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Vanderbilt researchers find a protein family key to aging, cancer:

The list of aging-associated proteins known to be involved in cancer is growing longer, according to research by investigators at Vanderbilt-Ingram Cancer Center and the National Institutes of Health. The new study, published Oct. 17 in Cancer Cell, identifies the protein SIRT2 as a tumor suppressor linked to gender-specific tumor development in mice. Along with two other "sirtuin" proteins previously linked to cancer, the new finding suggests the existence of a rare "family" of tumor suppressors.


Alcoholics Anonymous: Key Research Findings from 2002–2007  

Microsoft Academic Search

Alcoholics Anonymous (AA) and other 12-step programs represent an affordable and widely accessible community-based resource for the estimated 18 million Americans with alcohol-related disorders. While substantiating information regarding 12-step programs remains challenging due to their autonomous structure and emphasis on anonymity, an ever increasing body of research provides a wealth of data regarding AA's efficacy, mechanisms of change, and viability

Shulamith Lala Ashenberg Straussner; Helga Byrne



Fox Chase researchers find a compound that targets a key mechanism behind lymphoma

Scientists at Fox Chase Cancer Center in Philadelphia have come one step closer to developing the first treatment to target a key pathway in lymphoma. The new findings were announced at the American Association for Cancer Research Annual Meeting 2012 on Tuesday, April 3.


Key Events and Lessons for Managers in a Diverse Workforce: A Report on Research and Findings.  

ERIC Educational Resources Information Center

The research documented in this report builds on earlier work in the 1980s in the area of on-the-job experiences in developing effective leaders. The current study was designed to answer the following: (1) What are the significant events from which African American managers learn and develop? (2) Are the key events and lessons learned different…

Douglas, Christina A.


Student Engagement and Student Outcomes: Key Findings from "CCSSE" Validation Research  

ERIC Educational Resources Information Center

The findings from 20 years of research on undergraduate education have been unequivocal: The more actively engaged students are--with college faculty and staff, with other students, and with the subject matter they study--the more likely they are to learn, to stick with their studies, and to attain their academic goals. The existing literature,…

McClenney, Kay; Marti, C. Nathan; Adkins, Courtney



Research in Online and Blended Learning in the Business Disciplines: Key Findings and Possible Future Directions  

ERIC Educational Resources Information Center

In this literature review, we examine and assess the state of research of online and blended learning in the business disciplines with the intent of assessing the state of the field and identifying opportunities for meaningful future research. We review research from business disciplines such as Accounting, Economics, Finance, Information Systems…

Arbaugh, J. B.; Godfrey, Michael R.; Johnson, Marianne; Pollack, Birgit Leisen; Niendorf, Bruce; Wresch, William



Washington University researchers find key genetic error in family of blood cancers:

Researchers used whole-genome sequencing to identify a critical mutation in some patients with myelodysplastic syndromes that appears to increase the likelihood they will develop acute myeloid leukemia.


Johns Hopkins researchers find key to lymph node metastasis in mice

In a study reported Sept. 10 in the Proceedings of the National Academy of Sciences Online Early Edition, researchers at Johns Hopkins describe their discovery of how a protein responsible for cell survival in low oxygen can trigger the spread of cancer cells into the lymphatic system in a mouse model of breast cancer. Johns Hopkins is home to the Sidney Kimmel Comprehensive Cancer Center.


The Relationship of Family Support to Family Outcomes: A Synthesis of Key Findings from Research on Severe Disability  

ERIC Educational Resources Information Center

There has been a gradual shift from a deficit to a support model for understanding disability over the last two decades. Although more attention is focused on supports at the individual level, policy has provided for the provision of family support. Despite this policy, families' needs for support are on the rise; and research suggests that…

Kyzar, Kathleen B.; Turnbull, Ann P.; Summers, Jean Ann; Gomez, Viviana Aya



Nanofluids Research: Key Issues  

PubMed Central

Nanofluids are a new class of fluids engineered by dispersing nanometer-size structures (particles, fibers, tubes, droplets) in base fluids. The very essence of nanofluids research and development is to enhance fluid macroscopic and megascale properties such as thermal conductivity through manipulating microscopic physics (structures, properties and activities). Therefore, the success of nanofluid technology depends very much on how well we can address issues like effective means of microscale manipulation, interplays among physics at different scales and optimization of microscale physics for the optimal megascale properties. In this work, we take heat-conduction nanofluids as examples to review methodologies available to effectively tackle these key but difficult problems and identify the future research needs as well. The reviewed techniques include nanofluids synthesis through liquid-phase chemical reactions in continuous-flow microfluidic microreactors, scaling-up by the volume averaging and constructal design with the constructal theory. The identified areas of future research contain microfluidic nanofluids, thermal waves and constructal nanofluids. PMID:20676214



Vermont's Changing Forests Key Findings on the  

E-print Network

1 Vermont's Changing Forests Key Findings on the Health of Forested Ecosystems from the Vermont Members Anne Archie, USDA Forest Service Douglas Lantagne, University of Vermont Ed O'Leary, Vermont, USDA Farm Service Agency Charles Scott, USDA Forest Service Steven Sinclair, Vermont Agency of Natural

Keeton, William S.


Institutional Data Management in Higher Education. ECAR Key Findings  

ERIC Educational Resources Information Center

This document presents the key findings from the 2009 ECAR (EDUCAUSE Center for Applied Research) study of institutional data management, which examines the policies and practices by which higher education institutions effectively collect, protect, and use digital information assets to meet academic and business needs. Importantly, it also…

Yanosky, Ronald



Key findings of the national weatherization evaluation  

SciTech Connect

In 1990, the U.S. Department of Energy sponsored a comprehensive evaluation of its Weatherization Assistance Program, the nation`s largest residential energy conservation program. The primary goal of the evaluation was to establish whether the Program meets the objectives of its enabling legislation and fulfills its mission statement, to reduce the heating and cooling costs for low-income families-particularly the elderly, persons with disabilities, and children by improving the energy-efficiency of their homes and ensuring their health and safety. Oak Ridge National Laboratory managed a five-part study which produced a series of documents evaluating the Program. The objective of this document is to summarize the findings of the five-part National Weatherization Evaluation. The five studies were as follows: (1) Network Study-this study characterized the weatherization network`s leveraging, capabilities, procedures, staff, technologies, and innovations; (2) Resources and Population Study-this study profiled low-income weatherization resources, the weatherized population, and the population remaining to be served; (3) Multifamily Study-this study described the nature and extent of weatherization activities in larger multifamily buildings; (4) Single-family Study-this study estimated the national savings and cost- effectiveness of weatherizing single-family and small multifamily dwellings that use natural gas or electricity for space heating; (5) Fuel-Oil Study-this study estimated the savings and cost-effectiveness of weatherizing single-family homes, located in nine northeastern states, that use fuel oil for space heating. This paper provides a brief overview of each study`s purposes, research methods and most important findings.

Brown, M.A.; Berry, L.G.



Breast Cancer Research Finding Answers. Finding Cures.  

E-print Network

Breast Cancer Research Finding Answers. Finding Cures. Thanks to improvements in treatment and early detection, more and more women are surviving breast cancer. In fact, the five-year survival rate for women with breast cancer today is 90%, up from only 63% in the 1960s. While progress has clearly been

Kowalczykowski, Stephen C.


Perceptual Tests of an Algorithm for Musical Key-Finding  

Microsoft Academic Search

Perceiving the tonality of a musical passage is a fundamental aspect of the experience of hearing music. Models for determining tonality have thus occupied a central place in music cognition research. Three experiments investigated 1 well-known model of tonal determination: the Krumhansl-Schmuckler key-finding algorithm. In Experiment 1, listeners' percepts of tonality following short musical fragments derived from preludes by Bach

Mark A. Schmuckler; Robert Tomovski



Knowledge translation of research findings  

PubMed Central

Background One of the most consistent findings from clinical and health services research is the failure to translate research into practice and policy. As a result of these evidence-practice and policy gaps, patients fail to benefit optimally from advances in healthcare and are exposed to unnecessary risks of iatrogenic harms, and healthcare systems are exposed to unnecessary expenditure resulting in significant opportunity costs. Over the last decade, there has been increasing international policy and research attention on how to reduce the evidence-practice and policy gap. In this paper, we summarise the current concepts and evidence to guide knowledge translation activities, defined as T2 research (the translation of new clinical knowledge into improved health). We structure the article around five key questions: what should be transferred; to whom should research knowledge be transferred; by whom should research knowledge be transferred; how should research knowledge be transferred; and, with what effect should research knowledge be transferred? Discussion We suggest that the basic unit of knowledge translation should usually be up-to-date systematic reviews or other syntheses of research findings. Knowledge translators need to identify the key messages for different target audiences and to fashion these in language and knowledge translation products that are easily assimilated by different audiences. The relative importance of knowledge translation to different target audiences will vary by the type of research and appropriate endpoints of knowledge translation may vary across different stakeholder groups. There are a large number of planned knowledge translation models, derived from different disciplinary, contextual (i.e., setting), and target audience viewpoints. Most of these suggest that planned knowledge translation for healthcare professionals and consumers is more likely to be successful if the choice of knowledge translation strategy is informed by an assessment of the likely barriers and facilitators. Although our evidence on the likely effectiveness of different strategies to overcome specific barriers remains incomplete, there is a range of informative systematic reviews of interventions aimed at healthcare professionals and consumers (i.e., patients, family members, and informal carers) and of factors important to research use by policy makers. Summary There is a substantial (if incomplete) evidence base to guide choice of knowledge translation activities targeting healthcare professionals and consumers. The evidence base on the effects of different knowledge translation approaches targeting healthcare policy makers and senior managers is much weaker but there are a profusion of innovative approaches that warrant further evaluation. PMID:22651257



Public key infrastructure for DOE security research  

SciTech Connect

This document summarizes the Department of Energy`s Second Joint Energy Research/Defence Programs Security Research Workshop. The workshop, built on the results of the first Joint Workshop which reviewed security requirements represented in a range of mission-critical ER and DP applications, discussed commonalties and differences in ER/DP requirements and approaches, and identified an integrated common set of security research priorities. One significant conclusion of the first workshop was that progress in a broad spectrum of DOE-relevant security problems and applications could best be addressed through public-key cryptography based systems, and therefore depended upon the existence of a robust, broadly deployed public-key infrastructure. Hence, public-key infrastructure ({open_quotes}PKI{close_quotes}) was adopted as a primary focus for the second workshop. The Second Joint Workshop covered a range of DOE security research and deployment efforts, as well as summaries of the state of the art in various areas relating to public-key technologies. Key findings were that a broad range of DOE applications can benefit from security architectures and technologies built on a robust, flexible, widely deployed public-key infrastructure; that there exists a collection of specific requirements for missing or undeveloped PKI functionality, together with a preliminary assessment of how these requirements can be met; that, while commercial developments can be expected to provide many relevant security technologies, there are important capabilities that commercial developments will not address, due to the unique scale, performance, diversity, distributed nature, and sensitivity of DOE applications; that DOE should encourage and support research activities intended to increase understanding of security technology requirements, and to develop critical components not forthcoming from other sources in a timely manner.

Aiken, R.; Foster, I.; Johnston, W.E. [and others



DCCPS: Behavioral Research Program: Key Initiatives

Skip Navigation Twitter Multimedia Home About Key Initiatives Funding & Grants Resources Tools Cancer Control & Population Sciences Home Behavioral Research Program Home Key Initiatives Cognitive, Affective, and Social Processes in Health Research Workgroup


DCCPS: Behavioral Research Program: Key Initiatives

Skip Navigation Twitter Multimedia Home About Key Initiatives Funding Tools Resources Cancer Control & Population Sciences Home Behavioral Research Program Home BRP Key Initiatives: CASPHR The Cognitive, Affective, and Social Processes in Health Research


Human Health Effects of Dichloromethane: Key Findings and Scientific Issues  

PubMed Central

Background: The U.S. EPA’s Integrated Risk Information System (IRIS) completed an updated toxicological review of dichloromethane in November 2011. Objectives: In this commentary we summarize key results and issues of this review, including exposure sources, identification of potential health effects, and updated physiologically based pharmacokinetic (PBPK) modeling. Methods: We performed a comprehensive review of primary research studies and evaluation of PBPK models. Discussion: Hepatotoxicity was observed in oral and inhalation exposure studies in several studies in animals; neurological effects were also identified as a potential area of concern. Dichloromethane was classified as likely to be carcinogenic in humans based primarily on evidence of carcinogenicity at two sites (liver and lung) in male and female B6C3F1 mice (inhalation exposure) and at one site (liver) in male B6C3F1 mice (drinking-water exposure). Recent epidemiologic studies of dichloromethane (seven studies of hematopoietic cancers published since 2000) provide additional data raising concerns about associations with non-Hodgkin lymphoma and multiple myeloma. Although there are gaps in the database for dichloromethane genotoxicity (i.e., DNA adduct formation and gene mutations in target tissues in vivo), the positive DNA damage assays correlated with tissue and/or species availability of functional glutathione S-transferase (GST) metabolic activity, the key activation pathway for dichloromethane-induced cancer. Innovations in the IRIS assessment include estimation of cancer risk specifically for a presumed sensitive genotype (GST-theta-1+/+), and PBPK modeling accounting for human physiological distributions based on the expected distribution for all individuals 6 months to 80 years of age. Conclusion: The 2011 IRIS assessment of dichloromethane provides insights into the toxicity of a commonly used solvent. Citation: Schlosser PM, Bale AS, Gibbons CF, Wilkins A, Cooper GS. 2015. Human health effects of dichloromethane: key findings and scientific issues. Environ Health Perspect 123:114–119; PMID:25325283

Schlosser, Paul M.; Bale, Ambuja S.; Gibbons, Catherine F.; Wilkins, Amina



Teacher Retirement Systems: Research Findings. Research Brief  

ERIC Educational Resources Information Center

This policy brief summarizes findings presented at a February 2009 research conference on teacher retirement systems hosted by the National Center on Performance Incentives (NCPI) at Vanderbilt University's Peabody College. The 2009 conference was the second in a series of NCPI events focusing on findings from recent research on issues related to…

Hansen, Janet S.; Podgursky, Michael J.; Costrell, Robert M.



Unlocking the Key to Undergraduate Research  

E-print Network

Unlocking the Key to Undergraduate Research Kimberly Hutchinson Undergraduate Research with graduate students! Increase your ability to do well in Graduate School! Why Do Undergraduate ResearchWhy Do Undergraduate Research?? #12;Why Do Undergraduate ResearchWhy Do Undergraduate Research ?? Continued

Romano, Raquel


STAFF TRAVEL SURVEY 2006 KEY FINDINGS Survey introduction  

E-print Network

completed either an online or hard copy survey ­ a 34% response rate. A Staff Travel Survey was previously1 STAFF TRAVEL SURVEY 2006 ­ KEY FINDINGS Survey introduction The Staff Travel Survey 2006 was launched on 13th January and ran for 3 weeks. Links to an online survey form were provided via the Friday

Brierley, Andrew


University of St Andrews Student Travel Survey 2009 -Key Findings  

E-print Network

University of St Andrews 1 Student Travel Survey 2009 - Key Findings 1 Introduction 1.1 Introduction During November 2009 students were asked to take part in the University of St Andrews Travel Survey. Links to an online survey were distributed electronically using the internal email system

Brierley, Andrew


Staff Travel Survey 2012/13 Key Findings Introduction  

E-print Network

travel patterns and behaviours. Links to an online survey (hosted by Bristol Online Surveys) were1 Staff Travel Survey 2012/13 ­ Key Findings Introduction Between November 2012 and April 2013 staff were asked to take part in the University of St Andrews Staff Travel Survey. The travel survey has

Brierley, Andrew


Effective radiology dashboards: key research findings.  


Innovative organizations have access to information for business intelligence through the objectives displayed in dashboards. In healthcare organizations, where the goal is to improve quality of care along with reducing costs, the radiology department is important from both financial and clinical aspects. Therefore, how to manage this department has critical impact on the effectiveness and efficiency of the organization. Today, since the information in this department not only has different data structure but also is gathered from different data sources, a well defined, comprehensive dashboard can be an effective tool to enhance performance. PMID:23638580

Karami, Mahtab; Safdari, Reza; Rahimi, Azin



Human Health Effects of Tetrachloroethylene: Key Findings and Scientific Issues  

PubMed Central

Background: The U.S. Environmental Protection Agency (EPA) completed a toxicological review of tetrachloroethylene (perchloroethylene, PCE) in February 2012 in support of the Integrated Risk Information System (IRIS). Objectives: We reviewed key findings and scientific issues regarding the human health effects of PCE described in the U.S. EPA’s Toxicological Review of Tetrachloroethylene (Perchloroethylene). Methods: The updated assessment of PCE synthesized and characterized a substantial database of epidemiological, experimental animal, and mechanistic studies. Key scientific issues were addressed through modeling of PCE toxicokinetics, synthesis of evidence from neurological studies, and analyses of toxicokinetic, mechanistic, and other factors (tumor latency, severity, and background rate) in interpreting experimental animal cancer findings. Considerations in evaluating epidemiological studies included the quality (e.g., specificity) of the exposure assessment methods and other essential design features, and the potential for alternative explanations for observed associations (e.g., bias or confounding). Discussion: Toxicokinetic modeling aided in characterizing the complex metabolism and multiple metabolites that contribute to PCE toxicity. The exposure assessment approach—a key evaluation factor for epidemiological studies of bladder cancer, non-Hodgkin lymphoma, and multiple myeloma—provided suggestive evidence of carcinogenicity. Bioassay data provided conclusive evidence of carcinogenicity in experimental animals. Neurotoxicity was identified as a sensitive noncancer health effect, occurring at low exposures: a conclusion supported by multiple studies. Evidence was integrated from human, experimental animal, and mechanistic data sets in assessing adverse health effects of PCE. Conclusions: PCE is likely to be carcinogenic to humans. Neurotoxicity is a sensitive adverse health effect of PCE. Citation: Guyton KZ, Hogan KA, Scott CS, Cooper GS, Bale AS, Kopylev L, Barone S Jr, Makris SL, Glenn B, Subramaniam RP, Gwinn MR, Dzubow RC, Chiu WA. 2014. Human health effects of tetrachloroethylene: key findings and scientific issues. Environ Health Perspect 122:325–334;? PMID:24531164

Hogan, Karen A.; Scott, Cheryl Siegel; Cooper, Glinda S.; Bale, Ambuja S.; Kopylev, Leonid; Barone, Stanley; Makris, Susan L.; Glenn, Barbara; Subramaniam, Ravi P.; Gwinn, Maureen R.; Dzubow, Rebecca C.; Chiu, Weihsueh A.



Air Research Program: Key Pathways research track  

EPA Science Inventory

The pathways research track applies animal, cellular, and human studies to discern whether there is a common molecular mechanism (e.g. production of oxidative stress, phosphatase inhibition, disruption of iron homeostasis) through which air pollutants induce toxicity of air pollu...


The Benefits of Undergraduate Research Finding a Faculty Sponsor  

E-print Network

The Benefits of Undergraduate Research And Finding a Faculty Sponsor Why do undergraduate research? Participating in an undergraduate research experience will provide you with many benefits. These include: Hands Establishing a good working relationship with a faculty member is a key element in a successful research

Weinberger, Hans


Alternative IT Sourcing Strategies: From the Campus to the Cloud. ECAR Key Findings  

ERIC Educational Resources Information Center

This document presents the key findings from the 2009 ECAR (EDUCAUSE Center for Applied Research) study, "Alternative IT Sourcing Strategies: From the Campus to the Cloud," by Philip J. Goldstein. The study explores a multitude of strategies used by colleges and university information technology organizations to deliver the breadth of technologies…

Goldstein, Philip J.



The ECAR Study of Undergraduate Students and Information Technology, 2010. Key Findings  

ERIC Educational Resources Information Center

This document presents the key findings from "The ECAR Study of Undergraduate Students and Information Technology, 2010". Since 2004, the annual ECAR (EDUCAUSE Center for Applied Research) study of undergraduate students and information technology has sought to shed light on how information technology affects the college experience. We ask…

Smith, Shannon D.; Caruso, Judith Borreson



Rangeland ecology: Key global research issues & questions  

E-print Network

1 Rangeland ecology: Key global research issues & questions Robin Reid1 and Maria Fernandez Ecology Lab 2Associate Professor Colorado State University, Fort Collins, Colorado, USA Global Issues and Questions in Rangeland Ecology · Despite the focus here on global issues, we need to recognize that Mongolia


Rangeland ecology: Key global research issues & questions  

E-print Network

1 Rangeland ecology: Key global research issues & questions Robin Reid and Maria Fernandez-Gimenez This paper discusses developments in our understanding about rangeland ecology and rangeland dynamics in the last 20 years. Before the late 1980's, the mainstream view in range ecology was that livestock


78 FR 79460 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013, 2014

...the Secretary Findings of Research Misconduct AGENCY: Office...given that the Office of Research Integrity (ORI) has taken...Hospital, Third Military Medical University, Chonqing, China, engaged in research misconduct in research...



76 FR 68460 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013, 2014

...Secretary Findings of Research Misconduct AGENCY...that the Office of Research Integrity (ORI...University of Virginia Medical Center: Based on...Resident Physician at UVA Medical Center, engaged in research misconduct by...



Editorial Decisions May Perpetuate Belief in Invalid Research Findings  

PubMed Central

Social psychology and related disciplines are seeing a resurgence of interest in replication, as well as actual replication efforts. But prior work suggests that even a clear demonstration that a finding is invalid often fails to shake acceptance of the finding. This threatens the full impact of these replication efforts. Here we show that the actions of two key players – journal editors and the authors of original (invalidated) research findings – are critical to the broader public’s continued belief in an invalidated research conclusion. Across three experiments, we show that belief in an invalidated finding falls sharply when a critical failed replication is published in the same – versus different – journal as the original finding, and when the authors of the original finding acknowledge that the new findings invalidate their conclusions. We conclude by discussing policy implications of our key findings. PMID:24023863

Eriksson, Kimmo; Simpson, Brent



Space Situational Awareness (SSA) research findings  

NASA Astrophysics Data System (ADS)

Space Situational Awareness (SSA) is the foundation for space superiority and has become a national priority. Providing full SSA requires knowledge of space and ground assets along with communication links between these assets. It also requires an understanding of potential events and threats that may affect these assets. This paper summarizes the findings resulting from a research environment established to explore SSA issues. Non-traditional data sources available on the internet are identified along with methods to mine relevant data. Algorithms to augment this data with value added processing were evaluated and key features are presented. These include all-on-all conjunction analysis utilizing analytical distributed processing approaches and maneuver detection utilizing an approach described in the AMOS 2007 paper "Satellite Maneuver Detection Using Two-line Elements". Data fusion techniques are presented which were utilized to evaluate space launches, enhance maneuver detection capabilities, characterize events and determine possible intent. Several visualization approaches were explored and the key features/limitations are discussed to include performance consideration, event models between visualization components, and data needs at the tactical, operational, and strategic levels. Data dissemination approaches utilizing a Service Oriented Architecture (SOA) are highlighted along with challenges such as Multiple Levels of Security associated with the data. Dependencies between visualization and dissemination that impact the system's performance are discussed. Alternatives to balance system performance and application of a User Defined Operational Picture (UDOP) are explored.

Richmond, D.


Intradistrict Resource Allocation: Key Findings and Policy Implications  

ERIC Educational Resources Information Center

The focus on school-level performance brought about by the No Child Left Behind Act--as well as recent court cases challenging the use of race in student assignment policies--has brought greater attention to the need to for careful study of the allocation of resources within school districts. This paper describes the policy context, reviews key

Houck, Eric A.



76 FR 23599 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013, 2014 hereby given that the Office of Research Integrity (ORI) has taken final...Bhrigu, PhD, University of Michigan Medical School: Based on the findings of...analysis conducted by the Office of Research Integrity (ORI) during its...



Key Diagnostic Finding in a Condition with Variable Clinical Presentations  

PubMed Central

This is an interesting case series on a very common genetic condition which are often diagnosed late as clinical signs are inconspicuous. We would like to highlight the principal clinical examination finding which led to diagnosis. PMID:23984150

Sukumaran, Anju; Buchlis, John



Hewlett Leaders in Student Success: Program Overview and Key Findings  

ERIC Educational Resources Information Center

In 2008 and 2009, the Research and Planning Group for California Community Colleges (RP Group) worked closely with the Hewlett Foundation to focus attention on excellent work in basic skills education at California's community colleges. Hewlett Leaders in Student Success highlighted innovations by front-runners in California in order to help…

Miller, Margaret



Final Boundary Layer Research and Findings Report Draft Boundary Layer Research and Findings Report  

E-print Network

IV Final Boundary Layer Research and Findings Report #12;Draft Boundary Layer Research and Findings Cases Associated with Boundary Layer Model Problems ............. 6 1.1 Problems Related to Atmospheric ......................................................... 9 2.1.3 Boundary Layer Formulation Factors


Prejudice Reduction and the Findings of Research.  

ERIC Educational Resources Information Center

Research studies that have investigated the effects of interventions aimed at reducing prejudice are reviewed, and a synthesis of their findings is presented. Some generalizations are offered that have the potential to lead towards a less prejudiced society. Research is summarized according to the intervention approaches used in the following…

Pate, Glenn S.


Applications of classroom management research findings  

Microsoft Academic Search

The purpose of this study was to examine the long?term effects of providing a research?based approach to classroom management through a two?phase staff development process. Findings indicate that teachers identified specific benefits they gained from implementing group development and cooperative learning strategies. The findings also indicate that classrooms of high implementors differed from classrooms of low implementors. Finally, specific characteristics

Joyce G. Putnam



National Opinion Research Center: Data and Findings  

NSDL National Science Digital Library

The National Opinion Research Center (NORC) was created in 1941 with a mission "to conduct high-quality social science research in the public interest." Its work is quite broad and includes studies of public school system performance, economic development projects, and other germane matters. On the Data and Findings page, visitors can peruse and explore hundreds of NORC's papers from past months and years. Interested parties can search through all of these documents as they see fit or perhaps just scroll through to find something that strikes some interest. Some recent titles include "Promising Practices to Improve Access to Oral Health Care in Rural Communities" and "The State of Our Nation's Youth."


Researchers Find Genetic Response to Global Warming  

NSDL National Science Digital Library

University of Alberta biologist Stan Boutin and his research team have recently published findings that North American red squirrels exhibit genetic changes in response to a warming climate. This Web site contains a University of Alberta press release detailing this first-ever demonstration of genetic adaptation to global warming. With implications that extend far beyond the immediate research concerns of geneticists and environmental scientists, Boutin's work as presented in this Web site should be interesting to wide audience.

Dey, Phoebe.


Space Situational Awareness (SSA) research findings  

Microsoft Academic Search

Space Situational Awareness (SSA) is the foundation for space superiority and has become a national priority. Providing full SSA requires knowledge of space and ground assets along with communication links between these assets. It also requires an understanding of potential events and threats that may affect these assets. This paper summarizes the findings resulting from a research environment established to

David Richmond; Valley Forge PA



DCCPS: Behavioral Research Program: Key Initiatives

Research Interests Alexander Rothman, PhD, is a professor in the Department of Psychology and the Associate Dean for Research and Graduate Programs, College of Liberal Arts at the University of Minnesota.


DCCPS: Behavioral Research Program: Key Initiatives

Project Background This supplement was sponsored by the National Cancer Institute’s (NCI) Behavioral Research Program, in the Division of Cancer Control and Population Sciences and the Office of Behavioral and Social Sciences Research.


DCCPS: Behavioral Research Program: Key Initiatives

Group Origin A fundamental goal of the National Cancer Institute’s Behavioral Research Program (BRP) is to facilitate a better understanding of health behaviors and their underlying processes. The Cognitive, Affective, and Social Processes in Health Research (CASPHR) working group was convened in Fall 2009 to provide expert consultation on how theories of cognitive, affective, and social processes, in particular, can enhance research and practice throughout the cancer continuum.


Key Findings from a National Internet Survey of 400 Teachers and 95 Principals Conducted November 12-21, 2008  

ERIC Educational Resources Information Center

This paper presents the key findings from a national Internet survey of 400 teachers and 95 principals. This survey was conducted November 12-21, 2008. The sample was based on a list provided by EMI Surveys, a custom online research sample provider with an extensive portfolio of projects. The margin of error for a sample of 495 interviews is [plus…

McCleskey, Nicole



DCCPS: Behavioral Research Program: Key Initiatives

William Klein, PhD, was appointed associate director of the Behavioral Research Program (BRP) in August 2009. Prior to this appointment, he was associate professor in the Psychology Department at the University of Pittsburgh.


Clinical Trials: A Crucial Key to Human Health Research  


... Past Issues Clinical Trials: A Crucial Key to Human Health Research Past Issues / Summer 2006 Table of ... Javascript on. Photo: PhotoDisc At the forefront of human health research today are clinical trials—studies that ...


DCCPS: Behavioral Research Program: Key Initiatives

Research Interests Dr. Bryan received her BA in Psychology from UCLA, and her MA and PhD in Social Psychology with a Quantitative Emphasis from Arizona State University. Dr. Bryan is currently Professor and Director of the Social Psychology PhD Program in the Department of Psychology and Neuroscience at the University of Colorado Boulder.


DCCPS: Behavioral Research Program: Key Initiatives

There is growing attention within cancer survivorship research on neuropsychological effects (i.e., deficits in executive functioning, memory) associated with cancer and cancer therapies and their role in quality of life. However, the impact of cancer and related therapy on social cognitive processes, and the connection of these social cognitive processes to neuropsychological impairment and ultimately quality of life remain comparatively under-explored.


DCCPS: Behavioral Research Program: Key Initiatives

The Science of Research and Technology Branch (SRTB) is invested in the improvement of the scientific rigor with which health behavior theories are tested and applied. SRTB encourages and supports the use of new data sources and methods for theory testing. Information about behavior and its influences from both prospective and archival collection methods is increasingly more temporally dense and “big” (i.e., high in volume, variety, and velocity).


Researchers Find Japanese Submarine at Pearl Harbor  

NSDL National Science Digital Library

Earlier this week, researchers from the University of Hawaii and the Hawaii Underwater Research Lab located the remains of a Japanese midget submarine. Found in 1200 feet of water, the submarine was sunk by the USS Ward just an hour before the aerial attack on Pearl Harbor on December 7, 1941. Most important, the discovery of the midget submarine offers concrete physical evidence that the United States did fire the first shot against the Japanese. Previous expeditions to locate the sub, including an effort made in 2000 by the National Geographic Society, had been unsuccessful, largely due to the fact that the area is a military "junkyard" with tons of debris on the ocean floor.For more in-depth information on this story, readers may find the first four news links particularly helpful. The fifth link leads to the Hawaii Underwater Research Lab's Web site that features photographs of the midget sub from the expedition earlier this week. The sixth link is to a Web site dealing with the history and missions of the USS Ward. The final link contains detailed information about the 2000 expedition led by Robert Ballard, with support from the National Geographic Society, to find the midget submarine.

Green, Marcia.



Research on Key Technologies of Cloud Computing  

NASA Astrophysics Data System (ADS)

With the development of multi-core processors, virtualization, distributed storage, broadband Internet and automatic management, a new type of computing mode named cloud computing is produced. It distributes computation task on the resource pool which consists of massive computers, so the application systems can obtain the computing power, the storage space and software service according to its demand. It can concentrate all the computing resources and manage them automatically by the software without intervene. This makes application offers not to annoy for tedious details and more absorbed in his business. It will be advantageous to innovation and reduce cost. It's the ultimate goal of cloud computing to provide calculation, services and applications as a public facility for the public, So that people can use the computer resources just like using water, electricity, gas and telephone. Currently, the understanding of cloud computing is developing and changing constantly, cloud computing still has no unanimous definition. This paper describes three main service forms of cloud computing: SAAS, PAAS, IAAS, compared the definition of cloud computing which is given by Google, Amazon, IBM and other companies, summarized the basic characteristics of cloud computing, and emphasized on the key technologies such as data storage, data management, virtualization and programming model.

Zhang, Shufen; Yan, Hongcan; Chen, Xuebin


77 FR 52034 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013, 2014

...that the Office of Research Integrity (ORI...Developmental and Stem Cell Biology, Joslin, engaged in research misconduct in research...Respondent engaged in research misconduct involving...rejuventation of blood stem cell niches.''...



77 FR 40059 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013, 2014

...research misconduct in research supported by National...Oversight, Office of Research Integrity, 1101 Wootton...Respondent engaged in research misconduct by falsifying...with human embryonic stem cells (hESCs) to...



Monitoring the Future: National Results on Adolescent Drug Use. Overview of Key Findings, 2002.  

ERIC Educational Resources Information Center

This report presents an overview of the key findings from the Monitoring the Future 2002 nationwide survey of 8th, 10th, and 12th grade students. A particular emphasis is placed on recent trends in the use of licit and illicit drugs. Trends in the levels of perceived risk and personal disapproval associated with each drug--which this study has…

Michigan Univ., Ann Arbor. Inst. for Social Research.


Monitoring the Future National Results on Adolescent Drug Use: Overview of Key Findings, 2001.  

ERIC Educational Resources Information Center

This report presents an overview of the key findings from the Monitoring the Future 2001 nationwide survey of 8th, 10th, and 12th grade students. A particular emphasis is placed on recent trends in the use of licit and illicit drugs. Trends in the levels of perceived risk and personal disapproval associated with each drug--which this study has…

Johnston, Lloyd D.; O'Malley, Patrick M.; Bachman, Jerald G.


Finding Market Research on the Web Copyright 2001  

E-print Network

Finding Market Research on the Web Copyright © 2001 MarketResearch of market research firms. These are publishers that study and produce reports on consumer, industrial in between. But there is a certain segment of market #12;Finding Market Research on the Web MarketResearch

Haykin, Simon


Participatory Action Research with Older Adults: Key Principles in Practice  

ERIC Educational Resources Information Center

Purpose: Although participatory action research (PAR) is increasingly viewed as an important complement to traditional investigator-driven research, relatively little PAR has taken place in which older adults have been prominent partners. This article provides a review of the literature on PAR in gerontology, highlighting key studies and their…

Blair, Thomas; Minkler, Meredith



77 FR 22320 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013, 2014

...given that the Office of Research Integrity (ORI) has...Institute, OHSU, engaged in research misconduct in research reported in two grant...pigment epithelial (RPE) cells obtained from Rhesus monkey embryonic stem cells (ECS) into a...



75 FR 77641 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013, 2014

...Medicine (NYUSOM) and the Office of Research Integrity (ORI) found that Sagar...Biomedical Sciences at NYUSOM, engaged in research misconduct in research supported by National Institute of General Medical Sciences (NIGMS), National...



77 FR 124 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013, 2014

...given that the Office of Research Integrity (ORI) has...of New York, Upstate Medical University: Based on...SUNY US, engaged in research misconduct in research supported by National Institute of General Medical Sciences...



Animal Research: Finding Cures, Saving Lives  

NSDL National Science Digital Library

This website provides an online and a printable brochure that provides information on why researchers study animals, how research animals are cared for, the ethics of animal research, cosmetic testing on animals, and how animal research helps people in the context of a diabetes patient.



Russian research capabilities: Findings of site visits  

SciTech Connect

In June 1993, a proposal was presented to the International Environmental Institute (IEI) in Kennewick, Washington, to establish cooperation and coordination to further pursue the interests of the United States of America and the Republic of Russia in the application and promotion of environmental technology; characterization, treatment, handling, isolation, and disposal of hazardous and radioactive materials; conversion of defense sites to other purposes; and technology transfer, cooperative programs, joint technology development and contractual research. In response to this proposal, IEI and Pacific Northwest Laboratory (PNL) jointly provided funding to send Dr. Dennis W. Wester on a fact-finding mission to Novosibirsk, Moscow, and St. Petersburg, Russia. The trip covered a period of eight weeks, six of which were spent in Novosibirsk and adjoining or related cities and one of which was spent in each of Moscow and St. Petersburg. The general objectives of the trip were to establish a basis for cooperation between IEI and the Russian Academy of Sciences (RAS) for future coordination of mutual interests and objectives such as technology acquisition, development, demonstration, application, and commercialization; use of capabilities and assets developed by the U.S. Department of Energy (DOE) and the RAS; and expediting of cooperative agreements, personnel exchanges, joint ventures and other contractual relationships. The particular objectives of this trip were to evaluate the capabilities of the RAS to satisfy the technology needs associated with the cleanup of the Hanford Site and similar sites in the U.S. and to evaluate the expediency of establishing an IEI presence in Russia.

Wester, D.W.



77 FR 5254 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013, 2014

...DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary Findings...National Institute of Child Health and Human Development (NICHD), National Institutes...Respondent's intentionally deceptive behavior, including false statements made to...



77 FR 76491 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013, 2014

...redone. Specifically, ORI finds that Respondent: Falsified Powerpoint slides and spreadsheets for histomorphometric and microCT results by using the values of HS1 knockout (KO) mice and their controls to represent the CathepsinK cre- Cortactin KO...



Online Shopping Behavior: Key Dimensions and Research Synthesis  

Microsoft Academic Search

A growing body of research has emerged related to the online shopping. In this study, the current literature related to media factors that influence online shopping behavior is extensively surveyed by identifying key dimensions. Four dimensions of the online shopping channel, including informativeness, convenience, customer service, and experiential uniqueness, are proposed based on the literature review and expert judgments. In

Dong Shen; Craig A. Kelley; Joseph Richards; Claudia Bridges



76 FR 7568 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013, 2014

...or that submits a report of PHS-funded research...for PHS funds, or report, manuscript, or abstract involving PHS-funded...are based on actual experiments or are otherwise legitimately...the application or report; and (3) To...



78 FR 5454 - Findings of Research Misconduct  

Federal Register 2010, 2011, 2012, 2013, 2014

...conducted by ORI in its oversight review, ORI found that Dr. Rao M. Adibhatla, Assistant Professor, Department of Neurological Surgery, UW, engaged in research misconduct by falsifying results in two publications supported by National Institute of...



Animal Research: Finding Cures, Saving Lives  

NSDL National Science Digital Library

The U.S. Public Health Service acknowledges that "virtually every medical achievement of the last century has depended directly or indirectly on research with animals." Created by the American Physiological Society, this website helps students learn about and explore the ethics and particulars of animal research. It answers common questions in a straight-forward and accessible manner. It also includes links to other resources to aid in a deeper exploration of the subject.

The American Physiological Society


Community-based partnership to identify keys to biospecimen research participation.  


Reported barriers to participation in biospecimen banking include unwillingness to undergo blood-draw procedures and concerns about confidentiality breaches, privacy, and discrimination. The study identified key factors and influential perspectives to address these barriers and inform methods to improve recruitment and research participation among racially diverse community. A mixed-methods, community-based participatory research orientation was used to collect formative findings to develop a pilot intervention. Methods included nine key informant interviews, three focus groups (n?=?26), and 64 community surveys. Findings showed: (1) increased concern of exploitation by pharmaceutical company sponsor; (2) varied perceptions about monetary compensation for research participation; and (3) willingness to participate in a biospecimen banking study by more than 30% of the people in the community survey. Research participation and biospecimen donation may be influenced by who is sponsoring a study. Monetary incentives for study participation may be more important for African American than White participants. PMID:23055133

Erwin, Deborah O; Moysich, Kirsten; Kiviniemi, Marc T; Saad-Harfouche, Frances G; Davis, Warren; Clark-Hargrave, Nikia; Ciupak, Gregory L; Ambrosone, Christine B; Walker, Charles



Research Results Ultra-fast Energy Transfer from Monomer to Dimer within a Trimeric Molecule New Progress in Heterogeneous Catalysis Research Key Progress in Research on Terrestrial Carbon Cycle in China A New Progress in Research on the Mechanism of Bio-Invasion New Findings in Anti-viral infection and Control of Inflammation Major Headway in Avian Origin Research New Progress in Gold-Nanoparticle-Based Biochips Topological Insulator Research Made Important Progress Major Progress in Biodiversity Achieved New Developments of Direct Methods in Protein Crystallography Major Progress in China-UK Collaboration on the Causal Relationship between Volcanic Activity and Biological Distinction News in Brief: NSFC set up "Research Fund for Young Foreign Scholars" How Often Does Human DNA Mutate? Research Progress on Colossal Anisotropic Magneto Resistive Effect  

NASA Astrophysics Data System (ADS)

Ultra-fast Energy Transfer from Monomer to Dimer within a Trimeric Molecule New Progress in Heterogeneous Catalysis Research Key Progress in Research on Terrestrial Carbon Cycle in China A New Progress in Research on the Mechanism of Bio-Invasion New Findings in Anti-viral infection and Control of Inflammation Major Headway in Avian Origin Research New Progress in Gold-Nanoparticle-Based Biochips Topological Insulator Research Made Important Progress Major Progress in Biodiversity Achieved New Developments of Direct Methods in Protein Crystallography Major Progress in China-UK Collaboration on the Causal Relationship between Volcanic Activity and Biological Distinction News in Brief: NSFC set up "Research Fund for Young Foreign Scholars" How Often Does Human DNA Mutate? Research Progress on Colossal Anisotropic Magneto Resistive Effect



40 CFR 63.1176 - Where can I find definitions of key words used in this subpart?  

Code of Federal Regulations, 2013 CFR

... 11 2013-07-01 2013-07-01 false Where can I find definitions of key words used in this subpart? 63.1176...Pollutants for Mineral Wool Production § 63.1176 Where can I find definitions of key words used in this subpart? The...



