signal transduction circuits through activation of pathway-specific transcription factors. We demonstrate that promoters of genes encoding components of many known signal transduction pathways are enriched by binding sites of those transcription factors that are endpoints of the considered pathways. Application of the approach to the microarray gene expression data on TNF-alpha stimulated primary human endothelial cells helped to reveal novel key transcription factors potentially involved in the regulation of the signal transduction pathways of the cells. Conclusion We developed a novel computational approach for revealing key transcription factors by knowledge-based analysis of gene expression data with the help of databases on gene regulatory networks (TRANSFAC® and TRANSPATH®). The corresponding software and databases are available at . PMID:17118134

  7. Air Research Program: Key Pathways research track

    EPA Science Inventory

    The pathways research track applies animal, cellular, and human studies to discern whether there is a common molecular mechanism (e.g. production of oxidative stress, phosphatase inhibition, disruption of iron homeostasis) through which air pollutants induce toxicity of air pollu...

  8. Human Health Effects of Biphenyl: Key Findings and Scientific Issues

    PubMed Central

    Li, Zheng; Hogan, Karen A.; Cai, Christine; Rieth, Susan

    2015-01-01

    Background: In support of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) has evaluated the human health hazards of biphenyl exposure. Objectives: We review key findings and scientific issues regarding expected human health effects of biphenyl. Methods: Scientific literature from 1926 through September 2012 was critically evaluated to identify potential human health hazards associated with biphenyl exposure. Key issues related to the carcinogenicity and noncancer health hazards of biphenyl were examined based on evidence from experimental animal bioassays and mechanistic studies. Discussion: Systematic consideration of experimental animal studies of oral biphenyl exposure took into account the variety of study designs (e.g., study sizes, exposure levels, and exposure durations) to reconcile differing reported results. The available mechanistic and toxicokinetic evidence supports the hypothesis that male rat urinary bladder tumors arise through urinary bladder calculi formation but is insufficient to hypothesize a mode of action for liver tumors in female mice. Biphenyl and its metabolites may induce genetic damage, but a role for genotoxicity in biphenyl-induced carcinogenicity has not been established. Conclusions: The available health effects data for biphenyl provides suggestive evidence for carcinogenicity in humans, based on increased incidences of male rat urinary bladder tumors at high exposure levels and on female mouse liver tumors. Kidney toxicity is also a potential human health hazard of biphenyl exposure. Citation: Li Z, Hogan KA, Cai C, Rieth S. 2016. Human health effects of biphenyl: key findings and scientific issues. Environ Health Perspect 124:703–712; http://dx.doi.org/10.1289/ehp.1509730 PMID:26529796

  9. "State of the Nation": A Discussion of Some of the Project's Key Findings

    ERIC Educational Resources Information Center

    Earley, Peter

    2010-01-01

    This paper considers several of the key findings of the State of the Nation research. Specific reference is made to three areas--impact evaluation, strategic leadership of professional development, and barriers and constraints to effective CPD practice--which are considered with reference to findings from the other TDA-funded projects conducted at…

  10. AN INTEGRATED SYNTHESIS OF KEY AND POLICY RELEVANT FINDINGS FROM EPA'S SUPERSITES PROGRAM AND RELATED STUDIES

    EPA Science Inventory

    This presentation provides an overview and initial insights into the findings based on results from EPA's PM Supersites Program and related studies. Many key atmospheric sciences findings have been identified through the research conducted during the last five years as part of t...

  11. Human Health Effects of Trichloroethylene: Key Findings and Scientific Issues

    PubMed Central

    Jinot, Jennifer; Scott, Cheryl Siegel; Makris, Susan L.; Cooper, Glinda S.; Dzubow, Rebecca C.; Bale, Ambuja S.; Evans, Marina V.; Guyton, Kathryn Z.; Keshava, Nagalakshmi; Lipscomb, John C.; Barone, Stanley; Fox, John F.; Gwinn, Maureen R.; Schaum, John; Caldwell, Jane C.

    2012-01-01

    Background: In support of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) completed a toxicological review of trichloroethylene (TCE) in September 2011, which was the result of an effort spanning > 20 years. Objectives: We summarized the key findings and scientific issues regarding the human health effects of TCE in the U.S. EPA’s toxicological review. Methods: In this assessment we synthesized and characterized thousands of epidemiologic, experimental animal, and mechanistic studies, and addressed several key scientific issues through modeling of TCE toxicokinetics, meta-analyses of epidemiologic studies, and analyses of mechanistic data. Discussion: Toxicokinetic modeling aided in characterizing the toxicological role of the complex metabolism and multiple metabolites of TCE. Meta-analyses of the epidemiologic data strongly supported the conclusions that TCE causes kidney cancer in humans and that TCE may also cause liver cancer and non-Hodgkin lymphoma. Mechanistic analyses support a key role for mutagenicity in TCE-induced kidney carcinogenicity. Recent evidence from studies in both humans and experimental animals point to the involvement of TCE exposure in autoimmune disease and hypersensitivity. Recent avian and in vitro mechanistic studies provided biological plausibility that TCE plays a role in developmental cardiac toxicity, the subject of substantial debate due to mixed results from epidemiologic and rodent studies. Conclusions: TCE is carcinogenic to humans by all routes of exposure and poses a potential human health hazard for noncancer toxicity to the central nervous system, kidney, liver, immune system, male reproductive system, and the developing embryo/fetus. PMID:23249866

  12. Researchers Find a Mechanism for Schizophrenia

    MedlinePlus

    ... exit disclaimer . Subscribe Researchers Find a Mechanism for Schizophrenia Scientists uncovered a mechanism behind genetic variations previously linked to schizophrenia. The findings may lead to new clinical approaches. ...

  13. Keys to Survival: Highlights in Resilience Research.

    ERIC Educational Resources Information Center

    Burger, Joseph V.

    1994-01-01

    Presents key themes from expanding literature on resilience, drawing from both psychological research and narratives of survivors. Focuses on Kauai study, landmark 30-year longitudinal study on resilience in 698 infants. Also examines survivors of child abuse, distinguishes between unhealthy and healthy resilience, discusses issues of separation…

  14. Responding to Recession: IT Funding and Cost Management in Higher Education. Key Findings

    ERIC Educational Resources Information Center

    Goldstein, Philip J.

    2010-01-01

    This document presents the key findings from "Responding to Recession: IT Funding and Cost Management in Higher Education", the 2010 ECAR (EDUCAUSE Center for Applied Research) study of how the economic recession is impacting information technology (IT) organizations and operations in higher education. The study was designed to address the…

  15. Alternative IT Sourcing Strategies: From the Campus to the Cloud. ECAR Key Findings

    ERIC Educational Resources Information Center

    Goldstein, Philip J.

    2009-01-01

    This document presents the key findings from the 2009 ECAR (EDUCAUSE Center for Applied Research) study, "Alternative IT Sourcing Strategies: From the Campus to the Cloud," by Philip J. Goldstein. The study explores a multitude of strategies used by colleges and university information technology organizations to deliver the breadth of technologies…

  16. The ECAR Study of Undergraduate Students and Information Technology, 2010. Key Findings

    ERIC Educational Resources Information Center

    Smith, Shannon D.; Caruso, Judith Borreson

    2010-01-01

    This document presents the key findings from "The ECAR Study of Undergraduate Students and Information Technology, 2010". Since 2004, the annual ECAR (EDUCAUSE Center for Applied Research) study of undergraduate students and information technology has sought to shed light on how information technology affects the college experience. We ask…

  17. 76 FR 47589 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI) has... Research Center: Based on the Respondent's acceptance of ORI's research misconduct findings, ORI found...

  18. A Mid-DESD Review: Key Findings and Ways Forward

    ERIC Educational Resources Information Center

    Wals, Arjen E. J.

    2009-01-01

    This article lists the key outcomes and recommendations of Phase I of the monitoring and evaluation of the DESD. Phase I focused on a review of the structures, provisions and conditions countries and regions have put in place in order to facilitate the development and implementation of ESD. The author also touches upon the constraints and…

  19. Space Situational Awareness (SSA) research findings

    NASA Astrophysics Data System (ADS)

    Richmond, D.

    Space Situational Awareness (SSA) is the foundation for space superiority and has become a national priority. Providing full SSA requires knowledge of space and ground assets along with communication links between these assets. It also requires an understanding of potential events and threats that may affect these assets. This paper summarizes the findings resulting from a research environment established to explore SSA issues. Non-traditional data sources available on the internet are identified along with methods to mine relevant data. Algorithms to augment this data with value added processing were evaluated and key features are presented. These include all-on-all conjunction analysis utilizing analytical distributed processing approaches and maneuver detection utilizing an approach described in the AMOS 2007 paper "Satellite Maneuver Detection Using Two-line Elements". Data fusion techniques are presented which were utilized to evaluate space launches, enhance maneuver detection capabilities, characterize events and determine possible intent. Several visualization approaches were explored and the key features/limitations are discussed to include performance consideration, event models between visualization components, and data needs at the tactical, operational, and strategic levels. Data dissemination approaches utilizing a Service Oriented Architecture (SOA) are highlighted along with challenges such as Multiple Levels of Security associated with the data. Dependencies between visualization and dissemination that impact the system's performance are discussed. Alternatives to balance system performance and application of a User Defined Operational Picture (UDOP) are explored.

  20. Editorial Decisions May Perpetuate Belief in Invalid Research Findings

    PubMed Central

    Eriksson, Kimmo; Simpson, Brent

    2013-01-01

    Social psychology and related disciplines are seeing a resurgence of interest in replication, as well as actual replication efforts. But prior work suggests that even a clear demonstration that a finding is invalid often fails to shake acceptance of the finding. This threatens the full impact of these replication efforts. Here we show that the actions of two key players – journal editors and the authors of original (invalidated) research findings – are critical to the broader public’s continued belief in an invalidated research conclusion. Across three experiments, we show that belief in an invalidated finding falls sharply when a critical failed replication is published in the same – versus different – journal as the original finding, and when the authors of the original finding acknowledge that the new findings invalidate their conclusions. We conclude by discussing policy implications of our key findings. PMID:24023863

  1. 78 FR 941 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-07

    ... finds that the Respondent knowingly and intentionally: Falsely reported research experiments when the... in normal neurons, when the experiment was not conducted. Falsified Figure 3 of grant application...

  2. The National Television Violence Study: Key Findings and Recommendations.

    ERIC Educational Resources Information Center

    Young Children, 1996

    1996-01-01

    Summarizes findings of the Television Violence Study indicating that the context of much television violence is dangerous to viewers, perpetrators go unpunished in the majority of programs, negative consequences of violence are often ignored, guns feature prominently, and presentation of violence differs greatly across networks and across…

  3. 75 FR 18837 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... senior scientist, Discovery Research, Women's Health, Wyeth Pharmaceuticals, engaged in research... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI)...

  4. 75 FR 18836 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI) and... graduate student, IU, engaged in research misconduct in research supported by National Center...

  5. 76 FR 64947 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. Notice is hereby given that the Office of Research Integrity (ORI) has taken..., Department of Chemistry, UP, engaged in research misconduct in research supported by National Institute...

  6. 76 FR 68460 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI) has... Resident Physician at UVA Medical Center, engaged in research misconduct by plagiarizing research...

  7. 77 FR 76491 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI) has..., engaged in research misconduct in research supported by National Institute of General Medical...

  8. 77 FR 125 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-03

    ... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI) has... conducted by ORI in its oversight review, ORI found that Dr. Mahesh Visvanathan, Research...

  9. 77 FR 46438 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-03

    ... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI) has..., former Director of the Laboratory of Glycoimmunotheraphy, JWCI, engaged in research misconduct...

  10. 78 FR 21125 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-09

    ... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI) has... found by a preponderance of the evidence that Dr. Andrew Aprikyan, former Research Assistant...

  11. 78 FR 67363 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI) has... Professor of Surgery and Pathology, Schulich School of Medicine and Dentistry, WU, engaged in...

  12. The Children's Hearings Project Research Findings. A Summary Report.

    ERIC Educational Resources Information Center

    Merry, Sally E.; And Others

    Since 1980 the Children's Hearings Project (CHP) in Cambridge, Massachusetts, has offered status offenders and their families mediation as an alternative to the courts. This report describes CPH's origins and summarizes the results of an extensive research study conducted during the first 2 years of its operation. The key findings were: (1)…

  13. Why most published research findings are false.

    PubMed

    Ioannidis, John P A

    2005-08-01

    There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of true to no relationships among the relationships probed in each scientific field. In this framework, a research finding is less likely to be true when the studies conducted in a field are smaller; when effect sizes are smaller; when there is a greater number and lesser preselection of tested relationships; where there is greater flexibility in designs, definitions, outcomes, and analytical modes; when there is greater financial and other interest and prejudice; and when more teams are involved in a scientific field in chase of statistical significance. Simulations show that for most study designs and settings, it is more likely for a research claim to be false than true. Moreover, for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias. In this essay, I discuss the implications of these problems for the conduct and interpretation of research. PMID:16060722

  14. 77 FR 11538 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary..., which is critical to normal brain development. Specifically: a. In the VZ/SZ panel (upper row, right... that gestational alcohol exposure had an effect on brain development by affecting the way...

  15. 77 FR 38632 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-28

    ... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary... Exposure to the Widely Used Herbicide, Atrazine: Altered Function and Loss of Neurons in Brain Monamine... experiments carried out at UMDNJ between 2004 and 2006; Falsifying a bar graph representing brain...

  16. Making Professional Decisions in Research: Measurement and Key Predictors.

    PubMed

    Antes, Alison L; Chibnall, John T; Baldwin, Kari A; Tait, Raymond C; Vander Wal, Jillon S; DuBois, James M

    2016-01-01

    The professional decision-making in research (PDR) measure was administered to 400 National Institutes of Health (NIH)-funded and industry-funded investigators, along with measures of cynicism, moral disengagement, compliance disengagement, impulsivity, work stressors, knowledge of responsible conduct of research (RCR), and socially desirable response tendencies. Negative associations were found for the PDR and measures of cynicism, moral disengagement, and compliance disengagement, while positive associations were found for the PDR and RCR knowledge and positive urgency, an impulsivity subscale. PDR scores were not related to socially desirable responding, or to measures of work stressors and the remaining impulsivity subscales. In a multivariate logistic regression analysis, lower moral disengagement scores, higher RCR knowledge, and identifying the United States as one's nation of origin emerged as key predictors of stronger performance on the PDR. The implications of these findings for understanding the measurement of decision-making in research and future directions for research and RCR education are discussed. PMID:27093003

  17. Yucca Mountain Socioeconomic Project: The 1991 Nevada State telephone survey: Key findings

    SciTech Connect

    Flynn, J.H.; Mertz, C.K.; Slovic, P.

    1991-05-01

    The 1991 Nevada State Telephone Survey was implemented by Decision Research on behalf of the State of Nevada, Agency for Nuclear Projects/Nuclear Waste Project Office (NWPO) as part of an ongoing socioeconomic impact assessment study. The scope of this survey was considerably smaller than a previous survey conducted in 1989 and focused more upon public evaluations of the Yucca Mountain repository program and the trust Nevadans currently addressing the siting issues. In order to provide place in key public officials who are Longitudinal data on the repository program, the 1991 questionnaire consisted of questions that were used in the 1989 NWPO survey which was conducted by Mountain West Research. As a result, the findings from this survey are compared with analogous items from the 1989 survey, and with the results from a survey commissioned by the Las Vegas Review-Journal and reported in their issue of October 21, 1990. The Review-Journal survey was conducted by Bruce Merri11 of the Arizona State University Media Research Center. A more complete comparison of the 1989 and 1991 surveys sponsored by NWPO is possible since the researchers at Decision Research had access to both these databases. The only source of information for the Review-Journal findings was the articles published in the Fall, 1990. The findings of the 1991 survey show that Nevadans oppose the federal government attempts to locate a high-level radioactive waste repository at Yucca Mountain. They support a policy of opposition on the part of Nevada officials. They believe that Nevadans should have the final say in whether to accept the repository or not, and they reject the proposition that benefits from the repository program will outweigh the harms. These findings are very similar to survey results from 1989 and 1990 and once again demonstrate very widespread public opposition by Nevadans to the current federal repository program.

  18. Research on Key Technologies of Cloud Computing

    NASA Astrophysics Data System (ADS)

    Zhang, Shufen; Yan, Hongcan; Chen, Xuebin

    With the development of multi-core processors, virtualization, distributed storage, broadband Internet and automatic management, a new type of computing mode named cloud computing is produced. It distributes computation task on the resource pool which consists of massive computers, so the application systems can obtain the computing power, the storage space and software service according to its demand. It can concentrate all the computing resources and manage them automatically by the software without intervene. This makes application offers not to annoy for tedious details and more absorbed in his business. It will be advantageous to innovation and reduce cost. It's the ultimate goal of cloud computing to provide calculation, services and applications as a public facility for the public, So that people can use the computer resources just like using water, electricity, gas and telephone. Currently, the understanding of cloud computing is developing and changing constantly, cloud computing still has no unanimous definition. This paper describes three main service forms of cloud computing: SAAS, PAAS, IAAS, compared the definition of cloud computing which is given by Google, Amazon, IBM and other companies, summarized the basic characteristics of cloud computing, and emphasized on the key technologies such as data storage, data management, virtualization and programming model.

  19. Key Findings from a National Internet Survey of 400 Teachers and 95 Principals Conducted November 12-21, 2008

    ERIC Educational Resources Information Center

    McCleskey, Nicole

    2010-01-01

    This paper presents the key findings from a national Internet survey of 400 teachers and 95 principals. This survey was conducted November 12-21, 2008. The sample was based on a list provided by EMI Surveys, a custom online research sample provider with an extensive portfolio of projects. The margin of error for a sample of 495 interviews is [plus…

  20. Putting Research Findings into Clinical Practice

    PubMed Central

    Bhargava, Deepa; Al-Lawatia, Zainab; Al-Abri, Rashid; Bhargava, Kamlesh

    2012-01-01

    Objectives: A perception exists that clinicians in Oman are reluctant to adopt evidence-based practice (EBP). This pilot study was undertaken to study the feasibility of using EBP pathways at the point of care in otorhinolaryngology head and neck surgery. The ultimate aim was to facilitate EBP with the probability of developing a new system for implementing research findings/translational research at the clinical point of care. Methods: A cross-sectional prospective questionnaire pilot survey of clinicians at Sultan Qaboos University Hospital (SQUH), Oman, a tertiary care medical centre, was undertaken. Respondents included 135 physicians and surgeons with between 3 months and 25 years of clinical experience and included personnel ranging from interns to senior consultants, in areas ranging from primary care to specialist care. Results: Of those polled, 90% (95% confidence interval (CI) 85–95%) either strongly agreed or agreed that evidence-based practice protocols (EBPP) could help in decision making. A total of 87.4% of participants (95% CI 81.8–93%) either strongly agreed or agreed that EBPPs can improve clinical outcomes; 91.8% of participants (95% CI 87.2–96.4%) would use and apply EBPP in day-to-day care if they were available at the point of care and embedded in the hospital information system. Conclusions: The perception that clinicians at SQUH are reluctant to adopt EBP is incorrect. The introduction of EBP pathways is very feasible at the primary care level. Institutional support for embedding EBP in hospital information systems is needed as well as further outcome research to assess the improvement in quality of care. PMID:22548137

  1. Nest predation research: Recent findings and future perspectives

    USGS Publications Warehouse

    Chalfoun, Anna L.; Ibanez-Alamo, J. D.; Magrath, R. D.; Schmidt, Kenneth A.; Thomson, R. L.; Oteyza, Juan C.; Haff, T. M.; Martin, T.E.

    2016-01-01

    Nest predation is a key source of selection for birds that has attracted increasing attention from ornithologists. The inclusion of new concepts applicable to nest predation that stem from social information, eavesdropping or physiology has expanded our knowledge considerably. Recent methodological advancements now allow focus on all three players within nest predation interactions: adults, offspring and predators. Indeed, the study of nest predation now forms a vital part of avian research in several fields, including animal behaviour, population ecology, evolution and conservation biology. However, within nest predation research there are important aspects that require further development, such as the comparison between ecological and evolutionary antipredator responses, and the role of anthropogenic change. We hope this review of recent findings and the presentation of new research avenues will encourage researchers to study this important and interesting selective pressure, and ultimately will help us to better understand the biology of birds.

