sORFs.org: a repository of small ORFs identified by ribosome profiling

PubMed Central

Olexiouk, Volodimir; Crappé, Jeroen; Verbruggen, Steven; Verhegen, Kenneth; Martens, Lennart; Menschaert, Gerben

2016-01-01

With the advent of ribosome profiling, a next generation sequencing technique providing a “snap-shot’’ of translated mRNA in a cell, many short open reading frames (sORFs) with ribosomal activity were identified. Follow-up studies revealed the existence of functional peptides, so-called micropeptides, translated from these ‘sORFs’, indicating a new class of bio-active peptides. Over the last few years, several micropeptides exhibiting important cellular functions were discovered. However, ribosome occupancy does not necessarily imply an actual function of the translated peptide, leading to the development of various tools assessing the coding potential of sORFs. Here, we introduce sORFs.org (http://www.sorfs.org), a novel database for sORFs identified using ribosome profiling. Starting from ribosome profiling, sORFs.org identifies sORFs, incorporates state-of-the-art tools and metrics and stores results in a public database. Two query interfaces are provided, a default one enabling quick lookup of sORFs and a BioMart interface providing advanced query and export possibilities. At present, sORFs.org harbors 263 354 sORFs that demonstrate ribosome occupancy, originating from three different cell lines: HCT116 (human), E14_mESC (mouse) and S2 (fruit fly). sORFs.org aims to provide an extensive sORFs database accessible to researchers with limited bioinformatics knowledge, thus enabling easy integration into personal projects. PMID:26527729

us-ipy.org - This website is for sale! - design cascading style sheets

Science.gov Websites

The owner of us-ipy.org is offering it for sale for an asking price of 499 USD! us-ipy.org Related Searches Sedo Logo This webpage was generated by the domain owner using Sedo Domain Parking. Disclaimer mark is not controlled by Sedo nor does it constitute or imply its association, endorsement or

A Kind of Optimization Method of Loading Documents in OpenOffice.org

NASA Astrophysics Data System (ADS)

Lan, Yuqing; Li, Li; Zhou, Wenbin

As a giant in open source community, OpenOffice.org has become the most popular office suite within Linux community. But OpenOffice.org is relatively slow while loading documents. Research shows that the most time consuming part is importing one page of whole document. If there are many pages in a document, the accumulation of time consumed can be astonishing. Therefore, this paper proposes a solution, which has improved the speed of loading documents through asynchronous importing mechanism: a document is not imported as a whole, but only part of the document is imported at first for display, then mechanism in the background is started to asynchronously import the remaining parts, and insert it into the drawing queue of OpenOffice.org for display. In this way, the problem can be solved and users don't have to wait for a long time. Application start-up time testing tool has been used to test the time consumed in loading different pages of documents before and after optimization of OpenOffice.org, then, we adopt the regression theory to analyse the correlation between the page number of documents and the loading time. In addition, visual modeling of the experimental data are acquired with the aid of matlab. An obvious increase in loading speed can be seen after a comparison of the time consumed to load a document before and after the solution is adopted. And then, using Microsoft Office compared with the optimized OpenOffice.org, their loading speeds are almost same. The results of the experiments show the effectiveness of this solution.

Making Research Data Repositories Visible: The re3data.org Registry

PubMed Central

Pampel, Heinz; Vierkant, Paul; Scholze, Frank; Bertelmann, Roland; Kindling, Maxi; Klump, Jens; Goebelbecker, Hans-Jürgen; Gundlach, Jens; Schirmbacher, Peter; Dierolf, Uwe

2013-01-01

Researchers require infrastructures that ensure a maximum of accessibility, stability and reliability to facilitate working with and sharing of research data. Such infrastructures are being increasingly summarized under the term Research Data Repositories (RDR). The project re3data.org–Registry of Research Data Repositories–has begun to index research data repositories in 2012 and offers researchers, funding organizations, libraries and publishers an overview of the heterogeneous research data repository landscape. In July 2013 re3data.org lists 400 research data repositories and counting. 288 of these are described in detail using the re3data.org vocabulary. Information icons help researchers to easily identify an adequate repository for the storage and reuse of their data. This article describes the heterogeneous RDR landscape and presents a typology of institutional, disciplinary, multidisciplinary and project-specific RDR. Further the article outlines the features of re3data.org, and shows how this registry helps to identify appropriate repositories for storage and search of research data. PMID:24223762

Guiametabolica.org: empowerment through internet tools in inherited metabolic diseases.

PubMed

Armayones, Manuel; Vilaseca, M Antònia; Cutillas, Júlia; Fàbrega, Jordi; Fernández, Jorge Juan; García, Mei; Egea, Natàlia; Pousada, Modesta; Gómez-Zuñiga, Beni; Pérez-Payarols, Jaume; Artuch, Rafael; Palau, Francesc; Serrano, Mercedes

2012-08-21

Web-based interventions are effective on the patient empowerment. Guiametabolica.org constitutes an interface for people involved in inherited metabolic diseases, trying to facilitate access to information and contact with professionals and other patients, offering a platform to develop support groups. Guiametabolica.org is widely considered for Spanish-speaking patients and caregivers with inherited metabolic diseases. Preliminary evaluations show changes in their habits, decrease in their senses of isolation and improvement regarding self-efficacy. Specific inherited metabolic diseases websites, especially participative websites, should be considered as a complement to more traditional clinical approaches. Their contribution lies in patient's general well-being, without interfering with traditional care.

Folkvine.org: Arts-Based Research on the Web

ERIC Educational Resources Information Center

Congdon, Kristin G.

2006-01-01

Folkvine.org is a website that presents seven Florida folk artists, three guidebooks, and several scholarly bobble heads that make commentary on humanities topics, the artists, and their work. This article analyzes the website as an arts-based research project. Topics covered address issues of representation, translation, learning processes, and…

CitSci.org: A New Model for Managing, Documenting, and Sharing Citizen Science Data

PubMed Central

Wang, Yiwei; Kaplan, Nicole; Newman, Greg; Scarpino, Russell

2015-01-01

Citizen science projects have the potential to advance science by increasing the volume and variety of data, as well as innovation. Yet this potential has not been fully realized, in part because citizen science data are typically not widely shared and reused. To address this and related challenges, we built CitSci.org (see www.citsci.org), a customizable platform that allows users to collect and generate diverse datasets. We hope that CitSci.org will ultimately increase discoverability and confidence in citizen science observations, encouraging scientists to use such data in their own scientific research. PMID:26492521

CitSci.org: A New Model for Managing, Documenting, and Sharing Citizen Science Data.

PubMed

Wang, Yiwei; Kaplan, Nicole; Newman, Greg; Scarpino, Russell

2015-10-01

Citizen science projects have the potential to advance science by increasing the volume and variety of data, as well as innovation. Yet this potential has not been fully realized, in part because citizen science data are typically not widely shared and reused. To address this and related challenges, we built CitSci.org (see www.citsci.org), a customizable platform that allows users to collect and generate diverse datasets. We hope that CitSci.org will ultimately increase discoverability and confidence in citizen science observations, encouraging scientists to use such data in their own scientific research.

Further characterization of the GlyT-1 inhibitor Org25935: anti-alcohol, neurobehavioral, and gene expression effects.

PubMed

Lidö, Helga Höifödt; Jonsson, Susanne; Hyytiä, Petri; Ericson, Mia; Söderpalm, Bo

2017-05-01

The glycine transporter-1 inhibitor Org25935 is a promising candidate in a treatment concept for alcohol use disorder targeting the glycine system. Org25935 inhibits ethanol-induced dopamine elevation in brain reward regions and reduces ethanol intake in Wistar rats. This study aimed to further characterise the compound and used ethanol consumption, behavioral measures, and gene expression as parameters to investigate the effects in Wistar rats and, as pharmacogenetic comparison, Alko-Alcohol (AA) rats. Animals were provided limited access to ethanol in a two-bottle free-choice paradigm with daily drug administration. Acute effects of Org25935 were estimated using locomotor activity and neurobehavioral status. Effects on gene expression in Wistar rats were measured with qPCR. The higher but not the lower dose of Org25935 reduced alcohol intake in Wistar rats. Unexpectedly, Org25935 reduced both ethanol and water intake and induced strong CNS-depressive effects in AA-rats (withdrawn from further studies). Neurobehavioral effects by Org25935 differed between the strains (AA-rats towards sedation). Org25935 did not affect gene expression at the mRNA level in the glycine system of Wistar rats. The data indicate a small therapeutic range for the anti-alcohol properties of Org25935, a finding that may guide further evaluations of the clinical utility of GlyT-1 inhibitors. The results point to the importance of pharmacogenetic considerations when developing drugs for alcohol-related medical concerns. Despite the lack of successful clinical outcomes, to date, the heterogeneity of drug action of Org25935 and similar agents and the unmet medical need justify further studies of glycinergic compounds in alcohol use disorder.

Narratives of experience of mental health and illness on healthtalk.org.

PubMed

Kidd, Jo; Ziebland, Sue

2016-10-01

Online health information is increasingly popular and may bring both benefits and potential harm to users with mental health problems. The encouragement of harmful behaviour among this population is a particular concern. The website healthtalk.org provides the benefits of shared experience by publishing excerpts from rigorous research interviews with patients, contextualised with medical information. This article sets out evidence for the positive and negative effects of online mental health information and describes the methodology behind healthtalk.org, with an overview of the mental health information it provides and how it can benefit patients and health professionals.

Narratives of experience of mental health and illness on healthtalk.org

PubMed Central

Kidd, Jo; Ziebland, Sue

2016-01-01

Online health information is increasingly popular and may bring both benefits and potential harm to users with mental health problems. The encouragement of harmful behaviour among this population is a particular concern. The website healthtalk.org provides the benefits of shared experience by publishing excerpts from rigorous research interviews with patients, contextualised with medical information. This article sets out evidence for the positive and negative effects of online mental health information and describes the methodology behind healthtalk.org, with an overview of the mental health information it provides and how it can benefit patients and health professionals. PMID:27752347

Geosamples.org: Shared Cyberinfrastructure for Geoscience Samples

NASA Astrophysics Data System (ADS)

Lehnert, Kerstin; Allison, Lee; Arctur, David; Klump, Jens; Lenhardt, Christopher

2014-05-01

Many scientific domains, specifically in the geosciences, rely on physical samples as basic elements for study and experimentation. Samples are collected to analyze properties of natural materials and features that are key to our knowledge of Earth's dynamical systems and evolution, and to preserve a record of our environment over time. Huge volumes of samples have been acquired over decades or even centuries and stored in a large number and variety of institutions including museums, universities and colleges, state geological surveys, federal agencies, and industry. All of these collections represent highly valuable, often irreplaceable records of nature that need to be accessible so that they can be re-used in future research and for educational purposes. Many sample repositories are keen to use cyberinfrastructure capabilities to enhance access to their collections on the internet and to support and streamline collection management (accessioning of new samples, labeling, handling sample requests, etc.), but encounter substantial challenges and barriers to integrate digital sample management into their daily routine. They lack the resources (staff, funding) and infrastructure (hardware, software, IT support) to develop and operate web-enabled databases, to migrate analog sample records into digital data management systems, and to transfer paper- or spreadsheet-based workflows to electronic systems. Use of commercial software is often not an option as it incurs high costs for licenses, requires IT expertise for installation and maintenance, and often does not match the needs of the smaller repositories, being designed for large museums or different types of collections (art, archeological, biological). Geosamples.org is an alliance of sample repositories (academic, US federal and state surveys, industry) and data facilities that aims to develop a cyberinfrastructure that will dramatically advance access to physical samples for the research community, government

Effect of the glucocorticoid receptor antagonist Org 34850 on basal and stress-induced corticosterone secretion.

PubMed

Spiga, F; Harrison, L R; Wood, S A; Atkinson, H C; MacSweeney, C P; Thomson, F; Craighead, M; Grassie, M; Lightman, S L

2007-11-01

The activity of the hypothalamic-pituitary-adrenal (HPA) axis is characterised both by an ultradian pulsatile pattern of glucocorticoid secretion and an endogenous diurnal rhythm. Glucocorticoid feedback plays a major role in regulating HPA axis activity and this mechanism occurs via two different receptors: mineralocorticoid (MR) and glucocorticoid receptors (GR). In the present study, the effects of both acute and subchronic treatment with the GR antagonist Org 34850 on basal and stress-induced HPA axis activity in male rats were evaluated. To investigate the effect of Org 34850 on basal diurnal corticosterone rhythm over the 24-h cycle, an automated blood sampling system collected samples every 10 min. Acute injection of Org 34850 (10 mg/kg, s.c.) did not affect basal or stress-induced corticosterone secretion, but was able to antagonise the inhibitory effect of the glucocorticoid agonist methylprednisolone on stress-induced corticosterone secretion. However, 5 days of treatment with Org 34850 (10 mg/kg, s.c., two times a day), compared to rats treated with vehicle (5% mulgofen in 0.9% saline, 1 ml/kg, s.c.), increased corticosterone secretion over the 24-h cycle and resulted in changes in the pulsatile pattern of hormone release, but had no significant effect on adrenocorticotrophic hormone secretion or on stress-induced corticosterone secretion. Subchronic treatment with Org 34850 did not alter GR mRNA expression in the hippocampus, paraventricular nucleus of the hypothalamus or anterior-pituitary, or MR mRNA expression in the hippocampus. Our data suggest that a prolonged blockade of GRs is required to increase basal HPA axis activity. The changes observed here with ORG 34850 are consistent with inhibition of GR-mediated negative feedback of the HPA axis. In light of the evidence showing an involvement of dysfunctional HPA axis in the pathophysiology of depression, Org 34850 could be a potential treatment for mood disorders.

Pharmacodynamic and pharmacokinetic effects of the intravenous CB1 receptor agonist Org 26828 in healthy male volunteers.

PubMed

Zuurman, Lineke; Passier, Paul C C M; de Kam, Marieke L; Kleijn, Huub J; Cohen, Adam F; van Gerven, Joop M A

2010-11-01

An ideal drug for outpatient treatments under conscious sedation would have both sedative and analgesic properties. CB1/CB2 agonists are expected to have sedative, amnestic, analgesic and anti-emetic properties. The main objective of this first study in humans was to assess the sedative properties of intravenous Org 26828. In addition, pharmacokinetics, amnestic properties, postural stability, and behavioural and cardiovascular effects were studied. Midazolam intravenous 0.1 mg/kg and placebo were used as controls. The pharmacokinetic parameters (Cmax and AUC0-inf) of the main metabolite Org 26761 were proportional to dose. No effects were observed after doses up to 0.3 μg/kg of Org 26828. Dose-related effects were observed at higher doses. Although subjects reported subjective sedation after administration of Org 26828 at 3 and 6 μg/kg, the observed sedation was considerably less than after midazolam. Doses higher than the maximum tolerated dose of 1 μg/kg of Org 26828 caused unpleasant central nervous system effects (anxiety, paranoia, hallucinations). Therefore, Org 26828 is not suitable for providing sedation for outpatient surgical procedures.

Evaluation of the phosphodiesterase 3 inhibitor ORG 9935 as a contraceptive in female macaques: initial trials.

PubMed

Jensen, Jeffrey T; Stouffer, Richard L; Stanley, Jessica E; Zelinski, Mary B

2010-02-01

The study was conducted to determine whether a phosphodiesterase (PDE) 3 inhibitor has potential as a novel contraceptive in primates. Regularly cycling adult female cynomolgus macaques of proven fertility (n=16) were treated for 7 months with placebo (controls) or the PDE3 inhibitor ORG 9935 as a daily food treat (150 mg/kg) or as a weekly depot injection (150 mg/kg, sc). After 1 month, a male of proven fertility was introduced into each group. Females underwent weekly monitoring of progesterone (P) and ultrasound evaluation for pregnancy if P remained elevated (1.0 ng/mL) >3 weeks. ORG 9935 values were evaluated using high-performance liquid chromatography. Overall, the pregnancy rate in ORG 9935-treated monkeys (4/8, 50%) did not differ from controls (7/8, 88%; p=.5). However, no animal became pregnant in a cycle when the serum level of ORG 9935 exceeded 300 nmol/L. Moreover, two treated monkeys who mated throughout the treatment phase and did not conceive became pregnant within four cycles after stopping ORG 9935. The other two animals were discontinued prematurely from the protocol. These results demonstrate that ORG 9935 may prevent pregnancy in primates at serum concentrations above 300 nmol/L and that the effect is reversible.

The glycine reuptake inhibitor org 25935 interacts with basal and ethanol-induced dopamine release in rat nucleus accumbens.

PubMed

Lidö, Helga Höifödt; Stomberg, Rosita; Fagerberg, Anne; Ericson, Mia; Söderpalm, Bo

2009-07-01

The mesolimbic dopamine (DA) projection from the ventral tegmental area to nucleus accumbens (nAc), a central part of the reward system, is activated by ethanol (EtOH) and other drugs of abuse. We have previously demonstrated that the glycine receptor in the nAc and its amino acid agonists may be implicated in the DA activation and reinforcing properties of EtOH. We have also reported that the glycine transporter 1 inhibitor, Org 25935, produces a robust and dose-dependent decrease in EtOH consumption in Wistar rats. The present study explores the interaction between EtOH and Org 25935 with respect to DA levels in the rat nAc. The effects of Org 25935 (6 mg/kg, i.p.) and/or EtOH (2.5 g/kg, i.p.) on accumbal DA levels were examined by means of in vivo microdialysis (coupled to HPLC-ED) in freely moving male Wistar rats. The effect of Org 25935 on accumbal glycine output was also investigated. Systemic Org 25935 increased DA output in a subpopulation of rats (52% in Experiment 1 and 38% in Experiment 2). In Experiment 2, EtOH produced a significant increase in DA levels in vehicles (35%) and in Org 25935 nonresponders (19%), whereas EtOH did not further increase the DA level in rats responding to Org 25935 (2%). The same dose of Org 25935 increased glycine levels by 87% in nAc. This study demonstrates that Org 25935, probably via increased glycine levels, (i) counteracts EtOH-induced increases of accumbal DA levels and (ii) increases basal DA levels in a subpopulation of rats. The results are in line with previous findings and it is suggested that the effects observed involve interference with accumbal GlyRs and are related to the alcohol consumption modulating effect of Org 25935.

4Kids.org: Topical, Searchable, and Safe Internet-Based Resource for Children and Youth

ERIC Educational Resources Information Center

Bacon, Melanie; Blood, Leslie; Ault, Marilyn; Adams, Doug

2008-01-01

4Kids.org is an online resource with an accompanying syndicated print publication created to promote safe access to websites and technology literacy. 4Kids.org, created by ALTEC at the University of Kansas in 1995, provides a variety of Internet-based activities as well as access to a database of websites reviewed for educational content,…

First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial.

PubMed

Rigby-Jones, Ann E; Sneyd, J Robert; Vijn, Peter; Boen, Patrick; Cross, Maurice

2010-06-29

Org 25435 is a new water-soluble alpha-amino acid ester intravenous anaesthetic which proved satisfactory in animal studies. This study aimed to assess the safety, tolerability and efficacy of Org 25435 and to obtain preliminary pharmacodynamic and pharmacokinetic data. In the Short Infusion study 8 healthy male volunteers received a 1 minute infusion of 0.25, 0.5, 1.0, or 2.0 mg/kg (n = 2 per group); a further 10 received 3.0 mg/kg (n = 5) or 4.0 mg/kg (n = 5). Following preliminary pharmacokinetic modelling 7 subjects received a titrated 30 minute Target Controlled Infusion (TCI), total dose 5.8-20 mg/kg. Within the Short Infusion study, all subjects were successfully anaesthetised at 3 and 4 mg/kg. Within the TCI study 5 subjects were anaesthetised and 2 showed signs of sedation. Org 25435 caused hypotension and tachycardia at doses over 2 mg/kg. Recovery from anaesthesia after a 30 min administration of Org 25435 was slow (13.7 min). Pharmacokinetic modelling suggests that the context sensitive half-time of Org 25435 is slightly shorter than that of propofol in infusions up to 20 minutes but progressively longer thereafter. Org 25435 is an effective intravenous anaesthetic in man at doses of 3 and 4 mg/kg given over 1 minute. Longer infusions can maintain anaesthesia but recovery is slow. Hypotension and tachycardia during anaesthesia and slow recovery of consciousness after cessation of drug administration suggest this compound has no advantages over currently available intravenous anaesthetics.

Reefgenomics.Org - a repository for marine genomics data.

PubMed

Liew, Yi Jin; Aranda, Manuel; Voolstra, Christian R

2016-01-01

Over the last decade, technological advancements have substantially decreased the cost and time of obtaining large amounts of sequencing data. Paired with the exponentially increased computing power, individual labs are now able to sequence genomes or transcriptomes to investigate biological questions of interest. This has led to a significant increase in available sequence data. Although the bulk of data published in articles are stored in public sequence databases, very often, only raw sequencing data are available; miscellaneous data such as assembled transcriptomes, genome annotations etc. are not easily obtainable through the same means. Here, we introduce our website (http://reefgenomics.org) that aims to centralize genomic and transcriptomic data from marine organisms. Besides providing convenient means to download sequences, we provide (where applicable) a genome browser to explore available genomic features, and a BLAST interface to search through the hosted sequences. Through the interface, multiple datasets can be queried simultaneously, allowing for the retrieval of matching sequences from organisms of interest. The minimalistic, no-frills interface reduces visual clutter, making it convenient for end-users to search and explore processed sequence data. DATABASE URL: http://reefgenomics.org. © The Author(s) 2016. Published by Oxford University Press.

Hippocampome.org: a knowledge base of neuron types in the rodent hippocampus

PubMed Central

Wheeler, Diek W; White, Charise M; Rees, Christopher L; Komendantov, Alexander O; Hamilton, David J; Ascoli, Giorgio A

2015-01-01

Hippocampome.org is a comprehensive knowledge base of neuron types in the rodent hippocampal formation (dentate gyrus, CA3, CA2, CA1, subiculum, and entorhinal cortex). Although the hippocampal literature is remarkably information-rich, neuron properties are often reported with incompletely defined and notoriously inconsistent terminology, creating a formidable challenge for data integration. Our extensive literature mining and data reconciliation identified 122 neuron types based on neurotransmitter, axonal and dendritic patterns, synaptic specificity, electrophysiology, and molecular biomarkers. All ∼3700 annotated properties are individually supported by specific evidence (∼14,000 pieces) in peer-reviewed publications. Systematic analysis of this unprecedented amount of machine-readable information reveals novel correlations among neuron types and properties, the potential connectivity of the full hippocampal circuitry, and outstanding knowledge gaps. User-friendly browsing and online querying of Hippocampome.org may aid design and interpretation of both experiments and simulations. This powerful, simple, and extensible neuron classification endeavor is unique in its detail, utility, and completeness. DOI: http://dx.doi.org/10.7554/eLife.09960.001 PMID:26402459

Org-1, the Drosophila ortholog of Tbx1, is a direct activator of known identity genes during muscle specification

PubMed Central

Schaub, Christoph; Nagaso, Hideyuki; Jin, Hong; Frasch, Manfred

2012-01-01

Members of the T-Box gene family of transcription factors are important players in regulatory circuits that generate myogenic and cardiogenic lineage diversities in vertebrates. We show that during somatic myogenesis in Drosophila, the single ortholog of vertebrate Tbx1, optomotor-blind-related-gene-1 (org-1), is expressed in a small subset of muscle progenitors, founder cells and adult muscle precursors, where it overlaps with the products of the muscle identity genes ladybird (lb) and slouch (slou). In addition, org-1 is expressed in the lineage of the heart-associated alary muscles. org-1 null mutant embryos lack Lb and Slou expression within the muscle lineages that normally co-express org-1. As a consequence, the respective muscle fibers and adult muscle precursors are either severely malformed or missing, as are the alary muscles. To address the mechanisms that mediate these regulatory interactions between Org-1, Lb and Slou, we characterized distinct enhancers associated with somatic muscle expression of lb and slou. We demonstrate that these lineage- and stage-specific cis-regulatory modules (CRMs) bind Org-1 in vivo, respond to org-1 genetically and require T-box domain binding sites for their activation. In summary, we propose that org-1 is a common and direct upstream regulator of slou and lb in the developmental pathway of these two neighboring muscle lineages. Cross-repression between slou and lb and combinatorial activation of lineage-specific targets by Org-1–Slou and Org-1–Lb, respectively, then leads to the distinction between the two lineages. These findings provide new insights into the regulatory circuits that control the proper pattering of the larval somatic musculature in Drosophila. PMID:22318630

Org-1, the Drosophila ortholog of Tbx1, is a direct activator of known identity genes during muscle specification.

PubMed

Schaub, Christoph; Nagaso, Hideyuki; Jin, Hong; Frasch, Manfred

2012-03-01

Members of the T-Box gene family of transcription factors are important players in regulatory circuits that generate myogenic and cardiogenic lineage diversities in vertebrates. We show that during somatic myogenesis in Drosophila, the single ortholog of vertebrate Tbx1, optomotor-blind-related-gene-1 (org-1), is expressed in a small subset of muscle progenitors, founder cells and adult muscle precursors, where it overlaps with the products of the muscle identity genes ladybird (lb) and slouch (slou). In addition, org-1 is expressed in the lineage of the heart-associated alary muscles. org-1 null mutant embryos lack Lb and Slou expression within the muscle lineages that normally co-express org-1. As a consequence, the respective muscle fibers and adult muscle precursors are either severely malformed or missing, as are the alary muscles. To address the mechanisms that mediate these regulatory interactions between Org-1, Lb and Slou, we characterized distinct enhancers associated with somatic muscle expression of lb and slou. We demonstrate that these lineage- and stage-specific cis-regulatory modules (CRMs) bind Org-1 in vivo, respond to org-1 genetically and require T-box domain binding sites for their activation. In summary, we propose that org-1 is a common and direct upstream regulator of slou and lb in the developmental pathway of these two neighboring muscle lineages. Cross-repression between slou and lb and combinatorial activation of lineage-specific targets by Org-1-Slou and Org-1-Lb, respectively, then leads to the distinction between the two lineages. These findings provide new insights into the regulatory circuits that control the proper pattering of the larval somatic musculature in Drosophila.

The LENR-CANR.ORG Website, its Past and Future

NASA Astrophysics Data System (ADS)

Rothwell, J.; Storms, E.

2005-12-01

The LENR-CANR.org web site has proven to be a popular source of information about cold fusion. This site has distributed more full text papers about LENR than any other source. In addition, it contains many features that allow easy search and insertion of the discovered references into a document.

Paleomagnetism.org: An online multi-platform open source environment for paleomagnetic data analysis

NASA Astrophysics Data System (ADS)

Koymans, Mathijs R.; Langereis, Cor G.; Pastor-Galán, Daniel; van Hinsbergen, Douwe J. J.

2016-08-01

This contribution provides an overview of Paleomagnetism.org, an open-source, multi-platform online environment for paleomagnetic data analysis. Paleomagnetism.org provides an interactive environment where paleomagnetic data can be interpreted, evaluated, visualized, and exported. The Paleomagnetism.org application is split in to an interpretation portal, a statistics portal, and a portal for miscellaneous paleomagnetic tools. In the interpretation portal, principle component analysis can be performed on visualized demagnetization diagrams. Interpreted directions and great circles can be combined to find great circle solutions. These directions can be used in the statistics portal, or exported as data and figures. The tools in the statistics portal cover standard Fisher statistics for directions and VGPs, including other statistical parameters used as reliability criteria. Other available tools include an eigenvector approach foldtest, two reversal test including a Monte Carlo simulation on mean directions, and a coordinate bootstrap on the original data. An implementation is included for the detection and correction of inclination shallowing in sediments following TK03.GAD. Finally we provide a module to visualize VGPs and expected paleolatitudes, declinations, and inclinations relative to widely used global apparent polar wander path models in coordinates of major continent-bearing plates. The tools in the miscellaneous portal include a net tectonic rotation (NTR) analysis to restore a body to its paleo-vertical and a bootstrapped oroclinal test using linear regressive techniques, including a modified foldtest around a vertical axis. Paleomagnetism.org provides an integrated approach for researchers to work with visualized (e.g. hemisphere projections, Zijderveld diagrams) paleomagnetic data. The application constructs a custom exportable file that can be shared freely and included in public databases. This exported file contains all data and can later be

Effect of the glucocorticoid receptor antagonist Org 34850 on fast and delayed feedback of corticosterone release.

PubMed

Spiga, Francesca; Harrison, Louise R; Wood, Susan A; MacSweeney, Cliona P; Thomson, Fiona J; Craighead, Mark; Grassie, Morag; Lightman, Stafford L

2008-02-01

We investigated the effect of the glucocorticoid receptor (GR) antagonist Org 34850 on fast and delayed inhibition of corticosterone secretion in response to the synthetic glucocorticoid methylprednisolone (MPL). Male rats were implanted with a catheter in the right jugular vein, for blood sampling and MPL administration, and with an s.c. cannula for Org 34850 administration. All experiments were conducted at the diurnal hormonal peak in the late afternoon. Rats were connected to an automated sampling system and blood samples were collected every 5 or 10 min. Org 34850 (10 mg/kg, s.c.) or vehicle (5% mulgofen in saline) was injected at 1630 h; 30 min later, rats received an injection of MPL (500 microg/rat, i.v.) or saline (0.1 ml/rat). We found that an acute administration of MPL rapidly decreased the basal corticosterone secretion and this effect was not prevented by acute pretreatment with Org 34850. However, blockade of GR with Org 34850 prevented delayed inhibition of MPL on corticosterone secretion measured between 4 and 12 h after MPL administration. Our data suggest an involvement of GR in modulating delayed, but not fast, inhibition induced by MPL on basal corticosterone secretion.

[Neuromuscular blocking effects of Org 9426 (rocuronium bromide); a comparative study with vecuronium bromide in Japanese patients].

PubMed

Shingu, Koh; Masuzawa, Munehiro; Omote, Keiichi; Namiki, Akiyoshi; Kikuchi, Hirosato; Kawamada, Miwako; Sato, Shigehito; Kimura, Tomomasa; Hatano, Norio; Nakatsuka, Hideki; Morita, Kiyoshi; Hara, Tetsuya; Kanmura, Yuichi; Takeda, Junzo

2006-09-01

Efficacy and safety of Org 9426 were compared with those of vecuronium bromide in Japanese patients. We studied 88 Japanese patients undergoing surgery requiring general anesthesia. Patients were allocated randomly to receive intubation dose of 0.6 mg x kg(-1), 0.9 mg x kg(-1) of Org 9426 or 0.1mg x kg(-1) of vecuronium. Following an intubation dose, patients received maintenance doses of 0.1, 0.15 or 0.2 mg x kg(-1) of Org 9426 or 0.025 mg x kg(-1) of vecuronium. The neuromuscular block was monitored with acceleromyography using TOF stimuli. Sevoflurane was administered to all treatment groups after intubation. The onset times of the 0.6 and 0.9 mg x kg(-1) of Org 9426 groups were 84.6 and 77.1 sec respectively, which showed statistical difference between the onset time of 0.1 mg x kg(-1) of vecuronium, 125.7 sec. The intubation condition was similar among three treatment groups. The clinical durations of 0.6 and 0.9 mg x kg(-1) of Org 9426 and 0.1 mg x kg(-1) of vecuronium were 53.4, 73.4 and 59.9 min, respectively. Clinical duration and spontaneous recovery time of maintenance dose of 0.15 mg x kg(-1) of Org 9426 were similar to those of 0.025 mg x kg(-1) of vecuronium. Org 9426 showed more rapid onset time than that of vecuronium and similar clinical duration and recovery times to those of vecuronium in Japanese patients.

Enhancing Public Access to Relevant and Valued Medical Information: Fresh Directions for RadiologyInfo.org.

PubMed

Rubin, Geoffrey D; Krishnaraj, Arun; Mahesh, Mahadevappa; Rajendran, Ramji R; Fishman, Elliot K

2017-05-01

RadiologyInfo.org is a public information portal designed to support patient care and broaden public awareness of the essential role radiology plays in overall patient health care. Over the past 14 years, RadiologyInfo.org has evolved considerably to provide access to more than 220 mixed-media descriptions of tests, treatments, and diseases through a spectrum of mobile and desktop platforms, social media, and downloadable documents in both English and Spanish. In 2014, the RSNA-ACR Public Information Website Committee, which stewards RadiologyInfo.org, developed 3- to 5-year strategic and implementation plans for the website. The process was informed by RadiologyInfo.org user surveys, formal stakeholder interviews, focus groups, and usability testing. Metrics were established as key performance indicators to assess progress toward the stated goals of (1) optimizing content to enhance patient-centeredness, (2) enhancing reach and engagement, and (3) maintaining sustainability. Major changes resulting from this process include a complete redesign of the website, the replacement of text-rich PowerPoint presentations with conversational videos, and the development of an affiliate network. Over the past year, visits to RadiologyInfo.org have increased by 60.27% to 1,424,523 in August 2016 from 235 countries and territories. Twenty-two organizations have affiliated with RadiologyInfo.org with new organizations being added on a monthly basis. RadiologyInfo provides a tangible demonstration of how radiologists can engage directly with the global public to educate them on the value of radiology in their health care and to allay concerns and dispel misconceptions. Regular self-assessment and responsive planning will ensure its continued growth and relevance. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

BikeMaps.org: A Global Tool for Collision and Near Miss Mapping

PubMed Central

Nelson, Trisalyn A.; Denouden, Taylor; Jestico, Benjamin; Laberee, Karen; Winters, Meghan

2015-01-01

There are many public health benefits to cycling, such as chronic disease reduction and improved air quality. Real and perceived concerns about safety are primary barriers to new ridership. Due to limited forums for official reporting of cycling incidents, lack of comprehensive data is limiting our ability to study cycling safety and conduct surveillance. Our goal is to introduce BikeMaps.org, a new website developed by the authors for crowd-source mapping of cycling collisions and near misses. BikeMaps.org is a global mapping system that allows citizens to map locations of cycling incidents and report on the nature of the event. Attributes collected are designed for spatial modeling research on predictors of safety and risk, and to aid surveillance and planning. Released in October 2014, within 2 months the website had more than 14,000 visitors and mapping in 14 countries. Collisions represent 38% of reports (134/356) and near misses 62% (222/356). In our pilot city, Victoria, Canada, citizens mapped data equivalent to about 1 year of official cycling collision reports within 2 months via BikeMaps.org. Using report completeness as an indicator, early reports indicate that data are of high quality with 50% being fully attributed and another 10% having only one missing attribute. We are advancing this technology, with the development of a mobile App, improved data visualization, real-time altering of hazard reports, and automated open-source tools for data sharing. Researchers and citizens interested in utilizing the BikeMaps.org technology can get involved by encouraging citizen mapping in their region. PMID:25870852

BikeMaps.org: A Global Tool for Collision and Near Miss Mapping.

PubMed

Nelson, Trisalyn A; Denouden, Taylor; Jestico, Benjamin; Laberee, Karen; Winters, Meghan

2015-01-01

There are many public health benefits to cycling, such as chronic disease reduction and improved air quality. Real and perceived concerns about safety are primary barriers to new ridership. Due to limited forums for official reporting of cycling incidents, lack of comprehensive data is limiting our ability to study cycling safety and conduct surveillance. Our goal is to introduce BikeMaps.org, a new website developed by the authors for crowd-source mapping of cycling collisions and near misses. BikeMaps.org is a global mapping system that allows citizens to map locations of cycling incidents and report on the nature of the event. Attributes collected are designed for spatial modeling research on predictors of safety and risk, and to aid surveillance and planning. Released in October 2014, within 2 months the website had more than 14,000 visitors and mapping in 14 countries. Collisions represent 38% of reports (134/356) and near misses 62% (222/356). In our pilot city, Victoria, Canada, citizens mapped data equivalent to about 1 year of official cycling collision reports within 2 months via BikeMaps.org. Using report completeness as an indicator, early reports indicate that data are of high quality with 50% being fully attributed and another 10% having only one missing attribute. We are advancing this technology, with the development of a mobile App, improved data visualization, real-time altering of hazard reports, and automated open-source tools for data sharing. Researchers and citizens interested in utilizing the BikeMaps.org technology can get involved by encouraging citizen mapping in their region.

HemOnc.org: A Collaborative Online Knowledge Platform for Oncology Professionals

PubMed Central

Warner, Jeremy L.; Cowan, Andrew J.; Hall, Aric C.; Yang, Peter C.

2015-01-01

Purpose: Cancer care involves extensive knowledge about numerous chemotherapy drugs and chemotherapy regimens. This information is constantly evolving, and there has been no freely available, comprehensive, centralized repository of chemotherapy information to date. Methods: We created an online, freely accessible, ad-free, collaborative wiki of chemotherapy information entitled HemOnc.org to address the unmet need for a central repository of this information. This Web site was developed with wiki development software and is hosted on a cloud platform. Chemotherapy drug and regimen information (including regimen variants), as well as other information of interest to hematology/oncology professionals, is housed on the site in a fully referenced and standardized format. Accredited users are allowed to freely contribute information to the site. Results: From its inception in November 2011, HemOnc.org has grown rapidly and most recently has detailed information on 383 drugs and 1,298 distinct chemotherapy regimens (not counting variants) in 92 disease subtypes. There are regularly more than 2,000 visitors per week from the United States and international locations. A user evaluation demonstrated that users find the site useful, usable, and recommendable. Conclusion: HemOnc.org is now the largest free source of chemotherapy drug and regimen information and is widely used. Future enhancements, including more metadata about drugs and increasingly detailed efficacy and toxicity information, will continue to improve the value of the resource. PMID:25736385

An update on sORFs.org: a repository of small ORFs identified by ribosome profiling.

PubMed

Olexiouk, Volodimir; Van Criekinge, Wim; Menschaert, Gerben

2018-01-04

sORFs.org (http://www.sorfs.org) is a public repository of small open reading frames (sORFs) identified by ribosome profiling (RIBO-seq). This update elaborates on the major improvements implemented since its initial release. sORFs.org now additionally supports three more species (zebrafish, rat and Caenorhabditis elegans) and currently includes 78 RIBO-seq datasets, a vast increase compared to the three that were processed in the initial release. Therefore, a novel pipeline was constructed that also enables sORF detection in RIBO-seq datasets comprising solely elongating RIBO-seq data while previously, matching initiating RIBO-seq data was necessary to delineate the sORFs. Furthermore, a novel noise filtering algorithm was designed, able to distinguish sORFs with true ribosomal activity from simulated noise, consequently reducing the false positive identification rate. The inclusion of other species also led to the development of an inner BLAST pipeline, assessing sequence similarity between sORFs in the repository. Building on the proof of concept model in the initial release of sORFs.org, a full PRIDE-ReSpin pipeline was now released, reprocessing publicly available MS-based proteomics PRIDE datasets, reporting on true translation events. Next to reporting those identified peptides, sORFs.org allows visual inspection of the annotated spectra within the Lorikeet MS/MS viewer, thus enabling detailed manual inspection and interpretation. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

genenames.org: the HGNC resources in 2011

PubMed Central

Seal, Ruth L.; Gordon, Susan M.; Lush, Michael J.; Wright, Mathew W.; Bruford, Elspeth A.

2011-01-01

The HUGO Gene Nomenclature Committee (HGNC) aims to assign a unique gene symbol and name to every human gene. The HGNC database currently contains almost 30 000 approved gene symbols, over 19 000 of which represent protein-coding genes. The public website, www.genenames.org, displays all approved nomenclature within Symbol Reports that contain data curated by HGNC editors and links to related genomic, phenotypic and proteomic information. Here we describe improvements to our resources, including a new Quick Gene Search, a new List Search, an integrated HGNC BioMart and a new Statistics and Downloads facility. PMID:20929869

A randomised trial of the effect of the glycine reuptake inhibitor Org 25935 on cognitive performance in healthy male volunteers.

PubMed

Christmas, David; Diaper, Alison; Wilson, Sue; Rich, Ann; Phillips, Suzanne; Udo de Haes, Joanna; Sjogren, Magnus; Nutt, David

2014-03-01

Cognitive impairment is integral to many neurological illnesses. Specific enhancement of glutamatergic transmission may improve memory and learning. Org 25935 increases the synaptic availability of glycine, an obligate co-agonist with glutamate at N-methyl-D-aspartate receptors. We hypothesised that Org 25935 would acutely improve the learning and memory of healthy volunteers. A randomised, double-blind, parallel-group, single-dose study of Org 25935 and placebo was carried out. Thirty-two healthy male volunteers took either 12-mg Org 25935 or matching placebo and were later assessed with the manikin task, digit span and verbal memory tests. Systematic assessments of cardiovascular and adverse events were also taken. There was no effect of Org 25935 on reaction time, number of correct responses or learning (greater or slower improvement over successive tasks) compared with placebo. Org 25935 caused significantly more dizziness and drowsiness compared with placebo; these side effects were mainly mild. A single dose of Org 25935 does not improve learning or memory in healthy male individuals. However, the drug was well tolerated, and it remains to be seen whether it would have a positive effect on cognition in patient groups with pre-existing cognitive deficits.

Genenames.org: the HGNC and VGNC resources in 2017.

PubMed

Yates, Bethan; Braschi, Bryony; Gray, Kristian A; Seal, Ruth L; Tweedie, Susan; Bruford, Elspeth A

2017-01-04

The HUGO Gene Nomenclature Committee (HGNC) based at the European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. Currently the HGNC database contains almost 40 000 approved gene symbols, over 19 000 of which represent protein-coding genes. In addition to naming genomic loci we manually curate genes into family sets based on shared characteristics such as homology, function or phenotype. We have recently updated our gene family resources and introduced new improved visualizations which can be seen alongside our gene symbol reports on our primary website http://www.genenames.org In 2016 we expanded our remit and formed the Vertebrate Gene Nomenclature Committee (VGNC) which is responsible for assigning names to vertebrate species lacking a dedicated nomenclature group. Using the chimpanzee genome as a pilot project we have approved symbols and names for over 14 500 protein-coding genes in chimpanzee, and have developed a new website http://vertebrate.genenames.org to distribute these data. Here, we review our online data and resources, focusing particularly on the improvements and new developments made during the last two years. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

HemOnc.org: A Collaborative Online Knowledge Platform for Oncology Professionals.

PubMed

Warner, Jeremy L; Cowan, Andrew J; Hall, Aric C; Yang, Peter C

2015-05-01

Cancer care involves extensive knowledge about numerous chemotherapy drugs and chemotherapy regimens. This information is constantly evolving, and there has been no freely available, comprehensive, centralized repository of chemotherapy information to date. We created an online, freely accessible, ad-free, collaborative wiki of chemotherapy information entitled HemOnc.org to address the unmet need for a central repository of this information. This Web site was developed with wiki development software and is hosted on a cloud platform. Chemotherapy drug and regimen information (including regimen variants), as well as other information of interest to hematology/oncology professionals, is housed on the site in a fully referenced and standardized format. Accredited users are allowed to freely contribute information to the site. From its inception in November 2011, HemOnc.org has grown rapidly and most recently has detailed information on 383 drugs and 1,298 distinct chemotherapy regimens (not counting variants) in 92 disease subtypes. There are regularly more than 2,000 visitors per week from the United States and international locations. A user evaluation demonstrated that users find the site useful, usable, and recommendable. HemOnc.org is now the largest free source of chemotherapy drug and regimen information and is widely used. Future enhancements, including more metadata about drugs and increasingly detailed efficacy and toxicity information, will continue to improve the value of the resource. Copyright © 2015 by American Society of Clinical Oncology.

The phosphodiesterase 3 inhibitor ORG 9935 inhibits oocyte maturation in the naturally selected dominant follicle in rhesus macaques.

PubMed

Jensen, Jeffrey T; Zelinski, Mary B; Stanley, Jessica E; Fanton, John W; Stouffer, Richard L

2008-04-01

The study was conducted to determine whether the phosphodiesterase (PDE) 3 inhibitor ORG 9935 prevents the resumption of meiosis in primate oocytes during natural menstrual cycles. Regularly cycling adult female macaques (n=8) were followed during the follicular phase and then started on a 2-day treatment regimen of human recombinant gonadotropins to control the timing of ovulation. Monkeys received no further treatment (controls) or ORG 9935. Oocytes were recovered by laparoscopic follicle aspiration 27 h after an ovulatory stimulus, cultured in vitro in the absence of inhibitor and inseminated. The primary outcome was the meiotic stage of the oocyte. In six ORG 9935 cycles, five of the recovered oocytes were germinal vesicle (GV)-intact, and one exhibited GV breakdown (GVBD). In contrast, all three oocytes that recovered during control cycles were GVBD (p<.05). None of the ORG 9935-treated oocytes underwent fertilization compared with 2/3 (67%) from controls. These results demonstrate that ORG 9935 blocks resumption of meiosis in the naturally selected dominant follicle in primates and suggest that PDE3 inhibitors have potential clinical use as contraceptives in women.

The Seamount Catalog in EarthRef.org

NASA Astrophysics Data System (ADS)

Gotberg, N. K.; Koppers, A. A.; Staudigel, H.; Perez, J.

2004-12-01

Seamounts are important to research and education in many scientific fields, providing a wide range of data on physical, chemical, biological and geological processes. In order to make a diverse set of seamount data accessible we have developed the Seamount Catalog in EarthRef.org, available through the http://earthref.org/databases/SC/. The primary goal of the Seamount Catalog is to provide access to digital data files on a large assortment of interdisciplinary seamount research. The catalog can be searched at a variety of ability or expert levels allowing it to be used from basic education to advanced research. Each seamount is described in terms of its location, height, volume, elongation, azimuth, irregularity, rifts, morphological classification and relation to other features. GEBCO (General Bathymetric Chart of the Ocean) gazetteer data (2002; 2003) is included in the database in order to provide information on the history, discovery and names of the seamounts. Screen-optimized bathymetry maps, grid files and the original multibeam data files are available for online viewing with higher resolution downloadable versions (AI, PS, PDF) also offered. The data files for each seamount include a map made from the multibeam data only, a map made from Smith and Sandwell's (1996) predicted bathymetry, a merged map incorporating both data sets, and a map showing the differences between the two data sets. We are working towards expanding the Seamount Catalog by integrating bathymetry data from various sources, developing and linking disciplinary reference models, and integrating information from multiple disciplines and from the literature. We hope to create a data integrative environment that provides access to seamount data and the tools needed for working with that data.

Induction of ovulation by a potent, orally active, low molecular weight agonist (Org 43553) of the luteinizing hormone receptor.

PubMed

van de Lagemaat, R; Timmers, C M; Kelder, J; van Koppen, C; Mosselman, S; Hanssen, R G J M

2009-03-01

In assisted reproductive technology, human chorionic gonadotrophin (hCG) is administered subcutaneously for the induction of oocyte maturation and ovulation. Our efforts to develop orally bioavailable luteinizing hormone (LH) receptor agonists have led to the discovery of Org 43553, a low molecular weight (LMW) LH receptor (LH-R) agonist. Org 43553 was tested in vitro and in vivo in pre-clinical pharmacological models to demonstrate efficacy and oral availability. Org 43553 is a potent stimulator of the human LH-R in vitro (EC(50) 3.7 nM). In primary mouse Leydig cells, Org 43553 stimulated testosterone production. Pharmacokinetic analyses showed high oral bioavailability in rats (79%) and dogs (44%) with a shorter half-life compared with hCG (3.4 versus 5.6 h in the rat). Ovulation induction by Org 43553 was demonstrated in immature mice as well as in cyclic rats after single-dose oral administration (50 mg/kg). The ovulated oocytes were of good quality as demonstrated by successful fertilization and implantation of normal embryos. In male rats, testosterone production was substantially induced after oral administration. Org 43553 is the first LMW LH-R mimetic with demonstrated in vivo efficacy upon oral administration and could therefore replace subcutaneously administered hCG. The elimination half-life of Org 43553 is substantially shorter than hCG, which could potentially represent a clinical benefit in reducing the risk of ovarian hyperstimulation syndrome (OHSS).

Teaching NMR spectra analysis with nmr.cheminfo.org.

PubMed

Patiny, Luc; Bolaños, Alejandro; Castillo, Andrés M; Bernal, Andrés; Wist, Julien

2018-06-01

Teaching spectra analysis and structure elucidation requires students to get trained on real problems. This involves solving exercises of increasing complexity and when necessary using computational tools. Although desktop software packages exist for this purpose, nmr.cheminfo.org platform offers students an online alternative. It provides a set of exercises and tools to help solving them. Only a small number of exercises are currently available, but contributors are invited to submit new ones and suggest new types of problems. Copyright © 2018 John Wiley & Sons, Ltd.

Extracting and connecting chemical structures from text sources using chemicalize.org.

PubMed

Southan, Christopher; Stracz, Andras

2013-04-23

Exploring bioactive chemistry requires navigating between structures and data from a variety of text-based sources. While PubChem currently includes approximately 16 million document-extracted structures (15 million from patents) the extent of public inter-document and document-to-database links is still well below any estimated total, especially for journal articles. A major expansion in access to text-entombed chemistry is enabled by chemicalize.org. This on-line resource can process IUPAC names, SMILES, InChI strings, CAS numbers and drug names from pasted text, PDFs or URLs to generate structures, calculate properties and launch searches. Here, we explore its utility for answering questions related to chemical structures in documents and where these overlap with database records. These aspects are illustrated using a common theme of Dipeptidyl Peptidase 4 (DPPIV) inhibitors. Full-text open URL sources facilitated the download of over 1400 structures from a DPPIV patent and the alignment of specific examples with IC50 data. Uploading the SMILES to PubChem revealed extensive linking to patents and papers, including prior submissions from chemicalize.org as submitting source. A DPPIV medicinal chemistry paper was completely extracted and structures were aligned to the activity results table, as well as linked to other documents via PubChem. In both cases, key structures with data were partitioned from common chemistry by dividing them into individual new PDFs for conversion. Over 500 structures were also extracted from a batch of PubMed abstracts related to DPPIV inhibition. The drug structures could be stepped through each text occurrence and included some converted MeSH-only IUPAC names not linked in PubChem. Performing set intersections proved effective for detecting compounds-in-common between documents and merged extractions. This work demonstrates the utility of chemicalize.org for the exploration of chemical structure connectivity between documents and

The Plant Genome Integrative Explorer Resource: PlantGenIE.org.

PubMed

Sundell, David; Mannapperuma, Chanaka; Netotea, Sergiu; Delhomme, Nicolas; Lin, Yao-Cheng; Sjödin, Andreas; Van de Peer, Yves; Jansson, Stefan; Hvidsten, Torgeir R; Street, Nathaniel R

2015-12-01

Accessing and exploring large-scale genomics data sets remains a significant challenge to researchers without specialist bioinformatics training. We present the integrated PlantGenIE.org platform for exploration of Populus, conifer and Arabidopsis genomics data, which includes expression networks and associated visualization tools. Standard features of a model organism database are provided, including genome browsers, gene list annotation, Blast homology searches and gene information pages. Community annotation updating is supported via integration of WebApollo. We have produced an RNA-sequencing (RNA-Seq) expression atlas for Populus tremula and have integrated these data within the expression tools. An updated version of the ComPlEx resource for performing comparative plant expression analyses of gene coexpression network conservation between species has also been integrated. The PlantGenIE.org platform provides intuitive access to large-scale and genome-wide genomics data from model forest tree species, facilitating both community contributions to annotation improvement and tools supporting use of the included data resources to inform biological insight. © 2015 The Authors. New Phytologist © 2015 New Phytologist Trust.

Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus.

PubMed

Su, Xiaowei W; Li, Xiao-Yuan; Banasr, Mounira; Koo, Ja Wook; Shahid, Mohammed; Henry, Brian; Duman, Ronald S

2009-10-01

Currently available antidepressants upregulate hippocampal neurogenesis and prefrontal gliogenesis after chronic administration, which could block or reverse the effects of stress. Allosteric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor potentiators (ARPs), which have novel targets compared to current antidepressants, have been shown to have antidepressant properties in neurogenic and behavioral models. This study analyzed the effect of the ARP Org 26576 on the proliferation, survival, and differentiation of neurons and glia in the hippocampus and prelimbic cortex of adult rats. Male Sprague-Dawley rats received acute (single day) or chronic (21 day) twice-daily intraperitoneal injections of Org 26576 (1-10 mg/kg). Bromodeoxyuridine (BrdU) immunohistochemistry was conducted 24 h or 28 days after the last drug injection for the analysis of cell proliferation or survival, respectively. Confocal immunofluorescence analysis was used to determine the phenotype of surviving cells. Acute administration of Org 26576 did not increase neuronal cell proliferation. However, chronic administration of Org 26576 increased progenitor cell proliferation in dentate gyrus (approximately 40%) and in prelimbic cortex (approximately 35%) at the 10-mg/kg dosage. Cells born in response to chronic Org 26576 in dentate gyrus exhibited increased rates of survival (approximately 30%) with the majority of surviving cells expressing a neuronal phenotype. Findings suggest that Org 26576 may have antidepressant properties, which may be attributed, in part, to upregulation of hippocampal neurogenesis and prelimbic cell proliferation.

Ms2lda.org: web-based topic modelling for substructure discovery in mass spectrometry.

PubMed

Wandy, Joe; Zhu, Yunfeng; van der Hooft, Justin J J; Daly, Rónán; Barrett, Michael P; Rogers, Simon

2017-09-14

We recently published MS2LDA, a method for the decomposition of sets of molecular fragment data derived from large metabolomics experiments. To make the method more widely available to the community, here we present ms2lda.org, a web application that allows users to upload their data, run MS2LDA analyses and explore the results through interactive visualisations. Ms2lda.org takes tandem mass spectrometry data in many standard formats and allows the user to infer the sets of fragment and neutral loss features that co-occur together (Mass2Motifs). As an alternative workflow, the user can also decompose a dataset onto predefined Mass2Motifs. This is accomplished through the web interface or programmatically from our web service. The website can be found at http://ms2lda.org , while the source code is available at https://github.com/sdrogers/ms2ldaviz under the MIT license. Supplementary data are available at Bioinformatics online. © The Author(s) 2017. Published by Oxford University Press.

