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  1. Autosomal dominant rolandic epilepsy with speech dyspraxia.

    PubMed

    Scheffer, I E

    2000-01-01

    Autosomal Dominant Rolandic Epilepsy with Speech Dyspraxia (ADRESD) is a rare disorder which highlights the relationship between Benign Rolandic Epilepsy (BRE) and speech and language disorders. Subtle speech and language disorders have recently been well characterised in BRE. ADRESD is associated with long term, more severe speech and language difficulties. The time course of rolandic epilepsy in ADRESD is typical of that of BRE. ADRESD is inherited in an autosomal dominant manner with anticipation. It is postulated that the anticipation may be due to an, as yet unidentified, triplet repeat expansion in a gene for rolandic epilepsy. BRE follows complex inheritance but it is possible that ADRESD may hold some valuable clues to the pathogenesis of BRE. PMID:11231219

  2. Academic Performance in Children with Rolandic Epilepsy

    ERIC Educational Resources Information Center

    Piccinelli, P.; Borgatti, R.; Aldini, A.; Bindelli, D.; Ferri, M.; Perna, S.; Pitillo, G.; Termine, C.; Zambonin, F.; Balottin, U.

    2008-01-01

    The aim of this study was to investigate the frequency of reading, writing, and calculation disabilities in children with typical rolandic epilepsy (RE) and healthy control children. We also aimed to define the possible electroclinical markers of specific cognitive dysfunctions in RE. School abilities were evaluated and compared in 20 children…

  3. Obituary: Roland Svensson, 1950-2003

    NASA Astrophysics Data System (ADS)

    Björnsson, Claes-Ingvar

    2003-12-01

    Roland Svensson was found dead on 8 April 2003. He succumbed to the complications arising from diabetes. His contribution to the understanding of the basic properties of relativistic plasmas remains a cornerstone when studying radiation processes in many astrophysical contexts. Roland was born on 6 May 1950 in Karlshamn, Sweden. At a young age he moved with his family to Skåne, the southernmost part of Sweden. This is where he received his early education including a BS in Physics at the University of Lund in 1973. For the rest of his life, this region was home for Roland. His mother and father are Linnea Martinsson (d. 1984) and Sune Svensson. The two younger brothers are Lennart and Peter. Lennart works as a machine engineer in Sweden while Peter has settled in California as a biology professor. Roland started graduate studies in theoretical physics in Lund before receiving a Fulbright Scholarship in 1976. He then moved to the University of California in Santa Cruz and enrolled in the astronomy and astrophysics graduate program. Although his interest in astronomy had been raised during the time in Lund, it was the stimulating environment in Santa Cruz that convinced Roland to concentrate on research in astronomy. With Roland's attitude of never accepting anything unless he understood its roots, his extended background in physics served him well throughout his astronomy career; in particular, it influenced his choice of a thesis topic. At the time, the importance of relativistic temperatures attained by accreting matter in the immediate vicinity of neutron stars and black holes was becoming clear. Roland set out to make a detailed description of the physical effects electron-positron pair production and annihilation would have on such plasmas. In 1981 Roland defended his thesis titled ``Physical Properties in Relativistic Plasmas" and completed his PhD under the supervision of Bill Mathews. Roland extended the results of his thesis during two post-docs, first at

  4. [Bifocal atypical rolandic epilepsy with speech dyspraxia].

    PubMed

    Karlov, V A; Baiarrnaa Dondovyn; Gnezditskiĭ, V V

    2004-01-01

    Clinical and neurophysiological analysis of a case of a 7 year old patient with typical benign partial seizures with rolandic spikes and speech disorder, differing from those in Landau-Kleffner syndrome and in typical benign partial epilepsy of childhood presenting as speech dyspraxia. Two independent foci (in the premotor cortex of the left front lobe (dominant hemisphere) and in the temporal lobe of the right hemisphere were found. Significant clinical improvement and electrographical positive effect in EEG were achiered after prednisolone and sodium valproate treatment. PMID:15849864

  5. Sleep and behavioral problems in rolandic epilepsy.

    PubMed

    Samaitienė, Rūta; Norkūnienė, Jolita; Tumienė, Birutė; Grikinienė, Jurgita

    2013-02-01

    Although patients with benign childhood epilepsy with centrotemporal spikes exhibit a benign course of the disease, some of them display sleep and behavioral problems. Sixty-one patients with rolandic epilepsy, aged 6-11 years, were included in this study. The patients were divided into two subgroups according to the presence of seizures over the preceding 6 months. The control group comprised 25 patients without epilepsy and with similar characteristics in terms of age and sex. All patients underwent evaluation of sleep (Sleep Disturbance Scale for Children) and behavior (Lithuanian version of the Child Behaviour Checklist). Only patients who had had seizures over the preceding 6 months displayed significantly higher scores for sleep problems (disorders of excessive daytime sleepiness, disorders of sleep-wake transition, and scores for total sleep problems), worse sleep quality (longer sleep-onset latency), and behavioral problems (anxiety/depression, social problems, thought problems, attention problems, and aggressive behavior) than the patients of the control group. Our data add to evidence that active epilepsy has an impact on sleep and behavior. Clinically significant sleep problems were related to the higher risk of behavioral problems. Parents' ratings for existing sleep problems were sensitive to Sleep Disturbance Scale for Children scores above normal values. PMID:23337004

  6. Superculture? Thoughts Prompted by Roland S. Persson's Essay

    ERIC Educational Resources Information Center

    Tebbs, Trevor J.

    2012-01-01

    The author finds Roland S. Persson's (2012a) paper to be timely, fascinating, important and powerful. At risk of mixing metaphors, it provides much food for thought and a penetrating lens through which all those vested in the optimal realisation of human potential would be prudent to review their own perceptions, boundaries of belief and…

  7. Roland Barthes and Decomposing/Deterritorializing the Writing Classroom.

    ERIC Educational Resources Information Center

    Richmond, Joan L.

    Roland Barthes points out in his pedagogical essays that, although students have been filled with horror stories of professorial expectations, at the same time they have expectations of their own. Barthes' points should be considered as a way of examining the classroom space and common writing teaching practices and opening them up to different…

  8. Autosomal dominant rolandic epilepsy and speech dyspraxia: a new syndrome with anticipation.

    PubMed

    Scheffer, I E; Jones, L; Pozzebon, M; Howell, R A; Saling, M M; Berkovic, S F

    1995-10-01

    We describe a family of 9 affected individuals in three generations with nocturnal oro-facio-brachial partial seizures, secondarily generalized partial seizures, and centro-temporal epileptiform discharges, associated with oral and speech dyspraxia and cognitive impairment. The speech disorder was prominent, but differed from that of Landau-Kleffner syndrome and of epilepsy with continuous spike and wave during slow-wave sleep. The electroclinical features of this new syndrome of autosomal dominant rolandic epilepsy resemble those of benign rolandic epilepsy, a common inherited epilepsy of childhood. This family shows clinical anticipation of the seizure disorder, the oral and speech dyspraxia, and cognitive dysfunction, suggesting that the genetic mechanism could be expansion of an unstable triplet repeat. Molecular studies on this syndrome, where the inheritance pattern is clear, could also be relevant to identifying a gene for benign rolandic epilepsy where anticipation does not occur and the mode of inheritance is uncertain. PMID:7574460

  9. Incidental rolandic spikes: long-term outcomes and impact of treatment.

    PubMed

    McNally, Melanie A; Kossoff, Eric H

    2015-02-01

    We describe a group of 26 children with no prior history of seizures consistent with benign rolandic epilepsy who had rolandic spikes found coincidentally on EEG. A retrospective chart review as well as phone and email follow-ups with families were completed to assess long-term outcomes. A subset of this group (n=7) with reported comorbid language or learning difficulties was then given an empiric trial of levetiracetam. Seven (27%) children eventually developed seizures, with a median of 14months after the abnormal EEG. Of the 7 children ever treated with levetiracetam, 5 exhibited beneficial effects on learning, speech, or behavior. Side effects reported were mild and included irritability and headache. Incidental rolandic spikes may represent a discrete neurologic condition, with approximately one-quarter of the patients later developing epilepsy. Some of these children may experience improved intellectual functioning with levetiracetam. PMID:25623811

  10. Harm and the Ideal of the Educated Person: Response to Jane Roland Martin.

    ERIC Educational Resources Information Center

    Roemer, Eleanor Kallman

    1981-01-01

    This paper analyses and comments on an article by Jane Roland Martin (Educational Theory, v31 n2) concerning a masculine bias in the teaching of the intellectual disciplines. Roemer supports Martin's major arguments, including the idea that women are forced to accommodate to norms established for men. (PP)

  11. "Profound Levels of Learning" through Brain-Based Teaching: A Tribute to Roland Barth

    ERIC Educational Resources Information Center

    Shore, Rebecca Ann

    2012-01-01

    This article is a tribute to the writings of Dr. Roland Barth through a personal story spanning over two decades. It explores Dr. Barth's personal vision of an effective school through recent brain-based principles. It revisits Barth's axioms and uses recent implications from the neurosciences as new supporting evidence for their success in…

  12. Policy, Practice in Giftedness, and Research Methodologies: Response to Roland S. Persson's Article

    ERIC Educational Resources Information Center

    Matthews, Dona J.

    2012-01-01

    The author finds the target article "Cultural Variation and Dominance in a Globalised Knowledge Economy" to be a thoughtful exploration of an important topic for all social scientists, certainly including those who study gifted development and education. Roland S. Persson (2012a) raises many questions about policy and practice in giftedness…

  13. Reduced Structural Connectivity between Sensorimotor and Language Areas in Rolandic Epilepsy

    PubMed Central

    Besseling, René M. H.; Jansen, Jacobus F. A.; Overvliet, Geke M.; van der Kruijs, Sylvie J. M.; Ebus, Saskia C. M.; de Louw, Anton; Hofman, Paul A. M.; Vles, Johannes S. H.; Aldenkamp, Albert P.; Backes, Walter H.

    2013-01-01

    Introduction Rolandic epilepsy (RE) is a childhood epilepsy with centrotemporal (rolandic) spikes, that is increasingly associated with language impairment. In this study, we tested for a white matter (connectivity) correlate, employing diffusion weighted MRI and language testing. Methods Twenty-three children with RE and 23 matched controls (age: 8–14 years) underwent structural (T1-weighted) and diffusion-weighted MRI (b = 1200 s/mm2, 66 gradient directions) at 3T, as well as neuropsychological language testing. Combining tractography and a cortical segmentation derived from the T1-scan, the rolandic tract were reconstructed (pre- and postcentral gyri), and tract fractional anisotropy (FA) values were compared between patients and controls. Aberrant tracts were tested for correlations with language performance. Results Several reductions of tract FA were found in patients compared to controls, mostly in the left hemisphere; the most significant effects involved the left inferior frontal (p = 0.005) and supramarginal (p = 0.004) gyrus. In the patient group, lower tract FA values were correlated with lower language performance, among others for the connection between the left postcentral and inferior frontal gyrus (p = 0.043, R = 0.43). Conclusion In RE, structural connectivity is reduced for several connections involving the rolandic regions, from which the epileptiform activity originates. Most of these aberrant tracts involve the left (typically language mediating) hemisphere, notably the pars opercularis of the inferior frontal gyrus (Broca’s area) and the supramarginal gyrus (Wernicke’s area). For the former, reduced language performance for lower tract FA was found in the patients. These findings provide a first microstructural white matter correlate for language impairment in RE. PMID:24376719

  14. Semiology of typical and atypical Rolandic epilepsy: a video-EEG analysis.

    PubMed

    Saint-Martin, A D; Carcangiu, R; Arzimanoglou, A; Massa, R; Thomas, P; Motte, J; Marescaux, C; Metz-Lutz, M N; Hirsch, E

    2001-12-01

    Since the first descriptions of Rolandic Epilepsy or benign epilepsy with centrotemporal spikes (BECTS), typical and atypical forms have been reported. Indeed, classical focal seizures are sometimes associated with various atypical ictal symptoms and cognitive or behavioural disorders. In an effort to define early clinical and EEG criteria allowing early distinction between typical and atypical forms, we recently conducted a prospective study in a cohort of children with Rolandic Epilepsy. The results of this study have been reported elsewhere. We now discuss the semiological characteristics, and comment on the video-EEG data collected during this study. Symptoms were classified into three major categories: "classical focal seizures"; "spike and wave related symptoms"; and "paraictal symptoms". Classical focal seizures constitute the electroclinical expression of the development and the propagation of a focal cortical neuronal discharge. "Spike and wave related symptoms" are brief neurological or neuropsychological phenomena having a relatively strict temporal relation with individual components of isolated focal or generalized spikes and waves. "Paraictal symptoms" consist of acquired progressive and fluctuating motor or cognitive deficits and are not directly correlated with Todd paralysis. We present detailed video-EEG material of selected cases and discuss the usefulness of such distinctions in terminology. We suggest that variability in clinical expression probably reflects the implication of different pathophysiological mechanisms, which in turn could explain differences in sensitivity to treatment. (Published with videosequences.) PMID:11844712

  15. Resting state Rolandic mu rhythms are related to activity of sympathetic component of autonomic nervous system in healthy humans.

    PubMed

    Triggiani, Antonio Ivano; Valenzano, Anna; Del Percio, Claudio; Marzano, Nicola; Soricelli, Andrea; Petito, Annamaria; Bellomo, Antonello; Başar, Erol; Mundi, Ciro; Cibelli, Giuseppe; Babiloni, Claudio

    2016-05-01

    We tested the hypothesis of a relationship between heart rate variability (HRV) and Rolandic mu rhythms in relaxed condition of resting state. Resting state eyes-closed electroencephalographic (EEG) and electrocardiographic (ECG) data were recorded (10-20 System) in 42 healthy adults. EEG rhythms of interest were high-frequency alpha (10.5-13Hz) and low-frequency beta (13-20Hz), which are supposed to form Rolandic mu rhythms. Rolandic and occipital (control) EEG sources were estimated by LORETA software. Results showed a statistically significant (p<0.05, corrected) negative correlation across all subjects between Rolandic cortical sources of low-frequency beta rhythms and the low-frequency band power (LF, 0.04-0.15Hz) of tachogram spectrum as an index of HRV. The lower the amplitude of Rolandic sources of low-frequency beta rhythms (as a putative sign of activity of somatomotor cortex), the higher the LF band power of tachogram spectrum (as a putative sign of sympathetic activity). This effect was specific as there was neither a similar correlation between these EEG rhythms and high-frequency band power of tachogram spectrum (as a putative sign of parasympathetic vagal activity) neither between occipital sources of low-frequency beta rhythms (as a putative sign of activity of visual cortex) and LF band power of tachogram spectrum. These results suggest that Rolandic low-frequency beta rhythms are related to sympathetic activity regulating heart rate, as a dynamic neurophysiologic oscillatory mechanism sub-serving the interaction between brain neural populations involved in somatomotor control and brain neural populations regulating ANS signals to heart for on-going homeostatic adaptations. PMID:25660308

  16. Modulation of Rolandic Beta-Band Oscillations during Motor Simulation of Joint Actions

    PubMed Central

    Ménoret, Mathilde; Bourguignon, Mathieu; Hari, Riitta

    2015-01-01

    Successful joint actions require precise temporal and spatial coordination between individuals who aim to achieve a common goal. A growing number of behavioral data suggest that to efficiently couple and coordinate a joint task, the actors have to represent both own and the partner’s actions. However it is unclear how the motor system is specifically recruited for joint actions. To find out how the goal and the presence of the partner’s hand can impact the motor activity during joint action, we assessed the functional state of 16 participants’ motor cortex during observation and associated motor imagery of joint actions, individual actions, and non-goal-directed actions performed with either 1 or 2 hands. As an indicator of the functional state of the motor cortex, we used the reactivity of the rolandic magnetoencephalographic (MEG) beta rhythm following median-nerve stimulation. Motor imagery combined with action observation was associated with activation of the observer’s motor cortex, mainly in the hemisphere contralateral to the viewed (and at the same time imagined) hand actions. The motor-cortex involvement was enhanced when the goal of the actions was visible but also, in the ipsilateral hemisphere, when the partner’s hand was visible in the display. During joint action, the partner’s action, in addition to the participant’s own action, thus seems to be represented in the motor cortex so that it can be triggered by the mere presence of an acting hand in the peripersonal space. PMID:26151634

  17. 16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy.

    PubMed

    Reinthaler, Eva M; Lal, Dennis; Lebon, Sebastien; Hildebrand, Michael S; Dahl, Hans-Henrik M; Regan, Brigid M; Feucht, Martha; Steinböck, Hannelore; Neophytou, Birgit; Ronen, Gabriel M; Roche, Laurian; Gruber-Sedlmayr, Ursula; Geldner, Julia; Haberlandt, Edda; Hoffmann, Per; Herms, Stefan; Gieger, Christian; Waldenberger, Melanie; Franke, Andre; Wittig, Michael; Schoch, Susanne; Becker, Albert J; Hahn, Andreas; Männik, Katrin; Toliat, Mohammad R; Winterer, Georg; Lerche, Holger; Nürnberg, Peter; Mefford, Heather; Scheffer, Ingrid E; Berkovic, Samuel F; Beckmann, Jacques S; Sander, Thomas; Jacquemont, Sebastien; Reymond, Alexandre; Zimprich, Fritz; Neubauer, Bernd A

    2014-11-15

    Rolandic epilepsy (RE) is the most common idiopathic focal childhood epilepsy. Its molecular basis is largely unknown and a complex genetic etiology is assumed in the majority of affected individuals. The present study tested whether six large recurrent copy number variants at 1q21, 15q11.2, 15q13.3, 16p11.2, 16p13.11 and 22q11.2 previously associated with neurodevelopmental disorders also increase risk of RE. Our association analyses revealed a significant excess of the 600 kb genomic duplication at the 16p11.2 locus (chr16: 29.5-30.1 Mb) in 393 unrelated patients with typical (n = 339) and atypical (ARE; n = 54) RE compared with the prevalence in 65,046 European population controls (5/393 cases versus 32/65,046 controls; Fisher's exact test P = 2.83 × 10(-6), odds ratio = 26.2, 95% confidence interval: 7.9-68.2). In contrast, the 16p11.2 duplication was not detected in 1738 European epilepsy patients with either temporal lobe epilepsy (n = 330) and genetic generalized epilepsies (n = 1408), suggesting a selective enrichment of the 16p11.2 duplication in idiopathic focal childhood epilepsies (Fisher's exact test P = 2.1 × 10(-4)). In a subsequent screen among children carrying the 16p11.2 600 kb rearrangement we identified three patients with RE-spectrum epilepsies in 117 duplication carriers (2.6%) but none in 202 carriers of the reciprocal deletion. Our results suggest that the 16p11.2 duplication represents a significant genetic risk factor for typical and atypical RE. PMID:24939913

  18. Delayed convergence between brain network structure and function in rolandic epilepsy

    PubMed Central

    Besseling, René M. H.; Jansen, Jacobus F. A.; Overvliet, Geke M.; van der Kruijs, Sylvie J. M.; Ebus, Saskia C. M.; de Louw, Anton J. A.; Hofman, Paul A. M.; Aldenkamp, Albert P.; Backes, Walter H.

    2014-01-01

    Introduction: Rolandic epilepsy (RE) manifests during a critical phase of brain development, and has been associated with language impairments. Concordant abnormalities in structural and functional connectivity (SC and FC) have been described before. As SC and FC are under mutual influence, the current study investigates abnormalities in the SC-FC synergy in RE. Methods: Twenty-two children with RE (age, mean ± SD: 11.3 ± 2.0 y) and 22 healthy controls (age 10.5 ± 1.6 y) underwent structural, diffusion weighted, and resting-state functional magnetic resonance imaging (MRI) at 3T. The probabilistic anatomical landmarks atlas was used to parcellate the (sub)cortical gray matter. Constrained spherical deconvolution tractography and correlation of time series were used to assess SC and FC, respectively. The SC-FC correlation was assessed as a function of age for the non-zero structural connections over a range of sparsity values (0.01–0.75). A modularity analysis was performed on the mean SC network of the controls to localize potential global effects to subnetworks. SC and FC were also assessed separately using graph analysis. Results: The SC-FC correlation was significantly reduced in children with RE compared to healthy controls, especially for the youngest participants. This effect was most pronounced in a left and a right centro-temporal network, as well as in a medial parietal network. Graph analysis revealed no prominent abnormalities in SC or FC network organization. Conclusion: Since SC and FC converge during normal maturation, our finding of reduced SC-FC correlation illustrates impaired synergy between brain structure and function. More specifically, since this effect was most pronounced in the youngest participants, RE may represent a developmental disorder of delayed brain network maturation. The observed effects seem especially attributable to medial parietal connections, which forms an intermediate between bilateral centro-temporal modules of

  19. Revealing Additional Dimensions of Globalisation and Cultural Hegemony: A Response to Roland S. Persson's Call for Cultural Sensitivity in Gifted Studies

    ERIC Educational Resources Information Center

    Ambrose, Don

    2012-01-01

    In this commentary, the author finds the interdisciplinary approach of Roland S. Persson's (2012a) target article refreshing. Persson's (2012a) additional emphases on ethnocentricity, cultural bias and strong threads of influence from the global economy also are helpful. They shed light on some strong contextual influences that shape the…

  20. Gender Anarchy as Social Justice: An Analytic Reconstruction of the Idea of Epistemic Equality in Jane Roland Martin's "Reclaiming a Conversation"

    ERIC Educational Resources Information Center

    Seals, Greg

    2006-01-01

    Jane Roland Martin's later work, especially as represented in "The Schoolhome: Rethinking Schools for Changing Families," has been attacked as vague, essentialistic, and a formula for the (re)feminization of education. This paper does not attempt to defend Martin against these criticisms because such a defense seems impossible for…

  1. Neuropsychological disorders related to interictal epileptic discharges during sleep in benign epilepsy of childhood with centrotemporal or Rolandic spikes.

    PubMed

    Baglietto, M G; Battaglia, F M; Nobili, L; Tortorelli, S; De Negri, E; Calevo, M G; Veneselli, E; De Negri, M

    2001-06-01

    Nine children (five males, four females; age range 6 years 1 month to 11 years 1 month) affected by benign epilepsy of childhood with centrotemporal or Rolandic spikes (BECRS) with EEG evidence of marked activation of interictal epileptic discharges (IEDs) during sleep, and nine unaffected control children matched for age, sex, and socioeconomic status, were enrolled in a prospective study. At the time of detection of IED activation during sleep, patients showed a mean Full-Scale IQ score within the normal range, but significantly below that of control participants; neuropsychological assessment revealed disorders in visuospatial short-term memory (Corsi's Block Tapping Test), attention, and cognitive flexibility (Trail Making Test and Stroop Color-Word Test), picture naming, and fluency (Benton's Naming Test and Word Fluency), visuoperceptual skill (Ghent-Poppelreuter and Street Gestalt Completion Tests) and visuomotor coordination (Bender Test). After detection of IED activation during sleep, children were followed up for 2 years. At the time of IED remission (T1), neuropsychological re-evaluation showed a notable increase in IQ score and a significant improvement (t-test: p<0.007) in visuomotor coordination, non-verbal short-term memory, sustained attention and mental flexibility, picture naming, and visual-perceptual performance. At T1, patients' performance did not differ from the controls (Mann-Whitney U test). PMID:11409830

  2. Reliability and Validity of Simplified Chinese Version of Roland-Morris Questionnaire in Evaluating Rural and Urban Patients with Low Back Pain

    PubMed Central

    Chen, Ziqiang; Wang, Xinhui; Zhu, Xiaodong; Zhang, Wei; Chen, Jiayu; Zhang, Diqing; Li, Ming

    2012-01-01

    Objective The causes of low back pain in China and Western countries are extremely different. We attempted to analyze the risk factors of low back pain in urban and rural patients under the dual economy with the simplified Chinese version of Roland-Morris disability questionnaire (SC-RMDQ) to demonstrate that SC-RMDQ could evaluate patients with low back pain arising from different causes. Methods Roland-Morris disability questionnaire was translated into SCRMDQ according to international guidelines for questionnaire adaptation. In this study, causes of low back pain of 187 outpatients and inpatients (99 urban patients and 88 rural patients) were analyzed. All patients underwent simplified Chinese version of Roland-Morris disability questionnaire (SC-RMDQ), simplified Chinese Oswestry disability index (SCODI) and visual analogue scale (VAS). Reliability was tested using reproducibility (intraclass coefficient of correlation – ICC) and internal consistency (Cronbach's alpha). Validity was tested using Pearson correlation analysis. Results The leading causes for low back pain were sedentariness (38.4%) and vibration (18.1%) in urban patients and waist bending (48.9%) and spraining (25%) in rural patients. Although causes of low back pain in the two groups of population were completely different, SCRMDQ had high internal consistency (Cronbach's α value of 0.874 in urban patients and 0.883 in rural patients) and good reproducibility (ICC value of .952 in urban patients and 0.949 in rural patients, P<0.01). SCRMDQ also showed significant correlation with Simplified Chinese version of Oswestry disability index (SCODI) and visual analogue scale (VAS) in rural areas (SCRMDQ-SCODI r = 0.841; SCRMDQ -VAS: r = 0.685, P<0.01) and in urban areas (SCRMDQ-SCODI: r = 0.818, P<0.01; SCRMDQ –VAS: r = 0.666, P<0.01). Conclusions Although causes of low back pain are completely different in rural and urban patients, SCRMDQ has a good reliability and validity, which

  3. Evaluation of a neurotherapy program for a child with ADHD with Benign Partial Epilepsy with Rolandic Spikes (BPERS) using event-related potentials

    PubMed Central

    Pąchalska, Maria; Kropotov, Iurii D.; Mańko, Grzegorz; Lipowska, Małgorzata; Rasmus, Anna; Łukaszewska, Beata; Bogdanowicz, Marta; Mirski, Andrzej

    2012-01-01

    Summary Background We hypothesized that there would be a good response to relative beta training, applied to regulate the dynamics of brain function in a patient with benign partial epilepsy with Rolandic Spikes (BPERS), associated with neuropsychiatric deficits resembling the symptoms of attention deficit-hyperactivity disorder (ADHD). Case Report The patient, E.Z., age 9.3, was suffering from neuropsychiatric symptoms, cognitive dysfunction, especially attention deficits, and behavioral changes, rendering him unable to function independently in school and in many situations of everyday life. He was treated for epilepsy, but only slight progress was made. The patient took part in 20 sessions of relative beta training combined with behavioral training. We used standardized neuropsychological testing, as well as ERPs before the experiment and after the completion of the neurotherapy program. Neuropsychological testing at baseline showed multiple cognitive deficits. Over the course of neurotherapy, E.Z.’s verbal and non-verbal IQ increased significantly. His cognitive functions also improved, including immediate and delayed logical and visual recall on the WMS-III, maintaining attention on the WMS-III, and executive functions, but remained below norms. Physiologically, the patient showed substantial changes after neurotherapy, including fewer spikes and an increased P300 NOGO component. Conclusions The cognitive deficits characteristic for ADHD in a child with BPERS may be unresponsive to antiepileptic treatment, but are reversible after a carefully selected neurotherapy program, combined with antiepileptic treatment. Event Related Potentials (ERPs) in the GO/NOGO task can be used to assess functional brain changes induced by neurotherapeutical programs. PMID:23111748

  4. Identification of Reliable Sulcal Patterns of the Human Rolandic Region.

    PubMed

    Mellerio, Charles; Lapointe, Marie-Noël; Roca, Pauline; Charron, Sylvain; Legrand, Laurence; Meder, Jean-François; Oppenheim, Catherine; Cachia, Arnaud

    2016-01-01

    A major feature of the human cortex is its huge morphological variability. Although a comprehensive literature about the sulco-gyral pattern of the central region is available from post-mortem data, a reliable and reproducible characterization from in vivo data is still lacking. The aim of this study is to test the reliability of morphological criteria of the central region sulci used in post-mortem data, when applied to in vivo magnetic resonance imaging (MRI) data. Thirty right-handed healthy individuals were included in the study. Automated segmentation and three dimensional (3D) surface-based rendering were obtained from clinical 3D T1-weighted MRI. Two senior radiologists labeled the three sulci composing the central region (precentral [PreCS], central [CS] and postcentral [PostCS]) and analyzed their morphological variations using 47 standard criteria derived from Ono's atlas based on post-mortem data. For each criterion, inter-rater concordance and comparison with the occurrence frequency provided in Ono's atlas were estimated. Overall, the sulcal pattern criteria derived from MRI data were highly reproducible between the raters with a high mean inter-rater concordance in the three sulci (CS: κ = 0.92 in left hemisphere/κ = 0.91 in right hemisphere; PreCS: κ = 0.91/κ = 0.93; PostCS: κ = 0.84/0.79). Only a very limited number of sulcal criteria significantly differed between the in vivo and the post-mortem data (CS: 2 criteria in the left hemisphere/3 criteria in the right hemisphere; PreCS: 3 in the left and right hemispheres; PostCS: 3 in the left hemisphere and 5 in the right hemisphere). Our study provides a comprehensive description of qualitative sulcal patterns in the central region from in vivo clinical MRI with high agreement with previous post-mortem data. Such identification of reliable sulcal patterns of the central region visible with standard clinical MRI data paves the way for the detection of subtle variations of the central sulcation associated with variations of normal or pathological functioning. PMID:27582700

  5. The Roland Maze Project — Cosmic Ray Registration at Schools

    NASA Astrophysics Data System (ADS)

    Feder, J.; JȨDRZEJCZAK, K.; Karczmarczyk, J.; Lewandowski, R.; Swarzyński, J.; Szabelska, B.; Szabelski, J.; Tokarski, P.; Wibig, T.

    Experimental studies of cosmic rays at the highest energies (above 1018 eV) are the main scientific goal of the projected large area network of extensive air shower detectors. Placing the detectors on the roofs of high school buildings will lower the cost by using the existing urban infrastructure (INTERNET, power supply, etc.), and can be a very efficient way of science popularisation by engaging high school students in the research program. 30 high schools in Łódź are already involved in the project. The project has recently obtained some financial support from the City Council of Łódź. The donation enabled us to start experimental work on detector construction details. A cycle of lectures and seminars devoted to different aspects of project realization (detector construction, on-line data acquisition system, C++ programming) has been organized for students at our Institute and at schools.

  6. Identification of Reliable Sulcal Patterns of the Human Rolandic Region

    PubMed Central

    Mellerio, Charles; Lapointe, Marie-Noël; Roca, Pauline; Charron, Sylvain; Legrand, Laurence; Meder, Jean-François; Oppenheim, Catherine; Cachia, Arnaud

    2016-01-01

    A major feature of the human cortex is its huge morphological variability. Although a comprehensive literature about the sulco-gyral pattern of the central region is available from post-mortem data, a reliable and reproducible characterization from in vivo data is still lacking. The aim of this study is to test the reliability of morphological criteria of the central region sulci used in post-mortem data, when applied to in vivo magnetic resonance imaging (MRI) data. Thirty right-handed healthy individuals were included in the study. Automated segmentation and three dimensional (3D) surface-based rendering were obtained from clinical 3D T1-weighted MRI. Two senior radiologists labeled the three sulci composing the central region (precentral [PreCS], central [CS] and postcentral [PostCS]) and analyzed their morphological variations using 47 standard criteria derived from Ono’s atlas based on post-mortem data. For each criterion, inter-rater concordance and comparison with the occurrence frequency provided in Ono’s atlas were estimated. Overall, the sulcal pattern criteria derived from MRI data were highly reproducible between the raters with a high mean inter-rater concordance in the three sulci (CS: κ = 0.92 in left hemisphere/κ = 0.91 in right hemisphere; PreCS: κ = 0.91/κ = 0.93; PostCS: κ = 0.84/0.79). Only a very limited number of sulcal criteria significantly differed between the in vivo and the post-mortem data (CS: 2 criteria in the left hemisphere/3 criteria in the right hemisphere; PreCS: 3 in the left and right hemispheres; PostCS: 3 in the left hemisphere and 5 in the right hemisphere). Our study provides a comprehensive description of qualitative sulcal patterns in the central region from in vivo clinical MRI with high agreement with previous post-mortem data. Such identification of reliable sulcal patterns of the central region visible with standard clinical MRI data paves the way for the detection of subtle variations of the central sulcation associated with variations of normal or pathological functioning. PMID:27582700

  7. Atypical hemispheric asymmetries for the processing of phonological features in children with rolandic epilepsy.

    PubMed

    Bedoin, Nathalie; Ferragne, Emmanuel; Lopez, Céline; Herbillon, Vania; De Bellescize, J; des Portes, Vincent

    2011-05-01

    We assessed language lateralization in 177 healthy 4- to 11-year-old children and adults and atypical asymmetries associated with unilateral epileptic foci in 18 children with benign epilepsy with centrotemporal spikes (BECTS). Dichotic listening results revealed two indices of immature functional asymmetry when the focus was left-sided (BECTS-L). First, children with BECTS-L did not show left hemisphere dominance for the processing of place of articulation, which was recorded in children with BECTS-R and control children. On the contrary, healthy children exhibited a gradual increase in left hemisphere dominance for place processing during childhood, which is consistent with the shift from global to finer-grained acoustic analysis predicted by the Developmental Weighting Shift model. Second, children with BECTS-L showed atypical left hemisphere involvement in the processing of the voiced value (+V), associated with a long acoustic event in French stop consonants, whereas right hemisphere dominance increased with age for +V processing in healthy children. BECTS-L, therefore, interferes with the development of left hemisphere dominance for specific phonological mechanisms. PMID:21470917

  8. Eötvös, Baron Lóránd [Roland] von (1848-1919)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Hungarian physicist, born in Pest (now part of Budapest), became professor of experimental physics there. Worked on wide range of physical problems including gravitation, and invented the Eötvös balance, a torsion balance. With it, he tested (in what became known as the Eötvös experiment) the equivalence principle that gravitational mass and inertial mass are equivalent; he found that they were i...