  2. Russian research capabilities: Findings of site visits

    SciTech Connect

    Wester, D.W.

    1994-02-01

    In June 1993, a proposal was presented to the International Environmental Institute (IEI) in Kennewick, Washington, to establish cooperation and coordination to further pursue the interests of the United States of America and the Republic of Russia in the application and promotion of environmental technology; characterization, treatment, handling, isolation, and disposal of hazardous and radioactive materials; conversion of defense sites to other purposes; and technology transfer, cooperative programs, joint technology development and contractual research. In response to this proposal, IEI and Pacific Northwest Laboratory (PNL) jointly provided funding to send Dr. Dennis W. Wester on a fact-finding mission to Novosibirsk, Moscow, and St. Petersburg, Russia. The trip covered a period of eight weeks, six of which were spent in Novosibirsk and adjoining or related cities and one of which was spent in each of Moscow and St. Petersburg. The general objectives of the trip were to establish a basis for cooperation between IEI and the Russian Academy of Sciences (RAS) for future coordination of mutual interests and objectives such as technology acquisition, development, demonstration, application, and commercialization; use of capabilities and assets developed by the U.S. Department of Energy (DOE) and the RAS; and expediting of cooperative agreements, personnel exchanges, joint ventures and other contractual relationships. The particular objectives of this trip were to evaluate the capabilities of the RAS to satisfy the technology needs associated with the cleanup of the Hanford Site and similar sites in the U.S. and to evaluate the expediency of establishing an IEI presence in Russia.

  3. Monitoring the Future National Results on Adolescent Drug Use: Overview of Key Findings, 2001.

    ERIC Educational Resources Information Center

    Johnston, Lloyd D.; O'Malley, Patrick M.; Bachman, Jerald G.

    This report presents an overview of the key findings from the Monitoring the Future 2001 nationwide survey of 8th, 10th, and 12th grade students. A particular emphasis is placed on recent trends in the use of licit and illicit drugs. Trends in the levels of perceived risk and personal disapproval associated with each drug--which this study has…

  4. Monitoring the Future: National Results on Adolescent Drug Use. Overview of Key Findings, 2002.

    ERIC Educational Resources Information Center

    Michigan Univ., Ann Arbor. Inst. for Social Research.

    This report presents an overview of the key findings from the Monitoring the Future 2002 nationwide survey of 8th, 10th, and 12th grade students. A particular emphasis is placed on recent trends in the use of licit and illicit drugs. Trends in the levels of perceived risk and personal disapproval associated with each drug--which this study has…

  5. Teaching Teachers for the Future (TTF) Project TPACK Survey: Summary of the Key Findings

    ERIC Educational Resources Information Center

    Finger, Glenn; Jamieson-Proctor, Romina; Cavanagh, Rob; Albion, Peter; Grimbeek, Peter; Bond, Trevor; Fitzgerald, Robert; Romeo, Geoff; Lloyd, Margaret

    2013-01-01

    This paper presents a summary of the key findings of the TTF TPACK Survey developed and administered for the Teaching the Teachers for the Future (TTF) Project implemented in 2011. The TTF Project, funded by an Australian Government ICT Innovation Fund grant, involved all 39 Australian Higher Education Institutions which provide initial teacher…

  6. Language Learning at Key Stage 2: Findings from a Longitudinal Study

    ERIC Educational Resources Information Center

    Cable, Carrie; Driscoll, Patricia; Mitchell, Rosamond; Sing, Sue; Cremin, Teresa; Earl, Justine; Eyres, Ian; Holmes, Bernardette; Martin, Cynthia; Heins, Barbara

    2012-01-01

    This paper discusses some of the findings from a 3-year longitudinal study of language learning in the upper stage of English primary schools, i.e. at Key Stage 2. This largely qualitative study (commissioned by the then Department for Children, Schools and Families) was designed to explore and document developing provision and practice in a…

  7. 78 FR 5454 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... phospholipase A2 IIA is Up-regulated by TNF- and IL-1 / after Transient Focal Cerebral Ischemia in Rat.'' Brain Research 1134:199- 205, 2007 (hereafter referred to as the ``Brain Research paper''), as the sPLA 2 -IIA... the JBC paper and Figure 2A and 2C of the Brain Research paper by rearranging the bands such that...

  8. 77 FR 5254 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ...Notice is hereby given that the Office of Research Integrity (ORI) has taken final action in the following case: Calleen S. Zach, Creighton University: Based on evidence obtained from Creighton University (CU) and additional evidence gathered by the Office of Research Integrity (ORI) during its oversight review, ORI found that Ms. Calleen S. Zach, former Research Assistant and Data Base......

  9. 78 FR 47699 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    ...Notice is hereby given that the Office of Research Integrity (ORI) has taken final action in the following case: Pratima Karnik, Ph.D., Case Western Reserve University: Based on the admission of the Respondent, ORI found that Dr. Pratima Karnik, Assistant Professor, Department of Dermatology, Case Western Reserve University (CWRU), engaged in research misconduct in research submitted to the......

  10. Exposure prediction approaches used in air pollution epidemiology studies: Key findings and future recommendations

    PubMed Central

    Baxter, Lisa K.; Dionisio, Kathie L.; Burke, Janet; Sarnat, Stefanie Ebelt; Sarnat, Jeremy A.; Hodas, Natasha; Rich, David Q.; Turpin, Barbara J.; Jones, Rena R.; Mannshardt, Elizabeth; Kumar, Naresh; Beevers, Sean D.; Özkaynak, Halûk

    2014-01-01

    Many epidemiologic studies of the health effects of exposure to ambient air pollution use measurements from central-site monitors as their exposure estimate. However, measurements from central-site monitors may lack the spatial and temporal resolution required to capture exposure variability in a study population, thus resulting in exposure error and biased estimates. Articles in this dedicated issue examine various approaches to predict or assign exposures to ambient pollutants. These methods include: combining existing central-site pollution measurements with local- and/or regional-scale air quality models to create new or “hybrid” models for pollutant exposure estimates, and using exposure models to account for factors such as infiltration of pollutants indoors and human activity patterns. Key findings from these articles are summarized to provide lessons learned and recommendations for additional research on improving exposure estimation approaches for future epidemiological studies. In summary, when compared to use of central-site monitoring data, the enhanced spatial resolution of air quality or exposure models can have an impact on resultant health effect estimates, especially for pollutants derived from local sources such as traffic (e.g. EC, CO, and NOx). In addition, the optimal exposure estimation approach also depends upon the epidemiological study design. We recommend that future research develop pollutant-specific infiltration data (including for PM species), and improve existing data on human time-activity patterns, and exposure to local source (e.g. traffic), in order to enhance human exposure modeling estimates. We also recommend comparing how various approaches to exposure estimation characterize relationships between multiple pollutants in time and space, and investigating the impact of improved exposure estimates in chronic health studies. PMID:24084756

  11. Finding Exemplars of Research on Academic Programs.

    ERIC Educational Resources Information Center

    Toombs, William

    Exemplars of research on academic programs are considered in relation to the qualities of research and types of information used as a framework for analysis. It is suggested that serious investigations of the postsecondary curriculum are characterized by: efforts to move from particularistic approaches to the stipulation of universalistic…

  12. 77 FR 40059 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ...Notice is hereby given that the Office of Research Integrity (ORI) has taken final action in the following case: Sinae Kim, Ph.D., Emory University: Based on the report of an investigation conducted by Emory University (EU) and additional analysis conducted by ORI in its oversight review, ORI found that Dr. Sinae Kim, former Postdoctoral Fellow, Department of Medicine, EU, engaged in research......

  13. 76 FR 23599 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... intentionally tampered with research materials related to five (5) immunoprecipitation/Western blot experiments and switched the labels on four (4) cell culture dishes for cells used in the same type of...

  14. Writing and Publishing Your Research Findings

    PubMed Central

    Quinn, Charles T.; Rush, A. John

    2014-01-01

    Writing clearly is critical to the success of your scientific career. Unfortunately, this skill is not taught in medical school or postgraduate training. This article summarizes our approach to the writing and publication of your research. Here we focus on empirical or experimental reports of translational and clinically oriented research. We review the process of choosing what to write, how to write it clearly, and how to navigate the process of submission and publication. PMID:19491626

  15. Multi-detector CT assessment in pulmonary hypertension: techniques, systematic approach to interpretation and key findings

    PubMed Central

    Lewis, Gareth; Reynolds, John H.; Ganeshan, Arul; Ment, Jerome

    2015-01-01

    Pulmonary arterial hypertension (PAH) may be suspected based on the clinical history, physical examination and electrocardiogram findings but imaging is usually central to confirming the diagnosis, establishing a cause and guiding therapy. The diagnostic pathway of PAH involves a variety of complimentary investigations of which computed tomography pulmonary angiography (CTPA) has established a central role both in helping identify an underlying cause for PAH and assessing resulting functional compromise. In particular CTPA is considered as the gold standard technique for the diagnosis of thromboembolic disease. This article reviews the CTPA evaluation in PAH, describing CTPA techniques, a systematic approach to interpretation and spectrum of key imaging findings. PMID:26029645

  16. 76 FR 63621 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ...Notice is hereby given that the Office of Research Integrity (ORI) has taken final action in the following case: Nicola Solomon, Ph.D., University of Michigan Medical School: Based on an investigation conducted by the University of Michigan Medical School (UMMS) and a preliminary analysis conducted by ORI, ORI found that Dr. Nicola Solomon, former postdoctoral scholar, Department of Human......

  17. Educational Research: Biologists Finding Their Voice

    ERIC Educational Resources Information Center

    Orsmond, Paul

    2007-01-01

    Since the publication of the Dearing report (1997) there has been an increasing emphasis on the quality of teaching and learning provision within higher education institutions (HEIs). This focus on provision has in turn generated much educational research into "approaches" to both teaching practice and student learning within higher education…

  18. 78 FR 25274 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ...Notice is hereby given that the Office of Research Integrity (ORI) has taken final action in the following case: Matthew Poore, Advanced Liquid Logic Inc.: Based on the report of an inquiry conducted by Advanced Liquid Logic Inc. (Liquid Logic), the Respondent's admission, and additional analysis conducted by ORI, ORI found that Mr. Matthew Poore, former Technician, Liquid Logic, engaged in......

  19. Researching Women's Groups Findings, Limitations, and Recommendations

    ERIC Educational Resources Information Center

    Leech, Nancy L.; Kees, Nathalie L.

    2005-01-01

    There is not a "typical" women's group, nor are there "typical" women's issues. Every women's group is diverse, with as many viewpoints and perspectives as there are members in the group. Using the group format for women is common practice with many counselors. It is interesting that there has been little empirical research reported on women's…

  20. 78 FR 77467 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... HIV-1 strains, when the original sera were weakly or non-reactive in neutralization assays. Falsified neutralization assay results were widely reported in laboratory meetings, seven (7) national and international... falsified research materials when he provided collaborators with sera for neutralization assays from...

  1. Contemporary research findings on dentine remineralization.

    PubMed

    Zhong, Bo; Peng, Ce; Wang, Guanhong; Tian, Lili; Cai, Qiang; Cui, Fuzhai

    2015-09-01

    Dentine remineralization is important for the treatment of dentine caries and the bonding durability of dentine and resin materials in clinical practice. Early studies of dentine remineralization were mostly based on the classical pathway of crystallization, which involves large-scale deposition of calcium phosphate crystals on collagen and is achieved in a liquid environment containing mineral ions. Results from these studies were unsatisfactory and not suitable for clinical application because they did not simulate the ordering of hydroxyapatite in the collagen fibres of natural teeth. As studies on collagen type I and non-collagenous proteins have advanced, dentine biomimetic remineralization has become a popular research topic and has shifted to processes involving intrafibrillar remineralization, which is more similar to natural tooth formation. The objective of this review was to summarize current theory and research progress as it relates to dentine remineralization. PMID:23955967

  2. 77 FR 76041 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ...Notice is hereby given that the Office of Research Integrity (ORI) has taken final action in the following case: Terry S. Elton, Ph.D., The Ohio State University: Based on the reports of two investigations conducted by The Ohio State University (OSU) and additional analysis conducted by ORI in its oversight review, ORI found that Dr. Terry S. Elton, Professor, College of Pharmacy and Davis......

  3. Latest research findings from petite sismique trials

    SciTech Connect

    Belesky, R.M.; Bieniawski, Z.T.; Greenfield, R.J.

    1984-01-01

    Research on a novel in-situ technique known as petite sismique is discussed. This geophysical method is capable of estimating the static deformation modules of a rock mass. The petite-sismique technique utilizes a seismic-refraction survey stressing a correlation between shear-wave frequency and the static deformation modulus. Although the technique was introduced in 1967, petite sismique has not been used extensively due to difficulties in shear-wave generation and detection. Recent developments in geophysical instrumentation provided an opportunity to evaluate better the technique in this study. With the objective of assessing the deformation modulus, field trials were conducted in coal and limestone mines. Despite attempts to develop a reliable shear-wave source, difficulties in frequency determinations persisted due to source characteristics and receiver resonance. A limited number of shear-wave-frequency observations did not confirm the originally documented relationship between shear-wave frequency and the static deformation modulus. The indicated discrepancy is attributed to differences in characteristics of the sources used in the two studies. Arising out of this research are equipment modifications and procedural recommendations which should improve the chances for success in future studies.

  4. 40 CFR 63.2831 - Where can I find definitions of key words used in this subpart?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 13 2014-07-01 2014-07-01 false Where can I find definitions of key words used in this subpart? 63.2831 Section 63.2831 Protection of Environment ENVIRONMENTAL PROTECTION... key words used in this subpart? You can find definitions of key words used in this subpart in §...

  5. 40 CFR 63.2831 - Where can I find definitions of key words used in this subpart?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 13 2013-07-01 2012-07-01 true Where can I find definitions of key words used in this subpart? 63.2831 Section 63.2831 Protection of Environment ENVIRONMENTAL PROTECTION... key words used in this subpart? You can find definitions of key words used in this subpart in §...

  6. 40 CFR 63.2831 - Where can I find definitions of key words used in this subpart?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 13 2012-07-01 2012-07-01 false Where can I find definitions of key words used in this subpart? 63.2831 Section 63.2831 Protection of Environment ENVIRONMENTAL PROTECTION... key words used in this subpart? You can find definitions of key words used in this subpart in §...

  7. Institutional Research: The Key to Successful Enrollment Management.

    ERIC Educational Resources Information Center

    Clagett, Craig A.

    Enrollment management includes the processes and activities that influence the size, shape, and characteristics of a student body by directing institutional efforts in marketing, recruitment, admissions, pricing, and financial aid. Institutional research plays an essential, if not the key, role in enrollment management. This report discusses the…

  8. Acamprosate: recent findings and future research directions.

    PubMed

    Mann, Karl; Kiefer, Falk; Spanagel, Rainer; Littleton, John

    2008-07-01

    This article explores the mechanisms of action and the potential responder profile of acamprosate, a compound efficacious in relapse prevention of alcoholism. New evidence at the molecular and cellular level suggests that acamprosate attenuates hyper-glutamatergic states that occur during early abstinence and involves iono (NMDA)- and metabotrotropic (mGluR5) glutamate receptors along with augmented intracellular calcium release and electrophysiological changes. Thus mutant mice with enhanced glutamate levels exhibit higher alcohol consumption than wild type mice and respond better to acamprosate, demonstrating that acamprosate acts mainly on a hyper-glutamatergic system. This mode of action further suggests that acamprosate exhibits neuroprotective properties. In rats, cue-induced reinstatement behavior is significantly reduced by acamprosate treatment whereas cue-induced craving responses in alcohol-dependent patients seem not to be affected by this treatment. An ongoing study ("Project Predict") defines specific responder profiles for an individualized use of acamprosate and naltrexone. Neurophysiological as well as psychometric data are used to define 2 groups of patients: "reward cravers" and "relief cravers". While naltrexone should work better in the first group, acamprosate is hypothesized to be efficacious in the latter where withdrawal associated and/or cue induced hyper-glutamatergic states are thought to trigger relapse. Further research should target the definition of subgroups applying endophenotypic approaches, e.g. by detecting a hyperglutamatergic syndrome using MR spectroscopy. PMID:18540918

  9. Monitoring HIV Prevention Programme Outcomes among Key Populations in Kenya: Findings from a National Survey

    PubMed Central

    Musyoki, Helgar; Anthony, John; Kioko, Japheth; Kaosa, Shem; Ogwang, Bernard E.; Githuka, George; Sirengo, Martin; Birir, Sarah; Blanchard, James F.; Muraguri, Nicholas; Isac, Shajy; Moses, Stephen

    2015-01-01

    In preparation for the implementation of the Kenya AIDS Strategic Framework 2014/15-2018/19, the Kenya National AIDS and STI Control Programme facilitated a national polling booth survey as part of a baseline assessment of HIV-related risk behaviours among FSWs, MSM, and PWID, and their utilization of existing preventive interventions, as well as structural factors that may influence KPs’ vulnerability to HIV. The survey was conducted among “key populations” (female sex workers, men who have sex with men, and people who inject drugs) to understand current HIV risk and prevention behaviours, utilization of existing programmes and services, and experiences of violence. In total, 3,448 female sex workers, 1,308 men who have sex with men, and 690 people who inject drugs were randomly selected to participate in polling booth survey sessions from seven priority sites. Survey responses were aggregated and descriptive statistics derived. In general, reported condom use among all key populations was quite high with paying clients, and lower with regular, non-paying partners. Many participants reported unavailability of condoms or clean injecting equipment within the past month. Exposure to, and utilization of, existing HIV prevention services varied significantly among the groups, and was reported least commonly by female sex workers. Encouragingly, approximately three-quarters of all key population members reported receiving an HIV test in the past three months. All key population groups reported experiencing high levels of physical and sexual violence from partners/clients, and/or arrest and violence by law enforcement officials. Although some of the findings are encouraging, there is room for improvement in HIV prevention programmes and services for key populations across Kenya. PMID:26313642

  10. Monitoring HIV Prevention Programme Outcomes among Key Populations in Kenya: Findings from a National Survey.

    PubMed

    Bhattacharjee, Parinita; McClarty, Leigh M; Musyoki, Helgar; Anthony, John; Kioko, Japheth; Kaosa, Shem; Ogwang, Bernard E; Githuka, George; Sirengo, Martin; Birir, Sarah; Blanchard, James F; Muraguri, Nicholas; Isac, Shajy; Moses, Stephen

    2015-01-01

    In preparation for the implementation of the Kenya AIDS Strategic Framework 2014/15-2018/19, the Kenya National AIDS and STI Control Programme facilitated a national polling booth survey as part of a baseline assessment of HIV-related risk behaviours among FSWs, MSM, and PWID, and their utilization of existing preventive interventions, as well as structural factors that may influence KPs' vulnerability to HIV. The survey was conducted among "key populations" (female sex workers, men who have sex with men, and people who inject drugs) to understand current HIV risk and prevention behaviours, utilization of existing programmes and services, and experiences of violence. In total, 3,448 female sex workers, 1,308 men who have sex with men, and 690 people who inject drugs were randomly selected to participate in polling booth survey sessions from seven priority sites. Survey responses were aggregated and descriptive statistics derived. In general, reported condom use among all key populations was quite high with paying clients, and lower with regular, non-paying partners. Many participants reported unavailability of condoms or clean injecting equipment within the past month. Exposure to, and utilization of, existing HIV prevention services varied significantly among the groups, and was reported least commonly by female sex workers. Encouragingly, approximately three-quarters of all key population members reported receiving an HIV test in the past three months. All key population groups reported experiencing high levels of physical and sexual violence from partners/clients, and/or arrest and violence by law enforcement officials. Although some of the findings are encouraging, there is room for improvement in HIV prevention programmes and services for key populations across Kenya. PMID:26313642

  11. Finding Intercultural Business Communication Research Sites in Companies (Doing Research).

    ERIC Educational Resources Information Center

    Driskill, Linda; Shaw, Peggy

    1994-01-01

    Describes important resources for discovering sites for communication research related to the North American Free Trade Agreement (NAFTA), to help identify appropriate companies and contact them. (SR)

  12. 40 CFR 63.1176 - Where can I find definitions of key words used in this subpart?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 11 2014-07-01 2014-07-01 false Where can I find definitions of key words used in this subpart? 63.1176 Section 63.1176 Protection of Environment ENVIRONMENTAL PROTECTION... Production § 63.1176 Where can I find definitions of key words used in this subpart? The definitions of...