Org-1 is required for the diversification of circular visceral muscle founder cells and normal midgut morphogenesis

PubMed Central

Schaub, Christoph; Frasch, Manfred

2013-01-01

The T-Box family of transcription factors plays fundamental roles in the generation of appropriate spatial and temporal gene expression profiles during cellular differentiation and organogenesis in animals. In this study we report that the Drosophila Tbx1 orthologue optomotor-blind-related-gene-1 (org-1) exerts a pivotal function in the diversification of circular visceral muscle founder cell identities in Drosophila. In embryos mutant for org-1, the specification of the midgut musculature per se is not affected, but the differentiating midgut fails to form the anterior and central midgut constrictions and lacks the gastric caeca. We demonstrate that this phenotype results from the nearly complete loss of the founder cell specific expression domains of several genes known to regulate midgut morphogenesis, including odd-paired (opa), teashirt (tsh), Ultrabithorax (Ubx), decapentaplegic (dpp) and wingless (wg). To address the mechanisms that mediate the regulatory inputs from org-1 towards Ubx, dpp, and wg in these founder cells we genetically dissected known visceral mesoderm specific cis-regulatory-modules (CRMs) of these genes. The analyses revealed that the activities of the dpp and wg CRMs depend on org-1, the CRMs are bound by Org-1 in vivo and their T-Box binding sites are essential for their activation in the visceral muscle founder cells. We conclude that Org-1 acts within a well-defined signaling and transcriptional network of the trunk visceral mesoderm as a crucial founder cell-specific competence factor, in concert with the general visceral mesodermal factor Biniou. As such, it directly regulates several key genes involved in the establishment of morphogenetic centers along the anteroposterior axis of the visceral mesoderm, which subsequently organize the formation of midgut constrictions and gastric caeca and thereby determine the morphology of the midgut. PMID:23380635

Org-1 is required for the diversification of circular visceral muscle founder cells and normal midgut morphogenesis.

PubMed

Schaub, Christoph; Frasch, Manfred

2013-04-15

The T-Box family of transcription factors plays fundamental roles in the generation of appropriate spatial and temporal gene expression profiles during cellular differentiation and organogenesis in animals. In this study we report that the Drosophila Tbx1 orthologue optomotor-blind-related-gene-1 (org-1) exerts a pivotal function in the diversification of circular visceral muscle founder cell identities in Drosophila. In embryos mutant for org-1, the specification of the midgut musculature per se is not affected, but the differentiating midgut fails to form the anterior and central midgut constrictions and lacks the gastric caeca. We demonstrate that this phenotype results from the nearly complete loss of the founder cell specific expression domains of several genes known to regulate midgut morphogenesis, including odd-paired (opa), teashirt (tsh), Ultrabithorax (Ubx), decapentaplegic (dpp) and wingless (wg). To address the mechanisms that mediate the regulatory inputs from org-1 towards Ubx, dpp, and wg in these founder cells we genetically dissected known visceral mesoderm specific cis-regulatory-modules (CRMs) of these genes. The analyses revealed that the activities of the dpp and wg CRMs depend on org-1, the CRMs are bound by Org-1 in vivo and their T-Box binding sites are essential for their activation in the visceral muscle founder cells. We conclude that Org-1 acts within a well-defined signaling and transcriptional network of the trunk visceral mesoderm as a crucial founder cell-specific competence factor, in concert with the general visceral mesodermal factor Biniou. As such, it directly regulates several key genes involved in the establishment of morphogenetic centers along the anteroposterior axis of the visceral mesoderm, which subsequently organize the formation of midgut constrictions and gastric caeca and thereby determine the morphology of the midgut. Copyright © 2013 Elsevier Inc. All rights reserved.

Assessment of seizure liability of Org 306039, a 5-HT2c agonist, using hippocampal brain slice and rodent EEG telemetry.

PubMed

Markgraf, Carrie G; DeBoer, Erik; Zhai, Jin; Cornelius, Lara; Zhou, Ying Ying; MacSweeney, Cliona

2014-01-01

Evaluation of the seizure potential for a CNS-targeted pharmaceutical compound before it is administered to humans is an important part of development. The current in vitro and in vivo studies were undertaken to characterize the seizure potential of the potent and selective 5-HT2c agonist Org 306039. Rat hippocampal slices (n=5) were prepared and Org 306039 was applied over a concentration range of 0-1000μM. Male Sprague-Dawley rats, implanted with telemetry EEG recording electrodes received either vehicle (n=4) or 100mg/kg Org 306039 (n=4) by oral gavage daily for 10days. EEG was recorded continuously for 22±1h post-dose each day. Post-dose behavior observations were conducted daily for 2h. Body temperature was measured at 1 and 2h post-dose. On Day 7, blood samples were drawn for pharmacokinetic analysis of Org 306039. In hippocampal slice, Org 306039 elicited a concentration-dependent increase in population spike area and number recorded from CA1 area, indicating seizure-genic potential. In telemetered rats, Org 306039 was associated with a decrease in body weight, a decrease in body temperature and the appearance of seizure-related behaviors and pre-seizure waveforms on EEG. One rat exhibited an overt seizure. Plasma concentrations of Org 306039 were similar among the 4 rats in the Org-treated group. Small group size made it difficult to determine a PK-PD relationship. These results indicate that the in vitro and in vivo models complement each other in the characterization of the seizure potential of CNS-targeted compounds such as the 5-HT2c agonist Org 306039. Copyright © 2014 Elsevier Inc. All rights reserved.

PTC MathCAD and Workgroup Manager: Implementation in a Multi-Org System

NASA Technical Reports Server (NTRS)

Jones, Corey

2015-01-01

In this presentation, the presenter will review what was done at Kennedy Space Center to deploy and implement PTC MathCAD and PTC Workgroup Manager in a multi-org system. During the presentation the presenter will explain how they configured PTC Windchill to create custom soft-types and object initialization rules for their custom numbering scheme and why they choose these methods. This presentation will also include how to modify the EPM default soft-type file in the PTC Windchill server codebase folder. The presenter will also go over the code used in a start up script to initiate PTC MathCAD and PTC Workgroup Manager in the proper order, and also set up the environment variables when running both PTC Workgroup Manager and PTC Creo. The configuration.ini file the presenter used will also be reviewed to show you how to set up the PTC Workgroup Manager and customized it to their user community. This presentation will be of interest to administrators trying to create a similar set-up in either a single org or multiple org system deployment. The big take away will be ideas and best practices learned through implementing this system, and the lessons learned what to do and not to do when setting up this configuration. Attendees will be exposed to several different sets of code used and that worked well and will hear some limitations on what the software can accomplish when configured this way.

The selective estrogen receptor alpha agonist Org 37663 induces estrogenic effects but lacks antirheumatic activity: a phase IIa trial investigating efficacy and safety of Org 37663 in postmenopausal female rheumatoid arthritis patients receiving stable background methotrexate or sulfasalazine.

PubMed

van Vollenhoven, Ronald F; Houbiers, Jos G A; Buttgereit, Frank; In 't Hout, Joanna; Boers, Maarten; Leij, Susanne; Kvien, Tore K; Dijkmans, Ben A C; Szczepański, Leszek; Szombati, Istvan; Sierakowski, Stanislaw; Miltenburg, André M M

2010-02-01

Multiple lines of evidence suggest that sex hormones may play a role in the pathogenesis or clinical expression of rheumatoid arthritis (RA). Studies on the effects of exogenous estrogens in RA patients have yielded contradictory results. We undertook this study to determine the effects of the selective estrogen receptor alpha (ERalpha) agonist Org 37663 in patients with RA, in terms of both its estrogenic effects and its ability to ameliorate disease activity. A 10-week, multicenter, randomized, double-blind, placebo-controlled, parallel group, dose-finding, proof-of-concept trial was initiated to obtain data on the efficacy and safety of Org 37663 in postmenopausal female patients with RA who were receiving background treatment with either methotrexate or sulfasalazine. Patients were randomized to receive placebo or Org 37663 at doses of 4 mg/day, 15 mg/day, or 50 mg/week. The primary efficacy variable was the Disease Activity Score in 28 joints (DAS28). Org 37663 induced a clear biologic, estrogenic response in several organ systems, including a dose-related increase in levels of sex hormone binding globulin. However, the DAS28 decreased similarly for all treatment groups including placebo, indicating lack of clinical efficacy of Org 37663 in this trial. The observed lack of clinical benefit in RA patients treated with an ERalpha agonist, in association with a clear biologic response to the study drug, provides evidence that a biologically relevant ERalpha-mediated estrogenic effect is not associated with a clinically relevant effect on RA symptoms and signs.

Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index.

PubMed

van Lierop, Marie-José C; Alkema, Wynand; Laskewitz, Anke J; Dijkema, Rein; van der Maaden, Hans M; Smit, Martin J; Plate, Ralf; Conti, Paolo G M; Jans, Christan G J M; Timmers, C Marco; van Boeckel, Constant A A; Lusher, Scott J; McGuire, Ross; van Schaik, Rene C; de Vlieg, Jacob; Smeets, Ruben L; Hofstra, Claudia L; Boots, Annemieke M H; van Duin, Marcel; Ingelse, Benno A; Schoonen, Willem G E J; Grefhorst, Aldo; van Dijk, Theo H; Kuipers, Folkert; Dokter, Wim H A

2012-01-01

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal Glucocorticoid Receptor (GR)-selective compound (Org 214007-0) with a binding affinity to GR similar to that of prednisolone. Structural modelling of the GR-Org 214007-0 binding site shows disturbance of the loop between helix 11 and helix 12 of GR, confirmed by partial recruitment of the TIF2-3 peptide. Using various cell lines and primary human cells, we show here that Org 214007-0 acts as a partial GC agonist, since it repressed inflammatory genes and was less effective in induction of metabolic genes. More importantly, in vivo studies in mice indicated that Org 214007-0 retained full efficacy in acute inflammation models as well as in a chronic collagen-induced arthritis (CIA) model. Gene expression profiling of muscle tissue derived from arthritic mice showed a partial activity of Org 214007-0 at an equi-efficacious dosage of prednisolone, with an increased ratio in repression versus induction of genes. Finally, in mice Org 214007-0 did not induce elevated fasting glucose nor the shift in glucose/glycogen balance in the liver seen with an equi-efficacious dose of prednisolone. All together, our data demonstrate that Org 214007-0 is a novel SGRMs with an improved therapeutic index compared to prednisolone. This class of SGRMs can contribute to effective anti-inflammatory therapy with a lower risk for metabolic side effects.

Comparative Analysis of Opioid Queries on Erowid.org: An Opportunity to Advance Harm Reduction.

PubMed

Wightman, Rachel S; Perrone, Jeanmarie; Erowid, Fire; Erowid, Earth; Meisel, Zachary F; Nelson, Lewis S

2017-08-24

Many individuals who use opioids turn to online resources to gather information on effects, availability, and safety. Describe opioid index page views on Erowid.org to assess trends in public interest in particular opioids. Retrospective analysis of Erowid.org site traffic was performed to identify unique average daily visits to opioid pages. All data was normalized to that of visits to the heroin index page. Average daily visits to the index pages of each of 6 commonly abused opioids were assessed during the period of 2009 to 2015. Similarly, visits to 15 distinct opioid index pages at 5 time points (July, October 2014 and Jan, April, and July 2015) were described. From 2009 to 2015 a decrease in the number of page visits versus heroin (1.00) occurred for hydrocodone (0.87 to 0.59, -32%), oxycodone (1.38 to 0.99, -28%), and morphine (0.26 to 0.25, -6%). Increases in page visits compared to heroin occurred for fentanyl (0.18 to 0.47, +157%), tramadol (0.43 to 0.88, +106%), hydromorphone (0.19 to 0.24, +29%), and oxymorphone (0.11 to 0.13, +18%). Indexed to heroin (1.00) average opioid page visit frequencies from July 2014 to July 2015 were highest for oxycodone (1.02) and tramadol (0.81). Conclusion/Importance: Oxycodone and tramadol represent the greatest number of Erowid.org opioid page visits compared to heroin. The largest increase in visits over the study periods was for fentanyl and tramadol. The relationship of page visits on Erowid.org creates a unique opportunity for real-time evaluation of emerging drug trends and epidemiological study.

BioImg.org: A Catalog of Virtual Machine Images for the Life Sciences

PubMed Central

Dahlö, Martin; Haziza, Frédéric; Kallio, Aleksi; Korpelainen, Eija; Bongcam-Rudloff, Erik; Spjuth, Ola

2015-01-01

Virtualization is becoming increasingly important in bioscience, enabling assembly and provisioning of complete computer setups, including operating system, data, software, and services packaged as virtual machine images (VMIs). We present an open catalog of VMIs for the life sciences, where scientists can share information about images and optionally upload them to a server equipped with a large file system and fast Internet connection. Other scientists can then search for and download images that can be run on the local computer or in a cloud computing environment, providing easy access to bioinformatics environments. We also describe applications where VMIs aid life science research, including distributing tools and data, supporting reproducible analysis, and facilitating education. BioImg.org is freely available at: https://bioimg.org. PMID:26401099

BioImg.org: A Catalog of Virtual Machine Images for the Life Sciences.

PubMed

Dahlö, Martin; Haziza, Frédéric; Kallio, Aleksi; Korpelainen, Eija; Bongcam-Rudloff, Erik; Spjuth, Ola

2015-01-01

Virtualization is becoming increasingly important in bioscience, enabling assembly and provisioning of complete computer setups, including operating system, data, software, and services packaged as virtual machine images (VMIs). We present an open catalog of VMIs for the life sciences, where scientists can share information about images and optionally upload them to a server equipped with a large file system and fast Internet connection. Other scientists can then search for and download images that can be run on the local computer or in a cloud computing environment, providing easy access to bioinformatics environments. We also describe applications where VMIs aid life science research, including distributing tools and data, supporting reproducible analysis, and facilitating education. BioImg.org is freely available at: https://bioimg.org.

Over ten thousand cases and counting: acidbase.org is serving the critical care community.

PubMed

Elbers, Paul W G; Van Regenmortel, Niels; Gatz, Rainer

2015-01-01

Acidbase.org has been serving the critical care community for over a decade. The backbone of this online resource consists of Peter Stewart's original text "How to understand Acid-Base" which is freely available to everyone. In addition, Stewart's Textbook of Acid Base, which puts the theory in today's clinical context is available for purchase from the website. However, many intensivists use acidbase.org on a daily basis for its educational content and in particular for its analysis module. This review provides an overview of the history of the website, a tutorial and descriptive statistics of over 10,000 queries submitted to the analysis module.

Org 214007-0: A Novel Non-Steroidal Selective Glucocorticoid Receptor Modulator with Full Anti-Inflammatory Properties and Improved Therapeutic Index

PubMed Central

Laskewitz, Anke J.; Dijkema, Rein; van der Maaden, Hans M.; Smit, Martin J.; Plate, Ralf; Conti, Paolo G. M.; Jans, Christan G. J. M.; Timmers, C. Marco; van Boeckel, Constant A. A.; Lusher, Scott J.; McGuire, Ross; van Schaik, Rene C.; de Vlieg, Jacob; Smeets, Ruben L.; Hofstra, Claudia L.; Boots, Annemieke M. H.; van Duin, Marcel; Ingelse, Benno A.; Schoonen, Willem G. E. J.; Grefhorst, Aldo; van Dijk, Theo H.; Kuipers, Folkert; Dokter, Wim H. A.

2012-01-01

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal Glucocorticoid Receptor (GR)-selective compound (Org 214007-0) with a binding affinity to GR similar to that of prednisolone. Structural modelling of the GR-Org 214007-0 binding site shows disturbance of the loop between helix 11 and helix 12 of GR, confirmed by partial recruitment of the TIF2-3 peptide. Using various cell lines and primary human cells, we show here that Org 214007-0 acts as a partial GC agonist, since it repressed inflammatory genes and was less effective in induction of metabolic genes. More importantly, in vivo studies in mice indicated that Org 214007-0 retained full efficacy in acute inflammation models as well as in a chronic collagen-induced arthritis (CIA) model. Gene expression profiling of muscle tissue derived from arthritic mice showed a partial activity of Org 214007-0 at an equi-efficacious dosage of prednisolone, with an increased ratio in repression versus induction of genes. Finally, in mice Org 214007-0 did not induce elevated fasting glucose nor the shift in glucose/glycogen balance in the liver seen with an equi-efficacious dose of prednisolone. All together, our data demonstrate that Org 214007-0 is a novel SGRMs with an improved therapeutic index compared to prednisolone. This class of SGRMs can contribute to effective anti-inflammatory therapy with a lower risk for metabolic side effects. PMID:23152771

Effects of the ACTH(4-9) analogue, ORG 2766, on vincristine cytotoxicity in two human lymphoma cell lines, U937 and U715.

PubMed Central

Kiburg, B.; van de Loosdrecht, A. A.; Schweitzer, K. M.; Ossenkoppele, G. J.; Müller, L. J.; Heimans, J. J.; Huijgens, P. C.

1994-01-01

The use of cytotoxic drug vincristine (VCR) is limited by the occurrence of peripheral neuropathy. A neurotrophic ACTH(4-9) analogue, ORG 2766, is being studied for its protective effect. Possible modulatory effects of ORG 2766 on tumour cell growth and interference with the cytotoxic efficacy of VCR were studied in two human lymphoma cell lines, U937 and U715. The effects of ORG 2766 on cell growth and survival and on VCR-mediated cytotoxicity were investigated using two MTT-based assays to study direct cytotoxic effects and to assess residual growth after pretreatment. Treatment with ORG 2766 alone had no effect on cell growth and survival. Neither did this drug affect VCR cytotoxicity. However, after 96 h pretreatment with ORG 2766 and a culture period of 7 days, a reduction in residual growth and a potentiation of VCR-induced inhibition of growth capacity was observed in U715 cells, and to some extent also in U937 cells. It is concluded that ORG 2766 has no stimulatory effects on tumour growth and does not negatively interfere with VCR-mediated cytotoxicity. Rather it enhances the cytostatic effect of VCR. It is suggested that ORG 2766 can safely be used in clinical trials investigating the ability of ORG 2766 to counteract VCR-induced neurotoxicity. PMID:8123480

Effect of SanOrg123781A, a synthetic hexadecasaccharide, on clot-bound thrombin and factor Xa in vitro and in vivo.

PubMed

Hérault, J-P; Cappelle, M; Bernat, A; Millet, L; Bono, F; Schaeffer, P; Herbert, J-M

2003-09-01

Factor (F)Xa and thrombin bound to the clot during its formation contribute to the propensity of thrombi to activate the coagulation system. The aim of this work was to study the inhibition of clot-bound FXa and clot-bound thrombin by SanOrg123781A, a synthetic hexadecasaccharide that enhances the inhibition of thrombin and FXa by antithrombin (AT). SanOrg123781A, designed to exhibit low non-specific binding to proteins other than AT, was compared with heparin. In buffer, heparin and SanOrg123781A inhibited FXa and thrombin at similar concentrations [concentration inhibiting 50% (IC50) of Xa and IIa activity were, respectively: heparin 120 +/- 7 and 3 +/- 1 ng mL-1; SanOrg123781A 77 +/- 5 and 4 +/- 1 ng mL-1]. In human plasma, the activity of both compounds was reduced, although the activity of heparin was much more affected than that of SanOrg123781A (IC50 values for inhibition of FXa and FIIa activity were, respectively: heparin 100 +/- 5 and 800 +/- 40 ng mL-1; SanOrg123781A 10 +/- 5 and 30 +/- 3 ng mL-1). We demonstrated, in agreement with our previous results, that the procoagulant activity of the clot is essentially due to clot-bound FXa and to some extent to clot-bound thrombin. We showed that heparin and SanOrg123781A were able to inhibit fragment F1+2 generation induced by clot-bound FXa with IC50 values of 2 +/- 0.5 micro g mL-1 and 0.6 +/- 0.2 micro g mL-1, respectively. Both compounds also inhibited clot-bound thrombin activity, the IC50 values of heparin and SanOrg123781A being 1 +/- 0.01 micro g mL-1 and 0.1 +/- 0.1 micro g mL-1, respectively. Moreover, both heparin and SanOrg123781A significantly inhibited fibrinopeptide A generated by the action of clot-bound thrombin on fibrinogen but also by free thrombin generated from prothrombin by clot-bound FXa with IC50 values of 4 +/- 0.6 and 1 +/- 0.1 micro g mL-1, respectively. As with clot-bound enzymatic activities, SanOrg123781A was three times more active than heparin in vivo on fibrinogen accretion

NeuroMorpho.Org implementation of digital neuroscience: dense coverage and integration with the NIF

PubMed Central

Halavi, Maryam; Polavaram, Sridevi; Donohue, Duncan E.; Hamilton, Gail; Hoyt, Jeffrey; Smith, Kenneth P.; Ascoli, Giorgio A.

2009-01-01

Neuronal morphology affects network connectivity, plasticity, and information processing. Uncovering the design principles and functional consequences of dendritic and axonal shape necessitates quantitative analysis and computational modeling of detailed experimental data. Digital reconstructions provide the required neuromorphological descriptions in a parsimonious, comprehensive, and reliable numerical format. NeuroMorpho.Org is the largest web-accessible repository service for digitally reconstructed neurons and one of the integrated resources in the Neuroscience Information Framework (NIF). Here we describe the NeuroMorpho.Org approach as an exemplary experience in designing, creating, populating, and curating a neuroscience digital resource. The simple three-tier architecture of NeuroMorpho.Org (web client, web server, and relational database) encompasses all necessary elements to support a large-scale, integrate-able repository. The data content, while heterogeneous in scientific scope and experimental origin, is unified in format and presentation by an in house standardization protocol. The server application (MRALD) is secure, customizable, and developer-friendly. Centralized processing and expert annotation yields a comprehensive set of metadata that enriches and complements the raw data. The thoroughly tested interface design allows for optimal and effective data search and retrieval. Availability of data in both original and standardized formats ensures compatibility with existing resources and fosters further tool development. Other key functions enable extensive exploration and discovery, including 3D and interactive visualization of branching, frequently measured morphometrics, and reciprocal links to the original PubMed publications. The integration of NeuroMorpho.Org with version-1 of the NIF (NIFv1) provides the opportunity to access morphological data in the context of other relevant resources and diverse subdomains of neuroscience, opening

NeuroMorpho.Org implementation of digital neuroscience: dense coverage and integration with the NIF.

PubMed

Halavi, Maryam; Polavaram, Sridevi; Donohue, Duncan E; Hamilton, Gail; Hoyt, Jeffrey; Smith, Kenneth P; Ascoli, Giorgio A

2008-09-01

Neuronal morphology affects network connectivity, plasticity, and information processing. Uncovering the design principles and functional consequences of dendritic and axonal shape necessitates quantitative analysis and computational modeling of detailed experimental data. Digital reconstructions provide the required neuromorphological descriptions in a parsimonious, comprehensive, and reliable numerical format. NeuroMorpho.Org is the largest web-accessible repository service for digitally reconstructed neurons and one of the integrated resources in the Neuroscience Information Framework (NIF). Here we describe the NeuroMorpho.Org approach as an exemplary experience in designing, creating, populating, and curating a neuroscience digital resource. The simple three-tier architecture of NeuroMorpho.Org (web client, web server, and relational database) encompasses all necessary elements to support a large-scale, integrate-able repository. The data content, while heterogeneous in scientific scope and experimental origin, is unified in format and presentation by an in house standardization protocol. The server application (MRALD) is secure, customizable, and developer-friendly. Centralized processing and expert annotation yields a comprehensive set of metadata that enriches and complements the raw data. The thoroughly tested interface design allows for optimal and effective data search and retrieval. Availability of data in both original and standardized formats ensures compatibility with existing resources and fosters further tool development. Other key functions enable extensive exploration and discovery, including 3D and interactive visualization of branching, frequently measured morphometrics, and reciprocal links to the original PubMed publications. The integration of NeuroMorpho.Org with version-1 of the NIF (NIFv1) provides the opportunity to access morphological data in the context of other relevant resources and diverse subdomains of neuroscience, opening

Integrative Functional Genomics for Systems Genetics in GeneWeaver.org.

PubMed

Bubier, Jason A; Langston, Michael A; Baker, Erich J; Chesler, Elissa J

2017-01-01

The abundance of existing functional genomics studies permits an integrative approach to interpreting and resolving the results of diverse systems genetics studies. However, a major challenge lies in assembling and harmonizing heterogeneous data sets across species for facile comparison to the positional candidate genes and coexpression networks that come from systems genetic studies. GeneWeaver is an online database and suite of tools at www.geneweaver.org that allows for fast aggregation and analysis of gene set-centric data. GeneWeaver contains curated experimental data together with resource-level data such as GO annotations, MP annotations, and KEGG pathways, along with persistent stores of user entered data sets. These can be entered directly into GeneWeaver or transferred from widely used resources such as GeneNetwork.org. Data are analyzed using statistical tools and advanced graph algorithms to discover new relations, prioritize candidate genes, and generate function hypotheses. Here we use GeneWeaver to find genes common to multiple gene sets, prioritize candidate genes from a quantitative trait locus, and characterize a set of differentially expressed genes. Coupling a large multispecies repository curated and empirical functional genomics data to fast computational tools allows for the rapid integrative analysis of heterogeneous data for interpreting and extrapolating systems genetics results.

Virtual dermatohistopathology at http://www.pathowiki.org.

PubMed

Roßner, Mathias; Roßner, Florian; Zwönitzer, Ralf; Hofmann, Harald; Sterry, Wolfram; Kalinski, Thomas

2012-04-01

PATHOWIKI (http://www.pathowiki.org) is a new specialized information system in the form of a web-based wiki with content from all sub-disciplines of human pathology. Essential components are articles and specimens which are located thematically in dermatopathology. The project is presented on the basis of impressive examples and possibilities. The ability to link all kinds of content and integrate pattern analysis theories creates an effective tool for teaching and training in dermatopathology. Collaborative work ensures the effective usage of available resources and a continually growing amount of content, the quality of which depends on the number of users and should be as high as possible. Therefore, all interested colleagues are invited to support the project. © The Authors • Journal compilation © Blackwell Verlag GmbH, Berlin.

Hippocampome.org: a knowledge base of neuron types in the rodent hippocampus.

PubMed

Wheeler, Diek W; White, Charise M; Rees, Christopher L; Komendantov, Alexander O; Hamilton, David J; Ascoli, Giorgio A

2015-09-24

Hippocampome.org is a comprehensive knowledge base of neuron types in the rodent hippocampal formation (dentate gyrus, CA3, CA2, CA1, subiculum, and entorhinal cortex). Although the hippocampal literature is remarkably information-rich, neuron properties are often reported with incompletely defined and notoriously inconsistent terminology, creating a formidable challenge for data integration. Our extensive literature mining and data reconciliation identified 122 neuron types based on neurotransmitter, axonal and dendritic patterns, synaptic specificity, electrophysiology, and molecular biomarkers. All ∼3700 annotated properties are individually supported by specific evidence (∼14,000 pieces) in peer-reviewed publications. Systematic analysis of this unprecedented amount of machine-readable information reveals novel correlations among neuron types and properties, the potential connectivity of the full hippocampal circuitry, and outstanding knowledge gaps. User-friendly browsing and online querying of Hippocampome.org may aid design and interpretation of both experiments and simulations. This powerful, simple, and extensible neuron classification endeavor is unique in its detail, utility, and completeness.

Exercises in Anatomy, Connectivity, and Morphology using Neuromorpho.org and the Allen Brain Atlas.

PubMed

Chu, Philip; Peck, Joshua; Brumberg, Joshua C

2015-01-01

Laboratory instruction of neuroscience is often limited by the lack of physical resources and supplies (e.g., brains specimens, dissection kits, physiological equipment). Online databases can serve as supplements to material labs by providing professionally collected images of brain specimens and their underlying cellular populations with resolution and quality that is extremely difficult to access for strictly pedagogical purposes. We describe a method using two online databases, the Neuromorpho.org and the Allen Brain Atlas (ABA), that freely provide access to data from working brain scientists that can be modified for laboratory instruction/exercises. Neuromorpho.org is the first neuronal morphology database that provides qualitative and quantitative data from reconstructed cells analyzed in published scientific reports. The Neuromorpho.org database contains cross species and multiple neuronal phenotype datasets which allows for comparative examinations. The ABA provides modules that allow students to study the anatomy of the rodent brain, as well as observe the different cellular phenotypes that exist using histochemical labeling. Using these tools in conjunction, advanced students can ask questions about qualitative and quantitative neuronal morphology, then examine the distribution of the same cell types across the entire brain to gain a full appreciation of the magnitude of the brain's complexity.

EarthRef.org: Exploring aspects of a Cyber Infrastructure in Earth Science and Education

NASA Astrophysics Data System (ADS)

Staudigel, H.; Koppers, A.; Tauxe, L.; Constable, C.; Helly, J.

2004-12-01

EarthRef.org is the common host and (co-) developer of a range of earth science databases and IT resources providing a test bed for a Cyberinfrastructure in Earth Science and Education (CIESE). EarthRef.org data base efforts include in particular the Geochemical Earth Reference Model (GERM), the Magnetics Information Consortium (MagIC), the Educational Resources for Earth Science Education (ERESE) project, the Seamount Catalog, the Mid-Ocean Ridge Catalog, the Radio-Isotope Geochronology (RiG) initiative for CHRONOS, and the Microbial Observatory for Fe oxidizing microbes on Loihi Seamount (FeMO; the most recent development). These diverse databases are developed under a single database umbrella and webserver at the San Diego Supercomputing Center. All the data bases have similar structures, with consistent metadata concepts, a common database layout, and automated upload wizards. Shared resources include supporting databases like an address book, a reference/publication catalog, and a common digital archive making database development and maintenance cost-effective, while guaranteeing interoperability. The EarthRef.org CIESE provides a common umbrella for synthesis information as well as sample-based data, and it bridges the gap between science and science education in middle and high schools, validating the potential for a system wide data infrastructure in a CIESE. EarthRef.org experiences have shown that effective communication with the respective communities is a key part of a successful CIESE facilitating both utility and community buy-in. GERM has been particularly successful at developing a metadata scheme for geochemistry and in the development of a new electronic journal (G-cubed) that has made much progress in data publication and linkages between journals and community data bases. GERM also has worked, through editors and publishers, towards interfacing databases with the publication process, to accomplish a more scholarly and database friendly data

Translational PK-PD modelling of molecular target modulation for the AMPA receptor positive allosteric modulator Org 26576.

PubMed

Bursi, Roberta; Erdemli, Gul; Campbell, Robert; Hutmacher, Matthew M; Kerbusch, Thomas; Spanswick, David; Jeggo, Ross; Nations, Kari R; Dogterom, Peter; Schipper, Jacques; Shahid, Mohammed

2011-12-01

The α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor potentiator Org 26576 represents an interesting pharmacological tool to evaluate the utility of glutamatergic enhancement towards the treatment of psychiatric disorders. In this study, a rat-human translational pharmacokinetic-pharmacodynamic (PK-PD) model of AMPA receptor modulation was used to predict human target engagement and inform dose selection in efficacy clinical trials. Modelling and simulation was applied to rat plasma and cerebrospinal fluid (CSF) pharmacokinetic and pharmacodynamic measurements to identify a target concentration (EC(80)) for AMPA receptor modulation. Human plasma pharmacokinetics was determined from 33 healthy volunteers and eight major depressive disorder patients. From four out of these eight patients, CSF PK was also determined. Simulations of human CSF levels were performed for several doses of Org 26576. Org 26576 (0.1-10 mg/kg, i.v.) potentiated rat hippocampal AMPA receptor responses in an exposure-dependant manner. The rat plasma and CSF PK data were fitted by one-compartment model each. The rat CSF PK-PD model yielded an EC(80) value of 593 ng/ml (90% confidence interval 406.8, 1,264.1). The human plasma and CSF PK data were simultaneously well described by a two-compartment model. Simulations showed that in humans at 100 mg QD, CSF levels of Org 26576 would exceed the EC(80) target concentration for about 2 h and that 400 mg BID would engage AMPA receptors for 24 h. The modelling approach provided useful insight on the likely human dose-molecular target engagement relationship for Org 26576. Based on the current analysis, 100 and 400 mg BID would be suitable to provide 'phasic' and 'continuous' AMPA receptor engagement, respectively.

Evaluating virtual STEM mentoring programs: The SAGANet.org experience

NASA Astrophysics Data System (ADS)

Som, S. M.; Walker, S. I.; Miller, E.; Anbar, M.; Kacar, B.; Forrester, J. H.

2014-12-01

Many school districts within the United States continue to seek new ways of engaging students within Science, Technology, Engineering, and Mathematics (STEM) disciplines. SAGANet.org, a web-based 501c3 Astrobiology outreach initiative, works with a number of schools, partnering K-12 students and their families with professional scientist mentors from around the world to teach and inspire students using virtual technology platforms. Current programs include two mentoring partnerships: pairing scientist-mentors with at-risk youth at the Pittsburg Community School in Pittsburg CA, and pairing scientist-mentors with families from the Kyrene del Cielo Elementary School in Chandler AZ. These programs represent two very different models for utilizing the virtual media platform provided by SAGANet.org to engage K-12 students and their families in STEM. For the former, scientists mentor the students of the Pittsburg School as part of the formal in-class curriculum. For the latter, scientists work with K-5 students and their families through Cielo's Science & Engineering Discovery Room to develop a science project as part of an informal learning experience that is independent of the formal curriculum. In this presentation, we (1) discuss the challenges and successes of engaging these two distinct audiences through virtual media, (2) present the results of how these two very-different mentoring partnership impact K-12 students science self-efficacy, interest in science, and STEM career awareness, and (3) share the impact of the mentoring experience on the mentor's confidence and self-efficacy with communicating science to the public.

Starstuff.org - Bridging the Cosmos Between Astronomers and the Public

NASA Astrophysics Data System (ADS)

Hamm, J. J.; Howell, D. A.

1998-12-01

Starstuff.org is a new web site featuring articles written by astronomers to promote general interest in astronomy and communicate directly the ideas and excitement that make astronomy popular with the public. Traditional media are limited as an outreach tool, because journalists and publishers decide which topics are newsworthy, and many facts are lost in the translation. Starstuff.org circumvents these problems by removing the middleman and allowing astronomers to communicate with the public directly. Readers can be assured of getting accurate information through the firsthand accounts of leaders in the field. This format also allows for the discussion of astronomical concepts and issues that may be important to astronomers but not considered newsworthy by journalists. The unique power of the computers and the internet as instructive tools is harnessed with features such as virtual reality (VRML) explorations of 3D concepts, interactive equations, animations to explain dynamic events, and hyperlinks to emphasize the connections between concepts and direct the reader to further resources. Topics may be explored in more creative ways and in greater depth than in traditional media, and astronomers can reach a wider audience than they could in a traditional lecture. The site's infrastructure, automated processing, and professional programmer/digital artist free contributors from having to know HTML, allowing them to concentrate on creative ways of presenting ideas. Any astronomer with email is encouraged to contribute.

Acute and subchronic effects of Org 2305 and diazepam on psychomotor performance in man.

PubMed

Mattila, M J; Koski, J; Strömberg, C

1987-02-01

Three doses (15, 30 and 60 mg) of Org 2305 (O 15, O 30 and O 60 respectively), a novel anxiolytic drug chemically related to mianserin, were compared with placebo and 15 mg diazepam (DZ) on human psychomotor performance in a double-blind, cross-over study with 15 healthy volunteers. Objective measurements (choice reaction, tracking, flicker fusion, Maddox wing, digit symbol substitution, memory recall) and subjective assessments (visual analogue scales) were done at baseline and 2 and 13 h after the first dose. This testing procedure was repeated on day 7 when administering the seventh consecutive daily night-time dose. After the first dose O 15 did not differ from placebo and O 30 rarely differed from placebo. O 60 impaired various objective functions similarly to, or less than DZ. Subjectively, DZ and O 60 were felt as sedative. During subchronic treatment, DZ caused some impairment of baseline due to accumulation of bioassayable benzodiazepines, but significant responses to the last DZ dose were less than those to the first dose. DZ but not O 60 was reported to have caused lethargy and clumsiness during subchronic treatment. In the doses used Org 2305 impaired psychomotor performance less than diazepam did. A dose of 60 mg Org 2305 may offer some advantage over 15 mg diazepam, provided that their anxiolytic effects are about similar.

NucleusHUB.org: A Platform for Collaboration Among Astronomers, Nuclear Astrophysicists, and Planetary Scientists

NASA Astrophysics Data System (ADS)

Meyer, B. S.

2018-04-01

The author and collaborators are developing nucleusHUB.org, built with HUBzero technology, to facilitate interaction among astronomers, nuclear astrophysicists, and planetary scientists. The site allows users to collaborate and publish online tools.

The AMPA receptor potentiator Org 26576 modulates stress-induced transcription of BDNF isoforms in rat hippocampus.

PubMed

Fumagalli, Fabio; Calabrese, Francesca; Luoni, Alessia; Shahid, Mohammed; Racagni, Giorgio; Riva, Marco A

2012-02-01

Brain derived neurotrophic factor (BDNF) is a key mediator of brain plasticity. The modulation of its expression and function is important for cognition and represents a key strategy to enhance neuronal resilience. Within this context, there exists a close interaction between glutamatergic neurotransmission and BDNF activity towards regulating cellular homeostasis and plasticity. The aim of the current study was to investigate the ability of the AMPA receptor potentiator Org 26576 to modulate BDNF expression in selected brain regions under basal conditions or in response to an acute swim stress. Rats subjected to a single intraperitoneal injection with Org 26576 (10mg/kg) or saline were exposed to a swim stress session (5 min) and sacrificed 15 min after the end of stress. Real-time PCR assay was used to determine changes in BDNF transcription in different brain regions. Total BDNF mRNA levels were significantly increased in the hippocampus of animals exposed to the combination of Org 26576 and stress whereas, in prefrontal and frontal cortices, BDNF mRNA levels were modulated by the acute stress, independently from drug treatment. The analysis of BDNF transcripts in the hippocampus revealed a major contribution of exons I and IV. Our results suggest that AMPA receptor potentiation by Org 26576 exerts a positive modulatory influence on BDNF expression during ongoing neuronal activity. Given that these mechanisms are critical for neuronal plasticity, we hypothesized that such changes may facilitate learning/coping mechanisms associated with a mild stressful experience. Copyright © 2011 Elsevier Ltd. All rights reserved.

Radiosynthesis and radiopharmacological evaluation of [N-methyl-11C]Org 34850 as a glucocorticoid receptor (GR)-binding radiotracer.

PubMed

Wuest, Frank; Kniess, Torsten; Henry, Brian; Peeters, Bernardus W M M; Wiegerinck, Peter H G; Pietzsch, Jens; Bergmann, Ralf

2009-02-01

The radiosynthesis of [N-methyl-(11)C]Org 34850 as a potential brain glucocorticoid receptor (GR)-binding radiotracer is described. The radiosynthesis was accomplished via N-methylation of the corresponding desmethyl precursor with [(11)C]methyl triflate in a remotely controlled synthesis module to give the desired compound in a radiochemical yield of 23+/-5% (decay-corrected, based upon [(11)C]CO(2)) at a specific activity of 47+/-12 GBq/micromol (n=15) at the end-of-synthesis (EOS). The radiochemical purity after semi-preparative HPLC purification exceeded 95%. The total synthesis time was 35-40 min after end-of-bombardment (EOB). The radiotracer is rapidly metabolized in rat plasma leading to the formation of two more hydrophilic metabolites as the major metabolites. Radiopharmacological evaluation involving biodistribution and small animal PET imaging in normal Wistar rats showed that the compound [N-methyl-(11)C]Org 34850 is not able to sufficiently penetrate the blood-brain barrier. Therefore, compound [N-methyl-(11)C]Org 34850 seems not to be a suitable PET radiotracer for imaging rat brain GRs. However, involvement of Pgp or species differences requires further clarification to establish whether the radiotracer [N-methyl-(11)C]Org 34850 may still represent a suitable candidate for imaging GRs in humans.

Approaches to Linked Open Data at data.oceandrilling.org

NASA Astrophysics Data System (ADS)

Fils, D.

2012-12-01

The data.oceandrilling.org web application applies Linked Open Data (LOD) patterns to expose Deep Sea Drilling Project (DSDP), Ocean Drilling Program (ODP) and Integrated Ocean Drilling Program (IODP) data. Ocean drilling data is represented in a rich range of data formats: high resolution images, file based data sets and sample based data. This richness of data types has been well met by semantic approaches and will be demonstrated. Data has been extracted from CSV, HTML and RDBMS through custom software and existing packages for loading into a SPARQL 1.1 compliant triple store. Practices have been developed to streamline the maintenance of the RDF graphs and properly expose them using LOD approaches like VoID and HTML embedded structured data. Custom and existing vocabularies are used to allow semantic relations between resources. Use of the W3c draft RDF Data Cube Vocabulary and other approaches for encoding time scales, taxonomic fossil data and other graphs will be shown. A software layer written in Google Go mediates the RDF to web pipeline. The approach used is general and can be applied to other similar environments like node.js or Python Twisted. To facilitate communication user interface software libraries such as D3 and packages such as S2S and LodLive have been used. Additionally OpenSearch API's, structured data in HTML and SPARQL endpoints provide various access methods for applications. The data.oceandrilling.org is not viewed as a web site but as an application that communicate with a range of clients. This approach helps guide the development more along software practices than along web site authoring approaches.

Dcode.org anthology of comparative genomic tools.

PubMed

Loots, Gabriela G; Ovcharenko, Ivan

2005-07-01

Comparative genomics provides the means to demarcate functional regions in anonymous DNA sequences. The successful application of this method to identifying novel genes is currently shifting to deciphering the non-coding encryption of gene regulation across genomes. To facilitate the practical application of comparative sequence analysis to genetics and genomics, we have developed several analytical and visualization tools for the analysis of arbitrary sequences and whole genomes. These tools include two alignment tools, zPicture and Mulan; a phylogenetic shadowing tool, eShadow for identifying lineage- and species-specific functional elements; two evolutionary conserved transcription factor analysis tools, rVista and multiTF; a tool for extracting cis-regulatory modules governing the expression of co-regulated genes, Creme 2.0; and a dynamic portal to multiple vertebrate and invertebrate genome alignments, the ECR Browser. Here, we briefly describe each one of these tools and provide specific examples on their practical applications. All the tools are publicly available at the http://www.dcode.org/ website.

A translational approach to evaluate the efficacy and safety of the novel AMPA receptor positive allosteric modulator org 26576 in adult attention-deficit/hyperactivity disorder.

PubMed

Adler, Lenard A; Kroon, René A; Stein, Mark; Shahid, Mohammed; Tarazi, Frank I; Szegedi, Armin; Schipper, Jacques; Cazorla, Pilar

2012-12-01

It has been posited that glutamate dysregulation contributes to the pathophysiology of attention-deficit/hyperactivity disorder (ADHD). Modulation of glutamate neurotransmission may provide alternative therapeutic options. The novel 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor positive allosteric modulator Org 26576 was investigated with a translational approach including preclinical and clinical testing. Neonatal rat 6-hydroxydopamine lesion-induced hyperactivity was used as preclinical model. Seventy-eight ADHD adults entered a multicenter, double-blind, placebo-controlled, two-period crossover trial. After 1 week placebo lead-in, 67 subjects were randomized into one of four treatment sequences: sequence A (n = 15) Org 26576 (100 mg b.i.d.) for 3 weeks, followed by a 2-week placebo crossover and 3 weeks placebo; sequence B (n = 16) 5 weeks placebo followed by 3 weeks Org 26576 (100 mg b.i.d.); sequence C (n = 18) Org 26576 flexible dose (100-300 mg b.i.d.) for 3 weeks, then 5 weeks placebo; sequence D (n = 18) 5 weeks placebo followed by 3 weeks Org 26576 (100-300 mg b.i.d.). The Adult ADHD Investigator Symptom Rating Scale was used to assess changes in ADHD symptomatology. Org 26576 (1, 3, 10 mg/kg intraperitoneal) produced dose-dependent inhibition of locomotor hyperactivity in 6-hydroxydopamine-lesioned rats. Org 26576 (100 mg b.i.d.) was superior to placebo in treating symptoms of adult ADHD subjects. The primary Adult ADHD Investigator Symptom Rating Scale results were supported by some secondary analyses. However, Org 26576 (100-300 mg b.i.d.) did not confirm these results. Most frequently reported adverse events were nausea, dizziness, and headache. These preclinical and clinical findings suggest that Org 25676 may have utility in the treatment of ADHD. Copyright © 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

TheCellMap.org: A Web-Accessible Database for Visualizing and Mining the Global Yeast Genetic Interaction Network

PubMed Central

Usaj, Matej; Tan, Yizhao; Wang, Wen; VanderSluis, Benjamin; Zou, Albert; Myers, Chad L.; Costanzo, Michael; Andrews, Brenda; Boone, Charles

2017-01-01

Providing access to quantitative genomic data is key to ensure large-scale data validation and promote new discoveries. TheCellMap.org serves as a central repository for storing and analyzing quantitative genetic interaction data produced by genome-scale Synthetic Genetic Array (SGA) experiments with the budding yeast Saccharomyces cerevisiae. In particular, TheCellMap.org allows users to easily access, visualize, explore, and functionally annotate genetic interactions, or to extract and reorganize subnetworks, using data-driven network layouts in an intuitive and interactive manner. PMID:28325812

HealthMpowerment.org: Building Community through a Mobile-Optimized, Online Health Promotion Intervention

ERIC Educational Resources Information Center

Hightow-Weidman, Lisa B.; Muessig, Kathryn E.; Pike, Emily C.; LeGrand, Sara; Baltierra, Nina; Rucker, Alvin Justin; Wilson, Patrick

2015-01-01

Background: Both young Black men who have sex with men as well as young Black transgender women (YBMSM/TW) continue to experience a significant increase in HIV incidence. HealthMpowerment.org (HMP) is a mobile phone-optimized, online intervention for both YBMSM/TW to build community and facilitate supportive relationships. Methods: To assess the…

Cogito.org: A Website and Online Community for the World's Most Talented Youth

ERIC Educational Resources Information Center

Brody, Linda E.

2008-01-01

Students have used Cogito.org to pose and/or solve math problems and brain teasers, share their experiences in academic competitions, debate the pros and cons of using biofuels for energy, design an alien world based on sound scientific principles, and expand their cultural understanding by connecting with students from around the world.…

DNATCO: assignment of DNA conformers at dnatco.org.

PubMed

Černý, Jiří; Božíková, Paulína; Schneider, Bohdan

2016-07-08

The web service DNATCO (dnatco.org) classifies local conformations of DNA molecules beyond their traditional sorting to A, B and Z DNA forms. DNATCO provides an interface to robust algorithms assigning conformation classes called NTC: to dinucleotides extracted from DNA-containing structures uploaded in PDB format version 3.1 or above. The assigned dinucleotide NTC: classes are further grouped into DNA structural alphabet NTA: , to the best of our knowledge the first DNA structural alphabet. The results are presented at two levels: in the form of user friendly visualization and analysis of the assignment, and in the form of a downloadable, more detailed table for further analysis offline. The website is free and open to all users and there is no login requirement. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Concerthalls.org: A webpage for architectural acoustics education

NASA Astrophysics Data System (ADS)

Wang, Lily M.; Hall, Jessica M.

2002-11-01

A website focusing on concert hall acoustics (www.concerthalls.org) has been developed under the Schultz Grant from the Newman Student Award Fund. The website includes historical information, discussions on a variety of architectural acoustical measures, links to other websites of interest including a collection of concert hall webpages, and a comprehensive reference list. Of particular interest are the many listening examples provided on the website, which help students and other visitors to understand each subjective quality audibly and give insight on how to measure and control the associated objective measure. Examples are provided for reverberation, clarity, intimacy, warmth, loudness, and spaciousness. Various samples will be played during this presentation. Instructors of architectural acoustics are encouraged to introduce the site to their students and incorporate it into their instructional materials. [Work supported by Schultz Grant from the Newman Student Award Fund.

Online collaboration and model sharing in volcanology via VHub.org

NASA Astrophysics Data System (ADS)

Valentine, G.; Patra, A. K.; Bajo, J. V.; Bursik, M. I.; Calder, E.; Carn, S. A.; Charbonnier, S. J.; Connor, C.; Connor, L.; Courtland, L. M.; Gallo, S.; Jones, M.; Palma Lizana, J. L.; Moore-Russo, D.; Renschler, C. S.; Rose, W. I.

2013-12-01

VHub (short for VolcanoHub, and accessible at vhub.org) is an online platform for barrier free access to high end modeling and simulation and collaboration in research and training related to volcanoes, the hazards they pose, and risk mitigation. The underlying concept is to provide a platform, building upon the successful HUBzero software infrastructure (hubzero.org), that enables workers to collaborate online and to easily share information, modeling and analysis tools, and educational materials with colleagues around the globe. Collaboration occurs around several different points: (1) modeling and simulation; (2) data sharing; (3) education and training; (4) volcano observatories; and (5) project-specific groups. VHub promotes modeling and simulation in two ways: (1) some models can be implemented on VHub for online execution. VHub can provide a central warehouse for such models that should result in broader dissemination. VHub also provides a platform that supports the more complex CFD models by enabling the sharing of code development and problem-solving knowledge, benchmarking datasets, and the development of validation exercises. VHub also provides a platform for sharing of data and datasets. The VHub development team is implementing the iRODS data sharing middleware (see irods.org). iRODS allows a researcher to access data that are located at participating data sources around the world (a cloud of data) as if the data were housed in a single virtual database. Projects associated with VHub are also going to introduce the use of data driven workflow tools to support the use of multistage analysis processes where computing and data are integrated for model validation, hazard analysis etc. Audio-video recordings of seminars, PowerPoint slide sets, and educational simulations are all items that can be placed onto VHub for use by the community or by selected collaborators. An important point is that the manager of a given educational resource (or any other

TheCellMap.org: A Web-Accessible Database for Visualizing and Mining the Global Yeast Genetic Interaction Network.

PubMed

Usaj, Matej; Tan, Yizhao; Wang, Wen; VanderSluis, Benjamin; Zou, Albert; Myers, Chad L; Costanzo, Michael; Andrews, Brenda; Boone, Charles

2017-05-05

Providing access to quantitative genomic data is key to ensure large-scale data validation and promote new discoveries. TheCellMap.org serves as a central repository for storing and analyzing quantitative genetic interaction data produced by genome-scale Synthetic Genetic Array (SGA) experiments with the budding yeast Saccharomyces cerevisiae In particular, TheCellMap.org allows users to easily access, visualize, explore, and functionally annotate genetic interactions, or to extract and reorganize subnetworks, using data-driven network layouts in an intuitive and interactive manner. Copyright © 2017 Usaj et al.

A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569.

PubMed

Fay, Jonathan F; Farrens, David L

2012-09-28

Allosteric ligands that modulate how G protein-coupled receptors respond to traditional orthosteric drugs are an exciting and rapidly expanding field of pharmacology. An allosteric ligand for the cannabinoid receptor CB1, Org 27569, exhibits an intriguing effect; it increases agonist binding, yet blocks agonist-induced CB1 signaling. Here we explored the mechanism behind this behavior, using a site-directed fluorescence labeling approach. Our results show that Org 27569 blocks conformational changes in CB1 that accompany G protein binding and/or activation, and thus inhibit formation of a fully active CB1 structure. The underlying mechanism behind this behavior is that simultaneous binding of Org 27569 produces a unique agonist-bound conformation, one that may resemble an intermediate structure formed on the pathway to full receptor activation.

DCODE.ORG Anthology of Comparative Genomic Tools

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loots, G G; Ovcharenko, I

2005-01-11

Comparative genomics provides the means to demarcate functional regions in anonymous DNA sequences. The successful application of this method to identifying novel genes is currently shifting to deciphering the noncoding encryption of gene regulation across genomes. To facilitate the use of comparative genomics to practical applications in genetics and genomics we have developed several analytical and visualization tools for the analysis of arbitrary sequences and whole genomes. These tools include two alignment tools: zPicture and Mulan; a phylogenetic shadowing tool: eShadow for identifying lineage- and species-specific functional elements; two evolutionary conserved transcription factor analysis tools: rVista and multiTF; a toolmore » for extracting cis-regulatory modules governing the expression of co-regulated genes, CREME; and a dynamic portal to multiple vertebrate and invertebrate genome alignments, the ECR Browser. Here we briefly describe each one of these tools and provide specific examples on their practical applications. All the tools are publicly available at the http://www.dcode.org/ web site.« less

www.elearnSCI.org: a global educational initiative of ISCoS.

PubMed

Chhabra, H S; Harvey, L A; Muldoon, S; Chaudhary, S; Arora, M; Brown, D J; Biering-Sorensen, F; Wyndaele, J J; Charlifue, S; Horsewell, J; Ducharme, S; Green, D; Simpson, D; Glinsky, J; Weerts, E; Upadhyay, N; Aito, S; Wing, P; Katoh, S; Kovindha, A; Krassioukov, A; Weeks, C; Srikumar, V; Reeves, R; Siriwardane, C; Hasnan, N; Kalke, Y B; Lanig, I

2013-03-01

To develop a web-based educational resource for health professionals responsible for the management of spinal cord injury (SCI). The resource:www.elearnSCI.org is comprised of seven learning modules, each subdivided into various submodules. Six of the seven modules address the educational needs of all disciplines involved in comprehensive SCI management. The seventh module addresses prevention of SCI. Each submodule includes an overview, activities, self-assessment questions and references. Three hundred and thirty-two experts from The International Spinal Cord Society (ISCoS) and various affiliated societies from 36 countries were involved in developing the resource through 28 subcommittees. The content of each submodule was reviewed and approved by the Education and Scientific Committees of ISCoS and finally by an Editorial Committee of 23 experts. The content of the learning modules is relevant to students and to new as well as experienced SCI healthcare professionals. The content is applicable globally, has received consumer input and is available at no cost. The material is presented on a website underpinned by a sophisticated content-management system, which allows easy maintenance and ready update of all the content. The resource conforms to key principles of e-learning, including appropriateness of curriculum, engagement of learners, innovative approaches, effective learning, ease of use, inclusion, assessment, coherence, consistency, transparency, cost effectiveness and feedback. www.elearnSCI.org provides a cost effective way of training healthcare professionals that goes beyond the textbook and traditional face-to-face teaching.