40 CFR 63.1176 - Where can I find definitions of key words used in this subpart?  

Code of Federal Regulations, 2014 CFR

... 11 2014-07-01 2014-07-01 false Where can I find definitions of key words used in this subpart? 63.1176...Pollutants for Mineral Wool Production § 63.1176 Where can I find definitions of key words used in this subpart? The...



40 CFR 63.1176 - Where can I find definitions of key words used in this subpart?  

Code of Federal Regulations, 2011 CFR

... 10 2011-07-01 2011-07-01 false Where can I find definitions of key words used in this subpart? 63.1176...Pollutants for Mineral Wool Production § 63.1176 Where can I find definitions of key words used in this subpart? The...



40 CFR 63.1176 - Where can I find definitions of key words used in this subpart?  

Code of Federal Regulations, 2010 CFR

... 10 2010-07-01 2010-07-01 false Where can I find definitions of key words used in this subpart? 63.1176...Pollutants for Mineral Wool Production § 63.1176 Where can I find definitions of key words used in this subpart? The...



40 CFR 63.1176 - Where can I find definitions of key words used in this subpart?  

Code of Federal Regulations, 2012 CFR

... 11 2012-07-01 2012-07-01 false Where can I find definitions of key words used in this subpart? 63.1176...Pollutants for Mineral Wool Production § 63.1176 Where can I find definitions of key words used in this subpart? The...



Key User Extraction Based on Telecommunication Data (aka. Key Users in Social Network. How to find them?)  

E-print Network

The number of systems that collect vast amount of data about users rapidly grow during last few years. Many of these systems contain data not only about people characteristics but also about their relationships with other system users. From this kind of data it is possible to extract a social network that reflects the connections between system's users. Moreover, the analysis of such social network enables to investigate different characteristics of its members and their linkages. One of the types of examining such network is key users extraction. Key users are these who have the biggest impact on other network members as well as have big influence on network evolution. The obtained about these users knowledge enables to investigate and predict changes within the network. So this knowledge is very important for the people or companies who make a profit from the network like telecommunication company. The second important thing is the ability to extract these users as quick as possible, i.e. developed the algo...

Bródka, Piotr



Finding Intercultural Business Communication Research Sites in Companies (Doing Research).  

ERIC Educational Resources Information Center

Describes important resources for discovering sites for communication research related to the North American Free Trade Agreement (NAFTA), to help identify appropriate companies and contact them. (SR)

Driskill, Linda; Shaw, Peggy



Key Ethical Issues in Pediatric Research: Islamic Perspective, Iranian Experience  

PubMed Central

Objective The importance of pediatric research especially in the ethically proven trials resulted in considerable legislative attempts in association with compiling ethical guidelines. Because of children's vulnerability conducting pediatric research raises different ethical issues; the two most important of which are informed consent and risk-benefit assessment. Differences in religious and socio-cultural context limit implication of ethical standards. Methods At the aim of finding a solution we critically reviewed guidelines, and literatures as well as Islamic points in addition to comparing different viewpoints in application of ethical standards in pediatric research. Findings The literature review showed that pediatric research guidelines and authors’ viewpoints have the same basic ethical core, but there are some variations; depend on cultural, religious, and social differences. Furthermore, these standards have some limitations in defining informed consent according to child's age and capacity upon application. Conclusion In this regard Islamic approach and definition about growth development and puberty sheds light and clarifies a clearer and more rational address to the issue. PMID:23429172

Mobasher, Mina; Salari, Pooneh; Larijani, Bagher



40 CFR 63.2831 - Where can I find definitions of key words used in this subpart?  

Code of Federal Regulations, 2012 CFR

...SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants: Solvent Extraction for Vegetable Oil Production What This Subpart Covers § 63.2831 Where can I find definitions of key words used in this...



40 CFR 63.2831 - Where can I find definitions of key words used in this subpart?  

Code of Federal Regulations, 2014 CFR

...SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants: Solvent Extraction for Vegetable Oil Production What This Subpart Covers § 63.2831 Where can I find definitions of key words used in this...



40 CFR 63.2831 - Where can I find definitions of key words used in this subpart?  

Code of Federal Regulations, 2010 CFR

...POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for Hazardous Air Pollutants: Solvent Extraction for Vegetable Oil Production What This Subpart Covers § 63.2831 Where can I find definitions of key words used in this...



40 CFR 63.2831 - Where can I find definitions of key words used in this subpart?  

Code of Federal Regulations, 2011 CFR

...POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for Hazardous Air Pollutants: Solvent Extraction for Vegetable Oil Production What This Subpart Covers § 63.2831 Where can I find definitions of key words used in this...



40 CFR 63.2831 - Where can I find definitions of key words used in this subpart?  

Code of Federal Regulations, 2013 CFR

...SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants: Solvent Extraction for Vegetable Oil Production What This Subpart Covers § 63.2831 Where can I find definitions of key words used in this...



Genetically Informative Research on Adolescent Substance Use: Methods, Findings, and Challenges  

ERIC Educational Resources Information Center

Objective: To provide an overview of the genetic epidemiology of substance use and misuse in adolescents. Method: A selective review of genetically informative research strategies, their limitations, and key findings examining issues related to the heritability of substance use and substance use disorders in children and adolescents is presented.…

Lynskey, Michael T.; Agrawal, Arpana; Heath, Andrew C.



Researchers Find Gene Mutation That May Protect Against Heart Disease  


... on this page, please enable JavaScript. Researchers Find Gene Mutation That May Protect Against Heart Disease Rare ... Preidt Wednesday, November 12, 2014 Related MedlinePlus Pages Genes and Gene Therapy Heart Diseases WEDNESDAY, Nov. 12, ...


Finding \\  

Microsoft Academic Search

Different data mining algorithms applied to the same data can result in similar findings, typically in the form of rules. These similarities can be exploited to identify especially powerful rules, in particular those that are common to the different algorithms. This research focuses on the independent application of association and classification mining algorithms to the same data to discover common

Karthik Rajasethupathy; Anthony Scime; Kulathur S. Rajasethupathy; Gregg R. Murray



Multiple Perpetrator Rape: Naming an Offence and Initial Research Findings  

ERIC Educational Resources Information Center

Multiple perpetrator rape presents a significant problem nationally and internationally. However, previous research is limited and findings are often contradictory. The details of 101 rape allegations recorded in a six-month period in a large police force in England were analysed. Findings are presented about case classification, victim and…

Horvath, Miranda Angel Helena; Kelly, Liz



Environmentally Mediated Risks for Psychopathology: Research Strategies and Findings  

ERIC Educational Resources Information Center

Objective: To consider the research design requirements needed to provide a rigorous test of environmental mediation hypotheses and to summarize the main findings from research using such designs. Method: Selective review of empirical evidence dealing with psychopathology. Results: There is robust evidence of environmentally mediated risks for…

Rutter, Michael



Case Western researchers present new findings for glioblastoma

Physician-scientists from University Hospitals (UH), Case Medical Center's Seidman Cancer Center and Case Western Reserve University School of Medicine presented new research findings this week at the Annual Meeting of the American Association for Cancer Research (AACR) in Chicago. One study sought to identify protein biomarkers that can help physicians determine which patients may benefit from standard treatment for GBM.


Researchers Find Stem Cells That Help Nails Regenerate  


... on this page, please enable JavaScript. Researchers Find Stem Cells That Help Nails Regenerate Normal function helps with ... November 24, 2014 Related MedlinePlus Pages Nail Diseases Stem Cells MONDAY, Nov. 24, 2014 (HealthDay News) -- Researchers have ...


Recruiting Underserved Mothers to Medical Research: Findings from North Carolina  

PubMed Central

Representative samples are required for ethical, valid, and useful health research. Yet, recruiting participants, especially from historically underserved communities, can be challenging. This paper presents findings from in-depth interviews with 40 mothers about factors that might influence their willingness to participate or allow their children to participate in medical research. Saliency analysis organizes the findings. Frequent and important salient themes about research participation included concerns that it might cause participants harm, hope that participants might gain a health benefit, and recognition that time and transportation resources could limit participation. Ultimately, we propose that a theoretical model, such as the Theory of Planned Behavior (TPB), will facilitate more systematic evaluation of effective methods for recruitment and retention of participants in medical research. Future research should explore the utility of such a model for development of effective recruitment and retention strategies. PMID:24185171

Spears, Chaya R.; Sandberg, Joanne C.; O’Neill, Jenna L.; Grzywacz, Joseph G.; Howard, Timothy D.; Feldman, Steven R.; Arcury, Thomas A.



In Search of New Ideas, Research Findings, and Emerging Technologies? Here's Where To Find Them.  

ERIC Educational Resources Information Center

There are many avenues available to computer-assisted instruction (CAI) practitioners and developers in search of access to new ideas, research findings, and emerging technologies that will assist them in developing CAI products. Seven such avenues are described in detail: (1) graduate student interns, who bring unique insights, theory, and…

Powell, Gary C.


Example: tom bosley Key Finding: Including temporal information in snippets is valuable for trending queries.  

E-print Network

Search Snippets Krysta M. Svore Microsoft Research Jaime Teevan Microsoft Research Susan T. Dumais Microsoft Research Anagha Kulkarni Carnegie lung cancer. Temporal Snippet (with new content)

Dumais, Susan


Who are the key players in a new translational research network?  

PubMed Central

Background Professional networks are used increasingly in health care to bring together members from different sites and professions to work collaboratively. Key players within these networks are known to affect network function through their central or brokerage position and are therefore of interest to those who seek to optimise network efficiency. However, their identity may not be apparent. This study using social network analysis to ask: (1) Who are the key players of a new translational research network (TRN)? (2) Do they have characteristics in common? (3) Are they recognisable as powerful, influential or well connected individuals? Methods TRN members were asked to complete an on-line, whole network survey which collected demographic information expected to be associated with key player roles, and social network questions about collaboration in current TRN projects. Three questions asked who they perceived as powerful, influential and well connected. Indegree and betweenness centrality values were used to determine key player status in the actual and perceived networks and tested for association with demographic and descriptive variables using chi square analyses. Results Response rate for the online survey was 76.4% (52/68). The TRN director and manager were identified as key players along with six other members. Only two of nine variables were associated with actual key player status; none with perceived. The main finding was the mismatch between actual and perceived brokers. Members correctly identified two of the three central actors (the two mandated key roles director and manager) but there were only three correctly identified actual brokers among the 19 perceived brokers. Possible reasons for the mismatch include overlapping structures and weak knowledge of members. Conclusions The importance of correctly identifying these key players is discussed in terms of network interventions to improve efficiency. PMID:23987790



Becoming a Scientist: Research Findings on STEM Students' Gains from Conducting Undergraduate Research  

NASA Astrophysics Data System (ADS)

Undergraduate research is widely believed to enhance STEM students' education and increase their persistence to graduate education and careers in the sciences. Yet until very recently, little evidence from research and evaluation studies was available to substantiate such claims and document what students gain from doing undergraduate research or how these gains come about. We have conducted a three-year qualitative research study of STEM students participating in UR at four liberal arts colleges with a strong tradition of faculty-led summer research apprenticeships. Benefits to students reported by both students and their faculty advisors are categorized into six main categories of gains in skills, knowledge, "thinking like a scientist," career preparation, career development, and personal and professional growth. Student and faculty observations are strongly corroborative, but also differ in interesting ways that reflect the distinct perspectives of each group: students are still in the midst of discovering their own career paths while faculty advisors have observed the later career development of their past research students. While not all students find UR to heighten their interest in graduate school, they do find it a powerful growth experience that clarifies their career ambitions by providing a "real world" experience of science. For students whose interest in science is reinforced, UR has a significant role in their professional socialization into the culture and norms of science, which we call "becoming a scientist," through interactions that draw them into the scientific community and experiences that deepen their understanding of the nature of research. Cumulatively, the qualitative data set of nearly 350 interviews offers a rich portrayal of the UR enterprise from a variety of perspectives. Longitudinal data enable us to track the influence of UR on students' career and education trajectories in the years after college, and comparative data from a group of students who did not undertake UR or pursued alternate experiences reveal the extent to which some benefits of UR may be derived from other experiences. Faculty interviews reveal the costs and benefits to faculty of participating in this intensive form of science education. The presentation will highlight key findings and emphasize their relevance to faculty and program directors undertaking UR or seeking to generate its benefits through other activities.

Hunter, A.; Laursen, S.; Thiry, H.; Seymour, E.



Facilitating Research Faculty Participation in CBPR: Development of a Model Based on Key Informant Interviews  

PubMed Central

Background Community based participatory research (CBPR) may enhance the translational research process; however this would require increased institutional capacity for community engaged research. In this paper we first describe results of key informant interviews with academic health center faculty regarding facilitators to faculty participation in CBPR partnerships and then propose a model arising from these results for how increased capacity may be achieved. Methods Participants were 13 key informant faculty of varying levels of expertise in CBPR at a large university academic health center. Interviews were recorded and transcribed. A thematic content analysis of each interview was conducted by research team members. Results Facilitators reported by faculty representing five health science schools were grouped into five thematic areas: 1) researcher personal attributes including an innate orientation towards working with community, 2) positive attitudes towards collaboration, 3) a partnership-building skill set, 4) community partners who are ready and eager to collaborate, and 5) supportive institutional policies and procedures. Conclusions We propose a model describing the relationship between personal attributes, learned/environmental factors and community facilitators that may be utilized to promote increased institutional capacity for CBPR and thus increase the likelihood of the successful translation of research findings into community settings. PMID:21500397

Allen, Michele L.; Culhane-Pera, Kathleen; Pergament, Shannon; Call, Kathleen T.



Researchers’ views on return of incidental genomic research results: qualitative and quantitative findings  

PubMed Central

Purpose Comprehensive genomic analysis including exome and genome sequencing is increasingly being utilized in research studies, leading to the generation of incidental genetic findings. It is unclear how researchers plan to deal with incidental genetic findings. Methods We conducted a survey of the practices and attitudes of 234 members of the US genetic research community and performed qualitative semistructured interviews with 28 genomic researchers to understand their views and experiences with incidental genetic research findings. Results We found that 12% of the researchers had returned incidental genetic findings, and an additional 28% planned to do so. A large majority of researchers (95%) believe that incidental findings for highly penetrant disorders with immediate medical implications should be offered to research participants. However, there was no consensus on returning incidental results for other conditions varying in penetrance and medical actionability. Researchers raised concerns that the return of incidental findings would impose significant burdens on research and could potentially have deleterious effects on research participants if not performed well. Researchers identified assistance needed to enable effective, accurate return of incidental findings. Conclusion The majority of the researchers believe that research participants should have the option to receive at least some incidental genetic research results. PMID:23807616

Klitzman, Robert; Appelbaum, Paul S.; Fyer, Abby; Martinez, Josue; Buquez, Brigitte; Wynn, Julia; Waldman, Cameron R.; Phelan, Jo; Parens, Erik; Chung, Wendy K.



KEY-FINDING WITH INTERVAL PROFILES Sren Tjagvad Madsen Gerhard Widmer  

E-print Network

of Finnish folk songs (see be- low) along with the profiles learned from inventions and fugues by J. S. Bach and minor keys. Similarly an interval profile weights for two successive notes the 12 Ã? 12 possible tone in Fig. 1 it seems that the tonic is the most stable scale degree, fol- lowed by the other two members

Widmer, Gerhard


Monitoring the Future: National Results on Adolescent Drug Use. Overview of Key Findings, 2006  

ERIC Educational Resources Information Center

This report provides a summary of drug use trends from a survey of nearly 50,000 eighth-, tenth-, and twelfth- grade students nationwide. It also includes perceived risk, personal disapproval, and perceived availability of each drug by this group. A synopsis of the methods used in the study and an overview of the key results from the 2006 survey…

Johnston, Lloyd D., O'Malley, Patrick M.; Bachman, Jerald G.; Schulenberg, John E.



September 17, 2010 LSUHSC research finds cause & remedy for learning &  

E-print Network

of medical marijuana LSUHSC research finds combo of plant nutrients kills breast cancer cells Chancellor on the main component of marijuana, delta-9- tetrahydrocannabinol (THC), for some cancer patients to treat a study that identified the cause of learning and memory deficits associated with medical marijuana use


Humor, Laughter, and Physical Health: Methodological Issues and Research Findings  

Microsoft Academic Search

All published research examining effects of humor and laughter on physical health is reviewed. Potential causal mechanisms and methodological issues are discussed. Laboratory experiments have shown some effects of exposure to comedy on several components of immunity, although the findings are inconsistent and most of the studies have methodological problems. There is also some evidence of analgesic effects of exposure

Rod A. Martin



Researcher finds some bees evolved to shout at competitors  

E-print Network

Researcher finds some bees evolved to shout at competitors July 7, 2014 Certain species of stingless bees in Brazil have been found to protect their sources of nectar and pollen from potential in other bee species. Dr. Elinor Lichtenberg from Washington State University made this discovery during

Nieh, James


Educational Financing in Developing Countries: Research Findings and Contemporary Issues.  

ERIC Educational Resources Information Center

This study focuses on contemporary issues of educational financing in developing countries and on available research findings as these relate, or can be related, to these issues. The first two chapters are analytical, examining common educational finance issues and testing the conventional wisdom of certain usual proposals. Chapter 1, "Issues in…

Schiefelbein, Ernesto


2012 CUCSA Staff Engagement Survey -UC Irvine Summary Key Findings for UC Irvine for Career Non-Representative Staff  

E-print Network

2012 CUCSA Staff Engagement Survey - UC Irvine Summary Key Findings for UC Irvine for Career Non-Representative Staff 85% are motivated to go beyond their job responsibilities and 78% would recommend UC Irvine break engagement down, 39% of employees are fully plugged in at UC Irvine , 21% are engaged but report

Loudon, Catherine


Monitoring the Future National Results on Adolescent Drug Use: Overview of Key Findings, 2011  

ERIC Educational Resources Information Center

Monitoring the Future (MTF) is a long-term study of American adolescents, college students, and adults through age 50. It has been conducted annually by the University of Michigan's Institute for Social Research since its inception in 1975 and is supported under a series of investigator-initiated, competing research grants from the National…

Johnston, Lloyd D.; O'Malley, Patrick M.; Bachman, Jerald G.; Schulenberg, John E.



Monitoring the Future National Results on Adolescent Drug Use: Overview of Key Findings, 2010  

ERIC Educational Resources Information Center

Monitoring the Future (MTF) is a long-term study of American adolescents, college students, and adults through age 50. It has been conducted annually by the University of Michigan's Institute for Social Research since its inception in 1975 and is supported under a series of investigator-initiated, competing research grants from the National…

Johnston, Lloyd D.; O'Malley, Patrick M.; Bachman, Jerald G.; Schulenberg, John E.



UCSD researchers find enzyme accelerates malignant stem cell cloning in chronic myeloid leukemia

An international team, headed by researchers at the University of California, San Diego School of Medicine, has identified a key enzyme in the reprogramming process that promotes malignant stem cell cloning and the growth of chronic myeloid leukemia (CML), a cancer of the blood and marrow that experts say is increasing in prevalence. The findings are published in the Dec. 24 online early edition of the Proceedings of the National Academy of Sciences (PNAS). UCSD is home to the Moores Comprehensive Cancer Center.


Key findings from the Indian Ocean Climate Initiative and their impact on policy development in Australia  

Microsoft Academic Search

Since the mid-1970s the climatic changes that have taken place in southwest Western Australia have generated a variety of\\u000a impacts, the most prominent of which is a reduction in dam inflows of at least 50 percent. These impacts were the catalyst\\u000a for the formation of the Indian Ocean Climate Initiative in 1998, a research partnership between two national research organizations

Bryson C. Bates; Pandora Hope; Brian Ryan; Ian Smith; Steve Charles



Recreation ecology research findings: Implications for wilderness and park managers  

USGS Publications Warehouse

Recreationists unintentionally trample vegetation, erode soil, and disturb wildlife. Such human-related impacts present a dilemma for managers charged with the dual objectives of providing recreational opportunities and preserving natural environments. This paper presents some of the principal findings and management implications from research on visitor impacts to protected areas, termed recreation ecology research. This field of study seeks to identify the type and extent of resource impacts and to evaluate relationships between use-related, environmental, and managerial factors. The capabilities and managerial utility of recreation impact monitoring are also described.

Marion, J.L.



Monitoring the Future National Results on Adolescent Drug Use: Overview of Key Findings, 1999.  

ERIC Educational Resources Information Center

This booklet presents an overview of the findings pertaining to eighth, tenth, and twelfth grade students from the 1999 Monitoring the Future Study. This overview focuses on recent trends in the use of various licit and illicit drugs. It also examines trends in the levels of perceived risk and personal disapproval associated with each drug, which…

Johnston, Lloyd D.; O'Malley, Patrick M.; Bachman, Jerald G.


Developing Intuition: The Key to Creative Futures Research.  

ERIC Educational Resources Information Center

Futures research involves speculation about alternative developments based upon existing data and potential choices. Effective futures research requires creativity in scientific practice rather than an overemphasis on reason. In discussing the important role of intuition in futures research, characteristics of creative scientists are reviewed and…

Southern, Stephen; Domzalski, Suzanne


Organizational Social Network Research: Core Ideas and Key Debates  

Microsoft Academic Search

Given the growing popularity of the social network perspective across diverse organizational subject areas, this review examines the coherence of the research tradition (in terms of leading ideas from which the diversity of new research derives) and appraises current directions and controversies. The leading ideas at the heart of the organizational social network research program include: an emphasis on relations

Martin Kilduff; Daniel J. Brass



Sound and Music Computing: Research Trends and Some Key Issues  

Microsoft Academic Search

This contribution attempts to give an overview of current research trends and open research problems in the rich field of Sound and Music Computing (SMC). To that end, the field is roughly divided into three large areas related to Sound, Music, and Interaction, respectively, and within each of these, major research trends are briefly described. In addition, for each sub-field

Gerhard Widmer; Davide Rocchesso; Vesa Välimäki; Cumhur Erkut; Fabien Gouyon; Daniel Pressnitzer; Henri Penttinen; Pietro Polotti; Gualtiero Volpe



Humor, laughter, and physical health: methodological issues and research findings.  


All published research examining effects of humor and laughter on physical health is reviewed. Potential causal mechanisms and methodological issues are discussed. Laboratory experiments have shown some effects of exposure to comedy on several components of immunity, although the findings are inconsistent and most of the studies have methodological problems. There is also some evidence of analgesic effects of exposure to comedy, although similar findings are obtained with negative emotions. Few significant correlations have been found between trait measures of humor and immunity, pain tolerance, or self-reported illness symptoms. There is also little evidence of stress-moderating effects of humor on physical health variables and no evidence of increased longevity with greater humor. More rigorous and theoretically informed research is needed before firm conclusions can be drawn about possible health benefits of humor and laughter. PMID:11439709

Martin, R A



Research Infusion Collaboration: Finding Defect Patterns in Reused Code  

NASA Technical Reports Server (NTRS)

The 'Finding Defect Patterns in Reused Code' Research Infusion Collaboration was performed by Jet Propulsion Laboratory/Caltech under Contract 104-07-02.679 102 197 08.14.4. This final report describes the collaboration and documents the findings, including lessons learned.The research infusion collaboration characterized, using Orthogonal Defect Classification, defect reports for code that will be reused in mission-critical software on Deep Space Network Antenna controllers. Code reuse is estimated to be 90%, so it is important to identify systemic defects, or patterns, prior to reuse of this code. The work also identified ways to avoid certain types of defects and to test more efficiently.The primary objectives of the project were:to analyze defect patterns of the code to be reused based on the defects'Orthogonal Defect Classification (ODC)and to achieve a successful infusion of ODC to a project.

Lutz, Robyn R.; Morgan, Scott; Do, Tuan; Mikulski, Carmen; Berg Strain, Martha; Rockwell, Steve; Wilkinson, Belinda



Reporting back research findings: a case study of community-based tourism research in northern Canada  

Microsoft Academic Search

In this article, experiences of reporting back research results to three communities in northern Canada (Churchill, Manitoba, Cambridge Bay and Pond Inlet, both in Nunavut) are described. The research examined residents' attitude towards tourism development. Reporting of initial findings was integral to the research process to ensure that results made sense from a local perspective. The research engaged a variety

Emma J. Stewart; Dianne Draper



Investigating Ideomotor Cognition with Motorvisual Priming Paradigms: Key Findings, Methodological Challenges, and Future Directions  

PubMed Central

Ideomotor theory claims that perceptual representations of action-effects are functionally involved in the planning of actions. Strong evidence for this claim comes from a phenomenon called motorvisual priming. Motorvisual priming refers to the finding that action planning directly affects perception, and that the effects are selective for stimuli that share features with the planned action. Motorvisual priming studies have provided detailed insights into the processing of perceptual representations in action planning. One important finding is that such representations in action planning have a categorical format, whereas metric representations are not anticipated in planning. Further essential findings regard the processing mechanisms and the time course of ideomotor cognition. Perceptual representations of action-effects are first activated by action planning and then bound into a compound representation of the action plan. This compound representation is stabilized throughout the course of the action by the shielding of all involved representations from other cognitive processes. Despite a rapid growth in the number of motorvisual priming studies in the current literature, there are still many aspects of ideomotor cognition which have not yet been investigated. These aspects include the scope of ideomotor processing with regard to action types and stimulus types, as well as the exact nature of the binding and shielding mechanisms involved. PMID:23189067

Thomaschke, Roland



Supporting Primary and Secondary Beginning Teachers Online: Key Findings of the Education Alumni Support Project  

ERIC Educational Resources Information Center

During 2005, the Education Alumni Support Project (EdASP) (Maxwell, Smith, Baxter, Boyd, Harrington, Jenkins, Sargeant & Tamatea 2006) provided online support for University of New England (UNE) graduand, and later, graduate, teachers as they commenced their careers. The project was based on research which reported that many beginning teachers did…

Maxwell, T. W.; Harrington, I.; Smith, H. J.



DCCPS: BRP: PCRB: Key Initiatives: HPV and Cervical Cancer Research

Glyn Elwyn, BA, MB, BCh, FRCGP, PhD is a primary care clinician with research interests in shared decision making, risk communication, the design and evaluation of decision support interventions and the integration of health informatics into clinical practice. He was appointed inter-school Distinguished Research Chair at Cardiff University in May 2005, and is the Chair of the Clinical Epidemiology Interdisciplinary Research Group at the School of Medicine and Director of Research at the Department of Primary Care and Public Health.


Research on Key Technology and Applications for Internet of Things  

NASA Astrophysics Data System (ADS)

The Internet of Things (IOT) has been paid more and more attention by the academe, industry, and government all over the world. The concept of IOT and the architecture of IOT are discussed. The key technologies of IOT, including Radio Frequency Identification technology, Electronic Product Code technology, and ZigBee technology are analyzed. The framework of digital agriculture application based on IOT is proposed.

Chen, Xian-Yi; Jin, Zhi-Gang


MIT-led study finds turning on key enzyme blocks tumor formation

Unlike ordinary cells, cancer cells devote most of their energy to reproducing themselves. To do this, they must trigger alternative metabolic pathways that produce new cellular building blocks, such as DNA, carbohydrates and lipids. Chemical compounds that disrupt an enzyme critical to this metabolic diversion prevent tumors from forming in mice, according to an MIT-led study appearing online in Nature Chemical Biology on Aug. 26. MIT is home to the David H. Koch Institute for Integrative Cancer Research.


Key findings of the US Cystic Fibrosis Foundation's clinical practice benchmarking project.  


Benchmarking is the process of using outcome data to identify high-performing centres and determine practices associated with their outstanding performance. The US Cystic Fibrosis Foundation (CFF) Patient Registry contains centre-specific outcomes data for all CFF-certified paediatric and adult cystic fibrosis (CF) care programmes in the USA. The CFF benchmarking project analysed these registry data, adjusting for differences in patient case mix known to influence outcomes, and identified the top-performing US paediatric and adult CF care programmes for pulmonary and nutritional outcomes. Separate multidisciplinary paediatric and adult benchmarking teams each visited 10 CF care programmes, five in the top quintile for pulmonary outcomes and five in the top quintile for nutritional outcomes. Key practice patterns and approaches present in both paediatric and adult programmes with outstanding clinical outcomes were identified and could be summarised as systems, attitudes, practices, patient/family empowerment and projects. These included: (1) the presence of strong leadership and a well-functioning care team working with a systematic approach to providing consistent care; (2) high expectations for outcomes among providers and families; (3) early and aggressive management of clinical declines, avoiding reliance on 'rescues'; and (4) patients/families that were engaged, empowered and well informed on disease management and its rationale. In summary, assessment of practice patterns at CF care centres with top-quintile pulmonary and nutritional outcomes provides insight into characteristic practices that may aid in optimising patient outcomes. PMID:24608546

Boyle, Michael P; Sabadosa, Kathryn A; Quinton, Hebe B; Marshall, Bruce C; Schechter, Michael S



Key Developments in Endocrine Disrupter Research and Human Health  

Microsoft Academic Search

Environmental etiologies involving exposures to chemicals that mimic endogenous hormones are proposed for a number of adverse human health effects, including infertility, abnormal prenatal and childhood development, and reproductive cancers (National Research Council, 1999; World Health Organization, 2002). Endocrine disrupters represent a significant area of environmental research with important implications for human health. This article provides an overview of some

Karen P. Phillips; Warren G. Foster



Interprofessional social and emotional intelligence skills training: study findings and key lessons.  


Frequently changing demands in health care systems have focused attention on the need for emotional competence (EC) - social and emotional intelligence skills, to adapt efficiently, responsively and productively. This paper reports on findings from a workshop that introduced practical EC skills to nearly 1000 participants in education, medicine, mental health and substance abuse counseling. The holistic EC presentations were designed to teach concepts and principles providing each participant with the opportunity for individualized learning. Ninety percent of the participants rated these presentations as valuable and useful. Following this positive response, the approach was adapted to train health professionals serving diverse populations. This report shares our experience teaching various professionals and describes preliminarily testing of the adapted EC training program on a small group of health professionals, whose responsibilities included teamwork, program design, teaching clients and patients EC basics to support healthy practices and self-care. Their positive response supports the need for expanded study and further investigation. PMID:24164409

Flowers, Loma Kaye; Thomas-Squance, Ruth; Brainin-Rodriguez, Jo Ellen; Yancey, Antronette K



Adult Polyglucosan Body Disease: Natural History and Key Magnetic Resonance Imaging Findings  

PubMed Central

Objective Adult polyglucosan body disease (APBD) is an autosomal recessive leukodystrophy characterized by neurogenic bladder, progressive spastic gait, and peripheral neuropathy. Polyglucosan bodies accumulate in the central and peripheral nervous systems and are often associated with glycogen branching enzyme (GBE) deficiency. To improve clinical diagnosis and enable future evaluation of therapeutic strategies, we conducted a multinational study of the natural history and imaging features of APBD. Methods We gathered clinical, biochemical, and molecular findings in 50 APBD patients with GBE deficiency from Israel, the United States, France, and the Netherlands. Brain and spine magnetic resonance images were reviewed in 44 patients. Results The most common clinical findings were neurogenic bladder (100%), spastic paraplegia with vibration loss (90%), and axonal neuropathy (90%). The median age was 51 years for the onset of neurogenic bladder symptoms, 63 years for wheelchair dependence, and 70 years for death. As the disease progressed, mild cognitive decline may have affected up to half of the patients. Neuroimaging showed hyperintense white matter abnormalities on T2 and fluid attenuated inversion recovery sequences predominantly in the periventricular regions, the posterior limb of the internal capsule, the external capsule, and the pyramidal tracts and medial lemniscus of the pons and medulla. Atrophy of the medulla and spine was universal. p.Y329S was the most common GBE1 mutation, present as a single heterozygous (28%) or homozygous (48%) mutation. Interpretation APBD with GBE deficiency, with occasional exceptions, is a clinically homogenous disorder that should be suspected in patients with adult onset leukodystrophy or spastic paraplegia with early onset of urinary symptoms and spinal atrophy. PMID:23034915

Mochel, Fanny; Schiffmann, Raphael; Steenweg, Marjan E.; Akman, Hasan O.; Wallace, Mary; Sedel, Frédéric; Laforêt, Pascal; Levy, Richard; Powers, J. Michael; Demeret, Sophie; Maisonobe, Thierry; Froissart, Roseline; Da Nobrega, Bruno Barcelos; Fogel, Brent L.; Natowicz, Marvin R.; Lubetzki, Catherine; Durr, Alexandra; Brice, Alexis; Rosenmann, Hanna; Barash, Varda; Kakhlon, Or; Gomori, J. Moshe; van der Knaap, Marjo S.; Lossos, Alexander



Authentic Research Immersion Experiences: the Key to Enduring Understandings  

NASA Astrophysics Data System (ADS)

Do authentic research experiences have a role in today's classrooms? Where do they fit into the constrained curriculum units and high-stakes testing regimen that define a teacher's world? It is possible, even in today's somewhat narrow teaching environment, to integrate authentic research into the classroom and evolve away from the worksheets and lessons that simply "teach to the test"? Authentic research immersion experiences must be carefully packaged the for classroom use with clear alignment to standards and a learning curve that is not too daunting. By helping teachers to see the value in replacing curricular units with authentic research experiences and designing the research program to fit within a teacher's needs, the rate of successful adoption of the research program becomes much higher. As a result, not only do their students reap the educational rewards of becoming active research participants in the process of science and learn it from the inside out, but the opportunity for the teachers to grow professionally in content and science process knowledge is also an additional benefit. NASA has had and continues to have a significant role in providing these data and mission- related immersion experiences for elementary classrooms through graduate school students.

Klug, S. L.



'Longevity Gene' One Key to Long Life, Research Suggests  


... Sofiya Milman, an assistant professor at the Albert Einstein College of Medicine in New York City. Milman ... The results build on work that began at Einstein in the late 1990s. Researchers there have been ...


DCCPS: BRP: PCRB: Key Initiatives: HPV and Cervical Cancer Research

Dr. Weiner is an associate professor in the department of health policy and management in the school of public health of the University of North Carolina at Chapel Hill (UNC); and director of the program on health care organization at the Cecil G. Sheps Center for Health Services Research. His research interests focus on the adoption, implementation, and sustainability of innovations in health care organizations.


UNC study finds cancer gene family member functions key to cell adhesion and migration

While cancer researchers are learning more of WTX and how its loss contributes to cancer formation, virtually nothing is known of FAM123C or FAM123A, the latter of which is a highly abundant protein within neurons, cells that receive and send messages from the body to the brain and back to the body. A UNC-led team of scientists used sophisticated technologies to identify and describe the protein interactions that distinguish each member of the WTX family. They found that unlike WTX and FAM123C, FAM123A interacts with a specific set of proteins that regulates cell adhesion and migration, processes essential to normal cell functioning and which, when mutated, contribute to human diseases such as cancer or Alzheimer’s.


The Genetics of Autism: Key Issues, Recent Findings and Clinical Implications  

PubMed Central

Autism spectrum disorders (ASD’S) are highly heritable. Consequently, gene discovery promises to help illuminate the pathophysiology of these syndromes, yielding important opportunities for the development of novel treatments and a more nuanced understanding of the natural history of these disorders. Although the underlying genetic architecture of ASD’s is not yet known, the literature demonstrates that it is not, writ large, a monogenic disorder with Mendelian inheritance, but rather a group of complex genetic syndromes with risk deriving from genetic variations in multiple genes. The widely accepted “Common Disease-Common Variant” hypothesis predicts that the risk alleles in ASD’s and other complex disorders will be common in the general population. However, recent evidence from gene discovery efforts in a wide range of diseases raises important questions regarding the overall applicability of the theory and the extent of its usefulness in explaining individual genetic liability. In contrast, considerable evidence points to the importance of rare alleles both with regard to their value in providing a foothold into the molecular mechanisms of ASD and their overall contribution to the population-wide risk. This chapter reviews the origins of the common versus rare variant debate, highlights recent findings in the field, and addresses the clinical implications of both common and rare variant discoveries. PMID:20159341

El-Fishawy, Paul; State, Matthew W.



Finding qualitative research: an evaluation of search strategies  

PubMed Central

Background Qualitative research makes an important contribution to our understanding of health and healthcare. However, qualitative evidence can be difficult to search for and identify, and the effectiveness of different types of search strategies is unknown. Methods Three search strategies for qualitative research in the example area of support for breast-feeding were evaluated using six electronic bibliographic databases. The strategies were based on using thesaurus terms, free-text terms and broad-based terms. These strategies were combined with recognised search terms for support for breast-feeding previously used in a Cochrane review. For each strategy, we evaluated the recall (potentially relevant records found) and precision (actually relevant records found). Results A total yield of 7420 potentially relevant records was retrieved by the three strategies combined. Of these, 262 were judged relevant. Using one strategy alone would miss relevant records. The broad-based strategy had the highest recall and the thesaurus strategy the highest precision. Precision was generally poor: 96% of records initially identified as potentially relevant were deemed irrelevant. Searching for qualitative research involves trade-offs between recall and precision. Conclusions These findings confirm that strategies that attempt to maximise the number of potentially relevant records found are likely to result in a large number of false positives. The findings also suggest that a range of search terms is required to optimise searching for qualitative evidence. This underlines the problems of current methods for indexing qualitative research in bibliographic databases and indicates where improvements need to be made. PMID:15070427

Shaw, Rachel L; Booth, Andrew; Sutton, Alex J; Miller, Tina; Smith, Jonathan A; Young, Bridget; Jones, David R; Dixon-Woods, Mary



DCCPS: BRP: PCRB: Key Initiatives: HPV and Cervical Cancer Research

Stephen Humphrey is an Associate Professor of Management in the Smeal College of Business at Pennsylvania State University. Dr. Humphrey's research, which includes a focus on teamwork and the contributors to team success, has been published in notable psychology and management peer review journals. Dr. Humphrey earned a Ph.D. in Organizational Behavior and Human Resources Management from Michigan State University.


Student as Communication Skills Trainer: From Research to "Concept Keys"  

ERIC Educational Resources Information Center

Although textbooks are filled with practical communication advice, many students overlook the importance of basing practical advice about communication on quality research. This oversight is important for two reasons. First, given the explosion of self-help remedies focused on communication, students should learn to distinguish between…

Bodie, Graham D.



Researchers discover key mutation in acute myeloid leukemia

Researchers have discovered mutations in a particular gene that affects the treatment prognosis for some patients with acute myeloid leukemia (AML), an aggressive blood cancer that kills 9,000 Americans annually. The scientists report their results in the Nov. 11, 2010, online issue of The New England Journal of Medicine.


Diversity: Key to Success of Research Teams of The Future  

NSDL National Science Digital Library

A presentation from the invited speaker, Dr. Patricia Molina, given at the APS/NIDDK Minority Travel Fellow Luncheon during EB 2008. Dr. Molina highlights studies showing that diversity in work environments improves the quality of research. She points out that APSÃÂs strategic directions to promote the advancement of underrepresented minority students, and encouraged those in attendance to recognize their essential role in the increasingly global scientific community.