  13. 40 CFR 63.1176 - Where can I find definitions of key words used in this subpart?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 11 2013-07-01 2013-07-01 false Where can I find definitions of key words used in this subpart? 63.1176 Section 63.1176 Protection of Environment ENVIRONMENTAL PROTECTION... Production § 63.1176 Where can I find definitions of key words used in this subpart? The definitions of...

  14. 40 CFR 63.1176 - Where can I find definitions of key words used in this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Where can I find definitions of key words used in this subpart? 63.1176 Section 63.1176 Protection of Environment ENVIRONMENTAL PROTECTION... Production § 63.1176 Where can I find definitions of key words used in this subpart? The definitions of...

  15. 40 CFR 63.1176 - Where can I find definitions of key words used in this subpart?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 10 2011-07-01 2011-07-01 false Where can I find definitions of key words used in this subpart? 63.1176 Section 63.1176 Protection of Environment ENVIRONMENTAL PROTECTION... Production § 63.1176 Where can I find definitions of key words used in this subpart? The definitions of...

  16. How the World's Best Schools Stay on Top: Study's Key Findings Pinpoint Practices That Align with Learning Forward

    ERIC Educational Resources Information Center

    Killion, Joellen

    2016-01-01

    Key findings from a new study highlight how Learning Forward's long-standing position on professional learning correlates with practices in high-performing systems in Singapore, Shanghai, Hong Kong, and British Columbia. The purpose of this article is to share key findings from the study so that educators might apply them to strengthening…

  17. 40 CFR 63.1176 - Where can I find definitions of key words used in this subpart?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 11 2012-07-01 2012-07-01 false Where can I find definitions of key words used in this subpart? 63.1176 Section 63.1176 Protection of Environment ENVIRONMENTAL PROTECTION... Production § 63.1176 Where can I find definitions of key words used in this subpart? The definitions of...

  18. Researchers Find 8 Immune Genes in Aggressive Brain Cancer

    MedlinePlus

    ... news/fullstory_159031.html Researchers Find 8 Immune Genes in Aggressive Brain Cancer Discovery might eventually lead ... 25, 2016 (HealthDay News) -- Researchers have identified immune genes that may affect how long people live after ...

  19. Training: Who Needs It? Research Report 1995. Key Issues for Providers.

    ERIC Educational Resources Information Center

    Hotel and Catering Training Co., London (England).

    Aimed at all those involved in the supply of training and vocational education for the hospitality industry, this report summarizes findings of the research report, "Training Who Needs It?" It draws out and explores in more detail key issues relating to the provision of training, support, and related initiatives for the industry. Section 1…

  20. Research on the architecture and key technologies of SIG

    NASA Astrophysics Data System (ADS)

    Fu, Zhongliang; Meng, Qingxiang; Huang, Yan; Liu, Shufan

    2007-06-01

    Along with the development of computer network, Grid has become one of the hottest issues of researches on sharing and cooperation of Internet resources throughout the world. This paper illustrates a new architecture of SIG-a five-hierarchy architecture (including Data Collecting Layer, Grid Layer, Service Layer, Application Layer and Client Layer) of SIG from the traditional three hierarchies (only including resource layer, service layer and client layer). In the paper, the author proposes a new mixed network mode of Spatial Information Grid which integrates CAG (Certificate Authority of Grid) and P2P (Peer to Peer) in the Grid Layer, besides, the author discusses some key technologies of SIG and analysis the functions of these key technologies.

  1. Research Results Ultra-fast Energy Transfer from Monomer to Dimer within a Trimeric Molecule New Progress in Heterogeneous Catalysis Research Key Progress in Research on Terrestrial Carbon Cycle in China A New Progress in Research on the Mechanism of Bio-Invasion New Findings in Anti-viral infection and Control of Inflammation Major Headway in Avian Origin Research New Progress in Gold-Nanoparticle-Based Biochips Topological Insulator Research Made Important Progress Major Progress in Biodiversity Achieved New Developments of Direct Methods in Protein Crystallography Major Progress in China-UK Collaboration on the Causal Relationship between Volcanic Activity and Biological Distinction News in Brief: NSFC set up "Research Fund for Young Foreign Scholars" How Often Does Human DNA Mutate? Research Progress on Colossal Anisotropic Magneto Resistive Effect

    NASA Astrophysics Data System (ADS)

    2009-01-01

    Ultra-fast Energy Transfer from Monomer to Dimer within a Trimeric Molecule New Progress in Heterogeneous Catalysis Research Key Progress in Research on Terrestrial Carbon Cycle in China A New Progress in Research on the Mechanism of Bio-Invasion New Findings in Anti-viral infection and Control of Inflammation Major Headway in Avian Origin Research New Progress in Gold-Nanoparticle-Based Biochips Topological Insulator Research Made Important Progress Major Progress in Biodiversity Achieved New Developments of Direct Methods in Protein Crystallography Major Progress in China-UK Collaboration on the Causal Relationship between Volcanic Activity and Biological Distinction News in Brief: NSFC set up "Research Fund for Young Foreign Scholars" How Often Does Human DNA Mutate? Research Progress on Colossal Anisotropic Magneto Resistive Effect

  2. Key-linked on-line databases for clinical research.

    PubMed

    Müller, Thomas H

    2012-01-01

    Separating patient identification data from clinical data and/or information about biomaterial samples is an effective data protection measure, especially in clinical research employing "on-line", i.e., web-based, data capture. In this paper, we show that this specialised technique can be generalised into a network architecture of interconnected on-line databases potentially serving a variety of purposes. The basic idea of this approach consists of maintaining logical links, i.e., common record keys, between corresponding data structures in pairs of databases while keeping the actual key values hidden from clients. For client systems, simultaneous access to corresponding records is mediated by temporary access tokens. At the relational level, these links are represented by arbitrary unique record keys common to both databases. This architecture allows for integration of related data in different databases without replicating or permanently sharing this data in one place. Each participating on-line database can determine the degree of integration by specifying linkage keys only for those data structures that may be logically connected to other data. Logical links can de designed for specific use cases. In addition, each database controls user access by enforcing its own authorisation scheme. Another advantage is that individual database owners retain considerable leeway in adapting to changing local requirements without compromising the integration into the network. Beyond protecting individual subject identification data, this architecture permits splitting a cooperatively used data pool to achieve many kinds of objectives. Application examples could be clinical registries needing subject contact information for follow-up, biomaterial banks with or without genetic information, and automatic or assisted integration of data from electronic medical records into research data. PMID:22874246

  3. Applications of Classroom Management Research Findings. Research Series No. 154.

    ERIC Educational Resources Information Center

    Putnam, Joyce; Barnes, Henrietta

    This study examined the long-term effects of providing a research-based approach to classroom management through a two-phase staff development process. The process was designed to promote teachers' ability to establish and maintain effective classroom groups. Teachers' uses of group-development principles, cooperative-learning strategies, and…

  4. Structuring Professional Learning to Develop a Culture of Data Use: Aligning Knowledge from the Field and Research Findings

    ERIC Educational Resources Information Center

    Gerzon, Nancy

    2015-01-01

    Background: This research review provides an analysis of current research related to school and district data use, with a particular focus on identifying key characteristics of schools and districts with effective "data using cultures." The research review identifies and analyzes findings in five key areas of practice: communicating…

  5. Key Ethical Issues in Pediatric Research: Islamic Perspective, Iranian Experience

    PubMed Central

    Mobasher, Mina; Salari, Pooneh; Larijani, Bagher

    2012-01-01

    Objective The importance of pediatric research especially in the ethically proven trials resulted in considerable legislative attempts in association with compiling ethical guidelines. Because of children's vulnerability conducting pediatric research raises different ethical issues; the two most important of which are informed consent and risk-benefit assessment. Differences in religious and socio-cultural context limit implication of ethical standards. Methods At the aim of finding a solution we critically reviewed guidelines, and literatures as well as Islamic points in addition to comparing different viewpoints in application of ethical standards in pediatric research. Findings The literature review showed that pediatric research guidelines and authors’ viewpoints have the same basic ethical core, but there are some variations; depend on cultural, religious, and social differences. Furthermore, these standards have some limitations in defining informed consent according to child's age and capacity upon application. Conclusion In this regard Islamic approach and definition about growth development and puberty sheds light and clarifies a clearer and more rational address to the issue. PMID:23429172

  6. Researchers Find 8 Immune Genes in Aggressive Brain Cancer

    MedlinePlus

    ... 159031.html Researchers Find 8 Immune Genes in Aggressive Brain Cancer Discovery might eventually lead to better ... tissue samples from 170 people with a less aggressive type of brain tumor. This led to the ...

  7. Research Finds Link Between Statin Use and Progressive Muscle Disease

    MedlinePlus

    ... Research Finds Link Between Statin Use and Progressive Muscle Disease Each year, millions of Americans take statins, ... people these benefits come at a cost: widespread muscle pain that persists as long as the drugs ...

  8. Multiple Perpetrator Rape: Naming an Offence and Initial Research Findings

    ERIC Educational Resources Information Center

    Horvath, Miranda Angel Helena; Kelly, Liz

    2009-01-01

    Multiple perpetrator rape presents a significant problem nationally and internationally. However, previous research is limited and findings are often contradictory. The details of 101 rape allegations recorded in a six-month period in a large police force in England were analysed. Findings are presented about case classification, victim and…

  9. A System for Addressing Incidental Findings in Neuroimaging Research

    PubMed Central

    Cramer, Steven C.; Wu, Jennifer; Hanson, Joseph A.; Nouri, Sarvenaz; Karnani, Diraj; Chuang, Tony M.; Le, Vu

    2011-01-01

    When healthy subjects undergo brain imaging, incidental findings are not rare. The optimal response to such findings has been the focus of considerable discussion. The current report describes the operations and results of a system that provides review of incidental findings by an appropriate medical professional. A web-based system was created whereby investigators performing brain MRI scans on healthy subjects could refer images with suspected concerns to a board certified radiologist who had a Certificate of Added Qualification in Neuroradiology. The specific details of this system are described. Among 27 scans suspected by an investigator of having a significant finding, all but one were referred by a researcher with a PhD. The most common concerns described by these investigators were for the possible presence of a cyst or of enlarged ventricles. The most common findings reported by the radiologist were Virchow-Robin spaces and cysts. Findings were generally of low clinical significance, with 1 major exception. Identifying the optimal response to incidental findings in neuroimaging research remains a challenge. The current report describes a system for providing expert assistance and so addresses these issues in the setting of suspected incidental findings. To our knowledge the current system is the first to provide a specific means for evaluation of incidental findings in neuroimaging research. PMID:21224007

  10. IPCC Climate Change 2013: Mitigation of Climate Change - Key Findings and Lessons Learned

    NASA Astrophysics Data System (ADS)

    Sokona, Youba

    2014-05-01

    The Working Group III contribution to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change, Mitigation of Climate Change, examines the results of scientific research about mitigation, with special attention on how knowledge has evolved since the Fourth Assessment Report published in 2007. Throughout, the focus is on the implications of its findings for policy, without being prescriptive about the particular policies that governments and other important participants in the policy process should adopt. The report begins with a framing of important concepts and methods that help to contextualize the findings presented throughout the assessment. The valuation of risks and uncertainties, ethical concepts and the context of sustainable development and equity are among the guiding principles for the assessment of mitigation strategies. The report highlights past trends in stocks and flows of greenhouse gases and the factors that drive emissions at global, regional, and sectoral scales including economic growth, technology or population changes. It provides analyses of the technological, economic and institutional requirements of long-term mitigation scenarios and details on mitigation measures and policies that are applied in different economic sectors and human settlements. It then discusses interactions of mitigation policies and different policy instrument types at national, regional and global governance levels and between economic sectors, The Working Group III report comprises 16 chapters and in assembling this assessment authors were guided by the principles of the IPCC mandate: to be explicit about mitigation options, to be explicit about their costs and about their risks and opportunities vis-à-vis other development priorities, and to be explicit about the underlying criteria, concepts, and methods for evaluating alternative policies.

  11. Environmentally Mediated Risks for Psychopathology: Research Strategies and Findings

    ERIC Educational Resources Information Center

    Rutter, Michael

    2005-01-01

    Objective: To consider the research design requirements needed to provide a rigorous test of environmental mediation hypotheses and to summarize the main findings from research using such designs. Method: Selective review of empirical evidence dealing with psychopathology. Results: There is robust evidence of environmentally mediated risks for…

  12. Finding Fault? Exploring Legal Duties to Return Incidental Findings in Genomic Research.

    PubMed

    Pike, Elizabeth R; Rothenberg, Karen H; Berkman, Benjamin E

    2014-01-01

    The use of whole-genome sequencing in biomedical research is expected to produce dramatic advances in human health. The increasing use of this powerful, data-rich new technology in research, however, will inevitably give rise to incidental findings (IFs)-findings with individual health or reproductive significance that are beyond the aims of the particular research-and the related questions of whether and to what extent researchers have an ethical obligation to return IFs. Many have concluded that researchers have an ethical obligation to return some findings in some circumstances but have provided vague or context-dependent approaches to determining which IFs must be returned and when. As a result, researchers have started returning IFs inconsistently, giving rise to concerns about legal liability in circumstances in which notification could have potentially prevented injury. Although it is clear that ethical guidance should not be automatically codified as law and that crafting ethical obligations around legal duties can be inappropriate, the ethical debate should not proceed unaware of the potential legal ramifications of advancing and implementing an ethical obligation to return IFs. This Article assesses the legal claims that could be brought for a researcher's failure to return IFs. The potential for researchers to be held liable in tort is still uncertain and turns largely on a number of factors-including customary practice and guidance documents-that are still in flux. Unlike medical care, which has a well-defined duty into which evolving scientific knowledge about genetics and genomics can readily be incorporated, a researcher's duty to return IFs is less well defined, making it difficult to determine at the outset whether and when legal liability will attach. This Article advocates for a clearer, ethically sound standard of requiring that researchers disclose in the informed consent document which approach to offering IFs will be taken. This approach

  13. In Search of New Ideas, Research Findings, and Emerging Technologies? Here's Where To Find Them.

    ERIC Educational Resources Information Center

    Powell, Gary C.

    There are many avenues available to computer-assisted instruction (CAI) practitioners and developers in search of access to new ideas, research findings, and emerging technologies that will assist them in developing CAI products. Seven such avenues are described in detail: (1) graduate student interns, who bring unique insights, theory, and…

  14. Recruiting Underserved Mothers to Medical Research: Findings from North Carolina

    PubMed Central

    Spears, Chaya R.; Sandberg, Joanne C.; O’Neill, Jenna L.; Grzywacz, Joseph G.; Howard, Timothy D.; Feldman, Steven R.; Arcury, Thomas A.

    2014-01-01

    Representative samples are required for ethical, valid, and useful health research. Yet, recruiting participants, especially from historically underserved communities, can be challenging. This paper presents findings from in-depth interviews with 40 mothers about factors that might influence their willingness to participate or allow their children to participate in medical research. Saliency analysis organizes the findings. Frequent and important salient themes about research participation included concerns that it might cause participants harm, hope that participants might gain a health benefit, and recognition that time and transportation resources could limit participation. Ultimately, we propose that a theoretical model, such as the Theory of Planned Behavior (TPB), will facilitate more systematic evaluation of effective methods for recruitment and retention of participants in medical research. Future research should explore the utility of such a model for development of effective recruitment and retention strategies. PMID:24185171

  15. Genetically Informative Research on Adolescent Substance Use: Methods, Findings, and Challenges

    ERIC Educational Resources Information Center

    Lynskey, Michael T.; Agrawal, Arpana; Heath, Andrew C.

    2010-01-01

    Objective: To provide an overview of the genetic epidemiology of substance use and misuse in adolescents. Method: A selective review of genetically informative research strategies, their limitations, and key findings examining issues related to the heritability of substance use and substance use disorders in children and adolescents is presented.…

  16. Finding Fault? Exploring Legal Duties to Return Incidental Findings in Genomic Research

    PubMed Central

    Pike, Elizabeth R.; Rothenberg, Karen H.; Berkman, Benjamin E.

    2014-01-01

    The use of whole-genome sequencing in biomedical research is expected to produce dramatic advances in human health. The increasing use of this powerful, data-rich new technology in research, however, will inevitably give rise to incidental findings (IFs)—findings with individual health or reproductive significance that are beyond the aims of the particular research—and the related questions of whether and to what extent researchers have an ethical obligation to return IFs. Many have concluded that researchers have an ethical obligation to return some findings in some circumstances but have provided vague or context-dependent approaches to determining which IFs must be returned and when. As a result, researchers have started returning IFs inconsistently, giving rise to concerns about legal liability in circumstances in which notification could have potentially prevented injury. Although it is clear that ethical guidance should not be automatically codified as law and that crafting ethical obligations around legal duties can be inappropriate, the ethical debate should not proceed unaware of the potential legal ramifications of advancing and implementing an ethical obligation to return IFs. This Article assesses the legal claims that could be brought for a researcher’s failure to return IFs. The potential for researchers to be held liable in tort is still uncertain and turns largely on a number of factors—including customary practice and guidance documents—that are still in flux. Unlike medical care, which has a well-defined duty into which evolving scientific knowledge about genetics and genomics can readily be incorporated, a researcher’s duty to return IFs is less well defined, making it difficult to determine at the outset whether and when legal liability will attach. This Article advocates for a clearer, ethically sound standard of requiring that researchers disclose in the informed consent document which approach to offering IFs will be taken. This

  17. Monitoring the Future: National Results on Adolescent Drug Use. Overview of Key Findings, 2006

    ERIC Educational Resources Information Center

    Johnston, Lloyd D., O'Malley, Patrick M.; Bachman, Jerald G.; Schulenberg, John E.

    2007-01-01

    This report provides a summary of drug use trends from a survey of nearly 50,000 eighth-, tenth-, and twelfth- grade students nationwide. It also includes perceived risk, personal disapproval, and perceived availability of each drug by this group. A synopsis of the methods used in the study and an overview of the key results from the 2006 survey…

  18. Needles and Haystacks: Finding Funding for Medical Education Research.

    PubMed

    Gruppen, Larry D; Durning, Steven J

    2016-04-01

    Medical education research suffers from a significant and persistent lack of funding. Although adequate funding has been shown to improve the quality of research, there are a number of factors that continue to limit it. The competitive environment for medical education research funding makes it essential to understand strategies for improving the search for funding sources and the preparation of proposals. This article offers a number of resources, strategies, and suggestions for finding funding. Investigators must be able to frame their research in the context of significant issues and principles in education. They must set their proposed work in the context of prior work and demonstrate its potential for significant new contributions. Because there are few funding sources earmarked for medical education research, researchers much also be creative, flexible, and adaptive as they seek to present their ideas in ways that are appealing and relevant to the goals of funders. Above all, the search for funding requires persistence and perseverance. PMID:26556292

  19. Finding solid ground: law enforcement, key populations and their health and rights in South Africa

    PubMed Central

    Scheibe, Andrew; Howell, Simon; Müller, Alexandra; Katumba, Munyaradzi; Langen, Bram; Artz, Lillian; Marks, Monique

    2016-01-01

    Introduction Sex workers, people who use drugs, men who have sex with men, women who have sex with women and transgender people in South Africa frequently experience high levels of stigma, abuse and discrimination. Evidence suggests that such abuse is sometimes committed by police officers, meaning that those charged with protection are perpetrators. This reinforces cycles of violence, increases the risk of HIV infection, undermines HIV prevention and treatment interventions and violates the constitutional prescriptions that the police are mandated to protect. This paper explores how relationship building can create positive outcomes while taking into account the challenges associated with reforming police strategies in relation to key populations, and vice versa. Discussion We argue that relationships between law enforcement agencies and key populations need to be re-examined and reconstituted to enable appropriate responses and services. The antagonistic positioning, “othering” and blame assignment frequently seen in interactions between law enforcement officials and key populations can negatively influence both, albeit for different reasons. In addressing these concerns, we argue that mediation based on consensual dialogue is required, and can be harnessed through a process that highlights points of familiarity that are often shared, but not understood, by both parties. Rather than laying blame, we argue that substantive changes need to be owned and executed by all role-players, informed by a common language that is cognisant of differing perspectives. Conclusions Relational approaches can be used to identify programmes that align goals that are part of law enforcement, human rights and public health despite not always being seen as such. Law enforcement champions and representatives of key populations need to be identified and supported to promote interventions that are mutually reinforcing, and address perceived differences by highlighting commonality

  20. Relationships Always Matter: Findings from a Phenomenological Research Inquiry

    ERIC Educational Resources Information Center

    Giles, David L.

