LLNL NESHAPs 2015 Annual Report - June 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilson, K. R.; Gallegos, G. M.; MacQueen, D. H.

2016-06-01

Lawrence Livermore National Security, LLC operates facilities at Lawrence Livermore National Laboratory (LLNL) in which radionuclides are handled and stored. These facilities are subject to the U.S. Environmental Protection Agency (EPA) National Emission Standards for Hazardous Air Pollutants (NESHAPs) in Code of Federal Regulations (CFR) Title 40, Part 61, Subpart H, which regulates radionuclide emissions to air from Department of Energy (DOE) facilities. Specifically, NESHAPs limits the emission of radionuclides to the ambient air to levels resulting in an annual effective dose equivalent of 10 mrem (100 μSv) to any member of the public. Using measured and calculated emissions, andmore » building-specific and common parameters, LLNL personnel applied the EPA-approved computer code, CAP88-PC, Version 4.0.1.17, to calculate the dose to the maximally exposed individual member of the public for the Livermore Site and Site 300.« less

Hazardous-waste analysis plan for LLNL operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, R.S.

The Lawrence Livermore National Laboratory is involved in many facets of research ranging from nuclear weapons research to advanced Biomedical studies. Approximately 80% of all programs at LLNL generate hazardous waste in one form or another. Aside from producing waste from industrial type operations (oils, solvents, bottom sludges, etc.) many unique and toxic wastes are generated such as phosgene, dioxin (TCDD), radioactive wastes and high explosives. One key to any successful waste management program must address the following: proper identification of the waste, safe handling procedures and proper storage containers and areas. This section of the Waste Management Plan willmore » address methodologies used for the Analysis of Hazardous Waste. In addition to the wastes defined in 40 CFR 261, LLNL and Site 300 also generate radioactive waste not specifically covered by RCRA. However, for completeness, the Waste Analysis Plan will address all hazardous waste.« less

Lawrence Livermore National Laboratory Experimental Test Site (Site 300) Potable Water System Operations Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ocampo, Ruben P.; Bellah, Wendy

The existing Lawrence Livermore National Laboratory (LLNL) Site 300 drinking water system operation schematic is shown in Figures 1 and 2 below. The sources of water are from two Site 300 wells (Well #18 and Well #20) and San Francisco Public Utilities Commission (SFPUC) Hetch-Hetchy water through the Thomas shaft pumping station. Currently, Well #20 with 300 gallons per minute (gpm) pump capacity is the primary source of well water used during the months of September through July, while Well #18 with 225 gpm pump capacity is the source of well water for the month of August. The well watermore » is chlorinated using sodium hypochlorite to provide required residual chlorine throughout Site 300. Well water chlorination is covered in the Lawrence Livermore National Laboratory Experimental Test Site (Site 300) Chlorination Plan (“the Chlorination Plan”; LLNL-TR-642903; current version dated August 2013). The third source of water is the SFPUC Hetch-Hetchy Water System through the Thomas shaft facility with a 150 gpm pump capacity. At the Thomas shaft station the pumped water is treated through SFPUC-owned and operated ultraviolet (UV) reactor disinfection units on its way to Site 300. The Thomas Shaft Hetch- Hetchy water line is connected to the Site 300 water system through the line common to Well pumps #18 and #20 at valve box #1.« less

Report on the B-Fields at NIF Workshop Held at LLNL October 12-13, 2015

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fournier, K. B.; Moody, J. D.

2015-12-13

A national ICF laboratory workshop on requirements for a magnetized target capability on NIF was held by NIF at LLNL on October 12 and 13, attended by experts from LLNL, SNL, LLE, LANL, GA, and NRL. Advocates for indirect drive (LLNL), magnetic (Z) drive (SNL), polar direct drive (LLE), and basic science needing applied B (many institutions) presented and discussed requirements for the magnetized target capabilities they would like to see. 30T capability was most frequently requested. A phased operation increasing the field in steps experimentally can be envisioned. The NIF management will take the inputs from the scientific communitymore » represented at the workshop and recommend pulse-powered magnet parameters for NIF that best meet the collective user requests. In parallel, LLNL will continue investigating magnets for future generations that might be powered by compact laser-B-field generators (Moody, Fujioka, Santos, Woolsey, Pollock). The NIF facility engineers will start to analyze compatibility of the recommended pulsed magnet parameters (size, field, rise time, materials) with NIF chamber constraints, diagnostic access, and final optics protection against debris in FY16. The objective of this assessment will be to develop a schedule for achieving an initial Bfield capability. Based on an initial assessment, room temperature magnetized gas capsules will be fielded on NIF first. Magnetized cryo-ice-layered targets will take longer (more compatibility issues). Magnetized wetted foam DT targets (Olson) may have somewhat fewer compatibility issues making them a more likely choice for the first cryo-ice-layered target fielded with applied Bz.« less

LLNL Mercury Project Trinity Open Science Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brantley, Patrick; Dawson, Shawn; McKinley, Scott

2016-04-20

The Mercury Monte Carlo particle transport code developed at Lawrence Livermore National Laboratory (LLNL) is used to simulate the transport of radiation through urban environments. These challenging calculations include complicated geometries and require significant computational resources to complete. As a result, a question arises as to the level of convergence of the calculations with Monte Carlo simulation particle count. In the Trinity Open Science calculations, one main focus was to investigate convergence of the relevant simulation quantities with Monte Carlo particle count to assess the current simulation methodology. Both for this application space but also of more general applicability, wemore » also investigated the impact of code algorithms on parallel scaling on the Trinity machine as well as the utilization of the Trinity DataWarp burst buffer technology in Mercury via the LLNL Scalable Checkpoint/Restart (SCR) library.« less

LLNL electro-optical mine detection program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, C.; Aimonetti, W.; Barth, M.

1994-09-30

Under funding from the Advanced Research Projects Agency (ARPA) and the US Marine Corps (USMC), Lawrence Livermore National Laboratory (LLNL) has directed a program aimed at improving detection capabilities against buried mines and munitions. The program has provided a national test facility for buried mines in arid environments, compiled and distributed an extensive data base of infrared (IR), ground penetrating radar (GPR), and other measurements made at that site, served as a host for other organizations wishing to make measurements, made considerable progress in the use of ground penetrating radar for mine detection, and worked on the difficult problem ofmore » sensor fusion as applied to buried mine detection. While the majority of our effort has been concentrated on the buried mine problem, LLNL has worked with the U.S.M.C. on surface mine problems as well, providing data and analysis to support the COBRA (Coastal Battlefield Reconnaissance and Analysis) program. The original aim of the experimental aspect of the program was the utilization of multiband infrared approaches for the detection of buried mines. Later the work was extended to a multisensor investigation, including sensors other than infrared imagers. After an early series of measurements, it was determined that further progress would require a larger test facility in a natural environment, so the Buried Object Test Facility (BOTF) was constructed at the Nevada Test Site. After extensive testing, with sensors spanning the electromagnetic spectrum from the near ultraviolet to radio frequencies, possible paths for improvement were: improved spatial resolution providing better ground texture discrimination; analysis which involves more complicated spatial queueing and filtering; additional IR bands using imaging spectroscopy; the use of additional sensors other than IR and the use of data fusion techniques with multi-sensor data; and utilizing time dependent observables like temperature.« less

LLNL Results from CALIBAN-PROSPERO Nuclear Accident Dosimetry Experiments in September 2014

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lobaugh, M. L.; Hickman, D. P.; Wong, C. W.

2015-05-21

Lawrence Livermore National Laboratory (LLNL) uses thin neutron activation foils, sulfur, and threshold energy shielding to determine neutron component doses and the total dose from neutrons in the event of a nuclear criticality accident. The dosimeter also uses a DOELAP accredited Panasonic UD-810 (Panasonic Industrial Devices Sales Company of America, 2 Riverfront Plaza, Newark, NJ 07102, U.S.A.) thermoluminescent dosimetery system (TLD) for determining the gamma component of the total dose. LLNL has participated in three international intercomparisons of nuclear accident dosimeters. In October 2009, LLNL participated in an exercise at the French Commissariat à l’énergie atomique et aux énergies alternativesmore » (Alternative Energies and Atomic Energy Commission- CEA) Research Center at Valduc utilizing the SILENE reactor (Hickman, et.al. 2010). In September 2010, LLNL participated in a second intercomparison at CEA Valduc, this time with exposures at the CALIBAN reactor (Hickman et al. 2011). This paper discusses LLNL’s results of a third intercomparison hosted by the French Institut de Radioprotection et de Sûreté Nucléaire (Institute for Radiation Protection and Nuclear Safety- IRSN) with exposures at two CEA Valduc reactors (CALIBAN and PROSPERO) in September 2014. Comparison results between the three participating facilities is presented elsewhere (Chevallier 2015; Duluc 2015).« less

LLNL 10(a)(1)(A) Annual Report (TE-053672-2)--2005

DOE Office of Scientific and Technical Information (OSTI.GOV)

Woollett, J

2006-01-26

This report summarizes research related to Lawrence Livermore National Laboratory's (LLNL) Experimental Test Site, Site 300 (S300), located within Alameda and San Joaquin Counties (Figure 1) and conducted under the 10(a)(1)(A) (Recovery) permit TE-053672-2. This property is held in ownership by the U.S. Department of Energy/National Nuclear Security Administration (NNSA). The 2005 Recovery research at S300 involved fieldwork associated with only two species: Alameda whipsnake (Masticophis lateralis euryxanthus) and the California red-legged frog (Rana aurora draytonii) (RLF). Note: the whipsnake subspecies existing at S300 shows taxonomic variation (generally 50% chaparral whipsnake [Masticophis lateralis] traits) when compared to the Alameda whipsnakemore » (Riemer 1954) and therefore it will be referred to as ''California whipsnake (Masticophis lateralis)'' (CWS) for classification purposes in this report (Swaim 2004).« less

Review of LLNL Mixed Waste Streams for the Application of Potential Waste Reduction Controls

DOE Office of Scientific and Technical Information (OSTI.GOV)

Belue, A; Fischer, R P

2007-01-08

In July 2004, LLNL adopted the International Standard ISO 14001 as a Work Smart Standard in lieu of DOE Order 450.1. In support of this new requirement the Director issued a new environmental policy that was documented in Section 3.0 of Document 1.2, ''ES&H Policies of LLNL'', in the ES&H Manual. In recent years the Environmental Management System (EMS) process has become formalized as LLNL adopted ISO 14001 as part of the contract under which the laboratory is operated for the Department of Energy (DOE). On May 9, 2005, LLNL revised its Integrated Safety Management System Description to enhance existingmore » environmental requirements to meet ISO 14001. Effective October 1, 2005, each new project or activity is required to be evaluated from an environmental aspect, particularly if a potential exists for significant environmental impacts. Authorizing organizations are required to consider the management of all environmental aspects, the applicable regulatory requirements, and reasonable actions that can be taken to reduce negative environmental impacts. During 2006, LLNL has worked to implement the corrective actions addressing the deficiencies identified in the DOE/LSO audit. LLNL has begun to update the present EMS to meet the requirements of ISO 14001:2004. The EMS commits LLNL--and each employee--to responsible stewardship of all the environmental resources in our care. The generation of mixed radioactive waste was identified as a significant environmental aspect. Mixed waste for the purposes of this report is defined as waste materials containing both hazardous chemical and radioactive constituents. Significant environmental aspects require that an Environmental Management Plan (EMP) be developed. The objective of the EMP developed for mixed waste (EMP-005) is to evaluate options for reducing the amount of mixed waste generated. This document presents the findings of the evaluation of mixed waste generated at LLNL and a proposed plan for reduction.« less

Author Contribution to the Pu Handbook II: Chapter 37 LLNL Integrated Sample Preparation Glovebox (TEM) Section

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wall, Mark A.

The development of our Integrated Actinide Sample Preparation Laboratory (IASPL) commenced in 1998 driven by the need to perform transmission electron microscopy studies on naturally aged plutonium and its alloys looking for the microstructural effects of the radiological decay process (1). Remodeling and construction of a laboratory within the Chemistry and Materials Science Directorate facilities at LLNL was required to turn a standard radiological laboratory into a Radiological Materials Area (RMA) and Radiological Buffer Area (RBA) containing type I, II and III workplaces. Two inert atmosphere dry-train glove boxes with antechambers and entry/exit fumehoods (Figure 1), having a baseline atmospheremore » of 1 ppm oxygen and 1 ppm water vapor, a utility fumehood and a portable, and a third double-walled enclosure have been installed and commissioned. These capabilities, along with highly trained technical staff, facilitate the safe operation of sample preparation processes and instrumentation, and sample handling while minimizing oxidation or corrosion of the plutonium. In addition, we are currently developing the capability to safely transfer small metallographically prepared samples to a mini-SEM for microstructural imaging and chemical analysis. The gloveboxes continue to be the most crucial element of the laboratory allowing nearly oxide-free sample preparation for a wide variety of LLNL-based characterization experiments, which includes transmission electron microscopy, electron energy loss spectroscopy, optical microscopy, electrical resistivity, ion implantation, X-ray diffraction and absorption, magnetometry, metrological surface measurements, high-pressure diamond anvil cell equation-of-state, phonon dispersion measurements, X-ray absorption and emission spectroscopy, and differential scanning calorimetry. The sample preparation and materials processing capabilities in the IASPL have also facilitated experimentation at world-class facilities such as

2020 Foresight Forging the Future of Lawrence Livermore National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chrzanowski, P.

2000-01-01

The Lawrence Livermore National Laboratory (LLNL) of 2020 will look much different from the LLNL of today and vastly different from how it looked twenty years ago. We, the members of the Long-Range Strategy Project, envision a Laboratory not defined by one program--nuclear weapons research--but by several core programs related to or synergistic with LLNL's national security mission. We expect the Laboratory to be fully engaged with sponsors and the local community and closely partnering with other research and development (R&D) organizations and academia. Unclassified work will be a vital part of the Laboratory of 2020 and will visibly demonstratemore » LLNL's international science and technology strengths. We firmly believe that there will be a critical and continuing role for the Laboratory. As a dynamic and versatile multipurpose laboratory with a national security focus, LLNL will be applying its capabilities in science and technology to meet the needs of the nation in the 21st century. With strategic investments in science, outstanding technical capabilities, and effective relationships, the Laboratory will, we believe, continue to play a key role in securing the nation's future.« less

CDAC Student Report: Summary of LLNL Internship

DOE Office of Scientific and Technical Information (OSTI.GOV)

Herriman, Jane E.

Multiple objectives motivated me to apply for an internship at LLNL: I wanted to experience the work environment at a national lab, to learn about research and job opportunities at LLNL in particular, and to gain greater experience with code development, particularly within the realm of high performance computing (HPC). This summer I was selected to participate in LLNL's Computational Chemistry and Material Science Summer Institute (CCMS). CCMS is a 10 week program hosted by the Quantum Simulations group leader, Dr. Eric Schwegler. CCMS connects graduate students to mentors at LLNL involved in similar re- search and provides weekly seminarsmore » on a broad array of topics from within chemistry and materials science. Dr. Xavier Andrade and Dr. Erik Draeger served as my co-mentors over the summer, and Dr. Andrade continues to mentor me now that CCMS has concluded. Dr. Andrade is a member of the Quantum Simulations group within the Physical and Life Sciences at LLNL, and Dr. Draeger leads the HPC group within the Center for Applied Scientific Computing (CASC). The two have worked together to develop Qb@ll, an open-source first principles molecular dynamics code that was the platform for my summer research project.« less

Natural Language Processing as a Discipline at LLNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Firpo, M A

The field of Natural Language Processing (NLP) is described as it applies to the needs of LLNL in handling free-text. The state of the practice is outlined with the emphasis placed on two specific aspects of NLP: Information Extraction and Discourse Integration. A brief description is included of the NLP applications currently being used at LLNL. A gap analysis provides a look at where the technology needs work in order to meet the needs of LLNL. Finally, recommendations are made to meet these needs.

Laboratory Directed Research and Development FY2011 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Craig, W; Sketchley, J; Kotta, P

2012-03-22

A premier applied-science laboratory, Lawrence Livermore National Laboratory (LLNL) has earned the reputation as a leader in providing science and technology solutions to the most pressing national and global security problems. The LDRD Program, established by Congress at all DOE national laboratories in 1991, is LLNL's most important single resource for fostering excellent science and technology for today's needs and tomorrow's challenges. The LDRD internally directed research and development funding at LLNL enables high-risk, potentially high-payoff projects at the forefront of science and technology. The LDRD Program at Livermore serves to: (1) Support the Laboratory's missions, strategic plan, and foundationalmore » science; (2) Maintain the Laboratory's science and technology vitality; (3) Promote recruiting and retention; (4) Pursue collaborations; (5) Generate intellectual property; and (6) Strengthen the U.S. economy. Myriad LDRD projects over the years have made important contributions to every facet of the Laboratory's mission and strategic plan, including its commitment to nuclear, global, and energy and environmental security, as well as cutting-edge science and technology and engineering in high-energy-density matter, high-performance computing and simulation, materials and chemistry at the extremes, information systems, measurements and experimental science, and energy manipulation. A summary of each project was submitted by the principal investigator. Project summaries include the scope, motivation, goals, relevance to DOE/NNSA and LLNL mission areas, the technical progress achieved in FY11, and a list of publications that resulted from the research. The projects are: (1) Nuclear Threat Reduction; (2) Biosecurity; (3) High-Performance Computing and Simulation; (4) Intelligence; (5) Cybersecurity; (6) Energy Security; (7) Carbon Capture; (8) Material Properties, Theory, and Design; (9) Radiochemistry; (10) High-Energy-Density Science; (11) Laser

Status of experiments at LLNL on high-power X-band microwave generators

NASA Astrophysics Data System (ADS)

Houck, Timothy L.; Westenskow, Glen A.

1994-05-01

The Microwave Source Facility at the Lawrence Livermore National Laboratory (LLNL) is studying the application of induction accelerator technology to high-power microwave generators suitable for linear collider power sources. We report on the results of two experiments, both using the Choppertron's 11.4 GHz modulator and a 5-MeV, 1-kA induction beam. The first experimental configuration has a single traveling-wave output structure designed to produce in excess of 300 MW in a single fundamental waveguide. This output structure consists of 12 individual cells, the first two incorporating de-Q-ing circuits to dampen higher order resonant modes. The second experiment studies the feasibility of enhancing beam to microwave power conversion by accelerating a modulated beam with induction cells. Referred to as the `reacceleration experiment,' this experiment consists of three traveling-wave output structures designed to produce about 125 MW per output and two induction cells located between the outputs. Status of current and planned experiments are presented.

LLNL Partners with IBM on Brain-Like Computing Chip

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Essen, Brian

Lawrence Livermore National Laboratory (LLNL) will receive a first-of-a-kind brain-inspired supercomputing platform for deep learning developed by IBM Research. Based on a breakthrough neurosynaptic computer chip called IBM TrueNorth, the scalable platform will process the equivalent of 16 million neurons and 4 billion synapses and consume the energy equivalent of a hearing aid battery – a mere 2.5 watts of power. The brain-like, neural network design of the IBM Neuromorphic System is able to infer complex cognitive tasks such as pattern recognition and integrated sensory processing far more efficiently than conventional chips.

LLNL Partners with IBM on Brain-Like Computing Chip

ScienceCinema

Van Essen, Brian

2018-06-25

Lawrence Livermore National Laboratory (LLNL) will receive a first-of-a-kind brain-inspired supercomputing platform for deep learning developed by IBM Research. Based on a breakthrough neurosynaptic computer chip called IBM TrueNorth, the scalable platform will process the equivalent of 16 million neurons and 4 billion synapses and consume the energy equivalent of a hearing aid battery – a mere 2.5 watts of power. The brain-like, neural network design of the IBM Neuromorphic System is able to infer complex cognitive tasks such as pattern recognition and integrated sensory processing far more efficiently than conventional chips.

Simulating Afterburn with LLNL Hydrocodes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daily, L D

2004-06-11

Presented here is a working methodology for adapting a Lawrence Livermore National Laboratory (LLNL) developed hydrocode, ALE3D, to simulate weapon damage effects when afterburn is a consideration in the blast propagation. Experiments have shown that afterburn is of great consequence in enclosed environments (i.e. bomb in tunnel scenario, penetrating conventional munition in a bunker, or satchel charge placed in a deep underground facility). This empirical energy deposition methodology simulates the anticipated addition of kinetic energy that has been demonstrated by experiment (Kuhl, et. al. 1998), without explicitly solving the chemistry, or resolving the mesh to capture small-scale vorticity. This effortmore » is intended to complement the existing capability of either coupling ALE3D blast simulations with DYNA3D or performing fully coupled ALE3D simulations to predict building or component failure, for applications in National Security offensive strike planning as well as Homeland Defense infrastructure protection.« less

A Novel Approach to Semantic and Coreference Annotation at LLNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Firpo, M

A case is made for the importance of high quality semantic and coreference annotation. The challenges of providing such annotation are described. Asperger's Syndrome is introduced, and the connections are drawn between the needs of text annotation and the abilities of persons with Asperger's Syndrome to meet those needs. Finally, a pilot program is recommended wherein semantic annotation is performed by people with Asperger's Syndrome. The primary points embodied in this paper are as follows: (1) Document annotation is essential to the Natural Language Processing (NLP) projects at Lawrence Livermore National Laboratory (LLNL); (2) LLNL does not currently have amore » system in place to meet its need for text annotation; (3) Text annotation is challenging for a variety of reasons, many related to its very rote nature; (4) Persons with Asperger's Syndrome are particularly skilled at rote verbal tasks, and behavioral experts agree that they would excel at text annotation; and (6) A pilot study is recommend in which two to three people with Asperger's Syndrome annotate documents and then the quality and throughput of their work is evaluated relative to that of their neuro-typical peers.« less

Joint FAM/Line Management Assessment Report on LLNL Machine Guarding Safety Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Armstrong, J. J.

2016-07-19

The LLNL Safety Program for Machine Guarding is implemented to comply with requirements in the ES&H Manual Document 11.2, "Hazards-General and Miscellaneous," Section 13 Machine Guarding (Rev 18, issued Dec. 15, 2015). The primary goal of this LLNL Safety Program is to ensure that LLNL operations involving machine guarding are managed so that workers, equipment and government property are adequately protected. This means that all such operations are planned and approved using the Integrated Safety Management System to provide the most cost effective and safest means available to support the LLNL mission.

Lawrence Livermore National Laboratory Environmental Report 2010

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, H E; Bertoldo, N A; Campbell, C G

The purposes of the Lawrence Livermore National Laboratory Environmental Report 2010 are to record Lawrence Livermore National Laboratory's (LLNL's) compliance with environmental standards and requirements, describe LLNL's environmental protection and remediation programs, and present the results of environmental monitoring at the two LLNL sites - the Livermore site and Site 300. The report is prepared for the U.S. Department of Energy (DOE) by LLNL's Environmental Protection Department. Submittal of the report satisfies requirements under DOE Order 231.1A, Environmental Safety and Health Reporting, and DOE Order 5400.5, Radiation Protection of the Public and Environment. The report is distributed electronically and ismore » available at https://saer.llnl.gov/, the website for the LLNL annual environmental report. Previous LLNL annual environmental reports beginning in 1994 are also on the website. Some references in the electronic report text are underlined, which indicates that they are clickable links. Clicking on one of these links will open the related document, data workbook, or website that it refers to. The report begins with an executive summary, which provides the purpose of the report and an overview of LLNL's compliance and monitoring results. The first three chapters provide background information: Chapter 1 is an overview of the location, meteorology, and hydrogeology of the two LLNL sites; Chapter 2 is a summary of LLNL's compliance with environmental regulations; and Chapter 3 is a description of LLNL's environmental programs with an emphasis on the Environmental Management System including pollution prevention. The majority of the report covers LLNL's environmental monitoring programs and monitoring data for 2010: effluent and ambient air (Chapter 4); waters, including wastewater, storm water runoff, surface water, rain, and groundwater (Chapter 5); and terrestrial, including soil, sediment, vegetation, foodstuff, ambient radiation, and special

Laboratory directed research and development fy1999 annual report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Al-Ayat, R A

2000-04-11

The Lawrence Livermore National Laboratory (LLNL) was founded in 1952 and has been managed since its inception by the University of California (UC) for the U.S. Department of Energy (DOE). Because of this long association with UC, the Laboratory has been able to recruit a world-class workforce, establish an atmosphere of intellectual freedom and innovation, and achieve recognition in relevant fields of knowledge as a scientific and technological leader. This environment and reputation are essential for sustained scientific and technical excellence. As a DOE national laboratory with about 7,000 employees, LLNL has an essential and compelling primary mission to ensuremore » that the nation's nuclear weapons remain safe, secure, and reliable and to prevent the spread and use of nuclear weapons worldwide. The Laboratory receives funding from the DOE Assistant Secretary for Defense Programs, whose focus is stewardship of our nuclear weapons stockpile. Funding is also provided by the Deputy Administrator for Defense Nuclear Nonproliferation, many Department of Defense sponsors, other federal agencies, and the private sector. As a multidisciplinary laboratory, LLNL has applied its considerable skills in high-performance computing, advanced engineering, and the management of large research and development projects to become the science and technology leader in those areas of its mission responsibility. The Laboratory Directed Research and Development (LDRD) Program was authorized by the U.S. Congress in 1984. The Program allows the Director of each DOE laboratory to fund advanced, creative, and innovative research and development (R&D) activities that will ensure scientific and technical vitality in the continually evolving mission areas at DOE and the Laboratory. In addition, the LDRD Program provides LLNL with the flexibility to nurture and enrich essential scientific and technical competencies, which attract the most qualified scientists and engineers. The LDRD

Advanced Design Concepts for Dense Plasma Focus Devices at LLNL

NASA Astrophysics Data System (ADS)

Povilus, Alexander; Podpaly, Yuri; Cooper, Christopher; Shaw, Brian; Chapman, Steve; Mitrani, James; Anderson, Michael; Pearson, Aric; Anaya, Enrique; Koh, Ed; Falabella, Steve; Link, Tony; Schmidt, Andrea

2017-10-01

The dense plasma focus (DPF) is a z-pinch device where a plasma sheath is accelerated down a coaxial railgun and ends in a radial implosion, pinch phase. During the pinch phase, the plasma generates intense, transient electric fields through physical mechanisms, similar to beam instabilities, that can accelerate ions in the plasma sheath to MeV-scale energies on millimeter length scales. Using kinetic modeling techniques developed at LLNL, we have gained insight into the formation of these accelerating fields and are using these observations to optimize the behavior of the generated ion beam for producing neutrons via beam-target interactions for kilojoule to megajoule-scale devices. Using a set of DPF's, both in operation and in development at LLNL, we have explored critical aspects of these devices, including plasma sheath formation behavior, power delivery to the plasma, and instability seeding during the implosion in order to improve the absolute yield and stability of the device. Prepared by LLNL under Contract DE-AC52-07NA27344. Computing support for this work came from the LLNL Institutional Computing Grand Challenge program.

Control System for the LLNL Kicker Pulse Generator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Watson, J A; Anaya, R M; Cook, E G

2002-06-18

A solid-state high voltage pulse generator with multi-pulse burst capability, very fast rise and fall times, pulse width agility, and amplitude modulation capability for use with high speed electron beam kickers has been designed and tested at LLNL. A control system calculates a desired waveform to be applied to the kicker based on measured electron beam displacement then adjusts the pulse generators to provide the desired waveform. This paper presents the design of the control system and measure performance data from operation on the ETA-11 accelerator at LLNL.

Laboratory Directed Research and Development FY2001 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Al-Ayat, R

2002-06-20

Established by Congress in 1991, the Laboratory Directed Research and Development (LDRD) Program provides the Department of Energy (DOE)/National Nuclear Security Administration (NNSA) laboratories, like Lawrence Livermore National Laboratory (LLNL or the Laboratory), with the flexibility to invest up to 6% of their budget in long-term, high-risk, and potentially high payoff research and development (R&D) activities to support the DOE/NNSA's national security missions. By funding innovative R&D, the LDRD Program at LLNL develops and extends the Laboratory's intellectual foundations and maintains its vitality as a premier research institution. As proof of the Program's success, many of the research thrusts thatmore » started many years ago under LDRD sponsorship are at the core of today's programs. The LDRD Program, which serves as a proving ground for innovative ideas, is the Laboratory's most important single resource for fostering excellent science and technology for today's needs and tomorrow's challenges. Basic and applied research activities funded by LDRD enhance the Laboratory's core strengths, driving its technical vitality to create new capabilities that enable LLNL to meet DOE/NNSA's national security missions. The Program also plays a key role in building a world-class multidisciplinary workforce by engaging the Laboratory's best researchers, recruiting its future scientists and engineers, and promoting collaborations with all sectors of the larger scientific community.« less

Report on the Threatened Valley Elderberry Longhorn Beetle and its Elderberry Food Plant at the Lawrence Livermore National Laboratory--Site 300

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arnold, Ph.D., R A; Woollett, J

2004-11-16

This report describes the results of an entomological survey in 2002 to determine the presence of the federally-listed, threatened Valley Elderberry Longhorn Beetle or ''VELB'' (Desmocerus culifornicus dimorphus: Coleoptera, Cerambycidae) and its elderberry food plant (Sumbucus mexicana: Caprifoliaceae) on the Lawrence Livermore National Laboratory's (LLNL) Experimental Test Site, known as Site 300. In addition, an area located immediately southeast of Site 300, which is owned and managed by the California Department of Fish and Game (CDFG), but secured by LLNL, was also included in this survey. This report will refer to the survey areas as the LLNL-Site 300 and themore » CDFG site. The 2002 survey included mapping the locations of elderberry plants that were observed using a global positioning system (GPS) to obtain positional coordinates for every elderberry plant at Site 300. In addition, observations of VELB adults and signs of their infestation on elderberry plants were also mapped using GPS technology. LLNL requested information on the VELB and its elderberry food plants to update earlier information that had been collected in 1991 (Arnold 1991) as part of the 1992 EIS/EIR for continued operation of LLNL. No VELB adults were observed as part of this prior survey. The findings of the 2002 survey reported herein will be used by LLNL as it updates the expected 2004 Environmental Impact Statement for ongoing operations at LLNL, including Site 300.« less

Dielectronic Satellite Spectra of Na-like Mo Ions Benchmarked by LLNL EBIT with Application to HED Plasmas

NASA Astrophysics Data System (ADS)

Stafford, A.; Safronova, A. S.; Kantsyrev, V. L.; Safronova, U. I.; Petkov, E. E.; Shlyaptseva, V. V.; Childers, R.; Shrestha, I.; Beiersdorfer, P.; Hell, H.; Brown, G. V.

2017-10-01

Dielectronic recombination (DR) is an important process for astrophysical and laboratory high energy density (HED) plasmas and the associated satellite lines are frequently used for plasma diagnostics. In particular, K-shell DR satellite lines were studied in detail in low-Z plasmas. L-shell Na-like spectral features from Mo X-pinches considered here represent the blend of DR and inner shell satellites and motivated the detailed study of DR at the EBIT-1 electron beam ion trap at LLNL. In these experiments the beam energy was swept between 0.6 - 2.4 keV to produce resonances at certain electron beam energies. The advantages of using an electron beam ion trap to better understand atomic processes with highly ionized ions in HED Mo plasma are highlighted. This work was supported by NNSA under DOE Grant DE-NA0002954. Work at LLNL was performed under the auspices of the U.S. DOE under Contract No. DE-AC52-07NA27344.

Lawrence Livermore National Laboratory environmental report for 1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sims, J.M.; Surano, K.A.; Lamson, K.C.

1990-01-01

This report documents the results of the Environmental Monitoring Program at the Lawrence Livermore National Laboratory (LLNL) and presents summary information about environmental compliance for 1990. To evaluate the effect of LLNL operations on the local environment, measurements of direct radiation and a variety of radionuclides and chemical compounds in ambient air, soil, sewage effluent surface water, groundwater, vegetation, and foodstuff were made at both the Livermore site and at Site 300 nearly. LLNL's compliance with all applicable guides, standards, and limits for radiological and nonradiological emissions to the environment was evaluated. Aside from an August 13 observation of silvermore » concentrations slightly above guidelines for discharges to the sanitary sewer, all the monitoring data demonstrated LLNL compliance with environmental laws and regulations governing emission and discharge of materials to the environment. In addition, the monitoring data demonstrated that the environmental impacts of LLNL are minimal and pose no threat to the public to or to the environment. 114 refs., 46 figs., 79 tabs.« less

Laboratory Directed Research and Development FY 2000 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Al-Ayat, R

This Annual Report provides an overview of the FY2000 Laboratory Directed Research and Development (LDRD) Program at Lawrence Livermore National Laboratory (LLNL) and presents a summary of the results achieved by each project during the year.

Summary Statistics for Homemade ?Play Dough? -- Data Acquired at LLNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kallman, J S; Morales, K E; Whipple, R E

Using x-ray computerized tomography (CT), we have characterized the x-ray linear attenuation coefficients (LAC) of a homemade Play Dough{trademark}-like material, designated as PDA. Table 1 gives the first-order statistics for each of four CT measurements, estimated with a Gaussian kernel density estimator (KDE) analysis. The mean values of the LAC range from a high of about 2700 LMHU{sub D} 100kVp to a low of about 1200 LMHUD at 300kVp. The standard deviation of each measurement is around 10% to 15% of the mean. The entropy covers the range from 6.0 to 7.4. Ordinarily, we would model the LAC of themore » material and compare the modeled values to the measured values. In this case, however, we did not have the detailed chemical composition of the material and therefore did not model the LAC. Using a method recently proposed by Lawrence Livermore National Laboratory (LLNL), we estimate the value of the effective atomic number, Z{sub eff}, to be near 10. LLNL prepared about 50mL of the homemade 'Play Dough' in a polypropylene vial and firmly compressed it immediately prior to the x-ray measurements. We used the computer program IMGREC to reconstruct the CT images. The values of the key parameters used in the data capture and image reconstruction are given in this report. Additional details may be found in the experimental SOP and a separate document. To characterize the statistical distribution of LAC values in each CT image, we first isolated an 80% central-core segment of volume elements ('voxels') lying completely within the specimen, away from the walls of the polypropylene vial. All of the voxels within this central core, including those comprised of voids and inclusions, are included in the statistics. We then calculated the mean value, standard deviation and entropy for (a) the four image segments and for (b) their digital gradient images. (A digital gradient image of a given image was obtained by taking the absolute value of the difference between the

Astronomy Applications of Adaptive Optics at Lawrence Livermore National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bauman, B J; Gavel, D T

2003-04-23

Astronomical applications of adaptive optics at Lawrence Livermore National Laboratory (LLNL) has a history that extends from 1984. The program started with the Lick Observatory Adaptive Optics system and has progressed through the years to lever-larger telescopes: Keck, and now the proposed CELT (California Extremely Large Telescope) 30m telescope. LLNL AO continues to be at the forefront of AO development and science.

LLNL small-scale static spark machine: static spark sensitivity test

DOE Office of Scientific and Technical Information (OSTI.GOV)

Foltz, M F; Simpson, L R

1999-08-23

Small-scale safety testing of explosives and other energetic materials is done in order to determine their sensitivity to various stimuli, such as friction, static spark, and impact. Typically this testing is done to discover potential handling problems that may exist for either newly synthesized materials of unknown behavior, or materials that have been stored for long periods of time. This report describes the existing ''Static Spark Test Apparatus'' at Lawrence Livermore National Laboratory (LLNL), as well as the method used to evaluate the relative static spark sensitivity of energetic materials. The basic design, originally developed by the Picatinny Arsenal inmore » New Jersey, is discussed. The accumulated data for the materials tested to date is not included here, with the exception of specific examples that have yielded interesting or unusual results during the tests.« less

Historical Doses from Tritiated Water and Tritiated Hydrogen Gas Released to the Atmosphere from Lawrence Livermore National Laboratory (LLNL). Part 5. Accidental Releases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peterson, S

2007-08-15

Over the course of fifty-three years, LLNL had six acute releases of tritiated hydrogen gas (HT) and one acute release of tritiated water vapor (HTO) that were too large relative to the annual releases to be included as part of the annual releases from normal operations detailed in Parts 3 and 4 of the Tritium Dose Reconstruction (TDR). Sandia National Laboratories/California (SNL/CA) had one such release of HT and one of HTO. Doses to the maximally exposed individual (MEI) for these accidents have been modeled using an equation derived from the time-dependent tritium model, UFOTRI, and parameter values based onmore » expert judgment. All of these acute releases are described in this report. Doses that could not have been exceeded from the large HT releases of 1965 and 1970 were calculated to be 43 {micro}Sv (4.3 mrem) and 120 {micro}Sv (12 mrem) to an adult, respectively. Two published sets of dose predictions for the accidental HT release in 1970 are compared with the dose predictions of this TDR. The highest predicted dose was for an acute release of HTO in 1954. For this release, the dose that could not have been exceeded was estimated to have been 2 mSv (200 mrem), although, because of the high uncertainty about the predictions, the likely dose may have been as low as 360 {micro}Sv (36 mrem) or less. The estimated maximum exposures from the accidental releases were such that no adverse health effects would be expected. Appendix A lists all accidents and large routine puff releases that have occurred at LLNL and SNL/CA between 1953 and 2005. Appendix B describes the processes unique to tritium that must be modeled after an acute release, some of the time-dependent tritium models being used today, and the results of tests of these models.« less

Summary Report of Summer 2009 NGSI Human Capital Development Efforts at Lawrence Livermore National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dougan, A; Dreicer, M; Essner, J

2009-11-16

In 2009, Lawrence Livermore National Laboratory (LLNL) engaged in several activities to support NA-24's Next Generation Safeguards Initiative (NGSI). This report outlines LLNL's efforts to support Human Capital Development (HCD), one of five key components of NGSI managed by Dunbar Lockwood in the Office of International Regimes and Agreements (NA-243). There were five main LLNL summer safeguards HCD efforts sponsored by NGSI: (1) A joint Monterey Institute of International Studies/Center for Nonproliferation Studies-LLNL International Safeguards Policy and Information Analysis Course; (2) A Summer Safeguards Policy Internship Program at LLNL; (3) A Training in Environmental Sample Analysis for IAEA Safeguards Internship;more » (4) Safeguards Technology Internships; and (5) A joint LLNL-INL Summer Safeguards Lecture Series. In this report, we provide an overview of these five initiatives, an analysis of lessons learned, an update on the NGSI FY09 post-doc, and an update on students who participated in previous NGSI-sponsored LLNL safeguards HCD efforts.« less

National Ignition Facility: Experimental plan

NASA Astrophysics Data System (ADS)

1994-05-01

As part of the Conceptual Design Report (CDR) for the National Ignition Facility (NIF), scientists from Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), Sandia National Laboratory (SNL), the University of Rochester's Laboratory for Laser Energetics (UR/LLE), and EG&G formed an NIF Target Diagnostics Working Group. The purpose of the Target Diagnostics Working Group is to prepare conceptual designs of target diagnostics for inclusion in the facility CDR and to determine how these specifications impact the CDR. To accomplish this, a subgroup has directed its efforts at constructing an approximate experimental plan for the ignition campaign of the NIF CDR. The results of this effort are contained in this document, the Experimental Plan for achieving fusion ignition in the NIF. This group initially concentrated on the flow-down requirements of the experimental campaign leading to ignition, which will dominate the initial efforts of the NIF. It is envisaged, however, that before ignition, there will be parallel campaigns supporting weapons physics, weapons effects, and other research. This plan was developed by analyzing the sequence of activities required to finally fire the laser at the level of power and precision necessary to achieve the conditions of an ignition hohlraum target, and to then use our experience in activating and running Nova experiments to estimate the rate of completing these activities.