  9. The Roland Maze Project school-based extensive air shower network

    NASA Astrophysics Data System (ADS)

    Feder, J.; Jȩdrzejczak, K.; Karczmarczyk, J.; Lewandowski, R.; Swarzyński, J.; Szabelska, B.; Szabelski, J.; Wibig, T.

    2006-01-01

    We plan to construct the large area network of extensive air shower detectors placed on the roofs of high school buildings in the city of Łódź. Detection points will be connected by INTERNET to the central server and their work will be synchronized by GPS. The main scientific goal of the project are studies of ultra high energy cosmic rays. Using existing town infrastructure (INTERNET, power supply, etc.) will significantly reduce the cost of the experiment. Engaging high school students in the research program should significantly increase their knowledge of science and modern technologies, and can be a very efficient way of science popularisation. We performed simulations of the projected network capabilities of registering Extensive Air Showers and reconstructing energies of primary particles. Results of the simulations and the current status of project realisation will be presented.

  10. Language in Benign Childhood Epilepsy with Centro-Temporal Spikes Abbreviated Form: Rolandic Epilepsy and Language

    ERIC Educational Resources Information Center

    Monjauze, C.; Tuller, L.; Hommet, C.; Barthez, M.A.; Khomsi, A.

    2005-01-01

    Although Benign Childhood Epilepsy with Centrotemporal Spikes (BECTS) has a good prognosis, a few studies have suggested the existence of language disorders relating to the interictal dysfunction of perisylvian language areas. In this study, we focused on language assessment in 16 children aged 6-15 currently affected by BECTS or in remission. An…

  11. Sleep-related, low voltage Rolandic and vertex spikes: an EEG marker of benignity in infancy-onset focal epilepsies.

    PubMed

    Bureau, Michelle; Cokar, Ozlem; Maton, Bruno; Genton, Pierre; Dravet, Charlotte

    2002-03-01

    Although benign forms of epilepsies with onset in infancy have recently been recognized, the occurrence of seizures in an infant or very young child is very often an event of great significance and the prognosis concerning both epilepsy and neuropsychological development must be guarded. No reliable clinical or electroencephalographic (EEG) markers that can predict the outcome have been described. In a retrospective series of 10 patients, we found a peculiar EEG pattern seen across sleep stages, but not in the waking state in infants whose first seizures appeared before the age of 1 year, and which were mostly complex focal. In all cases, follow-up showed a favourable outcome with complete seizure remission and no cognitive impairment. The specificity of these EEG changes was 100%, but the sensitivity was lower, since they were not seen in some of the infants with the same favourable outcome. We discuss the clinical similarities between our patients and those cases reported earlier by other authors as benign, non-familial or familial focal epilepsies, in whom, however, no interictal abnormalities had been seen on the EEG. Such EEG changes are probably specific to benign, self-limited, early onset focal epilepsies. PMID:11967175

  12. The Role of Selenium in HIV Infection Cosby A Stone, Kosuke Kawai, Roland Kupka, Wafaie W Fawzi Harvard School of Public Health

    PubMed Central

    Stone, Cosby A; Kawai, Kosuke; Kupka, Roland; Fawzi, Wafaie W.

    2010-01-01

    HIV infection is a global disease that disproportionately burdens populations with nutritional vulnerabilities. Laboratory experiments have shown that selenium has an inhibitory effect on HIV in vitro through antioxidant effects of glutathione peroxidase and other selenoproteins. Numerous studies have reported low selenium status in HIV-infected individuals, and serum selenium concentration declines with disease progression. Some cohort studies have shown an association between selenium deficiency and progression to AIDS or mortality. In several randomized controlled trials, selenium supplementation has reduced hospitalizations, diarrheal morbidity, and improved CD4 cell counts, but the evidence remains mixed. Additional trials are recommended to study the effect of selenium supplementation on opportunistic infections, and other HIV disease related comorbidities in the context of highly active antiretroviral therapy in both developing and developed countries. PMID:20961297

  13. 9. GATEHOUSE, INTERIOR, COUNTERSHAFT WHICH HELD BELT ATTACHED TO ENGINE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. GATEHOUSE, INTERIOR, COUNTERSHAFT WHICH HELD BELT ATTACHED TO ENGINE FOR HYPOCHLORITE MIXER, VIEW EAST - Lake Roland Dam, Gatehouse, Spanning outlet of Lake Roland near Woodbridge Road, Towson, Baltimore County, MD

  14. Acquired Language Disorders.

    ERIC Educational Resources Information Center

    Raymer, Anastasia M.

    2001-01-01

    This article discusses advances in structural and functional neuroimaging that indicate that, in general, nonfluent aphasias are associated with left pre-rolandic lesions and fluent aphasias occur with left post-rolandic lesions that spare pre-rolandic areas. However, functional neuroimaging studies have also shown that neural dysfunction often…

  15. Proceedings of the College Reading Association, Volume 10, Fall 1969.

    ERIC Educational Resources Information Center

    Ketcham, Clay A., Ed.

    The proceedings of the twelfth annual meeting of the College Reading Association (with a focus on "Reading: Today's Needs, Tomorrow's Challenges") consisted of the following papers: "President's Address" (J. R. Newton); "Structure, Stricture in Reading Programs" (M. J. Weiss); "Why Use Informal Reading Inventories" (J. P. Kender); "Some…

  16. How Exercise Can Help

    MedlinePlus Videos and Cool Tools

    ... be active. That is, they need to improve muscle tone around the joint -- it actually protects the joint. Dr. Roland Moskowitz: If you strengthen the muscles and stabilize the joint, you decrease the instability ...

  17. Aping our ancestors

    NASA Astrophysics Data System (ADS)

    Ennos, Roland

    2014-08-01

    Roland Ennos argues that the abilities of the great apes to cope in the dangerous mechanical environment of the forest canopy are part of the human species' intellectual inheritance and are intimately connected with our abilities as physicists.

  18. Oscillatory brain states interact with late cognitive components of the somatosensory evoked potential.

    PubMed

    Reinacher, Matthias; Becker, Robert; Villringer, Arno; Ritter, Petra

    2009-09-30

    The question of interaction between ongoing neuronal activity and evoked responses has been addressed for different species, sensory systems and measurement modalities. Among other findings, there is converging evidence for an interaction of occipital alpha-rhythm amplitude with the visual evoked potential. Here, we test the hypothesis that the modulatory role of an ongoing rhythm might not be confined to the visual system and the occipital alpha rhythm, but instead may be generalized to other sensory systems. Using an online EEG analysis approach, we investigated the influence of the Rolandic alpha-rhythm on the somatosensory evoked potential (SEP). We triggered vibrotactile stimulation during periods of high Rolandic alpha-rhythm amplitude. Analysis revealed significant effects of pre-stimulus Rolandic alpha amplitude on the amplitude of the N140 and P260 components of the SEP, known to be linked to cognitive processing, but not on early sensory components. The N140-P260 complex shows a different focus in topography than the early sensory components and the pre-stimulus Rolandic alpha rhythm. These results indicate an involvement of Rolandic alpha-rhythm in higher cognitive processing. In more general terms--and in the context of similar studies in the visual system--our findings suggest that modulation of late EP components by ongoing rhythms might be a characteristic and possibly universal feature of sensory systems. PMID:19589356

  19. The role of the right hemisphere in the control of speech prosody in propositional and affective contexts.

    PubMed

    Shapiro, B E; Danly, M

    1985-05-01

    Sixteen right-handed adult males with localized insult to either the right or left hemisphere and five control subjects without brain damage read aloud target sentences embedded in paragraphs, while intoning their voices in either a declarative, interrogative, happy, or sad mode. Acoustical analysis of the speech wave was performed. Right-anterior (pre-Rolandic) and right-central (pre- and post-Rolandic) brain-damaged patients spoke with less pitch variation and restricted intonational range across emotional and nonemotional domains, while patients with right posterior (post-Rolandic) damage had exaggerated pitch variation and intonational range across both domains. No such deficits were found in patients with left posterior damage, whose prosody was similar to that of normal control subjects. It is suggested that damage to the right hemisphere alone may result in a primary disturbance of speech prosody that may be independent of the disturbances in affect often noted in right-brain-damaged populations. PMID:4027566

  20. The Debate on Dominant Culture and Cultural Imperialism

    ERIC Educational Resources Information Center

    Anchan, John P.

    2012-01-01

    In this commentary, the author reviews in depth Roland S. Persson's (2012a) target article. According to him Persson (2012a) presents a convincing argument as he wove through examples and explanations. The idea of superculture connects well with the established neocolonial literature and the North-South/Centre-Periphery debate. From general to…

  1. Expression of Self-Concept and Adjustment against Repeated Aggressions: The Case of a Longitudinal Study on School Bullying

    ERIC Educational Resources Information Center

    Houbre, Barbara; Tarquinio, Cyril; Lanfranchi, Jean-Baptiste

    2010-01-01

    Bullying between students in the school setting is an increasing problem. Bullying can be defined as any form of repeated mental or physical violence carried out by one or several individuals on a person who is not capable of defending himself (Roland and Idsoe, "Aggress Behav" 27:446-462, 2001). The aim of this paper is to observe the expression…

  2. Educational Studies of Cosmic Rays with a Telescope of Geiger-Muller Counters

    ERIC Educational Resources Information Center

    Wibig, T.; Kolodziejczak, K.; Pierzynski, R.; Sobczak, R.

    2006-01-01

    A group of high school students (XII Liceum) in the framework of the Roland Maze Project has built a compact telescope of three Geiger-Muller counters. The connection between the telescope and a PC computer was also created and programmed by students involved in the Project. This has allowed students to use their equipment to perform serious…

  3. Comet Bennett 1970 II.

    NASA Technical Reports Server (NTRS)

    Sekanina, Z.; Miller, F. D.

    1973-01-01

    The model for dust comets, formulated by Finson and Probstein, which had previously been tested only on Comet Arend-Roland 1957 III, has been successfully applied to three calibrated photographic plates of Comet Bennett. The size distribution, emission rate, and initial velocities of dust particles emitted from the comet's nucleus are given.

  4. A Path to Academic Excellence

    ERIC Educational Resources Information Center

    Grizzard, Clare; Woerner, Georgia K.

    2010-01-01

    Educators in Roland Park Elementary/Middle School in Baltimore recognize the essential role that the arts play in education. This K-8 urban public school, which serves a highly diverse population, focuses on academic excellence and high standards for students and faculty. They believe that teaching "in and through the arts" helps to achieve those…

  5. Bibliographic Annual in Speech Communication: 1974. Volume 5.

    ERIC Educational Resources Information Center

    Kennicott, Patrick C., Ed.

    This annotated bibliography is an annual volume devoted to maintaining a record of graduate work in speech communication, providing abstracts of doctoral dissertations, and making subject area bibliographies available. The contents of this volume include "Studies in Mass Communication: A Selected Bibliography, 1973" by Roland C. Johnson and…

  6. 76 FR 63677 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... Federal Register at http://www.gpoaccess.gov/fr/ . A consolidated listing of all authorities as of June 30... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  7. 75 FR 67408 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ....gpoaccess.gov/fr/ . A consolidated listing of all authorities as of June 30 is also published each year. The... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  8. 76 FR 31644 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards, Senior.../2011 Secretary. Projects. Farm Service Agency... Special Assistant.... DA110042 3/24/2011 Department...

  9. 75 FR 35095 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ....gov/fr/ fr/. A consolidated listing of all authorities as of June 30 is also published each year. The... MANAGEMENT Excepted Service AGENCY: Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This gives... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  10. 75 FR 11206 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ....gpoaccess.gov/fr/ . A consolidated listing of all authorities as of June 30 is also published each year. The... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  11. 76 FR 66764 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-27

    ... the Federal Register at http://www.gpoaccess.gov/fr/ fr/. A consolidated listing of all authorities as... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  12. 75 FR 28306 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-20

    ....gpoaccess.gov/fr/ fr/. A consolidated listing of all authorities as of June 30 is also published each year... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  13. 76 FR 38709 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-01

    ... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards, Senior.......... DA110040 4/4/2011 Secretary Farm and Foreign Agricultural Service. Rural Utilities Senior...

  14. 76 FR 2929 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-18

    ....gpoaccess.gov/fr/ . A consolidated listing of all authorities as of June 30 is also published each year. The... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  15. 75 FR 14214 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ....gpoaccess.gov/fr/ . A consolidated listing of all authorities as of June 30 is also published each year. The... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  16. 75 FR 52376 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ....gov/fr/ . A consolidated listing of all authorities as of June 30 is also published each year. The... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  17. 75 FR 3947 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ....gpoaccess.gov/ fr/. A consolidated listing of all authorities as of June 30 is also published each year. The... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  18. 75 FR 79052 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ....gpoaccess.gov/fr/ gov/fr/. A consolidated listing of all authorities as of June 30 is also published each... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  19. 76 FR 53157 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-25

    ... Federal Register at http://www.gpoaccess.gov/fr/ fr/. A consolidated listing of all authorities as of June... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  20. 76 FR 78316 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... published monthly in the Federal Register at http://www.gpoaccess.gov/ fr/. A consolidated listing of all... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  1. 76 FR 76199 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-06

    ... in the Federal Register at http://www.gpoaccess.gov/fr/ fr/. A consolidated listing of all... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  2. 76 FR 21411 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards, Senior...; E.O. 10577, 3 CFR 1954-1958 Comp., p. 218. John Berry, Director, U.S. Office of Personnel...

  3. 76 FR 9837 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ....gpoaccess.gov/fr/ . A consolidated listing of all authorities as of June 30 is also published each year. The... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  4. 75 FR 23308 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-03

    ....gpoaccess.gov/fr/ . A consolidated listing of all authorities as of June 30 is also published each year. The... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  5. 76 FR 13241 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards, Senior...: 5 U.S.C. 3301 and 3302; E.O. 10577, 3 CFR 1954-1958 Comp., p. 218. U.S. Office of...

  6. 75 FR 47031 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ....gov/fr/ fr/. A consolidated listing of all authorities as of June 30 is also published each year. The... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  7. Discovery of the Self through the Writing Process: Autobiography as a Heuristic of Identity.

    ERIC Educational Resources Information Center

    Pitts, Mary Ellen

    Although the recent thrust toward writing as interaction with a text has led to de-emphasis of personal-experience writing per se, autobiography, if approached in the context of textuality (in Roland Barthes's sense), can provide a model for writing as a means of discovering one's identity--of interacting with life as text and with the written…

  8. No Such Thing as a Consensus: Olive Banks and the Sociology of Education

    ERIC Educational Resources Information Center

    Delamont, Sara

    2008-01-01

    The title of this article comes from the editorial written for this journal by Olive Banks, Len Barton, Roger Dale, David Hargreaves, Roland Meighan, Ivan Reid and Graham Vulliamy (Banks et al. 1980, 4) that appeared in its first issue, and set out its remit. The seven scholars who wrote that editorial pledged to "publish high quality work of any…

  9. The Aims of Education and the Leap of Freedom

    ERIC Educational Resources Information Center

    Yun, SunInn

    2014-01-01

    This paper considers the place of freedom in discussions of the aims of education. Bearing in mind remarks of R.S. Peters to the affect that the singling out of aims can "fall into the hands of rationalistically minded curriculum planners", it begins by considering the views of Roland Reichenbach regarding Bildung and his account of this…

  10. Some Thoughts on "Cultural Variation and Dominance in a Globalised Knowledge-Economy"

    ERIC Educational Resources Information Center

    Yang, Yang; Gentry, Marcia

    2012-01-01

    To view giftedness research in a global context is an important and desirable attempt. Roland S. Persson (2012a), in the target article entitled Cultural Variation and Dominance in a Globalised Knowledge-Economy: Towards a Cultural-Sensitive Research Paradigm in the Science of Giftedness, delivers thought-provoking views in the cultural influences…

  11. The Proper Place of Theory in Educational History?

    ERIC Educational Resources Information Center

    Urban, Wayne J.

    2011-01-01

    In this article, the author talks about the proper place of theory in educational history and shares his comments on the essays by Eileen Tamura, Carolyn Eick, and Roland Coloma. Eileen Tamura's positing of most educational historians as practitioners of narrative history is surely on the mark. She invites historians of education to investigate…

  12. A Catalyst for Charting a Path to Research Validity in the Field of Gifted Education

    ERIC Educational Resources Information Center

    Sisk, Dorothy A.

    2012-01-01

    Roland S. Persson's (2012a) article addresses a concern that many educators have stressed in their theoretical models, namely the importance of the interaction between the individual and the environment, and the impact of culture on not only values and beliefs, but on behaviour. As Persson (2012a) points out these models all have merit, but he…

  13. 1967: The Birth of "The Death of the Author"

    ERIC Educational Resources Information Center

    Logie, John

    2013-01-01

    Roland Barthes's "The Death of the Author" is a foundational text for scholars who are addressing questions of authorship and textual ownership in English studies and its neighboring disciplines. Barthes's essay is typically presented without significant attention to the circumstances and context surrounding its initial English publication in 1967…

  14. Goals and Objectives of National Science Policy. Science Policy Study--Hearings Volume 1. Hearings before the Task Force on Science Policy of the Committee on Science and Technology, House of Representatives, Ninety-Ninth Congress, First Session (February 28; March 7, 21, 28; April 4, 1985). No. 46.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Science and Technology.

    These hearings, which focused on the goals and objectives of national science policy, include discussions, questions and answers for the record, and, when applicable, prepared statements. Individuals appearing during the hearings include: (1) George C. Pimentel; (2) Alex Roland; (3) John S. Foster, Jr.; (4) James B. Wyngaarden; and (5) Lewis M.…

  15. Wallace Stevens: A Collection of Critical Essays. Twentieth Century Views Series.

    ERIC Educational Resources Information Center

    Borroff, Marie, Ed.

    One of a series of works aimed at presenting contemporary critical opinion on major authors, this collection includes essays by Marie Borroff, Wallace Stevens, Joseph N. Riddle, Hi Simons, Sister M. Bernetta Quinn, C. Roland Wagner, Harold Bloom, Ralph J. Mills, Jr., Roy Harvey Pearce, Louis L. Martz, Morton Dauwen Zabel, and Northrop Frye--all…

  16. The Myth in the Discourse.

    ERIC Educational Resources Information Center

    Breen, Myles; Corcoran, Farrel

    Reflecting the ideas of Roland Barthes, this paper examines the nature and importance of myth as a type of speech. The investigation proceeds by discussing myth from the perspectives of both traditional and contemporary disciplines, then considers the universality of myth, its religious impulse, and its functions. Using examples from television…

  17. Keys to Success

    ERIC Educational Resources Information Center

    Viadero, Debra

    2004-01-01

    This article discusses how Roland G. Tharp and his colleagues from the Center for Research on Education, Diversity, & Excellence, a federal research center at the University of California, identify methods to help "nonmainstream" pupils make academic gains. Tharp has identified five standards that he says mark effective instruction in classrooms…

  18. 78 FR 23522 - Idaho Roadless Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ...Pursuant to 36 CFR 294.27 the Forest Service, U.S. Department of Agriculture (USDA), is proposing to modify Idaho Roadless Area boundaries for the Big Creek, Grandmother Mountain, Pinchot Butte, Roland Point, Wonderful Peak Idaho Roadless Areas on the Idaho Panhandle National Forests to reflect lands acquired within and/or adjacent to these roadless areas. In addition, modifications to correct......

  19. Planning and Implementing Augmentative Communication Service Delivery, 2: Proceedings of the National Planners Conference on Assistive Device Service Delivery.

    ERIC Educational Resources Information Center

    Coston, Caroline A., Ed.

    The document consists of 30 author contributed chapters concerned with augmentative communication service delivery. Chapter titles and authors are: "Communication Options for Persons Who Cannot Speak: Planning for Service Delivery" (David Beukelman); "Planning Service Delivery Systems" (Roland Hahn II); "Planning Ohio's Augmentative Communication…

  20. On Universals, Cultural Variations and Individual Uniqueness: Throwing down the Gauntlet in Giftedness Research

    ERIC Educational Resources Information Center

    Garces-Bacsal, Rhoda Myra

    2012-01-01

    Roland S. Persson's (2012a) piece is extremely comprehensive, timely and very relevant especially in light of a growing appreciation of cultural diversity and the emergence of a global community--which is an inevitable offshoot of globalisation that goes beyond world economy and international markets. It covers multiple themes; ranging from…

  1. The Time Is Ripe (Again)

    ERIC Educational Resources Information Center

    Barth, Roland S.

    2013-01-01

    "It's always been a promising time for teacher leadership. It's just never been a successful time," writes noted educator Roland Barth. Why? Barth points to five obstacles: administrator resistance, the taboo in teaching against elevating oneself higher than one's peers, the fact that teachers' plates are full, the…

  2. 76 FR 19765 - Toutant Hydropower Inc.; Notice of Application Accepted for Filing, Soliciting Comments, Motions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-08

    ... Energy Regulatory Commission Toutant Hydropower Inc.; Notice of Application Accepted for Filing... Hydropower Inc. e. Name of Project: M.S.C. (Toutant) Hydroelectric Project. f. Location: The project is..., 16 U.S.C. 791a-825r. h. Applicant Contact: Roland Toutant, Toutant Hydropower, Inc., 80 Bungay...

  3. Philosophy, Children and Liberal Education.

    ERIC Educational Resources Information Center

    Reed, T. M.; Hanna, Patricia

    1981-01-01

    Remarks directed to Peter Augustine Lawler and an earlier article are presented. The rationale for a program of philosophy for children developed at Montclair State College is compared with Roland Garrett's conception of philosophy. Distortions in Lawler's perception of current philosophical practice and teaching are indicated. (MLW)

  4. Constructing an Ethical Writer for the Postmodern Scene.

    ERIC Educational Resources Information Center

    Hassett, Michael J.

    The advent of postmodern criticism has brought about numerous changes in the way those in the academy read and teach the reading of texts. From Michel Foucault's "What is an Author?" to Roland Barthes'"The Death of the Author" and beyond, critics and theorists have sought to decrease the author-ity of the material that is read. In doing so, these…

  5. Benign Childhood Focal Epilepsies: Assessment of Established and Newly Recognized Syndromes

    ERIC Educational Resources Information Center

    Panayiotopoulos, Chrysostomos P.; Michael, Michael; Sanders, Sue; Valeta, Thalia; Koutroumanidis, Michael

    2008-01-01

    A big advance in epileptology has been the recognition of syndromes with distinct aetiology, clinical and EEG features, treatment and prognosis. A prime and common example of this is rolandic epilepsy that is well known by the general paediatricians for over 50 years, thus allowing a precise diagnosis that predicts an excellent prognosis. However,…

  6. Black Superintendents of Selected American Cities.

    ERIC Educational Resources Information Center

    Negro History Bulletin, 1980

    1980-01-01

    Presents photographs of 12 Black superintendents of urban school districts. They are: J. Jerome Harris, Ronald Lewis, Willie W. Herenton, Robert R. Wheeler, Alonzo A. Crim, Roland N. Patterson, Jean Franklin Emmons, Charles R. Thomas, Richard C. Hunter, Arthur Jefferson, Ulysses Byas, and Howard E. White, Sr. (GC)

  7. The Scenic Route Is Not Always the Most Informative

    ERIC Educational Resources Information Center

    Freeman, Joan

    2012-01-01

    Roland S. Persson's (2012a) argument is that there is a dominant research culture in the field of gifts and talents, which must of necessity distort research and practice in cultures which are different. He ties this to the dominance of the global economy and points to the need for more cross-cultural studies. In this commentary, the author points…

  8. The Role of the State and the Social Partners: Mechanisms and Spheres of Influence.

    ERIC Educational Resources Information Center

    Vocational Training, 1992

    1992-01-01

    This serial issue is devoted to clarifying the attitudes of the various parties or "social partners" to vocational training in the Member States of the European Community. Following an editorial introducing the topic are these articles: "The Community Social Dialogue" (Roland Tavitian); "From the Market Jungle to the Social Dialogue: Vocational…

  9. European Consciousness: Towards Defining a Complex Concept and Its Educational Significance (Europaisches Bewusstsein: Zur Definition Eines Vielschichtigen Begriffes und Seiner Bildungstheoretischen Bedeutung)

    ERIC Educational Resources Information Center

    Jobst, Solvejg

    2005-01-01

    The present study aims at a definition of "European consciousness". In particular, it draws on Henri Tajfel's theory of social identity as well as Roland Wakenhut's and Jutta Gallenmuller's moral determination of national consciousness. European consciousness is then defined as a sense of belonging which, depending on certain identification…

  10. No Child Left Behind and the Spectacle of Failing Schools: The Mythology of Contemporary School Reform

    ERIC Educational Resources Information Center

    Granger, David A.

    2008-01-01

    This article discusses what David Berliner (2005) has called the perverse "spectacle of fear" (208) surrounding issues of teacher quality and accountability in contemporary school reform. Drawing principally on the critical semiotics of Roland Barthes' essay, "The World of Wrestling" (1957), it examines the way that this spectacle works to…

  11. Literary Theory and the Notion of Difficulty. Report Series 4.7.

    ERIC Educational Resources Information Center

    Touponce, William

    The works of French literary theorists Jacques Lacan, Jacques Derrida, and Roland Barthes reflect a view of the text as the primary object of investigation for any discipline in the human sciences. Each of the three has been involved with pedagogical reforms within French cultural institutions: Derrida with the teaching of philosophy, Lacan with…

  12. Empire: An Analytical Category for Educational Research

    ERIC Educational Resources Information Center

    Coloma, Roland Sintos

    2013-01-01

    In this article Roland Sintos Coloma argues for the relevance of empire as an analytical category in educational research. He points out the silence in mainstream studies of education on the subject of empire, the various interpretive approaches to deploying empire as an analytic, and the importance of indigeneity in research on empire and…

  13. What's Foucault Got to Do with It? History, Theory, and Becoming Subjected

    ERIC Educational Resources Information Center

    Butchart, Ronald E.

    2011-01-01

    The three essays that make up this issue on theory in educational history by Eileen Tamura, Caroline Eick, and Roland Sintos Coloma constitute an indictment of the field of the history of education for its neglect of theory. Read linearly, from the Introduction through Coloma, the indictment becomes increasingly strident, moving from a gentle call…

  14. 41 CFR 50-201.2 - Administration of the Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 10 of the Portal-to-Portal Act of 1947 (61 Stat. 84, 29 U.S.C. 251, et seq., discussed in 29 CFR part.... (“Skidmore v. Swift & Co.”, 323 U.S. 134 (1944), “Roland Co. v. Walling”, 326 U.S. 657 (1946);...

  15. 41 CFR 50-201.2 - Administration of the Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 10 of the Portal-to-Portal Act of 1947 (61 Stat. 84, 29 U.S.C. 251, et seq., discussed in 29 CFR part.... (“Skidmore v. Swift & Co.”, 323 U.S. 134 (1944), “Roland Co. v. Walling”, 326 U.S. 657 (1946);...

  16. 41 CFR 50-201.2 - Administration of the Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 10 of the Portal-to-Portal Act of 1947 (61 Stat. 84, 29 U.S.C. 251, et seq., discussed in 29 CFR part.... (“Skidmore v. Swift & Co.”, 323 U.S. 134 (1944), “Roland Co. v. Walling”, 326 U.S. 657 (1946);...

  17. 29 CFR 4.101 - Official rulings and interpretations in this subpart.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... incorrect. See for example, Skidmore v. Swift & Co., 323 U.S. 134 (1944); Roland Co. v. Walling, 326 U.S... responsibilities of administration and enforcement (Skidmore v. Swift & Co., 323 U.S. 134 (1944)). In order that... informed judgment to which courts and litigants may properly resort for guidance” (Skidmore v. Swift &...

  18. 41 CFR 50-201.2 - Administration of the Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 10 of the Portal-to-Portal Act of 1947 (61 Stat. 84, 29 U.S.C. 251, et seq., discussed in 29 CFR part.... (“Skidmore v. Swift & Co.”, 323 U.S. 134 (1944), “Roland Co. v. Walling”, 326 U.S. 657 (1946);...

  19. 29 CFR 4.101 - Official rulings and interpretations in this subpart.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... incorrect. See for example, Skidmore v. Swift & Co., 323 U.S. 134 (1944); Roland Co. v. Walling, 326 U.S... responsibilities of administration and enforcement (Skidmore v. Swift & Co., 323 U.S. 134 (1944)). In order that... informed judgment to which courts and litigants may properly resort for guidance” (Skidmore v. Swift &...

  20. 41 CFR 50-201.2 - Administration of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 10 of the Portal-to-Portal Act of 1947 (61 Stat. 84, 29 U.S.C. 251, et seq., discussed in 29 CFR part.... (“Skidmore v. Swift & Co.”, 323 U.S. 134 (1944), “Roland Co. v. Walling”, 326 U.S. 657 (1946);...

  1. 29 CFR 4.101 - Official rulings and interpretations in this subpart.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... incorrect. See for example, Skidmore v. Swift & Co., 323 U.S. 134 (1944); Roland Co. v. Walling, 326 U.S... responsibilities of administration and enforcement (Skidmore v. Swift & Co., 323 U.S. 134 (1944)). In order that... informed judgment to which courts and litigants may properly resort for guidance” (Skidmore v. Swift &...

  2. 29 CFR 4.101 - Official rulings and interpretations in this subpart.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... incorrect. See for example, Skidmore v. Swift & Co., 323 U.S. 134 (1944); Roland Co. v. Walling, 326 U.S... responsibilities of administration and enforcement (Skidmore v. Swift & Co., 323 U.S. 134 (1944)). In order that... informed judgment to which courts and litigants may properly resort for guidance” (Skidmore v. Swift &...