Lessons from Afar: A Review of www.daisakuikeda.org, Official Website of Daisaku Ikeda

ERIC Educational Resources Information Center

Arauz, Luis

2012-01-01

Daisaku Ikeda (1928- ) is a Buddhist leader, peace builder, school founder, and poet. His own biography and lifework provide a model for how one can transform adversity into alternative opportunities for some of the most disenfranchised students. Scrutinizing Ikeda's official website (www.daisakuikeda.org) reveals an extensive collection of his…

The ampakine, Org 26576, bolsters early spatial reference learning and retrieval in the Morris water maze: a subchronic, dose-ranging study in rats.

PubMed

Hamlyn, Eugene; Brand, Linda; Shahid, Mohammed; Harvey, Brian H

2009-10-01

Ampakines have shown beneficial effects on cognition in selected animal models of learning. However, their ability to modify long-term spatial memory tasks has not been studied yet. This would lend credence to their possible value in treating disorders of cognition. We evaluated the actions of subchronic Org 26576 administration on spatial reference memory performance in the 5-day Morris water maze task in male Sprague-Dawley rats, at doses of 1, 3 and 10 mg/kg twice daily through intraperitoneal injection over 12 days. Org 26576 exerted a dose and time-dependent effect on spatial learning, with dosages of 3 and 10 mg/kg significantly enhancing acquisition on day 1. Globally, escape latency decreased significantly as the training days progressed in the saline and Org 26576-treated groups, indicating that significant and equal learning had taken place over the learning period. However, at the end of the learning period, all doses of Org 26576 significantly improved spatial memory storage/retrieval without confounding effects in the cued version of the task. Org 26576 offers early phase spatial memory benefits in rats, but particularly enhances search accuracy during reference memory retrieval. These results support its possible utility in treating disorders characterized by deficits in cognitive performance.

Donor Retention in Online Crowdfunding Communities: A Case Study of DonorsChoose.org

PubMed Central

Althoff, Tim; Leskovec, Jure

2016-01-01

Online crowdfunding platforms like DonorsChoose.org and Kick-starter allow specific projects to get funded by targeted contributions from a large number of people. Critical for the success of crowdfunding communities is recruitment and continued engagement of donors. With donor attrition rates above 70%, a significant challenge for online crowdfunding platforms as well as traditional offline non-profit organizations is the problem of donor retention. We present a large-scale study of millions of donors and donations on DonorsChoose.org, a crowdfunding platform for education projects. Studying an online crowdfunding platform allows for an unprecedented detailed view of how people direct their donations. We explore various factors impacting donor retention which allows us to identify different groups of donors and quantify their propensity to return for subsequent donations. We find that donors are more likely to return if they had a positive interaction with the receiver of the donation. We also show that this includes appropriate and timely recognition of their support as well as detailed communication of their impact. Finally, we discuss how our findings could inform steps to improve donor retention in crowdfunding communities and non-profit organizations. PMID:27077139

Donor Retention in Online Crowdfunding Communities: A Case Study of DonorsChoose.org.

PubMed

Althoff, Tim; Leskovec, Jure

2015-05-01

Online crowdfunding platforms like DonorsChoose.org and Kick-starter allow specific projects to get funded by targeted contributions from a large number of people. Critical for the success of crowdfunding communities is recruitment and continued engagement of donors. With donor attrition rates above 70%, a significant challenge for online crowdfunding platforms as well as traditional offline non-profit organizations is the problem of donor retention. We present a large-scale study of millions of donors and donations on DonorsChoose.org, a crowdfunding platform for education projects. Studying an online crowdfunding platform allows for an unprecedented detailed view of how people direct their donations. We explore various factors impacting donor retention which allows us to identify different groups of donors and quantify their propensity to return for subsequent donations. We find that donors are more likely to return if they had a positive interaction with the receiver of the donation. We also show that this includes appropriate and timely recognition of their support as well as detailed communication of their impact. Finally, we discuss how our findings could inform steps to improve donor retention in crowdfunding communities and non-profit organizations.

OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders

PubMed Central

Amberger, Joanna S.; Bocchini, Carol A.; Schiettecatte, François; Scott, Alan F.; Hamosh, Ada

2015-01-01

Online Mendelian Inheritance in Man, OMIM®, is a comprehensive, authoritative and timely research resource of curated descriptions of human genes and phenotypes and the relationships between them. The new official website for OMIM, OMIM.org (http://omim.org), was launched in January 2011. OMIM is based on the published peer-reviewed biomedical literature and is used by overlapping and diverse communities of clinicians, molecular biologists and genome scientists, as well as by students and teachers of these disciplines. Genes and phenotypes are described in separate entries and are given unique, stable six-digit identifiers (MIM numbers). OMIM entries have a structured free-text format that provides the flexibility necessary to describe the complex and nuanced relationships between genes and genetic phenotypes in an efficient manner. OMIM also has a derivative table of genes and genetic phenotypes, the Morbid Map. OMIM.org has enhanced search capabilities such as genome coordinate searching and thesaurus-enhanced search term options. Phenotypic series have been created to facilitate viewing genetic heterogeneity of phenotypes. Clinical synopsis features are enhanced with UMLS, Human Phenotype Ontology and Elements of Morphology terms and image links. All OMIM data are available for FTP download and through an API. MIMmatch is a novel outreach feature to disseminate updates and encourage collaboration. PMID:25428349

A user-friendly workflow for analysis of Illumina gene expression bead array data available at the arrayanalysis.org portal.

PubMed

Eijssen, Lars M T; Goelela, Varshna S; Kelder, Thomas; Adriaens, Michiel E; Evelo, Chris T; Radonjic, Marijana

2015-06-30

Illumina whole-genome expression bead arrays are a widely used platform for transcriptomics. Most of the tools available for the analysis of the resulting data are not easily applicable by less experienced users. ArrayAnalysis.org provides researchers with an easy-to-use and comprehensive interface to the functionality of R and Bioconductor packages for microarray data analysis. As a modular open source project, it allows developers to contribute modules that provide support for additional types of data or extend workflows. To enable data analysis of Illumina bead arrays for a broad user community, we have developed a module for ArrayAnalysis.org that provides a free and user-friendly web interface for quality control and pre-processing for these arrays. This module can be used together with existing modules for statistical and pathway analysis to provide a full workflow for Illumina gene expression data analysis. The module accepts data exported from Illumina's GenomeStudio, and provides the user with quality control plots and normalized data. The outputs are directly linked to the existing statistics module of ArrayAnalysis.org, but can also be downloaded for further downstream analysis in third-party tools. The Illumina bead arrays analysis module is available at http://www.arrayanalysis.org . A user guide, a tutorial demonstrating the analysis of an example dataset, and R scripts are available. The module can be used as a starting point for statistical evaluation and pathway analysis provided on the website or to generate processed input data for a broad range of applications in life sciences research.

WormClassroom.org: An Inquiry-Rich Educational Web Portal for Research Resources of "Caenorhabditis elegans"

ERIC Educational Resources Information Center

Lu, Fong-Mei; Eliceiri, Kevin W.; Stewart, James; White, John G.

2007-01-01

The utilization of biology research resources, coupled with a "learning by inquiry" approach, has great potential to aid students in gaining an understanding of fundamental biological principles. To help realize this potential, we have developed a Web portal for undergraduate biology education, WormClassroom.org, based on current research…

OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders.

PubMed

Amberger, Joanna S; Bocchini, Carol A; Schiettecatte, François; Scott, Alan F; Hamosh, Ada

2015-01-01

Online Mendelian Inheritance in Man, OMIM(®), is a comprehensive, authoritative and timely research resource of curated descriptions of human genes and phenotypes and the relationships between them. The new official website for OMIM, OMIM.org (http://omim.org), was launched in January 2011. OMIM is based on the published peer-reviewed biomedical literature and is used by overlapping and diverse communities of clinicians, molecular biologists and genome scientists, as well as by students and teachers of these disciplines. Genes and phenotypes are described in separate entries and are given unique, stable six-digit identifiers (MIM numbers). OMIM entries have a structured free-text format that provides the flexibility necessary to describe the complex and nuanced relationships between genes and genetic phenotypes in an efficient manner. OMIM also has a derivative table of genes and genetic phenotypes, the Morbid Map. OMIM.org has enhanced search capabilities such as genome coordinate searching and thesaurus-enhanced search term options. Phenotypic series have been created to facilitate viewing genetic heterogeneity of phenotypes. Clinical synopsis features are enhanced with UMLS, Human Phenotype Ontology and Elements of Morphology terms and image links. All OMIM data are available for FTP download and through an API. MIMmatch is a novel outreach feature to disseminate updates and encourage collaboration. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila.

PubMed

Boukhatmi, Hadi; Schaub, Christoph; Bataillé, Laetitia; Reim, Ingolf; Frendo, Jean-Louis; Frasch, Manfred; Vincent, Alain

2014-10-01

The T-box transcription factor Tbx1 and the LIM-homeodomain transcription factor Islet1 are key components in regulatory circuits that generate myogenic and cardiogenic lineage diversity in chordates. We show here that Org-1 and Tup, the Drosophila orthologs of Tbx1 and Islet1, are co-expressed and required for formation of the heart-associated alary muscles (AMs) in the abdomen. The same holds true for lineage-related muscles in the thorax that have not been described previously, which we name thoracic alary-related muscles (TARMs). Lineage analyses identified the progenitor cell for each AM and TARM. Three-dimensional high-resolution analyses indicate that AMs and TARMs connect the exoskeleton to the aorta/heart and to different regions of the midgut, respectively, and surround-specific tracheal branches, pointing to an architectural role in the internal anatomy of the larva. Org-1 controls tup expression in the AM/TARM lineage by direct binding to two regulatory sites within an AM/TARM-specific cis-regulatory module, tupAME. The contributions of Org-1 and Tup to the specification of Drosophila AMs and TARMs provide new insights into the transcriptional control of Drosophila larval muscle diversification and highlight new parallels with gene regulatory networks involved in the specification of cardiopharyngeal mesodermal derivatives in chordates. © 2014. Published by The Company of Biologists Ltd.

Effect of and satisfaction with www.elearnSCI.org for training of nurse students: a submodule pilot study.

PubMed

Liu, N; Li, X W; Zhou, M W; Krassioukov, A V; Biering-Sørensen, F

2014-10-01

Interventional training session. To investigate the effect and satisfaction with didactic training using printed text of a submodule of www.elearnSCI.org for nurse students and to assess the answers of each question. A Peking University teaching hospital. Twenty-eight nurse students in two groups (14 in each) were involved. Only group A received a translated print-out of the slides from the 'Nursing management' submodule in www.elearnSCI.org for 1-h self-study before the class. At the beginning of class, both groups were tested using the self assessment questions. Then, a lecture according to the content of this submodule was carried out and afterwards both groups answered the self assessment questions again. Finally, both groups filled in a training course satisfaction questionnaire. At the beginning of the class, the mean score (max 9) of the self assessment in group A was 7.1 ± 1.1, which was significantly higher than that in group B (4.9 ± 1.7, P = 0.001). After the lecture, the mean score of the self assessment in group A had insignificantly increased to 7.4 ± 1.3, whereas in group B it increased significantly to 6.9 ± 0.8 (P < 0.001). The mean score (max 50) of the training course satisfaction questionnaire was 42.8 ± 5.2. Sixty-four percentage of the students indicated that they were very satisfied (overall score ⩾ 42) with the training and no students were unsatisfied (overall score < 30). Self-study and lecture presentation are effective methods for training the content of www.elearnSCI.org to nurse students. The training satisfaction of this submodule within the www.elearnSCI.org is favorable.

DLSanalysis.org: a web interface for analysis of dynamic light scattering data.

PubMed

Hansen, Steen

2018-03-01

A web interface ( www.DLSanalysis.org ) for indirect Laplace transformation of dynamic light scattering data is presented. When experimental data are uploaded to the server they are processed in a few seconds, and the result is displayed on the screen in the form of a size distribution together with the experimental data and the fit to the data. No other user input than the experimental data is necessary, but various options for the analysis may be selected. No local installation of software or registration is necessary. The result of the analysis can be downloaded.

Global Soil Information Facilities - Component Worldgrids.org

NASA Astrophysics Data System (ADS)

Reuter, H. I.; Hengl, T.

2012-04-01

GSIF (Global Soil Information Facilities) is ISRIC's framework for production of open soil data. It has been inspired by global environmental data initiatives (e.g. oneGeology, GBIF). The main practical motivation for GSIF is to build cyber-infrastructure to collate legacy (i.e., historic) soil data currently under threat of being lost forever and to generate new soil information. The objective of the component worldgrids is a (de)-central repository for collecting, storing, accessing and interacting with gridded data sets of global soil covariate data for production mapping, while being part of a larger GSIF. It is the physical implementation of the expectation that ISRIC would lead and coordinate a project to assemble a core data set of global environmental covariates to (partly) support local efforts to produce global soil property maps. Currently over 100 layers with a 5 and 1 km resolution with a global coverage can be accessed via www.worldgrids.org. Three different functionalities are implemented to extract data in an OGC complained matter: i) single point overlay ii) mass point overlay; iii) zone grid overlay with reporting of different statistical parameters. The presentation will focus on datasets, functionalities, access via the R-project and ArcGIS globalsoilmap.net Toolbox as well on future enhancements to the worldgrids platform.

Report and Analysis of Web Portal oldagesolutions.org for Indian Old Age Persons.

PubMed

Meher, Sushil Kumar; Dey, A B

2017-01-01

Oldagesolutions.org is a web portal for older persons in india created as apart of Technology Interventations for Elderly (TIE) intitated by the science and society division for benefit of elderly people keeping in view of the National Policy on Older People (NPOP). This is a collative effort of the multidisplinary team at All India Institute of Medical Sciences (AIIMS) comprising of doctors, genetic nurses, netritionist and physiotherapists who provide their valuable collective insights for an elderly centric approach.

Alzheimer's Prevention Education: If We Build It, Will They Come? www.AlzU.org.

PubMed

Isaacson, R S; Haynes, N; Seifan, A; Larsen, D; Christiansen, S; Berger, J C; Safdieh, J E; Lunde, A M; Luo, A; Kramps, M; McInnis, M; Ochner, C N

2014-01-01

Internet-based educational interventions may be useful for impacting knowledge and behavioral change. However, in AD prevention, little data exists about which educational tools work best in terms of learning and interest in participating in clinical trials. Primary: Assess effectiveness of interactive webinars vs. written blog-posts on AD prevention learning. Secondary: Evaluate the effect of AD prevention education on interest in participating in clinical trials; Assess usability of, and user perceptions about, an online AD education research platform; Classify target populations (demographics, learning needs, interests). Observational. Online. Men/Women, aged 25+, recruited via facebook.com. Alzheimer's Universe (www.AlzU.org) education research platform. Pre/post-test performance, self-reported Likert-scale ratings, completion rates. Over two-weeks, 4268 visits were generated. 503 signed-up for a user account (11.8% join rate), 196 participated in the lessons (39.0%) and 100 completed all beta-testing steps (19.9%). Users randomized to webinar instruction about AD prevention and the stages of AD demonstrated significant increases (p=0.01) in pre vs. post-testing scores compared to blog-post intervention. Upon joining, 42% were interested in participating in a clinical trial in AD prevention. After completing all beta-test activities, interest increased to 86%. Users were primarily women and the largest category was children of AD patients. 66.3% joined to learn more about AD prevention, 65.3% to learn more about AD treatment. Webinar-based education led to significant improvements in learning about AD prevention and the stages of AD. AlzU.org participation more than doubled interest in AD prevention clinical trial participation. Subjects were quickly and cost-effectively recruited, and highly satisfied with the AD education research platform. Based on these data, we will further refine AlzU.org prior to public launch and aim to study the effectiveness of 25

Efficacy and safety of the glycine transporter-1 inhibitor org 25935 for the prevention of relapse in alcohol-dependent patients: a randomized, double-blind, placebo-controlled trial.

PubMed

de Bejczy, Andrea; Nations, Kari R; Szegedi, Armin; Schoemaker, Joep; Ruwe, Frank; Söderpalm, Bo

2014-09-01

Org 25935 is a glycine transporter inhibitor that increases extracellular glycine levels and attenuates alcohol-induced dopaminergic activity in the nucleus accumbens. In animal models, Org 25935 has dose-dependent effects on ethanol intake, preference, and relapse-like behavior without tolerance. The current study aimed to translate these animal findings to humans by examining whether Org 25935 prevents relapse in detoxified alcohol-dependent patients. This was a multicenter, randomized, double-blind, placebo-controlled clinical trial. Adult patients diagnosed with alcohol dependence were randomly assigned to receive Org 25935 12 mg twice a day or placebo for 84 days. The primary end point was percentage heavy drinking days (defined as ≥ 5 standard drinks per day for men and ≥ 4 for women). Secondary end points included other measures of relapse-related drinking behavior (e.g., drinks per day, time to relapse), as well as measures of global functioning, alcohol-related thoughts and cravings, and motivation. A total of 140 subjects were included in the intent-to-treat analysis. The trial was stopped approximately midway after a futility analysis showing that the likelihood of detecting a signal at study term was <40%. There was no significant difference between Org 25935 and placebo on percentage heavy drinking days or any other measure of relapse-related drinking behavior. Org 25935 showed no safety issues and was fairly well tolerated, with fatigue, dizziness, and transient visual events as the most commonly occurring side effects. Org 25935 demonstrated no benefit over placebo in preventing alcohol relapse. Study limitations and implications are discussed. Copyright © 2014 by the Research Society on Alcoholism.

Medical and Transmission Vector Vocabulary Alignment with Schema.org

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, William P.; Chappell, Alan R.; Corley, Courtney D.

Available biomedical ontologies and knowledge bases currently lack formal and standards-based interconnections between disease, disease vector, and drug treatment vocabularies. The PNNL Medical Linked Dataset (PNNL-MLD) addresses this gap. This paper describes the PNNL-MLD, which provides a unified vocabulary and dataset of drug, disease, side effect, and vector transmission background information. Currently, the PNNL-MLD combines and curates data from the following research projects: DrugBank, DailyMed, Diseasome, DisGeNet, Wikipedia Infobox, Sider, and PharmGKB. The main outcomes of this effort are a dataset aligned to Schema.org, including a parsing framework, and extensible hooks ready for integration with selected medical ontologies. The PNNL-MLDmore » enables researchers more quickly and easily to query distinct datasets. Future extensions to the PNNL-MLD will include Traditional Chinese Medicine, broader interlinks across genetic structures, a larger thesaurus of synonyms and hypernyms, explicit coding of diseases and drugs across research systems, and incorporating vector-borne transmission vocabularies.« less

Urban and agricultural contribution of annual loads of glyphosate and AMPA towards surface waters at the Orge River catchment scale (France)

NASA Astrophysics Data System (ADS)

Botta, Fabrizio; Chevreuil, Marc; Blanchoud, Hélène

2010-05-01

The general use of pesticides in the Orge Basin, located in the southern part of the Paris suburb (France), is damaging surface water quality. Consequently, an increase in the water supply costs is registered by the water supply agencies that are situated downstream the Orge confluence with the Seine River. In this catchment, high uses of glyphosate are registered for fallow fields (upstream part) and for roadway weed control (downstream part). The proportion of glyphosate coming from these two zones was not well known, along with the double source of its metabolite AMPA originated from the degradation of some detergent phosphonates. The aim of this work was firstly to identify the potential sources of glyphosate and AMPA in urban sectors (such as sewerage system inputs) and in agricultural areas and to quantify the origins of urban pesticides pathways towards surface waters at the basin scale. The new approach of this project was to collect information at three different scales to establish a first step of modeling. At the basin scale, 1 year of surface water monitoring at the outlet of the Orge River was useful to establish the inputs towards the Seine River. At the urban catchment scale, the investigations have permitted to record glyphosate and AMPA loads transferred by storm waters and by wastewaters. Loads were estimated during and out of application calendar, in different hydrological conditions such as rainfall with high intensity or dry conditions. Impact of WWTP on surface water was also demonstrated. The third phase of this work was the interpretation of agricultural inputs from two different agricultural catchments of the Orge River. The results showed the impact of urban uses of glyphosate upon the Orge River contamination with annual loads from 100 times higher from the urban zone than from the agricultural one. Storm sewers were recognized to be the main way for glyphosate transfer towards surface waters. A budget of glyphosate and AMPA inputs and

Paleomagnetism.org - An online multi-platform and open source environment for paleomagnetic analysis.

NASA Astrophysics Data System (ADS)

Koymans, Mathijs; Langereis, Cor; Pastor-Galán, Daniel; van Hinsbergen, Douwe

2017-04-01

This contribution gives an overview of Paleomagnetism.org (Koymans et al., 2016), an online environment for paleomagnetic analysis. The application is developed in JavaScript and is fully open-sourced. It presents an interactive website in which paleomagnetic data can be interpreted, evaluated, visualized, and shared with others. The application has been available from late 2015 and since then has evolved with the addition of a magnetostratigraphic tool, additional input formats, and features that emphasize on the link between geomagnetism and tectonics. In the interpretation portal, principle component analysis (Kirschvink et al., 1981) can be applied on visualized demagnetization data (Zijderveld, 1967). Interpreted directions and great circles are combined using the iterative procedure described by (McFadden and McElhinny, 1988). The resulting directions can be further used in the statistics portal or exported as raw tabulated data and high-quality figures. The available tools in the statistics portal cover standard Fisher statistics for directional data and virtual geomagnetic poles (Fisher, 1953; Butler, 1992; Deenen et al., 2011). Other tools include the eigenvector approach foldtest (Tauxe and Watson, 1994), a bootstrapped reversal test (Tauxe et al., 2009), and the classical reversal test (McFadden and McElhinny, 1990). An implementation exists for the detection and correction of inclination shallowing in sediments (Tauxe and Kent, 2004; Tauxe et al., 2008), and a module to visualize apparent polar wander paths (Torsvik et al., 2012; Kent and Irving, 2010; Besse and Courtillot, 2002) for large continent-bearing plates. A miscellaneous portal exists for a set of tools that include a boostrapped oroclinal test (Pastor-Galán et al., 2016) for assessing possible linear relationships between strike and declination. Another tool that is available completes a net tectonic rotation analysis (after Morris et al., 1999) that restores a dyke to its paleo-vertical and

The selective glycine uptake inhibitor org 25935 as an adjunctive treatment to atypical antipsychotics in predominant persistent negative symptoms of schizophrenia: results from the GIANT trial.

PubMed

Schoemaker, Joep H; Jansen, Wim T; Schipper, Jacques; Szegedi, Armin

2014-04-01

Using a selective glycine uptake inhibitor as adjunctive to second-generation antipsychotic (SGA) was hypothesized to ameliorate negative and/or cognitive symptoms in subjects with schizophrenia. Subjects with predominant persistent negative symptoms (previously stabilized ≥3 months on an SGA) were enrolled in a randomized, placebo-controlled trial to investigate adjunctive treatment with Org 25935, a selective inhibitor of type 1 glycine transporter, over 12 weeks in a flexible dose design. Org 25935 was tested at 4 to 8 mg twice daily and 12 to 16 mg twice daily versus placebo. Primary efficacy outcome was mean change from baseline in Scale for Assessment of Negative Symptoms composite score. Secondary efficacy end points were Positive and Negative Syndrome Scale total and subscale scores, depressive symptoms (Calgary Depression Scale for Schizophrenia), global functioning (Global Assessment of Functioning scale), and cognitive measures using a computerized battery (Central Nervous System Vital Signs). Responder rates were assessed post hoc. A total of 215 subjects were randomized, of which 187 (87%) completed the trial. Both dose groups of Org 25935 did not differ significantly from placebo on Scale for Assessment of Negative Symptoms, Positive and Negative Syndrome Scale (total or subscale scores), Global Assessment of Functioning, or the majority of tested cognitive domains. Org 25935 was generally well tolerated within the tested dose range, with no meaningful effects on extrapyramidal symptoms and some reports of reversible visual adverse effects. Org 25935 did not differ significantly from placebo in reducing negative symptoms or improving cognitive functioning when administered as adjunctive treatment to SGA. In our study population, Org 25935 appeared to be well tolerated in the tested dose ranges.

onlineDeCISion.org: a web-based decision aid for DCIS treatment.

PubMed

Ozanne, Elissa M; Schneider, Katharine H; Soeteman, Djøra; Stout, Natasha; Schrag, Deborah; Fordis, Michael; Punglia, Rinaa S

2015-11-01

Women diagnosed with DCIS face complex treatment decisions and often do so with inaccurate and incomplete understanding of the risks and benefits involved. Our objective was to create a tool to guide these decisions for both providers and patients. We developed a web-based decision aid designed to provide clinicians with tailored information about a patient’s recurrence risks and survival outcomes following different treatment strategies for DCIS. A theoretical framework, microsimulation model (Soeteman et al., J Natl Cancer 105:774–781, 2013) and best practices for web-based decision tools guided the development of the decision aid. The development process used semi-structured interviews and usability testing with key stakeholders, including a diverse group of multidisciplinary clinicians and a patient advocate. We developed onlineDeCISion.​org to include the following features that were rated as important by the stakeholders: (1) descriptions of each of the standard treatment options available; (2) visual projections of the likelihood of time-specific (10-year and lifetime) breast-preservation, recurrence, and survival outcomes; and (3) side-by-side comparisons of down-stream effects of each treatment choice. All clinicians reviewing the decision aid in usability testing were interested in using it in their clinical practice. The decision aid is available in a web-based format and is planned to be publicly available. To improve treatment decision making in patients with DCIS, we have developed a web-based decision aid onlineDeCISion.​org that conforms to best practices and that clinicians are interested in using in their clinics with patients to better inform treatment decisions.

Detection of Intermediate-Period Transiting Planets with a Network of Small Telescopes: transitsearch.org

NASA Astrophysics Data System (ADS)

Seagroves, Scott; Harker, Justin; Laughlin, Gregory; Lacy, Justin; Castellano, Tim

2003-12-01

We describe a project (transitsearch.org) currently attempting to discover transiting intermediate-period planets orbiting bright parent stars, and we simulate that project's performance. The discovery of such a transit would be an important astronomical advance, bridging the critical gap in understanding between HD 209458b and Jupiter. However, the task is made difficult by intrinsically low transit probabilities and small transit duty cycles. This project's efficient and economical strategy is to photometrically monitor stars that are known (from radial velocity surveys) to bear planets, using a network of widely spaced observers with small telescopes. These observers, each individually capable of precision (1%) differential photometry, monitor candidates during the time windows in which the radial velocity solution predicts a transit if the orbital inclination is close to 90°. We use Monte Carlo techniques to simulate the performance of this network, performing simulations with different configurations of observers in order to optimize coordination of an actual campaign. Our results indicate that transitsearch.org can reliably rule out or detect planetary transits within the current catalog of known planet-bearing stars. A distributed network of skilled amateur astronomers and small college observatories is a cost-effective method for discovering the small number of transiting planets with periods in the range 10 days

CredibleMeds.org: What does it offer?

PubMed

Woosley, Raymond L; Black, Kristin; Heise, C William; Romero, Klaus

2018-02-01

Since the 1990s, when numerous non-cardiac drugs were first recognized to have the potential to prolong the QT interval and cause torsades de pointes (TdP), clinicians, drug regulators, drug developers, and clinical investigators have become aware of the complexities of assessing evidence and determining TdP causality for the many drugs being marketed or under development. To facilitate better understanding, the Arizona Center for Education and Research on Therapeutics, known as AZCERT, has developed the CredibleMeds.org website which includes QTdrugs, a listing of over 220 drugs placed in four risk categories based on their association with QT prolongation and TdP. Since the site was launched in 1999, it has become the single and most reliable source of information of its kind for patients, healthcare providers, and research scientists. Over 96,000 registered users rely on the QTdrugs database as their primary resource to inform their medication use, their prescribing or their clinical research into the impact of QT-prolonging drugs and drug-induced arrhythmias. The QTdrugs lists are increasingly used as the basis for clinical decision support systems in healthcare and for metrics of prescribing quality by healthcare insurers. A free smartphone app and an application program interface enable rapid and mobile access to the lists. Also, the CredibleMeds website offers numerous educational resources for patients, educators and healthcare providers that foster the safe use of medications. Copyright © 2018 Elsevier Inc. All rights reserved.

Differential effects of the new glucocorticoid receptor antagonist ORG 34517 and RU486 (mifepristone) on glucocorticoid receptor nuclear translocation in the AtT20 cell line.

PubMed

Peeters, B W M M; Ruigt, G S F; Craighead, M; Kitchener, P

2008-12-01

Glucocorticoid agonists bind to cytoplasmic glucocorticoid receptors (GRs) and subsequently translocate as an agonist-GR complex into the nucleus. In the nucleus the complex regulates the transcription of target genes. A number of GR antagonists (RU486, progesterone, RU40555) have also been shown to induce receptor translocation. These compounds should be regarded as partial agonists. For the nonselective progesterone receptor antagonists, RTI3021-012 and RTI3021-022, it was shown that GR antagonism is possible without the induction of GR translocation. In the present studies, the new GR antagonist, ORG 34517, was investigated for its potential to induce GR translocation and to antagonize corticosterone-induced GR translocation in the AtT20 (mouse pituitary) cell line. ORG 34517 was compared to RU486. In contrast to RU486, ORG 34517 (at doses up to 3 x 10(-7) M) did not induce GR translocation, but was able to block corticosterone (3 x 10(-8) M) induced GR translocation. ORG 34517 can be regarded as a true competitive GR antagonist without partial agonistic activities.

Improving quit rates of web-delivered interventions for smoking cessation: full-scale randomized trial of WebQuit.org versus Smokefree.gov.

PubMed

Bricker, Jonathan B; Mull, Kristin E; McClure, Jennifer B; Watson, Noreen L; Heffner, Jaimee L

2018-05-01

Millions of people world-wide use websites to help them quit smoking, but effectiveness trials have an average 34% follow-up data retention rate and an average 9% quit rate. We compared the quit rates of a website using a new behavioral approach called Acceptance and Commitment Therapy (ACT; WebQuit.org) with the current standard of the National Cancer Institute's (NCI) Smokefree.gov website. A two-arm stratified double-blind individually randomized trial (n = 1319 for WebQuit; n = 1318 for Smokefree.gov) with 12-month follow-up. United States. Adults (n = 2637) who currently smoked at least five cigarettes per day were recruited from March 2014 to August 2015. At baseline, participants were mean [standard deviation (SD)] age 46.2 years (13.4), 79% women and 73% white. WebQuit.org website (experimental) provided ACT for smoking cessation; Smokefree.gov website (comparison) followed US Clinical Practice Guidelines for smoking cessation. The primary outcome was self-reported 30-day point prevalence abstinence at 12 months. The 12-month follow-up data retention rate was 88% (2309 of 2637). The 30-day point prevalence abstinence rates at the 12-month follow-up were 24% (278 of 1141) for WebQuit.org and 26% (305 of 1168) for Smokefree.gov [odds ratio (OR) = 0.91; 95% confidence interval (CI) = 0.76, 1.10; P = 0.334] in the a priori complete case analysis. Abstinence rates were 21% (278 of 1319) for WebQuit.org and 23% (305 of 1318) for Smokefree.gov (OR = 0.89 (0.74, 1.07; P = 0.200) when missing cases were imputed as smokers. The Bayes factor comparing the primary abstinence outcome was 0.17, indicating 'substantial' evidence of no difference between groups. WebQuit.org and Smokefree.gov had similar 30-day point prevalence abstinence rates at 12 months that were descriptively higher than those of prior published website-delivered interventions and telephone counselor-delivered interventions. © 2017 Society for the Study of Addiction.

Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial.

PubMed

Nations, Kari R; Dogterom, Peter; Bursi, Roberta; Schipper, Jacques; Greenwald, Scott; Zraket, David; Gertsik, Lev; Johnstone, Jack; Lee, Allen; Pande, Yogesh; Ruigt, Ge; Ereshefsky, Larry

2012-12-01

Org 26576 acts by modulating ionotropic AMPA-type glutamate receptors to enhance glutamatergic neurotransmission. The aim of this Phase 1b study (N=54) was to explore safety, tolerability, pharmacokinetics, and pharmacodynamics of Org 26576 in depressed patients. Part I (N=24) evaluated the maximum tolerated dose (MTD) and optimal titration schedule in a multiple rising dose paradigm (range 100 mg BID to 600 mg BID); Part II (N=30) utilized a parallel groups design (100 mg BID, 400 mg BID, placebo) to examine all endpoints over a 28-day dosing period. Based on the number of moderate intensity adverse events reported at the 600 mg BID dose level, the MTD established in Part I was 450 mg BID. Symptomatic improvement as measured by the Montgomery-Asberg Depression Rating Scale was numerically greater in the Org 26576 groups than in the placebo group in both study parts. In Part II, the 400 mg BID dose was associated with improvements in executive functioning and speed of processing cognitive tests. Org 26576 was also associated with growth hormone increases and cortisol decreases at the end of treatment but did not influence prolactin or brain-derived neurotrophic factor. The quantitative electroencephalogram index Antidepressant Treatment Response at Week 1 was able to significantly predict symptomatic response at endpoint in the active treatment group, as was early improvement in social acuity. Overall, Org 26576 demonstrated good tolerability and pharmacokinetic properties in depressed patients, and pharmacodynamic endpoints suggested that it may show promise in future well-controlled, adequately powered proof of concept trials.

Validity and usability of a professional association's web-based knowledge translation portal: American Physical Therapy Association's PTNow.org.

PubMed

Deutsch, Judith E; Romney, Wendy; Reynolds, Jan; Manal, Tara Jo

2015-10-08

PTNow.org is an evidence-based, on-line portal created by a professional membership association to promote use of evidence in practice and to help decrease unwarranted variation in practice. The site contains synthesis documents designed to promote efficient clinical reasoning. These documents were written and peer-reviewed by teams of content experts and master clinicians. The purpose of this paper is to report on the content and construct validity as well as usability of the site. Physical therapist participants used clinical summaries (available in 3 formats--as a full summary with hyperlinks, "quick takes" with hyperlinks, and a portable two-page version) on the PTNow.org site to answer knowledge acquisition and clinical reasoning questions related to four patient scenarios. They also responded to questions about ease of use related to website navigation and about format and completeness of information using a 1-5 Likert scale. Responses were coded to reflect how participants used the site and then were summarized descriptively. Preferences for clinical summary format were analyzed using an analysis of variance (ANOVA) and a Dunnett T3 post hoc analysis. Seventeen participants completed the study. Clinical relevance and completeness ratings by experienced clinicians, which were used as the measure of content validity, ranged from 3.1 to 4.6 on a 5 point scale. Construct validity based on the information on the PTNow.org site was supported for knowledge acquisition questions 66 % of the time and for clinical reasoning questions 40 % of the time. Usability ratings for the full clinical summary were 4.6 (1.2); for the quick takes, 3.5 (.98); and for the portable clinical summary, 4.0 (.45). Participants preferred the full clinical summary over the other two formats (F = 5.908, P = 0.007). One hundred percent of the participants stated that they would recommend the PTNow site to their colleagues. Prelimary evidence supported both content validity and

MortalityPredictors.org: a manually-curated database of published biomarkers of human all-cause mortality.

PubMed

Peto, Maximus V; De la Guardia, Carlos; Winslow, Ksenia; Ho, Andrew; Fortney, Kristen; Morgen, Eric

2017-08-31

Biomarkers of all-cause mortality are of tremendous clinical and research interest. Because of the long potential duration of prospective human lifespan studies, such biomarkers can play a key role in quantifying human aging and quickly evaluating any potential therapies. Decades of research into mortality biomarkers have resulted in numerous associations documented across hundreds of publications. Here, we present MortalityPredictors.org , a manually-curated, publicly accessible database, housing published, statistically-significant relationships between biomarkers and all-cause mortality in population-based or generally healthy samples. To gather the information for this database, we searched PubMed for appropriate research papers and then manually curated relevant data from each paper. We manually curated 1,576 biomarker associations, involving 471 distinct biomarkers. Biomarkers ranged in type from hematologic (red blood cell distribution width) to molecular (DNA methylation changes) to physical (grip strength). Via the web interface, the resulting data can be easily browsed, searched, and downloaded for further analysis. MortalityPredictors.org provides comprehensive results on published biomarkers of human all-cause mortality that can be used to compare biomarkers, facilitate meta-analysis, assist with the experimental design of aging studies, and serve as a central resource for analysis. We hope that it will facilitate future research into human mortality and aging.

MortalityPredictors.org: a manually-curated database of published biomarkers of human all-cause mortality

PubMed Central

Winslow, Ksenia; Ho, Andrew; Fortney, Kristen; Morgen, Eric

2017-01-01

Biomarkers of all-cause mortality are of tremendous clinical and research interest. Because of the long potential duration of prospective human lifespan studies, such biomarkers can play a key role in quantifying human aging and quickly evaluating any potential therapies. Decades of research into mortality biomarkers have resulted in numerous associations documented across hundreds of publications. Here, we present MortalityPredictors.org, a manually-curated, publicly accessible database, housing published, statistically-significant relationships between biomarkers and all-cause mortality in population-based or generally healthy samples. To gather the information for this database, we searched PubMed for appropriate research papers and then manually curated relevant data from each paper. We manually curated 1,576 biomarker associations, involving 471 distinct biomarkers. Biomarkers ranged in type from hematologic (red blood cell distribution width) to molecular (DNA methylation changes) to physical (grip strength). Via the web interface, the resulting data can be easily browsed, searched, and downloaded for further analysis. MortalityPredictors.org provides comprehensive results on published biomarkers of human all-cause mortality that can be used to compare biomarkers, facilitate meta-analysis, assist with the experimental design of aging studies, and serve as a central resource for analysis. We hope that it will facilitate future research into human mortality and aging. PMID:28858850

Analysis of avalanche risk factors in backcountry terrain based on usage frequency and accident data in Switzerland

NASA Astrophysics Data System (ADS)

Techel, F.; Zweifel, B.; Winkler, K.

2015-09-01

Recreational activities in snow-covered mountainous terrain in the backcountry account for the vast majority of avalanche accidents. Studies analyzing avalanche risk mostly rely on accident statistics without considering exposure (or the elements at risk), i.e., how many, when and where people are recreating, as data on recreational activity in the winter mountains are scarce. To fill this gap, we explored volunteered geographic information on two social media mountaineering websites - bergportal.ch and camptocamp.org. Based on these data, we present a spatiotemporal pattern of winter backcountry touring activity in the Swiss Alps and compare this with accident statistics. Geographically, activity was concentrated in Alpine regions relatively close to the main Swiss population centers in the west and north. In contrast, accidents occurred equally often in the less-frequented inner-alpine regions. Weekends, weather and avalanche conditions influenced the number of recreationists, while the odds to be involved in a severe avalanche accident did not depend on weekends or weather conditions. However, the likelihood of being involved in an accident increased with increasing avalanche danger level, but also with a more unfavorable snowpack containing persistent weak layers (also referred to as an old snow problem). In fact, the most critical situation for backcountry recreationists and professionals occurred on days and in regions when both the avalanche danger was critical and when the snowpack contained persistent weak layers. The frequently occurring geographical pattern of a more unfavorable snowpack structure also explains the relatively high proportion of accidents in the less-frequented inner-alpine regions. These results have practical implications: avalanche forecasters should clearly communicate the avalanche danger and the avalanche problem to the backcountry user, particularly if persistent weak layers are of concern. Professionals and recreationists, on the

Orthochina.org: case-based orthopaedic Wiki project in China.

PubMed

Ma, Zhen-Sheng; Zhang, Hong-Ju; Yu, Tao; Ren, Gang; Du, Guo-Sheng; Wang, Yong-Hua

2008-10-01

Traditional continuing medical education (CME) depended primarily on periodic courses and conferences. The cost-effectiveness of these courses has not been established, and often the content is not tailored to best meet the needs of the students. Internet training has the potential to accomplish these goals. Over the last 10 years, we have developed a Web site entitled "Orthochina.org," based upon the wiki concept, which uses an interactive, case-based format. We describe the development of online case discussions, and various technical and administrative requirements. As of December 31, 2007, there were 33,984 registered users, 9,759 of which passed the confirmation procedures. In 2007, an average of 211 registrants visited daily. The average number of first page clicks was 4,248 per day, and the average number of posts was 70 per day. All cases submitted for discussion include the patient's complaint, physical examination findings, and relevant images based on specific criteria for case discussion. The case discussions develop well professionally. No spam posting or unauthorized personal advertisement is permitted. In conclusion, online academic discussions proceed well when the orthopaedic surgeons who participate have established their identities.

Evaluation of the glycine transporter inhibitor Org 25935 as augmentation to cognitive-behavioral therapy for panic disorder: a multicenter, randomized, double-blind, placebo-controlled trial.

PubMed

Nations, Kari R; Smits, Jasper A J; Tolin, David F; Rothbaum, Barbara O; Hofmann, Stefan G; Tart, Candyce D; Lee, Allen; Schipper, Jacques; Sjogren, Magnus; Xue, Dixi; Szegedi, Armin; Otto, Michael W

2012-05-01

A growing body of evidence supports the efficacy of D-cycloserine (DCS), a partial agonist at the N-methyl-D-aspartate (NMDA) glutamate receptor, as augmentation to cognitive-behavioral therapy (CBT) in the treatment of anxiety disorders. Org 25935 is a glycine transporter 1 inhibitor that acts to increase synaptic glycine levels and enhance NMDA-mediated glutamatergic activity. The aim of this study was to examine the efficacy of a glutamatergic compound other than DCS in a CBT augmentation paradigm. This was a randomized, double-blind, placebo-controlled, parallel-group clinical trial for which participants were recruited from November 2008 through February 2010. Eligible adult patients diagnosed (DSM-IV) with panic disorder with or without agoraphobia (N = 40) were scheduled to receive 5 manualized CBT treatment sessions. Participants were randomly assigned to receive either a dose of Org 25935 (4 mg or 12 mg) or placebo 2 hours prior to the start of CBT sessions 3, 4, and 5. The primary endpoint was symptomatic change as measured by the Panic Disorder Severity Scale (PDSS) 1 week following the last CBT session. Although mean PDSS total scores decreased significantly from baseline to end of treatment in every group, no statistically significant benefit was observed for Org 25935 (4 or 12 mg) over placebo on the primary endpoint or on any secondary efficacy endpoint. Org 25935 showed no safety issues at either dose but was much better tolerated at the 4-mg dose level than at the 12-mg dose level. Org 25935 demonstrated no benefit over placebo in augmenting CBT for panic disorder. Study limitations and implications are discussed. clinicaltrials.gov Identifier: NCT00725725. © Copyright 2012 Physicians Postgraduate Press, Inc.

Health information for young people where and when they most want it: a case study of www.teenagehealthfreak.org.

PubMed

McPherson, Ann; Macfarlane, Aidan

2007-08-01

The Internet is an exciting resource for providing immediately available, evidence-based, health information for young people in an age-appropriate form on a 24 hours/day, 7 days/week basis. www.teenagehealthfreak.org is a United Kingdom-based Web site designed to take advantage of this. The content of the site, which is the leading teenage health Web site on a Google search, contains both the diary of a hypochondriac 15-year-old boy and a virtual doctor's surgery. It also allows for young people to e-mail health-related questions and receive relevant answers from a health expert. Analysis of the content of these e-mails indicates the unmet health needs and concerns of young people. Future developments of the site include linking the site www.youthhealthtalk.org, a Web site that contains videotaped interviews with young people who have a variety other health concerns.

The Common Core State Standards and the Role of Instructional Materials: A Case Study on EdReports.org

ERIC Educational Resources Information Center

Watt, Michael G.

2016-01-01

The purpose of this study was to review research studies investigating the role of instructional materials in relation to the Common Core State Standards and to evaluate whether a new organisation, EdReports.org, founded to evaluate the alignment of instructional materials to the Common Core State Standards, has achieved its objectives. Content…

Supplemental surveillance: a review of 2015 and 2016 agricultural injury data from news reports on AgInjuryNews.org.

PubMed

Weichelt, Bryan; Gorucu, Serap

2018-01-31

Agriculture, forestry, fishing and hunting industry is the most hazardous occupational sector in the USA. Even with this level of occupational risk, several national and state-level occupational injury surveillance programmes have been eliminated, leaving regional efforts to analyse multiple sources and compile data on agricultural injuries and fatalities. No up-to-date centralised national database for agricultural injuries/fatalities in the USA currently exists. Using the public data on AgInjuryNews.org, this study considered a wide range of variables to examine fatalities and injuries of the industry in 2015 and 2016. The results reported in this paper sought to explore and understand common data elements of US news reports. As of 5 April 2017, more than 3000 articles across 36 years were contained in the dataset. We selected 2 years to review, 2015 and 2016, which represented the most complete years to date; 2015 was the first year in which systematic collection was initiated by the AgInjuryNews.org team. Data were coded based on the Occupational Injury and Illness Classification System source and event/exposure types. A total of 1345 victims were involved in 1044 incidents. Leading sources of injuries were vehicles and machinery, and the most common event/exposure type was transportation. This study demonstrated that data from AgInjuryNew.org is consistent with previous literature, and it can supply up-to-date data as an open-source surveillance supplement, disseminated for health and safety stakeholders. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Growth inhibition induced by antiprogestins RU-38486, ORG-31710, and CDB-2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2.

PubMed

Goyeneche, Alicia A; Seidel, Erin E; Telleria, Carlos M

2012-06-01

Antiprogestins have been largely utilized in reproductive medicine, yet their repositioning for oncologic use is rapidly emerging. In this study we investigated the molecular mediators of the anti-ovarian cancer activity of the structurally related antiprogestins RU-38486, ORG-31710 and CDB-2914. We studied the responses of wt p53 OV2008 and p53 null SK-OV-3 cells to varying doses of RU-38486, ORG-31710 and CDB-2914. The steroids inhibited the growth of both cell lines with a potency of RU-38486 > ORG-31710 > CDB-2914, and were cytostatic at lower doses but lethal at higher concentrations. Antiprogestin-induced lethality associated with morphological features of apoptosis, hypodiploid DNA content, DNA fragmentation, and cleavage of executer caspase substrate PARP. Cell death ensued despite RU-38486 caused transient up-regulation of anti-apoptotic Bcl-2, ORG-31710 induced transient up-regulation of inhibitor of apoptosis XIAP, and CDB-2914 up-regulated both XIAP and Bcl-2. The antiprogestins induced accumulation of Cdk inhibitors p21(cip1) and p27(kip1) and increased association of p21(cip1) and p27(kip1) with Cdk-2. They also promoted nuclear localization of p21(cip1) and p27(kip1), reduced the nuclear abundances of Cdk-2 and cyclin E, and blocked the activity of Cdk-2 in both nucleus and cytoplasm. The cytotoxic potency of the antiprogestins correlated with the magnitude of the inhibition of Cdk-2 activity, ranging from G1 cell cycle arrest towards cell death. Our results suggest that, as a consequence of their cytostatic and lethal effects, antiprogestin steroids of well-known contraceptive properties emerge as attractive new agents to be repositioned for ovarian cancer therapeutics.

Legume Information System (LegumeInfo.org): a key component of a set of federated data resources for the legume family

USDA-ARS?s Scientific Manuscript database

The Legume Information System (LIS), at http://legumeinfo.org, is a genomic data portal (GDP) for the legume family. LIS provides access to genetic and genomic information for major crop and model legumes. With more than two-dozen domesticated legume species, there are numerous specialists working o...

Temporal alteration of spreading depression by the glycine transporter type-1 inhibitors NFPS and Org-24461 in chicken retina.

PubMed

Kertesz, Szabolcs; Szabo, Geza; Udvari, Szabolcs; Levay, Gyorgy; Matyus, Peter; Harsing, Laszlo G

2013-01-25

We used isolated chicken retina to induce spreading depression by the glutamate receptor agonist N-methyl-d-aspartate. The N-methyl-d-aspartate-induced latency time of spreading depression was extended by the glycine(B) binding site competitive antagonist 7-chlorokynurenic acid. Addition of the glycine transporter type-1 inhibitors NFPS and Org-24461 reversed the inhibitory effect of 7-chlorokynurenic acid on N-methyl-d-aspartate-evoked spreading depression. The glycine uptake inhibitory activity of Org-24461, NFPS, and some newly synthesized analogs of NFPS was determined in CHO cells stably expressing human glycine transporter type-1b isoform. Compounds, which failed to inhibit glycine transporter type-1, also did not have effect on retinal spreading depression. These experiments indicate that the spreading depression model in chicken retina is a useful in vitro test to determine activity of glycine transporter type-1 inhibitors. In addition, our data serve further evidence for the role of glycine transporter type-1 in retinal neurotransmission and light processing. Copyright © 2012 Elsevier B.V. All rights reserved.

minepath.org: a free interactive pathway analysis web server.

PubMed

Koumakis, Lefteris; Roussos, Panos; Potamias, George

2017-07-03

( www.minepath.org ) is a web-based platform that elaborates on, and radically extends the identification of differentially expressed sub-paths in molecular pathways. Besides the network topology, the underlying MinePath algorithmic processes exploit exact gene-gene molecular relationships (e.g. activation, inhibition) and are able to identify differentially expressed pathway parts. Each pathway is decomposed into all its constituent sub-paths, which in turn are matched with corresponding gene expression profiles. The highly ranked, and phenotype inclined sub-paths are kept. Apart from the pathway analysis algorithm, the fundamental innovation of the MinePath web-server concerns its advanced visualization and interactive capabilities. To our knowledge, this is the first pathway analysis server that introduces and offers visualization of the underlying and active pathway regulatory mechanisms instead of genes. Other features include live interaction, immediate visualization of functional sub-paths per phenotype and dynamic linked annotations for the engaged genes and molecular relations. The user can download not only the results but also the corresponding web viewer framework of the performed analysis. This feature provides the flexibility to immediately publish results without publishing source/expression data, and get all the functionality of a web based pathway analysis viewer. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

The influence of question design on the response to self-assessment in www.elearnSCI.org: a submodule pilot study.

PubMed

Liu, N; Li, X-W; Zhou, M-W; Biering-Sørensen, F

2015-08-01

This is an interventional training session. The objective of this study was to investigate the difference in response to self-assessment questions in the original and an adjusted version for a submodule of www.elearnSCI.org for student nurses. The study was conducted in a teaching hospital affiliated to Peking University, China. In all, 28 student nurses divided into two groups (groups A and B; 14 in each) received a print-out of a Chinese translation of the slides from the 'Maintaining skin integrity following spinal cord injury' submodule in www.elearnSCI.org for self-study. Both groups were then tested using the 10 self-assessment multiple-choice questions (MCQs) related to the same submodule. Group A used the original questions, whereas group B received an adjusted questionnaire. The responses to four conventional single-answer MCQs were nearly all correct in both groups. However, in three questions, group A, with the option 'All of the above', had a higher number of correct answers than group B, with multiple-answer MCQs. In addition, in another three questions, group A, using the original multiple-answer MCQs, had fewer correct answers than group B, where it was only necessary to tick a single incorrect answer. Variations in design influence the response to questions. The use of conventional single-answer MCQs should be reconsidered, as they only examine the recall of isolated knowledge facts. The 'All of the above' option should be avoided because it would increase the number of correct answers arrived at by guessing. When using multiple-answer MCQs, it is recommended that the questions asked should be in accordance with the content within the www.elearnSCI.org.

Marine Science and Education in one Word: "planeetzee.org"

NASA Astrophysics Data System (ADS)

Seys, J.; Copejans, E.; Ameije, K.

2009-04-01

It is a major challenge to bring science and technology to the public at large and more particular to young people. This is even more true for marine sciences, due to the very nature of the study field and the fact that the underwater world is difficult to experience and communicate. Therefore it is not surprising that in Europe there are only few examples of marine educational projects that try to go beyond the ‘observe and describe' approach. In 2004 SHE Consultancy, the Flanders Marine Institute VLIZ and DAB Vloot developed a first Belgian e-learning programme dedicated to oceans and seas, with the support of the Flemish government ("Action plan Science Communication"). This programme ‘Expedition Zeeleeuw' (www.expeditiezeeleeuw.be), ran from 2005 till 2007 and challenged some 3000 Flemish students of 16-18 years old all over Flanders to find creative solutions for 10 major marine issues at the Belgian coast. The class that could convince the jury to have discovered the most creative and intelligent solutions, wan a one-week scientific expedition at sea on board the vessel Zeeleeuw. As a successor to ‘Expedition Zeeleeuw', a new e-learning project on marine science was developed in 2007: ‘Planeet Zee' i.e. ‘Planet Ocean' (www.planeetzee.org; info via info@planeetzee.org + demo-site in English available at www.planetocean.eu). The new marine and coastal e-learning project is presented as a virtual sailing trip on the Atlantic Ocean. It follows the adventures of two youngsters "borrowing" the yacht of their father and getting into trouble on the open ocean. On this journey they face 21 problems (eg. out of food, drinking water or fuel, fear for whales, Bermuda triangle, tsunami's etc… ), each of them introduced by a short movie clip. When they realize they can not solve the problem, they ask for radio help and - what a surprise! - get interesting answers from the Zeeleeuw research vessel and its 21 marine scientists on board, that appears to be in the

TransNewGuinea.org: An Online Database of New Guinea Languages.

PubMed

Greenhill, Simon J

2015-01-01

The island of New Guinea has the world's highest linguistic diversity, with more than 900 languages divided into at least 23 distinct language families. This diversity includes the world's third largest language family: Trans-New Guinea. However, the region is one of the world's least well studied, and primary data is scattered across a wide range of publications and more often then not hidden in unpublished "gray" literature. The lack of primary research data on the New Guinea languages has been a major impediment to our understanding of these languages, and the history of the peoples in New Guinea. TransNewGuinea.org aims to collect data about these languages and place them online in a consistent format. This database will enable future research into the New Guinea languages with both traditional comparative linguistic methods and novel cutting-edge computational techniques. The long-term aim is to shed light into the prehistory of the peoples of New Guinea, and to understand why there is such major diversity in their languages.

TransNewGuinea.org: An Online Database of New Guinea Languages

PubMed Central

Greenhill, Simon J.