Summary Statistics for Fun Dough Data Acquired at LLNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kallman, J S; Morales, K E; Whipple, R E

Using x-ray computerized tomography (CT), we have characterized the x-ray linear attenuation coefficients (LAC) of a Play Dough{trademark}-like product, Fun Dough{trademark}, designated as PD. Table 1 gives the first-order statistics for each of four CT measurements, estimated with a Gaussian kernel density estimator (KDE) analysis. The mean values of the LAC range from a high of about 2100 LMHU{sub D} at 100kVp to a low of about 1100 LMHU{sub D} at 300kVp. The standard deviation of each measurement is around 1% of the mean. The entropy covers the range from 3.9 to 4.6. Ordinarily, we would model the LAC ofmore » the material and compare the modeled values to the measured values. In this case, however, we did not have the composition of the material and therefore did not model the LAC. Using a method recently proposed by Lawrence Livermore National Laboratory (LLNL), we estimate the value of the effective atomic number, Z{sub eff}, to be near 8.5. LLNL prepared about 50mL of the Fun Dough{trademark} in a polypropylene vial and firmly compressed it immediately prior to the x-ray measurements. Still, layers can plainly be seen in the reconstructed images, indicating that the bulk density of the material in the container is affected by voids and bubbles. We used the computer program IMGREC to reconstruct the CT images. The values of the key parameters used in the data capture and image reconstruction are given in this report. Additional details may be found in the experimental SOP and a separate document. To characterize the statistical distribution of LAC values in each CT image, we first isolated an 80% central-core segment of volume elements ('voxels') lying completely within the specimen, away from the walls of the polypropylene vial. All of the voxels within this central core, including those comprised of voids and inclusions, are included in the statistics. We then calculated the mean value, standard deviation and entropy for (a) the four image segments and

Laboratory directed research and development FY98 annual report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Al-Ayat, R; Holzrichter, J

1999-05-01

In 1984, Congress and the Department of Energy (DOE) established the Laboratory Directed Research and Development (LDRD) Program to enable the director of a national laboratory to foster and expedite innovative research and development (R and D) in mission areas. The Lawrence Livermore National Laboratory (LLNL) continually examines these mission areas through strategic planning and shapes the LDRD Program to meet its long-term vision. The goal of the LDRD Program is to spur development of new scientific and technical capabilities that enable LLNL to respond to the challenges within its evolving mission areas. In addition, the LDRD Program provides LLNLmore » with the flexibility to nurture and enrich essential scientific and technical competencies and enables the Laboratory to attract the most qualified scientists and engineers. The FY98 LDRD portfolio described in this annual report has been carefully structured to continue the tradition of vigorously supporting DOE and LLNL strategic vision and evolving mission areas. The projects selected for LDRD funding undergo stringent review and selection processes, which emphasize strategic relevance and require technical peer reviews of proposals by external and internal experts. These FY98 projects emphasize the Laboratory's national security needs: stewardship of the U.S. nuclear weapons stockpile, responsibility for the counter- and nonproliferation of weapons of mass destruction, development of high-performance computing, and support of DOE environmental research and waste management programs.« less

LLNL Scientists Use NERSC to Advance Global Aerosol Simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bergmann, D J; Chuang, C; Rotman, D

2004-10-13

While ''greenhouse gases'' have been the focus of climate change research for a number of years, DOE's ''Aerosol Initiative'' is now examining how aerosols (small particles of approximately micron size) affect the climate on both a global and regional scale. Scientists in the Atmospheric Science Division at Lawrence Livermore National Laboratory (LLNL) are using NERSC's IBM supercomputer and LLNL's IMPACT (atmospheric chemistry) model to perform simulations showing the historic effects of sulfur aerosols at a finer spatial resolution than ever done before. Simulations were carried out for five decades, from the 1950s through the 1990s. The results clearly show themore » effects of the changing global pattern of sulfur emissions. Whereas in 1950 the United States emitted 41 percent of the world's sulfur aerosols, this figure had dropped to 15 percent by 1990, due to conservation and anti-pollution policies. By contrast, the fraction of total sulfur emissions of European origin has only dropped by a factor of 2 and the Asian emission fraction jumped six fold during the same time, from 7 percent in 1950 to 44 percent in 1990. Under a special allocation of computing time provided by the Office of Science INCITE (Innovative and Novel Computational Impact on Theory and Experiment) program, Dan Bergmann, working with a team of LLNL scientists including Cathy Chuang, Philip Cameron-Smith, and Bala Govindasamy, was able to carry out a large number of calculations during the past month, making the aerosol project one of the largest users of NERSC resources. The applications ran on 128 and 256 processors. The objective was to assess the effects of anthropogenic (man-made) sulfate aerosols. The IMPACT model calculates the rate at which SO{sub 2} (a gas emitted by industrial activity) is oxidized and forms particles known as sulfate aerosols. These particles have a short lifespan in the atmosphere, often washing out in about a week. This means that their effects on climate

Supplement analysis for continued operation of Lawrence Livermore National Laboratory and Sandia National Laboratories, Livermore. Volume 2: Comment response document

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1999-03-01

The US Department of Energy (DOE), prepared a draft Supplement Analysis (SA) for Continued Operation of Lawrence Livermore National Laboratory (LLNL) and Sandia National Laboratories, Livermore (SNL-L), in accordance with DOE`s requirements for implementation of the National Environmental Policy Act of 1969 (NEPA) (10 Code of Federal Regulations [CFR] Part 1021.314). It considers whether the Final Environmental Impact Statement and Environmental Impact Report for Continued Operation of Lawrence Livermore National Laboratory and Sandia National Laboratories, Livermore (1992 EIS/EIR) should be supplement3ed, whether a new environmental impact statement (EIS) should be prepared, or no further NEPA documentation is required. The SAmore » examines the current project and program plans and proposals for LLNL and SNL-L, operations to identify new or modified projects or operations or new information for the period from 1998 to 2002 that was not considered in the 1992 EIS/EIR. When such changes, modifications, and information are identified, they are examined to determine whether they could be considered substantial or significant in reference to the 1992 proposed action and the 1993 Record of Decision (ROD). DOE released the draft SA to the public to obtain stakeholder comments and to consider those comments in the preparation of the final SA. DOE distributed copies of the draft SA to those who were known to have an interest in LLNL or SNL-L activities in addition to those who requested a copy. In response to comments received, DOE prepared this Comment Response Document.« less

Historic Context and Building Assessments for the Lawrence Livermore National Laboratory Built Environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ullrich, R. A.; Sullivan, M. A.

2007-09-14

This document was prepared to support u.s. Department of Energy / National Nuclear Security Agency (DOE/NNSA) compliance with Sections 106 and 110 of the National Historic Preservation Act (NHPA). Lawrence Livermore National Laboratory (LLNL) is a DOE/NNSA laboratory and is engaged in determining the historic status of its properties at both its main site in Livermore, California, and Site 300, its test site located eleven miles from the main site. LLNL contracted with the authors via Sandia National Laboratories (SNL) to prepare a historic context statement for properties at both sites and to provide assessments of those properties of potentialmore » historic interest. The report contains an extensive historic context statement and the assessments of individual properties and groups of properties determined, via criteria established in the context statement, to be of potential interest. The historic context statement addresses the four contexts within which LLNL falls: Local History, World War II History (WWII), Cold War History, and Post-Cold War History. Appropriate historic preservation themes relevant to LLNL's history are delineated within each context. In addition, thresholds are identified for historic significance within each of the contexts based on the explication and understanding of the Secretary of the Interior's Guidelines for determining eligibility for the National Register of Historic Places. The report identifies specific research areas and events in LLNL's history that are of interest and the portions of the built environment in which they occurred. Based on that discussion, properties of potential interest are identified and assessments of them are provided. Twenty individual buildings and three areas of potential historic interest were assessed. The final recommendation is that, of these, LLNL has five individual historic buildings, two sets of historic objects, and two historic districts eligible for the National Register. All are eligible

Serving the Nation for Fifty Years: 1952 - 2002 Lawrence Livermore National Laboratory [LLNL], Fifty Years of Accomplishments

DOE R&D Accomplishments Database

2002-01-01

For 50 years, Lawrence Livermore National Laboratory has been making history and making a difference. The outstanding efforts by a dedicated work force have led to many remarkable accomplishments. Creative individuals and interdisciplinary teams at the Laboratory have sought breakthrough advances to strengthen national security and to help meet other enduring national needs. The Laboratory's rich history includes many interwoven stories -- from the first nuclear test failure to accomplishments meeting today's challenges. Many stories are tied to Livermore's national security mission, which has evolved to include ensuring the safety, security, and reliability of the nation's nuclear weapons without conducting nuclear tests and preventing the proliferation and use of weapons of mass destruction. Throughout its history and in its wide range of research activities, Livermore has achieved breakthroughs in applied and basic science, remarkable feats of engineering, and extraordinary advances in experimental and computational capabilities. From the many stories to tell, one has been selected for each year of the Laboratory's history. Together, these stories give a sense of the Laboratory -- its lasting focus on important missions, dedication to scientific and technical excellence, and drive to made the world more secure and a better place to live.

Screening Program Reduced Melanoma Mortality at the Lawrence Livermore National Laboratory, 1984-1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schneider, MD, J S; II, PhD, D; MD, PhD, M

Worldwide incidence of cutaneous malignant melanoma has increased substantially, and no screening program has yet demonstrated reduction in mortality. We evaluated the education, self examination and targeted screening campaign at the Lawrence Livermore National Laboratory (LLNL) from its beginning in July 1984 through 1996. The thickness and crude incidence of melanoma from the years before the campaign were compared to those obtained during the 13 years of screening. Melanoma mortality during the 13-year period was based on a National Death Index search. Expected yearly deaths from melanoma among LLNL employees were calculated by using California mortality data matched by age,more » sex, and race/ethnicity and adjusted to exclude deaths from melanoma diagnosed before the program began or before employment at LLNL. After the program began, crude incidence of melanoma thicker than 0.75 mm decreased from 18 to 4 cases per 100,000 person-years (p = 0.02), while melanoma less than 0.75mm remained stable and in situ melanoma increased substantially. No eligible melanoma deaths occurred among LLNL employees during the screening period compared with a calculated 3.39 expected deaths (p = 0.034). Education, self examination and selective screening for melanoma at LLNL significantly decreased incidence of melanoma thicker than 0.75 mm and reduced the melanoma-related mortality rate to zero. This significant decrease in mortality rate persisted for at least 3 yr after employees retired or otherwise left the laboratory.« less

Evaluation of LLNL BSL-3 Maximum Credible Event Potential Consequence to the General Population and Surrounding Environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, M.

2010-08-16

The purpose of this evaluation is to establish reproducibility of the analysis and consequence results to the general population and surrounding environment in the LLNL Biosafety Level 3 Facility Environmental Assessment (LLNL 2008).

The EBIT Calorimeter Spectrometer: a new, permanent user facility at the LLNL EBIT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Porter, F S; Beiersdorfer, P; Brown, G V

The EBIT Calorimeter Spectrometer (ECS) is currently being completed and will be installed at the EBIT facility at the Lawrence Livermore National Laboratory in October 2007. The ECS will replace the smaller XRS/EBIT microcalorimeter spectrometer that has been in almost continuous operation since 2000. The XRS/EBIT was based on a spare laboratory cryostat and an engineering model detector system from the Suzaku/XRS observatory program. The new ECS spectrometer was built to be a low maintenance, high performance implanted silicon microcalorimeter spectrometer with 4 eV resolution at 6 keV, 32 detector channels, 10 {micro}s event timing, and capable of uninterrupted acquisitionmore » sessions of over 60 hours at 50 mK. The XRS/EBIT program has been very successful, producing many results on topics such as laboratory astrophysics, atomic physics, nuclear physics, and calibration of the spectrometers for the National Ignition Facility. The ECS spectrometer will continue this work into the future with improved spectral resolution, integration times, and ease-of-use. We designed the ECS instrument with TES detectors in mind by using the same highly successful magnetic shielding as our laboratory TES cryostats. This design will lead to a future TES instrument at the LLNL EBIT. Here we discuss the legacy of the XRS/EBIT program, the performance of the new ECS spectrometer, and plans for a future TES instrument.« less

Analyses in Support of Z-IFE: LLNL Progress Report for FY-04

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meier, W; Abbott, R; Latkowski, J

2004-10-06

During the last quarter of FY2004, Lawrence Livermore National Laboratory (LLNL) conducted a brief study of power plant options for a z-pinch-based inertial fusion energy (Z-IFE) power plant. Areas that were covered include chamber design, thick-liquid response, neutronics and activation, and systems studies. This report summarizes the progress made in each of these areas, provides recommendations for improvements to the basic design concept, and identifies future work that is needed. As a starting point to the LLNL studies, we have taken information provided in several publications and presentations. In particular, many of the basic parameters were taken from the ZP-3more » study, which is described in reference 4. The ZP-3 design called for 12 separate target chambers, with any 10 of them operating at a given time. Each chamber would be pulsed at a repetition rate of 0.1 Hz with a target yield of 3 GJ. Thus, each chamber would have a fusion power of 300 MW for a power plant total of 3000 MW. The ZP-3 study considered several options for the recyclable transmission lines (RTL). Early in the study, the LLNL group questioned the use of many chambers as well as the yield limitation of 3 GJ. The feeling was that a large number of chambers would invariably lead to a considerably higher system cost than for a system with fewer chambers. Naturally, this trend would be somewhat offset by the increased availability that might be possible with many chambers. Reference 4 points out that target yields as high as 20 GJ would be possible with currently available manufacturing technology. The LLNL team considered yields ranging from 3 to 20 GJ. Our findings indicate that higher yields, which lead one to fewer chambers, make the most sense from an economic point of view. Systems modeling, including relative economics, is covered in Section 2. Regardless of the number of chambers of the fusion yield per target, a Z-IFE power plant would make use of a thick-liquid wall protection

LLNL-G3Dv3: Global P wave tomography model for improved regional and teleseismic travel time prediction: LLNL-G3DV3---GLOBAL P WAVE TOMOGRAPHY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simmons, N. A.; Myers, S. C.; Johannesson, G.

[1] We develop a global-scale P wave velocity model (LLNL-G3Dv3) designed to accurately predict seismic travel times at regional and teleseismic distances simultaneously. The model provides a new image of Earth's interior, but the underlying practical purpose of the model is to provide enhanced seismic event location capabilities. The LLNL-G3Dv3 model is based on ∼2.8 millionP and Pnarrivals that are re-processed using our global multiple-event locator called Bayesloc. We construct LLNL-G3Dv3 within a spherical tessellation based framework, allowing for explicit representation of undulating and discontinuous layers including the crust and transition zone layers. Using a multiscale inversion technique, regional trendsmore » as well as fine details are captured where the data allow. LLNL-G3Dv3 exhibits large-scale structures including cratons and superplumes as well numerous complex details in the upper mantle including within the transition zone. Particularly, the model reveals new details of a vast network of subducted slabs trapped within the transition beneath much of Eurasia, including beneath the Tibetan Plateau. We demonstrate the impact of Bayesloc multiple-event location on the resulting tomographic images through comparison with images produced without the benefit of multiple-event constraints (single-event locations). We find that the multiple-event locations allow for better reconciliation of the large set of direct P phases recorded at 0–97° distance and yield a smoother and more continuous image relative to the single-event locations. Travel times predicted from a 3-D model are also found to be strongly influenced by the initial locations of the input data, even when an iterative inversion/relocation technique is employed.« less

Lawrence Livermore National Laboratory`s Computer Security Short Subjects Videos: Hidden Password, The Incident, Dangerous Games and The Mess; Computer Security Awareness Guide

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

A video on computer security is described. Lonnie Moore, the Computer Security Manager, CSSM/CPPM at Lawrence Livermore National Laboratory (LLNL) and Gale Warshawsky, the Coordinator for Computer Security Education and Awareness at LLNL, wanted to share topics such as computer ethics, software piracy, privacy issues, and protecting information in a format that would capture and hold an audience`s attention. Four Computer Security Short Subject videos were produced which ranged from 1--3 minutes each. These videos are very effective education and awareness tools that can be used to generate discussions about computer security concerns and good computing practices.

[The 1, 2, 3 of laboratory animal experimentation].

PubMed

Romero-Fernandez, Wilber; Batista-Castro, Zenia; De Lucca, Marisel; Ruano, Ana; García-Barceló, María; Rivera-Cervantes, Marta; García-Rodríguez, Julio; Sánchez-Mateos, Soledad

2016-06-01

The slow scientific development in Latin America in recent decades has delayed the incorporation of laboratory animal experimentation; however, this situation has started to change. Today, extraordinary scientific progress is evident, which has promoted the introduction and increased use of laboratory animals as an important tool for the advancement of biomedical sciences. In the aftermath of this boom, the need to provide the scientific community with training and guidance in all aspects related to animal experimentation has arisen. It is the responsibility of each country to regulate this practice, for both bioethical and legal reasons, to ensure consideration of the animals' rights and welfare. The following manuscript is the result of papers presented at the International Workshop on Laboratory Animal Testing held at the Technical University of Ambato, Ecuador; it contains information regarding the current state of affairs in laboratory animal testing and emphasizes critical aspects such as main species used, ethical and legal principles, and experimental and alternative designs for animal use. These works aim to ensure good practices that should define scientific work. This document will be relevant to both researchers who aim to newly incorporate animal testing into their research and those who seek to update their knowledge.

Progress Toward Measuring CO2 Isotopologue Fluxes in situ with the LLNL Miniature, Laser-based CO2 Sensor

NASA Astrophysics Data System (ADS)

Osuna, J. L.; Bora, M.; Bond, T.

2015-12-01

One method to constrain photosynthesis and respiration independently at the ecosystem scale is to measure the fluxes of CO2­ isotopologues. Instrumentation is currently available to makes these measurements but they are generally costly, large, bench-top instruments. Here, we present progress toward developing a laser-based sensor that can be deployed directly to a canopy to passively measure CO2 isotopologue fluxes. In this study, we perform initial proof-of-concept and sensor characterization tests in the laboratory and in the field to demonstrate performance of the Lawrence Livermore National Laboratory (LLNL) tunable diode laser flux sensor. The results shown herein demonstrate measurement of bulk CO2 as a first step toward achieving flux measurements of CO2 isotopologues. The sensor uses a Vertical Cavity Surface Emitting Laser (VCSEL) in the 2012 nm range. The laser is mounted in a multi-pass White Cell. In order to amplify the absorption signal of CO2 in this range we employ wave modulation spectroscopy, introducing an alternating current (AC) bias component where f is the frequency of modulation on the laser drive current in addition to the direct current (DC) emission scanning component. We observed a strong linear relationship (r2 = 0.998 and r2 = 0.978 at all and low CO2 concentrations, respectively) between the 2f signal and the CO2 concentration in the cell across the range of CO2 concentrations relevant for flux measurements. We use this calibration to interpret CO2 concentration of a gas flowing through the White cell in the laboratory and deployed over a grassy field. We will discuss sensor performance in the lab and in situ as well as address steps toward achieving canopy-deployed, passive measurements of CO2 isotopologue fluxes. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. LLNL-ABS-675788

An Interdisciplinary Laboratory to Teach Experimentation. Final Report.

ERIC Educational Resources Information Center

Schenck, Hilbert, Jr.

The author views the primary purpose of the modern engineering laboratory as teaching the student how to experiment. An attempt is made to update the engineering laboratory and make it generally meaningful for all students, whether headed for graduate school or an industrial job. The intent is to broaden the experimental picture so that students…

Multiple Drafts of Experimental Laboratory Reports.

ERIC Educational Resources Information Center

Sanford, James F.

Students could gain considerable insight into the philosophy and methods of scientific experimentation if instructors adopted procedures based on an understanding of and respect for writing as a process. Laboratory courses in psychology offer such an opportunity. These courses usually involve a heavy workload for both students and faculty, for, in…

Physical Science Laboratory Manual, Experimental Version.

ERIC Educational Resources Information Center

Cooperative General Science Project, Atlanta, GA.

Provided are physical science laboratory experiments which have been developed and used as a part of an experimental one year undergraduate course in general science for non-science majors. The experiments cover a limited number of topics representative of the scientific enterprise. Some of the topics are pressure and buoyancy, heat, motion,…

The National Ignition Facility (NIF) and High Energy Density Science Research at LLNL (Briefing Charts)

DTIC Science & Technology

2013-06-21

neutron activation detectors (FNADS) 2013-049951s2.ppt Detector locations • Average rR ~ 1 g/cm2 • ~ 50% variations Motivates new 2D backlit imaging...of the implosion Motivates Compton radiography for stagnated fuel shape g/cm2 DrR rR map from neutron Activation Detectors (90Zr(n,2n)  89Zr...high energy cosmic rays Oxford Univ./LLNL LLNL Novel phases of compressed diamond Synthesis of elements heavier than iron 1545 Neutron flux in

Advancing Your Career at LLNL: Meet NIF’s Radiation Control Technicians

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zarco, Judy; Gutierrez, Myrna; Beale, Richard

2017-04-26

Myrna Gutierrez and Judy Zarco took advantage of LLNL's legacy of encouraging continuing education to get the necessary degrees and training to advance their careers at the Lab. As Radiation Control Technicians, they help maintain safety at the National Ignition Facility.

Laboratory Directed Research and Development FY2010 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jackson, K J

2011-03-22

A premier applied-science laboratory, Lawrence Livermore National Laboratory (LLNL) has at its core a primary national security mission - to ensure the safety, security, and reliability of the nation's nuclear weapons stockpile without nuclear testing, and to prevent and counter the spread and use of weapons of mass destruction: nuclear, chemical, and biological. The Laboratory uses the scientific and engineering expertise and facilities developed for its primary mission to pursue advanced technologies to meet other important national security needs - homeland defense, military operations, and missile defense, for example - that evolve in response to emerging threats. For broader nationalmore » needs, LLNL executes programs in energy security, climate change and long-term energy needs, environmental assessment and management, bioscience and technology to improve human health, and for breakthroughs in fundamental science and technology. With this multidisciplinary expertise, the Laboratory serves as a science and technology resource to the U.S. government and as a partner with industry and academia. This annual report discusses the following topics: (1) Advanced Sensors and Instrumentation; (2) Biological Sciences; (3) Chemistry; (4) Earth and Space Sciences; (5) Energy Supply and Use; (6) Engineering and Manufacturing Processes; (7) Materials Science and Technology; Mathematics and Computing Science; (8) Nuclear Science and Engineering; and (9) Physics.« less

Lightning Protection System for HE Facilities at LLNL - Certification Template

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clancy, T J; Ong, M M; Brown, C G

2005-12-08

This document is meant as a template to assist in the development of your own lighting certification process. Aside from this introduction and the mock representative name of the building (Building A), this document is nearly identical to a lightning certification report issued by the Engineering Directorate at Lawrence Livermore National Laboratory. At the date of this release, we have certified over 70 HE processing and storage cells at our Site 300 facilities. In Chapters 1 and 2 respectively, we address the need and methods of lightning certification for HE processing and storage facilities at LLNL. We present the preferredmore » method of lightning protection in Chapter 3, as well as the likely building modifications that are needed to comply with this method. In Chapter 4, we present the threat assessment and resulting safe work areas within a cell. After certification, there may be changes to operations during a lightning alert, and this is discussed in Chapter 5. Chapter 6 lists the maintenance requirements for the continuation of lighting certification status. Appendices of this document are meant as an aid in developing your own certification process, and they include a bonding list, an inventory of measurement equipment, surge suppressors in use at LLNL, an Integrated Work and Safety form (IWS), and a template certification sign-off sheet. The lightning certification process involves more that what is spelled out in this document. The first steps involve considerable planning, the securing of funds, and management and explosives safety buy-in. Permits must be obtained, measurement equipment must be assembled and tested, and engineers and technicians must be trained in their use. Cursory building inspections are also recommended, and surge suppression for power systems must be addressed. Upon completion of a certification report and its sign-off by management, additional work is required. Training will be needed in order to educate workers and facility

PLACE: an open-source python package for laboratory automation, control, and experimentation.

PubMed

Johnson, Jami L; Tom Wörden, Henrik; van Wijk, Kasper

2015-02-01

In modern laboratories, software can drive the full experimental process from data acquisition to storage, processing, and analysis. The automation of laboratory data acquisition is an important consideration for every laboratory. When implementing a laboratory automation scheme, important parameters include its reliability, time to implement, adaptability, and compatibility with software used at other stages of experimentation. In this article, we present an open-source, flexible, and extensible Python package for Laboratory Automation, Control, and Experimentation (PLACE). The package uses modular organization and clear design principles; therefore, it can be easily customized or expanded to meet the needs of diverse laboratories. We discuss the organization of PLACE, data-handling considerations, and then present an example using PLACE for laser-ultrasound experiments. Finally, we demonstrate the seamless transition to post-processing and analysis with Python through the development of an analysis module for data produced by PLACE automation. © 2014 Society for Laboratory Automation and Screening.

LLNL Center of Excellence Work Items for Q9-Q10 period

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neely, J. R.

This work plan encompasses a slice of effort going on within the ASC program, and for projects utilizing COE vendor resources, describes work that will be performed by both LLNL staff and COE vendor staff collaboratively.

Fast Steering Mirror systems for the U-AVLIS program at LLNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Watson, J.; Avicola, K.; Payne, A.

1994-07-01

We have successfully deployed several fast steering mirror systems in the Uranium Atomic Vapor Isotope Separation (U-AVLIS) facility at LLNL. These systems employ 2 mm to 150 mm optics and piezoelectric actuators to achieve microradian pointing accuracy with disturbance rejection bandwidths to a few hundred hertz.

Experimenter's laboratory for visualized interactive science

NASA Technical Reports Server (NTRS)

Hansen, Elaine R.; Klemp, Marjorie K.; Lasater, Sally W.; Szczur, Marti R.; Klemp, Joseph B.

1992-01-01

The science activities of the 1990's will require the analysis of complex phenomena and large diverse sets of data. In order to meet these needs, we must take advantage of advanced user interaction techniques: modern user interface tools; visualization capabilities; affordable, high performance graphics workstations; and interoperable data standards and translator. To meet these needs, we propose to adopt and upgrade several existing tools and systems to create an experimenter's laboratory for visualized interactive science. Intuitive human-computer interaction techniques have already been developed and demonstrated at the University of Colorado. A Transportable Applications Executive (TAE+), developed at GSFC, is a powerful user interface tool for general purpose applications. A 3D visualization package developed by NCAR provides both color shaded surface displays and volumetric rendering in either index or true color. The Network Common Data Form (NetCDF) data access library developed by Unidata supports creation, access and sharing of scientific data in a form that is self-describing and network transparent. The combination and enhancement of these packages constitutes a powerful experimenter's laboratory capable of meeting key science needs of the 1990's. This proposal encompasses the work required to build and demonstrate this capability.

Experimenter's laboratory for visualized interactive science

NASA Technical Reports Server (NTRS)

Hansen, Elaine R.; Klemp, Marjorie K.; Lasater, Sally W.; Szczur, Marti R.; Klemp, Joseph B.

1993-01-01

The science activities of the 1990's will require the analysis of complex phenomena and large diverse sets of data. In order to meet these needs, we must take advantage of advanced user interaction techniques: modern user interface tools; visualization capabilities; affordable, high performance graphics workstations; and interoperatable data standards and translator. To meet these needs, we propose to adopt and upgrade several existing tools and systems to create an experimenter's laboratory for visualized interactive science. Intuitive human-computer interaction techniques have already been developed and demonstrated at the University of Colorado. A Transportable Applications Executive (TAE+), developed at GSFC, is a powerful user interface tool for general purpose applications. A 3D visualization package developed by NCAR provides both color-shaded surface displays and volumetric rendering in either index or true color. The Network Common Data Form (NetCDF) data access library developed by Unidata supports creation, access and sharing of scientific data in a form that is self-describing and network transparent. The combination and enhancement of these packages constitutes a powerful experimenter's laboratory capable of meeting key science needs of the 1990's. This proposal encompasses the work required to build and demonstrate this capability.

Production of High Harmonic X-ray Radiation from Non-linear Thomson Scattering at LLNL PLEIADES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lim, J; Doyuran, A; Frigola, P

2005-05-17

We describe an experiment for production of high harmonic x-ray radiation from Thomson backscattering of an ultra-short high power density laser by a relativistic electron beam at the PLEIADES facility at LLNL. In this scenario, electrons execute a ''figure-8'' motion under the influence of the high-intensity laser field, where the constant characterizing the field strength is expected to exceed unity: a{sub L} = eE{sub L}/m{sub e}cw{sub L} {ge} 1. With large a{sub L} this motion produces high harmonic x-ray radiation and significant broadening of the spectral peaks. This paper is intended to give a layout of the PLEIADES experiment, alongmore » with progress towards experimental goals.« less

Training and qualification of health and safety technicians at a national laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Egbert, W.F.; Trinoskey, P.A.

1994-10-01

Over the last 30 years, Lawrence Livermore National Laboratory (LLNL) has successfully implemented the concept of a multi-disciplined technician. LLNL Health and Safety Technicians have responsibilities in industrial hygiene, industrial safety, health physics, as well as fire, explosive, and criticality safety. One of the major benefits to this approach is the cost-effective use of workers who display an ownership of health and safety issues which is sometimes lacking when responsibilities are divided. Although LLNL has always promoted the concept of a multi-discipline technician, this concept is gaining interest within the Department of Energy (DOE) community. In November 1992, individuals frommore » Oak Ridge Institute of Science and Education (ORISE) and RUST Geotech, joined by LLNL established a committee to address the issues of Health and Safety Technicians. In 1993, the DOE Office of Environmental, Safety and Health, in response to the Defense Nuclear Facility Safety Board Recommendation 91-6, stated DOE projects, particularly environmental restoration, typically present hazards other than radiation such as chemicals, explosives, complex construction activities, etc., which require additional expertise by Radiological Control Technicians. They followed with a commitment that a training guide would be issued. The trend in the last two decades has been toward greater specialization in the areas of health and safety. In contrast, the LLNL has moved toward a generalist approach integrating the once separate functions of the industrial hygiene and health physics technician into one function.« less

Transition-ready technologies and expertise from the Chemical and Biological National Security Program at LLNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Folta, P A; McBride, M T

2006-02-22

HSARPA has initiated a new Bioinformatics and Assay Development solicitation, BIAD2 (BAA 06-01), to address a number of technology gaps and requirements for biodetection (www.hsarpabaa.com). This solicitation will leverage the vast research and development capabilities of the private sector and academia in order to meet the needs of HSARPA and Homeland Security. In order to meet these requirements, this solicitation will: (1) Develop and validate actionable assays for the public and private sector; (2) Develop and validate new assays and novel assay methodologies to enhance existing detection systems and enable future detection platforms; (3) Develop next generation assays which aremore » robust against novel, emerging and engineered threats; (4) Develop novel assays that detect low levels of ribonucleic acid (RNA)-based viral threats in complex backgrounds; (5) Develop novel assays to characterize the viability, degree of virulence or toxicity, and countermeasure resistance of a biological agent; and (6) Develop new bioinformatics tools to support assay development and assay validation The Lawrence Livermore National Laboratory (LLNL) Bioassays and Signature Program (BSP) develops nationally-validated detection and identification assays to cover the full range of biological threat agents, starting from human, animal, and plant pathogens on the Select Agent list. The assays that have been co-developed by the CDC and the BSP are used internationally and represent the gold standard for molecular detection of select agent pathogens for the public health community. They are also used in the DHS environmental monitoring operations such as BioWatch and DHS National Security Special Events support. These reagents have been used to process and analyze more than 5 million samples and have delivered exceptional performance for the end users, with zero false positives since their deployment. Currently, highly-multiplexed nucleic acid assays that represent the ''next

Code Verification Results of an LLNL ASC Code on Some Tri-Lab Verification Test Suite Problems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, S R; Bihari, B L; Salari, K

As scientific codes become more complex and involve larger numbers of developers and algorithms, chances for algorithmic implementation mistakes increase. In this environment, code verification becomes essential to building confidence in the code implementation. This paper will present first results of a new code verification effort within LLNL's B Division. In particular, we will show results of code verification of the LLNL ASC ARES code on the test problems: Su Olson non-equilibrium radiation diffusion, Sod shock tube, Sedov point blast modeled with shock hydrodynamics, and Noh implosion.

Special Analysis for the Disposal of the Lawrence Livermore National Laboratory EnergyX Macroencapsulated Waste Stream at the Area 5 Radioactive Waste Management Site, Nevada National Security Site, Nye County, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shott, Gregory J.

This special analysis (SA) evaluates whether the Lawrence Livermore National Laboratory (LLNL) EnergyX Macroencapsulated waste stream (B LAMACRONCAP, Revision 1) is suitable for disposal by shallow land burial (SLB) at the Area 5 Radioactive Waste Management Site (RWMS) at the Nevada National Security Site (NNSS). The LLNL EnergyX Macroencapsulated waste stream is macroencapsulated mixed waste generated during research laboratory operations and maintenance (LLNL 2015). The LLNL EnergyX Macroencapsulated waste stream required a special analysis due to tritium (3H), cobalt-60 (60Co), cesium-137 (137Cs), and radium-226 (226Ra) exceeding the NNSS Waste Acceptance Criteria (WAC) Action Levels (U.S. Department of Energy, National Nuclearmore » Security Administration Nevada Field Office [NNSA/NFO] 2015).The results indicate that all performance objectives can be met with disposal of the waste stream in a SLB trench. Addition of the LLNL EnergyX Macroencapsulated inventory slightly increases multiple performance assessment results, with the largest relative increase occurring for the all-pathways annual total effective dose (TED). The maximum mean and 95th percentile 222Rn flux density remain less than the performance objective throughout the compliance period. The LLNL EnergyX Macroencapsulated waste stream is suitable for disposal by SLB at the Area 5 RWMS. The waste stream is recommended for approval without conditions.« less

The EBIT Calorimeter Spectrometer: A New, Permanent User Facility at the LLNL EBIT

NASA Technical Reports Server (NTRS)

Porter, S.

2007-01-01

The EBIT Calorimeter Spectrometer (ECS) has recently been completed and is currently being installed at the EBIT facility at the Lawrence Livermore National Laboratory. The ECS will replace the smaller XRS/EBIT spectrometer that has been in almost continuous operation since 2000. The XRS/EBIT was based on a spare laboratory cryostat and an engineering model detector system from the Suzaku/XRS observatory. The new ECS spectrometer was built from the ground up to be a low maintenance, high performance microcalorimeter spectrometer with 4 eV resolution at 6 keV, 32 detector channels, 10 us event timing, and capable of uninterrupted acquisition sessions of over 70 hours at 50 mK. The XRSIEBIT program has been extremely successful, producing over two-dozen refereed publications on topics such as laboratory astrophysics, atomic physics, nuclear physics, and calibration of the spectrometers for the National Ignition Facility, with many more publications in preparation. The ECS spectrometer will continue this work into the future with improved spectral resolution, integration times, and ease-of-use. We designed the ECS instrument with TES detectors in mind by using the same highly successful magnetic shielding as our laboratory TES cryostats. This design will lead to a future TES instrument at the LLNL EBIT. This proposed future instrument would include a hybrid detector system with 0.8 eV resolution in the band from 0.1-1.0 keV, 2 eV from 0.1-10 keV, and 30 eV from 0.5-100 keV, with high quantum efficiency in each band. Here we discuss the legacy of the XRS/EBIT program, the performance of the new ECS spectrometer, and plans for a future TES spectrometer.

Lawrence Livermore National Laboratory Safeguards and Security quarterly progress report to the US Department of Energy: Quarter ending December 31, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, G.; Mansur, D.L.; Ruhter, W.D.

1994-01-01

The Lawrence Livermore National Laboratory (LLNL) carries out safeguards and security activities for the Department of Energy (DOE), Office of Safeguards and Security (OSS), as well as other organizations, both within and outside the DOE. This document summarizes the activities conducted for the OSS during the first quarter of fiscal year 1994 (October through December, 1993). The nature and scope of the activities carried out for OSS at LLNL require a broad base of technical expertise. To assure projects are staffed and executed effectively, projects are conducted by the organization at LLNL best able to supply the needed technical expertise.more » These projects are developed and managed by senior program managers. Institutional oversight and coordination is provided through the LLNL Deputy Director`s office. At present, the Laboratory is supporting OSS in five areas: (1) Safeguards Technology, (2) Safeguards and Decision Support, (3) Computer Security, (4) DOE Automated Physical Security, and (5) DOE Automated Visitor Access Control System. This report describes the activities in each of these five areas. The information provided includes an introduction which briefly describes the activity, summary of major accomplishments, task descriptions with quarterly progress, summaries of milestones and deliverables and publications published this quarter.« less

LLNL Radiation Protection Program (RPP) Rev 9.2, Implementation of 10 CFR 835, 'Occupational Radiation Protection'

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shingleton, K. L.

2011-06-15

The Department of Energy (DOE) originally issued Part 10 CFR 835, Occupational Radiation Protection, on January 1, 1994. This regulation, hereafter referred to as “the Rule”, required DOE contractors to develop and maintain a DOE-approved Radiation Protection Program (RPP); DOE approved the initial Lawrence Livermore National Laboratory (LLNL) RPP (Rev 2) on 6/29/95. DOE issued a revision to the Rule on December 4, 1998 and approved LLNL’s revised RPP (Rev 7.1) on 11/18/99. DOE issued a second Rule revision on June 8, 2007 (effective July 9, 2007) and on June 13, 2008 approved LLNL’s RPP (Rev 9.0) which contained plansmore » and measures for coming into compliance with the 2007 Rule changes. DOE issued a correction to the Rule on April 21, 2009.« less

[Improving experimental teaching facilities and opening up of laboratories in order to raise experimental teaching quality of genetics].

PubMed

Xiao, Jian-Fu; Wu, Jian-Guo; Shi, Chun-Hai

2011-12-01

Advanced teaching facilities and the policy of opening laboratories to students play an important role in raising the quality in the experimental teaching of Genetics. This article introduces the superiority of some advanced instruments and equipment (such as digital microscope mutual laboratory system, flow cytometry, and NIRSystems) in the experimental teaching of genetics, and illustrates with examples the significance of exposing students to experiments in developing their creative consciousness and creative ability. This article also offers some new concepts on the further improvement upon teaching in the laboratory.

Lawrence Livermore National Laboratory safeguards and security quarterly progress report to the U.S. Department of Energy. Quarter ending December 31, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, G.; Mansur, D.L.; Ruhter, W.D.

The Lawrence Livermore National Laboratory (LLNL) carries out safeguards and security activities for the Department of Energy (DOE), Office of Safeguards and Security (OSS), as well as other organizations, both within and outside the DOE. This document summarizes the activities conducted for the OSS during the First Quarter of Fiscal Year 1997 (October through December, 1996). The nature and scope of the activities carried out for OSS at LLNL require a broad base of technical expertise. To assure projects are staffed and executed effectively, projects are conducted by the organization at LLNL best able to supply the needed technical expertise.more » These projects are developed and managed by senior program managers. Institutional oversight and coordination is provided through the LLNL Deputy Director`s office. At present, the Laboratory is supporting OSS in four areas: (1) safeguards technology; (2) safeguards and material accountability; (3) computer security--distributed systems; and (4) physical and personnel security support. The remainder of this report describes the activities in each of these four areas. The information provided includes an introduction which briefly describes the activity, summary of major accomplishments, task descriptions with quarterly progress, summaries of milestones and deliverables and publications published this quarter.« less

Experimental encephalomyocarditis virus infection in small laboratory rodents.

PubMed

Doi, K

2011-01-01

Encephalomyocarditis virus (EMCV) is a cardiovirus that belongs to the family Picornaviridae. EMCV is an important cause of acute myocarditis in piglets and of fetal death or abortion in pregnant sows. Small rodents, especially rats, have been suspected to be reservoir hosts or carriers. This virus also induces type 1 diabetes mellitus, encephalomyelitis, myocarditis, orchitis and/or sialodacryoadenitis in small laboratory rodents. This paper reviews the pathology and pathogenesis of experimental infection with EMCV in small laboratory rodents. Copyright © 2010 Elsevier Ltd. All rights reserved.

Java Performance for Scientific Applications on LLNL Computer Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kapfer, C; Wissink, A

2002-05-10

Languages in use for high performance computing at the laboratory--Fortran (f77 and f90), C, and C++--have many years of development behind them and are generally considered the fastest available. However, Fortran and C do not readily extend to object-oriented programming models, limiting their capability for very complex simulation software. C++ facilitates object-oriented programming but is a very complex and error-prone language. Java offers a number of capabilities that these other languages do not. For instance it implements cleaner (i.e., easier to use and less prone to errors) object-oriented models than C++. It also offers networking and security as part ofmore » the language standard, and cross-platform executables that make it architecture neutral, to name a few. These features have made Java very popular for industrial computing applications. The aim of this paper is to explain the trade-offs in using Java for large-scale scientific applications at LLNL. Despite its advantages, the computational science community has been reluctant to write large-scale computationally intensive applications in Java due to concerns over its poor performance. However, considerable progress has been made over the last several years. The Java Grande Forum [1] has been promoting the use of Java for large-scale computing. Members have introduced efficient array libraries, developed fast just-in-time (JIT) compilers, and built links to existing packages used in high performance parallel computing.« less

EBIT - Electronic Beam Ion Trap: N Divison experimental physics annual report 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schneider, D.

1996-10-01

The multi-faceted research effort of the EBIT (Electron Beam Ion Trap) program in N-Division of the Physics and Space Technology Department at Lawrence Livermore National Laboratory (LLNL) continues to contribute significant results to the physical sciences from studies with low energy very highly charged heavy ions. The EBIT program attracts a number of collaborators from the US and abroad for the different projects. The collaborations are partly carried out through participating graduate students demonstrating the excellent educational capabilities at the LLNL EBIT facilities. Moreover, participants from Historically Black Colleges and Universities are engaged in the EBIT project. This report describesmore » EBIT work for 1995 in atomic structure measurements and radiative transition probabilities, spectral diagnostics for laboratory and astrophysical plasmas, ion/surface interaction studies, electron-ion interactions studies, retrap and ion collisions, and instrumental development.« less

Ferrenberg Swendsen Analysis of LLNL and NYBlue BG/L p4rhms Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soltz, R

2007-12-05

These results are from the continuing Lattice Quantum Chromodynamics runs on BG/L. These results are from the Ferrenberg-Swendsen analysis [?] of the combined data from LLNL and NYBlue BG/L runs for 32{sup 3} x 8 runs with the p4rhmc v2.0 QMP-MPI.X (semi-optimized p4 code using qmp over mpi). The jobs include beta values ranging from 3.525 to 3.535 with an alternate analysis extending to 3.540. The NYBlue data sets are from 9k trajectories from Oct 2007, and the LLNL data are from two independent streams of {approx}5k each, taking from the July 2007 runs. The following outputs are produced bymore » the fs-2+1-chiub.c program. All outputs have had checksums produced by addCks.pl and checked by the checkCks.pl perl script after scanning.« less

Selected results from LLNL-Hughes RAR for West Coast Scotland Experiment 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lehman, S.K.; Johnston, B.; Twogood, R.

1993-01-05

The joint US-UK 1992 West Coast Scotland Experiment (WCSEX) was held in the Sound of Sleat from June 6 to 25. The LLNL-Hughes team fielded a fully polarimetric X-band hill-side real aperture radar to collect internal wave wake data. We present here a sample data set of the best radar runs.

Guided Inquiry in a Biochemistry Laboratory Course Improves Experimental Design Ability

ERIC Educational Resources Information Center

Goodey, Nina M.; Talgar, Cigdem P.

2016-01-01

Many biochemistry laboratory courses expose students to laboratory techniques through pre-determined experiments in which students follow stepwise protocols provided by the instructor. This approach fails to provide students with sufficient opportunities to practice experimental design and critical thinking. Ten inquiry modules were created for a…

Optimizing laboratory animal stress paradigms: The H-H* experimental design.

PubMed

McCarty, Richard

2017-01-01

Major advances in behavioral neuroscience have been facilitated by the development of consistent and highly reproducible experimental paradigms that have been widely adopted. In contrast, many different experimental approaches have been employed to expose laboratory mice and rats to acute versus chronic intermittent stress. An argument is advanced in this review that more consistent approaches to the design of chronic intermittent stress experiments would provide greater reproducibility of results across laboratories and greater reliability relating to various neural, endocrine, immune, genetic, and behavioral adaptations. As an example, the H-H* experimental design incorporates control, homotypic (H), and heterotypic (H*) groups and allows for comparisons across groups, where each animal is exposed to the same stressor, but that stressor has vastly different biological and behavioral effects depending upon each animal's prior stress history. Implementation of the H-H* experimental paradigm makes possible a delineation of transcriptional changes and neural, endocrine, and immune pathways that are activated in precisely defined stressor contexts. Copyright © 2016 Elsevier Ltd. All rights reserved.

Laboratory Data for X-Ray Astronomy

NASA Technical Reports Server (NTRS)

Beiersdorfer, P.; Brown, G. V.; Chen, H.; Gu, M.-F.; Kahn, S. M.; Lepson, J. K.; Savin, D. W.; Utter, S. B.