Managing Incidental Findings and Research Results in Genomic Research Involving Biobanks & Archived Datasets  

PubMed Central

Biobanks and archived datasets collecting samples and data have become crucial engines of genetic and genomic research. Unresolved, however, is what responsibilities biobanks should shoulder to manage incidental findings (IFs) and individual research results (IRRs) of potential health, reproductive, or personal importance to individual contributors (using “biobank” here to refer to both collections of samples and collections of data). This paper reports recommendations from a 2-year, NIH-funded project. The authors analyze responsibilities to manage return of IFs and IRRs in a biobank research system (primary research or collection sites, the biobank itself, and secondary research sites). They suggest that biobanks shoulder significant responsibility for seeing that the biobank research system addresses the return question explicitly. When re-identification of individual contributors is possible, the biobank should work to enable the biobank research system to discharge four core responsibilities: to (1) clarify the criteria for evaluating findings and roster of returnable findings, (2) analyze a particular finding in relation to this, (3) re-identify the individual contributor, and (4) recontact the contributor to offer the finding. The authors suggest that findings that are analytically valid, reveal an established and substantial risk of a serious health condition, and that are clinically actionable should generally be offered to consenting contributors. The paper specifies 10 concrete recommendations, addressing new biobanks and biobanks already in existence. PMID:22436882

Wolf, Susan M.; Crock, Brittney N.; Van Ness, Brian; Lawrenz, Frances; Kahn, Jeffrey P.; Beskow, Laura M.; Cho, Mildred K.; Christman, Michael F.; Green, Robert C.; Hall, Ralph; Illes, Judy; Keane, Moira; Knoppers, Bartha M.; Koenig, Barbara A.; Kohane, Isaac S.; LeRoy, Bonnie; Maschke, Karen J.; McGeveran, William; Ossorio, Pilar; Parker, Lisa S.; Petersen, Gloria M.; Richardson, Henry S.; Scott, Joan A.; Terry, Sharon F.; Wilfond, Benjamin S.; Wolf, Wendy A.



Psychological therapies for auditory hallucinations (voices): current status and key directions for future research.  


This report from the International Consortium on Hallucinations Research considers the current status and future directions in research on psychological therapies targeting auditory hallucinations (hearing voices). Therapy approaches have evolved from behavioral and coping-focused interventions, through formulation-driven interventions using methods from cognitive therapy, to a number of contemporary developments. Recent developments include the application of acceptance- and mindfulness-based approaches, and consolidation of methods for working with connections between voices and views of self, others, relationships and personal history. In this article, we discuss the development of therapies for voices and review the empirical findings. This review shows that psychological therapies are broadly effective for people with positive symptoms, but that more research is required to understand the specific application of therapies to voices. Six key research directions are identified: (1) moving beyond the focus on overall efficacy to understand specific therapeutic processes targeting voices, (2) better targeting psychological processes associated with voices such as trauma, cognitive mechanisms, and personal recovery, (3) more focused measurement of the intended outcomes of therapy, (4) understanding individual differences among voice hearers, (5) extending beyond a focus on voices and schizophrenia into other populations and sensory modalities, and (6) shaping interventions for service implementation. PMID:24936081

Thomas, Neil; Hayward, Mark; Peters, Emmanuelle; van der Gaag, Mark; Bentall, Richard P; Jenner, Jack; Strauss, Clara; Sommer, Iris E; Johns, Louise C; Varese, Filippo; García-Montes, José Manuel; Waters, Flavie; Dodgson, Guy; McCarthy-Jones, Simon



Psychological Therapies for Auditory Hallucinations (Voices): Current Status and Key Directions for Future Research  

PubMed Central

This report from the International Consortium on Hallucinations Research considers the current status and future directions in research on psychological therapies targeting auditory hallucinations (hearing voices). Therapy approaches have evolved from behavioral and coping-focused interventions, through formulation-driven interventions using methods from cognitive therapy, to a number of contemporary developments. Recent developments include the application of acceptance- and mindfulness-based approaches, and consolidation of methods for working with connections between voices and views of self, others, relationships and personal history. In this article, we discuss the development of therapies for voices and review the empirical findings. This review shows that psychological therapies are broadly effective for people with positive symptoms, but that more research is required to understand the specific application of therapies to voices. Six key research directions are identified: (1) moving beyond the focus on overall efficacy to understand specific therapeutic processes targeting voices, (2) better targeting psychological processes associated with voices such as trauma, cognitive mechanisms, and personal recovery, (3) more focused measurement of the intended outcomes of therapy, (4) understanding individual differences among voice hearers, (5) extending beyond a focus on voices and schizophrenia into other populations and sensory modalities, and (6) shaping interventions for service implementation. PMID:24936081

Thomas, Neil; Hayward, Mark; Peters, Emmanuelle; van der Gaag, Mark; Bentall, Richard P.; Jenner, Jack; Strauss, Clara; Sommer, Iris E.; Johns, Louise C.; Varese, Filippo; García-Montes, José Manuel; Waters, Flavie; Dodgson, Guy; McCarthy-Jones, Simon



DCCPS: BRP: PCRB: Key Initiatives: HPV and Cervical Cancer Research

Stephen M. Fiore, Ph.D. is an Associate Professor in the University of Central Florida’s Cognitive Sciences Program in the Department of Philosophy, and Director of the Cognitive Sciences Laboratory at UCF’s Institute for Simulation and Training. Dr. Fiore’s research interests include aspects of the cognitive, social, and computational sciences in the investigation of learning and performance in individuals and teams. His scholarly publications have shed light on learning, memory, and problem solving at the individual and the group level. Dr.


NOAA atmospheric baseline observatories provide key data for researchers  

NASA Astrophysics Data System (ADS)

GREENLAND—Brian Vasel, an admitted “Poley” who has overwintered twice at the South Pole, is drawn to ice sheets. That's a good thing for him: Two of the six atmospheric baseline observatories that he oversees as field operations manager for the Global Monitoring Division of the U.S. National Oceanic and Atmospheric Administration's (NOAA) Earth System Research Laboratory (ESRL) are located on ice sheets, one at the South Pole and the other at Summit Station, in central Greenland, atop 3.2 kilometers of ice. All of the NOAA atmospheric baseline observatories (ABOs)—including those at Barrow, Alaska; Trinidad Head, Calif.; Mauna Loa, Hawaii; and American Samoa—were strategically selected for their unique locations to conduct a variety of atmospheric and solar measurements. For instance, Summit Station is a high-latitude, high-altitude site that is in the free troposphere, and the site in American Samoa is in the Intertropical Convergence Zone, Vasel noted.

Showstack, Randy



Online Information Exchanges for Parents of Children With a Rare Health Condition: Key Findings From an Online Support Community  

PubMed Central

Background The Internet provides new opportunities for parents of children with difficult illnesses and disabilities to find information and support. The Internet is particularly important for caregivers of children with special needs due to numerous health-related decisions they face. For at-risk populations, online support communities can become key settings and channels for health promotion and communication. Objective This study is an initial exploration of the information-seeking and information-provision processes present in an online support community, which is an area of opportunity and interest for Internet-based medical research and practice. The aim of this study was to explore and describe information-related processes of uncertainty management in relationship to clubfoot. Specifically, the study explored interpersonal communication (information seeking and provision) in an online support community serving the needs of parents of children with clubfoot. Methods The study population consisted of messages posted to an online community by caregivers (parents) of children with clubfoot. The theoretical framework informing the study was the Uncertainty Management Theory (UMT). The study used content analysis to explore and categorize the content of 775 messages. Results Women authored 664 of 775 messages (86%) and men authored 47 messages (6%). Caregivers managed uncertainty through information seeking and provision behaviors that were dynamic and multilayered. The ratio of information-seeking messages to information-provision responses was 1 to 4. All five types of information-seeking behaviors proposed by Brashers’ schema were identified, most of them being correlated. Information seeking using direct questions was found to be positively correlated to self-disclosure (r=.538), offering of a candidate answer (r=.318), and passive information seeking (r=.253). Self-disclosure was found to be positively correlated to provision of a candidate answer (r=.324), second-guessing (r=.149), and passive information seeking (r=.366). Provision of a candidate answer was found to be positively correlated with second-guessing (r=.193) and passive information seeking (r=.223). Second-guessing was found to be positively correlated to passive information seeking (r=.311). All correlations reported above were statistically significant (P<0.01). Of the 775 messages analyzed, 255 (33%) identified a medical professional or institution by name. Detailed medical information was provided in 101 (13%) messages, with the main source of information identified being personal experience rather than medical sources. Conclusion Online communities can be an effective channel for caregivers, especially women, to seek and offer information required for managing clubfoot-related uncertainty. To enhance communication with parents, health care institutions may need to invest additional resources in user-friendly online information sources and online interactions with caregivers of children with special illnesses such as clubfoot. Furthermore, explorations of information-seeking and information-provision behaviors in online communities can provide valuable data for interdisciplinary health research and practice. PMID:23470259

Campo, Shelly; Lowe, John; Andsager, Julie; Morcuende, Jose A



Disclosure and management of research findings in stem cell research and banking: policy statement.  


Prompted by an increased interest of both research participants and the patient advocacy community in obtaining information about research outcomes and on the use of their biological samples; the international community has begun to debate the emergence of an ethical 'duty' to return research results to participants. Furthermore, the use of new technologies (e.g., whole-genome and -exome sequencing) has revealed both genetic data and incidental findings with possible clinical significance. These technologies together with the proliferation of biorepositories, provide a compelling rationale for governments and scientific institutions to adopt prospective policies. Given the scarcity of policies in the context of stem cell research, a discussion on the scientific, ethical and legal implications of disclosing research results for research participants is needed. We present the International Stem Forum Ethics Working Party's Policy Statement and trust that it will stimulate debate and meet the concerns of researchers and research participants alike. PMID:22594334

Isasi, Rosario; Knoppers, Bartha M; Andrews, Peter W; Bredenoord, Annelien; Colman, Alan; Hin, Lee Eng; Hull, Sara; Kim, Ock-Joo; Lomax, Geoffrey; Morris, Clive; Sipp, Douglas; Stacey, Glyn; Wahlstrom, Jan; Zeng, Fanyi



48 CFR 335.071 - Special determinations and findings affecting research and development contracting.  

Code of Federal Regulations, 2010 CFR

...findings affecting research and development contracting. 335.071...Regulations System HEALTH AND HUMAN SERVICES SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 335.071 ...findings affecting research and development contracting. OPDIV...



48 CFR 335.071 - Special determinations and findings affecting research and development contracting.  

Code of Federal Regulations, 2011 CFR

...findings affecting research and development contracting. 335.071...Regulations System HEALTH AND HUMAN SERVICES SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 335.071 ...findings affecting research and development contracting. OPDIV...



NIAMS-Supported Research Finds New Genetic Links to Juvenile Arthritis  


... on Research 2013 June 2013 NIAMS-Supported Research Finds New Genetic Links to Juvenile Arthritis New research ... two important implications, said Thompson. “If we can find a novel disease mechanism, that can inform drug ...


Wireless technologies and accessibility for people with disabilities: findings from a policy research instrument.  


The near universal deployment in the United States of a wide variety of information and communications technologies, both wired and wireless, creates potential barriers to use for several key populations, including the poor, people with disabilities, and the aging. Equal access to wireless technologies and services can be achieved through a variety of mechanisms, including legislation and regulations, market-based solutions, and awareness and outreach-based approaches. This article discusses the results of policy research conducted by the Rehabilitation Engineering Research Center on Wireless Technologies (Wireless RERC) using policy Delphi polling methodology to probe stakeholders' opinions on key access barrier issues and to explore potential policy responses. Participants included disability advocates, disability/wireless technology policy makers, and product developers/manufacturers. Respondent input informed subsequent development of potential policy initiatives to increase access to these technologies. The findings from the Delphi suggest that awareness issues remain most important, especially manufacturer awareness of user needs and availability of consumer information for selecting the most appropriate wireless devices and services. Other key issues included the ability of people with disabilities to afford technologies and inadequacies in legislation and policy making for ensuring their general accessibility, as well as usefulness in emergencies. Technical issues, including interoperability, speech-to-text conversion, and hearing aid compatibility, were also identified by participating stakeholders as important. To address all these issues, Delphi respondents favored goals and options congruent with voluntary market-driven solutions where possible but also supported federal involvement, where necessary, to aid this process. PMID:18939655

Baker, Paul M A; Moon, Nathan W



Columbia University Medical Center researchers find that a new computational approach finds gene that drives aggressive brain cancer

Columbia University Medical Center researchers have combined existing computational tools with a new algorithm called DIGGIT, which 'walks' backward from the master regulators to find the genetic events that drive brain cancer.


1998 National Gun Policy Survey of the National Opinion Research Center: Research Findings  

NSDL National Science Digital Library

The National Opinion Research Center (NORC) at the University of Chicago in collaboration with the Johns Hopkins Center for Gun Policy and Research in 1999 released a final report based on the research findings of a national survey on gun policies. The 64-page study reports on topics such as the regulation of firearms, gun ownership and use, knowledge and attitudes toward guns, gun violence, and safety issues. The report includes thirteen statistical tables and concludes that the American public strongly supports "legislation to regulate firearms, make guns safer, and reduce the accessibility of firearms to criminals and children."

Smith, Tom W.


Biodiversity at Risk Genomes are key to basic research, and may contain solu-  

E-print Network

Biodiversity at Risk Genomes are key to basic research, and may contain solu- tions to many among organisms. To expand this knowledge, biodiversity scientists of the future will need entire ge Preserving the Genomic Diversity of Life on Earth Genomics is shaping the future of biodiversity research

Mathis, Wayne N.


New Seminar Course Coupled Human and Natural Systems (CHANS): Key Issues and Research Frontiers  

E-print Network

New Seminar Course Fall 2013 *** *** *** Coupled Human and Natural Systems (CHANS): Key Issues and Research Frontiers *** *** *** Course Number: FW893 (Section 002) Number of Credits: 1 (for more credits in research on coupled human and natural systems (CHANS, e.g., social-ecological systems, human


School-Based Performance Awards: Research Findings and Future Directions.  

ERIC Educational Resources Information Center

This paper synthesizes research on how motivation influenced teachers at two school-based performance award (SBPA) programs in Kentucky and in North Carolina. The research was conducted between 1995 and 1998 by the Consortium for Policy Research in Education. SBPA programs provide teachers and other school staff with pay bonuses for the…

Kelley, Carolyn; Heneman, Herbert, III; Milanowski, Anthony


Exploring accuracy in journalism stories reporting on neuroscience research findings: A comparative case study.  

E-print Network

??Abstract Neuroscience has seen explosive growth in research and public interest, but research findings are often reported inaccurately, impacting public understanding. Exploratory descriptive case study… (more)

Campbell-Davison, Andrea M



Applying Ad Hoc Institutional Research Findings to College Strategic Planning  

ERIC Educational Resources Information Center

Environmental scanning, enrollment forecasting, budget analyses, and institutional effectiveness assessment are examples of the explicit contributions institutional research offices make to campus strategic planning.

Clagett, Craig A.



USC researchers find new target for prostate cancer treatment

Scientists have found a promising new therapeutic target for prostate cancer. The findings offer evidence that a newly discovered member of a family of cell surface proteins called G-protein coupled receptors (GPCRs) promotes prostate cancer cell growth.


"Response to Comments": Finding the Narrative in Narrative Research  

ERIC Educational Resources Information Center

The author responds to comments by Barone (2009), Clandinin and Murphy (2009), and M. W. Smith (2009) on "The Construction Zone: Literary Elements in Narrative Research" (Coulter & M. L. Smith, 2009). She clarifies issues regarding point of view, authorial surplus, narrative coherence, and the relational qualities of narrative research. She…

Coulter, Cathy A.



Survey of Undergraduate Research Experiences (SURE): First Findings  

Microsoft Academic Search

In this study, I examined the hypothesis that undergraduate research enhances the educational experience of science undergraduates, attracts and retains talented students to careers in science, and acts as a pathway for minority students into science careers. Undergraduates from 41 institutions participated in an online survey on the benefits of undergraduate research experiences. Participants indicated gains on 20 potential benefits

David Lopatto



Finding Nexus: Connecting Youth Work and Research Practices  

ERIC Educational Resources Information Center

Participation in educational and social research helps to develop understanding of how young people learn and to consider wider aspects of their lives to enable their voices to be heard and acted upon. Research also facilitates the articulation and sharing of methodologies across a range of professional practices. We assert that theory and…

Gormally, Sinéad; Coburn, Annette



Seeking Renewal, Finding Community: Participatory Action Research in Teacher Education  

ERIC Educational Resources Information Center

This narrative study describes the experiences of a group of teacher educators as they worked together in a collaborative research activity investigating theories of literacy and the preparation of secondary teachers. The collaboration was organized around the precepts associated with participatory action research (PAR). After four years of…

Draper, Roni Jo; Adair, Marta; Broomhead, Paul; Gray, Sharon; Grierson, Sirpa; Hendrickson, Scott; Jensen, Amy P.; Nokes, Jeffery D.; Shumway, Steven; Siebert, Daniel; Wright, Geoffrey



Roswell Park researchers find prognostic biomarker candidates for ovarian cancer

Cancer researchers at Roswell Park Cancer Institute have identified two independent classes of novel candidate prognostic markers for ovarian cancer, advancing efforts to develop targeted therapies for the disease.


77 FR 33737 - Findings of Research Misconduct; Correction  

Federal Register 2010, 2011, 2012, 2013, 2014

...the first line to read ``Jian Ma, Ph.D.'' 2. On page 32117...change the name ``Dr. Juan Ma'' to read ``Dr. Jian Ma.'' Dated: May 31, 2012. John...Investigative Oversight, Office of Research Integrity. [FR Doc....



MD Anderson researchers find that yoga regulates stress hormones

Through a grant from the National Cancer Institute, researchers are now conducting a Phase III clinical trial in women with breast cancer to further determine the mechanisms of yoga that lead to improvement in physical functioning and quality of life.


Findings of the International Road Tunnel Fire Detection Research Project  

Microsoft Academic Search

\\u000a Abstract\\u000a   Fire detection systems play a crucial role in ensuring safe evacuation and firefighting operations in road tunnels, but information\\u000a on the performance of these systems in tunnels has been limited and guidelines for their application in tunnel environments\\u000a are not fully developed. Recently, the National Research Council of Canada (NRC) and the Fire Protection Research Foundation\\u000a completed a 2-year

Z. G. Liu; A. Kashef; G. Crampton; G. Lougheed; Y. Ko; G. Hadjisophocleous; Kathleen H. Almand



Findings of the International Road Tunnel Fire Detection Research Project  

Microsoft Academic Search

Fire detection systems are essential fire protection elements for road tunnels to detect fires, activate safety systems and\\u000a direct evacuation and firefighting. However, information on the performance of these systems is limited and guidelines for\\u000a application of tunnel fire detection systems are not fully developed. The National Research Council of Canada and the Fire\\u000a Protection Research Foundation, with support of

A. Kashef; Z. G. Liu; G. Lougheed; G. Crampton; K. Yoon; G. Hadjisophocleous; Kathleen H. Almand



MD Anderson researchers find coupling of proteins promotes glioblastoma development:

Two previously unassociated proteins known to be overly active in a variety of cancers bind together to ignite and sustain malignant brain tumors, a research team led by scientists at The University of Texas MD Anderson Cancer Center reports this week in the journal Cancer Cell. This research is the first to connect FoxM1 to a molecular signaling cascade that regulates normal neural stem cells...


The current structure of key actors involved in research on land and soil degradation  

NASA Astrophysics Data System (ADS)

Land and soil conservation topics, the final mandate of the United Convention to Combat desertification in drylands, have been diagnosed as still suffering from a lack of guidance. On the contrary, climate change and biodiversity issues -the other two big subjects of the Rio Conventions- seem to progress and may benefit from the advice of international panels. Arguably the weakness of policy measures and hence the application of scientific knowledge by land users and stakeholders could be the expression of an inadequate research organization and a lack of ability to channel their findings. In order to better understand the size, breadth and depth of the scientific communities involved in providing advice to this convention and to other bodies, this study explores the corpus of international publications dealing with land and/or with soils. A database of several thousands records including a significant part of the literature published so far was performed using the Web of Science and other socio-economic databases such as FRANCIS and CAIRN. We extracted hidden information using bibliometric methods and data mining applied to these scientific publications to map the key actors (laboratories, teams, institutions) involved in research on land and on soils. Several filters were applied to the databases in combination with the word "desertification". The further use of Tetralogie software merges databases, analyses similarities and differences between keywords, disciplines, authors and regions and identifies obvious clusters. Assessing their commonalities and differences, the visualisation of links and gaps between scientists, organisations, policymakers and other stakeholders is possible. The interpretation of the 'clouds' of disciplines, keywords, and techniques will enhance the understanding of interconnections between them; ultimately this will allow diagnosing some of their strengths and weaknesses. This may help explain why land and soil degradation remains a serious global problem that lacks sufficient attention. We hope that this study will contribute to clarify the scientific landscape at stake to remediate possible weaknesses in the future.

Escadafal, Richard; Barbero, Celia; Exbrayat, Williams; Marques, Maria Jose; Ruiz, Manuel; El Haddadi, Anass; Akhtar-Schuster, Mariam



Finding and Managing Information: Generic Information Literacy and Management Skills for Postgraduate Researchers  

E-print Network

A gap in the linking of information literacy skills and bibliographic software usage was identified in the postgraduate researcher cohort. While the provision was available, many researchers were not integrating the finding of research information...

Heading, David; Siminson, Nicola; Purcell, Christine; Pears, Richard



42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.  

Code of Federal Regulations, 2011 CFR

... 2011-10-01 false Findings of research misconduct and proposed administrative...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.404...



42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.  

Code of Federal Regulations, 2011 CFR

...HHS action with settlement or finding of research misconduct. 93.411 Section 93...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.411...



42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.  

Code of Federal Regulations, 2010 CFR

... 2010-10-01 false Findings of research misconduct and proposed administrative...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.404...



42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.  

Code of Federal Regulations, 2010 CFR

...HHS action with settlement or finding of research misconduct. 93.411 Section 93...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.411...



42 CFR 93.411 - Final HHS action with settlement or finding of research misconduct.  

Code of Federal Regulations, 2014 CFR

...HHS action with settlement or finding of research misconduct. 93.411 Section 93...FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the...Department of Health and Human Services Research Misconduct Issues § 93.411...



Incorporating Research Findings into Standards and Requirements for Space Medicine  

NASA Technical Reports Server (NTRS)

The Vision for Exploration has been the catalyst for NASA to refocus its life sciences research. In the future, life sciences research funded by NASA will be focused on answering questions that directly impact setting physiological standards and developing effective countermeasures to the undesirable physiological and psychological effects of spaceflight for maintaining the health of the human system. This, in turn, will contribute to the success of exploration class missions. We will show how research will impact setting physiologic standards, such as exposure limits, outcome limits, and accepted performance ranges. We will give examples of how a physiologic standard can eventually be translated into an operational requirement, then a functional requirement, and eventually spaceflight hardware or procedures. This knowledge will be important to the space medicine community as well as to vehicle contractors who, for the first time, must now consider the human system in developing and constructing a vehicle that can achieve the goal of success.

Duncan, J. Michael



Scoping the Field: Identifying Key Research Priorities in HIV and Rehabilitation  

Microsoft Academic Search

The purpose of this project was to identify key research priorities related to HIV and rehabilitation. We conducted a scoping\\u000a study which included a literature review of published and grey literature, followed by focus group and interview consultations\\u000a with 28 participants including people living with HIV, researchers, educators, clinicians, and policy makers with expertise\\u000a in HIV and rehabilitation. Qualitative content

Kelly O’Brien; Annette Wilkins; Elisse Zack; Patricia Solomon



Dental Laboratory Technology. Project Report Phase I with Research Findings.  

ERIC Educational Resources Information Center

This report provides results of Phase I of a project that researched the occupational area of dental laboratory technology, established appropriate committees, and conducted task verification. These results are intended to guide development of a program designed to train dental laboratory technicians. Section 1 contains general information:…

Sappe', Hoyt; Smith, Debra S.


A Normative Study of Children's Drawings: Preliminary Research Findings  

ERIC Educational Resources Information Center

This paper describes methodology, data analysis, and initial results of a research study with the long-term goal of establishing contemporary normative data on drawings from children living in the United States. The pool of participants was composed of 316 fourth graders (mean age 9.69 years) and 151 second graders (mean age 7.56 years) who each…

Deaver, Sarah P.



Research on Tactual Communication of Speech: Ideas, Issues, and Findings.  

ERIC Educational Resources Information Center

This research review on tactual communication of speech discusses methods of communication intended for the tactual sense alone, issues related to tactual input as a supplement for speechreading, and issues related to developing new synthetic tactual aids and the roles such aids could play in treating people with profound hearing loss. (Author/JDD)

Reed, Charlotte M.; And Others



Urban Delinquency and Substance Abuse. Initial Findings. Research Summary.  

ERIC Educational Resources Information Center

In collaborative efforts three research teams have investigated the problems of urban delinquency and substance abuse in longitudinal studies that have gone on since 1986. The Denver Youth Study is a longitudinal survey that involves annual interviews with probability samples of five different birth cohorts and their parents from areas of Denver…

Huizinga, David; Loeber, Rolf; Thornberry, Terence P.


Youth Sports: Implementing Findings and Moving Forward with Research  

Microsoft Academic Search

This paper reviews the literature, outlines practical implications, and discusses future studies in youth sport research. The literature is discussed in light of three potential benefits of youth sport participation 1) physical health, 2) psycho-social development, and 3) motor skills acquisition. The ultimate objective of youth sport programs is to consider all the benefits of youth sport participation rather than

Jessica Fraser-Thomas; Jean Côté


Conducting research Training scientists Finding applications Sharing knowledge and resources  

E-print Network

are working on issues of major global importance today: global warming, emerging diseases, biodiversity with universities and other research bodies. This allows us to mobilise a wealth of scientific and human potential to study problems of importance for Southern countries. This potential was further strengthened by two new


Vanderbilt researchers find that an enzyme affects tumor metastasis

Researchers have established a role for MMP2 in the development of lung metastases from primary breast cancer. Using mice without the Mmp2 gene, the team found that metastatic tumors in the lung proliferate less in the absence of fibroblast MMP2.


Research on Interest in Science: Theories, Methods, and Findings  

ERIC Educational Resources Information Center

This article presents an overview of interest research and describes the theoretical and methodological background for the assessment of interest in science in large-scale assessments like the "Programme for International Student Assessment" (PISA). The paper starts with a short retrospective on the history of interest, bringing out theoretical…

Krapp, Andreas; Prenzel, Manfred



Researchers Find That Childhood Sarcoma Increases Risk of Blood Clots

Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, have determined that children and young adults with a form of cancer called sarcoma are at increased risk of having a thromboembolic event (TE) in their veins.


UT Southwestern researchers find new gene mutations for Wilms Tumor

Researchers at UT Southwestern Medical Center and the Gill Center for Cancer and Blood Disorders at Children’s Medical Center, Dallas, have made significant progress in defining new genetic causes of Wilms tumor, a type of kidney cancer found only in children.



EPA Science Inventory

Investigators often misapply quality assurance (QA) procedures and may consider QA as a hindrance to developing test plans for sampling and analysis. If used properly, however, QA is the driving force for collecting the right kind and proper amount of data. Researchers must...



EPA Science Inventory

Investigators often misapply quality assurance (QA) procedures and may consider QA as a hindrance to developing test plans for sampling and analysis. If used properly, however, QA is the driving force for collecting the right kind and proper amount of data. Researchers must use Q...


PRIMARY RESEARCH PAPER Is salinity tolerance the key to success for the invasive water  

E-print Network

PRIMARY RESEARCH PAPER Is salinity tolerance the key to success for the invasive water bug) that occurs in brackish and saline aquatic systems. Recently, it has been found invading three continents compared both the realized and standardized salinity niche of invasive T. verticalis and native Corixidae

Green, Andy J.


Research on the key technology of smart substation model configuration and check  

Microsoft Academic Search

Currently, smart substation is the hot research. This paper mainly studies the key technology of IEC 61850-based smart substation model configuration and check, solving the urgent problems of primary and secondary equipment model configuration and model check about substation. Firstly, this paper simply presents the characteristics of smart substation, analyzing the primary and secondary equipment model configuration. By comparing the

HaiDong Zhang; AiLin Chen; Min NiYi; Jie Ding



Good Research and Faculty Buy-in: 2 Keys to Effective Marketing  

ERIC Educational Resources Information Center

Effective marketing requires more than a sleek new logo. This article presents excerpts of an online discussion on the dos and don'ts of college marketing with Mary R. Stagaman, associate vice president for external relations at the University of Cincinnati. In this discussion, she noted that good research and faculty buy-in are the two keys to…

Blumenstyk, Goldie



Research Findings on Radiation Hormesis and Radon Therapy  

SciTech Connect

Radiation hormesis research in Japan to determine the validity of Luckey's claims has revealed information on the health effects of low-level radiation. The scientific data of animal tests we obtained and successful results actually brought by radon therapy on human patients show us a clearer understanding of the health effects of low-level radiation. We obtained many animal test results and epidemiological survey data through our research activities cooperating with more than ten universities in Japan, categorized as follows: 1. suppression of cancer by enhancement of the immune system based on gene activation; 2. rejuvenation and suppression of aging by increasing cell membrane permeability and enzyme syntheses; 3. adaptive response by activation of gene expression on DNA repair and cell apoptosis; 4. pain relief and stress moderation by hormone formation in the brain and central nervous system; 5. avoidance and therapy of obstinate diseases by enhancing damage control systems and form one formation.

Hattori, Sadao



Pain, Nicotine, and Smoking: Research Findings and Mechanistic Considerations  

PubMed Central

Tobacco addiction and chronic pain represent two highly prevalent and comorbid conditions that engender substantial burdens upon individuals and systems. Although interrelations between pain and smoking have been of clinical and empirical interest for decades, research on the topic of pain, nicotine, and tobacco smoking has increased dramatically over the past five years. We conceptualize the interaction of pain and smoking as a prototypical example of the biopsychosocial model. Accordingly, the current review extrapolated from behavioral, cognitive, affective, biomedical, and social perspectives to propose causal mechanisms that may contribute to the observed comorbidity between these two conditions. Research in the broad area of pain and smoking was first dichotomized into investigations of either "effects of smoking on pain" or "effects of pain on smoking." We then integrated the extant literature to present a reciprocal model of pain and smoking that is hypothesized to interact in the manner of a positive feedback loop, resulting in greater pain, increased smoking, and the maintenance of tobacco addiction. Finally, we proposed directions for future research, and discussed clinical implications for smokers with comorbid pain disorders. We observed modest evidence to support the notions that smoking may be a risk factor in the multifactorial etiology of some chronically painful conditions, and that the experience of pain may come to serve as a potent motivator of smoking. We also found that whereas animal studies yielded consistent support for direct pain-inhibitory effects of nicotine and tobacco smoke, results from human studies were much less consistent. Future research in the emerging area of pain and smoking has the potential to inform theoretical and clinical applications with respect to tobacco smoking, chronic pain, and their comorbid presentation. PMID:21967450

Ditre, Joseph W.; Brandon, Thomas H.; Zale, Emily L.; Meagher, Mary M.



Research team finds a new breast cancer susceptibility gene

A team of researchers led by co-principal investigators from the Hunstman Cancer Institute, the University of Utah, and the University of Melbourne, Australia, have found that mutations in a gene called XRCC2 cause increased breast cancer risk, according to a study published online in the American Journal of Human Genetics. The study looked at families that have a history of the disease but do not have mutations in the currently known breast cancer susceptibility genes.


Findings of the US Research Needs Workshop on the Topic of Fusion Power  

SciTech Connect

The US Department of Energy, Office of Fusion Energy Sciences (OFES) conducted a Research Needs Workshop, referred to as ReNeW, in June 2009. The information developed at this workshop will help OFES develop a plan for US fusion research during the ITER era, roughly the next two decades. The workshop was organized in five Themes, one of which was Harnessing Fusion Power (or Fusion Power for short). The top level goal of the Fusion Power Theme was to identify the research needed to develop the knowledge to design and build, with high confidence, robust and reliable systems that can convert fusion products to useful forms of energy in a reactor environment, including a self-sufficient supply of tritium fuel. Each Theme was subsequently subdivided into Panels to address specific topics. The Fusion Power Panel topics were: fusion fuel cycle; power extraction; materials science; safety and environment; and reliability, availability, maintainability and inspectability (RAMI). Here we present the key findings of the Fusion Power Theme.

Meier, W R; Raffray, A R; Kurtz, R J; Morley, N B; Reiersen, W T; Sharpe, P; Willms, S



Findings of the US research needs workshop on the topic of fusion power  

SciTech Connect

The US Department of Energy, Office of Fusion Energy Sciences (OFES) conducted a Research Needs Workshop, referred to as ReNeW, in June 2009. The information developed at this workshop will help OFES develop a plan for US fusion research during the ITER era, roughly the next two decades. The workshop was organized in five Themes, one of which was Harnessing Fusion Power (or Fusion Power for short). The top level goal of the Fusion Power Theme was to identify the research needed to develop the knowledge to design and build, with high confidence, robust and reliable systems that can convert fusion products to useful forms of energy in a reactor environment, including a self-sufficient supply of tritium fuel. Each Theme was subsequently subdivided into Panels to address specific topics. The Fusion Power Panel topics were: Fusion Fuel Cycle; Power Extraction; Materials Science; Safety and Environment; and Reliability, Availability, Maintainability and Inspectability (RAMI). Here we present the key findings of the Fusion Power Theme.

W. R. Meier; A. R. Raffray; R. J. Kurtz; N. B. Morley; W. T. Reiersen; Phil Sharpe; S. Willms



Gate valve and motor-operator research findings  

SciTech Connect

This report provides an update on the valve research being sponsored by the US Nuclear Regulatory Commission (NRC) and conducted at the Idaho National Engineering Laboratory (INEL). The research addresses the need to provide assurance that motor-operated valves can perform their intended safety function, usually to open or close against specified (design basis) flow and pressure loads. This report describes several important developments: Two methods for estimating or bounding the design basis stem factor (in rising-stem valves), using data from tests less severe than design basis tests; a new correlation for evaluating the opening responses of gate valves and for predicting opening requirements; an extrapolation method that uses the results of a best effort flow test to estimate the design basis closing requirements of a gate valve that exhibits atypical responses (peak force occurs before flow isolation); and the extension of the original INEL closing correlation to include low- flow and low-pressure loads. The report also includes a general approach, presented in step-by-step format, for determining operating margins for rising-stem valves (gate valves and globe valves) as well as quarter-turn valves (ball valves and butterfly valves).

Steele, R. Jr.; DeWall, K.G.; Watkins, J.C.; Russell, M.J.; Bramwell, D.



Remote ergonomic research in space: spacelab findings and a proposal.  


This paper discusses ergonomics research using remotely situated video cameras in spacecraft. Two prototype studies of crewmembers working in the micro-G environments aboard the first two flights of Spacelab are described. Various aspects of crew restraint, stabilization, manipulation of controls, and mobilization were observed, operationally defined, and quantified by observing videotaped scenes of Spacelab crewmembers. In the first study, four performance behaviors were quantified to provide estimates of their frequency of occurrence and variation over the course of each of the flights. The behaviors and their mean percent of observed times were: Hand-Hold 32.2%, Foot Restraint 35.3%, Translation 9.4%, and Struggle 3.7%. Because we observed that nearly a third of a crewmember's time was spent inefficiently holding on with one hand while trying to work with the other, a second study was conducted exploring the use of foot restraints and hand stabilization. During 18 episodes of single-foot restraint, for example, there were 52 instances of hand stabilization and 135 instances of stabilization attempts with the other foot. The paper concludes with some defining characteristics of adequate foot restraints, and a proposal for extending this research model to future spacecraft studies. PMID:8834945

Wichman, H A; Donaldson, S I



Research based empathic knowledge for nursing: A translational strategy for disseminating phenomenological research findings to provide evidence for caring practice  

Microsoft Academic Search

We are interested in the kind of knowledge that is particularly relevant to caring practice and the way in which qualitative research findings can serve such knowledge. As phenomenological researchers we have been engaged with the question of how findings from such research can be re-presented and expressed more aesthetically. Such a movement towards a more aesthetic phenomenology may serve

Kathleen T. Galvin; Les Todres



Oersted Medal Lecture 2001: "Physics Education Research-The Key to Student Learning"  

NSDL National Science Digital Library

Research on the learning and teaching of physics is essential for cumulative improvement in physics instruction. Pursuing this goal through systematic research is efficient and greatly increases the likelihood that innovations will be effective beyond a particular instructor or institutional setting. The perspective taken is that teaching is a science as well as an art. Research conducted by physicists who are actively engaged in teaching can be the key to setting high (yet realistic) standards, to helping students meet expectations, and to assessing the extent to which real learning takes place.

Mcdermott, Lillian C.



Bioethanol from Lignocellulosic Biomass: Current Findings Determine Research Priorities  

PubMed Central

“Second generation” bioethanol, with lignocellulose material as feedstock, is a promising alternative for first generation bioethanol. This paper provides an overview of the current status and reveals the bottlenecks that hamper its implementation. The current literature specifies a conversion of biomass to bioethanol of 30 to ~50% only. Novel processes increase the conversion yield to about 92% of the theoretical yield. New combined processes reduce both the number of operational steps and the production of inhibitors. Recent advances in genetically engineered microorganisms are promising for higher alcohol tolerance and conversion efficiency. By combining advanced systems and by intensive additional research to eliminate current bottlenecks, second generation bioethanol could surpass the traditional first generation processes. PMID:25614881

Kang, Qian; Appels, Lise; Tan, Tianwei



New Research Findings on Emotionally Focused Therapy: Introduction to Special Section  

ERIC Educational Resources Information Center

This article introduces the special section "New Research Findings on Emotionally Focused Therapy." Emotionally focused couple therapy researchers have a strong tradition of outcome and process research and this special section presents new findings from three recent studies. The first study furthers the goal of determining the kinds of clients…

Johnson, Susan M.; Wittenborn, Andrea K.



Exploiting multimedia in reproductive science education: research findings.  


Education in reproductive science is operating from an outdated paradigm of teaching and learning. Traditionally, reproductive education follows the pattern where students read a textbook, listen to instructor presentations, re-read the textbook and class notes and then complete a test. This paradigm is inefficient, costly and has not incorporated the potential that technology can offer with respect to increases in student learning. Further, teachers of reproductive science (and all of science for that matter) have little training in the use of documented methods of instructional design and cognitive psychology. Thus, most of us have learned to teach by repeating the approaches our mentors used (both good and bad). The technology now exists to explain complex topics using multimedia presentations in which digital animation and three-dimensional anatomical reconstructions greatly reduce time required for delivery while at the same time improving student understanding. With funding from the Small Business Innovation Research program through the U.S. Department of Education, we have developed and tested a multimedia approach to teaching complex concepts in reproductive physiology. The results of five separate experiments involving 1058 university students and 122 patients in an OB/GYN clinic indicate that students and patients learned as much or more in less time when viewing the multimedia presentations when compared to traditional teaching methodologies. PMID:22827348

Senger, P L; Oki, A C; Trevisan, M S; McLean, D J



Researching the meaning of life: finding new sources of hope.  


The purpose of the paper is to discuss means of assisting terminally ill patients in seeking for sources of meaning and hope, alongside the acknowledgment that their lifespan is short.Psycho-spiritual aspects make a substantial component patients suffering from incurable illness have to deal with. Evaluating and mapping the causes and expressions of psychological--spiritual suffering may assist in tailoring appropriate strategies of distress relief. Therefore, interventions should be given in accordance with their specific focus of difficulties, as well as with wishes and needs. Appropriate interventions in palliative psychotherapeutic rapport are inspired by identifying new sources for meaning in current life (sometimes, aided by past experiences or future visions). Reinforcing sources for meaning may attempt in providing patients amongst:--equilibrium, between suffering and sorrow (which sometimes take over the patient's world), and on the other hand, new experiences, sense of satisfaction and fulfillment. Individual's acknowledgment that he is not completely withdrawn from the circle of life, and yet significance and fulfillment in life still exists. For a holistic meaning ? centered intervention it is advisable to simultaneously integrate two central axes: the existential analysis, inspired by concepts driven from Frenkl's Logotherapy, such as freedom of choice, personal responsibility, inner truth, hope and transcendentalism; the operative axis, enhancing meaning and hope by assisting patient's wishes come true. Patients are aware, many times, that those wishes may be their last one, therefore perceive their fulfillment as crucial for their sense of meaning. Moreover, those wishes may elevate patient and family's spirit and reduce risk of demoralization. Whereas existential--spiritual interventions are recommended to be given by qualified professional therapists, the operation of fulfilling wishes is feasible by everyone, from family members to multi-disciplinary staff. Case illustrations for meaning--centered interventions will be discussed in the course of the paper. Cultural and traditional differences within the Israeli society, expressed in themes of work with patients, will lead to the conclusion, that there are many creative ways for researching meaning of life and sources for hope. PMID:20590354

Alon, Shirly



Recommendations for sex/gender neuroimaging research: key principles and implications for research design, analysis, and interpretation.  