2015-01-01

The island of New Guinea has the world’s highest linguistic diversity, with more than 900 languages divided into at least 23 distinct language families. This diversity includes the world’s third largest language family: Trans-New Guinea. However, the region is one of the world’s least well studied, and primary data is scattered across a wide range of publications and more often then not hidden in unpublished “gray” literature. The lack of primary research data on the New Guinea languages has been a major impediment to our understanding of these languages, and the history of the peoples in New Guinea. TransNewGuinea.org aims to collect data about these languages and place them online in a consistent format. This database will enable future research into the New Guinea languages with both traditional comparative linguistic methods and novel cutting-edge computational techniques. The long-term aim is to shed light into the prehistory of the peoples of New Guinea, and to understand why there is such major diversity in their languages. PMID:26506615

oldWeather.org: Citizen Science for Climate Reconstruction

NASA Astrophysics Data System (ADS)

Brohan, P.

2012-12-01

Most of us care about today's weather, and the predictions for tomorrow's; but the weather of decades and centuries ago has traditionally been of interest only to a handful of historians and climatologists. However, the increasing concern about the consequences of climate change is raising the profile of historical climatology - a good understanding of past climate is needed to judge whether today's storms and droughts are unusual, and to add confidence and context to predictions of future change. `Old weather' is changing from an academic speciality into an area of public interest, and reconstructions of past climate are being subjected to intense critical inspection. This increased public interest is a challenge for scientists, as they have to communicate their methods and results to a much wider audience; but also an opportunity, as the public can actively help with scientific projects. The oldWeather project (http://oldweather.org) takes advantage of this interest by engaging a large community of interested volunteers, who are recovering the millions of archived historic weather observations needed to reconstruct the past weather and climate. Over the past 18 months, more than 12,000 volunteers have been reading the logbooks of 300 Royal Navy ships from the period 1914-22, and transcribing the frequent and regular weather observations they contain. The wide area of operation of the Royal Navy means that the observations recovered improve historical weather reconstructions over a large fraction of the world. As well as the new climate records, the project has produced a wealth of historical information for the Navy of the period, and an active community of volunteer researchers. The project is now being extended to look at US records - from the Navy and revenue service.

The ERESE Project: Interfacing with the ERDA Digital Archive and ERR Reference Database in EarthRef.org

NASA Astrophysics Data System (ADS)

Koppers, A. A.; Staudigel, H.; Mills, H.; Keller, M.; Wallace, A.; Bachman, N.; Helly, J.; Helly, M.; Miller, S. P.; Massell Symons, C.

2004-12-01

To bridge the gap between Earth science teachers, librarians, scientists and data archive managers, we have started the ERESE project that will create, archive and make available "Enduring Resources in Earth Science Education" through information technology (IT) portals. In the first phase of this National Science Digital Library (NSDL) project, we are focusing on the development of these ERESE resources for middle and high school teachers to be used in lesson plans with "plate tectonics" and "magnetics" as their main theme. In this presentation, we will show how these new ERESE resources are being generated, how they can be uploaded via online web wizards, how they are archived, how we make them available via the EarthRef.org Digital Archive (ERDA) and Reference Database (ERR), and how they relate to the SIOExplorer database containing data objects for all seagoing cruises carried out by the Scripps Institution of Oceanography. The EarthRef.org web resource uses the vision of a "general description" of the Earth as a geological system to provide an IT infrastructure for the Earth sciences. This emphasizes the marriage of the "scientific process" (and its results) with an educational cyber-infrastructure for teaching Earth sciences, on any level, from middle school to college and graduate levels. Eight different databases reside under EarthRef.org from which ERDA holds any digital object that has been uploaded by other scientists, teachers and students for free, while the ERR holds more than 80,000 publications. For more than 1,500 of these publications, this latter database makes available for downloading JPG/PDF images of the abstracts, data tables, methods and appendices, together with their digitized contents in Microsoft Word and Excel format. Both holdings are being used to store the ERESE objects that are being generated by a group of undergraduate students majoring in Environmental Systems (ESYS) program at the UCSD with an emphasis on the Earth Sciences

A critical review of the readability of online patient education resources from RadiologyInfo.Org.

PubMed

Hansberry, David R; John, Ann; John, Elizabeth; Agarwal, Nitin; Gonzales, Sharon F; Baker, Stephen R

2014-03-01

Health consumers and their families rely on the Internet as a source of authoritative information regarding the procedures used to reach a diagnosis, effect treatment, and influence prognosis. In radiology, online materials can be a means by which to offer patients comprehensible explanations of the capabilities, the risks and rewards, and the techniques under our purview. Consequently, estimations of health literacy should take into account the reading level of the average American when composing and transmitting such information to the lay public without the mediation of a referring physician. In December 2012, patient education reports from the files of RadiologyInfo.org, a jointly sponsored website of the American College of Radiology and the Radiological Society of North America, were downloaded to assess their textual sophistication. All 138 patient education articles including the glossary were analyzed for their respective level of "readability" using the following 10 evaluative scales: Flesch Reading Ease, Flesch-Kincaid Grade Level, Simple Measure of Gobbledygook Grading, Coleman-Liau Index, Gunning Fog Index, New Dale-Chall scale, FORCAST, Fry graph, Raygor Readability Estimate, and New Fog Count. The 138 online patient education articles were written, on average, between the 10th and 14th grade levels, which exceeds both the American Medical Association and the National Institutes of Health recommendations that patient education resources be comprehensible to those who read no higher than the seventh grade level. Patients may accrue a greater benefit from written articles available on RadiologyInfo.org if the texts were revised to be in compliance with the National Institutes of Health and American Medical Association grade level recommendations. This could lead to a broadened appreciation of the capabilities of radiology's role in general and enhanced understanding of imaging techniques and their application to clinical practice.

The Schema.org Datasets Schema: Experiences at the National Snow and Ice Data Center

NASA Astrophysics Data System (ADS)

Duerr, R.; Billingsley, B. W.; Harper, D.; Kovarik, J.

2014-12-01

Data discovery, is still a major challenge for many users. Relevant data may be located anywhere. There are currently no existing universal data registries. Often users start with a simple query through their web browser. But how do you get your data to actually show up near the top of the results? One relatively new way to accomplish this is to use schema.org dataset markup in your data pages. Theoretically this provides web crawlers the additional information needed so that a query for data will preferentially return those pages that were marked up accordingly. The National Snow and Ice Data Center recently implemented an initial set of markup in the data set pages returned by its catalog. The Datasets data model, our process, challenges encountered and results will be described.

Comparing three cohorts of MSM sampled via sex parties, bars/clubs, and Craigslist.org: implications for researchers and providers.

PubMed

Grov, Christian; Rendina, H Jonathon; Parsons, Jeffrey T

2014-08-01

With limited exceptions, few studies have systematically reported on psychosocial and demographic characteristic differences in samples of men who have sex with men (MSM) based on where they were recruited. This study compared three sexually active cohorts of MSM recruited via Craigslist.org (recruited via modified time-space sampling), gay bars and clubs (recruited via time-space sampling), and private sex parties (identified via passive recruitment and listserves), finding mixed results with regard to differences in demographic characteristics, STI history, and psychosocial measures. Men recruited from sex parties were significantly older, reported more symptoms of sexual compulsivity, more likely to be HIV-positive, more likely to report a history of STIs, and more likely to self-identify as a barebacker, than men recruited from the other two venues. In contrast, men from Craigslist.org reported the lowest levels of attachment to the gay and bisexual community and were the least likely to self-identify as gay. Men from bars and clubs were significantly younger, and were more likely to report use of hallucinogens and crack or cocaine. Our findings highlight that the venues in which MSM are recruited have meaningful consequences in terms of the types of individuals who are reached.

Alterations in brain extracellular dopamine and glycine levels following combined administration of the glycine transporter type-1 inhibitor Org-24461 and risperidone.

PubMed

Nagy, Katalin; Marko, Bernadett; Zsilla, Gabriella; Matyus, Peter; Pallagi, Katalin; Szabo, Geza; Juranyi, Zsolt; Barkoczy, Jozsef; Levay, Gyorgy; Harsing, Laszlo G

2010-12-01

The most dominant hypotheses for the pathogenesis of schizophrenia have focused primarily upon hyperfunctional dopaminergic and hypofunctional glutamatergic neurotransmission in the central nervous system. The therapeutic efficacy of all atypical antipsychotics is explained in part by antagonism of the dopaminergic neurotransmission, mainly by blockade of D(2) dopamine receptors. N-methyl-D-aspartate (NMDA) receptor hypofunction in schizophrenia can be reversed by glycine transporter type-1 (GlyT-1) inhibitors, which regulate glycine concentrations at the vicinity of NMDA receptors. Combined drug administration with D(2) dopamine receptor blockade and activation of hypofunctional NMDA receptors may be needed for a more effective treatment of positive and negative symptoms and the accompanied cognitive deficit in schizophrenia. To investigate this type of combined drug administration, rats were treated with the atypical antipsychotic risperidone together with the GlyT-1 inhibitor Org-24461. Brain microdialysis was applied in the striatum of conscious rats and determinations of extracellular dopamine, DOPAC, HVA, glycine, glutamate, and serine concentrations were carried out using HPLC/electrochemistry. Risperidone increased extracellular concentrations of dopamine but failed to influence those of glycine or glutamate measured in microdialysis samples. Org-24461 injection reduced extracellular dopamine concentrations and elevated extracellular glycine levels but the concentrations of serine and glutamate were not changed. When risperidone and Org-24461 were added in combination, a decrease in extracellular dopamine concentrations was accompanied with sustained elevation of extracellular glycine levels. Interestingly, the extracellular concentrations of glutamate were also enhanced. Our data indicate that coadministration of an antipsychotic with a GlyT-1 inhibitor may normalize hypofunctional NMDA receptor-mediated glutamatergic neurotransmission with reduced

Enterprise tools to promote interoperability: MonitoringResources.org supports design and documentation of large-scale, long-term monitoringprograms

NASA Astrophysics Data System (ADS)

Weltzin, J. F.; Scully, R. A.; Bayer, J.

2016-12-01

Individual natural resource monitoring programs have evolved in response to different organizational mandates, jurisdictional needs, issues and questions. We are establishing a collaborative forum for large-scale, long-term monitoring programs to identify opportunities where collaboration could yield efficiency in monitoring design, implementation, analyses, and data sharing. We anticipate these monitoring programs will have similar requirements - e.g. survey design, standardization of protocols and methods, information management and delivery - that could be met by enterprise tools to promote sustainability, efficiency and interoperability of information across geopolitical boundaries or organizational cultures. MonitoringResources.org, a project of the Pacific Northwest Aquatic Monitoring Partnership, provides an on-line suite of enterprise tools focused on aquatic systems in the Pacific Northwest Region of the United States. We will leverage on and expand this existing capacity to support continental-scale monitoring of both aquatic and terrestrial systems. The current stakeholder group is focused on programs led by bureaus with the Department of Interior, but the tools will be readily and freely available to a broad variety of other stakeholders. Here, we report the results of two initial stakeholder workshops focused on (1) establishing a collaborative forum of large scale monitoring programs, (2) identifying and prioritizing shared needs, (3) evaluating existing enterprise resources, (4) defining priorities for development of enhanced capacity for MonitoringResources.org, and (5) identifying a small number of pilot projects that can be used to define and test development requirements for specific monitoring programs.

PolarPortal.org Communicates Real-Time Developments in the Arctic

NASA Astrophysics Data System (ADS)

Langen, P. L.; Andersen, S. B.; Andersen, K. K.; Andersen, M. L.; Ahlstrom, A. P.; van As, D.; Barletta, V. R.; Box, J. E.; Citterio, M.; Colgan, W. T.; Dybkjær, G.; Forsberg, R.; Høyer, J. L.; Jensen, M. B.; Kliem, N.; Mottram, R.; Nielsen, K. P.; Olesen, M.; Quaglia, F. C.; Rasmussen, T. A.; Rodehacke, C. B.; Stendel, M.; Sandberg Sørensen, L.; Tonboe, R. T.

2014-12-01

PolarPortal.org was launched in June 2013 by a consortium of Danish institutions, including the Danish Meteorological Institute (DMI), the Geological Survey of Denmark and Greenland (GEUS) and the National Space Institute at the Technical University of Denmark (DTU-Space). Polar Portal is a single web portal presenting a wide range of near real-time information on both the Greenland ice sheet and Arctic sea-ice in a format geared for non-specialists. Polar Portal aims to meet widespread public interest in a diverse range of climate-cryosphere processes in the Arctic: What is the present Greenland ice sheet contribution to sea level rise? How quickly are outlet glaciers retreating or advancing right now? How extensive is Arctic sea-ice or how warm is the Arctic Ocean at this moment? Although public interest in such topics is widely acknowledged, an important primary task for the scientists behind Polar Portal was collaborating with media specialists to establish the knowledge range of the general public on these topics, in order for Polar Portal to appropriately present useful climate-cryosphere information. Consequently, Polar Portal is designed in a highly visual exploratory format, where individual data products are accompanied by plain written summaries, with hyperlinks to relevant journal papers for more scrutinizing users. Numerous satellite and in situ observations, together with model output, are channeled daily into the Greenland ice sheet and Arctic sea-ice divisions of Polar Portal.

Science blogging: RealClimate.org and the Global Warming debate

NASA Astrophysics Data System (ADS)

Schmidt, G. A.

2006-12-01

The media and public policy debate suffer from an extreme form of Attention Deficit Disorder. Compared to the daily news cycle, the progress of scientific debate within the peer-reviewed literature is extremely slow. This puts serious scientists who work in relatively politicised fields (global warming, evolution, stem cell research and the like) at a huge disadvantage when it comes to having their voices heard above the noise. Since Dec 2004, RealClimate.org has been operating as a group blog (a web-based journal) run by climate scientists for interested members of the public and the media. The aim has been to provide the context for climate-related news stories that is often missing in the mainstream media and to explain the basics of our field to the often confused, but curious, members of the public. In particular, it has provided rapid reaction to mis-uses and abuses of scientific results by policy advocates across the spectrum. Reactions to the blog have been overwhelmingly (but not uniformly) positive from both professionals in the media, the scientific community and the public. It has been described as the 'go-to site' for climate science in the New York Times, and received a Scientific American Science and Technology Web award in 2005. I will discuss what impacts RealClimate may have had and the pluses and minuses of trying to reach the public through this kind of outlet.

Moléculas orgánicas obtenidas en simulaciones experimentales del medio interestelar.

NASA Astrophysics Data System (ADS)

Muñoz-Caro, Guillermo Manuel

Las nubes moleculares son regiones de formación de estrellas, con temperaturas cinéticas entre 10-50 K y densidades de 103-106 átomos cm-3. Su materia está formada por gas y polvo interestelar. Estas partículas de polvo están cubiertas por una fina capa de hielo, de unos 0.01 μm, que contiene H2O y a menudo CO, CO2, CH3OH y NH3. El hielo es presumiblemente irradiado por fotones ultravioleta y rayos cósmicos en las zonas poco profundas de las nubes moleculares y las regiones circunestelares. En un sistema de vacío, P ˜ 10-7 mbar, simulamos la deposición de hielo a partir de 10 K y la irradiación ultravioleta por medio de una lámpara de descarga de hidrógeno activada con microondas. La evolución del hielo se observa por medio de un espectrómetro infrarrojo. De este modo es posible determinar la composición del hielo observado en el medio interestelar y predecir la presencia de moléculas aún no detectadas en el espacio, que han sido producto del procesamiento del hielo en nuestros experimentos. También es posible calentar el sistema hasta temperatura ambiente para sublimar el hielo depositado. Cuando el hielo ha sido previamente irradiado, se observa un residuo compuesto por moléculas orgánicas complejas, algunas prebióticas, como varios ácidos carboxílicos, aminas, amidas, ésteres y en menor proporción moléculas heterocíclicas y aminoácidos. Algunas de estas moléculas podrían detectarse en estado gaseoso por medio de observaciones milimétricas y de radio. También podrían estar presentes en el polvo cometario, cuyo análisis químico está planeado por las misiones Stardust y Rosetta. Mientras tanto, nuestro grupo está llevando a cabo el análisis de partículas de polvo interplanetario (IDPs), algunas de las cuales pueden ser de origen cometario. Al igual que ocurre con los productos obtenidos por irradiación del hielo en nuestros experimentos, algunas IDPs son ricas en material orgánico que contiene oxígeno.

Zinc speciation in the suspended particulate matter of an urban river (Orge, France): influence of seasonality and urbanization gradient.

PubMed

Le Pape, Pierre; Quantin, Cécile; Morin, Guillaume; Jouvin, Delphine; Kieffer, Isabelle; Proux, Olivier; Ghanbaja, Jaafar; Ayrault, Sophie

2014-10-21

Among trace metal pollutants, zinc is the major one in the rivers from the Paris urban area, such as the Orge River, where Zn concentration in the suspended particulate matter (SPM) can reach 2000 mg/kg in the most urbanized areas. In order to better understand Zn cycling in such urban rivers, we have determined Zn speciation in SPM as a function of both the seasonal water flow variations and the urbanization gradient along the Orge River. Using TEM/SEM-EDX and linear combination fitting (LCF) of EXAFS data at the Zn K-edge, we show that Zn mainly occurs as tetrahedrally coordinated Zn(2+) sorbed to ferrihydrite (37-46%), calcite (0-37%), amorphous SiO2 (0-21%), and organic-P (0-30%) and as octahedrally coordinated Zn(2+) in the octahedral layer of phyllosilicates (18-25%). Moreover, the Zn speciation pattern depends on the river flow rate. At low water flow, Zn speciation changes along the urbanization gradient: geogenic forms of Zn inherited from soil erosion decrease relative to Zn bound to organic-phosphates and amorphous SiO2. At high water flow, Zn speciation is dominated by soil-borne forms of Zn regardless the degree of urbanization, indicating that erosion of Zn-bearing minerals dominates the Zn contribution to SPM under such conditions.

The braingraph.org database of high resolution structural connectomes and the brain graph tools.

PubMed

Kerepesi, Csaba; Szalkai, Balázs; Varga, Bálint; Grolmusz, Vince

2017-10-01

Based on the data of the NIH-funded Human Connectome Project, we have computed structural connectomes of 426 human subjects in five different resolutions of 83, 129, 234, 463 and 1015 nodes and several edge weights. The graphs are given in anatomically annotated GraphML format that facilitates better further processing and visualization. For 96 subjects, the anatomically classified sub-graphs can also be accessed, formed from the vertices corresponding to distinct lobes or even smaller regions of interests of the brain. For example, one can easily download and study the connectomes, restricted to the frontal lobes or just to the left precuneus of 96 subjects using the data. Partially directed connectomes of 423 subjects are also available for download. We also present a GitHub-deposited set of tools, called the Brain Graph Tools, for several processing tasks of the connectomes on the site http://braingraph.org.

Spatial variability in photosynthetic and heterotrophic activity drives localized δ13C org fluctuations and carbonate precipitation in hypersaline microbial mats.

PubMed

Houghton, J; Fike, D; Druschel, G; Orphan, V; Hoehler, T M; Des Marais, D J

2014-11-01

Modern laminated photosynthetic microbial mats are ideal environments to study how microbial activity creates and modifies carbon and sulfur isotopic signatures prior to lithification. Laminated microbial mats from a hypersaline lagoon (Guerrero Negro, Baja California, Mexico) maintained in a flume in a greenhouse at NASA Ames Research Center were sampled for δ(13) C of organic material and carbonate to assess the impact of carbon fixation (e.g., photosynthesis) and decomposition (e.g., bacterial respiration) on δ(13) C signatures. In the photic zone, the δ(13) C org signature records a complex relationship between the activities of cyanobacteria under variable conditions of CO2 limitation with a significant contribution from green sulfur bacteria using the reductive TCA cycle for carbon fixation. Carbonate is present in some layers of the mat, associated with high concentrations of bacteriochlorophyll e (characteristic of green sulfur bacteria) and exhibits δ(13) C signatures similar to DIC in the overlying water column (-2.0‰), with small but variable decreases consistent with localized heterotrophic activity from sulfate-reducing bacteria (SRB). Model results indicate respiration rates in the upper 12 mm of the mat alter in situ pH and HCO3- concentrations to create both phototrophic CO2 limitation and carbonate supersaturation, leading to local precipitation of carbonate minerals. The measured activity of SRB with depth suggests they variably contribute to decomposition in the mat dependent on organic substrate concentrations. Millimeter-scale variability in the δ(13) C org signature beneath the photic zone in the mat is a result of shifting dominance between cyanobacteria and green sulfur bacteria with the aggregate signature overprinted by heterotrophic reworking by SRB and methanogens. These observations highlight the impact of sedimentary microbial processes on δ(13) C org signatures; these processes need to be considered when attempting to relate

NeuroLex.org: an online framework for neuroscience knowledge

PubMed Central

Larson, Stephen D.; Martone, Maryann E.

2013-01-01

The ability to transmit, organize, and query information digitally has brought with it the challenge of how to best use this power to facilitate scientific inquiry. Today, few information systems are able to provide detailed answers to complex questions about neuroscience that account for multiple spatial scales, and which cross the boundaries of diverse parts of the nervous system such as molecules, cellular parts, cells, circuits, systems and tissues. As a result, investigators still primarily seek answers to their questions in an increasingly densely populated collection of articles in the literature, each of which must be digested individually. If it were easier to search a knowledge base that was structured to answer neuroscience questions, such a system would enable questions to be answered in seconds that would otherwise require hours of literature review. In this article, we describe NeuroLex.org, a wiki-based website and knowledge management system. Its goal is to bring neurobiological knowledge into a framework that allows neuroscientists to review the concepts of neuroscience, with an emphasis on multiscale descriptions of the parts of nervous systems, aggregate their understanding with that of other scientists, link them to data sources and descriptions of important concepts in neuroscience, and expose parts that are still controversial or missing. To date, the site is tracking ~25,000 unique neuroanatomical parts and concepts in neurobiology spanning experimental techniques, behavioral paradigms, anatomical nomenclature, genes, proteins and molecules. Here we show how the structuring of information about these anatomical parts in the nervous system can be reused to answer multiple neuroscience questions, such as displaying all known GABAergic neurons aggregated in NeuroLex or displaying all brain regions that are known within NeuroLex to send axons into the cerebellar cortex. PMID:24009581

Effectiveness of a Multifaceted Community-Based Promotion Strategy on Use of GetHealthyHarlem.org, a Local Community Health Education Website.

PubMed

Smith, Michelle; Mateo, Katrina F; Morita, Haruka; Hutchinson, Carly; Cohall, Alwyn T

2015-07-01

The use of health communication extends beyond simply promoting or disseminating a particular product or proposed behavior change; it involves the systematic and strategic integration and execution of evidence-based, theory-driven, and community engagement strategies. Much like in public health intervention design based on health behavior theory, health communication seeks to encourage the target audience to make a positive behavior change through core concepts such as understanding and specifying the target audience, tailoring messages based on audience segmentation, and continually conducting evaluation of specific and overarching goals. While our first article "Development of a Culturally Relevant Consumer Health Information Website for Harlem, New York" focused on the design, development, and initial implementation of GetHealthyHarlem.org between 2004 and 2009, this article delves into the process of promoting the website to increase its use and then evaluating use among website visitors. Just as for the development of the website, we used community-based participatory research methods, health behavior theory, and health communication strategies to systemically develop and execute a health communication plan with the goals of increasing awareness of GetHealthyHarlem.org in Harlem, driving online traffic, and having the community recognize it as a respected community resource dedicated to improving health in Harlem. © 2015 Society for Public Health Education.

Evaluation of inSPOTLA.org: an Internet partner notification service.

PubMed

Plant, Aaron; Rotblatt, Harlan; Montoya, Jorge A; Rudy, Ellen T; Kerndt, Peter R

2012-05-01

This article presents an evaluation of inSPOTLA.org, a sexually transmitted disease partner notification Web site in Los Angeles County primarily targeting men who have sex with men (MSM). Since its launch in 2005, this Web site has received more than 400,000 visitors and resulted in nearly 50,000 e-mail postcards sent. However, there have been limited quantitative data concerning use of the service for actual partner notification. This study investigated awareness and use of inSPOTLA among MSM, as well as the effect of an advertising campaign. Data from 2 cross-sectional surveys using time-location samples were used for the evaluation, with a baseline survey conducted in 2007 and a follow-up conducted in 2009. The advertising campaign was implemented between the surveys in 2008. Awareness of inSPOTLA was 15.8% in the baseline survey and 14.4% in the follow-up survey, with no statistically significant difference. Reported use of inSPOTLA for partner notification was less than 2% in both surveys, again with no significant difference. In addition to the surveys, a high-volume sexual health clinic that serves the MSM population in Los Angeles collected data on reason for visit, including referrals from inSPOTLA, from all patients from 2007 through 2009. In 3 years, 2 individuals stated having received an inSPOTLA e-card as the reason for their visit. While website user statistics seemed to indicate an impressive level of use, our evaluation of inSPOTLA found very limited evidence of program effectiveness for the purpose of actual partner notification among MSM in Los Angeles County.

NREL Develops OpenEI.org, a Public Website Where Energy Data can be Generated, Shared, and Compared (Fact Sheet)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2013-12-01

The National Renewable Energy Laboratory (NREL) has developed OpenEI.org, a public, open, data-sharing platform where consumers, analysts, industry experts, and energy decision makers can go to boost their energy IQs, search for energy data, share data, and get access to energy applications. The free site blends elements of social media, linked open-data practices, and MediaWiki-based technology to build a collaborative environment for creating and sharing energy data with the world. The result is a powerful platform that is helping government and industry leaders around the world define policy options, make informed investment decisions, and create new businesses.

Legume information system (LegumeInfo.org): a key component of a set of federated data resources for the legume family.

PubMed

Dash, Sudhansu; Campbell, Jacqueline D; Cannon, Ethalinda K S; Cleary, Alan M; Huang, Wei; Kalberer, Scott R; Karingula, Vijay; Rice, Alex G; Singh, Jugpreet; Umale, Pooja E; Weeks, Nathan T; Wilkey, Andrew P; Farmer, Andrew D; Cannon, Steven B

2016-01-04

Legume Information System (LIS), at http://legumeinfo.org, is a genomic data portal (GDP) for the legume family. LIS provides access to genetic and genomic information for major crop and model legumes. With more than two-dozen domesticated legume species, there are numerous specialists working on particular species, and also numerous GDPs for these species. LIS has been redesigned in the last three years both to better integrate data sets across the crop and model legumes, and to better accommodate specialized GDPs that serve particular legume species. To integrate data sets, LIS provides genome and map viewers, holds synteny mappings among all sequenced legume species and provides a set of gene families to allow traversal among orthologous and paralogous sequences across the legumes. To better accommodate other specialized GDPs, LIS uses open-source GMOD components where possible, and advocates use of common data templates, formats, schemas and interfaces so that data collected by one legume research community are accessible across all legume GDPs, through similar interfaces and using common APIs. This federated model for the legumes is managed as part of the 'Legume Federation' project (accessible via http://legumefederation.org), which can be thought of as an umbrella project encompassing LIS and other legume GDPs. Published by Oxford University Press on behalf of Nucleic Acids Research 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Crowd-sourcing, Communicating, and Improving Auroral Science at the Speed of Social Media through Aurorasaurus.org

NASA Astrophysics Data System (ADS)

Patel, K.; MacDonald, E.; Case, N.; Hall, M.; Clayton, J.; Heavner, M.; Tapia, A.; Lalone, N.; McCloat, S.

2015-12-01

On March 17, 2015, a geomagnetic storm—the largest of the solar cycle to date— hit Earth and gave many sky watchers around the world a beautiful auroral display. People made thousands of aurora-related tweets and direct reports to Aurorasaurus.org, an interdisciplinary citizen science project that tracks auroras worldwide in real-time through social media and the project's apps and website. Through Aurorasaurus, researchers are converting these crowdsourced observations into valuable data points to help improve models of where aurora can be seen. In this presentation, we will highlight how the team communicates with the public during these global, sporadic events to help drive and retain participation for Aurorasaurus. We will highlight some of the co-produced scientific results and increased media interest following this event. Aurorasaurus uses mobile apps, blogging, and a volunteer scientist network to reach out to aurora enthusiasts to engage in the project. Real-time tweets are voted on by other users to verify their accuracy and are pinned on a map located on aurorasaurus.org to help show the instantaneous, global auroral visibility. Since the project launched in October 2014, hundreds of users have documented the two largest geomagnetic storms of this solar cycle. In some cases, like for the St. Patrick's Day storm, users even reported seeing aurora in areas different than aurora models suggested. Online analytics indicate these events drive users to our page and many also share images with various interest groups on social media. While citizen scientists provide observations, Aurorasaurus gives back by providing tools to help the public see and understand the aurora. When people verify auroral sightings in a specific area, the project sends out alerts to nearby users of possible auroral visibility. Aurorasaurus team members around the world also help the public understand the intricacies of space weather and aurora science through blog articles

ScienceToGo.org: Using 'Ozzie the Ostrich' to Build Local Partnerships around Climate Change Learning

NASA Astrophysics Data System (ADS)

Lustick, D. S.; Lohmeier, J.; Chen, R. F.; Wilson, R.; Rabkin, D.; Thompson, S. R.

2015-12-01

How can an informal science learning project about climate change facilitate alliances among unlikely parties? We found a sweet spot of collaboration among private, public, and the non-profit sectors by borrowing strength and leveraging common interests. Using mass transit and out of home media, we created a diverse community around a learning campaign that starred an ostrich named "Ozzie." In 2013-14, ScienceToGo.org ran a series of 12 engaging posters and placards staring 'Ozzie the Ostrich' on the Massachusetts Bay Transit Authority's Red and Orange subway lines targeting a daily audience of 400,000+ riders. The curriculum was divided into three phases: reality, relevance, and hope. Phase I established the reality of climate change (3 months). Phase II helped T-riders appreciate the relevancy of climate change to the local environment of Boston (4 months). Phase III engaged Bostonians with an array of hopeful examples of how people, companies, and organizations are effectively creating a more sustainable future (5 months). The focus of this presentation will be on the relationships that emerged from the work that went into Phase III. Engaging urban populations with climate change science is a difficult challenge since cities seem so removed from the 'natural environment.' However, mass transit provides an inherent means of communicating environmental messages with a cross section of the urban population. Our team felt that any messaging curriculum for an urban subway system must complement the scary reality of a changing climate with hopeful solutions that exist for dealing with it effectively. Urban areas such as Boston must develop adaptation and mitigation strategies that will help them not only survive, but thrive in a changing environment. Making our audience aware of the amazing efforts in this area was the goal of Phase III. There were three parts to our efforts: the signage on the subway, above ground ostriches, and social events. During the presentation

Sciencetogo.Org: Using Humor to Engage a Public Audience with the Serious Issue of Climate Change

NASA Astrophysics Data System (ADS)

Lustick, D. S.; Lohmeier, J.; Chen, R. F.; Rabkin, D.; Wilson, R.

2014-12-01

A team of educators, scientists, and communication experts from multiple universities as well as a Science museum will report on the impact of ScienceToGo.org, which is an Out of Home Multi-Media (OHMM) exhibit targeting adults riding a major subway system. The campaign's goal is to design, implement, and study the efficacy of an OHMM model for free choice science learning about our changing climate. Subway riders represent a diverse and captive audience with most of them spending an average of one hour a day in the subway system. Through the use of specially designed OHMM such as train placards, platform posters, and virtual resources the campaign engages a potential audience of 500,000 riders/day with opportunities to learn climate change science informally. The primary goal of the ScienceToGo.org campaign is to engage, entertain, and educate the adult subway riding community in major U.S. city about climate change as a real, relevant, and solvable local challenge. A naturalistic quasi-experimental inquiry employing a mixed methodology approach best describes our research design with half of the subway system exposed to the project signage (experimental group) and the other half not being exposed to the project signage (control group). To identify possible outcomes, data was collected in the several forms: survey, analytic data associated with website, social media, web app, focus groups, and observations. This campaign is an example of how an individual's daily routine may be enhanced with an informal science learning opportunity. We see an urgent need to improve both the public's engagement with climate change science and to the profile of climate change science in formal education settings. The campaign makes deliberate use of humor and fun to engage a public and diverse audience with the serious issue of climate change. The research that will be presented will reveal some of the strengths and weaknesses of this strategy when communicating science to a diverse

Acute oral administration of the novel, competitive and selective glucocorticoid receptor antagonist ORG 34517 reduces the severity of ethanol withdrawal and related hypothalamic- pituitary-adrenal axis activation

PubMed Central

Reynolds, Anna R.; Saunders, Meredith A.; Brewton, Honoree’ W.; Winchester, Sydney R.; Elgumati, Ibrahim S.; Prendergast, Mark A.

2015-01-01

Background The development of ethanol dependence is associated with alterations in hypothalamic-pituitary-adrenal (HPA) axis and activation of type II glucocorticoid receptors (GR). These effects may contribute to withdrawal-associated anxiety, craving and relapse to drinking. The present studies examined acute and oral administration of the novel, selective and competitive GR antagonist ORG 34517 on the severity of ethanol withdrawal. Methods Adult, male Sprague-Dawley rats were administered ethanol (4g/kg/i.g.) twice daily for 5 days followed by 2 days of withdrawal for 1, 2 or 3 consecutive cycles. Blood ethanol levels (BELs) were determined at 0930 on Day 4 of each week, while blood corticosterone levels (BCLs) were obtained at 1100 hrs on the first day of each ethanol withdrawal. During early withdrawal, subjects received oral administration of ORG 345617 (60 mg/kg/i.g.) or a placebo and withdrawal was monitored. Results Peak BELs of 225.52 mg/dl were observed during the third week. Withdrawal from three cycles of the regimen produced marked behavioral abnormalities (e.g. aggression, rigidity, and hypoactivity) and significant increases in BCLs of ethanol-dependent subjects. Acute, oral administration of ORG 34517 during early withdrawal significantly reduced both the severity of ethanol withdrawal, as reflected in reduced rigidity, aggression, and hypoactivity, and elevations in BCL without producing any sedative-like effects. Conclusions The present findings demonstrate that repeated ethanol exposure and withdrawal is associated with significant behavioral abnormalities and dysregulation of HPA axis activation. Further these data suggest that selective GR antagonists should be further considered as putative pharmacotherapies for treatment of ethanol dependence. PMID:26143299

Acute oral administration of the novel, competitive and selective glucocorticoid receptor antagonist ORG 34517 reduces the severity of ethanol withdrawal and related hypothalamic-pituitary-adrenal axis activation.

PubMed

Reynolds, Anna R; Saunders, Meredith A; Brewton, Honoree' W; Winchester, Sydney R; Elgumati, Ibrahim S; Prendergast, Mark A

2015-09-01

The development of ethanol dependence is associated with alterations in hypothalamic-pituitary-adrenal (HPA) axis and activation of type II glucocorticoid receptors (GR). These effects may contribute to withdrawal-associated anxiety, craving and relapse to drinking. The present studies examined acute and oral administration of the novel, selective and competitive GR antagonist ORG 34517 on the severity of ethanol withdrawal. Adult, male Sprague-Dawley rats were administered ethanol (4g/kg/i.g.) twice daily for 5 days followed by 2 days of withdrawal for 1, 2 or 3 consecutive cycles. Blood ethanol levels (BELs) were determined at 0930 on Day 4 of each week, while blood corticosterone levels (BCLs) were obtained at 11:00hours on the first day of each ethanol withdrawal. During early withdrawal, subjects received oral administration of ORG 345617 (60mg/kg/i.g.) or a placebo and withdrawal was monitored. Peak BELs of 225.52mg/dl were observed during the third week. Withdrawal from three cycles of the regimen produced marked behavioral abnormalities (e.g., aggression, rigidity, and hypoactivity) and significant increases in BCLs of ethanol-dependent subjects. Acute, oral administration of ORG 34517 during early withdrawal significantly reduced both the severity of ethanol withdrawal, as reflected in reduced rigidity, aggression, and hypoactivity, and elevations in BCL without producing any sedative-like effects. The present findings demonstrate that repeated ethanol exposure and withdrawal is associated with significant behavioral abnormalities and dysregulation of HPA axis activation. Further these data suggest that selective GR antagonists should be further considered as putative pharmacotherapies for treatment of ethanol dependence. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

"WWW.MDTF.ORG": a World Wide Web forum for developing open-architecture, freely distributed, digital teaching file software by participant consensus.

PubMed

Katzman, G L; Morris, D; Lauman, J; Cochella, C; Goede, P; Harnsberger, H R

2001-06-01

To foster a community supported evaluation processes for open-source digital teaching file (DTF) development and maintenance. The mechanisms used to support this process will include standard web browsers, web servers, forum software, and custom additions to the forum software to potentially enable a mediated voting protocol. The web server will also serve as a focal point for beta and release software distribution, which is the desired end-goal of this process. We foresee that www.mdtf.org will provide for widespread distribution of open source DTF software that will include function and interface design decisions from community participation on the website forums.

User-friendly solutions for microarray quality control and pre-processing on ArrayAnalysis.org

PubMed Central

Eijssen, Lars M. T.; Jaillard, Magali; Adriaens, Michiel E.; Gaj, Stan; de Groot, Philip J.; Müller, Michael; Evelo, Chris T.

2013-01-01

Quality control (QC) is crucial for any scientific method producing data. Applying adequate QC introduces new challenges in the genomics field where large amounts of data are produced with complex technologies. For DNA microarrays, specific algorithms for QC and pre-processing including normalization have been developed by the scientific community, especially for expression chips of the Affymetrix platform. Many of these have been implemented in the statistical scripting language R and are available from the Bioconductor repository. However, application is hampered by lack of integrative tools that can be used by users of any experience level. To fill this gap, we developed a freely available tool for QC and pre-processing of Affymetrix gene expression results, extending, integrating and harmonizing functionality of Bioconductor packages. The tool can be easily accessed through a wizard-like web portal at http://www.arrayanalysis.org or downloaded for local use in R. The portal provides extensive documentation, including user guides, interpretation help with real output illustrations and detailed technical documentation. It assists newcomers to the field in performing state-of-the-art QC and pre-processing while offering data analysts an integral open-source package. Providing the scientific community with this easily accessible tool will allow improving data quality and reuse and adoption of standards. PMID:23620278

Org-1-dependent lineage reprogramming generates the ventral longitudinal musculature of the Drosophila heart.

PubMed

Schaub, Christoph; März, Johannes; Reim, Ingolf; Frasch, Manfred

2015-02-16

Only few examples of transdifferentiation, which denotes the conversion of one differentiated cell type to another, are known to occur during normal development, and more often, it is associated with regeneration processes. With respect to muscles, dedifferentiation/redifferentiation processes have been documented during post-traumatic muscle regeneration in blastema of newts as well as during myocardial regeneration. As shown herein, the ventral longitudinal muscles of the adult Drosophila heart arise from specific larval alary muscles in a process that represents the first known example of syncytial muscle transdifferentiation via dedifferentiation into mononucleate myoblasts during normal development. We demonstrate that this unique process depends on the reinitiation of a transcriptional program previously employed for embryonic alary muscle development, in which the factors Org-1 (Drosophila Tbx1) and Tailup (Drosophila Islet1) are key components. During metamorphosis, the action of these factors is combined with cell-autonomous inputs from the ecdysone steroid and the Hox gene Ultrabithorax, which provide temporal and spatial specificity to the transdifferentiation events. Following muscle dedifferentiation, inductive cues, particularly from the remodeling heart tube, are required for the redifferentiation of myoblasts into ventral longitudinal muscles. Our results provide new insights into mechanisms of lineage commitment and cell-fate plasticity during development. Copyright © 2015 Elsevier Ltd. All rights reserved.

GetHealthyHarlem.org: Developing a Web Platform for Health Promotion and Wellness Driven by and for the Harlem Community

PubMed Central

Khan, Sharib A.; Ancker, Jessica S.; Li, Jianhua; Kaufman, David; Hutchinson, Carly; Cohall, Alwyn; Kukafka, Rita

2009-01-01

GetHealthyHarlem.org is a community website developed on an open-source platform to facilitate collaborative development of health content through participatory action research (PAR) principles. The website was developed to enable the Harlem community to create a shared health and wellness knowledgebase, to enable discourse about local and culturally relevant health information, and to foster social connections between community members and health promotion organizations. The site is gaining active use with more than 9,500 unique site visits in the six months since going live in November, 2008. In ongoing research studies, we are using the website to explore how the PAR model can be applied to the development of a community health website. PMID:20351872

PlanYourLifeSpan.org - an intervention to help seniors make choices for their fourth quarter of life: Results from the randomized clinical trial.

PubMed

Lindquist, Lee A; Ramirez-Zohfeld, Vanessa; Sunkara, Priya D; Forcucci, Chris; Campbell, Dianne S; Mitzen, Phyllis; Ciolino, Jody D; Gregory, Dyanna; Kricke, Gayle; Cameron, Kenzie A

2017-11-01

Few older adults contemplate their home support and health needs that may be required for aging-in-place. We sought to assess the efficacy of PlanYourLifespan.org (PYL), in influencing seniors' planning behaviors, perception of the importance of planning, and confidence accessing services. Randomized controlled trial, of adults, age ≥65 years in urban, suburban, rural areas of Texas, Illinois, Indiana. Among 385 participants, mean age was 71.9 years, 79.5% female. Between baseline and one-month follow-up, average planning behavior score increased 0.22 points in the PYL arm when compared to the attention control (AC) arm. After controlling for baseline, mean one-month planning behavior score was significantly higher in the PYL arm than in the AC arm (1.25 points, CI 0.37-2.12, p=0.005). Secondary analyses via longitudinal linear mixed modelling suggested a study arm-by-time interaction effect for both planning behavior (p=0.047 and perception of importance (p=0.05). Significant baseline covariates included self-efficacy, education, perceived social support, power of attorney, and history of stroke. PlanYourLifespan.org demonstrated efficacy in helping seniors plan for and communicate their health support needs. This free, nationally available tool may help individuals understand, plan, and communicate their options for their future support needs. Copyright © 2017 Elsevier B.V. All rights reserved.

The StarDate Black Hole Encyclopedia Website blackholes.stardate.org

NASA Astrophysics Data System (ADS)

Gebhardt, Karl; Benningfield, D.; Preston, S.

2013-01-01

The StarDate Black Hole Encyclopedia website was developed over the past seven years to provide an extensive but easy-to-read resource for the public and students. A Spanish-language version, Enciclopedia de agujeros negros, is also available at blackholes.radiouniverso.org. Evaluation shows that the sites are used by the public, students, and astronomy professionals, and the site is among the top references in most web searches for individual black holes. The site comprises seven major subsections: Basics, Directory, Research, History, Pop Culture, News, and Resources. The Basics section introduces black holes, explains how they are discovered and studied, and covers their basis in the theory of gravity. This section also includes a six-minute video introduction, “Black Holes: Stranger than Fiction.” The Directory section contains extensive descriptions of more than 80 well-known stellar, intermediate, and supermassive black holes as well as images and vital statistics of each. The Research section takes a look at three NSF-funded projects, including the work of Andrea Ghez, Karl Gebhardt and Jenny Greene, and the LIGO project. The History section provides a timeline of black holes from Isaac Newton to the present. Some of the best and worst roles played by black holes in films, TV shows, and books are included in the Pop Culture section (and pop culture references and images are sprinkled through the rest of the site). An archive of news reports about black holes is available in the News section, which provides links to the original stories or press releases. And the Resources section offers FAQs, articles from StarDate magazine and radio programs, activities for students that are tied to national standards, a glossary, and a reading list of books and websites. We have conducted both quantitative and qualitative evaluation on the black hole websites. This material is based upon work supported by the National Science Foundation under Grant No. 0935841. Any

WormClassroom.org: An Inquiry-rich Educational Web Portal for Research Resources of Caenorhabditis elegans

PubMed Central

Lu, Fong-Mei; Stewart, James; White, John G.

2007-01-01

The utilization of biology research resources, coupled with a “learning by inquiry” approach, has great potential to aid students in gaining an understanding of fundamental biological principles. To help realize this potential, we have developed a Web portal for undergraduate biology education, WormClassroom.org, based on current research resources of a model research organism, Caenorhabditis elegans. This portal is intended to serve as a resource gateway for students to learn biological concepts using C. elegans research material. The driving forces behind the WormClassroom website were the strengths of C. elegans as a teaching organism, getting researchers and educators to work together to develop instructional materials, and the 3 P's (problem posing, problem solving, and peer persuasion) approach for inquiry learning. Iterative assessment is an important aspect of the WormClassroom site development because it not only ensures that content is up-to-date and accurate, but also verifies that it does, in fact, aid student learning. A primary assessment was performed to refine the WormClassroom website utilizing undergraduate biology students and nonstudent experts such as C. elegans researchers; results and comments were used for site improvement. We are actively encouraging continued resource contributions from the C. elegans research and education community for the further development of WormClassroom. PMID:17548872

Agroclimate.Org: Tools and Information for a Climate Resilient Agriculture in the Southeast USA

NASA Astrophysics Data System (ADS)

Fraisse, C.

2014-12-01

AgroClimate (http://agroclimate.org) is a web-based system developed to help the agricultural industry in the southeastern USA reduce risks associated with climate variability and change. It includes climate related information and dynamic application tools that interact with a climate and crop database system. Information available includes climate monitoring and forecasts combined with information about crop management practices that help increase the resiliency of the agricultural industry in the region. Recently we have included smartphone apps in the AgroClimate suite of tools, including irrigation management and crop disease alert systems. Decision support tools available in AgroClimate include: (a) Climate risk: expected (probabilistic) and historical climate information and freeze risk; (b) Crop yield risk: expected yield based on soil type, planting date, and basic management practices for selected commodities and historical county yield databases; (c) Crop diseases: disease risk monitoring and forecasting for strawberry and citrus; (d) Crop development: monitoring and forecasting of growing degree-days and chill accumulation; (e) Drought: monitoring and forecasting of selected drought indices, (f) Footprints: Carbon and water footprint calculators. The system also provides background information about the main drivers of climate variability and basic information about climate change in the Southeast USA. AgroClimate has been widely used as an educational tool by the Cooperative Extension Services in the region and also by producers. It is now being replicated internationally with version implemented in Mozambique and Paraguay.

Eodataservice.org: Big Data Platform to Enable Multi-disciplinary Information Extraction from Geospatial Data

NASA Astrophysics Data System (ADS)

Natali, S.; Mantovani, S.; Barboni, D.; Hogan, P.

2017-12-01

In 1999, US Vice-President Al Gore outlined the concept of `Digital Earth' as a multi-resolution, three-dimensional representation of the planet to find, visualise and make sense of vast amounts of geo- referenced information on physical and social environments, allowing to navigate through space and time, accessing historical and forecast data to support scientists, policy-makers, and any other user. The eodataservice platform (http://eodataservice.org/) implements the Digital Earth Concept: eodatasevice is a cross-domain platform that makes available a large set of multi-year global environmental collections allowing data discovery, visualization, combination, processing and download. It implements a "virtual datacube" approach where data stored on distributed data centers are made available via standardized OGC-compliant interfaces. Dedicated web-based Graphic User Interfaces (based on the ESA-NASA WebWorldWind technology) as well as web-based notebooks (e.g. Jupyter notebook), deskop GIS tools and command line interfaces can be used to access and manipulate the data. The platform can be fully customized on users' needs. So far eodataservice has been used for the following thematic applications: High resolution satellite data distribution Land surface monitoring using SAR surface deformation data Atmosphere, ocean and climate applications Climate-health applications Urban Environment monitoring Safeguard of cultural heritage sites Support to farmers and (re)-insurances in the agriculturés field In the current work, the EO Data Service concept is presented as key enabling technology; furthermore various examples are provided to demonstrate the high level of interdisciplinarity of the platform.

A new website to aid the interpretation of antemortem dental records:www.internationaldentalcharts.org.

PubMed

Manica, Scheila

2014-12-01

The INTERPOL (International Police Organization) Disaster Victim Identification forms represent a global standard for mass disasters and the collection of international ante-mortem dental records. These records can now be interpreted more easily with the help of a new online dictionary of dental terminology for translating dental charts from several languages into English. The free website launched in 2013 (www.internationaldentalcharts.org) is the result of a M.Sc project on international dental charts: Guide of International Dental Charts translated into English decoding international ante-mortem dental charts for INTERPOL's Ante-mortem (AM) Disaster Victim Identification (DVI) forms (Section F2), completed in 2011. The aim of this study was to analyze the tooth numbering system, symbols and abbreviations used on dental charting worldwide. A letter was sent to the national dental associations of the 188 INTERPOL member countries, addressing the goals of the project and asking for samples of dental charts. A total of 45 countries replied and 32 common dental alterations were selected for translation, such as: decay, filling and extraction. Their symbols and/or abbreviations used were summarized in various languages. More than one system of dental notations was used in the same country whereas there was an absence of standard systems in other countries. Some of the samples of charts received were of little value. However, a fair amount of useful information and detail was found in most of them. This free consultation website could be useful when the handwriting, symbols, and abbreviations on the ante-mortem dental charts are not clear. It will be particularly applicable when ante-mortem xrays and casts are not available.

NeuroVault.org: A repository for sharing unthresholded statistical maps, parcellations, and atlases of the human brain.

PubMed

Gorgolewski, Krzysztof J; Varoquaux, Gael; Rivera, Gabriel; Schwartz, Yannick; Sochat, Vanessa V; Ghosh, Satrajit S; Maumet, Camille; Nichols, Thomas E; Poline, Jean-Baptiste; Yarkoni, Tal; Margulies, Daniel S; Poldrack, Russell A

2016-01-01

NeuroVault.org is dedicated to storing outputs of analyses in the form of statistical maps, parcellations and atlases, a unique strategy that contrasts with most neuroimaging repositories that store raw acquisition data or stereotaxic coordinates. Such maps are indispensable for performing meta-analyses, validating novel methodology, and deciding on precise outlines for regions of interest (ROIs). NeuroVault is open to maps derived from both healthy and clinical populations, as well as from various imaging modalities (sMRI, fMRI, EEG, MEG, PET, etc.). The repository uses modern web technologies such as interactive web-based visualization, cognitive decoding, and comparison with other maps to provide researchers with efficient, intuitive tools to improve the understanding of their results. Each dataset and map is assigned a permanent Universal Resource Locator (URL), and all of the data is accessible through a REST Application Programming Interface (API). Additionally, the repository supports the NIDM-Results standard and has the ability to parse outputs from popular FSL and SPM software packages to automatically extract relevant metadata. This ease of use, modern web-integration, and pioneering functionality holds promise to improve the workflow for making inferences about and sharing whole-brain statistical maps. Copyright © 2015 Elsevier Inc. All rights reserved.

Microbubble signal and trial of org in acute stroke treatment (TOAST) classification in ischemic stroke.

PubMed

Lee, Chan-Hyuk; Kang, Hyun Goo; Lee, Ji Sung; Ryu, Han Uk; Jeong, Seul-Ki

2018-07-15

Right-to-left shunt (RLS) through a patent foramen ovale (PFO) is likely associated with ischemic stroke. Many studies have attempted to demonstrate the association between RLS and ischemic stroke. However, information on the association between the degree of RLS and the subtypes of ischemic stroke categorized by the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification is lacking. This was a retrospective study involving 508 patients with ischemic stroke who underwent a transcranial Doppler (TCD) microbubble test between 2013 and 2015. The degree of RLS was divided into 4 grades according to the microbubble signal (MBS) as follows: no MBS, grade 1; MBS < 20, grade 2; MBS > 20, grade 3; curtain sign, grade 4. The degree of RLS and the type of ischemic stroke as classified by TOAST were analyzed and compared with other clinical information and laboratory findings. The higher RLS grade was associated with the cardioembolism (CE) and stroke of undetermined etiology (SUE), and the microbubble signals were inversely related with small vessel disease (SVD). An MBS higher than grade 3 showed a 2.95-fold higher association with SUE than large artery atherosclerosis (LAA), while grade 4 MBS revealed an approximately 8-fold higher association with SUE than LAA. RLS identified by the TCD microbubble test was significantly and independently associated with cryptogenic ischemic stroke (negative evaluation). Subsequent studies are needed to determine the biologic relationship between RLS and ischemic stroke, particularly the cryptogenic subtype of ischemic stroke. Copyright © 2018 Elsevier B.V. All rights reserved.

[New international networks in radiology graduate and continuing education: www.eurorad.org--a EAR Project for online publication of radiological data].

PubMed

Vorwerk, D

2002-02-01

Eurorad (www.eurorad.org) is a joint project of EAR and has support of 27 national and 8 subspeciality radiology societies. Eurorad is the first noncommercial radiological publication that is exclusively based on the internet as a communication line with all steps of submission, reviewing and publication being performed online. Eurorad wants to build up a huge and exhaustive case file of diagnostic and interventional radiology. Like all scientific publications, Eurorad bases on an editor in chief and 13 section editors who are responsible for organizing each section of Eurorad. Each section has a number of peer reviewer with an overall total of more than 100. For submission and publication, all cases are structured in the same manner with case report, method and discussion. For the time being, Eurorad hosts 779 cases, of whom 346 are free available on the net. The actual rejection rate is 4.5%, other cases are under review.

hemaClass.org: Online One-By-One Microarray Normalization and Classification of Hematological Cancers for Precision Medicine.

PubMed

Falgreen, Steffen; Ellern Bilgrau, Anders; Brøndum, Rasmus Froberg; Hjort Jakobsen, Lasse; Have, Jonas; Lindblad Nielsen, Kasper; El-Galaly, Tarec Christoffer; Bødker, Julie Støve; Schmitz, Alexander; H Young, Ken; Johnsen, Hans Erik; Dybkær, Karen; Bøgsted, Martin

2016-01-01

Dozens of omics based cancer classification systems have been introduced with prognostic, diagnostic, and predictive capabilities. However, they often employ complex algorithms and are only applicable on whole cohorts of patients, making them difficult to apply in a personalized clinical setting. This prompted us to create hemaClass.org, an online web application providing an easy interface to one-by-one RMA normalization of microarrays and subsequent risk classifications of diffuse large B-cell lymphoma (DLBCL) into cell-of-origin and chemotherapeutic sensitivity classes. Classification results for one-by-one array pre-processing with and without a laboratory specific RMA reference dataset were compared to cohort based classifiers in 4 publicly available datasets. Classifications showed high agreement between one-by-one and whole cohort pre-processsed data when a laboratory specific reference set was supplied. The website is essentially the R-package hemaClass accompanied by a Shiny web application. The well-documented package can be used to run the website locally or to use the developed methods programmatically. The website and R-package is relevant for biological and clinical lymphoma researchers using affymetrix U-133 Plus 2 arrays, as it provides reliable and swift methods for calculation of disease subclasses. The proposed one-by-one pre-processing method is relevant for all researchers using microarrays.