  3. The Cenozoic Diversity of Agglutinated Foraminifera - Evidence for a late Oligocene to early Miocene diversification event

    NASA Astrophysics Data System (ADS)

    Kaminski, Michael; Setoyama, Eiichi; Kender, Sev; Cetean, Claudia

    2014-05-01

    The agglutinated foraminifera are among the most abundant micro-organisms in the deep marine environment and have a diversity record extending back to the late Precambrian. We present an updated diversity curve for agglutinated foraminiferal genera based on the stratigraphic ranges of all the agglutinated genera recognized as valid in the classification of Kaminski (2014). The data set for this analysis is based on the stratigraphic ranges of agglutinated genera published in Foraminiferal Genera and their Classification, which has been subsequently updated based on published studies and our new observations. The mean standing diversity of agglutinated foraminiferal genera was compiled by counting the number of boundary crossers rather than the number of genera in each stage. In this study, we report the stratigraphic and geographical occurrence of a benthic foraminiferal diversification event that has previously received little attention. In the latest Oligocene to earliest Miocene a number of trochospiral agglutinated genera with alveolar or canaliculate walls first appeared in the fossil record. Our studies of late Oligocene of the Congo fan, offshore Angola (Kender et al., 2008; Cetean and Kaminski, 2011) have revealed a diverse assemblage that includes new taxa of deep-water agglutinated foraminifera. In a biostratigraphic study of the Miocene foraminiferal assemblages Kender et al. (2008) noted steadily increasing diversity and proportions of infaunal agglutinated foraminiferal morphotypes over the lower Miocene interval. The proportion of infaunal agglutinated foraminifera assigned to the order Textularida increased dramatically in the lower mid-Miocene, suggesting expansion of the oxygen minimum zone into deeper waters. In addition to the trochospiral alveolar genera, several species of Reticulophragmium and Cyclammina display rapid diversification into numerous separate lineages that are at present not reflected in our generic diversity record owing to

  4. Session: Reservoir Technology

    SciTech Connect

    Renner, Joel L.; Bodvarsson, Gudmundur S.; Wannamaker, Philip E.; Horne, Roland N.; Shook, G. Michael

    1992-01-01

    This session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of five papers: ''Reservoir Technology'' by Joel L. Renner; ''LBL Research on the Geysers: Conceptual Models, Simulation and Monitoring Studies'' by Gudmundur S. Bodvarsson; ''Geothermal Geophysical Research in Electrical Methods at UURI'' by Philip E. Wannamaker; ''Optimizing Reinjection Strategy at Palinpinon, Philippines Based on Chloride Data'' by Roland N. Horne; ''TETRAD Reservoir Simulation'' by G. Michael Shook

  5. The Cortical Connectivity of the Prefrontal Cortex in the Monkey Brain

    PubMed Central

    Yeterian, Edward H.; Pandya, Deepak N.; Tomaiuolo, Francesco; Petrides, Michael

    2011-01-01

    One dimension of understanding the functions of the prefrontal cortex is knowledge of cortical connectivity. We have surveyed three aspects of prefrontal cortical connections: local projections (within the frontal lobe), the termination patterns of long association (post-Rolandic) projections, and the trajectories of major fiber pathways. The local connections appear to be organized in relation to dorsal (hippocampal origin) and ventral (paleocortical origin) architectonic trends. According to the proposal of a dual origin of the cerebral cortex, cortical areas can be traced as originating from archicortex (hippocampus) on the one hand, and paleocortex, on the other hand, in a stepwise manner (e.g., Sanides, 1969; Pandya and Yeterian, 1985). Prefrontal areas within each trend are connected with less architectonically differentiated areas, and, on the other hand, with more differentiated areas. Such organization may allow for the systematic exchange of information within each architectonic trend. The long connections of the prefrontal cortex with post-Rolandic regions seem to be organized preferentially in relation to dorsal and ventral prefrontal architectonic trends. Prefrontal areas are connected with post-Rolandic auditory, visual and somatosensory association areas, and with multimodal and paralimbic regions. This long connectivity likely works in conjunction with local connections to serve prefrontal cortical functions. The afferent and efferent connections of the prefrontal cortex with post-Rolandic regions are conveyed by specific long association pathways. These pathways as well appear to be organized in relation to dorsal and ventral prefrontal architectonic trends. Finally, although prefrontal areas have preferential connections in relation to dual architectonic trends, it is clear that there are interconnections between and among areas in each trend, which may provide a substrate for the overall integrative function of the prefrontal cortex. Prefrontal

  6. Atypical "benign" partial epilepsy of childhood or pseudo-lennox syndrome. Part II: family study.

    PubMed

    Doose, H; Hahn, A; Neubauer, B A; Pistohl, J; Stephani, U

    2001-02-01

    Atypical benign partial epilepsy of childhood (ABPE = Pseudo-Lennox syndrome) shows semiologic parallels to Lennox-Gastaut syndrome, however--besides the lack of tonic seizures--it has an entirely different etiology and prognosis. Recently Hahn et al [17] investigated the long-term evolution of 43 cases with ABPE. Symptomatology, EEG findings, and course were found to overlap with Rolandic epilepsy, Landau-Kleffner syndrome and ESES. The incidence of seizures in relatives was determined in the whole series investigated by Hahn et al [17]. Five of 56 siblings suffered from seizures (3 Rolandic seizures; one febrile convulsions; one unclassified). Three fathers reported grand mal. In 29 families of the series of Hahn et al EEG recordings were performed: 22 brothers, 19 sisters and 16 pairs of parents. In 29% of the siblings a sharp wave focus was demonstrable. The rate rose to 40% when only siblings investigated at the age of maximum expression (3 to 10 years) were considered. Sharp wave foci were mostly multifocal and indistinguishable from those observed in siblings of children with Rolandic epilepsy. Photoparoxysmal response and generalized spikes and waves during rest and hyperventilation were also found to be significantly elevated (26% and 13% respectively). We conclude that ABPE is a subgroup of idiopathic partial epilepsy of childhood (representing a less benign part of a spectrum) that has to be ranked in a continuum with Rolandic epilepsy. The different clinical phenotype might be caused by a higher expressivity of the identical genetic trait, possibly facilitated by other genetic or acquired factors. Genetic heterogeneity represents another possibility. PMID:11315204

  7. 737 Windshear Tests, Orlando

    NASA Technical Reports Server (NTRS)

    1992-01-01

    NASA researchers evaluating wind shear sensor displays in the experimental flight deck at NASA's Boeing 737 research aircraft. During this flight test program, over 75 microbursts were penetrated at altitudes from 800-1100 ft to test the performance of radar, lidar and infrared wind shear sensors. Pictured from left to right are Wind Shear Program Manager Roland Bowles, NASA research pilot Lee Person, Wind Shear Program Deputy Manager Michael Lewis, NASA research engineer David Hinton, NASA research engineer Emedio Bracalante.

  8. Fireworks under the microscope: a spectacular new species of Zodiomyces from the Thaxter collection.

    PubMed

    Rossi, Walter; Haelewaters, Danny; Pfister, Donald H

    2016-01-01

    A new species of Zodiomyces (Ascomycota, Laboulbeniales) is described, Z. rhizophorus, parasitic on a hydrophilid beetle (Coleoptera, Hydrophilidae) from Trinidad. This species was discovered during the examination of the slides of Laboulbeniales made by Roland Thaxter. It is characterized by numerous long, slender, multicellular and multiseriate outgrowths at the base of the receptacle. Thaxter's outstanding illustrations have set a standard in the field of mycology; we provide a review of the methods he employed in the preparation of these illustrations. PMID:27055574

  9. Data-Based Methods for AB Initio Protein Structure Prediction

    SciTech Connect

    Dr Keith L. Frost

    2002-11-07

    OAK 270 - Per the DOE Project Officer ''Roland Hirsh'' Germantown, Md. The required final report for this award has been waived due to the fact Dr Keith Frost who was the P.I. on the research took a leave of absence at the end of March 2000, and left the university without an approval. The University adjusted their records to reflect this early termination; no further funding applied.

  10. Effect of white matter disease on functional connections in the aging brain.

    PubMed Central

    Leuchter, A F; Dunkin, J J; Lufkin, R B; Anzai, Y; Cook, I A; Newton, T F

    1994-01-01

    Periventricular white matter hyperintensities (PVHs) seen on T2 weighted MRI studies are common in elderly people and often represent demyelination of fibres. Damage to these fibres could lead to functional disconnection between brain regions. Electroencephalographic coherence, a measure of shared electrical activity between regions, was examined to determine if there was evidence for such disconnection. Twenty two subjects with clinically diagnosed dementia of the Alzheimer's type, 16 with multi-infarct dementia, and 18 normal controls were studied. It was hypothesised that coherence between areas presumably linked by fibres that traverse the periventricular region would be decreased in subjects with PVHs, and that PVHs would have a stronger association with decreased coherence than clinical diagnosis. It was also hypothesised that coherence between areas presumably connected by long corticocortical tracts that are neuroanatomically separated from the ventricles would be low in patients with Alzheimer's disease because of pyramidal cell death in this group, but would not be affected by the presence of PVHs. Patients with PVHs in fact had lower coherence than those without PVHs in the pre-Rolandic and post-Rolandic areas, where connecting fibres traverse the periventricular region. There was no effect of PVHs, however, on coherence between areas separated by the Rolandic fissure that were connected by long corticocortical tracts; this coherence was lowest among the patients with Alzheimer's disease. These patterns of association suggest that coherence may detect different types of neurophysiological "disconnection," and may be sensitive to selective damage to different fibre pathways. Images PMID:7964810

  11. Language and central temporal auditory processing in childhood epilepsies.

    PubMed

    Boscariol, Mirela; Casali, Raquel L; Amaral, M Isabel R; Lunardi, Luciane L; Matas, Carla G; Collela-Santos, M Francisca; Guerreiro, Marilisa M

    2015-12-01

    Because of the relationship between rolandic, temporoparietal, and centrotemporal areas and language and auditory processing, the aim of this study was to investigate language and central temporal auditory processing of children with epilepsy (rolandic epilepsy and temporal lobe epilepsy) and compare these with those of children without epilepsy. Thirty-five children aged between eight and 14 years old were studied. Two groups of children participated in this study: a group with childhood epilepsy (n=19), and a control group without epilepsy or linguistic changes (n=16). There was a significant difference between the two groups, with the worst performance in children with epilepsy for the gaps-in-noise test, right ear (p<0.001) and left ear (p<0.001) tests, and duration pattern test--naming (p=0.002) and humming (p=0.002). In auditory P300, there was no significant difference in latency (p=0.343) and amplitude (p=0.194) between the groups. There was a significant difference between the groups, with the worst performance in children with epilepsy, for the auditory-receptive vocabulary (PPVT) (p<0.001) and phonological working memory (nonwords repetition task) tasks (p=0.001). We conclude that the impairment of central temporal auditory processing and language skills may be comorbidities in children with rolandic epilepsy and temporal lobe epilepsy. PMID:26580215

  12. Positron computed tomography studies of cerebral metabolic responses to complex motor tasks

    SciTech Connect

    Phelps, M.E.; Mazziotta, J.C.

    1984-01-01

    Human motor system organization was explored in 8 right-handed male subjects using /sup 18/F-fluorodeoxyglucose and positron computed tomography to measure cerebral glucose metabolism. Five subjects had triple studies (eyes closed) including: control (hold pen in right hand without moving), normal size writing (subject repeatedly writes name) and large (10-15 X normal) name writing. In these studies normal and large size writing had a similar distribution of metabolic responses when compared to control studies. Activations (percent change from control) were in the range of 12-20% and occurred in the striatum bilaterally > contralateral Rolandic cortex > contralateral thalamus. No significant activations were observed in the ipsilateral thalamus, Rolandic cortex or cerebellum (supplementary motor cortex was not examined). The magnitude of the metabolic response in the striatum was greater with the large versus normal sized writing. This differential response may be due to an increased number and topographic distribution of neurons responding with the same average activity between tasks or an increase in the functional activity of the same neuronal population between the two tasks (present spatial resolution inadequate to differentiate). When subjects (N=3) performed novel sequential finger movements, the maximal metabolic response was in the contralateral Rolandic cortex > striatum. Such studies provide a means of exploring human motor system organization, motor learning and provide a basis for examining patients with motor system disorders.

  13. Brain activity varies with modulation of dynamic pitch variance in sentence melody.

    PubMed

    Meyer, Martin; Steinhauer, Karsten; Alter, Kai; Friederici, Angela D; von Cramon, D Yves

    2004-05-01

    Fourteen native speakers of German heard normal sentences, sentences which were either lacking dynamic pitch variation (flattened speech), or comprised of intonation contour exclusively (degraded speech). Participants were to listen carefully to the sentences and to perform a rehearsal task. Passive listening to flattened speech compared to normal speech produced strong brain responses in right cortical areas, particularly in the posterior superior temporal gyrus (pSTG). Passive listening to degraded speech compared to either normal or flattened speech particularly involved fronto-opercular and subcortical (Putamen, Caudate Nucleus) regions bilaterally. Additionally the Rolandic operculum (premotor cortex) in the right hemisphere subserved processing of neat sentence intonation. As a function of explicit rehearsing sentence intonation we found several activation foci in the left inferior frontal gyrus (Broca's area), the left inferior precentral sulcus, and the left Rolandic fissure. The data allow several suggestions: First, both flattened and degraded speech evoked differential brain responses in the pSTG, particularly in the planum temporale (PT) bilaterally indicating that this region mediates integration of slowly and rapidly changing acoustic cues during comprehension of spoken language. Second, the bilateral circuit active whilst participants receive degraded speech reflects general effort allocation. Third, the differential finding for passive perception and explicit rehearsal of intonation contour suggests a right fronto-lateral network for processing and a left fronto-lateral network for producing prosodic information. Finally, it appears that brain areas which subserve speech (frontal operculum) and premotor functions (Rolandic operculum) coincidently support the processing of intonation contour in spoken sentence comprehension. PMID:15068910

  14. Who Pioneered the Use of Antipsychotics in North America?

    PubMed Central

    Stip, Emmanuel

    2015-01-01

    Objective: Neuroleptics were introduced into North America 60 years ago. The credit for this advance is generally accorded to Heinz Lehmann. I sought to explore whether Lehmann really was the first North American psychiatrist to study the effects of chlorpromazine (CPZ) and to provide a more balanced view of its application in a clinical context. Method: I searched for historical documents and published articles in several libraries and interviewed psychiatrists active from 1952–1970. Results: The first article in English was published in the July volume of the Archives of Neurology and Psychiatry in 1954 (n = 71). Another article, written in French by Roland Saucier and published in a journal called Le Saguenay Médical, also described the effects of CPZ on a Canadian psychiatric population in August 1954 (n > 200). However, the first prescription for CPZ was written by Roland Saucier, who brought the product back from Paris after a fellowship there. Ruth Kajander, in Ontario, was also one of the first prescribers of this drug, following her study of its use in anesthesia and a publication in the proceedings of a symposium. Conclusion: The contents of the 2 naturalistic studies were compared. Lehmann’s study started 1 month before that of Saucier. Lehmann was the first North American psychiatrist to publish an article on CPZ, but Roland Saucier nevertheless made an important contribution, being the first to prescribe this drug in North America and reporting results for a study with a sample size 3 times that of Lehmann’s study. PMID:25886681

  15. Astronomy-Connected Scientific Works in Early Transylvania and Banat

    NASA Astrophysics Data System (ADS)

    Farkas, Ladislau

    2008-09-01

    Baron Roland von Eötvös: physicist who demonstrated the proportionality of the inertial and gravitational mass and carried out research on the spatial changes in gravitation. Some of his experiments was made on the territory of Banat and Crisana (south-easter Transylvania). Count Luigi Ferdinando Marsigli: a very complex personality: engineer, diplomat, spy, scientist (geograph, historian, biologist, astronomer), who made the first astronomical observations in Banat and published them. Maximilian Hell: a mathematician and astronomer who founded the first astronomical observatory in Cluj and made observations on a very interesting natural phenomenon: the transit of the planet Venus.

  16. On the nature of the anti-tail of Comet Kohoutek /1973f/. I - A working model

    NASA Technical Reports Server (NTRS)

    Sekanina, Z.

    1974-01-01

    The model derived for the anti-tail of Comet Kohoutek describes it as a flat formation, confined essentially to the comet's orbit plane and composed of relatively heavy particles (mostly in the size range 0.1-1 mm) whose motions are controlled by solar gravity and solar radiation pressure. Almost all the material was produced by the comet before perihelion at a rate about an order of magnitude higher than for Comets Arend-Roland and Bennett. The latent heat of vaporization of the particle material is estimated at 40-45 kcal/mole or higher.

  17. Galaxy Velocity Dispersions Using a Cross-Correlation Method: Erratum

    NASA Astrophysics Data System (ADS)

    Dalle Ore, Cristina; Faber, S. M.; Gonzalez, J. Jesus; Stoughton, Roland; Burstein, David

    1991-07-01

    In the paper "Galaxy Velocity Dispersions Using a Cross-Correlation Method" by Cristina Dalle Ore, S. M. Faber, J. Jesus Gonzalez, Roland Stoughton, and David Burstein (ApJ, 366,38 [1991]), the following corrections should be made: 1. The full name of the third author is J. Jesus Gonzalez. 2. The last line of equation (3) should read: [(t x t)*v|d], instead of [(t x t) * v|]. 3. Line 7 of the second paragraph on page 40 should read "...matches the observed FWHM of t x g. Equation (3) is more..."

  18. Evaluation of Clear Sky Models for Satellite-Based Irradiance Estimates

    SciTech Connect

    Sengupta, M.; Gotseff, P.

    2013-12-01

    This report describes an intercomparison of three popular broadband clear sky solar irradiance model results with measured data, as well as satellite-based model clear sky results compared to measured clear sky data. The authors conclude that one of the popular clear sky models (the Bird clear sky model developed by Richard Bird and Roland Hulstrom) could serve as a more accurate replacement for current satellite-model clear sky estimations. Additionally, the analysis of the model results with respect to model input parameters indicates that rather than climatological, annual, or monthly mean input data, higher-time-resolution input parameters improve the general clear sky model performance.

  19. A quasi-Newton acceleration for high-dimensional optimization algorithms

    PubMed Central

    Alexander, David; Lange, Kenneth

    2010-01-01

    In many statistical problems, maximum likelihood estimation by an EM or MM algorithm suffers from excruciatingly slow convergence. This tendency limits the application of these algorithms to modern high-dimensional problems in data mining, genomics, and imaging. Unfortunately, most existing acceleration techniques are ill-suited to complicated models involving large numbers of parameters. The squared iterative methods (SQUAREM) recently proposed by Varadhan and Roland constitute one notable exception. This paper presents a new quasi-Newton acceleration scheme that requires only modest increments in computation per iteration and overall storage and rivals or surpasses the performance of SQUAREM on several representative test problems. PMID:21359052

  20. Molecules and Clusters in Intense Laser Fields

    NASA Astrophysics Data System (ADS)

    Posthumus, Jan

    2009-09-01

    Preface; 1. Ultra-high intensity based on Ti:Sapphire Philip F. Taday and Andrew J. Langley; 2. Diatomic molecules in intense laser fields Jan H. Posthumus and James F. McCann; 3. Small polyatomic molecules in intense laser fields C. Cornaggia; 4. Coherent control in intense laser fields Eric Charron and Brian Sheehy; 5. Experimental studies of laser-heated rare gas clusters M. Lezius and M. Schmidt; 6. Single cluster explosions and high harmonic generation John W. G. Tisch and Emma Springate; 7. Intense laser interaction with extended cluster media Roland A. Smith and Todd Ditmire.

  1. Molecules and Clusters in Intense Laser Fields

    NASA Astrophysics Data System (ADS)

    Posthumus, Jan

    2001-06-01

    Preface; 1. Ultra-high intensity based on Ti:Sapphire Philip F. Taday and Andrew J. Langley; 2. Diatomic molecules in intense laser fields Jan H. Posthumus and James F. McCann; 3. Small polyatomic molecules in intense laser fields C. Cornaggia; 4. Coherent control in intense laser fields Eric Charron and Brian Sheehy; 5. Experimental studies of laser-heated rare gas clusters M. Lezius and M. Schmidt; 6. Single cluster explosions and high harmonic generation John W. G. Tisch and Emma Springate; 7. Intense laser interaction with extended cluster media Roland A. Smith and Todd Ditmire.

  2. Air resistance measurements on actual airplane parts

    NASA Technical Reports Server (NTRS)

    Weiselsberger, C

    1923-01-01

    For the calculation of the parasite resistance of an airplane, a knowledge of the resistance of the individual structural and accessory parts is necessary. The most reliable basis for this is given by tests with actual airplane parts at airspeeds which occur in practice. The data given here relate to the landing gear of a Siemanms-Schuckert DI airplane; the landing gear of a 'Luftfahrzeug-Gesellschaft' airplane (type Roland Dlla); landing gear of a 'Flugzeugbau Friedrichshafen' G airplane; a machine gun, and the exhaust manifold of a 269 HP engine.

  3. The European Micropaleontological Reference Centre in Kraków

    NASA Astrophysics Data System (ADS)

    Kaminski, Michael; Waskowska, Anna; Bebenek, Slawomir; Pilarz, Monika

    2016-04-01

    We are pleased to announce the establishment of the European Micropaleontological Reference Centre, housed in the offices of Micropress Europe at the AGH University of Science & Technology in Krakow, Poland. The new European Micropaleontological Reference Centre is an initiative of the Grzybowski Foundation and Micropress Europe. The centre is designed to serve the micropaleontological community by providing a permanent repository or "museum" for published microfossil collections. The centre houses a growing collection of microfossils picked into faunal slides, as well as a well-stocked library of micropaleontological books, journals, and reprints. We have the only up-to-date paper copy of the Ellis & Messina Catalogue of Foraminifera in Central Europe. Currently, the slide collections include: - Type slides of benthic foraminifera from Poland (the collection of I. Heller from the Polish oil company GEONAFTA), - Carboniferous foraminifera from Germany and Poland (collections of G. Eickhoff and Z. Alexandrowicz), - IODP sites in the Arctic, Atlantic, and Indian Oceans (collections of M. Kaminski, E. Setoyama, A. Holborn), - Exploration wells in the Boreal seas: North Sea, Norwegian Sea, Western Barents Sea, Labrador Sea, Bering Sea, Spitsbergen, Western Siberia (collections of M. Kaminski, J. Nagy, T. Van Den Akker, V. Podobina, and others), - Paratethyan Foraminifera (collections of E. Luczkowska, C. Beldean, F. Szekely), - Mesozoic-Paleogene Foraminifera from Gubbio, Italy (collections of M. Kaminski, C. Cetean, and students) and the Polish Carpathians (collection of A. Waskowska), - Caribbean (collection of M. Kaminski, R. Preece), West Africa (collection of R. Preece, S. Kender, C. Cetean), - We have a separate collection of type specimens of species (paratypes). Slides are housed in cabinet drawers together with the relevant publication. Researchers are welcome to visit the offices of Micropress Europe to view the archived microfossil collections. The center

  4. Cortical gamma-oscillations modulated by visuomotor tasks -Intracranial recording in patients with epilepsy-

    PubMed Central

    Nagasawa, Tetsuro; Rothermel, Robert; Juhász, Csaba; Nishida, Masaaki; Sood, Sandeep; Asano, Eishi

    2010-01-01

    SUMMARY We determined how visuomotor tasks modulated gamma-oscillations on electrocorticography in epileptic patients who underwent epilepsy surgery. Each visual-cue consisted of either a sentence or hand gesture instructing the subject to press or not to press the button. Regardless of the recorded hemisphere, viewing sentence and gesture cues elicited gamma-augmentation sequentially in the lateral-polar occipital and inferior occipital-temporal areas; subsequently, button-press movement elicited gamma-augmentation in the Rolandic area. The magnitudes of gamma-augmentation in the Rolandic and inferior occipital-temporal areas were larger when the hand contralateral to the recorded hemisphere was used for motor responses. A double dissociation was found in the left inferior occipital-temporal cortex in one subject; the lateral portion had greater gamma-augmentation elicited by a sentence-cue, whereas the medial portion had greater gamma-augmentation elicited by a gesture-cue. The present study has increased our understanding of the physiology of the human visuomotor system. PMID:20580900

  5. Disrupted White Matter Network and Cognitive Decline in Type 2 Diabetes Patients.

    PubMed

    Zhang, Junying; Liu, Zhen; Li, Zixiao; Wang, Yunxia; Chen, Yaojing; Li, Xin; Chen, Kewei; Shu, Ni; Zhang, Zhanjun

    2016-05-01

    Type 2 diabetes mellitus is accompanied by cognitive impairment and is associated with an increased risk of dementia. Damage to brain structures such as white matter network disruption may underlie this cognitive disturbance. In the present study, 886 non-diabetic and 163 type 2 diabetic participants completed a battery of neuropsychological tests. Among them, 38 diabetic patients and 34 non-diabetic participants that matched the patients for age/sex/education received a magnetic resonance imaging-based diffusion tensor imaging. Then we calculated the topological properties of the white matter network using a graph theoretical method to investigate network efficiency differences between groups. We found that type 2 diabetic patients had inferior performances compared to the non-diabetic controls, in several cognitive domains involving executive function, spatial processing, memory, and attention. We also found that diabetic patients exhibited a disrupted topological organization of the white matter network (including the global network properties, i.e., network strength, global efficiency, local efficiency and shortest path length, and the nodal efficiency of the right rolandic operculum) in the brain. Moreover, those global network properties and the nodal efficiency of the right rolandic operculum both had positive correlations with executive function in the patient group. The results suggest that type 2 diabetes mellitus leads to an alteration in the topological organization of the cortical white matter network and this alteration may account for the observed cognitive decline. PMID:27163818

  6. Probing of structural relaxation times in the glassy state of sucrose and trehalose based on dynamical properties of two secondary relaxation processes

    SciTech Connect

    Kaminski, K.; Adrjanowicz, K.; Paluch, M.; Kaminska, E.

    2011-06-15

    Time-dependent isothermal dielectric measurements were carried out deeply in the glassy state on two very important saccharides: sucrose and trehalose. In both compounds two prominent secondary relaxation processes were identified. The faster one is an inherent feature of the whole family of carbohydrates. The slower one can also be detected in oligo- and polysaccharides. It was shown earlier that the {beta} process is the Johari-Goldstein (JG) relaxation coupled to motions of the glycosidic linkage, while the {gamma} relaxation originates from motions of the exocyclic hydroxymethyl unit. Recently, it was shown that the JG relaxation process can be used to determine structural relaxation times in the glassy state [R. Casalini and C. M. Roland, Phys. Rev. Lett. 102, 035701 (2009)]. In this paper we present the results of an analysis of the data obtained during aging using two independent approaches. The first was proposed by Casalini and Roland, and the second one is based on the variation of the dielectric strength of the secondary relaxation process during aging [J. K. Vij and G. Power, J. Non-Cryst. Solids 357, 783 (2011)]. Surprisingly, we found that the estimated structural relaxation times in the glassy state of both saccharides are almost the same, independent of the type of secondary mode. This finding calls into question the common view that secondary modes of intramolecular origin do not provide information about the dynamics of the glassy state.

  7. Can clinical and radiological findings predict surgery for lumbar disc herniation? A systematic literature review

    PubMed Central

    White, Andrew P.; Harrop, James; Dettori, Joseph R.

    2012-01-01

    Study design: Systematic review. Objective or clinical question: What clinical and radiological findings in patients with lumbar-herniated nucleus pulposus can serve as predictors of surgical intervention? Methods: Articles published between January 1975 and August 2011 were systematically reviewed using Pubmed, Cochrane, National Guideline Clearinghouse Databases, and bibliographies of key articles. Each article was subject to quality rating and was analyzed by two independent reviewers. Results: From 123 citations, 21 underwent full-text review. Four studies met inclusion criteria. Only baseline disability as measured by the Roland Disability Index (RDI) or the Oswestry Disability Index (ODI) was consistently associated with a greater likelihood of having discectomy surgery across multiple studies. With the current literature, we were not able to find an association between surgery and several characteristics including smoking status, body mass index, neurological deficit, positive straight leg testing, and level of herniation. Conclusions: From the limited data available, it appears that individual radiographic and clinical features are not able to predict the likelihood of surgical intervention. Higher baseline disability measurements (Oswestry and Roland) did correlate, however, with surgical treatment. PMID:23236305

  8. Epidemiological study of low back pain and occupational risk factors among taxi drivers.

    PubMed

    Miyamoto, Masabumi; Konno, Shunsuke; Gembun, Yoshikazu; Liu, Xinyu; Minami, Kazufumi; Ito, Hiromoto

    2008-04-01

    A survey of taxi drivers was conducted to determine the actual situation of drivers' low back pain (LBP). The survey was carried out in October 2002, the target drivers were asked to complete a questionnaire which contains questions regarding physique of drivers, demographic features, working conditions, office environment, health conditions, the presence of low back pain, the level of low back pain based on Visual Analogue Scale and Roland-Morris Disability Questionnaire score. As a result, the total number of valid responses was 1,334 and the response rate was 71 percent, and the 1-wk prevalence of LBP was 20.5 percent of respondents. Regarding 275 subjects with LBP, Visual Analogue Scale (VAS) averaged 4.3. There was a positive weak correlation between VAS and Roland-Morris Disability Questionnaire score (R=0.41). And Logistic regression analysis was performed to examine the relationship between LBP and occupational factors, the results suggested following items as risk factors; such as history of LBP, suffering from fatigue, diseases other than LBP and smoking habit. PMID:18413963

  9. An fMRI Study of Obesity, Food Reward, and Perceived Caloric Density: Does a Low-Fat Label Make Food Less Appealing?

    PubMed Central

    Ng, Janet; Stice, Eric; Yokum, Sonja; Bohon, Cara

    2011-01-01

    We tested the hypothesis that obese individuals experience greater activation of the gustatory and somatosensory cortex, but weaker activation of the striatum, in response to intake and anticipated intake of high-fat chocolate milkshake versus an isocaloric milkshake labeled low-fat and a tasteless solution using functional magnetic resonance imaging (fMRI) with 17 obese and 17 lean young women. Obese relative to lean women showed greater activation in somatosensory (Rolandic operculum), gustatory (frontal operculum), and reward valuation regions (amgydala, ventralmedial prefrontal cortex (vmPFC) in response to intake and anticipated intake of milkshake versus tasteless solution, though there was little evidence of reduced striatal activation. Obese relative to lean women also showed greater activation in the Rolandic operculum, frontal operculum, and vmPFC in response to isocaloric milkshakes labeled regular versus lowfat. Results suggest that hyper-responsivity of somatosensory, gustatory, and reward valuation regions may be related to overeating and that top-down processing influence reward encoding, which could further contribute to weight gain. PMID:21497628

  10. Sensorimotor activation related to speaker vs. listener role during natural conversation

    PubMed Central

    Mandel, Anne; Bourguignon, Mathieu; Parkkonen, Lauri; Hari, Riitta

    2016-01-01

    Although the main function of speech is communication, the brain bases of speaking and listening are typically studied in single subjects, leaving unsettled how brain function supports interactive vocal exchange. Here we used whole-scalp magnetoencephalography (MEG) to monitor modulation of sensorimotor brain rhythms related to the speaker vs. listener roles during natural conversation. Nine dyads of healthy adults were recruited. The partners of a dyad were engaged in live conversations via an audio link while their brain activity was measured simultaneously in two separate MEG laboratories. The levels of ∼10-Hz and ∼20-Hz rolandic oscillations depended on the speaker vs. listener role. In the left rolandic cortex, these oscillations were consistently (by ∼20%) weaker during speaking than listening. At the turn changes in conversation, the level of the ∼10 Hz oscillations enhanced transiently around 1.0 or 2.3 s before the end of the partner’s turn. Our findings indicate left-hemisphere-dominant involvement of the sensorimotor cortex during own speech in natural conversation. The ∼10-Hz modulations could be related to preparation for starting one’s own turn, already before the partner’s turn has finished. PMID:26742643

  11. Dysfunction of the Heteromeric KV7.3/KV7.5 Potassium Channel is Associated with Autism Spectrum Disorders

    PubMed Central

    Gilling, Mette; Rasmussen, Hanne B.; Calloe, Kirstine; Sequeira, Ana F.; Baretto, Marta; Oliveira, Guiomar; Almeida, Joana; Lauritsen, Marlene B.; Ullmann, Reinhard; Boonen, Susanne E.; Brondum-Nielsen, Karen; Kalscheuer, Vera M.; Tümer, Zeynep; Vicente, Astrid M.; Schmitt, Nicole; Tommerup, Niels

    2012-01-01

    Heterozygous mutations in the KCNQ3 gene on chromosome 8q24 encoding the voltage-gated potassium channel KV7.3 subunit have previously been associated with rolandic epilepsy and idiopathic generalized epilepsy (IGE) including benign neonatal convulsions. We identified a de novo t(3;8) (q21;q24) translocation truncating KCNQ3 in a boy with childhood autism. In addition, we identified a c.1720C > T [p.P574S] nucleotide change in three unrelated individuals with childhood autism and no history of convulsions. This nucleotide change was previously reported in patients with rolandic epilepsy or IGE and has now been annotated as a very rare SNP (rs74582884) in dbSNP. The p.P574S KV7.3 variant significantly reduced potassium current amplitude in Xenopus laevis oocytes when co-expressed with KV7.5 but not with KV7.2 or KV7.4. The nucleotide change did not affect trafficking of heteromeric mutant KV7.3/2, KV7.3/4, or KV7.3/5 channels in HEK 293 cells or primary rat hippocampal neurons. Our results suggest that dysfunction of the heteromeric KV7.3/5 channel is implicated in the pathogenesis of some forms of autism spectrum disorders, epilepsy, and possibly other psychiatric disorders and therefore, KCNQ3 and KCNQ5 are suggested as candidate genes for these disorders. PMID:23596459

  12. Spatial alexia.

    PubMed

    Ardila, A; Rosselli, M

    1994-05-01

    Twenty-one patients with right hemisphere damage were studied (11 men, 10 women; average age = 41.33; range = 19-65). Patients were divided in two groups: pre-Rolandic (six patients) and retro-Rolandic (15 patients) right hemisphere damage. A special reading test was given to each patient. The observed errors included: literal errors (substitutions, additions, and omissions of letters), substitutions of syllables and pseudowords for meaningful words, left hemispatial neglect, confabulation, splitting of words, verbal errors (substitutions, additions, and omission of words), grouping of letters belonging to two different words, misuse of punctuation marks, and errors in following lines. It was proposed that spatial alexia is characterized by: (1) some difficulties in the recognition of the spatial orientation in letters; (2) left hemispatial neglect; (3) tendency to "complete" the sense of words and sentences; (4) inability to follow lines when reading texts, and sequentially explore the spatial distribution of the written material; and (5) grouping and fragmentation of words, most likely as a consequence of the inability to interpret the relative value of spaces between letters correctly. PMID:7960468

  13. Voxel-Wise Meta-Analysis of Gray Matter Changes in Amyotrophic Lateral Sclerosis

    PubMed Central

    Shen, Dongchao; Cui, Liying; Fang, Jia; Cui, Bo; Li, Dawei; Tai, Hongfei

    2016-01-01

    Background: Increasing neuroimaging studies have revealed gray matter (GM) anomalies of several brain regions by voxel-based morphometry (VBM) studies in patients with amyotrophic lateral sclerosis (ALS). A voxel-wise meta-analysis was conducted to integrate the reported studies to determine the consistent GM alterations in ALS based on VBM methods. Methods: Ovid Medline, Pubmed, Emabase, and BrainMap database were searched for relevant studies.Data were extracted by two independent researchers. Voxel-wise meta-analysis was performed using the effect-size signed differential mapping (ES-SDM) software. Results: Twenty-nine VBM studies comprising 638 subjects with ALS and 622 healthy controls (HCs) met inclusion criteria.The global GM volumes of ALS patients were significantly decreased compared with those of HCs. GM reductions in patients were mainly located in the right precentral gyrus, the left Rolandic operculum, the left lenticular nucleus and the right anterior cingulate/paracingulate gyri. The right precentral gyrus and the left inferior frontal gyrus might be potential anatomical biomarkers to evaluate the severity of the disease, and longer disease duration was associated with more GM atrophy in the left frontal aslant tract and the right precentral gyrus in ALS patients. Conclusion: The results support that ALS is a complex degenerative disease involving multisystems besides the motor system.The mechanism of asymmetric atrophy of the motor cortex and the implication of Rolandic operculum involvement in ALS need to be further elucidated in future studies. PMID:27065078

  14. And to end on a poetic note: Galen’s authorial strategies in the pharmacological books

    PubMed Central

    Totelin, Laurence M.V.