2000-01-01

Laboratory facilities have made great strides in producing large sets of reliable data for X-ray astronomy, which include ionization and recombination cross sections needed for charge balance calculations as well as the atomic data needed for interpreting X-ray line formation. We discuss data from the new generation sources and pay special attention to the LLNL electron beam ion trap experiment, which is unique in its ability to provide direct laboratory access to spectral data under precisely controlled conditions that simulate those found in many astrophysical plasmas. Examples of spectral data obtained in the 1-160 A wavelength range are given illustrating the type of laboratory X-ray data produced in support of such missions as Chandra, X-Ray Multi-Mirror telescope (XMM), Advanced Satellite for Cosmology and Astrophysics (ASCA) and Extreme Ultraviolet Explorer Satellite (EUVE).

Precision and manufacturing at the Lawrence Livermore National Laboratory

NASA Technical Reports Server (NTRS)

Saito, Theodore T.; Wasley, Richard J.; Stowers, Irving F.; Donaldson, Robert R.; Thompson, Daniel C.

1994-01-01

Precision Engineering is one of the Lawrence Livermore National Laboratory's core strengths. This paper discusses the past and present current technology transfer efforts of LLNL's Precision Engineering program and the Livermore Center for Advanced Manufacturing and Productivity (LCAMP). More than a year ago the Precision Machine Commercialization project embodied several successful methods of transferring high technology from the National Laboratories to industry. Currently, LCAMP has already demonstrated successful technology transfer and is involved in a broad spectrum of current programs. In addition, this paper discusses other technologies ripe for future transition including the Large Optics Diamond Turning Machine.

Precision and manufacturing at the Lawrence Livermore National Laboratory

NASA Astrophysics Data System (ADS)

Saito, Theodore T.; Wasley, Richard J.; Stowers, Irving F.; Donaldson, Robert R.; Thompson, Daniel C.

1994-02-01

Precision Engineering is one of the Lawrence Livermore National Laboratory's core strengths. This paper discusses the past and present current technology transfer efforts of LLNL's Precision Engineering program and the Livermore Center for Advanced Manufacturing and Productivity (LCAMP). More than a year ago the Precision Machine Commercialization project embodied several successful methods of transferring high technology from the National Laboratories to industry. Currently, LCAMP has already demonstrated successful technology transfer and is involved in a broad spectrum of current programs. In addition, this paper discusses other technologies ripe for future transition including the Large Optics Diamond Turning Machine.

Experimenter's Laboratory for Visualized Interactive Science

NASA Technical Reports Server (NTRS)

Hansen, Elaine R.; Rodier, Daniel R.; Klemp, Marjorie K.

1994-01-01

ELVIS (Experimenter's Laboratory for Visualized Interactive Science) is an interactive visualization environment that enables scientists, students, and educators to visualize and analyze large, complex, and diverse sets of scientific data. It accomplishes this by presenting the data sets as 2-D, 3-D, color, stereo, and graphic images with movable and multiple light sources combined with displays of solid-surface, contours, wire-frame, and transparency. By simultaneously rendering diverse data sets acquired from multiple sources, formats, and resolutions and by interacting with the data through an intuitive, direct-manipulation interface, ELVIS provides an interactive and responsive environment for exploratory data analysis.

Lawrence Livermore National Laboratories Perspective on Code Development and High Performance Computing Resources in Support of the National HED/ICF Effort

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clouse, C. J.; Edwards, M. J.; McCoy, M. G.

2015-07-07

Through its Advanced Scientific Computing (ASC) and Inertial Confinement Fusion (ICF) code development efforts, Lawrence Livermore National Laboratory (LLNL) provides a world leading numerical simulation capability for the National HED/ICF program in support of the Stockpile Stewardship Program (SSP). In addition the ASC effort provides high performance computing platform capabilities upon which these codes are run. LLNL remains committed to, and will work with, the national HED/ICF program community to help insure numerical simulation needs are met and to make those capabilities available, consistent with programmatic priorities and available resources.

Installation of hybrid ion source on the 1-MV LLNL BioAMS spectrometer

PubMed Central

Ognibene, T. J.; Salazar, G. A.

2012-01-01

A second ion source was recently installed onto the LLNL 1-MV AMS spectrometer, which is dedicated to the quantification of 14C and 3H within biochemical samples. This source is unique among the other LLNL cesium sputter ion sources in that it can ionize both gaseous and solid samples. Also, the injection beam line has been designed to directly measure 14C/12C isotope ratios without the need for electrostatic bouncing. Preliminary tests show that this source can ionize transient CO2 gas pulses containing less than 1 ug carbon with approximately 1.5% efficiency. We demonstrate that the measured 14C/12C isotope ratio is largely unaffected by small drifts in the argon stripper gas density. We also determine that a tandem accelerating voltage of 670 kV enables the highest 14C transmission through the system. Finally, we describe a series of performance tests using solid graphite targets spanning nearly 3 orders in magnitude dynamic range and compare the results to our other ion source. PMID:23467295

Advanced Compton scattering light source R&D at LLNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Albert, F; Anderson, S G; Anderson, G

2010-02-16

We report the design and current status of a monoenergetic laser-based Compton scattering 0.5-2.5 MeV {gamma}-ray source. Previous nuclear resonance fluorescence results and future linac and laser developments for the source are presented. At MeV photon energies relevant for nuclear processes, Compton scattering light sources are attractive because of their relative compactness and improved brightness above 100 keV, compared to typical 4th generation synchrotrons. Recent progress in accelerator physics and laser technology have enabled the development of a new class of tunable Mono-Energetic Gamma-Ray (MEGa-Ray) light sources based on Compton scattering between a high-brightness, relativistic electron beam and a highmore » intensity laser pulse produced via chirped-pulse amplification (CPA). A new precision, tunable gamma-ray source driven by a compact, high-gradient X-band linac is currently under development and construction at LLNL. High-brightness, relativistic electron bunches produced by an X-band linac designed in collaboration with SLAC will interact with a Joule-class, 10 ps, diode-pumped CPA laser pulse to generate tunable {gamma}-rays in the 0.5-2.5 MeV photon energy range via Compton scattering. Based on the success of the previous Thomson-Radiated Extreme X-rays (T-REX) Compton scattering source at LLNL, the source will be used to excite nuclear resonance fluorescence lines in various isotopes; applications include homeland security, stockpile science and surveillance, nuclear fuel assay, and waste imaging and assay. After a brief presentation of successful nuclear resonance fluorescence (NRF) experiments done with T-REX, the new source design, key parameters, and current status are presented.« less

"Course Thesis" as End of the Laboratory Experimental Program

NASA Astrophysics Data System (ADS)

Dobrev, Alexandre A.

1996-09-01

The "course thesis" is introduced as end of the laboratory experimental program for the students in organic chemistry and consists of two- or three-step synthesis of an organic compound for which good procedures for synthesis are described in the literature. During the second semester, the student searches by himself the parameters and the known synthetical methods for the desired compound beginning with the general chemical encyclopedias and reaching to the original publications. The reaction scheme and the appropriate methods for the preparation of the target compound and its precursors are discussed with a member of the Department as a tutor. All results and information accumulated during the searching and the experimental work are summarized in a small thesis (5-10 pages) written in the style of scientific publication, with a title page, short introduction about the subject, review on the principal synthetic methods, experimental results and the literature sources. The student presents the essence of the thesis at a special Jury in the presence of his collegues and answers questions on the general aspects of the reaction used. The contribution of the thesis is that the student is placed in the real conditions of the research laboratory with self-dependent evaluation of the synthetical methods and all responsability of preparing the target compound.

Laboratory Tests of Multiplex Detection of PCR Amplicons Using the Luminex 100 Flow Analyzer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Venkateswaran, K.S.; Nasarabadi, S.; Langlois, R.G.

2000-05-05

Lawrence Livermore National Laboratory (LLNL) demonstrated the power of flow cytometry in detecting the biological agents simulants at JFT III. LLNL pioneered in the development of advanced nucleic acid analyzer (ANM) for portable real time identification. Recent advances in flow cytometry provide a means for multiplexed nucleic acid detection and immunoassay of pathogenic microorganisms. We are presently developing multiplexed immunoassays for the simultaneous detection of different simulants. Our goal is to build an integrated instrument for both nucleic acid analysis and immuno detection. In this study we evaluated the Luminex LX 100 for concurrent identification of more than one PCRmore » amplified product. ANAA has real-time Taqman fluorescent detection capability for rapid identification of field samples. However, its multiplexing ability is limited by the combination of available fluorescent labels. Hence integration of ANAA with flow cytometry can give the rapidity of ANAA amplification and the multiplex capability of flow cytometry. Multiplexed flow cytometric analysis is made possible using a set of fluorescent latex microsphere that are individually identified by their red and infrared fluorescence. A green fluorochrome is used as the assay signal. Methods were developed for the identification of specific nucleic acid sequences from Bacillus globigii (Bg), Bacillus thuringensis (Bt) and Erwinia herbicola (Eh). Detection sensitivity using different reporter fluorochromes was tested with the LX 100, and also different assay formats were evaluated for their suitability for rapid testing. A blind laboratory trial was carried out December 22-27, 1999 to evaluate bead assays for multiplex identification of Bg and Bt PCR products. This report summarizes the assay development, fluorochrome comparisons, and the results of the blind trial conducted at LLNL for the laboratory evaluation of the LX 100 flow analyzer.« less

Selected results from LLNL-Hughes RAR for West Coast Scotland Experiment 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lehman, S K; Johnston, B; Twogood, R

1993-01-05

The joint US -- UK 1991 West Coast Scotland Experiment (WCSEX) was held in two locations. From July 5 to 12, 1991, in Upper Loch Linnhe, and from July 18 to July 26, 1991, in the Sound of Sleat. The LLNL-Hughes team fielded a fully polarimetric X-band hill-side real aperture radar to collect internal wave wake data. We present here a sample data set of the best radar runs.

The National Ignition Facility: an experimental platform for studying behavior of matter under extreme conditions

NASA Astrophysics Data System (ADS)

Moses, Edward

2011-11-01

The National Ignition Facility (NIF), a 192-beam Nd-glass laser facility capable of producing 1.8 MJ and 500 TW of ultraviolet light, is now operational at Lawrence Livermore National Laboratory (LLNL). As the world's largest and most energetic laser system, NIF serves as the national center for the U.S. Department of Energy (DOE) and National Nuclear Security Administration to achieve thermonuclear burn in the laboratory and to explore the behavior of matter at extreme temperatures and energy densities. By concentrating the energy from all of its 192 extremely energetic laser beams into a mm3-sized target, NIF can reach the conditions required to initiate fusion reactions. NIF can also provide access to extreme scientific environments: temperatures about 100 million K, densities of 1,000 g/cm3, and pressures 100 billion times atmospheric pressure. These conditions have never been created before in a laboratory and exist naturally only in interiors of the planetary and stellar environments as well as in nuclear weapons. Since August 2009, the NIF team has been conducting experiments in support of the National Ignition Campaign (NIC)—a partnership among LLNL, Los Alamos National Laboratory, General Atomics, the University of Rochester, Sandia National Laboratories, as well as a number of universities and international collaborators. The results from these initial experiments show promise for the relatively near-term achievement of ignition. Capsule implosion experiments at energies up to 1.2 MJ have demonstrated laser energetics, radiation temperatures, and symmetry control that scale to ignition conditions. Of particular importance is the demonstration of peak hohlraum temperatures near 300 eV with overall backscatter less than 10%. Cryogenic target capability and additional diagnostics are being installed in preparation for layered target deuterium-tritium implosions to be conducted later in 2010. Important national security and basic science experiments have

Escambia Experimental Forest: A Living Laboratory for Long Term Longleaf Pine Research

Treesearch

Charles K. McMahon

2000-01-01

Experimental Forests have been used for many years by research organizations as "living laboratories" where long-term research studies can be conducted. For forestry and related natural resources research, "long term" can often mean decades of continuous study before meaningful results can be obtained. The Escambia Experimental Forest was...

A numerical cloud model for the support of laboratory experimentation

NASA Technical Reports Server (NTRS)

Hagen, D. E.

1979-01-01

A numerical cloud model is presented which can describe the evolution of a cloud starting from moist aerosol-laden air through the diffusional growth regime. The model is designed for the direct support of cloud chamber laboratory experimentation, i.e., experiment preparation, real-time control and data analysis. In the model the thermodynamics is uncoupled from the droplet growth processes. Analytic solutions for the cloud droplet growth equations are developed which can be applied in most laboratory situations. The model is applied to a variety of representative experiments.

An experimental test of an extended discretion approach for high school biology laboratory investigations

NASA Astrophysics Data System (ADS)

Leonard, William H.; Cavana, Gordon R.; Lowery, Lawrence F.

Discretion-the exercise of independent judgment-was observed to be lacking in most commercially available laboratory investigations for high school biology. An Extended Discretion (ED) laboratory approach was developed and tested experimentally against the BSCS Green Version laboratory program, using ten classes of 10th-grade biology in a suburban California high school. Five teachers were each assigned one experimental and one control group. The primary differences between the two approaches were that the BSCS was more prescriptive and directive than the ED approach and the ED approach increased discretionary demands upon the student over the school year. A treatment verification procedure showed statistically significant differences between the two approaches. The hypothesis under test was that when high school biology students are taught laboratory concepts under comparatively high discretionary demands, they would perform as well as or better than a similar group of students taught with BSCS Green Version investigations. A second hypothesis was that teachers would prefer to use the ED approach over the BSCS approach for their future classes. A t analysis between experimental and control groups for each teacher was employed. There were significant differences in favor of the ED group on laboratory report scores for three teachers and no differences for two teachers. There were significant differences in favor of the ED group on laboratory concepts quiz scores for three teachers, no differences for one teacher, and significant differences in favor of the BSCS group for only one teacher. A t analysis of teacher evaluation of the two approaches showed a significant teacher preference overall for the ED approach. Both experimental hypotheses were accepted. The ED approach was observed to be difficult for students at first, but it was found to be a workable and productive means of teaching laboratory concepts in biology which also required extensive use of individual

Lawrence Livermore National Laboratory Environmental Report 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosene, Crystal

The purposes of the Environmental Report 2016 are to record LLNL’s compliance with environmental standards and requirements, describe LLNL’s environmental protection and remediation programs, and present the results of environmental monitoring. Specifically, the report discusses LLNL’s EMS; describes significant accomplishments in pollution prevention; presents the results of air, water, vegetation, and foodstuff monitoring; reports radiological doses from LLNL operations; summarizes LLNL’s activities involving special status wildlife, plants, and habitats; and describes the progress LLNL has made in remediating groundwater contamination. Environmental monitoring at LLNL, including analysis of samples and data, is conducted according to documented standard operating procedures. Duplicate samplesmore » are collected and analytical results are reviewed and compared to internal acceptance standards. This report is prepared for DOE by LLNL’s Environmental Functional Area (EFA). Submittal of the report satisfies requirements under DOE Order 231.1B, “Environment, Safety and Health Reporting,” and DOE Order 458.1, “Radiation Protection of the Public and Environment.” The report is distributed in electronic form and is available to the public at https://saer.llnl.gov/, the website for the LLNL annual environmental report. Previous LLNL annual environmental reports beginning with 1994 are also on the website.« less

Edge Simulation Laboratory Progress and Plans

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cohen, R

The Edge Simulation Laboratory (ESL) is a project to develop a gyrokinetic code for MFE edge plasmas based on continuum (Eulerian) techniques. ESL is a base-program activity of OFES, with an allied algorithm research activity funded by the OASCR base math program. ESL OFES funds directly support about 0.8 FTE of career staff at LLNL, a postdoc and a small fraction of an FTE at GA, and a graduate student at UCSD. In addition the allied OASCR program funds about 1/2 FTE each in the computations directorates at LBNL and LLNL. OFES ESL funding for LLNL and UCSD began inmore » fall 2005, while funding for GA and the math team began about a year ago. ESL's continuum approach is a complement to the PIC-based methods of the CPES Project, and was selected (1) because of concerns about noise issues associated with PIC in the high-density-contrast environment of the edge pedestal, (2) to be able to exploit advanced numerical methods developed for fluid codes, and (3) to build upon the successes of core continuum gyrokinetic codes such as GYRO, GS2 and GENE. The ESL project presently has three components: TEMPEST, a full-f, full-geometry (single-null divertor, or arbitrary-shape closed flux surfaces) code in E, {mu} (energy, magnetic-moment) coordinates; EGK, a simple-geometry rapid-prototype code, presently of; and the math component, which is developing and implementing algorithms for a next-generation code. Progress would be accelerated if we could find funding for a fourth, computer science, component, which would develop software infrastructure, provide user support, and address needs for data handing and analysis. We summarize the status and plans for the three funded activities.« less

The Plymouth Laboratory and the institutionalization of experimental zoology in Britain in the 1920s.

PubMed

Erlingsson, Steindór J

2009-01-01

The Plymouth Laboratory of the Marine Biological Association of the United Kingdom (1884) was founded in 1888. In addition to conducting morphological and other biological research, the founders of the laboratory aimed at promoting research in experimental zoology which will be used in this paper as a synonym for e.g. experimental embryology, comparative physiology or general physiology. This dream was not fully realized until 1920. The Great War and its immediate aftermath had a positive impact on the development of the Plymouth Laboratory. The war greatly upset the operation of the Zoological Station in Naples and the ensuing crisis in its operations was closely related to the establishment of the physiological department in Plymouth in 1920. Two other key factors in the Plymouth story were the establishment of the Development Fund in 1909, which began contributing funds to the Plymouth Laboratory in 1912, and the patronage of the Cambridge zoologist George P. Bidder (1863-1954). This paper will focus on the combined influence of the Development Fund and Bidder on the development of the Plymouth Laboratory from around 1902 through the early 1920s, and the important role the laboratory played in promoting experimental zoology in Britain in the 1920s.

Ultra-trace analysis of 41Ca in urine by accelerator mass spectrometry: an inter-laboratory comparison

PubMed Central

Jackson, George S.; Hillegonds, Darren J.; Muzikar, Paul; Goehring, Brent

2013-01-01

A 41Ca interlaboratory comparison between Lawrence Livermore National Laboratory (LLNL) and the Purdue Rare Isotope Laboratory (PRIME Lab) has been completed. Analysis of the ratios assayed by accelerator mass spectrometry (AMS) shows that there is no statistically significant difference in the ratios. Further, Bayesian analysis shows that the uncertainties reported by both facilities are correct with the possibility of a slight under-estimation by one laboratory. Finally, the chemistry procedures used by the two facilities to produce CaF2 for the cesium sputter ion source are robust and don't yield any significant differences in the final result. PMID:24179312

General Science, Ninth Grade: Theme III and Theme IV. Student Laboratory Manual. Experimental.

ERIC Educational Resources Information Center

New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

This document is the student laboratory manual that was designed to accompany some of the experimental activities found in the teacher's guide to this general science course for ninth graders. It contains laboratory worksheets for lessons on such topics as: (1) soil; (2) hazardous waste; (3) wildlife refuges; (4) the water cycle; (5) water…

Final Report Bald and Golden Eagle Territory Surveys for the Lawrence Livermore National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fratanduono, M. L.

2014-11-25

Garcia and Associates (GANDA) was contracted by the Lawrence Livermore National Laboratory (LLNL) to conduct surveys for bald eagles (Haliaeetus leucocephalus) and golden eagles (Aquila chrysaetos) at Site 300 and in the surrounding area out to 10-miles. The survey effort was intended to document the boundaries of eagle territories by careful observation of eagle behavior from selected viewing locations throughout the study area.

Multilayer deposition and EUV reflectance characterization of 131 ? flight mirrors for AIA at LLNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soufli, R; Robinson, J C; Spiller, E

2006-02-22

Mo/Si multilayer coatings reflecting at 131 {angstrom} were deposited successfully on the AIA primary and secondary flight mirrors and on two coating witness Si wafers, on November 16, 2005, at LLNL. All coatings were characterized by means of EUV reflectance measurements at beamline 6.3.2 of the Advanced Light Source (ALS) synchrotron at LBNL, and were found to be well within specifications.

Collaborative Model for Remote Experimentation Laboratories Used by Non-Hierarchical Distributed Groups of Engineering Students

ERIC Educational Resources Information Center

Herrera, Oriel A.; Fuller, David A.

2011-01-01

Remote experimentation laboratories (REL) are systems based on real equipment that allow students to carry out a laboratory practice through the Internet on the computer. In engineering, there have been numerous initiatives to implement REL over recent years, given the fundamental role of laboratory activities. However, in the past efforts have…

Impact of the Revised 10 CFR 835 on the Neutron Dose Rates at LLNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Radev, R

2009-01-13

In June 2007, 10 CFR 835 [1] was revised to include new radiation weighting factors for neutrons, updated dosimetric models, and dose terms consistent with the newer ICRP recommendations. A significant aspect of the revised 10 CFR 835 is the adoption of the recommendations outlined in ICRP-60 [2]. The recommended new quantities demand a review of much of the basic data used in protection against exposure to sources of ionizing radiation. The International Commission on Radiation Units and Measurements has defined a number of quantities for use in personnel and area monitoring [3,4,5] including the ambient dose equivalent H*(d) tomore » be used for area monitoring and instrument calibrations. These quantities are used in ICRP-60 and ICRP-74. This report deals only with the changes in the ambient dose equivalent and ambient dose rate equivalent for neutrons as a result of the implementation of the revised 10 CFR 835. In the report, the terms neutron dose and neutron dose rate will be used for convenience for ambient neutron dose and ambient neutron dose rate unless otherwise stated. This report provides a qualitative and quantitative estimate of how much the neutron dose rates at LLNL will change with the implementation of the revised 10 CFR 835. Neutron spectra and dose rates from selected locations at the LLNL were measured with a high resolution spectroscopic neutron dose rate system (ROSPEC) as well as with a standard neutron rem meter (a.k.a., a remball). The spectra obtained at these locations compare well with the spectra from the Radiation Calibration Laboratory's (RCL) bare californium source that is currently used to calibrate neutron dose rate instruments. The measurements obtained from the high resolution neutron spectrometer and dose meter ROSPEC and the NRD dose meter compare within the range of {+-}25%. When the new radiation weighting factors are adopted with the implementation of the revised 10 CFR 835, the measured dose rates will increase by up

On the Integration of Remote Experimentation into Undergraduate Laboratories-Technical Implementation

ERIC Educational Resources Information Center

Esche, Sven K.

2006-01-01

This article presents how Stevens Institute of Technology (SIT) has adopted an Internet-based approach to implement its undergraduate student laboratories. The approach allowed student interaction with the experimental devices from remote locations at any time. Furthermore, it enabled instructors to include demonstrations of sophisticated…

The Bigfoot Drive; Experimental Results

NASA Astrophysics Data System (ADS)

Baker, Kevin; Thomas, Cliff; Khan, Shahab; Casey, Daniel; Spears, Brian; Nora, Ryan; Munro, Davis; Eder, David; Milovich, Jose; Berger, Dick; Strozzi, David; Goyon, Clement; Turnbull, David; Ma, Tammy; Izumi, Nobuhiko; Benedetti, Robin; Millot, Marius; Celliers, Peter; Yeamans, Charles; Hatarik, Robert; Landen, Nino; Hurricane, Omar; Callahan, Debbie

2016-10-01

The Bigfoot platform was developed on the National Ignition Facility to investigate low convergence, high adiabat, high rhoR hotspot implosions. This platform was designed to be less susceptible to wall motion, LPI and CBET and to be more robust against capsule hydrodynamic instabilities. To date experimental studies have been carried out at two hohlraum scales, a 5.75 and 5.4 mm diameter hohlraum. We will present experimental results from these tuning campaigns including the shape vs. cone fraction, surrogacy comparisons of self-emission from the capsules vs. radiography of the imploding capsule and doped vs. undoped capsules. Prepared by LLNL under Contract DE-AC52-07NA27344.

Final Report for the Arroyo Las Positas Maintenance Impact Study, Lawrence Livermore National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

van Hattem, M; Paterson, L

2006-01-12

In 2000, the Lawrence Livermore National Laboratory's (LLNL) Environmental Protection Department, in coordination with Plant Engineering (PE), began dredging sections of the Arroyo Las Positas (ALP) to alleviate concerns about flooding of sensitive facilities within the mainsite of Lawrence Livermore National Laboratory. In order to reduce potential impacts on the federally threatened California red-legged frog (Rana aurora draytonii), LLNL proposed to dredge sections of the ALP in a ''checkerboard pattern'', resulting in a mosaic of open water habitat and vegetated sections (Figure 1). The Arroyo Las Positas Management Plan (Plan) was coordinated with both state and federal agencies including themore » U.S. Fish and Wildlife Service (USFWS), California Department of Fish and Game (CDF&G), San Francisco Regional Water Quality Control Board (SFRWQCB), and the Army Corp of Engineers (ACOE). Water Discharge Requirements (WDRs) were issued for this project on December 30, 1999 (Order No. 99-086) by the SFRWQCB. Provision 19 of the WDRs outlined a five-year (2000 through 2004) Maintenance Impact Study (MIS) that LLNL began in coordination with dredging work that was conducted as part of the Arroyo Las Positas Management Plan. Provision 20 of these WDRs requires LLNL to submit a final report of the results of the Maintenance Impact Study for this project to the SFRWQCB. The purpose of this report is to present the results of the Maintenance Impact Study for Arroyo Las Positas and meet the requirements of Provision 20. A description of the annual monitoring included in this Maintenance Impact Study is included in the methods section of this report. Initially the Plan called for dredging the entire length of the Arroyo Las Positas (approximately 6,981 linear feet) over a 5-year period to minimize temporal impacts on the California red-legged frog. Dredging occurred in 2000 ({approx}1,300 ft.), 2001 ({approx}800 ft.), and 2002 ({approx}1,200 ft.), which constituted

Attenuation Drift in the Micro-Computed Tomography System at LLNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dooraghi, Alex A.; Brown, William; Seetho, Isaac

2016-01-12

The maximum allowable level of drift in the linear attenuation coefficients (μ) for a Lawrence Livermore National Laboratory (LLNL) micro-computed tomography (MCT) system was determined to be 0.1%. After ~100 scans were acquired during the period of November 2014 to March 2015, the drift in μ for a set of six reference materials reached or exceeded 0.1%. Two strategies have been identified to account for or correct the drift. First, normalizing the 160 kV and 100 kV μ data by the μ of water at the corresponding energy, in contrast to conducting normalization at the 160 kV energy only, significantlymore » compensates for measurement drift. Even after the modified normalization, μ of polytetrafluoroethylene (PTFE) increases linearly with scan number at an average rate of 0.00147% per scan. This is consistent with PTFE radiation damage documented in the literature. The second strategy suggested is the replacement of the PTFE reference with fluorinated ethylene propylene (FEP), which has the same effective atomic number (Ze) and electron density (ρe) as PTFE, but is 10 times more radiation resistant. This is important as effective atomic number and electron density are key parameters in analysis. The presence of a material with properties such as PTFE, when taken together with the remaining references, allows for a broad range of the (Ze, ρe) feature space to be used in analysis. While FEP is documented as 10 times more radiation resistant, testing will be necessary to assess how often, if necessary, FEP will need to be replaced. As radiation damage to references has been observed, it will be necessary to monitor all reference materials for radiation damage to ensure consistent x-ray characteristics of the references.« less

Transient plasma estimation: a noise cancelling/identification approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Candy, J.V.; Casper, T.; Kane, R.

1985-03-01

The application of a noise cancelling technique to extract energy storage information from sensors occurring during fusion reactor experiments on the Tandem Mirror Experiment-Upgrade (TMX-U) at the Lawrence Livermore National Laboratory (LLNL) is examined. We show how this technique can be used to decrease the uncertainty in the corresponding sensor measurements used for diagnostics in both real-time and post-experimental environments. We analyze the performance of algorithm on the sensor data and discuss the various tradeoffs. The algorithm suggested is designed using SIG, an interactive signal processing package developed at LLNL.

Recent results and future plans for a 45 actuator adaptive x-ray optics experiment at the advanced light source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brejnholt, Nicolai F., E-mail: brejnholt1@llnl.gov; Poyneer, Lisa A.; Hill, Randal M.

2016-07-27

We report on the current status of the Adaptive X-ray Optics project run by Lawrence Livermore National Laboratory (LLNL). LLNL is collaborating with the Advanced Light Source (ALS) to demonstrate a near real-time adaptive X-ray optic. To this end, a custom-built 45 cm long deformable mirror has been installed at ALS beamline 5.3.1 (end station 2) for a two-year period that started in September 2014. We will outline general aspects of the instrument, present results from a recent experimental campaign and touch on future plans for the project.

A Funding Simulation for Use in an Advanced Experimental Laboratory Class.

ERIC Educational Resources Information Center

Falkenberg, Virginia P.

1981-01-01

Describes a funding simulation for use with college students in an advanced experimental psychology laboratory. Students write an original research paper and submit it to the professor--the "funding agency"--as a grant proposal. Projects are funded with grade points with which the student director purchases help from unfunded classmates. (RM)

Lawrence Livermore National Laboratory Environmental Report 2014

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, H. E.; Bertoldo, N. A.; Blake, R. G.

The purposes of the Lawrence Livermore National Laboratory Environmental Report 2014 are to record Lawrence Livermore National Laboratory’s (LLNL’s) compliance with environmental standards and requirements, describe LLNL’s environmental protection and remediation programs, and present the results of environmental monitoring at the two LLNL sites—the Livermore Site and Site 300. The report is prepared for the U.S. Department of Energy (DOE) by LLNL’s Environmental Functional Area. Submittal of the report satisfies requirements under DOE Order 231.1B, “Environment, Safety and Health Reporting,” and DOE Order 458.1, “Radiation Protection of the Public and Environment.”

Lawrence Livermore National Laboratory Environmental Report 2015

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosene, C. A.; Jones, H. E.

The purposes of the Lawrence Livermore National Laboratory Environmental Report 2015 are to record Lawrence Livermore National Laboratory’s (LLNL’s) compliance with environmental standards and requirements, describe LLNL’s environmental protection and remediation programs, and present the results of environmental monitoring at the two LLNL sites—the Livermore Site and Site 300. The report is prepared for the U.S. Department of Energy (DOE) by LLNL’s Environmental Functional Area. Submittal of the report satisfies requirements under DOE Order 231.1B, “Environment, Safety and Health Reporting,” and DOE Order 458.1, “Radiation Protection of the Public and Environment.”

Open-ended versus guided laboratory activities:Impact on students' beliefs about experimental physics

NASA Astrophysics Data System (ADS)

Wilcox, Bethany R.; Lewandowski, H. J.

2016-12-01

Improving students' understanding of the nature of experimental physics is often an explicit or implicit goal of undergraduate laboratory physics courses. However, lab activities in traditional lab courses are typically characterized by highly structured, guided labs that often do not require or encourage students to engage authentically in the process of experimental physics. Alternatively, open-ended laboratory activities can provide a more authentic learning environment by, for example, allowing students to exercise greater autonomy in what and how physical phenomena are investigated. Engaging in authentic practices may be a critical part of improving students' beliefs around the nature of experimental physics. Here, we investigate the impact of open-ended activities in undergraduate lab courses on students' epistemologies and expectations about the nature of experimental physics, as well as their confidence and affect, as measured by the Colorado Learning Attitudes about Science Survey for Experimental Physics (E-CLASS). Using a national data set of student responses to the E-CLASS, we find that the inclusion of some open-ended lab activities in a lab course correlates with more expertlike postinstruction responses relative to courses that include only traditional guided lab activities. This finding holds when examining postinstruction E-CLASS scores while controlling for the variance associated with preinstruction scores, course level, student major, and student gender.

The U.S. Geological Survey Paleomagnetics Laboratory at Fort Valley Experimental Forest-1970-1991

Treesearch

Shirley Elston; Carolyn Shoemaker

2008-01-01

The United States Geological Survey (USGS) Paleomagnetics Laboratory was established in 1970, when Dr. Donald P. Elston of USGS negotiated with officials of the U.S. Forest Service in Flagstaff for the use of several buildings at the Fort Valley Experimental Forest (FVEF). The Fort Valley location was ideal for use as a laboratory, because its distance from Flagstaff...

Characterizing the Experimental Procedure in Science Laboratories: A preliminary step towards students experimental design

NASA Astrophysics Data System (ADS)

Girault, Isabelle; d'Ham, Cedric; Ney, Muriel; Sanchez, Eric; Wajeman, Claire

2012-04-01

Many studies have stressed students' lack of understanding of experiments in laboratories. Some researchers suggest that if students design all or parts of entire experiment, as part of an inquiry-based approach, it would overcome certain difficulties. It requires that a procedure be written for experimental design. The aim of this paper is to describe the characteristics of a procedure in science laboratories, in an educational context. As a starting point, this paper proposes a model in the form of a hierarchical task diagram that gives the general structure of any procedure. This model allows both the analysis of existing procedures and the design of a new inquiry-based approach. The obtained characteristics are further organized into criteria that can help both teachers and students assess a procedure during and after its writing. These results are obtained through two different sets of data. First, the characteristics of procedures are established by analysing laboratory manuals. This allows the organization and type of information in procedures to be defined. This analysis reveals that students are seldom asked to write a full procedure, but sometimes have to specify tasks within a procedure. Secondly, iterative interviews are undertaken with teachers. This leads to the list of criteria to evaluate the procedure.

LLNL compiled first pages ordered by ascending B&R code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Campbell, G; Kumar, M; Tobin, J

We aim to develop a fundamental understanding of materials dynamics (from {micro}s to ns) in systems where the required combination of spatial and temporal resolution can only be reached by the dynamic transmission electron microscope (DTEM). In this regime, the DTEM is capable of studying complex transient phenomena with several orders of magnitude time resolution advantage over any existing in-situ TEM. Using the unique in situ capabilities and the nanosecond time resolution of the DTEM, we seek to study complex transient phenomena associated with rapid processes in materials, such as active sites on nanoscale catalysts and the atomic level mechanismsmore » and microstructural features for nucleation and growth associated with phase transformations in materials, specifically in martensite formation and crystallization reactions from the amorphous phase. We also will study the transient phase evolution in rapid solid-state reactions, such as those occurring in reactive multilayer foils (RMLF). Program Impact: The LLNL DTEM possesses unique capabilities for capturing time resolved images and diffraction patterns of rapidly evolving materials microstructure under strongly driven conditions. No other instrument in the world can capture images with <10 nm spatial resolution of interesting irreversible materials processes such as phase transformations, plasticity, or morphology changes with 15 ns time resolution. The development of this innovative capability requires the continuing collaboration of laser scientists, electron microscopists, and materials scientists experienced in time resolved observations of materials that exist with particularly relevant backgrounds at LLNL. The research team has made observations of materials processes that are possible by no other method, such as the rapid crystallization of thin film NiTi that identified a change in mechanism at high heating rates as compared to isothermal anneals through changes in nucleation and growth rates of

Simulations of the Richtmyer-Meshkov Instability with experimentally measured volumetric initial conditions

NASA Astrophysics Data System (ADS)

Ferguson, Kevin; Sewell, Everest; Krivets, Vitaliy; Greenough, Jeffrey; Jacobs, Jeffrey

2016-11-01

Initial conditions for the Richtmyer-Meshkov instability (RMI) are measured in three dimensions in the University of Arizona Vertical Shock Tube using a moving magnet galvanometer system. The resulting volumetric data is used as initial conditions for the simulation of the RMI using ARES at Lawrence-Livermore National Laboratory (LLNL). The heavy gas is sulfur hexafluoride (SF6), and the light gas is air. The perturbations are generated by harmonically oscillating the gasses vertically using two loudspeakers mounted to the shock tube which cause Faraday resonance, producing a random short wavelength perturbation on the interface. Planar Mie scattering is used to illuminate the flow field through the addition of propylene glycol particles seeded in the heavy gas. An M=1.2 shock impulsively accelerates the interface, initiating instability growth. Images of the initial condition and instability growth are captured at a rate of 6 kHz using high speed cameras. Comparisons between experimental and simulation results, mixing diagnostics, and mixing zone growth are presented.

Detailed characterization of the LLNL imaging proton spectrometer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rasmus, A. M., E-mail: rasmus@lanl.gov, E-mail: arasmus@umich.edu; University of Michigan, Ann Arbor, Michigan 48109; Hazi, A. U.

2016-11-15

Ultra-intense short pulse lasers incident on solid targets (e.g., thin Au foils) produce well collimated, broad-spectrum proton beams. These proton beams can be used to characterize magnetic fields, electric fields, and density gradients in high energy-density systems. The LLNL-Imaging Proton Spectrometer (L-IPS) was designed and built [H. Chen et al., Rev. Sci. Instrum. 81, 10D314 (2010)] for use with such laser produced proton beams. The L-IPS has an energy range of 50 keV-40 MeV with a resolving power (E/dE) of about 275 at 1 MeV and 21 at 20 MeV, as well as a single spatial imaging axis. In ordermore » to better characterize the dispersion and imaging capability of this diagnostic, a 3D finite element analysis solver is used to calculate the magnetic field of the L-IPS. Particle trajectories are then obtained via numerical integration to determine the dispersion relation of the L-IPS in both energy and angular space.« less

Biological and Chemical Security

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fitch, P J

2002-12-19

The LLNL Chemical & Biological National Security Program (CBNP) provides science, technology and integrated systems for chemical and biological security. Our approach is to develop and field advanced strategies that dramatically improve the nation's capabilities to prevent, prepare for, detect, and respond to terrorist use of chemical or biological weapons. Recent events show the importance of civilian defense against terrorism. The 1995 nerve gas attack in Tokyo's subway served to catalyze and focus the early LLNL program on civilian counter terrorism. In the same year, LLNL began CBNP using Laboratory-Directed R&D investments and a focus on biodetection. The Nunn-Lugar-Domenici Defensemore » Against Weapons of Mass Destruction Act, passed in 1996, initiated a number of U.S. nonproliferation and counter-terrorism programs including the DOE (now NNSA) Chemical and Biological Nonproliferation Program (also known as CBNP). In 2002, the Department of Homeland Security was formed. The NNSA CBNP and many of the LLNL CBNP activities are being transferred as the new Department becomes operational. LLNL has a long history in national security including nonproliferation of weapons of mass destruction. In biology, LLNL had a key role in starting and implementing the Human Genome Project and, more recently, the Microbial Genome Program. LLNL has over 1,000 scientists and engineers with relevant expertise in biology, chemistry, decontamination, instrumentation, microtechnologies, atmospheric modeling, and field experimentation. Over 150 LLNL scientists and engineers work full time on chemical and biological national security projects.« less

Feasibility of Wide-Area Decontamination of Bacillus anthracis Spores Using a Germination-Lysis Approach

DTIC Science & Technology

2011-11-16

Security, LLC 2011 CBD S& T Conference November 16, 2011 LLNL-PRES-508394 Lawrence Livermore National Laboratory LLNL-PRES-  Background...PRES-  Gruinard Island 5% formaldehyde  Sverdlosk Release UNKNOWN: but washing, chloramines , soil disposal believed to have been used...508394 Lawrence Livermore National Laboratory LLNL-PRES- 4 Disinfectant >6 Log Reduction on Materials (EPA, 2010a,b; Wood et al., 2011

Cold Climate Foundation Retrofit Experimental Hygrothermal Performance. Cloquet Residential Research Facility Laboratory Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goldberg, Louise F.; Harmon, Anna C.

2015-04-09

This project was funded jointly by the National Renewable Energy Laboratory (NREL) and Oak Ridge National Laboratory (ORNL). ORNL focused on developing a full basement wall system experimental database to enable others to validate hygrothermal simulation codes. NREL focused on testing the moisture durability of practical basement wall interior insulation retrofit solutions for cold climates. The project has produced a physically credible and reliable long-term hygrothermal performance database for retrofit foundation wall insulation systems in zone 6 and 7 climates that are fully compliant with the performance criteria in the 2009 Minnesota Energy Code. These data currently span the periodmore » from November 10, 2012 through May 31, 2014 and are anticipated to be extended through November 2014. The experimental data were configured into a standard format that can be published online and that is compatible with standard commercially available spreadsheet and database software.« less

Review of Excess Weapons Plutonium Disposition LLNL Contract Work in Russia-(English)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jardine, L; Borisov, G B

This third meeting of the recently completed and ongoing Russian plutonium immobilization contract work was held at the State Education Center (SEC) in St. Petersburg on January 14-18, 2002. The meeting agenda is reprinted here as Appendix A and the attendance list as Appendix B. The meeting had 58 Russian participants from 21 Russian organizations, including the industrial sites (Mayak, Krasonayarsk-26, Tomsk), scientific institutes (VNIINM, KRI, VNIPIPT, RIAR), design organizations (VNIPIET and GSPI), universities (Nyzhny Novgorod, Urals Technical), Russian Academy of Sciences (Institute of Physical Chemistry or IPhCh, Institute of Ore-Deposit Geology, Petrography, Mineralogy, and Geochemistry or IGEM), Radon-Moscow, S&TCmore » Podol'osk, Kharkov-Ukraine, GAN-SEC-NRS and SNIIChM, the RF Ministry of Atomic Energy (Minatom) and Gosatomnadzor (GAN). This volume, published by LLNL, documents this third annual meeting. Forty-nine technical papers were presented by the Russian participants, and nearly all of these have been collected in this Proceedings. The two objectives for the meeting were to: (1) Bring together the Russian organizations, experts, and managers performing this contract work into one place for four days to review and discuss their work amongst each other. (2) Publish a meeting summary and proceedings of all the excellent Russian plutonium immobilization and other plutonium disposition contract work in one document so that the wide extent of the Russian immobilization activities are documented, referencable and available for others to use, as were the Proceedings of the two previous meetings. Attendees gave talks describing their LLNL contract work and submitted written papers documenting their contract work (in English and Russian), in both hard copy and on computer disks. Simultaneous translation into Russian and English was used for presentations made at the State Region Educational Center (SEC).« less

[Some notes on the history of the experimental surgery laboratory. Reflections on its relevance in education and surgical research].