Thanks to 70 years of Inter American Statistical cooperation, the world's largest integrated census microdata dissemination site www.ipums.org/international.

PubMed

McCAA, Robert

2013-06-01

Seventy years of Inter American Statistical cooperation, symbolized by the 70 th anniversary of Estadística , made possible the construction of IPUMS-International, the world's largest integrated census microdata dissemination site, www.ipums.org/international. Currently, the site offers access to 238 samples totaling over 540 million person records representing 74 countries. The Americas, which account for only about one-seventh of the world's population, amount to over one-third (36%) of the person records in the IPUMS-International database. Likewise, 35% of the citations in the IPUMS-International bibliography are for studies focused on Latin America, with about half of these analyzing a single Latin American country. This article discusses salient features of the IPUMS integration methods and system. National Statistical Institutes that have not yet entrusted 2010 census microdata to the initiative are invited to do so. Researchers and teachers are invited to use the data freely in analysis and teaching. Setenta años de cooperación estadística inter-Americana, simbolizada por el 70 aniversario de la revista Estadística , han hecho posible la construcción de IPUMS-internacional, la base en línea de microdatos censales harmonizados más grande del mundo, www.ipums.org/international. Actualmente, IPUMS proporciona acceso a 238 muestras con más de 540 millones de registros individuales de 74 países. Las Américas, que albergan una séptima parte de la población mundial, representan más de un tercio (36%) de todos los registros individuales en la base de datos IPUMS-internacional. Asimismo, el 35% de todas las referencias en la bibliografía de IPUMS son de estudios realizados sobre América Latina, la mitad de éstas basadas en un sólo país de la región. Este artículo presenta las principales características del sistema de integración y difusión de datos de IPUMS. Los Institutos Nacionales de Estadísticas que todavía no ha entregado la muestra

Climatevoices.org -- Engaging an Array of U.S. Public Audiences in the Science of Climate Change

NASA Astrophysics Data System (ADS)

Schmidt, C.

2014-12-01

A significant number of U.S. citizens have real concerns that actions to curb climate change threaten prosperity and basic freedoms and present an affront to their own values. Others are so worried that climate change will destroy Earth's environment and any prospects for their descendants that they are either frantic to find solutions, or too discouraged to act. To attempt to reach these disparate audiences with critical scientific information from reports such as the IPCC and NCA, the University Corporation for Atmospheric Research and the United Nations Foundation initiated the Scientist Citizen Initiative, and launched Climate Voices - Science Speakers Network (climatevoices.org) in April of this year. This presentation will address the trials and errors of establishing such a network, engaging scientists across the country, and creating public demand for such a resource. The major focus will be lessons still being learned about reaching diverse local audiences; gauging and implementing the varied approach necessary to engage such audiences; and enabling scientists to initiate public conversations involving fellow citizens in discussion of climate change observations, impacts, and solutions. How can partners be identified and involved that deliver mixed audiences ranging from the Six Americas' "alarmed and concerned" to the "doubtful and dismissive?" [Yale Project on Climate Communication] How can synthesis report results be made compelling and relevant to such audiences? How can such an effort be implemented across the entire country? How can its accomplishments and failures be assessed and evaluated? This presentation will provide answers in progress to these questions.

Differences in Characteristics and Outcomes Between Asian and Non-Asian Patients in the TIAregistry.org.

PubMed

Hoshino, Takao; Uchiyama, Shinichiro; Wong, Lawrence K S; Sissani, Leila; Albers, Gregory W; Bornstein, Natan M; Caplan, Louis R; Donnan, Geoffrey A; Ferro, José M; Hennerici, Michael G; Labreuche, Julien; Lavallée, Philippa C; Molina, Carlos; Rothwell, Peter M; Steg, Philippe Gabriel; Touboul, Pierre-Jean; Vicaut, Éric; Amarenco, Pierre

2017-07-01

This study provides the contemporary causes and prognosis of transient ischemic attack (TIA) and minor stroke in Asians and the direct comparisons with non-Asians. The TIAregistry.org enrolled 4789 patients (1149 Asians and 3640 non-Asians) with a TIA or minor ischemic stroke within 7 days of onset. Every participating facility had systems dedicated to urgent intervention of TIA/stroke patients by specialists. The primary outcome was a composite of cardiovascular death, nonfatal stroke, and nonfatal acute coronary syndrome. Approximately 80% of patients were evaluated within 24 hours of symptom onset. At 1 year, there were no differences in the rates of composite cardiovascular events (6.8% versus 6.0%; P =0.38) and stroke (6.0% versus 4.8%; P =0.11) between Asians and non-Asians. Asians had a lower risk of cerebrovascular disease (stroke or TIA) than non-Asians (adjusted hazard ratio, 0.79; 95% confidence interval, 0.63-0.98; P =0.03); the difference was primarily driven by a lower rate of TIA in Asians (4.2% versus 8.3%; P <0.001). Moderately severe bleeding was more frequent in Asians (0.8% versus 0.3%; P =0.02). In multivariable analysis, multiple acute infarcts ( P =0.005) and alcohol consumption ( P =0.02) were independent predictors of stroke recurrence in Asians, whereas intracranial stenosis ( P <0.001), ABCD 2 score ( P <0.001), atrial fibrillation ( P =0.008), extracranial stenosis ( P =0.03), and previous stroke or TIA ( P =0.03) were independent predictors in non-Asians. The short-term stroke risk after a TIA or minor stroke was lower than expected when urgent evidence-based care was delivered, irrespective of race/ethnicity or region. However, the predictors of stroke were different for Asians and non-Asians. © 2017 American Heart Association, Inc.

Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease.

PubMed

Moskalev, Alexey; Chernyagina, Elizaveta; de Magalhães, João Pedro; Barardo, Diogo; Thoppil, Harikrishnan; Shaposhnikov, Mikhail; Budovsky, Arie; Fraifeld, Vadim E; Garazha, Andrew; Tsvetkov, Vasily; Bronovitsky, Evgeny; Bogomolov, Vladislav; Scerbacov, Alexei; Kuryan, Oleg; Gurinovich, Roman; Jellen, Leslie C; Kennedy, Brian; Mamoshina, Polina; Dobrovolskaya, Evgeniya; Aliper, Alex; Kaminsky, Dmitry; Zhavoronkov, Alex

2015-09-01

As the level of interest in aging research increases, there is a growing number of geroprotectors, or therapeutic interventions that aim to extend the healthy lifespan and repair or reduce aging-related damage in model organisms and, eventually, in humans. There is a clear need for a manually-curated database of geroprotectors to compile and index their effects on aging and age-related diseases and link these effects to relevant studies and multiple biochemical and drug databases. Here, we introduce the first such resource, Geroprotectors (http://geroprotectors.org). Geroprotectors is a public, rapidly explorable database that catalogs over 250 experiments involving over 200 known or candidate geroprotectors that extend lifespan in model organisms. Each compound has a comprehensive profile complete with biochemistry, mechanisms, and lifespan effects in various model organisms, along with information ranging from chemical structure, side effects, and toxicity to FDA drug status. These are presented in a visually intuitive, efficient framework fit for casual browsing or in-depth research alike. Data are linked to the source studies or databases, providing quick and convenient access to original data. The Geroprotectors database facilitates cross-study, cross-organism, and cross-discipline analysis and saves countless hours of inefficient literature and web searching. Geroprotectors is a one-stop, knowledge-sharing, time-saving resource for researchers seeking healthy aging solutions.

Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease

PubMed Central

Moskalev, Alexey; Chernyagina, Elizaveta; de Magalhães, João Pedro; Barardo, Diogo; Thoppil, Harikrishnan; Shaposhnikov, Mikhail; Budovsky, Arie; Fraifeld, Vadim E.; Garazha, Andrew; Tsvetkov, Vasily; Bronovitsky, Evgeny; Bogomolov, Vladislav; Scerbacov, Alexei; Kuryan, Oleg; Gurinovich, Roman; Jellen, Leslie C.; Kennedy, Brian; Mamoshina, Polina; Dobrovolskaya, Evgeniya; Aliper, Alex; Kaminsky, Dmitry; Zhavoronkov, Alex

2015-01-01

As the level of interest in aging research increases, there is a growing number of geroprotectors, or therapeutic interventions that aim to extend the healthy lifespan and repair or reduce aging-related damage in model organisms and, eventually, in humans. There is a clear need for a manually-curated database of geroprotectors to compile and index their effects on aging and age-related diseases and link these effects to relevant studies and multiple biochemical and drug databases. Here, we introduce the first such resource, Geroprotectors (http://geroprotectors.org). Geroprotectors is a public, rapidly explorable database that catalogs over 250 experiments involving over 200 known or candidate geroprotectors that extend lifespan in model organisms. Each compound has a comprehensive profile complete with biochemistry, mechanisms, and lifespan effects in various model organisms, along with information ranging from chemical structure, side effects, and toxicity to FDA drug status. These are presented in a visually intuitive, efficient framework fit for casual browsing or in-depth research alike. Data are linked to the source studies or databases, providing quick and convenient access to original data. The Geroprotectors database facilitates cross-study, cross-organism, and cross-discipline analysis and saves countless hours of inefficient literature and web searching. Geroprotectors is a one-stop, knowledge-sharing, time-saving resource for researchers seeking healthy aging solutions. PMID:26342919

Thanks to 70 years of Inter American Statistical cooperation, the world’s largest integrated census microdata dissemination site www.ipums.org/international

PubMed Central

McCAA, ROBERT

2014-01-01

Seventy years of Inter American Statistical cooperation, symbolized by the 70th anniversary of Estadística, made possible the construction of IPUMS-International, the world’s largest integrated census microdata dissemination site, www.ipums.org/international. Currently, the site offers access to 238 samples totaling over 540 million person records representing 74 countries. The Americas, which account for only about one-seventh of the world’s population, amount to over one-third (36%) of the person records in the IPUMS-International database. Likewise, 35% of the citations in the IPUMS-International bibliography are for studies focused on Latin America, with about half of these analyzing a single Latin American country. This article discusses salient features of the IPUMS integration methods and system. National Statistical Institutes that have not yet entrusted 2010 census microdata to the initiative are invited to do so. Researchers and teachers are invited to use the data freely in analysis and teaching. Setenta años de cooperación estadística inter-Americana, simbolizada por el 70 aniversario de la revista Estadística, han hecho posible la construcción de IPUMS-internacional, la base en línea de microdatos censales harmonizados más grande del mundo, www.ipums.org/international. Actualmente, IPUMS proporciona acceso a 238 muestras con más de 540 millones de registros individuales de 74 países. Las Américas, que albergan una séptima parte de la población mundial, representan más de un tercio (36%) de todos los registros individuales en la base de datos IPUMS-internacional. Asimismo, el 35% de todas las referencias en la bibliografía de IPUMS son de estudios realizados sobre América Latina, la mitad de éstas basadas en un sólo país de la región. Este artículo presenta las principales características del sistema de integración y difusión de datos de IPUMS. Los Institutos Nacionales de Estadísticas que todavía no ha entregado la muestra

ScienceToGo.org: The Strengths and Weaknesses of Communicating Climate Change through Mass Transit Advertising Spaces

NASA Astrophysics Data System (ADS)

Lustick, D. S.; Lohmeier, J.; Chen, R. F.; Wilson, R.; Rabkin, D.; Thompson, S. R.

2016-02-01

Engaging urban populations with climate change science is a difficult challenge since cities can seem so removed from the `natural environment.' However, mass transit provides an inherent means of communicating environmental messages with a cross section of the urban population. The Out of Home Media (OHM) spaces found on platforms and inside train cars provide a potentially effective means of bringing informal science learning opportunities directly to an underserved STEM audience. Our team felt that any messaging curriculum for a coastal urban subway system must complement the scary reality of the impacts of a changing climate (i.e. rising sea levels) with current examples of how the city is preparing for a more sustainable future. Urban areas such as Boston must develop adaptation and mitigation strategies that will help them not only survive, but thrive in a changing environment. In 2013-14, ScienceToGo.org ran a series of 12 engaging posters and placards staring `Ozzie the Ostrich' on the Massachusetts Bay Transit Authority's Red and Orange subway lines targeting an audience of more than 400,000 riders per day. The 12 month curriculum was divided into three phases: reality, relevance, and hope. During the presentation, we will present the results of our quasi-experimental research which identifies, quantifies, and explains the observed impacts of the campaign on adult riders. The strengths and weaknesses of the communication strategy will be discussed. Finally, we will conclude with some recommendations for how this work could improve and inform other urban informal science learning initiatives.

Comparison of the Chinese ischemic stroke subclassification and Trial of Org 10172 in acute stroke treatment systems in minor stroke.

PubMed

Tan, Sha; Zhang, Lei; Chen, Xiaoyu; Wang, Yanqiang; Lin, Yinyao; Cai, Wei; Shan, Yilong; Qiu, Wei; Hu, Xueqiang; Lu, Zhengqi

2016-09-06

The underlying causes of minor stroke are difficult to assess. Here, we evaluate the reliability of the Chinese Ischemic Stroke Subclassification (CISS) system in patients with minor stroke, and compare it to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) system. A total of 320 patients with minor stroke were retrospectively registered and categorized into different subgroups of the CISS and TOAST by two neurologists. Inter- and intra-rater agreement with the two systems were assessed with kappa statistics. The percentage of undetermined etiology (UE) cases in the CISS system was 77.3 % less than that in the TOAST system, which was statistically significant (P < 0.001). The percentage of large artery atherosclerosis (LAA) in the CISS system was 79.7 % more than that in the TOAST system, which was also statistically significant (P < 0.001). The kappa values for inter-examiner agreement were 0.898 (P = 0.031) and 0.732 (P = 0.022) for the CISS and TOAST systems, respectively. The intra-observer reliability indexes were moderate (0.569 for neurologist A, and 0.487 for neurologist B). The CISS and TOAST systems are both reliable in classifying patients with minor stroke. CISS classified more patients into known etiologic categories without sacrificing reliability.

Optimally combined regional geoid models for the realization of height systems in developing countries - ORG4heights

NASA Astrophysics Data System (ADS)

Lieb, Verena; Schmidt, Michael; Willberg, Martin; Pail, Roland

2017-04-01

Precise height systems require high-resolution and high-quality gravity data. However, such data sets are sparse especially in developing or newly industrializing countries. Thus, we initiated the DFG-project "ORG4heights" for the formulation of a general scientific concept how to (1) optimally combine all available data sets and (2) estimate realistic errors. The resulting regional gravity field models then deliver the fundamental basis for (3) establishing physical national height systems. The innovative key aspects of the project incorporate the development of a method which links (low- up to mid-resolution) gravity satellite mission data and (high- down to low-quality) terrestrial data. Hereby, an optimal combination of the data utilizing their highest measure of information including uncertainty quantification and analyzing systematic omission errors is pursued. Regional gravity field modeling via Multi-Resolution Representation (MRR) and Least Squares Collocation (LSC) are studied in detail and compared based on their theoretical fundamentals. From the findings, MRR shall be further developed towards implementing a pyramid algorithm. Within the project, we investigate comprehensive case studies in Saudi Arabia and South America, i. e. regions with varying topography, by means of simulated data with heterogeneous distribution, resolution, quality and altitude. GPS and tide gauge records serve as complementary input or validation data. The resulting products include error propagation, internal and external validation. A generalized concept then is derived in order to establish physical height systems in developing countries. The recommendations may serve as guidelines for sciences and administration. We present the ideas and strategies of the project, which combines methodical development and practical applications with high socio-economic impact.

HIV Risk and Substance Use in Men Who Have Sex with Men Surveyed in Bathhouses, Bars/Clubs, and on Craigslist.org: Venue of Recruitment Matters

PubMed Central

Grov, Christian

2018-01-01

There has been little evaluation regarding whether men who have sex with men (MSM) recruited in one type of venue differ in behavioral and demographic characteristics from those recruited in others. We surveyed MSM in gay bars/clubs (n = 199), bathhouses (n = 194), and off Craigslist.org (n = 208). Men in bathhouses reported the greatest average number of partners and were less likely to disclose their HIV status. Among men reporting anal sex; those on Craigslist reported the least condom use. Finally, men surveyed in gay bars/clubs were the youngest of the three and the most likely to be single; they also reported the highest levels of attachment to the gay community and the most frequent alcohol use. Our findings demonstrate the need to tailor HIV prevention efforts to the location in which they are targeted, and for researchers to evaluate if participants differ by recruitment source. PMID:21748276

HIV risk and substance use in men who have sex with men surveyed in bathhouses, bars/clubs, and on Craigslist.org: venue of recruitment matters.

PubMed

Grov, Christian

2012-05-01

There has been little evaluation regarding whether men who have sex with men (MSM) recruited in one type of venue differ in behavioral and demographic characteristics from those recruited in others. We surveyed MSM in gay bars/clubs (n = 199), bathhouses (n = 194), and off Craigslist.org (n = 208). Men in bathhouses reported the greatest average number of partners and were less likely to disclose their HIV status. Among men reporting anal sex; those on Craigslist reported the least condom use. Finally, men surveyed in gay bars/clubs were the youngest of the three and the most likely to be single; they also reported the highest levels of attachment to the gay community and the most frequent alcohol use. Our findings demonstrate the need to tailor HIV prevention efforts to the location in which they are targeted, and for researchers to evaluate if participants differ by recruitment source.

Seeing the doctor without fear: www.doctortea.org for the desensitization for medical visits in Autism Spectrum Disorders.

PubMed

Boada, Leticia; Parellada, Mara

Doctor Tea is an online website designed to facilitate medical visits for those with autism spectrum disorder and other disabilities. People diagnosed with autism not only have greater medical needs than the general population, but also have particular characteristics that are often not accommodated by medical services. This lack of medical accommodation often creates a very complicated, and sometimes traumatic experience, when visiting medical facilities. Individuals with autism have great difficulty understanding social situations and contexts, such as medical tests or consultations, as well as difficulty in tolerating new situations and atypical sensory thresholds. Doctor Tea aims to reduce anxiety before medical consultations and procedures from a safe and well-known environment (school, home, etc.). The website, www.doctortea.org, provides information and materials (videos, cartoon, 3D animations, pictogram sequences, etc.) about the most frequent medical procedures and practices for patients with autism. The website also offers information to the doctors and families of patients with autism about the most common medical problems associated with autism. A total of 17,199 different users visited the website during 2015, with a total of 23,348 online visitors from more than 70 different countries since the website's release in November 2014. The familiarisation with the medical procedures and its environment appears to decrease the anxiety in patients with disabilities during medical visits, as well as optimising the effectiveness of their medical visits and tests. Copyright © 2016 SEP y SEPB. Publicado por Elsevier España, S.L.U. All rights reserved.

Efficiently Communicating Rich Heterogeneous Geospatial Data from the FeMO2008 Dive Cruise with FlashMap on EarthRef.org

NASA Astrophysics Data System (ADS)

Minnett, R. C.; Koppers, A. A.; Staudigel, D.; Staudigel, H.

2008-12-01

EarthRef.org is comprehensive and convenient resource for Earth Science reference data and models. It encompasses four main portals: the Geochemical Earth Reference Model (GERM), the Magnetics Information Consortium (MagIC), the Seamount Biogeosciences Network (SBN), and the Enduring Resources for Earth Science Education (ERESE). Their underlying databases are publically available and the scientific community has contributed widely and is urged to continue to do so. However, the net result is a vast and largely heterogeneous warehouse of geospatial data ranging from carefully prepared maps of seamounts to geochemical data/metadata, daily reports from seagoing expeditions, large volumes of raw and processed multibeam data, images of paleomagnetic sampling sites, etc. This presents a considerable obstacle for integrating other rich media content, such as videos, images, data files, cruise tracks, and interoperable database results, without overwhelming the web user. The four EarthRef.org portals clearly lend themselves to a more intuitive user interface and has, therefore, been an invaluable test bed for the design and implementation of FlashMap, a versatile KML-driven geospatial browser written for reliability and speed in Adobe Flash. FlashMap allows layers of content to be loaded and displayed over a streaming high-resolution map which can be zoomed and panned similarly to Google Maps and Google Earth. Many organizations, from National Geographic to the USGS, have begun using Google Earth software to display geospatial content. However, Google Earth, as a desktop application, does not integrate cleanly with existing websites requiring the user to navigate away from the browser and focus on a separate application and Google Maps, written in Java Script, does not scale up reliably to large datasets. FlashMap remedies these problems as a web-based application that allows for seamless integration of the real-time display power of Google Earth and the flexibility of

Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of bridging research in support of phase II dose selection.

PubMed

Nations, Kari R; Bursi, Roberta; Dogterom, Peter; Ereshefsky, Larry; Gertsik, Lev; Mant, Tim; Schipper, Jacques

2012-09-01

A key challenge to dose selection in early central nervous system (CNS) clinical drug development is that patient tolerability profiles often differ from those of healthy volunteers (HVs), yet HVs are the modal population for determining doses to be investigated in phase II trials. Without clear tolerability data from the target patient population, first efficacy trials may include doses that are either too high or too low, creating undue risk for study participants and the development program overall. Bridging trials address this challenge by carefully investigating safety and tolerability in the target population prior to full-scale proof-of-concept trials. Org 26576 is an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor positive allosteric modulator that acts by modulating ionotropic AMPA-type glutamate receptors to enhance glutamatergic neurotransmission. In preparation for phase II efficacy trials in major depressive disorder (MDD), two separate phase I trials were conducted to evaluate safety, tolerability, and pharmacokinetics in HVs and in the target patient population. Both trials were randomized and placebo controlled, and included multiple rising-dose cohorts (HV range 100-400 mg bid; MDD range 100-600 mg bid). HVs (n = 36) and patients with MDD (n = 54) were dosed under similarly controlled conditions in an inpatient facility, HVs for up to 14 days and MDD patients for up to 28 days. Safety, tolerability, and pharmacokinetics were assessed frequently. Despite comparable pharmacokinetic profiles, the maximum tolerated dose (MTD) in depressed patients was 450 mg bid, twice the MTD established in HVs. No clinically relevant safety issues associated with Org 26576 were noted. This article presents safety, tolerability, and pharmacokinetic data from two different populations examined under similar dosing conditions. The important implications of such bridging work in phase II dose selection are discussed, as are study

Navigating condom use and HIV status disclosure with partners met online: a qualitative pilot study with gay and bisexual men from Craigslist.org.

PubMed

Grov, Christian; Agyemang, Linda; Ventuneac, Ana; Breslow, Aaron S

2013-02-01

We conducted face-to-face semi-structured interviews with 50 men recruited from the New York City men-seeking-men section of Craigslist.org. Participants discussed their favorite venues for meeting sex partners (n = 28 said the Internet), and we focused on these men's responses to probes regarding decisions around condom use and HIV status disclosure with online partners. A majority indicated they set a priori rules for themselves to always use condoms, and they cited the Internet as their favorite venue in part because it helped them sort for like-minded partners. Participants indicated that having in-person conversations around condom use and HIV was often difficult, and that the Internet was a convenient medium to facilitate the process. Notable differences were observed in how HIV-positive and HIV-negative men navigated serostatus disclosure-HIV-negative men were less subtle in starting the conversation. Finally, participants described a common narrative around distrust with online partners, which is one reason why they consistently use condoms. These data suggest that features which allow men to easily indicate, and filter for, condom use preferences should be built into (or maintained on) profile-based sexual networking sites and sexual bulletin board sites.

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Institute CCD School Videos Student Projects Two Eyes, 3D Variable Star Astronomy H-R Diagram Plotting CHOICE Online Institute CCD School Videos Student Projects Two Eyes, 3D Variable Star Astronomy H-R

Partnership at Drugfree.org

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... Local Alliance Access Community Education Resources Host a Film Screening View & Share PSAs Volunteer with Us Become ... Resources to Help Your Community Host a Community Film Screening How We’re Doing: 2016 Project Report ...

Pollinator Partnership | Pollinator.org

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about us Pollinator Partnership's mission is to promote the health of pollinators, critical to food and three bites of food. They also sustain our ecosystems and produce our natural resources by helping plants reproduce. Without the actions of pollinators agricultural economies, our food supply, and

Helping Seniors Plan for Posthospital Discharge Needs Before a Hospitalization Occurs: Results from the Randomized Control Trial of PlanYourLifespan.org.

PubMed

Lindquist, Lee A; Ramirez-Zohfeld, Vanessa; Sunkara, Priya D; Forcucci, Chris; Campbell, Dianne S; Mitzen, Phyllis; Ciolino, Jody D; Kricke, Gayle; Seltzer, Anne; Ramirez, Ana V; Cameron, Kenzie A

2017-11-01

Investigate the effect of PlanYourLifespan.org (PYL) on knowledge of posthospital discharge options. Multisite randomized controlled trial. Nonhospitalized adults, aged =65 years, living in urban, suburban, and rural areas of Texas, Illinois, and Indiana. PYL is a national, publicly available tool that provides education on posthospital therapy choices and local home-based resources. Participants completed an in-person baseline survey, followed by exposure to intervention or attention control (AC) websites, then 1-month and 3-month telephone surveys. The primary knowledge outcome was measured with 6 items (possible 0-6 points) pertaining to hospital discharge needs. Among 385 participants randomized, mean age was 71.9 years (standard deviation 5.6) and 79.5% of participants were female. At 1 month, the intervention group had a 0.6 point change (standard deviation = 1.6) versus the AC group who had a -0.1 point change in knowledge score. Linear mixed modeling results suggest sex, health literacy level, level of education, income, and history of high blood pressure/kidney disease were significant predictors of knowledge over time. Controlling for these variables, treatment effect remained significant (P < 0.0001). Seniors who used PYL demonstrated an increased understanding of posthospitalization and home services compared to the control group. © 2017 Society of Hospital Medicine

Characteristics of value-based health and social care from organisations’ perspectives (OrgValue): a mixed-methods study protocol

PubMed Central

Ansmann, Lena; Hillen, Hendrik Ansgar; Kuntz, Ludwig; Stock, Stephanie; Vennedey, Vera; Hower, Kira Isabelle

2018-01-01

Introduction Health and social care systems are under pressure to organise care around patients’ needs with constrained resources. Several studies reveal that care is constantly challenged by balancing economic requirements against individual patients’ preferences and needs. Therefore, value-based health and social care aims to facilitate patient-centredness while taking the resources spent into consideration. The OrgValue project examines the implementation of patient-centredness while considering the health and social care organisations’ resource orientation in the model region of the city of Cologne, Germany. Methods and analysis First, the implementation status of patient-centredness as well as its facilitators and barriers—also in terms of resource orientation—will be assessed through face-to-face interviews with decision-makers (at least n=18) from health and social care organisations (HSCOs) in Cologne. Second, patients’ understanding of patient-centredness and their preferences and needs will be revealed by conducting face-to-face interviews (at least n=15). Third, the qualitative results will provide the basis for a quantitative survey of decision-makers from all HSCOs in Cologne, which will include questions on patient-centredness, resource orientation and determinants of implementation. Fourth, qualitative interviews with decision-makers from different types of HSCOs will be conducted to develop a uniform measurement instrument on the cost and service structure of HSCOs. Ethics and dissemination For all collected data, the relevant data protection regulations will be adhered to. Consultation and a positive vote from the ethics committee of the Medical Faculty of the University of Cologne have been obtained. All personal identifiers (eg, name, date of birth) will be pseudonymised. Dissemination strategies include a feedback report as well as research and development workshops for the organisations with the aim of initiating organisational

www.common-metrics.org: a web application to estimate scores from different patient-reported outcome measures on a common scale.

PubMed

Fischer, H Felix; Rose, Matthias

2016-10-19

Recently, a growing number of Item-Response Theory (IRT) models has been published, which allow estimation of a common latent variable from data derived by different Patient Reported Outcomes (PROs). When using data from different PROs, direct estimation of the latent variable has some advantages over the use of sum score conversion tables. It requires substantial proficiency in the field of psychometrics to fit such models using contemporary IRT software. We developed a web application ( http://www.common-metrics.org ), which allows estimation of latent variable scores more easily using IRT models calibrating different measures on instrument independent scales. Currently, the application allows estimation using six different IRT models for Depression, Anxiety, and Physical Function. Based on published item parameters, users of the application can directly estimate latent trait estimates using expected a posteriori (EAP) for sum scores as well as for specific response patterns, Bayes modal (MAP), Weighted likelihood estimation (WLE) and Maximum likelihood (ML) methods and under three different prior distributions. The obtained estimates can be downloaded and analyzed using standard statistical software. This application enhances the usability of IRT modeling for researchers by allowing comparison of the latent trait estimates over different PROs, such as the Patient Health Questionnaire Depression (PHQ-9) and Anxiety (GAD-7) scales, the Center of Epidemiologic Studies Depression Scale (CES-D), the Beck Depression Inventory (BDI), PROMIS Anxiety and Depression Short Forms and others. Advantages of this approach include comparability of data derived with different measures and tolerance against missing values. The validity of the underlying models needs to be investigated in the future.

Usage of the www.2aida.org AIDA diabetes software Website: a pilot study.

PubMed

Lehmann, Eldon D

2003-01-01

AIDA is a diabetes-computing program freely available from www.2aida.org on the Web. The software is intended to serve as an educational support tool, and can be used by anyone who has an interest in diabetes, whether they be patients, relatives, health-care professionals, or students. In previous "Diabetes Information Technology & WebWatch" columns various indicators of usage of the AIDA program have been reviewed, and various comments from users of the software have been documented. One aspect of AIDA, though, that has been of considerable interest has been to investigate its Web-based distribution as a wider paradigm for more general medically related usage of the Internet. In this respect we have been keen to understand in general terms: (1) why people are turning to the Web for health-care/diabetes information; (2) more specifically, what sort of people are making use of the AIDA software; and (3) what benefits they feel might accrue from using the program. To answer these types of questions we have been conducting a series of audits/surveys via the AIDA Website, and via the software program itself, to learn as much as possible about who the AIDA end users really are. The rationale for this work is that, in this way, it should be possible to improve the program as well as tailor future versions of the software to the interests and needs of its users. However, a recurring observation is that data collection is easiest if it is as unobtrusive and innocuous as possible. One aspect of learning as much as possible about diabetes Website visitors and users may be to apply techniques that do not necessitate any visitor or user interaction. There are various programs that can monitor what pages visitors are viewing at a site. As these programs do not require visitors to do anything special, over time some interesting insights into Website usage may be obtained. For the current study we have reviewed anonymous logstats data, which are automatically collected at many

Chroni - an Android Application for Geochronologists to Access Archived Sample Analyses from the NSF-Funded Geochron.Org Data Repository.

NASA Astrophysics Data System (ADS)

Nettles, J. J.; Bowring, J. F.

2014-12-01

NSF requires data management plans as part of funding proposals and geochronologists, among other scientists, are archiving their data and results to the public cloud archives managed by the NSF-funded Integrated Earth Data Applications, or IEDA. GeoChron is a database for geochronology housed within IEDA. The software application U-Pb_Redux developed at the Cyber Infrastructure Research and Development Lab for the Earth Sciences (CIRDLES.org) at the College of Charleston provides seamless connectivity to GeoChron for uranium-lead (U-Pb) geochronologists to automatically upload and retrieve their data and results. U-Pb_Redux also manages publication-quality documents including report tables and graphs. CHRONI is a lightweight mobile application for Android devices that provides easy access to these archived data and results. With CHRONI, U-Pb geochronologists can view archived data and analyses downloaded from the Geochron database, or any other location, in a customizable format. CHRONI uses the same extensible markup language (XML) schema and documents used by U-Pb_Redux and GeoChron. Report Settings are special XML files that can be customized in U-Pb_Redux, stored in the cloud, and then accessed and used in CHRONI to create the same customized data display on the mobile device. In addition to providing geologists effortless and mobile access to archived data and analyses, CHRONI allows users to manage their GeoChron credentials, quickly download private and public files via a specified IEDA International Geo Sample Number (IGSN) or URL, and view specialized graphics associated with particular IGSNs. Future versions of CHRONI will be developed to support iOS compatible devices. CHRONI is an open source project under the Apache 2 license and is hosted at https://github.com/CIRDLES/CHRONI. We encourage community participation in its continued development.

Characteristics of value-based health and social care from organisations' perspectives (OrgValue): a mixed-methods study protocol.

PubMed

Ansmann, Lena; Hillen, Hendrik Ansgar; Kuntz, Ludwig; Stock, Stephanie; Vennedey, Vera; Hower, Kira Isabelle

2018-04-27

Health and social care systems are under pressure to organise care around patients' needs with constrained resources. Several studies reveal that care is constantly challenged by balancing economic requirements against individual patients' preferences and needs. Therefore, value-based health and social care aims to facilitate patient-centredness while taking the resources spent into consideration. The OrgValue project examines the implementation of patient-centredness while considering the health and social care organisations' resource orientation in the model region of the city of Cologne, Germany. First, the implementation status of patient-centredness as well as its facilitators and barriers-also in terms of resource orientation-will be assessed through face-to-face interviews with decision-makers (at least n=18) from health and social care organisations (HSCOs) in Cologne. Second, patients' understanding of patient-centredness and their preferences and needs will be revealed by conducting face-to-face interviews (at least n=15). Third, the qualitative results will provide the basis for a quantitative survey of decision-makers from all HSCOs in Cologne, which will include questions on patient-centredness, resource orientation and determinants of implementation. Fourth, qualitative interviews with decision-makers from different types of HSCOs will be conducted to develop a uniform measurement instrument on the cost and service structure of HSCOs. For all collected data, the relevant data protection regulations will be adhered to. Consultation and a positive vote from the ethics committee of the Medical Faculty of the University of Cologne have been obtained. All personal identifiers (eg, name, date of birth) will be pseudonymised. Dissemination strategies include a feedback report as well as research and development workshops for the organisations with the aim of initiating organisational learning and organisational development, presenting results in publications

HealthMpowerment.org: Feasibility and Acceptability of Delivering an Internet Intervention to Young Black Men Who have Sex with Men

PubMed Central

Hightow-Weidman, Lisa B; Pike, Emily; Fowler, Beth; Matthews, Derrick M; Kibe, Jessica; McCoy, Regina; Adimora, Adaora A

2012-01-01

Young Black men who have sex with men (BMSM) are disproportionately affected by HIV/AIDS in the United States and continue to experience rapidly increasing HIV incidence. We designed a tailored, theory-based interactive HIV/STI prevention website for young BMSM, called HealthMpowerment.org (HMP) and conducted a small pilot trial comparing HMP to currently available HIV/STI websites. We present findings demonstrating feasibility and acceptability of delivering the intervention to the target population of young BMSM. Retention rates were 90% and 78% at one and three month follow-ups, respectively. Evaluation immediately after the intervention’s completion revealed that participants who used the HMP website reported high levels of user satisfaction and interest and low levels of website difficulty and frustration. At the end of the intervention, there was a trend in increased behavioral intentions to use condoms and engage in preparatory condom use behaviors in the intervention group compared to the control group (p=.10). We observed a reduction in mean scores on the CES-D scale among those in the intervention group that was not seen in the control group at the one-month follow-up, though this was not statistically significant. Feedback from exit interviews with study participants suggested that HMP is relevant to the prevention needs of young BMSM. Overall, the findings support the acceptability and feasibility of delivering this prevention program to a group that has few interventions despite bearing a significant burden of the epidemic. Future trials, combining internet and mobile phone technologies, are planned to test HMP among larger and more diverse populations of young BMSM. PMID:22272759

Can We Build an Open-Science Model to Fund Young, Risky, Blue-Sky Research? First Insights into Funding Geoscientists Via Thinkable.Org

NASA Astrophysics Data System (ADS)

McNeil, B.

2014-12-01

Some of the biggest discoveries and advances in geoscience research have come from purely curiosity-driven, blue-sky research. Marine biologist Osamu Shimomura's discovery of Green-Fluorecent Protein (GFP) in the 1960s during his postdoc is just one example, which came about through his interest and pursuit of how certain jellyfish bioluminescence. His discovery would eventually revolutionise medicine, culminating in a Nobel Prize in Chemistry in 2008. Despite the known importance of "blue-sky" research that doesn't have immediate commercial or social applications, it continues to struggle for funding from both government and industry. Success rates for young scientists also continue to decline within the government competitive granting models due to the importance of track records, yet history tells us that young scientists tend to come up with science's greatest discoveries. The digital age however, gives us a new opportunity to create an alternative and sustainable funding model for young, risky, blue-sky science that tends not to be supported by governments and industry anymore. Here I will discuss how new digital platforms empower researchers and organisations to showcase their research using video, allowing wider community engagment and funding that can be used to directly support young, risky, blue-sky research that is so important to the future of science. I will then talk about recent experience with this model from some ocean researchers who used a new platform called thinkable.org to showcase and raise funding via the public.

Visual Observing Manual | aavso.org

Science.gov Websites

Institute CCD School Videos Student Projects Two Eyes, 3D Variable Star Astronomy H-R Diagram Plotting Student Projects Two Eyes, 3D Variable Star Astronomy H-R Diagram Plotting Activity Reporting Variable

GMRI.org | Science. Education. Community.

Science.gov Websites

Coastal Communities Science Education Fisheries Convening Events Calendar Event Series Sustainable Seafood Literacy Supporting Sustainable Seafood Strengthening Coastal Communities Our Work Science Education | Cultivating Science Literacy | Supporting Sustainable Seafood | Strengthening Coastal Communities GMRI's

Using the AIDA--www.2aida.org--diabetes simulator. Part 2: recommended training requirements for health-carers planning to teach with the software.

PubMed

Lehmann, Eldon D; Tatti, Patrizio

2002-01-01

The purpose of this article is to document some recommended training requirements for health-carers planning to teach using the AIDA interactive educational diabetes simulator. AIDA is a diabetes computer program that permits the interactive simulation of plasma insulin and blood glucose profiles for teaching, demonstration, and self-learning purposes. It has been made freely available, without charge, on the Internet as a noncommercial contribution to continuing diabetes education. Since its launch in 1996 over 200,000 visits have been logged at the AIDA Website--www.2aida.org--and over 40,000 copies of the AIDA program have been downloaded free-of-charge. This report describes various training requirements that are recommended for health-care professionals who are interested in teaching with the software. Intended goals of this article are to answer possible questions from teachers using the program, highlight some minimum recommended training requirements for the software, suggest some "hints and tips" for teaching ideas, explain the importance of performing more studies/trials with the program, overview randomised controlled trial usage of the software, and highlight the importance of obtaining feedback from lesson participants. The recommendations seem to be straightforward and should help in formalising training with the program, as well as in the development of a network of teachers "accredited" to give lessons using the software. This report, together with the previous article (Part 1, Diabetes Technol Ther 2002;4:401-414), highlights the utility of providing guidelines and suggesting recommended training requirements for health-carers planning to make use of educational medical/diabetes software.

Analysis of AntarcticGlaciers.org: a website used to communicate glaciology by an academic (Invited)

NASA Astrophysics Data System (ADS)

Davies, B. J.

2013-12-01

Research into polar science is driven by humanity's pressing concerns about environmental issues and climate change. The effective communication of this science is vital for it to realise its societal and political relevance. However, effective science communication has proved challenging for many reasons, including biased media presentation, lack of time and funds, lack of training, fear of attack by denialists, and poor career credit given for outreach and education work. A key question is how time-poor researchers, whilst working in full-time academic positions, can implement effective outreach strategies with little budget and few resources, that satisfies not only their personal desire to publicise and communicate their work, but also the demands of their research funder. Science websites and blogs offer one possibility, but there is little critical evaluation as to their effectiveness. The aim of this work is to evaluate a website and social medial tools written by an academic that was established to communicate peer-reviewed science. The goal of www.AntarcticGlaciers.org is to communicate key scientific concepts and to deliver new research findings via a professional, attractive, website and blog, supported by a strong social media presence. The objectives were to 1) to clearly explain and illustrate key concepts in glaciology as well as the latest developments in Antarctic research; 2) to be well aligned with national school curriculums, and to support school and university learning; 3) to include interactive features and social networking tools to encourage engagement and discourse; 4) to be aware of and well aligned with the website's intended audience. One year after website launch, the website was evaluated using a combination of an online feedback form, Google Analytics and analysis of Twitter followers. Our analysis shows that just one year after launch the website is a useful information resource, with some aspects that do challenge the knowledge

The treatable intellectual disability APP www.treatable-id.org: a digital tool to enhance diagnosis & care for rare diseases.

PubMed

van Karnebeek, Clara D M; Houben, Roderick F A; Lafek, Mirafe; Giannasi, Wynona; Stockler, Sylvia

2012-07-23

Intellectual disability (ID) is a devastating and frequent condition, affecting 2-3% of the population worldwide. Early recognition of treatable underlying conditions drastically improves health outcomes and decreases burdens to patients, families and society. Our systematic literature review identified 81 such inborn errors of metabolism, which present with ID as a prominent feature and are amenable to causal therapy. The WebAPP translates this knowledge of rare diseases into a diagnostic tool and information portal. Freely available as a WebAPP via http://www.treatable-id.org and end 2012 via the APP store, this diagnostic tool is designed for all specialists evaluating children with global delay / ID and laboratory scientists. Information on the 81 diseases is presented in different ways with search functions: 15 biochemical categories, neurologic and non-neurologic signs & symptoms, diagnostic investigations (metabolic screening tests in blood and urine identify 65% of all IEM), therapies & effects on primary (IQ/developmental quotient) and secondary outcomes, and available evidence For each rare condition a 'disease page' serves as an information portal with online access to specific genetics, biochemistry, phenotype, diagnostic tests and therapeutic options. As new knowledge and evidence is gained from expert input and PubMed searches this tool will be continually updated. The WebAPP is an integral part of a protocol prioritizing treatability in the work-up of every child with global delay / ID. A 3-year funded study will enable an evaluation of its effectiveness. For rare diseases, a field for which financial and scientific resources are particularly scarce, knowledge translation challenges are abundant. With this WebAPP technology is capitalized to raise awareness for rare treatable diseases and their common presenting clinical feature of ID, with the potential to improve health outcomes. This innovative digital tool is designed to motivate health care

The treatable intellectual disability APP www.treatable-id.org: A digital tool to enhance diagnosis & care for rare diseases

PubMed Central

2012-01-01

Background Intellectual disability (ID) is a devastating and frequent condition, affecting 2-3% of the population worldwide. Early recognition of treatable underlying conditions drastically improves health outcomes and decreases burdens to patients, families and society. Our systematic literature review identified 81 such inborn errors of metabolism, which present with ID as a prominent feature and are amenable to causal therapy. The WebAPP translates this knowledge of rare diseases into a diagnostic tool and information portal. Methods & results Freely available as a WebAPP via http://www.treatable-id.org and end 2012 via the APP store, this diagnostic tool is designed for all specialists evaluating children with global delay / ID and laboratory scientists. Information on the 81 diseases is presented in different ways with search functions: 15 biochemical categories, neurologic and non-neurologic signs & symptoms, diagnostic investigations (metabolic screening tests in blood and urine identify 65% of all IEM), therapies & effects on primary (IQ/developmental quotient) and secondary outcomes, and available evidence For each rare condition a ‘disease page’ serves as an information portal with online access to specific genetics, biochemistry, phenotype, diagnostic tests and therapeutic options. As new knowledge and evidence is gained from expert input and PubMed searches this tool will be continually updated. The WebAPP is an integral part of a protocol prioritizing treatability in the work-up of every child with global delay / ID. A 3-year funded study will enable an evaluation of its effectiveness. Conclusions For rare diseases, a field for which financial and scientific resources are particularly scarce, knowledge translation challenges are abundant. With this WebAPP technology is capitalized to raise awareness for rare treatable diseases and their common presenting clinical feature of ID, with the potential to improve health outcomes. This innovative digital

ATTITUDES ABOUT AND HIV RISK RELATED TO THE “MOST COMMON PLACE” MSM MEET THEIR SEX PARTNERS: COMPARING MEN FROM BATHHOUSES, BARS/CLUBS, AND CRAIGSLIST.ORG

PubMed Central

Grov, Christian; Crow, Thomas

2018-01-01

This study examined attitudes toward the most common place where men who have sex with men (MSM) met their recent male sex partners. In 2009–2010, MSM were surveyed in bars/clubs, bathhouses, and on Craigslist.org. We found strong but differential overlap between venue of recruitment and participants’ most common place: 81% of men from Craigslist indicated their most common place was the Internet, 65% of men from bathhouses indicated their most common place was bathhouses, and 47% of men from bars/clubs indicated their most common place was bars/clubs. In general, interest in seeing more information on drugs/alcohol and HIV and interacting with a health outreach worker in participants’ most common place ranged from “agree” to “strongly agree.” However, men whose most common place was bars/clubs rated these items lowest on average. Rates of unprotected anal intercourse (UAI) were high (43%), thus targeted efforts in bars/clubs, bathhouses, and on the Internet may be ideal venues for reaching high-risk MSM. Although most common place was unrelated to UAI, it was related to factors that contextualize men’s encounters (e.g., attitudes toward HIV status disclosure, and perceptions about barebacking, anonymous sex, and alcohol use). Outreach providers should consider these contextualizing aspects as they continue to retool their efforts. PMID:22468972

Kardex Quadrangle Overlays - www.arlis.org

Science.gov Websites

Wild & Scenic Rivers About Contacts Partner Libraries Policies Administrative Records Challenged Records Challenged Materials Circulation Code of Conduct Conference Room Conference Room Form Internet Use /AK/AE-03/003. This page links to records in jpg graphics format. The images in this collection are

'heartfailurematters.org', an educational website for patients and carers from the Heart Failure Association of the European Society of Cardiology: objectives, use and future directions.

PubMed

Wagenaar, Kim P; Rutten, Frans H; Klompstra, Leonie; Bhana, Yusuf; Sieverink, Floor; Ruschitzka, Frank; Seferovic, Petar M; Lainscak, Mitja; Piepoli, Massimo F; Broekhuizen, Berna D L; Strömberg, Anna; Jaarsma, Tiny; Hoes, Arno W; Dickstein, Kenneth

2017-11-01

In 2007, the Heart Failure Association of the European Society of Cardiology (ESC) launched the information website heartfailurematters.org (HFM site) with the aim of creating a practical tool through which to provide advice and guidelines for living with heart failure to patients, their carers, health care professionals and the general public worldwide. The website is managed by the ESC at the European Heart House and is currently available in nine languages. The aim of this study is to describe the background, objectives, use, lessons learned and future directions of the HFM site. Data on the number of visitor sessions on the site as measured by Google Analytics were used to explore use of the HFM site from 2010 to 2015. Worldwide, the annual number of sessions increased from 416 345 in 2010 to 1 636 368 in 2015. Most users (72-75%) found the site by using a search engine. Desktops and, more recently, smartphones were used to visit the website, accounting for 50% and 38%, respectively, of visits to the site in 2015. Although its use has increased, the HFM site has not yet reached its full potential: fewer than 2 million users have visited the website, whereas the number of people living with heart failure worldwide is estimated to be 23 million. Uptake and use could be further improved by a continuous process of qualitative assessment of users' preferences, and the provision of professional helpdesk facilities, comprehensive information technology, and promotional support. © 2017 The Authors. European Journal of Heart Failure © 2017 European Society of Cardiology.

Combined experimental and Monte Carlo verification of org/images/0031-9155/43/12/008/img1.gif"/> brachytherapy plans for vaginal applicators

NASA Astrophysics Data System (ADS)

Sloboda, Ron S.; Wang, Ruqing

1998-12-01

Dose rates in a phantom around a shielded and an unshielded vaginal applicator containing Selectron low-dose-rate org/images/0031-9155/43/12/008/img2.gif" ALIGN="TOP"/> sources were determined by experiment and Monte Carlo simulation. Measurements were performed with thermoluminescent dosimeters in a white polystyrene phantom using an experimental protocol geared for precision. Calculations for the same set-up were done using a version of the EGS4 Monte Carlo code system modified for brachytherapy applications into which a new combinatorial geometry package developed by Bielajew was recently incorporated. Measured dose rates agree with Monte Carlo estimates to within 5% (1 SD) for the unshielded applicator, while highlighting some experimental uncertainties for the shielded applicator. Monte Carlo calculations were also done to determine a value for the effective transmission of the shield required for clinical treatment planning, and to estimate the dose rate in water at points in axial and sagittal planes transecting the shielded applicator. Comparison with dose rates generated by the planning system indicates that agreement is better than 5% (1 SD) at most positions. The precision thermoluminescent dosimetry protocol and modified Monte Carlo code are effective complementary tools for brachytherapy applicator dosimetry.

Achieving HIV risk reduction through HealthMpowerment.org, a user-driven eHealth intervention for young Black men who have sex with men and transgender women who have sex with men

PubMed Central

Muessig, Kathryn E.; Baltierra, Nina B.; Pike, Emily C.; LeGrand, Sara; Hightow-Weidman, Lisa B.

2014-01-01

Young, Black men who have sex with men and transgender women who have sex with men (YBMSM/TW) are at disproportionate risk for HIV and other sexually transmitted infections (HIV/STI). HealthMpowerment.org (HMP) is a mobile phone optimised online intervention that utilises behaviour change and gaming theories to reduce risky sexual behaviours and build community among HIV-positive and negative YBMSM/TW. The intervention is user-driven, provides social support, and utilises a point reward system. A four-week pilot trial was conducted with a diverse group of 15 YBMSM/TW. During exit interviews, participants described how HMP components led to behaviour changes such as asking partners' sexual history, increased condom use, and HIV/STI testing. The user-driven structure, interactivity, and rewards appeared to facilitate sustained user engagement and the mobile platform provided relevant information in real-time. Participants described the reward elements of exceeding their previous scores and earning points toward prizes as highly motivating. HMP showed promise for being able to deliver a sufficient intervention dose and we found a trend toward higher dose received and more advanced stages of behaviour change. In this pilot trial, HMP was well accepted and demonstrates promise for translating virtual intervention engagement into actual behaviour change to reduce HIV risk behaviours. PMID:25593616

Achieving HIV risk reduction through HealthMpowerment.org, a user-driven eHealth intervention for young Black men who have sex with men and transgender women who have sex with men.

PubMed

Muessig, Kathryn E; Baltierra, Nina B; Pike, Emily C; LeGrand, Sara; Hightow-Weidman, Lisa B

Young, Black men who have sex with men and transgender women who have sex with men (YBMSM/TW) are at disproportionate risk for HIV and other sexually transmitted infections (HIV/STI). HealthMpowerment.org (HMP) is a mobile phone optimised online intervention that utilises behaviour change and gaming theories to reduce risky sexual behaviours and build community among HIV-positive and negative YBMSM/TW. The intervention is user-driven, provides social support, and utilises a point reward system. A four-week pilot trial was conducted with a diverse group of 15 YBMSM/TW. During exit interviews, participants described how HMP components led to behaviour changes such as asking partners' sexual history, increased condom use, and HIV/STI testing. The user-driven structure, interactivity, and rewards appeared to facilitate sustained user engagement and the mobile platform provided relevant information in real-time. Participants described the reward elements of exceeding their previous scores and earning points toward prizes as highly motivating. HMP showed promise for being able to deliver a sufficient intervention dose and we found a trend toward higher dose received and more advanced stages of behaviour change. In this pilot trial, HMP was well accepted and demonstrates promise for translating virtual intervention engagement into actual behaviour change to reduce HIV risk behaviours.

Driver Performance and Behavior in Adverse Weather Conditions: An Investigation Using the SHRP2 Naturalistic Driving Study Data—Phase 2

DOT National Transportation Integrated Search

2018-02-01

Ahmed (orcid.org/0000-0002-1921-0724); Ghasemzadeh (orcid.org/0000-0003-1232-251X); Hammit (orcid.org/0000-0002-8859-9075); Khan (orcid.org/0000-0001-5996-091X); Das (orcid.org/0000-0003-4674-5334); Ali (orcid.org/0000-0001-7643-7143); Eldeeb (orcid....

American Association of Physics Teachers - AAPT.org

Science.gov Websites

Memorial Lecture, and the 2018 J. D. Jackson Award Nov 01 2017 Barbara L. Whitten will be the recipient of ) announced today that the 2017 Paul Zitzewitz Excellence in K-12 Physics Teaching Award winner is J. Mark State University - Marion in honoring the life of professor, Dr. Gordon J. Aubrecht, II. Read more Â

Effectiveness of an interactive platform, and the ESC/HFA heartfailurematters.org website in patients with heart failure: design of the multicentre randomized e-Vita heart failure trial.

PubMed

Wagenaar, Kim P; Broekhuizen, Berna D L; Dickstein, Kenneth; Jaarsma, Tiny; Hoes, Arno W; Rutten, Frans H

2015-12-01

Electronic health support (e-health) may improve self-care of patients with heart failure (HF). We aim to assess whether an adjusted care pathway with replacement of routine consultations by e-health improves self-care as compared with usual care. In addition, we will determine whether the ESC/HFA (European Society of Cardiology/Heart Failure Association) website heartfailurematters.org (HFM website) improves self-care when added to usual care. Finally, we aim to evaluate the cost-effectiveness of these interventions. A three-arm parallel randomized trial will be conducted. Arm 1 consists of usual care; arm 2 consists of usual care plus the HFM website; and arm 3 is the adjusted care pathway with an interactive platform for disease management (e-Vita platform), with a link to the HFM website, which replaces routine consultations with HF nurses at the outpatient clinic. In total, 414 patients managed in 10 Dutch HF outpatient clinics or in general practice will be included and followed for 12 months. Participants are included if they have had an established diagnosis of HF for at least 3 months. The primary outcome is self-care as measured by the European Heart Failure Self-care Behaviour scale (EHFScB scale). Secondary outcomes are quality of life, cardiovascular- and HF-related mortality, hospitalization, and its duration as captured by hospital and general practitioner registries, use of and user satisfaction with the HFM website, and cost-effectiveness. This study will provide important prospective data on the impact and cost-effectiveness of an interactive platform for disease management and the HFM website. unique identifier: NCT01755988. © 2015 The Authors European Journal of Heart Failure © 2015 European Society of Cardiology.