    2012-01-01

    This paper examines the authorial strategies deployed by Galen in his two main pharmacological treatises devoted to compound remedies: Composition of Medicines according to Types and Composition of Medicines according to Places. Some of Galen’s methods of self assertion (use of the first person; writing of prefaces) are conventional. Others have not received much attention from scholars. Thus, here, I examine Galen’s borrowing of his sources’ ‘I’; his use of the phrase ‘in these words’; and his recourse to Damocrates’ verse to conclude pharmacological books. I argue that Galen’s authorial persona is very different from that of the modern author as defined by Roland Barthes. Galen imitates and impersonates his pharmacological sources. This re-enactment becomes a way to gain experience (peira) of remedies and guarantees their efficacy.

  15. Airborne Wind Shear Detection and Warning Systems. Second Combined Manufacturers' and Technologists' Conference, part 2

    NASA Technical Reports Server (NTRS)

    Spady, Amos A., Jr. (Compiler); Bowles, Roland L. (Compiler); Schlickenmaier, Herbert (Compiler)

    1990-01-01

    The Second Combined Manufacturers' and Technologists' Conference was hosted jointly by NASA Langley (LaRC) and the Federal Aviation Administration (FAA) in Williamsburg, Virginia, on October 18 to 20, 1988. The meeting was co-chaired by Dr. Roland Bowles of LaRC and Herbrt Schlickenmaier of the FAA. The purpose of the meeting was to transfer significant, ongoing results gained during the second year of the joint NASA/FAA Airborne Wind Shear Program to the technical industry and to pose problems of current concern to the combined group. It also provided a forum for manufacturers to review forward-look technology concepts and for technologists to gain an understanding of the problems encountered by the manufacturers during the development of airborne equipment and the FAA certification requirements.

  16. Benign nocturnal alternating hemiplegia of childhood: two cases with positive evolution.

    PubMed

    Villéga, Frédéric; Picard, Fabienne; Espil-Taris, Caroline; Husson, Marie; Michel, Véronique; Pedespan, Jean-Michel

    2011-06-01

    Benign nocturnal alternating hemiplegia (BNAH) of childhood is distinct from the classic form of malignant alternating hemiplegia of childhood [1]. It is characterized by hemiplegic attacks occurring exclusively during sleep [2]. It can be misdiagnosed as migraine, nocturnal frontal lobe epilepsy, benign rolandic epilepsy, Panayiotopoulos syndrome, or sleep-related movement disorder [1-4]. Only nine patients have been described to date, with typically, a normal development [1,5-7]. In order to insist about the benignity of the affection, we report two cases: a new three-year-old boy suffering from BNAH and a patient already published to show positive evolution at fourteen years of age. BNAH is a rare disorder but may be underdiagnosed. Making an early diagnosis can help to describe to the parents the good prognosis without treatment. PMID:20817433

  17. Historical photogrammetry: Bird's Paluxy River dinosaur chase sequence digitally reconstructed as it was prior to excavation 70 years ago.

    PubMed

    Falkingham, Peter L; Bates, Karl T; Farlow, James O

    2014-01-01

    It is inevitable that some important specimens will become lost or damaged over time, conservation is therefore of vital importance. The Paluxy River dinosaur tracksite is among the most famous in the world. In 1940, Roland T. Bird described and excavated a portion of the site containing associated theropod and sauropod trackways. This excavated trackway was split up and housed in different institutions, and during the process a portion was lost or destroyed. We applied photogrammetric techniques to photographs taken by Bird over 70 years ago, before the trackway was removed, to digitally reconstruct the site as it was prior to excavation. The 3D digital model offers the opportunity to corroborate maps drawn by R.T. Bird when the tracksite was first described. More broadly, this work demonstrates the exciting potential for digitally recreating palaeontological, geological, or archaeological specimens that have been lost to science, but for which photographic documentation exists. PMID:24695537

  18. Five benefits of call recording for medical practices.

    PubMed

    Murphy, Roland

    2010-01-01

    Despite documentation's essential positioning in medical practices of all sizes and specialties, one aspect of patient and insurance provider interaction remains overlooked in the majority of practices: telephone-based communication. In many cases, patient and payment information exchanged via telephone is logged with little more than a note typed or written in the patient file. This leads to "he said/she said" disagreements with regard to patient service, consultations, and coding; reduced payments from insurance providers; incomplete patient records; liability exposure; and a host of other problems. In this article, call recording professional Roland Murphy explains how a call recording solution can fill the gaps in documentation, increase practice revenues, and improve patient care without excessive investment costs and while protecting patient confidentiality. PMID:20480782

  19. Historical Photogrammetry: Bird's Paluxy River Dinosaur Chase Sequence Digitally Reconstructed as It Was prior to Excavation 70 Years Ago

    PubMed Central

    Falkingham, Peter L.; Bates, Karl T.; Farlow, James O.

    2014-01-01

    It is inevitable that some important specimens will become lost or damaged over time, conservation is therefore of vital importance. The Paluxy River dinosaur tracksite is among the most famous in the world. In 1940, Roland T. Bird described and excavated a portion of the site containing associated theropod and sauropod trackways. This excavated trackway was split up and housed in different institutions, and during the process a portion was lost or destroyed. We applied photogrammetric techniques to photographs taken by Bird over 70 years ago, before the trackway was removed, to digitally reconstruct the site as it was prior to excavation. The 3D digital model offers the opportunity to corroborate maps drawn by R.T. Bird when the tracksite was first described. More broadly, this work demonstrates the exciting potential for digitally recreating palaeontological, geological, or archaeological specimens that have been lost to science, but for which photographic documentation exists. PMID:24695537

  20. International Program and Local Organizing Committees

    NASA Astrophysics Data System (ADS)

    2012-12-01

    International Program Committee Dionisio Bermejo (Spain) Roman Ciurylo (Poland) Elisabeth Dalimier (France) Alexander Devdariani (Russia) Milan S Dimitrijevic (Serbia) Robert Gamache (USA) Marco A Gigosos (Spain) Motoshi Goto (Japan) Magnus Gustafsson (Sweden) Jean-Michel Hartmann (France) Carlos Iglesias (USA) John Kielkopf (USA) John C Lewis (Canada) Valery Lisitsa (Russia) Eugene Oks (USA) Christian G Parigger (USA) Gillian Peach (UK) Adriana Predoi-Cross (Canada) Roland Stamm (Germany) Local Organizing Committee Nikolay G Skvortsov (Chair, St Petersburg State University) Evgenii B Aleksandrov (Ioffe Physico-Technical Institute, St Petersburg) Vadim A Alekseev (Scientific Secretary, St Petersburg State University) Sergey F Boureiko (St.Petersburg State University) Yury N Gnedin (Pulkovo Observatory, St Petersburg) Alexander Z Devdariani (Deputy Chair, St Petersburg State University) Alexander P Kouzov (Deputy Chair, St Petersburg State University) Nikolay A Timofeev (St Petersburg State University)

  1. The acute effect of music on interictal epileptiform discharges.

    PubMed

    Turner, Robert P

    2004-10-01

    This study was a prospective, randomized, single-blinded, crossover, placebo-controlled, pilot clinical trial investigating the effect of Mozart's Sonata for Two Pianos (K448) on the frequency of interictal epileptiform discharges (IEDs) from the EEGs of children with benign childhood epilepsy with centrotemporal spikes, or "rolandic" epilepsy. The goal was to demonstrate decreased frequency of IEDs with exposure to K448. Four subjects were recruited and 4-hour awake EEG recordings performed. IED frequency per minute was averaged over each of three epochs per hour. Mean IED count per epoch, standard deviations, and variance were calculated. Only complete waking epochs were analyzed. Two subjects demonstrated sufficient waking IEDs for statistical analysis, consisting of three epochs of K448-related effects. Significant decreases in IEDs per minute (33.7, 50.6, and 33.9%) were demonstrated comparing baseline with exposure to K448, but not to control music (Beethoven's Für Elise). PMID:15380117

  2. Langevin Simulation of Microstructure in Martensitic Transformations

    NASA Astrophysics Data System (ADS)

    Wu, Y.; Lookman, T.; Shenoy, S. R.; Saxena, A.; Bishop, A. R.

    1996-03-01

    We present a dynamical model to simulate microstructure in martensitic transformations within the context of shape memory alloys. The Hamiltonian of the system includes a triple-well potential (φ^6 model) in local shear strain, (2) strain gradient terms up to second order in strain and fourth order in gradient, and (3) all symmetry allowed compositional fluctuation induced strain gradient terms. We show the formation of twinned martensite below the transformation temperature and tweed precursors above the transformation temperature, as well as indications of hierarchical structures near the habit plane. These phases result from a competition between short range attraction and long range elastic repulsive forces. The long range interaction is incorporated via Fourier spectral methods as discussed by C. Roland and R.C.Desai [Phys. Rev. B 42, 6658 (1990)].

  3. Position specificity in Chitonomyces (Ascomycota, Laboulbeniomycetes) on Laccophilus (Coleoptera, Dytiscidae): a molecular approach resolves a century-old debate.

    PubMed

    Goldmann, Lauren; Weir, Alex

    2012-01-01

    The occurrence of Laboulbeniomycete species consistently on a precise portion of beetle integument was investigated in 13 species of Chitonomyces ectoparasitic on the aquatic diving beetle Laccophilus maculosus (Coleoptera, Dytiscidae). The phenomenon was called "position specificity" by Roland Thaxter in 1896, yet the mechanism has remained unknown. By using molecular analysis of the nucSSU rRNA gene and the 5.8S and partial ITS1 rRNA regions, 13 species of Chitonomyces reported to exhibit position specificity on Laccophilus maculosus were placed neatly into pairs of morphotypes, resulting in synonomies and recognition of six phylogenetic species (one species is a triplet). Each phylogenetic species was located at corresponding positions on male and female beetles that make contact during mating. In addition, ecological data and video footage of the mating behaviors of Laccophilus confirmed that sexual transmission is the mechanism behind this enigmatic phenomenon. PMID:22684291

  4. Session: Program Review X Wrap-Up

    SciTech Connect

    1992-01-01

    This wrap-up session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of Closing Remarks by Roland R. Kessler and six NGA Industry Critique Panel presentations: ''Summary of Comments on DOE-Industry Cooperation by Geothermal Industry Panel'' by James B. Koenig, GeothermEx, Inc.; ''NGA Industry Critique of the Exploration Component'' by Joe L. Iovenitti, Weiss Associates; ''Critique of Drilling Research'' by Jerry Hamblin, UNOCAL Geothermal; ''Critique Panel Comments on Reservoir Engineering, DOE Geothermal Technology Development'' by Dennis Kaspereit, California Energy Company, Inc.; ''DOE Geothermal Program Review - Critique on Production'' by Douglas B. Jung, Two-Phase Engineering and Research; ''Comments on the DOE Hydrothermal Energy Conversion R&D Program'' by David L. Mendive, Geothermal Development Associates.

  5. An Apparently Classical Case Report of Sturge-Weber Syndrome.

    PubMed

    Giannantoni, Nadia Mariagrazia; Della Marca, Giacomo; Vollono, Catello

    2015-10-01

    Sturge-Weber syndrome is a rare, sporadic, congenital neurocutaneous syndrome, likely due to abnormal development of the cephalic microvasculature. Symptoms and signs depend on the extent and location of the venous dysplasia. We describe a case of a 33-year-old woman presenting with drug-resistant epilepsy, chronic headache, and recurring nonepileptic seizures. Computed tomography and magnetic resonance imaging scans showed severe frontoparietal right hemisphere atrophy, prevalent right frontoparietal leptomeningeal enhancement, circumscribed angioma of the left rolandic sulcus, and prominent deep venous system. We report an apparently classical Sturge-Weber syndrome and hypothesize a shared pathophysiologic mechanism for clinical symptoms. We speculate that all the main symptoms observed in our patient could be the expression of a functional imbalance between the atrophic right hemisphere and the hyperexcitable left cortex. PMID:25392004

  6. [Adélaïde Hautval (1906-1988): An exemplary medical personality].

    PubMed

    Halioua, Bruno; Hauptmann, Georges

    2015-12-01

    Adélaïde Hautval (1906-1988), psychiatrist, was arrested in April 1942 having defended a Jewish family abused by German soldiers. She was imprisoned in Bourges and in several camps in France (Pithiviers, Beaune-la-Rolande, Orléans, Romainville) before being deported as a "Friend of the Jews" at Auschwitz in the convoy of 23 January 1943, said 31,000 convoy with 229 other resistant women, Marie-Claude Vaillant-Couturier, Charlotte Delbo, Danielle Casanova. She refused to participate in the "medical" experience of Nazi doctors Clauberg, Schumann, Wirths and Mengele at Birkenau. She was then deported to Ravensbrück. During her deportation, she illustrated her dedication in the medical management of the deportees. She testified repeatedly on her experience of remote doctor. Hautval Adélaïde was the first French woman doctor named Righteous among the Nations in 1965. PMID:26411305

  7. At Home in the Universe

    NASA Astrophysics Data System (ADS)

    Wheeler, John A.

    Colleague and confidant of Einstein and Bohr and pioneer of nuclear fission -- John A. Wheeler is one of our most original and profound thinkers. In engaging essays formed of reminiscence, science, and conjecture, Wheeler writes of debates and discussions with Bohr, long talks with Einstein in his study at Princeton, and the eloquence and nobility of Hermann Weyl. With simple delight in "the machinery of existence" Wheeler exudes an enthusiasm that illuminates this collection. John Wheeler is one of the 20th century's most notable nuclear physicists and relativity theorists. In addition, he has played a leading role in research on pulsars, black holes, and nuclear reactor safety. Dr. Wheeler is Jan and Roland Blumberg Professor Emeritus at the University of Texas, Austin and Joseph Henry Professor of Physics Emeritus at Princeton University.

  8. [Verbal auditory agnosia: SPECT study of the brain].

    PubMed

    Carmona, C; Casado, I; Fernández-Rojas, J; Garín, J; Rayo, J I

    1995-01-01

    Verbal auditory agnosia are rare in clinical practice. Clinically, it characterized by impairment of comprehension and repetition of speech but reading, writing, and spontaneous speech are preserved. So it is distinguished from generalized auditory agnosia by the preserved ability to recognize non verbal sounds. We present the clinical picture of a forty-years-old, right handed woman who developed verbal auditory agnosic after an bilateral temporal ischemic infarcts due to atrial fibrillation by dilated cardiomyopathie. Neurophysiological studies by pure tone threshold audiometry: brainstem auditory evoked potentials and cortical auditory evoked potentials showed sparing of peripheral hearing and intact auditory pathway in brainstem but impaired cortical responses. Cranial CT-SCAN revealed two large hypodenses area involving both cortico-subcortical temporal lobes. Cerebral SPECT using 99mTc-HMPAO as radiotracer showed hypoperfusion just posterior in both frontal lobes nect to Roland's fissure and at level of bitemporal lobes just anterior to Sylvian's fissure. PMID:8556589

  9. Hydrodynamic simulations of microjetting from shock-loaded grooves

    NASA Astrophysics Data System (ADS)

    Roland, Caroline; de Resseguier, Thibaut; Sollier, Arnaud; Lescoute, Emilien; Soulard, Laurent; Loison, Didier

    2015-06-01

    The interaction of a shock wave with a free surface presenting geometrical defects, such as cavities or grooves, may lead to the ejection of micrometric debris at velocities of km/s order. This process can be involved in many applications, like pyrotechnics or industrial safety. Laser shock experiments reported in this conference (T. de Resseguier, C. Roland et al., abstract ref.000066) provide insight into jet formation and peak velocities for various groove angles and shock pressures. Here, we present hydrodynamic simulations of these experiments, in both 2D and 3D geometries, using both finite element method and smoothed particles hydrodynamics. Numerical results are compared to several theoretical predictions including the Richtmyer-Meshkov instabilities. The role of the elastic-plastic behavior on jet formation is investigated. Finally, the possibility to simulate the late stages of jet expansion and fragmentation is explored, to evaluate the mass distribution of the ejecta and their ballistic properties, still essentially unknown in the experiments.

  10. Airborne Wind Shear Detection and Warning Systems. Fourth Combined Manufacturers' and Technologists' Conference, part 2

    NASA Technical Reports Server (NTRS)

    Vicroy, Dan D. (Compiler); Bowles, Roland L. (Compiler); Passman, Robert H. (Compiler)

    1992-01-01

    The Fourth Combined Manufacturers' and Technologists' Conference was hosted jointly by NASA Langley Research Center (LaRC) and the Federal Aviation Administration (FAA) in Williamsburg, Virginia, on April 14-16, 1992. The meeting was co-chaired by Dr. Roland Bowles of LaRC and Bob Passman of the FAA. The purpose of the meeting was to transfer significant ongoing results of the NASA/FAA Joint Airborne Wind Shear Program to the technical industry and to pose problems of current concern to the combined group. It also provided a forum for manufacturers to review forward-look technology concepts and for technologists to gain an understanding of the problems encountered by the manufacturers during the development of airborne equipment and the FAA certification requirements. The present document has been compiled to record the essence of the technology updates and discussions which follow each.

  11. Neural mechanisms underlying auditory feedback control of speech

    PubMed Central

    Reilly, Kevin J.; Guenther, Frank H.

    2013-01-01

    The neural substrates underlying auditory feedback control of speech were investigated using a combination of functional magnetic resonance imaging (fMRI) and computational modeling. Neural responses were measured while subjects spoke monosyllabic words under two conditions: (i) normal auditory feedback of their speech, and (ii) auditory feedback in which the first formant frequency of their speech was unexpectedly shifted in real time. Acoustic measurements showed compensation to the shift within approximately 135 ms of onset. Neuroimaging revealed increased activity in bilateral superior temporal cortex during shifted feedback, indicative of neurons coding mismatches between expected and actual auditory signals, as well as right prefrontal and Rolandic cortical activity. Structural equation modeling revealed increased influence of bilateral auditory cortical areas on right frontal areas during shifted speech, indicating that projections from auditory error cells in posterior superior temporal cortex to motor correction cells in right frontal cortex mediate auditory feedback control of speech. PMID:18035557

  12. Cognitive Expertise: An ALE Meta-Analysis.

    PubMed

    Neumann, Nicola; Lotze, Martin; Eickhoff, Simon B

    2016-01-01

    Expert performance constitutes the endpoint of skill acquisition and is accompanied by widespread neuroplastic changes. To reveal common mechanisms of reorganization associated with long-term expertise in a cognitive domain (mental calculation, chess, language, memory, music without motor involvement), we used activation likelihood estimation meta-analysis and compared brain activation of experts to nonexperts. Twenty-six studies matched inclusion criteria, most of which reported an increase and not a decrease of activation foci in experts. Increased activation occurred in the left rolandic operculum (OP 4) and left primary auditory cortex and in bilateral premotor cortex in studies that used auditory stimulation. In studies with visual stimulation, experts showed enhanced activation in the right inferior parietal cortex (area PGp) and the right lingual gyrus. Experts' brain activation patterns seem to be characterized by enhanced or additional activity in domain-specific primary, association, and motor structures, confirming that learning is localized and very specialized. PMID:26467981

  13. Benign idiopathic partial epilepsy and brain lesion.

    PubMed

    Stephani, U; Doose, H

    1999-03-01

    A 14-year-old girl had severe head trauma from a dog bite at the age of 9 days. This resulted in extensive brain damage, tetraplegia, mental retardation, and epilepsy. The seizures were of rolandic type, and the EEG showed multifocal sharp waves. The course was benign. The initial diagnosis of a pure symptomatic epilepsy was revised after demonstrating typical benign focal sharp waves in the EEG of the healthy sister. Thus a phenocopy of a benign partial epilepsy by the brain lesion could be excluded with sufficient certainty. This observation allows the conclusion that the genetic disposition underlying the sharp-wave trait characteristic of benign partial epilepsies can be involved also in the pathogenesis of seemingly pure symptomatic epilepsies. EEG studies on siblings of such patients are needed to exclude possible phenocopies. PMID:10080522

  14. The usefulness of ICG video angiography in the surgical treatment of superior cluneal nerve entrapment neuropathy: technical note.

    PubMed

    Kim, Kyongsong; Isu, Toyohiko; Chiba, Yasuhiro; Morimoto, Daijiro; Ohtsubo, Seiji; Kusano, Mitsuo; Kobayashi, Shiro; Morita, Akio

    2013-11-01

    Superior cluneal nerve (SCN) entrapment neuropathy is a known cause of low back pain. Although surgical release at the entrapment point of the osteofibrous orifice is effective, intraoperative identification of the thin SCN in thick fat tissue and confirmation of sufficient decompression are difficult. Intraoperative indocyanine green video angiography (ICG-VA) is simple, clearly demonstrates the vascular flow dynamics, and provides real-time information on vascular patency and flow. The peripheral nerve is supplied from epineurial vessels around the nerve (vasa nervorum), and the authors now present the first ICG-VA documentation of the technique and usefulness of peripheral nerve neurolysis surgery to treat SCN entrapment neuropathy in 16 locally anesthetized patients. Clinical outcomes were assessed with the Roland-Morris Disability Questionnaire before surgery and at the latest follow-up after surgery. Indocyanine green video angiography was useful for identifying the SCN in fat tissue. It showed that the SCN penetrated and was entrapped by the thoracolumbar fascia through the orifice just before crossing over the iliac crest in all patients. The SCN was decompressed by dissection of the fascia from the orifice. Indocyanine green video angiography visualized the SCN and its termination at the entrapment point. After sufficient decompression, the SCN was clearly visualized on ICG-VA images. Low back pain improved significantly, from a preoperative Roland-Morris Questionnaire score of 13.8 to a postoperative score of 1.3 at the last follow-up visit (p < 0.05). The authors suggest that ICG-VA is useful for the inspection of peripheral nerves such as the SCN and helps to identify the SCN and to confirm sufficient decompression at surgery for SCN entrapment. PMID:24053371

  15. Seventeenth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    Ramey, H.J. Jr.; Kruger, P.; Miller, F.G.; Horne, R.N.; Brigham, W.E.; Cook, J.W.

    1992-01-31

    PREFACE The Seventeenth Workshop on Geothermal Reservoir Engineering was held at Stanford University on January 29-31, 1992. There were one hundred sixteen registered participants which equaled the attendance last year. Participants were from seven foreign countries: Italy, Japan, United Kingdom, France, Belgium, Mexico and New Zealand. Performance of many geothermal fields outside the United States was described in the papers. The Workshop Banquet Speaker was Dr. Raffaele Cataldi. Dr. Cataldi gave a talk on the highlights of his geothermal career. The Stanford Geothermal Program Reservoir Engineering Award for Excellence in Development of Geothermal Energy was awarded to Dr. Cataldi. Dr. Frank Miller presented the award at the banquet. Thirty-eight papers were presented at the Workshop with two papers submitted for publication only. Dr. Roland Horne opened the meeting and the key note speaker was J.E. ''Ted'' Mock who discussed the DOE Geothermal R. & D. Program. The talk focused on aiding long-term, cost effective private resource development. Technical papers were organized in twelve sessions concerning: geochemistry, hot dry rock, injection, geysers, modeling, and reservoir mechanics. Session chairmen were major contributors to the program and we thank: Sabodh Garg., Jim Lovekin, Jim Combs, Ben Barker, Marcel Lippmann, Glenn Horton, Steve Enedy, and John Counsil. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank Pat Ota, Ted Sumida, and Terri A. Ramey who also produces the Proceedings Volumes for publication. We owe a great deal of thanks to our students who operate audiovisual equipment and to Francois Groff who coordinated the meeting arrangements for the Workshop. Henry J. Ramey, Jr. Roland N. Horne Frank G. Miller Paul Kruger William E. Brigham Jean W. Cook -vii

  16. Dilatancy Strengthening As a Mechanism for Earthquake Rupture Barriers and Aseismic Creep Transients on Oceanic Transform Faults

    NASA Astrophysics Data System (ADS)

    Liu, Y.; McGuire, J. J.; Behn, M. D.

    2014-12-01

    Ocean bottom seismometer deployments along the Gofar, Quebrada and Discovery transform faults on the East Pacific Rise (EPR) have revealed strong along-strike variation in M6 earthquake rupture extents and earthquake swarm activity. An active-source refraction survey along the ~ 100-km-long western segment of Gofar found a ~ 10-km-long zone of ~ 10-20% P wave velocity reduction, which extends from the surface to the Moho and acted as a "barrier" to previous cycles of M6 ruptures [McGuire et al., 2012; Roland et al., 2012]. The low velocity zone is interpreted to result primarily from enhanced fault zone porosity. That this region appears to behave as a rupture barrier is interesting from a fault frictional point of view because it nucleates intense microseismicity and hence has velocity-weakening (unstable slip) characteristics. In this study, we use a 3D strike-slip fault model with rate-state friction to investigate how the presence of a high-porosity, strong dilatancy zone embedded in a velocity-weakening transform fault could lead to a persistent earthquake rupture barrier. Rate-state frictional parameters are based on experimental results on gabbro gouge under hydrothermal conditions, and constrained by the tomoDD relocation of seismicity on Gofar [Froment et al., 2014]. Our modeling results reproduce the ~ 5 year recurrence interval of M6 earthquakes on two ~ 20-km-long fault segments separated by a ~ 10 km zone with effective dilatancy strengthening. A stronger dilatancy effect leads to a lower seismic coupling coefficient in the barrier zone. The release of energy in the barrier zone is manifested in various forms of aseismic deformation, including postseismic slip and interseismic slow slip events. The modeled slow slip migration speed and equivalent stress drop are comparable to those estimated from earthquake swarms on transform faults [Roland and McGuire, 2009], and suggests that such swarm activity is primarily driven by aseismic transient slip events.

  17. The 27-item Coping Strategies Questionnaire – Revised: Confirmatory factor analysis, reliability and validity in Italian-speaking subjects with chronic pain

    PubMed Central

    Monticone, Marco; Ferrante, Simona; Giorgi, Ines; Galandra, Caterina; Rocca, Barbara; Foti, Calogero

    2014-01-01

    BACKGROUND: Increasing attention is being devoted to cognitive-behavioural measures to improve interventions for chronic pain. OBJECTIVE: To develop an Italian version of the Coping Strategies Questionnaire – Revised (CSQ-R), and to validate it in a study involving 345 Italian subjects with chronic pain. METHODS: The questionnaire was developed following international recommendations. The psychometric analyses included confirmatory factor analysis; reliability, assessed by internal consistency (Cronbach’s alpha) and test-retest reliability (intraclass correlation coefficients); and construct validity, assessed by calculating the correlations between the subscales of the CSQ-R and measures of pain (numerical rating scale), disability (Sickness Impact Profile – Roland Scale), depression (Center for Epidemiological Studies – Depression Scale) and coping (Chronic Pain Coping Inventory) (Pearson’s correlation). RESULTS: Confirmatory factor analysis revealed that the CSQ-R model had an acceptable data-model fit (comparative fit index and normed fit index ≤0.90, root mean square error of approximation ≥0.08). Cronbach’s alpha was satisfactory (CSQ-R 0.914 to 0.961), and the intraclass correlation coefficients were good/excellent (CSQ-R 0.850 to 0.918). As expected, the correlations with the numerical rating scale, Sickness Impact Profile – Roland Scale, Center for Epidemiological Studies – Depression Scale and Chronic Pain Coping Inventory highlighted the adaptive and maladaptive properties of most of the CSQ-R subscales. CONCLUSION: The CSQ-R was successfully translated into Italian. The translation proved to have good factorial structure, and its psychometric properties are similar to those of the original and other adapted versions. Its use is recommended for clinical and research purposes in Italy and abroad. PMID:24761430

  18. Efficacy and safety of tanezumab in the treatment of chronic low back pain.

    PubMed

    Katz, Nathaniel; Borenstein, David G; Birbara, Charles; Bramson, Candace; Nemeth, Mary Anne; Smith, Mike D; Brown, Mark T

    2011-10-01

    Increased nerve growth factor levels are associated with chronic pain conditions, including chronic low back pain (LBP). This study examined safety and analgesic efficacy of tanezumab, a humanized anti-nerve growth factor antibody, in adults with chronic LBP. Patients received intravenous tanezumab 200 μg/kg plus oral placebo (n=88), intravenous placebo plus oral naproxen 500 mg twice a day (n=88), or intravenous placebo plus oral placebo (n=41). Primary outcome was average LBP intensity (aLBPI) at Week 6. Secondary outcomes were proportion of patients with ≥30% or ≥50% reduction in aLBPI, Roland-Morris Disability Questionnaire and Brief Pain Inventory-short form scores, Patients' Global Assessment of LBP, Patients' Global Evaluation of study medication, and rescue medication use. Mean aLBPI change from baseline to Week 6 was greater with tanezumab vs naproxen (P=0.004) and placebo (P<0.001). Greater proportions of patients reported ≥30% and ≥50% reduction in aLBPI with tanezumab vs naproxen (P≤0.013) and placebo (P<0.001), and greater improvements in Roland-Morris Disability Questionnaire (P<0.001) and other secondary outcomes except rescue medication use. Tanezumab was associated with adverse events (AEs) of abnormal peripheral sensation that were generally mild and resolved before study completion; however, there were no serious AEs. Nine patients (4 of whom were tanezumab-treated) discontinued due to AEs. In conclusion, tanezumab resulted in analgesic efficacy that was clinically and statistically superior to placebo and naproxen in patients with chronic LBP. Tanezumab clinical development is on regulatory hold due to AEs in osteoarthritis patients. PMID:21696889

  19. Convolution and non convolution Perfectly Matched Layer techniques optimized at grazing incidence for high-order wave propagation modelling

    NASA Astrophysics Data System (ADS)

    Martin, Roland; Komatitsch, Dimitri; Bruthiaux, Emilien; Gedney, Stephen D.