PubMed

de la Garza-Rodea, Anabel Sofía; Padilla-Sánchez, Luis; de la Garza-Aguilar, Javier; Neri-Vela, Rolando

2007-01-01

The progress of medicine has largely been due to research, and for surgery, in particular, the experimental surgical laboratory has been considered fundamental to the surgeon's education. In this study, a general view of experimental surgery is given in animal models based on bioethical norms as well as to design, create and apply different surgical procedures before performing in humans. Experimental surgery also facilitates surgical teaching and promotes the surgeon's scientific reasoning. Methods. This is a retrospective and descriptive study. Data were collected from direct and indirect sources of available publications on the historical, bioethical and educational aspects of medicine, focusing on surgery. The important facts corresponding to the field of experimental surgery and applicable in Mexico were selected. Concepts of experimental surgical models and of the experimental surgery laboratory were described. Bioethical considerations are emphasized for care of experimental animals. Finally, this work focuses on the importance of surgical experimentation in current and future development of the surgical researcher. Conclusions. Experimentation with animal models in a surgical laboratory is essential for surgical teaching and promotes development of the scientific thought in the surgeon. It is necessary for surgical research and is fundamental for making progress in surgery, treatment and medicine as science.

A Monte Carlo Simulation of the in vivo measurement of lung activity in the Lawrence Livermore National Laboratory torso phantom.

PubMed

Acha, Robert; Brey, Richard; Capello, Kevin

2013-02-01

A torso phantom was developed by the Lawrence Livermore National Laboratory (LLNL) that serves as a standard for intercomparison and intercalibration of detector systems used to measure low-energy photons from radionuclides, such as americium deposited in the lungs. DICOM images of the second-generation Human Monitoring Laboratory-Lawrence Livermore National Laboratory (HML-LLNL) torso phantom were segmented and converted into three-dimensional (3D) voxel phantoms to simulate the response of high purity germanium (HPGe) detector systems, as found in the HML new lung counter using a Monte Carlo technique. The photon energies of interest in this study were 17.5, 26.4, 45.4, 59.5, 122, 244, and 344 keV. The detection efficiencies at these photon energies were predicted for different chest wall thicknesses (1.49 to 6.35 cm) and compared to measured values obtained with lungs containing (241)Am (34.8 kBq) and (152)Eu (10.4 kBq). It was observed that no statistically significant differences exist at the 95% confidence level between the mean values of simulated and measured detection efficiencies. Comparisons between the simulated and measured detection efficiencies reveal a variation of 20% at 17.5 keV and 1% at 59.5 keV. It was found that small changes in the formulation of the tissue substitute material caused no significant change in the outcome of Monte Carlo simulations.

Net Weight Issue LLNL DOE-STD-3013 Containers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilk, P

2008-01-16

The following position paper will describe DOE-STD-3013 container sets No.L000072 and No.L000076, and how they are compliant with DOE-STD-3013-2004. All masses of accountable nuclear materials are measured on LLNL certified balances maintained under an MC&A Program approved by DOE/NNSA LSO. All accountability balances are recalibrated annually and checked to be within calibration on each day that the balance is used for accountability purposes. A statistical analysis of the historical calibration checks from the last seven years indicates that the full-range Limit of Error (LoE, 95% confidence level) for the balance used to measure the mass of the contents of themore » above indicated 3013 containers is 0.185 g. If this error envelope, at the 95% confidence level, were to be used to generate an upper-limit to the measured weight of the containers No.L000072 and No.L000076, the error-envelope would extend beyond the 5.0 kg 3013-standard limit on the package contents by less than 0.3 g. However, this is still well within the intended safety bounds of DOE-STD-3013-2004.« less

33 CFR 334.150 - Severn River at Annapolis, Md.; experimental test area, U.S. Navy Marine Engineering Laboratory.

Code of Federal Regulations, 2012 CFR

2012-07-01

....; experimental test area, U.S. Navy Marine Engineering Laboratory. 334.150 Section 334.150 Navigation and... Marine Engineering Laboratory. (a) The restricted area. The waters of Severn River shoreward of a line beginning at the southeasternmost corner of the U.S. Navy Marine Engineering Laboratory sea wall and running...

33 CFR 334.150 - Severn River at Annapolis, Md.; experimental test area, U.S. Navy Marine Engineering Laboratory.

Code of Federal Regulations, 2011 CFR

2011-07-01

....; experimental test area, U.S. Navy Marine Engineering Laboratory. 334.150 Section 334.150 Navigation and... Marine Engineering Laboratory. (a) The restricted area. The waters of Severn River shoreward of a line beginning at the southeasternmost corner of the U.S. Navy Marine Engineering Laboratory sea wall and running...

33 CFR 334.150 - Severn River at Annapolis, Md.; experimental test area, U.S. Navy Marine Engineering Laboratory.

Code of Federal Regulations, 2014 CFR

2014-07-01

....; experimental test area, U.S. Navy Marine Engineering Laboratory. 334.150 Section 334.150 Navigation and... Marine Engineering Laboratory. (a) The restricted area. The waters of Severn River shoreward of a line beginning at the southeasternmost corner of the U.S. Navy Marine Engineering Laboratory sea wall and running...

33 CFR 334.150 - Severn River at Annapolis, Md.; experimental test area, U.S. Navy Marine Engineering Laboratory.

Code of Federal Regulations, 2013 CFR

2013-07-01

....; experimental test area, U.S. Navy Marine Engineering Laboratory. 334.150 Section 334.150 Navigation and... Marine Engineering Laboratory. (a) The restricted area. The waters of Severn River shoreward of a line beginning at the southeasternmost corner of the U.S. Navy Marine Engineering Laboratory sea wall and running...

33 CFR 334.150 - Severn River at Annapolis, Md.; experimental test area, U.S. Navy Marine Engineering Laboratory.

Code of Federal Regulations, 2010 CFR

2010-07-01

....; experimental test area, U.S. Navy Marine Engineering Laboratory. 334.150 Section 334.150 Navigation and... Marine Engineering Laboratory. (a) The restricted area. The waters of Severn River shoreward of a line beginning at the southeasternmost corner of the U.S. Navy Marine Engineering Laboratory sea wall and running...

Choice of experimental venue matters in ecotoxicology studies: Comparison of a laboratory-based and an outdoor mesocosm experiment.

PubMed

Mikó, Zsanett; Ujszegi, János; Gál, Zoltán; Imrei, Zoltán; Hettyey, Attila

2015-10-01

The heavy application of pesticides and its potential effects on natural communities has attracted increasing attention to inadvertent impacts of these chemicals. Toxicologists conventionally use laboratory-based tests to assess lethal concentrations of pesticides. However, these tests often do not take into account indirect, interactive and long-term effects, and tend to ignore different rates of disintegration in the laboratory and under natural conditions. Our aim was to investigate the importance of the experimental venue for ecotoxicology tests. We reared tadpoles of the agile frog (Rana dalmatina) in the laboratory and in outdoor mesocosms and exposed them to three initial concentrations of a glyphosate-based herbicide (0, 2 and 6.5 mg a.e./L glyphosate), and to the presence or absence of caged predators (dragonfly larvae). The type of experimental venue had a large effect on the outcome: The herbicide was less lethal to tadpoles reared in outdoor mesocosms than in the laboratory. Further, while the herbicide had a negative effect on development time and on body mass in the laboratory, tadpoles exposed to the herbicide in mesocosms were larger at metamorphosis and developed faster in comparison to those reared in the absence of the herbicide. The effect of the herbicide on morphological traits of tadpoles also differed between the two venues. Finally, in the presence of the herbicide, tadpoles tended to be more active and to stay closer to the bottom of laboratory containers, while tadpole behaviour shifted in the opposite direction in outdoor mesocosms. Our results demonstrate major discrepancies between results of a classic laboratory-based ecotoxicity test and outcomes of an experiment performed in outdoor mesocosms. Consequently, the use of standard laboratory tests may have to be reconsidered and their benefits carefully weighed against the difficulties of performing experiments under more natural conditions. Tests validating experimentally estimated

Lawrence Livermore National Laboratory Site Seismic Safety Program: Summary of Findings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Savy, J B; Foxall, W

The Lawrence Livermore National Laboratory (LLNL) Site Seismic Safety Program was conceived in 1979 during the preparation of the site Draft Environmental Impact Statement. The impetus for the program came from the development of new methodologies and geologic data that affect assessments of geologic hazards at the LLNL site; it was designed to develop a new assessment of the seismic hazard to the LLNL site and LLNL employees. Secondarily, the program was also intended to provide the technical information needed to make ongoing decisions about design criteria for future construction at LLNL and about the adequacy of existing facilities. Thismore » assessment was intended to be of the highest technical quality and to make use of the most recent and accepted hazard assessment methodologies. The basic purposes and objectives of the current revision are similar to those of the previous studies. Although all the data and experience assembled in the previous studies were utilized to their fullest, the large quantity of new information and new methodologies led to the formation of a new team that includes LLNL staff and outside consultants from academia and private consulting firms. A peer-review panel composed of individuals from academia (A. Cornell, Stanford University), the Department of Energy (DOE; Jeff Kimball), and consulting (Kevin Coppersmith), provided review and guidance. This panel was involved from the beginning of the project in a ''participatory'' type of review. The Senior Seismic Hazard Analysis Committee (SSHAC, a committee sponsored by the U.S. Nuclear Regulatory Commission, DOE, and the Electric Power Research Institute) strongly recommends the use of participatory reviews, in which the reviewers follow the progress of a project from the beginning, rather than waiting until the end to provide comments (Budnitz et al., 1997). Following the requirements for probabilistic seismic hazard analysis (PSHA) stipulated in the DOE standard DOE-STD-1023-95, a

Open-Ended versus Guided Laboratory Activities: Impact on Students' Beliefs about Experimental Physics

ERIC Educational Resources Information Center

Wilcox, Bethany R.; Lewandowski, H. J.

2016-01-01

Improving students' understanding of the nature of experimental physics is often an explicit or implicit goal of undergraduate laboratory physics courses. However, lab activities in traditional lab courses are typically characterized by highly structured, guided labs that often do not require or encourage students to engage authentically in the…

July 1999 working group meeting on heavy vehicle aerodynamic drag: presentations and summary of comments and conclusions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brady, M; Browand, F; Flowers, D

A Working Group Meeting on Heavy Vehicle Aerodynamic Drag was held at University of Southern California, Los Angeles, California on July 30, 1999. The purpose of the meeting was to present technical details on the experimental and computational plans and approaches and provide an update on progress in obtaining experimental results, model developments, and simulations. The focus of the meeting was a review of University of Southern California's (USC) experimental plans and results and the computational results from Lawrence Livermore National Laboratory (LLNL) and Sandia National Laboratories (SNL) for the integrated tractor-trailer benchmark geometry called the Sandia Model. Much ofmore » the meeting discussion involved the NASA Ames 7 ft x 10 ft wind tunnel tests and the need for documentation of the results. The present and projected budget and funding situation was also discussed. Presentations were given by representatives from the Department of Energy (DOE) Office of Transportation Technology Office of Heavy Vehicle Technology (OHVT), LLNL, SNL, USC, and California Institute of Technology (Caltech). This report contains the technical presentations (viewgraphs) delivered at the Meeting, briefly summarizes the comments and conclusions, and outlines the future action items.« less

The U.S. Geological Survey Paleomagnetics Laboratory at Fort Valley Experimental Forest-1970-1991 (P-53)

Treesearch

Shirley Elston; Carolyn Shoemaker

2008-01-01

The United States Geological Survey (USGS) Paleomagnetics Laboratory was established in 1970, when Dr. Donald P. Elston of USGS negotiated with officials of the U.S. Forest Service in Flagstaff for the use of several buildings at the Fort Valley Experimental Forest (FVEF). The Fort Valley location was ideal for use as a laboratory, because its distance from Flagstaff...

LLNL's Big Science Capabilities Help Spur Over $796 Billion in U.S. Economic Activity Sequencing the Human Genome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stewart, Jeffrey S.

LLNL’s successful history of taking on big science projects spans beyond national security and has helped create billions of dollars per year in new economic activity. One example is LLNL’s role in helping sequence the human genome. Over $796 billion in new economic activity in over half a dozen fields has been documented since LLNL successfully completed this Grand Challenge.

Predictive Model and Methodology for Heat Treatment Distortion Final Report CRADA No. TC-298-92

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nikkel, D. J.; McCabe, J.

This project was a multi-lab, multi-partner CRADA involving LLNL, Los Alamos National Laboratory, Sandia National Laboratories, Oak Ridge National Laboratory, Martin Marietta Energy Systems and the industrial partner, The National Center of Manufacturing Sciences (NCMS). A number of member companies of NCMS participated including General Motors Corporation, Ford Motor Company, The Torrington Company, Gear Research, the Illinois Institute of Technology Research Institute, and Deformation Control Technology •. LLNL was the lead laboratory for metrology technology used for validation of the computational tool/methodology. LLNL was also the lead laboratory for the development of the software user interface , for the computationalmore » tool. This report focuses on the participation of LLNL and NCMS. The purpose of the project was to develop a computational tool/methodology that engineers would use to predict the effects of heat treatment on the _size and shape of industrial parts made of quench hardenable alloys. Initially, the target application of the tool was gears for automotive power trains.« less

The Computerized Laboratory Notebook concept for genetic toxicology experimentation and testing.

PubMed

Strauss, G H; Stanford, W L; Berkowitz, S J

1989-03-01

We describe a microcomputer system utilizing the Computerized Laboratory Notebook (CLN) concept developed in our laboratory for the purpose of automating the Battery of Leukocyte Tests (BLT). The BLT was designed to evaluate blood specimens for toxic, immunotoxic, and genotoxic effects after in vivo exposure to putative mutagens. A system was developed with the advantages of low cost, limited spatial requirements, ease of use for personnel inexperienced with computers, and applicability to specific testing yet flexibility for experimentation. This system eliminates cumbersome record keeping and repetitive analysis inherent in genetic toxicology bioassays. Statistical analysis of the vast quantity of data produced by the BLT would not be feasible without a central database. Our central database is maintained by an integrated package which we have adapted to develop the CLN. The clonal assay of lymphocyte mutagenesis (CALM) section of the CLN is demonstrated. PC-Slaves expand the microcomputer to multiple workstations so that our computerized notebook can be used next to a hood while other work is done in an office and instrument room simultaneously. Communication with peripheral instruments is an indispensable part of many laboratory operations, and we present a representative program, written to acquire and analyze CALM data, for communicating with both a liquid scintillation counter and an ELISA plate reader. In conclusion we discuss how our computer system could easily be adapted to the needs of other laboratories.

Wide Area Recovery and Resiliency Program (WARRP) Knowledge Enhancement Events: CBR Workshop After Action Report

DTIC Science & Technology

2012-01-01

Laboratories Walker Ray Walker Engineering Solutions, LLC Williams Patricia Denver Office of Emergency Management Wood- Zika Annmarie Lawrence Livermore...llnl.gov AnnMarie Wood- Zika woodzika1@llnl.gov Pacific Northwest National Laboratory Ann Lesperance ann.lesperance@pnnl.gov Jessica Sandusky

Simulation and Experimentation in an Astronomy Laboratory, Part II

NASA Astrophysics Data System (ADS)

Maloney, F. P.; Maurone, P. A.; Hones, M.

1995-12-01

The availability of low-cost, high-performance computing hardware and software has transformed the manner by which astronomical concepts can be re-discovered and explored in a laboratory that accompanies an astronomy course for non-scientist students. We report on a strategy for allowing each student to understand fundamental scientific principles by interactively confronting astronomical and physical phenomena, through direct observation and by computer simulation. Direct observation of physical phenomena, such as Hooke's Law, begins by using a computer and hardware interface as a data-collection and presentation tool. In this way, the student is encouraged to explore the physical conditions of the experiment and re-discover the fundamentals involved. The hardware frees the student from the tedium of manual data collection and presentation, and permits experimental design which utilizes data that would otherwise be too fleeting, too imprecise, or too voluminous. Computer simulation of astronomical phenomena allows the student to travel in time and space, freed from the vagaries of weather, to re-discover such phenomena as the daily and yearly cycles, the reason for the seasons, the saros, and Kepler's Laws. By integrating the knowledge gained by experimentation and simulation, the student can understand both the scientific concepts and the methods by which they are discovered and explored. Further, students are encouraged to place these discoveries in an historical context, by discovering, for example, the night sky as seen by the survivors of the sinking Titanic, or Halley's comet as depicted on the Bayeux tapestry. We report on the continuing development of these laboratory experiments. Futher details and the text for the experiments are available at the following site: http://astro4.ast.vill.edu/ This work is supported by a grant from The Pew Charitable Trusts.

Michael M. May: Working toward solutions

DOE Office of Scientific and Technical Information (OSTI.GOV)

May, M.M.

1993-07-01

As part of LLNL's 40th anniversary celebration held during 1992, the six former Directors were asked to participate in a lecture series. Each of these men contributed in important ways toward making the Lawrence Livermore National Laboratory (LLNL) what it has become today. Each was asked to comment on some of the Laboratory's accomplishments, his career here, his view of the changing world, and where he sees the Laboratory going in the future. Michael M. May, LLNL's fifth Director and now a Director Emeritus, comments on a broad range of issues including arms control, nonproliferation, cooperative security, and the futuremore » role of the Laboratory.« less

Experimental, Theoretical and Computational Studies of Plasma-Based Concepts for Future High Energy Accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Joshi, Chan; Mori, W.

2013-10-21

This is the final report on the DOE grant number DE-FG02-92ER40727 titled, “Experimental, Theoretical and Computational Studies of Plasma-Based Concepts for Future High Energy Accelerators.” During this grant period the UCLA program on Advanced Plasma Based Accelerators, headed by Professor C. Joshi has made many key scientific advances and trained a generation of students, many of whom have stayed in this research field and even started research programs of their own. In this final report however, we will focus on the last three years of the grant and report on the scientific progress made in each of the four tasksmore » listed under this grant. Four tasks are focused on: Plasma Wakefield Accelerator Research at FACET, SLAC National Accelerator Laboratory, In House Research at UCLA’s Neptune and 20 TW Laser Laboratories, Laser-Wakefield Acceleration (LWFA) in Self Guided Regime: Experiments at the Callisto Laser at LLNL, and Theory and Simulations. Major scientific results have been obtained in each of the four tasks described in this report. These have led to publications in the prestigious scientific journals, graduation and continued training of high quality Ph.D. level students and have kept the U.S. at the forefront of plasma-based accelerators research field.« less

FY17 LLNL Omega Experimental Programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heeter, R. F.; Albert, F.; Ali, S. J.

The Capseed campaign goal is to measure shock front velocity non-uniformities in Inertial Confinement Fusion (ICF) ablator materials and quantify the level of non-uniformity caused by intrinsic effects. This is done using the Omega High Resolution Velocimeter (OHRV) to obtain velocity maps of the optically reflecting shock front following release of the ablator material into either PMMA for the warm experiments or cryogenic deuterium for the cryo experiments. For the three half-days in FY17 the focus was twofold: complete measurements on the impact of oxygen heterogeneity and oxygen mitigation layers for glow discharge polymer (GDP), and begin measuring velocity non-uniformitiesmore » on deep release from Be, GDP, and highdensity carbon (HDC) into D2 with improved velocity sensitivity.« less

Special-Status Plant Species Surveys and Vegetation Mapping at Lawrence Livermore National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Preston, R E

This report presents the results of Jones & Stokes special-status plant surveys and vegetation mapping for the University of California, Lawrence Livermore National Laboratory (LLNL). Special-status plant surveys were conducted at Site 300 in April to May 1997 and in March to April 2002. Eight special-status plants were identified at Site 300: large-flowered fiddleneck, big tarplant, diamond-petaled poppy, round-leaved filaree, gypsum-loving larkspur, California androsace, stinkbells, and hogwallow starfish. Maps identifying the locations of these species, a discussion of the occurrence of these species at Site 300, and a checklist of the flora of Site 300 are presented. A reconnaissance surveymore » of the LLNL Livermore Site was conducted in June 2002. This survey concluded that no special-status plants occur at the Livermore Site. Vegetation mapping was conducted in 2001 at Site 300 to update a previous vegetation study done in 1986. The purpose of the vegetation mapping was to update and to delineate more precisely the boundaries between vegetation types and to map vegetation types that previously were not mapped. The vegetation map is presented with a discussion of the vegetation classification used.« less

Experimental Stage Separation Tool Development in NASA Langley's Aerothermodynamics Laboratory

NASA Technical Reports Server (NTRS)

Murphy, Kelly J.; Scallion, William I.

2005-01-01

As part of the research effort at NASA in support of the stage separation and ascent aerothermodynamics research program, proximity testing of a generic bimese wing-body configuration was conducted in NASA Langley's Aerothermodynamics Laboratory in the 20-Inch Mach 6 Air Tunnel. The objective of this work is the development of experimental tools and testing methodologies to apply to hypersonic stage separation problems for future multi-stage launch vehicle systems. Aerodynamic force and moment proximity data were generated at a nominal Mach number of 6 over a small range of angles of attack. The generic bimese configuration was tested in a belly-to-belly and back-to-belly orientation at 86 relative proximity locations. Over 800 aerodynamic proximity data points were taken to serve as a database for code validation. Longitudinal aerodynamic data generated in this test program show very good agreement with viscous computational predictions. Thus a framework has been established to study separation problems in the hypersonic regime using coordinated experimental and computational tools.

"They Sweat for Science": The Harvard Fatigue Laboratory and Self-Experimentation in American Exercise Physiology.

PubMed

Johnson, Andi

2015-08-01

In many scientific fields, the practice of self-experimentation waned over the course of the twentieth century. For exercise physiologists working today, however, the practice of self-experimentation is alive and well. This paper considers the role of the Harvard Fatigue Laboratory and its scientific director, D. Bruce Dill, in legitimizing the practice of self-experimentation in exercise physiology. Descriptions of self-experimentation are drawn from papers published by members of the Harvard Fatigue Lab. Attention is paid to the ethical and practical justifications for self-experimentation in both the lab and the field. Born out of the practical, immediate demands of fatigue protocols, self-experimentation performed the long-term, epistemological function of uniting physiological data across time and space, enabling researchers to contribute to a general human biology program.

The attitudes of science policy, environmental, and utility leaders on US energy issues and fusion

NASA Astrophysics Data System (ADS)

Miller, J. D.

1986-11-01

One example of basic and applied research at LLNL that has produced major, highly visible scientific and engineering advances has been the research related to controlled fusion energy. Continuing experimentation at LLNL and elsewhere is likely to demonstrate that fusion is a viable, inexhaustible alternative source of energy. Having conducted major fusion energy experiments for over 30 years at LLNL, it scientists and engineers recognized the enormous challenges that lay ahead in this important endeavor. To be successful, it was clear that collaborative efforts with universities, private industry, and other national laboratories would need to be greatly expanded. Along with invention and scientific discovery would come the challenge of transferring the myriad of new technologies from the laboratories to the private sector for commercialization of the fusion energy process and the application of related technologies to yet unimagined new industries and products. Therefore, using fusion energy research as the focus, the Laboratory's Technology Transfer Initiatives Program contracted with the Public Opinion Laboratory to conduct a survey designed to promote a better understanding of effective technology transfer. As one of the recognized authorities on scientific surveys, Dr. Jon Miller of the POL worked with Laboratory scientists to understand the objectives of the survey. He then formulated the questions, designed the survey, and derived his survey sample from a qualified list developed at the POL, which has formed the basis for other survey panels. This report, prepared by Dr. Miller, describes the basis and methodology of this survey process and then presents the survey findings and some conclusions.

Summary of International Waste Management Programs (LLNL Input to SNL L3 MS: System-Wide Integration and Site Selection Concepts for Future Disposition Options for HLW)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greenberg, Harris R.; Blink, James A.; Halsey, William G.

2011-08-11

The Used Fuel Disposition Campaign (UFDC) within the Department of Energy’s Office of Nuclear Energy (DOE-NE) Fuel Cycle Technology (FCT) program has been tasked with investigating the disposal of the nation’s spent nuclear fuel (SNF) and high-level nuclear waste (HLW) for a range of potential waste forms and geologic environments. This Lessons Learned task is part of a multi-laboratory effort, with this LLNL report providing input to a Level 3 SNL milestone (System-Wide Integration and Site Selection Concepts for Future Disposition Options for HLW). The work package number is: FTLL11UF0328; the work package title is: Technical Bases / Lessons Learned;more » the milestone number is: M41UF032802; and the milestone title is: “LLNL Input to SNL L3 MS: System-Wide Integration and Site Selection Concepts for Future Disposition Options for HLW”. The system-wide integration effort will integrate all aspects of waste management and disposal, integrating the waste generators, interim storage, transportation, and ultimate disposal at a repository site. The review of international experience in these areas is required to support future studies that address all of these components in an integrated manner. Note that this report is a snapshot of nuclear power infrastructure and international waste management programs that is current as of August 2011, with one notable exception. No attempt has been made to discuss the currently evolving world-wide response to the tragic consequences of the earthquake and tsunami that devastated Japan on March 11, 2011, leaving more than 15,000 people dead and more than 8,000 people missing, and severely damaging the Fukushima Daiichi nuclear power complex. Continuing efforts in FY 2012 will update the data, and summarize it in an Excel spreadsheet for easy comparison and assist in the knowledge management of the study cases.« less

Thermal safety characterization on PETN, PBX-9407, LX-10-2, LX-17-1 and detonator in the LLNL's P-ODTX system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hsu, P. C.; Strout, S.; Reynolds, J. G.

Incidents caused by fire and other thermal events can heat energetic materials that may lead to thermal explosion and result in structural damage and casualty. Thus, it is important to understand the response of energetic materials to thermal insults. The One-Dimensional-Time to Explosion (ODTX) system at the Lawrence Livermore National Laboratory (LLNL) has been used for decades to characterize thermal safety of energetic materials. In this study, an integration of a pressure monitoring element has been added into the ODTX system (P-ODTX) to perform thermal explosion (cook-off) experiments (thermal runaway) on PETN powder, PBX-9407, LX-10-2, LX-17-1, and detonator samples (cupmore » tests). The P-ODTX testing generates useful data (thermal explosion temperature, thermal explosion time, and gas pressures) to assist with the thermal safety assessment of relevant energetic materials and components. This report summarizes the results of P-ODTX experiments that were performed from May 2015 to July 2017. Recent upgrades to the data acquisition system allows for rapid pressure monitoring in microsecond intervals during thermal explosion. These pressure data are also included in the report.« less

The European Network of Analytical and Experimental Laboratories for Geosciences

NASA Astrophysics Data System (ADS)

Freda, Carmela; Funiciello, Francesca; Meredith, Phil; Sagnotti, Leonardo; Scarlato, Piergiorgio; Troll, Valentin R.; Willingshofer, Ernst

2013-04-01

Integrating Earth Sciences infrastructures in Europe is the mission of the European Plate Observing System (EPOS).The integration of European analytical, experimental, and analogue laboratories plays a key role in this context and is the task of the EPOS Working Group 6 (WG6). Despite the presence in Europe of high performance infrastructures dedicated to geosciences, there is still limited collaboration in sharing facilities and best practices. The EPOS WG6 aims to overcome this limitation by pushing towards national and trans-national coordination, efficient use of current laboratory infrastructures, and future aggregation of facilities not yet included. This will be attained through the creation of common access and interoperability policies to foster and simplify personnel mobility. The EPOS ambition is to orchestrate European laboratory infrastructures with diverse, complementary tasks and competences into a single, but geographically distributed, infrastructure for rock physics, palaeomagnetism, analytical and experimental petrology and volcanology, and tectonic modeling. The WG6 is presently organizing its thematic core services within the EPOS distributed research infrastructure with the goal of joining the other EPOS communities (geologists, seismologists, volcanologists, etc...) and stakeholders (engineers, risk managers and other geosciences investigators) to: 1) develop tools and services to enhance visitor programs that will mutually benefit visitors and hosts (transnational access); 2) improve support and training activities to make facilities equally accessible to students, young researchers, and experienced users (training and dissemination); 3) collaborate in sharing technological and scientific know-how (transfer of knowledge); 4) optimize interoperability of distributed instrumentation by standardizing data collection, archive, and quality control standards (data preservation and interoperability); 5) implement a unified e-Infrastructure for data

Reform of the National Security Science and Technology Enterprise

DTIC Science & Technology

2008-10-01

still attract the very best S&E talent.54 Table 1. National Academy Membership (Source: National Academies Website) ANL BNL JPL LANL LL LLNL IBM...ANL BNL JPL LANL LLNL NIH NIST NRL Articles 1023 761 705 1526 1038 4305 350 957 Government S&E Workforce—Tomorrow With the significant exception...ANL), Brookhaven National Laboratory ( BNL ), Jet Propulsion Laboratory (JPL), Lincoln Laboratory (LL), Los Alamos National Laboratory (LANL

Cold Climate Foundation Retrofit Experimental Hygrothermal Performance: Cloquet Residential Research Facility Laboratory Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goldberg, Louise F.; Harmon, Anna C.

2015-04-01

Thermal and moisture problems in existing basements create a unique challenge because the exterior face of the wall is not easily or inexpensively accessible. This approach addresses thermal and moisture management from the interior face of the wall without disturbing the exterior soil and landscaping. the interior and exterior environments. This approach has the potential for improving durability, comfort, and indoor air quality. This project was funded jointly by the National Renewable Energy Laboratory (NREL) and Oak Ridge National Laboratory (ORNL). ORNL focused on developing a full basement wall system experimental database to enable others to validate hygrothermal simulation codes.more » NREL focused on testing the moisture durability of practical basement wall interior insulation retrofit solutions for cold climates. The project has produced a physically credible and reliable long-term hygrothermal performance database for retrofit foundation wall insulation systems in zone 6 and 7 climates that are fully compliant with the performance criteria in the 2009 Minnesota Energy Code. The experimental data were configured into a standard format that can be published online and that is compatible with standard commercially available spreadsheet and database software.« less

Comparison of the LLNL ALE3D and AKTS Thermal Safety Computer Codes for Calculating Times to Explosion in ODTX and STEX Thermal Cookoff Experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wemhoff, A P; Burnham, A K

2006-04-05

Cross-comparison of the results of two computer codes for the same problem provides a mutual validation of their computational methods. This cross-validation exercise was performed for LLNL's ALE3D code and AKTS's Thermal Safety code, using the thermal ignition of HMX in two standard LLNL cookoff experiments: the One-Dimensional Time to Explosion (ODTX) test and the Scaled Thermal Explosion (STEX) test. The chemical kinetics model used in both codes was the extended Prout-Tompkins model, a relatively new addition to ALE3D. This model was applied using ALE3D's new pseudospecies feature. In addition, an advanced isoconversional kinetic approach was used in the AKTSmore » code. The mathematical constants in the Prout-Tompkins code were calibrated using DSC data from hermetically sealed vessels and the LLNL optimization code Kinetics05. The isoconversional kinetic parameters were optimized using the AKTS Thermokinetics code. We found that the Prout-Tompkins model calculations agree fairly well between the two codes, and the isoconversional kinetic model gives very similar results as the Prout-Tompkins model. We also found that an autocatalytic approach in the beta-delta phase transition model does affect the times to explosion for some conditions, especially STEX-like simulations at ramp rates above 100 C/hr, and further exploration of that effect is warranted.« less

Using experimental design modules for process characterization in manufacturing/materials processes laboratories

NASA Technical Reports Server (NTRS)

Ankenman, Bruce; Ermer, Donald; Clum, James A.

1994-01-01

Modules dealing with statistical experimental design (SED), process modeling and improvement, and response surface methods have been developed and tested in two laboratory courses. One course was a manufacturing processes course in Mechanical Engineering and the other course was a materials processing course in Materials Science and Engineering. Each module is used as an 'experiment' in the course with the intent that subsequent course experiments will use SED methods for analysis and interpretation of data. Evaluation of the modules' effectiveness has been done by both survey questionnaires and inclusion of the module methodology in course examination questions. Results of the evaluation have been very positive. Those evaluation results and details of the modules' content and implementation are presented. The modules represent an important component for updating laboratory instruction and to provide training in quality for improved engineering practice.

Special Analysis for the Disposal of the Lawrence Livermore National Laboratory Low Activity Beta/Gamma Sources Waste Stream at the Area 5 Radioactive Waste Management Site, Nevada National Security Site, Nye County, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shott, Gregory J.

This special analysis (SA) evaluates whether the Lawrence Livermore National Laboratory (LLNL) Low Activity Beta/Gamma Sources waste stream (BCLALADOEOSRP, Revision 0) is suitable for disposal by shallow land burial (SLB) at the Area 5 Radioactive Waste Management Site (RWMS) at the Nevada National Security Site (NNSS). The LLNL Low Activity Beta/Gamma Sources waste stream consists of sealed sources that are no longer needed. The LLNL Low Activity Beta/Gamma Sources waste stream required a special analysis because cobalt-60 (60Co), strontium-90 (90Sr), cesium-137 (137Cs), and radium-226 (226Ra) exceeded the NNSS Waste Acceptance Criteria (WAC) Action Levels (U.S. Department of Energy, National Nuclearmore » Security Administration Nevada Field Office [NNSA/NFO] 2015). The results indicate that all performance objectives can be met with disposal of the LLNL Low Activity Beta/Gamma Sources in a SLB trench. The LLNL Low Activity Beta/Gamma Sources waste stream is suitable for disposal by SLB at the Area 5 RWMS. However, the activity concentration of 226Ra listed on the waste profile sheet significantly exceeds the action level. Approval of the waste profile sheet could potentially allow the disposal of high activity 226Ra sources. To ensure that the generator does not include large 226Ra sources in this waste stream without additional evaluation, a control is need on the maximum 226Ra inventory. A limit based on the generator’s estimate of the total 226Ra inventory is recommended. The waste stream is recommended for approval with the control that the total 226Ra inventory disposed shall not exceed 5.5E10 Bq (1.5 Ci).« less

Experimental MERS Treatment Deemed Safe in Phase I Clinical Trial | Frederick National Laboratory for Cancer Research

Cancer.gov

A small clinical study overseen by the National Institute of Allergy and Infectious Diseases (NIAID) with support from the Frederick National Laboratory for Cancer Research has found that an experimental treatment for Middle East Respiratory Syndrome

Archive and laboratory embedded in the landscape: Future of the Santa Rita Experimental Range

Treesearch

Thomas E. Sheridan

2003-01-01

The Santa Rita Experimental Range (SRER) is both an archive of past ecological research and a laboratory for continuing research embedded in the southern Arizona landscape. The scientific questions being asked there have changed over the last 100 years, but SRER with its monitoring stations and its legacy of repeat photography still offers a unique opportunity to study...

Determination of Soil Moisture Content using Laboratory Experimental and Field Electrical Resistivity Values

NASA Astrophysics Data System (ADS)

Hazreek, Z. A. M.; Rosli, S.; Fauziah, A.; Wijeyesekera, D. C.; Ashraf, M. I. M.; Faizal, T. B. M.; Kamarudin, A. F.; Rais, Y.; Dan, M. F. Md; Azhar, A. T. S.; Hafiz, Z. M.

2018-04-01

The efficiency of civil engineering structure require comprehensive geotechnical data obtained from site investigation. In the past, conventional site investigation was heavily related to drilling techniques thus suffer from several limitations such as time consuming, expensive and limited data collection. Consequently, this study presents determination of soil moisture content using laboratory experimental and field electrical resistivity values (ERV). Field and laboratory electrical resistivity (ER) test were performed using ABEM SAS4000 and Nilsson400 soil resistance meter. Soil sample used for resistivity test was tested for characterization test specifically on particle size distribution and moisture content test according to BS1377 (1990). Field ER data was processed using RES2DINV software while laboratory ER data was analyzed using SPSS and Excel software. Correlation of ERV and moisture content shows some medium relationship due to its r = 0.506. Moreover, coefficient of determination, R2 analyzed has demonstrate that the statistical correlation obtain was very good due to its R2 value of 0.9382. In order to determine soil moisture content based on statistical correlation (w = 110.68ρ-0.347), correction factor, C was established through laboratory and field ERV given as 19.27. Finally, this study has shown that soil basic geotechnical properties with particular reference to water content was applicably determined using integration of laboratory and field ERV data analysis thus able to compliment conventional approach due to its economic, fast and wider data coverage.

IGPP 1999-2000 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ryerson, F J; Cook, K; Hitchcock, B

2003-01-27

and geochemistry. The Astrophysics Research Center, headed by Kem Cook, provides a home for theoretical and observational astrophysics and serves as an interface with the Physics Directorate's astrophysics efforts. At the end of the period covered by this report, Alcock left for the University of Pennsylvania. Cook became Acting Director of IGPP, the Physics Direcorate merged with portions of the old Lasers Direcorate to become Physics and Advanced Technologies. Energy Programs and Earth and Environmental Sciences Directorate became Energy and Environment Sciences Directorate. The IGPP branch at LLNL (as well as the branch at Los Alamos) also facilitates scientific collaborations between researchers at the UC campuses and those at the national laboratories in areas related to earth science, planetary science, and astrophysics. It does this by sponsoring the University Collaborative Research Program (UCRP), which provides funds to UC campus scientists for joint research projects with LLNL. Additional information regarding IGPP-LLNL projects and people may be found at http://wwwigpp. llnl.gov/. The goals of the UCRP are to enrich research opportunities for UC campus scientists by making available to them some of LLNL's unique facilities and expertise, and to broaden the scientific program at LLNL through collaborative or interdisciplinary work with UC campus researchers. UCRP funds (provided jointly by the Regents of the University of California and by the Director of LLNL) are awarded annually on the basis of brief proposals, which are reviewed by a committee of scientists from UC campuses, LLNL programs, and external universities and research organizations. Typical annual funding for a collaborative research project ranges from $5,000 to $30,000. Funds are used for a variety of purposes, such as salary support for UC graduate students, postdoctoral fellows; and costs for experimental facilities. A statistical overview of IGPP-LLNL's UCRP (colloquially known as the

Proceedings of the 5. joint Russian-American computational mathematics conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-12-31

These proceedings contain a record of the talks presented and papers submitted by participants. The conference participants represented three institutions from the United States, Sandia National Laboratories (SNL), Los Alamos National Laboratory (LANL), Lawrence Livermore National Laboratory (LLNL), and two from Russia, Russian Federal Nuclear Center--All Russian Research Institute of Experimental Physics (RFNC-VNIIEF/Arzamas-16), and Russian Federal Nuclear Center--All Russian Research Institute of Technical Physics (RFNC-VNIITF/Chelyabinsk-70). The presentations and papers cover a wide range of applications from radiation transport to materials. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database.

Instructor qualification for radiation safety training at a national laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trinoskey, P.A.

1994-10-01

Prior to 1993, Health Physics Training (HPT) was conducted by the Lawrence Livermore National Laboratory (LLNL) health physics group. The job requirements specified a Masters Degree and experience. In fact, the majority of Health Physicists in the group were certified by the American Board of Health Physics. Under those circumstances, it was assumed that individuals in the group were technically qualified and the HPT instructor qualification stated that. In late 1993, the Health Physics Group at the LLNL was restructured and the training function was assigned to the training group. Additional requirements for training were mandated by the Department ofmore » Energy (DOE), which would necessitate increasing the existing training staff. With the need to hire, and the policy of reassignment of employees during downsizing, it was imperative that formal qualification standards be developed for technical knowledge. Qualification standards were in place for instructional capability. In drafting the new training qualifications for instructors, the requirements of a Certified Health Physicists had to be modified due to supply and demand. Additionally, for many of the performance-based training courses, registration by the National Registry of Radiation Protection Technologists is more desirable. Flexibility in qualification requirements has been incorporated to meet the reality of ongoing training and the compensation for desirable skills of individuals who may not meet all the criteria. The qualification requirements for an instructor rely on entry-level requirements and emphasis on goals (preferred) and continuing development of technical and instructional capabilities.« less

FY2007 Laboratory Directed Research and Development Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Craig, W W; Sketchley, J A; Kotta, P R

The Laboratory Directed Research and Development (LDRD) annual report for fiscal year 2007 (FY07) provides a summary of LDRD-funded projects for the fiscal year and consists of two parts: An introduction to the LDRD Program, the LDRD portfolio-management process, program statistics for the year, and highlights of accomplishments for the year. A summary of each project, submitted by the principal investigator. Project summaries include the scope, motivation, goals, relevance to Department of Energy (DOE)/National Nuclear Security Administration (NNSA) and Lawrence Livermore National Laboratory (LLNL) mission areas, the technical progress achieved in FY07, and a list of publications that resulted frommore » the research in FY07. Summaries are organized in sections by research category (in alphabetical order). Within each research category, the projects are listed in order of their LDRD project category: Strategic Initiative (SI), Exploratory Research (ER), Laboratory-Wide Competition (LW), and Feasibility Study (FS). Within each project category, the individual project summaries appear in order of their project tracking code, a unique identifier that consists of three elements. The first is the fiscal year the project began, the second represents the project category, and the third identifies the serial number of the proposal for that fiscal year.« less

LLNL Location and Detection Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Myers, S C; Harris, D B; Anderson, M L

2003-07-16

We present two LLNL research projects in the topical areas of location and detection. The first project assesses epicenter accuracy using a multiple-event location algorithm, and the second project employs waveform subspace Correlation to detect and identify events at Fennoscandian mines. Accurately located seismic events are the bases of location calibration. A well-characterized set of calibration events enables new Earth model development, empirical calibration, and validation of models. In a recent study, Bondar et al. (2003) develop network coverage criteria for assessing the accuracy of event locations that are determined using single-event, linearized inversion methods. These criteria are conservative andmore » are meant for application to large bulletins where emphasis is on catalog completeness and any given event location may be improved through detailed analysis or application of advanced algorithms. Relative event location techniques are touted as advancements that may improve absolute location accuracy by (1) ensuring an internally consistent dataset, (2) constraining a subset of events to known locations, and (3) taking advantage of station and event correlation structure. Here we present the preliminary phase of this work in which we use Nevada Test Site (NTS) nuclear explosions, with known locations, to test the effect of travel-time model accuracy on relative location accuracy. Like previous studies, we find that the reference velocity-model and relative-location accuracy are highly correlated. We also find that metrics based on travel-time residual of relocated events are not a reliable for assessing either velocity-model or relative-location accuracy. In the topical area of detection, we develop specialized correlation (subspace) detectors for the principal mines surrounding the ARCES station located in the European Arctic. Our objective is to provide efficient screens for explosions occurring in the mines of the Kola Peninsula (Kovdor

Sub-picosecond streak camera measurements at LLNL: From IR to x-rays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuba, J; Shepherd, R; Booth, R

An ultra fast, sub-picosecond resolution streak camera has been recently developed at the LLNL. The camera is a versatile instrument with a wide operating wavelength range. The temporal resolution of up to 300 fs can be achieved, with routine operation at 500 fs. The streak camera has been operated in a wide wavelength range from IR to x-rays up to 2 keV. In this paper we briefly review the main design features that result in the unique properties of the streak camera and present its several scientific applications: (1) Streak camera characterization using a Michelson interferometer in visible range, (2)more » temporally resolved study of a transient x-ray laser at 14.7 nm, which enabled us to vary the x-ray laser pulse duration from {approx}2-6 ps by changing the pump laser parameters, and (3) an example of a time-resolved spectroscopy experiment with the streak camera.« less

Fixatives Application for Risk Mitigation Following Contamination with a Biological Agent

DTIC Science & Technology

2011-11-02

PRES-  Gruinard Island 5% formaldehyde  Sverdlosk Release UNKNOWN: but washing, chloramines , soil disposal believed to have been used...507816 Lawrence Livermore National Laboratory LLNL-PRES- 4 Disinfectant >6 Log Reduction on Materials (EPA, 2010a,b; Wood et al., 2011...LL L-PRES-507816 Lawrence Livermore National Laboratory LLNL-PRES-  High disinfectant concentrations increase operational costs and risk

Lawrence Livermore National Laboratory and Sandia National Laboratory Nuclear Accident Dosimetry Support of IER 252 and the Dose Characterization of the Flattop Reactor at the DAF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hickman, D. P.; Jeffers, K. L.; Radev, R. P.