Neuroimaging (NI) technologies are having increasing impact in the study of complex cognitive and social processes. In this emerging field of social cognitive neuroscience, a central goal should be to increase the understanding of the interaction between the neurobiology of the individual and the environment in which humans develop and function. The study of sex/gender is often a focus for NI research, and may be motivated by a desire to better understand general developmental principles, mental health problems that show female-male disparities, and gendered differences in society. In order to ensure the maximum possible contribution of NI research to these goals, we draw attention to four key principles-overlap, mosaicism, contingency and entanglement-that have emerged from sex/gender research and that should inform NI research design, analysis and interpretation. We discuss the implications of these principles in the form of constructive guidelines and suggestions for researchers, editors, reviewers and science communicators. PMID:25221493

Rippon, Gina; Jordan-Young, Rebecca; Kaiser, Anelis; Fine, Cordelia



Study led by St. Jude finds key regulatory genes often amplified in aggressive childhood tumor of the brainstem:

The largest study ever of a rare childhood brain tumor found more than half the tumors carried extra copies of specific genes linked to cancer growth, according to research led by St. Jude Children’s Research Hospital investigators.


Key Findings www.npc.umich.eduGerald R. Ford School of Public Policy, University of Michigan  

E-print Network

be a link on the pathway between these factors and subsequent health problems, rather than a cause itself, March 2012 Policy Brief The National Poverty Center's Policy Brief series summarizes key academic. Sample citation: "Title, National Poverty Center Policy Brief #x". Housing Instability and Health

Edwards, Paul N.


Anthropomorphic Agents as a User Interface Paradigm: Experimental Findings and a Framework for Research  

Microsoft Academic Search

Research on anthropomorphic agent interfaces has produced widely divergent results. We suggest that this is due to insufficient consideration of key factors that influence the perception and effectiveness of agent-based interfaces. We propose a framework for studying anthropomorphic agents that can systematize the research. The framework emphasizes features of the agent, the user, and the task the user is performing.

Richard Catrambone


Twenty-six key research questions in urban stream ecology: an assessment of the state of the science  

EPA Science Inventory

Although urban streams have been the focus of much research activity in recent years, there remain many unanswered questions about the mechanisms driving the ?urban stream syndrome.? Identification of these key research questions is an important step toward effective, efficient ...


Recent research related to juvenile sex offending: findings and directions for further research.  


Serious scholarly inquiry into juvenile sex offending represents a relatively new field, dating from the mid 1940s. During the next 4 decades, a mere handful of articles exploring aspects of juvenile sex offending were added to the available literature. By the 1980s, however, the literature began to increase rapidly, a trend that continues today. The purpose of this article is a focused review of the juvenile sex offender literature cited in PubMed over the last 5 years (2009-2013). The authors have chosen studies that will bring readers up to date on research they believe impacts our current understanding of best practices in the management of juvenile sex offending. For convenience, our review is organized into topical categories including research into characteristics and typologies of juvenile sex offenders, risk assessment and recidivism, assessment and treatment, the ongoing debate about mandatory registration of sex offenders as it applies to juveniles, and other thought provoking studies that do not fit neatly into the aforementioned categories. The studies included contain findings that both reinforce and challenge currently held notions about best practices concerning treatment and public policy, suggesting that our knowledge of the field continues to evolve in important ways. PMID:24562765

Malin, H Martin; Saleh, Fabian M; Grudzinskas, Albert J



Fox Chase analysis finds more cutting-edge cancer research supported by industry

Nearly half of the research presented at ASCO’s annual meeting last year came from researchers with ties to companies, and the amount appears to be increasing every year, according to new findings from Fox Chase Cancer Center. The new findings will be presented this year at the 2012 American Society of Clinical Oncology Annual Meeting on Monday, June 4.


Monitoring the Future. National Results on Adolescent Drug Use: Overview of Key Findings, 2009. NIH Publication Number 10-7583  

ERIC Educational Resources Information Center

Monitoring the Future (MTF) is a long-term study of American adolescents, college students, and adults through age 50. It has been conducted annually by the University of Michigan's Institute for Social Research since its inception in 1975. It is supported under a series of investigator-initiated, competing research grants from the National…

Johnston, Lloyd D.; O'Malley, Patrick M.; Bachman, Jerald G.; Schulenberg, John E.



Monitoring the Future: National Results on Adolescent Drug Use. Overview of Key Findings, 2009. NIH Publication No. 10-7583  

ERIC Educational Resources Information Center

Monitoring the Future (MTF) is a long-term study of American adolescents, college students, and adults through age 50. It has been conducted annually by the University of Michigan's Institute for Social Research since its inception in 1975. It is supported under a series of investigator-initiated, competing research grants from the National…

Johnston, Lloyd D.; O'Malley, Patrick M.; Bachman, Jerald G.; Schulenberg, John E.



Racial and Ethnic Disparities: Key Findings from the National Survey of America's Families. Series B, No. B-5.  

ERIC Educational Resources Information Center

This brief outlines findings from the National Survey of America's Families, a survey of 44,461 households, on 7 indicators of well-being by race and ethnicity: poverty, family structure, child support, food hardship, housing hardship, health status, and health insurance coverage. For the purpose of this brief, all persons of Hispanic origin were…

Staveteig, Sarah; Wigton, Alyssa


Anthropomorphic Agents as a UI Paradigm: Experimental Findings and a Framework for Research  

E-print Network

Anthropomorphic Agents as a UI Paradigm: Experimental Findings and a Framework for,, Abstract Research on anthropomorphic agent propose a framework for studying anthropomorphic agents that can systematize the research. The framework

Stasko, John T.


Theme: Research Findings--Using What We Know to Improve Teaching and Learning.  

ERIC Educational Resources Information Center

Seven theme articles explore use of research findings to enhance agricultural education (including supervised agricultural experience and Future Farmers of America research), teaching for higher level cognition in adult education, using research to plan curriculum, and improving leadership development in agricultural student organizations. (SK)

Cheek, Jimmy G.; And Others



Do Researchers Have an Obligation to Actively Look for Genetic Incidental Findings?  

PubMed Central

The rapid growth of next-generation genetic sequencing has prompted debate about the responsibilities of researchers toward genetic incidental findings. Assuming there is a duty to disclose significant incidental findings, might there be an obligation for researchers to actively look for these findings? We present an ethical framework for analyzing whether there is a positive duty to look for genetic incidental findings. Using the ancillary care framework as a guide, we identify three main criteria that must be present to give rise to an obligation to look: high benefit to participants, lack of alternative access for participants, and reasonable burden on researchers. Our analysis indicates that there is no obligation to look for incidental findings today, but during the ongoing translation of genomic analysis from research to clinical care, this obligation may arise. PMID:23391059

Gliwa, Catherine; Berkman, Benjamin E.



Preliminary Findings of Learning Gains for Adult Learners with Developmental Disabilities. Research Brief No. 6  

ERIC Educational Resources Information Center

Public perception of adults with developmental disabilities realizing learning gains often remains illusive. This paper highlights key findings in achievement in basic skills for adults with mental retardation on a functional assessment in a life skills context for three program years (2003-2006). In this study the time period between the pre- and…

Posey, Virginia; Jacobsen, Jared



Breast Cancer Highlights: Key Findings from the San Antonio Breast Cancer Symposium: A U.S. Perspective  

Microsoft Academic Search

The San Antonio Breast Cancer Symposium has become one of the leading forums for communication of important discoveries in breast cancer research. Over the past couple of years, seminal, practice-changing results have been presented at this meeting. The aromatase inhibitors represent the most effective endocrine interven- tions for postmenopausal women with hormone receptor- positive breast cancer. Their introduction into the



Sharing the Knowledge: Sharing Aggregate Genomic Findings with Research Participants in Developing Countries.  


Returning research results to participants is recognised as an obligation that researchers should always try to fulfil. But can we ascribe the same obligation to researchers who conduct genomics research producing only aggregated findings? And what about genomics research conducted in developing countries? This paper considers Beskow's et?al. argument that aggregated findings should also be returned to research participants. This recommendation is examined in the context of genomics research conducted in developing countries. The risks and benefits of attempting such an exercise are identified, and suggestions on ways to avoid some of the challenges are proposed. I argue that disseminating the findings of genomic research to participating communities should be seen as sharing knowledge rather than returning results. Calling the dissemination of aggregate, population level information returning results can be confusing and misleading as participants might expect to receive individual level information. Talking about sharing knowledge is a more appropriate way of expressing and communicating the outcome of population genomic research. Considering the knowledge produced by genomics research a worthwhile output that should be shared with the participants and approaching the exercise as a 'sharing of knowledge', could help mitigate the risks of unrealistic expectations and misunderstanding of findings, whilst promoting trusting and long lasting relationships with the participating communities. PMID:25292263

Kerasidou, Angeliki




PubMed Central

Internationally, calls for feedback of findings to be made an ‘ethical imperative’ or mandatory have been met with both strong support and opposition. Challenges include differences in issues by type of study and context, disentangling between aggregate and individual study results, and inadequate empirical evidence on which to draw. In this paper we present data from observations and interviews with key stakeholders involved in feeding back aggregate study findings for two Phase II malaria vaccine trials among children under the age of 5 years old on the Kenyan Coast. In our setting, feeding back of aggregate findings was an appreciated set of activities. The inclusion of individual results was important from the point of view of both participants and researchers, to reassure participants of trial safety, and to ensure that positive results were not over-interpreted and that individual level issues around blinding and control were clarified. Feedback sessions also offered an opportunity to re-evaluate and re-negotiate trial relationships and benefits, with potentially important implications for perceptions of and involvement in follow-up work for the trials and in future research. We found that feedback of findings is a complex but key step in a continuing set of social interactions between community members and research staff (particularly field staff who work at the interface with communities), and among community members themselves; a step which needs careful planning from the outset. We agree with others that individual and aggregate results need to be considered separately, and that for individual results, both the nature and value of the information, and the context, including social relationships, need to be taken into account. PMID:23433355

Gikonyo, Caroline; Kamuya, Dorcas; Mbete, Bibi; Njuguna, Patricia; Olotu, Ally; Bejon, Philip; Marsh, Vicki; Molyneux, Sassy



Building a Successful Adult Life: Findings from Youth-Directed Research  

ERIC Educational Resources Information Center

Although transition outcomes for youth with disabilities have shown some improvement and transition support practices have been identified, many young people continue to face transition barriers that preclude their full participation in key adult life activities. While research efforts have largely been professionally driven, there is emerging…

Powers, Laurie E.; Garner, Tracee; Valnes, Betsy; Squire, Peter; Turner, Alison; Couture, Todd; Dertinger, Rocky



Cost-effectiveness analysis and formulary decision making in England: Findings from research  

Microsoft Academic Search

In a context of rapid technological advances in health care and increasing demand for expensive treatments, local formulary committees are key players in the management of scarce resources. However, little is known about the information and processes used when making decisions on the inclusion of new treatments. This paper reports research on the use of economic evaluations in technology coverage

Iestyn P. Williams; Stirling Bryan



A Visitor's Guide to Effect Sizes – Statistical Significance Versus Practical (Clinical) Importance of Research Findings  

Microsoft Academic Search

Effect Sizes (ES) are an increasingly important index used toquantify the degree of practical significanceof study results. This paper gives anintroduction to the computation andinterpretation of effect sizes from theperspective of the consumer of the researchliterature. The key points made are:1. ES is a useful indicator of the practical(clinical) importance of research resultsthat can be operationally defined frombeing ``negligible'' to

Mohammadreza Hojat; Gang Xu



NIH Researchers Find Resveratrol Helps Protect against Cardiovascular Disease in Animal Study  


NIH researchers find Resveratrol helps protect against cardiovascular disease in animal study June 3, 2014 Resveratrol, a compound found in nuts, grapes, and wine, may protect against certain cardiovascular problems, according to ...


Alcohol Use Disorders, Research Findings | NIH MedlinePlus the Magazine  


... of this page please turn Javascript on. Feature: Alcohol Use and Abuse Alcohol Use Research Findings Past Issues / Winter 2013 Table ... and adolescents years after they were exposed to alcohol in the womb. That is according to a ...


U of Minnesota researchers find that microRNA is tied to colon cancer tumor growth

Researchers have identified microRNAs that may cause colon polyps from turning cancerous. The finding could help physicians provide more specialized, and earlier, treatment before colon cancer develops.


Researcher Tales and Research Ethics: The Spaces in Which We Find Ourselves  

ERIC Educational Resources Information Center

The tales we tell here focus on the ethical issues arising from our research practice with vulnerable young participants and those for whom research has been inextricably linked with European imperialism and colonialism. The importance of relational obligations, temporality and potential for a continuing narrative approach to ethical research

White, Julie; Fitzgerald, Tanya



A Transdisciplinary Approach to Training: Preliminary Research Findings Based on a Case Analysis  

ERIC Educational Resources Information Center

Purpose: The purpose of this paper is to discuss the benefits, barriers and challenges of the transdisciplinary approach to training, and to present findings of a case analysis. Design/methodology/approach: The paper is based on the research findings of an experimental training program for Greek local government managers co-funded by the European…

Bimpitsos, Christos; Petridou, Eugenia



School Effectiveness Research Findings in the Portuguese Speaking Countries: Brazil and Portugal  

ERIC Educational Resources Information Center

This paper provides findings of research on school effectiveness and discusses implications for evaluation in Brazil and Portugal. Most findings reported over the last decade have been published in Brazilian or Portuguese refereed journals. Thus, a brief literature review of such studies enables that knowledge to reach international scholars and…

Ferrão, Maria Eugénia



Industry and Labour Market Research Labour market and industry research are key components of the career planning process. When engaging in career  

E-print Network

Industry and Labour Market Research Labour market and industry research are key components occupational research. Conducting labour market and industry research can also assist you with preparing understanding of the labour market and specific knowledge about industry sectors to supplement your

Boonstra, Rudy


Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science  

PubMed Central

Background Many interventions found to be effective in health services research studies fail to translate into meaningful patient care outcomes across multiple contexts. Health services researchers recognize the need to evaluate not only summative outcomes but also formative outcomes to assess the extent to which implementation is effective in a specific setting, prolongs sustainability, and promotes dissemination into other settings. Many implementation theories have been published to help promote effective implementation. However, they overlap considerably in the constructs included in individual theories, and a comparison of theories reveals that each is missing important constructs included in other theories. In addition, terminology and definitions are not consistent across theories. We describe the Consolidated Framework For Implementation Research (CFIR) that offers an overarching typology to promote implementation theory development and verification about what works where and why across multiple contexts. Methods We used a snowball sampling approach to identify published theories that were evaluated to identify constructs based on strength of conceptual or empirical support for influence on implementation, consistency in definitions, alignment with our own findings, and potential for measurement. We combined constructs across published theories that had different labels but were redundant or overlapping in definition, and we parsed apart constructs that conflated underlying concepts. Results The CFIR is composed of five major domains: intervention characteristics, outer setting, inner setting, characteristics of the individuals involved, and the process of implementation. Eight constructs were identified related to the intervention (e.g., evidence strength and quality), four constructs were identified related to outer setting (e.g., patient needs and resources), 12 constructs were identified related to inner setting (e.g., culture, leadership engagement), five constructs were identified related to individual characteristics, and eight constructs were identified related to process (e.g., plan, evaluate, and reflect). We present explicit definitions for each construct. Conclusion The CFIR provides a pragmatic structure for approaching complex, interacting, multi-level, and transient states of constructs in the real world by embracing, consolidating, and unifying key constructs from published implementation theories. It can be used to guide formative evaluations and build the implementation knowledge base across multiple studies and settings. PMID:19664226

Damschroder, Laura J; Aron, David C; Keith, Rosalind E; Kirsh, Susan R; Alexander, Jeffery A; Lowery, Julie C



Human Microbiome Project Researchers Find Vast Individual Differences in Our Bacteria  

E-print Network

Human Microbiome Project Researchers Find Vast Individual Differences in Our Bacteria When by NIH, the Human Microbiome Project (HMP) has announced first genomic compilation of the generalized that carry out metabolic activities, researchers estimate that the microbiome contributes some 8 million

Howitt, Ivan


Communicating pesticide neurotoxicity research findings and risks to decision-makers and the public.  


The extensive research findings on neurotoxic risks of pesticides tend to remain in academic publications rather than being comprehensibly communicated to decision-makers and the public. Protecting health and promoting risk reduction, particularly in developing countries, requires access to current findings in a format that can inform policy, regulations, behaviour change and risk reduction. Successfully communicating research findings may require multiple strategies depending on the target audience's varying comprehension skills (e.g., numeracy literacy, visual literacy) and ability to interpret scientific data. To illustrate the complexities of risk communication, a case study of exposure to neurotoxic street pesticides amongst poor, urban South African communities attempting to control poverty related pests, is presented. What remains a challenge is how to communicate neurotoxicity research findings consistently and in a meaningful manner for a lay audience, consisting of both the general public and decision makers. A further challenge is to identify who will monitor and evaluate the ways in which these findings are communicated to ensure quality is maintained. Ultimately, researchers should carry the responsibility of knowledge translation and engaging with communication specialists when appropriate. Additionally, institutions should reward this as part of promotion and academic accolade systems, and funders should fund the translational process. Ethics review boards should also play an instrumental role in ensuring that knowledge translation is part of the ethics review requirement, while professional societies should take more responsibility for disseminating research findings to non-academics. PMID:24642183

Rother, Hanna-Andrea



Key research issues in the pulsed fast-neutron analysis technique for cargo inspection  

SciTech Connect

Non-invasive inspection systems based on the use of fast neutrons are being studied for the inspection of large cargo containers. A key advantage of fast neutrons is their sensitivity to low-Z elements such as carbon, nitrogen, and oxygen, which are the primary constituents of explosives and narcotics. The high energy allows penetration of relatively large containers. The pulsed fast-neutron analysis (PFNA) technique is currently the baseline system. A workshop on the PFNA technique involving industrial, government, and university participants was held at Argonne National Lab. in January 1994. The purpose of this workshop was to review the status of research on the key technical issues involved in PFNA, and to develop a list of those areas where additional modeling and/or experimentation were needed. The workshop also focused on development of a near-term experimental assessment program using existing prototypes and on development of a long-term test program at the Tacoma Testbed, where a PFNA prototype will be installed in 1995. A summary of conclusions reached at this workshop is presented. Results from analytic and Monte Carlo modeling of simplified PFNA systems are also presented.

Micklich, B.J.; Fink, C.L.; Yule, T.J.



Key research issues in the pulsed fast-neutron analysis technique for cargo inspection  

NASA Astrophysics Data System (ADS)

Non-invasive inspection systems based on the use of fast neutrons are being studied for the inspection of large cargo containers. A key advantage of fast neutrons is their sensitivity to low-Z elements such as carbon, nitrogen, and oxygen, which are the primary constituents of explosives and narcotics. The high energy allows penetration of relatively large containers. The pulsed fast-neutron analysis (PFNA) technique is currently the baseline system. A workshop on the PFNA technique involving industrial, government, and university participants was held at Argonne National Laboratory in January 1994. The purpose of this workshop was to review the status of research on the key technical issues involved in PFNA, and to develop a list of those areas where additional modeling and/or experimentation were needed. The workshop also focused on development of a near-term experimental assessment program using existing prototypes and on development of a long-term test program at the Tacoma Testbed, where a PFNA prototype will be installed in 1995. A summary of conclusions reached at this workshop is presented. Results from analytic and Monte Carlo modeling of simplified PFNA systems are also presented.

Micklich, Bradley J.; Fink, Charles L.; Yule, Thomas J.




EPA Science Inventory

This report contains citations of publications for the years 1979-1982 on research conducted or supported by the Environmental Research Laboratory-Duluth. All published material has been organized into two major categories: (1) Journal Articles, Book Chapters, Proceedings, etc., ...


Researchers Find that Tumor Stem Cells are Good Models for Brain Tumor Research

Researchers have found that tumor stem cell lines derived directly from human glioblastoma brain tumors are a better model to study the biology and physiology of glioblastomas than are cancer cell lines that have been commonly used in cancer research laboratories.


Do Disadvantaged Students Get Less Effective Teaching? Key Findings from Recent Institute of Education Sciences Studies. NCEE Evaluation Brief. NCEE 2014-4010  

ERIC Educational Resources Information Center

Lack of researcher consensus on how to measure disadvantaged students' access to effective teaching has made it challenging for practitioners to draw lessons from the data. This brief aims to help policymakers understand the emerging evidence by synthesizing findings from three peer-reviewed studies that collectively span 17 states. The…

Max, Jeffrey; Glazerman, Steven



[Research progress on standards of commodity classes of Chinese materia medica and discussion on several key problems].  


Standards of commodity classes of Chinese materia medica is an important way to solve the "Lemons Problem" of traditional Chinese medicine market. Standards of commodity classes are also helpful to rebuild market mechanisms for "high price for good quality". The previous edition of commodity classes standards of Chinese materia medica was made 30 years ago. It is no longer adapted to the market demand. This article researched progress on standards of commodity classes of Chinese materia medica. It considered that biological activity is a better choice than chemical constituents for standards of commodity classes of Chinese materia medica. It is also considered that the key point to set standards of commodity classes is finding the influencing factors between "good quality" and "bad quality". The article also discussed the range of commodity classes of Chinese materia medica, and how to coordinate standards of pharmacopoeia and commodity classes. According to different demands, diversiform standards can be used in commodity classes of Chinese materia medica, but efficacy is considered the most important index of commodity standard. Decoction pieces can be included in standards of commodity classes of Chinese materia medica. The authors also formulated the standards of commodity classes of Notoginseng Radix as an example, and hope this study can make a positive and promotion effect on traditional Chinese medicine market related research. PMID:25095394

Yang, Guang; Zeng, Yan; Guo, Lan-Ping; Huang, Lu-Qi; Jin, Yan; Zheng, Yu-Guang; Wang, Yong-Yan



Research and Teaching: An Investigation of the Evolution of High School and Undergraduate Student Researchers' Understanding of Key Science Ethics Concepts  

ERIC Educational Resources Information Center

High school and undergraduate research students were surveyed over the 10-week period of their summer research programs to investigate their understanding of key concepts in science ethics and whether their understanding changed over the course of their summer research experiences. Most of the students appeared to understand the issues relevant to…

Mabrouk, Patricia Ann



Research education: findings of a study of teaching-learning research using multiple analytical perspectives.  


This multimethod, qualitative study provides results for educators of nursing doctoral students to consider. Combining the expertise of an empirical analytical researcher (who uses statistical methods) and an interpretive phenomenological researcher (who uses hermeneutic methods), a course was designed that would place doctoral students in the midst of multiparadigmatic discussions while learning fundamental research methods. Field notes and iterative analytical discussions led to patterns and themes that highlight the value of this innovative pedagogical application. Using content analysis and interpretive phenomenological approaches, together with one of the students, data were analyzed from field notes recorded in real time over the period the course was offered. This article describes the course and the study analysis, and offers the pedagogical experience as transformative. A link to a sample syllabus is included in the article. The results encourage nurse educators of doctoral nursing students to focus educational practice on multiple methodological perspectives. [J Nurs Educ. 2014;53(12):673-677.]. PMID:25406843

Vandermause, Roxanne; Barbosa-Leiker, Celestina; Fritz, Roschelle



Assessing the Key Processes of Youth-Led Participatory Research: Psychometric Analysis and Application of an Observational Rating Scale  

ERIC Educational Resources Information Center

Youth-led Participatory Action Research (YPAR)--in which young people conduct research aimed at improving problems in their schools and communities--is increasing in public health, youth development, and education. We report on the development and psychometric testing of the YPAR Process Template (YPT)--to assess the quality of key YPAR processes…

Ozer, Emily J.; Douglas, Laura



Clique-Finding for Heterogeneity and Multidimensionality in Biomarker Epidemiology Research: The CHAMBER Algorithm  

Microsoft Academic Search

Background: Commonly-occurring disease etiology may involve complex combinations of genes and exposures resulting in etiologic heterogeneity. We present a computational algorithm that employs clique-finding for heterogeneity and multidimensionality in biomedical and epidemiological research (the ''CHAMBER'' algorithm). Methodology\\/Principal Findings: This algorithm uses graph-building to (1) identify genetic variants that influence disease risk and (2) predict individuals at risk for disease based

Richard A. Mushlin; Stephen Gallagher; Aaron Kershenbaum; Timothy R. Rebbeck



Research on Key Project Improvement Management in Production Operation Management of Private Enterprise  

Microsoft Academic Search

The key project improvement management, as the main tool approach for continuous improvement of enterprises' system variability, helps the enterprise enhance performance management and guarantees the company's products to obtain sustainable competitive advantage. Through the analysis on the problems in the key project improvement management implemented by private enterprises, this paper advances some suggestions on the key project improvement management

Xia Wang; Yuhong Li; Jingjun Sun



Nutrition and Growth: Recent Research Findings and Research Priorities. Matrix No. 3.  

ERIC Educational Resources Information Center

Recent research indicates that low income adults and infants in the United States are more likely to be overweight than undernourished. Very possibly, the assumptions upon which food supplement programs are based are ill-founded. While many of the currently operating broadly conceived supplemental food programs achieve desirable collateral…

Graham, George G.


Translating research findings to promote peace: moving from "field to forum" with verbatim theatre.  


Peace, both personal and global, resides in understanding. Verbatim theatre is introduced as a vehicle for translating research findings to promote understanding and thereby, promote health. By shifting our translation lens from "bench to bedside" to "field to forum," new opportunities arise for moving nursing research-findings to an engaged audience. Stories from Pearl Harbor and Hiroshima survivors were woven into the verbatim performance, With Their Voices Raised. Analysis of audience members' reflections after the performance suggests that verbatim theatre created a connection based in openness, engagement, and trust that informed understanding and raised awareness about peace processes. PMID:23907299

Liehr, Patricia; Morris, Kate; Leavitt, Mary Ann; Takahashi, Ryutaro



Disclosure of incidental findings in cancer genomic research: investigators' perceptions on obligations and barriers.  


Although there has been significant research surrounding incidental findings (IFs), the guidelines and information provided to investigators remain unspecific, unclear, and often generalize the course of action to everyone in the field. We explored the perceptions and experiences of investigators regarding the return of IFs in genetic research. Researchers and clinician-researchers were invited to participate in semi-structured telephone interviews in Quebec and Ontario. Twenty professionals participated, and thematic analysis was used to analyze the transcriptions. Four contextual elements emerged: (i) degree of significance of results, (ii) respect for persons, (iii) infrastructure implications, and (iv) professional responsibilities. Our findings demonstrate that all investigators raised similar contextual elements surrounding the return of IFs. However, some nuances in participants' experiences of the understanding of professional responsibilities also emerged. Because of the existing nuances, a one-size-fits-all approach is inappropriate, suggesting that context ought to be considered in decisions about IFs. PMID:25492269

Kleiderman, E; Avard, D; Besso, A; Ali-Khan, S; Sauvageau, G; Hébert, J



DIII-D research towards resolving key issues for ITER and steady-state tokamaks  

NASA Astrophysics Data System (ADS)

The DIII-D research program is addressing key ITER research needs and developing the physics basis for future steady-state tokamaks. Pellet pacing edge-localized mode (ELM) control in the ITER configuration reduces ELM energy loss in proportion to 1/fpellet by inducing ELMs at up to 12× the natural ELM rate. Complete suppression of ELMs with resonant magnetic perturbations has been extended to the q95 expected for ITER baseline scenario discharges, and long-duration ELM-free QH-mode discharges have been produced with ITER-relevant co-current neutral-beam injection (NBI) using external n = 3 coils to generate sufficient counter-Ip torque. ITER baseline discharges at ?N ˜ 2 and scaled NBI torque have been maintained in stationary conditions for more than four resistive times using electron cyclotron current drive (ECCD) for tearing mode suppression and disruption avoidance; active tracking with steerable launchers and feedback control catch these modes at small amplitude, reducing the ECCD power required to suppress them. Massive high-Z gas injection into disruption-induced 300-600 kA 20 MeV runaway electron (RE) beams yield dissipation rates ˜10× faster than expected from e-e collisions and demonstrate the possibility of benign dissipation of such REs should they occur in ITER. Other ITER-related experiments show measured intrinsic plasma torque in good agreement with a physics-based model over a wide range of conditions, while first-time main-ion rotation measurements show it to be lower than expected from neoclassical theory. Core turbulence measurements show increased temperature fluctuations correlated with sharply enhanced electron transport when \

Hill, D. N.; the DIII-D Team



Key Topics for High-Lift Research: A Joint Wind Tunnel/Flight Test Approach  

NASA Technical Reports Server (NTRS)

Future high-lift systems must achieve improved aerodynamic performance with simpler designs that involve fewer elements and reduced maintenance costs. To expeditiously achieve this, reliable CFD design tools are required. The development of useful CFD-based design tools for high lift systems requires increased attention to unresolved flow physics issues. The complex flow field over any multi-element airfoil may be broken down into certain generic component flows which are termed high-lift building block flows. In this report a broad spectrum of key flow field physics issues relevant to the design of improved high lift systems are considered. It is demonstrated that in-flight experiments utilizing the NASA Dryden Flight Test Fixture (which is essentially an instrumented ventral fin) carried on an F-15B support aircraft can provide a novel and cost effective method by which both Reynolds and Mach number effects associated with specific high lift building block flows can be investigated. These in-flight high lift building block flow experiments are most effective when performed in conjunction with coordinated ground based wind tunnel experiments in low speed facilities. For illustrative purposes three specific examples of in-flight high lift building block flow experiments capable of yielding a high payoff are described. The report concludes with a description of a joint wind tunnel/flight test approach to high lift aerodynamics research.

Fisher, David; Thomas, Flint O.; Nelson, Robert C.



Organising health research systems as a key to improving health: the World Health Report 2013 and how to make further progress.  


The World Health Report 2013 provides a major boost to the health research community and, in particular, to those who believe that health research will make its greatest impact on improving health when it is organised through a systems approach. The World Health Report 2013, Research for Universal Health Coverage, starts with three key messages. Firstly, that universal health coverage, with full access to high-quality services, needs research evidence if it is to be achieved; second, all nations should conduct and use research; and finally, the report states that systems are needed to develop national research agendas, to raise funds, to strengthen research capacity, and to make effective use of research findings. Each of these themes is elaborated in the report and supported by extensive references.In this editorial, we first outline the key messages from the World Health Report 2013 and highlight the contributions made by papers from our journal, Health Research Policy and Systems. In addition, we discuss very recent papers that advance some issues even further. In particular, we consider new evidence both on how to achieve financial protection for those who use health services, and on whether healthcare professionals and organisations who engage in research provide an improved healthcare performance. Finally, we propose additional perspectives that add to the impressive body of evidence and analyses presented in the report. Specifically, we suggest that considering the needs of various stakeholders, as attempted in the UK, in parallel with analysing how to fulfil essential functions, should boost the prospects of successfully building and strengthening health research systems. This is important because research is vital for achieving universal health coverage, and consequently for improving the health of millions of people. PMID:24341347

Hanney, Stephen R; González-Block, Miguel A



New Findings and Future Directions for Subjective Well-Being Research  

ERIC Educational Resources Information Center

Recent findings on subjective well-being (SWB) are presented, and I describe the important questions for future research that these raise. Worldwide predictors of SWB such as social support and fulfillment of basic needs have been uncovered, and there are large differences in SWB between societies. A number of culture-specific predictors of SWB…

Diener, Ed



How Do Psychology Researchers Find Studies to Include in Meta-Analyses?  

ERIC Educational Resources Information Center

Meta-analysis is a technique used in a variety of disciplines to combine and summarize the findings of previous research. One step in the production of a meta-analysis is a thorough literature search for relevant studies. A variety of methods can be used to increase the number of studies that are found. This study examines the extent to which some…

Arendt, Julie



Public Understanding of Cognitive Neuroscience Research Findings: Trying to Peer beyond Enchanted Glass  

ERIC Educational Resources Information Center

This article considers the appeal of cognitive neuroscience research to the general public within the context of the deep puzzles involved in using our minds to understand how our minds work. It offers a few promising examples of findings that illuminate the ways of the mind and reveal these workings to be counter-intuitive with our subjective…

Grotzer, Tina A.



Undersea researchers find little oil spill damage so far By KRISTA KLAUS | News Channel 8  

E-print Network

Undersea researchers find little oil spill damage so far By KRISTA KLAUS | News Channel 8 Published of the Gulf of Mexico in the wake of BP's massive Deepwater Horizon oil spill made a brief stopover today life before and after the largest oil spill in the history of the Gulf of Mexico. #12;"This

Belogay, Eugene A.


A Simple Syllogism-Solving Test: Empirical Findings and Implications for "g" Research  

ERIC Educational Resources Information Center

It has been reported that the ability to solve syllogisms is highly "g"-loaded. In the present study, using a self-administered shortened version of a syllogism-solving test, the "BAROCO Short," we examined whether robust findings generated by previous research regarding IQ scores were also applicable to "BAROCO Short" scores. Five…

Shikishima, Chizuru; Yamagata, Shinji; Hiraishi, Kai; Sugimoto, Yutaro; Murayama, Kou; Ando, Juko



Kimmel Cancer Center researchers find biomarker links clinical outcome with new model of lethal tumor metabolism

Researchers at the Kimmel Cancer Center at Jefferson have demonstrated for the first time that the metabolic biomarker MCT4 directly links clinical outcomes with a new model of tumor metabolism that has patients “feeding” their cancer cells. Their findings were published online March 15 in Cell Cycle.


Finding links to cancer Masonic Cancer Center researchers work to identify carcinogens  

E-print Network

Finding links to cancer Masonic Cancer Center researchers work to identify carcinogens in the world around us--as well as ways to avoid them When scientists talk about "environmental" causes of cancer are linked to as many as two out of every three cancers diagnosed. DeAnn Lazovich, Ph.D., M.P.H., is one

Minnesota, University of


Researchers Find Abnormal Cells in the Blood Years before Leukemia is Diagnosed

Researchers have shown that abnormal white blood cells can be present in patients' blood more than six years prior to the diagnosis of a chronic form of lymphocytic leukemia. This finding may lead to a better understanding of the cellular changes that characterize the earliest stages of the disease and how it progresses.


Managing innovation and change processes: Findings from the Minnesota innovation research program  

Microsoft Academic Search

This article describes how innovations develop over time based on findings emerging from seven innovations included in the Minnesota Innovation Research Program. These observations are very different from typical models in the literature of the innovation process. The actual process is fluid, and includes an initial shock to propel the innovation into being, proliferation of the original idea, setbacks and

Roger Schroeder; Andrew Van de Ven; Gary Scudder; Douglas Polley



Can Research Findings Help School Systems Obtain the Most Bang from the Construction Bucks?  

ERIC Educational Resources Information Center

Research on educational facilities is important to help industry and school districts make decisions on funding and maintaining good educational environments for their students. This paper presents findings from three syntheses of 232 studies on educational facilities and funding decisions, followed by discussions of practical solutions designed…

Earthman, Glen I.; Lemasters, Linda K.


Anthropomorphic Agents as a User Interface Paradigm: Experimental Findings and a Framework for Research  

E-print Network

Anthropomorphic Agents as a User Interface Paradigm: Experimental Findings and a Framework on anthropomorphic agent interfaces has produced widely divergent results. We suggest that this is due-based interfaces. We propose a framework for studying anthropomorphic agents that can systematize the research

Stasko, John T.


Research-Doctorate Programs in the Biomedical Sciences: Selected Findings from the NRC Assessment  

ERIC Educational Resources Information Center

"Research Doctorate Programs in the Biomedical Sciences: Selected Findings from the NRC Assessment" examines data on the biomedical sciences programs to gather additional insight about the talent, training environment, outcomes, diversity, and international participation in the biomedical sciences workforce. This report supports an earlier…

Lorden, Joan F., Ed.; Kuh, Charlotte V., Ed.; Voytuk, James A., Ed.



[What happens to children and adolescents with mental disorders? Findings from long-term outcome research].  


Research on the long-term outcome of mental disorders originating in childhood and adolescence is an important part of developmental psychopathology. After a brief sketch of relevant terms of outcome research, the first part of this review reports findings based on heterotypic cohort studies. The major second part of this review presents findings based on long-term outcome studies dealing with homotypic diagnostic groups. In particular, the review focuses on the course and prognosis of ADHD, anxiety disorders, depression, conduct disorders, eating disorders, autism spectrum disorders, schizophrenia, and selective mutism. Findings mainly support the vulnerability hypothesis regarding mental disorders with early manifestation in childhood and adolescence as frequent precursors of mental disorders in adulthood. The discussion focuses on the impact of early manifesting disorders in the frame of general mental morbidity and of the effect of interventions, which is not yet sufficiently discernible. PMID:24240498

Steinhausen, Hans-Christoph



New research findings on emotionally focused therapy: introduction to special section.  


This article introduces the special section "New Research Findings on Emotionally Focused Therapy." Emotionally focused couple therapy researchers have a strong tradition of outcome and process research and this special section presents new findings from three recent studies. The first study furthers the goal of determining the kinds of clients for which EFT is effective (Denton, Wittenborn, & Golden, this issue) and the next two studies (Furrow, Edwards, Choi, & Bradley, this issue; Wittenborn, this issue) focus on the person of the therapist and provide some implications for EFT intervention and training. Together, these three studies provide valuable lessons on how to deepen our knowledge of the application of EFT for different populations and therapists. PMID:22765321

Johnson, Susan M; Wittenborn, Andrea K



Global Energy Technology Strategy: Addressing Climate Change Phase 2 Findings from an international Public-Private Sponsored Research Program  

SciTech Connect

This book examines the role of global energy technology in addressing climate change. The book considers the nature of the climate change challenge and the role of energy in the issue. It goes on to consider the implications for the evolution of the global energy system and the potential value of technology availability, development and deployment. Six technology systems are identified for special consideration: CO2 capture and storage, Biotechnology, Hydrogen systems, Nuclear energy, Wind and solar energy, and End-use energy technologies. In addition, consideration is given to the role of non-CO2 gases in climate change as well as the potential of technology development and deployment to reduce non-CO2 emissions. Present trends in energy R&D are examined and potentially fruitful avenues for research. The book concludes with a set of key findings.

Edmonds, James A.; Wise, Marshall A.; Dooley, James J.; Kim, Son H.; Smith, Steven J.; Runci, Paul J.; Clarke, Leon E.; Malone, Elizabeth L.; Stokes, Gerald M.



New findings and future directions for subjective well-being research.  