    2010-05-01

    by 40% in 2D comparing to the GFPML split formulation of [4]. Examples of waves propagating in heterogeneous thin slices in presence of free surface are shown. We also applied this CPML technique to more complex models like poroelastic [5] or viscoelastic [6] media based on a fourth-order staggered finite-difference method. For the two-dimensional Biot poroelastic equations we show its efficiency for both non dissipative and dissipative Biot porous models. For the three-dimensional viscoelastic seismic wave equation, the time marching equations of the standard linear solid mechanisms used do not need to be split and only the memory variables associated with velocity derivatives are stored at each time step. In the case of more than one damping mechanism, we are able to reduce memory storage by more than 70% in the PML regions in 3D simulations compared to split PMLs optimized at grazing incidence. Benchmarks of the CPML technique have been validated in poroelastic or viscoelastic thin mesh slices. These unsplit CPMLs are usually computed based on a second-order finite-difference time scheme. However, in many situations like very long time simulations, it is of interest to increase the accuracy of the method by increasing the order of the time marching and spatial discretizations. The CPML is not able to be increased at high orders because of its convolution formulation. In [7] we study then how to build a new unsplit PML (ADE-PML/Auxiliary Differential Equations PML) that remains optimized at grazing incidence based on a high-order time scheme like the fourth-order Runge-Kutta scheme. At second order in time we demonstrate that CPML and ADE-PML are equivalent. At second or high order discretization in time, explicit and semi-implicit solutions can be obtained with very good accuracy. References [1]Dimitri Komatitsch and Roland Martin. An unsplit convolutional Perfectly Matched Layer improved at grazing incidence for the differential anisotropic elastic wave equation

  20. The SNAP trial: a double blind multi-center randomized controlled trial of a silicon nitride versus a PEEK cage in transforaminal lumbar interbody fusion in patients with symptomatic degenerative lumbar disc disorders: study protocol

    PubMed Central

    2014-01-01

    Background Polyetheretherketone (PEEK) cages have been widely used in the treatment of lumbar degenerative disc disorders, and show good clinical results. Still, complications such as subsidence and migration of the cage are frequently seen. A lack of osteointegration and fibrous tissues surrounding PEEK cages are held responsible. Ceramic implants made of silicon nitride show better biocompatible and osteoconductive qualities, and therefore are expected to lower complication rates and allow for better fusion. Purpose of this study is to show that fusion with the silicon nitride cage produces non-inferior results in outcome of the Roland Morris Disability Questionnaire at all follow-up time points as compared to the same procedure with PEEK cages. Methods/Design This study is designed as a double blind multi-center randomized controlled trial with repeated measures analysis. 100 patients (18–75 years) presenting with symptomatic lumbar degenerative disorders unresponsive to at least 6 months of conservative treatment are included. Patients will be randomly assigned to a PEEK cage or a silicon nitride cage, and will undergo a transforaminal lumbar interbody fusion with pedicle screw fixation. Primary outcome measure is the functional improvement measured by the Roland Morris Disability Questionnaire. Secondary outcome parameters are the VAS leg, VAS back, SF-36, Likert scale, neurological outcome and radiographic assessment of fusion. After 1 year the fusion rate will be measured by radiograms and CT. Follow-up will be continued for 2 years. Patients and clinical observers who will perform the follow-up visits will be blinded for type of cage used during follow-up. Analyses of radiograms and CT will be performed independently by two experienced radiologists. Discussion In this study a PEEK cage will be compared with a silicon nitride cage in the treatment of symptomatic degenerative lumbar disc disorders. To our knowledge, this is the first randomized controlled

  1. Low back pain: what determines functional outcome at six months? An observational study

    PubMed Central

    2010-01-01

    Background The rise in disability due to back pain has been exponential with escalating medical and societal costs. The relative contribution of individual prognostic indicators to the pattern of recovery remains unclear. The objective of this study was to determine the prognostic value of demographic, psychosocial, employment and clinical factors on outcome in patients with low back pain Methods A prospective cohort study with six-month follow-up was undertaken at a multidisciplinary back pain clinic in central London employing physiotherapists, osteopaths, clinical psychologists and physicians, receiving referrals from 123 general practitioners. Over a twelve-month period, 593 consecutive patients referred from general practice with simple low back pain were recruited. A baseline questionnaire was developed to elicit information on potential prognostic variables. The primary outcome measures were change in 24-item Roland Morris disability questionnaire score at six months as a measure of low back related functional disability and the physical functioning scale of the SF-36, adjusted for baseline scores. Results Roland Morris scores improved by 3.8 index points (95% confidence interval 3.23 to 4.32) at six months and SF-36 physical functioning score by 10.7 points (95% confidence interval 8.36 to 12.95). Ten factors were linked to outcome yet in a multiple regression model only two remained predictive. Those with episodic rather than continuous pain were more likely to have recovered at six months (odds ratio 2.64 confidence interval 1.25 to 5.60), while those that classified themselves as non-white were less likely to have recovered (0.41 confidence interval 0.18 to 0.96). Conclusions Analysis controlling for confounding variables, demonstrated that participants showed greater improvement if their episodes of pain during the previous year were short-lived while those with Middle Eastern, North African and Chinese ethnicity demonstrated minimal improvement. The

  2. YOGA FOR CHRONIC LOW BACK PAIN IN A PREDOMINANTLY MINORITY POPULATION: A PILOT RANDOMIZED CONTROLLED TRIAL

    PubMed Central

    Saper, Robert B.; Sherman, Karen J.; Cullum-Dugan, Diana; Davis, Roger B.; Phillips, Russell S.; Culpepper, Larry

    2009-01-01

    Background Several studies suggest yoga may be effective for chronic low back pain; however, trials targeting minorities have not been conducted. Primary Study Objectives Assess the feasibility of studying yoga in a predominantly minority population with chronic low back pain. Collect preliminary data to plan a larger powered study. Study Design Pilot randomized controlled trial. Setting Two community health centers in a racially diverse neighborhood of Boston, Massachusetts. Participants Thirty English-speaking adults (mean age 44 years, 83% female, 83% racial/ethnic minorities; 48% with incomes ≤$30000) with moderate-to-severe chronic low back pain. Interventions Standardized series of weekly hatha yoga classes for 12 weeks compared to a waitlist usual care control. Outcome Measures Feasibility measured by time to complete enrollment, proportion of racial/ethnic minorities enrolled, retention rates, and adverse events. Primary efficacy outcomes were changes from baseline to 12 weeks in pain score (0=no pain to 10=worst possible pain) and back-related function using the modified Roland-Morris Disability Questionnaire (0–23 point scale, higher scores reflect poorer function). Secondary efficacy outcomes were analgesic use, global improvement, and quality of life (SF-36). Results Recruitment took 2 months. Retention rates were 97% at 12 weeks and 77% at 26 weeks. Mean pain scores for yoga decreased from baseline to 12 weeks (6.7 to 4.4) compared to usual care, which decreased from 7.5 to 7.1 (P=.02). Mean Roland scores for yoga decreased from 14.5 to 8.2 compared to usual care, which decreased from 16.1 to 12.5 (P=.28). At 12 weeks, yoga compared to usual care participants reported less analgesic use (13% vs 73%, P=.003), less opiate use (0% vs 33%, P=.04), and greater overall improvement (73% vs 27%, P=.03). There were no differences in SF-36 scores and no serious adverse events. Conclusion A yoga study intervention in a predominantly minority population with

  3. 3D model of radionuclide dispersion in coastal areas with multifraction cohesive and non-cohesive sediments

    NASA Astrophysics Data System (ADS)

    Brovchenko, Igor; Maderich, Vladimir; Jung, Kyung Tae

    2015-04-01

    We developed new radionuclide dispersion model that may be used in coastal areas, rivers and estuaries with non-uniform distribution of suspended and bed sediments both cohesive and non-cohesive types. Model describes radionuclides concentration in dissolved phase in water column, particulated phase on suspended sediments on each sediment class types, bed sediments and pore water. The transfer of activity between the water column and the pore water in the upper layer of the bottom sediment is governed by diffusion processes. The phase exchange between dissolved and particulate radionuclides is written in terms of desorption rate a12 (s-1) and distribution coefficient Kd,iw and Kd,ib (m3/kg) for water column and for bottom deposit, respectively. Following (Periáñez et al., 1996) the dependence of distribution coefficients is inversely proportional to the sediment particle size. For simulation of 3D circulation, turbulent diffusion and wave fields a hydrostatic model SELFE (Roland et. al. 2010) that solves Reynolds-stress averaged Navier-Stokes (RANS) equations and Wave Action transport equation on the unstructured grids was used. Simulation of suspended sediment concentration and bed sediments composition is based on (L. Pinto et. al., 2012) approach that originally was developed for non-cohesive sediments. In present study we modified this approach to include possibility of simulating mixture of cohesive and non-cohesive sediments by implementing parameterizations for erosion and deposition fluxes for cohesive sediments and by implementing flocculation model for determining settling velocity of cohesive flocs. Model of sediment transport was calibrated on measurements in the Yellow Sea which is shallow tidal basin with strongly non-uniform distribution of suspended and bed sediments. Model of radionuclide dispersion was verified on measurements of 137Cs concentration in surface water and bed sediments after Fukushima Daiichi nuclear accident. References Peri

  4. Estimating the number needed to treat from continuous outcomes in randomised controlled trials: methodological challenges and worked example using data from the UK Back Pain Exercise and Manipulation (BEAM) trial

    PubMed Central

    2009-01-01

    Background Reporting numbers needed to treat (NNT) improves interpretability of trial results. It is unusual that continuous outcomes are converted to numbers of individual responders to treatment (i.e., those who reach a particular threshold of change); and deteriorations prevented are only rarely considered. We consider how numbers needed to treat can be derived from continuous outcomes; illustrated with a worked example showing the methods and challenges. Methods We used data from the UK BEAM trial (n = 1, 334) of physical treatments for back pain; originally reported as showing, at best, small to moderate benefits. Participants were randomised to receive 'best care' in general practice, the comparator treatment, or one of three manual and/or exercise treatments: 'best care' plus manipulation, exercise, or manipulation followed by exercise. We used established consensus thresholds for improvement in Roland-Morris disability questionnaire scores at three and twelve months to derive NNTs for improvements and for benefits (improvements gained+deteriorations prevented). Results At three months, NNT estimates ranged from 5.1 (95% CI 3.4 to 10.7) to 9.0 (5.0 to 45.5) for exercise, 5.0 (3.4 to 9.8) to 5.4 (3.8 to 9.9) for manipulation, and 3.3 (2.5 to 4.9) to 4.8 (3.5 to 7.8) for manipulation followed by exercise. Corresponding between-group mean differences in the Roland-Morris disability questionnaire were 1.6 (0.8 to 2.3), 1.4 (0.6 to 2.1), and 1.9 (1.2 to 2.6) points. Conclusion In contrast to small mean differences originally reported, NNTs were small and could be attractive to clinicians, patients, and purchasers. NNTs can aid the interpretation of results of trials using continuous outcomes. Where possible, these should be reported alongside mean differences. Challenges remain in calculating NNTs for some continuous outcomes. Trial Registration UK BEAM trial registration: ISRCTN32683578. PMID:19519911

  5. Sixteenth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    Ramey, H.J. Jr.; Kruger, P.; Miller, F.G.; Horne, R.N.; Brigham, W.E.; Cook, J.W.

    1991-01-25

    The Sixteenth Workshop on Geothermal Reservoir Engineering was held at Stanford University on January 23-25, 1991. The Workshop Banquet Speaker was Dr. Mohinder Gulati of UNOCAL Geothermal. Dr. Gulati gave an inspiring talk on the impact of numerical simulation on development of geothermal energy both in The Geysers and the Philippines. Dr. Gulati was the first recipient of The Stanford Geothermal Program Reservoir Engineering Award for Excellence in Development of Geothermal Energy. Dr. Frank Miller presented the award. The registered attendance figure of one hundred fifteen participants was up slightly from last year. There were seven foreign countries represented: Iceland, Italy, Philippines, Kenya, the United Kingdom, Mexico, and Japan. As last year, papers on about a dozen geothermal fields outside the United States were presented. There were thirty-six papers presented at the Workshop, and two papers were submitted for publication only. Attendees were welcomed by Dr. Khalid Aziz, Chairman of the Petroleum Engineering Department at Stanford. Opening remarks were presented by Dr. Roland Horne, followed by a discussion of the California Energy Commission's Geothermal Activities by Barbara Crowley, Vice Chairman; and J.E. ''Ted'' Mock's presentation of the DOE Geothermal Program: New Emphasis on Industrial Participation. Technical papers were organized in twelve sessions concerning: hot dry rock, geochemistry, tracer injection, field performance, modeling, and chemistry/gas. As in previous workshops, session chairpersons made major contributions to the program. Special thanks are due to Joel Renner, Jeff Tester, Jim Combs, Kathy Enedy, Elwood Baldwin, Sabodh Garg, Marcel0 Lippman, John Counsil, and Eduardo Iglesias. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank Pat Ota, Angharad Jones, Rosalee Benelli, Jeanne Mankinen, Ted Sumida, and Terri A. Ramey who also produces the Proceedings Volumes

  6. Reduction in Pain and Inflammation Associated With Chronic Low Back Pain With the Use of the Medical Food Theramine.

    PubMed

    Shell, William E; Pavlik, Stephanie; Roth, Brandon; Silver, Michael; Breitstein, Mira L; May, Lawrence; Silver, David

    2014-09-18

    Management of chronic back pain is a challenge for physicians. Although standard treatments exert a modest effect, they are associated with narcotic addiction and serious side effects from nonsteroidal antiinflammatory agents. Moreover, neurotransmitter depletion from both the pain syndrome and therapy may contribute to a poor treatment outcome. Neurotransmitter deficiency may be related both to increased turnover rate and inadequate neurotransmitter precursors from the diet, particularly for essential and semi-essential amino acids. Theramine, an amino acid blend 68405-1 (AAB), is a physician-prescribed only medical food. It contains neurotransmitter precursors and systems for increasing production and preventing attenuation of neurotransmitters. A double-blind controlled study of AAB, low-dose ibuprofen, and the coadministration of the 2 agents were performed. The primary end points included the Roland Morris index and Oswestry disability scale. The cohort included 122 patients aged between 18 and 75 years. The patients were randomized to 1 of 3 groups: AAB alone, ibuprofen alone, and the coadministration of the 2 agents. In addition, C-reactive protein, interleukin 6, and plasma amino acid concentrations were measured at baseline and 28 days time points. After treatment, the Oswestry Disability Index worsened by 4.52% in the ibuprofen group, improved 41.91% in the AAB group, and improved 62.15% in the combination group. The Roland Morris Index worsened by 0.73% in the ibuprofen group, improved by 50.3% in the AAB group, and improved 63.1% in the combination group. C-reactive protein in the ibuprofen group increased by 60.1%, decreased by 47.1% in the AAB group, and decreased by 36% in the combination group. Similar changes were seen in interleukin 6. Arginine, serine, histidine, and tryptophan levels were substantially reduced before treatment in the chronic pain syndrome and increased toward normal during treatment. There was a direct correlation between

  7. Nineteenth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    Ramey, H.J. Jr.; Horne, R.J.; Kruger, P.; Miller, F.G.; Brigham, W.E.; Cook, J.W.

    1994-01-20

    PREFACE The Nineteenth Workshop on Geothermal Reservoir Engineering was held at Stanford University on January 18-20, 1994. This workshop opened on a sad note because of the death of Prof. Henry J. Ramey, Jr. on November 19, 1993. Hank had been fighting leukemia for a long time and finally lost the battle. Many of the workshop participants were present for the celebration of his life on January 21 at Stanford's Memorial Church. Hank was one of the founders of the Stanford Geothermal Program and the Geothermal Reservoir Engineering Workshop. His energy, kindness, quick wit, and knowledge will long be missed at future workshops. Following the Preface we have included a copy of the Memorial Resolution passed by the Stanford University Senate. There were one hundred and four registered participants. Participants were from ten foreign countries: Costa Rica, England, Iceland, Italy, Japan, Kenya, Mexico, New Zealand, Philippines and Turkey. Workshop papers described the performance of fourteen geothermal fields outside the United States. Roland N. Home opened the meeting and welcomed the visitors to the campus. The key note speaker was J.E. ''Ted'' Mock who gave a presentation about the future of geothermal development. The banquet speaker was Jesus Rivera and he spoke about Energy Sources of Central American Countries. Forty two papers were presented at the Workshop. Technical papers were organized in twelve sessions concerning: sciences, injection, production, modeling, and adsorption. Session chairmen are an important part of the workshop and our thanks go to: John Counsil, Mark Walters, Dave Duchane, David Faulder, Gudmundur Bodvarsson, Jim Lovekin, Joel Renner, and Iraj Ershaghi. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank Pat Ota, Ted Sumida, and Terri A. Ramey who also produces the Proceedings Volumes for publication. We owe a great deal of thanks to our students who operate audiovisual

  8. Motor features in posterior cortical atrophy and their imaging correlates.

    PubMed

    Ryan, Natalie S; Shakespeare, Timothy J; Lehmann, Manja; Keihaninejad, Shiva; Nicholas, Jennifer M; Leung, Kelvin K; Fox, Nick C; Crutch, Sebastian J

    2014-12-01

    Posterior cortical atrophy (PCA) is a neurodegenerative syndrome characterized by impaired higher visual processing skills; however, motor features more commonly associated with corticobasal syndrome may also occur. We investigated the frequency and clinical characteristics of motor features in 44 PCA patients and, with 30 controls, conducted voxel-based morphometry, cortical thickness, and subcortical volumetric analyses of their magnetic resonance imaging. Prominent limb rigidity was used to define a PCA-motor subgroup. A total of 30% (13) had PCA-motor; all demonstrating asymmetrical left upper limb rigidity. Limb apraxia was more frequent and asymmetrical in PCA-motor, as was myoclonus. Tremor and alien limb phenomena only occurred in this subgroup. The subgroups did not differ in neuropsychological test performance or apolipoprotein E4 allele frequency. Greater asymmetry of atrophy occurred in PCA-motor, particularly involving right frontoparietal and peri-rolandic cortices, putamen, and thalamus. The 9 patients (including 4 PCA-motor) with pathology or cerebrospinal fluid all showed evidence of Alzheimer's disease. Our data suggest that PCA patients with motor features have greater atrophy of contralateral sensorimotor areas but are still likely to have underlying Alzheimer's disease. PMID:25086839

  9. The Effect of Harmonic Technique vs End Range Loading Exercises on Pain and Disability in Patients With Non-Specific Chronic Low Back Pain: A Preliminary Study

    PubMed Central

    Arab, Amir Massoud; Saadati, Heidar; Sheikhhoseini, Rahman

    2016-01-01

    Objective The purpose of this study was to compare the effects of end range loading (ERL) vs harmonic technique (HT) on patients with chronic low back pain (LBP). Method Fourteen volunteer patients with LBP were randomly assigned to 2 groups based on a blocked randomization method with 7 patients in the HT group and 7 patients in the ERL group. The patients received 10 sessions of treatment for 5 sessions per week. Pain intensity and disability score were recorded using the numeric pain scale and Roland-Morris Disability questionnaire (RMQ), respectively, before and after the treatment period. Results Although pain intensity (P = .02) and the RMQ score (P = .03) decreased in the HT technique group, no statistically significant change was found in the ERL group for the RMQ score (P > .05). The effect size for HT was .6 and .3 for numeric pain scale and RMQ, respectively. Conclusion This preliminary study showed that pain intensity and disability improved in subjects with chronic LBP in the HT group. More investigations with larger sample size are needed to clarify these findings. PMID:27069426

  10. Syndromes with very low risk of acute prolonged seizures.

    PubMed

    Bast, Thomas

    2014-10-01

    The provision of rescue medication is an important component in the treatment of epilepsy. An intervention within five to ten minutes in the case of an acute prolonged seizure may preserve the patient from status epilepticus (SE). However, the risk of convulsive SE (CSE) differs markedly between patients depending on individual factors. This report summarizes the literature on risk factors for CSE in children with epilepsy and adolescents, and discusses the hypothesis that some electroclinical syndromes engender a very low risk of CSE. The most important risk factor for SE is the history of a previous event. The longer a patient lives without SE, the lower the risk will be. CSE occurs significantly less frequently in idiopathic epilepsies compared to epilepsies with symptomatic or unknown aetiology. It is very rarely observed in patients with (non-encephalopathic) idiopathic generalised epilepsies, i.e. childhood absence epilepsy or juvenile myoclonic epilepsy. However, non-compliance or inappropriate treatment may trigger CSE in these syndromes. A very low risk can be assumed for children with Rolandic epilepsy, while CSE occurs in a considerable percentage of patients with Panayiotopoulos syndrome. Although the risk of CSE in otherwise normal children with cryptogenic focal epilepsy is uncertain, it is presumably low under successful continuous medication. In conclusion, the choice for or against the prescription of rescue medication remains an individual decision. Consequently, for several electroclinical syndromes, a per se provision of rescue medication does not appear justified. PMID:25322851

  11. Neurobiological changes of schizotypy: evidence from both volume-based morphometric analysis and resting-state functional connectivity.

    PubMed

    Wang, Yi; Yan, Chao; Yin, Da-zhi; Fan, Ming-xia; Cheung, Eric F C; Pantelis, Christos; Chan, Raymond C K

    2015-03-01

    The current study sought to examine the underlying brain changes in individuals with high schizotypy by integrating networks derived from brain structural and functional imaging. Individuals with high schizotypy (n = 35) and low schizotypy (n = 34) controls were screened using the Schizotypal Personality Questionnaire and underwent brain structural and resting-state functional magnetic resonance imaging on a 3T scanner. Voxel-based morphometric analysis and graph theory-based functional network analysis were conducted. Individuals with high schizotypy showed reduced gray matter (GM) density in the insula and the dorsolateral prefrontal gyrus. The graph theoretical analysis showed that individuals with high schizotypy showed similar global properties in their functional networks as low schizotypy individuals. Several hubs of the functional network were identified in both groups, including the insula, the lingual gyrus, the postcentral gyrus, and the rolandic operculum. More hubs in the frontal lobe and fewer hubs in the occipital lobe were identified in individuals with high schizotypy. By comparing the functional connectivity between clusters with abnormal GM density and the whole brain, individuals with high schizotypy showed weaker functional connectivity between the left insula and the putamen, but stronger connectivity between the cerebellum and the medial frontal gyrus. Taken together, our findings suggest that individuals with high schizotypy present changes in terms of GM and resting-state functional connectivity, especially in the frontal lobe. PMID:25533270

  12. Brain Structural Alterations in Obsessive-Compulsive Disorder Patients with Autogenous and Reactive Obsessions

    PubMed Central

    Subirà, Marta; Alonso, Pino; Segalàs, Cinto; Real, Eva; López-Solà, Clara; Pujol, Jesús; Martínez-Zalacaín, Ignacio; Harrison, Ben J.; Menchón, José M.; Cardoner, Narcís; Soriano-Mas, Carles

    2013-01-01

    Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition. Although structural brain alterations have been consistently reported in OCD, their interaction with particular clinical subtypes deserves further examination. Among other approaches, a two-group classification in patients with autogenous and reactive obsessions has been proposed. The purpose of the present study was to assess, by means of a voxel-based morphometry analysis, the putative brain structural correlates of this classification scheme in OCD patients. Ninety-five OCD patients and 95 healthy controls were recruited. Patients were divided into autogenous (n = 30) and reactive (n = 65) sub-groups. A structural magnetic resonance image was acquired for each participant and pre-processed with SPM8 software to obtain a volume-modulated gray matter map. Whole-brain and voxel-wise comparisons between the study groups were then performed. In comparison to the autogenous group, reactive patients showed larger gray matter volumes in the right Rolandic operculum. When compared to healthy controls, reactive patients showed larger volumes in the putamen (bilaterally), while autogenous patients showed a smaller left anterior temporal lobe. Also in comparison to healthy controls, the right middle temporal gyrus was smaller in both patient subgroups. Our results suggest that autogenous and reactive obsessions depend on partially dissimilar neural substrates. Our findings provide some neurobiological support for this classification scheme and contribute to unraveling the neurobiological basis of clinical heterogeneity in OCD. PMID:24098688

  13. The Neural Basis of Vocal Pitch Imitation in Humans.

    PubMed

    Belyk, Michel; Pfordresher, Peter Q; Liotti, Mario; Brown, Steven

    2016-04-01

    Vocal imitation is a phenotype that is unique to humans among all primate species, and so an understanding of its neural basis is critical in explaining the emergence of both speech and song in human evolution. Two principal neural models of vocal imitation have emerged from a consideration of nonhuman animals. One hypothesis suggests that putative mirror neurons in the inferior frontal gyrus pars opercularis of Broca's area may be important for imitation. An alternative hypothesis derived from the study of songbirds suggests that the corticostriate motor pathway performs sensorimotor processes that are specific to vocal imitation. Using fMRI with a sparse event-related sampling design, we investigated the neural basis of vocal imitation in humans by comparing imitative vocal production of pitch sequences with both nonimitative vocal production and pitch discrimination. The strongest difference between these tasks was found in the putamen bilaterally, providing a striking parallel to the role of the analogous region in songbirds. Other areas preferentially activated during imitation included the orofacial motor cortex, Rolandic operculum, and SMA, which together outline the corticostriate motor loop. No differences were seen in the inferior frontal gyrus. The corticostriate system thus appears to be the central pathway for vocal imitation in humans, as predicted from an analogy with songbirds. PMID:26696298

  14. Quark Matter 2011 (QM11) Quark Matter 2011 (QM11)

    NASA Astrophysics Data System (ADS)

    2011-12-01

    International Advisory Committee Antinori, FedericoPaic, Guy Braun-Munzinger, PeterPajares, Carlos Cifarelli, LuisaPeitzmann, Thomas Erazmus, BarbaraRedlich, Krzysztof Eskola, KariRiccati, Lodovico Gaardhøje, Jens JørgenRoland, Gunther Gale, CharlesRoy, Christelle Gelis, FrancoisSchukraft, Jürgen Giubellino, PaoloSinha, Bikash Greiner, CarstenSrivastava, Dinesh Gyulassy, MiklosStachel, Johanna Harris, JohnSteinberg, Peter Hatsuda, TetsuoStroth, Joachim Heinz, UlrichSugitate, Toru Jacak, BarbaraTserruya, Itzhak Karsch, FrithjofVelkovska, Julia Kharzeev, DimaWang, Enke Kodama, TakeshiWang, Xin, Nian Lévai, PéterWessels, Johannes Manko, VladislavXu, Nu Müller, BerndtZajc, William Ollitrault, Jean-Yves Organizing Committee Arleo, FrancoisDupieux, Pascal Bastid, NicoleFurget, Christophe Bourgeois, Marie-LaureGranier de Cassagnac, Raphael Bregant, MarcoGuernane, Rachid Carminati, FedericoHervet, Carnita Castillo, JavierKuhn, Christian Cheynis, BrigitteOlivier, Nathalie Conesa, DelValle, Zaida Connor, MichelleRenshall, Lucy Crochet, PhilippeSuire, Christophe Delagrange, HuguesTihinen, Ulla Program Committee Schutz, Yves (Chair)Baldisseri, Alberto Wiedemann, Urs (co-Chair)Safarik, Karel Aurenche, Patrick

  15. Electrocorticographic amplitude predicts finger positions during slow grasping motions of the hand

    NASA Astrophysics Data System (ADS)

    Acharya, Soumyadipta; Fifer, Matthew S.; Benz, Heather L.; Crone, Nathan E.; Thakor, Nitish V.

    2010-08-01

    Four human subjects undergoing subdural electrocorticography for epilepsy surgery engaged in a range of finger and hand movements. We observed that the amplitudes of the low-pass filtered electrocorticogram (ECoG), also known as the local motor potential (LMP), over specific peri-Rolandic electrodes were correlated (p < 0.001) with the position of individual fingers as the subjects engaged in slow and deliberate grasping motions. A generalized linear model (GLM) of the LMP amplitudes from those electrodes yielded predictions for positions of the fingers that had a strong congruence with the actual finger positions (correlation coefficient, r; median = 0.51, maximum = 0.91), during displacements of up to 10 cm at the fingertips. For all the subjects, decoding filters trained on data from any given session were remarkably robust in their prediction performance across multiple sessions and days, and were invariant with respect to changes in wrist angle, elbow flexion and hand placement across these sessions (median r = 0.52, maximum r = 0.86). Furthermore, a reasonable prediction accuracy for grasp aperture was achievable with as few as three electrodes in all subjects (median r = 0.49; maximum r = 0.90). These results provide further evidence for the feasibility of robust and practical ECoG-based control of finger movements in upper extremity prosthetics.

  16. The phi complex as a neuromarker of human social coordination

    PubMed Central

    Tognoli, Emmanuelle; Lagarde, Julien; DeGuzman, Gonzalo C.; Kelso, J. A. Scott

    2007-01-01

    Many social interactions rely upon mutual information exchange: one member of a pair changes in response to the other while at the same time producing actions that alter the behavior of the other. However, little is known about how such social processes are integrated in the brain. Here, we used a specially designed dual-electroencephalogram system and the conceptual framework of coordination dynamics to identify neural signatures of effective, real-time coordination between people and its breakdown or absence. High-resolution spectral analysis of electrical brain activity before and during visually mediated social coordination revealed a marked depression in occipital alpha and rolandic mu rhythms during social interaction that was independent of whether behavior was coordinated or not. In contrast, a pair of oscillatory components (phi1 and phi2) located above right centro-parietal cortex distinguished effective from ineffective coordination: increase of phi1 favored independent behavior and increase of phi2 favored coordinated behavior. The topography of the phi complex is consistent with neuroanatomical sources within the human mirror neuron system. A plausible mechanism is that the phi complex reflects the influence of the other on a person's ongoing behavior, with phi1 expressing the inhibition of the human mirror neuron system and phi2 its enhancement. PMID:17470821

  17. Learning piano melodies in visuo-motor or audio-motor training conditions and the neural correlates of their cross-modal transfer.

    PubMed

    Engel, Annerose; Bangert, Marc; Horbank, David; Hijmans, Brenda S; Wilkens, Katharina; Keller, Peter E; Keysers, Christian

    2012-11-01

    To investigate the cross-modal transfer of movement patterns necessary to perform melodies on the piano, 22 non-musicians learned to play short sequences on a piano keyboard by (1) merely listening and replaying (vision of own fingers occluded) or (2) merely observing silent finger movements and replaying (on a silent keyboard). After training, participants recognized with above chance accuracy (1) audio-motor learned sequences upon visual presentation (89±17%), and (2) visuo-motor learned sequences upon auditory presentation (77±22%). The recognition rates for visual presentation significantly exceeded those for auditory presentation (p<.05). fMRI revealed that observing finger movements corresponding to audio-motor trained melodies is associated with stronger activation in the left rolandic operculum than observing untrained sequences. This region was also involved in silent execution of sequences, suggesting that a link to motor representations may play a role in cross-modal transfer from audio-motor training condition to visual recognition. No significant differences in brain activity were found during listening to visuo-motor trained compared to untrained melodies. Cross-modal transfer was stronger from the audio-motor training condition to visual recognition and this is discussed in relation to the fact that non-musicians are familiar with how their finger movements look (motor-to-vision transformation), but not with how they sound on a piano (motor-to-sound transformation). PMID:22484310

  18. Sleep and Epilepsy: Strange Bedfellows No More

    PubMed Central

    St. Louis, Erik K.

    2012-01-01

    Ancient philosophers and theologians believed that altered consciousness freed the mind to prophesy the future, equating sleep with seizures. Only recently has the bidirectional influences of epilepsy and sleep upon one another received more substantive analysis. This article reviews the complex and increasingly recognized interrelationships between sleep and epilepsy. NREM sleep differentially activates interictal epileptiform discharges during slow wave (N3) sleep, while ictal seizure events occur more frequently during light NREM stages N1 and N2. The most commonly encountered types of sleep-related epilepsies (those with preferential occurrence during sleep or following arousal) include frontal and temporal lobe partial epilepsies in adults, and benign epilepsy of childhood with centrotemporal spikes (benign rolandic epilepsy) and juvenile myoclonic epilepsy in children and adolescents. Comorbid sleep disorders are frequent in patients with epilepsy, particularly obstructive sleep apnea in refractory epilepsy patients which may aggravate seizure burden, while treatment with nasal continuous positive airway pressure often improves seizure frequency. Distinguishing nocturnal events such as NREM parasomnias (confusional arousals, sleep walking, and night terrors), REM parasomnias including REM sleep behavior disorder, and nocturnal seizures if frequently difficult and benefits from careful history taking and video-EEG-polysomnography in selected cases. Differentiating nocturnal seizures from primary sleep disorders is essential for determining appropriate therapy, and recognizing co-existent sleep disorders in patients with epilepsy may improve their seizure burden and quality of life. PMID:23539488

  19. Early deficits in cortical control of swallowing in Alzheimer’s disease

    PubMed Central

    Humbert, Ianessa A.; McLaren, Donald G.; Kosmatka, Kris; Fitzgerald, Michelle; Johnson, Sterling; Porcaro, Eva; Kays, Stephanie; Umoh, Eno-Obong; Robbins, JoAnne

    2010-01-01

    The goal of this study was to determine whether functional changes in cortical control of swallowing are evident in early Alzheimer’s disease (AD), before dysphagia (swallowing impairment) is evident. Cortical function was compared between an early AD group and a group of age-matched controls during swallowing. Swallowing oropharyngeal biomechanics examined from videofluoroscopic recordings were also obtained to more comprehensively characterize changes in swallowing associated with early AD. Our neuroimaging results show that the AD group had significantly lower BOLD response in many cortical areas that are traditionally involved in normal swallowing (i.e. pre and postcentral gyri, Rolandic and frontal opercula). There were no regions where the AD group recruited more brain activity than the healthy controls during swallowing and only 13% of all active voxels were unique to the AD group, even at this early stage. This suggests that the AD group is not recruiting new regions, nor are they compensating within regions that are active during swallowing. In videofluoroscopic measures, the AD group had significantly reduced hyo-laryngeal elevation than the controls. Although, swallowing impairment is usually noted in the late stages of AD, changes in cortical control of swallowing may begin long before dysphagia becomes apparent. PMID:20308785

  20. Twentieth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    1995-01-26

    PREFACE The Twentieth Workshop on Geothermal Reservoir Engineering, dedicated to the memory of Professor Hank Ramey, was held at Stanford University on January 24-26, 1995. There were ninety-five registered participants. Participants came from six foreign countries: Japan, Mexico, England, Italy, New Zealand and Iceland. The performance of many geothermal reservoirs outside the United States was described in several of the papers. Professor Roland N. Horne opened the meeting and welcomed visitors to the campus. The key note speaker was Marshall Reed, who gave a brief overview of the Department of Energy's current plan. Thirty-two papers were presented in the technical sessions of the workshop. Technical papers were organized into eleven sessions concerning: field development, modeling, well tesubore, injection, geoscience, geochemistry and field operations. Session chairmen were major contributors to the workshop, and we thank: Ben Barker, Bob Fournier, Mark Walters, John Counsil, Marcelo Lippmann, Keshav Goyal, Joel Renner and Mike Shook. In addition to the technical sessions, a panel discussion was held on ''What have we learned in 20 years?'' Panel speakers included Patrick Muffler, George Frye, Alfred Truesdell and John Pritchett. The subject was further discussed by Subir Sanyal, who gave the post-dinner speech at the banquet. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank our students who operated the audiovisual equipment. Shaun D. Fitzgerald Program Manager

  1. Aberrant functional brain connectome in people with antisocial personality disorder

    PubMed Central

    Tang, Yan; Long, Jun; Wang, Wei; Liao, Jian; Xie, Hua; Zhao, Guihu; Zhang, Hao

    2016-01-01

    Antisocial personality disorder (ASPD) is characterised by a disregard for social obligations and callous unconcern for the feelings of others. Studies have demonstrated that ASPD is associated with abnormalities in brain regions and aberrant functional connectivity. In this paper, topological organisation was examined in resting-state fMRI data obtained from 32 ASPD patients and 32 non-ASPD controls. The frequency-dependent functional networks were constructed using wavelet-based correlations over 90 brain regions. The topology of the functional networks of ASPD subjects was analysed via graph theoretical analysis. Furthermore, the abnormal functional connectivity was determined with a network-based statistic (NBS) approach. Our results revealed that, compared with the controls, the ASPD patients exhibited altered topological configuration of the functional connectome in the frequency interval of 0.016–0.031 Hz, as indicated by the increased clustering coefficient and decreased betweenness centrality in the medial superior frontal gyrus, precentral gyrus, Rolandic operculum, superior parietal gyrus, angular gyrus, and middle temporal pole. In addition, the ASPD patients showed increased functional connectivity mainly located in the default-mode network. The present study reveals an aberrant topological organisation of the functional brain network in individuals with ASPD. Our findings provide novel insight into the neuropathological mechanisms of ASPD. PMID:27257047

  2. Map Showing Principal Coal Beds and Bedrock Geology of the Ucross-Arvada Area, Central Powder River Basin, Wyoming

    USGS Publications Warehouse

    Molnia, Carol L.