Evaluation of Rural Intersection Treatments

DOT National Transportation Integrated Search

2018-05-01

Shauna Hallmark (orcid.org/0000-0001-5187-8022); Jevan James (orcid.org/0000-0003-1198-4909); Skylar Knickerbocker (orcid.org/0000-0002-0202-5872); Neal Hawkins (orcid.org/0000-0003-0618-6275); Raju Thapa (orcid.org/0000-0002-1930-0535); and Theresa ...

Installation Guidance for Centerline and Edgeline Rumble Strips in Narrow Pavements

DOT National Transportation Integrated Search

2017-09-01

Peter T. Savolainen (orcid.org/0000-0001-5767-9104); Anuj Sharma (orcid.org/0000-0001-5929-5120); Timothy P. Barrette (orcid.org/0000-0002- 7656-3454); Bijan Vafaei (orcid.org/0000-0002-9362-399X); and Trevor J. Kirsch (orcid.org/0000-0002-8163-1570)...

Calibrating Crash Modification Factors for Wyoming-Specific Conditions : Application of the Highway Safety Manual - Part D

DOT National Transportation Integrated Search

2017-04-01

Mohamed Ahmed, Ph.D., P.E.- orcid.org/0000-0002-1921-0724; Sherif Gaweesh, M.S. - orcid.org/0000-0001-7977-6378; Md Julfiker Hossain -orcid.org/0000-0001-7173-7040; Sadia Sharmin orcid.org/0000-0003-0947-8345; Thomas Peel orcid.org/ 0000-0002...

Loading and fate of particulate organic carbon from the Himalaya to the Ganga Brahmaputra delta

NASA Astrophysics Data System (ADS)

Galy, Valier; France-Lanord, Christian; Lartiges, Bruno

2008-04-01

We use the evolution of river sediment characteristics and sedimentary C org from the Himalayan range to the delta to study the transport of C org in the Ganga-Brahmaputra system and especially its fate during floodplain transit. A detailed characterisation of both mineral and organic particles for a sampling set of river sediments allows taking into account the sediment heterogeneity characteristic of such large rivers. We study the relationships between sediment characteristics (mineralogy, grain size, specific area) and C org content in order to evaluate the controls on C org loading. Contributions of C3 and C4 plants are estimated from C org stable isotopic composition (δ 13C org). We use the evolution of δ 13C org values from the Himalayan range to the delta in order to study the fate of C org during floodplain transit. Ganga and Brahmaputra sediments define two distinct linear relations with specific area. In spite of 4-5 times higher specific area, Ganga sediments have similar C org content, grain size and mineralogy as Brahmaputra sediments, indicating that specific area does not exert a primary control on C org loading. The general correlation between the total C org content and Al/Si ratio indicates that C org loading is mainly related to: (1) segregation of organic particles under hydrodynamic forces in the river, and (2) the ability of mineral particles to form organo-mineral aggregates. Bed and suspended sediments have distinct δ 13C org values. In bed sediments, δ 13C org values are compatible with a dominant proportion of fossil C org derived from Himalayan rocks erosion. Suspended sediments from Himalayan tributaries at the outflow of the range have low δ 13C org values (-24.8‰ average) indicating a dominant proportion of C3 plant inputs. In the Brahmaputra basin, δ 13C org values of suspended sediments are constant along the river course in the plain. On the contrary, suspended sediments of the Ganga in Bangladesh have higher δ 13C org

Seagrass blue carbon dynamics in the Gulf of Mexico: Stocks, losses from anthropogenic disturbance, and gains through seagrass restoration.

PubMed

Thorhaug, Anitra; Poulos, Helen M; López-Portillo, Jorge; Ku, Timothy C W; Berlyn, Graeme P

2017-12-15

Seagrasses comprise a substantive North American and Caribbean Sea blue carbon sink. Yet fine-scale estimates of seagrass carbon stocks, fluxes from anthropogenic disturbances, and potential gains in sedimentary carbon from seagrass restoration are lacking for most of the Western Hemisphere. To begin to fill this knowledge gap in the subtropics and tropics, we quantified organic carbon (C org ) stocks, losses, and gains from restorations at 8 previously-disturbed seagrass sites around the Gulf of Mexico (GoM) (n=128 cores). Mean natural seagrass C org stocks were 25.7±6.7MgC org ha -1 around the GoM, while mean C org stocks at adjacent barren sites that had previously hosted seagrass were 17.8MgC org ha -1 . Restored seagrass beds contained a mean of 38.7±13.1MgC org ha -1 . Mean C org losses differed by anthropogenic impact type, but averaged 20.98±7.14MgC org ha -1 . C org gains from seagrass restoration averaged 20.96±8.59Mgha -1 . These results, when combined with the similarity between natural and restored C org content, highlight the potential of seagrass restoration for mitigating seagrass C org losses from prior impact events. Our GoM basin-wide estimates of natural C org totaled ~36.4Tg for the 947,327ha for the USA-GoM. Including Mexico, the total basin contained an estimated 37.2-37.5Tg C org . Regional US-GoM losses totaled 21.69Tg C org . C org losses differed significantly among anthropogenic impacts. Yet, seagrass restoration appears to be an important climate change mitigation strategy that could be implemented elsewhere throughout the tropics and subtropics. Copyright © 2017 Elsevier B.V. All rights reserved.

Global Application of the Assessment of Communication Skills of Paediatric Endocrinology Fellows in the Management of Differences in Sex Development Using the ESPE E-Learning.Org Portal.

PubMed

Kranenburg, Laura J C; Reerds, Sam T H; Cools, Martine; Alderson, Julie; Muscarella, Miriam; Magrite, Ellie; Kuiper, Martijn; Abdelgaffar, Shereen; Balsamo, Antonio; Brauner, Raja; Chanoine, Jean Pierre; Deeb, Asma; Fechner, Patricia; German, Alina; Holterhus, Paul Martin; Juul, Anders; Mendonca, Berenice B; Neville, Kristen; Nordenstrom, Anna; Oostdijk, Wilma; Rey, Rodolfo A; Rutter, Meilan M; Shah, Nalini; Luo, Xiaoping; Grijpink, Kalinka; Drop, Stenvert L S

2017-01-01

Information sharing in chronic conditions such as disorders of/differences in sex development (DSD) is essential for a comprehensive understanding by parents and patients. We report on a qualitative analysis of communication skills of fellows undergoing training in paediatric endocrinology. Guidelines are created for the assessment of communication between health professionals and individuals with DSD and their parents. Paediatric endocrinology fellows worldwide were invited to study two interactive online cases (www.espe-elearning.org) and to describe a best practice communication with (i) the parents of a newborn with congenital adrenal hyperplasia and (ii) a young woman with 46,XY gonadal dysgenesis. The replies were analysed regarding completeness, quality, and evidence of empathy. Guidelines for structured assessment of responses were developed by 22 senior paediatric endocrinologists worldwide who assessed 10 selected replies. Consensus of assessors was established and the evaluation guidelines were created. The replies of the fellows showed considerable variation in completeness, quality of wording, and evidence of empathy. Many relevant aspects of competent clinical communication were not mentioned; 15% (case 1) and 17% (case 2) of the replies were considered poor/insufficient. There was also marked variation between 17 senior experts in the application of the guidelines to assess communication skills. The guidelines were then adjusted to a 3-level assessment with empathy as a separate key item to better reflect the qualitative differences in the replies and for simplicity of use by evaluators. E-learning can play an important role in assessing communication skills. A practical tool is provided to assess how information is shared with patients with DSD and their families and should be refined by all stakeholders, notably interdisciplinary health professionals and patient representatives. © 2017 S. Karger AG, Basel.

How Do Beta Blocker Drugs Affect Exercise?

MedlinePlus

... for Heart.org CPR & ECC for Heart.org Shop for Heart.org Causes for Heart.org Advocate ... Thromboembolism Aortic Aneurysm More How do beta blocker drugs affect exercise? Updated:Aug 22,2017 Beta blockers ...

Fahr's Syndrome

MedlinePlus

... 55 Kenosia Avenue Danbury CT Danbury, CT 06810 orphan@rarediseases.org http://rarediseases.org Tel: 203-744- ... 55 Kenosia Avenue Danbury CT Danbury, CT 06810 orphan@rarediseases.org http://rarediseases.org Tel: 203-744- ...

About Peripheral Artery Disease (PAD)

MedlinePlus

... for Heart.org CPR & ECC for Heart.org Shop for Heart.org Causes for Heart.org Advocate ... grow large enough to significantly reduce the blood's flow through an artery. When a plaque becomes brittle ...

Neuroleptic Malignant Syndrome

MedlinePlus

... 55 Kenosia Avenue Danbury CT Danbury, CT 06810 orphan@rarediseases.org http://rarediseases.org Tel: 203-744- ... 55 Kenosia Avenue Danbury CT Danbury, CT 06810 orphan@rarediseases.org http://rarediseases.org Tel: 203-744- ...

Medication Interactions: Food, Supplements and Other Drugs

MedlinePlus

... for Heart.org CPR & ECC for Heart.org Shop for Heart.org Causes for Heart.org Advocate ... Aneurysm More Medication Interactions: Food, Supplements and Other Drugs Updated:Oct 15,2014 Some foods — even healthy ...

Protect Yourself against Hepatitis A and B: A Guide for Gay and Bisexual Men

MedlinePlus

... vaccineinformation.org www.immunize.org/catg.d/p4115.pdf • Item #P4115 (5/18) Protect Yourself Against Hepatitis ... vaccineinformation. org www. immunize. org/ catg. d/ p4115. pdf • Item #P4115 (5/18)

47 CFR 80.1061 - Special requirements for 406.0-406.1 MHz EPIRB stations.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., VA 22209, www.rtcm.org, e-mail at [email protected]org. (b) The 406.0-406.1 EPIRB must contain as an... Kingdom, Telephone: +44 20-7728 1391, Facsimile: +44 20-7728 1170; www.cospas-sarsat.org. The RTCM... St., Suite 1060, Arlington, VA 22209, http://www.rtcm.org, e-mail at [email protected]org. (1) After a 406.0...

Improving estimates of real-time traffic speeds during weather for winter maintenance performance measurements.

DOT National Transportation Integrated Search

2017-04-01

Vianey Leos Barajas (orcid.org/0000-0001-8016-773X), Zhonglei Wang (orcid.org/0000-0001-6712-0750), Mark Kaiser (orcid.org/0000-0003-0449-0388), and Zhengyuan Zhu (orcid.org/0000-0002-2266-0646) : This report describes two related projects, the secon...

Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment.

PubMed

Xu, Tianhua; Sheng, Zitong; Yao, Li

2017-09-01

In light of the rapid increase in the number of obesity incidences worldwide, obesity has become an independent risk factor for chronic kidney disease. Obesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions. IgM and complement 3 (C3) nonspecifically deposit in lesions without immune-complex-type deposits during ORG immunofluorescence. ORG-associated glomerulomegaly and focal and segmental glomerulosclerosis can superimpose on other renal pathologies. The mechanisms under ORG are complex, especially hemodynamic changes, inflammation, oxidative stress, apoptosis, and reduced functioning nephrons. These mechanisms synergize with obesity to induce end-stage renal disease. A slow increase of subnephrotic proteinuria ( < 3.5 g/d) is the most common clinical manifestation of ORG. Several treatment methods for ORG have been developed. Of these methods, renin-angiotensin-aldosterone system blockade and weight loss are proven effective. Targeting mitochondria may offer a novel strategy for ORG therapy. Nevertheless, more research is needed to further understand ORG.

Southern Appalachian Man and the Biosphere - SAMAB.ORG

Science.gov Websites

Southern Appalachian Man and the Biosphere Home Who We Are SAMAB Initiatives Archives Welcome to SAMAB This slideshow requires JavaScript. The Southern Appalachian Man and the Biosphere (SAMAB

ResearchMaps.org for integrating and planning research.

PubMed

Matiasz, Nicholas J; Wood, Justin; Doshi, Pranay; Speier, William; Beckemeyer, Barry; Wang, Wei; Hsu, William; Silva, Alcino J

2018-01-01

To plan experiments, a biologist needs to evaluate a growing set of empirical findings and hypothetical assertions from diverse fields that use increasingly complex techniques. To address this problem, we operationalized principles (e.g., convergence and consistency) that biologists use to test causal relations and evaluate experimental evidence. With the framework we derived, we then created a free, open-source web application that allows biologists to create research maps, graph-based representations of empirical evidence and hypothetical assertions found in research articles, reviews, and other sources. With our ResearchMaps web application, biologists can systematically reason through the research that is most important to them, as well as evaluate and plan experiments with a breadth and precision that are unlikely without such a tool.

Places to Go: Sakai|http://www.sakaiproject.org/

ERIC Educational Resources Information Center

Downes, Stephen

2006-01-01

Stephen Downes continues his examination of open source learning management systems (LMSs) with a visit to Sakai's Web site. While Sakai's Web site is not particularly easy to navigate, it provides access to a large community and constellation of related online learning products and initiatives. Visitors can visit discussion forums to ask…

ResearchMaps.org for integrating and planning research

PubMed Central

Speier, William; Beckemeyer, Barry; Wang, Wei; Hsu, William; Silva, Alcino J.

2018-01-01

To plan experiments, a biologist needs to evaluate a growing set of empirical findings and hypothetical assertions from diverse fields that use increasingly complex techniques. To address this problem, we operationalized principles (e.g., convergence and consistency) that biologists use to test causal relations and evaluate experimental evidence. With the framework we derived, we then created a free, open-source web application that allows biologists to create research maps, graph-based representations of empirical evidence and hypothetical assertions found in research articles, reviews, and other sources. With our ResearchMaps web application, biologists can systematically reason through the research that is most important to them, as well as evaluate and plan experiments with a breadth and precision that are unlikely without such a tool. PMID:29723213

Wallops Island natural rain data analysis

NASA Technical Reports Server (NTRS)

Wang, TING-I.

1994-01-01

ScTI has performed a detailed analysis of four optical rain gauge ORG-105 sensors tested by Wallops Island on 8 May 1992. The four ORG's tested were S/N 2236, 2237, 2239, and 2241. Shown is a 30 minute time series of the individual ORG's, the ORG average, and the weighing gauge. The sensors tracked well with rainrates (RR) up to 45 mm/hr for the period. Also shown is a plot of accumulated rainfall over the same period. It can be seen that even though the ORG's tracked well, some ORG's tended to read higher and some read lower during the event.

Air Force’s Combat Aircraft: A Future Holding into the Past

DTIC Science & Technology

2010-04-07

Global Security, “9M111 / SA-19 GRISON ,” Globalsecurity.org, http://www.globalsecurity.org/military/world/ russia/sa-19.htm (accessed March 13, 2010...world/russia/9k338.htm (assessed March 13, 2010). Global Security. “9M111 / SA-19 GRISON .” Globalsecurity.org. http://www.globalsecurity. org

Coalition Network Defence Common Operational Picture

DTIC Science & Technology

2010-11-01

27000 .org/ iso -27005.htm [26] ISO 8601:2004, Data elements and interchange formats - Information interchange - Representation of dates and times, http://ww.iso.org, http://en.wikipedia.org/wiki/ISO_8601 ...Regular_expression [25] ISO /IEC 27005:2008, Information technology -- Security techniques -- Information security risk management, http://ww.iso.org,; http://www

Carbon burial and storage in tropical salt marshes under the influence of sea level rise.

PubMed

Ruiz-Fernández, A C; Carnero-Bravo, V; Sanchez-Cabeza, J A; Pérez-Bernal, L H; Amaya-Monterrosa, O A; Bojórquez-Sánchez, S; López-Mendoza, P G; Cardoso-Mohedano, J G; Dunbar, R B; Mucciarone, D A; Marmolejo-Rodríguez, A J

2018-07-15

Coastal vegetated habitats can be important sinks of organic carbon (C org ) and mitigate global warming by sequestering significant quantities of atmospheric CO 2 and storing sedimentary C org for long periods, although their C org burial and storage capacity may be affected by on-going sea level rise and human intervention. Geochemical data from published 210 Pb-dated sediment cores, collected from low-energy microtidal coastal wetlands in El Salvador (Jiquilisco Bay) and in Mexico (Salada Lagoon; Estero de Urias Lagoon; Sian Ka'an Biosphere Reserve) were revisited to assess temporal changes (within the last 100years) of C org concentrations, storage and burial rates in tropical salt marshes under the influence of sea level rise and contrasting anthropization degree. Grain size distribution was used to identify hydrodynamic changes, and δ 13 C to distinguish terrigenous sediments from those accumulated under the influence of marine transgression. Although the accretion rate ranges in all sediment records were comparable, C org concentrations (0.2-30%), stocks (30-465Mgha -1 , by extrapolation to 1m depth), and burial rates (3-378gm -2 year -1 ) varied widely within and among the study areas. However, in most sites sea level rise decreased C org concentrations and stocks in sediments, but increased C org burial rates. Lower C org concentrations were attributed to the input of reworked marine particles, which contribute with a lower amount of C org than terrigenous sediments; whereas higher C org burial rates were driven by higher mass accumulation rates, influenced by increased flooding and human interventions in the surroundings. C org accumulation and long-term preservation in tropical salt marshes can be as high as in mangrove or temperate salt marsh areas and, besides the reduction of C org stocks by ongoing sea level rise, the disturbance of the long-term buried C org inventories might cause high CO 2 releases, for which they must be protected as a part of

Impact of Organic and Conventional Systems of Coffee Farming on Soil Properties and Culturable Microbial Diversity

PubMed Central

2016-01-01

A study was undertaken with an objective of evaluating the long-term impacts of organic (ORG) and conventional (CON) methods of coffee farming on soil physical, chemical, biological, and microbial diversity. Electrical conductivity and bulk density were found to increase by 34% and 21%, respectively, in CON compared to ORG system, while water holding capacity was found decreased in both the systems. Significant increase in organic carbon was observed in ORG system. Major nutrients, nitrogen and potassium, levels showed inclination in both ORG and CON system, but the trend was much more pronounced in CON system. Phosphorus was found to increase in both ORG and CON system, but its availability was found to be more with CON system. In biological attributes, higher soil respiration and fluorescein diacetate activity were recorded in ORG system compared to CON system. Higher soil urease activity was observed in CON system, while dehydrogenase activity does not show significant differences between ORG and CON systems. ORG system was found to have higher macrofauna (31.4%), microbial population (34%), and microbial diversity indices compared to CON system. From the present study, it is accomplished that coffee soil under long-term ORG system has better soil properties compared to CON system. PMID:27042378

Impact of Organic and Conventional Systems of Coffee Farming on Soil Properties and Culturable Microbial Diversity.

PubMed

Velmourougane, Kulandaivelu

2016-01-01

A study was undertaken with an objective of evaluating the long-term impacts of organic (ORG) and conventional (CON) methods of coffee farming on soil physical, chemical, biological, and microbial diversity. Electrical conductivity and bulk density were found to increase by 34% and 21%, respectively, in CON compared to ORG system, while water holding capacity was found decreased in both the systems. Significant increase in organic carbon was observed in ORG system. Major nutrients, nitrogen and potassium, levels showed inclination in both ORG and CON system, but the trend was much more pronounced in CON system. Phosphorus was found to increase in both ORG and CON system, but its availability was found to be more with CON system. In biological attributes, higher soil respiration and fluorescein diacetate activity were recorded in ORG system compared to CON system. Higher soil urease activity was observed in CON system, while dehydrogenase activity does not show significant differences between ORG and CON systems. ORG system was found to have higher macrofauna (31.4%), microbial population (34%), and microbial diversity indices compared to CON system. From the present study, it is accomplished that coffee soil under long-term ORG system has better soil properties compared to CON system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tomopy is a Python toolbox to perform x-ray data processing, image reconstruction and data exchange tasks at synchrotron facilities. The dependencies of the software are currently as follows: -Python related python standard library (http://docs.python.org/2/library/) numpy (http://www.numpy.org/) scipy (http://scipy.org/) matplotlib (http://matplotlip.org/) sphinx (http://sphinx-doc.org) pil (http://www.pythonware.com/products/pil/) pyhdf (http://pysclint.sourceforge.net/pyhdf/) h5py (http://www.h5py.org) pywt (http://www.pybytes.com/pywavelets/) file.py (https://pyspec.svn.sourceforge.net/svnroot/pyspec/trunk/pyspec/ccd/files.py) -C/C++ related: gridec (anonymous?? C-code written back in 1997 that uses standard C library) fftw (http://www.fftw.org/) tomoRecon (multi-threaded C++ verion of gridrec. Author: Mark Rivers from APS. http://cars9.uchicago.edu/software/epics/tomoRecon.html) epics (http://www.aps.anl.gov/epics/)

Study the Antinociceptive Effect of Intracerebroventricular Injection of Aqueous Extract of Origanum Vulgare Leaves in Rat: Possible Involvement of Opioid System

PubMed Central

Pahlavan, Yasaman; Sepehri, Gholamreza; Sheibani, Vahid; Afarinesh khaki, Mohammadreza; Gojazadeh, Morteza; Pahlavan, Bahare; Pahlavan, Fereshteh

2013-01-01

Objective(s): The aim of study was to investigate the antinociceptive effect of intracerebroventricular (ICV) microinjection of Origanum vulgare (ORG) extract and possible involvement of opioid receptors. Materials and Methods: Cannula was inserted into left ventricle of male rats. Five days after surgery Tail Flick Latency (TFL) was measured after ICV microinjection of, ORG (1, 3 and 6 µg / rat). Effective dose of ORG was injected ICV in concomitant with morphine (2 mg/kg, IP), naloxone (2 mg / kg, IP) and saline (0.5 µl/rat) and TFL was recorded. Results: The co- administration of ORG extract with morphine showed a significant increase in TFL and naloxone, pretreatment significantly inhibited the antinociceptive activity of ORG and morphine. Conclusion: The aqueous extract of ORG possesses antinociceptive activities in the tail-flick test in a dose dependent manner. ORG - induced antinociception may have been mediated by opioid systems. PMID:24379969

Facing Neurofibromatosis: A Guide for Teens

MedlinePlus

... Clinic information NF clinic contact____________________________ Phone ____________________________________ Email _____________________________________ Support groups • Children’s Tumor Foundation: ctf.org • NF Network: nfmidwest.org and nfnetwork.org Children’s Hospital of ...

Mineral composition of pulp and production of the yellow passion fruit with organic and conventional fertilizers.

PubMed

Pacheco, Anália Lúcia Vieira; Pagliarini, Mateus Francisco; de Freitas, Gilberto Bernardo; Santos, Ricardo Henrique Silva; Serrão, José Eduardo; Zanuncio, José Cola

2017-02-15

The use of organic foods has been increased in the world. Organic fertilizers, like cattle manure, have emerged as an important component of the organic system production. The production, mass, size, and mineral composition of passion fruit pulp were evaluated when treated with a mineral fertilizer (control) (MIN) or cattle manure at a single dose equivalent to potassium fertilizer (ORG) or double dose (2×ORG). The production and the numbers of fruits of plants treated with MIN and 2×ORG was higher than with ORG. The level of nitrogen (N), phosphorus (P), zinc (Zn), iron (Fe), and copper (Cu) in the fruit pulp was similar with all three fertilizers, but the calcium (Ca) and magnesium (Mg) was higher with ORG and 2×ORG. The number and weight of the fruits of passion fruit treated with 2×ORG were similar to those with MIN fertilizer, but they contained more Ca and Mg. Copyright © 2016 Elsevier Ltd. All rights reserved.

Extension modules for storage, visualization and querying of genomic, genetic and breeding data in Tripal databases

PubMed Central

Lee, Taein; Cheng, Chun-Huai; Ficklin, Stephen; Yu, Jing; Humann, Jodi; Main, Dorrie

2017-01-01

Abstract Tripal is an open-source database platform primarily used for development of genomic, genetic and breeding databases. We report here on the release of the Chado Loader, Chado Data Display and Chado Search modules to extend the functionality of the core Tripal modules. These new extension modules provide additional tools for (1) data loading, (2) customized visualization and (3) advanced search functions for supported data types such as organism, marker, QTL/Mendelian Trait Loci, germplasm, map, project, phenotype, genotype and their respective metadata. The Chado Loader module provides data collection templates in Excel with defined metadata and data loaders with front end forms. The Chado Data Display module contains tools to visualize each data type and the metadata which can be used as is or customized as desired. The Chado Search module provides search and download functionality for the supported data types. Also included are the tools to visualize map and species summary. The use of materialized views in the Chado Search module enables better performance as well as flexibility of data modeling in Chado, allowing existing Tripal databases with different metadata types to utilize the module. These Tripal Extension modules are implemented in the Genome Database for Rosaceae (rosaceae.org), CottonGen (cottongen.org), Citrus Genome Database (citrusgenomedb.org), Genome Database for Vaccinium (vaccinium.org) and the Cool Season Food Legume Database (coolseasonfoodlegume.org). Database URL: https://www.citrusgenomedb.org/, https://www.coolseasonfoodlegume.org/, https://www.cottongen.org/, https://www.rosaceae.org/, https://www.vaccinium.org/

Research use of the AIDA www.2aida.org diabetes software simulation program: a review--part 2. Generating simulated blood glucose data for prototype validation.

PubMed

Lehmann, Eldon D

2003-01-01

The purpose of this review is to describe research applications of the AIDA diabetes software simulator. AIDA is a computer program that permits the interactive simulation of insulin and glucose profiles for teaching, demonstration, and self-learning purposes. Since March/April 1996 it has been made freely available on the Internet as a noncommercial contribution to continuing diabetes education. Up to May 2003 well over 320,000 visits have been logged at the main AIDA Website--www.2aida.org--and over 65,000 copies of the AIDA program have been downloaded free-of-charge. This review (the second of two parts) overviews research projects and ventures, undertaken for the most part by other research workers in the diabetes computing field, that have made use of the freeware AIDA program. As with Part 1 of the review (Diabetes Technol Ther 2003;5:425-438) relevant research work was identified in three main ways: (i) by personal (e-mail/written) communications from researchers, (ii) via the ISI Web of Science citation database to identify published articles which referred to AIDA-related papers, and (iii) via searches on the Internet. Also, in a number of cases research students who had sought advice about AIDA, and diabetes computing in general, provided copies of their research dissertations/theses upon the completion of their projects. Part 2 of this review highlights some more of the research projects that have made use of the AIDA diabetes simulation program to date. A wide variety of diabetes computing topics are addressed. These range from learning about parameter interactions using simulated blood glucose data, to considerations of dietary assessments, developing new diabetes models, and performance monitoring of closed-loop insulin delivery devices. Other topics include evaluation/validation research usage of such software, applying simulated blood glucose data for prototype training/validation, and other research uses of placing technical information on the Web

ACHP | Historic Preservation Organizations

Science.gov Websites

www.ahlp.org American Cultural Resources Association www.acra-crm.org American Institute of Architects www.aia.org National Alliance of Preservation Commissions http://napc.uga.edu/ National Association of Tribal

Robotics FAQ Index

Science.gov Websites

faqs.org Robotics FAQ Index faqs.org faqs.org - Internet FAQ Archives Robotics FAQ Index [By Updates | Archive Stats | Search | Help] Internet RFC Index Usenet FAQ Index Other FAQs Documents Tools

Gangliosidoses

MedlinePlus

... Diseases Association 2001 Beacon Street Suite 204 Boston MA Boston, MA 02135 info@ntsad.org http://www.ntsad.org ... Diseases Association 2001 Beacon Street Suite 204 Boston MA Boston, MA 02135 info@ntsad.org http://www. ...

Chronic Pain

MedlinePlus

... 0043 Arthritis Foundation P.O. Box 7669 Atlanta GA Atlanta, GA 30357 help@arthritis.org http://www.arthritis.org ... 0043 Arthritis Foundation P.O. Box 7669 Atlanta GA Atlanta, GA 30357 help@arthritis.org http://www. ...

American Association of Poison Control Centers

MedlinePlus

... all alerts right left NEW! Check out PoisonHelp.org Now there are two ways to get help ... AAPCC's new interactive online poison information tool, PoisonHelp.org. PoisonHelp.org Make your smartphone even smarter. Text " ...

Low Carbon sink capacity of Red Sea mangroves.

PubMed

Almahasheer, Hanan; Serrano, Oscar; Duarte, Carlos M; Arias-Ortiz, Ariane; Masque, Pere; Irigoien, Xabier

2017-08-29

Mangroves forests of Avicennia marina occupy about 135 km 2 in the Red Sea and represent one of the most important vegetated communities in this otherwise arid and oligotrophic region. We assessed the soil organic carbon (C org ) stocks, soil accretion rates (SAR; mm y -1 ) and soil C org sequestration rates (g C org m -2 yr -1 ) in 10 mangrove sites within four locations along the Saudi coast of the Central Red Sea. Soil C org density and stock in Red Sea mangroves were among the lowest reported globally, with an average of 4 ± 0.3 mg C org cm -3 and 43 ± 5 Mg C org ha -1 (in 1 m-thick soils), respectively. Sequestration rates of C org , estimated at 3 ± 1 and 15 ± 1 g C org m -2 yr -1 for the long (millennia) and short (last century) temporal scales, respectively, were also relatively low compared to mangrove habitats from more humid bioregions. In contrast, the accretion rates of Central Red Sea mangroves soils were within the range reported for global mangrove forests. The relatively low C org sink capacity of Red Sea mangroves could be due to the extreme environmental conditions such as low rainfall, nutrient limitation and high temperature, reducing the growth rates of the mangroves and increasing soil respiration rates.

Alzheimer's Disease Information Page

MedlinePlus

... Dementia Association 912 Killian Hill Road, S.W. Lilburn GA Lilburn, GA 30047 lbda@lbda.org http://www.lbda.org ... Dementia Association 912 Killian Hill Road, S.W. Lilburn GA Lilburn, GA 30047 lbda@lbda.org http://www. ...

Hemochromatosis

MedlinePlus

... Fax: 407–333–1284 Email: mail@ americanhs. org Internet: www. americanhs. org American Liver Foundation 39 Broadway, ... or 212–668–1000 Fax: 212–483–8179 Internet: www. liverfoundation. org 7 Hemochromatosis Iron Disorders Institute ...

Utilizing the Elements of National Power to Predict Ungoverned Space

DTIC Science & Technology

2007-05-07

3Globalsecurity.org, Where are the Legions? [ SPQR ] Global Deployments of US Forces, Available from http://www.globalsecurity.org/military/ops/global...NY: Cornell University Press, 2004. Globalsecurity.org. Where Are the Legions? [ SPQR ] Global Depoyments of US Forces. Available from http

User Manual for IDA Reading Guide Website Visitors

DTIC Science & Technology

2012-01-01

modules. The most important module is called Biblio , which enables the display of bibliographic information. Other modules of special importance are... Biblio : http://drupal.org/project/ biblio • Apache Solr: http://drupal.org/project/apachesolr • Glossary: http://drupal.org/project/glossary

Estimating Energy Efficiency of Connected and Autonomous Vehicles in a Mixed Fleet

DOT National Transportation Integrated Search

2018-05-01

Jing Dong (orcid.org/0000-0002-7304-8430); Liang Hu (orcid.org/0000-0001-6351-8542); Chaoru Lu (orcid.org/0000-0001-8418-7658); Connected and autonomous vehicle (CAV) technologies are likely to be gradually implemented over time and in a traffic envi...

10 CFR 431.75 - Materials incorporated by reference.

Code of Federal Regulations, 2010 CFR

2010-01-01

...-Conditioning Engineers, Inc., 1971 Tullie Circle, NE., Atlanta, GA 30329, or http://www.ashrae.org/book..., CO 80112, or http://global.ihs.com/, or http://webstore.ansi.org/ansidocstore/. (iii) The UL Standard... 07922, or http://www.gamanet.org/publist/hydroordr.htm. ...

SR22 Insurance Cost, Quotes and Rates - Stopimpaireddriving.org

Science.gov Websites

? Those who meet one or more of the following characteristics may be required to obtain SR22 coverage: One who has been convicted of driving while under the influence of alcohol or drugs (DUI); One who has been convicted of driving while intoxicated (DUI); One who has been driving with a suspended or revoked

Flutrack.org: Open-source and linked data for epidemiology.

PubMed

Chorianopoulos, Konstantinos; Talvis, Karolos

2016-12-01

Epidemiology has made advances, thanks to the availability of real-time surveillance data and by leveraging the geographic analysis of incidents. There are many health information systems that visualize the symptoms of influenza-like illness on a digital map, which is suitable for end-users, but it does not afford further processing and analysis. Existing systems have emphasized the collection, analysis, and visualization of surveillance data, but they have neglected a modular and interoperable design that integrates high-resolution geo-location with real-time data. As a remedy, we have built an open-source project and we have been operating an open service that detects flu-related symptoms and shares the data in real-time with anyone who wants to built upon this system. An analysis of a small number of precisely geo-located status updates (e.g. Twitter) correlates closely with the Google Flu Trends and the Centers for Disease Control and Prevention flu-positive reports. We suggest that public health information systems should embrace an open-source approach and offer linked data, in order to facilitate the development of an ecosystem of applications and services, and in order to be transparent to the general public interest. © The Author(s) 2015.

Phytophthora-ID.org: A sequence-based Phytophthora identification tool

Treesearch

N.J. Grünwald; F.N. Martin; M.M. Larsen; C.M. Sullivan; C.M. Press; M.D. Coffey; E.M. Hansen; J.L. Parke

2010-01-01

Contemporary species identification relies strongly on sequence-based identification, yet resources for identification of many fungal and oomycete pathogens are rare. We developed two web-based, searchable databases for rapid identification of Phytophthora spp. based on sequencing of the internal transcribed spacer (ITS) or the cytochrome oxidase...

75 FR 27625 - Announcement of the Fall 2010 Annual Grant Competition Effective October 1, 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-17

... resolution. Deadline: October 1, 2010. Online application available: http://www.usip.org/[email protected]org . FOR FURTHER INFORMATION CONTACT: The Grant Program, Annual Grant Competition, Phone (202) 429-3842, email: [email protected]org . Dated: May 11, 2010. Michael Graham, Vice President for Management...

A hybrid two-component system protein from Azospirillum brasilense Sp7 was involved in chemotaxis.

PubMed

Cui, Yanhua; Tu, Ran; Wu, Lixian; Hong, Yuanyuan; Chen, Sanfeng

2011-09-20

We here report the sequence and functional analysis of org35 of Azospirillum brasilense Sp7, which was originally identified to be able to interact with NifA in yeast-two-hybrid system. The org35 encodes a hybrid two-component system protein, including N-terminal PAS domains, a histidine kinase (HPK) domain and a response regulator (RR) domain in C-terminal. To determine the function of the Org35, a deletion-insertion mutant in PAS domain [named Sp7353] and a complemental strain Sp7353C were constructed. The mutant had reduced chemotaxis ability compared to that of wild-type, and the complemental strain was similar to the wild-type strain. These data suggested that the A. brasilense org35 played a key role in chemotaxis. Variants containing different domains of the org35 were expressed, and the functions of these domains were studied in vitro. Phosphorylation assays in vitro demonstrated that the HPK domain of Org35 possessed the autokinase activity and that the phosphorylated HPK was able to transfer phosphate groups to the RR domain. The result indicated Org35 was a phosphorylation-communicating protein. Copyright © 2010 Elsevier GmbH. All rights reserved.

Can salt on an optical rain gauge lens affect performance?

NASA Technical Reports Server (NTRS)

Bliven, Larry F.

1994-01-01

The optical rain gauge (ORG) by ScTI is designed to be tolerant to reduction of infrared beam intensity due to a dirty lens. Recently there is interest in long term use of optical gauges onboard buoys at sea. Because of logistics, these systems are serviced infrequently, i.e., every several months. Due to the proximity of the gauges to the sea surface, salt can be expected to be deposited on the lens. To obtain an indication of the potential for dirty lens to affect the ORG calibration, two simple experiments were conducted. In the control experiment, a sample ORG was compared to three other ORG's during natural rain events. Next a translucent mask was placed on the transmitter lens of the sample ORG and again data were collected under natural rain conditions. The mask reduced the gain of the perturbed ORG by about 30%. The perturbed ORG operated rather well in that the mask only causes a change in the gain and does not cause data drop out at low rain rates. However, the reduced gain would seriously impact an assessment of rain statistics.

12 CFR 7.1016 - Independent undertakings to pay against documents.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Publishing, Inc., 212/206-1150; http://www.iccwbo.org); the Supplements to UCP 500 & 600 for Electronic... Electronic Presentation) (available from ICC Publishing, Inc., 212/206-1150; http://www.iccwbo.org... Banking Law & Practice, 301/869-9840; http://www.iiblp.org); the United Nations Convention on Independent...

77 FR 47117 - Chemical, Biological, Radiological, Nuclear (CBRN) Protective Ensemble Standard, Certification...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-07

... (at www.justnet.org ) three draft documents related to Chemical, Biological, Radiological, Nuclear... until September 21, 2012. FOR FURTHER INFORMATION CONTACT: For further information, see www.justnet.org , or contact David Otterson by telephone at 301-519-5498 or by email at [email protected]org...

10 CFR 851.27 - Reference sources.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., NY 10036. Telephone number: 212-642-4980, or go to: http://www.ansi.org. (iv) National Fire....nfpa.org. (v) American Conference of Governmental Industrial Hygienist (ACGIH), 1330 Kemper Meadow Drive, Cincinnati, OH 45240. Telephone number 513-742-2020, or go to: http://www.acgih.org. (vi...

Research use of the AIDA www.2aida.org diabetes software simulation program: a review-part 1. decision support testing and neural network training.

PubMed

Lehmann, Eldon D

2003-01-01

The purpose of this two-part review is to overview research use of the AIDA diabetes software simulator. AIDA is a diabetes computer program that permits the interactive simulation of plasma insulin and blood glucose profiles for teaching, demonstration, and self-learning purposes. It has been made freely available, without charge, on the Internet as a noncommercial contribution to continuing diabetes education. Since its launch in 1996 over 300,000 visits have been logged at the main AIDA Website-www.2aida.org-and over 60,000 copies of the AIDA program have been downloaded free-of-charge. This review describes research projects and ventures, undertaken for the most part by other research workers in the diabetes computing field, that have made use of the freeware AIDA software. Relevant research work was identified in three main ways: (i) by personal (e-mail/written) communications from researchers, (ii) via the ISI Web of Science citation database to identify published articles that referred to AIDA-related papers, and (iii) via searches on the Internet. In a number of cases research students who had sought advice about AIDA, and diabetes computing in general, provided copies of their research dissertations/theses upon the completion of their projects. The two reviews highlight some of the many and varied research projects that have made use of the AIDA diabetes simulation software to date. A wide variety of diabetes computing topics have been addressed. In Part 1 of the review, these range from testing decision support prototypes to training artificial neural networks. In Part 2 of the review, issues surrounding dietary assessments, developing new diabetes models, and performance monitoring of closed-loop insulin delivery devices are considered. Overall, research projects making use of AIDA have been identified in Australia, Italy, South Korea, the United Kingdom, and the United States. These reviews confirm an unexpected but useful benefit of distributing

Driver performance and behavior in adverse weather conditions : an investigation using the SHRP2 naturalistic driving study data--phase 1.

DOT National Transportation Integrated Search

2015-12-01

Mohamed M. Ahmed, Ph.D., P.E. (orcid.org/0000-0002-1921-0724) : Ali Ghasemzadeh, M.Sc. (orcid.org/0000-0003-1232-251X) : Hesham Eldeeb, Ph.D. : Sherif Gaweesh, M.Sc. (orcid.org/0000-0001-7977-6378) : Joshua Clapp, Ph.D. : Khaled Ksaibati, Ph.D., P.E....

76 FR 45577 - Clinical Investigator Training Course

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-29

... course at the registration/ information Web site at https://www.trialstransformation.org/fda-clinical... be made at https://www.supportnlc.org/Room_Reservations.html or by calling 301-431-6400. FDA has... information, and a detailed description of the course can be found at https://www.trialstransformation.org/fda...

75 FR 58465 - U.S. Department of State Advisory Committee on Private International Law: Notice of Annual Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-24

... Choice of Court Agreements, the UNCITRAL E-Commerce and Letter of Credit Conventions, and others... Friday. Time permitting, the discussion is expected to focus on developments in a number of areas, e.g...://www.unidroit.org ; http://www.oas.org , and http://www.nccusl.org . We may, by e-mail, supplement...

30 CFR 75.333 - Ventilation controls.

Code of Federal Regulations, 2010 CFR

2010-07-01

...), 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959; http://www.astm.org. This....astm.org. This incorporation by reference was approved by the Director of the Federal Register in... Conshohocken, PA 19428-2959; http://www.astm.org. This incorporation by reference was approved by the Director...

77 FR 23539 - WTO Dispute Settlement Proceeding Regarding European Communities and Certain Member States...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-19

... Organization (``WTO Agreement''). That request may be found at www.wto.org contained in a document designated....wto.org contained in a document designated as WT/DS316/23. Public Comment: Requirements for... available on the Web site of the World Trade Organization, www.wto.org . Comments open to public inspection...

29 CFR 1918.3 - Incorporation by reference.

Code of Federal Regulations, 2010 CFR

2010-07-01

....org. (5) ANSI Z41-1991, American National Standard for Personal Protection—Protective Footwear; IBR...; Web site: http://www.nsc.org. (6) ANSI Z87.1-2003, American National Standard Practice for...; fax: 703-528-2148; Web site: http://www.safetyequipment.org. (7) ANSI Z87.1-1989 (R-1998), American...

76 FR 9004 - Public Comment on Setting Achievement Levels in Writing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-16

....wested.org/cs/naep/print/docs/naep/welcome.html , describes the process that will produce cutscores to....nagb.org Public and private individuals and organizations are invited to provide written comments and... the review and comment, the following materials are posted at http://www.wested.org/cs/naep/print/docs...

75 FR 6688 - Section 8 Housing Assistance Payments Program-Renewal Funding Annual Adjustment Factors, Fiscal...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... were published in a separate notice which can be viewed at: http://www.huduser.org/portal/datasets/aaf... be available electronically from the HUD data information page at http://www.huduser.org/portal... overview and in the FMR documentation at http://www.HUDUSER.org . In this publication, the rent and utility...

78 FR 28291 - Announcement of the Fall 2013 Annual Grant Competition for Immediate Release

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-14

... resolution. Deadline: October 1, 2013; Online application available: http://www.usip.org/grants-fellowships... 20037, (202) 429-3842 (phone), (202) 833-1018 (fax), (202) 457-1719 (TTY), Email: [email protected]org . FOR...: [email protected]org . Dated: May 8, 2013. Michael Graham, Senior Vice President for Management. [FR Doc. 2013...

75 FR 27625 - Announcement of the Priority Grant Competition for Immediate Release

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-17

... specific themes for each priority area may be found at our Web site at: http://www.usip.org/grants....usip.org/grants-fellowships/priority-grant-competition for specific information on the competition as...) (202) 457-1719 (TTY) E-mail: [email protected]org . FOR FURTHER INFORMATION CONTACT: The Grant Program...

47 CFR 15.38 - Incorporation by reference.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., 25 West 43rd Street, 4th Floor, New York, NY 10036 or at http://webstore.ansi.org/ansidocstore/default.asp; or Society of Cable Telecommunications Engineers at http://www.scte.org/standards/index.cfm...: Consumer Electronics Association, 2500 Wilson Blvd., Arlington, VA 22201 or at http://www.ce.org...

Diverse behaviors of outer radial glia in developing ferret and human cortex.

PubMed

Gertz, Caitlyn C; Lui, Jan H; LaMonica, Bridget E; Wang, Xiaoqun; Kriegstein, Arnold R

2014-02-12

The dramatic increase in neocortical size and folding during mammalian brain evolution has been attributed to the elaboration of the subventricular zone (SVZ) and the associated increase in neural progenitors. However, recent studies have shown that SVZ size and the abundance of resident progenitors do not directly predict cortical topography, suggesting that complex behaviors of the progenitors themselves may contribute to the overall size and shape of the adult cortex. Using time-lapse imaging, we examined the dynamic behaviors of SVZ progenitors in the ferret, a gyrencephalic carnivore, focusing our analysis on outer radial glial cells (oRGs). We identified a substantial population of oRGs by marker expression and their unique mode of division, termed mitotic somal translocation (MST). Ferret oRGs exhibited diverse behaviors in terms of division location, cleavage angle, and MST distance, as well as fiber orientation and dynamics. We then examined the human fetal cortex and found that a subset of human oRGs displayed similar characteristics, suggesting that diversity in oRG behavior may be a general feature. Similar to the human, ferret oRGs underwent multiple rounds of self-renewing divisions but were more likely to undergo symmetric divisions that expanded the oRG population, as opposed to producing intermediate progenitor cells (IPCs). Differences in oRG behaviors, including proliferative potential and daughter cell fates, may contribute to variations in cortical structure between mammalian species.

The International Atomic Energy Agency’s Decision to Find Iran in Non-Compliance, 2002-2006

DTIC Science & Technology

2012-12-01

Programme,” Mehr News Agency, November 14, 2004, avail- able at <www.iaea.org/newscenter/focus/iaeairan/eu_iran14112004.shtml>. 59 Shannon N. Kile , ed...www.iaea.org/newscenter/focus/iaeairan/eu_ iran14112004.shtml>. 61 Kile , 67. 62 IAEA Board Resolution, November 29, 2004, available at <www.iaea.org

78 FR 28292 - Announcement of the Priority Grant Competition For Immediate Release

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-14

... area may be found at our Web site at: http://www.usip.org/grants-fellowships/priority-grant-competition... announced throughout the year. Please visit our Web site at: http://www.usip.org/grants-fellowships/priority..., (202) 429-3842 (phone), (202) 833-1018 (fax), (202) 457-1719 (TTY), Email: [email protected]org . FOR...

77 FR 33015 - WTO Dispute Settlement Proceeding Regarding India-Measures Concerning the Importation of Certain...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-04

....org contained in a document designated as WT/DS430/2. USTR invites written comments from the public....wto.org contained in a document designated as WT/DS430/1. The United States and India held... Trade Organization, www.wto.org . Comments open to public inspection may be viewed on the www...

20th Annual Systems Engineering Conference. Volume 3, Thursday

DTIC Science & Technology

2017-10-26

Assurance Center (JFAC) 2017 Update u Mr. Thomas Hurt, Department of Defense 4B1 Tr a c k 2 m il le r Education & Training 19813 Shaping the...k s a n d r a M a r k i n a - K h u s i d amk@mitre.org D r. R ya n J a c o b s r j a c o b s @mitre.org October 2017 NDIA 20th Annual Systems...A n t u l lantul@mitre.org D r. A l e k s a n d r a M a r k i n a - K h u s i d amk@mitre.org D r. R y a n J a c o b s rjacobs@mitre.org J a

Ecological landscape elements: long-term monitoring in Great Britain, the Countryside Survey 1978-2007 and beyond

NASA Astrophysics Data System (ADS)

Wood, Claire M.; Bunce, Robert G. H.; Norton, Lisa R.; Maskell, Lindsay C.; Smart, Simon M.; Scott, W. Andrew; Henrys, Peter A.; Howard, David C.; Wright, Simon M.; Brown, Michael J.; Scott, Rod J.; Stuart, Rick C.; Watkins, John W.

2018-04-01

The Countryside Survey (CS) of Great Britain (GB) provides a unique and statistically robust series of datasets, consisting of an extensive set of repeated ecological measurements at a national scale, covering a time span of 29 years. CS was first undertaken in 1978 to provide a baseline for ecological and land use change monitoring in the rural environment of GB, following a stratified random design, based on 1 km squares. Originally, eight random 1 km squares were drawn from each of 32 environmental classes, thus comprising 256 sample squares in the 1978 survey. The number of these sites increased to 382 in 1984, 506 in 1990, 569 in 1998 and 591 in 2007. Detailed information regarding vegetation types and land use was mapped in all five surveys, allowing reporting by defined standard habitat classifications. Additionally, point and linear landscape features (such as trees and hedgerows) are available from all surveys after 1978. From these stratified, randomly located sample squares, information can be converted into national estimates, with associated error terms. Other data, relating to soils, freshwater and vegetation, were also sampled on analogous dates. However, the present paper describes only the surveys of landscape features and habitats. The resulting datasets provide a unique, comprehensive, quantitative ecological coverage of extent and change in these features in GB. Basic results are presented and their implications discussed. However, much opportunity for further analyses remains. Data from each of the survey years are available via the following DOIs: Landscape area data 1978: org/10.5285/86c017ba-dc62-46f0-ad13-c862bf31740e" target="_blank">https://doi.org/10.5285/86c017ba-dc62-46f0-ad13-c862bf31740e, 1984: org/10.5285/b656bb43-448d-4b2c-aade-7993aa243ea3" target="_blank">https://doi.org/10.5285/b656bb43-448d-4b2c-aade-7993aa243ea3, 1990: org/10.5285/94f664e5-10f2-4655-bfe6

Mast Cell and M1 Macrophage Infiltration and Local Pro-Inflammatory Factors Were Attenuated with Incretin-Based Therapies in Obesity-Related Glomerulopathy.

PubMed

He, Jiao; Yuan, Geheng; Cheng, Fangxiao; Zhang, Junqing; Guo, Xiaohui

2017-09-01

The global increase of obesity parallels the obesity-related glomerulopathy (ORG) epidemic. Dipeptidyl peptidase 4 inhibitors and glucagon-like peptide-1 receptor agonists were well recognized to attenuate renal injury independent of glucose control in diabetic nephropathy. There are limited studies focusing on their effects on ORG. We explored the effects of incretin-based therapies on early ORG and the inflammatory responses involved mainly concentrated on mast cell (MC) and macrophage (M) infiltration and local pro-inflammatory factors. ORG rat models were induced by high-fat diet and then divided into ORG vehicle, vildagliptin (3 mg/kg/day, qd) and liraglutide (200 μg/kg, bid) treated groups. After 8 weeks of treatments, albuminuria, glomerular histology, renal inflammatory cell infiltration, and pro-inflammatory factors were analyzed. Early ORG model was demonstrated by albuminuria, glomerulomegaly, foot process fusion, and mesangial and endothelial mild proliferation. Incretin-based therapies limited body weight gain and improved insulin sensitivity. ORG was alleviated, manifested by decreased average glomerular area, attenuated mesangial and endothelial cell proliferation, and revived cell-to-cell propagation of podocytes, which contributed to reduced albuminuria. Compared with ORG vehicle, MC and M1 macrophage (pro-inflammatory) infiltration and M1/M2 ratio were significantly decreased; M2 macrophage (anti-inflammatory) was not significantly increased after incretin-based treatments. Tumor necrosis factor-α (TNF-α) and IL-6 in renal cortex were significantly downregulated, while transforming growth factor-β1 (TGF-β1) remained unchanged. Incretin-based treatments could alleviate high-fat diet-induced ORG partly through the systemic insulin sensitivity improvement and the attenuated local inflammation, mainly by the decrease of MC and M1 macrophage infiltration and reduction of TNF-α and IL-6.

45 CFR 170.299 - Incorporation by reference.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., MI 48104; Telephone (734) 677-7777 or http://www.hl7.org/. (1) Health Level Seven Standard Version 2..., PA, 19428-2959 USA; Telephone (610) 832-9585 or http://www.astm.org/. (1) ASTM E2369-05: Standard...) 477-1000; and Facsimile (480) 767-1042 or http://www.ncpdp.org. (1) National Council for Prescription...

24 CFR 100.201a - Incorporation by reference.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., DC 20001-2070, telephone number 1-888-422-7233, http://www.iccsafe.org/e/category.html. (2) American..., DC 20001-2070, telephone number 1-888-422-7233, http://www.iccsafe.org/e/category.html. (3) American..., DC 20001-2070, telephone number 1-888-422-7233, http://www.iccsafe.org/e/category.html. (4) American...

76 FR 12400 - WTO Dispute Settlement Proceeding Regarding China-Countervailing and Anti-Dumping Duties on Grain...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-07

... at http://www.wto.org , in a document designated as WT/DS414/2. USTR invites written comments from....org contained in a document designated as WT/DS414/1. The United States and China held consultations... on the Web site of the World Trade Organization, http://www.wto.org . Comments open to public...

77 FR 2119 - WTO Dispute Settlement Proceeding Regarding China-Anti-Dumping and Countervailing Duty Measures...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-13

... from the United States. That request may be found at www.wto.org contained in a document designated as... requested consultations with China. That request may be found at www.wto.org contained in a document... of the Appellate Body, will be available on the Web site of the World Trade Organization, www.wto.org...

Visualizing and communicating uncertainty in the earth and environmental sciences: a review

NASA Astrophysics Data System (ADS)

Pebesma, Edzer

2014-05-01

I will review past attempts to visualising uncertainty in spatial or spatio-temporal predictions of groundwater quality, quality predictions, sea bed sediment, bird densities, air quality measurements, and exposure to air quality of individuals and populations. The attempts involved software development (aguila [1], greenland [2]), the development of standards for communicating uncertain spatial and spatio-temporal information (UncertML, [3]), and have been illustrated by applications in a number of EU projects (Apmosphere [4], INTAMAP [5], UncertWeb [6] and GeoViQua [7]). I will also report on usability studies that were carried out (e.g. [8]). [1] http://pcraster.geo.uu.nl/projects/developments/aguila/ [2] https://wiki.52north.org/bin/view/Geostatistics/Greenland [3] http://www.uncertml.org/ [4] http://www.apmosphere.org/ [5] http://www.intamap.org/ [6] http://www.uncertweb.org/ [7] http://www.geoviqua.org/ [8] Senaratne, H. L. Gerharz, E. Pebesma, A. Schwering, 2012. Usability of Spatio-Temporal Uncertainty Visualisation Methods. In: Bridging the Geographic Information Sciences, Lecture Notes in Geoinformation and Cartography, J. Gensel, D. Josselin and D. Vandenbroucke. Springer Berlin Heidelberg.