Recent findings on subjective well-being (SWB) are presented, and I describe the important questions for future research that these raise. Worldwide predictors of SWB such as social support and fulfillment of basic needs have been uncovered, and there are large differences in SWB between societies. A number of culture-specific predictors of SWB have also been found. Research on social comparison suggests that a world standard for a desirable income has developed. New findings on adaptation indicate that habituation to conditions is not always complete and that circumstances in some cases can have a large and lasting effect on SWB. An important finding is that high SWB benefits health, longevity, citizenship, and social relationships. Because of the benefits of SWB as well as the strong effects societal conditions can have on it, I proposed national accounts of SWB, which are now being seriously considered by nations. Finally, I review advances in methodology that are needed to move beyond conclusions based on simple cross-sectional correlations based on global self-report scales. Each of the findings raises new and important questions for future research. PMID:23163434

Diener, Ed



The crystalline revolution :ISO's finding opens a new research field, "astro-mineralogy"  

NASA Astrophysics Data System (ADS)

Silicate minerals were known to be a main component of dust in space, but detecting them in a crystallised state has been a surprise. It allows the identification of precise silicates in astronomical objects, which will open "a totally new field in astronomy: astro-mineralogy. This is the crystalline revolution", said the author, Dutch astronomer Rens Waters of Amsterdam university. "It's really fantastic, this possibility of identifying the silicates. Before ISO everybody thought that all silicates in space were amorphous, without a well-ordered internal structure; that means you cannot differentiate among the many different silicates existing. Now we can try to identify them and track their presence in different regions. A whole new research field is starting", said Rens Waters, who brought to the press conference samples of several terrestrial crystalline silicates: olivine and pyroxene, the most common silicates on Earth. Crystals give key clues about the physical conditions and evolutionary history of crystal-bearing objects. The precise mechanisms for crystal-making are now being researched now very actively in the laboratories, although some working-hypotheses are already being used. For instance, crystals can be made by heating the material to temperatures above 1 300 degrees Centigrade and then cooling it down slowly. Those found so far by ISO are at -170 degrees Centigrade, both in stellar envelopes and in protoplanetary discs. In the case of the old stars -red giant stars, where crystals are found to account for as much as 20% of all the surrounding dust, astronomers think that that the high temperatures near the star triggered the crystallisation of the silicates. In the protoplanetary discs some experts postulate that electric shocks - like lightning flashes - heated the dust, which cooled afterwards. "The crystals detected by ISO in these discs have a size of about a thousandth of a millimetre. They collide with each other, forming bigger and bigger bodies. Models predict that in about ten to one hundred million years they will make planets", Waters says. "In fact, crystalline silicates are very common in our own Solar System. You also have them in the comet Hale Bopp!". The reason why crystalline silicates had not been detected before in stars has to do with their low temperatures. Cold material emits mostly infrared light, which means an infrared space telescope like ESA's ISO was needed. The two high-resolution spectrometers on-board the satellite, able to detect the 'chemical fingerprint' of the crystals, did the rest. Astronomers are sure about the discovery because those chemical fingerprints, the spectra, can be compared in laboratories with spectra from crystalline silicates found on Earth. This method has demonstrated the crystalline structure and has even already allowed the identification of some of the crystals, such as forsterite and enstatite. However, crystalline silicates are a large family and their chemical signatures can be very similar; to enlarge the list of precise crystals more work will be needed, say experts in space chemistry. That is just one of the open questions requiring lab work. There's at least another one: crystalline silicates are found around old stars, in protoplanetary disks and in our own Solar System, but not in the space among the stars; astronomers can't explain it yet. "Crystalline silicates are synthesised around the stars; then that dust goes into the interstellar space, and enriches the raw material out of which more stars and planets will form. So you would expect crystals also to be in the interstellar medium! Crystals will certainly make us learn a lot...", says Waters. "This finding shows that ISO is really unveiling the chemistry of the Universe", says ESA astronomer Alberto Salama, chairman of the workshop about ISO results in spectroscopy held this week at ESA's Villafranca station in Madrid where the results were presented to the scientific community. "This is becoming more and more a 'hot



Mont Terri Underground Rock Laboratory, Switzerland-Research Program And Key Results  

NASA Astrophysics Data System (ADS)

Argillaceous formations generally act as aquitards because of their low hydraulic conductivities. This property, together with the large retention capacity of clays for cationic contaminants and the potential for self-sealing, has brought clay formations into focus as potential host rocks for the geological disposal of radioactive waste. Excavated in the Opalinus Clay formation, the Mont Terri underground rock laboratory in the Jura Mountains of NW Switzerland is an important international test site for researching clay formations. Research is carried out in the underground facility, which is located adjacent to the security gallery of the Mont Terri motorway tunnel. Fifteen partners from European countries, USA, Canada and Japan participate in the project. The objectives of the research program are to analyze the hydrogeological, geochemical and rock mechanical properties of the Opalinus Clay, to determine the changes induced by the excavation of galleries and by heating of the rock formation, to test sealing and container emplacement techniques and to evaluate and improve suitable investigation techniques. For the safety of deep geological disposal, it is of key importance to understand the processes occurring in the undisturbed argillaceous environment, as well as the processes in a disturbed system, during the operation of the repository. The objectives are related to: 1. Understanding processes and mechanisms in undisturbed clays and 2. Experiments related to repository-induced perturbations. Experiments of the first group are dedicated to: i) Improvement of drilling and excavation technologies and sampling methods; ii) Estimation of hydrogeological, rock mechanical and geochemical parameters of the undisturbed Opalinus Clay. Upscaling of parameters from laboratory to in situ scale; iii) Geochemistry of porewater and natural gases; evolution of porewater over time scales; iv) Assessment of long-term hydraulic transients associated with erosion and thermal scenarios and v) Evaluation of diffusion and retention parameters for long-lived radionuclides. Experiments related to repository-induced perturbations are focused on: i) Influence of rock liner on the disposal system and the buffering potential of the host rock; ii) Self-sealing processes in the excavation damaged zone; iii) Hydro-mechanical coupled processes (e.g. stress redistributions and pore pressure evolution during excavation); iv) Thermo-hydro-mechanical-chemical coupled processes (e.g. heating of bentonite and host rock) and v) Gas-induced transport of radionuclides in porewater and along interfaces in the engineered barrier system. A third research direction is to demonstrate the feasibility of repository construction and long-term safety after repository closure. Demonstration experiments can contribute to improving the reliability of the scientific basis for the safety assessment of future geological repositories, particularly if they are performed on a large scale and with a long duration. These experiments include the construction and installation of engineered barriers on a 1:1 scale: i) Horizontal emplacement of canisters; ii) Evaluation of the corrosion of container materials; repository re-saturation; iii) Sealing of boreholes and repository access tunnels and iv) Long-term monitoring of the repository. References Bossart, P. & Thury, M. (2008): Mont Terri Rock Laboratory. Project, Programme 1996 to 2007 and Results. - Rep. Swiss Geol. Surv. 3.

Nussbaum, C. O.; Bossart, P. J.



U-M researchers find driver of breast cancer stem cell metastasis

Researchers at the University of Michigan Comprehensive Cancer Center have found that a cancer gene linked to aggressive spread of the disease promotes breast cancer stem cells. The finding implies a new way to target the behavior of these lethal cells. The finding involves the cancer gene RhoC, which has previously been shown to promote metastasis of many types of cancer. RhoC levels increase as breast cancer progresses and high levels of RhoC are associated with worse patient survival.


Repackaging Prostate Cancer Support Group Research Findings: An e-KT Case Study.  


In the context of psychosocial oncology research, disseminating study findings to a range of knowledge "end-users" can advance the well-being of diverse patient subgroups and their families. This article details how findings drawn from a study of prostate cancer support groups were repackaged in a knowledge translation Web 2.0 features. Detailed are five lessons learned from developing the website: the importance of pitching a winning but feasible idea, keeping a focus on interactivity and minimizing text, negotiating with the supplier, building in formal pretests or a pilot test with end-users, and completing formative evaluations based on data collected through Google™ and YouTube™ Analytics. The details are shared to guide the e-knowledge translation efforts of other psychosocial oncology researchers and clinicians. PMID:24713522

Oliffe, John L; Han, Christina S; Lohan, Maria; Bottorff, Joan L



Research on the key technology and application of the packet transmission network  

NASA Astrophysics Data System (ADS)

In proportion to the rapid development of telecommunication service, Telecom Operators already have made a strategic transition from "Network, Communication Operators" into "integrated information service provider" to provide customer with varied information service, such as the BT "21st century plan", "Next" plan proposed by France Telecom, FNE and BMS plan by Australia Telstra, RANE Programs by NTT. Domestic Carries also made strategic transition plans. And the priority of network transition is to find the way to build a unified and integrated network supporting carrier-grade Ethernet service also compatible with the conventional network service. The division of the service results in the Packet transmission, namely packet technology, makes Packet-based Transmission Network keeping the virtues of transmission network. The virtues are good scalability, varied operation and maintenance, high-speed protection switching, connection-oriented feature, and building up connection with NMS. At the same time, it adds some characteristics to adapt the statistical multiplexing in the packet service, for instance: connection-oriented label switching, QoS mechanism, dynamic and flexible control plane. The Packet Transmission Network (PTN) can be divided into four layers: packet transmission channel layer (PTC), packet transmission path layer (PTP), and optional packet transmission section Layer (PTS) and physical layer. The key technologies of PTN are as follows: the connection-oriented based label transmission and the statistical multiplexing on packet switching. The use of layer and sub-domain is to provide good scalability. Supporting for fault detection and performance testing and other Operation, Management and Maintenance (OAM) function, linear protection switching, ring protection, dynamics survival technology of pre-placed re-route, QoS, circuit emulation for TDM service, ATM based on PWE3 technique, and MAC layer or physical layer based packet clock synchronization. The application PTN could be convergence of packet service in MAN, such ads DSLAM backhauling, wireless Backhauling and so on. PTN can also take replace the core router in the core network to carry out the high efficient transmission of packet service.

Yun, Xiang; Wang, Zhong



UNC researchers find new genetic target for a different kind of cancer drug

Researchers from the UNC School of Medicine have discovered that the protein RBM4, a molecule crucial to the process of gene splicing, is drastically decreased in multiple forms of human cancer, including lung and breast cancers. The finding, published in the journal Cancer Cell, offers a new route toward therapies that can thwart the altered genetic pathways that allow cancer cells to proliferate and spread.


Key Challenges for Tertiary Education Policy and Research--An Australian Perspective  

ERIC Educational Resources Information Center

Australia has had a mixed history in the way in which policy research has related to higher education policy. Recognising a history of policy-related research and to some extent research-informed policy-making, Australia has followed the trend of other New Public Management-driven systems of de-emphasising policy-oriented independent research. In…

Goedegebuure, Leo; Schoen, Marian



Language of instruction in Tanzania: Why are research findings not heeded?  

NASA Astrophysics Data System (ADS)

The issue of language of instruction (LOI) and its effects on education in Tanzanian secondary education has been widely researched since the early 1980s. In 2009, the Ministry of Education and Vocational Training proposed a new education and training policy that allows English to be used as LOI from nursery school to tertiary education. The proposed policy goes against what researchers in this area have recommended over the years. In the light of the proposed policy, the author of this article felt the need to review studies done on LOI in Tanzania from 1974 to date, aiming to eliminate or greatly reduce the negative effects of the policy on education in Tanzania. Quoting examples, the paper demonstrates students' levels of proficiency in English; suggests reasons why governmental policy has over time ignored research findings; and recommends as well as proposes the way forward.

Qorro, Martha A. S.



Identification and Characterization of Key Human Performance Issues and Research in the Next Generation Air Transportation System (NextGen)  

NASA Technical Reports Server (NTRS)

This report identifies key human-performance-related issues associated with Next Generation Air Transportation System (NextGen) research in the NASA NextGen-Airspace Project. Four Research Focus Areas (RFAs) in the NextGen-Airspace Project - namely Separation Assurance (SA), Airspace Super Density Operations (ASDO), Traffic Flow Management (TFM), and Dynamic Airspace Configuration (DAC) - were examined closely. In the course of the research, it was determined that the identified human performance issues needed to be analyzed in the context of NextGen operations rather than through basic human factors research. The main gaps in human factors research in NextGen were found in the need for accurate identification of key human-systems related issues within the context of specific NextGen concepts and better design of the operational requirements for those concepts. By focusing on human-system related issues for individual concepts, key human performance issues for the four RFAs were identified and described in this report. In addition, mixed equipage airspace with components of two RFAs were characterized to illustrate potential human performance issues that arise from the integration of multiple concepts.

Lee, Paul U.; Sheridan, Tom; Poage, james L.; Martin, Lynne Hazel; Jobe, Kimberly K.



Management of incidental findings during imaging research in “healthy” volunteers: current UK practice  

PubMed Central

Objectives Incidental findings (IF) are becoming increasingly common due to the proliferation of imaging research. IFs can be life-changing for “healthy” volunteers. This study examined variation in IF management in UK research studies of healthy volunteers, including comparison with ethical and legal guidelines, thus providing baseline data and informing future practice. Methods Questionnaire of participant background [medical/non-medical; radiologist/non-radiologist; years as principal investigator (PI)], type of research (involving children or not), institutional policy, volunteer information, radiologist involvement in reporting scans and IF disclosure mechanisms. Investigator's current and perceived “ideal” practice was examined. Participants were PIs performing imaging research of healthy volunteers approved by UK ethics committees (2006–2009). Results 63/146 (43%) surveys completed. 54/61 (88.5%) had site-specific guidelines. Information commonly provided to volunteers should IF be found: personal data (51/62; 82%), contingency plans (54/62; 87%) and disclosure to general practitioner (GP)/treating physician (47/62; 76%). PIs used different strategies for image review. Commonest: radiologist reports research scans only when researcher suspicious of IF [15/57 (26%) compared with 5/28 (16%) in ideal practice]. Commonest ideal reporting strategy: routine reporting by specialist radiologists [9/28 (29%) compared with 8/57 (14%) in current practice]. 49/56 (87.5%) have a standardised disclosure contingency plan, usually involving GP. PIs most commonly disclosed IFs to volunteers when judged relevant (27/58; 47%), most commonly face to face (22/54; 41%), by volunteer's GP (26/60; 43%). Background of PI influenced consent, reporting and disclosure practice. Conclusion There is wide variation in handling IFs in UK imaging research. Much of the current practice contravenes the vague existing legal and ethical guidelines, and is unlikely to be in the best interests of volunteers or researchers. PMID:21937616

Booth, T C; Waldman, A D; Wardlaw, J M; Taylor, S A; Jackson, A



Identifying tier one key suppliers.  


In today's global marketplace, businesses are becoming increasingly reliant on suppliers for the provision of key processes, activities, products and services in support of their strategic business goals. The result is that now, more than ever, the failure of a key supplier has potential to damage reputation, productivity, compliance and financial performance seriously. Yet despite this, there is no recognised standard or guidance for identifying a tier one key supplier base and, up to now, there has been little or no research on how to do so effectively. This paper outlines the key findings of a BCI-sponsored research project to investigate good practice in identifying tier one key suppliers, and suggests a scalable framework process model and risk matrix tool to help businesses effectively identify their tier one key supplier base. PMID:23615061

Wicks, Steve



Findings of the US research needs workshop on the topic of fusion power  

SciTech Connect

The US Department of Energy, Of?ce of Fusion Energy Sciences (OFES) conducted a Research Needs Workshop, referred to as ReNeW, in June 2009. The information developed at this workshop will help OFES develop a plan for US fusion research during the ITER era, roughly the next two decades. The workshop was organized in ?ve Themes, one of which was Harnessing Fusion Power (or Fusion Power for short). The top level goal of the Fusion Power Theme was to identify the research needed to develop the knowledge to design and build, with high con?dence, robust and reliable systems that can convert fusion products to useful forms of energy in a reactor environment, including a self-suf?cient supply of tritium fuel. Each Theme was subsequently subdivided into Panels to address speci?c topics. The Fusion Power Panel topics were: Fusion Fuel Cycle; Power Extraction; Materials Science; Safety and Environment; and Reliability, Availability, Maintainability and Inspectability (RAMI). Here we present the key ?ndings of the Fusion Power Theme.

Meier, Wayne R.; Raffray, R.; Kurtz, Richard J.; Morley, Neil B.; Reiersen, Wayne T.; Sharpe, Phil; Willms, Scott



Turning Points in the Life Course: Current Findings and Future Directions in Drug Use Research  

PubMed Central

Turning point, a key concept in the developmental life course approach, is currently understudied in the field of substance abuse, but merits further research. A turning point often involves a particular event, experience, or awareness that results in changes in the direction of a pathway or persistent trajectory over the long-term. This article (1) provides an overview of the relevant literature on the concept of turning points from the life course and developmental criminology perspectives, (2) reviews literature on turning points in substance use, (3) discusses methodological considerations, and (4) suggests areas for future research on turning points in drug use. The influence of life course concepts related to drug use trajectories and turning points (including, for example, timing and sequencing of life events, individual characteristics, human agency, and social and historical context) offers a potentially fruitful area of investigation that may increase our understanding of why and how drug users stop and resume using over the long-term. Further research on turning points may be particularly valuable in unpacking the multifaceted and complex underlying mechanisms and factors involved in lasting changes in drug use. PMID:20298174

Teruya, Cheryl; Hser, Yih-Ing



"Race to Top" Said to Lack Key Science: Scant Evidence for Policies, Researchers Tell Ed. Dept.  

ERIC Educational Resources Information Center

In comments on the proposed federal guidelines for stimulus funds, some researchers say there's no evidence for the policies touted. Among education researchers, one complaint about the U.S. Department of Education under former President George W. Bush was that it relentlessly promoted "scientific research in education," while at the same time…

Viadero, Debra



Childhood leukaemia risks: from unexplained findings near nuclear installations to recommendations for future research.  


Recent findings related to childhood leukaemia incidence near nuclear installations have raised questions which can be answered neither by current knowledge on radiation risk nor by other established risk factors. In 2012, a workshop was organised on this topic with two objectives: (a) review of results and discussion of methodological limitations of studies near nuclear installations; (b) identification of directions for future research into the causes and pathogenesis of childhood leukaemia. The workshop gathered 42 participants from different disciplines, extending widely outside of the radiation protection field. Regarding the proximity of nuclear installations, the need for continuous surveillance of childhood leukaemia incidence was highlighted, including a better characterisation of the local population. The creation of collaborative working groups was recommended for consistency in methodologies and the possibility of combining data for future analyses. Regarding the causes of childhood leukaemia, major fields of research were discussed (environmental risk factors, genetics, infections, immunity, stem cells, experimental research). The need for multidisciplinary collaboration in developing research activities was underlined, including the prevalence of potential predisposition markers and investigating further the infectious aetiology hypothesis. Animal studies and genetic/epigenetic approaches appear of great interest. Routes for future research were pointed out. PMID:24938793

Laurier, D; Grosche, B; Auvinen, A; Clavel, J; Cobaleda, C; Dehos, A; Hornhardt, S; Jacob, S; Kaatsch, P; Kosti, O; Kuehni, C; Lightfoot, T; Spycher, B; Van Nieuwenhuyse, A; Wakeford, R; Ziegelberger, G



Visual context and abstract language A well-documented finding in psycholinguistic research is that visual context rapidly affects  

E-print Network

Visual context and abstract language A well-documented finding in psycholinguistic research. It is an attempt to bridge between evidence coming from psycholinguistic and embodied language research on the role

Moeller, Ralf


Involving Scientists in Outreach: Incentives, Barriers, and Recommendations from Research Findings  

NASA Astrophysics Data System (ADS)

Public agencies that fund scientific research are increasingly requiring that researchers invest some of their funding in education or outreach activities that have a "broader impact." Yet barriers exist that inhibit scientists' motivation to participate in K-12 outreach. We will share findings from a quantitative and qualitative study that examined the motivations, rewards, and obstacles for scientists who participate in outreach. We found that most researchers became interested in doing outreach out of a desire to contribute and an expectation of having fun and enjoying the experience. They typically gave outreach presentations away from work, acted as a resource for school teachers, or helped with teacher professional development. However, scientists viewed outreach as a form of volunteer work that was auxiliary to their other responsibilities. Thus, time constraints, a lack of information about outreach opportunities, and the lower value placed on outreach by departments constituted significant barriers to their participation. Scientists involved in outreach typically found their efforts to be rewarding, but occasionally factors left a negative impression, such as poor audience response, classroom management difficulties, organizational problems, or demonstrations not going as planned. Based upon our findings, we offer recommendations on how scientists' participation and experiences in K-12 outreach can be improved, including how to successfully recruit scientists, create a positive outreach experience, and increase institutional support for outreach work.

Melton, G.; Laursen, S.; Andrews, E.; Weaver, A.; Hanley, D.; Shamatha, J. H.



Key Technology Research on the Flexible Welding Line for Multi-model Automobile  

Microsoft Academic Search

The paper shows that establishing the flexible multi- model welding line (FMWL) is necessary, which is the key technology for the flexible production. In this paper, some measures for implementing the flexible welding line for multi- model automobile were proposed from several aspects, such as process planning, switching mechanism, the robot interactive simulation, and automatic integrated control. And the modular

Xianghong Yang



Research of key technologies in a Windows CE-based monitoring and control system  

Microsoft Academic Search

This paper describes a Windows CE-based intelligent system that integrates control and monitoring in one platform. The overall structure of the system is given and some techniques used inside the customization and transplantation of the Windows CE OS are introduced as well. These key techniques include development and transplantation of device drivers in Windows CE, the realization of preserving registry

Jianmin Duan; Fan Lin; Zhen Liu



Research on the key technology of shared modeling between digital substation and control centre  

Microsoft Academic Search

The current way of information transmission between digital substation and the control centre is traditional, which increases the amount of maintenance, and gains grid security risks, and many other defects. By comparing digital substation SCD model with control centre CIM model, this paper represents the key technology of primary equipment model mapping, measurement model mapping and SVG model import and

Zhanghai Dong; Chenai Lin; Huanghai Feng; Ding Ji



Research on key techniques of missile general design and virtual shooting range  

Microsoft Academic Search

Missile general design is an important and challenging step in missile development, in which visual simulation of shooting range is one of the key function modules. Combining with the development of a certain multi-purpose missile, we design and realize a visual simulation system for the virtual shooting range. First, the function and structure of the missile general design system is

Xiao'an Tang; Min Chen; Shi Lin Zhou



Research toward control of key pecan insect pests using biorational pesticides  

Technology Transfer Automated Retrieval System (TEKTRAN)

Key pecan insect pests include the pecan weevil, Curculio caryae, black pecan aphid, Melanocallis caryaefoliae, and stink bugs. Alternative control tactics are needed for management of these pests in organic and conventional systems. Our objective was to evaluate the efficacy of several alternativ...


A decade of research with dyslexic college students: A summary of findings.  


The major findings of several research projects that investigated dyslexic college students are summarized in this paper. Consistent findings of these investigations led to the following conclusions. 1) Developmental dyslexia is a syndrome made up of the following four symptoms: slow rate of reading, error-prone oral reading, poor written spelling, and grammatically incorrect writing; 2) all these symptoms could be traced to a poor mastery of the grapheme-phoneme relational rules; 3) developmental dyslexia can be found in subjects who appear to have adequate oral language skills; 4) ex-dyslexics who appear to be "poor spellers but good readers" have subtle reading deficits; and 5) the 20 dyslexic subjects investigated appear to constitute a homogeneous group which raises questions regarding dyslexia subtypes. PMID:24243451

Aaron, P G; Phillips, S



Research on the Caretaking of Children of Incarcerated Parents: Findings and Their Service Delivery Implications  

PubMed Central

This paper reviews research findings on caretaking-related problems associated with the absence of parents from the home following incarceration. It focuses on the impact of incarceration on the welfare and adjustment of urban African American children and on the assumption of caretaking responsibilities by other caretakers, principally maternal grandmothers. Noting the complex situational difficulties involved and the potential burdens associated with surrogate parenting in general, and with this population in particular, the service-provider implications of this parenting arrangement are considered in this review. Findings indicate that problems associated with incarceration of parents tend to be intergenerational and vary considerably in complexity and severity. To the extent that they impact the children involved, these issues should be addressed in coordinated service delivery focusing on prevention. PMID:18311320

Hanlon, Thomas E.; Carswell, Steven B.; Rose, Marc



Dana-Farber researchers find new culprit in castration-resistant prostate cancer

Scientists at Dana-Farber Cancer Institute have discovered a molecular switch that enables advanced prostate cancers to spread without stimulation by male hormones, which normally are needed to spur the cancer's growth. They say the finding could lead to a new treatment for prostate cancers that are no longer controlled by hormone-blocking drugs. The researchers report in the Dec. 14 issue of Science that the molecular switch occurs in a protein, EZH2, which is increased in these tumors, termed castration-resistant prostate cancers (CRPC).


Virtualization of Research Universities: Raising the Right Questions to Address Key Functions of the Institution. Research & Occasional Paper Series. CSHE.6.03  

ERIC Educational Resources Information Center

The aim of this paper is to provide an overview of the variety of information and communication technology (ICT) applications at traditional universities and to integrate them into a holistic picture of the institution. Using the distinction of three key elements of scholarly activity (research, publication, education), it suggests a functional…

Pfeffer, Thomas



Psychosocial and pharmacological treatment of eating disorders: a review of research findings.  


Research on the treatment of eating disorders has focused primarily on cognitive-behavioral therapy (CBT) and, more recently, interpersonal psychotherapy (IPT). Numerous studies have shown that CBT is helpful in reducing symptoms of bulimia nervosa and binge-eating disorder. In addition, CBT has been found to be superior or comparable to other psychotherapies in reducing bulimic symptoms. Preliminary findings indicate that CBT and IPT produce similar results at follow-up for bulimia nervosa and binge-eating disorder. Antidepressant medications are also useful in the treatment of bulimia nervosa and binge-eating disorder, but are less likely to result in remission of symptoms than CBT. The results from comparison studies are inconsistent, with modest evidence that combining antidepressant medication and psychotherapy produces greater improvement in bulimic symptoms. Limited research has been conducted on the treatment of anorexia nervosa, although preliminary studies suggest that psychotherapy and fluoxetine may be helpful in preventing relapse after weight restoration. PMID:10445860

Peterson, C B; Mitchell, J E



Is it worth engaging in multi-stakeholder health services research collaborations? Reflections on key benefits, challenges and enabling mechanisms.  


Multi-Stakeholder Health Services Research Collaborations (M-SHSRCs) are increasingly pursued internationally to undertake complex implementation research that aims to directly improve the organisation and delivery of health care. Yet the empirical evidence supporting M-SHSRCs' capacity to achieve such goals is limited, and significant impediments to effective implementation are identified in the literature. This dichotomy raises the question, 'is it worth engaging in M-SHSRCs?' In this paper, we contribute to the narrative evidence-base by outlining key issues emerging from our substantial collaborative experience in Australia. Key benefits, challenges and mechanisms that may enable effective implementation of M-SHSRCs in other contexts are highlighted. We conclude that M-SHSRCs are worthwhile and succeed through significant financial, temporal and emotional investments. PMID:24519121

Hinchcliff, Reece; Greenfield, David; Braithwaite, Jeffrey



Identifying key patient demographics and organizational factors that contribute to health center participation in research.  


Federally Qualified Health Centers are well positioned for translational research given their diverse patient population, unique characteristics, and community knowledge. This was the first national survey that assessed their research activities. Those with research experience were more likely to be urban and Health Care for the Homeless grantees and had more patients, minority patients, and physicians relative to nonphysician providers, enabling services providers, Medicaid revenues per Medicaid patient, and total revenues per patient than health centers with no experience and no future interest in research. Only enabling services providers to patient ratios and total patients remained significant after controlling for other factors. PMID:24887526

Shin, Peter; Sharac, Jessica; Beeson, Tishra; Proser, Michelle; Jester, Michelle



Science in the Eyes of Preschool Children: Findings from an Innovative Research Tool  

NASA Astrophysics Data System (ADS)

How do young children view science? Do these views reflect cultural stereotypes? When do these views develop? These fundamental questions in the field of science education have rarely been studied with the population of preschool children. One main reason is the lack of an appropriate research instrument that addresses preschool children's developmental competencies. Extensive body of research has pointed at the significance of early childhood experiences in developing positive attitudes and interests toward learning in general and the learning of science in particular. Theoretical and empirical research suggests that stereotypical views of science may be replaced by authentic views following inquiry science experience. However, no preschool science intervention program could be designed without a reliable instrument that provides baseline information about preschool children's current views of science. The current study presents preschool children's views of science as gathered from a pioneering research tool. This tool, in the form of a computer "game," does not require reading, writing, or expressive language skills and is operated by the children. The program engages children in several simple tasks involving picture recognition and yes/no answers in order to reveal their views about science. The study was conducted with 120 preschool children in two phases and found that by the age of 4 years, participants possess an emergent concept of science. Gender and school differences were detected. Findings from this interdisciplinary study will contribute to the fields of early childhood, science education, learning technologies, program evaluation, and early childhood curriculum development.

Dubosarsky, Mia D.


Subsonic Transonic Applied Refinements By Using Key Strategies - STARBUKS In the NASA Langley Research Center National Transonic Facility  

NASA Technical Reports Server (NTRS)

Several upgrade projects have been completed at the NASA Langley Research Center National Transonic Facility over the last 1.5 years in an effort defined as STARBUKS - Subsonic Transonic Applied Refinements By Using Key Strategies. This multi-year effort was undertaken to improve NTF's overall capabilities by addressing Accuracy and Validation, Productivity, and Reliability areas at the NTF. This presentation will give a brief synopsis of each of these efforts.

Paryz, Roman W.



Joint Venture Manufacturing in China-Key Opportunities for Operations Management Research  

Microsoft Academic Search

ABSTRACT International joint venture,manufacturing,is important,for both,the Chinese economy and the large number,of foreign companies,which,are investing,in China. A literature survey,investigated,previous,research,in this area from,both,Western,and,Chinese researchers,(and published,in either English or Chinese). By reviewing,the extant

Zhang Lihong; Keith Goffin


The use of marketing research and intelligence in strategic planning: key issues and future trends  

Microsoft Academic Search

Many large companies in Asia are turning to market intelligence for input into their strategic management system and decision making. Conventional marketing research is increasingly viewed as being too narrowly focused on tactical and operational issues. It is characterized by an overriding concern with data rather than analysed information and the research is often conducted in response to an apparent

Thomas Tan Tsu Wee



Key Challenges and New Trends in Battery Research (2011 EFRC Forum)  

SciTech Connect

Jean-Marie Tarascon, Professor at the University de Picardie Jules Verne, France, was the fourth speaker in the May 26, 2011 EFRC Forum session, "Global Perspectives on Frontiers in Energy Research." In his presentation, Professor Tarascon recounted European basic research activates in electrical energy storage. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss "Science for our Nation's Energy Future." In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several “grand challenges” and use-inspired “basic research needs” recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

Tarascon, Jean Marie (University de Picardie Jules Verne, France) [University de Picardie Jules Verne, France



Contextualizing CBPR: Key Principles of CBPR meet the Indigenous research context  

PubMed Central

This paper addresses two questions regarding the use of Community-based Participatory Research (CBPR) approaches with tribal communities. First, how do “gold standard” CBPR principles hold up when applied to Native American communities and what additional contextual information is necessary to understand and work with these principles in this setting? Second, what additional principles or recommendations are helpful for researchers interested in conducting research using a CBPR approach with tribal communities? We studied a variety of literature sources on CBPR and Native health research to answer these questions. We are unaware of any publications that contextualize CBPR principles for working with specific populations. This information has direct application for conducting research with tribal communities, and confirms the importance of using CBPR approaches in this setting. PMID:20150951

LaVeaux, Deborah; Christopher, Suzanne



Application of research findings and summary of research needs: Bud Britton Memorial Symposium on Metabolic Disorders of Feedlot Cattle.  


Updated research findings with acidosis, feedlot bloat, liver abscesses, and sudden death syndromes were presented at the Bud Britton Memorial Symposium on Metabolic Disorders of Feedlot Cattle. Possible industry applications include the need to establish guidelines for use of clostridial vaccines in feedlot cattle, further assessment of the relationship between acidosis and polioencephalomalacia, examination of the effects of various ionophores on the incidence of metabolic disorders, and evaluation of the effects of feed bunk management and limit- and restricted-feeding programs on the incidence of metabolic disorders. A multidisciplinary approach among researchers, consulting nutritionists and veterinarians, and feedlot managers will be required for effective progress in research and in the application of research findings. Areas suggested for further research include 1) assessment of feed consumption patterns and social behavior of cattle in large-pen, feedlot settings; 2) evaluation of the relationship between feed intake management systems (feed bunk management programs, limit- and programmed-feeding) and the incidence of metabolic disorders, including delineation of the role of variability in feed intake in the etiology of such disorders; 3) efforts to improve antemortem and postmortem diagnosis, and to establish standardized regional or national epidemiological databases for various metabolic disorders; 4) ascertaining the accuracy of diagnosis of metabolic disorders and determining the relationship of previous health history of animals to the incidence of metabolic disorders; 5) further defining ruminal and intestinal microbiology as it relates to metabolic disorders and deeper evaluation of metabolic changes that occur with such disorders; 6) continued appraisal of the effects of grain processing and specific feed ingredients and nutrients on metabolic disorders, and development of new feed additives to control or prevent these disorders; and 7) application of biotechnology to develop grain varieties with altered nutrient degradation profiles that decrease the propensity for disastrous acid loads in the rumen, feed-grade enzymes and probiotics that modify nutrient digestion or microbial profiles in the rumen and intestine, and specific strains of ruminal bacteria and protozoa that alter ruminal and metabolic conditions that may precipitate metabolic disorders. PMID:9464915

Galyean, M L; Eng, K S



Improving Instruction for Students with Learning Disabilities: The Results of Three Research Syntheses. Keys to Successful Learning: A National Summit on Research in Learning Disabilities.  

ERIC Educational Resources Information Center

This booklet presents three brief papers that summarize three meta-analytic research syntheses of instruction for students with learning disabilities. The first paper is "Intervention Research for Students with Learning Disabilities" by H. Lee Swanson. Findings that resulted from a review of 272 studies are grouped into those on most effective…

National Center for Learning Disabilities, Inc., New York, NY.


Exome Sequencing and Unrelated Findings in the Context of Complex Disease Research: Ethical and Clinical Implications  

PubMed Central

Exome sequencing has identified the causes of several Mendelian diseases, although it has rarely been used in a clinical setting to diagnose the genetic cause of an idiopathic disorder in a single patient. We performed exome sequencing on a pedigree with several members affected with attention deficit/hyperactivity disorder (ADHD), in an effort to identify candidate variants predisposing to this complex disease. While we did identify some rare variants that might predispose to ADHD, we have not yet proven the causality for any of them. However, over the course of the study, one subject was discovered to have idiopathic hemolytic anemia (IHA), which was suspected to be genetic in origin. Analysis of this subject’s exome readily identified two rare non-synonymous mutations in PKLR gene as the most likely cause of the IHA, although these two mutations had not been documented before in a single individual. We further confirmed the deficiency by functional biochemical testing, consistent with a diagnosis of red blood cell pyruvate kinase deficiency. Our study implies that exome and genome sequencing will certainly reveal additional rare variation causative for even well-studied classical Mendelian diseases, while also revealing variants that might play a role in complex diseases. Furthermore, our study has clinical and ethical implications for exome and genome sequencing in a research setting; how to handle unrelated findings of clinical significance, in the context of originally planned complex disease research, remains a largely uncharted area for clinicians and researchers. PMID:21794208

Lyon, Gholson J.; Jiang, Tao; Van Wijk, Richard; Wang, Wei; Bodily, Paul Mark; Xing, Jinchuan; Tian, Lifeng; Robison, Reid J.; Clement, Mark; Lin, Yang; Zhang, Peng; Liu, Ying; Moore, Barry; Glessner, Joseph T.; Elia, Josephine; Reimherr, Fred; van Solinge, Wouter W.; Yandell, Mark; Hakonarson, Hakon; Wang, Jun; Johnson, William Evan; Wei, Zhi; Wang, Kai



UNC researchers engineer 'protein switch' to dissect role of cancer’s key players

Researchers at the University of North Carolina at Chapel Hill School of Medicine have “rationally rewired” some of the cell’s smallest components to create proteins that can be switched on or off by command. These “protein switches” can be used to interrogate the inner workings of each cell, helping scientists uncover the molecular mechanisms of human health and disease. In the first application of this approach, the UNC researchers showed how a protein called Src kinase influences the way cells extend and move, a previously unknown role that is consistent with the protein’s ties to tumor progression and metastasis. UNC is home to the Lineberger Comprehensive Cancer Center.


[Psychotherapy of alcohol addiction--principles and new findings of therapy research].  


The psychotherapy of alcohol dependence has for long been neglected by psychiatric research. Meanwhile a number of clinical and experimental studies have been performed to examine the efficacy of different kinds of psychotherapeutic approaches in alcoholism. Most clinical settings follow an integrative concept based on behavioural and coping skills therapy, psychodynamic or psychoanalytic and family therapy. Further therapy elements are self-help groups or muscular relaxation, among others. Most therapies are conducted as group therapy but individual therapy is a well-examined alternative. Early intervention in alcohol dependence is of special relevance. Motivational enhancement is a key goal of alcohol therapy and can already be implemented in early interventions or in the detoxification phase. Results of clinical studies suggest that after inpatient treatment 30-40% of patients remain abstinent. Outpatient treatment of alcoholism has for long been neglected, with only few prospective studies conducted so far. The most ambitious study has been the US Project Match. A difficult question remains the allocation of patients to different treatments. Current concepts of treatment for alcoholics are described and results of different treatment studies are given. PMID:11603209

Soyka, M; Helten, C; Scharfenberg, C O



Informationist programme in support of biomedical research: a programme description and preliminary findings of an evaluation  

PubMed Central

Background The informationist programme at the Library of the National Institutes of Health (NIH) in Bethesda, MD, USA has grown to 14 informationists working with 40 clinical and basic science research teams. Purpose This case report, intended to contribute to the literature on informationist programmes, describes the NIH informationist programme including implementation experiences, the informationists' training programme, their job responsibilities and programme outcomes. Brief description The NIH informationist programme was designed to enhance the library's service capacity. Over time, the steps for introducing the service to new groups were formalized to ensure support by leadership, the team being served and the library. Job responsibilities also evolved from traditional library roles to a wide range of knowledge management activities. The commitment by the informationist, the team and the library to continuous learning is critical to the programme's success. Results/outcomes NIH scientists reported that informationists saved them time and contributed to teamwork with expert searching and point-of-need instruction. Process evaluation helped refine the programme. Evaluation method High-level, preliminary outcomes were identified from a survey of scientists receiving informationist services, along with key informant interviews. Process evaluation examined service implementation, informationists' training, and service components. Anecdotal evidence has also indicated a favorable response to the programme. PMID:18494648

Whitmore, Susan C.; Grefsheim, Suzanne F.; Rankin, Jocelyn A.



Behavioral science in video games for children's diet and physical activity change: Key research needs  

Technology Transfer Automated Retrieval System (TEKTRAN)

Innovative intervention programs are needed to overcome the limitations in previous programs that promoted change in diabetes risk behaviors in children. Serious video games show promise of changing dietary and physical activity behaviors, but research is needed on the optimal design of behavior-cha...


Collaboration Is Key: Librarians and Composition Instructors Analyze Student Research and Writing  

ERIC Educational Resources Information Center

This study describes a collaborative research project between two composition instructors and two librarians that analyzed citation patterns among students in the First-year Composition Program at the University of Georgia. Built upon earlier bibliometric studies, this study seeks not only to examine a large data set of citations--larger than was…

Barratt, Caroline Cason; Nielsen, Kristin; Desmet, Christy; Balthazor, Ron



Near Field Communication Technology as the Key for Data Acquisition in Clinical Research  

Microsoft Academic Search

Electronic data capture systems are utilized to collect, document, and process research data for clinical trials. Ideally, the workflow of collecting the data could be simplified by using mobile clients that enable for data acquisition at the point-of-care. Mobile phones provide a range of features to act as data acquisition unit for clinical trials. A novel approach towards an automated

J. Morak; D. Hayn; P. Kastner; M. Drobics; G. Schreier



Current progress in network research: toward reference networks for key model organisms  

Microsoft Academic Search

The collection of multiple genome-scale datasets is now routine, and the frontier of research in systems biology has shifted accordingly. Rather than clustering a single dataset to produce a static map of functional modules, the focus today is on data integration, network alignment, interactive visualization and ontological markup. Because of the intrinsic noisiness of high-throughput measurements, statistical methods have been

Balaji S. Srinivasan; Nigam H. Shah; Jason Flannick; Eduardo Abeliuk; Antal F. Novak; Serafim Batzoglou



Signature Concepts of Key Researchers in North American Higher Education Teaching and Learning  

ERIC Educational Resources Information Center

Universities in the English-speaking world share a common ancestry that extends back to medieval times. From these beginnings universities quickly developed distinctive qualities as they became integrated within different social and cultural systems of their home societies. A number of comparisons of higher education research have shown major…

Kandlbinder, Peter



Understanding the No Child Left Behind Act of 2001: Scientifically Based Research. NCREL Quick Key 7  

ERIC Educational Resources Information Center

As a result of the No Child Left Behind (NCLB) Act of 2001, schools and districts are seeking information to identify, plan, and implement federally funded programs and practices that have been proven to be effective through scientifically based research (SBR). The purpose of this brochure is to help administrators, educators, parents, and…

Learning Point Associates / North Central Regional Educational Laboratory (NCREL), 2004



Rape Treatment Outcome Research: Empirical Findings and State of the Literature  

PubMed Central

This article reviews empirical support for treatments targeting women sexually assaulted during adolescence or adulthood. Thirty-two articles were located using data from 20 separate samples. Of the 20 samples, 12 targeted victims with chronic symptoms, three focused on the acute period post-assault, two included women with chronic and acute symptoms, and three were secondary prevention programs. The majority of studies focus on posttraumatic stress disorder (PTSD), depression, and/or anxiety as treatment targets. Cognitive Processing Therapy and Prolonged Exposure have garnered the most support with this population. Stress Inoculation Training and Eye Movement Desensitization and Reprocessing also show some efficacy. Of the four studies that compared active treatments, few differences were found. Overall, cognitive behavioral interventions lead to better PTSD outcomes than supportive counseling does. However, even in the strongest treatments more than one-third of women retain a PTSD diagnosis at post-treatment or drop out of treatment. Discussion highlights the paucity of research in this area, methodological limitations of examined studies, generalizability of findings, and important directions for future research at various stages of trauma recovery. PMID:19442425

Vickerman, Katrina A.; Margolin, Gayla



Healthy Universities: current activity and future directions--findings and reflections from a national-level qualitative research study.  