In support of IER 252 “Characterization of the Flattop Reactor at the NCERC”, LLNL performed ROSPEC measurements of the neutron spectrum and deployed 129 Personnel Nuclear Accident Dosimeters (PNAD) to establish the need for height corrections and verification of neutron spectrum evaluation of the fluences and dose. A very limited number of heights (typically only one or two heights) can be measured using neutron spectrometers, therefore it was important to determine if any height correction would be needed in future intercomparisons and studies. Specific measurement positions around the Flatttop reactor are provided in Figure 1. Table 1 provides run andmore » position information for LLNL measurements. The LLNL ROSPEC (R2) was used for run numbers 1 – 7, and vi. PNADs were positioned on trees during run numbers 9, 11, and 13.« less

Gold Spectra Measurements from LLNL EBIT Plasmas

NASA Astrophysics Data System (ADS)

May, M.; Brown, G. V.; Chen, H.; Chung, H. K.; Gu, M.; Hansen, S. B.; Schneider, M. B.; Widmann, K.; Beiersdorfer, P.

2008-11-01

Spectra have been recorded from gold that has been injected into the Lawrence Livermore Electron Beam Ion Trap (EBIT-II). Both mono-energetic and experimentally simulated Maxwell-Boltzmann (MB) plasmas were created for these measurements. The beam plasmas had energies of 2.75, 3.0, 3.6, 4.6, 5.5, 6.0, 6.5 keV. The MB plasmas had electron temperatures of 2.0, 2.5 and 3.0 keV. M-band gold spectra (n = 4-3, 5-3, 6-3 and 7-3 transitions) were recorded between 1 - 8 keV from K-like to Kr-like ions in the x-ray. The emission of gold was recorded by crystal spectrometers and a micro-calorimeter from the Goddard Space Flight Center. A full survey of the recorded spectra will be presented along with line emission and charge state modeling from the flexible atomic code (FAC). Some comparisons with laser produced plasmas will be made. *This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

ISCR FY2005 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keyes, D E; McGraw, J R

2006-02-02

Large-scale scientific computation and all of the disciplines that support and help validate it have been placed at the focus of Lawrence Livermore National Laboratory (LLNL) by the Advanced Simulation and Computing (ASC) program of the National Nuclear Security Administration (NNSA) and the Scientific Discovery through Advanced Computing (SciDAC) initiative of the Office of Science of the Department of Energy (DOE). The maturation of simulation as a fundamental tool of scientific and engineering research is underscored in the President's Information Technology Advisory Committee (PITAC) June 2005 finding that ''computational science has become critical to scientific leadership, economic competitiveness, and nationalmore » security''. LLNL operates several of the world's most powerful computers--including today's single most powerful--and has undertaken some of the largest and most compute-intensive simulations ever performed, most notably the molecular dynamics simulation that sustained more than 100 Teraflop/s and won the 2005 Gordon Bell Prize. Ultrascale simulation has been identified as one of the highest priorities in DOE's facilities planning for the next two decades. However, computers at architectural extremes are notoriously difficult to use in an efficient manner. Furthermore, each successful terascale simulation only points out the need for much better ways of interacting with the resulting avalanche of data. Advances in scientific computing research have, therefore, never been more vital to the core missions of LLNL than at present. Computational science is evolving so rapidly along every one of its research fronts that to remain on the leading edge, LLNL must engage researchers at many academic centers of excellence. In FY 2005, the Institute for Scientific Computing Research (ISCR) served as one of LLNL's main bridges to the academic community with a program of collaborative subcontracts, visiting faculty, student internships, workshops, and an

ISCR Annual Report: Fical Year 2004

DOE Office of Scientific and Technical Information (OSTI.GOV)

McGraw, J R

2005-03-03

Large-scale scientific computation and all of the disciplines that support and help to validate it have been placed at the focus of Lawrence Livermore National Laboratory (LLNL) by the Advanced Simulation and Computing (ASC) program of the National Nuclear Security Administration (NNSA) and the Scientific Discovery through Advanced Computing (SciDAC) initiative of the Office of Science of the Department of Energy (DOE). The maturation of computational simulation as a tool of scientific and engineering research is underscored in the November 2004 statement of the Secretary of Energy that, ''high performance computing is the backbone of the nation's science and technologymore » enterprise''. LLNL operates several of the world's most powerful computers--including today's single most powerful--and has undertaken some of the largest and most compute-intensive simulations ever performed. Ultrascale simulation has been identified as one of the highest priorities in DOE's facilities planning for the next two decades. However, computers at architectural extremes are notoriously difficult to use efficiently. Furthermore, each successful terascale simulation only points out the need for much better ways of interacting with the resulting avalanche of data. Advances in scientific computing research have, therefore, never been more vital to LLNL's core missions than at present. Computational science is evolving so rapidly along every one of its research fronts that to remain on the leading edge, LLNL must engage researchers at many academic centers of excellence. In Fiscal Year 2004, the Institute for Scientific Computing Research (ISCR) served as one of LLNL's main bridges to the academic community with a program of collaborative subcontracts, visiting faculty, student internships, workshops, and an active seminar series. The ISCR identifies researchers from the academic community for computer science and computational science collaborations with LLNL and hosts them for short

Addressing Transportation Energy and Environmental Impacts: Technical and Policy Research Directions

DOT National Transportation Integrated Search

1995-08-10

The Lawrence Livermore National Laboratory (LLNL) is establishing a local chapter of the University of California Energy Institute (UCEI). In order to most effectively contribute to the Institute, LLNL sponsored a workshop on energy and environmental...

A Report of the Joint Development of a Prototype Communications Link to Share Nuclear Accident Dispersion and Dose Assessment Modeling Products Between JAERI/WSPEEDI and LLNL/NARAC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sullivan, T J; Belles, R D; Ellis, J S

2001-05-01

In June of 1997, under an umbrella Memorandum of Understanding between the Japan Atomic Energy Research Institute (JAERI) and the U.S. Department of Energy (US/DOE) concerning matters of nuclear research and development, a Specific Memorandum of Agreement (SMA) entitled ''A Collaborative Programme of Development of a Prototype Communication Link to Share Atmospheric Dispersion and Dose Assessment Modelling Products'' was signed. This SMA formalized an informal collaborative exchange between the DOE's Lawrence Livermore National Laboratory (LLNL) Atmospheric Release Advisory Capability (ARAC) center and the Japan Atomic Energy Research Institute (JAERI) Worldwide System for Prediction of Environmental Emergency Dose Information (WSPEEDI). Themore » intended objective of this agreement was to explore various modes of information exchange, beyond facsimile transmission, which could provide for the quick exchange of information between two major nuclear emergency dose assessment and prediction national centers to provide consistency checks and data exchange before public release of their calculations. The extreme sensitivity of the general public to any nuclear accident information has been a strong motivation to seek peer preview prior to public release. Other intended objectives of this work are the development of an affordable/accessible system for distribution of prediction results to other countries having no prediction capabilities and utilization of the link for collaboration studies. To fulfill the objectives of this project JAERI and LLNL scientists determined to assess the evolving Internet and rapidly emerging communications application software. Our timing was a little early in 1997-1998 but nonetheless a few candidate software packages were found, evaluated and a selection was made for initial test and evaluation. Subsequently several new candidate software packages have arrived, albeit with limitations. This report outlines the ARAC and JAERI emergency

Translational experimental therapeutics: The translation of laboratory-based discovery into disease-related therapy.

PubMed

Kieburtz, Karl; Olanow, C Warren

2007-04-01

In the past decade, there has been an increasing emphasis on laboratory-based translational research. This has led to significant scientific advances in our understanding of disease mechanisms and in the development of novel approaches to therapy such as gene therapy, RNA interference, and stem cells. However, the translation of these remarkable scientific achievements into new and effective disease-modifying therapies has lagged behind these scientific accomplishments. We use the term "translational experimental therapeutics" to describe the pathway between the discovery of a basic disease mechanism or novel therapeutic approach and its translation into an effective treatment for patients with a specific disease. In this article, we review the components of this pathway, and discuss issues that might impede this process. Only by optimizing this pathway can we realize the full therapeutic potential of current scientific discoveries and translate the astounding advances that have been accomplished in the laboratory into effective treatments for our patients. Copyright (c) 2007 Mount Sinai School of Medicine.

Laboratory model of the cardiovascular system for experimental demonstration of pulse wave propagation

NASA Astrophysics Data System (ADS)

Stojadinović, Bojana; Nestorović, Zorica; Djurić, Biljana; Tenne, Tamar; Zikich, Dragoslav; Žikić, Dejan

2017-03-01

The velocity by which a disturbance moves through the medium is the wave velocity. Pulse wave velocity is among the key parameters in hemodynamics. Investigation of wave propagation through the fluid-filled elastic tube has a great importance for the proper biophysical understanding of the nature of blood flow through the cardiovascular system. Here, we present a laboratory model of the cardiovascular system. We have designed an experimental setup which can help medical and nursing students to properly learn and understand basic fluid hemodynamic principles, pulse wave and the phenomenon of wave propagation in blood vessels. Demonstration of wave propagation allowed a real time observation of the formation of compression and expansion waves by students, thus enabling them to better understand the difference between the two waves, and also to measure the pulse wave velocity for different fluid viscosities. The laboratory model of the cardiovascular system could be useful as an active learning methodology and a complementary tool for understanding basic principles of hemodynamics.

Development of Operational Free-Space-Optical (FSO) Laser Communication Systems Final Report CRADA No. TC02093.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruggiero, A.; Orgren, A.

This project was a collaborative effort between Lawrence Livermore National Security, LLC (formerly The Regents of the University of California)/Lawrence Livermore National Laboratory (LLNL) and LGS Innovations, LLC (formerly Lucent Technologies, Inc.), to develop long-range and mobile operational free-space optical (FSO) laser communication systems for specialized government applications. LLNL and LGS Innovations formerly Lucent Bell Laboratories Government Communications Systems performed this work for a United States Government (USG) Intelligence Work for Others (I-WFO) customer, also referred to as "Government Customer", or "Customer" and "Government Sponsor." The CRADA was a critical and required part of the LLNL technology transfer plan formore » the customer.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, C.; Arsenlis, T.; Bailey, A.

Lawrence Livermore National Laboratory Campus Capability Plan for 2018-2028. Lawrence Livermore National Laboratory (LLNL) is one of three national laboratories that are part of the National Nuclear Security Administration. LLNL provides critical expertise to strengthen U.S. security through development and application of world-class science and technology that: Ensures the safety, reliability, and performance of the U.S. nuclear weapons stockpile; Promotes international nuclear safety and nonproliferation; Reduces global danger from weapons of mass destruction; Supports U.S. leadership in science and technology. Essential to the execution and continued advancement of these mission areas are responsive infrastructure capabilities. This report showcases each LLNLmore » capability area and describes the mission, science, and technology efforts enabled by LLNL infrastructure, as well as future infrastructure plans.« less

Architectural Analysis of a LLNL LWIR Sensor System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bond, Essex J.; Curry, Jim R.; LaFortune, Kai N.

The architecture of an LLNL airborne imaging and detection system is considered in this report. The purpose of the system is to find the location of substances of interest by detecting their chemical signatures using a long-wave infrared (LWIR) imager with geo-registration capability. The detection system consists of an LWIR imaging spectrometer as well as a network of computer hardware and analysis software for analyzing the images for the features of interest. The system has been in the operations phase now for well over a year, and as such, there is enough use data and feedback from the primary beneficiarymore » to assess the current successes and shortcomings of the LWIR system architecture. LWIR system has been successful in providing reliable data collection and the delivery of a report with results. The weakness of the architecture has been identified in two areas: with the network of computer hardware and software and with the feedback of the state of the system health. Regarding the former, the system computers and software that carry out the data acquisition are too complicated for routine operations and maintenance. With respect to the latter, the primary beneficiary of the instrument’s data does not have enough metrics to use to filter the large quantity of data to determine its utility. In addition to the needs in these two areas, a latent need of one of the stakeholders is identified. This report documents the strengths and weaknesses, as well as proposes a solution for enhancing the architecture that simultaneously addresses the two areas of weakness and leverages them to meet the newly identified latent need.« less

Detailed characterization of the LLNL imaging proton spectrometer

DOE PAGES

Rasmus, A. M.; Hazi, A. U.; Manuel, M. J. -E.; ...

2016-09-01

Here, ultra-intense short pulse lasers incident on solid targets (e.g., several um thick Au foils) produce well collimated, broad-energy-spectrum proton beams. These proton beams can be used to characterize magnetic fields, electric fields (through particle deflection), and density gradients (through collisions) in high energy-density systems. The LLNL-Imaging Proton Spectrometer (L-IPS) was designed and built for use with such laser produced proton beams. The L-IPS has an energy range of 50 keV-40 MeV with a resolving power (E/dE) of about 275 at 1 MeV and 21 at 20 MeV, as well as a single spatial imaging axis. The protons enter themore » diagnostic through a vertical slit, aligned with a magnetic field imposed by permanent magnets. The protons are deflected perpendicular to the magnetic field (and therefor slit), so that spatial information in the direction of the slit is preserved. The extent to which the protons are bent by the magnetic field depends on the energy, so that the energy of the protons can be resolved as well. The protons are then measured by image plates, in which a meta-stable state is excited by collisions with the protons, which can later be imaged by a scanner. In order to better characterize the dispersion and imaging capability of this diagnostic, a 3D finite element analysis solver is used to calculate the magnetic field of the L-IPS. Particle trajectories are then obtained via numerical integration to determine the dispersion relation of the L-IPS in both energy and angular space.« less

FY 2008 Next Generation Safeguards Initiative International Safeguards Education and Training Pilot Progerams Summary Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dreicer, M; Anzelon, G; Essner, J

2008-10-17

Key component of the Next Generation Safeguards Initiative (NGSI) launched by the National Nuclear Security Administration is the development of human capital to meet present and future challenges to the safeguards regime. An effective university-level education in safeguards and related disciplines is an essential element in a layered strategy to rebuild the safeguards human resource capacity. Two pilot programs at university level, involving 44 students, were initiated and implemented in spring-summer 2008 and linked to hands-on internships at LANL or LLNL. During the internships, students worked on specific safeguards-related projects with a designated Laboratory Mentor to provide broader exposure tomore » nuclear materials management and information analytical techniques. The Safeguards and Nuclear Material Management pilot program was a collaboration between the Texas A&M University (TAMU), Los Alamos National Laboratory (LANL) and Lawrence Livermore National Laboratory (LLNL). It included a 16-lecture course held during a summer internship program. The instructors for the course were from LANL together with TAMU faculty and LLNL experts. The LANL-based course was shared with the students spending their internship at LLNL via video conference. A week-long table-top (or hands-on) exercise on was also conducted at LANL. The student population was a mix of 28 students from a 12 universities participating in a variety of summer internship programs held at LANL and LLNL. A large portion of the students were TAMU students participating in the NGSI pilot. The International Nuclear Safeguards Policy and Information Analysis pilot program was implemented at the Monterey Institute for International Studies (MIIS) in cooperation with LLNL. It included a two-week intensive course consisting of 20 lectures and two exercises. MIIS, LLNL, and speakers from other U.S. national laboratories (LANL, BNL) delivered lectures for the audience of 16 students. The majority of

2002 Small Mammal Inventory at Lawrence Livermore National Laboratory, Site 300

DOE Office of Scientific and Technical Information (OSTI.GOV)

West, E; Woollett, J

2004-11-16

To assist the University of California in obtaining biological assessment information for the ''2004 Environmental Impact Statement for Continued Operation of Lawrence Livermore National Laboratory (LLNL)'', Jones & Stokes conducted an inventory of small mammals in six major vegetation communities at Site 300. These communities were annual grassland, native grassland, oak savanna, riparian corridor, coastal scrub, and seep/spring wetlands. The principal objective of this study was to assess the diversity and abundance of small mammal species in these communities, as well as the current status of any special-status small mammal species found in these communities. Surveys in the native grasslandmore » community were conducted before and after a controlled fire management burn of the grasslands to qualitatively evaluate any potential effects of fire on small mammals in the area.« less

A laboratory exercise in experimental bioimmuration

USGS Publications Warehouse

Mankiewicz, C.

1998-01-01

A paleobiologic laboratory exercise using lunch meat, cheeses, and condiments provides a means for studying a method of fossil preservation called "bioimmuration." The exercise also has students deal with problems associated with other aspects of taphonomy, taxonomy, and paleoecology.

Demonstration of Regional Discrimination of Eurasian Seismic Events Using Observations at Soviet IRIS and CDSN Stations

DTIC Science & Technology

1992-03-01

Propagation of Lg Waves Across Eastern Europe and Asia, Lawrence Livermore National Laboratory Report, LLNL Report No. UCRL -52494. Press, F., and M. Ewing...the Nuclear Testing Ground in Eastern Kazakhstan, Lawrence Livermore National Laboratory Report, LLNL Report No. UCRL -52856. Ruzaikin, A., I. Nersesov...Derring Hall University Park, PA 16802 Blacksburg, VA 24061 Dr. Ralph Alewine, III Dr. Stephen Bratt DARPAftMRO Center for Seismic Studies 3701 North Fairax

An experimental topographic amplification study at Los Alamos National Laboratory using ambient vibrations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stolte, Andrew C.; Cox, Brady R.; Lee, Richard C.

An experimental study aimed at investigating potential topographic amplification of seismic waves was conducted on a 50-m-tall and 185-m-wide soft-rock ridge located at Los Alamos National Laboratory near Los Alamos, New Mexico. Ten portable broadband seismograph stations were placed in arrays across the ridge and left to record ambient vibration data for ~9 hours. Clear evidence of topographic amplification was observed by comparing spectral ratios calculated from ambient noise recordings at the toe, slope, and crest of the instrumented ridge. The inferred resonance frequency of the ridge obtained from the experimental recordings was found to agree well with several simplemore » estimates of the theoretical resonance frequency based on its geometry and stiffness. Results support the feasibility of quantifying the frequency range of topographic amplification solely using ambient vibrations, rather than strong or weak ground motions. Additionally, comparisons have been made between a number of widely used experimental methods for quantifying topographic effects, such as the standard spectral ratio, median reference method, and horizontal-to-vertical spectral ratio. As a result, differences in the amplification and frequency range of topographic effects indicated by these methods highlight the importance of choosing a reference condition that is appropriate for the site-specific conditions and goals associated with an experimental topographic amplification study.« less

An experimental topographic amplification study at Los Alamos National Laboratory using ambient vibrations

DOE PAGES

Stolte, Andrew C.; Cox, Brady R.; Lee, Richard C.

2017-03-14

An experimental study aimed at investigating potential topographic amplification of seismic waves was conducted on a 50-m-tall and 185-m-wide soft-rock ridge located at Los Alamos National Laboratory near Los Alamos, New Mexico. Ten portable broadband seismograph stations were placed in arrays across the ridge and left to record ambient vibration data for ~9 hours. Clear evidence of topographic amplification was observed by comparing spectral ratios calculated from ambient noise recordings at the toe, slope, and crest of the instrumented ridge. The inferred resonance frequency of the ridge obtained from the experimental recordings was found to agree well with several simplemore » estimates of the theoretical resonance frequency based on its geometry and stiffness. Results support the feasibility of quantifying the frequency range of topographic amplification solely using ambient vibrations, rather than strong or weak ground motions. Additionally, comparisons have been made between a number of widely used experimental methods for quantifying topographic effects, such as the standard spectral ratio, median reference method, and horizontal-to-vertical spectral ratio. As a result, differences in the amplification and frequency range of topographic effects indicated by these methods highlight the importance of choosing a reference condition that is appropriate for the site-specific conditions and goals associated with an experimental topographic amplification study.« less

Inertial Confinement Fusion Annual Report 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Correll, D

. We also provide a short summary of the quarterly activities within Nova laser operations, Beamlet laser operations, and National Ignition Facility laser design. LLNL's ICF Program falls within DOE's national ICF program, which includes the Nova and Beamlet (LLNL), OMEGA (University of Rochester Laboratory for Laser Energetics), Nike (Naval Research Laboratory), and Trident (Los Alamos National Laboratory) laser facilities. The Particle Beam Fusion Accelerator (Z) and Saturn pulsed-power facilities are at Sandia National Laboratories. General Atomics, Inc., develops and provides many of the targets for the above experimental facilities. Many of the ICF Annual Report articles are co-authored with our colleagues from these other ICF institutions.« less

Spherical harmonic results for the 3D Kobayashi Benchmark suite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, P N; Chang, B; Hanebutte, U R

1999-03-02

Spherical harmonic solutions are presented for the Kobayashi benchmark suite. The results were obtained with Ardra, a scalable, parallel neutron transport code developed at Lawrence Livermore National Laboratory (LLNL). The calculations were performed on the IBM ASCI Blue-Pacific computer at LLNL.

Environmental Report 1993-1996

DOT National Transportation Integrated Search

2002-08-16

These reports are prepared for the U.S. Department of Energy (DOE), as required by DOE Order 5400.1 and DOE Order 231.1, by the Environmental Protection Department (EPD) at the Lawrence Livermore National Laboratory (LLNL). The results of LLNL's envi...

Environmental Report 2008

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gallegos, G; Bertoldo, N A; Campbell, C G

The purposes of the Lawrence Livermore National Laboratory Environmental Report 2008 are to record Lawrence Livermore National Laboratory's (LLNL's) compliance with environmental standards and requirements, describe LLNL's environmental protection and remediation programs, and present the results of environmental monitoring at the two LLNL sites - the Livermore site and Site 300. The report is prepared for the U.S. Department of Energy (DOE) by LLNL's Environmental Protection Department. Submittal of the report satisfies requirements under DOE Order 231.1A, Environmental Safety and Health Reporting, and DOE Order 5400.5, Radiation Protection of the Public and Environment. The report is distributed electronically and ismore » available at https://saer.lln.gov/, the website for the LLNL annual environmental report. Previous LLNL annual environmental reports beginning in 1994 are also on the website. Some references in the electronic report text are underlined, which indicates that they are clickable links. Clicking on one of these links will open the related document, data workbook, or website that it refers to. The report begins with an executive summary, which provides the purpose of the report and an overview of LLNL's compliance and monitoring results. The first three chapters provide background information: Chapter 1 is an overview of the location, meteorology, and hydrogeology of the two LLNL sites; Chapter 2 is a summary of LLNL's compliance with environmental regulations; and Chapter 3 is a description of LLNL's environmental programs with an emphasis on the Environmental Management System including pollution prevention. The majority of the report covers LLNL's environmental monitoring programs and monitoring data for 2008: effluent and ambient air (Chapter 4); waters, including wastewater, storm water runoff, surface water, rain, and groundwater (Chapter 5); and terrestrial, including soil, sediment, vegetation, foodstuff, ambient radiation, and special

An Approach to Industrial Stormwater Benchmarks: Establishing and Using Site-Specific Threshold Criteria at Lawrence Livermore National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Campbell, C G; Mathews, S

2006-09-07

Current regulatory schemes use generic or industrial sector specific benchmarks to evaluate the quality of industrial stormwater discharges. While benchmarks can be a useful tool for facility stormwater managers in evaluating the quality stormwater runoff, benchmarks typically do not take into account site-specific conditions, such as: soil chemistry, atmospheric deposition, seasonal changes in water source, and upstream land use. Failing to account for these factors may lead to unnecessary costs to trace a source of natural variation, or potentially missing a significant local water quality problem. Site-specific water quality thresholds, established upon the statistical evaluation of historic data take intomore » account these factors, are a better tool for the direct evaluation of runoff quality, and a more cost-effective trigger to investigate anomalous results. Lawrence Livermore National Laboratory (LLNL), a federal facility, established stormwater monitoring programs to comply with the requirements of the industrial stormwater permit and Department of Energy orders, which require the evaluation of the impact of effluent discharges on the environment. LLNL recognized the need to create a tool to evaluate and manage stormwater quality that would allow analysts to identify trends in stormwater quality and recognize anomalous results so that trace-back and corrective actions could be initiated. LLNL created the site-specific water quality threshold tool to better understand the nature of the stormwater influent and effluent, to establish a technical basis for determining when facility operations might be impacting the quality of stormwater discharges, and to provide ''action levels'' to initiate follow-up to analytical results. The threshold criteria were based on a statistical analysis of the historic stormwater monitoring data and a review of relevant water quality objectives.« less

Space Weathering in Houston: A Role for the Experimental Impact Laboratory at JSC

NASA Technical Reports Server (NTRS)

Cintala, M. J.; Keller, L. P.; Christoffersen, R.; Hoerz, F.

2015-01-01

The effective investigation of space weathering demands an interdisciplinary approach that is at least as diversified as any other in planetary science. Because it is a macroscopic process affecting all bodies in the solar system, impact and its resulting shock effects must be given detailed attention in this regard. Direct observation of the effects of impact is most readily done for the Moon, but it still remains difficult for other bodies in the solar system. Analyses of meteorites and precious returned samples provide clues for space weathering on asteroids, but many deductions arising from those studies must still be considered circumstantial. Theoretical work is also indispensable, but it can only go as far as the sometimes meager data allow. Experimentation, however, can permit near real-time study of myriad processes that could contribute to space weathering. This contribution describes some of the capabilities of the Johnson Space Center's Experimental Impact Laboratory (EIL) and how they might help in understanding the space weathering process.

International Safeguards Technology and Policy Education and Training Pilot Programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dreicer, M; Anzelon, G A; Essner, J T

2009-06-16

A major focus of the National Nuclear Security Administration-led Next Generation Safeguards Initiative (NGSI) is the development of human capital to meet present and future challenges to the safeguards regime. An effective university-level education in safeguards and related disciplines is an essential element in a layered strategy to rebuild the safeguards human resource capacity. NNSA launched two pilot programs in 2008 to develop university level courses and internships in association with James, Martin Center for Nonproliferation Studies (CNS) at the Monterey Institute of International Studies (MIIS) and Texas A&M University (TAMU). These pilot efforts involved 44 students in total andmore » were closely linked to hands-on internships at Los Alamos National Laboratory (LANL) and Lawrence Livermore National Laboratory (LLNL). The Safeguards and Nuclear Material Management pilot program was a collaboration between TAMU, LANL, and LLNL. The LANL-based coursework was shared with the students undertaking internships at LLNL via video teleconferencing. A weeklong hands-on exercise was also conducted at LANL. A second pilot effort, the International Nuclear Safeguards Policy and Information Analysis pilot program was implemented at MIIS in cooperation with LLNL. Speakers from MIIS, LLNL, and other U.S. national laboratories (LANL, BNL) delivered lectures for the audience of 16 students. The majority of students were senior classmen or new master's degree graduates from MIIS specializing in nonproliferation policy studies. The two pilots programs concluded with an NGSI Summer Student Symposium, held at LLNL, where 20 students participated in LLNL facility tours and poster sessions. The value of bringing together the students from the technical and policy pilots was notable and will factor into the planning for the continued refinement of the two programs in the coming years.« less

Automated System for Aneuploidy Detection in Sperm Final Report CRADA No. TC-1364-96: Phase I SBIR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wyrobek, A. J.; Dunlay, R. T.

This project was a relationship between Lawrence Livermore National Laboratory (LLNL) and Biological Detection, Inc. (now known as Cellomics, Inc.) It was funded as a Phase I SBIR from the National Institutes of Health (NIH) awarded to Cellomics, Inc. with a subcontract to LLNL.

Los Alamos and Lawrence Livermore National Laboratories Code-to-Code Comparison of Inter Lab Test Problem 1 for Asteroid Impact Hazard Mitigation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weaver, Robert P.; Miller, Paul; Howley, Kirsten

The NNSA Laboratories have entered into an interagency collaboration with the National Aeronautics and Space Administration (NASA) to explore strategies for prevention of Earth impacts by asteroids. Assessment of such strategies relies upon use of sophisticated multi-physics simulation codes. This document describes the task of verifying and cross-validating, between Lawrence Livermore National Laboratory (LLNL) and Los Alamos National Laboratory (LANL), modeling capabilities and methods to be employed as part of the NNSA-NASA collaboration. The approach has been to develop a set of test problems and then to compare and contrast results obtained by use of a suite of codes, includingmore » MCNP, RAGE, Mercury, Ares, and Spheral. This document provides a short description of the codes, an overview of the idealized test problems, and discussion of the results for deflection by kinetic impactors and stand-off nuclear explosions.« less

Integrating Statistical Mechanics with Experimental Data from the Rotational-Vibrational Spectrum of HCl into the Physical Chemistry Laboratory

ERIC Educational Resources Information Center

Findley, Bret R.; Mylon, Steven E.

2008-01-01

We introduce a computer exercise that bridges spectroscopy and thermodynamics using statistical mechanics and the experimental data taken from the commonly used laboratory exercise involving the rotational-vibrational spectrum of HCl. Based on the results from the analysis of their HCl spectrum, students calculate bulk thermodynamic properties…

The High-Foot Implosion Campaign on the National Ignition Facility

NASA Astrophysics Data System (ADS)

Hurricane, Omar

2013-10-01

The `High-Foot' platform manipulates the laser pulse-shape coming from the National Ignition Facility (NIF) laser to create an indirect drive 3-shock implosion that is significantly more robust against instability growth involving the ablator and also modestly reduces implosion convergence ratio. This tactic gives up on theoretical high-gain in an inertial confinement fusion implosion in order to obtain better control of the implosion and bring experimental performance in-line with calculated performance, yet keeps the absolute capsule performance relatively high. This approach is generally consistent with the philosophy laid out in a recent international workshop on the topic of ignition science on NIF [``Workshop on the Science of Fusion Ignition on NIF,'' Lawrence Livermore National Laboratory Report, LLNL-TR-570412 (2012). Op cit. V. Gocharov and O.A. Hurricane, ``Panel 3 Report: Implosion Hydrodynamics,'' LLNL-TR-562104 (2012)]. Side benefits our the High-Foot pulse-shape modification appear to be improvements in hohlraum behavior--less wall motion achieved through higher pressure He gas fill and improved inner cone laser beam propagation. Another consequence of the `High-Foot' is a higher fuel adiabat, so there is some relation to direct-drive experiments performed at the Laboratory for Laser Energetics (LLE). In this talk, we will cover the various experimental and theoretical motivations for the High-Foot drive as well as cover the experimental results that have come out of the High-Foot experimental campaign. Most notably, at the time of this writing record DT layer implosion performance with record low levels of inferred mix and excellent agreement with one-dimensional implosion models without the aid of mix models. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

Educational Revolution on the Reservation: A Working Model.

ERIC Educational Resources Information Center

Murphy, Pete

1993-01-01

Since 1986, Navajo Community College (NCC) and Lawrence Livermore National Laboratory (LLNL) have collaborated to improve science and technical education on the Navajo Reservation through equipment loans, faculty exchanges, summer student work at LLNL, scholarships for NCC students, summer workshops for elementary science teachers, and classroom…

Malignant melanoma slide review project: Patients from non-Kaiser hospitals in the San Francisco Bay Area. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reynolds, P.

This project was initiated, in response to concerns that the observed excess of malignant melanoma among employees of Lawrence Livermore National Laboratory (LLNL) might reflect the incidence of disease diagnostically different than that observed in the general population. LLNL sponsored a slide review project, inviting leading dermatopathology experts to independently evaluate pathology slides from LLNL employees diagnosed with melanoma and those from a matched sample of Bay Area melanoma patients who did not work at the LLNL. The study objectives were to: Identify all 1969--1984 newly diagnosed cases of malignant melanoma among LLNL employees resident in the San Francisco-Oakland Metropolitanmore » Statistical Area, and diagnosed at facilities other than Kaiser Permanente; identify a comparison series of melanoma cases also diagnosed between 1969--1984 in non-Kaiser facilities, and matched as closely as possible to the LLNL case series by gender, race, age at diagnosis, year of diagnosis, and hospital of diagnosis; obtain pathology slides for the identified (LLNL) case and (non-LLNL) comparison patients for review by the LLNL-invited panel of dermatopathology experts; and to compare the pathologic characteristics of the case and comparison melanoma patients, as recorded by the dermatopathology panel.« less

Demonstration of Laser Plasma X-Ray Source with X-Ray Collimator Final Report CRADA No. TC-1564-99

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lane, S. M.; Forber, R. A.

2017-09-28

This collaborative effort between the University of California, Lawrence Livermore National Laboratory (LLNL) and JMAR Research, Inc. (JRI), was to demonstrate that LLNL x-ray collimators can effectively increase the wafer throughput of JRI's laser based x-ray lithography systems. The technical objectives were expected to be achieved by completion of the following tasks, which are separated into two task lists by funding source. The organization (LLNL or JMAR) having primary responsibility is given parenthetically for each task.

Infrared Imaging Camera Final Report CRADA No. TC02061.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roos, E. V.; Nebeker, S.

This was a collaborative effort between the University of California, Lawrence Livermore National Laboratory (LLNL) and Cordin Company (Cordin) to enhance the U.S. ability to develop a commercial infrared camera capable of capturing high-resolution images in a l 00 nanoseconds (ns) time frame. The Department of Energy (DOE), under an Initiative for Proliferation Prevention (IPP) project, funded the Russian Federation Nuclear Center All-Russian Scientific Institute of Experimental Physics (RFNC-VNIIEF) in Sarov. VNIIEF was funded to develop a prototype commercial infrared (IR) framing camera and to deliver a prototype IR camera to LLNL. LLNL and Cordin were partners with VNIIEF onmore » this project. A prototype IR camera was delivered by VNIIEF to LLNL in December 2006. In June of 2007, LLNL and Cordin evaluated the camera and the test results revealed that the camera exceeded presently available commercial IR cameras. Cordin believes that the camera can be sold on the international market. The camera is currently being used as a scientific tool within Russian nuclear centers. This project was originally designated as a two year project. The project was not started on time due to changes in the IPP project funding conditions; the project funding was re-directed through the International Science and Technology Center (ISTC), which delayed the project start by over one year. The project was not completed on schedule due to changes within the Russian government export regulations. These changes were directed by Export Control regulations on the export of high technology items that can be used to develop military weapons. The IR camera was on the list that export controls required. The ISTC and Russian government, after negotiations, allowed the delivery of the camera to LLNL. There were no significant technical or business changes to the original project.« less

EPOS Multi-Scale Laboratory platform: a long-term reference tool for experimental Earth Sciences

NASA Astrophysics Data System (ADS)

Trippanera, Daniele; Tesei, Telemaco; Funiciello, Francesca; Sagnotti, Leonardo; Scarlato, Piergiorgio; Rosenau, Matthias; Elger, Kirsten; Ulbricht, Damian; Lange, Otto; Calignano, Elisa; Spiers, Chris; Drury, Martin; Willingshofer, Ernst; Winkler, Aldo

2017-04-01

will link the growing number of datasets to a centralized EPOS hub. Acknowledging the fact that we are dealing with a variety in levels of maturity regarding available data infrastructures within the different labs, we have set up an architecture that provides different scenarios for participation. Thus, research groups which do not have access to localized repositories and catalogues for sustainable storage of data and metadata can rely on shared services within the Multi-scale Laboratories community. As an example of the usage of data retrieved through the community, an experimentalist willing to decide which material is suitable for his experimental setup can get "virtual lab access" to retrieve information about material parameters with a minimum effort and then may decide to move in a specific laboratory equipped with the instruments needed. The currently participating and collaborating laboratories (Utrecht University, GFZ, Roma Tre University, INGV, NERC, CSIC-ICTJA, CNRS, LMU, UBI, ETH, CNR) warmly welcome everyone who is interested in participating at the development of this project.

Nutritional influences of overfeeding on experimental outcomes in laboratory mice: consequences for gut microbiota and other functional studies.

PubMed

Bischoff, Stephan C; Volynets, Valentina

2016-08-01

Data from literature suggests that laboratory mice are often overfed and malnourished. This might have several reasons, including: (i) we usually offer an ad libitum diet, which is not the natural way of feeding for a wild mouse; (ii) many commercial diets we use contain rather high amounts of carbohydrates, particularly of sugars, and low amounts of fat; and (iii) laboratory mice live in a warm and constricted environment in which energy expenditure is lower than in the wild. Such selective or global overfeeding in laboratory mice, which resembles the widespread overfeeding in humans, although it does not always result in overweight, likely affects a number of outcome variables analyzed in laboratory mice, such as microbiota composition and function, metabolic alterations, longevity, intestinal permeability and inflammation. Therefore, a careful selection of experimental diets and their way of administration, as well as detailed documentation, is mandatory in order to understand and compare scientific data obtained from different mouse experiments. Copyright © 2016. Published by Elsevier GmbH.

Experimental Investigations on the Surface-Driven Capillary Flow of Aqueous Microparticle Suspensions in the Microfluidic Laboratory-On Systems

NASA Astrophysics Data System (ADS)

Mukhopadhyay, Subhadeep

In this work, total 1592 individual leakage-free polymethylmethacrylate (PMMA) microfluidic devices as laboratory-on-a-chip systems are fabricated by maskless lithography, hot embossing lithography, and direct bonding technique. Total 1094 individual Audio Video Interleave Files as experimental outputs related to the surface-driven capillary flow have been recorded and analyzed. The influence of effective viscosity, effect of surface wettability, effect of channel aspect ratio, and effect of centrifugal force on the surface-driven microfluidic flow of aqueous microparticle suspensions have been successfully and individually investigated in these laboratory-on-a-chip systems. Also, 5 micron polystyrene particles have been separated from the aqueous microparticle suspensions in the microfluidic lab-on-a-chip systems of modified design with 98% separation efficiency, and 10 micron polystyrene particles have been separated with 100% separation efficiency. About the novelty of this work, the experimental investigations have been performed on the surface-driven microfluidic flow of aqueous microparticle suspensions with the investigations on the separation time in particle-size based separation mechanism to control these suspensions in the microfluidic lab-on-a-chip systems. This research work contains a total of 10,112 individual experimental outputs obtained using total 30 individual instruments by author’s own hands-on completely during more than three years continuously. Author has performed the experimental investigations on both the fluid statics and fluid dynamics to develop an automated fluid machine.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murray, Robert C.