    2011-01-01

    This paper reports on findings from a hermeneutic phenomenological research inquiry which explored the nature of relational experiences in teacher education. Stories of the lived experience of relationships in an educational context were hermeneutically interpreted against the philosophical writings of Heidegger, Gadamer, Levinas, and Buber. The…

  1. Educational Financing in Developing Countries: Research Findings and Contemporary Issues.

    ERIC Educational Resources Information Center

    Schiefelbein, Ernesto

    This study focuses on contemporary issues of educational financing in developing countries and on available research findings as these relate, or can be related, to these issues. The first two chapters are analytical, examining common educational finance issues and testing the conventional wisdom of certain usual proposals. Chapter 1, "Issues in…

  2. How Useful are the Findings from the Research on Teaching?

    ERIC Educational Resources Information Center

    Stallings, Jane A.

    An overview is presented of research studies (carried out in the 1970s) dealing with the influence of time on student academic achievement. Discussions illuminate studies and findings about: (1) length of school day; (2) academic learning time; (3) achievement levels and academic time; (4) clarity of first day organization and planning; (5) time…

  3. Becoming a Scientist: Research Findings on STEM Students' Gains from Conducting Undergraduate Research

    NASA Astrophysics Data System (ADS)

    Hunter, A.; Laursen, S.; Thiry, H.; Seymour, E.

    2006-12-01

    Undergraduate research is widely believed to enhance STEM students' education and increase their persistence to graduate education and careers in the sciences. Yet until very recently, little evidence from research and evaluation studies was available to substantiate such claims and document what students gain from doing undergraduate research or how these gains come about. We have conducted a three-year qualitative research study of STEM students participating in UR at four liberal arts colleges with a strong tradition of faculty-led summer research apprenticeships. Benefits to students reported by both students and their faculty advisors are categorized into six main categories of gains in skills, knowledge, "thinking like a scientist," career preparation, career development, and personal and professional growth. Student and faculty observations are strongly corroborative, but also differ in interesting ways that reflect the distinct perspectives of each group: students are still in the midst of discovering their own career paths while faculty advisors have observed the later career development of their past research students. While not all students find UR to heighten their interest in graduate school, they do find it a powerful growth experience that clarifies their career ambitions by providing a "real world" experience of science. For students whose interest in science is reinforced, UR has a significant role in their professional socialization into the culture and norms of science, which we call "becoming a scientist," through interactions that draw them into the scientific community and experiences that deepen their understanding of the nature of research. Cumulatively, the qualitative data set of nearly 350 interviews offers a rich portrayal of the UR enterprise from a variety of perspectives. Longitudinal data enable us to track the influence of UR on students' career and education trajectories in the years after college, and comparative data from a group

  4. Roots and Research. Key Stage 3 English. Key Stage 3: National Strategy.

    ERIC Educational Resources Information Center

    Harrison, Colin

    In 1998, Roger Beard of the University of Leeds wrote an account of the research underpinning the emerging National Literacy Strategy (NLS). Since Beard published his review, there have been developments both in terms of age groups covered and within the field of literacy research. This document attempts a fresh review of the relationship between…

  5. A Survey of American Voter Attitudes Concerning Child Care Services: Highlights and Key Findings.

    ERIC Educational Resources Information Center

    Marttila & Kiley, Inc., Boston, MA.

    A national telephone survey of a representative sample of 901 voters was conducted to measure voter attitudes toward child care and, in particular, the Act for Better Child Care Services (ABC). The survey also explored attitudes toward parental leave. Findings indicated that: (1) a majority of Americans think of child care as an urgent need and…

  6. Monitoring the Future National Results on Adolescent Drug Use: Overview of Key Findings, 1999.

    ERIC Educational Resources Information Center

    Johnston, Lloyd D.; O'Malley, Patrick M.; Bachman, Jerald G.

    This booklet presents an overview of the findings pertaining to eighth, tenth, and twelfth grade students from the 1999 Monitoring the Future Study. This overview focuses on recent trends in the use of various licit and illicit drugs. It also examines trends in the levels of perceived risk and personal disapproval associated with each drug, which…

  7. Time for Action! ICT Integration in Formal Education: Key Findings from a Region-Wide Follow-Up Monitor

    ERIC Educational Resources Information Center

    Goeman, Katie; Elen, Jan; Pynoo, Bram; van Braak, Johan

    2015-01-01

    This paper is a report on the key findings of a region-wide monitoring study conducted in Dutch-speaking schools in Belgium. First, we elaborate on the building blocks of the instrument, which has been updated and improved since its first deployment in 2007. In particular we focus on the core indicators, along with the multi-actor approach, the…

  8. 40 CFR 63.2831 - Where can I find definitions of key words used in this subpart?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true Where can I find definitions of key words used in this subpart? 63.2831 Section 63.2831 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission...

  9. 40 CFR 63.2831 - Where can I find definitions of key words used in this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Where can I find definitions of key words used in this subpart? 63.2831 Section 63.2831 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission...

  10. Reflections of Girls in the Media: A Two-Part Study on Gender and Media. Summary of Key Findings.

    ERIC Educational Resources Information Center

    1997

    This pamphlet summarizes the key findings of a two-part study that investigated the messages that young women (age 10 to 17) get from the media. A content analysis examined messages to girls across a range of media most heavily used by adolescent girls: television, movies, magazines, music videos, television commercials, and magazine…

  11. Who are the key players in a new translational research network?

    PubMed Central

    2013-01-01

    Background Professional networks are used increasingly in health care to bring together members from different sites and professions to work collaboratively. Key players within these networks are known to affect network function through their central or brokerage position and are therefore of interest to those who seek to optimise network efficiency. However, their identity may not be apparent. This study using social network analysis to ask: (1) Who are the key players of a new translational research network (TRN)? (2) Do they have characteristics in common? (3) Are they recognisable as powerful, influential or well connected individuals? Methods TRN members were asked to complete an on-line, whole network survey which collected demographic information expected to be associated with key player roles, and social network questions about collaboration in current TRN projects. Three questions asked who they perceived as powerful, influential and well connected. Indegree and betweenness centrality values were used to determine key player status in the actual and perceived networks and tested for association with demographic and descriptive variables using chi square analyses. Results Response rate for the online survey was 76.4% (52/68). The TRN director and manager were identified as key players along with six other members. Only two of nine variables were associated with actual key player status; none with perceived. The main finding was the mismatch between actual and perceived brokers. Members correctly identified two of the three central actors (the two mandated key roles director and manager) but there were only three correctly identified actual brokers among the 19 perceived brokers. Possible reasons for the mismatch include overlapping structures and weak knowledge of members. Conclusions The importance of correctly identifying these key players is discussed in terms of network interventions to improve efficiency. PMID:23987790

  12. Effective methods for disseminating research findings to nurses in practice.

    PubMed

    Cronenwett, L R

    1995-09-01

    Professionals in all disciplines are challenged by the proliferation of new knowledge. Nurses, too, must find cost-effective ways of ensuring that their patients are benefiting from the most current knowledge about health and illness. The methods of research dissemination to clinicians described in this article are presumed to be effective because of anecdotal reports, conference evaluations, or clinician surveys. The profession needs more sophisticated evaluations of the effectiveness of various dissemination methods. In the meantime, whether you are a researcher, an administrator, an educator, or a clinician, you have a role to play in improving research dissemination. Implement just one strategy from this article and evaluate the results. Each contribution moves nursing toward research-based practice. PMID:7567569

  13. Key components of anaphylaxis management plans: consensus findings from a national electronic Delphi study

    PubMed Central

    Worth, Allison; Nurmatov, Ulugbek; Sheikh, Aziz

    2010-01-01

    Objectives There is no international consensus on the components of anaphylaxis management plans and responsibility for their design and delivery is contested. We set out to establish consensus among relevant specialist and generalist clinicians on this issue to inform future randomized controlled trials. Design A two-round electronic Delphi study completed by a 25-person, multidisciplinary expert panel. Participants scored the importance of a range of statements on anaphylaxis management, identified from a systematic review of the literature, on a five-point scale ranging from ‘very important’ to ‘irrelevant’. Consensus was defined a priori as being achieved if 80% or more of panel members rated a statement as ‘important’ or ‘very important’ after Round 2. Setting Primary and secondary care and academic settings in the UK and Ireland. Participants Twenty-five medical, nursing and allied health professionals. Main outcome measures Consensus on the key components of anaphylaxis management plans. Results The response rate was 84% (n = 21) for Round 1 and 96% (n = 24) for Round 2. The key components of emergency care on which consensus was achieved included: awareness of trigger factors (100%); recognition and emergency management of reactions of different severity (100%); and clear information on adrenaline (epinephrine) use (100%). Consensus on longer-term management issues included: clear written guidelines on anaphylaxis management (96%); annual review of plans (87%); and plans that were tailored to individual needs (82%). Conclusions This national consensus-building exercise generated widespread agreement that emergency plans need to be simple, clear and generic, making them easy to implement in a crisis. In contrast, long-term plans need to be negotiated between patient/carers and professionals, and tailored to individual needs. The effectiveness of this expert-agreed long-term plan now needs to be evaluated rigorously. PMID:21103134

  14. Investigating Ideomotor Cognition with Motorvisual Priming Paradigms: Key Findings, Methodological Challenges, and Future Directions

    PubMed Central

    Thomaschke, Roland

    2012-01-01

    Ideomotor theory claims that perceptual representations of action-effects are functionally involved in the planning of actions. Strong evidence for this claim comes from a phenomenon called motorvisual priming. Motorvisual priming refers to the finding that action planning directly affects perception, and that the effects are selective for stimuli that share features with the planned action. Motorvisual priming studies have provided detailed insights into the processing of perceptual representations in action planning. One important finding is that such representations in action planning have a categorical format, whereas metric representations are not anticipated in planning. Further essential findings regard the processing mechanisms and the time course of ideomotor cognition. Perceptual representations of action-effects are first activated by action planning and then bound into a compound representation of the action plan. This compound representation is stabilized throughout the course of the action by the shielding of all involved representations from other cognitive processes. Despite a rapid growth in the number of motorvisual priming studies in the current literature, there are still many aspects of ideomotor cognition which have not yet been investigated. These aspects include the scope of ideomotor processing with regard to action types and stimulus types, as well as the exact nature of the binding and shielding mechanisms involved. PMID:23189067

  15. Recreation ecology research findings: Implications for wilderness and park managers

    USGS Publications Warehouse

    Marion, J.L.

    1998-01-01

    Recreationists unintentionally trample vegetation, erode soil, and disturb wildlife. Such human-related impacts present a dilemma for managers charged with the dual objectives of providing recreational opportunities and preserving natural environments. This paper presents some of the principal findings and management implications from research on visitor impacts to protected areas, termed recreation ecology research. This field of study seeks to identify the type and extent of resource impacts and to evaluate relationships between use-related, environmental, and managerial factors. The capabilities and managerial utility of recreation impact monitoring are also described.

  16. Transfer Velocity Project: Key Findings on Student Transfer in California Community Colleges

    ERIC Educational Resources Information Center

    Research and Planning Group for California Community Colleges (RP Group), 2010

    2010-01-01

    Which factors promote student transfer from California Community Colleges (CCC) to baccalaureate-granting institutions? How do community college practices support this transition? Which student behaviors and characteristics particularly facilitate their movement to four-year colleges and universities? The Research and Planning Group for California…

  17. Supporting Primary and Secondary Beginning Teachers Online: Key Findings of the Education Alumni Support Project

    ERIC Educational Resources Information Center

    Maxwell, T. W.; Harrington, I.; Smith, H. J.

    2010-01-01

    During 2005, the Education Alumni Support Project (EdASP) (Maxwell, Smith, Baxter, Boyd, Harrington, Jenkins, Sargeant & Tamatea 2006) provided online support for University of New England (UNE) graduand, and later, graduate, teachers as they commenced their careers. The project was based on research which reported that many beginning teachers did…

  18. Key Lessons about Induction for Policy Makers and Researchers

    ERIC Educational Resources Information Center

    Wayne, Andrew J.

    2012-01-01

    The purpose of this chapter is to digest the core chapters of this volume, which draws together some of the most sophisticated thinking on new teacher induction from the last decade. This chapter attends to five key understandings about induction programs, including their context, design, implementation, and outcomes. These understandings emerge…

  19. Key findings of the US Cystic Fibrosis Foundation's clinical practice benchmarking project.

    PubMed

    Boyle, Michael P; Sabadosa, Kathryn A; Quinton, Hebe B; Marshall, Bruce C; Schechter, Michael S

    2014-04-01

    Benchmarking is the process of using outcome data to identify high-performing centres and determine practices associated with their outstanding performance. The US Cystic Fibrosis Foundation (CFF) Patient Registry contains centre-specific outcomes data for all CFF-certified paediatric and adult cystic fibrosis (CF) care programmes in the USA. The CFF benchmarking project analysed these registry data, adjusting for differences in patient case mix known to influence outcomes, and identified the top-performing US paediatric and adult CF care programmes for pulmonary and nutritional outcomes. Separate multidisciplinary paediatric and adult benchmarking teams each visited 10 CF care programmes, five in the top quintile for pulmonary outcomes and five in the top quintile for nutritional outcomes. Key practice patterns and approaches present in both paediatric and adult programmes with outstanding clinical outcomes were identified and could be summarised as systems, attitudes, practices, patient/family empowerment and projects. These included: (1) the presence of strong leadership and a well-functioning care team working with a systematic approach to providing consistent care; (2) high expectations for outcomes among providers and families; (3) early and aggressive management of clinical declines, avoiding reliance on 'rescues'; and (4) patients/families that were engaged, empowered and well informed on disease management and its rationale. In summary, assessment of practice patterns at CF care centres with top-quintile pulmonary and nutritional outcomes provides insight into characteristic practices that may aid in optimising patient outcomes. PMID:24608546

  20. Efficient hit-finding approaches for histone methyltransferases: the key parameters.

    PubMed

    Ahrens, Thomas; Bergner, Andreas; Sheppard, David; Hafenbradl, Doris

    2012-01-01

    For many novel epigenetics targets the chemical ligand space and structural information were limited until recently and are still largely unknown for some targets. Hit-finding campaigns are therefore dependent on large and chemically diverse libraries. In the specific case of the histone methyltransferase G9a, the authors have been able to apply an efficient process of intelligent selection of compounds for primary screening, rather than screening the full diverse deck of 900 000 compounds to identify hit compounds. A number of different virtual screening methods have been applied for the compound selection, and the results have been analyzed in the context of their individual success rates. For the primary screening of 2112 compounds, a FlashPlate assay format and full-length histone H3.1 substrate were employed. Validation of hit compounds was performed using the orthogonal fluorescence lifetime technology. Rated by purity and IC(50) value, 18 compounds (0.9% of compound screening deck) were finally considered validated primary G9a hits. The hit-finding approach has led to novel chemotypes being identified, which can facilitate hit-to-lead projects. This study demonstrates the power of virtual screening technologies for novel, therapeutically relevant epigenetics protein targets. PMID:21990582

  1. Research findings can change attitudes about corporal punishment.

    PubMed

    Holden, George W; Brown, Alan S; Baldwin, Austin S; Croft Caderao, Kathryn

    2014-05-01

    Positive attitudes toward the use of corporal punishment (CP) predict subsequent spanking behavior. Given that CP has frequently been associated with behavior problems in children and child maltreatment, this prevention work was designed to test whether adults' attitudes could be changed by informing participants about the research findings on problematic behaviors associated with CP. Two random assignment studies are reported. In Study 1, we tested whether an active reading condition would result in more attitude change than a passive condition. With a sample of 118 non-parent adults, we found that after reading very brief research summaries on the problems associated with CP, there was a significant decrease in favorable attitudes toward CP. Contrary to expectations, the magnitude of the change was comparable for active and passive processing conditions. In Study 2, we extended our approach to a sample of 520 parents and included a control group. A significant decrease in positive attitudes toward spanking was observed in the intervention group, but no change for the control group. Parents who were unaware of the research showed more change after reading the summaries. Thus, these studies demonstrate that a brief and cost-effective approach to raise awareness of research findings can reduce positive attitudes toward CP. Implications for prevention and intervention are discussed. PMID:24246718

  2. A snapshot of U.S. physicians: key findings from the 2008 Health Tracking Physician Survey.

    PubMed

    Boukus, Ellyn; Cassil, Alwyn; O'Malley, Ann S

    2009-09-01

    This Data Bulletin presents findings from the Center for Studying Health System Change (HSC) 2008 Health Tracking Physician Survey, a nationally representative mail survey of U.S. physicians providing at least 20 hours per week of direct patient care. The sample of physicians was drawn from the American Medical Association master file and included active, nonfederal, office- and hospital-based physicians. Residents and fellows were excluded, as well as radiologists, anesthesiologists and pathologists. The survey includes responses from more than 4,700 physicians, and the response rate was 62 percent. Estimates from this survey should not be compared to estimates from HSC's previous Community Tracking Study (CTS) Physician Surveys because of changes in the survey administration mode from telephone to mail, question wording, skip patterns, sample structure and population represented. More detailed information on survey content and methodology can be found at www.hschange.org. PMID:19768851

  3. Research on Key Technology and Applications for Internet of Things

    NASA Astrophysics Data System (ADS)

    Chen, Xian-Yi; Jin, Zhi-Gang

    The Internet of Things (IOT) has been paid more and more attention by the academe, industry, and government all over the world. The concept of IOT and the architecture of IOT are discussed. The key technologies of IOT, including Radio Frequency Identification technology, Electronic Product Code technology, and ZigBee technology are analyzed. The framework of digital agriculture application based on IOT is proposed.