This qualitative study used questionnaires to scope and explore 'healthy universities' activity taking place within English higher education institutions (HEIs). The findings revealed a wealth of health-related activity and confirmed growing interest in the healthy universities approach--reflecting an increasing recognition that investment for health within the sector will contribute not only to health targets but also to mainstream agendas such as staff and student recruitment, experience and retention; and institutional and societal productivity and sustainability. However, they also suggested that, while there is growing understanding of the need for a comprehensive whole system approach to improving health within higher education settings, there are a number of very real challenges--including a lack of rigorous evaluation, the difficulty of integrating health into a 'non-health' sector and the complexity of securing sustainable cultural change. Noting that health and well-being remain largely marginal to the core mission and organization of higher education, the article goes on to reflect on the wider implications for future research and policy at national and international levels. Within England, whereas there are Healthy Schools and Healthy Further Education Programmes, there is as yet no government-endorsed programme for universities. Similarly, at an international level, there has been no systematic investment in higher education mirroring the comprehensive and multifaceted Health Promoting Schools Programme. Key issues highlighted are: securing funding for evaluative research within and across HEIs to enable the development of a more robust evidence base for the approach; advocating for an English National Healthy Higher Education Programme that can help to build consistency across the entire spectrum of education; and exploring with the World Health Organization (WHO) and the International Union for Health Promotion and Education (IUHPE) the feasibility of developing an international programme. PMID:21495435

Dooris, Mark; Doherty, Sharon



Key Technology Research on Open Architecture for The Sharing of Heterogeneous Geographic Analysis Models  

NASA Astrophysics Data System (ADS)

In recent years, the increasing development of cloud computing technologies laid critical foundation for efficiently solving complicated geographic issues. However, it is still difficult to realize the cooperative operation of massive heterogeneous geographical models. Traditional cloud architecture is apt to provide centralized solution to end users, while all the required resources are often offered by large enterprises or special agencies. Thus, it's a closed framework from the perspective of resource utilization. Solving comprehensive geographic issues requires integrating multifarious heterogeneous geographical models and data. In this case, an open computing platform is in need, with which the model owners can package and deploy their models into cloud conveniently, while model users can search, access and utilize those models with cloud facility. Based on this concept, the open cloud service strategies for the sharing of heterogeneous geographic analysis models is studied in this article. The key technology: unified cloud interface strategy, sharing platform based on cloud service, and computing platform based on cloud service are discussed in detail, and related experiments are conducted for further verification.

Yue, S. S.; Wen, Y. N.; Lv, G. N.; Hu, D.



Telethon Network of Genetic Biobanks: a key service for diagnosis and research on rare diseases  

PubMed Central

Several examples have always illustrated how access to large numbers of biospecimens and associated data plays a pivotal role in the identification of disease genes and the development of pharmaceuticals. Hence, allowing researchers to access to significant numbers of quality samples and data, genetic biobanks are a powerful tool in basic, translational and clinical research into rare diseases. Recently demand for well-annotated and properly-preserved specimens is growing at a high rate, and is expected to grow for years to come. The best effective solution to this issue is to enhance the potentialities of well-managed biobanks by building a network. Here we report a 5-year experience of the Telethon Network of Genetic Biobanks (TNGB), a non-profit association of Italian repositories created in 2008 to form a virtually unique catalogue of biospecimens and associated data, which presently lists more than 750 rare genetic defects. The process of TNGB harmonisation has been mainly achieved through the adoption of a unique, centrally coordinated, IT infrastructure, which has enabled (i) standardisation of all the TNGB procedures and activities; (ii) creation of an updated TNGB online catalogue, based on minimal data set and controlled terminologies; (iii) sample access policy managed via a shared request control panel at web portal. TNGB has been engaged in disseminating information on its services into both scientific/biomedical - national and international - contexts, as well as associations of patients and families. Indeed, during the last 5-years national and international scientists extensively used the TNGB with different purposes resulting in more than 250 scientific publications. In addition, since its inception the TNGB is an associated member of the Biobanking and Biomolecular Resources Research Infrastructure and recently joined the EuroBioBank network. Moreover, the involvement of patients and families, leading to the formalization of various agreements between TNGB and Patients’ Associations, has demonstrated how promoting Biobank services can be instrumental in gaining a critical mass of samples essential for research, as well as, raising awareness, trust and interest of the general public in Biobanks. This article focuses on some fundamental aspects of networking and demonstrates how the translational research benefits from a sustained infrastructure. PMID:24004821



Network structure and the role of key players in a translational cancer research network: a study protocol  

PubMed Central

Introduction Translational research networks are a deliberate strategy to bridge the gulf between biomedical research and clinical practice through interdisciplinary collaboration, supportive funding and infrastructure. The social network approach examines how the structure of the network and players who hold important positions within it constrain or enable function. This information can be used to guide network management and optimise its operations. The aim of this study was to describe the structure of a translational cancer research network (TCRN) in Australia over its first year, identify the key players within the network and explore these players' opportunities and constraints in maximising important network collaborations. Methods and analysis This study deploys a mixed-method longitudinal design using social network analysis augmented by interviews and review of TCRN documents. The study will use network documents and interviews with governing body members to explore the broader context into which the network is embedded as well as the perceptions and expectations of members. Of particular interest are the attitudes and perceptions of clinicians compared with those of researchers. A co-authorship network will be constructed of TCRN members using journal and citation databases to assess the success of past pre-network collaborations. Two whole network social network surveys will be administered 12?months apart and parameters such as density, clustering, centrality and betweenness centrality computed and compared using UCINET and Netdraw. Key players will be identified and interviewed to understand the specific activities, barriers and enablers they face in that role. Ethics and dissemination Ethics approvals were obtained from the University of New South Wales, South Eastern Sydney Northern Sector Local Health Network and Calvary Health Care Sydney. Results will be discussed with members of the TCRN, submitted to relevant journals and presented as oral presentations to clinicians, researchers and policymakers. PMID:22734122

Cunningham, Frances C; Braithwaite, Jeffrey



Informed consent for living donation: a review of key empirical studies, ethical challenges and future research.  


Given the organ scarcity, live organ donation is increasingly considered a viable alternative for kidney and liver transplantation. Yet living donation challenges the ethical principle of nonmaleficence by subjecting healthy individuals to medical, psychosocial and unknown risks. Therefore, transplant providers, policy-makers and donors are committed to ensuring that prospective donors provide adequate informed consent to undergo the procedure. Informed consent for living donation is ethically required as a means of demonstrating respect for donor's autonomy and protecting their safety. However, all elements of informed consent are fraught with difficulties due to the unique nature of the donation process and outcome. This paper reviews empirical research on informed consent for live kidney donors (LKD) and live liver donors (LLD) for both adult and pediatric recipients. As this review shows, studies that empirically assessed the quality of informed consent elements reveal considerable variability and deficiencies across the informed consent process, suggesting the need for improvement. This review highlights challenges to each element of consent for both LKDs and LLDs, and situates trends within broader policy contexts, ethical debates and avenues for future innovative research. PMID:22594620

Gordon, E J



Huntsman researchers find that reduced kidney function is associated with higher risk of renal and urothelial cancer

Researchers who investigated the level of kidney function and subsequent cancer risk in more than one million adults have found that reduced glomerular filtration rate is a key measure of reduced kidney function and chronic kidney disease is an independent risk factor for renal and urothelial cancer but not other cancer types.


UC Davis researchers find that a double-headed motor protein offers new targets in cancer treatment

The structure of a key part of the machinery that allows cells to divide has been identified by researchers at the University of California, Davis, opening new possibilities for throwing a wrench in the machine and blocking runaway cell division in cancer.


Can I be sued for that? Liability risk and the disclosure of clinically significant genetic research findings.  


Genomic researchers increasingly are faced with difficult decisions about whether, under what circumstances, and how to return research results and significant incidental findings to study participants. Many have argued that there is an ethical-maybe even a legal-obligation to disclose significant findings under some circumstances. At the international level, over the last decade there has begun to emerge a clear legal obligation to return significant findings discovered during the course of research. However, there is no explicit legal duty to disclose in the United States. This creates legal uncertainty that may lead to unmanaged variation in practice and poor quality care. This article discusses liability risks associated with the disclosure of significant research findings for investigators in the United States. PMID:24676095

McGuire, Amy L; Knoppers, Bartha Maria; Zawati, Ma'n H; Clayton, Ellen Wright



Research Interests: Outside of life (plants and animals) I find process plasmas to be the most complex and  

E-print Network

Research Interests: Outside of life (plants and animals) I find process plasmas to be the most neutralization of the ions and subsequent reflection of energetic neutrals into the gas phase. These fast

Goeckner, Matthew


St. Jude research finds that survivors of childhood cancer at risk for developing hormone deficiencies as adults

St. Jude Children’s Research Hospital finds childhood cancer patients treated with cranial irradiation may have hormone deficiencies that impact health decades later; results highlight need for lifelong health screenings.


St. Jude researchers find that unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors

St. Jude Children’s Research Hospital study finds that few adult survivors of childhood cancer follow a heart-healthy lifestyle that protects against heart disease, diabetes and other health problems.


Can I be sued for that? Liability risk and the disclosure of clinically significant genetic research findings  

PubMed Central

Genomic researchers increasingly are faced with difficult decisions about whether, under what circumstances, and how to return research results and significant incidental findings to study participants. Many have argued that there is an ethical—maybe even a legal—obligation to disclose significant findings under some circumstances. At the international level, over the last decade there has begun to emerge a clear legal obligation to return significant findings discovered during the course of research. However, there is no explicit legal duty to disclose in the United States. This creates legal uncertainty that may lead to unmanaged variation in practice and poor quality care. This article discusses liability risks associated with the disclosure of significant research findings for investigators in the United States. PMID:24676095

McGuire, Amy L.; Knoppers, Bartha Maria; Zawati, Ma’n H.; Clayton, Ellen Wright



Molecular locks and keys: the role of small molecules in phytohormone research  

PubMed Central

Plant adaptation, growth and development rely on the integration of many environmental and endogenous signals that collectively determine the overall plant phenotypic plasticity. Plant signaling molecules, also known as phytohormones, are fundamental to this process. These molecules act at low concentrations and regulate multiple aspects of plant fitness and development via complex signaling networks. By its nature, phytohormone research lies at the interface between chemistry and biology. Classically, the scientific community has always used synthetic phytohormones and analogs to study hormone functions and responses. However, recent advances in synthetic and combinational chemistry, have allowed a new field, plant chemical biology, to emerge and this has provided a powerful tool with which to study phytohormone function. Plant chemical biology is helping to address some of the most enduring questions in phytohormone research such as: Are there still undiscovered plant hormones? How can we identify novel signaling molecules? How can plants activate specific hormone responses in a tissue-specific manner? How can we modulate hormone responses in one developmental context without inducing detrimental effects on other processes? The chemical genomics approaches rely on the identification of small molecules modulating different biological processes and have recently identified active forms of plant hormones and molecules regulating many aspects of hormone synthesis, transport and response. We envision that the field of chemical genomics will continue to provide novel molecules able to elucidate specific aspects of hormone-mediated mechanisms. In addition, compounds blocking specific responses could uncover how complex biological responses are regulated. As we gain information about such compounds we can design small alterations to the chemical structure to further alter specificity, enhance affinity or modulate the activity of these compounds. PMID:25566283

Fonseca, Sandra; Rosado, Abel; Vaughan-Hirsch, John; Bishopp, Anthony; Chini, Andrea



Research on Developing and Monitoring Progress on IEP Goals: Current Findings and Implications for Practice.  

ERIC Educational Resources Information Center

Research on a system of developing and monitoring progress on individualized education program (IEP) goals has been conducted over a 5-year period at Minnesota's Institute for Research on Learning Disabilities. This research and development project is summarized by outlining the goal and rationale of the research, presenting the overall research

Wesson, Caren; And Others


Uncovering Treatment Burden as a Key Concept for Stroke Care: A Systematic Review of Qualitative Research  

PubMed Central

Background Patients with chronic disease may experience complicated management plans requiring significant personal investment. This has been termed ‘treatment burden’ and has been associated with unfavourable outcomes. The aim of this systematic review is to examine the qualitative literature on treatment burden in stroke from the patient perspective. Methods and Findings The search strategy centred on: stroke, treatment burden, patient experience, and qualitative methods. We searched: Scopus, CINAHL, Embase, Medline, and PsycINFO. We tracked references, footnotes, and citations. Restrictions included: English language, date of publication January 2000 until February 2013. Two reviewers independently carried out the following: paper screening, data extraction, and data analysis. Data were analysed using framework synthesis, as informed by Normalization Process Theory. Sixty-nine papers were included. Treatment burden includes: (1) making sense of stroke management and planning care, (2) interacting with others, (3) enacting management strategies, and (4) reflecting on management. Health care is fragmented, with poor communication between patient and health care providers. Patients report inadequate information provision. Inpatient care is unsatisfactory, with a perceived lack of empathy from professionals and a shortage of stimulating activities on the ward. Discharge services are poorly coordinated, and accessing health and social care in the community is difficult. The study has potential limitations because it was restricted to studies published in English only and data from low-income countries were scarce. Conclusions Stroke management is extremely demanding for patients, and treatment burden is influenced by micro and macro organisation of health services. Knowledge deficits mean patients are ill equipped to organise their care and develop coping strategies, making adherence less likely. There is a need to transform the approach to care provision so that services are configured to prioritise patient needs rather than those of health care systems. Systematic Review Registration International Prospective Register of Systematic Reviews CRD42011001123 Please see later in the article for the Editors' Summary PMID:23824703

Gallacher, Katie; Morrison, Deborah; Jani, Bhautesh; Macdonald, Sara; May, Carl R.; Montori, Victor M.; Erwin, Patricia J.; Batty, G. David; Eton, David T.; Langhorne, Peter; Mair, Frances S.



Participatory Action Research (PAR) in Middle School: Opportunities, Constraints, and Key Processes  

PubMed Central

Late childhood and early adolescence represent a critical transition in the developmental and academic trajectory of youth, a time in which there is an upsurge in academic disengagement and psychopathology. PAR projects that can promote youth’s sense of meaningful engagement in school and a sense of efficacy and mattering can be particularly powerful given the challenges of this developmental stage. In the present study, we draw on data from our own collaborative implementation of PAR projects in secondary schools to consider two central questions: (1) How do features of middle school settings and the developmental characteristics of the youth promote or inhibit the processes, outcomes, and sustainability of the PAR endeavor? and (2) How can the broad principles and concepts of PAR be effectively translated into specific intervention activities in schools, both within and outside of the classroom? In particular, we discuss a participatory research project conducted with 6th and 7th graders at an urban middle school as a means of highlighting the opportunities, constraints, and lessons learned in our efforts to contribute to the high-quality implementation and evaluation of PAR in diverse urban public schools. PMID:20676754

Ritterman, Miranda L.; Wanis, Maggie G.



Ten key research issues for integrated and sustainable wastewater reuse in the Middle East.  


Wastewater management is not limited to the technology used to collect and treat wastewater. It begins with the early planning phase of building a society and includes considerations of how that society will grow. Therefore, history, culture, religion, and socioeconomy are important components to include in any relevant and integrated studies of wastewater management and reuse. Engineering, health, chemistry, biology, food production, cultural heritage, and the needs of people of all ages should be considered together when making management decisions regarding issues so intimately tied with humanity as water and sanitation. Other escalating challenges such as poverty, food, and water scarcity, migration and instability, flooding and catastrophes, diseases and mortality, etc. should also be considered as part of wastewater management and reuse planning. Emerging contaminants could be associated with the urbanization, modernization, and industrialization of several countries. Several arid countries have developed water security strategies where wastewater reuse is a major component. The existing wastewater treatment technologies in these countries are, in most cases, unable to remove such contaminants which may affect irrigation waters, industrial products, groundwater, etc. People would have to accept that the food on their tables could be irrigated with treated wastewater that they generated a few months ago, even if very advanced technologies were used to treat it. The purpose of this review is to highlight multidisciplinary areas of research on wastewater and to propose applicable and affordable mechanisms by which we may consider wastewater as a legitimate resource. PMID:25427896

Shomar, Basem; Dare, Anne



Research on the effect of noise at different times of day: Models, methods and findings  

NASA Technical Reports Server (NTRS)

Social surveys of residents' responses to noise at different times of day are reviewed. Some of the discrepancies in published reports about the importance of noise at different times of day are reduced when the research findings are classified according to the type of time of day reaction model, the type of time of day weight calculated and the method which is used to estimate the weight. When the estimates of nighttime weights from 12 studies are normalized, it is found that they still disagree, but do not support stronger nighttime weights than those used in existing noise indices. Challenges to common assumptions in nighttime response models are evaluated. Two of these challenges receive enough support to warrant further investigation: the impact of changes in numbers of noise events may be less at night than in the day and nighttime annoyance may be affected by noise levels in other periods. All existing social survey results in which averages of nighttime responses were plotted by nighttime noise levels are reproduced.

Fields, J. M.



Thomas Jefferson University researchers find new biomarker to identify hepatitis B-infected patients at risk for liver cancer

Hepatitis B-infected patients with significantly longer telomeres—the caps on the end of chromosomes that protect our genetic data— were found to have an increased risk of getting liver cancer compared to those with shorter ones, according to findings presented by researchers at Jefferson’s Kimmel Cancer Center at the American Association for Cancer Research (AACR) Annual Meeting 2012.


Changing the behavior of healthcare professionals: the use of theory in promoting the uptake of research findings  

Microsoft Academic Search

Abstract Objective: The uptake of research findings into routine health care is a haphazard and unpredictable process. The usefulness of the results of implementation studies is limited, due in part to the lack of an underlying framework of the important dimensions of research studies in this area and the healthcare settings within which they are conducted,and may,subsequently be used. Study

Martin Eccles; Jeremy Grimshaw; Anne Walker; Marie Johnston; Nigel Pitts


connectMaths, Stats & OR Network E-Bulletin May 2011 Welcome to the electronic update from the Maths, Stats & OR Network for Key Departmental Contacts. We hope you find the  

E-print Network

and graded against the underlying principles below. · Student engagement ­ e.g. developing resources workshopseriestoprovidedisciplinespecificsupport, advice and guidance to postgraduate students who teach Mathematics and Statistics the Maths, Stats & OR Network for Key Departmental Contacts. We hope you find the information of interest

Davies, Christopher


Impact of Problem Finding on the Quality of Authentic Open Inquiry Science Research Projects  

ERIC Educational Resources Information Center

Problem finding is a creative process whereby individuals develop original ideas for study. Secondary science students who successfully participate in authentic, novel, open inquiry studies must engage in problem finding to determine viable and suitable topics. This study examined problem finding strategies employed by students who successfully…

LaBanca, Frank



Finding Tomorrow's Cures Northwestern University Plans for a Medical Research Facility  

E-print Network

Chicago and the city's economic development plans by bringing jobs, research, innovation, technology of Medicine conducts lifesaving research, creates jobs, fuels the Chicago economy and ensures the health of these research and patient care facilities, the hub of a world-class research and development enterprise

Contractor, Anis


“Information is Information”: A public perspective on incidental findings in clinical and research genome-based testing  

PubMed Central

Background The potential for genomic incidental findings is increasing with the use of genome-based testing. At the same time approaches to clinical decision making are shifting to shared decision-making models involving both the healthcare community and the public. The public’s voice has been nearly absent in discussions on managing incidental findings. Methods We conducted 9 focus groups and 9 interviews (N=63) with a broad cross-section of lay public groups to elucidate public viewpoints on incidental findings that could occur as a result of genome-based testing in clinical and research situations. Data were analyzed using qualitative content analysis. Results Participants wanted incidental findings disclosed to them whether or not these were clinical or research findings. Participants used different terms to define and describe incidental findings; they wanted to know that incidental findings are possible and be given a choice to learn about them. Personal utility was an important reason for disclosure, and participants believed that managing information is a shared responsibility between professionals and themselves. Conclusion Broad public input is needed in order to understand and incorporate the public’s perspective on management of incidental findings as disclosure guidelines and policies are developed in clinical and research settings. PMID:23590238

Daack-Hirsch, Sandra; Driessnack, Martha; Hanish, Alyson; Johnson, Vanessa A.; Shah, Lisa L.; Simon, Christian M.; Williams, Janet K.



Research findings working with the p53 and Rb1 targeted osteosarcoma mouse model  

PubMed Central

Osteosarcoma (OS) is the most common bone cancer in children and young adults. The etiology of osteosarcoma is currently unknown. Besides the predominant osteoblasts, the presence of cartilage forming chondrocytes within its tumor tissues suggests a role of chondrogenesis in osteosarcoma development. Runx2 is a master transcription factor both for osteoblast differentiation and for chondrocyte maturation. Interestingly, RUNX2 has been shown to directly interact with p53 and Rb1, two genes essential for osteosarcoma development in mice. However the in vivo relevance of Runx2 during osteosarcoma progression has not been elucidated. We have recently shown that targeting Runx2 expression in hypertrophic chondrocytes delays chondrocyte maturation. It has also been shown that osteoblast-specific deletion of p53 and Rb1 genes developed osteosarcoma in mice. Here, we report our recent research findings using these osteosarcoma mouse models as well as human osteosarcoma tissues. We have detected high-level RUNX2 expression in human osteoblastic osteosarcoma, while chondroblastic osteosarcoma is predominant with chondroid matrix. To minimize the effect of strain difference, we have backcrossed osterix-Cre mice onto congenic FVB/N genetic background. We also detected low-GC content (36%) in sequence around the floxed Rb1 gene and demonstrated that addition of BSA into the reaction system increases the efficiency of PCR genotyping of floxed Rb1 gene. Finally, we successfully generated multiple osteosarcoma mouse models with or without Runx2 transgenic background. These mice showed heterogeneous osteosarcoma phenotypes and marker gene expression. Characterization of these mice will facilitate understanding the role of Runx2 in osteosarcoma pathogenesis and possibly, for osteosarcoma treatment. PMID:24959378

Lu, Yaojuan; Gitelis, Steven; Lei, Guanghua; Ding, Ming; Maki, Carl; Mira, Ranim R; Zheng, Qiping



Purdue study finds "label-free" imaging tool tracks nanotubes in cells, blood for biomedical research:

Purdue University researchers have demonstrated a new imaging tool for tracking structures called carbon nanotubes in living cells and the bloodstream, which could aid efforts to perfect their use in biomedical research and clinical medicine.


Sanford-Burnham researchers find RNA molecules in urine, tissue that detect prostate cancer

Researchers at Sanford-Burnham Medical Research Institute have identified a set of RNA molecules that are detectable in tissue samples and urine of prostate cancer patients, but not in normal healthy individuals.


Everyday research in the knowledge society: who uses ICTs to find job and health information  

Microsoft Academic Search

If we take a broad definition of'research'such as'to search or examine with continued care', or'close careful study'(widely accepted meanings), then those who'research outside the walls'includes just about everyone: both those following a'academic'mode such as industrial research staff or public\\/civil servants, and those involved in other research modes, like service workers, consultants and ordinary people in'everyday life'. This report focuses on

Ben Anderson



99 Jumpstarts to Research: Topic Guides for Finding Information on Current Issues.  

ERIC Educational Resources Information Center

This book, created by three reference librarians, teaches the beginning researcher good research habits. It provides names of tools students should consult for a well-rounded, well-researched paper on a controversial issue in the news. Books, specialized databases, online resources, and agencies to contact are all included. Each "jumpstart" has…

Whitley, Peggy; Olson, Catherine; Goodwin, Susan Williams


Teachers' Approaches to Finding and Using Research Evidence: An Information Literacy Perspective  

ERIC Educational Resources Information Center

Background: The use of research evidence produced by others is seen as central to the reflective practice of school teachers. There have been many recent UK initiatives aimed at improving access to research evidence, but there are still concerns about the lack of engagement by teachers. Previous research has looked at this issue from different…

Williams, Dorothy; Coles, Louisa



Teachers' approaches to finding and using research evidence: an information literacy perspective  

Microsoft Academic Search

Background The use of research evidence produced by others is seen as central to the reflective practice of school teachers. There have been many recent UK initiatives aimed at improving access to research evidence, but there are still concerns about the lack of engagement by teachers. Previous research has looked at this issue from different perspectives, including the content and

Dorothy Williams; Louisa Coles



English-Language Teachers' Engagement with Research: Findings from Bangladesh  

ERIC Educational Resources Information Center

In this article, we report on a small-scale study in which we investigated English-language teachers' engagement with educational research. We conceptualized engagement with research as reading and systematically using research for professional development. Using questionnaires and in-depth interviews, we gathered empirical materials from 40…

Anwaruddin, Sardar M.; Pervin, Nasrin



The Ethical Maze: Finding an Inclusive Path towards Gaining Children's Agreement to Research Participation  

ERIC Educational Resources Information Center

In the UK, the ethics of engaging in sociological research directly involving children have primarily been shaped by definitions of "competence". While this has been a crucial guideline for researchers in shaping the concept of informed consent, it has also acted, perhaps inadvertently, as a way of excluding particular children from the research

Cocks, Alison J.



Florida Keys  

NASA Technical Reports Server (NTRS)

The Florida Keys are a chain of islands, islets and reefs extending from Virginia Key to the Dry Tortugas for about 309 kilometers (192 miles). The keys are chiefly limestone and coral formations. The larger islands of the group are Key West (with its airport), Key Largo, Sugarloaf Key, and Boca Chica Key. A causeway extends from the mainland to Key West.

This image was acquired on October 28, 2001, by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet.

ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products.

The broad spectral coverage and high spectral resolution of ASTER will provide scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance.

Dr. Anne Kahle at NASA's Jet Propulsion Laboratory, Pasadena, Calif., is the U.S. Science team leader; Bjorn Eng of JPL is the project manager. The Terra mission is part of NASA's Earth Science Enterprise, a long- term research effort to understand and protect our home planet. Through the study of Earth, NASA will help to provide sound science to policy and economic decision-makers so as to better life here, while developing the technologies needed to explore the universe and search for life beyond our home planet.

Size: 51.6 by 29.7 kilometers ( 32.0 by 18.4 miles) Location: 24.7 degrees North latitude, 81.5 degrees West longitude Orientation: North at top Image Data: ASTER bands 1, 2, and 3 Original Data Resolution: 15 meters (49.2 feet) Date Acquired: October 28, 2001



Key Research Results Achievement  

E-print Network

Society of North America, the U.S. Green Building Council, and NREL's Commercial Buildings Group, under and Renewable Energy, operated by the Alliance for Sustainable Energy, LLC. 15013 Denver West Parkway | Golden


Job Hunting: Where to look? This booklet aims to help you find your way around graduate employment, including key sources of graduate  

E-print Network

1 Job Hunting: Where to look? This booklet aims to help you find your way around graduate of the actual employees who work there. #12;2 Ethical careers The only website of its kind: a comprehensive guide to ethical careers, job seeking, volunteering and self-employment. The website is full

Harman, Neal.A.


Thinking Languages in L2 Writing: Research Findings and Pedagogical Implications  

ERIC Educational Resources Information Center

This article reports the findings of part of a major study exploring the disciplinary writing processes and perceptions of 15 Chinese graduate students in sciences and engineering at a major Canadian university. The findings relate to the thinking languages of the participants in writing disciplinary assignments. The study reveals that whether an…

Hu, Jim



Turning a negative into a positive: Researchers find promising use for excessive nitrate  

E-print Network

for excessive nitrate For 30 years, farmers in northwest central Texas have known that high level of nitrates in irrigation water from the Seymour Aquifer is a problem. Now, with research conducted by Texas AgriLife Research scientists, that problem may... drinking water standard of 10 parts per million, according to Texas Water Devel- opment Board data. Although that level is too high for drinking water, AgriLife researchers recently found that excess nitrate in irrigation water can be a source...

Wythe, Kathy



Returning incidental findings from genetic research to children: views of parents of children affected by rare diseases  

PubMed Central

Purpose To explore parental perceptions and experiences regarding the return of genomic incidental research findings in children with rare diseases. Methods Parents of children affected by various rare diseases were invited to participate in focus groups or individual telephone interviews in Montreal and Ottawa. Fifteen participants were interviewed and transcriptions were analysed using thematic analysis. Results Four emergent themes underscored parental enthusiasm for receiving incidental findings concerning their child's health: (1) right to information; (2) perceived benefits and risks; (3) communication practicalities: who, when, and how; and (4) service needs to promote the communication of incidental findings. Parents believed they should be made aware of all results pertaining to their child's health status, and that they are responsible for transmitting this information to their child, irrespective of disease severity. Despite potential negative consequences, respondents generally perceived a favourable risk-benefit ratio in receiving all incidental findings. Conclusions Understanding how parents assess the risks and benefits of returning incidental findings is essential to genomic research applications in paediatric medicine. The authors believe the study findings will contribute to establishing future best practices, although further research is needed to evaluate the impact of parental decisions on themselves and their child. PMID:24356209

Kleiderman, Erika; Knoppers, Bartha Maria; Fernandez, Conrad V; Boycott, Kym M; Ouellette, Gail; Wong-Rieger, Durhane; Adam, Shelin; Richer, Julie; Avard, Denise




EPA Science Inventory

This report was prepared as part of the Ohio River Basin Energy Study (ORBES), a multi-disciplinary research program supported by the Environmental Protection Agency. The extensive air quality analysis undertaken for the ORBES included examination of pollutant emissions and resul...


Clique-Finding for Heterogeneity and Multidimensionality in Biomarker Epidemiology Research: The CHAMBER Algorithm  

Microsoft Academic Search

Not Available Bibtex entry for this abstract Preferred format for this abstract (see Preferences) Find Similar Abstracts: Use: Authors Title Return: Query Results Return items starting with number Query Form Database: Astronomy Physics arXiv e-prints

Richard A. Mushlin; Stephen Gallagher; Aaron Kershenbaum; Timothy R. Rebbeck; Jonatan R. Ruiz




EPA Science Inventory

The U.S. Environmental Protection Agency is currently conducting the National Exposure Research Laboratory (NERL) Research Triangle Park (RTP) Particulate Matter (PM) Panel Study. This study represents a one year investigation of PM and related co-pollutants involving two dist...


Roswell Park-led study finds most cancer research trials do not assess participants’ tobacco use

While tobacco use can significantly hamper cancer treatment, few cancer researchers are incorporating tobacco assessment into their clinical studies. That’s the conclusion a group of investigators led by researchers at Roswell Park Cancer Institute drew from a recent survey of cancer clinical trials.


Challenges and Solutions for Libraries in Serving Entrepreneurship Needs: Findings from ProQuest Research  

Microsoft Academic Search

Many variations in programs and stages of development exist with regard to entrepreneurship in higher education academic institutions; however, there do appear to be common areas of information needed to support study, teaching, and research. To identify the information needs necessary to support the study of entrepreneurship, ProQuest undertook a comprehensive research effort in late 2006 with higher education institutions

Karen Resch Mckeown



Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science  

Microsoft Academic Search

BACKGROUND: Many interventions found to be effective in health services research studies fail to translate into meaningful patient care outcomes across multiple contexts. Health services researchers recognize the need to evaluate not only summative outcomes but also formative outcomes to assess the extent to which implementation is effective in a specific setting, prolongs sustainability, and promotes dissemination into other settings.

Laura J Damschroder; David C Aron; Rosalind E Keith; Susan R Kirsh; Jeffery A Alexander; Julie C Lowery



Classroom Teaching Skills. The Research Findings of the Teacher Education Project.  

ERIC Educational Resources Information Center

This book describes some of the research undertaken during the Teacher Education Project, a four and one-half year research and development project undertaken by the Universities of Nottingham, Leicester, and Exeter (Great Britain) and funded by the Department of Education and Science. This project involved observation of over 1,000 lessons and…

Wragg, E. C., Ed.


Research foci for career and technical education: findings from a national Delphi study  

E-print Network

for relevant and focused research for the CTE profession. The primary purpose of this study was to identify consensus among CTE experts using a Delphi technique regarding problems, objectives, and activities that serve as a research agenda for CTE. The study...

Lambeth, Jeanea Marie



A Comparative Study of International Cultural and Ethical Values: Preliminary Findings and Research Agenda  

Microsoft Academic Search

This paper describes the preliminary results of an ongoing international research project to identify the cultural values and beliefs of business students and executives in several different countries and analyze the relationship between culture and reasons behind business decisions. First, we describe a research project to assess business decisions, based on established theories of ethics. Second, we describe a model

Stephen J. J. McGuire; Angeles Lillian; Y. Fok; Kern Kwong


How College Affects Students: Findings and Insights from Twenty Years of Research.  

ERIC Educational Resources Information Center

The 14 chapters of this book review and synthesize research on the influence of college on students. Chapter 1 provides a detailed discussion of the evolution of research on college outcomes as an area of study, outlines the conceptual framework that guided the review, and provides a general overview of the study. Chapter 2 summarizes the major…

Pascarella, Ernest T.; Terenzini, Patrick T.


6- Homeless Youth in the United States: Recent Research Findings and Intervention Approaches  

Microsoft Academic Search

In this paper, the authors cite research indicating that youth may be the single age group most at risk of becoming homeless, yet comparatively little research has been done in the past decade on this vulnerable population. Some important progress has been made, including longitudinal studies on youth \\

Paul A. Toro; Amy Dworsky; Patrick J. Fowler


Nurse Practitioner competency standards: Findings from collaborative Australian and New Zealand research  

Microsoft Academic Search

Background: The title, Nurse Practitioner, is protected in most jurisdictions in Australia and New Zealand and the number of nurse practitioners is increasing in health services in both countries. Despite this expansion of the role, there is scant national or international research to inform development of nurse practitioner competency standards.Objectives: The aim of this study was to research nurse practitioner

Glenn Gardner; Jenny Carryer; Anne Gardner; Sandra Dunn



Measuring stock and change in the GB countryside for policy--key findings and developments from the Countryside Survey 2007 field survey.  


Countryside Survey is a unique large scale long-term monitoring programme investigating stock and change of habitats, landscape features, vegetation, soil and freshwaters of Great Britain. Repeat field surveys combine policy and scientific objectives to provide evidence on how multiple aspects of the environment are changing over time, a key goal of international science in the face of profound human impacts on ecosystems. Countryside Survey 2007 (CS2007), the fifth survey since 1978, retained consistency with previous surveys, whilst evolving in line with technological and conceptual advances in the collection and integration of data to understand landscape change. This paper outlines approaches taken in the 2007 survey and its subsequent analysis and presents some of the headline results of the survey and their relevance for national and international policy objectives. Key changes between 1998 and 2007 included: a) significant shifts in agricultural land cover from arable to grassland, accompanied by increases in the area of broadleaved woodland, b) decreases in the length of managed hedges associated with agricultural land, as a proportion deteriorated to lines of trees and c) increases in the areas and numbers of wet habitats (standing open water, ponds) and species preferring wetter conditions (1998-2007 and 1978-2007). Despite international policy directed at maintaining and enhancing biodiversity, there were widespread decreases in species richness in all linear and area habitats, except on arable land, consistent with an increase in competitive and late successional species between 1998 and 2007 and 1978 and 2007. Late successional and competitive species: Stinging nettle (Urtica dioica), Hawthorn (Cratageous monogyna) and Bramble (Rubus fruticosus), in the top ten recorded species recorded in 2007, all increased between 1998 and 2007. The most commonly recorded species in CS (1990, 1998 and 2007) was agricultural Ryegrass (Lolium perenne). Increases in both water quality and soil pH were in line with policy aimed at addressing previous deterioration of both. Headwater streams broadly showed continued improvements in biological quality from 1998 to 2007, continuing trends seen since 1990. In soils, there were significant increases in soil pH between 1998 and 2007 consistent with recovery from acidification. PMID:23010623

Norton, L R; Maskell, L C; Smart, S S; Dunbar, M J; Emmett, B A; Carey, P D; Williams, P; Crowe, A; Chandler, K; Scott, W A; Wood, C M



What women who use drugs have to say about ethical research: findings of an exploratory qualitative study.  


Drug users are generally seen as a vulnerable population requiring special protection in research; however, to date there has been little empirical research into the ethics of research with illicit drug users. Moreover, the available research has tended to treat "drug users" as a homogeneous category, and has failed to consider potential gender differences in users' experiences. Drawing on focus groups with twenty-seven female drug users in Vancouver, Canada, this study examines women's experiences of research and what they see as ethical and respectful engagement. Many study participants talked about feeling dehumanized as a result of prior research participation. Women were critical of the assumption that drug users lack the capacity to take part in research, and affirmed the appropriateness of financial incentives. A variety of motivations for research participation were identified, including a desire for financial gain and altruistic concerns such as a desire to help others. These findings suggest that women drug users' views on ethical research differ from prevailing assumptions among institutional review boards about how research with such populations should proceed. PMID:22228063

Bell, Kirsten; Salmon, Amy



Bonus Awards for Teachers in Texas' Performance Pay Program: Findings from the First Round of TEEG Schools. Research Brief  

ERIC Educational Resources Information Center

A recent report published by the National Center on Performance Incentives (NCPI) presents findings from the second-year of a multi-year evaluation of the Texas Educator Excellence Grant (TEEG) program, a statewide educator incentive program that operated in Texas. As part of this evaluation report, researchers examined how first-year TEEG schools…

National Center on Performance Incentives, 2009



Statement Summarizing Research Findings on the Issue of the Relationship Between Food-Additive-Free Diets and Hyperkinesis in Children.  

ERIC Educational Resources Information Center

The National Advisory Committee on Hyperkinesis and Food Additives paper summarized some research findings on the issue of the relationship between food-additive-free diets and hyperkinesis in children. Based on several challenge studies, it is concluded that the evidence generally refutes Dr. B. F. Feingold's claim that artificial colorings in…

Lipton, Morris; Wender, Esther


UTSW researchers find that inherited mutated gene raises lung cancer risk for women, those who never smoked

People who have an inherited mutation of a certain gene have a high chance of getting lung cancer — higher, even, than heavy smokers with or without the inherited mutation, according to new findings by cancer researchers at UT Southwestern Medical Center.


Finding Context: What Today's College Students Say about Conducting Research in the Digital Age. Project Information Literacy Progress Report  

ERIC Educational Resources Information Center

A report of preliminary findings and analysis from student discussion groups held on 7 U.S. campuses in Fall 2008, as part of Project Information Literacy. Qualitative data from discussions with higher education students across the country suggest that conducting research is particularly challenging. Students' greatest challenges are related to…

Head, Alison J.; Eisenberg, Michael B.



Duke researchers find that combining treatments boosts some smokers’ ability to quit

Combining two smoking cessation therapies is more effective than using just one for male and highly nicotine-dependent smokers who weren't initially helped by the nicotine patch, according to researchers at Duke Medicine.


Columbia U researchers find that generic medications boost adherence to breast cancer therapy

A study by Columbia University Medical Center researchers has found that the introduction of generic aromatase inhibitors, which are considerably less expensive than their brand-name counterparts, increased treatment adherence by 50 percent.


Duke researchers find that new immune therapy successfully treats brain tumors in mice

Using an artificial protein that stimulates the body's natural immune system to fight cancer, a research team at Duke Medicine has engineered a lethal weapon that kills brain tumors in mice while sparing other tissue.


Hopkins researchers find that a vaccine can reprogram pancreatic cancers to respond to immunotherapy

Researchers at the Johns Hopkins Kimmel Cancer Center have developed and tested a vaccine that triggered the growth of immune cell nodules within pancreatic tumors, essentially reprogramming these intractable cancers and potentially making them vulnerable to immune-based therapies.


UCSD researchers find that anti-psychotic medications offer new hope in the battle against glioblastoma

Researchers at the University of California, San Diego School of Medicine have discovered that FDA-approved anti-psychotic drugs possess tumor-killing activity against the most aggressive form of primary brain cancer, glioblastoma.