Following the January 1980 earthquake that was felt at Lawrence Livermore National Laboratory (LLNL), a network of strong-motion accelerographs was installed at LLNL. Prior to the 1980 earthquake, there were no accelerographs installed. The ground motion from the 1980 earthquake was estimated from USGS instruments around the Laboratory to be between 0.2 – 0.3 g horizontal peak ground acceleration. These instruments were located at the Veterans Hospital, 5 miles southwest of LLNL, and in San Ramon, about 12 miles west of LLNL. In 2011, the Department of Energy (DOE) requested to know the status of our seismic instruments. We conductedmore » a survey of our instrumentation systems and responded to DOE in a letter. During this survey, it was found that the recorders in Buildings 111 and 332 were not operational. The instruments on Nova had been removed, and only three of the 10 NIF instruments installed in 2005 were operational (two were damaged and five had been removed from operation at the request of the program). After the survey, it was clear that the site seismic instrumentation had degraded substantially and would benefit from an overhaul and more attention to ongoing maintenance. LLNL management decided to update the LLNL seismic instrumentation system. The updated system is documented in this report.« less

2004 Environmental Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Althouse, P E; Bertoldo, N A; Brown, R A

2005-09-28

The Lawrence Livermore National Laboratory (LLNL) annual Environmental Report, prepared for the Department of Energy (DOE) and made available to the public, presents summary environmental data that characterizes site environmental management performance, summarizes environmental occurrences and responses reported during the calendar year, confirms compliance with environmental standards and requirements, and highlights significant programs and efforts. By explaining the results of effluent and environmental monitoring, mentioning environmental performance indicators and performance measure programs, and assessing the impact of Laboratory operations on the environment and the public, the report also demonstrates LLNL's continuing commitment to minimize any potentially adverse impact of itsmore » operations. The combination of environmental and effluent monitoring, source characterization, and dose assessment showed that radiological doses to the public caused by LLNL operations in 2004 were less than 0.26% of regulatory standards and more than 11,000 times smaller than dose from natural background. Analytical results and evaluations generally showed continuing low levels of most contaminants; remediation efforts further reduced the concentrations of contaminants of concern in groundwater and soil vapor. In addition, LLNL's extensive environmental compliance activities related to water, air, endangered species, waste, wastewater, and waste reduction controlled or reduced LLNL's effects on the environment. LLNL's environmental program clearly demonstrates a commitment to protecting the environment from operational impacts.« less

Calibration of the Lawrence Livermore National Laboratory Passive-Active Neutron Drum Shuffler for Measurement of Highly Enriched Uranium in Oxides within DOE-STD-3013-2000 Containers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mount, M E; O'Connell, W J

2005-06-03

Lawrence Livermore National Laboratory (LLNL) uses the LLNL passive-active neutron drum (PAN) shuffler (Canberra Model JCC-92) for accountability measurement of highly enriched uranium (HEU) oxide and HEU in mixed uranium-plutonium (U-Pu) oxide. In June 2002, at the 43rd Annual Meeting of the Institute of Nuclear Material Management, LLNL reported on an extensive effort to calibrate this shuffler, based on standards measurements and extensive simulations, for HEU oxides and mixed U-Pu oxides in thin-walled primary and secondary containers. In August 2002, LLNL began to also use DOE-STD-3013-2000 containers for HEU oxide and mixed U-Pu oxide. These DOE-STD-3013-2000 containers are comprised ofmore » a stainless steel convenience can enclosed in welded stainless steel primary and secondary containers. Compared to the double thin-walled containers, the DOE-STD-3013-2000 containers have substantially thicker walls, and the density of materials in these containers was found to extend over a greater range (1.35 g/cm{sup 3} to 4.62 g/cm{sup 3}) than foreseen for the double thin-walled containers. Further, the DOE-STD-3013-2000 Standard allows for oxides containing at least 30 wt% Pu plus U whereas the calibration algorithms for thin-walled containers were derived for virtually pure HEU or mixed U-Pu oxides. An initial series of Monte Carlo simulations of the PAN shuffler response to given quantities of HEU oxide and mixed U-Pu oxide in DOE-STD-3013-2000 containers was generated and compared with the response predicted by the calibration algorithms for thin-walled containers. Results showed a decrease on the order of 10% in the count rate, and hence a decrease in the calculated U mass for measured unknowns, with some varying trends versus U mass. Therefore a decision was made to develop a calibration algorithm for the PAN shuffler unique to the DOE-STD-3013-2000 container. This paper describes that effort and selected unknown item measurement results.« less

Comparison of Laboratory Experimental Data to XBeach Numerical Model Output

NASA Astrophysics Data System (ADS)

Demirci, Ebru; Baykal, Cuneyt; Guler, Isikhan; Sogut, Erdinc

2016-04-01

generating data sets for testing and validation of sediment transport relationships for sand transport in the presence of waves and currents. In these series, there is no structure in the basin. The second and third series of experiments were designed to generate data sets for development of tombolos in the lee of detached 4m-long rubble mound breakwater that is 4 m from the initial shoreline. The fourth series of experiments are conducted to investigate tombolo development in the lee of a 4m-long T-head groin with the head section in the same location of the second and the third tests. The fifth series of experiments are used to investigate tombolo development in the lee of a 3-m-long rubble-mound breakwater positioned 1.5 m offshore of the initial shoreline. In this study, the data collected from the above mentioned five experiments are used to compare the results of the experimental data with XBeach numerical model results, both for the "no-structure" and "with-structure" cases regarding to sediment transport relationships in the presence of only waves and currents as well as the shoreline changes together with the detached breakwater and the T-groin. The main purpose is to investigate the similarities and differences between the laboratory experimental data behavior with XBeach numerical model outputs for these five cases. References: Baykal, C., Sogut, E., Ergin, A., Guler, I., Ozyurt, G.T., Guler, G., and Dogan, G.G. (2015). Modelling Long Term Morphological Changes with XBeach: Case Study of Kızılırmak River Mouth, Turkey, European Geosciences Union, General Assembly 2015, Vienna, Austria, 12-17 April 2015. Gravens, M.B. and Wang, P. (2007). "Data report: Laboratory testing of longshore sand transport by waves and currents; morphology change behind headland structures." Technical Report, ERDC/CHL TR-07-8, Coastal and Hydraulics Laboratory, US Army Engineer Research and Development Center, Vicksburg, MS. Roelvink, D., Reniers, A., van Dongeren, A., van Thiel de

The Automation of the Transonic Experimental Facility (TEF) and the Aerodynamic Experimental Facility (AEF)

DTIC Science & Technology

2015-10-01

ARL-TR-7506 ● OCT 2015 US Army Research Laboratory The Automation of the Transonic Experimental Facility (TEF) and the...Laboratory The Automation of the Transonic Experimental Facility (TEF) and the Aerodynamic Experimental Facility (AEF) by Charith R Ranawake Weapons...To) 05/2015–08/2015 4. TITLE AND SUBTITLE The Automation of the Transonic Experimental Facility (TEF) and the Aerodynamic Experimental Facility

Experimental fusion of different versions of the total laboratory automation system and improvement of laboratory turnaround time.

PubMed

Chung, Hee-Jung; Song, Yoon Kyung; Hwang, Sang-Hyun; Lee, Do Hoon; Sugiura, Tetsuro

2018-02-25

Use of total laboratory automation (TLA) system has expanded to microbiology and hemostasis and upgraded to second and third generations. We herein report the first successful upgrades and fusion of different versions of the TLA system, thus improving laboratory turnaround time (TAT). A 21-day schedule was planned from the time of pre-meeting to installation and clinical sample application. We analyzed the monthly TAT in each menu, distribution of the "out of range for acceptable TAT" samples, and "prolonged time out of acceptable TAT," before and after the upgrade and fusion. We installed and customized hardware, middleware, and software. The one-way CliniLog 2.0 version track, 50.0-m long, was changed to a 23.2-m long one-way 2.0 version and an 18.7-m long two-way 4.0 version. The monthly TAT in the outpatient samples, before and after upgrading the TLA system, were uniformly satisfactory in the chemistry and viral marker menus. However, in the tumor marker menu, the target TAT (98.0% of samples ≤60 minutes) was not satisfied during the familiarization period. There was no significant difference in the proportion of "out of acceptable TAT" samples, before and after the TLA system upgrades (7.4‰ and 8.5‰). However, the mean "prolonged time out of acceptable TAT" in the chemistry samples was significantly shortened to 17.4 (±24.0) minutes after the fusion, from 34.5 (±43.4) minutes. Despite experimental challenges, a fusion of the TLA system shortened the "prolonged time out of acceptable TAT," indicating a distribution change in overall TAT. © 2018 Wiley Periodicals, Inc.

Good Laboratory Practice. Part 3. Implementing Good Laboratory Practice in the Analytical Lab

ERIC Educational Resources Information Center

Wedlich, Richard C.; Pires, Amanda; Fazzino, Lisa; Fransen, Joseph M.

2013-01-01

Laboratories submitting experimental results to the Food and Drug Administration (FDA) or the Environmental Protection Agency (EPA) in support of Good Laboratory Practice (GLP) nonclinical laboratory studies must conduct such work in compliance with the GLP regulations. To consistently meet these requirements, lab managers employ a "divide…

Making of the underground scientific experimental programme at the Meuse/Haute-Marne underground research laboratory, North Eastern France

NASA Astrophysics Data System (ADS)

Delay, Jacques; Vinsot, Agnès; Krieguer, Jean-Marie; Rebours, Hervé; Armand, Gilles

In November 1999 Andra began building an Underground Research Laboratory (URL) on the border of the Meuse and Haute-Marne departments in eastern France. The research activities of the URL are dedicated to study the feasibility of reversible, deep geological disposal of high-activity, long-lived radioactive wastes in an argillaceous host rock. The Laboratory consists of two shafts, an experimental drift at 445 m depth and a set of technical and experimental drifts at the main level at 490 m depth. The main objective of the research is to characterize the confining properties of the argillaceous rock through in situ hydrogeological tests, chemical measurements and diffusion experiments. In order to achieve this goal, a fundamental understanding of the geoscientific properties and processes that govern geological isolation in clay-rich rocks has been acquired. This understanding includes both the host rocks at the laboratory site and the regional geological context. After establishing the geological conditions, the underground research programme had to demonstrate that the construction and operation of a geological disposal will not introduce pathways for waste migration. Thus, the construction of the laboratory itself serves a research purpose through the monitoring of excavation effects and the optimization of construction technology. These studies are primarily geomechanical in nature, though chemical and hydrogeological coupling also have important roles. In order to achieve the scientific objectives of this project in the underground drifts, a specific methodology has been applied for carrying out the experimental programme conducted concurrently with the construction of the shafts and drifts. This methodology includes technological as well as organizational aspects and a systematic use of feedback from other laboratories abroad and every scientific zone of the URL already installed. This methodology was first applied to set up a multi-purpose experimental area

Energy and technology review

NASA Astrophysics Data System (ADS)

Johnson, K. C.

1991-04-01

This issue of Energy and Technology Review discusses the various educational programs in which Lawrence Livermore National Laboratory (LLNL) participates or sponsors. LLNL has a long history of fostering educational programs for students from kindergarten through graduate school. A goal is to enhance the teaching of science, mathematics, and technology and thereby assist educational institutions to increase the pool of scientists, engineers, and technicians. LLNL programs described include: (1) contributions to the improvement of U.S. science education; (2) the LESSON program; (3) collaborations with Bay Area Science and Technology Education; (4) project HOPES; (5) lasers and fusion energy education; (6) a curriculum on global climate change; (7) computer and technology instruction at LLNL's Science Education Center; (8) the National Education Supercomputer Program; (9) project STAR; (10) the American Indian Program; (11) LLNL programs with historically Black colleges and Universities; (12) the Undergraduate Summer Institute on Contemporary Topics in Applied Science; (13) the National Physical Science Consortium: A Fellowship Program for Minorities and Women; (14) LLNL's participation with AWU; (15) the apprenticeship programs at LLNL; and (16) the future of LLNL's educational programs. An appendix lists all of LLNL's educational programs and activities. Contacts and their respective telephone numbers are given for all these programs and activities.

Criteria evaluation for cleanliness testing phase 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meltzer, Michael; Koester, Carolyn; Stefanni, Chris

1999-02-04

The Boeing Company (Boeing) contracted with Lawrence Livermore National Laboratory (LLNL) to develop criteria for evaluating the efficacy of its parts cleaning processes. In particular, LLNL and Boeing are attempting to identify levels of contamination that lead to parts failures. Sufficient contamination to cause impairment of anodizing, alodining, painting, or welding operations is considered a "part failure." In the "Phase 0" part of the project that was recently completed, preliminary analyses of aluminum substrates were performed as a first step in determining suitable cleanliness criteria for actual Boeing parts made from this material. A wide spread of contamination levels wasmore » specified for the Phase 0 test coupons, in the hopes of finding a range in which an appropriate cleanliness specification might lie. It was planned that, based on the results of the Phase 0 testing, further more detailed analyses ("Phase 1 testing") would be performed in order to more accurately identify the most appropriate criteria. For the Phase 0 testing, Boeing supplied LLNL with 3" x 6" and 3" x 10" aluminum test panels which LLNL contaminated with measured amounts of typical hydrocarbon substances encountered in Boeing' s fabrication operations. The panels were then subjected by Boeing to normal cleaning procedures, after which they went through one of the following sets of operations: l anodizing and primer painting . alodining (chromating) and primer painting l welding The coatings or welds were then examined by both Boeing and LLNL to determine whether any of the operations were impaired, and whether there was a correlation between contamination level and damage to the parts. The experimental approach and results are described in detail.« less

LLNL demonstration of liquid gun propellant destruction in a 0.1 gallon per minute scale reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cena, R.J.; Thorsness, C.B.; Coburn, T.T.

1994-06-01

The Lawrence Livermore National Laboratory (LLNL) has built and operated a pilot plant for processing oil shale using recirculating hot solids. This pilot plant, was adapted in 1993 to demonstrate the feasibility of decomposing a liquid gun propellant (LGP), LP XM46, a mixture of 76% HAN (NH{sub 3}OHNO{sub 3}) and 24% TEAN (HOCH{sub 2}CH{sub 2}){sub 3} NHNO{sub 3} diluted 1:3 in water. In the Livermore process, the LPG is thermally treated in a moving packed bed of ceramic spheres, where TEAN and HAN decompose, forming a suite of gases including: methane, carbon monoxide, oxygen, nitrogen oxides, ammonia and molecular nitrogen.more » The ceramic spheres are circulated and heated, providing the energy required for thermal decomposition. The authors performed an extended one day (8 hour) test of the solids recirculation system, with continuous injection of approximately 0.1 gal/min of LGP, diluted 1:3 in water, for a period of eight hours. The apparatus operated smoothly over the course of the eight hour run during which 144 kg of solution was processed, containing 36 kg of LGP. Continuous on-line gas analysis was invaluable in tracking the progress of the experiment and quantifying the decomposition products. The reactor was operated in two modes, a {open_quotes}Pyrolysis{close_quotes} mode, where decomposition products were removed from the moving bed reactor exit, passing through condensers to a flare, and in a {open_quotes}Combustion{close_quotes} mode, where the products were oxidized in air lift pipe prior to exiting the system. In the {open_quotes}Pyrolysis{close_quotes} mode, driver gases were recycled producing a small, concentrated stream of decomposition products. In the {open_quotes}Combustion mode{close_quotes}, the driver gases were not recycled, resulting in 40 times higher gas flow rates and correspondingly lower concentrations of nitrogen bearing gases.« less

Applying Science and Technology to Combat WMD Terrorism

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wuest, C R; Werne, R W; Colston, B W

2006-05-04

Lawrence Livermore National Laboratory (LLNL) is developing and fielding advanced strategies that dramatically improve the nation's capabilities to prevent, prepare for, detect, and respond to terrorist use of chemical, biological, radiological, nuclear, and explosive (CBRNE) weapons. The science, technology, and integrated systems we provide are informed by and developed with key partners and end users. LLNL's long-standing role as one of the two principle U.S. nuclear weapons design laboratories has led to significant resident expertise for health effects of exposure to radiation, radiation detection technologies, characterization of radioisotopes, and assessment and response capabilities for terrorist nuclear weapons use. This papermore » provides brief overviews of a number of technologies developed at LLNL that are being used to address national security needs to confront the growing threats of CBRNE terrorism.« less

Applying science and technology to combat WMD terrorism

NASA Astrophysics Data System (ADS)

Wuest, Craig R.; Werne, Roger W.; Colston, Billy W.; Hartmann-Siantar, Christine L.

2006-05-01

Lawrence Livermore National Laboratory (LLNL) is developing and fielding advanced strategies that dramatically improve the nation's capabilities to prevent, prepare for, detect, and respond to terrorist use of chemical, biological, radiological, nuclear, and explosive (CBRNE) weapons. The science, technology, and integrated systems we provide are informed by and developed with key partners and end users. LLNL's long-standing role as one of the two principle U.S. nuclear weapons design laboratories has led to significant resident expertise for health effects of exposure to radiation, radiation detection technologies, characterization of radioisotopes, and assessment and response capabilities for terrorist nuclear weapons use. This paper provides brief overviews of a number of technologies developed at LLNL that are being used to address national security needs to confront the growing threats of CBRNE terrorism.

Wundt's laboratory at Leipzig in 1891.

PubMed

Nicolas, S; Ferrand, L

1999-08-01

This article describes Wundt's laboratory at Leipzig in 1891 as viewed by a Belgian psychologist, J.J. Van Biervliet (1859-1945). Although few French-speaking psychologists worked in Wundt's laboratory, several of those who did reports wrote on how students were trained there. Van Biervliet decided to visit Wundt's laboratory at Leipzig in order to strengthen the foundation of his own laboratory at the University of Ghent and to become familiar with Wundt's experimental techniques. A translation of J.J. Van Biervliet's (1892) article "Experimental Psychology. Wundt's Institute at Leipzig" is presented here as one of the first and most complete articles in French describing the functioning of Wundt's laboratory.

Site Safety Plan for Lawrence Livermore National Laboratory CERCLA investigations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bainer, R.; Duarte, J.

1993-07-01

The safety policy of LLNL is to take every reasonable precaution in the performance of work to protect the environment and the health and safety of employees and the public, and to prevent property damage. With respect to hazardous agents, this protection is provided by limiting human exposures, releases to the environment, and contamination of property to levels that are as low as reasonably achievable (ALARA). It is the intent of this Plan to supply the broad outline for completing environmental investigations within ALARA guidelines. It may not be possible to determine actual working conditions in advance of the work;more » therefore, planning must allow the opportunity to provide a range of protection based upon actual working conditions. Requirements will be the least restrictive possible for a given set of circumstances, such that work can be completed in an efficient and timely fashion. Due to the relatively large size of the LLNL Site and the different types of activities underway, site-specific Operational Safety Procedures (OSPs) will be prepared to supplement activities not covered by this Plan. These site-specific OSPs provide the detailed information for each specific activity and act as an addendum to this Plan, which provides the general plan for LLNL Main Site operation.« less

Gas Atomization Equipment Statement of Work and Specification for Engineering design, Fabrication, Testing, and Installation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boutaleb, T.; Pluschkell, T. P.

The Gas Atomization Equipment will be used to fabricate metallic powder suitable for Powder Bed Fusion additive Manufacturing material to support Lawrence Livermore National Laboratory (LLNL) research and development. The project will modernize our capabilities to develop spherical reactive, refractory, and radioactive powders in the 10-75 μm diameter size range at LLNL.

Development of an Interdisciplinary Experimental Series for the Laboratory Courses of Cell and Molecular Biology and Advance Inorganic Chemistry

ERIC Educational Resources Information Center

Smith, Montserrat Rabago; McAllister, Robert; Newkirk, Kiera; Basing, Alexander; Wang, Lihua

2012-01-01

An interdisciplinary approach to education has become more important in the development of science and technology, which requires universities to have graduates with broad knowledge and skills and to apply these skills in solving real-world problems. An interdisciplinary experimental series has been developed for the laboratories in cell and…

Wiki Laboratory Notebooks: Supporting Student Learning in Collaborative Inquiry-Based Laboratory Experiments

NASA Astrophysics Data System (ADS)

Lawrie, Gwendolyn Angela; Grøndahl, Lisbeth; Boman, Simon; Andrews, Trish

2016-06-01

Recent examples of high-impact teaching practices in the undergraduate chemistry laboratory that include course-based undergraduate research experiences and inquiry-based experiments require new approaches to assessing individual student learning outcomes. Instructors require tools and strategies that can provide them with insight into individual student contributions to collaborative group/teamwork throughout the processes of experimental design, data analysis, display and communication of their outcomes in relation to their research question(s). Traditional assessments in the form of laboratory notebooks or experimental reports provide limited insight into the processes of collaborative inquiry-based activities. A wiki environment offers a collaborative domain that can potentially support collaborative laboratory processes and scientific record keeping. In this study, the effectiveness of the wiki in supporting laboratory learning and assessment has been evaluated through analysis of the content and histories for three consenting, participating groups of students. The conversational framework has been applied to map the relationships between the instructor, tutor, students and laboratory activities. Analytics that have been applied to the wiki platform include: character counts, page views, edits, timelines and the extent and nature of the contribution by each student to the wiki. Student perceptions of both the role and the impact of the wiki on their experiences and processes have also been collected. Evidence has emerged from this study that the wiki environment has enhanced co-construction of understanding of both the experimental process and subsequent communication of outcomes and data. A number of features are identified to support success in the use of the wiki platform for laboratory notebooks.

Development of Plastic Substrate Technology for Active Matrix Liquid Crystal Displays Final Report CRADA No. TC-761-93

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carey, P.; Kamath, H.

Raychem Corporation (RYC) and the Lawrence Livermore National Laboratory (LLNL) conducted a development program with the goal to make rugged, low-cost., high-resolution flat panel displays based on RYC's proprietary Nematic Curvilinear Aligned Phase (NCAP) liquid crystal and LLNL's patented processes for the formation and doping of polycrystalline silicon on low-temperature, flexible, plastic substrates.

LINC Modeling of August 19, 2004 Queen City Barrel Company Fire In Cincinnati, OH

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dillon, M B; Nasstrom, J S; Baskett, R L

This report details the information received, assumptions made, actions taken, and products delivered by the Lawrence Livermore National Laboratory (LLNL) during the August 19, 2004 fire at the Queen City Barrel Company (QCB) in Cincinnati, OH. During the course of the event, LLNL provided four sets of plume model products to various Cincinnati emergency response organizations.

The Next Linear Collider Program

Science.gov Websites

Navbar Other Address Books: Laboratory Phone/Email Web Directory SLAC SLAC Phonebook Entire SLAC Web FNAL Telephone Directory Fermilab Search LLNL Phone Book LLNL Web Servers LBNL Directory Services Web Search: A-Z Index KEK E-mail Database Research Projects NLC Website Search: Entire SLAC Web | Help

Study of laser-generated debris free x-ray sources produced in a high-density linear Ar, Kr, Xe, Kr/Ar and Xe/Kr/Ar mixtures gas jets by 2 ω, sub-ps LLNL Titan laser

NASA Astrophysics Data System (ADS)

Kantsyrev, V. L.; Schultz, K. A.; Shlyaptseva, V. V.; Safronova, A. S.; Cooper, M. C.; Shrestha, I. K.; Petkov, E. E.; Stafford, A.; Moschella, J. J.; Schmidt-Petersen, M. T.; Butcher, C. J.; Kemp, G. E.; Andrews, S. D.; Fournier, K. B.

2016-10-01

The study of laser-generated debris-free x-ray sources in an underdense plasma produced in a high-density linear gas-puff jet was carried out at the LLNL Titan laser (2 ω, 45 J, sub-ps) with an intensity in the 10 um focal spot of 7 x 1019 W/cm2. A linear nozzle with a fast valve was used for the generation of a clusters/gas jet. X-ray diagnostics for the spectral region of 0.7 - 9 keV include: two spectrometers and pinhole cameras, and 3 groups of fast filtered detectors. Electron beams were measured with the EPPS magnetic spectrometer (>1 MeV) and Faraday cups (>72 keV). Spectralon/spectrometer devices were also used to measure absorption of laser radiation in the jets. New results were obtained on: anisotropic generation of x-rays (laser to x-ray conversion coefficient was >1%) and characteristics of laser-generated electron beams; evolution of x-ray generation with the location of the laser focus in a cluster-gas jet, and observations of a strong x-ray flash in some focusing regimes. Non-LTE kinetic modeling was used to estimate plasma parameters. UNR work supported by the DTRA Basic Research Award # HDTRA1-13-1-0033. Work at LLNL was performed under the auspices of the U.S. DOE by LLNL under Contract DE-AC52-07NA27344.

The Subsurface Flow and Transport Laboratory: A New Department of Energy User's Facility for Intermediate-Scale Experimentation

NASA Astrophysics Data System (ADS)

Wietsma, T. W.; Oostrom, M.; Foster, N. S.

2003-12-01

Intermediate-scale experiments (ISEs) for flow and transport are a valuable tool for simulating subsurface features and conditions encountered in the field at government and private sites. ISEs offer the ability to study, under controlled laboratory conditions, complicated processes characteristic of mixed wastes and heterogeneous subsurface environments, in multiple dimensions and at different scales. ISEs may, therefore, result in major cost savings if employed prior to field studies. A distinct advantage of ISEs is that researchers can design physical and/or chemical heterogeneities in the porous media matrix that better approximate natural field conditions and therefore address research questions that contain the additional complexity of processes often encountered in the natural environment. A new Subsurface Flow and Transport Laboratory (SFTL) has been developed for ISE users in the Environmental Spectroscopy & Biogeochemistry Facility in the Environmental Molecular Sciences Laboratory (EMSL) at Pacific Northwest National Laboratory (PNNL). The SFTL offers a variety of columns and flow cells, a new state-of-the-art dual-energy gamma system, a fully automated saturation-pressure apparatus, and analytical equipment for sample processing. The new facility, including qualified staff, is available for scientists interested in collaboration on conducting high-quality flow and transport experiments, including contaminant remediation. Close linkages exist between the SFTL and numerical modelers to aid in experimental design and interpretation. This presentation will discuss the facility and outline the procedures required to submit a proposal to use this unique facility for research purposes. The W. R. Wiley Environmental Molecular Sciences Laboratory, a national scientific user facility, is sponsored by the U.S. Department of Energy's Office of Biological and Environmental Research and located at Pacific Northwest National Laboratory.

Environmental Report 2007

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mathews, S; Gallegos, G; Berg, L L

2008-09-24

The purposes of the 'Lawrence Livermore National Laboratory Environmental Report 2007' are to record Lawrence Livermore National Laboratory's (LLNL's) compliance with environmental standards and requirements, describe LLNL's environmental protection and remediation programs, and present the results of environmental monitoring at the two LLNL sites--the Livermore site and Site 300. The report is prepared for the U.S. Department of Energy (DOE) by LLNL's Environmental Protection Department. Submittal of the report satisfies requirements under DOE Order 231.1A, Environmental Safety and Health Reporting, and DOE Order 5400.5, Radiation Protection of the Public and Environment. The report is distributed electronically and is available atmore » https://saer.lln.gov/, the website for the LLNL annual environmental report. Previous LLNL annual environmental reports beginning in 1994 are also on the website. Some references in the electronic report text are underlined, which indicates that they are clickable links. Clicking on one of these links will open the related document, data workbook, or website that it refers to. The report begins with an executive summary, which provides the purpose of the report and an overview of LLNL's compliance and monitoring results. The first three chapters provide background information: Chapter 1 is an overview of the location, meteorology, and hydrogeology of the two LLNL sites; Chapter 2 is a summary of LLNL's compliance with environmental regulations; and Chapter 3 is a description of LLNL's environmental programs with an emphasis on the Environmental Management System including pollution prevention. The majority of the report covers LLNL's environmental monitoring programs and monitoring data for 2007: effluent and ambient air (Chapter 4); waters, including wastewater, storm water runoff, surface water, rain, and groundwater (Chapter 5); and terrestrial, including soil, sediment, vegetation, foodstuff, ambient radiation, and special

Developing a new experimental system for an undergraduate laboratory exercise to teach theories of visuomotor learning.

PubMed

Kasuga, Shoko; Ushiba, Junichi

2014-01-01

Humans have a flexible motor ability to adapt their movements to changes in the internal/external environment. For example, using arm-reaching tasks, a number of studies experimentally showed that participants adapt to a novel visuomotor environment. These results helped develop computational models of motor learning implemented in the central nervous system. Despite the importance of such experimental paradigms for exploring the mechanisms of motor learning, because of the cost and preparation time, most students are unable to participate in such experiments. Therefore, in the current study, to help students better understand motor learning theories, we developed a simple finger-reaching experimental system using commonly used laptop PC components with an open-source programming language (Processing Motor Learning Toolkit: PMLT). We found that compared to a commercially available robotic arm-reaching device, our PMLT accomplished similar learning goals (difference in the error reduction between the devices, P = 0.10). In addition, consistent with previous reports from visuomotor learning studies, the participants showed after-effects indicating an adaptation of the motor learning system. The results suggest that PMLT can serve as a new experimental system for an undergraduate laboratory exercise of motor learning theories with minimal time and cost for instructors.

Purple Computational Environment With Mappings to ACE Requirements for the General Availability User Environment Capabilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barney, B; Shuler, J

2006-08-21

Purple is an Advanced Simulation and Computing (ASC) funded massively parallel supercomputer located at Lawrence Livermore National Laboratory (LLNL). The Purple Computational Environment documents the capabilities and the environment provided for the FY06 LLNL Level 1 General Availability Milestone. This document describes specific capabilities, tools, and procedures to support both local and remote users. The model is focused on the needs of the ASC user working in the secure computing environments at Los Alamos National Laboratory, Lawrence Livermore National Laboratory, and Sandia National Laboratories, but also documents needs of the LLNL and Alliance users working in the unclassified environment. Additionally,more » the Purple Computational Environment maps the provided capabilities to the Trilab ASC Computing Environment (ACE) Version 8.0 requirements. The ACE requirements reflect the high performance computing requirements for the General Availability user environment capabilities of the ASC community. Appendix A lists these requirements and includes a description of ACE requirements met and those requirements that are not met for each section of this document. The Purple Computing Environment, along with the ACE mappings, has been issued and reviewed throughout the Tri-lab community.« less

Attenuation and Transport Mechanisms of Depleted Uranium in Groundwater at Lawrence Livermore National Laboratory Site 300

NASA Astrophysics Data System (ADS)

Danny, K. R.; Taffet, M. J.; Brusseau, M. L. L.; Chorover, J.

2015-12-01

Lawrence Livermore National Laboratory (LLNL) Site 300 was established in 1955 to support weapons research and development. Depleted uranium was used as a proxy for fissile uranium-235 (235U) in open-air explosives tests conducted at Building 812. As a result, oxidized depleted uranium was deposited on the ground, eventually migrating to the underlying sandstone aquifer. Uranium (U) groundwater concentrations exceed the California and Federal Maximum Contaminant Level of 20 pCi L-1 (30 ug L-1). However, the groundwater plume appears to attenuate within 60 m of the source, beyond which no depleted U is detected. This study will determine the relative contribution of physical (e.g. dilution), chemical (e.g. surface adsorption, mineral precipitation), and biological (e.g. biotransformation) processes that contribute to the apparent attenuation of U, which exists as uranyl (UO22+) complexes, at the site. Methods of investigation include evaluating 15 yr of hydrogeologic and chemical data, creating a site conceptual model, and applying equilibrium (e.g. aqueous species complexation, mineral saturation indices) and reactive transport models using Geochemist's WorkbenchTM. Reactive transport results are constrained by direct field observations, including U major ion, and dissolved O2 concentrations, pH, and others, under varying chemical and hydraulic conditions. Aqueous speciation calculations indicate that U primarily exists as anionic CaUO2(CO3)32- or neutral Ca2UO2(CO3)30 species. Additionally, nucleation and growth of Ca/Mg uranyl carbonate solids are predicted to affect attenuation. Initial reactive transport results suggest surface adsorption (e.g. ion exchange, surface complexation) to layer silicate clays is limited under the aqueous geochemical conditions of the site. Current and future work includes XRD analysis of aquifer solids to constrain iron and aluminum (oxy)hydroxides, and coupling advective-dispersive transport with the chemical and physical processes

LLNL: Science in the National Interest

ScienceCinema

George Miller

2017-12-09

This is Lawrence Livermore National Laboratory. located in the Livermore Valley about 50 miles east of San Francisco, the Lab is where the nations topmost science, engineering and technology come together. National security, counter-terrorism, medical technologies, energy, climate change our researchers are working to develop solutions to these challenges. For more than 50 years, we have been keeping America strong.

Finite element analysis of constrained total Condylar Knee Prosthesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-07-13

Exactech, Inc., is a prosthetic joint manufacturer based in Gainesville, FL. The company set the goal of developing a highly effective prosthetic articulation, based on scientific principles, not trial and error. They developed an evolutionary design for a total knee arthroplasty system that promised improved performance. They performed static load tests in the laboratory with similar previous designs, but dynamic laboratory testing was both difficult to perform and prohibitively expensive for a small business to undertake. Laboratory testing also cannot measure stress levels in the interior of the prosthesis where failures are known to initiate. To fully optimize their designsmore » for knee arthroplasty revisions, they needed range-of-motion stress/strain data at interior as well as exterior locations within the prosthesis. LLNL developed computer software (especially NIKE3D) specifically designed to perform stress/strain computations (finite element analysis) for complex geometries in large displacement/large deformation conditions. Additionally, LLNL had developed a high fidelity knee model for other analytical purposes. The analysis desired by Exactech could readily be performed using NIKE3D and a modified version of the high fidelity knee that contained the geometry of the condylar knee components. The LLNL high fidelity knee model was a finite element computer model which would not be transferred to Exactech during the course of this CRADA effort. The previously performed laboratory studies by Exactech were beneficial to LLNL in verifying the analytical capabilities of NIKE3D for human anatomical modeling. This, in turn, gave LLNL further entree to perform work-for-others in the prosthetics field. There were two purposes to the CRADA (1) To modify the LLNL High Fidelity Knee Model to accept the geometry of the Exactech Total Knee; and (2) To perform parametric studies of the possible design options in appropriate ranges of motion so that an optimum design

Laser program annual report 1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hendricks, C.D.; Rufer, M.L.; Murphy, P.W.

1984-06-01

In the 1983 Laser Program Annual Report we present the accomplishments and unclassified activities of the Laser Program at Lawrence Livermore National laboratory (LLNL) for the year 1983. It should be noted that the report, of necessity, is a summary, and more detailed expositions of the research can be found in the many publications and reports authored by staff members in the Laser Program. The purpose of this report is to present our work in a brief form, but with sufficient depth to provide an overview of the analytical and experimental aspects of the LLNL Inertial-Confinement Fusion (ICF) Program. Themore » format of this report is basically the same as that of previous years. Section 1 is an overview and highlights the important accomplishments and directions of the Program. Sections 2 through 7 provide the detailed information on the various major parts of the Program: Laser Systems and Operations, Target Design, Target Fabrication, Fusion Experiments, Laser Research and Development, and Energy Applications.« less

Initial Experimental Results of a Laboratory Mini-Magnetosphere for Astronaut Protection

NASA Astrophysics Data System (ADS)

Bamford, R. A.; Bingham, R.; Gibson, K.; Thornton, A.; Bradford, J.; Hapgood, M.; Gargate, L.; Silva, L.; Norberg, C.; Todd, T.; Wilson, H.; Stamper, R.

2007-12-01

Radiation is a major scientific and technological challenge for manned missions to Mars. With an interplanetary flight time of months to years there is a high probability of Solar Energetic Particle events during the flight. Radiation damage to human tissue could result in acute sickness or death of the occupants of an unprotected spacecraft. Thus there is much interest in techniques to mitigate the effects of these events and of the exposure to cosmic rays. The experimental and modelling work presented here concerns one of several innovative "Active Shield" solutions being proposed [1]. The idea of generating an artificial magnetosphere to recreate the protective shield of the Earth's magnetic field for space craft travelling to the Moon or Mars was considered seriously in the 1960's during the Apollo era. With most of the space agencies around the world setting their sights returning to the Moon and then on to Mars, the idea of some sort of active field solution is experiencing a resurgence. Results from the laboratory experiment to determine the effectiveness of a mini-magnetosphere barrier to be able to expel a flowing energetic "solar wind" plasma will be presented. This is compared to a 3D hybrid simulation code that has been successfully compared to other astrophysical situations e.g. AMPTE artificial comet releases [2]. The experiment and modelling comparisons will demonstrate the scalability between the laboratory and astrophysical scale. [1] Adams, J.H. et al., "Revolutionary Concepts of Radiation Shielding for Human Exploration of Space", NASA/TM- 2005-213688, March 2005. [2] Gargate, L.; Bingham, R.; Fonseca, R. A.; Silva, L. O., "dHybrid: A massively parallel code for hybrid simulations of space plasmas", Computer Physics Communications, Volume 176, Issue 6, Pages 419-425, 15 March 2007, doi:10.1016/j.cpc.2006.11.013

Teaching Fraunhofer diffraction via experimental and simulated images in the laboratory

NASA Astrophysics Data System (ADS)

Peinado, Alba; Vidal, Josep; Escalera, Juan Carlos; Lizana, Angel; Campos, Juan; Yzuel, Maria

2012-10-01

Diffraction is an important phenomenon introduced to Physics university students in a subject of Fundamentals of Optics. In addition, in the Physics Degree syllabus of the Universitat Autònoma de Barcelona, there is an elective subject in Applied Optics. In this subject, diverse diffraction concepts are discussed in-depth from different points of view: theory, experiments in the laboratory and computing exercises. In this work, we have focused on the process of teaching Fraunhofer diffraction through laboratory training. Our approach involves students working in small groups. They visualize and acquire some important diffraction patterns with a CCD camera, such as those produced by a slit, a circular aperture or a grating. First, each group calibrates the CCD camera, that is to say, they obtain the relation between the distances in the diffraction plane in millimeters and in the computer screen in pixels. Afterwards, they measure the significant distances in the diffraction patterns and using the appropriate diffraction formalism, they calculate the size of the analyzed apertures. Concomitantly, students grasp the convolution theorem in the Fourier domain by analyzing the diffraction of 2-D gratings of elemental apertures. Finally, the learners use a specific software to simulate diffraction patterns of different apertures. They can control several parameters: shape, size and number of apertures, 1-D or 2-D gratings, wavelength, focal lens or pixel size.Therefore, the program allows them to reproduce the images obtained experimentally, and generate others by changingcertain parameters. This software has been created in our research group, and it is freely distributed to the students in order to help their learning of diffraction. We have observed that these hands on experiments help students to consolidate their theoretical knowledge of diffraction in a pedagogical and stimulating learning process.

May 2003 Working Group Meeting on Heavy Vehicle Aerodynamic Drag: Presentations and Summary of Comments and Conclusions

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCallen, R; Salari, K; Ortega, J

2003-05-01

A Working Group Meeting on Heavy Vehicle Aerodynamic Drag was held at Lawrence Livermore National Laboratory on May 29-30, 2003. The purpose of the meeting was to present and discuss suggested guidance and direction for the design of drag reduction devices determined from experimental and computational studies. Representatives from the Department of Energy (DOE)/Office of Energy Efficiency and Renewable Energy/Office of FreedomCAR & Vehicle Technologies, Lawrence Livermore National Laboratory (LLNL), Sandia National Laboratories (SNL), NASA Ames Research Center (NASA), University of Southern California (USC), California Institute of Technology (Caltech), Georgia Tech Research Institute (GTRI), Argonne National Laboratory (ANL), Clarkson University,more » and PACCAR participated in the meeting. This report contains the technical presentations (viewgraphs) delivered at the Meeting, briefly summarizes the comments and conclusions, provides some highlighted items, and outlines the future action items.« less

Non-Invasive Pneumothorax Detector Final Report CRADA No. TC02110.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, J. T.; Purcell, R.

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and ElectroSonics Medical Inc. (formerly known as BIOMEC, Inc.), to develop a non-invasive pneumothorax detector based upon the micropower impulse radar technology invented at LLNL. Under a Work for Others Subcontract (L-9248), LLNL and ElectroSonics successfully demonstrated the feasibility of a novel device for non-invasive detection of pneumothorax for emergency and long-term monitoring. The device is based on Micropower Impulse Radar (MIR) Ultra Wideband (UWB) technology. Phase I experimental results were promising, showing that a pneumothorax volume even asmore » small as 30 ml was clearly detectable from the MIR signals. Phase I results contributed to the award of a National Institute of Health (NIH) SBIR Phase II grant to support further research and development. The Phase II award led to the establishment of a LLNL/ElectroSonics CRADA related to Case No. TC02045.0. Under the subsequent CRADA, LLNL and ElectroSonics successfully demonstrated the feasibility of the pneumothorax detection in human subject research trials. Under this current CRADA TC02110.0, also referred to as Phase II Type II, the project scope consisted of seven tasks in Project Year 1; five tasks in Project Year 2; and four tasks in Project Year 3. Year 1 tasks were aimed toward the delivery of the pneumothorax detector design package for the pre-production of the miniaturized CompactFlash dockable version of the system. The tasks in Project Years 2 and 3 critically depended upon the accomplishments of Task 1. Since LLNL’s task was to provide subject matter expertise and performance verification, much of the timeline of engagement by the LLNL staff depended upon the overall project milestones as determined by the lead organization ElectroSonics. The scope of efforts were subsequently adjusted accordingly to commensurate with funding

New Experimental Results of Simulating Micrometeoroid Ablation in the Laboratory

NASA Astrophysics Data System (ADS)

Sternovsky, Zoltan; Thomas, Evan; DeLuca, Michael; Janches, Diego; Munsat, Tobin; Plane, John

2017-04-01

A facility is developed to simulate the ablation of micrometeoroids in laboratory conditions, which also allows measuring the ionization probability of the ablated material. An electrostatic dust accelerator is used to generate iron, aluminum and meteoric analog particles with velocities 10-50 km/s. The particles are then introduced into a cell filled with nitrogen, air or carbon dioxide gas with pressures adjustable in the 0.02 - 0.5 Torr range, where the partial or complete ablation of the particle occurs over a short distance. An array of biased electrodes is used to collect the ionized products with spatial resolution along the ablating particles' path, allowing thus the study of the temporal resolution of the process. A new optical observation setup using a 64 channel PMT system was added to the setup to allow the observation of the ablating particle and deceleration of the particle from the neutral drag. A simple ablation model is used to match the observations. For completely ablated particles the total collected charge directly yields the ionization efficiency. The measurements using iron particles in N2 and air are in relatively good agreement with earlier data. The new experimental data using aluminum particles suggest that the neutral drag acting of the particle is smaller than expected.

On the Integration of Remote Experimentation into Undergraduate Laboratories--Pedagogical Approach

ERIC Educational Resources Information Center

Esche, Sven K.

2005-01-01

This paper presents an Internet-based open approach to laboratory instruction. In this article, the author talks about an open laboratory approach using a multi-user multi-device remote facility. This approach involves both the direct contact with the computer-controlled laboratory setup of interest with the students present in the laboratory…

University of Rochester, Laboratory for Laser Energetics

NASA Astrophysics Data System (ADS)

1987-01-01

In FY86 the Laboratory has produced a list of accomplishments in which it takes pride. LLE has met every laser-fusion program milestone to date in a program of research for direct-drive ultraviolet laser fusion originally formulated in 1981. LLE scientists authored or co-authored 135 scientific papers during 1985 to 1986. The collaborative experiments with NRL, LANL, and LLNL have led to a number of important ICF results. The cryogenic target system developed by KMS Fusion for LLE will be used in future high-density experiments on OMEGA to demonstrate the compression of thermonuclear fuel to 100 to 200 times that of solid (20 to 40 g/cm) in a test of the direct-drive concept, as noted in the National Academy of Sciences' report. The excellence of the advanced technology efforts at LLE is illustrated by the establishment of the Ultrafast Science Center by the Department of Defense through the Air Force Office of Scientific Research. Research in the Center will concentrate on bridging the gap between high-speed electronics and ultrafast optics by providing education, research, and development in areas critical to future communications and high-speed computer systems. The Laboratory for Laser Energetics continues its pioneering work on the interaction of intense radiation with matter. This includes inertial-fusion and advanced optical and optical electronics research; training people in the technology and applications of high-power, short-pulse lasers; and interacting with the scientific community, business, industry, and government to promote the growth of laser technology.

Experimental and theoretical study of microalgal competition in laboratory and natural ecosystems

NASA Astrophysics Data System (ADS)

Pisman, T. I.; Somova, L. A.

An important aspect of studying mixed cultures of microalgae is the artificial ecosystems containing algal culture as a regeneration link and a source of vegetable substances. The peculiarities of studying the stability of microalgae mixed cultures in the laboratory and natural environment have been considered in the work. The role of factors most essentially affecting the species structure of phytoplankton community (temperature factor, light intensity, pH environments, elements of mineral nutrition, algal metabolites, predation and fluctuation of environmental conditions) has been displayed. As a result of experimental and theoretical modelling of the microalgae Chlorella vulgaris and Scenedesmus quadricauda competition under limitation on nitrogen, the impossibility of their co-existence has been revealed. Under these conditions Chl. vulgaris turned out to be less competitive than Sc. quadricauda. The influence of the ratio of biogenic elements concentration in the environment, which should be recognized as an independent regulatory factor limiting growth of populations in the community and, thus affecting its structure, has been analyzed.