  4. Barriers in implementing research findings in cancer care: the Greek registered nurses perceptions.

    PubMed

    Patiraki, Elisabeth; Karlou, Chrysoula; Papadopoulou, Despina; Spyridou, Ageliki; Kouloukoura, Chrysoula; Bare, Elpida; Merkouris, Anastasios

    2004-09-01

    This study explored Greek nurses' perceptions of the barriers to research utilization faced in every day practice. The barriers between nurses working in cancer and general hospitals, as well as between those employed at central and provincial hospitals were compared. The study used a cross-sectional design and data were collected using the "Barriers Scale" (Funk et al., 1991a, Applied Nursing Research, 4, 39-45). A convenience sample of 301 nurses was randomly selected from 12 hospitals in Greece. The two key barriers identified were related to the 'availability of research findings'. English language was perceived to range between moderate and major barrier for the vast majority of participants (n = 231, 78%). Nurses surveyed indicated the presentation of research findings as the greatest barrier while the characteristics of nurses themselves were perceived as the least important one. No significant differences were found between types of hospitals (cancer/general) and geographical areas (central/provincial). Some differences, however, were observed in relation to specific items of the scale such as feeling isolated from 'research-knowledgeable' colleagues and having insufficient time to implement new ideas. The observations reported here appear to agree with the findings in mainstream literature. The results suggest that more emphasis should be given in research methodology, statistics and critical appraisal skills at all levels of nursing education, and that efforts should be made towards increasing research availability and creating supportive environments for implementation of research findings. PMID:15304232

  5. Hurricane Sandy: An Educational Bibliography of Key Research Studies

    ERIC Educational Resources Information Center

    Piotrowski, Chris

    2013-01-01

    There, undoubtedly, will be a flurry of research activity in the "Superstorm" Sandy impact area on a myriad of disaster-related topics, across academic disciplines. The purpose of this study was to review the disaster research related specifically to hurricanes in the educational and social sciences that would best serve as a compendium…

  6. Specific Shrinkage of Carotid Forks in Moyamoya Disease: A Novel Key Finding for Diagnosis

    PubMed Central

    KURODA, Satoshi; KASHIWAZAKI, Daina; AKIOKA, Naoki; KOH, Masaki; HORI, Emiko; NISHIKATA, Manabu; UMEMURA, Kimiko; HORIE, Yukio; NOGUCHI, Kyo; KUWAYAMA, Naoya

    2015-01-01

    This study was aimed to analyze the outer diameter of the involved arteries in moyamoya disease, using three-dimensional (3D) constructive interference in steady state (CISS) and direct surgical inspection. Radiological evaluation was performed in 64 patients with moyamoya disease. As the controls, six patients with severe middle cerebral artery (MCA) stenosis and 17 healthy subjects were also recruited. On 3D-CISS, the outer diameter was quantified in the supraclinoid portion of internal carotid artery (C1), the horizontal portions of MCA (M1) and anterior cerebral artery (A1), and basilar artery. The involved carotid fork was directly observed during surgery in another series of three adult patients with moyamoya disease. In 53 adult patients with moyamoya disease, the outer diameters of C1, M1, and A1 segments were 2.3 ± 0.7 mm, 1.3 ± 0.5 mm, and 1.0 ± 0.4 mm in the involved side (n = 91), being significantly smaller than the control (n = 17), severe M1 stenosis (n = 6), and non-involved side in moyamoya disease (n = 15, P < 0.01). There were significant correlations between Suzuki’s angiographical stage and the outer diameters of C1, M1, and A1 (P < 0.001). The laterality ratio of C1 and M1 was significantly smaller in unilateral moyamoya disease (n = 20) than the controls and severe MCA stenosis (P < 0.01). Direct observations revealed a marked decrease in the outer diameter of the carotid fork (n = 3). These findings strongly suggest specific shrinkage of the involved arteries in moyamoya disease, which may provide essential information to distinguish moyamoya disease from other intracranial arterial stenosis and shed light on the etiology and novel diagnosis cue of moyamoya disease. PMID:26369872

  7. Tectonic history of Sweetgrass Arch, Montana and Alberta-key to finding new hydrocarbons

    SciTech Connect

    Shepard, W. Shepard, B.

    1985-05-01

    The Sweetgrass arch of northwestern Montana and southern Alberta is a major ancient structural feature. Initial anticlinal emplacement occurred during the early Paleozoic and was parallel with the cratonic margin. Strong uplift followed by peneplanation occurred during the Late Jurassic and basal Cretaceous during the westward drifting of the North American plate following the breakup of Pangea. During Cretaceous and early Tertiary times, the Sweetgrass arch was quiescent, but was rejuvenated in mid to late Tertiary, upwarped by a basement flexure to its present structural configuration: a 200 mi (322 km) long, north-plunging anticline showing 10,000 ft (350 m) of structural relief. Midway down its plunge, the anticline is offset 30 mi (48 km) by a right-lateral transcurrent fault. During Late Cretaceous and early Tertiary, plutonic uplifts were emplaced on the east flank, forming traps for oil then migrating updip from the Williston and Alberta basins. Oil and gas accumulated in Mississippian, Jurassic, and basal Cretaceous reservoirs in structural and stratigraphic traps around these plutonic uplifts. Subsequent late Tertiary doming of the Sweetgrass arch tilted the earlier structural traps and drained them, resulting in remigration of much of the oil and gas to the crest of the arch. The tilting failed to destroy many of the stratigraphic traps. As a result, down the flanks of the Sweetgrass arch are many frozen stratigraphic traps including Cut Bank field, the largest single-pay stratigraphic trap in the north Rockies. On the crest are large structure accumulations of remigrated oil at Kevin Sunburst and Pondera. Evidence of remigration is recorded by live oil show tracks in the reservoirs and remnant gas caps throughout the area of earlier accumulations. A potential exists for finding new frozen traps on the flanks and remigrated oil accumulations on or near the crest of the Sweetgrass arch.

  8. Risk factors for conduct disorder and delinquency: key findings from longitudinal studies.

    PubMed

    Murray, Joseph; Farrington, David P

    2010-10-01

    Conduct disorder (CD) and delinquency are behavioural problems involving violation of major rules, societal norms, and laws. The prevalence of CD and delinquency peaks in mid-to-late adolescence. Both show considerable continuity over time. The most important studies of CD and delinquency have prospective longitudinal designs, large community samples, repeated personal interviews, measures of many possible risk factors, and both self-reports and official measures of antisocial behaviour. The most important risk factors that predict CD and delinquency include impulsiveness, low IQ and low school achievement, poor parental supervision, punitive or erratic parental discipline, cold parental attitude, child physical abuse, parental conflict, disrupted families, antisocial parents, large family size, low family income, antisocial peers, high delinquency rate schools, and high crime neighbourhoods. However, for many risk factors, it is not known whether they have causal effects. Future research should examine changes in risk factors and changes in CD and delinquency to identify the risk factors that are causes and those that are merely markers of other risk mechanisms. PMID:20964942

  9. Dissemination as Dialogue: Building Trust and Sharing Research Findings Through Community Engagement.

    PubMed

    McDavitt, Bryce; Bogart, Laura M; Mutchler, Matt G; Wagner, Glenn J; Green, Harold D; Lawrence, Sean Jamar; Mutepfa, Kieta D; Nogg, Kelsey A

    2016-01-01

    A fundamental feature of community-based participatory research (CBPR) is sharing findings with community members and engaging community partners in the dissemination process. To be truly collaborative, dissemination should involve community members in a two-way dialogue about new research findings. Yet little literature describes how to engage communities in dialogue about research findings, especially with historically marginalized communities where mistrust of researchers may exist because of past or present social injustices. Through a series of interactive community presentations on findings from a longitudinal study, we developed a process for community dissemination that involved several overlapping phases: planning, outreach, content development, interactive presentations, and follow-up. Through this process, we built on existing and new community relationships. Following each interactive presentation, the research team debriefed and reviewed notes to identify lessons learned from the process. Key themes included the importance of creating a flexible dissemination plan, tailoring presentations to each community group, establishing a point person to serve as a community liaison, and continuing dialogue with community members after the presentations. Core strategies for developing trust during dissemination included engaging community members at every step, reserving ample time for discussion during presentations, building rapport by sharing personal experiences, being receptive to and learning from criticism, and implementing input from community members. This process led to a deeper understanding of research findings and ensured that results reached community members who were invested in them. PMID:26986541

  10. Dissemination as Dialogue: Building Trust and Sharing Research Findings Through Community Engagement

    PubMed Central

    Bogart, Laura M.; Mutchler, Matt G.; Wagner, Glenn J.; Green, Harold D.; Lawrence, Sean Jamar; Mutepfa, Kieta D.; Nogg, Kelsey A.

    2016-01-01

    A fundamental feature of community-based participatory research (CBPR) is sharing findings with community members and engaging community partners in the dissemination process. To be truly collaborative, dissemination should involve community members in a two-way dialogue about new research findings. Yet little literature describes how to engage communities in dialogue about research findings, especially with historically marginalized communities where mistrust of researchers may exist because of past or present social injustices. Through a series of interactive community presentations on findings from a longitudinal study, we developed a process for community dissemination that involved several overlapping phases: planning, outreach, content development, interactive presentations, and follow-up. Through this process, we built on existing and new community relationships. Following each interactive presentation, the research team debriefed and reviewed notes to identify lessons learned from the process. Key themes included the importance of creating a flexible dissemination plan, tailoring presentations to each community group, establishing a point person to serve as a community liaison, and continuing dialogue with community members after the presentations. Core strategies for developing trust during dissemination included engaging community members at every step, reserving ample time for discussion during presentations, building rapport by sharing personal experiences, being receptive to and learning from criticism, and implementing input from community members. This process led to a deeper understanding of research findings and ensured that results reached community members who were invested in them. PMID:26986541

  11. Authentic Research Immersion Experiences: the Key to Enduring Understandings

    NASA Astrophysics Data System (ADS)

    Klug, S. L.

    2007-12-01

    Do authentic research experiences have a role in today's classrooms? Where do they fit into the constrained curriculum units and high-stakes testing regimen that define a teacher's world? It is possible, even in today's somewhat narrow teaching environment, to integrate authentic research into the classroom and evolve away from the worksheets and lessons that simply "teach to the test"? Authentic research immersion experiences must be carefully packaged the for classroom use with clear alignment to standards and a learning curve that is not too daunting. By helping teachers to see the value in replacing curricular units with authentic research experiences and designing the research program to fit within a teacher's needs, the rate of successful adoption of the research program becomes much higher. As a result, not only do their students reap the educational rewards of becoming active research participants in the process of science and learn it from the inside out, but the opportunity for the teachers to grow professionally in content and science process knowledge is also an additional benefit. NASA has had and continues to have a significant role in providing these data and mission- related immersion experiences for elementary classrooms through graduate school students.

  12. Alcohol Consumption among Youth: Current Trends and Research Findings. Prevention Research Update. No. 12.

    ERIC Educational Resources Information Center

    Austin, Gregory; Roizen, Ron

    This update offers current knowledge about the scope and nature of adolescent drinking. Its goal is to bridge the communications gap between the researcher, the practitioner, and the general population by disseminating research findings in an accessible manner and by providing an introductory review of the significance of these findings. Abstracts…

  13. Educating to Tolerance: Effects of Communicating Social Psychology Research Findings.

    PubMed

    La Barbera, Francesco

    2015-08-01

    The effect of communicating social psychology research findings on ingroup bias in a classroom setting has been investigated. Two hundred and twenty one high school students either read or did not read a brief report about three classical social psychological studies, then completed evaluation scales for the ingroup and the outgroup. Participants' motivation was manipulated, and the messages were different as regards the congruency between the content and participants' actual intergroup experience. Results showed that communication exerted a significant effect in reducing ingroup bias for participants in the high motivation/high congruency condition, that is, the communication effect was moderated by the individual's level of motivation and the content of the arguments proposed in the report. Practical implications of results for education work and stereotype change, limitations of the study, as well as possible directions for future research are discussed. PMID:27247671

  14. Educating to Tolerance: Effects of Communicating Social Psychology Research Findings

    PubMed Central

    La Barbera, Francesco

    2015-01-01

    The effect of communicating social psychology research findings on ingroup bias in a classroom setting has been investigated. Two hundred and twenty one high school students either read or did not read a brief report about three classical social psychological studies, then completed evaluation scales for the ingroup and the outgroup. Participants’ motivation was manipulated, and the messages were different as regards the congruency between the content and participants’ actual intergroup experience. Results showed that communication exerted a significant effect in reducing ingroup bias for participants in the high motivation/high congruency condition, that is, the communication effect was moderated by the individual’s level of motivation and the content of the arguments proposed in the report. Practical implications of results for education work and stereotype change, limitations of the study, as well as possible directions for future research are discussed. PMID:27247671

  15. Writing implementation research grant proposals: ten key ingredients

    PubMed Central

    2012-01-01

    Background All investigators seeking funding to conduct implementation research face the challenges of preparing a high-quality proposal and demonstrating their capacity to conduct the proposed study. Applicants need to demonstrate the progressive nature of their research agenda and their ability to build cumulatively upon the literature and their own preliminary studies. Because implementation science is an emerging field involving complex and multilevel processes, many investigators may not feel equipped to write competitive proposals, and this concern is pronounced among early stage implementation researchers. Discussion This article addresses the challenges of preparing grant applications that succeed in the emerging field of dissemination and implementation. We summarize ten ingredients that are important in implementation research grants. For each, we provide examples of how preliminary data, background literature, and narrative detail in the application can strengthen the application. Summary Every investigator struggles with the challenge of fitting into a page-limited application the research background, methodological detail, and information that can convey the project’s feasibility and likelihood of success. While no application can include a high level of detail about every ingredient, addressing the ten ingredients summarized in this article can help assure reviewers of the significance, feasibility, and impact of the proposed research. PMID:23062065

  16. Key challenges in future Li-battery research.

    PubMed

    Tarascon, J-M

    2010-07-28

    Batteries are a major technological challenge in this new century as they are a key method to make more efficient use of energy. Although today's Li-ion technology has conquered the portable electronic markets and is still improving, it falls short of meeting the demands dictated by the powering of both hybrid electric vehicles and electric vehicles or by the storage of renewable energies (wind, solar). There is room for optimism as long as we pursue paradigm shifts while keeping in mind the concept of materials sustainability. Some of these concepts, relying on new ways to prepare electrode materials via eco-efficient processes, on the use of organic rather than inorganic materials or new chemistries will be discussed. Achieving these concepts will require the inputs of multiple disciplines. PMID:20566508

  17. Managing incidental findings and research results in genomic research involving biobanks and archived data sets.

    PubMed

    Wolf, Susan M; Crock, Brittney N; Van Ness, Brian; Lawrenz, Frances; Kahn, Jeffrey P; Beskow, Laura M; Cho, Mildred K; Christman, Michael F; Green, Robert C; Hall, Ralph; Illes, Judy; Keane, Moira; Knoppers, Bartha M; Koenig, Barbara A; Kohane, Isaac S; Leroy, Bonnie; Maschke, Karen J; McGeveran, William; Ossorio, Pilar; Parker, Lisa S; Petersen, Gloria M; Richardson, Henry S; Scott, Joan A; Terry, Sharon F; Wilfond, Benjamin S; Wolf, Wendy A

    2012-04-01

    Biobanks and archived data sets collecting samples and data have become crucial engines of genetic and genomic research. Unresolved, however, is what responsibilities biobanks should shoulder to manage incidental findings and individual research results of potential health, reproductive, or personal importance to individual contributors (using "biobank" here to refer both to collections of samples and collections of data). This article reports recommendations from a 2-year project funded by the National Institutes of Health. We analyze the responsibilities involved in managing the return of incidental findings and individual research results in a biobank research system (primary research or collection sites, the biobank itself, and secondary research sites). We suggest that biobanks shoulder significant responsibility for seeing that the biobank research system addresses the return question explicitly. When reidentification of individual contributors is possible, the biobank should work to enable the biobank research system to discharge four core responsibilities to (1) clarify the criteria for evaluating findings and the roster of returnable findings, (2) analyze a particular finding in relation to this, (3) reidentify the individual contributor, and (4) recontact the contributor to offer the finding. We suggest that findings that are analytically valid, reveal an established and substantial risk of a serious health condition, and are clinically actionable should generally be offered to consenting contributors. This article specifies 10 concrete recommendations, addressing new biobanks as well as those already in existence. PMID:22436882

  18. Researching Treaty Information: An Annotated Guide to Key Reference Sources.

    ERIC Educational Resources Information Center

    Miller, Gordon W.

    1985-01-01

    Designed for use with both individual researchers and library instruction classes, this 68-item selective annotated guide lists sources for guides and bibliographies; treatises, digests, citators; treaty texts and their indexes; dictionaries; atlases; style manuals; indexes and abstracts; journals; online databases; and abbreviations. Eleven…

  19. Student as Communication Skills Trainer: From Research to "Concept Keys"

    ERIC Educational Resources Information Center

    Bodie, Graham D.

    2008-01-01

    Although textbooks are filled with practical communication advice, many students overlook the importance of basing practical advice about communication on quality research. This oversight is important for two reasons. First, given the explosion of self-help remedies focused on communication, students should learn to distinguish between…

  20. Male mental health problems, psychopathy, and personality traits: key findings from the first 14 years of the Pittsburgh Youth Study.

    PubMed

    Loeber, R; Farrington, D P; Stouthamer-Loeber, M; Moffitt, T E; Caspi, A; Lynam, D

    2001-12-01

    This paper reviews key findings on juvenile mental health problems in boys, psychopathy, and personality traits, obtained in the first 14 years of studies using data from the Pittsburgh Youth Study. This is a study of 3 samples, each of about 500 boys initially randomly drawn from boys in the 1st, 4th, and 7th grades of public schools in Pittsburgh. The boys have been followed regularly, initially each half year, and later at yearly intervals. Currently, the oldest boys are about 25 years old, whereas the youngest boys are about 19. Findings are presented on the prevalence and interrelation of disruptive behaviors, ADHD, and depressed mood. Results concerning risk factors for these outcomes are reviewed. Psychological factors such as psychopathy, impulsivity, and personality are described. The paper closes with findings on service delivery of boys with mental health problems. PMID:11837460

  1. Incidental Findings in Imaging Research: Evaluating Incidence, Benefit and Burden

    PubMed Central

    Orme, Nicholas M.; Fletcher, Joel G.; Siddiki, Hassan A.; Harmsen, W. Scott; O’Byrne, Megan M.; Port, John D.; Tremaine, William J.; Pitot, Henry C.; McFarland, Beth; Robinson, Marguerite E.; Koenig, Barabara A.; King, Bernard F.; Wolf, Susan M.

    2013-01-01

    Context Little information exists concerning the frequency of clinically significant incidental findings (IFs) identified in the course of imaging research across a broad spectrum of imaging modalities and body regions. Objective To estimate the frequency with which research imaging IFs generate further clinical action, and the medical benefit/burden of identifying these IFs. Design, Setting, and Participants Retrospective review of subjects undergoing a research imaging exam that was interpreted by a radiologist for IFs in the first quarter of 2004, with 3-year clinical follow-up. An expert panel reviewed IFs generating clinical action to determine medical benefit/burden based on predefined criteria. Main Outcome Measures Frequency of (1) IFs that generated further clinical action by modality, body part, age, gender, and (2) IFs resulting in clear medical benefit or burden. Results 1376 patients underwent 1426 research imaging studies. 40% (567/1426) of exams had at least one IF (1055 total). Risk of an IF increased significantly by age (OR=1.5; [1.4–1.7=95% C.I.] per decade increase). Abdominopelvic CT generated more IFs than other exams (OR=18.9 compared with ultrasound; 9.2% with subsequent clinical action), with CT Thorax and MR brain next (OR=11.9 and 5.9; 2.8% and 2.2% with action, respectively). Overall 6.2% of exams (35/567) with an IF generated clinical action, resulting in clear medical benefit in 1.1% (6/567) and clear medical burden in 0.5% (3/567). In most instances, medical benefit/burden was unclear (4.6%; 26/567). Conclusions The frequency of IFs in imaging research exams varies significantly by imaging modality, body region and age. Research imaging studies at high risk for generating IFs can be identified. Routine evaluation of research images by radiologists may result in identification of IFs in a substantial number of cases and subsequent clinical action to address them in much smaller number. Such clinical action can result in medical

  2. Research on key technologies of LADAR echo signal simulator

    NASA Astrophysics Data System (ADS)

    Xu, Rui; Shi, Rui; Ye, Jiansen; Wang, Xin; Li, Zhuo

    2015-10-01

    LADAR echo signal simulator is one of the most significant components of hardware-in-the-loop (HWIL) simulation systems for LADAR, which is designed to simulate the LADAR return signal in laboratory conditions. The device can provide the laser echo signal of target and background for imaging LADAR systems to test whether it is of good performance. Some key technologies are investigated in this paper. Firstly, the 3D model of typical target is built, and transformed to the data of the target echo signal based on ranging equation and targets reflection characteristics. Then, system model and time series model of LADAR echo signal simulator are established. Some influential factors which could induce fixed delay error and random delay error on the simulated return signals are analyzed. In the simulation system, the signal propagating delay of circuits and the response time of pulsed lasers are belong to fixed delay error. The counting error of digital delay generator, the jitter of system clock and the desynchronized between trigger signal and clock signal are a part of random delay error. Furthermore, these system insertion delays are analyzed quantitatively, and the noisy data are obtained. The target echo signals are got by superimposing of the noisy data and the pure target echo signal. In order to overcome these disadvantageous factors, a method of adjusting the timing diagram of the simulation system is proposed. Finally, the simulated echo signals are processed by using a detection algorithm to complete the 3D model reconstruction of object. The simulation results reveal that the range resolution can be better than 8 cm.