    2013-01-01

    The Ucross-Arvada area is part of the Powder River Basin, a large, north-trending structural depression between the Black Hills on the east and the Bighorn Mountains on the west. Almost all of the study area is within Sheridan and Johnson Counties, Wyoming. Most of the Ucross-Arvada area lies within the outcrop of the Wasatch Formation of Eocene age; the extreme northeast corner falls within the outcrop of the Tongue River Member of the Fort Union Formation of Paleocene age. Within the Powder River Basin, both the Wasatch Formation and the Tongue River Member of the Fort Union Formation contain significant coal resources. The map includes locations and elevations of coal beds at 1:50,000 scale for an area that includes ten 7½-minute quadrangles covering some 500 square miles. The Wasatch Formation coal beds shown (in descending order) are Monument Peak, Walters (also called Ulm 1), Healy (also called Ulm 2), Truman, Felix, and Arvada. The Fort Union Formation coal beds shown (in descending order) are Roland (of Baker, 1929) and Smith.

  3. Comparison between Kinesio Taping and a Traditional Physical Therapy Program in Treatment of Nonspecific Low Back Pain

    PubMed Central

    Kachanathu, Shaji John; Alenazi, Aqeel M.; Seif, Hamada Eid; Hafez, Ashraf Ramadan; Alroumim, Meshari Abdulmohsen

    2014-01-01

    [Purpose] Nonspecific low back pain (NSLBP) is a very common but largely self-limiting condition. Several types of tape and their associated application methods are available for different conditions. The aim of the present study was to observe the effect of Kinesio taping (KT) compared with traditional management of NSLBP. [Subjects and Methods] Forty male and female patients with a mean age of 34.8±7.54 years were randomly divided into two groups; group 1 (n=20) which underwent conventional physical therapy with KT, and group 2 (n=20), which underwent only conventional physical therapy. The intervention sessions for both groups were three times per week for four weeks. Outcomes were assessed for activities of daily living (ADL) using the Roland-Morris Disability Questionnaire, pain severity using a visual analogue scale, and ranges of motion (ROMs) of trunk flexion and extension using the modified Schober’s test. [Results] Significant differences in measures of pain, ADL, and trunk flexion and extension ROMs were observed post intervention within each group. In comparison, there were no significant differences in measures of pain, ADL, and trunk flexion and extension ROMs post intervention between groups. [Conclusion] A physical therapy program involving strengthening exercises for abdominal muscles and stretching exercises for back, hamstring, and iliopsoas muscles with or without Kinesio taping was beneficial in the treatment of chronic low back pain. PMID:25202177

  4. Statistical design of a uranium corrosion experiment

    SciTech Connect

    Wendelberger, Joanne R; Moore, Leslie M

    2009-01-01

    This work supports an experiment being conducted by Roland Schulze and Mary Ann Hill to study hydride formation, one of the most important forms of corrosion observed in uranium and uranium alloys. The study goals and objectives are described in Schulze and Hill (2008), and the work described here focuses on development of a statistical experiment plan being used for the study. The results of this study will contribute to the development of a uranium hydriding model for use in lifetime prediction models. A parametric study of the effect of hydrogen pressure, gap size and abrasion on hydride initiation and growth is being planned where results can be analyzed statistically to determine individual effects as well as multi-variable interactions. Input to ESC from this experiment will include expected hydride nucleation, size, distribution, and volume on various uranium surface situations (geometry) as a function of age. This study will also address the effect of hydrogen threshold pressure on corrosion nucleation and the effect of oxide abrasion/breach on hydriding processes. Statistical experiment plans provide for efficient collection of data that aids in understanding the impact of specific experiment factors on initiation and growth of corrosion. The experiment planning methods used here also allow for robust data collection accommodating other sources of variation such as the density of inclusions, assumed to vary linearly along the cast rods from which samples are obtained.

  5. Density scaling of the transport properties of molecular and ionic liquids.

    PubMed

    López, Enriqueta R; Pensado, Alfonso S; Comuñas, María J P; Pádua, Agílio A H; Fernández, Josefa; Harris, Kenneth R

    2011-04-14

    Casalini and Roland [Phys. Rev. E 69, 062501 (2004); J. Non-Cryst. Solids 353, 3936 (2007)] and other authors have found that both the dielectric relaxation times and the viscosity, η, of liquids can be expressed solely as functions of the group (TV (γ)), where T is the temperature, V is the molar volume, and γ a state-independent scaling exponent. Here we report scaling exponents γ, for the viscosities of 46 compounds, including 11 ionic liquids. A generalization of this thermodynamic scaling to other transport properties, namely, the self-diffusion coefficients for ionic and molecular liquids and the electrical conductivity for ionic liquids is examined. Scaling exponents, γ, for the electrical conductivities of six ionic liquids for which viscosity data are available, are found to be quite close to those obtained from viscosities. Using the scaling exponents obtained from viscosities it was possible to correlate molar conductivity over broad ranges of temperature and pressure. However, application of the same procedures to the self-diffusion coefficients, D, of six ionic and 13 molecular liquids leads to superpositioning of poorer quality, as the scaling yields different exponents from those obtained with viscosities and, in the case of the ionic liquids, slightly different values for the anion and the cation. This situation can be improved by using the ratio (D∕T), consistent with the Stokes-Einstein relation, yielding γ values closer to those of viscosity. PMID:21495764

  6. Neural correlates of taste perception in congenital blindness.

    PubMed

    Gagnon, L; Kupers, R; Ptito, M

    2015-04-01

    Sight is undoubtedly important for the perception and the assessment of the palatability of tastants. Although many studies have addressed the consequences of visual impairment on food selection, feeding behavior, eating habits and taste perception, nothing is known about the neural correlates of gustation in blindness. In the current study we examined brain responses during gustation using functional magnetic resonance imaging (fMRI). We scanned nine congenitally blind and 14 age- and sex-matched blindfolded sighted control subjects, matched in age, gender and body mass index (BMI), while they made judgments of either the intensity or the (un)pleasantness of different tastes (sweet, bitter) or artificial saliva that were delivered intra-orally. The fMRI data indicated that during gustation, congenitally blind individuals activate less strongly the primary taste cortex (right posterior insula and overlying Rolandic operculum) and the hypothalamus. In sharp contrast with results of multiple other sensory processing studies in congenitally blind subjects, including touch, audition and smell, the occipital cortex was not recruited during taste processing, suggesting the absence of taste-related compensatory crossmodal responses in the occipital cortex. These results underscore our earlier behavioral demonstration that congenitally blind subjects have a lower gustatory sensitivity compared to normal sighted individuals. We hypothesize that due to an underexposure to a variety of tastants, training-induced crossmodal sensory plasticity to gustatory stimulation does not occur in blind subjects. PMID:25708174

  7. INDIAN CASTE SYSTEM: HISTORICAL AND PSYCHOANALYTIC VIEWS.

    PubMed

    Vallabhaneni, Madhusudana Rao

    2015-12-01

    This paper elucidates the historical origins and transformations of India's caste system. Surveying the complex developments over many centuries, it points out that three positions have been taken in this regard. One suggests that the caste one is born into can be transcended within one's lifetime by performing good deeds. The other declares caste to be immutable forever. And, the third says that one can be reborn into a higher caste if one lives a virtuous life. Moving on to the sociopolitical realm, the paper notes how these positions have been used and exploited. The paper then attempts to anchor the existence and purpose of the Hindu caste system in Freud's ideas about group psychology and Klein's proposals of splitting and projective identification. The paper also deploys the large group psychology concepts of Volkan and the culturally nuanced psychoanalytic anthropology of Roland and Kakar. It concludes with delineating some ameliorative strategies for this tragic problem in the otherwise robust democratic society of India. PMID:26611129

  8. Framing the ultimatum game: the contribution of simulation.

    PubMed

    Tomasino, Barbara; Lotto, Lorella; Sarlo, Michela; Civai, Claudia; Rumiati, Rino; Rumiati, Raffaella I

    2013-01-01

    It has now become widely accepted that economic decisions are influenced by cognitive and emotional processes. In the present study, we aimed at disentangling the neural mechanisms associated with the way in which the information is formulated, i.e., framing effect, in terms of gain or loss, which influences people's decisions. Participants played a fMRI version of the Ultimatum Game (UG) where we manipulated bids through two different frames: the expression "I give you" (gain) focusing on money the respondent would receive if she/he agreed with the proponent, and the expression "I take" (loss) focusing on the money that would be removed from the respondent in the event that she/he accepted the offer. Neuroimaging data revealed a frame by response interaction, showing an increase of neural activity in the right rolandic operculum/insular cortex, the anterior cingulate, among other regions, for accepting the frame "I take" vs. rejecting, as compared to accepting the frame "I give you" vs. rejecting. In addition, the left occipito-temporal junction was activated for "I take" vs. "I give you" for offer 5, corresponding to the equal offer made unpleasant by the presence of the frame "I take," where is the proposer that takes the money. Our data extend the current understanding of the neural substrates of social decision making, by disentangling the structures sensitive to the way in which the information is formulated (i.e., framing effect), in terms of gain or loss. PMID:23847507

  9. Intelligence-related differences in the asymmetry of spontaneous cerebral activity.

    PubMed

    Santarnecchi, Emiliano; Tatti, Elisa; Rossi, Simone; Serino, Vinicio; Rossi, Alessandro

    2015-09-01

    Recent evidence suggests the spontaneous BOLD signal synchronization of corresponding interhemispheric, homotopic regions as a stable trait of human brain physiology, with emerging differences in such organization being also related to some pathological conditions. To understand whether such brain functional symmetries play a role into higher-order cognitive functioning, here we correlated the functional homotopy profiles of 119 healthy subjects with their intelligence level. Counterintuitively, reduced homotopic connectivity in above average-IQ versus average-IQ subjects was observed, with significant reductions in visual and somatosensory cortices, supplementary motor area, rolandic operculum, and middle temporal gyrus, possibly suggesting that a downgrading of interhemispheric talk at rest could be associated with higher cognitive functioning. These regions also showed an increased spontaneous synchrony with medial structures located in ipsi- and contralateral hemispheres, with such pattern being mostly detectable for regions placed in the left hemisphere. The interactions with age and gender have been also tested, with different patterns for subjects above and below 25 years old and less homotopic connectivity in the prefrontal cortex and posterior midline regions in female participants with higher IQ scores. These findings support prior evidence suggesting a functional role for homotopic connectivity in human cognitive expression, promoting the reduction of synchrony between primary sensory regions as a predictor of higher intelligence levels. PMID:26059228

  10. A voxel-based morphometry (VBM) analysis of regional grey and white matter volume abnormalities within the speech production network of children who stutter

    PubMed Central

    Beal, Deryk S.; Gracco, Vincent L.; Brettschneider, Jane; Kroll, Robert M.; De Nil, Luc F.

    2012-01-01

    It is well documented that neuroanatomical differences exist between adults who stutter and their fluently speaking peers. Specifically, adults who stutter have been found to have more grey matter volume (GMV) in speech relevant regions including inferior frontal gyrus, insula and superior temporal gyrus (Beal et al., 2007; Song et al., 2007). Despite stuttering having its onset in childhood only one study has investigated the neuroanatomical differences between children who do and do not stutter. Chang et al. (2008) reported children who stutter had less GMV in the bilateral inferior frontal gyri and middle temporal gyrus relative to fluently speaking children. Thus it appears that children who stutter present with unique neuroanatomical abnormalities as compared to those of adults who stutter. In order to better understand the neuroanatomical correlates of stuttering earlier in its development, near the time of onset, we used voxel-based morphometry to examine volumetric differences between 11 children who stutter and 11 fluent children. Children who stutter had less GMV in the bilateral inferior frontal gyri and left putamen but more GMV in right Rolandic operculum and superior temporal gyrus relative to fluent children. Children who stutter also had less white matter volume bilaterally in the forceps minor of the corpus callosum. We discuss our findings of widespread anatomic abnormalities throughout the cortical network for speech motor control within the context of the speech motor skill limitations identified in people who stutter (Namasivayam and van Lieshout, 2008; Smits-Bandstra et al., 2006). PMID:23140891

  11. Is v3 necessary or even informative in describing angular correlation data from RHIC and the LHC?

    NASA Astrophysics Data System (ADS)

    Ray, Lanny; Trainor, Thomas; Prindle, Duncan

    2013-10-01

    One of the more interesting observations from the heavy-ion program at RHIC and now at the LHC are long-range correlations on relative pseudorapidity at small azimuth opening angles. In 2010 Alver and Roland suggested that this so-called same-side ridge could be explained in terms of higher-order, azimuth cosine distributions generated by event-wise energy density fluctuations in the initial-state plus hydrodynamic flow. Applications of third- and higher-order harmonics in analysis of angular correlations from heavy-ion collisions have become ubiquitous in the literature. However, we question the introduction of ``higher harmonics'' to the 2D data description. Extending previous work we examine the necessity and utility of v3. We find that the net effect of v3 is to accommodate minor non-Gaussian structure in the same-side 2D peak for pt-integral correlations from RHIC. A single Gaussian hypothesis for those data is not falsified within statistics. Model ambiguities and instabilities resulting from v3 are discussed and resolved. Lastly, we demonstrate that the 0-1% angular correlation data for 2.76 TeV Pb-Pb collisions from ATLAS do not require a v3 component. Supported in part by the U.S. Dept. of Energy.

  12. Auricular Point Acupressure to Manage Chronic Low Back Pain in Older Adults: A Randomized Controlled Pilot Study

    PubMed Central

    Morone, Natalia E.; Cao, Yuling; Shen, Juan; Bhatnagar, Shreya; Liang, Zhan; Glick, Ronald M.; Suen, Lorna Kwai-Ping

    2014-01-01

    This prospective, randomized clinical trial (RCT) pilot study was designed to (1) assess the feasibility and tolerability of an easily administered, auricular point acupressure (APA) intervention and (2) provide an initial assessment of effect size as compared to a sham treatment. Thirty-seven subjects were randomized to receive either the real or sham APA treatment. All participants were treated once a week for 4 weeks. Self-report measures were obtained at baseline, weekly during treatment, at end-of-intervention (EOI), and at a 1-month follow-up. A dropout rate of 26% in the real APA group and 50% in the sham group was observed. The reduction in worst pain from baseline to EOI was 41% for the real and 5% for the sham group with a Cohen's effect size of 1.22 (P < 0.00). Disability scores on the Roland Morris Disability Questionnaire (RMDQ) decreased in the real group by 29% and were unchanged in the sham group (+3%) (P < 0.00). Given the high dropout rate, results must be interpreted with caution; nevertheless, our results suggest that APA may provide an inexpensive and effective complementary approach for the management of back pain in older adults, and further study is warranted. PMID:25147574

  13. Work-Related Low Back Pain Treatment: A Randomized Controlled Trial from Tehran, Iran, Comparing Multidisciplinary Educational Program versus Physiotherapy Education

    PubMed Central

    Ghadyani, Leila; Kazemnejad, Anoshirvan; Wagner, Joan

    2016-01-01

    Study Design Clinical trial. Purpose To compare the multidisciplinary educational program versus physiotherapy education among Iranian nurses. Overview of Literature Low back pain (LBP) can accompany significant occupational injuries in the nursing profession. There is no agreement on the most effective educational practice. Methods This study was conducted from August 17, 2014 to September 22, 2014 in Tehran, Iran. Eligible nurses with chronic mechanical LBP (n=136) were classified into an intervention group (n=66) or the control group (n=70). The intervention group received physiotherapy education for 120-minutes followed by a 120-minute health education session based on predictive constructs of social cognitive theory (SCT). The control group received the 120-minute physiotherapy education. Disability rate, pain severity and back pain prevention behavior were measured at initially and 3 months after intervention using visual analogue scale, Roland-Morris disability questionnaire and nursing low back pain preventive behaviors questionnaire. Results The two groups were the same in terms of all studied variables at the initiation of the study. At the 3-month follow up, predictive constructs of LBP preventive behaviors of participants in the intervention were improved (p<0.001). Significant decreases were evident at 3 months in pain severity (p=0.03) and disability (p=0.003). Conclusions The designed multidisciplinary educational intervention could decrease chronic mechanical LBP in nurses. PMID:27559449

  14. Coping with sickle cell disease: a profile and perspective of a pioneer self-help group.

    PubMed

    Duncan, D E; Scott, R B

    1988-02-01

    Sickle cell anemia is a chronic, debilitating disease that is passed genetically from generation to generation. It is a disease marked by periods of well-being and crisis, and it has a profound effect on all bodily organs, shortening the lifespan of its victims. The disease also has far-reaching effects on family functioning and relationships. Support for affected families and individuals is therefore a vital component of any management regimen.In the 1960s, the idea for the Association for Sickle Cell Anemia Research (ASCAR) was implemented. The group was spearheaded by Dr. Roland B. Scott and Dr. Angella Ferguson, both of whom were members of the Department of Pediatrics at Freedmen's Hospital (now Howard University Hospital).This group was perhaps the first of its kind, and adopted as its goals education and family support as well as fund-raising to aid in the support of research. This article provides an overview of the development of this group, its organization and activities, as well as an appraisal of its accomplishments. It also offers specific suggestions for formulating similar groups. PMID:3241309

  15. Functional capacity and its associated factors in the elderly with low back pain

    PubMed Central

    Palma, Roger; de Conti, Marta Helena Souza; Quintino, Natasha Mendonça; Gatti, Marcia Aparecida Nuevo; Simeão, Sandra Fiorelli Almeida Penteado; de Vitta, Alberto

    2014-01-01

    OBJECTIVE: To assess the level of functional capacity in subjects aged 60 years and older, who have lower back pain, and its association with demographic, socioeconomic, work-related, lifestyle-related and disease mentioned variables. METHODS: A cross-sectional study was conducted with 246 elderly registered at the Family Health Strategy of Vila São Paulo, Bauru,SP, Brazil, who reported lower back pain and were sampled by a two-stage cluster technique. The subjects were interviewed at home by using a multidimensional instrument (demographic; socioeconomic aspects; life style; work characterization; disease mentioned), and also the IPAQ, the Nordic and the Roland Morris questionnaires. A bivariate and multivariate descriptive logistic regression analysis was carried out. RESULTS: The prevalence of lower back pain in men was of 25.1% and in women it was of 35.1%. The mean score in the functional capacity assessment was 10.46 ± 5.62. A fraction of 67.5% of the elderly demonstrated an inappropriate functional capacity. The age group from 70 to 80 years old, the subjects reporting three or more diseases and the sedentary group presented an independent association with inappropriate functional capacity. CONCLUSION: The older, sedentary subjects and who reported more than three diseases presented low functional capacity. Level of Evidence III, Cross Sectioning. PMID:25538473

  16. Pain intensity, disability and depression in individuals with chronic back pain1

    PubMed Central

    Garbi, Márcia de Oliveira Sakamoto Silva; Hortense, Priscilla; Gomez, Rodrigo Ramon Falconi; da Silva, Talita de Cássia Raminelli; Castanho, Ana Carolina Ferreira; Sousa, Fátima Aparecida Emm Faleiros

    2014-01-01

    OBJECTIVES: to measure the pain intensity, identify the disability and depression levels in people with chronic back pain and to correlate these variables. A cross-sectional, descriptive and exploratory study was undertaken at the Pain Treatment Clinic of the University of São Paulo at Ribeirão Preto Hospital das Clínicas, between February and June 2012, after receiving approval from the Ethics Committee at the University of São Paulo at Ribeirão Preto College of Nursing. METHOD: sixty subjects with chronic back pain participated. The instruments used were: the 11-point Numerical Category Scale, the Roland-Morris Disability Questionnaire and the Beck Depression Inventory. To analyze the data, the arithmetic means, standard deviations and Spearman's correlation coefficient were calculated. RESULTS: the findings show that the participants presented high pain, disability and depression levels. The correlation between pain intensity and disability and between pain intensity and depression was positive and weak and, between disability and depression, positive and moderate. CONCLUSION: the study variables showed moderate and weak indices and the mutual correlations were positive. PMID:25296139

  17. Aberrant functional brain connectome in people with antisocial personality disorder.

    PubMed

    Tang, Yan; Long, Jun; Wang, Wei; Liao, Jian; Xie, Hua; Zhao, Guihu; Zhang, Hao

    2016-01-01

    Antisocial personality disorder (ASPD) is characterised by a disregard for social obligations and callous unconcern for the feelings of others. Studies have demonstrated that ASPD is associated with abnormalities in brain regions and aberrant functional connectivity. In this paper, topological organisation was examined in resting-state fMRI data obtained from 32 ASPD patients and 32 non-ASPD controls. The frequency-dependent functional networks were constructed using wavelet-based correlations over 90 brain regions. The topology of the functional networks of ASPD subjects was analysed via graph theoretical analysis. Furthermore, the abnormal functional connectivity was determined with a network-based statistic (NBS) approach. Our results revealed that, compared with the controls, the ASPD patients exhibited altered topological configuration of the functional connectome in the frequency interval of 0.016-0.031 Hz, as indicated by the increased clustering coefficient and decreased betweenness centrality in the medial superior frontal gyrus, precentral gyrus, Rolandic operculum, superior parietal gyrus, angular gyrus, and middle temporal pole. In addition, the ASPD patients showed increased functional connectivity mainly located in the default-mode network. The present study reveals an aberrant topological organisation of the functional brain network in individuals with ASPD. Our findings provide novel insight into the neuropathological mechanisms of ASPD. PMID:27257047

  18. Plasma-photocatalysis combination for air pollutant removal: identification of the synergy mechanisms

    NASA Astrophysics Data System (ADS)

    Guaitella, O.; Thevenet, F.; Rousseau, A.; Guillard, C.; Stancu, G.; Roepcke, J.

    2006-10-01

    The coupling of a photocatalyst with a non thermal plasma (DBD) is studied; based on experimental results we discuss separately the contributions of (i) the chemistry involved as a function of the porosity of the material, and (ii) the influence of the photocatalytic activity on the chemistry of C2H2 oxidation. C2H2 removal is strongly increased by the presence of a porous material (SiO2 or TiO2): the destruction of C2H2 is driven by species created by the plasma and concentrated by a porous [1]. Our experiments confirm that C2H2 removal rate increases with the porosity of the material, whereas the selectivity also depends on the chemical composition of the surface. In parallel, the temporal evolution of C2H2 concentration was measured by Tuneable Diode Laser Absorption Spectroscopy (TDLAS) in the mid infrared region in a low pressure discharge during a single plasma pulse (one shot). The contribution of external ultraviolet radiation and plasma exposure were quantified, both with and without photocatalyst. The synergetic effect was clearly demonstrated [2]. [1] U. Roland, F. Holzer, F.-D. Kopinke 2002 Catalysis Today 73 315--323 [2] A. Rousseau, O. Guaitella, L.V. Gatilova, F. Thevenet, C. Guillard, J. Roepcke, G. D. Stancu , Appl. Phys. Let. 87, 221501 (2005).

  19. Highlights from SelectBio 2015: Academic Drug Discovery Conference, Cambridge, UK, 19-20 May 2015.

    PubMed

    Spencer, John; Coaker, Hannah

    2015-01-01

    The SelectBio 2015: Academic Drug Discovery Conference was held in Cambridge, UK, on 19-20 May 2015. Building on the success of academic drug discovery events in the USA, this conference aimed to showcase the exciting new research emerging from academic drug discovery and to help bridge the gap between basic research and commercial application. At the event the authors heard from a number of speakers on a broad array of topics, from partnering models for academia and industry to novel drug discovery approaches across various therapeutic areas, with a few talks, such as those by Susanne Muller-Knapp (Structure Genomics Consortium, Oxford University, Oxford, UK) and Julian Blagg (Institute of Cancer Research, UK), covering both remits, by highlighting a number of such partnerships and then delving into some case studies. The conference concluded with a heated debate on whether phenotypic discovery should be favored over targeted discovery in academia and pharma, in a panel discussion chaired by Roland Wolkowicz (San Diego State University, USA). PMID:26420379

  20. Can a self-administered questionnaire identify workers with chronic or recurring low back pain?

    PubMed Central

    TAKEKAWA, Karina Satiko; GONÇALVES, Josiane Sotrate; MORIGUCHI, Cristiane Shinohara; COURY, Helenice Jane Cote Gil; SATO, Tatiana de Oliveira

    2015-01-01

    To verify if the Nordic Musculoskeletal Questionnaire (NMQ), Visual Analogue Scale (VAS), Roland-Morris Disability Questionnaire (RDQ) and physical examination of the lumbar spine can identify workers with chronic or recurring low back pain, using health history for reference. Fifty office workers of both sexes, aged between 19 and 55 yr, were evaluated using a standardized physical examination and the NMQ, VAS and RDQ. Discriminant analysis was performed to determine the discriminant properties of these instruments. A higher success rate (94%) was observed in the model including only the NMQ and in the model including the NMQ and the physical examination. The lowest success rate (82%) was observed in the model including the NMQ, RDQ and VAS. The NMQ was able to detect subjects with chronic or recurring low back pain with 100% sensitivity and 88% specificity. The NMQ appears to be the best instrument for identifying subjects with chronic or recurring low back pain. Thus, this self-reported questionnaire is suitable for screening workers for chronic or recurring low back pain in occupational settings. PMID:25810448

  1. Intact brain processing of musical emotions in autism spectrum disorder, but more cognitive load and arousal in happy vs. sad music

    PubMed Central

    Gebauer, Line; Skewes, Joshua; Westphael, Gitte; Heaton, Pamela; Vuust, Peter

    2014-01-01

    Music is a potent source for eliciting emotions, but not everybody experience emotions in the same way. Individuals with autism spectrum disorder (ASD) show difficulties with social and emotional cognition. Impairments in emotion recognition are widely studied in ASD, and have been associated with atypical brain activation in response to emotional expressions in faces and speech. Whether these impairments and atypical brain responses generalize to other domains, such as emotional processing of music, is less clear. Using functional magnetic resonance imaging, we investigated neural correlates of emotion recognition in music in high-functioning adults with ASD and neurotypical adults. Both groups engaged similar neural networks during processing of emotional music, and individuals with ASD rated emotional music comparable to the group of neurotypical individuals. However, in the ASD group, increased activity in response to happy compared to sad music was observed in dorsolateral prefrontal regions and in the rolandic operculum/insula, and we propose that this reflects increased cognitive processing and physiological arousal in response to emotional musical stimuli in this group. PMID:25076869

  2. Loading is more effective than posture in lumbar spinal stenosis: a study with a treadmill equipment.

    PubMed

    Oğuz, Hasan; Levendoğlu, Funda; Oğün, Tunç Cevat; Tantuğ, Aysenur

    2007-07-01

    The objective of this study was to assess the correlation between neurogenic intermittent claudication (NIC) in LSS and different positions as well as loading status, using the treadmill device. The study was a prospective clinical trial on lumbar spinal stenosis (LSS) using a treadmill equipment. The study population comprised of 80 LSS patients with a mean age of 61. The equipment included a treadmill, unloading station and loading vests. The patients were instructed to walk in five different positions. The initiation time of symptoms and total walking time were recorded. The examination was stopped after 20 min or at the onset of severe symptoms. In order to obtain pretest demographic data on subjects, visual analog scale, Roland-Morris questionnaire, pain disability index, and Beck depression index were used. The initiation time of symptoms (ITS) and total walking time (TWT) were measured during the test. Unloading provided a longer and loading a shorter ITS and TWT. Decline or incline positions did not affect ITS or TWT. The changes in posture had no correlation with the appearance of symptoms in LSS patients with NIC on a treadmill in this study, rather ITS and TWT were determined by axial loading and unloading. PMID:17273837

  3. Magnetoencephalography in Fronto-Parietal Opercular Epilepsy

    PubMed Central

    Kakisaka, Yosuke; Iwasaki, Masaki; Alexopoulos, Andreas V.; Enatsu, Rei; Jin, Kazutaka; Wang, Zhong I.; Mosher, John C.; Dubarry, Anne-Sophie; Nair, Dileep R.; Burgess, Richard C.

    2013-01-01

    Objective To clarify the clinical and neurophysiological profiles of fronto-parietal opercular epilepsy in which epileptic spikes are detected with magnetoencephalography (MEG) but not with scalp electroencephalography (EEG). Methods Four patients presented with epileptic spikes localized to the fronto-parietal opercular cortex, which were only appreciated following MEG recordings. Results In all cases, seizure semiology suggested early activation of the operculum and lower peri-rolandic cortex consistent with the somatotopic organization of this region, i.e. tingling sensation involving the throat and hemi-face or contralateral upper limb, and spasms of the neck and throat. MEG spikes were localized in the fronto-parietal operculum. Three of the four patients underwent invasive electrocorticography and/or stereo-EEG recordings, and spikes were confirmed to arise from the estimated area of MEG dipole localization. Two patients remained seizure-free for over 1 year after resection of the epileptogenic region; the other patient declined resective surgery due to proximity to the language cortex. Conclusion This study demonstrates the usefulness of MEG in localizing spikes arising from within the fronto-parietal opercular regions, and implies that MEG may provide localizing information in patients with symptoms suggestive of opercular epilepsy, even if scalp EEG recordings fail to disclose any epileptogenic activities. PMID:22658720

  4. Nonsurgical Korean Integrative Treatments for Symptomatic Lumbar Spinal Stenosis: A Three-Armed Randomized Controlled Pilot Trial Protocol

    PubMed Central

    Kim, Kiok; Shin, Kyung-Min; Lee, Jun-Hwan; Seo, Bok-Nam; Jung, So-Young; Youn, Yousuk; Lee, Sang Ho; Kim, Jaehong; Qu, Wenchun

    2016-01-01

    This is a study protocol for a pilot three-armed randomized controlled trial on nonsurgical integrative Korean medicinal treatment for symptomatic lumbar spinal stenosis (LSS). Thirty-six participants who have been diagnosed with (LSS) and recommended for spinal surgery by neurosurgeons or orthopedics and have had spinal symptoms such as severe low back pain and neurological claudication regardless of at least three months of conservative treatments will be recruited. Participants will be randomly assigned to be one of the three intervention groups, including the Mokhuri treatment program group 1 or 2 or usual care group. All treatments will be administered in inpatient units over a period of 4 weeks. The primary outcomes are 0 to 100 Visual Analogue Scales for low back pain and leg pain and the secondary outcomes are Oswestry Disability Index; EQ-5D; Roland-Morris Disability Questionnaire; Oxford Claudication Score; physical function test, including treadmill test, walking duration, and distance assessment for free leg pain; radiologic testing; and adverse events which will be assessed during the 4-week treatment period as well as after 3 and 6 months of follow-up. Then, we will assess the feasibility of the clinical trial design as well as a nonsurgical integrative treatment program. This trial is registered with CRIS registration number: KCT0001218. PMID:26941823

  5. Functional Connectivity of the Caudal Anterior Cingulate Cortex Is Decreased in Autism

    PubMed Central

    Zhou, Yuanyue; Shi, Lijuan; Cui, Xilong; Wang, Suhong; Luo, Xuerong

    2016-01-01

    The anterior cingulate cortex (ACC) is frequently reported to have functionally distinct sub-regions that play key roles in different intrinsic networks. However, the contribution of the ACC, which is connected to several cortical areas and the limbic system, to autism is not clearly understood, although it may be involved in dysfunctions across several distinct but related functional domains. By comparing resting-state fMRI data from persons with autism and healthy controls, we sought to identify the abnormalities in the functional connectivity (FC) of ACC sub-regions in autism. The analyses found autism-related reductions in FC between the left caudal ACC and the right rolandic operculum, insula, postcentral gyrus, superior temporal gyrus, and the middle temporal gyrus. The FC (z-scores) between the left caudal ACC and the right insula was negatively correlated with the Stereotyped Behaviors and Restricted Interests scores of the autism group. These findings suggest that the caudal ACC is recruited selectively in the pathomechanism of autism. PMID:26985666

  6. Atlas of Great Comets

    NASA Astrophysics Data System (ADS)

    Stoyan, Ronald; Dunlop, Storm

    2015-01-01

    Foreword; Using this book; Part I. Introduction: Cometary beliefs and fears; Comets in art; Comets in literature and poetry; Comets in science; Cometary science today; Great comets in antiquity; Great comets of the Middle Ages; Part II. The 30 Greatest Comets of Modern Times: The Great Comet of 1471; Comet Halley 1531; The Great Comet of 1556; The Great Comet of 1577; Comet Halley, 1607; The Great Comet of 1618; The Great Comet of 1664; Comet Kirch, 1680; Comet Halley, 1682; The Great Comet of 1744; Comet Halley, 1759; Comet Messier, 1769; Comet Flaugergues, 1811; Comet Halley, 1835; The Great March Comet of 1843; Comet Donati, 1858; Comet Tebbutt, 1861; The Great September Comet of 1882; The Great January Comet of 1910; Comet Halley, 1910; Comet Arend-Roland, 1956; Comet Ikeya-Seki, 1965; Comet Bennett, 1970; Comet Kohoutek, 1973-4; Comet West, 1976; Comet Halley, 1986; Comet Shoemaker-Levy 9, 1994; Comet Hyakutake, 1996; Comet Hale-Bopp, 1997; Comet McNaught, 2007; Part III. Appendices; Table of comet data; Glossary; References; Photo credits; Index.