An easy-to-build remote laboratory with data transfer using the Internet School Experimental System

NASA Astrophysics Data System (ADS)

Schauer, František; Lustig, František; Dvořák, Jiří; Ožvoldová, Miroslava

2008-07-01

The present state of information communication technology makes it possible to devise and run computer-based e-laboratories accessible to any user with a connection to the Internet, equipped with very simple technical means and making full use of web services. Thus, the way is open for a new strategy of physics education with strongly global features, based on experiment and experimentation. We name this strategy integrated e-learning, and remote experiments across the Internet are the foundation for this strategy. We present both pedagogical and technical reasoning for the remote experiments and outline a simple system based on a server-client approach, and on web services and Java applets. We give here an outline of the prospective remote laboratory system with data transfer using the Internet School Experimental System (ISES) as hardware and ISES WEB Control kit as software. This approach enables the simple construction of remote experiments without building any hardware and virtually no programming, using a paste and copy approach with typical prebuilt blocks such as a camera view, controls, graphs, displays, etc. We have set up and operate at present seven experiments, running round the clock, with more than 12 000 connections since 2005. The experiments are widely used in practical teaching of both university and secondary level physics. The recording of the detailed steps the experimentor takes during the measurement enables detailed study of the psychological aspects of running the experiments. The system is ready for a network of universities to start covering the basic set of physics experiments. In conclusion we summarize the results achieved and experiences of using remote experiments built on the ISES hardware system.

Experimental forests, ranges, and watersheds in the Northern Rocky Mountains: A compendium of outdoor laboratories in Utah, Idaho, and Montana

Treesearch

Wyman C. Schmidt; Judy L. Friede

1996-01-01

This is a compendium of experimental forests, ranges, watersheds, and other outdoor laboratories, formally established by the Forest Service and Agricultural Research Service of the U.S. Department of Agriculture, and the universities in Utah, Idaho, and Montana. The purposes, histories, natural resource bases, data bases, past and current studies, locations, and who...

ALPHA SMP SYSTEM(S) Final Report CRADA No. TC-1404-97

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seager, M.; Beaudet, T.

Within the scope of this subcontract, Digital Equipment Corporation (DIGITAL) and the University, through the Lawrence Livermore National Laboratory (LLNL), engaged in joint research and development activities of mutual interest and benefit. The primary objectives of these activities were, for LLNL to improve its capability to perform its mission, and for DIGITAL to develop technical capability complimentary to this mission. The collaborative activities had direct manpower investments by DIGITAL and LLNL. The project was divided into four areas of concern, which were handled concurrently. These areas included Gang Scheduling, Numerical Methods, Applications Development and Code Development Tools.

Experimental Investigation of Mars Science Laboratory Entry Vehicle Aeroheating in AEDC Hypervelocity Tunnel 9

NASA Technical Reports Server (NTRS)

Hollis, Brian R.; Collier, Arnold S.

2017-01-01

An experimental investigation of the aeroheating environment of the Mars Science Laboratory entry vehicle was conducted in the Arnold Engineering Development Complex Hypervelocity Wind Tunnel 9. Testing was performed on a 6-in. (0.1524 m) diameter model in the tunnel's Mach 8 and Mach 10 nozzles at free stream Reynolds numbers from 4.1×10*exp 6)/ft to 49×10(exp 6)/ft and from 1.2×10(exp 6)/ft to 19×10(exp 6)/ft, respectively, using pure nitrogen test gas. These conditions spanned the boundary layer flow regimes from completely laminar to fully turbulent flow over the entire forebody. A computational fluid dynamics study was conducted in support of the wind tunnel testing. Laminar and turbulent solutions were generated for all wind tunnel test conditions and comparisons of predicted heating distributions were performed with the data. These comparisons showed agreement for most cases to within the estimated +/-12% experimental uncertainty margin for fully-laminar or fully-turbulent conditions, while transitional heating data were bounded by laminar and turbulent predictions. These results helped to define uncertainty margins on the use of computational tools for vehicle design.

A State-of-the-Art Experimental Laboratory for Cloud and Cloud-Aerosol Interaction Research

NASA Technical Reports Server (NTRS)

Fremaux, Charles M.; Bushnell, Dennis M.

2011-01-01

The state of the art for predicting climate changes due to increasing greenhouse gasses in the atmosphere with high accuracy is problematic. Confidence intervals on current long-term predictions (on the order of 100 years) are so large that the ability to make informed decisions with regard to optimum strategies for mitigating both the causes of climate change and its effects is in doubt. There is ample evidence in the literature that large sources of uncertainty in current climate models are various aerosol effects. One approach to furthering discovery as well as modeling, and verification and validation (V&V) for cloud-aerosol interactions is use of a large "cloud chamber" in a complimentary role to in-situ and remote sensing measurement approaches. Reproducing all of the complex interactions is not feasible, but it is suggested that the physics of certain key processes can be established in a laboratory setting so that relevant fluid-dynamic and cloud-aerosol phenomena can be experimentally simulated and studied in a controlled environment. This report presents a high-level argument for significantly improved laboratory capability, and is meant to serve as a starting point for stimulating discussion within the climate science and other interested communities.

Hyperspectral Sensors Final Report CRADA No. TC02173.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Priest, R. E.; Sauvageau, J. E.

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Science Applications International Corporation (SAIC), National Security Space Operations/SRBU, to develop longwave infrared (LWIR) hyperspectral imaging (HSI) sensors for airborne and potentially ground and space, platforms. LLNL has designed and developed LWIR HSI sensors since 1995. The current generation of these sensors has applications to users within the U.S. Department of Defense and the Intelligence Community. User needs are for multiple copies provided by commercial industry. To gain the most benefit from the U.S. Government’s prior investments inmore » LWIR HSI sensors developed at LLNL, transfer of technology and know-how from LLNL HSI experts to commercial industry was needed. The overarching purpose of the CRADA project was to facilitate the transfer of the necessary technology from LLNL to SAIC thereby allowing the U.S. Government to procure LWIR HSI sensors from this company.« less

Studies of Short Time Response Options for Potentially Hazardous Objects: Current and Forthcoming Results

NASA Technical Reports Server (NTRS)

Barbee, Brent W.; Greenaugh, Kevin C.; Seery, Bernard D.; Bambacus, Myra; Leung, Ronald Y.; Finewood, Lee; Dearborn, David S. P.; Miller, Paul L.; Weaver, Robert P.; Plesko, Catherine;

Experimental and operational modal analysis of a laboratory scale model of a tripod support structure.

NASA Astrophysics Data System (ADS)

Luczak, M. M.; Mucchi, E.; Telega, J.

2016-09-01

The goal of the research is to develop a vibration-based procedure for the identification of structural failures in a laboratory scale model of a tripod supporting structure of an offshore wind turbine. In particular, this paper presents an experimental campaign on the scale model tested in two stages. Stage one encompassed the model tripod structure tested in air. The second stage was done in water. The tripod model structure allows to investigate the propagation of a circumferential representative crack of a cylindrical upper brace. The in-water test configuration included the tower with three bladed rotor. The response of the structure to the different waves loads were measured with accelerometers. Experimental and operational modal analysis was applied to identify the dynamic properties of the investigated scale model for intact and damaged state with different excitations and wave patterns. A comprehensive test matrix allows to assess the differences in estimated modal parameters due to damage or as potentially introduced by nonlinear structural response. The presented technique proves to be effective for detecting and assessing the presence of representative cracks.

Electron-Beam Vapor Deposition of Mold Inserts Final Report CRADA No. TSB-777-94

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shepp, T.; Feeley, T.

Lawrence Livermore National Laboratory and H.G.G. Laser Fare, Inc. studied the application of electron-beam vapor deposition technology to the production of mold inserts for use in an injection molding machine by Laser Fare. Laser Fare provided LLNL with the requirements of the mold inserts as well as sample inserts. LLNL replicated the mold insert(s) to Laser Fare for testing by Laser Fare.

Laboratory prototype for experimental validation of MR-guided radiofrequency head and neck hyperthermia

NASA Astrophysics Data System (ADS)

Paulides, M. M.; Bakker, J. F.; Hofstetter, L. W.; Numan, W. C. M.; Pellicer, R.; Fiveland, E. W.; Tarasek, M.; Houston, G. C.; van Rhoon, G. C.; Yeo, D. T. B.; Kotek, G.

2014-05-01

Clinical studies have established a strong benefit from adjuvant mild hyperthermia (HT) to radio- and chemotherapy for many tumor sites, including the head and neck (H&N). The recently developed HYPERcollar allows the application of local radiofrequency HT to tumors in the entire H&N. Treatment quality is optimized using electromagnetic and thermal simulators and, whenever placement risk is tolerable, assessed using invasively placed thermometers. To replace the current invasive procedure, we are investigating whether magnetic resonance (MR) thermometry can be exploited for continuous and 3D thermal dose assessment. In this work, we used our simulation tools to design an MR compatible laboratory prototype applicator. By simulations and measurements, we showed that the redesigned patch antennas are well matched to 50 Ω (S11<-10 dB). Simulations also show that, using 300 W input power, a maximum specific absorption rate (SAR) of 100 W kg-1 and a temperature increase of 4.5 °C in 6 min is feasible at the center of a cylindrical fat/muscle phantom. Temperature measurements using the MR scanner confirmed the focused heating capabilities and MR compatibility of the setup. We conclude that the laboratory applicator provides the possibility for experimental assessment of the feasibility of hybrid MR-HT in the H&N region. This versatile design allows rigorous analysis of MR thermometry accuracy in increasingly complex phantoms that mimic patients' anatomies and thermodynamic characteristics.

Waste Isolation Pilot Plant Technical Assessment Team Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

This report provides the results of the Waste Isolation Pilot Plant (WIPP) technical assessment led by the Savannah River National Laboratory and conducted by a team of experts in pertinent disciplines from SRNL and Lawrence Livermore National Laboratory (LLNL), Oak Ridge National Laboratory (ORNL), Pacific Northwest National Laboratory (PNNL), and Sandia National Laboratories (SNL).

Experimental Investigation of Ternary Alloys for Fusion Breeding Blankets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Choi, B. William; Chiu, Ing L.

Future fusion power plants based on the deuterium-tritium (DT) fuel cycle will be required to breed the T fuel via neutron reactions with lithium, which will be incorporated in a breeding blanket that surrounds the fusion source. Recent work by LLNL proposed the used of liquid Li as the breeder in an inertial fusion energy (IFE) power plant. Subsequently, an LDRD was initiated to develop alternatives ternary alloy liquid metal breeders that have reduced chemical reactivity with water and air compared to pure Li. Part of the work plan was to experimentally investigate the phase diagrams of ternary alloys. Ofmore » particular interest was measurement of the melt temperature, which must be low enough to be compatible with the temperature limits of the steel used in the construction of the chamber and heat transfer system.« less

Challenges in small screening laboratories: implementing an on-demand laboratory information management system.

PubMed

Lemmon, Vance P; Jia, Yuanyuan; Shi, Yan; Holbrook, S Douglas; Bixby, John L; Buchser, William

2011-11-01

The Miami Project to Cure Paralysis, part of the University of Miami Miller School of Medicine, includes a laboratory devoted to High Content Analysis (HCA) of neurons. The goal of the laboratory is to uncover signaling pathways, genes, compounds, or drugs that can be used to promote nerve growth. HCA permits the quantification of neuronal morphology, including the lengths and numbers of axons. HCA of various libraries on primary neurons requires a team-based approach, a variety of process steps and complex manipulations of cells and libraries to obtain meaningful results. HCA itself produces vast amounts of information including images, well-based data and cell-based phenotypic measures. Documenting and integrating the experimental workflows, library data and extensive experimental results is challenging. For academic laboratories generating large data sets from experiments involving thousands of perturbagens, a Laboratory Information Management System (LIMS) is the data tracking solution of choice. With both productivity and efficiency as driving rationales, the Miami Project has equipped its HCA laboratory with an On Demand or Software As A Service (SaaS) LIMS to ensure the quality of its experiments and workflows. The article discusses how the system was selected and integrated into the laboratory. The advantages of a SaaS based LIMS over a client-server based system are described. © 2011 Bentham Science Publishers

International Intercomparison Exercise for Nuclear Accident Dosimetry at the DAF Using GODIVA-IV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hickman, David; Hudson, Becka

The Nuclear Criticality Safety Program operated under the direction of Dr. Jerry McKamy completed the first NNSA Nuclear Accident Dosimetry exercise on May 27, 2016. Participants in the exercise were from Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), Sandia National Laboratory (SNL), Savanah River Site (SRS), Pacific Northwest National Laboratory (PNNL), US Navy, the Atomic Weapons Establishment (United Kingdom) under the auspices of JOWOG 30, and the Institute for Radiological Protection and Nuclear Safety (France) by special invitation and NCSP memorandum of understanding. This exercise was the culmination of a series of Integral Experiment Requests (IER) thatmore » included the establishment of the Nuclear Criticality Experimental Research Center, (NCERC) the startup of the Godiva Reactor (IER-194), the establishment of a the Nuclear Accident Dosimetry Laboratory (NAD LAB) in Mercury, NV, and the determination of reference dosimetry values for the mixed neutron and photon radiation field of Godiva within NCERC.« less

Emergency Response Capability Baseline Needs Assessment - Compliance Assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sharry, John A.

This document was prepared by John A. Sharry, LLNL Fire Marshal and Division Leader for Fire Protection and was reviewed by LLNL Emergency Management Department Head, James Colson. This document is the second of a two-part analysis on Emergency Response Capabilities of Lawrence Livermore National Laboratory. The first part, 2016 Baseline Needs Assessment Requirements Document established the minimum performance criteria necessary to meet mandatory requirements. This second part analyses the performance of Lawrence Livermore Laboratory Emergency Management Department to the contents of the Requirements Document. The document was prepared based on an extensive review of information contained in the 2016more » BNA, a review of Emergency Planning Hazards Assessments, a review of building construction, occupancy, fire protection features, dispatch records, LLNL alarm system records, fire department training records, and fire department policies and procedures. The 2013 BNA was approved by NNSA’s Livermore Field Office on January 22, 2014.« less

Intelligent software for laboratory automation.

PubMed

Whelan, Ken E; King, Ross D

2004-09-01

The automation of laboratory techniques has greatly increased the number of experiments that can be carried out in the chemical and biological sciences. Until recently, this automation has focused primarily on improving hardware. Here we argue that future advances will concentrate on intelligent software to integrate physical experimentation and results analysis with hypothesis formulation and experiment planning. To illustrate our thesis, we describe the 'Robot Scientist' - the first physically implemented example of such a closed loop system. In the Robot Scientist, experimentation is performed by a laboratory robot, hypotheses concerning the results are generated by machine learning and experiments are allocated and selected by a combination of techniques derived from artificial intelligence research. The performance of the Robot Scientist has been evaluated by a rediscovery task based on yeast functional genomics. The Robot Scientist is proof that the integration of programmable laboratory hardware and intelligent software can be used to develop increasingly automated laboratories.

Applied Physics Laboratory, An Experimental Program for Aerospace Education, 12th Year.

ERIC Educational Resources Information Center

Abramson, David A.

This physics laboratory manual is the result of curriculum development begun at Aviation High School (New York City) in 1967. It represents a semester of advanced laboratory work for those students who have completed the usual course in physics. The 91 laboratory experiments included in the manual have been developed and modified through use for…

Whole Class Laboratories: More Examples

ERIC Educational Resources Information Center

Kouh, Minjoon

2016-01-01

Typically, introductory physics courses are taught with a combination of lectures and laboratories in which students have opportunities to discover the natural laws through hands-on activities in small groups. This article reports the use of Google Drive, a free online document-sharing tool, in physics laboratories for pooling experimental data…

A laboratory animal science pioneer.

PubMed

Kostomitsopoulos, Nikolaos

2014-11-01

Nikolaos Kostomitsopoulos, DVM, PhD, is Head of Laboratory Animal Facilities and Designated Veterinarian, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece. Dr. Kostomitsopoulos discusses his successes in implementing laboratory animal science legislation and fostering collaboration among scientists in Greece.

Investigation of Weibel-filament growth in the nonlinear regime using laser-irradiated foils of different materials

NASA Astrophysics Data System (ADS)

Manuel, Mario

2017-10-01

M.J.-E. MANUEL GENERAL ATOMICS, C.M. HUNTINGTON, D.P. HIGGINSON, B.B. POLLOCK, B.A. REMINGTON, H. RINDERKNECHT, J.S. ROSS, D. RYUTOV, G. SWADLING, S. WILKS, A.B. ZYLSTRA, H.-S. PARK LLNL, F. FIUZA, S. TOTORICASLAC, G. GREGORIOXFORD, J. PARK, A. SPITKOVSKYPRINCETON, Y. SAKAWA, H. TAKABEOSAKA, H. SIOMIT, A.B. ZYLSTRALANL. The Weibel instability is presently the leading mechanism proposed to amplify magnetic fields necessary to form `collisionless' shocks in weakly magnetized astrophysical systems, including young supernova remnants and gamma-ray bursts. These systems rely on the presence of strong self-generated magnetic fields to mediate shock formation since the typical collisional mean-free-path is much larger than the system size. The work presented here investigates the development of the Weibel instability in the nonlinear regime through experimental variation of plasma parameters using different ion species and separation distances. Our goal is to investigate the underlying physical mechanism that may allow the formation of collisionless shocks in astrophysical objects. Recent experimental and computational results will be presented and discussed. This work is funded by the NNSA-DS and SC-OFES Joint Program in High-Energy-Density Laboratory Plasmas, Grant Number DE-NA0002956 and in collaboration with LLNL under contract DE-AC52-07NA27344.

Overview of the National Ignition Campaign (NIC)

NASA Astrophysics Data System (ADS)

Moses, Edward

2010-11-01

The 192-beam National Ignition Facility (NIF) at Lawrence Livermore National Laboratory (LLNL) is now operational. NIF has conducted 192-beam implosion experiments with energies as high as 1.2 MJ and has also demonstrated the unprecedented energy and pulse shaping control required for ignition experiments. The successful commissioning of the NIF laser is the first step in demonstrating inertial confinement fusion (ICF) ignition in the laboratory. The NIF ignition program is executed via the National Ignition Campaign (NIC)---a partnership between Los Alamos National Laboratory, Lawrence Berkeley Laboratory, LLNL, General Atomics, the University of Rochester Laboratory for Laser Energetics, Sandia National Laboratories, the Massachusetts Institute of Technology, and other national and international partners. The NIC relies on a novel integrated experimental and computational program to tune the target to the conditions required for indirect-drive ignition. This approach breaks the tuning process into four phases. The first two phases involve tuning of the hohlraum and capsule to produce the correct radiation drive, symmetry, and shock timing conditions. The third phase consists of layered cryogenic implosions conducted with a 50%/49%/1% mixture of tritium, hydrogen, and deuterium (THD) respectively. The reduced yield from these THD targets allows the full diagnostic suite to be employed and the presence of the required temperature and fuel areal density to be verified. The final step is DT ignition implosions with expected gains of 10-20. DT ignition experiments will be conducted with Elaser ˜1.2 MJ. Laser energies of 1.8 MJ should be available for subsequent experiments. This talk will review the multi-phase tuning approach to the ignition effort, including the physics issues associated with the various steps, and current and future plans for the NIF ignition program.

Laboratory investigations of earthquake dynamics

NASA Astrophysics Data System (ADS)

Xia, Kaiwen

In this thesis this will be attempted through controlled laboratory experiments that are designed to mimic natural earthquake scenarios. The earthquake dynamic rupturing process itself is a complicated phenomenon, involving dynamic friction, wave propagation, and heat production. Because controlled experiments can produce results without assumptions needed in theoretical and numerical analysis, the experimental method is thus advantageous over theoretical and numerical methods. Our laboratory fault is composed of carefully cut photoelastic polymer plates (Homahte-100, Polycarbonate) held together by uniaxial compression. As a unique unit of the experimental design, a controlled exploding wire technique provides the triggering mechanism of laboratory earthquakes. Three important components of real earthquakes (i.e., pre-existing fault, tectonic loading, and triggering mechanism) correspond to and are simulated by frictional contact, uniaxial compression, and the exploding wire technique. Dynamic rupturing processes are visualized using the photoelastic method and are recorded via a high-speed camera. Our experimental methodology, which is full-field, in situ, and non-intrusive, has better control and diagnostic capacity compared to other existing experimental methods. Using this experimental approach, we have investigated several problems: dynamics of earthquake faulting occurring along homogeneous faults separating identical materials, earthquake faulting along inhomogeneous faults separating materials with different wave speeds, and earthquake faulting along faults with a finite low wave speed fault core. We have observed supershear ruptures, subRayleigh to supershear rupture transition, crack-like to pulse-like rupture transition, self-healing (Heaton) pulse, and rupture directionality.

Investigating Student Perceptions of the Chemistry Laboratory and Their Approaches to Learning in the Laboratory

NASA Astrophysics Data System (ADS)

Berger, Spencer Granett

laboratory procedures. In order to test the effects of the intervention, an experimental group (N=87) completed these supplementary questions during two laboratory experiments while a control group (N=84) performed the same experiments without these additional questions. The effects of the intervention on laboratory exam performance were measured. Students in the experimental group had a higher average on the laboratory exam than students in the control group.

Centers for Disease Control and Prevention (CDC) Radiation Hazard Scale Data Product Review Feedback Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Askin, A.; Buddemeier, B.; Alai, M.

In support of the Department of Energy (DOE) National nuclear Security Administration (NNSA) and the Centers for Disease Control and Prevention (CDC), Lawrence Livermore National Laboratory (LLNL) assisted in the development of new data templates for disseminating and communicating FRMAC1 data products using the CDC Radiation Hazard Scale communication tool. To ensure these data products will be useful to stakeholders during a radiological emergency, LLNL facilitated opportunities for product socialization and review.

Spectral Diagnostics of Galactic and Stellar X-Ray Emission from Charge Exchange Recombination

NASA Technical Reports Server (NTRS)

Wargelin, B.

2002-01-01

The proposed research uses the electron beam ion trap at the Lawrence Livermore National Laboratory (LLNL) to study X-ray emission from charge-exchange recombination of highly charged ions with neutral gases. The resulting data fill a void in existing experimental and theoretical understanding of this atomic physics process, and are needed to explain all or part of the observed X-ray emission from the soft X-ray background, stellar winds, the Galactic Center, supernova ejecta, and photoionized nebulae. Progress made during the first year of the grant is described, as is work planned for the second year.

Experimental demonstration of the anti-maser

NASA Astrophysics Data System (ADS)

Mazzocco, Anthony; Aviles, Michael; Andrews, Jim; Dawson, Nathan; Crescimanno, Michael

2012-10-01

We denote by ``anti-maser'' a coherent perfect absorption (CPA) process in the radio frequency domain. We demonstrate several experimental realizations of the anti-maser suitable for an advanced undergraduate laboratory. Students designed, assembled and tested these devices, as well as the inexpensive laboratory setup and experimental protocol for displaying various CPA phenomenon.

A new laboratory-scale experimental facility for detailed aerothermal characterizations of volumetric absorbers

NASA Astrophysics Data System (ADS)

Gomez-Garcia, Fabrisio; Santiago, Sergio; Luque, Salvador; Romero, Manuel; Gonzalez-Aguilar, Jose

2016-05-01

This paper describes a new modular laboratory-scale experimental facility that was designed to conduct detailed aerothermal characterizations of volumetric absorbers for use in concentrating solar power plants. Absorbers are generally considered to be the element with the highest potential for efficiency gains in solar thermal energy systems. The configu-ration of volumetric absorbers enables concentrated solar radiation to penetrate deep into their solid structure, where it is progressively absorbed, prior to being transferred by convection to a working fluid flowing through the structure. Current design trends towards higher absorber outlet temperatures have led to the use of complex intricate geometries in novel ceramic and metallic elements to maximize the temperature deep inside the structure (thus reducing thermal emission losses at the front surface and increasing efficiency). Although numerical models simulate the conjugate heat transfer mechanisms along volumetric absorbers, they lack, in many cases, the accuracy that is required for precise aerothermal validations. The present work aims to aid this objective by the design, development, commissioning and operation of a new experimental facility which consists of a 7 kWe (1.2 kWth) high flux solar simulator, a radiation homogenizer, inlet and outlet collector modules and a working section that can accommodate volumetric absorbers up to 80 mm × 80 mm in cross-sectional area. Experimental measurements conducted in the facility include absorber solid temperature distributions along its depth, inlet and outlet air temperatures, air mass flow rate and pressure drop, incident radiative heat flux, and overall thermal efficiency. In addition, two windows allow for the direct visualization of the front and rear absorber surfaces, thus enabling full-coverage surface temperature measurements by thermal imaging cameras. This paper presents the results from the aerothermal characterization of a siliconized silicon

September 2002 Working Group Meeting on Heavy Vehicle Aerodynamic Drag: Presentations and Summary of Comments and Conclusions

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCallen, R

2002-09-01

A Working Group Meeting on Heavy Vehicle Aerodynamic Drag was held at NASA Ames Research Center on September 23, 2002. The purpose of the meeting was to present and discuss technical details on the experimental and computational work in progress and future project plans. Representatives from the Department of Energy (DOE)/Office of Energy Efficiency and Renewable Energy/Office of FreedomCAR & Vehicle Technologies, Lawrence Livermore National Laboratory (LLNL), Sandia National Laboratories (SNL), NASA Ames Research Center (NASA), University of Southern California (USC), California Institute of Technology (Caltech), Georgia Tech Research Institute (GTRI), Argonne National Laboratory (ANL), Freightliner, and Portland State Universitymore » participated in the meeting. This report contains the technical presentations (viewgraphs) delivered at the Meeting, briefly summarizes the comments and conclusions, and outlines the future action items. The meeting began with an introduction by the Project Lead Rose McCallen of LLNL, where she emphasized that the world energy consumption is predicted to relatively soon exceed the available resources (i.e., fossil, hydro, non-breeder fission). This short fall is predicted to begin around the year 2050. Minimizing vehicle aerodynamic drag will significantly reduce our Nation's dependence on foreign oil resources and help with our world-wide fuel shortage. Rose also mentioned that educating the populace and researchers as to our world energy issues is important and that our upcoming United Engineering Foundation (UEF) Conference on ''The Aerodynamics of Heavy Vehicles: Trucks, Busses, and Trains'' was one way our DOE Consortium was doing this. Mentioned were the efforts of Fred Browand from USC in organizing and attracting internationally recognized speakers to the Conference. Rose followed with an overview of the DOE project goals, deliverables, and FY03 activities. The viewgraphs are attached at the end of this report. Sid Diamond

A framework for accelerated phototrophic bioprocess development: integration of parallelized microscale cultivation, laboratory automation and Kriging-assisted experimental design.

PubMed

Morschett, Holger; Freier, Lars; Rohde, Jannis; Wiechert, Wolfgang; von Lieres, Eric; Oldiges, Marco

2017-01-01

Even though microalgae-derived biodiesel has regained interest within the last decade, industrial production is still challenging for economic reasons. Besides reactor design, as well as value chain and strain engineering, laborious and slow early-stage parameter optimization represents a major drawback. The present study introduces a framework for the accelerated development of phototrophic bioprocesses. A state-of-the-art micro-photobioreactor supported by a liquid-handling robot for automated medium preparation and product quantification was used. To take full advantage of the technology's experimental capacity, Kriging-assisted experimental design was integrated to enable highly efficient execution of screening applications. The resulting platform was used for medium optimization of a lipid production process using Chlorella vulgaris toward maximum volumetric productivity. Within only four experimental rounds, lipid production was increased approximately threefold to 212 ± 11 mg L -1  d -1 . Besides nitrogen availability as a key parameter, magnesium, calcium and various trace elements were shown to be of crucial importance. Here, synergistic multi-parameter interactions as revealed by the experimental design introduced significant further optimization potential. The integration of parallelized microscale cultivation, laboratory automation and Kriging-assisted experimental design proved to be a fruitful tool for the accelerated development of phototrophic bioprocesses. By means of the proposed technology, the targeted optimization task was conducted in a very timely and material-efficient manner.

A multivariate assessment of the effect of the laboratory homework component of a microcomputer-based laboratory for a college freshman physics course

NASA Astrophysics Data System (ADS)

Ramlo, Susan E.

Microcomputer-based laboratories (MBLs) have been defined as software that uses an electronic probe to collect information about a physical system and then converts that information into graphical systems in real-time. Realtime Physics Laboratories (RTP) are an example of laboratories that combine the use of MBLs with collaboration and guided-inquiry. RTP Mechanics Laboratories include both laboratory activities and laboratory homework for the first semester of college freshman physics courses. Prior research has investigated the effectiveness of the RTP laboratories as a package (laboratory activities with laboratory homework). In this study, an experimental-treatment had students complete both the RTP laboratory activity and the associated laboratory homework during the same laboratory period. Observations of this treatment indicated that students primarily consulted the laboratory instructor and referred to their completed laboratory activity while completing the homework in their collaborative groups. In the control-treatment, students completed the laboratory homework outside the laboratory period. Measures of force and motion conceptual understanding included the Force and Motion Conceptual Understanding (FMCE), a 47 multiple-choice question test. Analyses of the FMCE indicated that it is both a reliable and a valid measure of force and motion conceptual understanding. A distinct, five-factor structure for the FMCE post-test answers reflected specific concepts related to force and motion. However, the three FMCE pretest factors were less distinct. Analysis of the experimental-treatment, compared to a control-treatment, included multiple regression analysis with covariates of age, prior physics-classroom experience, and the three FMCE pretest factors. Criterion variables included each of the five post-test factors, the total laboratory homework score, and a group of seven exam questions. The results were all positive, in favor of the experimental

ARGUS/LLNL IR Camera Calibration and Characterization

DTIC Science & Technology

1989-11-01

122 of the 244 rows, once every 1/60 second. The even-numbered detector rows, beginning with row zero , are read out in one field; the odd-numbered...Radiometrically, a very cold reference scene is desirable because the absolute signal level of the reference scene is subtracted from all subsequent...to have effectively zero radiant energy within the spectral passband of the sensor, and so may be ignored. 1.3 LABORATORY EQUIPMENT CONFIGURATION The

Project Management Plan for the Idaho National Engineering Laboratory Waste Isolation Pilot Plant Experimental Test Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Connolly, M.J.; Sayer, D.L.

1993-11-01

EG&G Idaho, Inc. and Argonne National Laboratory-West (ANL-W) are participating in the Idaho National Engineering Laboratory`s (INEL`s) Waste Isolation Pilot Plant (WIPP) Experimental Test Program (WETP). The purpose of the INEL WET is to provide chemical, physical, and radiochemical data on transuranic (TRU) waste to be stored at WIPP. The waste characterization data collected will be used to support the WIPP Performance Assessment (PA), development of the disposal No-Migration Variance Petition (NMVP), and to support the WIPP disposal decision. The PA is an analysis required by the Code of Federal Regulations (CFR), Title 40, Part 191 (40 CFR 191), whichmore » identifies the processes and events that may affect the disposal system (WIPP) and examines the effects of those processes and events on the performance of WIPP. A NMVP is required for the WIPP by 40 CFR 268 in order to dispose of land disposal restriction (LDR) mixed TRU waste in WIPP. It is anticipated that the detailed Resource Conservation and Recovery Act (RCRA) waste characterization data of all INEL retrievably-stored TRU waste to be stored in WIPP will be required for the NMVP. Waste characterization requirements for PA and RCRA may not necessarily be identical. Waste characterization requirements for the PA will be defined by Sandia National Laboratories. The requirements for RCRA are defined in 40 CFR 268, WIPP RCRA Part B Application Waste Analysis Plan (WAP), and WIPP Waste Characterization Program Plan (WWCP). This Project Management Plan (PMP) addresses only the characterization of the contact handled (CH) TRU waste at the INEL. This document will address all work in which EG&G Idaho is responsible concerning the INEL WETP. Even though EG&G Idaho has no responsibility for the work that ANL-W is performing, EG&G Idaho will keep a current status and provide a project coordination effort with ANL-W to ensure that the INEL, as a whole, is effectively and efficiently completing the requirements

DHS-STEM Internship at Lawrence Livermore National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feldman, B

2008-08-18

This summer I had the fortunate opportunity through the DHS-STEM program to attend Lawrence Livermore National Laboratories (LLNL) to work with Tom Slezak on the bioinformatics team. The bioinformatics team, among other things, helps to develop TaqMan and microarray probes for the identification of pathogens. My main project at the laboratory was to test such probe identification capabilities against metagenomic (unsequenced) data from around the world. Using various sequence analysis tools (Vmatch and Blastall) and several we developed ourselves, about 120 metagenomic sequencing projects were compared against a collection of all completely sequenced genomes and Lawrence Livermore National Laboratory's (LLNL)more » current probe database. For the probes, the Blastall algorithms compared each individual metagenomic project using various parameters allowing for the natural ambiguities of in vitro hybridization (mismatches, deletions, insertions, hairpinning, etc.). A low level cutoff was used to eliminate poor sequence matches, and to leave a large variety of higher quality matches for future research into the hybridization of sequences with mutations and variations. Any hits with at least 80% base pair conservation over 80% of the length of the match. Because of the size of our whole genome database, we utilized the exact match algorithm of Vmatch to quickly search and compare genomes for exact matches with varying lower level limits on sequence length. I also provided preliminary feasibility analyses to support a potential industry-funded project to develop a multiplex assay on several genera and species. Each genus and species was evaluated based on the amount of sequenced genomes, amount of near neighbor sequenced genomes, presence of identifying genes--metabolistic or antibiotic resistant genes--and the availability of research on the identification of the specific genera or species. Utilizing the bioinformatic team's software, I was able to develop and

Teaching Cardiovascular Integrations with Computer Laboratories.

ERIC Educational Resources Information Center

Peterson, Nils S.; Campbell, Kenneth B.

1985-01-01

Describes a computer-based instructional unit in cardiovascular physiology. The program (which employs simulated laboratory experimental techniques with a problem-solving format is designed to supplement an animal laboratory and to offer students an integrative approach to physiology through use of microcomputers. Also presents an overview of the…

An experimental paradigm to compare motor performance under laboratory and under everyday-like conditions.

PubMed

Bock, Otmar; Hagemann, Anne

2010-10-30

Research findings on human motor skills may not necessarily hold in everyday life, since laboratory and everyday scenarios typically differ with respect to the subjects' attention to the skill, their motivation to perform at their best, the goals they try to achieve, and the mode of movement initiation - extrinsic versus intrinsic. Here we present an experimental approach which can be used to substantiate the hypothesized effects of laboratory (L) versus everyday (E) settings on one type of motor skill, i.e., manual prehension. This approach is based on two tasks: In task L, subjects are told that they will participate in an experiment on grasping, and are instructed to seize and move a lever upon appearance of a visual target. In task E, they are told that they will play a computer game, and they have to seize and move the lever in order to proceed from one game level to the next. Both tasks include prehension movements from the same starting position and object to the same terminal position and object; movements differ only in their behavioural context. We exemplify the utility of our approach with a preliminary analysis of kinematic and force data. It shows that the two tasks differ with respect to several performance measures, and that some performance measures make independent contributions to that difference. The existence of independent contributions suggests that behavioural context may influence prehension via several distinct routes. Our approach can be used for comprehensive analyses of the context-dependence of motor skills in various reference groups. Copyright © 2010 Elsevier B.V. All rights reserved.

Human Laboratory Paradigms in Alcohol Research

PubMed Central

Plebani, Jennifer G.; Ray, Lara A.; Morean, Meghan E.; Corbin, William R.; Mackillop, James; Amlung, Michael; King, Andrea C.

2014-01-01

Human laboratory studies have a long and rich history in the field of alcoholism. Human laboratory studies have allowed for advances in alcohol research in a variety of ways, including elucidating of the neurobehavioral mechanisms of risk, identifying phenotypically distinct sub-types of alcohol users, investigating of candidate genes underlying experimental phenotypes for alcoholism, and testing mechanisms of action of alcoholism pharmacotherapies on clinically-relevant translational phenotypes, such as persons exhibiting positive-like alcohol effects or alcohol craving. Importantly, the field of human laboratory studies in addiction has progressed rapidly over the past decade and has built upon earlier findings of alcohol's neuropharmacological effects to advancing translational research on alcoholism etiology and treatment. To that end, the new generation of human laboratory studies has focused on applying new methodologies, further refining alcoholism phenotypes, and translating these findings to studies of alcoholism genetics, medication development, and pharmacogenetics. The combination of experimental laboratory approaches with recent developments in neuroscience and pharmacology has been particularly fruitful in furthering our understanding of the impact of individual differences in alcoholism risk and in treatment response. This review of the literature focuses on human laboratory studies of subjective intoxication, alcohol craving, anxiety, and behavioral economics. Each section discusses opportunities for phenotype refinement under laboratory conditions, as well as its application to translational science of alcoholism. A summary and recommendations for future research are also provided. PMID:22309888

Experiments and simulations of single shock Richtmeyer-Meshkov Instability with measured, volumetric initial conditions

NASA Astrophysics Data System (ADS)

Sewell, Everest; Ferguson, Kevin; Greenough, Jeffrey; Jacobs, Jeffrey

2014-11-01

We describe new experiments of single shock Richtmeyer-Meshkov Instability (RMI) performed on the shock tube apparatus at the University of Arizona in which the initial conditions are volumetrically imaged prior to shock wave arrival. Initial perturbation plays a major role in the evolution of RMI, and previous experimental efforts only capture a narrow slice of the initial condition. The method presented uses a rastered laser sheet to capture additional images in the depth of the initial condition shortly before the experimental start time. These images are then used to reconstruct a volumetric approximation of the experimental perturbation, which is simulated using the hydrodynamics code ARES, developed at Lawrence Livermore National Laboratory (LLNL). Comparison is made between the time evolution of the interface width and the mixedness ratio measured from the experiments against the predictions from the numerical simulations.

2009 Annual Health Physics Report for the HEU Transparency Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Radev, R

2010-04-14

During the 2009 calendar year, Lawrence Livermore National Laboratory (LLNL) provided health physics support for the Highly Enriched Uranium (HEU) Transparency Program for external and internal radiation protection. LLNL also provided technical expertise related to BDMS radioactive sources and Russian radiation safety regulatory compliance. For the calendar year 2009, there were 159 person-trips that required dose monitoring of the U.S. monitors. Of the 159 person-trips, 149 person-trips were SMVs and 10 person-trips were Transparency Monitoring Office (TMO) trips. There were 4 monitoring visits by TMO monitors to facilities other than UEIE and 10 to UEIE itself. LLNL's Hazard Control Departmentmore » laboratories provided the dosimetry services for the HEU Transparency monitors. In 2009, the HEU Transparency activities in Russia were conducted in a radiologically safe manner for the HEU Transparency monitors in accordance with the expectations of the HEU Transparency staff, NNSA and DOE. The HEU Transparency Program now has over fifteen years of successful experience in developing and providing health and safety support in meeting its technical objectives.« less

An Experimental Study of a BSCS-Style Laboratory Approach for University General Biology.

ERIC Educational Resources Information Center

Leonard, William H.

1983-01-01

A Biological Sciences Curriculum Study (BSCS) inquiry approach for university general biology laboratory was tested against a well-established commercial program judged to be highly directive. The BSCS was found to be more effective in learning biology laboratory concepts than the commercial program as measured by a laboratory concepts test.…

A remote laboratory for USRP-based software defined radio

NASA Astrophysics Data System (ADS)

Gandhinagar Ekanthappa, Rudresh; Escobar, Rodrigo; Matevossian, Achot; Akopian, David

2014-02-01

Electrical and computer engineering graduates need practical working skills with real-world electronic devices, which are addressed to some extent by hands-on laboratories. Deployment capacity of hands-on laboratories is typically constrained due to insufficient equipment availability, facility shortages, and lack of human resources for in-class support and maintenance. At the same time, at many sites, existing experimental systems are usually underutilized due to class scheduling bottlenecks. Nowadays, online education gains popularity and remote laboratories have been suggested to broaden access to experimentation resources. Remote laboratories resolve many problems as various costs can be shared, and student access to instrumentation is facilitated in terms of access time and locations. Labs are converted to homeworks that can be done without physical presence in laboratories. Even though they are not providing full sense of hands-on experimentation, remote labs are a viable alternatives for underserved educational sites. This paper studies remote modality of USRP-based radio-communication labs offered by National Instruments (NI). The labs are offered to graduate and undergraduate students and tentative assessments support feasibility of remote deployments.

A Laboratory Course for Teaching Laboratory Techniques, Experimental Design, Statistical Analysis, and Peer Review Process to Undergraduate Science Students

ERIC Educational Resources Information Center

Gliddon, C. M.; Rosengren, R. J.

2012-01-01

This article describes a 13-week laboratory course called Human Toxicology taught at the University of Otago, New Zealand. This course used a guided inquiry based laboratory coupled with formative assessment and collaborative learning to develop in undergraduate students the skills of problem solving/critical thinking, data interpretation and…

Hydrologic Resources Management Program and Underground Tests Area Project FY 2003 Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

J., B C; F., E G; K., E B

This report describes FY 2003 technical studies conducted by the Chemical Biology and Nuclear Science Division (CBND) at Lawrence Livermore National Laboratory (LLNL) in support of the Hydrologic Resources Management Program (HRMP) and the Underground Test Area (UGTA) Project. These programs are administered by the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) through the Defense Programs and Environmental Restoration Divisions, respectively. HRMP-sponsored work is directed toward the responsible management of the natural resources at the Nevada Test Site (NTS), enabling its continued use as a staging area for strategic operations in support of national security.more » UGTA-funded work emphasizes the development of an integrated set of groundwater flow and contaminant transport models to predict the extent of radionuclide migration from underground nuclear testing areas at the NTS. The present report is organized on a topical basis and contains five chapters that reflect the range of technical work performed by LLNL-CBND during FY 2003. Although we have emphasized investigations that were led by CBND, we also participated in a variety of collaborative studies with other UGTA and HRMP contract organizations including the Energy and Environment Directorate at LLNL (LLNL-E&E), Los Alamos National Laboratory (LANL), the Desert Research Institute (DRI), the U.S. Geological Survey (USGS), Stoller-Navarro Joint Venture (SNJV), and Bechtel Nevada (BN).« less

On the Use of Chicks as Experimental Laboratory Subjects.