  3. Challenges and key research questions for yaws eradication

    PubMed Central

    Marks, Michael; Mitjà, Oriol; Vestergaard, Lasse S; Pillay, Allan; Knauf, Sascha; Chen, Cheng-Yen; Bassat, Quique; Martin, Diana L.; Fegan, David; Taleo, Fasihah; Kool, Jacob; Lukehart, Sheila; Emerson, Paul M; Solomon, Anthony W; Ye, Tun; Ballard, Ronald C; Mabey, David CW; Asiedu, Kingsley B

    2015-01-01

    Yaws is endemic in West Africa, Southeast Asia and the Pacific. The WHO has launched a campaign based on mass treatment with azithromycin, to eradicate yaws by 2020. Progress has been made towards achieving this ambitious goal, including the validation of point-of-care and molecular diagnostic tests and piloting of the strategy in a number of countries including Ghana, Vanuatu and Papua New Guinea. There is a need to address gaps in knowledge to allow refinement of the eradication strategy. Studies exploring determinants of the spatial distribution of yaws are needed to facilitate completion of baseline mapping. The finding that Haemophilus ducreyi causes lesions similar to yaws is particularly important and further work is required to assess the impact of azithromycin on these lesions. The integration of diagnostic tests in to different stages of the eradication campaign requires evaluation. Finally studies to inform the optimum mass treatment strategy for sustainably interrupting transmission must be conducted. PMID:26362174

  4. Challenges and key research questions for yaws eradication.

    PubMed

    Marks, Michael; Mitjà, Oriol; Vestergaard, Lasse S; Pillay, Allan; Knauf, Sascha; Chen, Cheng-Yen; Bassat, Quique; Martin, Diana L; Fegan, David; Taleo, Fasihah; Kool, Jacob; Lukehart, Sheila; Emerson, Paul M; Solomon, Anthony W; Ye, Tun; Ballard, Ronald C; Mabey, David C W; Asiedu, Kingsley B

    2015-10-01

    Yaws is endemic in west Africa, southeast Asia, and the Pacific region. To eradicate yaws by 2020, WHO has launched a campaign of mass treatment with azithromycin. Progress has been made towards achievement of this ambitious goal, including the validation of point-of-care and molecular diagnostic tests and piloting of the strategy in several countries, including Ghana, Vanuatu, and Papua New Guinea. Gaps in knowledge need to be addressed to allow refinement of the eradication strategy. Studies exploring determinants of the spatial distribution of yaws are needed to help with the completion of baseline mapping. The finding that Haemophilus ducreyi causes lesions similar to yaws is particularly important and further work is needed to assess the effect of azithromycin on these lesions. The integration of diagnostic tests into different stages of the eradication campaign needs investigation. Finally, studies must be done to inform the optimum mass-treatment strategy for sustainable interruption of transmission. PMID:26362174

  5. Findings

    MedlinePlus

    ... Issue All Issues Explore Findings by Topic Cell Biology Cellular Structures, Functions, Processes, Imaging, Stress Response Chemistry ... Glycobiology, Synthesis, Natural Products, Chemical Reactions Computers in Biology Bioinformatics, Modeling, Systems Biology, Data Visualization Diseases Cancer, ...

  6. The village/commune safety policy and HIV prevention efforts among key affected populations in Cambodia: finding a balance

    PubMed Central

    2012-01-01

    The Village/Commune Safety Policy was launched by the Ministry of Interior of the Kingdom of Cambodia in 2010 and, due to a priority focus on “cleaning the streets”, has created difficulties for HIV prevention programs attempting to implement programs that work with key affected populations including female sex workers and people who inject drugs. The implementation of the policy has forced HIV program implementers, the UN and various government counterparts to explore and develop collaborative ways of delivering HIV prevention services within this difficult environment. The following case study explores some of these efforts and highlights the promising development of a Police Community Partnership Initiative that it is hoped will find a meaningful balance between the Village/Commune Safety Policy and HIV prevention efforts with key affected populations in Cambodia. PMID:22770267

  7. The village/commune safety policy and HIV prevention efforts among key affected populations in Cambodia: finding a balance.

    PubMed

    Thomson, Nick; Leang, Supheap; Chheng, Kannarath; Weissman, Amy; Shaw, Graham; Crofts, Nick

    2012-01-01

    The Village/Commune Safety Policy was launched by the Ministry of Interior of the Kingdom of Cambodia in 2010 and, due to a priority focus on "cleaning the streets", has created difficulties for HIV prevention programs attempting to implement programs that work with key affected populations including female sex workers and people who inject drugs. The implementation of the policy has forced HIV program implementers, the UN and various government counterparts to explore and develop collaborative ways of delivering HIV prevention services within this difficult environment. The following case study explores some of these efforts and highlights the promising development of a Police Community Partnership Initiative that it is hoped will find a meaningful balance between the Village/Commune Safety Policy and HIV prevention efforts with key affected populations in Cambodia. PMID:22770267

  8. Key Competencies and Characteristics for Innovative Teaching among Secondary School Teachers: A Mixed-Methods Research

    ERIC Educational Resources Information Center

    Zhu, Chang; Wang, Di

    2014-01-01

    This research aims to understand the key competencies and characteristics for innovative teaching as perceived by Chinese secondary teachers. A mixed-methods research was used to investigate secondary teachers' views. First, a qualitative study was conducted with interviews of teachers to understand the perceived key competencies and…

  9. ALPBP Project Research Component: Summary of Research Findings and Final Reports.

    ERIC Educational Resources Information Center

    Rivera, Charlene

    This report summarizes the Assessment of Language Proficiency of Bilingual Persons (ALPBP) project research component and provides a summary of the findings of the other six components of the study. The summary of the research component includes an outline of the goals, activities, and requests for proposals. After the introduction, the following…

  10. Psychological Therapies for Auditory Hallucinations (Voices): Current Status and Key Directions for Future Research

    PubMed Central

    Thomas, Neil; Hayward, Mark; Peters, Emmanuelle; van der Gaag, Mark; Bentall, Richard P.; Jenner, Jack; Strauss, Clara; Sommer, Iris E.; Johns, Louise C.; Varese, Filippo; García-Montes, José Manuel; Waters, Flavie; Dodgson, Guy; McCarthy-Jones, Simon

    2014-01-01

    This report from the International Consortium on Hallucinations Research considers the current status and future directions in research on psychological therapies targeting auditory hallucinations (hearing voices). Therapy approaches have evolved from behavioral and coping-focused interventions, through formulation-driven interventions using methods from cognitive therapy, to a number of contemporary developments. Recent developments include the application of acceptance- and mindfulness-based approaches, and consolidation of methods for working with connections between voices and views of self, others, relationships and personal history. In this article, we discuss the development of therapies for voices and review the empirical findings. This review shows that psychological therapies are broadly effective for people with positive symptoms, but that more research is required to understand the specific application of therapies to voices. Six key research directions are identified: (1) moving beyond the focus on overall efficacy to understand specific therapeutic processes targeting voices, (2) better targeting psychological processes associated with voices such as trauma, cognitive mechanisms, and personal recovery, (3) more focused measurement of the intended outcomes of therapy, (4) understanding individual differences among voice hearers, (5) extending beyond a focus on voices and schizophrenia into other populations and sensory modalities, and (6) shaping interventions for service implementation. PMID:24936081

  11. Finding a Mentor for High School Independent Scientific Research

    ERIC Educational Resources Information Center

    Hess, Amber

    2008-01-01

    Being involved with scientific research in high school is rewarding and fun. Research enables students to: (1) learn in depth about a particular area; (2) meet other students who are also enthusiastic about learning and who have done amazing research; and (3) earn scholarships for college if the research is entered in competitions. Completing a…

  12. Evaluating Teaching and Research Activities--Finding the Right Balance.

    ERIC Educational Resources Information Center

    Vidal, Javier; Mora, Jose-Gines

    2003-01-01

    Analyzes on a national, regional, and institutional level the evaluation systems used to assess teaching and research activities at Spanish universities. Also examines ways in which evaluation systems orient to promote research activities to the detriment of teaching activities. (SWM)

  13. Neurobiology Research Findings: How the Brain Works during Reading

    ERIC Educational Resources Information Center

    Kweldju, Siusana

    2015-01-01

    In the past, neurobiology for reading was identical with neuropathology. Today, however, the advancement of modern neuroimaging techniques has contributed to the understanding of the reading processes of normal individuals. Neurobiology findings today have uncovered and illuminated the fundamental neural mechanism of reading. The findings have…

  14. School-Based Performance Awards: Research Findings and Future Directions.

    ERIC Educational Resources Information Center

    Kelley, Carolyn; Heneman, Herbert, III; Milanowski, Anthony

    This paper synthesizes research on how motivation influenced teachers at two school-based performance award (SBPA) programs in Kentucky and in North Carolina. The research was conducted between 1995 and 1998 by the Consortium for Policy Research in Education. SBPA programs provide teachers and other school staff with pay bonuses for the…

  15. FACTORS INFLUENCING UTILIZATION OF RESEARCH FINDINGS IN INSTITUTIONAL CHANGE.

    ERIC Educational Resources Information Center

    LYONS, J. DANIEL

    CHANGES IN ARMY TRAINING PROGRAMS AND PROCEDURES ARE DESCRIBED TO ILLUSTRATE INSTITUTIONAL CHANGE RESULTING FROM IMPLEMENTATION OF APPLIED RESEARCH. SERVING SINCE 1951 AS A RESEARCH AND DEVELOPMENT AGENCY UNDER CONTRACT TO THE ARMY, THE HUMAN RESOURCES RESEARCH OFFICE OF GEORGE WASHINGTON UNIVERSITY HAS IDENTIFIED INSTITUTIONAL CHANGE THROUGH…

  16. Speaking up about Advocacy: Findings from a Partnership Research Project

    ERIC Educational Resources Information Center

    Chapman, Melanie; Bannister, Susan; Davies, Julie; Fleming, Simon; Graham, Claire; Mcmaster, Andrea; Seddon, Angela; Wheldon, Anita; Whittell, Bridget

    2012-01-01

    This article describes a partnership research project carried out by a research team consisting of people with learning disabilities and people without learning disabilities. The research explored people's understandings of advocacy and identified gaps in advocacy provision for people with learning disabilities and their families. Four focus…

  17. Vulnerable Children's Access to Examinations at Key Stage 4. Research Report RR639

    ERIC Educational Resources Information Center

    Kendall, Sally; Johnson, Annie; Martin, Kerry; Kinder; Kay

    2005-01-01

    This research project was commissioned by the Department for Education and Skills (DfES) in 2004 to examine barriers to vulnerable children accessing examinations at the end of key stage 4 and to identify strategies employed to overcome these barriers. Key groups of vulnerable children identified by the DfES included: (1) Looked-after children;…

  18. Reading Journal Articles for Comprehension Using Key Sentences: An Exercise for the Novice Research Student

    ERIC Educational Resources Information Center

    Bennett, Nicole S.; Taubman, Brett F.

    2013-01-01

    We have incorporated an active-learning assignment, Reading Papers Using Key Sentences, in an upper-level Introduction to Chemical Research course. Although key sentences are typically used to help authors write with clarity and organization, we have found that this assignment helps students improve upon and practice reading journal articles for…

  19. Finding Qualitative Research Evidence for Health Technology Assessment.

    PubMed

    DeJean, Deirdre; Giacomini, Mita; Simeonov, Dorina; Smith, Andrea

    2016-08-01

    Health technology assessment (HTA) agencies increasingly use reviews of qualitative research as evidence for evaluating social, experiential, and ethical aspects of health technologies. We systematically searched three bibliographic databases (MEDLINE, CINAHL, and Social Science Citation Index [SSCI]) using published search filters or "hedges" and our hybrid filter to identify qualitative research studies pertaining to chronic obstructive pulmonary disease and early breast cancer. The search filters were compared in terms of sensitivity, specificity, and precision. Our screening by title and abstract revealed that qualitative research constituted only slightly more than 1% of all published research on each health topic. The performance of the published search filters varied greatly across topics and databases. Compared with existing search filters, our hybrid filter demonstrated a consistently high sensitivity across databases and topics, and minimized the resource-intensive process of sifting through false positives. We identify opportunities for qualitative health researchers to improve the uptake of qualitative research into evidence-informed policy making. PMID:27117960

  20. Applying Ad Hoc Institutional Research Findings to College Strategic Planning

    ERIC Educational Resources Information Center

    Clagett, Craig A.

    2004-01-01

    Environmental scanning, enrollment forecasting, budget analyses, and institutional effectiveness assessment are examples of the explicit contributions institutional research offices make to campus strategic planning.

  1. "Response to Comments": Finding the Narrative in Narrative Research

    ERIC Educational Resources Information Center

    Coulter, Cathy A.

    2009-01-01

    The author responds to comments by Barone (2009), Clandinin and Murphy (2009), and M. W. Smith (2009) on "The Construction Zone: Literary Elements in Narrative Research" (Coulter & M. L. Smith, 2009). She clarifies issues regarding point of view, authorial surplus, narrative coherence, and the relational qualities of narrative research. She…

  2. Family Caregiving and the Elderly: Policy Recommendations and Research Findings.

    ERIC Educational Resources Information Center

    New York State Office for the Aging, Albany.

    This report is designed to assist in the formulation of public policy as it relates to older people and their families by setting forth a comprehensive research-based framework to guide future public action in this area. It is intended for use by public officials, agency administrators, researchers, and academicians, as well as members of the…

  3. Rutgers University Research Experience for Teachers in Engineering: Preliminary Findings

    ERIC Educational Resources Information Center

    Laffey, Evelyn H.; Cook-Chennault, Kimberly; Hirsch, Linda S.

    2013-01-01

    In addressing the nation's need for a more technologically-literate society, the Rutgers University Research Experience for Teachers in Engineering (RU RET-E) is designed to: (1) engage middle and high school math and science teachers in innovative "green" engineering research during the summer, and (2) support teachers in integrating…

  4. Finding Nexus: Connecting Youth Work and Research Practices

    ERIC Educational Resources Information Center

    Gormally, Sinéad; Coburn, Annette

    2014-01-01

    Participation in educational and social research helps to develop understanding of how young people learn and to consider wider aspects of their lives to enable their voices to be heard and acted upon. Research also facilitates the articulation and sharing of methodologies across a range of professional practices. We assert that theory and…

  5. Seeking Renewal, Finding Community: Participatory Action Research in Teacher Education

    ERIC Educational Resources Information Center

    Draper, Roni Jo; Adair, Marta; Broomhead, Paul; Gray, Sharon; Grierson, Sirpa; Hendrickson, Scott; Jensen, Amy P.; Nokes, Jeffery D.; Shumway, Steven; Siebert, Daniel; Wright, Geoffrey

    2011-01-01

    This narrative study describes the experiences of a group of teacher educators as they worked together in a collaborative research activity investigating theories of literacy and the preparation of secondary teachers. The collaboration was organized around the precepts associated with participatory action research (PAR). After four years of…

  6. An Introduction to Key Event Mapping: A Primer for Nurse Researchers

    PubMed Central

    Carter-Harris, Lisa

    2015-01-01

    To fully understand the events leading to a diagnosis, retrospective recall can help nurse researchers reconstruct important health behavior-related events. However, retrospective recall can be a challenge. Key event mapping offers nurse researchers a method beyond retrospective chart review to elicit date data to explore the pre-diagnosis time frame of an illness. The purpose of this paper is to introduce the key event mapping method to nurse researchers in search of a method of eliciting date data from participants when designing research studies that include a retrospective recall component. PMID:25908543

  7. Putting nursing research findings into practice: research utilization as an aspect of the management of change.

    PubMed

    MacGuire, J M

    1990-05-01

    This paper discusses a number of different levels at which the implementation of nursing research findings needs to be addressed and identifies 10 areas of potential difficulty: the complexity of the change process, the genesis of research programmes, the formulation of research questions, differences in theoretical approaches, timescales and planning cycles, information overload, credibility, applicability, response to change and the management of change. An attempt is made to shift the nature of the discourse from the personal to the organizational and from a diffusionist perspective to that of change management. It is suggested that it is simplistic to regard the apparent lack of take-up of research-based practice findings as a failure on the part of individual nurses to respond rationally to the production of new information. The integration of research and practice has to be addressed at all levels within an organization; from policy statements to procedure manuals and from managers, educators and clinicians to support workers within the framework of the management of change. The potential of action research and quality circles in this context is touched on. PMID:2358579

  8. Researchers Find Order, Beauty in Chaotic Chemical Systems.

    ERIC Educational Resources Information Center

    Borman, Stu

    1991-01-01

    Deterministic chaos which involves orderly motion is discussed. Presented is the history of chaos and two tests for chaos. Practical applications and predictions of the long-term significance of chaos research are discussed. (KR)

  9. Keyboarding Issues in Elementary Education: Some Research Findings.

    ERIC Educational Resources Information Center

    Kercher, Lydia; McClurg, Patricia

    This paper explores the issue of how, when, and where to teach keyboarding at the elementary school level through a review of the keyboarding literature and descriptions of three studies conducted with fifth grade students in the laboratory school at the University of Wyoming. The literature review briefly summarizes findings on the following…

  10. 42 CFR 93.104 - Requirements for findings of research misconduct.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Requirements for findings of research misconduct... HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT General § 93.104 Requirements for findings of research misconduct. A finding of research misconduct made under this part requires that— (a) There be a...

  11. 42 CFR 93.104 - Requirements for findings of research misconduct.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Requirements for findings of research misconduct... HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT General § 93.104 Requirements for findings of research misconduct. A finding of research misconduct made under this part requires that— (a) There be a...

  12. 42 CFR 93.104 - Requirements for findings of research misconduct.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Requirements for findings of research misconduct... HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT General § 93.104 Requirements for findings of research misconduct. A finding of research misconduct made under this part requires that— (a) There be a...

  13. 42 CFR 93.104 - Requirements for findings of research misconduct.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Requirements for findings of research misconduct... HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT General § 93.104 Requirements for findings of research misconduct. A finding of research misconduct made under this part requires that— (a) There be a...

  14. Key findings from HSC's 2010 site visits: health care markets weather economic downturn, brace for health reform.

    PubMed

    Felland, Laurie E; Grossman, Joy M; Tu, Ha T

    2011-05-01

    Lingering fallout--loss of jobs and employer coverage--from the great recession slowed demand for health care services but did little to slow aggressive competition by dominant hospital systems for well-insured patients, according to key findings from the Center for Studying Health System Change's (HSC) 2010 site visits to 12 nationally representative metropolitan communities. Hospitals with significant market clout continued to command high payment rate increases from private insurers, and tighter hospital-physician alignment heightened concerns about growing provider market power. High and rising premiums led to increasing employer adoption of consumer-driven health plans and continued increases in patient cost sharing, but the broader movement to educate and engage consumers in care decisions did not keep pace. State and local budget deficits led to some funding cuts for safety net providers, but an influx of federal stimulus funds increased support to community health centers and shored up Medicaid programs, allowing many people who lost private insurance because of job losses to remain covered. Hospitals, physicians and insurers generally viewed health reform coverage expansions favorably, but all worried about protecting revenues as reform requirements phase in. PMID:21614861

  15. Incorporating Research Findings into Standards and Requirements for Space Medicine

    NASA Technical Reports Server (NTRS)

    Duncan, J. Michael

    2006-01-01

    The Vision for Exploration has been the catalyst for NASA to refocus its life sciences research. In the future, life sciences research funded by NASA will be focused on answering questions that directly impact setting physiological standards and developing effective countermeasures to the undesirable physiological and psychological effects of spaceflight for maintaining the health of the human system. This, in turn, will contribute to the success of exploration class missions. We will show how research will impact setting physiologic standards, such as exposure limits, outcome limits, and accepted performance ranges. We will give examples of how a physiologic standard can eventually be translated into an operational requirement, then a functional requirement, and eventually spaceflight hardware or procedures. This knowledge will be important to the space medicine community as well as to vehicle contractors who, for the first time, must now consider the human system in developing and constructing a vehicle that can achieve the goal of success.