  7. Are prognostic indicators for poor outcome different for acute and chronic low back pain consulters in primary care?

    PubMed

    Grotle, Margreth; Foster, Nadine E; Dunn, Kate M; Croft, Peter

    2010-12-01

    Few studies have investigated whether prognostic indicators, which contribute to the transition from acute to chronic low back pain (LBP), are also those which contribute to continuing persistence of chronic LBP. We compared the contribution of physical, psychological and social indicators to predicting disability after one year between consulters with LBP of less than 3 months duration and more than 3 months duration. Data from two large prospective cohort studies of consecutive patients consulting with LBP in general practices were merged, providing complete data for 258 cases with acute/subacute LBP and 668 cases with chronic LBP at 12 months follow-up. There were significant differences between the two LBP groups in baseline characteristics and clinical course of disability, assessed by Roland Morris Disability Questionnaire, during the year of follow-up. Adjusted associations between potential prognostic indicators and disability at 12months were carried out in the two LBP subgroups. The final multivariable regression models showed that being non-employed, having widespread pain, a high level of Chronic Pain Grade, and catastrophising were the strongest prognostic indicators for disability at 12 months in both LBP groups. Fear of pain was significantly associated with disability in chronic LBP. Importantly, beyond baseline disability, the effect size of the other prognostic indicators for poor outcome was rather low. These findings must continue to challenge researchers to identify useful early predictors of outcome in persons with disabling back pain, as screening and targeted treatment approaches are dependent upon prognostic indicators with clinical significance. PMID:20932646

  8. Use of conventional and alternative treatment strategies for a case of low back pain in a F/A-18 aviator

    PubMed Central

    Green, Bart N; Sims, John; Allen, Rachel

    2006-01-01

    Background Low back pain can diminish jet pilot concentration and function during flight and be severe enough to ground pilots or cause decreased flying time. The objective of this case report is to present an example of the integration of chiropractic care with conventional treatments for the management of low back pain in a F/A-18 aviator. Case presentation The patient had insidious severe low back pain without radiation or neurological deficit, resulting in 24 hours of hospitalization. Spinal degeneration was discovered upon imaging. Four months later, it still took up to 10 minutes for him to get out of bed and several minutes to exit the jet due to stiffness and pain. He had discontinued his regular Marine Corps fitness training due to pain avoidance. Pain severity ranged from 1.5–7.1 cm on a visual analog scale. His Roland Morris Disability Questionnaire score was 5 out of 24. The pilot's pain was managed with the coordinated efforts of the flight surgeon, physiatrist, physical therapist, and doctor of chiropractic. Following this regimen he had no pain and no functional disability; he was able to fly multiple training missions per week and exercise to Marine Corps standards. Conclusion A course of care integrating flight medicine, chiropractic, physical therapy, and physiatry appeared to alleviate pain and restore function to this F/A-18 aviator with low back pain. PMID:16820063

  9. Epilepsy, cognitive deficits and neuroanatomy in males with ZDHHC9 mutations

    PubMed Central

    Baker, Kate; Astle, Duncan E; Scerif, Gaia; Barnes, Jessica; Smith, Jennie; Moffat, Georgina; Gillard, Jonathan; Baldeweg, Torsten; Raymond, F Lucy

    2015-01-01

    Objective Systematic investigation of individuals with intellectual disability after genetic diagnosis can illuminate specific phenotypes and mechanisms relevant to common neurodevelopmental disorders. We report the neurological, cognitive and neuroanatomical characteristics of nine males from three families with loss-of-function mutations in ZDHHC9 (OMIM #300799). Methods All known cases of X-linked intellectual disability (XLID) due to ZDHHC9 mutation in the United Kingdom were invited to participate in a study of neurocognitive and neuroimaging phenotypes. Results Seven out of nine males with ZDHHC9 mutations had been diagnosed with epilepsy, exceeding epilepsy risk in XLID comparison subjects (P = 0.01). Seizure histories and EEG features amongst ZDHHC9 mutation cases shared characteristics with rolandic epilepsy (RE). Specific cognitive deficits differentiated males with ZDHHC9 mutations from XLID comparison subjects and converged with reported linguistic and nonlinguistic deficits in idiopathic RE: impaired oromotor control, reduced verbal fluency, and impaired inhibitory control on visual attention tasks. Consistent neuroanatomical abnormalities included thalamic and striatal volume reductions and hypoplasia of the corpus callosum. Interpretation Mutations in ZDHHC9 are associated with susceptibility to focal seizures and specific cognitive impairments intersecting with the RE spectrum. Neurocognitive deficits are accompanied by consistent abnormalities of subcortical structures and inter-hemispheric connectivity. The biochemical, cellular and network-level mechanisms responsible for the ZDHHC9-associated neurocognitive phenotype may be relevant to cognitive outcomes in RE. PMID:26000327

  10. Tuning Fragility: The Quest for Strong Polymeric Glass Formers

    NASA Astrophysics Data System (ADS)

    Erwin, Brian; Colby, Ralph; Lizotte, Jeremy; Long, Timothy

    2001-03-01

    Angell [1] has defined fragility m from the temperature dependence of relaxation time τ at the glass transition temperature T_g: m≡ [ dlog τ /d( T_g/T) ] _T=T_g. The strongest glass formers (e.g., silica) have m=16-20 and the most fragile glass formers are typically polymers, with m>100. Recent work [2] has reported that the fragility of polystyrene decreases as chain length is lowered, with a range 70Roland, J. Non-Cryst. Solids QTRbf275, 153 (2000). [3] R. H. Colby, Phys. Rev. E QTRbf61, 1783 (2000).

  11. The Five Factors of personality and regional cortical variability in the Baltimore Longitudinal Study of Aging

    PubMed Central

    Sutin, Angelina; Davatzikos, Christos; Costa, Paul; Resnick, Susan

    2012-01-01

    Although personality changes have been associated with brain lesions and atrophy caused by neurodegenerative diseases and aging, neuroanatomical correlates of personality in healthy individuals and their stability over time have received relatively little investigation. In this study, we explored regional gray matter (GM) volumetric associations of the five-factor model of personality. Eighty-seven healthy older adults took the NEO Personality Inventory and had brain MRI at two time points 2 years apart. We performed GM segmentation followed by regional analysis of volumes examined in normalized space map creation and voxel based morphometry-type statistical inference in SPM8. We created a regression model including all five factors and important covariates. Next, a conjunction analysis identified associations between personality scores and GM volumes that were replicable across time, also using cluster-level Family-Wise-Error correction. Larger right orbitofrontal and dorsolateral prefrontal cortices and rolandic operculum were associated with lower Neuroticism; larger left temporal, dorsolateral prefrontal, and anterior cingulate cortices with higher Extraversion; larger right frontopolar and smaller orbitofrontal and insular cortices with higher Openness; larger right orbitofrontal cortex with higher Agreeableness; larger dorsolateral prefrontal and smaller frontopolar cortices with higher Conscientiousness. In summary, distinct personality traits were associated with stable individual differences in GM volumes. As expected for higher-order traits, regions performing a large number of cognitive and affective functions were implicated. Our findings highlight personality-related variation that may be related to individual differences in brain structure that merit additional attention in neuroimaging research. PMID:22610513

  12. Relativistic Astrophysics

    NASA Astrophysics Data System (ADS)

    Jones, Bernard J. T.; Markovic, Dragoljub

    1997-06-01

    Preface; Prologue: Conference overview Bernard Carr; Part I. The Universe At Large and Very Large Redshifts: 2. The size and age of the Universe Gustav A. Tammann; 3. Active galaxies at large redshifts Malcolm S. Longair; 4. Observational cosmology with the cosmic microwave background George F. Smoot; 5. Future prospects in measuring the CMB power spectrum Philip M. Lubin; 6. Inflationary cosmology Michael S. Turner; 7. The signature of the Universe Bernard J. T. Jones; 8. Theory of large-scale structure Sergei F. Shandarin; 9. The origin of matter in the universe Lev A. Kofman; 10. New guises for cold-dark matter suspects Edward W. Kolb; Part II. Physics and Astrophysics Of Relativistic Compact Objects: 11. On the unification of gravitational and inertial forces Donald Lynden-Bell; 12. Internal structure of astrophysical black holes Werner Israel; 13. Black hole entropy: external facade and internal reality Valery Frolov; 14. Accretion disks around black holes Marek A. Abramowicz; 15. Black hole X-ray transients J. Craig Wheeler; 16. X-rays and gamma rays from active galactic nuclei Roland Svensson; 17. Gamma-ray bursts: a challenge to relativistic astrophysics Martin Rees; 18. Probing black holes and other exotic objects with gravitational waves Kip Thorne; Epilogue: the past and future of relativistic astrophysics Igor D. Novikov; I. D. Novikov's scientific papers and books.

  13. Common pediatric epilepsy syndromes.

    PubMed

    Park, Jun T; Shahid, Asim M; Jammoul, Adham

    2015-02-01

    Benign rolandic epilepsy (BRE), childhood idiopathic occipital epilepsy (CIOE), childhood absence epilepsy (CAE), and juvenile myoclonic epilepsy (JME) are some of the common epilepsy syndromes in the pediatric age group. Among the four, BRE is the most commonly encountered. BRE remits by age 16 years with many children requiring no treatment. Seizures in CAE also remit at the rate of approximately 80%; whereas, JME is considered a lifelong condition even with the use of antiepileptic drugs (AEDs). Neonates and infants may also present with seizures that are self-limited with no associated psychomotor disturbances. Benign familial neonatal convulsions caused by a channelopathy, and inherited in an autosomal dominant manner, have a favorable outcome with spontaneous resolution. Benign idiopathic neonatal seizures, also referred to as "fifth-day fits," are an example of another epilepsy syndrome in infants that carries a good prognosis. BRE, CIOE, benign familial neonatal convulsions, benign idiopathic neonatal seizures, and benign myoclonic epilepsy in infancy are characterized as "benign" idiopathic age-related epilepsies as they have favorable implications, no structural brain abnormality, are sensitive to AEDs, have a high remission rate, and have no associated psychomotor disturbances. However, sometimes selected patients may have associated comorbidities such as cognitive and language delay for which the term "benign" may not be appropriate. PMID:25658216

  14. On the nature of the anti-tail of Comet Kohoutek /1973f/. II - Comparison of the working model with ground-based photographic observations

    NASA Technical Reports Server (NTRS)

    Sekanina, Z.; Miller, F. D.

    1976-01-01

    On the basis of photographic observations made at the Cerro Tololo Inter-American Observatory, the radial and transverse brightness profiles and time variations in the surface brightness of the anti-tail of Comet Kohoutek were examined. In the process of photometric reduction one-dimensional radial tracings passing through the comet's nucleus and covering the entire anti-tail were used in the place of the standard two-dimensional scans. Each radial scan was defined by the position angle, and 'noise' variations were interpolated from the known field brightness outside the anti-tail. An analysis of the results provides quantitative support for a previously proposed model (Sekanina, 1974) suggesting that the dust particles in the anti-tail suffered a significant loss in radius due to evaporation near the perihelion passage. Preliminary calculations indicate that only particles initially larger than 100-150 micrometers in diameter survived. The emission rate of dust may be comparable to those derived for Comets Arend-Roland (1957 III) and Bennett (1970 II).

  15. The clinical and biomechanical effects of fascial-muscular lengthening therapy on tight hip flexor patients with and without low back pain

    PubMed Central

    Avrahami, Daniel; Potvin, Jim R.

    2014-01-01

    Background: Many patients have tight hip flexors with or without low back pain. Manual fascial-muscular lengthening therapy (FMLT) is one commonly used treatment for this population. Objective: Investigate the clinical and biomechanical effects of manual FMLT on tight hip flexor patients with and without low back pain. Methods: A nonrandomized trial, before-and-after experiment with multiple baselines conducted on two different patient populations: 1) Mechanical low back pain patients with tight hip flexors (n = 10) and 2) Asymptomatic group with tight hip flexors (n = 8). Four treatments of manual FMLT were performed on the hip flexor of the two groups of patients over a two-week period. Primary outcome measures over the two-week period were 1) Maximum voluntary trunk flexor and extensor moments, 2) Disability (Roland Morris Disability Questionnaire) and pain (10-cm Visual Analogue Scale), 3) Passive hip extension mobility. Results: Primary outcome analysis involved within-groups comparisons. Maximum voluntary trunk extension demonstrated increases for the low back pain patients. The low back pain patients demonstrated a small, but significant, reduction in disability and pain. Both groups demonstrated an increase in passive hip extension measurements. Conclusion: This preliminary study demonstrated interesting results from manual FMLT on two tight hip flexor patient populations with and without low back pain. However, there were several significant limitations from this study, which restrict the ability to generalize the results. PMID:25550670

  16. With Weekly Astronomy Tips Against the Weekly Papers' Astrology Humbug

    NASA Astrophysics Data System (ADS)

    Szécsényi-Nagy, G. A.

    2006-08-01

    The true democracy - following a long lasting monolithic political-cultural system of the so-called Peoples' Democracy -- freed the sluices in the early nineties for any absurd written idea. No really powerful newspapers or widely circulated magazines were allowed to publish any destructive astrological advice during those 40 years. Although here and there, somehow, it appeared cloaked but was unable to reach the wide public. The first signs of these unwanted changes reached our nation through the electronic media (first of all television, of course ) but very soon a whirl of everyday astrology has occupied a substantial part of almost every newspaper.This situation urges professional and amateur astronomers, astrophysicists, as well as other skeptic scientists and journalists to set their face against any ideas of pseudo-science. In our country, the most has been done by the Hungarian Astronomical Association and the Roland Eötvös Physical Society.I intend to call the attention of our colleagues from other countries and regions to these brave initiatives, and inform them on some useful steps and their first results. I also expect a vivid exchange of the opinions and strategies that can build and develop a wiser society in the over-industrialized or consuming-oriented countries

  17. Long-term safety and effectiveness of tanezumab as treatment for chronic low back pain.

    PubMed

    Gimbel, Joseph S; Kivitz, Alan J; Bramson, Candace; Nemeth, Mary Anne; Keller, David S; Brown, Mark T; West, Christine R; Verburg, Kenneth M

    2014-09-01

    A noncontrolled, randomized, multicenter study (NCT00924664) evaluated long-term safety and effectiveness of tanezumab in patients with chronic low back pain following a randomized placebo- and active-controlled parent study that evaluated analgesic efficacy. Patients were randomized to tanezumab 10mg (n=321) or 20mg (n=527) administered at 8-week intervals via 3 intravenous injections followed by 4 subcutaneous injections. Effectiveness analyses included change from parent study baseline in Brief Pain Inventory Short Form, Roland Morris Disability Questionnaire, and Patient's Global Assessment of low back pain. Safety assessments included adverse event documentation, physical/neurological examinations, and laboratory tests. Mean treatment duration during the extension study was 194 and 202 days with tanezumab 10 and 20mg, respectively. Both tanezumab doses provided similar and sustained improvements in all effectiveness outcomes. The most frequently reported adverse events were arthralgia, paresthesia, and hypoesthesia. Adverse events initially described as osteonecrosis were reported in 6 patients (tanezumab 10mg, n=2; tanezumab 20mg, n=4); 9 additional patients (tanezumab 10mg, n=7; tanezumab 20mg, n=2) underwent total joint replacement (TJR). A blinded, independent adjudication committee reviewed all 6 patients with reported osteonecrosis and 4 of the 9 patients undergoing TJR. Adjudication outcomes were osteonecrosis (n=0), worsening osteoarthritis (n=5; 1 rapidly progressive), and another diagnosis or indeterminate (n=5). Tanezumab 10mg had better tolerability than tanezumab 20mg, and may represent an effective long-term treatment for chronic low back pain. PMID:24937440

  18. Neurobiological Changes of Schizotypy: Evidence From Both Volume-Based Morphometric Analysis and Resting-State Functional Connectivity

    PubMed Central

    Wang, Yi; Yan, Chao; Yin, Da-zhi; Fan, Ming-xia; Cheung, Eric F. C.; Pantelis, Christos; Chan, Raymond C. K.

    2015-01-01

    The current study sought to examine the underlying brain changes in individuals with high schizotypy by integrating networks derived from brain structural and functional imaging. Individuals with high schizotypy (n = 35) and low schizotypy (n = 34) controls were screened using the Schizotypal Personality Questionnaire and underwent brain structural and resting-state functional magnetic resonance imaging on a 3T scanner. Voxel-based morphometric analysis and graph theory-based functional network analysis were conducted. Individuals with high schizotypy showed reduced gray matter (GM) density in the insula and the dorsolateral prefrontal gyrus. The graph theoretical analysis showed that individuals with high schizotypy showed similar global properties in their functional networks as low schizotypy individuals. Several hubs of the functional network were identified in both groups, including the insula, the lingual gyrus, the postcentral gyrus, and the rolandic operculum. More hubs in the frontal lobe and fewer hubs in the occipital lobe were identified in individuals with high schizotypy. By comparing the functional connectivity between clusters with abnormal GM density and the whole brain, individuals with high schizotypy showed weaker functional connectivity between the left insula and the putamen, but stronger connectivity between the cerebellum and the medial frontal gyrus. Taken together, our findings suggest that individuals with high schizotypy present changes in terms of GM and resting-state functional connectivity, especially in the frontal lobe. PMID:25533270

  19. A global wave parameter database for geophysical applications. Part 2: Model validation with improved source term parameterization

    NASA Astrophysics Data System (ADS)

    Rascle, Nicolas; Ardhuin, Fabrice

    2013-10-01

    A multi-scale global hindcast of ocean waves is presented that covers the years 1994-2012, based on recently published parameterizations for wind sea and swell dissipation [Ardhuin, F., Rogers, E., Babanin, A., Filipot, J.-F., Magne, R., Roland, A., van der Westhuysen, A., Queffeulou, P., Lefevre, J.-M., Aouf, L., Collard, F., 2010. Semi-empirical dissipation source functions for wind-wave models: Part I. Definition, calibration and validation. J. Phys. Oceanogr. 40 (9), 1917-1941]. Results from this hindcast include traditional wave parameters, like the significant wave height and mean periods, and we particularly consider the accuracy of the results for phenomenal sea states, with significant heights above 14 m. Using unbiased winds, there is no evidence of a bias in wave heights even for this very high range. Various spectral moments were also validated, including the surface Stokes drift and mean square slopes that are relevant for wave-current interactions modelling and remote sensing, and also spectra of seismic noise sources. The estimation of these parameters is made more accurate by the new wave growth and dissipation parameterizations. Associated air-sea fluxes of momentum and energy are significantly different from what is obtained with the WAM-Cycle 4 parameterization, with a roughness that is practically a function of wind speed only. That particular output of the model does not appear very realistic and will require future adjustments of the generation and dissipation parameterizations.

  20. Cerebral gray matter volume variation in female-to-male transsexuals: a voxel-based morphometric study.

    PubMed

    Kim, Tae-Hoon; Kim, Seok-Kwun; Jeong, Gwang-Woo

    2015-12-16

    Several studies seem to support the hypothesis that brain anatomy is associated with transsexualism. However, these studies were still limited because few neuroanatomical findings have been obtained from female-to-male (FtM) transsexuals. This study compared the cerebral regional volumes of gray matter (GM) between FtM transsexuals and female controls using a voxel-based morphometry. Twelve FtM transsexuals who had undergone sex-reassignment surgery and 15 female controls participated in this study. Both groups were age matched and right-handed, with no history of neurological illness. Fifteen female controls were recruited to determine whether GM volumes in FtM transsexuals more closely resembled individuals who shared their biological sex. MRI data were processed using SPM 8 with the diffeomorphic anatomical registration through exponentiated Lie algebra (DARTEL). FtM transsexuals showed significantly larger volumes of the thalamus, hypothalamus, midbrain, gyrus rectus, head of caudate nucleus, precentral gyrus, and subcallosal area compared with the female controls. However, the female controls showed a significantly larger volume in the superior temporal gyrus including Heschl's gyrus and Rolandic operculum. These findings confirm that the volume difference in brain substructures in FtM transsexuals is likely to be associated with transsexualism and that transsexualism is probably associated with distinct cerebral structures, determining gender identity. PMID:26559725

  1. A practical approach to uncomplicated seizures in children.

    PubMed

    McAbee, G N; Wark, J E

    2000-09-01

    Uncomplicated seizures and epilepsy are common in infants and children. Family physicians should be aware of certain epilepsy syndromes that occur in children, such as febrile seizures, benign focal epilepsy of childhood, complex partial epilepsy, juvenile myoclonic epilepsy and video game-related epilepsy. Not all uncomplicated childhood seizures require neuroimaging or treatment. Febrile seizures, rolandic seizures and video game-related seizures are childhood epileptic syndromes that are typically not associated with brain structural lesions on computed tomography or magnetic resonance imaging, and are often not treated with anticonvulsant drugs. Juvenile myoclonic epilepsy does not require neuroimaging but does require treatment because of a high rate of recurrent seizures. Complex partial epilepsy often requires both neuroimaging and treatment. Although seizures are diagnosed primarily on clinical grounds, all children with a possible seizure (except febrile seizures) should have an electroencephalogram. Interictal EEGs may be normal. Computed tomography has demonstrated abnormalities in 7 to 19 percent of children with new-onset seizures. The yield of magnetic resonance imaging for specific childhood seizure types is not known, but it is the preferred modality of neuroimaging for many clinical presentations. Most children's seizures treated with anticonvulsants are controlled by the first drug selected. The value of "therapeutic' serum drug levels is questionable in the management of uncomplicated childhood seizures. PMID:10997534

  2. Nonsurgical Korean Integrative Treatments for Symptomatic Lumbar Spinal Stenosis: A Three-Armed Randomized Controlled Pilot Trial Protocol.

    PubMed

    Kim, Kiok; Shin, Kyung-Min; Lee, Jun-Hwan; Seo, Bok-Nam; Jung, So-Young; Youn, Yousuk; Lee, Sang Ho; Kim, Jaehong; Qu, Wenchun; Kim, Tae-Hun

    2016-01-01

    This is a study protocol for a pilot three-armed randomized controlled trial on nonsurgical integrative Korean medicinal treatment for symptomatic lumbar spinal stenosis (LSS). Thirty-six participants who have been diagnosed with (LSS) and recommended for spinal surgery by neurosurgeons or orthopedics and have had spinal symptoms such as severe low back pain and neurological claudication regardless of at least three months of conservative treatments will be recruited. Participants will be randomly assigned to be one of the three intervention groups, including the Mokhuri treatment program group 1 or 2 or usual care group. All treatments will be administered in inpatient units over a period of 4 weeks. The primary outcomes are 0 to 100 Visual Analogue Scales for low back pain and leg pain and the secondary outcomes are Oswestry Disability Index; EQ-5D; Roland-Morris Disability Questionnaire; Oxford Claudication Score; physical function test, including treadmill test, walking duration, and distance assessment for free leg pain; radiologic testing; and adverse events which will be assessed during the 4-week treatment period as well as after 3 and 6 months of follow-up. Then, we will assess the feasibility of the clinical trial design as well as a nonsurgical integrative treatment program. This trial is registered with CRIS registration number: KCT0001218. PMID:26941823

  3. The Effects of VR-based Wii Fit Yoga on Physical Function in Middle-aged Female LBP Patients

    PubMed Central

    Kim, Seong-Sik; Min, Won-Kyu; Kim, Jung-Hee; Lee, Byoung-Hee

    2014-01-01

    [Purpose] The purpose of this research was to determine the effects of a virtual reality-based yoga program on middle-aged female low back pain patients. [Subjects and Methods] Thirty middle-aged female patients who suffered from low back pain were assigned to either a physical therapy program or a virtual reality-based yoga program for a period of four weeks. Participants could check their posture and weight bearing on a monitor as they shifted their weight or changed their postures on a Wii balance board. There were a total of seven exercise programs. A 30-minute, three times per week, virtual reality-based Wii Fit yoga program or trunk stabilizing exercise was performed, respectively. [Results] Repeated-measures analysis of covariance revealed significant differences in between pre- and post-training VAS, algometer, Oswestry low-back pain disability index (ODI), Roland Morris disability questionnaire (RMDQ), and fear avoidance beliefs questionnaire (FBQ) scores. The VAS, algometer, ODI, RMDQ, and FBQ scores showed significant differences in groups. Regarding the effect of time-by-group interaction, there were significant differences in VAS, ODI, ODI, and FBQ scores. [Conclusion] In conclusion, for middle-aged female patients who have low back pain, a virtual reality-based yoga program was shown to have positive effects on physical improvements, and this program can be employed as a therapeutic medium for prevention and cure of low back pain. PMID:24764631

  4. Development of Sampling Techniques For Planetary Surfaces

    NASA Astrophysics Data System (ADS)

    Coste, P.; Eiden, M.; Gromov, V.; Ilykorpi, T.; Kochan, H.; Re, E.; Richter, L.

    During the last 15 years, the European Space Agency has initiated the development of a number of sampling techniques for planetary surfaces, in the frame of its basic Technology and Research Programme (TRP). Sampling may be performed by means of drilling, coring, milling, grain scooping or picking, and penetration. The items addressed in particular are: the Sample Acquisition System (SAS) for the late Comet Nucleus Sample and Return mission; the Small Sample Acquisition and Distribution Tool (SSA/DT): the Mole and the Sampling Mole (SM). Some of these devices have found a direct application within an ESA planetary mission, as expected; in other cases, their concept was used and modified to fulfill updated requirements. Sampling or soil probing capabilities are included to various extents in these current or near-future ESA missions: the Huygens Probe (on NASA's CASSINI spacecraft), on its way to Titan surface; the RoLand Lander (on ROSETTA s/c), onto Comet Wirtanen; the Beagle2 Lander (carried by MARS EXPRESS s/c) sampling the Martian surface and sub- surface. Future sampling missions to Mercury, the Moon and to asteroids are being studied. Even more challenging missions to Venus are considered.

  5. Efficacy of movement control exercises versus general exercises on recurrent sub-acute nonspecific low back pain in a sub-group of patients with movement control dysfunction. protocol of a randomized controlled trial

    PubMed Central

    2012-01-01

    Background Practice guidelines recommend various types of exercise for chronic back pain but there have been few head-to-head comparisons of these interventions. General exercise seems to be an effective option for management of chronic low back pain (LBP) but very little is known about the management of a sub-acute LBP within sub-groups. Recent research has developed clinical tests to identify a subgroup of patients with chronic non-specific LBP who have movement control dysfunction (MD). Method/Design We are conducting a randomized controlled trial (RCT) to compare the effects of general exercise and specific movement control exercise (SMCE) on disability and function in patients with MD within recurrent sub-acute LBP. The main outcome measure is the Roland Morris Disability Questionnaire. Discussion European clinical guideline for management of chronic LBP recommends that more research is required to develop tools to improve the classification and identification of specific clinical sub-groups of chronic LBP patients. Good quality RCTs are then needed to determine the effectiveness of specific interventions aimed at these specific target groups. This RCT aims to test the hypothesis whether patients within a sub-group of MD benefit more through a specific individually tailored movement control exercise program than through general exercises. PMID:22494776

  6. Dipolar Effects in an Ultracold Gas of LiCs Molecules

    NASA Astrophysics Data System (ADS)

    Weidemueller, Matthias

    2011-05-01

    Recently, there has been important progress in the investigation of ultracold polar molecules in the absolute ground state, thus opening intriguing perspectives for strongly correlated quantum systems under the influence of long-range dipolar forces. We have studied the formation of LiCs molecules via photoassociation (PA) in a double-species magneto-optical trap. The LiCs dimer is a particularly promising candidate for observing dipolar effects, as it possesses the largest dipole moment of all alkali dimers (5.5 Debye in the ground state). Ultracold LiCs molecules in the absolute rovibrational ground state are formed by a single photo-association step. The dipole moment of ground state levels is determined by Stark spectroscopy and was found to be in excellent agreement with the theoretical predictions. Vibrational redistribution due to spontaneous emission and blackbody radiation is observed and compared a rate-equation model.In collaboration with Johannes Deiglmayr, Marc Repp, University of Heidelberg; Roland Wester, University of Innsbruck; and Olivier Dulieu, Laboratoire Aime Cotton. Work was supported by DFG and ESF in the framework of the Eurocores EuroQUAM as well as the Heidelberg Center for Quantum Dynamics.

  7. Sleep and Epilepsy: Strange Bedfellows No More.

    PubMed

    St Louis, Erik K

    2011-09-01

    Ancient philosophers and theologians believed that altered consciousness freed the mind to prophesy the future, equating sleep with seizures. Only recently has the bidirectional influences of epilepsy and sleep upon one another received more substantive analysis. This article reviews the complex and increasingly recognized interrelationships between sleep and epilepsy. NREM sleep differentially activates interictal epileptiform discharges during slow wave (N3) sleep, while ictal seizure events occur more frequently during light NREM stages N1 and N2. The most commonly encountered types of sleep-related epilepsies (those with preferential occurrence during sleep or following arousal) include frontal and temporal lobe partial epilepsies in adults, and benign epilepsy of childhood with centrotemporal spikes (benign rolandic epilepsy) and juvenile myoclonic epilepsy in children and adolescents. Comorbid sleep disorders are frequent in patients with epilepsy, particularly obstructive sleep apnea in refractory epilepsy patients which may aggravate seizure burden, while treatment with nasal continuous positive airway pressure often improves seizure frequency. Distinguishing nocturnal events such as NREM parasomnias (confusional arousals, sleep walking, and night terrors), REM parasomnias including REM sleep behavior disorder, and nocturnal seizures if frequently difficult and benefits from careful history taking and video-EEG-polysomnography in selected cases. Differentiating nocturnal seizures from primary sleep disorders is essential for determining appropriate therapy, and recognizing co-existent sleep disorders in patients with epilepsy may improve their seizure burden and quality of life. PMID:23539488

  8. When Is EEG Indicated in Attention-Deficit/Hyperactivity Disorder?

    PubMed

    Zaimoğlu, Sennur; Türkdoğan, Dilşad; Mazlum, Betül; Bekiroğlu, Nural; Tetik-Kabil, Aylin; Eyilikeder, Seda

    2015-11-01

    The authors investigated the parameters for predicting epileptiform abnormalities in a group of children diagnosed with attention-deficit/hyperactivity disorder (ADHD). The sample consisted of 148 subjects aged between 6 and 13 (8.76 ± 1.26; 25.7% female) years. Subtypes of ADHD and comorbid psychiatric disorders were defined according to DSM-IV criteria. The Wechsler Intelligence Scale for Children-Revised was applied to all patients. Most of the subjects (89.2%) had wakefulness and sleep electroencephalography examinations lasting about one hour. The authors found out that the coexistence of speech sound disorder (odds ratio [OR] 3.90, 95% confidence interval [CI]: 1.61-9.48) and higher Digit Span test performance (OR 1.24, 95% CI: 1.06-1.44) predicted the presence of accompanying epileptiform abnormalities. The prevalence of epileptiform abnormalities was 26.4%, and they were frequently localized in the frontal (41%) and centrotemporal (28.2%) regions. Higher percentage of speech sound disorder co-occurrence (64%) in subjects with rolandic spikes suggests that epileptiform abnormalities associated with ADHD can be determined genetically at least in some cases. Pathophysiology of epileptiform abnormalities in ADHD might have complex genetic and maturational background. PMID:25895916

  9. Comparison between Kinesio Taping and a Traditional Physical Therapy Program in Treatment of Nonspecific Low Back Pain.