MIT researchers find a new way to model cancer using mice

One way to discover the role of the mutations is to breed a strain of mice that carry the genetic flaw — but breeding such mice is an expensive, time-consuming process. Now, MIT researchers have found an alternative.



EPA Science Inventory

The Detroit Exposure and Aerosol Research Study (DEARS) has completed its first monitoring season (summer 2005) and is progressing toward initiation of its second season (February 2005). The assistance obtained from the Michigan Department of Environmental Quality has been instr...


UPenn researchers find radiation plus hormone therapy prolongs survival for older men with prostate cancer

Adding radiation treatment to hormone therapy saves more lives among older men with locally advanced prostate therapy than hormone therapy alone, according to a new study in the Journal of Clinical Oncology this week from Penn Medicine researchers.


UC Davis research finds newer radiation therapy technology improves patients' quality of life:

Patients with head and neck cancers who have been treated with newer, more sophisticated radiation therapy technology enjoy a better quality of life than those treated with older radiation therapy equipment, a study by UC Davis researchers has found.


Money for Research, Not Energy Bills: Finding Energy and Cost Savings in  

E-print Network

machines also rise--sometimes to startling levels. For example, the U.S. Department of Energy (DOE, energy-efficiency, Computational Research and Theory Facility, CRTF, University of California, facility. Just as residen


UCLA researchers find intestinal bacteria are linked to white blood cell cancer

Researchers from UCLA's Jonsson Comprehensive Cancer Center have discovered that specific types of bacteria that live in the gut are major contributors to lymphoma, a cancer of the white blood cells that are part of the human immune system.


Moffitt researchers find potential new therapeutic target for treating non-small cell lung cancer

Researchers at Moffitt Cancer Center have found a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer. It is based on the newly identified oncogene IKBKE, which helps regulate immune response.


Harvard and Baylor researchers find new target for aggressive cancer gene:

Researchers have found a way to kill human cells hijacked by a genetic accelerator that puts cancer cells into overdrive: the Myc oncogene. The discovery reveals new drug targets for Myc-driven cancers, which tend to be particularly aggressive.


UTHSC researchers find that improved screening means new targets for pediatric neuroblastoma therapies

A researcher at the University of Texas Health Science Center at San Antonio unveils the important role of microRNAs in regulating neuroblastoma development, pointing to new therapeutic possibilities.


UCLA researchers find that lens-free microscope can detect cancer at the cellular level

UCLA researchers have developed a lens-free microscope that can be used to detect the presence of cancer or other cell-level abnormalities with the same accuracy as larger and more expensive optical microscopes.


Hopkins researchers find that a new cancer-fighting strategy would harden cells to prevent metastasis

Existing cancer therapies are geared toward massacring tumor cells, but Johns Hopkins researchers propose a different strategy: subtly hardening cancer cells to prevent them from invading new areas of the body.


Hunstman researchers find that a rare cancer exposes possible route to new treatments

Researchers from Huntsman Cancer Institute at the University of Utah discovered the unusual role of lactate in the metabolism of alveolar soft part sarcoma, a rare, aggressive cancer that primarily affects adolescents and young adults.


UCLA researchers develop new screening system to find brain cancer stem cell killers:

Researchers with UCLA’s Jonsson Comprehensive Cancer Center have developed and used a high-throughput molecular screening approach that identifies and characterizes chemical compounds that can target the stem cells that are responsible for creating deadly brain tumors.


Columbia University researchers find that severing nerves in mice may shrink stomach cancers

Research from Columbia University Medical Center shows that nerves may play a critical role in stomach cancer growth and that blocking nerve signals using surgery or Botox (onabotulinumtoxinA) could be an effective treatment for the disease.


NIH Researchers Find Resveratrol Helps Protect Against Diabetes in Animal Study  


... the body cannot regulate its blood sugar. Rhesus monkeys were fed either a standard diet, a high ... 24 months. Researchers found that the islets of monkeys on a high fat/high sugar diet supplemented ...


Emerging Answers: Research Findings on Programs to Reduce Teen Pregnancy (Summary)  

NSDL National Science Digital Library

Released on May 30, 2001, by the National Campaign to Prevent Teen Pregnancy, this new report by Dr. Douglas Kirby reviews some 250 studies on teen pregnancy programs. The review finds that long-term programs have made a genuine difference in teen pregnancy, abortion, and birth rates, the last of which is now at its lowest level recorded. Kirby's study also finds no evidence that "abstinence-only" programs are effective or that sex education that covers contraception increases sexual activity. At the site, visitors may download a 21-page summary of the report, the press release, a FAQ, and related information.

Kirby, Douglas



Procedures of recruiting, obtaining informed consent, and compensating research participants in Qatar: findings from a qualitative investigation  

PubMed Central

Background Very few researchers have reported on procedures of recruiting, obtaining informed consent, and compensating participants in health research in the Arabian Gulf Region. Empirical research can inform the debate about whether to adjust these procedures for culturally diverse settings. Our objective was to delineate procedures related to recruiting, obtaining informed consent, and compensating health research participants in the extremely high-density multicultural setting of Qatar. Methods During a multistage mixed methods project, field observations and qualitative interviews were conducted in a general medicine clinic of a major medical center in Qatar. Participants were chosen based on gender, age, literacy, and preferred language, i.e., Arabic, English, Hindi and Urdu. Qualitative analysis identified themes about recruitment, informed consent, compensation, and other research procedures. Results A total of 153 individuals were approached and 84 enrolled; the latter showed a diverse age range (18 to 75 years); varied language representation: Arabic (n?=?24), English (n?=?20), Hindi (n?=?20), and Urdu (n?=?20); and balanced gender distribution: women (n?=?43) and men (n?=?41). Primary reasons for 30 declinations included concern about interview length and recording. The study achieved a 74% participation rate. Qualitative analytics revealed key themes about hesitation to participate, decisions about participation with family members as well as discussions with them as “incidental research participants”, the informed consent process, privacy and gender rules of the interview environment, reactions to member checking and compensation, and motivation for participating. Vulnerability emerged as a recurring issue throughout the process among a minority of participants. Conclusions This study from Qatar is the first to provide empirical data on recruitment, informed consent, compensation and other research procedures in a general adult population in the Middle East and Arabian Gulf. This investigation illustrates how potential research participants perceive research participation. Fundamentally, Western ethical research principles were applicable, but required flexibility and culturally informed adaptations. PMID:24495499



Informed consent for exome sequencing research in families with genetic disease: the emerging issue of incidental findings.  


Genomic sequencing technology is increasingly used in genetic research. Studies of informed consent for exome and genome sequencing (ES/GS) research have largely involved hypothetical scenarios or healthy individuals enrolling in population-based studies. Studies have yet to explore the consent experiences of adults with inherited disease. We conducted a qualitative interview study of 15 adults recently enrolled in a large-scale ES/GS study (11 affected adults, four parents of affected children). Our study had two goals: (1) to explore three theoretical barriers to consent for ES/GS research (interpretive/technical complexity, possibility of incidental findings, and risks of loss of privacy); and (2) to explore how interviewees experienced the consent process. Interviewees could articulate study goals and processes, describe incidental findings, discuss risks of privacy loss, and reflect on their consent experience. Few expected the study would identify the genetic cause of their condition. All elected to receive incidental findings. Interviewees acknowledged paying little attention to potential implications of incidental findings in light of more pressing goals of supporting research regarding their own medical conditions. Interviewees suggested that experience living with a genetic condition prepared them to adjust to incidental findings. Interviewees also expressed little concern about loss of confidentiality of study data. Some experienced the consent process as very long. None desired reconsent prior to return of study results. Families with inherited disease likely would benefit from a consent process in which study risks and benefits were discussed in the context of prior experiences with genetic research and genetic disease. PMID:25251809

Bergner, Amanda L; Bollinger, Juli; Raraigh, Karen S; Tichnell, Crystal; Murray, Brittney; Blout, Carrie Lynn; Telegrafi, Aida Bytyci; James, Cynthia A



DCCPS: BRP: HBRB: Key Initiatives

Skip Navigation Twitter Multimedia Home About Key Initiatives Funding Resources Tools Cancer Control & Population Sciences Home Behavioral Research Program Home Health Behaviors Research Branch Health Behaviors Research Branch (HBRB) Key Initiatives Transdisciplinary


Conclusions: Overview of Findings from the ERA Study, Inferences, and Research Implications  

ERIC Educational Resources Information Center

In this monograph, the authors have brought the findings of the English and Romanian Adoptee (ERA) study up to age 15 years and, in so doing, have focused especially on the question of whether there are deprivation-specific psychological patterns (DSPs) that differ meaningfully from other forms of psychopathology. For this purpose, their main…

Rutter, Michael; Sonuga-Barke, Edmund J.



Private Equity vs. PLC Boards: A Comparison of Practices and Effectiveness - Summary of Research Findings  

Microsoft Academic Search

We interview 20 executives in the UK who have been members of both PE and PLC boards of relatively large companies. The main difference we find in PE and PLC board modus operandi is in the single-minded value creation focus of PE boards versus governance compliance and risk management focus of PLC boards. PE boards see their role as \\

Viral V. Acharya; Conor Kehoe; Michael Reyner



Job Placement Systems for Older Workers. Volume One: Research Findings, Case Studies, Program Models.  

ERIC Educational Resources Information Center

This report describes a study that was undertaken to examine placement techniques and strategies that are effective in helping older workers find jobs. The study presents 23 case studies on successful older worker programs in 12 states. The information was gathered through on-site interviews and assembly of quantitative data. These case studies…

National Caucus and Center on Black Aged, Inc., Washington, DC.


Fox Chase researchers find that most Medicare patients wait weeks before breast cancer surgery

Although patients may feel anxious waiting weeks from the time of their first doctor visit to evaluate their breast until they have breast cancer surgery, new findings from Fox Chase Cancer Center show that these waits are typical in the United States. Results were published on Monday, November 19 in the Journal of Clinical Oncology.


Advancing care for traumatic brain injury: findings from the IMPACT studies and perspectives on future research.  


Research in traumatic brain injury (TBI) is challenging for several reasons; in particular, the heterogeneity between patients regarding causes, pathophysiology, treatment, and outcome. Advances in basic science have failed to translate into successful clinical treatments, and the evidence underpinning guideline recommendations is weak. Because clinical research has been hampered by non-standardised data collection, restricted multidisciplinary collaboration, and the lack of sensitivity of classification and efficacy analyses, multidisciplinary collaborations are now being fostered. Approaches to deal with heterogeneity have been developed by the IMPACT study group. These approaches can increase statistical power in clinical trials by up to 50% and are also relevant to other heterogeneous neurological diseases, such as stroke and subarachnoid haemorrhage. Rather than trying to limit heterogeneity, we might also be able to exploit it by analysing differences in treatment and outcome between countries and centres in comparative effectiveness research. This approach has great potential to advance care in patients with TBI. PMID:24139680

Maas, Andrew I R; Murray, Gordon D; Roozenbeek, Bob; Lingsma, Hester F; Butcher, Isabella; McHugh, Gillian S; Weir, James; Lu, Juan; Steyerberg, Ewout W



The North American long-term soil productivity experiment: Findings from the first decade of research  

Microsoft Academic Search

First decade findings on the impacts of organic matter removal and soil compaction are reported for the 26 oldest installations in the nation-wide network of long-term soil productivity sites. Complete removal of surface organic matter led to declines in soil C concentration to 20cm depth and to reduced nutrient availability. The effect is attributed mainly to the loss of the

Robert F. Powers; D. Andrew Scott; Felipe G. Sanchez; Richard A. Voldseth; Deborah Page-Dumroese; John D. Elioff; Douglas M. Stone



Georgetown researchers examine nipple sparing mastectomy cases and find no recurrent or new cancers:

A new study suggests some women needing a lumpectomy or mastectomy to treat their breast cancer have another potential option that is safe and effective, say researchers at Georgetown. They say the procedure known as a nipple sparing mastectomy is also a viable surgical option for women who choose to have their breasts removed because of their increased risk of developing the disease.


Stress, Coping and Burnout in Mental Health Nurses: Findings From Three Research Studies  

Microsoft Academic Search

In this paper we present data from three research studies on stress, coping and burnout in mental health nurses. All three studies used a range of self report questionnaires. Measures included a demographic checklist, the General Health Questionnaire (GHQ-28), the Maslach Burnout Inventory, the DCL Stress Scale and the Cooper Coping Skills Scale. In all, 648 ward based mental health

Leonard Fagin; Jerome Carson; John Leary; Nicolette De Villiers; Heather Bartlett; Patty OMalley; Maria West; Stephen Mcelfatrick; Daniel Brown



U of Michigan researchers find that new sequencing technique reveals genetic clues to rare breast tumors

A new study from researchers at the University of Michigan Comprehensive Cancer Center characterizes the genetic underpinnings of a rare type of breast tumor called phyllodes tumors, offering the first comprehensive analysis of the molecular alterations at work in these tumors.


Better Together: Research Findings on the Relationship between Racial Justice Organizations and LGBT Communities. Report  

ERIC Educational Resources Information Center

In partnership with the Arcus Foundation, the Applied Research Center (ARC) has undertaken a study of the relationship between racial justice organizations and lesbian/gay/bisexual/transgender (LGBT) constituencies and issues, with the understanding that communities of color themselves, including their LGBT members, have a good deal at stake in…

Sen, Rinku; Wessler, Seth; Apollon, Dominique



The ABCs of Keeping on Track to Graduation: Research Findings from Baltimore  

ERIC Educational Resources Information Center

This study of graduation outcomes in Baltimore uses multivariate analysis of longitudinal student cohort data to examine the impact of factors identified in previous research as early warning indicators of a dropout outcome. Student cohort files were constructed from longitudinal administrative data (following all first-time 2004-2005 and…

Mac Iver, Martha Abele; Messel, Matthew



Column: Two examples of researchers finding amazing things by reconsidering the fundamentals.  

E-print Network

did that with cement, it found that what scientists thought they knew about the fundamental structure on the use of magnetic materials. Think computer hard drives. In spelling out the details of this research Proceedings of the National Academy of Sciences. Add water to cement powder and it forms a paste called cement


Census of Institutional Repositories in the United States: MIRACLE Project Research Findings. CLIR Publication No. 140  

ERIC Educational Resources Information Center

In this report, the authors describe results of a nationwide census of institutional repositories in U.S. academic institutions. The census is one of several activities of the MIRACLE Project, an Institute of Museum and Library Services (IMLS)-funded research program based at the University of Michigan. The acronym MIRACLE means "Making…

Markey, Karen; Rieh, Soo Young; St. Jean, Beth; Kim, Jihyun; Yakel, Elizabeth



Jefferson researchers find that cancer information on Wikipedia is accurate, but not very readable:

It is a commonly held that information on Wikipedia should not be trusted, since it is written and edited by non-experts without professional oversight. But researchers from the Kimmel Cancer Center at Jefferson have found differently, according to a study published online Sept. 15 in the Journal of Oncology Practice.


Social and Emotional Distress among American Indian and Alaska Native Students: Research Findings. ERIC Digest.  

ERIC Educational Resources Information Center

Many American Indian and Alaska Native (AI/AN) youth are repeatedly exposed to opportunities to participate in self-destructive and illegal behaviors. This digest examines risk factors associated with four contexts: peers, family, school, and community. Recent research has shown that, relative to national averages, AI/AN youth have higher rates of…

Clarke, Ardy SixKiller


Kimmel Cancer Center researchers find drugs targeting chromosomal instability may fight a particular breast cancer subtype

A team of researchers at Jefferson's Kimmel Cancer Center has shown in a study published online Feb. 6 in the Journal of Clinical Investigation that the oncogene cyclin D1 may promote a genetic breakdown known as chromosomal instability (CIN). CIN is a known, yet poorly understood culprit in tumor progression.


Penn researchers find contralateral prophylactic mastectomy offers limited gains to life expectancy for breast cancer patients:

Contralateral prophylactic mastectomy (CPM), a procedure that removes the unaffected breast in patients with cancer in one breast, provides only a modest increase in life expectancy, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania.


Georgetown researchers find that landmark Medicare law had little impact on reducing chemotherapy cost

Legislation passed in 2003 to slow the spiraling costs of drugs paid for by the federal government to treat Medicare patients has had no meaningful impact on cancer chemotherapy drug costs, say a team of researchers in the Journal of Clinical Oncology published online today.


UNC and other researchers find that gene expression improves the definition of a breast cancer subtype

A study conducted by the Vall d'Hebron Institute of Oncology in conjunction with the GEICAM cooperative group and other American and Canadian researchers, including UNC, has led to a change in the definition of hormone-sensitive breast tumors


Moffitt research finds no survival advantage for stem cell versus bone marrow transplant

Researchers at Moffitt Cancer Center, and colleagues in the Blood and Marrow Transplant Clinical Trials Network conducted a two-year clinical trial comparing two-year survival probabilities for patients transplanted with peripheral blood stem cells or bone marrow stem cells from unrelated donors and found no survival advantage for one method over the other.


University of Wisconsin researchers find a new form of cell division

Researchers at the University of Wisconsin Carbone Cancer Center have discovered a new form of cell division in human cells. They believe it serves as a natural back-up mechanism during faulty cell division, preventing some cells from going down a path that can lead to cancer.


Resources. Some Findings and Conjectures from Recent Research into Resource Development and Use.  

ERIC Educational Resources Information Center

The triannual newsletter, "Resources", published by Resources for the Future (RfF) typically contains excerpts from recent research in the area of natural resource development, conservation, and use. Announcements are also made of recent publications by RfF. Those interested in receiving the newsletter regularly should request that their name be…

Resources for the Future, Inc., Washington, DC.


University of Washington researchers find community effort brings lasting drop in smoking, delinquency, drug use:

Tenth graders in towns using Communities That Care [a prevention system developed by University of Washington researchers] were less likely to have tried drinking or smoking compared with teens living in towns that had not adopted the system. Delinquent behavior, including stealing, vandalism and physical fights, decreased too.


UCSD researchers find that chili peppers may inhibit gut tumors in mice

Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin – the active ingredient in chili peppers – produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal tumors.


Hopkins researchers find that blood test for 'nicked' protein predicts prostate cancer treatment response

Prostate cancer patients whose tumors contain a shortened protein called AR-V7, which can be detected in the blood, are less likely to respond to two widely used drugs for metastatic prostate cancer, according to results of a study led by researchers at the Johns Hopkins Kimmel Cancer Center.


The Meaning of Work among Chinese University Students: Findings from Prototype Research Methodology  

ERIC Educational Resources Information Center

This study examined Chinese university students' conceptualization of the meaning of work. One hundred and ninety students (93 male, 97 female) from Beijing, China, participated in the study. Prototype research methodology (J. Li, 2001) was used to explore the meaning of work and the associations among the identified meanings. Cluster analysis was…

Zhou, Sili; Leung, S. Alvin; Li, Xu



Finding Voice through Teacher-Student Collaboration in a Feminist Research Project: Long-Term Effects.  

ERIC Educational Resources Information Center

In a feminist classroom an instructor who acts as an "interested party" rather than an authority, fosters an environment of care and connection which can result in life-changing discoveries for the participants. Drawing on David Bleich's conception of a "socially generous research" that removes hierarchical barriers between teacher and student, a…

Fey, Marion Harris


Domestic Violence Between Same-Gender Partners: Recent Findings and Future Research  

ERIC Educational Resources Information Center

Empirical literature about same-gender domestic violence was relatively nonexistent until the past 20 years, and conducting research with this population about a sensitive topic remains a daunting endeavor. Existing studies reveal similarities between opposite- and same-gender domestic violence in prevalence, types of abuse, and various dynamics,…

McClennen, Joan C.



Northwestern researchers find lower dosage CT-guided lung biopsy protocol maintains quality, minimizes exposure

New guidelines for CT-guided biopsies of lung nodules significantly reduce radiation exposure allowing individuals the benefit of the procedure, which may cut down on overall lung cancer deaths. This research is being presented at the Society of Interventional Radiology's 37th Annual Scientific Meeting in San Francisco, Calif.


MD Anderson researchers find that chemotherapy is as effective before breast cancer surgery as after

Whether chemotherapy is given before or after breast-conserving therapy does not have an impact on long-term local-regional outcomes, suggesting treatment success is due more to biologic factors than chemotherapy timing, according to a study by researchers at The University of Texas MD Anderson Cancer Center.


The influence of organic production on food quality - research findings, gaps and future challenges.  


Although several meta-analysis studies have been published comparing the quality of food derived from organic and non-organic origin, it is still not clear if food from organic production per se can guarantee product-related added value to consumers. This paper aims to summarize the status quo in order to identify research gaps and suggest future research challenges. Organic food is described according to a quality model already published. The influence of organic production on food quality is structured in primary production and processing. Furthermore, organic food authentication is discussed. Organic food seems to contain fewer pesticide residues and statistically more selected health-related compounds such as polyphenols in plant products and polyunsaturated fatty acids in milk and meat products, but the health relevance for consumers is not clear yet. Comparing food from organic origin with so called 'conventional' food seems not to be appropriate, because 'conventional' is not defined. In organic food quality research a system approach is needed from which systemic markers can be selected. Research on the impact of processing technologies on the quality according to organic principles seems of high relevance, since most of the food is processed. PMID:24436145

Za??cka, Aneta; Bügel, Susanne; Paoletti, Flavio; Kahl, Johannes; Bonanno, Adriana; Dostalova, Anne; Rahmann, Gerold



Strategies for Improving Rehearsal Technique: Using Research Findings to Promote Better Rehearsals  

ERIC Educational Resources Information Center

Music education researchers and conducting pedagogues have identified numerous behaviors that contribute to increased verbal and nonverbal teaching effectiveness of conductors on the podium. This article is a review of literature concerning several conductor behaviors that may (a) increase the effectiveness of rehearsals, (b) enhance the…

Silvey, Brian A.



Penn researchers find Epstein Barr-like virus infects and may cause cancer in dogs

...A team of researchers from the University of Pennsylvania School of Veterinary Medicine and Penn's Perelman School of Medicine has the first evidence that an Epstein Barr-like virus can infect and may also be responsible for causing lymphomas in man's best friend.


Washington University researchers find that mass prostate cancer screenings don’t reduce death:

There’s new evidence that annual prostate cancer screening does not reduce deaths from the disease, even among men in their 50s and 60s and those with underlying health conditions, according to new research led by Washington University School of Medicine in St. Louis.


Johns Hopkins researchers find that chronic inflammation is linked to high-grade prostate cancer

Men who show signs of chronic inflammation in non-cancerous prostate tissue may have nearly twice the risk of actually having prostate cancer than those with no inflammation, according to results of a new study led by researchers from the Johns Hopkins Kimmel Cancer Center.


NASA Research Focuses on Yellowstone's Hot Springs and Compares Findings to Rocks from Mars  

NSDL National Science Digital Library

This NASA Astrobiology Institute website features an article by the Yellowstone Park Foundation focusing on NASA's latest thermophile research and its contributions to outreach education in Yellowstone National Park. The site also provides a number of useful links through the NAI portal site including a teacher's page, student's page, and additional NAI articles and newsletters.

Foundation, Yellowstone P.; Institute, Nasa A.


New Study Finds Increasing Gender Equity at U.S. Research Institutions  

NASA Astrophysics Data System (ADS)

Women and men faculty in science, engineering, and mathematics for the most part have comparable opportunities within major U.S. research universities, according to a report released 2 June by the U.S. National Research Council (NRC). The report found that gender does not appear to have been a factor in a number of important career transitions and outcomes, including hiring for tenure track and tenure positions and promotions. “That is probably going to be surprising to many people. It was surprising to our own panel. And it may not have been the case if we had done the study in 1985 instead of 2005,” said Claude Canizares, cochair of the NRC committee that prepared the report, entitled Gender Differences at Critical Transitions in the Careers of Science, Engineering and Mathematics Faculty.

Showstack, Randy



The meaning of work among Chinese university students: findings from prototype research methodology.  


This study examined Chinese university students' conceptualization of the meaning of work. One hundred and ninety students (93 male, 97 female) from Beijing, China, participated in the study. Prototype research methodology (J. Li, 2001) was used to explore the meaning of work and the associations among the identified meanings. Cluster analysis was used to organize the identified meanings into a structure consisting of lateral and hierarchical levels. The themes that emerged fell into 2 large categories named "ideal" and "reality." A series of superordinate-level and basic-level prototypes were found under each of these 2 categories. These prototypes reflected influences from both Chinese traditional and Western value orientations, as well as perceptions that are to be understood in the contemporary social and economic contexts of China. Implications for career development theory, research, and practice are discussed. PMID:22774866

Zhou, Sili; Leung, S Alvin; Li, Xu



Hopkins researchers find that cancer cells feed on sugar-free diet:

Cancer cells have been long known to have a “sweet tooth,” using vast amounts of glucose for energy and for building blocks for cell replication.   Now, a study by a team of researchers at Johns Hopkins and elsewhere shows that lymph gland cancer cells called B cells can use glutamine in the absence of glucose for cell replication and survival, particularly under low-oxygen conditions, which are common in tumors.


Emory University researchers find new pathway for regulation of blood vessel growth in cancer

Researchers at Winship Cancer Institute of Emory University have identified a new function for a gene that normally prevents the development of cancer. Scientists had known that the gene, which encodes a protein called p14 ARF, works inside the cell to control proliferation and division. The Winship team discovered that p14 ARF also regulates tumor-induced angiogenesis, the process by which growing cancers attract new blood vessels.


Stanford University researchers find that dual-action protein better restricts blood vessel formation:

In a paper published online Aug. 8 in the Proceedings of the National Academy of Sciences, researchers at Stanford University describe the creation of a new type of engineered protein that is significantly more effective at preventing the formation of blood vessels by targeting not one, but two of the chemical receptors that control the creation of new capillaries -- a process known as angiogenesis. The study shows that the new protein blocks both receptors.


UCBerkeleyNews: Cables Hold Promise in Protecting Existing Buildings from Bombs, Researchers Find  

NSDL National Science Digital Library

A civil engineering professor at the University of California at Berkeley is working on a novel way of maintaining a building's structural stability after an earthquake or terrorist bomb. The team of researchers working with the professor have designed and tested a system that uses cables for backup support in case main support beams failed. An overview of the system is provided in a February 20, 2003 news article.

Yang, Sarah.



UC San Diego researchers find an enzyme that offers new therapeutic target for cancer drugs

Researchers at the University of California, San Diego School of Medicine have uncovered a new signal transduction pathway specifically devoted to the regulation of alternative RNA splicing, a process that allows a single gene to produce or code multiple types of protein variants. The discovery, published in the June 27, 2012 issue of Molecular Cell, suggests the new pathway might be a fruitful target for new cancer drugs. The University of California, San Diego is home to the Moores Comprehensive Cancer Center.


New findings and setting the research agenda for soil and water conservation for sustainable land management  

NASA Astrophysics Data System (ADS)

The session on soil and water conservation for sustainable land management provides insights into the current research producing viable measures for sustainable land management and enhancing the lands role as provider of ecosystem services. The insights into degradation processes are essential for designing and implementing feasible measures to mitigate against degradation of the land resource and adapt to the changing environment. Land degradation occurs due to multiple pressures on the land, such as population growth, land-use and land-cover changes, climate change and over exploitation of resources, often resulting in soil erosion due to water and wind, which occurs in many parts of the world. Understanding the processes of soil erosion by wind and water and the social and economic constraints faced by farmers forms an essential component of integrated land development projects. Soil and water conservation measures are only viable and sustainable if local environmental and socio-economic conditions are taken into account and proper enabling conditions and policies can be achieved. Land degradation increasingly occurs because land use, and farming systems are subject to rapid environmental and socio-economic changes without implementation of appropriate soil and water conservation technologies. Land use and its management are thus inextricably bound up with development; farmers must adapt in order to sustain the quality of their, and their families, lives. In broader perspective, soil and water conservation is needed as regulating ecosystem service and as a tool to enhance food security and biodiversity. Since land degradation occurs in many parts of the world and threatens food production and environmental stability it affects those countries with poorer soils and resilience in the agriculture sector first. Often these are the least developed countries. Therefore the work from researchers from developing countries together with knowledge from other disciplines and places is essential if we are to develop viable measures and approaches to soil and water conservation across the globe. In this paper we will provide an overview of the topics that are addressed in this session and give an overview of the current research in this field and using the insights we will aim to present a new research agenda oriented towards a significant impact in economic and environmental sustainability.

Keesstra, Saskia; Argaman, Eli; Gomez, Jose Alfonso; Quinton, John



Incidental findings in data-intensive postgenomics science and legal liability of clinician-researchers: ready for vaccinomics?  


Vaccinomics encompasses a host of multiomics approaches to characterize variability in host-environment (including pathogens) interactions, with a view to a more directed or personalized use of vaccine-based health interventions. Although vaccinomics has the potential to reduce adverse effects and increase efficacy of vaccines, the use of high-throughput, data-intensive technologies may also lead to unanticipated discoveries beyond the initial aims of a vaccinomics study--discoveries that could be highly significant to the health of the research participants. How do clinician-researchers faced with such information have to act? What are the attendant legal duties in such circumstances and how do they differ from the duties of non-clinician researchers? Together with a critical analysis of the international laws and policies framing researchers' duties with regard to incidental findings, this article also draws from Quebec's civil law--with its rich jurisprudence on clinician and researcher liability--as a case study to evaluate the potential legal implications associated with vaccinomics investigations. Given previous lessons learned from other data-intensive sciences, the education of clinician-researchers with regard to their roles, limitations, and legal obligations remains an important strategy to prevent potential legal complications and civil liability in vaccinomics research in the postgenomics era. PMID:21728813

Zawati, Ma'n H; Hendy, Matthew; Joly, Yann



Communicating Experimental Findings in Single Case Design Research: How to Use Celeration Values and Celeration Multipliers to Measure Direction, Magnitude, and Change of Slope  

ERIC Educational Resources Information Center

The accumulation of scientific knowledge greatly depends upon the critical review of experimental findings by ones peers. In single case design research, experimenters present findings with graphical displays of data and narrative description of a visual analysis. To aid in efficient and accurate description of experimental findings, the research

Datchuk, Shawn M.; Kubina, Richard M., Jr.



The educational gradient in marital disruption: a meta-analysis of European research findings.  


A large number of empirical studies have investigated the effects of women's education on union dissolution in Europe, but results have varied substantially. This paper seeks to assess the relationship between educational attainment and the incidence of marital disruption by systematizing the existing empirical evidence. A quantitative literature review (a meta-analysis) was conducted to investigate the temporal change in the relationship, net of inter-study differences. The results point to a weakening of the positive educational gradient in marital disruption over time and even to a reversal in the direction of this gradient in some countries. The findings also show that the change in the educational gradient can be linked to an increase in access to divorce. Finally, the results suggest that women's empowerment has played an important role in changing the educational gradient, while the liberalization of divorce laws has not. PMID:24279466

Matysiak, Anna; Styrc, Marta; Vignoli, Daniele



Microdialysis in equine research: a review of clinical and experimental findings.  


Microdialysis is a method for sampling compounds from extracellular fluid with minimal tissue trauma. Small hollow probes that are 0.2-0.5mm in diameter are inserted into the tissue and slowly perfused. The probe membrane is semi-permeable and a flux of the solutes occurs exclusively according to the concentration gradients. The recovered dialysate reflects changes in the composition of the extracellular water phase with a minor time delay. Because microdialysis is a continuous sampling method, it differs from point sample methods, such as blood sampling. The ability to obtain local measurements in the tissues has led to important discoveries in the detection of tissue changes within the areas of pharmacokinetics, pharmacodynamics, pathology and pathophysiology. New technological solutions, such as transportable pumps, fluid collectors and bedside analysers, have made microdialysis an indispensable tool for the surveillance of critically ill human patients, such as after brain injuries and reconstructive surgeries. The use of microdialysis in equine medicine has been sparingly described with only 14 published studies within muscle, pulmonary and hoof lamellar tissue, nasal mucosa, intestinal wall, uterine, allantoic and cerebrospinal fluid and blood. Only a few papers have been published within each area, indicating that few equine researchers are aware of the unique opportunities provided by the technique. This review discusses the theory and applications of microdialysis with a special emphasis on clinical and experimental equine studies, which may be useful to veterinary experimental and clinical researchers. PMID:23660155

Sørensen, M A; Jacobsen, S; Petersen, L J



PLUME-FEATHER, Referencing and Finding Software for Research and Education  

NASA Astrophysics Data System (ADS)

PLUME-FEATHER is a non-profit project created to Promote economicaL, Useful and Maintained softwarEFor theHigher Education And THE Research communities. The site references software, mainly Free/Libre Open Source Software (FLOSS) from French universities and national research organisations, (CNRS, INRA...), laboratories or departments as well as other FLOSS software used and evaluated by users within these institutions. Each software is represented by a reference card, which describes origin, aim, installation, cost (if applicable) and user experience from the point of view of an academic user for academic users. Presently over 1000 programs are referenced on PLUME by more than 900 contributors. Although the server is maintained by a French institution, it is open to international contributions in the academic domain. All contained and validated contents are visible to anonymous public, whereas (presently more than 2000) registered users can contribute, starting with comments on single software reference cards up to help with the organisation and presentation of the referenced software products. The project has been presented to the HEP community in 2012 for the first time [1]. This is an update of the status and a call for (further) contributions.

Bénassy, O.; Caron, C.; Ferret-Canape, C.; Cheylus, A.; Courcelle, E.; Dantec, C.; Dayre, P.; Dostes, T.; Durand, A.; Facq, A.; Gambini, G.; Geahchan, E.; Helft, C.; Hoffmann, D.; Ingarao, M.; Joly, P.; Kieffer, J.; Larré, J.-M.; Libes, M.; Morris, F.; Parmentier, H.; Pérochon, L.; Porte, O.; Romier, G.; Rousse, D.; Tournoy, R.; Valeins, H.



PLUME-FEATHER, Referencing and Finding Software for Research and Education  

NASA Astrophysics Data System (ADS)

PLUME-FEATHER is a non-profit project created to Promote economicaL, Useful and Maintained softwarE For the Higher Education And THE Research communities. The site references software, mainly Free/Libre Open Source Software (FLOSS) from French universities and national research organisations, (CNRS, INRA…), laboratories or departments as well as other FLOSS software used and evaluated by users within these institutions. Each software is represented by a reference card, which describes origin, aim, installation, cost (if applicable) and user experience from the point of view of an academic user for academic users. Presently over 1000 programs are referenced on PLUME. Although the server is maintained by a french institution, it is completely open to international contributions in the academic domainb. All contained and validated contents are visible to anonymous public, whereas registered users can contribute, starting with comments on single software reference cards up to help with the organisation and presentation of the referenced software products. This first presentation is call for (further) contributions from the HEP community.

Hoffmann, Dirk; Romier, Geneviève



Disaster media coverage and psychological outcomes: descriptive findings in the extant research.  


This review of the literature on disaster media coverage describes the events, samples, and forms of media coverage (television, newspapers, radio, internet) studied and examines the association between media consumption and psychological outcomes. A total of 36 studies representing both man-made and natural events met criteria for review in this analysis. Most studies examined disaster television viewing in the context of terrorism and explored a range of outcomes including posttraumatic stress disorder (PTSD) caseness and posttraumatic stress (PTS), depression, anxiety, stress reactions, and substance use. There is good evidence establishing a relationship between disaster television viewing and various psychological outcomes, especially PTSD caseness and PTS, but studies are too few to draw definitive conclusions about the other forms of media coverage that have been examined. As media technology continues to advance, future research is needed to investigate these additional media forms especially newer forms such as social media. PMID:25064691

Pfefferbaum, Betty; Newman, Elana; Nelson, Summer D; Nitiéma, Pascal; Pfefferbaum, Rose L; Rahman, Ambreen



Enhancing the Participation of African Americans in Health-Related Genetic Research: Findings of a Collaborative Academic and Community-Based Research Study  

PubMed Central

The involvement of African Americans in research has long been expressed as a concern by the scientific community. While efforts have been undertaken to identify factors inhibiting the participation of African Americans in health-related research, few efforts have been undertaken to have highlight factors associated with their engagement of health-related research. An exploratory study of factors presumed to be associated with participation in health-related research was conducted among a nonprobability sample of African Americans (n = 212) from a large urban community in the Midwest. The study was guided by a framework that hypothesized the influence of knowledge, beliefs, and perceptions about genetics and the involvement of providers in decision-making on willingness to participate in health-related genetic research. The results revealed that knowledge, beliefs, and perceptions about genetics and the involvement of providers were associated with willingness to engage in health-related genetic research (P < .05). The most interesting, however, was that 88.7% of the participants who had not previously been involved in a health-related study who expressed a willingness to participate reported that they “had never been asked.” Study findings suggest the need for research that further examines factors associated with the involvement of African Americans in health-related genetic research. PMID:24369499

Millon Underwood, Sandra; Buseh, Aaron G.; Kelber, Sheryl T.; Stevens, Patricia E.; Townsend, Leolia



Assessing the Health Needs of Chinese Older Adults: Findings from a Community-Based Participatory Research Study in Chicago's Chinatown.  


The objective of this study is to examine the cultural views of healthy aging, knowledge and barriers to services, and perception of health sciences research among community-dwelling Chinese older adults in Chicago's Chinatown. This qualitative study is guided by the Precede-Proceed conceptual model with community-based participatory research design. Data analysis is based on eight focus group interviews with Chinese older (age 60+) adults (n = 78). We used a grounded theory framework to systematically guide the thematic structure of our data. Findings show participants described cultural conception of health in terms of physical function, psychological well-being, social support, and cognitive function. The availability, affordability, and cultural barriers towards health care services were major negative enabling factors that inhibit participants from fulfilling health needs. Perception and knowledge of health sciences research were also discussed. This study has implications for the delivery of culturally appropriate health care services to the Chinese aging population. PMID:21253522

Dong, Xinqi; Chang, E-Shien; Wong, Esther; Wong, Bernarda; Skarupski, Kimberly A; Simon, Melissa A



Identifying Trustworthy Experts: How Do Policymakers Find and Assess Public Health Researchers Worth Consulting or Collaborating With?  

PubMed Central

This paper reports data from semi-structured interviews on how 26 Australian civil servants, ministers and ministerial advisors find and evaluate researchers with whom they wish to consult or collaborate. Policymakers valued researchers who had credibility across the three attributes seen as contributing to trustworthiness: competence (an exemplary academic reputation complemented by pragmatism, understanding of government processes, and effective collaboration and communication skills); integrity (independence, “authenticity”, and faithful reporting of research); and benevolence (commitment to the policy reform agenda). The emphases given to these assessment criteria appeared to be shaped in part by policymakers' roles and the type and phase of policy development in which they were engaged. Policymakers are encouraged to reassess their methods for engaging researchers and to maximise information flow and support in these relationships. Researchers who wish to influence policy are advised to develop relationships across the policy community, but also to engage in other complementary strategies for promoting research-informed policy, including the strategic use of mass media. PMID:22403693

Haynes, Abby S.; Derrick, Gemma E.; Redman, Sally; Hall, Wayne D.; Gillespie, James A.; Chapman, Simon; Sturk, Heidi



The Inter-Life Project: Researching the Potential of Art, Design and Virtual Worlds as a Vehicle for Assisting Young People with Key Life Changes and Transitions  

ERIC Educational Resources Information Center

Careers work in the twenty-first century faces a key challenge in terms of digital technologies: to evaluate their potential for careers work in challenging settings. Given the rapidity of developments, technologies require evaluation in research innovations and naturalistic settings. Virtual worlds offer potential for careers and guidance work,…

Lally, Victor; Sclater, Madeleine



Proceedings of Student-Faculty Research Day, CSIS, Pace University, May 3rd Developing a Quantum Key Distribution Simulator  

E-print Network

intercepted) cannot be overstated. Over the years, there has been an ongoing cat- and-mouse game between those of public keys. Both rely on the fact that there is not adequate computational power for someone to crack

Tappert, Charles


"The role of oxytocin in psychiatric disorders: A review of biological and therapeutic research findings"  

PubMed Central

Oxytocin is a peptide hormone integral in parturition, milk let-down, and maternal behaviors that has been demonstrated in animal studies to be important in the formation of pair bonds and in social behaviors. This hormone is increasingly recognized as an important regulator of human social behaviors, including social decision making, evaluating and responding to social stimuli, mediating social interactions, and forming social memories. In addition, oxytocin is intricately involved in a broad array of neuropsychiatric functions, and may be a common factor important in multiple psychiatric disorders such as autism, schizophrenia, mood and anxiety disorders. This review article examines the extant literature on the evidence for oxytocin dysfunction in a variety of psychiatric disorders and highlights the need for further research to understand the complex role of the oxytocin system in psychiatric disease to pave the way for developing new therapeutic modalities. Articles were selected that involved human participants with various psychiatric disorders, either comparing oxytocin biology to healthy controls or examining the effects of exogenous oxytocin administration. PMID:24651556

Cochran, David; Fallon, Daniel; Hill, Michael; Frazier, Jean A.