Ocean Drilling Program: Science Operator

Science.gov Websites

: www.odplegacy.org Integrated Ocean Drilling Program (IODP): www.iodp.org IODP U.S. Implementing Organization (IODP -USIO): www.iodp-usio.org The Ocean Drilling Program (ODP) was funded by the U.S. National Science Foundation and 22 international partners (JOIDES) to conduct basic research into the history of the ocean

29 CFR 1917.3 - Incorporation by reference.

Code of Federal Regulations, 2010 CFR

2010-07-01

...: 212-642-4900; fax: 212-398-0023; Web site: http://www.ansi.org. (1) ANSI A14.1-1990, Safety..., Itasca, IL 60143-0558; telephone: 1-800-621-7619; fax: 708-285-0797; Web site: http://www.nsc.org. (5...://www.nsc.org. (6) ANSI Z87.1-2003, American National Standard Practice for Occupational and Educational...

77 FR 69897 - Comment Request for Information Collection for Occupational Code Assignment, Extension Without...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-21

....onetcenter.org/ombclearance.html . DATES: Written comments must be submitted to the office listed in the... information in the O*NET Web sites including O*NET OnLine ( http://online.onetcenter.org ), My Next Move ( www.MyNextMove.gov ) and My Next Move for Veterans ( www.MyNextMove.org/vets ) O*NET Code Connector ( www...

77 FR 61818 - WTO Dispute Settlement Proceeding Regarding United States-Anti-Dumping and Countervailing Duties...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-11

... certain automobiles from the United States. That request may be found at www.wto.org in a document... China. That request may be found at www.wto.org contained in a document designated as WT/DS440/1. The... Organization, www.wto.org . Comments open to public inspection may be viewed on the www.regulations.gov Web...

33 CFR 155.140 - Incorporation by reference.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Standards Institute, Inc. (ANSI), 25 West 43rd Street, New York, NY 10036, 212-642-4980, http://www.ansi.org..., PA 19428-2959, 610-832-9585, http://www.astm.org/: (1) ASTM F 631-93, Standard Guide for Collecting..., London SE1 7SR, United Kingdom, http://www.imo.org/: (1) Resolution A.535(13), Recommendations on...

49 CFR 575.3 - Matter incorporated by reference.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., Switzerland, +41 22 749 01 11, http://www.iso.org/iso/home.htm. All ISO materials are also available from the..., New York, NY 10036-7417, 212-642-4900, http://www.ansi.org/. (1) International Organization for... Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959, 610-832-9500, http://www.astm.org...

33 CFR 154.106 - Incorporation by reference: Where can I get a copy of the publications incorporated by reference...

Code of Federal Regulations, 2010 CFR

2010-07-01

... NW., Washington, DC 20037, 202-682-8000, http://www.api.org/: (1) API Standard 2000, Venting... Institute (ANSI), 11 West 42nd Street, New York, NY 10036, 202-293-8020, http://www.ansi.org: (1) ANSI B16.5... International, 100 Barr Harbor Drive, West Conshohocken, PA 19428-2959, 610-832-9585, http://www.astm.org/: (1...

75 FR 23318 - WTO Dispute Settlement Proceeding Regarding Philippines-Taxes on Distilled Spirits

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-03

... request may be found at http://www.wto.org in a document designated as WT/DS403/4. The panel was...://www.wto.org contained in a document designated as WT/DS403/1. Consultations were held in Geneva on... available on the Web site of the World Trade Organization, http://www.wto.org . Comments will be placed in...

Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments

NASA Astrophysics Data System (ADS)

Stornaiuolo, Mariano; Bruno, Agostino; Botta, Lorenzo; Regina, Giuseppe La; Cosconati, Sandro; Silvestri, Romano; Marinelli, Luciana; Novellino, Ettore

2015-10-01

A Cannabinoid Receptor 1 (CB1) binding site for the selective allosteric modulator ORG27569 is here identified through an integrate approach of consensus pocket prediction, mutagenesis studies and Mass Spectrometry. This unprecedented ORG27569 pocket presents the structural features of a Cholesterol Consensus Motif, a cholesterol interacting region already found in other GPCRs. ORG27569 and cholesterol affects oppositely CB1 affinity for orthosteric ligands. Moreover, the rise in cholesterol intracellular level results in CB1 trafficking to the axonal region of neuronal cells, while, on the contrary, ORG27568 binding induces CB1 enrichment at the soma. This control of receptor migration among functionally different membrane regions of the cell further contributes to downstream signalling and adds a previously unknown mechanism underpinning CB1 modulation by ORG27569 , that goes beyond a mere control of receptor affinity for orthosteric ligands.

Reply to Comment by W. R. Peltier, D. F. Argus, and R. Drummond on "An Assessment of the ICE6G_C (VM5a) Glacial Isostatic Adjustment Model"

NASA Astrophysics Data System (ADS)

Purcell, A.; Tregoning, P.; Dehecq, A.

2018-02-01

The empirical approximation of Purcell et al. (2011, https://doi.org/10.1029/2011GL048624) has been validated by Peltier et al. (2018, https://doi.org/10.1002/2016JB013844). In their Comment they introduced new results derived from the same ice/rheology models of ICE6G_C (VM5a) but using a different model for Antarctic bathymetry. This has greatly reduced the differences in predicted Antarctic uplift rates relative to those of Purcell et al. (2016, https://doi.org/10.1002/2015JB012742). In fact, with a ˜50% reduction in uplift rate in the Weddell Sea, the results of Peltier et al. (2018, https://doi.org/10.1002/2016JB013844) now agree more closely with the predictions of Purcell et al. (2016, https://doi.org/10.1002/2015JB012742) than with the original ICE6G_C values. Peltier et al. (2018, https://doi.org/10.1002/2016JB013844) state that the high power in their high-frequency spherical harmonic coefficients remains in their new calculations. They also claim that Purcell et al. (2016, https://doi.org/10.1002/2015JB012742) used an inaccurate loading history in deriving their velocity field. In fact, the ice load history was unchanged; to remove any ambiguity, the ice and water load histories used in the CALSEA calculations are provided in the supporting information.

Staff - Karri R. Sicard | Alaska Division of Geological & Geophysical

Science.gov Websites

Raw Data File 2017-5, 26 p. http://doi.org/10.14509/29727 Todd, Erin, Kylander-Clark, Andrew, Wypych Geological & Geophysical Surveys Raw Data File 2017-2, 7 p. http://doi.org/10.14509/29717 Wypych, Alicja ; Geophysical Surveys Raw Data File 2016-9, 3 p. http://doi.org/10.14509/29685 Twelker, Evan, Freeman, L.K

31 CFR Appendix B to Chapter V - Alphabetical Listing of Vessels That Are the Property of Blocked Persons or Specially Designated...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Tanker 36,330 HNAZ Iraqi Oil Tankers Company, Basrah, Iraq AL-ALYAA IRAQ Iraq Tug 375 N/A State Org. of Iraqi Ports AL-AMIN IRAQ Iraq Tug 368 YIAM State Org. of Iraqi Ports AL ANBAR IRAQ Iraqi flag Tug YIAV... IRAQ Iraq Tanker 9,928 HNBT Iraqi Oil Tankers Company AL-BAKR IRAQ Iraq Research 390 YIBR State Org. of...

Individual, family, and group therapy for adolescents.

PubMed

McCann, Christina M; le Roux, Pieter

2006-02-01

The three main psychotherapeutic treatment modalities include individual,family, and group therapies. Many theoretic orientations guide psychotherapists as they try to help adolescents with mental health problems. PCPs play a critical role in initial assessment of mental health symptoms, in addition to coordinating treatment needs. There is a need for increased education regarding mental health treatment for health care providers to help them connect adolescents and their families to appropriate mental health care providers. Integrative approaches that involve more than one treatment modality are often needed to provide the best treatment for adolescents. Better collaborative care not only improves physician understanding of mental health treatment but also improves the mental health provider's understanding of the medical system [30]. This emerging con-text of increased mutual collaborative care builds a better system that serves the adolescent.Web-based resources related to psychotherapy for adolescents American Academy of Child and Adolescent Psychiatry http://www.AACAP.org American Association for Marriage & Family Therapy http://www.AAMFT.org American Psychological Association http://www.APA.org American Psychiatric Association http://www.psych.org National Mental Health Association http://www.NMHA.org National Alliance for the Mentally Ill http://www.NAMI.org

Ensembl BioMarts: a hub for data retrieval across taxonomic space.

PubMed

Kinsella, Rhoda J; Kähäri, Andreas; Haider, Syed; Zamora, Jorge; Proctor, Glenn; Spudich, Giulietta; Almeida-King, Jeff; Staines, Daniel; Derwent, Paul; Kerhornou, Arnaud; Kersey, Paul; Flicek, Paul

2011-01-01

For a number of years the BioMart data warehousing system has proven to be a valuable resource for scientists seeking a fast and versatile means of accessing the growing volume of genomic data provided by the Ensembl project. The launch of the Ensembl Genomes project in 2009 complemented the Ensembl project by utilizing the same visualization, interactive and programming tools to provide users with a means for accessing genome data from a further five domains: protists, bacteria, metazoa, plants and fungi. The Ensembl and Ensembl Genomes BioMarts provide a point of access to the high-quality gene annotation, variation data, functional and regulatory annotation and evolutionary relationships from genomes spanning the taxonomic space. This article aims to give a comprehensive overview of the Ensembl and Ensembl Genomes BioMarts as well as some useful examples and a description of current data content and future objectives. Database URLs: http://www.ensembl.org/biomart/martview/; http://metazoa.ensembl.org/biomart/martview/; http://plants.ensembl.org/biomart/martview/; http://protists.ensembl.org/biomart/martview/; http://fungi.ensembl.org/biomart/martview/; http://bacteria.ensembl.org/biomart/martview/.

Menu-driven cloud computing and resource sharing for R and Bioconductor.

PubMed

Bolouri, Hamid; Dulepet, Rajiv; Angerman, Michael

2011-08-15

We report CRdata.org, a cloud-based, free, open-source web server for running analyses and sharing data and R scripts with others. In addition to using the free, public service, CRdata users can launch their own private Amazon Elastic Computing Cloud (EC2) nodes and store private data and scripts on Amazon's Simple Storage Service (S3) with user-controlled access rights. All CRdata services are provided via point-and-click menus. CRdata is open-source and free under the permissive MIT License (opensource.org/licenses/mit-license.php). The source code is in Ruby (ruby-lang.org/en/) and available at: github.com/seerdata/crdata. hbolouri@fhcrc.org.

75 FR 62624 - WTO Dispute Settlement Proceeding Regarding United States-Final Antidumping Measures on Stainless...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-12

... request may be found at http://www.wto.org in document WT/DS344/20. USTR invites written comments from the... in that dispute, which can be found at http://www.wto.org in documents WT/DS344/R and WT/DS344/AB/R...://www.wto.org . Comments will be placed in the docket and open to public inspection pursuant to 15 CFR...

Gastrointestinal disorders - resources

MedlinePlus

Digestive disease - resources; Resources - gastrointestinal disorders ... org American Liver Foundation -- www.liverfoundation.org National Digestive Diseases Information Clearinghouse -- www.niddk.nih.gov/health- ...

Implementing a Community-Driven Cyberinfrastructure Platform for the Paleo- and Rock Magnetic Scientific Fields that Generalizes to Other Geoscience Disciplines

NASA Astrophysics Data System (ADS)

Minnett, R.; Jarboe, N.; Koppers, A. A.; Tauxe, L.; Constable, C.

2013-12-01

EarthRef.org is a geoscience umbrella website for several databases and data and model repository portals. These portals, unified in the mandate to preserve their respective data and promote scientific collaboration in their fields, are also disparate in their schemata. The Magnetics Information Consortium (http://earthref.org/MagIC/) is a grass-roots cyberinfrastructure effort envisioned by the paleo- and rock magnetic scientific community to archive their wealth of peer-reviewed raw data and interpretations from studies on natural and synthetic samples and relies on a partially strict subsumptive hierarchical data model. The Geochemical Earth Reference Model (http://earthref.org/GERM/) portal focuses on the chemical characterization of the Earth and relies on two data schemata: a repository of peer-reviewed reservoir geochemistry, and a database of partition coefficients for rocks, minerals, and elements. The Seamount Biogeosciences Network (http://earthref.org/SBN/) encourages the collaboration between the diverse disciplines involved in seamount research and includes the Seamount Catalog (http://earthref.org/SC/) of bathymetry and morphology. All of these portals also depend on the EarthRef Reference Database (http://earthref.org/ERR/) for publication reference metadata and the EarthRef Digital Archive (http://earthref.org/ERDA/), a generic repository of data objects and their metadata. The development of the new MagIC Search Interface (http://earthref.org/MagIC/search/) centers on a reusable platform designed to be flexible enough for largely heterogeneous datasets and to scale up to datasets with tens of millions of records. The HTML5 web application and Oracle 11g database residing at the San Diego Supercomputer Center (SDSC) support the online contribution and editing of complex datasets in a spreadsheet environment and the browsing and filtering of these contributions in the context of thousands of other datasets. EarthRef.org is in the process of

Magnetic fields from domestic appliances in the UK

NASA Astrophysics Data System (ADS)

Preece, A. W.; Kaune, W.; Grainger, P.; Preece, S.; Golding, J.

1997-01-01

In a survey of 50 UK homes the 50 Hz fundamental and harmonic magnetic fields generated by 806 domestic appliances found in the homes, and used regularly by mothers, were measured. Measurements were made in the direction of most likely access, and from the surface of the appliances. Mothers completed a questionnaire on the use of appliances and were monitored for 24 h so that acquired exposure could be compared with the measured ambient fields in the home. Appliances were measured at standard distances and an algorithm was used to calculate fields at 100 and 50 cm to remove room background contributions. A few appliances generated fields in excess of org/images/0031-9155/42/1/004/img6.gif" ALIGN="TOP"/> at 1 m: microwave cookers org/images/0031-9155/42/1/004/img7.gif" ALIGN="TOP"/>; washing machines org/images/0031-9155/42/1/004/img8.gif" ALIGN="TOP"/>; dishwashers org/images/0031-9155/42/1/004/img9.gif" ALIGN="TOP"/>; some electric showers org/images/0031-9155/42/1/004/img10.gif" ALIGN="TOP"/> and can openers org/images/0031-9155/42/1/004/img11.gif" ALIGN="TOP"/>. Of continuously operating devices, only central heating pumps (org/images/0031-9155/42/1/004/img12.gif" ALIGN="TOP"/>), central heating boilers (org/images/0031-9155/42/1/004/img13.gif" ALIGN="TOP"/>) and fish-tank air pumps (org/images/0031-9155/42/1/004/img14.gif" ALIGN="TOP"/>) produced significant fields at 0.5 m. There were no obvious ways to group different types of appliances as high- or low-strength sources. Mothers spent on average about 4.5 h per day in the kitchen, where the strongest sources of magnetic field were located.

Accuracy of Monte Carlo photon transport simulation in characterizing brachytherapy dosimeter energy-response artefacts

NASA Astrophysics Data System (ADS)

Das, R. K.; Li, Z.; Perera, H.; Williamson, J. F.

1996-06-01

Practical dosimeters in brachytherapy, such as thermoluminescent dosimeters (TLD) and diodes, are usually calibrated against low-energy megavoltage beams. To measure absolute dose rate near a brachytherapy source, it is necessary to establish the energy response of the detector relative to that of the calibration energy. The purpose of this paper is to assess the accuracy of Monte Carlo photon transport (MCPT) simulation in modelling the absolute detector response as a function of detector geometry and photon energy. We have exposed two different sizes of TLD-100 (LiF chips) and p-type silicon diode detectors to calibrated org/images/0031-9155/41/6/004/img1.gif" ALIGN="TOP"/>, HDR source org/images/0031-9155/41/6/004/img2.gif" ALIGN="TOP"/> and superficial x-ray beams. For the Scanditronix electron-field diode, the relative detector response, defined as the measured detector readings per measured unit of air kerma, varied from org/images/0031-9155/41/6/004/img3.gif" ALIGN="TOP"/> (40 kVp beam) to org/images/0031-9155/41/6/004/img4.gif" ALIGN="TOP"/> (org/images/0031-9155/41/6/004/img1.gif" ALIGN="TOP"/> beam). Similarly for the large and small chips the same quantity varied from org/images/0031-9155/41/6/004/img6.gif" ALIGN="TOP"/> and org/images/0031-9155/41/6/004/img7.gif" ALIGN="TOP"/>, respectively. Monte Carlo simulation was used to calculate the absorbed dose to the active volume of the detector per unit air kerma. If the Monte Carlo simulation is accurate, then the absolute detector response, which is defined as the measured detector reading per unit dose absorbed by the active detector volume, and is calculated by Monte Carlo simulation, should be a constant. For the diode, the absolute response is org/images/0031-9155/41/6/004/img8.gif" ALIGN="TOP"/>. For TLDs of size

AphID (Lucid key) http://AphID.AphidNet.org

USDA-ARS?s Scientific Manuscript database

This peer-reviewed web site concentrates on the 66 adult alate and apterous aphids that are the world's most cosmopolitan and polyphagous species. The site includes fact sheets about the various aphids species, a glossary of terms helpful to the student, hundreds of photographs and illustrations, a...

National-Academies.org | Where the Nation Turns for Independent, Expert

Science.gov Websites

Members & Volunteers Presidents' Corner For Sponsors Visiting Our Buildings Working for Us Giving to range of activities where policy meets the life sciences, including the environment, geography : Abortion is safe but barriers reduce quality of care - Associated Press, March 16, 2018 Landmark Report

DiskDetective.org: Finding Homes for Exoplanets Through Citizen Science

NASA Technical Reports Server (NTRS)

Kuchner, Marc J.

2016-01-01

The Disk Detective project is scouring the data archive from the WISE all-sky survey to find new debris disks and protoplanetary disks-the dusty dens where exoplanets form and dwell. Volunteers on this citizen science website have already performed 1.6 million classifications, searching a catalog 8x the size of any published WISE survey. We follow up candidates using ground based telescopes in California, Arizona, Chile, Hawaii, and Argentina. We ultimately expect to increase the pool of known debris disks by approx. 400 and triple the solid angle in clusters of young stars examined with WISE, providing a unique new catalog of isolated disk stars, key planet-search targets, and candidate advanced extraterrestrial civilizations. Come to this talk to hear the news about our latest dusty discoveries and the trials and the ecstasy of launching a new citizen science project. Please bring your laptop or smartphone if you like!

Helioviewer.org: An Open-source Tool for Visualizing Solar Data

NASA Astrophysics Data System (ADS)

Hughitt, V. Keith; Ireland, J.; Schmiedel, P.; Dimitoglou, G.; Mueller, D.; Fleck, B.

2009-05-01

As the amount of solar data available to scientists continues to increase at faster and faster rates, it is important that there exist simple tools for navigating this data quickly with a minimal amount of effort. By combining heterogeneous solar physics datatypes such as full-disk images and coronagraphs, along with feature and event information, Helioviewer offers a simple and intuitive way to browse multiple datasets simultaneously. Images are stored in a repository using the JPEG 2000 format and tiled dynamically upon a client's request. By tiling images and serving only the portions of the image requested, it is possible for the client to work with very large images without having to fetch all of the data at once. Currently, Helioviewer enables users to browse the entire SOHO data archive, updated hourly, as well as data feature/event catalog data from eight different catalogs including active region, flare, coronal mass ejection, type II radio burst data. In addition to a focus on intercommunication with other virtual observatories and browsers (VSO, HEK, etc), Helioviewer will offer a number of externally-available application programming interfaces (APIs) to enable easy third party use, adoption and extension. Future functionality will include: support for additional data-sources including TRACE, SDO and STEREO, dynamic movie generation, a navigable timeline of recorded solar events, social annotation, and basic client-side image processing.

Exploring a Literacy Website that Works: ReadWriteThink.org

ERIC Educational Resources Information Center

Anderson, Rebecca S.; Balajthy, Ernest

2007-01-01

While it is easy to find lesson plans on the Internet, the quality of plans and the formats in which they are written vary considerably, and the process of sifting through the chaff in order to find the wheat can be time-consuming and discouraging. To address these concerns the authors of this Technology in Literacy column introduce…

Vispubdata.org: A Metadata Collection About IEEE Visualization (VIS) Publications.

PubMed

Isenberg, Petra; Heimerl, Florian; Koch, Steffen; Isenberg, Tobias; Xu, Panpan; Stolper, Charles D; Sedlmair, Michael; Chen, Jian; Moller, Torsten; Stasko, John

2017-09-01

We have created and made available to all a dataset with information about every paper that has appeared at the IEEE Visualization (VIS) set of conferences: InfoVis, SciVis, VAST, and Vis. The information about each paper includes its title, abstract, authors, and citations to other papers in the conference series, among many other attributes. This article describes the motivation for creating the dataset, as well as our process of coalescing and cleaning the data, and a set of three visualizations we created to facilitate exploration of the data. This data is meant to be useful to the broad data visualization community to help understand the evolution of the field and as an example document collection for text data visualization research.

Moléculas orgánicas no-rígidas

NASA Astrophysics Data System (ADS)

Senent Díez, M. L.

Se destaca la importancia del estudio espectroscópico ab initio de una serie de moléculas no-rígidas detectadas en el medio interestelar (acetona, dimetil-eter, etanol, metanol, metilamina, ldots), así como los últimos avances del desarrollo de la metodología para el tratamiento teórico de estas especies. Se describe, a modo de ejemplo, el análisis del espectro roto-torsional de la molécula de glicoaldehido que ha sido recientemente detectada en el centro Galáctico Sagitario B2 (N) [1]. Esta especie presenta dos movimientos de gran amplitud que interaccionan, descansan en el Infrarrojo Lejano y le confiere propiedades no-rígidas. La molécula puede existir en posiciones cis y trans y presenta cinco confórmeros estables, tres de simetría Cs (I, II y IV) y un doble mínimo trans de simetría C1 (III) . La conformación favorita, I, presenta simetría Cs y se estabiliza por la formación de un puente de hidrógeno entre los grupos OH y C=O. Los mínimos secundarios II, III, y IV se han determinado a 1278.2 cm-1 (trans, Cs), 1298.8 cm-1 (trans, C1) y 1865.2 cm-1 (cis, Cs) con cálculos MP4/cc-pVQZ que incluyen sustituciones triples. Para determinar que vibraciones interaccionan con las torsiones, se ha realizado un análisis armónico en los mínimos. Las frecuencias fundamentales armónicas correspondientes al mínimo I se han calculado en 213.4 cm-1 (torsión C-C) y 425.7 cm-1 (torsión OH). Es de esperar que tan sólo dos vibraciones, la flexión del grupo C-C-O y el aleteo del hidrógeno del grupo aldehídico puedan desplazar el espectro torsional de la molécula aislada. Para determinar el espectro torsional, se ha determinado la superficie de potencial en dos dimensiones mediante el cálculo ab initio de las geometrías y energías de 74 conformaciones seleccionadas. Estas últimas se han ajustado a un doble serie de Fourier. A partir de la PES y de los parámetros cinéticos del Hamiltoniano vibracional se han obtenido frecuencias e intensidades. Las frecuencias fundamentales se han calculado en 208.0 cm-1 (torsión C-C) y 349.9 cm-1 (torsión OH). Se discute el método de cálculo que se ha empleado para la clasificación de los niveles. Los niveles rotacionales se han determinado empleando el método desarrollado para el estudio del ácido acético [2]. Se emplean la base de funciones rotacionales de [3]. A partir de los niveles se han determinado las constantes rotacionales y las constantes de distorsión centrífuga que se comparan con las experimentales de Herbst et al [3].

[Effects of synthetic neuropeptides in psycho-organic brain syndrome. Results with ACTH4-10 and ACTH4-9-analog (author's transl)].

PubMed

Schneider, E; Jacobi, P; van Riezen, H; Voerman, J W; Fischer, P A

1981-09-01

The effects of ACTH4-10 (Org O163) and of the ACTH4-9 analog (Org 2766) were tested in 20 male patients suffering from a mild to moderate cerebroorganic impairment. Patients were aged between 51-72 years (mean 60.9). Org 2766 was given in dosages of 0.05 mg, 0.5 mg and 5 mg, Org O163 in a dosage of 30 mg. The investigation was based on a randomized incomplete crossover design. By means of psychological tests the effects of the synthetic neuropeptides on memory, state of well-being, attention, vigilance and psychomotor function were investigated. The statistical analysis of the results did not reveal any effects of both substances on the functions tested. These results are in agreement with those of other studies in man using similar methods and acute administration of ACTH4-10 and/or Org 2766. In such studies only effects of reactive inhibition of attention and motivation could be demonstrated consistently.

The Emerging Infrastructure of Autonomous Astronomy

NASA Astrophysics Data System (ADS)

Seaman, R.; Allan, A.; Axelrod, T.; Cook, K.; White, R.; Williams, R.

2007-10-01

Advances in the understanding of cosmic processes demand that sky transient events be confronted with statistical techniques honed on static phenomena. Time domain data sets require vast surveys such as LSST {http://www.lsst.org/lsst_home.shtml} and Pan-STARRS {http://www.pan-starrs.ifa.hawaii.edu}. A new autonomous infrastructure must close the loop from the scheduling of survey observations, through data archiving and pipeline processing, to the publication of transient event alerts and automated follow-up, and to the easy analysis of resulting data. The IVOA VOEvent {http://voevent.org} working group leads efforts to characterize sky transient alerts published through VOEventNet {http://voeventnet.org}. The Heterogeneous Telescope Networks (HTN {http://www.telescope-networks.org}) consortium are observatories and robotic telescope projects seeking interoperability with a long-term goal of creating an e-market for telescope time. Two projects relying on VOEvent and HTN are eSTAR {http://www.estar.org.uk} and the Thinking Telescope {http://www.thinkingtelescopes.lanl.gov} Project.

Reducing an Insurgency’s Foothold: Using Army Sustainability Concepts as a Tool of Security Cooperation for AFRICOM

DTIC Science & Technology

2008-03-04

journal on-line]; available from http://www.cfr.org/publication/ 13255 /; Internet; accessed 5 November 2007. 3 Vince Crawley, USINFO Staff Writer, “U.S...Pentagon’s New Africa Command”, Council on Foreign Relations; 3 May 2007 [journal on-line]; available from http://www.cfr.org/publication/ 13255 ...available from http://www.cfr.org/publication/ 13255 /; Internet; accessed 5 November 2007. Harvey, Francis J. and Schoomaker ,Peter J., General, “2007

When is Information Sufficient for Action Search with Unreliable Yet Informative Intelligence

DTIC Science & Technology

2016-03-30

information: http://pubsonline.informs.org When Is Information Sufficient for Action? Search with Unreliable yet Informative Intelligence Michael Atkinson... Search with Unreliable yet Informative Intelligence. Operations Research Published online in Articles in Advance 30 Mar 2016 . http://dx.doi.org/10.1287...print) � ISSN 1526-5463 (online) http://dx.doi.org/10.1287/opre.2016.1488 © 2016 INFORMS When Is Information Sufficient for Action? Search with

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bartholomew, Mary Jane

To improve the quantitative description of precipitation processes in climate models, the U.S. Department of Energy (DOE)’s Atmospheric Radiation Measurement (ARM) Climate Research Facility deploys several types of rain gauges (MET, RAIN, and optical rain gauge [ORG] datastreams) as well as disdrometers (DISD and VDIS datastreams) at the Southern Great Plains (SGP) Site. This handbook deals specifically with the independent analog ORG (i.e., the ORG datastream).

X-ray spectromicroscopic investigation of natural organochlorine distribution in weathering plant material

NASA Astrophysics Data System (ADS)

Leri, Alessandra C.; Marcus, Matthew A.; Myneni, Satish C. B.

2007-12-01

Natural organochlorine (Cl org) is ubiquitous in soil humus, but the distribution and cycling of different Cl species during the humification of plant material is poorly understood. Our X-ray spectromicroscopic studies indicate that the distributions of Cl org and inorganic Cl -(Cl inorg) in oak leaf material vary dramatically with decay stage, with the most striking changes occurring at the onset of weathering. In healthy or senescent leaves harvested from trees, Cl inorg occurs in sparsely distributed, highly localized "hotspots" associated with trichomes as well as in diffuse concentration throughout the leaf tissue. The Cl inorg associated with trichomes exists either in H-bonded form or in a solid salt matrix, while the Cl inorg in diffuse areas of lower Cl concentration appears exclusively in H-bonded form. Most solid phase Cl inorg leaches from the leaf tissue during early weathering stages, whereas the H-bonded Cl inorg appears to leach away slowly as degradation progresses, persisting through advanced weathering stages. In unweathered leaves, aromatic and aliphatic Cl org were found in rare but concentrated hotspots. In weathered leaves, by contrast, aromatic Cl org hotspots are prevalent, often coinciding with areas of elevated Fe or Mn concentration. Aromatic Cl org is highly soluble in leaves at early weathering stages and insoluble at more advanced stages. These results, combined with optical microscopy, suggest that fungi play a role in the production of aromatic Cl org in weathering leaf material. Aliphatic Cl org occurs in concentrated hotspots in weathered leaves as well as in diffuse areas of low Cl concentration. The distribution and speciation of Cl in weathering oak leaves depicted by this spectromicroscopic study provides new insight into the formation and cycling of Cl org during the decay of natural organic matter.

A multilayered water column in the Ediacaran Yangtze platform? Insights from carbonate and organic matter paired δ13C

NASA Astrophysics Data System (ADS)

Ader, M.; Macouin, M.; Trindade, R. I. F.; Hadrien, M.-H.; Yang, Z.; Sun, Z.; Besse, J.

2009-10-01

Large carbon isotope fluctuations have been systematically reported for Ediacaran carbonate rocks, the meaning of which remains controversial. In order to better understand the mechanisms behind such variations, we present new paired δ13C data on carbonates ( δ13C carb) and their associated organic matter ( δ13C org) from a shelf-margin section (Yangjiaping) of the Doushantuo Formation. In this section, the Doushantuo Formation starts with cap dolostones presenting δ13C carb values around - 5‰ and δ13C org values between - 30.3 and - 27.6‰. Up-section, phased variations in δ13C carb and δ13C org describe positive and negative excursions, while their difference (Δ 13C dol-org = δ13C carb - δ13C org) remains around + 29.2‰. These new data allow the first reconstruction of lateral variations of δ13C carb, δ13C org and Δ 13C carb-org for a shelf-to-basin cross-section of the Yangtze platform (South China) after integration with results reported previously for two other sections. Across the Yangtze platform, the isotope signals reveal strong lateral heterogeneities, with complex variations of δ13C carb and Δ 13C dol-org in the inner-shelf section, phased variations in the shelf-margin section with positive δ13C carb and Δ 13C dol-org close to 29‰, and dominantly negative δ13C carb with δ13C org as low as - 35‰ in the basin. These variations are incompatible with the idea that the δ13C carb can systematically be used as a proxy of ocean surface waters. Assuming that δ13C carb are acquired in bottom waters and/or upper sediments, we show that the heterogeneous δ13C carb and Δ 13C dol-org are compatible with a stratified water column composed of up to three layers: (i) an oxic surface layer, where dissolved inorganic carbon (DIC) is probably in isotope equilibrium with the atmosphere; (ii) an intermediate euxinic layer with a lower δ13C DIC due to organic matter oxidation by ongoing sulphate reduction; (iii) a bottom euxinic layer that

Menu-driven cloud computing and resource sharing for R and Bioconductor

PubMed Central

Bolouri, Hamid; Angerman, Michael

2011-01-01

Summary: We report CRdata.org, a cloud-based, free, open-source web server for running analyses and sharing data and R scripts with others. In addition to using the free, public service, CRdata users can launch their own private Amazon Elastic Computing Cloud (EC2) nodes and store private data and scripts on Amazon's Simple Storage Service (S3) with user-controlled access rights. All CRdata services are provided via point-and-click menus. Availability and Implementation: CRdata is open-source and free under the permissive MIT License (opensource.org/licenses/mit-license.php). The source code is in Ruby (ruby-lang.org/en/) and available at: github.com/seerdata/crdata. Contact: hbolouri@fhcrc.org PMID:21685055

78 FR 74162 - Draft Criminal Justice Offender Tracking System Standard and Companion Documents

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-10

... to the following Web site: https://www.justnet.org/standards/Offender_Tracking_Standards.html . DATES....org/standards/Offender_Tracking_Standards.html . Gregory K. Ridgeway, Acting Director, National...

Metabolomic profiling and sensorial quality of 'Golden Delicious', 'Liberty', 'Santana', and 'Topaz' apples grown using organic and integrated production systems.

PubMed

Vanzo, Andreja; Jenko, Mojca; Vrhovsek, Urska; Stopar, Matej

2013-07-03

Apple quality was investigated in the scab-resistant 'Liberty', 'Santana', and 'Topaz' cultivars and the scab-susceptible 'Golden Delicious' cultivar. Trees subjected to the same crop load were cultivated using either an organic (ORG) or an integrated production (IP) system. Physicochemical properties, phenolic content, and sensorial quality of fruit from both systems were compared. There were no significant differences in fruit mass, starch, and total soluble solid content (the latter was higher in ORG 'Liberty') between ORG and IP fruit, whereas significantly higher flesh firmness was found in ORG fruit (except no difference in 'Golden Delicious'). Significantly higher total phenolic content in ORG fruit was found in 'Golden Delicious', whereas differences in other cultivars were not significant. Targeted metabolomic profiling of multiple classes of phenolics confirmed the impact of the production system on the 'Golden Delicious' phenolic profile as higher levels of 4-hydroxybenzoic acid, neo- and chlorogenic acids, phloridzin, procyanidin B2+B4, -3-O-glucoside and -3-O-galactoside of quercetin, kaempferol-3-O-rutinoside, and rutin being found in ORG fruit. The results obtained suggested that scab resistance influenced the phenolic biosynthesis in relation to the agricultural system. Sensorial evaluation indicated significantly better flavor (except for 'Topaz') and better appearance of IP fruit.

ClimateInterpreter.org: an online sharing platform with best practices and resources on effective climate change communication, climate change exhibits, and sustainability efforts at aquariums, zoos, and science museums

NASA Astrophysics Data System (ADS)

Miller, M. K.; MacKenzie, S.

2011-12-01

Many aquariums, zoos, museums, and other informal science education (ISE) centers across the country want to connect their visitors with the important issue of climate change. Communicating climate change and the science it embodies is no easy task though, and ISE institutions are seeking creative and collaborative ways to best interpret the issue with their audiences. Some of these institutions, particularly aquariums and zoos, have live specimens on exhibit that stand to be severely impacted by climate change. Others see it as an educational and moral imperative to address such an important issue affecting the world today, especially one so close to the core mission of their institution. Regardless, informal science educators have noticed that the public is increasingly coming to them with questions related to climate change, and they want to be able to respond as effectively as they can. The Monterey Bay Aquarium is one partner in a coalition of aquariums, zoos, museums and informal science education institutions that are working together to present climate change to its visitors. These institutions hold enormous public trust as sources of sound scientific information. Whether it is through exhibitions like the Aquarium's Hot Pink Flamingos: Stories of Hope in a Changing Sea, interpretive and communication techniques to navigate challenging climate change discussions, or with sustainability planning and operational greening efforts, there is a concerted movement to improve the capacity of these institutions to respond to the issue. Ultimately, their goal is to inspire visitors in a way that positively impacts the country's discourse surrounding climate change, and helps steer our dialog toward a focus on solutions. In addition to the Hot Pink Flamingos exhibit, the Aquarium is also working with the coalition to build a website, www.climateinterpreter.org, that can serve as an online platform for sharing the experiences of what different partners have learned at

Nitrite Interference with Soluble COD Measurements from Aerobically Treated Wastewater.

PubMed

Ferraz, Fernanda M; Yuan, Qiuyan

2017-06-01

  This study aimed to determine the interference of nitrite (org/1999/xlink" xlink:href="00549-ilm01.gif"/>) with soluble chemical oxygen demand (COD) measurements from the effluent of landfill leachate treated by sequencing batch reactors (SBRs). Synthetic wastewater assimilating young and old landfill leachate was used as influent for SBR1 and SBR2, respectively. A mixture of raw wastewater and landfill leachate was used as influent for SBR3. Due to the high ammonia concentration in the influent, different levels of partial nitrification were observed in all the reactors and org/1999/xlink" xlink:href="00549-ilm12.gif"/> was detected in the effluents. Theoretically, when org/1999/xlink" xlink:href="00549-ilm23.gif"/> is present in the effluent, 1 mg/L of org/1999/xlink" xlink:href="00549-ilm34.gif"/> accounts for 1.1 mg/L of COD (i.e., 1.1 mg COD/mg org/1999/xlink" xlink:href="00549-ilm36.gif"/>) due to the oxidation of org/1999/xlink" xlink:href="00549-ilm37.gif"/> to org/1999/xlink" xlink:href="00549-ilm38.gif"/>. It was found that the value of 1.1 mg COD/mg org/1999/xlink" xlink:href="00549-ilm39.gif"/> was 3 times higher than the values obtained in the experiments with SBR1 and SBR3. In addition, the values obtained in the experiments with SBR2 were much higher than 1.1 mg COD/mg org/1999/xlink" xlink:href="00549-ilm40.gif"/>. These results suggest that the theoretical value of 1.1 mg COD/mg org/1999/xlink" xlink:href="00549-ilm02.gif"/> cannot be applied to predict the COD values caused by nitrite in the tested wastewaters. To obtain

Developmental disorders of the female genital tract

MedlinePlus

... vagina, ovaries, uterus, and cervix; Developmental disorder of female reproductive tract ... CARES Foundation -- www.caresfoundation.org Congenital Adrenal Hyperplasia Education and Support Network -- www.congenitaladrenalhyperplasia.org DES Action ...

Semiconductor Nanowire and Nanoribbon Thermoelectrics: A Comprehensive Computational Study

DTIC Science & Technology

2013-05-01

August 17-20, 2010). Available online through IEEE Xplore . http://dx.doi.org/10.1109/NANO.2010.5698047 4. Z. Aksamija and I. Knezevic...Korea (August 17-20, 2010). Available online through IEEE Xplore . http://dx.doi.org/10.1109/NANO.2010.5697827 5. D. Vasileska, K. Raleva, S. M...IWCE 2010) Available online through IEEE Xplore , http://dx.doi.org/10.1109/IWCE.2010.5677916 6. E. B. Ramayya and I. Knezevic, “Ultrascaled

Migraine - resources

MedlinePlus

Resources - migraine ... The following organizations are good resources for information on migraines : American Migraine Foundation -- americanmigrainefoundation.org National Headache Foundation -- headaches.org National Institute of Neurological Disorders and Stroke -- ...

Blindness - resources

MedlinePlus

Resources - blindness ... The following organizations are good resources for information on blindness : American Foundation for the Blind -- www.afb.org Foundation Fighting Blindness -- www.blindness.org National Eye Institute -- ...

Cancer - resources

MedlinePlus

Resources - cancer ... The following organizations are good resources for information on cancer : American Cancer Society -- www.cancer.org Cancer Care -- www.cancercare.org Cancer.Net -- www.cancer.net/coping- ...

Alcoholism - resources

MedlinePlus

Resources - alcoholism ... The following organizations are good resources for information on alcoholism : Alcoholics Anonymous -- www.aa.org Al-Anon Family Groups www.al-anon.org National Institute on Alcohol ...

Burns - resources

MedlinePlus

Resources - burns ... The following organizations are good resources for information on burns : Burns Recovered -- brsg.org Model Systems Knowledge Translation Center - Burn Model Systems -- www.msktc.org/burn http:// ...

40 CFR Appendix A to Subpart A of... - References

Code of Federal Regulations, 2010 CFR

2010-07-01

...://qualitypress.asq.org). (2) American National Standard Quality Systems for Environmental Data and Technology... P.O. Box 3005, Milwaukee, WI 53202 (http://qualitypress.asq.org). (3) Dimensioning and Tolerancing...

DISTANT EARLY WARNING SYSTEM for Tsunamis - A wide-area and multi-hazard approach

NASA Astrophysics Data System (ADS)

Hammitzsch, Martin; Lendholt, Matthias; Wächter, Joachim

2010-05-01

system and to extend the CCUI with hazard specific functionality. The presentation covers the DEWS project, the system architecture and the CCUI in conjunction with details of information logistics. The DEWS Wide Area Centre connecting national centres to allow the international communication and warning exchange is presented also. REFERENCES: [1] DEWS, www.dews-online.org [2] OGC, www.opengeospatial.org [3] SWE, www.opengeospatial.org/projects/groups/sensorweb [4] Eclipse RCP, www.eclipse.org/home/categories/rcp.php [5] uDig, udig.refractions.net [6] WMS, www.opengeospatial.org/standards/wms [7] WFS, www.opengeospatial.org/standards/wfs [8] WPS, www.opengeospatial.org/standards/wps [9] OASIS, www.oasis-open.org [10] CAP, www.oasis-open.org/specs/#capv1.1 [11] EDXL-DE, www.oasis-open.org/specs/#edxlde-v1.0 [12] SOAP, www.w3.org/TR/soap [13] GITEWS (German Indonesian Tsunami Early Warning System) is a project of the German Federal Government to aid the recon¬struction of the tsunami-prone Indian Ocean region, www.gitews.org [14] The Tsunami Service Bus is the GITEWS sensor system integration platform offering standardised services for the detection and monitoring of tsunamis

Cleft palate - resources

MedlinePlus

Resources - cleft palate ... The following organizations are good resources for information on cleft palate : Cleft Palate Foundation -- www.cleftline.org March of Dimes -- www.marchofdimes.org/complications/cleft-lip-and- ...

Cystic fibrosis - resources

MedlinePlus

Resources - cystic fibrosis ... The following organizations are good resources for information on cystic fibrosis : Cystic Fibrosis Foundation -- www.cff.org March of Dimes -- www.marchofdimes.org/baby/cystic-fibrosis-and- ...

40 CFR Appendix A to Subpart E of... - References

Code of Federal Regulations, 2010 CFR

2010-07-01

..., WI 53202 (http://qualitypress.asq.org). (2) American National Standard Quality Systems for... American Society for Quality, P.O. Box 3005, Milwaukee, WI 53202 (http://qualitypress.asq.org). (3) Quality...

Effect of Mars Atmospheric Loss on Snow Melt Potential in a 3.5 Gyr Mars Climate Evolution Model

NASA Astrophysics Data System (ADS)

Mansfield, Megan; Kite, Edwin S.; Mischna, Michael A.

2018-04-01

Post-Noachian Martian paleochannels indicate the existence of liquid water on the surface of Mars after about 3.5 Gya (Irwin et al., 2015, https://doi.org/10.1016/j.geomorph.2014.10.012; Palucis et al., 2016, https://doi.org/10.1002/2015JE004905). In order to explore the effects of variations in CO2 partial pressure and obliquity on the possibility of surface water, we created a zero-dimensional surface energy balance model. We combine this model with physically consistent orbital histories to track conditions over the last 3.5 Gyr of Martian history. We find that melting is allowed for atmospheric pressures corresponding to exponential loss rates of dP/dt∝t-3.73 or faster, but this rate is within 0.5σ of the rate calculated from initial measurements made by the Mars Atmosphere and Volatile EvolutioN (MAVEN) mission, if we assume all the escaping oxygen measured by MAVEN comes from atmospheric CO2 (Lillis et al., 2017, https://doi.org/10.1002/2016JA023525; Tu et al., 2015, https://doi.org/10.1051/0004-6361/201526146). Melting at this loss rate matches selected key geologic constraints on the formation of Hesperian river networks, assuming optimal melt conditions during the warmest part of each Mars year (Irwin et al., 2015, https://doi.org/10.1016/j.geomorph.2014.10.012; Kite, Gao, et al., 2017, https://doi.org/10.1038/ngeo3033; Kite, Sneed et al., 2017, https://doi.org/10.1002/2017GL072660; Stopar et al., 2006, https://doi.org/10.1016/j.gca.2006.07.039). The atmospheric pressure has a larger effect on the surface energy than changes in Mars's mean obliquity. These results show that initial measurements of atmosphere loss by MAVEN are consistent with atmospheric loss being the dominant process that switched Mars from a melt-permitting to a melt-absent climate (Jakosky et al., 2017, https://doi.org/10.1126/science.aai7721), but non-CO2 warming will be required if <2 Gya paleochannels are confirmed or if most of the escaping oxygen measured by MAVEN comes from H2O.

The Development and Study of Molecular Electronic Switches and their Field-Effect Transistor (FET) Device Properties

DTIC Science & Technology

2015-02-27

Grand Rapids, MI) meetings and conferences. References 1. L.N Lucas, J.J.D. de Jong, J.H. van Esch, R.M. Kellogg , B.L. Berringa. Eur. J. Org...R.M. Kellogg , H.L. Feringa, H.L. Eur. J. Org. Chem., 2003, 155-166. 6. B. Qin, R. Yao, X. Zhao, H. Tian. Org. Biomol. Chem., 1, 2003, 2187-2191...7. L.N. Lucas, J.H. van Euch, R.M. Kellogg , B. Feringa. Chem. Comm., 1998, 2313-2314.

DARPA Ensemble-Based Modeling Large Graphs & Applications to Social Networks

DTIC Science & Technology

2015-07-29

Fortunato, and D. Krioukov. How random are complex networks. Nature Communications , submitted (2015). http://arxiv.org/abs/1505.07503 [p2] I. Miklos...enterprise communication networks, PLOS One, 10(3), e0119446 (2015). http://arxiv.org/abs/1404.3708v3 [p21] A. Nyberg, T. Gross, and K.E. Bassler...using a radiation model based on temporal ranges. Nature Communications , 5, 5347 (2014) | http://arxiv.org/abs/1410.4849 [p28] L.A. Székely, H. Wang

Validating Network Security Policies via Static Analysis of Router ACL Configuration

DTIC Science & Technology

2006-12-01

this research effort. A. SOFTWARE IMPLEMENTATION The system software was created with Java, using NetBeans IDE 5.0 [12]. NetBeans is a free, open...11. P. Gupta, and N. McKeown (2001), Algorithms for Packet Classification, IEEE Network, vol. 15, issue 2, pp. 24-32. 12, NetBeans (2006), Welcome to... NetBeans , http://www.netbeans.org, last accessed on 25 November 2006. 13. IANA.org (2006), Port Numbers, http://www.iana.org/assignments/port

American Academy of Home Care Medicine

MedlinePlus

... Providers) House Call Coding 101 (Coders) Moving to Value and CPC+ Resource Library ... IAHnow.org to contact your senators. Visit IAHnow.org Education AAHCM offers educational resources such as webinars and ...

Delayed puberty in girls

MedlinePlus

... the ovaries A tumor in the pituitary gland Turner syndrome , a genetic disorder ... child's growth: The MAGIC Foundation -- www.magicfoundation.org Turner Syndrome Society of the United States -- www.turnersyndrome.org

78 FR 24290 - Furlough Implementation

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-24

... specific information, please see the FAA Web site at http://www.faa.gov/about/office_org/headquarters...://www.faa.gov/about/office_org/headquarters_offices/avs/operations_sequestration . Issued in Washington...

78 FR 49596 - Order 1050.1F Environmental Impact: Policies and Procedures

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-14

...: Policies and Procedures is available at http://www.faa.gov/about/office_org/headquarters_ offices/apl... categorical exclusion justification package is available at http://www.faa.gov/about/office_org/headquarters...

Pharmaceutical Research and Manufacturers of America

MedlinePlus

... New Medicines Currently in development around the world. Videos No Stone Unturned in Mental Health Research PhRMA.org Watch this Video Together - Alzheimer's Disease PhRMA.org Watch this Video ...

cDNA-AFLP analysis of differential gene expression related to cell chemotactic and encystment of Azospirillum brasilense.

PubMed

Li, Huamin; Cui, Yanhua; Wu, Lixian; Tu, Ran; Chen, Sanfeng

2011-12-20

Our previous study indicated org35 was involved in chemotaxis and interacted with nitrogen fixation transcriptional activator NifA via PAS domain. In order to reveal the role of org35 in nitrogen regulation, the downstream target genes of org35 were identified. We here report differentially expressed genes in org35 mutants comparing with wild type Sp7 by means of cDNA-AFLP. Four up-regulated transcript-derived fragments (TDFs) homologues of chemotaxis transduction proteins were found, including CheW, methyl-accepting chemotaxis protein and response regulator CheY-like receiver. Three distinct TDFs (AB46, AB58 and AB63) were similar to PHB de-polymerase C-terminus, cell shape-determining protein and flagellin domain protein. And 11 TDFs showed similarities with signal transduction proteins, including homologous protein of the nitrogen regulation protein NtrY and nitrate/nitrite response regulator protein NarL. These data suggested that the Azospirillum brasilense org35 was a multi-effecter and involved in chemotaxis, cyst development and regulation of nitrogen fixation. Copyright © 2010 Elsevier GmbH. All rights reserved.

The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice

PubMed Central

Ju, Xiang-Chun; Hou, Qiong-Qiong; Sheng, Ai-Li; Wu, Kong-Yan; Zhou, Yang; Jin, Ying; Wen, Tieqiao; Yang, Zhengang; Wang, Xiaoqun; Luo, Zhen-Ge

2016-01-01

Cortical expansion and folding are often linked to the evolution of higher intelligence, but molecular and cellular mechanisms underlying cortical folding remain poorly understood. The hominoid-specific gene TBC1D3 undergoes segmental duplications during hominoid evolution, but its role in brain development has not been explored. Here, we found that expression of TBC1D3 in ventricular cortical progenitors of mice via in utero electroporation caused delamination of ventricular radial glia cells (vRGs) and promoted generation of self-renewing basal progenitors with typical morphology of outer radial glia (oRG), which are most abundant in primates. Furthermore, down-regulation of TBC1D3 in cultured human brain slices decreased generation of oRGs. Interestingly, localized oRG proliferation resulting from either in utero electroporation or transgenic expression of TBC1D3, was often found to underlie cortical regions exhibiting folding. Thus, we have identified a hominoid gene that is required for oRG generation in regulating the cortical expansion and folding. DOI: http://dx.doi.org/10.7554/eLife.18197.001 PMID:27504805

The spatial data and knowledge gateways at the International Water Management Institute (IWMI)

NASA Astrophysics Data System (ADS)

Thenkabail, P. S.; Biradar, C. M.; Noojipady, P.; Islam, A.; Velpuri, M.; Vithanage, J.; Kulawardhana, W.; Li, Yuan Jie; Dheeravath, V.; Gunasinghe, S.; Alankara, R.

2006-10-01

In this paper we discuss spatial data and knowledge base (SDKB) gateway portals developed by the International Water Management Institute (IWMI). Our vision is to generate and/or facilitate easy and free access to state-of-art SDKB of excellence globally. Our mission is to make SDKB accessible online, globally, for free. The IWMI data storehouse pathway (IWMIDSP; http://www.iwmidsp.org) is a pathfinder global public good (GPG) portal on remote sensing and GIS (RS/GIS) data and products with specific emphasis on river basin data, but also storing valuable data on Nations, Regions, and the World. A number of other specialty GPG portals have also been released. These include Global map of irrigated area (http://www.iwmigiam.org), Drought monitoring system for southwest Asia (http://dms.iwmi.org), Tsunami satellite sensor data catalogue (http://tsdc.iwmi.org), and Knowledge base system (KBS) for Sri Lanka (http://www.iwmikbs.org). The IWMIDSP has been the backbone of several other projects such as global irrigated area mapping, drought monitoring system, wetlands, and knowledge base systems. A discussion on these pathfinder web portals follow.

Celiac disease - resources

MedlinePlus

... Association -- www.csaceliacs.org Gluten Intolerance Group -- www.gluten.org National Institute of Diabetes and Digestive and Kidney Disease -- www.niddk.nih.gov/health-information/digestive-diseases/celiac-disease Beyond Celiac -- www. ...

Transverse Myelitis Association

MedlinePlus

... INSPIRATION What is Anti-Myelin Oligodendrocyte Glycoprotein (MOG)? https://myelitis.org/wp-content/uploads/2015/05/blog_research.jpg 999 1500 The TMA https://myelitis.org/wp-content/uploads/2015/06/TMA- ...

Chronic pain - resources

MedlinePlus

Pain - resources; Resources - chronic pain ... The following organizations are good resources for information on chronic pain: American Chronic Pain Association -- theacpa.org National Fibromyalgia and Chronic Pain Association -- www.fmcpaware.org National ...

75 FR 64752 - Amended Columbia River Basin Fish and Wildlife Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-20

... Council's Web site at http://www.nwcouncil.org/fw/program and then, for the subbasin plan elements and relevant decision documents in particular, at http://www.nwcouncil.org/fw/subbasinplanning/Default.htm...

76 FR 13676 - Amended Columbia River Basin Fish and Wildlife Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-14

... Council's Web site at http://www.nwcouncil.org/fw/program and then, for the subbasin plan elements and relevant decision documents in particular, at http://www.nwcouncil.org/fw/subbasinplanning/Default.htm...

76 FR 11191 - Hazardous Materials: Adoption of ASME Code Section XII and the National Board Inspection Code

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-01

... parts of the National Board Inspection Code at http://www.nationalboard.org . DATES: The comment period... edition of the National Board Inspection Code for public review at www.nationalboard.org . Both documents...

76 FR 13438 - Amended Columbia River Basin Fish and Wildlife Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-11

... Council's Web site at http://www.nwcouncil.org/fw/program and then, for the subbasin plan elements and relevant decision documents in particular, at http://www.nwcouncil.org/fw/subbasinplanning/Default.htm...

Effect of lower and higher alcohol fuel synergies in biofuel blends and exhaust treatment system on emissions from CI engine.

PubMed

Subramanian, Thiyagarajan; Varuvel, Edwin Geo; Martin, Leenus Jesu; Beddhannan, Nagalingam

2017-11-01

The present study deals with performance, emission and combustion studies in a single cylinder CI engine with lower and higher alcohol fuel synergies with biofuel blends and exhaust treatment system. Karanja oil methyl ester (KOME), widely available biofuel in India, and orange oil (ORG), a low carbon biofuel, were taken for this study, and equal volume blend was prepared for testing. Methanol (M) and n-pentanol (P) was taken as lower and higher alcohol and blended 20% by volume with KOME-ORG blend. Activated carbon-based exhaust treatment indigenous system was designed and tested with KOME-ORG + M20 and KOME-ORG + P20 blend. The tests were carried out at various load conditions at a constant speed of 1500 rpm. The study revealed that considering performance, emission and combustion studies, KOME-ORG + M20 + activated carbon are found optimum in reducing NO, smoke and CO 2 emission. Compared to KOME, for KOME-ORG + M20 + activated carbon, NO emission is reduced from 10.25 to 7.85 g/kWh, the smoke emission is reduced from 49.4 to 28.9%, and CO 2 emission is reduced from 1098.84 to 580.68 g/kWh. However, with exhaust treatment system, an increase in HC and CO emissions and reduced thermal efficiency is observed due to backpressure effects.