    PubMed

    Kachanathu, Shaji John; Alenazi, Aqeel M; Seif, Hamada Eid; Hafez, Ashraf Ramadan; Alroumim, Meshari Abdulmohsen

    2014-08-01

    [Purpose] Nonspecific low back pain (NSLBP) is a very common but largely self-limiting condition. Several types of tape and their associated application methods are available for different conditions. The aim of the present study was to observe the effect of Kinesio taping (KT) compared with traditional management of NSLBP. [Subjects and Methods] Forty male and female patients with a mean age of 34.8±7.54 years were randomly divided into two groups; group 1 (n=20) which underwent conventional physical therapy with KT, and group 2 (n=20), which underwent only conventional physical therapy. The intervention sessions for both groups were three times per week for four weeks. Outcomes were assessed for activities of daily living (ADL) using the Roland-Morris Disability Questionnaire, pain severity using a visual analogue scale, and ranges of motion (ROMs) of trunk flexion and extension using the modified Schober's test. [Results] Significant differences in measures of pain, ADL, and trunk flexion and extension ROMs were observed post intervention within each group. In comparison, there were no significant differences in measures of pain, ADL, and trunk flexion and extension ROMs post intervention between groups. [Conclusion] A physical therapy program involving strengthening exercises for abdominal muscles and stretching exercises for back, hamstring, and iliopsoas muscles with or without Kinesio taping was beneficial in the treatment of chronic low back pain. PMID:25202177

  10. Towards a functional neuroanatomy of conscious perception and its modulation by volition: implications of human auditory neuroimaging studies.

    PubMed Central

    Silbersweig, D A; Stern, E

    1998-01-01

    Conscious sensory perception and its modulation by volition are integral to human mental life. Functional neuroimaging techniques provide a direct means of identifying and characterizing in vivo the systems-level patterns of brain activity associated with such mental functions. In a series of positron emission tomography activation experiments, we and our colleagues have examined a range of normal and abnormal auditory states that, when contrasted, provide dissociations relevant to the question of the neural substrates of sensory awareness. These dissociations include sensory awareness in the presence and absence of external sensory stimuli, the transition from sensory unawareness to awareness (or vice versa) in the presence of sensory stimuli, and sensory awareness with and without volition. The auditory states studied include hallucinations, mental imagery, cortical deafness modulated by attention, and hearing modulated by sedation. The results of these studies highlight the distributed nature of the functional neuroanatomy that is sufficient, if not necessary, for sensory awareness. The probable roles of unimodal association (as compared with primary) cortices, heteromodal cortices, limbic/paralimbic regions and subcortical structures (such as the thalamus) are discussed. In addition, interactions between pre- and post-rolandic regions are examined in the context of top-down, volitional modulation of sensory awareness. PMID:9854260

  11. Relation of Obesity to Consummatory and Anticipatory Food Reward

    PubMed Central

    Stice, Eric; Spoor, Sonja; Ng, Janet; Zald, David H.

    2009-01-01

    This report reviews findings from studies that have investigated whether abnormalities in reward from food intake and anticipated food intake increase risk for obesity. Self-report and behavioral data suggest that obese relative to lean individuals show elevated anticipatory and consumatory food reward. Brain imaging studies suggest that obese relative to lean individuals show greater activation of the gustatory cortex (insula/frontal operculum) and oral somatosensory regions (parietal operculum and Rolandic operculum) in response to anticipated intake and consumption of palatable foods. Yet, data also suggest that obese relative to lean individuals show less activation in the dorsal striatum in response to consumption of palatable foods and reduced striatal D2 dopamine receptor density. Emerging prospective data also suggest that abnormal activation in these brain regions increases risk for future weight gain and that genotypes associated with lowered dopamine signaling amplify these predictive effects. Results imply that individuals who show greater activation in the gustatory cortex and somatosensory regions in response to anticipation and consumption of food, but who show weaker activation in the striatum during food intake, may be at risk for overeating, particularly those at genetic risk for lowered dopamine receptor signaling. PMID:19328819

  12. Intact brain processing of musical emotions in autism spectrum disorder, but more cognitive load and arousal in happy vs. sad music.

    PubMed

    Gebauer, Line; Skewes, Joshua; Westphael, Gitte; Heaton, Pamela; Vuust, Peter

    2014-01-01

    Music is a potent source for eliciting emotions, but not everybody experience emotions in the same way. Individuals with autism spectrum disorder (ASD) show difficulties with social and emotional cognition. Impairments in emotion recognition are widely studied in ASD, and have been associated with atypical brain activation in response to emotional expressions in faces and speech. Whether these impairments and atypical brain responses generalize to other domains, such as emotional processing of music, is less clear. Using functional magnetic resonance imaging, we investigated neural correlates of emotion recognition in music in high-functioning adults with ASD and neurotypical adults. Both groups engaged similar neural networks during processing of emotional music, and individuals with ASD rated emotional music comparable to the group of neurotypical individuals. However, in the ASD group, increased activity in response to happy compared to sad music was observed in dorsolateral prefrontal regions and in the rolandic operculum/insula, and we propose that this reflects increased cognitive processing and physiological arousal in response to emotional musical stimuli in this group. PMID:25076869

  13. Girl with a PRRT2 mutation and infantile focal epilepsy with bilateral spikes.

    PubMed

    Torisu, Hiroyuki; Watanabe, Kyoko; Shimojima, Keiko; Sugawara, Midori; Sanefuji, Masafumi; Ishizaki, Yoshito; Sakai, Yasunari; Yamashita, Hironori; Yamamoto, Toshiyuki; Hara, Toshiro

    2014-04-01

    This paper documents the case of a female Japanese patient with infantile focal epilepsy, which was different from benign infantile seizures, and a family history of infantile convulsion and paroxysmal choreoathetosis. The patient developed partial seizures (e.g., psychomotor arrest) at age 14 months. At the time of onset, interictal electroencephalography (EEG) showed bilateral parietotemporal spikes, but the results of neurologic examination and brain magnetic resonance imaging were normal. Her seizures were well controlled with carbamazepine, and she had a normal developmental outcome. EEG abnormalities, however, persisted for more than 6 years, and the spikes moved transiently to the occipital area and began to resemble the rolandic spikes recognized in benign childhood epilepsy. Her father had paroxysmal kinesigenic dyskinesia, with an onset age of 6 years, and her youngest sister had typical benign infantile seizures. Genetic analysis demonstrated that all affected members had a heterozygous mutation of c.649_650insC in the proline-rich transmembrane protein-2 (PRRT2) gene. This case indicates that the phenotypic spectrum of infantile seizures or epilepsy with PRRT2-related pathology may be larger than previously expected, and that genetic investigation of the effect of PRRT2 mutations on idiopathic seizures or epilepsy in childhood may help elucidate the pathological backgrounds of benign childhood epilepsy. PMID:23768507

  14. General Aspects

    NASA Astrophysics Data System (ADS)

    Höfle, Gerhard

    Epothilone is a microbial product, and thus its history may be traced back to the discovery of the respective microbe, Sorangium cellulosum, a bacterium belonging to the taxonomic group of myxobacteria, which originally has been described by Roland Thaxter in 1892 (1). Today this group of organisms comprises around 40 species, one of which is Sorangium cellulosum. For a long time, myxobacteria were only known for their gliding motility and sophisticated life cycle, although it had been occasionally speculated that they might produce secondary metabolites like actinomycetes or bacilli (2). In 1975 Hans Reichenbach and his group at the German Centre for Biotechnology (GBF; now called the Helmholtz Centre for Infection Research) set out to isolate strains of myxobacteria from soil samples collected all over the world, and to examine their secondary metabolism. In 1978, while work was already ongoing, I joined them and took over the chemistry part. In the same year the first structure of a myxobacterial metabolite, ambruticin, was published by a group from Warner-Lambert (3) making us very confident of being on the right track. Ambruticin had been isolated from a Sorangium cellulosum strain, and was identified as a unique cyclopropane polyketide structure exhibiting potentially useful antifungal properties. Ambruticin and its derivatives had been developed for medical application for some time, and recently gained new interest (4).

  15. Human annoyance and reactions to hotel room specific noises

    NASA Astrophysics Data System (ADS)

    Everhard, Ian L.

    2001-05-01

    A new formula is presented where multiple annoyance sources and transmission loss values of any partition are combined to produce a new single number rating of annoyance. The explanation of the formula is based on theoretical psychoacoustics and survey testing used to create variables used to weight the results. An imaginary hotel room is processed through the new formula and is rated based on theoretical survey results that would be taken by guests of the hotel. The new single number rating compares the multiple sources of annoyance to a single imaginary unbiased source where absolute level is the only factor in stimulating a linear rise in annoyance [Fidell et al., J. Acoust. Soc. Am. 66, 1427 (1979); D. M. Jones and D. E. Broadbent, ``Human performance and noise,'' in Handbook of Noise Control, 3rd ed., edited by C. M. Harris (ASA, New York, 1998), Chap. 24; J. P. Conroy and J. S. Roland, ``STC Field Testing and Results,'' in Sound and Vibration Magazine, Acoustical Publications, pp. 10-15 (July 2003)].

  16. Efficacy of transforaminal versus interspinous corticosteroid injectionin discal radiculalgia - a prospective, randomised, double-blind study.

    PubMed

    Thomas, E; Cyteval, C; Abiad, L; Picot, M C; Taourel, P; Blotman, F

    2003-10-01

    A prospective, randomised, double-blind study was carried out to compare the respective efficacies of transforaminal and interspinous epidural corticosteroid injections in discal radiculalgia. Thirty-one patients (18 females, 13 males) with discal radicular pain of less than 3 months' duration were consecutively randomised to receive either radio-guided transforaminal or blindly performed interspinous epidural corticosteroid injections. Post-treatment outcome was evaluated clinically at 6 and 30 days, and then at 6 months, but only by mailed questionnaire. At day 6, the between-group difference was significantly in favour of the transforaminal group with respect to Schober's index, finger-to-floor distance, daily activities, and work and leisure activities on the Dallas pain scale. At day 30, pain relief was significantly better in the transforaminal group. At month 6, answers to the mailed questionnaire still showed significantly better results for transforaminal injection concerning pain, daily activities, work and leisure activities and anxiety and depression, with a decline in the Roland-Morris score. In recent discal radiculalgia, the efficacy of radio-guided transforaminal epidural corticosteroid injections was higher than that obtained with blindly-performed interspinous injections. PMID:14579160

  17. Abnormal cortical sensorimotor activity during “Target” sound detection in subjects with acute acoustic trauma sequelae: an fMRI study

    PubMed Central

    Job, Agnès; Pons, Yoann; Lamalle, Laurent; Jaillard, Assia; Buck, Karl; Segebarth, Christoph; Delon-Martin, Chantal

    2012-01-01

    The most common consequences of acute acoustic trauma (AAT) are hearing loss at frequencies above 3 kHz and tinnitus. In this study, we have used functional Magnetic Resonance Imaging (fMRI) to visualize neuronal activation patterns in military adults with AAT and various tinnitus sequelae during an auditory “oddball” attention task. AAT subjects displayed overactivities principally during reflex of target sound detection, in sensorimotor areas and in emotion-related areas such as the insula, anterior cingulate and prefrontal cortex, in premotor area, in cross-modal sensory associative areas, and, interestingly, in a region of the Rolandic operculum that has recently been shown to be involved in tympanic movements due to air pressure. We propose further investigations of this brain area and fine middle ear investigations, because our results might suggest a model in which AAT tinnitus may arise as a proprioceptive illusion caused by abnormal excitability of middle-ear muscle spindles possibly link with the acoustic reflex and associated with emotional and sensorimotor disturbances. PMID:22574285

  18. Impact of O/sub 3/ on winter wheat yield (CSRCLAP)

    SciTech Connect

    Not Available

    1984-01-01

    The present study was initiated to provide further biological response data suitable for evaluating ambient air quality standards and for use in the NCLAN economic assessment of the consequences of O/sub 3/ exposure to crops. Specifically, the objective was to establish exposure-response relationships between yield of two important cultivars of soft red winter wheat (both examined in 1982) grown in the Midwest and chronic exposures to a range of O/sub 3/ concentrations. The O/sub 3/ sensitivity was somewhat less in 1983 than it had been in 1982. It may be that the conditions of excess moisture and high fertility allowed the plants to overcome the O/sub 3/ stress at near ambient concentrations. Alternatively, the data on Heggestad suggest that moisture stress may potentiate O/sub 3/ effects at near ambient concentrations. Our 1982 wheat may have been under moderate moisture stress and thus was more sensitive to ambient O/sub 3/. Winter wheat (Abe and Arthur-71) is still to be considered as more sensitive than grain sorghum or field corn and less sensitive than soybean. The cultivar Roland, however, is more sensitive than Corsoy soybean. 7 references, 4 figures, 4 tables.

  19. Abnormal cortical sensorimotor activity during "Target" sound detection in subjects with acute acoustic trauma sequelae: an fMRI study.

    PubMed

    Job, Agnès; Pons, Yoann; Lamalle, Laurent; Jaillard, Assia; Buck, Karl; Segebarth, Christoph; Delon-Martin, Chantal

    2012-03-01

    The most common consequences of acute acoustic trauma (AAT) are hearing loss at frequencies above 3 kHz and tinnitus. In this study, we have used functional Magnetic Resonance Imaging (fMRI) to visualize neuronal activation patterns in military adults with AAT and various tinnitus sequelae during an auditory "oddball" attention task. AAT subjects displayed overactivities principally during reflex of target sound detection, in sensorimotor areas and in emotion-related areas such as the insula, anterior cingulate and prefrontal cortex, in premotor area, in cross-modal sensory associative areas, and, interestingly, in a region of the Rolandic operculum that has recently been shown to be involved in tympanic movements due to air pressure. We propose further investigations of this brain area and fine middle ear investigations, because our results might suggest a model in which AAT tinnitus may arise as a proprioceptive illusion caused by abnormal excitability of middle-ear muscle spindles possibly link with the acoustic reflex and associated with emotional and sensorimotor disturbances. PMID:22574285

  20. Savage poetry: torture and cruelty in Mirbeau and Barbey d'Aurevilly.

    PubMed

    Thompson, Hannah

    2010-01-01

    Octave Mirbeau's Le Jardin des supplices and Barbey d'Aurevilly's L'Ensorcelée and Les Diaboliques depict a range of cruel attacks on the human body. These examples of violence, hitherto neglected by critical readers of the texts, have much to tell us not only about the authors' approach to violence, but also about the relationships between author, reader, and text that such representations of violence foreground. The notion of readerly pleasure theorized by Roland Barthes and linked to identity formation by Emma Wilson is associated with the witnessing or experiencing of pain in these texts. The reader is problematically positioned as both sadist, vicariously enjoying the suffering he or she is forced to witness, and masochist, taking pleasure in the authors' manipulations of them. These depictions of violated bodies ask whether and by what means violence can be represented in language, and this discussion leads to an analysis of the impact that such representations of violence have on the reader's experience of a text. PMID:21114062

  1. Extending the phenotypic spectrum of RBFOX1 deletions: Sporadic focal epilepsy.

    PubMed

    Lal, Dennis; Pernhorst, Katharina; Klein, Karl Martin; Reif, Philipp; Tozzi, Rossana; Toliat, Mohammad R; Winterer, Georg; Neubauer, Bernd; Nürnberg, Peter; Rosenow, Felix; Becker, Felicitas; Lerche, Holger; Kunz, Wolfram S; Kurki, Mitja I; Hoffmann, Per; Becker, Albert J; Perucca, Emilio; Zara, Federico; Sander, Thomas; Weber, Yvonne G

    2015-09-01

    Partial deletions of the RBFOX1 gene encoding the neuronal splicing regulator have been reported in a range of neurodevelopmental diseases including idiopathic/genetic generalized epilepsy (IGE/GGE), childhood focal epilepsy, and self-limited childhood benign epilepsy with centrotemporal spikes (BECTS, rolandic epilepsy), and autism. The protein regulates alternative splicing of many neuronal transcripts involved in the homeostatic control of neuronal excitability. Herein, we examined whether structural deletions affecting RBFOX1 exons confer susceptibility to common forms of juvenile and adult focal epilepsy syndromes. We screened 807 unrelated patients with sporadic focal epilepsy, and we identified seven hemizygous exonic RBFOX1 deletions in patients with sporadic focal epilepsy (0.9%) in comparison to one deletion found in 1,502 controls. The phenotypes of the patients carrying RBFOX1 deletions comprise magnetic resonance imaging (MRI)-negative epilepsy of unknown etiology with frontal and temporal origin (n = 5) and two patients with temporal lobe epilepsy with hippocampal sclerosis. The epilepsies were largely pharmacoresistant but not associated with intellectual disability. Our study extends the phenotypic spectrum of RBFOX1 deletions as a risk factor for focal epilepsy and suggests that exonic RBFOX1 deletions are involved in the broad spectrum of focal and generalized epilepsies. PMID:26174448

  2. Approach for a Global Height Reference System

    NASA Astrophysics Data System (ADS)

    Ihde, Johannes

    2015-04-01

    Hermann Drewes, Christoph Foerste, Thomas Gruber, Gunter Liebsch, Roland Pail, Laura Sanchez For Earth system monitoring the heights are main parameters for global changes. Physical heights are potential differences of the outer Earth gravity field at different positions. Long term monitoring of the vertical component of the Earth surface needs a standardized defined and realized global reference relating the geometry and the gravity field of the Earth. In the last two decades, in several working groups of the International Association of Geodesy were different concepts for definition and realization of global height reference system discussed. Furthermore, the satellite gravity missions have the Earth gravity field data basis general extended. So far, it is possible to develop the present local and regional height reference systems concepts to a global approach. The presented proposal has to be understood as a model that consider the present possibilities and actual needs for the realization of a global height reference system. It includes aspects for the combination of observations and products representing the geometry and the gravity field of the Earth.

  3. PREFACE: International Conference "Trends in Spintronics and Nanomagnetism" (TSN-2010)

    NASA Astrophysics Data System (ADS)

    Maruccio, Giuseppe; Sanvito, Stefano; Hoffmann, Germar; Wiesendanger, Roland; Rowan, Alan

    2011-03-01

    Dublin, Ireland), Germar Hoffmann and Roland Wiesendanger (Institute for Applied Physics, University of Hamburg, Germany), and Alan Rowan (NSRIM Institute Radboud University Nijmegen, The Netherlands). This group also acted as the Publication Committee and managed all the submitted papers that were reviewed by expert referees in order to meet the standards of the Journal of Physics: Conference Series. Conference photographNobel Laureate A Fert with some members of the organizing committee. The conference would not have been possible without the support from the local organizing committee at the University of Salento and NNL Institute Nanoscience-CNR, including Anna Paola Caricato, Luigi Martina and the Conference Secretaries Maria Concetta Gerardi, Adriana Amato, and Gabriella Zammillo. We are grateful for the technical assistance of Michele Linciano, Antonio Guerrieri, Carmine Mangia, Luciano Carluccio, and Tommaso Moscara e Francesco Sabetta. We also gratefully acknowledge Serena Chiriacó, Anna Grazia Mondeduro and Massimo Corrado who helped to run the conference. The conference was made possible by the financial support from the European Commission through the SpiDME project (EU-FP6-029002), the Italian Ministry for Foreign Affairs, the University of Lecce and its Department of Physics, and all of the sponsors (Lot Oriel, Attocube, Schaefer, Cryogenic Ltd, Oxford Instruments, MTI Corporation, Cantele, Monte dei Paschi di Siena). Conference Chair and Co-Chairs Giuseppe MaruccioStefano SanvitoGermar HoffmannRoland WiesendangerAlan Rowan Logos

  4. Cortical reorganization in recent-onset tinnitus patients by the Heidelberg Model of Music Therapy

    PubMed Central

    Krick, Christoph M.; Grapp, Miriam; Daneshvar-Talebi, Jonas; Reith, Wolfgang; Plinkert, Peter K.; Bolay, Hans Volker

    2015-01-01

    Pathophysiology and treatment of tinnitus still are fields of intensive research. The neuroscientifically motivated Heidelberg Model of Music Therapy, previously developed by the German Center for Music Therapy Research, Heidelberg, Germany, was applied to explore its effects on individual distress and on brain structures. This therapy is a compact and fast application of nine consecutive 50-min sessions of individualized therapy implemented over 1 week. Clinical improvement and long-term effects over several years have previously been published. However, the underlying neural basis of the therapy's success has not yet been explored. In the current study, the therapy was applied to acute tinnitus patients (TG) and healthy active controls (AC). Non-treated patients were also included as passive controls (PTC). As predicted, the therapeutic intervention led to a significant decrease of tinnitus-related distress in TG compared to PTC. Before and after the study week, high-resolution MRT scans were obtained for each subject. Assessment by repeated measures design for several groups (Two-Way ANOVA) revealed structural gray matter (GM) increase in TG compared to PTC, comprising clusters in precuneus, medial superior frontal areas, and in the auditory cortex. This pattern was further applied as mask for general GM changes as induced by the therapy week. The therapy-like procedure in AC also elicited similar GM increases in precuneus and frontal regions. Comparison between structural effects in TG vs. AC was calculated within the mask for general GM changes to obtain specific effects in tinnitus patients, yielding GM increase in right Heschl's gyrus, right Rolandic operculum, and medial superior frontal regions. In line with recent findings on the crucial role of the auditory cortex in maintaining tinnitus-related distress, a causative relation between the therapy-related GM alterations in auditory areas and the long-lasting therapy effects can be assumed. PMID:25745385

  5. Cortical reorganization in recent-onset tinnitus patients by the Heidelberg Model of Music Therapy.

    PubMed

    Krick, Christoph M; Grapp, Miriam; Daneshvar-Talebi, Jonas; Reith, Wolfgang; Plinkert, Peter K; Bolay, Hans Volker

    2015-01-01

    Pathophysiology and treatment of tinnitus still are fields of intensive research. The neuroscientifically motivated Heidelberg Model of Music Therapy, previously developed by the German Center for Music Therapy Research, Heidelberg, Germany, was applied to explore its effects on individual distress and on brain structures. This therapy is a compact and fast application of nine consecutive 50-min sessions of individualized therapy implemented over 1 week. Clinical improvement and long-term effects over several years have previously been published. However, the underlying neural basis of the therapy's success has not yet been explored. In the current study, the therapy was applied to acute tinnitus patients (TG) and healthy active controls (AC). Non-treated patients were also included as passive controls (PTC). As predicted, the therapeutic intervention led to a significant decrease of tinnitus-related distress in TG compared to PTC. Before and after the study week, high-resolution MRT scans were obtained for each subject. Assessment by repeated measures design for several groups (Two-Way ANOVA) revealed structural gray matter (GM) increase in TG compared to PTC, comprising clusters in precuneus, medial superior frontal areas, and in the auditory cortex. This pattern was further applied as mask for general GM changes as induced by the therapy week. The therapy-like procedure in AC also elicited similar GM increases in precuneus and frontal regions. Comparison between structural effects in TG vs. AC was calculated within the mask for general GM changes to obtain specific effects in tinnitus patients, yielding GM increase in right Heschl's gyrus, right Rolandic operculum, and medial superior frontal regions. In line with recent findings on the crucial role of the auditory cortex in maintaining tinnitus-related distress, a causative relation between the therapy-related GM alterations in auditory areas and the long-lasting therapy effects can be assumed. PMID:25745385

  6. The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): first annual report.

    PubMed

    de By, Theo M M H; Mohacsi, Paul; Gummert, Jan; Bushnaq, Hasan; Krabatsch, Thomas; Gustafsson, Finn; Leprince, Pascal; Martinelli, Luigi; Meyns, Bart; Morshuis, Michiel; Netuka, Ivan; Potapov, Evgenij; Zittermann, Armin; Delmo Walter, Eva Maria; Hetzer, Roland

    2015-05-01

    The European Registry for Patients with Mechanical Circulatory Support (EUROMACS) was founded on 10 December 2009 with the initiative of Roland Hetzer (Deutsches Herzzentrum Berlin, Berlin, Germany) and Jan Gummert (Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Germany) with 15 other founding international members. It aims to promote scientific research to improve care of end-stage heart failure patients with ventricular assist device or a total artificial heart as long-term mechanical circulatory support. Likewise, the organization aims to provide and maintain a registry of device implantation data and long-term follow-up of patients with mechanical circulatory support. Hence, EUROMACS affiliated itself with Dendrite Clinical Systems Ltd to offer its members a software tool that allows input and analysis of patient clinical data on a daily basis. EUROMACS facilitates further scientific studies by offering research groups access to any available data wherein patients and centres are anonymized. Furthermore, EUROMACS aims to stimulate cooperation with clinical and research institutions and with peer associations involved to further its aims. EUROMACS is the only European-based Registry for Patients with Mechanical Circulatory Support with rapid increase in institutional and individual membership. Because of the expeditious data input, the European Association for Cardiothoracic Surgeons saw the need to optimize the data availability and the significance of the registry to improve care of patients with mechanical circulatory support and its potential contribution to scientific intents; hence, the beginning of their alliance in 2012. This first annual report is designed to provide an overview of EUROMACS' structure, its activities, a first data collection and an insight to its scientific contributions. PMID:25820161

  7. Brainwave signatures--an index reflective of the brain's functional neuroanatomy: further findings on the effect of EEG sensorimotor rhythm biofeedback training on the neurologic precursors of learning disabilities.

    PubMed

    Tansey, M A

    1985-11-01

    Eight boys, ages 7 years 11 months to 15 years 3 months, were provided with long-term--symptom duration--sensorimotor rhythm biofeedback training for the remediation of their learning disabilities. Concurrently, the simultaneous recording of five frequency bands of brainwave activity (5 Hz, 7 Hz, 10 Hz, 12 Hz and 14 Hz), from one active electrode equidistant from reference and ground, was intended to provide a glimpse of the 'brainwave signature' reflective of the dynamic and synergistic processes involved in such cerebro-neural activation and the brain's global response to such an alteration in the sensorimotor subnetwork. Overall, the main effect of this procedure, for the biofeedback and subsequent conditioning of increased 14 Hz neural discharge patterns over the central Rolandic cortex in a clinical office setting, seems to be to increase bilateral sensorimotor transactions resulting in substantive remediation of the learning disabilities of the recipients of such training--by way of internally exercising of, and/or recruitment of additional neural activation within, the sensorimotor subnetwork/matrix. Observation of the changing brainwave signatures showed a tendency for decreased slow wave activity concomitant with increases in fast wave activity, for cases with a Full Scale I.Q. within the range of 76 and 85; with those cases with a Full Scale I.Q. within the range of 102 and 116 exhibiting increased amplitudes over most of the monitored bands, but with the increases being much less at the slower frequencies. It is noteworthy that those four subjects with either a significant Verbal greater than Performance, or Performance greater than Verbal, I.Q. Score discrepancy exhibited no less than a 40% greater increase in the lower of the two I.Q. scores; indicating that this SMR training procedure also resulted in an increased symmetry in the interhemispheric interactions reflective of the higher cortical functions for these no longer learning disabled boys. PMID

  8. A Randomized, Single-Blind, Placebo-Controlled Study on the Efficacy of the Arthrokinematic Approach-Hakata Method in Patients with Chronic Nonspecific Low Back Pain

    PubMed Central

    Kogure, Akira; Kotani, Kazuhiko; Katada, Shigehiko; Takagi, Hiroshi; Kamikozuru, Masahiro; Isaji, Takashi; Hakata, Setsuo

    2015-01-01

    Study design cized, single-blind, controlled trial. Objective To investigate the efficacy of the Arthrokinematic approach (AKA)-Hakata (H) method for chronic low back pain. Summary of Background Data The AKA-H method is used to manually treat abnormalities of intra-articular movement. Methods One hundred eighty-six patients with chronic nonspecific low back pain randomly received either the AKA-H method (AKA-H group) or the sham technique (S group) monthly for 6 months. Data were collected at baseline and once a month. Outcome measures were pain intensity (visual analogue scale [VAS]) and quality of life (the Roland-Morris Disability Questionnaire [RDQ] and Short Form SF-36 questionnaire [SF-36]). Results At baseline, the VAS, RDQ, and SF-36 scores showed similar levels between the groups. After 6 months, the AKA-H group had more improvement in the VAS (42.8% improvement) and RDQ score (31.1% improvement) than the sham group (VAS: 10.4% improvement; RDQ: 9.8% improvement; both, P < 0.001). The respective scores for the SF-36 subscales (physical functioning, role physical, bodily pain, social functioning, general health perception, role emotional, and mental health) were also significantly more improved in the AKA-H group than in the sham group (all, P < 0.001). The scores for the physical, psychological, and social aspects of the SF-36 subscales showed similar improvement in the AKA-H group. Conclusion The AKA-H method can be effective in managing chronic low back pain. Trial Registration UMIN Clinical Trials Registry (UMIN-CTR) UMIN000006250. PMID:26646534

  9. Kinesio Taping® is not better than placebo in reducing pain and disability in patients with chronic non-specific low back pain: a randomized controlled trial

    PubMed Central

    Luz, Maurício A.; Sousa, Manoel V.; Neves, Luciana A. F. S.; Cezar, Aline A. C.; Costa, Leonardo O. P.

    2015-01-01

    Background: Kinesio Taping ® has been widely used in clinical practice. However, it is unknown whether this type of tape is more effective than placebo taping in patients with chronic lower back pain. Objective: To compare the effectiveness of Kinesio Taping ® in patients with chronic non-specific low back pain against a placebo tape and a control group. Method: This is a 3-arm, randomized controlled trial with a blinded assessor. Sixty patients with chronic non-specific low back pain were randomized into one of the three groups: Kinesio Taping ® group (n=20), Micropore® (placebo) group (n=20) and control group (n=20). Patients allocated to both the Kinesio Taping ® group and the placebo group used the different types of tape for a period of 48 hours. The control group did not receive any intervention. The outcomes measured were pain intensity (measured by an 11-point numerical rating scale) and disability (measured by the 24-item Roland Morris Disability Questionnaire). A blinded assessor measured the outcomes at baseline, 48 hours and 7 days after randomization. Results: After 48 hours, there was a statistically significant difference between the Kinesio Taping ® group versus the control group (mean between-group difference = -3.1 points, 95% CI=-5.2 to -1.1, p=0.003), but no difference when compared to the placebo group (mean between-group difference= 1.9 points, 95% CI=-0.2 to 3.9, p=0.08). For the other outcomes no differences were observed. Conclusions: The Kinesio Taping ® is not better than placebo (Micropore®) in patients with chronic low back pain. PMID:26647750

  10. Auricular acupuncture for primary care treatment of low back pain and posterior pelvic pain in pregnancy: study protocol for a multicentre randomised placebo-controlled trial

    PubMed Central

    2014-01-01

    Background About 45% of all pregnant women suffer low back pain and/or pelvic girdle pain (LBPGP). This study seeks to evaluate the effect of auricular acupuncture on LBPGP compared with placebo auricular acupuncture and with standard obstetric care in the field of primary health care. Methods and design This study will be a four-parallel-arm, multicentre, randomised, placebo-controlled trial. A total of 212 pregnant women (24 to 36 weeks’ gestation), aged at least 17 years, with LBPGP, will be randomly assigned to the verum auricular acupuncture plus standard obstetric care group (VAAc), to the non-specific auricular acupuncture plus standard obstetric care group (NSAAc), to the non-specific placebo auricular acupuncture plus standard obstetric care group (PAAc), or the standard obstetric care group (SOC). The VAAc, NSAAc, and PAAc groups will receive treatment at three auricular acupuncture points (specific points for the VAAc group or non-specific ones for the NSAAc and PAAc groups), once a week for 2 weeks; the SOC group will receive only standard obstetric care during the same period. The primary outcome will be the reduction in pain intensity, according to the visual analogue scale (iVAS), at 2 weeks after the start of treatment. The secondary outcomes will be functional status with respect to LBPGP (according to the Roland-Morris disability questionnaire), health-related quality of life (SF12) at 2 weeks after the start of treatment, and iVAS at 12 and 48 weeks postpartum. Discussion This trial will implement a high-quality methodology and may provide evidence for the efficacy, safety, and specificity of auricular acupuncture as a treatment for pregnant women with LBPGP. Trial registration Current Controlled Trials ISRCTN41033073 (date 20/03/2014). PMID:25027493