X. Conclusions: overview of findings from the era study, inferences, and research implications.  


In this monograph, we have brought the findings of the English and Romanian Adoptee (ERA) study up to age 15 years and, in so doing, have focused especially on the question of whether there are deprivation-specific psychological patterns (DSPs) that differ meaningfully from other forms of psychopathology. For this purpose, our main analytic strategy was to compare the subgroup of young people who had received institutional care in Romania that persisted up to at least the age of 6 months and a pooled comparison group that comprised the remainder of the sample. In chapter II, we presented the evidence that there were no significant variations among the three subgroups that made up the pooled comparison group. A large proportion of this pooled comparison group came from the 52 individuals adopted before the age of 6 months from within the United Kingdom, who had not experienced institutional care or other major deprivation experiences. In addition, there were 45 children who had experienced institutional care that had ceased before the age of 6 months. Finally, there was a small group of 21 Romanian individuals who had come from a severely deprived background but who had not experienced institutional care. In the young people who experienced institutional deprivation, we found that a cut-off at 6 months marked the division between those without appreciable sequelae and those with a substantial proportion of persisting deficits. Because we found that the rate of deficits in the group who had experienced institutional care for 46 months did not vary according to the duration of institutional care, we pooled the entire group of individuals experiencing institutional care up to at least the age of 6 months. We found that these two pooled groups differed substantially and significantly in the rate of maladaptive outcomes. The details of the evidence justifying this pooling and a two-way comparison are provided in chapter II. Because of our interest in exploring the possibility of DSPs, our main subdivision within the above 6-month group was between those individuals showing the putative DSPs and those showing other forms of psychopathology or not showing deficits at all. PMID:20500640

Rutter, Michael; Sonuga-Barke, Edmund J



Do Students Eventually Get to Publish their Research Findings? The Case of Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Research in Cameroon  

PubMed Central

Background: Scientific publication is commonly used to communicate research findings and in most academic/research settings, to evaluate the potential of a researcher and for recruitment and promotion. It has also been said that researchers have the duty to make public, the findings of their research. As a result, researchers are encouraged to share their research findings with the scientific world through peer review publications. In this study, we looked at the characteristics and publication rate of theses that documented studies on human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome in Cameroon. Materials and Methods: To check if a thesis resulted in a publication, we searched: A database of publications on HIV in Cameroon, African Journals Online, PubMed and Google scholar. For each publication we recorded if the student was an author, the position of the student in the author listing, the journal and where the journal was indexed. We also looked at the impact factor of the journals. Results: One hundred and thirty theses/dissertations were included in the study, 74.6% (97/130) were written as part of a medical degree (MD), 23.8% (31/130) a postgraduate (PG) degree and 1.5% (2/130) for a Doctorate/PhD. On a whole, 13.9% (18/130) of the theses resulted in at least one publication in a scientific journal with a total of 22 journal articles, giving a mean publication rate of 0.17 article/thesis, 86.4% (11/22) were indexed on PubMed, 9.1% (2/22) on African Journals Online and 4.6% (1/22) on Google scholar. One PG thesis led to two book chapters. The student was the first author in 22.7% (5/22) of the articles and not an author in 9.1% (2/22) of the articles. Student supervisor was an author in all the articles. Conclusion: This study reveals that most students in Cameroon failed to transform their theses/dissertations to scientific publications. This indicates an urgent need to sensitize students on the importance of presenting their research findings in scientific meetings and peer reviewed journals. There is also a great necessity to build capacity in scientific writing among university students in Cameroon. PMID:24971222

Munung, NS; Vidal, L; Ouwe-Missi-Oukem-Boyer, O



DCCPS: BRP: HCIRB: Key Initiatives

Skip Navigation Twitter Multimedia Home About Key Initiatives Funding Resources Tools Cancer Control & Population Sciences Home Behavioral Research Program Home Health Communication and Informatics Research Branch Key Initiatives Centers of Excellence


St Jude researchers find that cancer diagnosis doesn’t increase a child’s risk of post-traumatic stress disorder

St. Jude Children’s Research Hospital study suggests previous research overestimated PTSD in young cancer patients; new findings highlight the ability of children to adjust and even thrive in response to challenges.


Increasing Capacity for Stewardship of Oceans and Coasts: Findings of the National Research Council Report  

NASA Astrophysics Data System (ADS)

With the increasing stress on ocean and coastal resources, ocean resource management will require greater capacity in terms of people, institutions, technology and tools. Successful capacity-building efforts address the needs of a specific locale or region and include plans to maintain and expand capacity after the project ends. In 2008, the US National Research Council published a report that assesses past and current capacity-building efforts to identify barriers to effective management of coastal and marine resources. The report recommends ways that governments and organizations can strengthen marine conservation and management capacity. Capacity building programs instill the tools, knowledge, skills, and attitudes that address: ecosystem function and change; processes of governance that influence societal and ecosystem change; and assembling and managing interdisciplinary teams. Programs require efforts beyond traditional sector-by-sector planning because marine ecosystems range from the open ocean to coastal waters and land use practices. Collaboration among sectors, scaling from local community-based management to international ocean policies, and ranging from inland to offshore areas, will be required to establish coordinated and efficient governance of ocean and coastal ecosystems. Barriers Most capacity building activities have been initiated to address particular issues such as overfishing or coral reef degradation, or they target a particular region or country facing threats to their marine resources. This fragmentation inhibits the sharing of information and experience and makes it more difficult to design and implement management approaches at appropriate scales. Additional barriers that have limited the effectiveness of capacity building programs include: lack of an adequate needs assessment prior to program design and implementation; exclusion of targeted populations in decision- making efforts; mismanagement, corruption, or both; incomplete or inappropriate evaluation procedures; and, lack of a coordinated and strategic approach among donors. A New Framework Improving ocean stewardship and ending the fragmentation of current capacity building programs will require a new, broadly adopted framework for capacity building that emphasizes cooperation, sustainability, and knowledge transfer within and among communities. The report identifies four specific features of capacity building that would increase the effectiveness and efficiency of future programs: 1. Regional action plans based on periodic program assessments to guide investments in capacity and set realistic milestones and performance measures. 2. Long-term support to establish self-sustaining programs. Sustained capacity building programs require a diversity of sources and coordinated investments from local, regional, and international donors. 3. Development of leadership and political will. One of the most commonly cited reasons for failure and lack of progress in ocean and coastal governance initiatives is lack of political will. One strategy for strengthening support is to identify, develop, mentor, and reward leaders. 4. Establishment of networks and mechanisms for regional collaboration. Networks bring together those working in the same or similar ecosystems with comparable management or governance challenges to share information, pool resources, and learn from one another. The report also recommends the establishment of regional centers to encourage and support collaboration among neighboring countries.

Roberts, S. J.; Feeley, M. H.



Finding potentially new multimorbidity patterns of psychiatric and somatic diseases: exploring the use of literature-based discovery in primary care research  

PubMed Central

Background Multimorbidity, the co-occurrence of two or more chronic medical conditions within a single individual, is increasingly becoming part of daily care of general medical practice. Literature-based discovery may help to investigate the patterns of multimorbidity and to integrate medical knowledge for improving healthcare delivery for individuals with co-occurring chronic conditions. Objective To explore the usefulness of literature-based discovery in primary care research through the key-case of finding associations between psychiatric and somatic diseases relevant to general practice in a large biomedical literature database (Medline). Methods By using literature based discovery for matching disease profiles as vectors in a high-dimensional associative concept space, co-occurrences of a broad spectrum of chronic medical conditions were matched for their potential in biomedicine. An experimental setting was chosen in parallel with expert evaluations and expert meetings to assess performance and to generate targets for integrating literature-based discovery in multidisciplinary medical research of psychiatric and somatic disease associations. Results Through stepwise reductions a reference set of 21?945 disease combinations was generated, from which a set of 166 combinations between psychiatric and somatic diseases was selected and assessed by text mining and expert evaluation. Conclusions Literature-based discovery tools generate specific patterns of associations between psychiatric and somatic diseases: one subset was appraised as promising for further research; the other subset surprised the experts, leading to intricate discussions and further eliciting of frameworks of biomedical knowledge. These frameworks enable us to specify targets for further developing and integrating literature-based discovery in multidisciplinary research of general practice, psychology and psychiatry, and epidemiology. PMID:23775174

Vos, Rein; Aarts, Sil; van Mulligen, Erik; Metsemakers, Job; van Boxtel, Martin P; Verhey, Frans; van den Akker, Marjan



Managing misaligned paternity findings in research including sickle cell disease screening in Kenya: ‘Consulting communities’ to inform policy?  

PubMed Central

The management of misaligned paternity findings raises important controversy worldwide. It has mainly, however, been discussed in the context of high-income countries. Genetic and genomics research, with the potential to show misaligned paternity, are becoming increasingly common in Africa. During a genomics study in Kenya, a dilemma arose over testing and sharing information on paternal sickle cell disease status. This dilemma may be paradigmatic of challenges in sharing misaligned paternity findings in many research and health care settings. Using a deliberative approach to community consultation to inform research practice, we explored residents' views on paternal testing and sharing misaligned paternity information. Between December 2009 and November 2010, 63 residents in Kilifi County were engaged in informed deliberative small group discussions, structured to support normative reflection within the groups, with purposive selection to explore diversity. Analysis was based on a modified framework analysis approach, drawing on relevant social science and bioethics literature. The methods generated in-depth individual and group reflection on morally important issues and uncovered wide diversity in views and values. Fundamental and conflicting values emerged around the importance of family interests and openness, underpinned by disagreement on the moral implications of marital infidelity and withholding truth. Wider consideration of ethical issues emerging in these debates supports locally-held reasoning that paternal sickle cell testing should not be undertaken in this context, in contrast to views that testing should be done with or without the disclosure of misaligned paternity information. The findings highlight the importance of facilitating wider testing of family members of affected children, contingent on the development and implementation of national policies for the management of this inherited disorder. Their richness also illustrates the potential for the approach adopted in this study to strengthen community consultation. PMID:24034967

Marsh, Vicki; Kombe, Francis; Fitzpatrick, Ray; Molyneux, Sassy; Parker, Michael




E-print Network

Receptor Subunits in the Ventral Tegmental Area Enhances Motivation for Cocaine Chronic cocaine use produces numerous biological changes in brain, but relatively few are functionally associated with cocaine reinforcement. Here the authors show that daily intravenous cocaine self-administration, but not passive cocaine

Bandettini, Peter A.


Concordance between Clinical Practice and Published Evidence: Findings from The National Dental Practice-Based Research Network  

PubMed Central

Background. Documenting the gap between what is occurring in clinical practice and what published research suggests is an important step toward improving care. This study quantified concordance between clinical practice and published evidence across preventive, diagnostic and treatment procedures among a sample of dentists in the National Dental Practice-Based Research Network. Methods. Network dentists completed one questionnaire about their demographic characteristics and another about how they treat patients across 12 scenarios/clinical practice behaviors. Responses to each clinical practice were coded as consistent (i.e., ‘1’) or inconsistent (i.e., ‘0’) with published evidence, summed, and divided by the number of all non-missing to create an overall ‘concordance’ score, calculated as the mean percent of responses that were consistent with published evidence. Results. Analyses were limited to participants in the United States (N = 591). Mean concordance at the practitioner level was 62% (SD = 18); procedure-specific concordance ranged from 8-100%. Affiliation with a large group practice, being a female practitioner, and receiving a dental degree before 1990 were independently associated with high concordance (?75%). Conclusions. Dentists reported a medium-range concordance between practice and evidence. Clinical Implications. Efforts to bring research findings into routine practice are needed. PMID:24379327

Norton, Wynne E.; Funkhouser, Ellen; Makhija, Sonia K.; Gordan, Valeria V.; Bader, James D.; Rindal, D. Brad; Pihlstrom, Daniel J.; Hilton, Thomas J.; Frantsve-Hawley, Julie; Gilbert, Gregg H.



Translational nutrition research at UC-Davis – the key role of the clinical and translational science center  

Technology Transfer Automated Retrieval System (TEKTRAN)

To better understand the facility and equipment needs for human clinical nutrition research the New York Academy of Sciences presented a symposium. This paper is the result of that symposium and provides information into how clinical nutrition research is conducted at the Clinical and Translational ...


Embedding Undergraduate Research Experiences within the Curriculum: A Cross-Disciplinary Study of the Key Characteristics Guiding Implementation  

ERIC Educational Resources Information Center

Undergraduate research experiences provide students with opportunities to engage in high-impact experiential learning. Although prevalent in the sciences, there are now extensive banks of case studies demonstrating the use of undergraduate research as an educationally enriching activity across many disciplines. This study investigated the…

Zimbardi, Kirsten; Myatt, Paula



Finding Canadian Government Pubs.  

E-print Network

Finding Canadian Government Pubs. Econ 773 Peggy Findlay Reference Librarian Mills Research Help 2 Objectives Finding print Canadian government publications Electronic Canadian government publications Census Information/ Survey Data #12;Finding Canadian Documents ­ Econ 773 Finding Print Canadian Government

Haykin, Simon


Health effects of tropospheric ozone: review of recent research findings and their implications to ambient air quality standards.  


The U.S. Environmental Protection Agency (EPA) Administrator proposed (on August 3, 1992) to retain the current National Ambient Air Quality Standard (NAAQS) for ozone (O3) on the basis of data assembled in a draft Criteria Document (1986) and its Addendum (1988) which, together with a draft Staff Paper (1988), received public comment and review comments by the EPA's Clean Air Scientific Advisory Committee (CASAC). This paper summarizes and discusses research findings presented since 1988 which, based on the author's experience as a Chairman of CASAC, are most relevant to the promulgation of a primary (health based) NAAQS for O3. These newer findings include substantial evidence from controlled chamber exposure studies and field studies in natural settings that the current NAAQS contains no margin of safety against short-term effects that the EPA has considered to be adverse. They also include evidence from epidemiologic studies that current ambient exposures are associated with reduced baseline lung function, exacerbation of asthma and premature mortality, as well as evidence from chronic animal exposure studies at concentrations within current ambient peak levels that indicate progressive and persistent lung function and structural abnormalities. The current NAAQS, if retained, may therefore also be inadequate to protect the public from effects resulting from chronic exposure to O3. PMID:8518544

Lippmann, M



Operator's Training Checklist for those Conducting Human Research at the CMRR The purpose of this document is to provide a list of key tasks that operators of the human research  

E-print Network

) Safely landmarking of subject using the laser system Adjusting light, airflow, and sound volume system. Use of SAR monitoring system Adjusting RF power RF limits and connections for coils to be used of this document is to provide a list of key tasks that operators of the human research systems will need to know

Thomas, David D.


2003 Veblen, T.T. Key issues in fire regime research for fuels management and ecological restoration. Pages 259-276 in: P. Omi and L. Joyce (technical eds). Fire,  

E-print Network

2003 Veblen, T.T. Key issues in fire regime research for fuels management and ecological restoration. Pages 259-276 in: P. Omi and L. Joyce (technical eds). Fire, Fuel Treatments and Ecological, Forest Service, Rocky Mountain Research Station. 475 p. AN INTRODUCTION TO KEY ISSUES IN FIRE REGIME

Veblen, Thomas T.


Key Facts

Key Facts Scientists know that: I-131 breaks down rapidly in the atmosphere and environment Exposure was highest in the first few days after each nuclear test explosion Most exposure occurred through drinking fresh milk People received little exposure


Interventions for children with fetal alcohol spectrum disorders (FASDs): overview of findings for five innovative research projects.  


It is well established that prenatal exposure to alcohol causes damage to the developing fetus, resulting in a spectrum of disorders known as fetal alcohol spectrum disorders (FASDs). Although our understanding of the deficits and disturbances associated with FASDs is far from complete, there are consistent findings indicating these are serious, lifelong disabilities-especially when these disabilities result from central nervous system damage. Until recently, information and strategies for interventions specific to individuals with FASDs have been gleaned from interventions used with people with other disabilities and from the practical wisdom gained by parents and clinicians through trial and error or shared through informal networks. Although informative to a limited degree, such interventions have been implemented without being evaluated systematically or scientifically. The purpose of this article is to provide a brief overview of a general intervention framework developed for individuals with FASDs and the methods and general findings of five specific intervention research studies conducted within this framework. The studies evaluated five different interventions in five diverse locations in the United States, with different segments of the FASD population. Nonetheless, all participants showed improvement in the target behaviors or skills, with four studies achieving statistical significance in treatment outcomes. Important lessons emerged from these five interventions that may explain success: including parent education or training, teaching children specific skills they would usually learn by observation or abstraction, and integration into existing systems of treatment. A major implication of these research studies for families dealing with FASDs is that there are now interventions available that can address their children's needs and that can be presented as scientifically validated and efficacious to intervention agents such as schools, social services, and mental health providers. In the field of FASD research and clinical service, a common theme reported by families has been that clinicians and professionals have been reluctant to diagnose their children because there were no known effective treatments. Results of these five studies dispel that concern by demonstrating several interventions that have been shown to improve the lives of individuals with FASDs and their families. PMID:19327965

Bertrand, Jacquelyn



[Key issues in researching spirituality and religiosity in the light of the ASPIRES instrument (Assessment of Spirituality and Religious Sentiments) Developed by Ralph Piedmont].  


Our article reviews the major questions raised by the psychological research of spirituality and religion, as well as the historical background of this research area. In our view the scientific exploration of spirituality and religion constitutes a process that allows for both empirical and hermeneutical approaches and as such it is open for a dialogue with other branches of social sciences. The most important topics addressed by the article include: 1. possible conceptualizations of the terms spirituality and religion; the connection between the two; similarities and differences; 2. the interpretation of spirituality as a dimension of the personality; 3. the question of measurement of spirituality and tools of its measurement; 4. the effects of spirituality; and 5. the culture relatedness of research data. Finally we demonstrate how the ASPIRES scale recently developed by R. Piedmont, its theoretical approach, development process, and empirical results try to answer these key questions. PMID:20660944

Tomcsányi, Teodóra; Ittzés, András; Horváth-Szabó, Katalin; Martos, Tamás; Szabó, Tünde



Making a Bigger Deal of the Smaller Words: Function Words and Other Key Items in Research Writing by Chinese Learners  

ERIC Educational Resources Information Center

In many mainland Chinese universities, undergraduate students specializing in English language and applied linguistics are required to write a dissertation, in English, of about 5000 words exploring some aspect of original research. This is a task which is of considerable difficulty not only at the genre or discourse level but also at the…

Lee, David Y. W.; Chen, Sylvia Xiao



Key Considerations for the Success of Medical Education Research and Innovation Units in Canada: Unit Director Perceptions  

ERIC Educational Resources Information Center

Growth in the field of medical education is evidenced by the proliferation of units dedicated to advancing Medical Education Research and Innovation (MERI). While a review of the literature discovered narrative accounts of MERI unit development, we found no systematic examinations of the dimensions of and structures that facilitate the success of…

Varpio, Lara; Bidlake, Erin; Humphrey-Murto, Sue; Sutherland, Stephanie; Hamstra, Stanley J.



If you cannot find what you are looking for quickly, please contact Research Liaison Officer Steve Penny 0780 890 0331  

E-print Network

­ Steve Penny 0780 890 0331 Key web links: Research Update 17th November, events, publications, newletters etc. can be found through the FR website: www.forestry pages. 2. Register for the FR newsletter: 3. Register for events


Research on Key Factors and Their Interaction Effects of Electromagnetic Force of High-Speed Solenoid Valve  

PubMed Central

Analysis consisting of numerical simulations along with lab experiments of interaction effects between key parameters on the electromagnetic force based on response surface methodology (RSM) has been also proposed to optimize the design of high-speed solenoid valve (HSV) and improve its performance. Numerical simulation model of HSV has been developed in Ansoft Maxwell environment and its accuracy has been validated through lab experiments. Effect of change of core structure, coil structure, armature structure, working air gap, and drive current on the electromagnetic force of HSV has been analyzed through simulation model and influence rules of various parameters on the electromagnetic force have been established. The response surface model of the electromagnetic force has been utilized to analyze the interaction effect between major parameters. It has been concluded that six interaction factors including working air gap with armature radius, drive current with armature thickness, coil turns with side pole radius, armature thickness with its radius, armature thickness with side pole radius, and armature radius with side pole radius have significant influence on the electromagnetic force. Optimal match values between coil turns and side pole radius; armature thickness and side pole radius; and armature radius and side pole radius have also been determined. PMID:25243217

Fan, Liyun; Xu, De; Ma, Xiuzhen; Song, Enzhe



Gender Research in the National Institute on Drug Abuse National Treatment Clinical Trials Network: A Summary of Findings  

PubMed Central

Background The NIDA National Drug Abuse Treatment Clinical Trials Network (CTN) was established to foster translation of research into practice in substance abuse treatment settings. The CTN provides a unique opportunity to examine in multi-site, translational clinical trials, the outcomes of treatment interventions targeting vulnerable sub-groups of women; the comparative effectiveness of gender-specific protocols to reduce risk behaviors; and gender differences in clinical outcomes. Objectives To review gender-related findings from published CTN clinical trials and related studies from January, 2000 through March, 2010. Methods CTN studies were selected for review if they focused on treatment outcomes or services for special populations of women with substance use disorders (SUDs) including those with trauma histories, pregnancy, co-occurring eating and other psychiatric disorders and HIV risk behaviors; or implemented gender-specific protocols. Results The CTN has randomized 11,500 participants (41% women) across 200 clinics in 24 randomized clinical trials in community settings, of which 4 have been gender-specific. This paper summarizes gender-related findings from CTN clinical trials and related studies, focusing on trauma histories, pregnancy, co-occurring eating and other psychiatric disorders, and HIV risk behaviors. Conclusions These published studies have expanded the evidence base regarding interventions for vulnerable groups of women with SUDs as well as gender-specific interventions to reduce HIV risk behaviors in substance using men and women. The results also underscore the complexity of accounting for gender in the design of clinical trials and analysis of results. Scientific Relevance To fully understand the relevance of gender-specific moderators and mediators of outcome, it is essential that future translational studies adopt more sophisticated approaches to understanding and measuring gender-relevant factors and plan sample sizes that are adequate to support more nuanced analytic methods. PMID:21854272

Greenfield, Shelly F.; Rosa, Carmen; Putnins, Susan I.; Green, Carla A.; Brooks, Audrey J.; Calsyn, Donald A.; Cohen, Lisa R.; Erickson, Sarah; Gordon, Susan M.; Haynes, Louise; Killeen, Therese; Miele, Gloria; Tross, Susan; Winhusen, Theresa



A study of the influence of a researched-based rationale on science teachers' beliefs and practices across key stages of teacher development  

NASA Astrophysics Data System (ADS)

Recent reforms in science education have shifted their attention towards teacher education. Although studies have been conducted to investigate science teacher education programs in the United States, few studies have explored the way in which teacher education programs can be used to support beginning science teachers as they progress from their formal teacher preparation into the early years of their career. Many educators have proposed that although learning to teach takes place along a continuum of professional development experiences and programs, extraneous factors existing within school communities minimize the impact of science teacher preparation programs. This study has three purposes: the exploration of science teachers' current teaching beliefs and practices at key stages of the teacher development continuum; the determination of how these beliefs and practices have evolved over time since their formal teacher preparation; and an investigation of the influence of a research-based rationale for teaching science on teachers' beliefs and practices across key stages of the teacher development continuum. The research participants involved in this qualitative research study consisted of twelve individuals divided equally into three cohorts that represent key stages of the science teacher development continuum. Throughout the study, the participants were interviewed regarding their teaching beliefs and practices and observed teaching science lessons in an effort to determine what influence, if any, the research-based rationale has on science teachers at varying stages of their teaching career. This study contributes to the growing literature on how to adequately prepare and support science teachers at all stages of development. The outcomes of this study suggest that although the research-based rationale experience was perceived as a strongly influential experience impacting teachers' pedagogical beliefs and practices, the actual teaching practices are not consistent with teachers' proposed beliefs. Several social and cultural factors were reported as having an influence on classroom behaviors. The results yielded from this study call for further research investigations to be conducted on how to best implement professional development experiences during preservice teacher education programs that will have lasting impacts throughout teachers' careers.

Diana, Thomas Joseph, Jr.


Key Literature.  

ERIC Educational Resources Information Center

Provides an annotated bibliography of the literature considered by the contributing authors to this journal issue to be of key importance to the subjects covered in their articles. These subjects include: transfer, vocational education, remedial education, English as a second language (ESL), assessment, student services, faculty and professional…

New Directions for Community Colleges, 2002



Key distributionKey distribution Key distribution, symmetric encryption  

E-print Network

COMP 522 Key distributionKey distribution COMP 522 Key distribution, symmetric encryption From in a secure way and must keep the key secure" · Important issue: how to distribute secret keys? COMP 522 Key distribution, manual delivery For two parties A and B: · A key could be created by A and delivered physically

Fisher, Michael


Factors influencing the utilization of research findings by health policy-makers in a developing country: the selection of Mali's essential medicines  

PubMed Central

Background Research findings are increasingly being recognized as an important input in the formation of health policy. There is concern that research findings are not being utilized by health policy-makers to the extent that they could be. The factors influencing the utilization of various types of research by health policy-makers are beginning to emerge in the literature, however there is still little known about these factors in developing countries. The object of this study was to explore these factors by examining the policy-making process for a pharmaceutical policy common in developing countries; an essential medicines list. Methods A study of the selection and updating of Mali's national essential medicines list was undertaken using qualitative methods. In-depth semi-structured interviews and a natural group discussion were held with national policy-makers, most specifically members of the national commission that selects and updates the country's list. The resulting text was analyzed using a phenomenological approach. A document analysis was also performed. Results Several factors emerged from the textual data that appear to be influencing the utilization of health research findings for these policy-makers. These factors include: access to information, relevance of the research, use of research perceived as a time consuming process, trust in the research, authority of those who presented their view, competency in research methods, priority of research in the policy process, and accountability. Conclusion Improving the transfer of research to policy will require effort on the part of researchers, policy-makers, and third parties. This will include: collaboration between researchers and policy-makers, increased production and dissemination of relevant and useful research, and continued and improved technical support from networks and multi-national organizations. Policy-makers from developing countries will then be better equipped to make informed decisions concerning their health policy issues. PMID:17338810

Albert, Michael A; Fretheim, Atle; Maïga, Diadié



DCCPS: BRP: TCRB: Key Initiatives

Twitter Multimedia Home About Key Initiatives Funding Resources Tools Cancer Control & Population Sciences Home Behavioral Research Program Home Tobacco Control Research Branch American Stop Smoking Intervention Study (ASSIST) NCI Tobacco Control Monograph


Ambient Particulate Matter during MILAGRO in Mexico City: Main Findings, Impacts (on AQ and Climate), and Future Research Needs  

NASA Astrophysics Data System (ADS)

The MILAGRO campaign was a large international field experiments conduced in Mexico City and Central Mexico during March 2006. We present an overview of the main findings related to particulate matter and aerosol radiative properties. PM levels inside Mexico City were similar or higher than those in the most polluted North American cities, but ~5 times lower than levels in the most polluted Asian megacities During the study, PM10 and PM2.5 concentrations in the urban area of were about double the concentrations in the rural areas surrounding Mexico City. PM2.5 made up about half of the PM10 concentrations, with small amounts of mass in the PM2.5-PM1.0 range. Mineral matter made up approximately 25% of the PM10 and on average 15% and 28% of the PM2.5 in the urban and rural areas, respectively. Approximately 25% of the PM2.5 was secondary inorganic ions with the remaining PM2.5 mass being comprised of largely carbonaceous aerosol. Except for surface measurements at the central sampling sites in Mexico city, the elemental carbon mass absorption efficiency was relatively constant for aircraft and surface measurements throughout the study, contrary to expectations. Although different organic aerosol (OA) source apportionment methods had some differences, there was agreement that the dominant sources of carbonaceous aerosol were secondary OA (SOA), biomass burning, and mobile sources. The impact of biomass burning to the aerosol outflow from the region was much larger than to the surface concentrations inside the city. SOA formation from primary semivolatile and intermediate volatility precursors has the potential to close the gap in predicted vs. measured SOA, while formation from glyoxal also makes an important contribution, especially to organic oxygen. Biogenic SOA advected from the coastal mountain ranges contributes about 1 ?g m-3 to concentrations in the MCMA. Primary OA from anthropogenic and biomass burning sources was found to be semivolatile, while secondary OA was less volatile than POA and aged SOA was essentially non-volatile, in contradiction with current models. Growth rates of new particle formation in Mexico City was very large and found to be impacted by nitrogen containing organic compounds, organic acids, and hydroxyl organic acids, with only a smaller fraction of sulfate aerosol. Some open research questions include the following: additional work is needed to fully quantify the sources of substantial (30-45%) modern carbon in organic aerosols during low biomass burning periods. Discrepancies between the two modern carbon datasets deserve further study. The impact of regional dust vs. road resuspension, as well as heterogeneous reactions of HNO3 with dust need to be quantified. The impact of some POA sources such as food cooking, biofuel use, and open trash burning may be important, but remains poorly characterized. Some differences in the apportionment of biomass burning PM between different approaches were observed and need further research, as these techniques together represent the state of the art for source apportionment. Anthropogenic SOA predictions are improving in terms of magnitude but are poorly constrained by the data. More specific precursor, intermediate, and tracer measurements are needed in future campaigns. SOA from biomass burning sources, although not dominant in the city, remains poorly characterized and appears to be underpredicted by traditional models.

Jimenez, Jose-Luis; Schauer, James J.; Molina, Luisa T.; MILAGRO Pm Team



Development of photoelectric pulse laser range finding system  

Microsoft Academic Search

The important development trend of laser pulse range finding system is to improve precision and realize miniaturization. This thesis researches laser pulse range finding system and analyses the key technique on the working principle and the time measurement accuracy. Based on the analyses and compared with several existent timing methods, the method of combining traditional counting method with time linear

Boxue Tan; Shuyun Wang; Tianze Li; Fang Wen



Phage-Finding Using Mycobacteria: A Secondary School or Undergraduate Research Module with the Potential to Gain Scientific Authorship  

ERIC Educational Resources Information Center

Mycobacteriophages are in the limelight of biomedical science (Pedulla et al., 2003), and new phage can be discovered and studied in a variety of high school and undergraduate educational settings. Simple methods for finding and studying new mycobacteriophage are described.

Schwebach, James Reid; Jacobs, William R., Jr.



Overview of research on finding semantic meanings from low-level features in content-based image retrieval  

Microsoft Academic Search

Content-based image retrieval is a bottleneck of research in multimedia systems. The research has proved extremely difficult because of the inherent problems in proper automated analysis and feature extraction of the image to facilitate proper classification of various objects. An image may contain more than one objects and to segment the image in line with object features to extract meaningful

Sagarmay Deb



Critical Thinking: A Statement of Expert Consensus for Purposes of Educational Assessment and Instruction. Research Findings and Recommendations.  

ERIC Educational Resources Information Center

Using a qualitative research methodology, known as the Delphi Method, an interactive panel of experts was convened to work toward a consensus on the role of critical thinking (CT) in educational assessment and instruction. In Delphi research, experts participate in several rounds of questions that require thoughtful and detailed responses.…

Facione, Peter A.


St. Jude researchers find a childhood eye tumor is made up of hybrid cells with jumbled development:

A research team led by St. Jude Children’s Research Hospital scientists has identified a potential new target for treatment of the childhood eye tumor retinoblastoma. Their work also settles a scientific debate by showing the cancer’s cellular origins are as scrambled as the developmental pathways at work in the tumor.


Women in Science Award Winners Women scientists at the Medical College of Wisconsin are advancing biomedical research and finding innovative  

E-print Network

Women in Science Award Winners Women scientists at the Medical College of Wisconsin are advancing care. The College celebrates their accomplishments with the Women Pioneers in Research Award. 2007 in the Department of Medicine. She is researching the role of fatty acids in the body and the affect these acids


Grants Management Office Guide: How Do I Find Grant Funding? GMO Guide: How Do I Find Grant Funding?  

E-print Network

Grants Management Office Guide: How Do I Find Grant Funding? 1 GMO Guide: How Do I Find Grant Office (GMO) updates the Current Funding Opportunities Page as soon as information on schemes opening) are a significant source of funding for Australian researchers. The GMO tracks key dates for ARC and NHMRC major

New South Wales, University of


Integration of Research and Practice in Substance Use Disorder Treatment: Findings from Focus Groups of Clinicians, Researchers, Educators, Administrators, and Policy Makers  

ERIC Educational Resources Information Center

Clinicians, researchers, educators, administrators, and policy makers, who represented stakeholders in the substance abuse treatment field, participated in 5 focus groups. Four general areas regarding integration of research and practice were investigated: definition of research, training/education, current integration, and future integration.…

Campbell, Todd C.; Daood, Christopher; Catlin, Lynn; Abelson, Alissa



Consulting communities on feedback of genetic findings in international health research: sharing sickle cell disease and carrier information in coastal Kenya  

PubMed Central

Background International health research in malaria-endemic settings may include screening for sickle cell disease, given the relationship between this important genetic condition and resistance to malaria, generating questions about whether and how findings should be disclosed. The literature on disclosing genetic findings in the context of research highlights the role of community consultation in understanding and balancing ethically important issues from participants’ perspectives, including social forms of benefit and harm, and the influence of access to care. To inform research practice locally, and contribute to policy more widely, this study aimed to explore the views of local residents in Kilifi County in coastal Kenya on how researchers should manage study-generated information on sickle cell disease and carrier status. Methods Between June 2010 and July 2011, we consulted 62 purposively selected Kilifi residents on how researchers should manage study-generated sickle cell disease findings. Methods drew on a series of deliberative informed small group discussions. Data were analysed thematically, using charts, to describe participants’ perceptions of the importance of disclosing findings, including reasoning, difference and underlying values. Themes were derived from the underlying research questions and from issues emerging from discussions. Data interpretation drew on relevant areas of social science and bioethics literature. Results Perceived health and social benefits generated strong support for disclosing findings on sickle cell disease, but the balance of social benefits and harms was less clear for sickle cell trait. Many forms of health and social benefits and harms of information-sharing were identified, with important underlying values related to family interests and the importance of openness. The influence of micro and macro level contextual features and prioritization of values led to marked diversity of opinion. Conclusions The approach demonstrates a high ethical importance in many malaria endemic low-to-middle income country settings of disclosing sickle cell disease findings generated during research, alongside provision of effective care and locally-informed counselling. Since these services are central to the benefits of disclosure, health researchers whose studies include screening for sickle cell disease should actively promote the development of health policy and services for this condition in situations of unmet need, including through the prior development of collaborative partnerships with government health managers and providers. Community consultation can importantly enrich ethical debate on research practice where in-depth exploration of informed views and the potential for difference are taken into account. PMID:24125465



Who Has Used Internal Company Documents for Biomedical and Public Health Research and Where Did They Find Them?  

PubMed Central

Objective To describe the sources of internal company documents used in public health and healthcare research. Methods We searched PubMed and Embase for articles using internal company documents to address a research question about a health-related topic. Our primary interest was where authors obtained internal company documents for their research. We also extracted information on type of company, type of research question, type of internal documents, and funding source. Results Our searches identified 9,305 citations of which 357 were eligible. Scanning of reference lists and consultation with colleagues identified 4 additional articles, resulting in 361 included articles. Most articles examined internal tobacco company documents (325/361; 90%). Articles using documents from pharmaceutical companies (20/361; 6%) were the next most common. Tobacco articles used documents from repositories; pharmaceutical documents were from a range of sources. Most included articles relied upon internal company documents obtained through litigation (350/361; 97%). The research questions posed were primarily about company strategies to promote or position the company and its products (326/361; 90%). Most articles (346/361; 96%) used information from miscellaneous documents such as memos or letters, or from unspecified types of documents. When explicit information about study funding was provided (290/361 articles), the most common source was the US-based National Cancer Institute. We developed an alternative and more sensitive search targeted at identifying additional research articles using internal pharmaceutical company documents, but the search retrieved an impractical number of citations for review. Conclusions Internal company documents provide an excellent source of information on health topics (e.g., corporate behavior, study data) exemplified by articles based on tobacco industry documents. Pharmaceutical and other industry documents appear to have been less used for research, indicating a need for funding for this type of research and well-indexed and curated repositories to provide researchers with ready access to the documents. PMID:24800999

Wieland, L. Susan; Rutkow, Lainie; Vedula, S. Swaroop; Kaufmann, Christopher N.; Rosman, Lori M.; Twose, Claire; Mahendraratnam, Nirosha; Dickersin, Kay



Implementing the ten steps to successful breastfeeding in multiple hospitals serving low-wealth patients in the US: innovative research design and baseline findings  

PubMed Central

Background The Ten Steps to Successful Breastfeeding are maternity practices proven to support successful achievement of exclusive breastfeeding. They also are the basis for the WHO/UNICEF Baby-Friendly Hospital Initiative (BFHI). This study explores implementation of these steps in hospitals that serve predominantly low wealth populations. Methods A quasi-experimental design with mixed methods for data collection and analysis was included within an intervention project. We compared the impact of a modified Ten Steps implementation approach to a control group. The intervention was carried out in hospitals where: 1) BFHI designation was not necessarily under consideration, and 2) the majority of the patient population was low wealth, i.e., eligible for Medicaid. Hospitals in the research aspect of this project were systematically assigned to one of two groups: Initial Intervention or Initial Control/Later Intervention. This paper includes analyses from the baseline data collection, which consisted of an eSurvey (i.e., Carolina B-KAP), Maternity Practices in Infant Nutrition and Care survey tool (mPINC), the BFHI Self-Appraisal, key informant interviews, breastfeeding data, and formatted feedback discussion. Results Comparability was ensured by statistical and non-parametric tests of baseline characteristics of the two groups. Additional findings of interest included: 1) a universal lack of consistent breastfeeding records and statistics for regular monitoring/review, 2) widespread misinterpretation of associated terminology, 3) health care providers’ reported practices not necessarily reflective of their knowledge and attitudes, and 4) specific steps were found to be associated with hospital breastfeeding rates. A comprehensive set of facilitators and obstacles to initiation of the Ten Steps emerged, and hospital-specific practice change challenges were identified. Discussion This is one of the first studies to examine introduction of the Ten Steps in multiple hospitals with a control group and in hospitals that were not necessarily interested in BFHI designation, where the population served is predominantly low wealth, and with the use of a mixed methods approach. Limitations including numbers of hospitals and inability to adhere to all elements of the design are discussed. Conclusions For improvements in quality of care for breastfeeding dyads, innovative and site-specific intervention modification must be considered. PMID:23688264



Developing a Culture of Enquiry-Based, Independent Learning in a Research-Led Institution: Findings from a Survey of Pedagogic Practice  

ERIC Educational Resources Information Center

This paper reports select findings from an institutional survey designed to support long-term strategic developments at a research-led institution in the UK. These developments include a revised Learning and Teaching Strategy that has at its core the promotion of a "cross-institutional culture of enquiry-based, independent learning". The survey…

McLinden, Mike; Edwards, Corony



Everything in Its Place: Researchers Identify Brain Cells Used to Categorize Findings Shed Light on the Brain Processes Behind Learning and Memory  

E-print Network

Everything in Its Place: Researchers Identify Brain Cells Used to Categorize Images Findings Shed Light on the Brain Processes Behind Learning and Memory Boston, MA-August 27,2006-Socks in the sock in youth. But what parts of the brain are used to encode such categories as socks, shirts, or any other

Freedman, David J.


Home Practice Areas Jurisdictions Cases & Codes News CLE Market Center Research a Lawyer FindLaw | For Legal Professionals | For Corporate Counsel | For Law Students  

E-print Network

Home Practice Areas Jurisdictions Cases & Codes News CLE Market Center Research a Lawyer Find | Newsletters U.S. 4th Circuit Court of Appeals PEOPLE FOR ETHICAL v DOUGHNEY PUBLISHED UNITED STATES COURT OF APPEALS FOR THE FOURTH CIRCUIT PEOPLE FOR THE ETHICAL TREATMENT OF ANIMALS, Plaintiff-Appellee, v. No. 00

Shamos, Michael I.