Feedback | DOE PAGES

Science.gov Websites

Journal Name: Subject: Identifier Numbers: Research Org: Sponsoring Org: Publication Date: to Sort : Relevance (highest to lowest) Publication Date (newest first) Publication Date (oldest first) Most Cited

Diabetes - resources

MedlinePlus

Resources - diabetes ... The following sites provide further information on diabetes: American Diabetes Association -- www.diabetes.org Juvenile Diabetes Research Foundation International -- www.jdrf.org National Center for Chronic Disease Prevention and Health Promotion -- ...

77 FR 19745 - WTO Dispute Settlement Proceeding Regarding United States; Anti-Dumping Measures on Certain...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-02

..., regulations, administrative procedures, practices, and methodologies. That request may be found at www.wto.org... Organization, www.wto.org . Comments open to public inspection may be viewed on the www.regulations.gov Web...

46 CFR 34.01-15 - Incorporation by reference.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., http://www.astm.org. (1) ASTM F 1121-87 (Reapproved 1993), Standard Specification for International...-9101, telephone 800-344-3555, http://www.nfpa.org. (1) NFPA 13-1996, Standard for the Installation of...

Arthritis - resources

MedlinePlus

Resources - arthritis ... The following organizations provide more information on arthritis : American Academy of Orthopaedic Surgeons -- orthoinfo.aaos.org/menus/arthritis.cfm Arthritis Foundation -- www.arthritis.org Centers for Disease Control and Prevention -- www. ...

Mechanism of action of a nanomolar potent, allosteric antagonist of the thyroid-stimulating hormone receptor

PubMed Central

van Koppen, Chris J; de Gooyer, Marcel E; Karstens, Willem-Jan; Plate, Ralf; Conti, Paolo GM; van Achterberg, Tanja AE; van Amstel, Monique GA; Brands, Jolanda HGM; Wat, Jesse; Berg, Rob JW; Lane, J Robert D; Miltenburg, Andre MM; Timmers, C Marco

2012-01-01

BACKGROUND AND PURPOSE Graves' disease (GD) is an autoimmune disease in which the thyroid is overactive, producing excessive amounts of thyroid hormones, caused by thyroid-stimulating hormone (TSH) receptor-stimulating immunoglobulins (TSIs). Many GD patients also suffer from thyroid eye disease (Graves' ophthalmopathy or GO), as TSIs also activate TSH receptors in orbital tissue. We recently developed low molecular weight (LMW) TSH receptor antagonists as a novel therapeutic strategy for the treatment of GD and GO. Here, we determined the molecular pharmacology of a prototypic, nanomolar potent LMW TSH receptor antagonist, Org 274179-0. EXPERIMENTAL APPROACH Using CHO cells heterogeneously expressing human TSH receptors and rat FRTL-5 cells endogenously expressing rat TSH receptors, we determined the potency and efficacy of Org 274179-0 at antagonizing TSH- and TSI-induced TSH receptor signalling and its cross-reactivity at related follicle-stimulating hormone and luteinizing hormone receptors. We analysed the allosteric mode of interaction of Org 274179-0 and determined whether it is an inverse agonist at five naturally occurring, constitutively active TSH receptor mutants. KEY RESULTS Nanomolar concentrations of Org 274179-0 completely inhibited TSH (and TSI)-mediated TSH receptor activation with little effect on the potency of TSH, in accordance with an allosteric mechanism of action. Conversely, increasing levels of TSH receptor stimulation only marginally reduced the antagonist potency of Org 274179-0. Org 274179-0 fully blocked the increased basal activity of all the constitutively active TSH receptor mutants tested with nanomolar potencies. CONCLUSIONS AND IMPLICATIONS Nanomolar potent TSH receptor antagonists like Org 274179-0 have therapeutic potential for the treatment of GD and GO. PMID:22014107

Chloride and organic chlorine in forest soils: storage, residence times, and influence of ecological conditions.

PubMed

Redon, Paul-Olivier; Abdelouas, Abdesselam; Bastviken, David; Cecchini, Sébastien; Nicolas, Manuel; Thiry, Yves

2011-09-01

Recent studies have shown that extensive chlorination of natural organic matter significantly affects chlorine (Cl) residence time in soils. This natural biogeochemical process must be considered when developing the conceptual models used as the basis for safety assessments regarding the potential health impacts of 36-chlorine released from present and planned radioactive waste disposal facilities. In this study, we surveyed 51 French forested areas to determine the variability in chlorine speciation and storage in soils. Concentrations of total chlorine (Cl(tot)) and organic chlorine (Cl(org)) were determined in litterfall, forest floor and mineral soil samples. Cl(org) constituted 11-100% of Cl(tot), with the highest concentrations being found in the humus layer (34-689 mg Cl(org) kg(-1)). In terms of areal storage (53 - 400 kg Cl(org) ha(-1)) the mineral soil dominated due to its greater thickness (40 cm). Cl(org) concentrations and estimated retention of organochlorine in the humus layer were correlated with Cl input, total Cl concentration, organic carbon content, soil pH and the dominant tree species. Cl(org) concentration in mineral soil was not significantly influenced by the studied environmental factors, however increasing Cl:C ratios with depth could indicate selective preservation of chlorinated organic molecules. Litterfall contributions of Cl were significant but generally minor compared to other fluxes and stocks. Assuming steady-state conditions, known annual wet deposition and measured inventories in soil, the theoretical average residence time calculated for total chlorine (inorganic (Cl(in)) and organic) was 5-fold higher than that estimated for Cl(in) alone. Consideration of the Cl(org) pool is therefore clearly important in studies of overall Cl cycling in terrestrial ecosystems.

Cross-Cultural Awareness. Concept

DTIC Science & Technology

2010-11-01

Dirección de Investigación, Doctrina, Orgánica y Materiales ], 18071 Granada, Spain 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING...Organization and Materiel [Dirección de Investigación, Doctrina, Orgánica y Materiales ], Attn: Maj José Fernández-Alfaro, San Idelfonso s/n 18071 Granada...Doctrine, Organization and Materiel [Dirección de Investigación, Doctrina, Orgánica y Materiales ] Attn: Maj José Fernández-Alfaro San Idelfonso

Dietary Regulation of PTEN Signaling and Mammary Tumor Initiating Cells: Implications for Breast Cancer Prevention

DTIC Science & Technology

2011-01-01

All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 1491 at U niversity of A rkansas for M edical S ciences ...U niversity of A rkansas for M edical S ciences Library on A pril 7, 2011 carcin.oxfordjournals.org D ow nloaded from In addition, this dose is...nuclear PTEN–p53 cross talk by GEN 1493 at U niversity of A rkansas for M edical S ciences Library on A pril 7, 2011 carcin.oxfordjournals.org D ow

Avoiding a Pilot Retention Death Spiral: The Pilot Shortage and DOD’s Challenge to Maintain an Effective Fighting Force

DTIC Science & Technology

2018-04-09

pilot retention, they must move beyond solely seeing retention as a money issue and instead address the entire pilot system from production to pay...Shortage is All About the Money ,” ALPA.org, February 27, 2014, http://www.alpa.org/news-and-events/news-room/2014-02-27-Pilot-Shortage-All-About... Money (accessed October 17, 2017). 15 Air Line Pilots Association, “The Landing,” Air Line Pilot Vol. 84, No. 6 (August 2015): 37, http://www3.alpa.org

Strategies used by dairy family farmers in the south of Brazil to comply with organic regulations.

PubMed

Honorato, L A; Machado Filho, L C P; Barbosa Silveira, I D; Hötzel, M J

2014-03-01

The aims of this study were to investigate the environmental, feeding, and health management of organic (ORG) family dairy farms in the south of Brazil in comparison with conventional (CONV) farms, and to assess their degree of compliance with Brazilian organic legislation and the strategies they adopt to accomplish this (n=17 per group). During 2 visits to each farm in March and September, 2010, observations were made on the environment, feed, and health management, followed by bulk milk testing, clinical evaluation, and breed assessment of each individual cow, and an evaluation of diseases and treatments reported within the period. Additional data were collected directly from the farmers through direct interviews. The number of lactating cows was, on average, 11 (range 5 to 19) in the ORG and 16 (range 7 to 42) in the CONV herds. The ORG herds presented a lower percentage of the Holstein breed; whereas CONV herds were predominantly Holstein, in the ORG herds, only 2 herds were 100% Holstein and the remaining herds were crosses of Holstein, Jersey, and Gir (Bos indicus) cattle. Milk production per cow was lower (10.2 vs. 15.1 ± 1.22 L/cow, respectively) in ORG than in the CONV farms. The ORG farms offered less concentrate feed than CONV farms and had better pasture management. Organic farmers reported using phytotherapic and homeopathic products, and pasture management as a strategy to keep infection levels of endo- and ectoparasites low, whereas CONV farmers regularly used anthelmintics and acaricides. Milk production was lower in ORG than in CONV farms, but cow health and condition scores were broadly similar, indicating that the with these strategies ORG farms were able to secure levels of animal welfare comparable with CONV farms while complying with organic regulation, although at the cost of lower cow productivity. Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Online tobacco websites and online communities-who uses them and do users quit smoking? The quit-primo and national dental practice-based research network Hi-Quit studies.

PubMed

Cutrona, Sarah L; Sadasivam, Rajani S; DeLaughter, Kathryn; Kamberi, Ariana; Volkman, Julie E; Cobb, Nathan; Gilbert, Gregg H; Ray, Midge N; Houston, Thomas K

2016-12-01

Online tobacco cessation communities are beneficial but underused. Our study examined whether, among smokers participating in a web-assisted tobacco intervention (Decide2quit.org), specific characteristics were associated with navigating to BecomeAnEx.org, an online cessation community, and with subsequent quit rates. Among smokers (N = 759) registered with Decide2quit.org, we identified visitors to BecomeAnEx.org, examining associations between smoker characteristics and likelihood of visiting. We then tested for associations between visits and 6-month cessation (point prevalence). We also tested for an interaction between use of other online support-seeking (Decide2quit.org tobacco cessation coaches), visiting, and 6-month cessation. One quarter (26.0 %; n = 197) of the smokers visited BecomeAnEx.org; less than one tenth (7.5 %; n = 57) registered to participate in the online forum. Visitors were more likely to be female (73.0 vs. 62.6 % of non-visitors, P < 0.01) to have visited a cessation website before (33.0 vs. 17.4 %, P < 0.01) and to report quit attempts in the previous year (62.0 vs. 53.0 %, P = 0.03). In analyses of all participants, BecomeAnEx.org visiting was not associated with 6-month quit completion. Among participants who communicated with a coach, BecomeAnEx.org visiting also lacked a significant association with 6 month quit completion, although a non-significant trend toward quit completion in visitors was noted (OR 2.21, 95 % CI 0.81-3.1). Online cessation communities attract smokers with previous cessation website experience and recent quit attempts. Community visiting was not associated with quit rates in our study, but low use may have limited our power to detect differences. Further research should explore whether an additive effect can be achieved by offering community visitors support via online coaches.

Appendectomy: Surgical Removal of the Appendix

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78 FR 75559 - Kaukauna Utilities; Notice of Intent To File License Application, Filing of Pre-Application...

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How to Help a Person with a Serious Burn Injury

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Fatty acid profiles, meat quality, and sensory attributes of organic versus conventional dairy beef steers.

PubMed

Bjorklund, E A; Heins, B J; Dicostanzo, A; Chester-Jones, H

2014-03-01

Meat from Holstein and crossbred organic and conventional dairy steers were evaluated and compared for fatty acid profiles, meat quality, sensory attributes, and consumer acceptance. Bull calves (n=49) were randomly assigned to 1 of 3 replicated groups: conventional (CONV), organic (ORG, pasture + concentrate), or grass-fed organic (GRS) and were born at the University of Minnesota West Central Research and Outreach Center (Morris, MN) between March and May 2011. The CONV steers (n=16) were fed a diet that contained 80% concentrate and 20% forage, and ORG steers (n=16) were fed a diet of organic corn, organic corn silage, and organic protein supplement. Furthermore, ORG steers consumed at least 30% of diet dry matter of high-quality organic pasture during the grazing season. The GRS steers (n=17) consumed 100% forage from pasture during the grazing season and high-quality hay or hay silage during the nongrazing season. The ORG steers had fat that was greater in oleic acid (C18:1) than the GRS and CONV steers (47.1, 36.1, and 39.9%, respectively). The GRS steers (21.9%) were lower for monounsaturated fat than the ORG (42.1%) and CONV (40.4%) steers. Furthermore, the GRS steers tended to have greater n-3 fat and had lower n-6 fat than the ORG and CONV steers. Consequently, the GRS (1.4%) steers had a lower n-6-to-n-3 fat ratio than the ORG (12.9%) and CONV (10.0%) steers. The GRS (2.6 kg) steers had steaks that were not different for Warner-Bratzler shear force than ORG (2.3 kg) steaks; however, the GRS steaks tended to have greater shear force than the CONV (2.0 kg) steaks. The 3 steer group had steaks that were not different for color brightness (L*; 0 = black and 100 = white) and yellowness/blueness (b*; positive values = yellow and negative values = blue) values; however, the GRS (10.5) steaks had lower redness/greenness (a*; positive values = red and negative values = green) values than CONV (14.5) steaks. For sensory attributes (0- to 120-point scale), no

Interdisciplinary Collaboration amongst Colleagues and between Initiatives with the Magnetics Information Consortium (MagIC) Database

NASA Astrophysics Data System (ADS)

Minnett, R.; Koppers, A. A. P.; Jarboe, N.; Tauxe, L.; Constable, C.; Jonestrask, L.; Shaar, R.

2014-12-01

Earth science grand challenges often require interdisciplinary and geographically distributed scientific collaboration to make significant progress. However, this organic collaboration between researchers, educators, and students only flourishes with the reduction or elimination of technological barriers. The Magnetics Information Consortium (http://earthref.org/MagIC/) is a grass-roots cyberinfrastructure effort envisioned by the geo-, paleo-, and rock magnetic scientific community to archive their wealth of peer-reviewed raw data and interpretations from studies on natural and synthetic samples. MagIC is dedicated to facilitating scientific progress towards several highly multidisciplinary grand challenges and the MagIC Database team is currently beta testing a new MagIC Search Interface and API designed to be flexible enough for the incorporation of large heterogeneous datasets and for horizontal scalability to tens of millions of records and hundreds of requests per second. In an effort to reduce the barriers to effective collaboration, the search interface includes a simplified data model and upload procedure, support for online editing of datasets amongst team members, commenting by reviewers and colleagues, and automated contribution workflows and data retrieval through the API. This web application has been designed to generalize to other databases in MagIC's umbrella website (EarthRef.org) so the Geochemical Earth Reference Model (http://earthref.org/GERM/) portal, Seamount Biogeosciences Network (http://earthref.org/SBN/), EarthRef Digital Archive (http://earthref.org/ERDA/) and EarthRef Reference Database (http://earthref.org/ERR/) will benefit from its development.

Getting Help

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Mammography

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77 FR 37730 - WTO Dispute Settlement Proceeding Regarding United States-Countervailing Duty Measures on Certain...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-22

... for consultations may be found at www.wto.org contained in a document designated as WT/DS437/1. USTR..., will be available on the Web site of the World Trade Organization, www.wto.org . Comments open to...

77 FR 53959 - WTO Dispute Settlement Proceeding Regarding Argentina-Measures Affecting the Importation of Goods

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-04

... by Argentina on the importation of goods. That request may be found at www.wto.org , contained in a... Appellate Body, will also be available on the Web site of the World Trade Organization at www.wto.org...

75 FR 504 - In the Matter of the Review of the Designation of Kahane Chai (aka American Friends of the United...

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2010-01-05

... Lives aka Kahane Tzadak aka Kahane.org aka Kahanetzadak.com aka Kfar Tapuah Fund aka KOACH aka Meir's Youth aka New Kach Movement aka newkach.org aka No'ar Meir aka Repression of Traitors aka State of Judea...

[Transformation Regularity of Nitrogen in Aqueous Product Derived from Hydrothermal Liquefaction of Sewage Sludge in Subcritical Water].

PubMed

Sun, Yan-qing; Sun, Zhen; Zhang, Jing-lai

2015-06-01

Hydrothermal liquefaction in subcritical water is a potential way to treat sewage sludge as a resource rather than a waste. This study focused on the transformation regularity of nitrogen in aqueous product which was derived from hydrothermal liquefaction of sewage sludge under different operating conditions. Results showed, within the studied temperature scope and time span, the concentration of total nitrogen (TN) fluctuated in the range of 2867.62 mg x L(-1) to 4171.30 mg x L(-1). The two major exiting formation of nitrogen in aqueous product was ammonia nitrogen (NH4+ -N) and organic nitrogen (Org-N). NH4+ -N possessed 54.6%-90.7% of TN, while Org-N possessed 7.4%-44.5%. The concentration of nitrate nitrogen (NO- -N) was far more less than NH4+ -N and Org-N. Temperature had a great influence on the transformation regularity of nitrogen. Both the concentration of TN and Org-N increased accordingly to the increase of reaction temperature. With the reaction time prolonging, the concentration of TN and Org-N increased, while the concentration of NH4+ -N increased first, then became stationary, and then decreased slightly.

New species of Mesozoic benthic foraminifera from the former British Petroleum micropalaeontology collection

NASA Astrophysics Data System (ADS)

Fox, Lyndsey R.; Stukins, Stephen; Hill, Tom; Bailey, Haydon W.

2018-05-01

This paper describes five new Mesozoic, deep-water benthic foraminifera from the former British Petroleum microfossil reference collections at the Natural History Museum, London. The focus is on selected calcareous and agglutinating taxa that are of stratigraphical and/or palaeoecological significance for academic and industrial related activities. Ophthalmidium dracomaris (urn:lsid:zoobank.org:act:CCE951DF-0446-416B-AC2D-C5322CD335D2), Trochammina fordonensis (urn:lsid:zoobank.org:act:4F00A270-F9B2-46D4-8587-C7ADCC191D13), Eobigenerina calloviensis (urn:lsid:zoobank.org:act:B8443AA5-CFE4-44C0-A5A2-65EA97BF7EFA), Arenoturrispirillina swiecickii (urn:lsid:zoobank.org:act:06A35E03-5AA4-4363-B471-4E1A0091F62E) and Ataxophragmium mariae (urn:lsid:zoobank.org:act:B8443AA5-CFE4-44C0-A5A2-65EA97BF7EFA) are described with new illustrations. Their biostratigraphic and palaeoecological significance are briefly discussed.

Advisory Committee on Immunization Practices Recommended Immunization Schedule for Adults Aged 19 Years or Older - United States, 2017.

PubMed

Kim, David K; Riley, Laura E; Harriman, Kathleen H; Hunter, Paul; Bridges, Carolyn B

2017-02-10

In October 2016, the Advisory Committee on Immunization Practices (ACIP) voted to approve the Recommended Adult Immunization Schedule for Adults Aged 19 Years or Older-United States, 2017. The 2017 adult immunization schedule summarizes ACIP recommendations in two figures, footnotes for the figures, and a table of contraindications and precautions for vaccines recommended for adults. These documents are available at https://www.cdc.gov/vaccines/schedules. The full ACIP recommendations for each vaccine can be found at https://www.cdc.gov/vaccines/hcp/acip-recs/index.html. The 2017 adult immunization schedule was also reviewed and approved by the American College of Physicians (https://www.acponline.org), the American Academy of Family Physicians (https://www.aafp.org), the American College of Obstetricians and Gynecologists (http://www.acog.org), and the American College of Nurse-Midwives (http://www.midwife.org).

Link-Prediction Enhanced Consensus Clustering for Complex Networks (Open Access)

DTIC Science & Technology

2016-05-20

92:022816. Available from: http://link.aps.org/doi/10.1103/PhysRevE.92.022816. doi: 10. 1103 /PhysRevE.92.022816 16. Aldecoa R, Marín I. Exploring the...from: http://link.aps.org/doi/10.1103/PhysRevE.80.056117. doi: 10. 1103 /PhysRevE.80.056117 18. Dahlin J, Svenson P. Ensemble approaches for improving...046110. Available from: http://link.aps.org/doi/10.1103/PhysRevE.81.046110. doi: 10. 1103 /PhysRevE.81.046110 28. Gfeller D, Chappelier JC, De Los Rios P

Weight-loss surgery - after - what to ask your doctor

MedlinePlus

... your doctor; What to ask your doctor after weight-loss surgery ... American Society for Metabolic and Bariatric Surgery. Life after bariatric surgery. ASMBS.org web site. asmbs.org/patients/life-after-bariatric-surgery . Accessed February 2, 2017. Mechanick JI, ...

77 FR 46788 - WTO Dispute Settlement Proceeding Regarding China-Anti-Dumping and Countervailing Duties on...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-06

... request may be found at www.wto.org , contained in a document designated as WT/DS440/1. USTR invites... Appellate Body, will also be available on the Web site of the World Trade Organization at www.wto.org...

78 FR 58378 - WTO Dispute Settlement Proceeding Regarding Anti-Dumping and Countervailing Measures on Large...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-23

... request may be found at www.wto.org in a document designated as WT/DS464/1. USTR invites written comments... available on the Web site of the World Trade Organization, at www.wto.org . Comments open to public...

77 FR 73732 - WTO Dispute Settlement Proceeding Regarding United States ; Countervailing and Anti-Dumping...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-11

... below. The panel request may be found at www.wto.org contained in a document designated as WT/DS449/2... Organization, www.wto.org . Comments open to public inspection may be viewed on the www.regulations.gov Web...

75 FR 20670 - WTO Dispute Settlement Proceeding Regarding United States-Use of Zeroing in Anti-Dumping Measures...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-20

.... That request may be found at http://www.wto.org in a document designated as WT/DS402/3. USTR invites... of the World Trade Organization, http://www.wto.org . Comments will be placed in the docket and open...

Publications - DDS 9 | Alaska Division of Geological & Geophysical Surveys

Science.gov Websites

Surveys Digital Data Series 9, http://doi.org/10.14509/shoreline. http://doi.org/10.14509/29504 positions in the Alaska shoreline change tool, 11 p. Digital Geospatial Data Digital Geospatial Data Emmonak

Hepatitis B Shots Are Recommended for All New Babies

MedlinePlus

... Centers for Disease Control and Prevention Saint Paul, Minnesota • 651-647-9009 • www. immunize. org • www. vaccineinformation. ... Centers for Disease Control and Prevention Saint Paul, Minnesota • 651-647-9009 • www.immunize.org • www.vaccineinformation. ...

Proven Weight Loss Methods

MedlinePlus

Fact Sheet Proven Weight Loss Methods What can weight loss do for you? Losing weight can improve your health in a number of ways. It can lower ... at www.hormone.org/Spanish . Proven Weight Loss Methods Fact Sheet www.hormone.org

Open chemistry registry and mapping platform based on open source cheminformatics toolkits (ACS Fall meeting)

EPA Science Inventory

TheOpen PHACTS project (openphacts.org) is a European initiative, constituting a public–private partnership to enable easier, cheaper and faster drug discovery [1]. The project is supported by the Open PHACTS Foundation (www.openphactsfoundation.org) and funded by contributions f...

Spina Bifida Clinic Directory

MedlinePlus

... 7th Avenue S. Birmingham, AL 35233 (205) 939-5281 https://www.childrensal.org/SpinaBifidaProgram UAB Spain Rehab Adult ... Ave S Birmingham, AL 35249 Phone: (205) 934-4131 http://www.uabmedicine.org/locations/spain-rehabilitation-center Children’s ...

The Case for Spacecrime: The Rise of Crime and Piracy in the Space Domain

DTIC Science & Technology

2013-06-01

resulted in generally outdated hardware with limited capabilities.21 More recent hardware platforms such as Arduino, BeagleBone, Raspberry Pi and others...www.citizensinspace.org; Arduino platform, http://www.arduino.cc; Beaglebone platform, http://www.beagleboard.org; Raspberry Pi platform, http

40 CFR 1048.810 - What materials does this part reference?

Code of Federal Regulations, 2010 CFR

2010-07-01

....org. Table 1 follows: Table 1 of § 1048.810—SAE Materials Document number and name Part 1048reference..., Switzerland or http://www.iso.org. Table 2 follows: Table 2 of § 1048.810—ISO Materials Document number and...

75 FR 50033 - WTO Dispute Settlement Proceeding Regarding United States-Measures Affecting the Production and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-16

... (Pub. L. 111-31). That request may be found at http://www.wto.org in a document designated as WT/DS406... Organization, http://www.wto.org . Comments will be placed in the docket and open to public inspection pursuant...

33 CFR Appendix to Subpart D of... - Ballast Water Reporting Form and Instructions for Ballast Water Reporting Form

Code of Federal Regulations, 2010 CFR

2010-07-01

... Internet at http://invasions.si.edu/NBIC/bwform.html; E-mail to [email protected]ORG; Fax to 301-261-4319...:Via the Internet at http://invasions.si.edu/NBIC/bwform.html; E-mail to [email protected]ORG; Fax to...

United States Army Counter Partisan Operations in Northern Virginia During the American Civil War

DTIC Science & Technology

2016-06-10

War Centennial Commission, accessed January 10, 2016, http://www.loudounhistory.org/history/ loudoun-cw-mosby-burning-raid.htm. This article...Mosby’s Raids. Edited by Fitzhugh Turner. Virginia Civil War Centennial Commission. Accessed January 10, 2016. http://www.loudounhistory.org/history

Analysis of the Effects of Phase Noise and Frequency Offset in Orthogonal Frequency Division Multiplexing (OFDM) Systems

DTIC Science & Technology

2004-03-01

Data Communication , http://www.iec.org/, last accessed December 2003. 13. Klaus Witrisal, “Orthogonal Frequency Division Multiplexing (OFDM) for...http://ieeexplore.ieee.org, last accessed 26 February 2003. 12. The International Engineering Consortium, Web Forum Tutorials, OFDM for Mobile

Cloud property datasets retrieved from AVHRR, MODIS, AATSR and MERIS in the framework of the Cloud_cci project

NASA Astrophysics Data System (ADS)

Stengel, Martin; Stapelberg, Stefan; Sus, Oliver; Schlundt, Cornelia; Poulsen, Caroline; Thomas, Gareth; Christensen, Matthew; Carbajal Henken, Cintia; Preusker, Rene; Fischer, Jürgen; Devasthale, Abhay; Willén, Ulrika; Karlsson, Karl-Göran; McGarragh, Gregory R.; Proud, Simon; Povey, Adam C.; Grainger, Roy G.; Fokke Meirink, Jan; Feofilov, Artem; Bennartz, Ralf; Bojanowski, Jedrzej S.; Hollmann, Rainer

2017-11-01

impact of temporal sampling and spatial resolution on cloud climatologies.

For each dataset a digital object identifier has been issued:

Cloud_cci AVHRR-AM: org/10.5676/DWD/ESA_Cloud_cci/AVHRR-AM/V002" target="_blank">https://doi.org/10.5676/DWD/ESA_Cloud_cci/AVHRR-AM/V002

Cloud_cci AVHRR-PM: org/10.5676/DWD/ESA_Cloud_cci/AVHRR-PM/V002" target="_blank">https://doi.org/10.5676/DWD/ESA_Cloud_cci/AVHRR-PM/V002

Cloud_cci MODIS-Terra: org/10.5676/DWD/ESA_Cloud_cci/MODIS-Terra/V002" target="_blank">https://doi.org/10.5676/DWD/ESA_Cloud_cci/MODIS-Terra/V002

Cloud_cci MODIS-Aqua: org/10.5676/DWD/ESA_Cloud_cci/MODIS-Aqua/V002" target="_blank">https://doi.org/10.5676/DWD/ESA_Cloud_cci/MODIS-Aqua/V002

Cloud_cci ATSR2-AATSR: org/10.5676/DWD/ESA_Cloud_cci/ATSR2-AATSR/V002" target="_blank">https://doi.org/10.5676/DWD/ESA_Cloud_cci/ATSR2-AATSR/V002

Cloud_cci MERIS+AATSR: org/10.5676/DWD/ESA_Cloud_cci/MERIS+AATSR/V002" target="_blank">https://doi.org/10.5676/DWD/ESA_Cloud_cci/MERIS+AATSR/V002

winderosionnetwork.org – Portal to the National Wind Erosion Research Network

USDA-ARS?s Scientific Manuscript database

The National Wind Erosion Research Network was established in 2014 as a collaborative effort led by the USDA Agricultural Research Service and Natural Resources Conservation Service, and USDI Bureau of Land Management, to address the need for standardized measurements of wind erosion and its control...

Associations among Measures of Engagement with KP.Org and Clinical Outcomes

ERIC Educational Resources Information Center

Sobko, Heather J.

2011-01-01

Introduction. The purpose of this retrospective cohort study was to examine patterns of use of an electronic personal health record among adults diagnosed with diabetes, hypertension or hyperlipidemia. Intermediate behavioral measures (medication possession ratios) and physiological measures of metabolic control for diabetes (hemoglobinA1c),…

Long-lasting ovulation inhibition with a new injectable progestagen ORG-2154.

PubMed

Coutinho, E M; De Souza, J C; Barbosa, I C; Dourado Silva, V

1982-06-01

A new long-acting injectable progestagen was tested in 15 women who volunteered for the study. The occurrence of ovulation was assumed by the elevation of progesterone levels above 2ng/ml following a pre-ovulatory estradiol peak. Following a 200mg injection, ovulation was inhibited in all 15 women for five to ten months. In four subjects the interval between the injection and the first progesterone peak was five months. For eight, the interval was six to eight months. In the other three women, ovulation occurred more than eight months following injection. Bleeding episodes, similar to menstruation, occurred in most patients. Bleeding intervals lasting longer than 45 days occurred in nine subjects but more prolonged amenorrhea lasting longer than 60 days was reported by only five subjects. Blood chemistry which included blood cell counts, cholesterol, glucose, alkaline phosphatase, transaminases, urea nitrogen and creatinine remained within normal limits throughout the treatment.

bold: The Barcode of Life Data System (http://www.barcodinglife.org)

PubMed Central

RATNASINGHAM, SUJEEVAN; HEBERT, PAUL D N

2007-01-01

The Barcode of Life Data System (bold) is an informatics workbench aiding the acquisition, storage, analysis and publication of DNA barcode records. By assembling molecular, morphological and distributional data, it bridges a traditional bioinformatics chasm. bold is freely available to any researcher with interests in DNA barcoding. By providing specialized services, it aids the assembly of records that meet the standards needed to gain BARCODE designation in the global sequence databases. Because of its web-based delivery and flexible data security model, it is also well positioned to support projects that involve broad research alliances. This paper provides a brief introduction to the key elements of bold, discusses their functional capabilities, and concludes by examining computational resources and future prospects. PMID:18784790

Helioviewer.org: Browsing Very Large Image Archives Online Using JPEG 2000

NASA Astrophysics Data System (ADS)

Hughitt, V. K.; Ireland, J.; Mueller, D.; Dimitoglou, G.; Garcia Ortiz, J.; Schmidt, L.; Wamsler, B.; Beck, J.; Alexanderian, A.; Fleck, B.

2009-12-01

As the amount of solar data available to scientists continues to increase at faster and faster rates, it is important that there exist simple tools for navigating this data quickly with a minimal amount of effort. By combining heterogeneous solar physics datatypes such as full-disk images and coronagraphs, along with feature and event information, Helioviewer offers a simple and intuitive way to browse multiple datasets simultaneously. Images are stored in a repository using the JPEG 2000 format and tiled dynamically upon a client's request. By tiling images and serving only the portions of the image requested, it is possible for the client to work with very large images without having to fetch all of the data at once. In addition to a focus on intercommunication with other virtual observatories and browsers (VSO, HEK, etc), Helioviewer will offer a number of externally-available application programming interfaces (APIs) to enable easy third party use, adoption and extension. Recent efforts have resulted in increased performance, dynamic movie generation, and improved support for mobile web browsers. Future functionality will include: support for additional data-sources including RHESSI, SDO, STEREO, and TRACE, a navigable timeline of recorded solar events, social annotation, and basic client-side image processing.

Stroke subtyping for genetic association studies? A comparison of the CCS and TOAST classifications.

PubMed

Lanfranconi, Silvia; Markus, Hugh S

2013-12-01

A reliable and reproducible classification system of stroke subtype is essential for epidemiological and genetic studies. The Causative Classification of Stroke system is an evidence-based computerized algorithm with excellent inter-rater reliability. It has been suggested that, compared to the Trial of ORG 10172 in Acute Stroke Treatment classification, it increases the proportion of cases with defined subtype that may increase power in genetic association studies. We compared Trial of ORG 10172 in Acute Stroke Treatment and Causative Classification of Stroke system classifications in a large cohort of well-phenotyped stroke patients. Six hundred ninety consecutively recruited patients with first-ever ischemic stroke were classified, using review of clinical data and original imaging, according to the Trial of ORG 10172 in Acute Stroke Treatment and Causative Classification of Stroke system classifications. There was excellent agreement subtype assigned by between Trial of ORG 10172 in Acute Stroke Treatment and Causative Classification of Stroke system (kappa = 0·85). The agreement was excellent for the major individual subtypes: large artery atherosclerosis kappa = 0·888, small-artery occlusion kappa = 0·869, cardiac embolism kappa = 0·89, and undetermined category kappa = 0·884. There was only moderate agreement (kappa = 0·41) for the subjects with at least two competing underlying mechanism. Thirty-five (5·8%) patients classified as undetermined by Trial of ORG 10172 in Acute Stroke Treatment were assigned to a definite subtype by Causative Classification of Stroke system. Thirty-two subjects assigned to a definite subtype by Trial of ORG 10172 in Acute Stroke Treatment were classified as undetermined by Causative Classification of Stroke system. There is excellent agreement between classification using Trial of ORG 10172 in Acute Stroke Treatment and Causative Classification of Stroke systems but no evidence that Causative

Soil organic matter as an important contributor to Late Quaternary sediments of the tropical West African continental margin

NASA Astrophysics Data System (ADS)

Holtvoeth, Jens; Kolonic, Sadat; Wagner, Thomas

2005-04-01

The contribution of soil organic matter (SOM) to continental margins is largely ignored in studies on the carbon budget of marine sediments. Detailed geochemical investigations of late Quaternary sediments (245-0 ka) from the Niger and Congo deep-sea fans, however, reveal that C org/N tot ratios and isotopic signatures of bulk organic matter (δ 13C org) in both fans are essentially determined by the supply of various types of SOM from the river catchments thus providing a fundamentally different interpretation of established proxies in marine sciences. On the Niger fan, increased C org/N tot and δ 13C org (up to -17‰) were driven by generally nitrogen-poor but 13C-enriched terrigenous plant debris and SOM from C 4/C 3 vegetation/Entisol domains (grass- and tree-savannah on young, sandy soils) supplied during arid climate conditions. Opposite, humid climates supported drainage of C 3/C 4 vegetation/Alfisol/Ultisol domains (forest and tree-savannah on older/developed, clay-bearing soils) that resulted in lower C org/N tot and δ 13C org (< -20‰) in the Niger fan record. Sediments from the Congo fan contain a thermally stable organic fraction that is absent on the Niger fan. This distinct organic fraction relates to strongly degraded SOM of old and highly developed, kaolinite-rich ferallitic soils (Oxisols) that cover large areas of the Congo River basin. Reduced supply of this nitrogen-rich and 12C-depleted SOM during arid climates is compensated by an elevated input of marine OM from the high-productive Congo up-welling area. This climate-driven interplay of marine productivity and fluvial SOM supply explains the significantly smaller variability and generally lower values of C org/N tot and δ 13C org for the Congo fan records. This study emphasizes that ignoring the presence of SOM results in a severe underestimation of the terrigenous organic fraction leading to erroneous paleoenvironmental interpretations at least for continental margin records

Agricultural management legacy affects microbial energetics, resource utilization and active bacterial community membership during 13C-glucose consumption

NASA Astrophysics Data System (ADS)

Helgason, B. L.; Levy-Booth, D.; Arcand, M. M.

2017-12-01

Over the long-term, differences in soil management can result in fundamental changes in biogeochemical cycling. The Alternative Cropping Systems (ACS) Study at Scott, SK, Canada (est. 1994) compares organic (ORG) vs. conventionally (CON) managed crop rotations in a loamy Typic Borall. Nitrogen (N) and phosphorus (P) deficiency in the ORG systems have limited crop growth and thus plant carbon (C) inputs for over two decades, ultimately resulting in a C deficiency which has further altered biogeochemical cycling. We conducted a short-term microcosm experiment using 13C-glucose stable isotope probing (SIP) of DNA to test whether ORG soils have greater microbial C use efficiency due to long term resource limitation. Glucose-utilizing populations were dominated by Proteobacteria and Actinobacteria, with differing species-level identities and physiological capacities between CON and ORG systems. Of the 13C-utilizing taxa, relative abundance of Proteobacteria was greater in CON while Actinobacteria (and notably Firmicutes) were more dominant in ORG soils. Using isothermal calorimetry, we measured a thermodynamic efficiency (ηeff) of 0.68, which was not significantly different between soils indicating that the metabolic cost of glucose utilization was similar in CON and ORG soils. In spite of this, differential abundance analysis of 13C-labelled OTUs revealed that ORG soils had distinct active bacterial populations that were positively correlated with ηeff, ηsoil (glucose energy retained in soil) and primed soil organic matter (pSOM). In contrast, differentially abundant OTUs in the CON soils were negatively correlated with measures of thermodynamic efficiency but positively correlated with glucose-derived heat and CO2 production as well as NO3- and PO4- availability. ORG bacterial communities may co-metabolize other resources (N and P) from SOM to meet their metabolic requirements during glucose utilization, while the active bacteria in the CON soils could access these

Resubmission of Gap Analysis Workshop for Training for Reintegration of Surgical Skills

DTIC Science & Technology

2011-10-01

the ABS, many other organizations do not have current reentry requirements but work with physicians on a case-by-case basis. Global competency...facs.org/education/ • Animal Labs • American Urological Association (AUA) Core Curriculum - http://www.auanet.org/eforms/ elearning /core

"Life after Last Orders": Microbiology as a Career

ERIC Educational Resources Information Center

Verran, Joanna

2004-01-01

The 2003 conference of the International Biodegradation and Biodeterioration Society (www.biodeterioration. org) and the International Biodegradation Research Group (www.ibrg.org), was held last September at the Manchester Metropolitan University. The conference, "Management and Control of Undesirable Microorganisms", followed the usual…

Osler-Weber-Rendu syndrome

MedlinePlus

... your provider what other precautions you should take. Support Groups These resources can provide more information on HHT: Centers for Disease Control and Prevention -- www.cdc.gov/ncbddd/hht Cure HHT -- curehht.org National Organization for Rare Disorders -- rarediseases.org/rare-diseases/hereditary- ...

Ensembl genomes 2016: more genomes, more complexity

USDA-ARS?s Scientific Manuscript database

Ensembl Genomes (http://www.ensemblgenomes.org) is an integrating resource for genome-scale data from non-vertebrate species, complementing the resources for vertebrate genomics developed in the context of the Ensembl project (http://www.ensembl.org). Together, the two resources provide a consistent...

What do dendrites and their synapses tell the neuron?

PubMed

Segev, Idan

2006-03-01

This essay looks at the historical significance of four APS classic papers that are freely available online: Rall W. Distinguishing theoretical synaptic potentials computed for different soma-dendritic distributions of synaptic input. J Neurophysiol 30: 1138-1168, 1967 (http://jn.physiology.org/cgi/reprint/30/5/1138). Rall W, Burke RE, Smith TG, Nelson PG, and Frank K. Dendritic location of synapses and possible mechanisms for the monosynaptic EPSP in motoneurons. J Neurophysiol 30: 1169-1193, 1967 (http://jn.physiology.org/cgi/reprint/30/5/1169). Rall W and Shepherd GM. Theoretical reconstruction of field potentials and dendrodendritic synaptic interactions in olfactory bulb. J Neurophysiol 31: 884-915, 1968 (http://jn.physiology.org/cgi/reprint/31/6/884). Segev I and Rall W. Computational study of an excitable dendritic spine. J Neurophysiol 60: 499-523, 1988 (http://jn.physiology.org/cgi/reprint/60/2/499).

Open Source: Potential in Latin America for Radiological Weapons

DTIC Science & Technology

2010-03-01

Limos Project,” The NEFA Foundation, http://www.nefafoundation.org/miscellaneous/Barot/GasLimos.pdf (accessed 18 March 2010), 31. 44 Dhiren, “Rough...March 2010). Barot, Dhiren. "Rough Presentation for Gas Limos Project." The NEFA Foundation. http://www.nefafoundation.org/miscellaneous/Barot

Family Caregivers for Veterans with Spinal Cord Injury: Exploring the Stresses and Benefits

DTIC Science & Technology

2013-10-01

jcoker@craighospital.org; Susie @craighospital.org 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING...availability of family caregiving is crucial to most veterans with SCI, but there is little research addressing the topic, and no appropriate and

Family Caregivers for Veterans with Spinal Cord Injury: Exploring the Stresses and Benefits

DTIC Science & Technology

2014-10-01

jcoker@craighospital.org; Susie @craighospital.org 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING...availability of family caregiving is crucial to most veterans with SCI, but there is little research addressing the topic, and no appropriate and

The Economics of Counterinsurgency in the Philippines

DTIC Science & Technology

2016-09-30

www.nber.org/papers/w21849 Berman, Eli , Joseph Felter, Ethan Kapstein, and Erin Troland, "Predation, Taxation , Investment, and Violence: Evidence...Erin Troland, "Predation, Taxation , Investment and Violence: Evidence from the Philippines," NBER Working Paper No. 19266, 2013. http://www.nber.org

Koinonia: The Requirements and Vision for an Unclassified Information-Sharing System

DTIC Science & Technology

2013-06-01

of an effort to share information with multinational partners in Multinational Planning Augmentation Team (MPAT) ( Tempest Express Fact Sheet 2011... Tempest fact sheet. Global Security.org. May 7, 2011. Accessed May 3, 2013. http://www.globalsecurity.org/military/ops/ tempest -express.htm U.S

Porphyria Cutanea Tarda (PCT)

MedlinePlus

... the UROD enzyme in red blood cells (erythrocytes). Molecular genetic testing is available for familial PCT if the ... org.uk Website: http://www.porphyria.org.uk Genetic and Rare ... porphyrias. In: The Metabolic and Molecular Basis of Inherited Disease, 8th ed. Scriver CR, ...

Phytoplankton species diversity indices in Anjanapura reservoir, Western Ghat region, India.

PubMed

Basavaraja, D; Narayana, J; Puttaiah, E T; Prakash, K

2013-07-01

A qualitative study on species composition and diversity of phytoplankton flora was carried out in the Anjanapura reservoir. Water samples were collected monthly at four sites from November 2005 to October 2007 for plankton analysis. A total of 152 phytoplankton species belonging to 59 genera were recorded. The species belonging to genera Crucigenia, Pediastrum, Scenedesmus, Tetraedron, Cyclotella, Gyrosigma, Melosira, Navicula, Fragillaria, pinnularia, Synedra, Closterium, Cosmarium, Euastrum, Staurastrum, Gleocapsa, Merismopedia, Microcystis, Oscillatoria, Euglena and Phacus were found dominant. Phytoplankton density was recorded in the range of 222-1467 Org l(-1) for chlorococcales, 267-1467 Org I (-1) for diatoms, 44-889 Org l(-1) for desmids, 44-889 Org l(-1) for blue-greens and 22-1667 Org l(-1) for euglenoids. Seasonal density Shannon-Weiner diversity index (1.60-1.88) indicate that reservoir exhibited rich phytoplankton and Nygaard tropic status indices for myxophycean (1.0-1.50), chlorophycean (1.62-2.16), diatoms (0.10-0.14), euglenophycean (0.18-0.19) and compound quotient(3.25-4.66) showed that reservoir was moderately polluted. From the observed data, it could be concluded that the presence of more diverse group of phytoplankton indicate the productivity of the reservoir.

40 CFR Appendix A to Subpart E of... - References

Code of Federal Regulations, 2012 CFR

2012-07-01

..., WI 53202 (http://qualitypress.asq.org). (2) American National Standard Quality Systems for... American Society for Quality, P.O. Box 3005, Milwaukee, WI 53202 (http://qualitypress.asq.org). (3) Quality... 1998 or later edition. Currently available at http://www.epa.gov/ttn/amtic/pmqainf.html. (4) Military...

CatReg Software for Categorical Regression Analysis (Jul 2012)

EPA Science Inventory

CatReg is a computer program, written in the R (org">http://cran.r-project.org) programming language, to support the conduct of exposure-response analyses by toxicologists and health scientists. CatReg can be used to perform categorical regressi...

CatReg Software for Categorical Regression Analysis (Nov 2006)

EPA Science Inventory

CatReg is a computer program, written in the R (org">http://cran.r-project.org) programming language, to support the conduct of exposure-response analyses by toxicologists and health scientists. CatReg can be used to perform categorical regressi...

CATREG SOFTWARE FOR CATEGORICAL REGRESSION ANALYSIS

EPA Science Inventory

CatReg is a computer program, written in the R (org">http://cran.r-project.org) programming language, to support the conduct of exposure-response analyses by toxicologists and health scientists. CatReg can be used to perform categorical regressi...

CatReg Software for Categorical Regression Analysis (Feb 2011)

EPA Science Inventory

CatReg is a computer program, written in the R (org">http://cran.r-project.org) programming language, to support the conduct of exposure-response analyses by toxicologists and health scientists. CatReg can be used to perform categorical regressi...

The Command & Control of Aggregated Marine Expeditionary Units. Is Anyone Available Today?

DTIC Science & Technology

2013-04-11

Operations. 24 April 2012. https://ehqmc.usmc.mil/org/ ppo /pl/pln. 2. Personal correspondence or phone interviews with each command listed...and Operations. 24 April 2012. https://ehqmc.usmc.mil/org/ ppo /pl/pln. Stover 53 Congressional Budget Office. A CBO Study: An Analysis of the

10 CFR 431.323 - Materials incorporated by reference.

Code of Federal Regulations, 2010 CFR

2010-01-01

... W. 43rd Street, 4th Floor, New York, NY 10036, 212-642-4900, or go to http://www.ansi.org. (1) ANSI... Tracy Drive, Avon, MA 02322, 1-800-344-3555, or go to http://www.nfpa.org; (1) NFPA 70-2002 (“NFPA 70...

The Leaderless Social Movement Organization: Unstoppable Power or Last-Ditch Effort

DTIC Science & Technology

2010-12-01

Front Press Office Environmental Facts - GMOs ,” http://www.elfpressoffice.org/doa.html. 86 Leader and Probst, “The Earth Liberation Front and...Front Press Office Environmental Facts - GMOs .” Accessed November 22, 2009. http://www.elfpressoffice.org/doa.html. ———. “Earth Liberation Front

Shock from heart device often triggers further health care needs

MedlinePlus

... USA1 (242-8721) heart.org and strokeassociation.org Life is why , science is how . . . we help people live longer, healthier lives . What's Happening at AHA/ASA ${title} ... Featured Images Learn the two steps to help save a life! Hands-Only CPR has just two easy steps: ...

EnviroDIY ModularSensors: A Library to give Environmental Sensors a Common Interface of Functions for use with Arduino-Compatible Dataloggers

NASA Astrophysics Data System (ADS)

Aufdenkampe, A. K.; Damiano, S. G.; Hicks, S.; Horsburgh, J. S.

2017-12-01

EnviroDIY is a community for do-it-yourself environmental science and monitoring (https://envirodiy.org), largely focused on sharing ideas for developing Arduino-compatible open-source sensor stations, similar to the EnviroDIY Mayfly datalogger (http://envirodiy.org/mayfly/). Here we present the ModularSensors Arduino code library (https://github.com/EnviroDIY/ModularSensors), deisigned to give all sensors and variables a common interface of functions and returns and to make it very easy to iterate through and log data from many sensors and variables. This library was written primarily for the EnviroDIY Mayfly, but we have begun to test it on other Arduino based boards. We will show the large number of developed sensor interfaces, and examples of using this library code to stream near real time data to the new EnviroDIY Water Quality Data Portal (http://data.envirodiy.org/), a data and software system based on the Observations Data Model v2 (http://www.odm2.org).

Hydrography and biogeochemistry dedicated to the Mediterranean BGC-Argo network during a cruise with RV Tethys 2 in May 2015

NASA Astrophysics Data System (ADS)

Taillandier, Vincent; Wagener, Thibaut; D'Ortenzio, Fabrizio; Mayot, Nicolas; Legoff, Hervé; Ras, Joséphine; Coppola, Laurent; Pasqueron de Fommervault, Orens; Schmechtig, Catherine; Diamond, Emilie; Bittig, Henry; Lefevre, Dominique; Leymarie, Edouard; Poteau, Antoine; Prieur, Louis

2018-03-01

We report on data from an oceanographic cruise, covering western, central and eastern parts of the Mediterranean Sea, on the French research vessel Tethys 2 in May 2015. This cruise was fully dedicated to the maintenance and the metrological verification of a biogeochemical observing system based on a fleet of BGC-Argo floats. During the cruise, a comprehensive data set of parameters sensed by the autonomous network was collected. The measurements include ocean currents, seawater salinity and temperature, and concentrations of inorganic nutrients, dissolved oxygen and chlorophyll pigments. The analytical protocols and data processing methods are detailed, together with a first assessment of the calibration state for all the sensors deployed during the cruise. Data collected at stations are available at org/10.17882/51678" target="_blank">https://doi.org/10.17882/51678 and data collected along the ship track are available at org/10.17882/51691" target="_blank">https://doi.org/10.17882/51691.

A new subtype of progenitor cell in the mouse embryonic neocortex

PubMed Central

Wang, Xiaoqun; Tsai, Jin-Wu; LaMonica, Bridget; Kriegstein, Arnold R.

2011-01-01

A hallmark of mammalian brain evolution is cortical expansion, which reflects an increase in the number of cortical neurons established by the progenitor cell subtypes present and the number of their neurogenic divisions. Recent studies have revealed a new class of radial glia-like (oRG) progenitor cells in the human brain, which reside in the outer subventricular zone. Expansion of the subventricular zone and appearance of oRG cells may have been essential evolutionary steps leading from lissencephalic to gyrencephalic neocortex. Here we show that oRG-like progenitor cells are present in the mouse embryonic neocortex. They arise from asymmetric divisions of radial glia and undergo self-renewing asymmetric divisions to generate neurons. Moreover, mouse oRG cells undergo mitotic somal translocation whereby centrosome movement into the basal process during interphase preceeds nuclear translocation. Our finding of oRG cells in the developing rodent brain fills a gap in our understanding of neocortical expansion. PMID:21478886

New species of Cenozoic benthic foraminifera from the former British Petroleum micropalaeontology collection

NASA Astrophysics Data System (ADS)

Fox, Lyndsey R.; Stukins, Stephen; Hill, Tom; Bailey, Haydon

2018-01-01

This paper describes four new Cenozoic, deep-water benthic foraminifera from the reference collections at the Natural History Museum in London. The focus is on selected calcareous taxa that are of stratigraphical and/or palaeoecological significance for academic and industrial-related activities. Alabamina heyae (urn:lsid:zoobank.org:act:1E8A66E9-1F4C-4B61-BA97-6E0ECCD0173E), Nonion cepa (urn:lsid:zoobank.org:act:9F36350A-1E49-4D69-B2CC-C83F343E2952), Uvigerina kingi (urn:lsid:zoobank.org:act:C36C89C2-2E65-4FF6-9368-C169B4591995) and Lenticulina stewarti (urn:lsid:zoobank.org:act:485AE871-CECA-44E8-ABD1-BAE2961FFD59) are described with new illustrations. Their biostratigraphic and palaeoecological significance is briefly discussed.

Simultaneous Bioreduction of Multiple Oxidized Contaminants Using a Membrane Biofilm Reactor.

PubMed

Li, Haixiang; Lin, Hua; Xu, Xiaoyin; Jiang, Minmin; Chang, Chein-Chi; Xia, Siqing

2017-02-01

  This study tests a hydrogen-based membrane biofilm reactor (MBfR) to investigate simultaneous bioreduction of selected oxidized contaminants, including nitrate (org/1999/xlink" xlink:href="00178-ilm01.gif"/>-N), sulfate (org/1999/xlink" xlink:href="00178-ilm15.gif"/>), bromate (org/1999/xlink" xlink:href="00178-ilm26.gif"/>), chromate (Cr(VI)) and para-chloronitrobenzene (p-CNB). The experiments demonstrate that MBfR can achieve high performance for contaminants bioreduction to harmless or immobile forms in 240 days, with a maximum reduction fluxes of 0.901 g org/1999/xlink" xlink:href="00178-ilm37.gif"/>-N/m2·d, 1.573 g org/1999/xlink" xlink:href="00178-ilm48.gif"/>/m2·d, 0.009 g org/1999/xlink" xlink:href="00178-ilm59.gif"/>/m2·d, 0.022 g Cr(VI)/m2·d, and 0.043 g p-CNB/m2·d. Increasing H2 pressure and decreasing influent surface loading enhanced removal efficiency of the reactor. Flux analysis indicates that nitrate and sulfate reductions competed more strongly than org/1999/xlink" xlink:href="00178-ilm70.gif"/>, Cr(VI) and p-CNB reduction. The average H2 utilization rate, H2 flux, and H2 utilization efficiency of the reactor were 0.026 to 0.052 mg H2/cm3·d, 0.024 to 0.046 mg H2/cm2·d, and 97.5% to 99.3% (nearly 100%). Results show the hydrogen-based MBfR may be suitable for removing multiple oxidized contaminants in drinking water or groundwater.