  16. Finding Collaborators: Toward Interactive Discovery Tools for Research Network Systems

    PubMed Central

    Schleyer, Titus K; Becich, Michael J; Hochheiser, Harry

    2014-01-01

    Background Research networking systems hold great promise for helping biomedical scientists identify collaborators with the expertise needed to build interdisciplinary teams. Although efforts to date have focused primarily on collecting and aggregating information, less attention has been paid to the design of end-user tools for using these collections to identify collaborators. To be effective, collaborator search tools must provide researchers with easy access to information relevant to their collaboration needs. Objective The aim was to study user requirements and preferences for research networking system collaborator search tools and to design and evaluate a functional prototype. Methods Paper prototypes exploring possible interface designs were presented to 18 participants in semistructured interviews aimed at eliciting collaborator search needs. Interview data were coded and analyzed to identify recurrent themes and related software requirements. Analysis results and elements from paper prototypes were used to design a Web-based prototype using the D3 JavaScript library and VIVO data. Preliminary usability studies asked 20 participants to use the tool and to provide feedback through semistructured interviews and completion of the System Usability Scale (SUS). Results Initial interviews identified consensus regarding several novel requirements for collaborator search tools, including chronological display of publication and research funding information, the need for conjunctive keyword searches, and tools for tracking candidate collaborators. Participant responses were positive (SUS score: mean 76.4%, SD 13.9). Opportunities for improving the interface design were identified. Conclusions Interactive, timeline-based displays that support comparison of researcher productivity in funding and publication have the potential to effectively support searching for collaborators. Further refinement and longitudinal studies may be needed to better understand the

  17. Finding paradigms for the future of alcoholism research: an interdisciplinary perspective.

    PubMed

    Meyer, R E

    2001-09-01

    This is a review article and critique of current research strategies in the alcohol field. Although the alcohol field is proud of its multidisciplinary tradition and scientific findings within specific disciplines, there are very few models of cross-disciplinary research and communication. Currently, the favored model of risk is genetic; the favored model of pathophysiology is molecular neuroscience; and the favored model of clinical investigation is narrowly categorical. If there is a hierarchy within science that is based on explanatory power, then models of alcoholism emerging from neuroscience, molecular biology, and genetics should be able to accommodate (if not account for) the findings on clinical aspects of alcohol dependence, as well as data on differential risk, course, and recovery that come from the behavioral and social sciences. The first section of this article reviews the most popular models of alcohol dependence over the past 40 years. I argue that the currently fashionable categorical approach to diagnosis in DSM-IV (and ICD-10) has failed to serve as a framework for interdisciplinary research and has failed to meet the needs of human geneticists, population-based researchers, psychosocial researchers, basic scientists working in animal models, and patient-oriented researchers. I argue for a return to the dimensional approach to diagnosis in the alcohol dependence syndrome construct. In the second section of the article, I lay out an agenda for revitalized patient-oriented research in the alcohol field, as a bridge between basic biological research and innovations in clinical practice, as well as the key to a valid diagnostic system that can inform research strategies in genetics and population-based research. In the third section of the article, I highlight the interface between genetic and psychosocial models of risk and propose a possible structure for future collaboration. I conclude with a plea to funding agencies and investigators to

  18. Instrumentation Technology. Project Report Phase I with Research Findings.

    ERIC Educational Resources Information Center

    Sappe', Hoyt; Squires, Sheila S.

    This report provides results of Phase I of a project that researched the occupational area of instrumentation technology, established appropriate committees, and conducted task verification. These results are intended to guide development of a program designed to train instrumentation technicians. Section 1 contains general information: purpose of…

  19. Emergency Medical Services. Project Report Phase I with Research Findings.

    ERIC Educational Resources Information Center

    Sappe', Hoyt; Squires, Sheila S.

    This report provides results of Phase I of a project that researched the occupational area of emergency medical services (EMS), established appropriate committees, and conducted task verification. These results are intended to guide development of a program designed to train paramedics. Section 1 contains general information: purpose of Phase I;…

  20. Commercial Photography. Project Report Phase I with Research Findings.

    ERIC Educational Resources Information Center

    Brown, Ted; Sappe', Hoyt

    This report provides results of Phase I of a project that researched the occupational area of commercial photography, established appropriate committees, and conducted task verification. These results are intended to guide development of a program designed to train photographic technicians. Section 1 contains general information: purpose of Phase…

  1. Most Colleges Chase Prestige on a Treadmill, Researchers Find

    ERIC Educational Resources Information Center

    Schmidt, Peter

    2008-01-01

    The pursuit of institutional prestige has done little to improve the reputations of most colleges, and it may be causing many of them to become less distinguishable from their competitors, new research shows. In one study presented at the annual conference of the Association for the Study of Higher Education, Kyle V. Sweitzer, a data-resource…

  2. LEADERSHIP IN SMALL MILITARY UNITS--SOME RESEARCH FINDINGS.

    ERIC Educational Resources Information Center

    LANGE, CARL J.

    THE EFFECT OF A LEADER'S ACTIONS ON HIS FOLLOWERS IN SMALL MILITARY UNITS WAS THE SUBJECT OF SEVERAL RESEARCH STUDIES CONDUCTED TO EXPLORE THE NATURE OF THE LEADERSHIP PROCESS, WITH THE ULTIMATE GOAL OF DEVELOPING TRAINING THAT WOULD USE IMPROVED PRESENTATIONAL MATERIALS AND WOULD BE BASED ON LEADERSHIP DOCTRINE WITH DEMONSTRATED VALIDITY. THE…

  3. Emerging Answers: Research Findings on Programs To Reduce Teen Pregnancy.

    ERIC Educational Resources Information Center

    Kirby, Douglas

    This report summarizes three bodies of research on teenage pregnancy and programs to reduce the risk of teenage pregnancy. Studies included in this report were completed in 1980 or later, conducted in the United States or Canada, targeted adolescents, employed an experimental or quasi-experimental design, had a sample size of at least 100 in the…

  4. Employee Retention at ABC & Co. Northwest Arkansas. Research Findings.

    ERIC Educational Resources Information Center

    Hatcher, Timothy; And Others

    A 7-month research project was conducted by graduate students at a garment manufacturing plant in Fayetteville, Arkansas, to gain information about high employee turnover. Information also was gathered about the employment situation in northwest Arkansas in general, union-labor relationships, and how other companies handled turnover. Data were…

  5. Urban Delinquency and Substance Abuse. Initial Findings. Research Summary.

    ERIC Educational Resources Information Center

    Huizinga, David; Loeber, Rolf; Thornberry, Terence P.

    In collaborative efforts three research teams have investigated the problems of urban delinquency and substance abuse in longitudinal studies that have gone on since 1986. The Denver Youth Study is a longitudinal survey that involves annual interviews with probability samples of five different birth cohorts and their parents from areas of Denver…

  6. Process Analysis and Documentation for Utilization of Research Findings.

    ERIC Educational Resources Information Center

    Young, Flora

    This document reports on an investigation which surveyed process analysis and documentation concepts, practices, and standards in light of the need for communicating the processes and outcomes of educational research and development. The survey demonstrated that the areas of impartial process analysis and documentation are both important and…

  7. Electrical Distribution. Project Report Phase I with Research Findings.

    ERIC Educational Resources Information Center

    Sappe', Hoyt; Kirkpatrick, Thomas

    This report provides results of Phase I of a project that researched the occupational area of electrical distribution, established appropriate committees, and conducted task verification. These results are intended to guide development of a program designed to train apprentice line workers. Section 1 contains general information: purpose of Phase…

  8. Finding a place for genomics in health disparities research.

    PubMed

    Fullerton, S M; Knerr, S; Burke, W

    2012-01-01

    The existence of pronounced differences in health outcomes between US populations is a problem of moral significance and public health urgency. Pursuing research on genetic contributors to such disparities, despite striking data on the fundamental role of social factors, has been controversial. Still, advances in genomic science are providing an understanding of disease biology at a level of precision not previously possible. The potential for genomic strategies to help in addressing population-level disparities therefore needs to be carefully evaluated. Using 3 examples from current research, we argue that the best way to maximize the benefits of population-based genomic investigations, and mitigate potential harms, is to direct research away from the identification of genetic causes of disparities and instead focus on applying genomic methodologies to the development of clinical and public health tools with the potential to ameliorate healthcare inequities, direct population-level health interventions or inform public policy. Such a transformation will require close collaboration between transdisciplinary teams and community members as well as a reorientation of current research objectives to better align genomic discovery efforts with public health priorities and well-recognized barriers to fair health care delivery. PMID:22488458

  9. FINDING THE BALANCE - QUALITY ASSURANCE REQUIREMENTS VS. RESEARCH NEEDS

    EPA Science Inventory

    Investigators often misapply quality assurance (QA) procedures and may consider QA as a hindrance to developing test plans for sampling and analysis. If used properly, however, QA is the driving force for collecting the right kind and proper amount of data. Researchers must use Q...

  10. FINDING THE BALANCE - QUALITY ASSURANCE REQUIREMENTS VS. RESEARCH NEEDS

    EPA Science Inventory

    Investigators often misapply quality assurance (QA) procedures and may consider QA as a hindrance to developing test plans for
    sampling and analysis. If used properly, however, QA is the driving force for collecting the right kind and proper amount of data.
    Researchers must...

  11. Operationalizing Culturally Responsive Instruction: Preliminary Findings of CRIOP Research

    ERIC Educational Resources Information Center

    Powell, Rebecca; Cantrell, Susan Chambers; Malo-Juvera, Victor; Correll, Pamela

    2016-01-01

    Background: Many scholars have espoused the use of culturally responsive instruction (CRI) for closing achievement gaps, yet there is a paucity of research supporting its effectiveness. In this article, we share results of a mixed methods study that examined the use of the Culturally Responsive Instruction Observation Protocol (CRIOP) as a…

  12. Reconciling (Seemingly) Discrepant Findings: Implications for Practice and Future Research

    ERIC Educational Resources Information Center

    Bowman, Nicholas A.; Herzog, Serge

    2011-01-01

    Decades of research in survey methodology and psychology have yielded important insights about how to create effective and valid survey instruments. As Porter (in press) has argued convincingly, college student surveys often fall well short of these standards by placing unrealistic demands on students' memory and by assuming that students readily…

  13. Pain, Nicotine, and Smoking: Research Findings and Mechanistic Considerations

    ERIC Educational Resources Information Center

    Ditre, Joseph W.; Brandon, Thomas H.; Zale, Emily L.; Meagher, Mary M.

    2011-01-01

    Tobacco addiction and chronic pain represent 2 highly prevalent and comorbid conditions that engender substantial burdens upon individuals and systems. Interrelations between pain and smoking have been of clinical and empirical interest for decades, and research in this area has increased dramatically over the past 5 years. We conceptualize the…

  14. Researchers Find Essential Brain Circuit in Visual Development

    MedlinePlus

    ... If this circuit could be controlled in the human brain — for example, with a drug or with implants ... the nation’s leading funder of research on the brain and nervous system. The ... of Health and Human Services. NIH is the primary federal agency conducting ...

  15. THE IMPACT OF TELEVISION, METHODS AND FINDINGS IN PROGRAM RESEARCH.

    ERIC Educational Resources Information Center

    BELSON, W.A.

    SURVEY AND TESTING TECHNIQUES USED BY THE BRITISH BROADCASTING CORPORATION IN THE YEARS 1952-63 TO ANSWER QUESTIONS OF INTEREST TO TELEVISION PLANNERS INDICATE METHODOLOGY FOR FUTURE PLANNING RESEARCH. TO ANSWER THE BASIC QUESTION--WHAT PEOPLE ARE AVAILABLE FOR WATCHING AND LISTENING--BBC USED THE METHOD OF HAVING 2981 MEMBERS OF A NATIONAL SAMPLE…

  16. Finding Community: A Guide to Community Research and Action.

    ERIC Educational Resources Information Center

    Jones, W. Ron; And Others

    For those concerned with contemporary social problems, whether as students, members of community groups, or individual citizens, this book attempts not only to describe the issues, but also to offer some starting points for local research and action. As an educational tool, it is based on the belief that a good way to learn about a community is to…

  17. Graphic Organizers in Reading Instruction: Research Findings and Issues

    ERIC Educational Resources Information Center

    Jiang, Xiangying; Grabe, William

    2007-01-01

    As an instructional tool, graphic organizers (GOs) have been highly recommended and used in contemporary classrooms. Over the past decade, a number of concerns have been raised about claims for the effectiveness of GOs. These concerns involve the inconsistent research results on student improvements, the limitation in generalizability from…

  18. Sheet Metal Contract. Project Report Phase I with Research Findings.

    ERIC Educational Resources Information Center

    Kirkpatrick, Thomas; Sappe', Hoyt

    This report provides results of Phase I of a project that researched the occupational area of sheet metal, established appropriate committees, and conducted task verification. These results are intended to guide development of a program designed to train sheet metal workers. Section 1 contains general information: purpose of Phase I; description…

  19. Research on Interest in Science: Theories, Methods, and Findings

    ERIC Educational Resources Information Center

    Krapp, Andreas; Prenzel, Manfred

    2011-01-01

    This article presents an overview of interest research and describes the theoretical and methodological background for the assessment of interest in science in large-scale assessments like the "Programme for International Student Assessment" (PISA). The paper starts with a short retrospective on the history of interest, bringing out theoretical…

  20. Dental Laboratory Technology. Project Report Phase I with Research Findings.

    ERIC Educational Resources Information Center

    Sappe', Hoyt; Smith, Debra S.

    This report provides results of Phase I of a project that researched the occupational area of dental laboratory technology, established appropriate committees, and conducted task verification. These results are intended to guide development of a program designed to train dental laboratory technicians. Section 1 contains general information:…

  1. Children of substance abusers: overview of research findings.

    PubMed

    Johnson, J L; Leff, M

    1999-05-01

    A relationship between parental substance abuse and subsequent alcohol problems in their children has been documented extensively. Children of alcoholics (COAs) are considered to be at high risk because there is a greater likelihood that they will develop alcoholism compared with a randomly selected child from the same community. COAs and children of other drug-abusing parents are especially vulnerable to the risk for maladaptive behavior because they have combinations of many risk factors present in their lives. The single most potent risk factor is their parent's substance-abusing behavior. This single risk factor can place children of substance abusers at biologic, psychologic, and environmental risk. Since the turn of the century, many reports have described the deleterious influence of parental alcoholism on their children. A series of studies measured mortality, physiology, and general health in the offspring of alcoholic parents and concluded that when mothers stopped drinking during gestation, their children were healthier. Today, research on COAs can be classified into studies of fetal alcohol syndrome, the transmission of alcoholism, psychobiologic markers of vulnerability, and psychosocial characteristics. Each of these studies hypothesizes that differences between COAs and children of nonalcoholics influence maladaptive behaviors later in life, such as academic failure or alcoholism. This research supports the belief that COAs are at risk for a variety of problems that may include behavioral, psychologic, cognitive, or neuropsychologic deficits. The vast literature on COAs far outweighs the literature on children of other drug abusers. Relatively little is known about children of heroin addicts, cocaine abusers, or polydrug abusers. Nonetheless, many researchers suggest that the children of addicted parents are at greater risk for later dysfunctional behaviors and that they, too, deserve significant attention to prevent intergenerational transmission of

  2. Mental health epidemiological research in South America: recent findings

    PubMed Central

    Silva de Lima, Maurício; Garcia de Oliveira Soares, Bernardo; de Jesus Mari, Jair

    2004-01-01

    This paper aims to review the recent mental health epidemiological research conducted in South America. The Latin American and the Caribbean (LILACS) database was searched from 1999 to 2003 using a specific strategy for identification of cohort, case-control and cross-sectional population-based studies in South America. The authors screened references and identified relevant studies. Further studies were obtained contacting local experts in epidemiology. 140 references were identified, and 12 studies were selected. Most selected studies explored the prevalence and risk factors for common mental disorders, and several of them used sophisticated methods of sample selection and analysis. There is a need for improving the quality of psychiatric journals in Latin America, and for increasing the distribution and access to research data. Regionally relevant problems such as violence and substance abuse should be considered in designing future investigations in this area. PMID:16633474

  3. Research Findings on Radiation Hormesis and Radon Therapy

    SciTech Connect

    Hattori, Sadao

    1999-06-06

    Radiation hormesis research in Japan to determine the validity of Luckey's claims has revealed information on the health effects of low-level radiation. The scientific data of animal tests we obtained and successful results actually brought by radon therapy on human patients show us a clearer understanding of the health effects of low-level radiation. We obtained many animal test results and epidemiological survey data through our research activities cooperating with more than ten universities in Japan, categorized as follows: 1. suppression of cancer by enhancement of the immune system based on gene activation; 2. rejuvenation and suppression of aging by increasing cell membrane permeability and enzyme syntheses; 3. adaptive response by activation of gene expression on DNA repair and cell apoptosis; 4. pain relief and stress moderation by hormone formation in the brain and central nervous system; 5. avoidance and therapy of obstinate diseases by enhancing damage control systems and form one formation.

  4. Pain, Nicotine, and Smoking: Research Findings and Mechanistic Considerations

    PubMed Central

    Ditre, Joseph W.; Brandon, Thomas H.; Zale, Emily L.; Meagher, Mary M.

    2011-01-01

    Tobacco addiction and chronic pain represent two highly prevalent and comorbid conditions that engender substantial burdens upon individuals and systems. Although interrelations between pain and smoking have been of clinical and empirical interest for decades, research on the topic of pain, nicotine, and tobacco smoking has increased dramatically over the past five years. We conceptualize the interaction of pain and smoking as a prototypical example of the biopsychosocial model. Accordingly, the current review extrapolated from behavioral, cognitive, affective, biomedical, and social perspectives to propose causal mechanisms that may contribute to the observed comorbidity between these two conditions. Research in the broad area of pain and smoking was first dichotomized into investigations of either "effects of smoking on pain" or "effects of pain on smoking." We then integrated the extant literature to present a reciprocal model of pain and smoking that is hypothesized to interact in the manner of a positive feedback loop, resulting in greater pain, increased smoking, and the maintenance of tobacco addiction. Finally, we proposed directions for future research, and discussed clinical implications for smokers with comorbid pain disorders. We observed modest evidence to support the notions that smoking may be a risk factor in the multifactorial etiology of some chronically painful conditions, and that the experience of pain may come to serve as a potent motivator of smoking. We also found that whereas animal studies yielded consistent support for direct pain-inhibitory effects of nicotine and tobacco smoke, results from human studies were much less consistent. Future research in the emerging area of pain and smoking has the potential to inform theoretical and clinical applications with respect to tobacco smoking, chronic pain, and their comorbid presentation. PMID:21967450

  5. Journals Find Many Images in Research Are Faked

    ERIC Educational Resources Information Center

    Young, Jeffrey R.

    2008-01-01

    Kristin Roovers was a postdoctoral fellow at the University of Pennsylvania with a bright career ahead of her--a trusted member of a research laboratory at the medical school studying the role of cell growth in diabetes. When an editor of "The Journal of Clinical Investigation" did a spot-check on one of her images for an article in 2005, Roovers'…

  6. Trends in Chicago's Schools across Three Eras of Reform: Summary of Key Findings. Research Summary

    ERIC Educational Resources Information Center

    Luppescu, Stuart; Allensworth, Elaine M.; Moore, Paul; de la Torre, Marisa; Murphy, James

    2011-01-01

    In 1988, U.S. Secretary of Education William Bennett proclaimed Chicago's public schools to be the worst in the nation. Since that time, Chicago has been at the forefront of urban school reform. Beginning with a dramatic move in 1990 to shift power away from the central office, through CEO Paul Vallas's use of standardized testing to hold schools…

  7. Identifying and preventing medical errors in patients with limited English proficiency: key findings and tools for the field.

    PubMed

    Wasserman, Melanie; Renfrew, Megan R; Green, Alexander R; Lopez, Lenny; Tan-McGrory, Aswita; Brach, Cindy; Betancourt, Joseph R

    2014-01-01

    Since the 1999 Institute of Medicine (IOM) report To Err is Human, progress has been made in patient safety, but few efforts have focused on safety in patients with limited English proficiency (LEP). This article describes the development, content, and testing of two new evidence-based Agency for Healthcare Research and Quality (AHRQ) tools for LEP patient safety. In the content development phase, a comprehensive mixed-methods approach was used to identify common causes of errors for LEP patients, high-risk scenarios, and evidence-based strategies to address them. Based on our findings, Improving Patient Safety Systems for Limited English Proficient Patients: A Guide for Hospitals contains recommendations to improve detection and prevention of medical errors across diverse populations, and TeamSTEPPS Enhancing Safety for Patients with Limited English Proficiency Module trains staff to improve safety through team communication and incorporating interpreters in the care process. The Hospital Guide was validated with leaders in quality and safety at diverse hospitals, and the TeamSTEPPS LEP module was field-tested in varied settings within three hospitals. Both tools were found to be implementable, acceptable to their audiences, and conducive to learning. Further research on the impact of the combined use of the guide and module would shed light on their value as a multifaceted intervention. PMID:24629098

  8. New insights into HIV epidemic in South Africa: key findings from the National HIV Prevalence, Incidence and Behaviour Survey, 2012.

    PubMed

    Zuma, Khangelani; Shisana, Olive; Rehle, Thomas M; Simbayi, Leickness C; Jooste, Sean; Zungu, Nompumelelo; Labadarios, Demetre; Onoya, Dorina; Evans, Meredith; Moyo, Sizulu; Abdullah, Fareed

    2016-01-01

    This article presents key findings from the 2012 HIV prevalence, incidence and behaviour survey conducted in South Africa and explores trends in the HIV epidemic. A representative household based survey collected behavioural and biomedical data among people of all ages. Chi-squared test for association and formal trend tests (2002, 2005, 2008 and 2012) were used to test for associations and trends in the HIV epidemic across the four surveys. In 2012 a total of 38 431 respondents were interviewed from 11 079 households; 28 997 (67.5%) of 42 950 eligible individuals provided blood specimens. HIV prevalence was 12.2% [95% CI: 11.4-13.1] in 2012 with prevalence higher among females 14.4% than males 9.9%. Adults aged 25-49 years were most affected, 25.2% [95% CI: 23.2-27.3]. HIV prevalence increased from 10.6% [95%CI: 9.8-11.6] in 2008 to 12.2% [95% CI: 11.4-13.1] in 2012 (p < 0.001). Antiretroviral treatment (ART) exposure doubled from 16.6% in 2008 to 31.2% in 2012 (p < 0.001). HIV incidence in 2012 among persons 2 years and older was 1.07% [95% CI: 0.87-1.27], with the highest incidence among Black African females aged 20-34 years at 4.5%. Sexual debut before 15 years was reported by 10.7% of respondents aged 15-24 years, and was significantly higher among male youth than female (16.7% vs. 5.0% respectively, p < 0.001). Reporting of multiple sexual partners in the previous 12 months increased from 11.5% in 2002 to 18.3% in 2012 (p < 0.001). Condom use at last sex dropped from 45.1% in 2008 to 36.2% in 2012 (p < 0.001). Levels of accurate HIV knowledge about transmission and prevention were low and had decreased between 2008 and 2012 from 31.5% to 26.8%. South Africa is on the right track with scaling up ART. However, there have been worrying increases in most HIV-related risk behaviours. These findings suggest that there is a need to scale up prevention methods that integrate biomedical, behavioural, social and structural prevention interventions to reverse the tide

  9. Key Findings of the AMAP 2015 Assessment on Black Carbon and Tropospheric Ozone as Arctic Climate Forcers

    NASA Astrophysics Data System (ADS)

    Quinn, P.

    2015-12-01

    emission from each sector and region) were also calculated. Key findings from the 2015 assessment will be presented.

  10. Gate valve and motor-operator research findings

    SciTech Connect

    Steele, R. Jr.; DeWall, K.G.; Watkins, J.C.; Russell, M.J.; Bramwell, D.

    1995-09-01

    This report provides an update on the valve research being sponsored by the US Nuclear Regulatory Commission (NRC) and conducted at the Idaho National Engineering Laboratory (INEL). The research addresses the need to provide assurance that motor-operated valves can perform their intended safety function, usually to open or close against specified (design basis) flow and pressure loads. This report describes several important developments: Two methods for estimating or bounding the design basis stem factor (in rising-stem valves), using data from tests less severe than design basis tests; a new correlation for evaluating the opening responses of gate valves and for predicting opening requirements; an extrapolation method that uses the results of a best effort flow test to estimate the design basis closing requirements of a gate valve that exhibits atypical responses (peak force occurs before flow isolation); and the extension of the original INEL closing correlation to include low- flow and low-pressure loads. The report also includes a general approach, presented in step-by-step format, for determining operating margins for rising-stem valves (gate valves and globe valves) as well as quarter-turn valves (ball valves and butterfly valves).

  11. Bioethanol from Lignocellulosic Biomass: Current Findings Determine Research Priorities

    PubMed Central

    Kang, Qian; Appels, Lise; Tan, Tianwei

    2014-01-01

    “Second generation” bioethanol, with lignocellulose material as feedstock, is a promising alternative for first generation bioethanol. This paper provides an overview of the current status and reveals the bottlenecks that hamper its implementation. The current literature specifies a conversion of biomass to bioethanol of 30 to ~50% only. Novel processes increase the conversion yield to about 92% of the theoretical yield. New combined processes reduce both the number of operational steps and the production of inhibitors. Recent advances in genetically engineered microorganisms are promising for higher alcohol tolerance and conversion efficiency. By combining advanced systems and by intensive additional research to eliminate current bottlenecks, second generation bioethanol could surpass the traditional first generation processes. PMID:25614881

  12. Discovery research: the scientific challenge of finding new antibiotics.

    PubMed

    Livermore, David M

    2011-09-01

    The dwindling supply of new antibiotics largely reflects regulatory and commercial challenges, but also a failure of discovery. In the 1990s the pharmaceutical industry abandoned its classical ways of seeking antibiotics and instead adopted a strategy that combined genomics with high-throughput screening of existing compound libraries. Too much emphasis was placed on identifying targets and molecules that bound to them, and too little emphasis was placed on the ability of these molecules to permeate bacteria, evade efflux and avoid mutational resistance; moreover, the compound libraries were systematically biased against antibiotics. The sorry result is that no antibiotic found by this strategy has yet entered clinical use and many major pharmaceutical companies have abandoned antibiotic discovery. Although a raft of start-up companies-variously financed by venture capital, charity or public money--are now finding new antibiotic compounds (some of them very promising in vitro or in early trials), their development through Phase III depends on financial commitments from large pharmaceutical companies, where the discouraging regulatory environment and the poor likely return on investment remain paramount issues. PMID:21700626

  13. Key Stakeholders' Perceptions of Motivators for Research Participation Among Individuals Who Are Incarcerated.

    PubMed

    Hanson, Bridget L; Faulkner, Sherilyn A; Brems, Christiane; Corey, Staci L; Eldridge, Gloria D; Johnson, Mark E

    2015-10-01

    Understanding motivations of research participants is crucial for developing ethical research protocols, especially for research with vulnerable populations. Through interviews with 92 institutional review board members, prison administrators, research ethicists, and researchers, we explored key stakeholders' perceptions of what motivates incarcerated individuals to participate in research. Primary motivators identified were a desire to contribute to society, gaining knowledge and health care, acquiring incentives, and obtaining social support. The potential for undue influence or coercion were also identified as motivators. These results highlight the need for careful analysis of what motivates incarcerated individuals to participate in research as part of developing or reviewing ethically permissible and responsible research protocols. Future research should expand this line of inquiry to directly include perspectives of incarcerated individuals. PMID:26283681

  14. Exploiting multimedia in reproductive science education: research findings.

    PubMed

    Senger, P L; Oki, A C; Trevisan, M S; McLean, D J

    2012-08-01

    Education in reproductive science is operating from an outdated paradigm of teaching and learning. Traditionally, reproductive education follows the pattern where students read a textbook, listen to instructor presentations, re-read the textbook and class notes and then complete a test. This paradigm is inefficient, costly and has not incorporated the potential that technology can offer with respect to increases in student learning. Further, teachers of reproductive science (and all of science for that matter) have little training in the use of documented methods of instructional design and cognitive psychology. Thus, most of us have learned to teach by repeating the approaches our mentors used (both good and bad). The technology now exists to explain complex topics using multimedia presentations in which digital animation and three-dimensional anatomical reconstructions greatly reduce time required for delivery while at the same time improving student understanding. With funding from the Small Business Innovation Research program through the U.S. Department of Education, we have developed and tested a multimedia approach to teaching complex concepts in reproductive physiology. The results of five separate experiments involving 1058 university students and 122 patients in an OB/GYN clinic indicate that students and patients learned as much or more in less time when viewing the multimedia presentations when compared to traditional teaching methodologies. PMID:22827348

  15. Quantitative research on the primary process: method and findings.

    PubMed

    Holt, Robert R

    2002-01-01

    Freud always defined the primary process metapsychologically, but he described the ways it shows up in dreams, parapraxes, jokes, and symptoms with enough observational detail to make it possible to create an objective, reliable scoring system to measure its manifestations in Rorschach responses, dreams, TAT stories, free associations, and other verbal texts. That system can identify signs of the thinker's efforts, adaptive or maladaptive, to control or defend against the emergence of primary process. A prerequisite and a consequence of the research that used this system was clarification and elaboration of the psychoanalytic theory of thinking. Results of empirical tests of several propositions derived from psychoanalytic theory are summarized. Predictions concerning the method's most useful index, of adaptive vs. maladaptive regression, have been repeatedly verified: People who score high on this index (who are able to produce well-controlled "primary products" in their Rorschach responses), as compared to those who score at the maladaptive pole (producing primary-process-filled responses with poor reality testing, anxiety, and pathological defensive efforts), are better able to tolerate sensory deprivation, are more able to enter special states of consciousness comfortably (drug-induced, hypnotic, etc.), and have higher achievements in artistic creativity, while schizophrenics tend to score at the extreme of maladaptive regression. Capacity for adaptive regression also predicts success in psychotherapy, and rises with the degree of improvement after both psychotherapy and drug treatment. Some predictive failures have been theoretically interesting: Kris's hypothesis about creativity and the controlled use of primary process holds for males but usually not for females. This body of work is presented as a refutation of charges, brought by such critics as Crews, that psychoanalysis cannot become a science. PMID:12206540

  16. Frontal alpha asymmetry as a pathway to behavioural withdrawal in depression: Research findings and issues.

    PubMed

    Jesulola, Emmanuel; Sharpley, Christopher F; Bitsika, Vicki; Agnew, Linda L; Wilson, Peter

    2015-10-01

    Depression has been described as a process of behavioural withdrawal from overwhelming aversive stressors, and which manifests itself in the diagnostic symptomatology for Major Depressive Disorder (MDD). The underlying neurobiological pathways to that behavioural withdrawal are suggested to include greater activation in the right vs the left frontal lobes, described as frontal EEG asymmetry. However, despite a previous meta-analysis that provided overall support for this EEG asymmetry hypothesis, inconsistencies and several methodological confounds exist. The current review examines the literature on this issue, identifies inconsistencies in findings and discusses several key research issues that require addressing for this field to move towards a defensible theoretical model of depression and EEG asymmetry. In particular, the position of EEG asymmetry in the brain, measurement of severity and symptoms profiles of depression, and the effects of gender are considered as potential avenues to more accurately define the specific nature of the depression-EEG asymmetry association. PMID:26051816

  17. 42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Findings of research misconduct and proposed... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.404 Findings of research misconduct and...

  18. 42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Findings of research misconduct and proposed... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.404 Findings of research misconduct and...

  19. 42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Findings of research misconduct and proposed... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.404 Findings of research misconduct and...

  20. 42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Findings of research misconduct and proposed... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.404 Findings of research misconduct and...

  1. The current structure of key actors involved in research on land and soil degradation

    NASA Astrophysics Data System (ADS)

    Escadafal, Richard; Barbero, Celia; Exbrayat, Williams; Marques, Maria Jose; Ruiz, Manuel; El Haddadi, Anass; Akhtar-Schuster, Mariam

    2013-04-01

    Land and soil conservation topics, the final mandate of the United Convention to Combat desertification in drylands, have been diagnosed as still suffering from a lack of guidance. On the contrary, climate change and biodiversity issues -the other two big subjects of the Rio Conventions- seem to progress and may benefit from the advice of international panels. Arguably the weakness of policy measures and hence the application of scientific knowledge by land users and stakeholders could be the expression of an inadequate research organization and a lack of ability to channel their findings. In order to better understand the size, breadth and depth of the scientific communities involved in providing advice to this convention and to other bodies, this study explores the corpus of international publications dealing with land and/or with soils. A database of several thousands records including a significant part of the literature published so far was performed using the Web of Science and other socio-economic databases such as FRANCIS and CAIRN. We extracted hidden information using bibliometric methods and data mining applied to these scientific publications to map the key actors (laboratories, teams, institutions) involved in research on land and on soils. Several filters were applied to the databases in combination with the word "desertification". The further use of Tetralogie software merges databases, analyses similarities and differences between keywords, disciplines, authors and regions and identifies obvious clusters. Assessing their commonalities and differences, the visualisation of links and gaps between scientists, organisations, policymakers and other stakeholders is possible. The interpretation of the 'clouds' of disciplines, keywords, and techniques will enhance the understanding of interconnections between them; ultimately this will allow diagnosing some of their strengths and weaknesses. This may help explain why land and soil degradation remains a

  2. HIV research in Australia: linking basic research findings with clinical and public health outcomes

    PubMed Central

    Lewin, Sharon R; Kaldor, John M; Cooper, David A

    2006-01-01

    Despite a population of only 20 million and sustained low prevalence of HIV infection in Australia, Australian researchers have provided many substantial original findings to the fields of HIV pathogenesis, treatment and prevention. More recently, Australian clinicians and scientists have turned their attention to assisting other countries in developing effective responses, particularly within the Asia-Pacific region. It is therefore fitting that the 4th International AIDS Society (IAS) Conference on HIV Pathogenesis, Treatment and Prevention will be held in Sydney in July 2007. The meeting is expected to attract over 5000 participants and will have a dynamic and innovative programme within the three major themes of HIV basic science, clinical research and biomedical prevention. PMID:17140433

  3. Good Research and Faculty Buy-in: 2 Keys to Effective Marketing

    ERIC Educational Resources Information Center

    Blumenstyk, Goldie

    2008-01-01

    Effective marketing requires more than a sleek new logo. This article presents excerpts of an online discussion on the dos and don'ts of college marketing with Mary R. Stagaman, associate vice president for external relations at the University of Cincinnati. In this discussion, she noted that good research and faculty buy-in are the two keys to…

  4. Some Key Issues in Creativity Research and Evaluation as Seen from a Psychological Perspective

    ERIC Educational Resources Information Center

    Fryer, Marilyn

    2012-01-01

    This article explores a number of key issues with regard to the measurement of creativity in the course of conducting psychological research or when applying various evaluation measures. It is argued that, although creativity is a fuzzy concept, it is no more difficult to investigate than other fuzzy concepts people tend to take for granted. At…

  5. Building and Strengthening Policy Research Capacity: Key Issues in Canadian Higher Education

    ERIC Educational Resources Information Center

    Jones, Glen A.

    2014-01-01

    Given the importance of higher education in social and economic development, governments need to build a strong higher education data and policy research infrastructure to support informed decision-making, provide policy advice, and offer a critical assessment of key trends and issues. The author discusses the decline of higher education policy…

  6. Great lakes research--important human health findings and their impact on ATSDR's Superfund research program.

    PubMed

    Hicks, Heraline E; De Rosa, Christopher T

    2002-03-01

    The Agency for Toxic Substances and Disease Registry (ATSDR) was created by the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980, commonly known as Superfund. ATSDR is the principal United States federal public health agency involved with issues of public health and applied science concerning the human health impact of living in the vicinity of a hazardous waste site, or emergencies resulting from unplanned releases of hazardous substances into community environments. In pursuing these mandates, ATSDR's mission is to prevent exposure and adverse human health effects and diminished quality of life associated with exposure to hazardous substances from waste sites, unplanned releases, and other sources of pollution present in the environment. There are more than 2,000 toxic substances found at hazardous waste sites in the United States. ATSDR has developed a prioritized list of 275 substances that pose the greatest hazard to human health. In conducting its work ATSDR has identified data gaps in knowledge about the toxicity of various hazardous substances as well as gaps in human exposure characterization. As part of its mandate, ATSDR initiated a Substance-Specific Applied Research Program (SSARP) to address these data gaps. The ATSDR Great Lakes Human Health Effects Research Program (GLHHERP) is a congressionally-mandated research program that characterizes exposure to persistent toxic substances and investigates the potential for adverse health outcome in at-risk populations. The research findings from this program in the areas of exposure, sociodemographic data, and health effects have significant public health implications for ATSDR's Superfund research activities. PMID:12018016

  7. Researchers’ views on return of incidental genomic research results: qualitative and quantitative findings

    PubMed Central

    Klitzman, Robert; Appelbaum, Paul S.; Fyer, Abby; Martinez, Josue; Buquez, Brigitte; Wynn, Julia; Waldman, Cameron R.; Phelan, Jo; Parens, Erik; Chung, Wendy K.

    2013-01-01

    Purpose Comprehensive genomic analysis including exome and genome sequencing is increasingly being utilized in research studies, leading to the generation of incidental genetic findings. It is unclear how researchers plan to deal with incidental genetic findings. Methods We conducted a survey of the practices and attitudes of 234 members of the US genetic research community and performed qualitative semistructured interviews with 28 genomic researchers to understand their views and experiences with incidental genetic research findings. Results We found that 12% of the researchers had returned incidental genetic findings, and an additional 28% planned to do so. A large majority of researchers (95%) believe that incidental findings for highly penetrant disorders with immediate medical implications should be offered to research participants. However, there was no consensus on returning incidental results for other conditions varying in penetrance and medical actionability. Researchers raised concerns that the return of incidental findings would impose significant burdens on research and could potentially have deleterious effects on research participants if not performed well. Researchers identified assistance needed to enable effective, accurate return of incidental findings. Conclusion The majority of the researchers believe that research participants should have the option to receive at least some incidental genetic research results. PMID:23807616

  8. Findings of the US Research Needs Workshop on the Topic of Fusion Power

    SciTech Connect

    Meier, W R; Raffray, A R; Kurtz, R J; Morley, N B; Reiersen, W T; Sharpe, P; Willms, S

    2009-09-16

    The US Department of Energy, Office of Fusion Energy Sciences (OFES) conducted a Research Needs Workshop, referred to as ReNeW, in June 2009. The information developed at this workshop will help OFES develop a plan for US fusion research during the ITER era, roughly the next two decades. The workshop was organized in five Themes, one of which was Harnessing Fusion Power (or Fusion Power for short). The top level goal of the Fusion Power Theme was to identify the research needed to develop the knowledge to design and build, with high confidence, robust and reliable systems that can convert fusion products to useful forms of energy in a reactor environment, including a self-sufficient supply of tritium fuel. Each Theme was subsequently subdivided into Panels to address specific topics. The Fusion Power Panel topics were: fusion fuel cycle; power extraction; materials science; safety and environment; and reliability, availability, maintainability and inspectability (RAMI). Here we present the key findings of the Fusion Power Theme.

  9. 42 CFR 93.410 - Final HHS action with no settlement or finding of research misconduct.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Health and Human Services Research Misconduct Issues § 93.410 Final HHS action with no settlement or finding of research misconduct. When the final HHS action does not result in a settlement or finding of... 42 Public Health 1 2010-10-01 2010-10-01 false Final HHS action with no settlement or finding...

  10. YoungStar in Wisconsin: Analysis of Data as of July 2014. Executive Summary: Key Findings and Analysis

    ERIC Educational Resources Information Center

    Wisconsin Council on Children and Families, 2014

    2014-01-01

    YoungStar is a five-star quality rating system for child care providers based on education, learning environment, business methods, and practices around child health and well-being. Through this rating system, the state is addressing several key issues in Wisconsin's child care system. The rating system will: (1) Improve the overall quality of…