ERIC Educational Resources Information Center

Rowland, David L.; And Others

1984-01-01

Chickens, instead of rats, were used in an upper-level laboratory course on animal learning. To help other instructors interested in using chickens for a lab course, a discussion of the physical and behavioral characteristics of chickens is provided. Student reaction to the course is also discussed. (RM)

Chance Favors Only the Prepared Mind: The Proper Role for U.S. Department of Defense Science and Engineering Workforce

DTIC Science & Technology

2013-08-01

establishments staffed by private sector S&Es (Argonne National Laboratory (ANL), Brookhaven National Laboratory ( BNL ), Jet Propulsion Laboratory...21 Table 1 Academy ANL BNL JPL LANL LL LLNL NIH NIST NRL NAE 2 1 4 1 1 1 1 7 8 NAS 4 7 1 3 0 1 52 7 3 IOM 0 0 0 0

Fiscal Year 2012 United States Air Force Agency Financial Report

DTIC Science & Technology

2012-01-01

Air Force Research Laboratory (AFRL) and Lawrence Livermore National Laboratory (LLNL) aggressively designed and tested an advanced warhead to...Reaper procurement & RPA capabilities, Light Attack Armed Reconnaissance buys, Joint Strike Fighter, satellites). Research , Development, Test and...Military Personnel Operations, Readiness & Support Procurement Research , Development, Test & Evaluation

Media effects of experimental presentation of the ideal physique on eating disorder symptoms: a meta-analysis of laboratory studies.

PubMed

Hausenblas, Heather A; Campbell, Anna; Menzel, Jessie E; Doughty, Jessica; Levine, Michael; Thompson, J Kevin

2013-02-01

Older meta-analyses of the effects of the media's portrayal of the ideal physique have found small effects revealing that exposure to the ideal physique increases body image concerns. These meta-analyses also included correlational, quasi-experimental, and experimental studies, with limited examination of moderators and other relevant outcomes besides body image. We conducted a systematic literature search and identified 33 experimental (i.e., pre and post data for both experimental and control groups) laboratory studies examining the effects of acute exposure to the media's portrayal of the ideal physique on eating disorder symptoms (i.e., body image, positive affect, negative affect, self-esteem, anger, anxiety and depression) and the mechanisms that moderate this effect. Fourteen separate meta-analyses revealed a range of small to moderate effect sizes for change in outcomes from pre to post for both experimental and control groups. Exposure to images of the ideal physique resulted in small effect sizes for increased depression and anger and decreased self-esteem and positive affect. Moderator analyses revealed moderate effect sizes for increased depression and body dissatisfaction among high-risk participants. This meta-analysis makes it clear that media exposure of the ideal physique results in small changes in eating disorder symptoms, particularly with participants at high risk for developing an eating disorder. Further research is needed to examine the longitudinal effects of media exposure of eating disorder symptoms. Copyright © 2012 Elsevier Ltd. All rights reserved.

The aesthetics of laboratory inscription: Claude Bernard's Cahier Rouge.

PubMed

Sattar, Atia

2013-03-01

This essay explores the aesthetic sensibilities of the French physiologist Claude Bernard (1813-1878). In particular, it analyzes the Cahier Rouge (1850-1860), Bernard's acclaimed laboratory notebook. In this notebook, Bernard articulates the range of his experience as an experimental physiologist, juxtaposing without differentiation details of laboratory procedure and more personal queries, doubts, and reflections on experimentation, life, and art. Bernard's insights, it is argued, offer an aesthetic and phenomenological template for considering experimentation. His physiological point of view ranges from his own bodily aesthesis or sensory perception, through personal reflections on scientific discovery as an artistic process, to a broader metaphysical conception of life as an artistic creation. Such an aesthetic approach to physiology enables Bernard to reconcile his empirical methodology and his romantic idealism; it offers the history of laboratory science a framework for considering the individual, bodily, and emotional labor inherent in physiological experimentation.

Enhanced verification test suite for physics simulation codes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kamm, James R.; Brock, Jerry S.; Brandon, Scott T.

2008-09-01

This document discusses problems with which to augment, in quantity and in quality, the existing tri-laboratory suite of verification problems used by Los Alamos National Laboratory (LANL), Lawrence Livermore National Laboratory (LLNL), and Sandia National Laboratories (SNL). The purpose of verification analysis is demonstrate whether the numerical results of the discretization algorithms in physics and engineering simulation codes provide correct solutions of the corresponding continuum equations.

Multiple Experimental Platform Consistency at NIF

NASA Astrophysics Data System (ADS)

Benedetti, L. R.; Barrios, M. A.; Bradley, D. K.; Eder, D. C.; Khan, S. F.; Izumi, N.; Jones, O. S.; Ma, T.; Nagel, S. R.; Peterson, J. L.; Rygg, J. R.; Spears, B. K.; Town, R. P.

2013-10-01

ICF experiments at NIF utilize several platforms to assess different metrics of implosion quality. In addition to the point design-a target capsule of DT ice inside a thin plastic ablator-notable platforms include: (i) Symmetry Capsules(SymCaps), mass-adjusted CH capsules filled with DT gas for similar hydrodynamic performance without the need for a DT crystal; (ii) D:3He filled SymCaps, designed for low neutron yield implosions to accommodate a variety of x-ray and optical diagnostics; and (iii) Convergent Ablators, SymCaps coupled with x-radiography to assess in-flight velocity and symmetry of the implosion over ~1 ns before stagnation and burn. These platforms are expected to be good surrogates for one another, and their hohlraum and implosion performance variations have been simulated in detail. By comparing results of similar experiments, we isolate platform-specific variations. We focus on the symmetry, convergence, and timing of x-ray emission as observed in each platform as this can be used to infer stagnation pressure and temperature. This work performed under the auspices of the U.S. Dept. of Energy by LLNL under Contract DE-AC52-07NA27344. LLNL-ABS-640865.

Students' Assessment of Interactive Distance Experimentation in Nuclear Reactor Physics Laboratory Education

ERIC Educational Resources Information Center

Malkawi, Salaheddin; Al-Araidah, Omar

2013-01-01

Laboratory experiments develop students' skills in dealing with laboratory instruments and physical processes with the objective of reinforcing the understanding of the investigated subject. In nuclear engineering, where research reactors play a vital role in the practical education of students, the high cost and long construction time of research…

An Inquiry-Based Density Laboratory for Teaching Experimental Error

ERIC Educational Resources Information Center

Prilliman, Stephen G.

2012-01-01

An inquiry-based laboratory exercise is described in which introductory chemistry students measure the density of water five times using either a beaker, a graduated cylinder, or a volumetric pipet. Students are also assigned to use one of two analytical balances, one of which is purposefully miscalibrated by 5%. Each group collects data using…

Participation of Bell Telephone Laboratories in Project Echo and Experimental Results

NASA Technical Reports Server (NTRS)

Jakes, William C., Jr.

1961-01-01

On August 12, 1960, Echo I, a 100-foot-diameter spherical balloon, was placed in orbit around the earth by the National Aeronautics and Space Administration. The objective was to demonstrate the feasibility of long-distance communication by microwave reflection from a satellite. A two-way coast-to-coast voice circuit was to be established between the Jet Propulsion Laboratory (JPL) facility in California and a station provided by Bell Telephone Laboratories (STL) in New Jersey. Similar tests were also planned with the Naval Research Laboratory and other stations. This paper describes the general organization and operation of the Holmdel, New Jersey, station, and discusses the results of the experiments performed between the balloon launching and March 1, 1961. Successful voice communication was achieved through a variety of modulation methods including frequency modulation with feedback, amplitude modulation, single-sideband modulation, and narrow-band phase modulation. Careful measurements were also made of the loss in the transmission path.

Laboratory Experimental Design for a Glycomic Study.

PubMed

Ugrina, Ivo; Campbell, Harry; Vučković, Frano

2017-01-01

Proper attention to study design before, careful conduct of procedures during, and appropriate inference from results after scientific experiments are important in all scientific studies in order to ensure valid and sometimes definitive conclusions can be made. The design of experiments, also called experimental design, addresses the challenge of structuring and conducting experiments to answer the questions of interest as clearly and efficiently as possible.

Experimental macroevolution†

PubMed Central

Bell, Graham

2016-01-01

The convergence of several disparate research programmes raises the possibility that the long-term evolutionary processes of innovation and radiation may become amenable to laboratory experimentation. Ancestors might be resurrected directly from naturally stored propagules or tissues, or indirectly from the expression of ancestral genes in contemporary genomes. New kinds of organisms might be evolved through artificial selection of major developmental genes. Adaptive radiation can be studied by mimicking major ecological transitions in the laboratory. All of these possibilities are subject to severe quantitative and qualitative limitations. In some cases, however, laboratory experiments may be capable of illuminating the processes responsible for the evolution of new kinds of organisms. PMID:26763705

Micromachined probes for laboratory plasmas

NASA Astrophysics Data System (ADS)

Chiang, Franklin Changta

As we begin to find more applications for plasmas in our everyday lives, the ability to characterize and understand their inner workings becomes increasingly important. Much of our current understanding of plasma physics comes from investigations conducted in diffuse, outer space plasmas where experimenters have no control over the environment or experimental conditions and one measures interesting phenomena only by chance when the spacecraft or satellite passes through them. Ideally, experiments should be performed in a controlled environment, where plasma events can be deliberately and reliably created when wanted and probes placed precisely within the plasma. Unfortunately, often due to their size, probes used in outer space are unsuitable for use in high-density laboratory plasmas, and constructing probes that can be used in terrestrial plasmas is a considerable challenge. This dissertation presents the development, implementation, and experimental results of three micromachined probes capable of measuring voltage and electric field, ion energies, and changing magnetic fields (B-dot) in laboratory plasmas.

Laboratory Based Case Studies: Closer to the Real World

ERIC Educational Resources Information Center

Dinan, Frank J.

2005-01-01

Case-based laboratories offer students the chance to approximate real science. Based on interesting stories that pose problems requiring experimental solutions, they avoid the cookbook approach characteristic of traditional undergraduate laboratory instruction. Instead, case-based laboratories challenge students to develop, as much as possible,…

Laboratory-based Interpretation of Seismological Models: Dealing with Incomplete or Incompatible Experimental Data (Invited)

NASA Astrophysics Data System (ADS)

Jackson, I.; Kennett, B. L.; Faul, U. H.

2009-12-01

In parallel with cooperative developments in seismology during the past 25 years, there have been phenomenal advances in mineral/rock physics making laboratory-based interpretation of seismological models increasingly useful. However, the assimilation of diverse experimental data into a physically sound framework for seismological application is not without its challenges as demonstrated by two examples. In the first example, that of equation-of-state and elasticity data, an appropriate, thermodynamically consistent framework involves finite-strain expansion of the Helmholz free energy incorporating the Debye approximation to the lattice vibrational energy, as advocated by Stixrude and Lithgow-Bertelloni. Within this context, pressure, specific heat and entropy, thermal expansion, elastic constants and their adiabatic and isothermal pressure derivatives are all calculable without further approximation in an internally consistent manner. The opportunities and challenges of assimilating a wide range of sometimes marginally incompatible experimental data into a single model of this type will be demonstrated with reference to MgO, unquestionably the most thoroughly studied mantle mineral. A neighbourhood-algorithm inversion has identified a broadly satisfactory model, but uncertainties in key parameters associated particularly with pressure calibration remain sufficiently large as to preclude definitive conclusions concerning lower-mantle chemical composition and departures from adiabaticity. The second example is the much less complete dataset concerning seismic-wave dispersion and attenuation emerging from low-frequency forced-oscillation experiments. Significant progress has been made during the past decade towards an understanding of high-temperature, micro-strain viscoelastic relaxation in upper-mantle materials, especially as regards the roles of oscillation period, temperature, grain size and melt fraction. However, the influence of other potentially important

Physics Laboratory in UEC

NASA Astrophysics Data System (ADS)

Takada, Tohru; Nakamura, Jin; Suzuki, Masaru

All the first-year students in the University of Electro-Communications (UEC) take "Basic Physics I", "Basic Physics II" and "Physics Laboratory" as required subjects; Basic Physics I and Basic Physics II are calculus-based physics of mechanics, wave and oscillation, thermal physics and electromagnetics. Physics Laboratory is designed mainly aiming at learning the skill of basic experimental technique and technical writing. Although 95% students have taken physics in the senior high school, they poorly understand it by connecting with experience, and it is difficult to learn Physics Laboratory in the university. For this reason, we introduced two ICT (Information and Communication Technology) systems of Physics Laboratory to support students'learning and staff's teaching. By using quantitative data obtained from the ICT systems, we can easily check understanding of physics contents in students, and can improve physics education.

Summary Report of Ecological Risk Assessment for the Operation of the Explosives Waste Treatment Facility at Site 300 of the Lawrence Livermore National Laboratory.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gallegos, Gretchen M.; Terusaki, Stan H.

2013-12-01

An ecological risk assessment is required as part of the Resource Recovery and Conservation Act (RCRA) permit renewal process for Miscellaneous Units subject to 22 CCR 66270.23. This risk assessment is prepared in support of the RCRA permit renewal for the Explosives Waste Treatment Facility (EWTF) at Site 300 of the Lawrence Livermore National Laboratory (LLNL). LLNL collected soil samples and used the resulting data to produce a scoping-level ecological risk assessment pursuant to the Department of Toxic Substances Control, Guidance for Ecological Risk Assessment at Hazardous Waste Sites and Permitted Facilities, Part A: Overview, July 4, 1996. The scoping-levelmore » ecological risk assessment provides a framework to determine the potential interaction between ecological receptors and chemicals of concern from hazardous waste treatment operations in the area of EWTF. A scoping-level ecological risk assessment includes the step of conducting soil sampling in the area of the treatment units. The Sampling Plan in Support of the Human Health and Ecological Risk Assessment for the Operation of the Explosives Waste Treatment Facility at Site 300 of the Lawrence Livermore National Laboratory, (Terusaki, 2007), outlines the EWTF project-specific soil sampling requirements. Soil samples were obtained and analyzed for constituents from four chemical groups: furans, explosives, semi-volatiles and metals. Analytical results showed that furans, explosives and semi-volatiles were not detected; therefore, no further analysis was conducted. The soil samples did show the presence of metals. Soil samples analyzed for metals were compared to site-wide background levels, which had been developed for site -wide cleanup activities pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). Total metal concentrations from 28 discrete soil samples obtained in the EWTF area were all below CERCLA-developed background levels. Therefore, following DTSC

Results of Surveys for Special Status Reptiles at the Site 300 Facilities of Lawrence Livermore National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Woollett, J J

2008-09-18

The purpose of this report is to present the results of a live-trapping and visual surveys for special status reptiles at the Site 300 Facilities of Lawrence Livermore National Laboratory (LLNL). The survey was conducted under the authority of the Federal recovery permit of Swaim Biological Consulting (PRT-815537) and a Memorandum of Understanding issued from the California Department of Fish and Game. Site 300 is located between Livermore and Tracy just north of Tesla road (Alameda County) and Corral Hollow Road (San Joaquin County) and straddles the Alameda and San Joaquin County line (Figures 1 and 2). It encompasses portionsmore » of the USGS 7.5 minute Midway and Tracy quadrangles (Figure 2). Focused surveys were conducted for four special status reptiles including the Alameda whipsnake (Masticophis lateralis euryxanthus), the San Joaquin Whipsnake (Masticophis Hagellum ruddock), the silvery legless lizard (Anniella pulchra pulchra), and the California horned lizard (Phrynosoma coronanum frontale).« less

Experiments and simulations of Richtmyer-Meshkov Instability with measured,volumetric initial conditions

NASA Astrophysics Data System (ADS)

Sewell, Everest; Ferguson, Kevin; Jacobs, Jeffrey; Greenough, Jeff; Krivets, Vitaliy

2016-11-01

We describe experiments of single-shock Richtmyer-Meskhov Instability (RMI) performed on the shock tube apparatus at the University of Arizona in which the initial conditions are volumetrically imaged prior to shock wave arrival. Initial perturbations play a major role in the evolution of RMI, and previous experimental efforts only capture a single plane of the initial condition. The method presented uses a rastered laser sheet to capture additional images throughout the depth of the initial condition immediately before the shock arrival time. These images are then used to reconstruct a volumetric approximation of the experimental perturbation. Analysis of the initial perturbations is performed, and then used as initial conditions in simulations using the hydrodynamics code ARES, developed at Lawrence Livermore National Laboratory (LLNL). Experiments are presented and comparisons are made with simulation results.

Laboratory Design for Microbiological Safety

PubMed Central

Phillips, G. Briggs; Runkle, Robert S.

1967-01-01

Of the large amount of funds spent each year in this country on construction and remodeling of biomedical research facilities, a significant portion is directed to laboratories handling infectious microorganisms. This paper is intended for the scientific administrators, architects, and engineers concerned with the design of new microbiological facilities. It develops and explains the concept of primary and secondary barriers for the containment of microorganisms. The basic objectives of a microbiological research laboratory, (i) protection of the experimenter and staff, (ii) protection of the surrounding community, and (iii) maintenance of experimental validity, are defined. In the design of a new infectious-disease research laboratory, early identification should be made of the five functional zones of the facility and their relation to each other. The following five zones and design criteria applicable to each are discussed: clean and transition, research area, animal holding and research area, laboratory support, engineering support. The magnitude of equipment and design criteria which are necessary to integrate these five zones into an efficient and safe facility are delineated. Images Fig. 1 Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7 Fig. 8 Fig. 9 Fig. 10 Fig. 11 Fig. 12 Fig. 13 Fig. 14 Fig. 15 Fig. 16 Fig. 17 Fig. 18 Fig. 19 PMID:4961771

The CGE-PLATO Electronic Laboratory Station Structure and Operation.

ERIC Educational Resources Information Center

Neal, J. P.

An electronic laboratory station was designed for student use in learning electronic instrumentation and measurement by means of the computer-guided experimentation (CGE) system. The station features rack-mounted electronic laboratory equipment on a laboratory table adjacent to a PLATO IV terminal. An integrated logic system behind the laboratory…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernhardt, A. F.; Smith, P. M.

This project was a collaborative effort between the University of California, Lawrence Livermore National Laboratory (LLNL) and FlexICs, Inc. to develop thin film transistor (TFT) electronics for active matrix displays.

Radon measurements in the Gran Sasso Underground Laboratory.

PubMed

Arpesella, C; Bam, B B; Bassignani, A; Cecchini, S; Colombo, G; Dekhissi, H; Fresca Fantoni, R; Giacomelli, G; Lembo, L; Maltoni, G; Mandrioli, G; Patrizii, L; Sartorio, C; Serra, P; Togo, V; Vilela, E

1997-04-01

Systematic radon monitoring in the Gran Sasso Underground Laboratory was performed in order to determine the background radon contribution to the sophisticated experimental apparatus and to check health physics standards for the personnel. As expected, the radon concentrations were found to depend strongly on the ventilation in the three experimental halls. Considerable reductions in the radon concentrations were obtained in 1993, when fresh air was drawn into the laboratory through a pipe and exhaust air was routed into the highway tunnel.

An open microcomputer-based laboratory system for perceptional experimentality

NASA Astrophysics Data System (ADS)

Hamalainen, Ari

A computer, equipped with hardware for acquiring data about the properties of a physical system and programs for processing that data, is a powerful tool for physics research and instruction. There is strong evidence that utilizing microcomputer-based laboratories (MBLs) in instruction can lead to significantly improved learning. The perceptional approach is a method for physics instruction, developed at the Department of Physics, University of Helsinki. Its main arguments are that the meanings of the concepts must be learnt before their formal definitions and adoption, and that learning and research are fundamentally similar concept formation processes. Applying the perceptional approach requires the ability to perform quantitative experiments, either as students' laboratory exercises or as lecture demonstrations, and to process their results. MBL tools are essential for this. In student's laboratory exercises, they reduce the routine work and leave more time for the actual learning. In lecture demonstrations, they make it possible to perform the experiments in the tight time limits. At a previous stage of the research, a set of requirements was found that the perceptional approach places on MBL systems. The primary goal of this thesis is to build a prototype of a MBL system that would fulfil these requirements. A secondary goal is to describe technical aspects of a computerized measurement system from the standpoint of educational use. The prototype was built using mostly commercial sensors and data acquisition units. The software was written with a visual programming language, designed for instrumentation applications. The prototype system was developed and tested with a set of demonstrations of various topics in the Finnish high school physics curriculum, which were implemented according to the perceptional approach. Limited usability tests were also performed. The prototype was improved, until it could perform the test demonstrations. It was found to meet the

Small Optics Laser Damage Test Procedure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolfe, Justin

2017-10-19

This specification defines the requirements and procedure for laser damage testing of coatings and bare surfaces designated for small optics in the National Ignition Facility (NIF) at Lawrence Livermore National Laboratory (LLNL).

Final closure plan for the high-explosives open burn treatment facility at Lawrence Livermore National Laboratory Experimental Test Site 300

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mathews, S.

This document addresses the interim status closure of the HE Open Bum Treatment Facility, as detailed by Title 22, Division 4.5, Chapter 15, Article 7 of the Califonia Code of Regulations (CCR) and by Title 40, Code of Federal Regulations (CFR) Part 265, Subpart G, ``Closure and Post Closure.`` The Closure Plan (Chapter 1) and the Post- Closure Plan (Chapter 2) address the concept of long-term hazard elimination. The Closure Plan provides for capping and grading the HE Open Bum Treatment Facility and revegetating the immediate area in accordance with applicable requirements. The Closure Plan also reflects careful consideration ofmore » site location and topography, geologic and hydrologic factors, climate, cover characteristics, type and amount of wastes, and the potential for contaminant migration. The Post-Closure Plan is designed to allow LLNL to monitor the movement, if any, of pollutants from the treatment area. In addition, quarterly inspections will ensure that all surfaces of the closed facility, including the cover and diversion ditches, remain in good repair, thus precluding the potential for contaminant migration.« less

ATTEMPTS TO ESTABLISH EXPERIMENTAL CYCLOSPORA CAYETANENSIS INFECTION IN LABORATORY ANIMALS

EPA Science Inventory

Attempts were made to develop an animal model for Cyclospora cayetanensis to identify a practical laboratory host for studying human cyclosporiasis. Oocysts collected from stool of infected humans in the United States, Haiti, Guatemala, Peru and Nepal were held in potassium dich...

ATTEMPS TO ESTABLISH EXPERIMENTAL CYCLOSPORA CAYETANENSIS INFECTION IN LABORATORY ANIMALS

EPA Science Inventory

Attemps were made to develop an animal model for Cyclospora cayetanensis to identify a practical laboratory host for studing human cyclosporiasis. Oocysts collected from stool of infected humans in the United States, Haiti, Guatemala, Peru, and Nepal were held in potassium dichro...

An evaluation of alternative reactor vessel cutting technologies for the experimental boiling water reactor at Argonne National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boing, L.E.; Henley, D.R.; Manion, W.J.

1989-12-01

Metal cutting techniques that can be used to segment the reactor pressure vessel of the Experimental Boiling Water Reactor (EBWR) at Argonne National Laboratory (ANL) have been evaluated by Nuclear Energy Services. Twelve cutting technologies are described in terms of their ability to perform the required task, their performance characteristics, environmental and radiological impacts, and cost and schedule considerations. Specific recommendations regarding which technology should ultimately be used by ANL are included. The selection of a cutting method was the responsibility of the decommissioning staff at ANL, who included a relative weighting of the parameters described in this document inmore » their evaluation process. 73 refs., 26 figs., 69 tabs.« less

An Archive of Downscaled WCRP CMIP3 Climate Projections for Planning Applications in the Contiguous United States

NASA Astrophysics Data System (ADS)

Brekke, L. D.; Pruitt, T.; Maurer, E. P.; Duffy, P. B.

2007-12-01

Incorporating climate change information into long-term evaluations of water and energy resources requires analysts to have access to climate projection data that have been spatially downscaled to "basin-relevant" resolution. This is necessary in order to develop system-specific hydrology and demand scenarios consistent with projected climate scenarios. Analysts currently have access to "climate model" resolution data (e.g., at LLNL PCMDI), but not spatially downscaled translations of these datasets. Motivated by a common interest in supporting regional and local assessments, the U.S. Bureau of Reclamation and LLNL (through support from the DOE National Energy Technology Laboratory) have teamed to develop an archive of downscaled climate projections (temperature and precipitation) with geographic coverage consistent with the North American Land Data Assimilation System domain, encompassing the contiguous United States. A web-based information service, hosted at LLNL Green Data Oasis, has been developed to provide Reclamation, LLNL, and other interested analysts free access to archive content. A contemporary statistical method was used to bias-correct and spatially disaggregate projection datasets, and was applied to 112 projections included in the WCRP CMIP3 multi-model dataset hosted by LLNL PCMDI (i.e. 16 GCMs and their multiple simulations of SRES A2, A1b, and B1 emissions pathways).

Interventional Application of Shape Memory Polymer Foam Final Report CRADA No. TC-02067-03

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maitland, D.; Metzger, M. F.

This was a collaborative effort between The Regents of the University of California, Lawrence Livermore National Laboratory (LLNL) and Sierra Interventions, LLC, to develop shape memory polymer foam devices for treating hemorrhagic stroke.

Requirements Doc for Refurb of JASPER Facility in B131HB

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knittel, Kenn M.

The Joint Actinide Shock Physics Experimental Research (JASPER) Program target fabrication facility is currently located in building 131 (B131) of the Lawrence Livermore National Laboratory (LLNL). A portion of this current facility has been committed to another program as part of a larger effort to consolidate LLNL capabilities into newer facilities. This facility assembles precision targets for scientific studies at the Nevada National Security Site (NNSS). B131 is also going through a modernization project to upgrade the infrastructure and abate asbestos. These activities will interrupt the continuous target fabrication efforts for the JASPER Program. Several options are explored to meetmore » the above conflicting requirements, with the final recommendation to prepare a new facility for JASPER target fabrication operations before modernization efforts begin in the current facility assigned to JASPER. This recommendation fits within all schedule constraints and minimizes the disruption to the JASPER Program. This option is not without risk, as it requires moving an aged, precision coordinate measuring machine, which is essential to the JASPER Program’s success. The selected option balances the risk to the machine with continuity of operations.« less

Modern Chemistry Techniques Applied to Metal Behavior and Chelation in Medical and Environmental Systems ? Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sutton, M; Andresen, B; Burastero, S R

2005-02-03

This report details the research and findings generated over the course of a 3-year research project funded by Lawrence Livermore National Laboratory (LLNL) Laboratory Directed Research and Development (LDRD). Originally tasked with studying beryllium chemistry and chelation for the treatment of Chronic Beryllium Disease and environmental remediation of beryllium-contaminated environments, this work has yielded results in beryllium and uranium solubility and speciation associated with toxicology; specific and effective chelation agents for beryllium, capable of lowering beryllium tissue burden and increasing urinary excretion in mice, and dissolution of beryllium contamination at LLNL Site 300; {sup 9}Be NMR studies previously unstudied atmore » LLNL; secondary ionization mass spec (SIMS) imaging of beryllium in spleen and lung tissue; beryllium interactions with aerogel/GAC material for environmental cleanup. The results show that chelator development using modern chemical techniques such as chemical thermodynamic modeling, was successful in identifying and utilizing tried and tested beryllium chelators for use in medical and environmental scenarios. Additionally, a study of uranium speciation in simulated biological fluids identified uranium species present in urine, gastric juice, pancreatic fluid, airway surface fluid, simulated lung fluid, bile, saliva, plasma, interstitial fluid and intracellular fluid.« less

Development of Diagnostics for the Livermore DPF Devices

NASA Astrophysics Data System (ADS)

Mitrani, James; Prasad, Rahul R.; Podpaly, Yuri A.; Cooper, Christopher M.; Chapman, Steven F.; Shaw, Brian H.; Povilus, Alexander P.; Schmidt, Andrea

2017-10-01

LLNL is commissioning several new diagnostics to understand and optimize ion and neutron production in their dense plasma focus (DPF) systems. Gas fills used in DPF devices at LLNL are Deuterium (D2) and He accelerated onto a Be target, for production of neutrons. Neutron yields are currently measured with Helium-3 tubes, and development of yttrium-based activation detectors is currently underway. Neutron time-of-flight (nTOF) signals from prompt neutrons will be measured with gadolinium-doped liquid scintillators. An ion energy analyzer will be used to diagnose energy distribution of D + and He +2 ions. Additionally, a fast frame ICCD camera has been applied to image the plasma sheath during the rundown and pinch phases. Sheath velocity will be measured with an array of discrete photodiodes with ns time responses. A discussion of our results will be presented. Prepared by LLNL under Contract DE-AC52-07NA27344, and supported by the Laboratory Directed Research and Development Program (15-ERD-034) at LLNL and the Office of Defense Nuclear Nonproliferation Research and Development within U.S. Department of Energy.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peck, T; Sparkman, D; Storch, N

''The LLNL Site-Specific Advanced Simulation and Computing (ASCI) Software Quality Engineering Recommended Practices VI.I'' document describes a set of recommended software quality engineering (SQE) practices for ASCI code projects at Lawrence Livermore National Laboratory (LLNL). In this context, SQE is defined as the process of building quality into software products by applying the appropriate guiding principles and management practices. Continual code improvement and ongoing process improvement are expected benefits. Certain practices are recommended, although projects may select the specific activities they wish to improve, and the appropriate time lines for such actions. Additionally, projects can rely on the guidance ofmore » this document when generating ASCI Verification and Validation (VSrV) deliverables. ASCI program managers will gather information about their software engineering practices and improvement. This information can be shared to leverage the best SQE practices among development organizations. It will further be used to ensure the currency and vitality of the recommended practices. This Overview is intended to provide basic information to the LLNL ASCI software management and development staff from the ''LLNL Site-Specific ASCI Software Quality Engineering Recommended Practices VI.I'' document. Additionally the Overview provides steps to using the ''LLNL Site-Specific ASCI Software Quality Engineering Recommended Practices VI.I'' document. For definitions of terminology and acronyms, refer to the Glossary and Acronyms sections in the ''LLNL Site-Specific ASCI Software Quality Engineering Recommended Practices VI.I''.« less

Inertial Fusion and High-Energy-Density Science in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tarter, C B

2001-09-06

Inertial fusion and high-energy density science worldwide is poised to take a great leap forward. In the US, programs at the University of Rochester, Sandia National Laboratories, Los Alamos National Laboratory, Lawrence Livermore National Laboratory (LLNL), the Naval Research Laboratory, and many smaller laboratories have laid the groundwork for building a facility in which fusion ignition can be studied in the laboratory for the first time. The National Ignition Facility (NIF) is being built by the Department of Energy's National Nuclear Security Agency to provide an experimental test bed for the US Stockpile Stewardship Program (SSP) to ensure the dependabilitymore » of the country's nuclear deterrent without underground nuclear testing. NIF and other large laser systems being planned such as the Laser MegaJoule (LMJ) in France will also make important contributions to basic science, the development of inertial fusion energy, and other scientific and technological endeavors. NIF will be able to produce extreme temperatures and pressures in matter. This will allow simulating astrophysical phenomena (on a tiny scale) and measuring the equation of state of material under conditions that exist in planetary cores.« less

Measurement of the ^235mU Production Cross Section Using a Critical Assembly*

NASA Astrophysics Data System (ADS)

Macri, Robert; Authier, Nicolas; Becker, John; Belier, Gilbert; Bond, Evelyn; Bredeweg, Todd; Glover, S.; Meot, Vincent; Rundberg, Robert; Vieira, David; Wilhelmy, Jerry

2006-10-01

Measurements of the creation and destruction cross sections for actinide nuclei constitute an important experimental effort in support of Stockpile Stewardship. In this talk I will give a progress report on the effort to measure the production cross section of the ^235mU isomer integrated over a fission neutron spectrum. This ongoing experiment is fielded at CEA in Valduc, France, taking advantage of the CALIBAN critical assembly. This effort is performed in collaboration with LANL, LLNL, Bruyeres le Chatel, and Valduc staff. This experiment utilizes a technique to measure internal conversion electrons from the ^235mU isomer with the French BIII detector (Bruyeres le Chatel), and involves a substantial chemistry effort (LANL) to prepare targets for irradiation and counting, as well as to remove fission fragments after irradiation. Experimental techniques will be discussed and preliminary data presented. *Work performed under the auspices of the U.S. Department of Energy by Los Alamos National Laboratory (W-7405-ENG-36) and Lawrence Livermore National Laboratory (W-7405-ENG-48), and CEA-DAM under CEA-DAM NNSA-DOE agreement.

Institute of Geophyics and Planetary Physics. Annual report for FY 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ryerson, F.J.

1995-09-29

The Institute of Geophysics and Planetary Physics (IGPP) is a Multicampus Research Unit of the University of California (UC). IGPP was founded in 1946 at UC Los Angeles with a charter to further research in the earth and planetary sciences and in related fields. The Institute now has branches at UC campuses in Los Angeles, San Diego, Riverside, and Irvine and at Los Alamos and Lawrence Livermore national laboratories. The University-wide IGPP has played an important role in establishing interdisciplinary research in the earth and planetary sciences. For example, IGPP was instrumental in founding the fields of physical oceanography andmore » space physics, which at the time fell between the cracks of established university departments. Because of its multicampus orientation, IGPP has sponsored important interinstitutional consortia in the earth and planetary sciences. Each of the six branches has a somewhat different intellectual emphasis as a result of the interplay between strengths of campus departments and Laboratory programs. The IGPP branch at Lawrence Livermore National Laboratory (LLNL) was approved by the Regents of the University of California in 1982. IGPP-LLNL emphasizes research in seismology, geochemistry, cosmochemistry, high-pressure sciences, and astrophysics. It provides a venue for studying the fundamental aspects of these fields, thereby complementing LLNL programs that pursue applications of these disciplines in national security and energy research. IGPP-LLNL is directed by Charles Alcock and is structured around three research centers. The Center for Geosciences, headed by George Zandt and Frederick Ryerson, focuses on research in geophysics and geochemistry. The Center for High-Pressure Sciences, headed by William Nellis, sponsors research on the properties of planetary materials and on the synthesis and preparation of new materials using high-pressure processing.« less

Modernisation of the intermediate physics laboratory

NASA Astrophysics Data System (ADS)

Kontro, Inkeri; Heino, Olga; Hendolin, Ilkka; Galambosi, Szabolcs

2018-03-01

The intermediate laboratory courses at the Department of Physics, University of Helsinki, were reformed using desired learning outcomes as the basis for design. The reformed laboratory courses consist of weekly workshops and small-group laboratory sessions. Many of the laboratory exercises are open-ended and have several possible ways of execution. They were designed around affordable devices, to allow for the purchase of multiple sets of laboratory equipment. This allowed students to work on the same problems simultaneously. Thus, it was possible to set learning goals which build on each other. Workshop sessions supported the course by letting the students solve problems related to conceptual and technical aspects of each laboratory exercise. The laboratory exercises progressed biweekly to allow for iterative problem solving. Students reached the learning goals well and the reform improved student experiences. Neither positive or negative changes in expert-like attitudes towards experimental physics (measured by E-CLASS questionnaire) were observed.

Laboratory space physics: Investigating the physics of space plasmas in the laboratory

NASA Astrophysics Data System (ADS)

Howes, Gregory G.

2018-05-01

Laboratory experiments provide a valuable complement to explore the fundamental physics of space plasmas without the limitations inherent to spacecraft measurements. Specifically, experiments overcome the restriction that spacecraft measurements are made at only one (or a few) points in space, enable greater control of the plasma conditions and applied perturbations, can be reproducible, and are orders of magnitude less expensive than launching spacecraft. Here, I highlight key open questions about the physics of space plasmas and identify the aspects of these problems that can potentially be tackled in laboratory experiments. Several past successes in laboratory space physics provide concrete examples of how complementary experiments can contribute to our understanding of physical processes at play in the solar corona, solar wind, planetary magnetospheres, and the outer boundary of the heliosphere. I present developments on the horizon of laboratory space physics, identifying velocity space as a key new frontier, highlighting new and enhanced experimental facilities, and showcasing anticipated developments to produce improved diagnostics and innovative analysis methods. A strategy for future laboratory space physics investigations will be outlined, with explicit connections to specific fundamental plasma phenomena of interest.

2011 Computation Directorate Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crawford, D L

2012-04-11

From its founding in 1952 until today, Lawrence Livermore National Laboratory (LLNL) has made significant strategic investments to develop high performance computing (HPC) and its application to national security and basic science. Now, 60 years later, the Computation Directorate and its myriad resources and capabilities have become a key enabler for LLNL programs and an integral part of the effort to support our nation's nuclear deterrent and, more broadly, national security. In addition, the technological innovation HPC makes possible is seen as vital to the nation's economic vitality. LLNL, along with other national laboratories, is working to make supercomputing capabilitiesmore » and expertise available to industry to boost the nation's global competitiveness. LLNL is on the brink of an exciting milestone with the 2012 deployment of Sequoia, the National Nuclear Security Administration's (NNSA's) 20-petaFLOP/s resource that will apply uncertainty quantification to weapons science. Sequoia will bring LLNL's total computing power to more than 23 petaFLOP/s-all brought to bear on basic science and national security needs. The computing systems at LLNL provide game-changing capabilities. Sequoia and other next-generation platforms will enable predictive simulation in the coming decade and leverage industry trends, such as massively parallel and multicore processors, to run petascale applications. Efficient petascale computing necessitates refining accuracy in materials property data, improving models for known physical processes, identifying and then modeling for missing physics, quantifying uncertainty, and enhancing the performance of complex models and algorithms in macroscale simulation codes. Nearly 15 years ago, NNSA's Accelerated Strategic Computing Initiative (ASCI), now called the Advanced Simulation and Computing (ASC) Program, was the critical element needed to shift from test-based confidence to science-based confidence. Specifically, ASCI

Laboratory Techniques for the Blind

ERIC Educational Resources Information Center

Tombaugh, Dorothy

1972-01-01

Describes modifications of laboratory procedures for the BSCS Green Version biology, including dissection, microbiology, animal behavior, physiology, biochemistry, and genetics that make the methods suitable for direct experimentation by blind students. Discusses models as substitutes for microscopy. (AL)

[The experimental surgery and your relation with the university: an experience report].

PubMed

Yamaki, Vitor Nagai; Teixeira, Renan Kleber Costa; Feijo, Daniel Haber; Silva, José Antonio Cordero da; Botelho, Nara Macedo; Henriques, Marcus Vinicius

2014-01-01

The laboratory of experimental surgery represents one of the key points for the university, especially in the biomedical area. This focuses on the university's tripod of primary structure that are teaching, research and extension, which are essential for formation of humanistic and practice of a good doctor that is based, first of all, on scientific evidence and critical knowledge. The importance of a laboratory of experimental surgery centers for medical education was regulated from the new curriculum guidelines of the Ministério da Educação e Cultura, establishing a mandatory laboratory within college centers. Therefore, it is of great importance to the contribution of the laboratories of experimental surgery in the curriculum, both in the discipline of surgical technics and experimental surgery, and an incentive for basic research. Thus, the study presents the experience of 15 years of the Laboratory of Experimental Surgery from Universidade do Estado do Pará, with the goal show the importance of this to medical graduation and the university.

Development of a Commercial Prototype of the Autonomous Pathogen Detection System Final Report CRADA No. TC-02077-04

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dzenitis, J. M.; Haigh, P.

This was a collaborative effort between The Regents of the University of California, Lawrence Livermore National Laboratory (LLNL), and GE Ion Track, Inc. (GEIT) to develop a commercial prototype of the Autonomous Pathogen Detection System (APDS), an instrument that monitors the air for all three biological threat agents (bacteria, viruses and toxins). This was originally a one year CRADA project, with the cost of the work at LLNL being funded by the Department of Homeland Security's Office of National Laboratories. The original project consisted of five major tasks and deliverables. The CRADA was then amended, converting the CRADA from amore » programmatically funded CRADA to a funds-in CRADA, extending the project for an additional 14 months, and adding four new tasks and deliverable to the project.« less

2007 Annual Health Physics Report for the HEU Transparency Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Radev, R

2008-04-09

During the 2007 calendar year, Lawrence Livermore National Laboratory (LLNL) provided health physics support for the Highly Enriched Uranium (HEU) Transparency Program for external and internal radiation protection and technical expertise related to BDMS radioactive sources and Russian radiation safety regulatory compliance. For the calendar year 2007, there were 172 person-trips that required dose monitoring of the U.S. monitors. Of the 172 person-trips, 160 person-trips were SMVs and 12 person-trips were Transparency Monitoring Office (TMO) trips. There were 12 monitoring visits by TMO monitors to facilities other than UEIE and 10 to UEIE itself. There were two monitoring visits (sourcemore » changes) that were back to back with 14 monitors. LLNL's Hazard Control Division laboratories provided the dosimetry services for the HEU Transparency monitors.« less

Induction of a chronic myocardial infarction in the laboratory animal - experimental model

PubMed Central

POP, IONEL CIPRIAN; GRAD, NICOLAE-OVIDIU; PESTEAN, COSMIN; TAULESCU, MARIAN; MIRCEAN, MIRCEA; MIRONIUC, ION-AUREL

2013-01-01

Introduction Ischemic heart disease is a major public health problem in western countries. Appropriate animal experimental models of chronic myocardial infarction is an essential first step in order to investigate and develop new therapeutic interventions. Aim The aim of this study was to find an optimal place for a coronary artery ligation to induce an optimal chronic myocardial infarction and also a new heart approach that will not require oro-tracheal intubation. Material and methods To achieve these goals we used a group of rabbits and after induction of anesthesia and cardiac exposure by rib osteotomy (rib III, IV and V) at the costo-sternal junction level on the right side we performed three different left anterior descending artery (LAD) ligation at different distances (5, 10 and 15 mm) in relation to the apex. Thirty days after the acute myocardial infarction, we correlated laboratory investigations (serology, ECG, cardiac ultrasound) with histopathological findings. Results Heart approach achieved by rib osteotomy (rib III, IV and V) at the costo-sternal junction level on the right side, maintains the integrity of the ribcage, allowing it to take part in respiratory movements and the animal model does not need oro-tracheal intubation. Ligation of LAD at 15 mm from the apex was incompatible with life; ligation of LAD at 5 mm from the apex does not achieved transmural myocardial infarction and ligation of LAD at 10 mm from the apex achieved a transmural myocardial infarction of the left ventricle which also involved the distal part of the interventricular septum. Conclusion Ligation of LAD at 10 mm from the apex achieved a transmural myocardial infarction of the left ventricle, is in an easily accessible area from technical point of view, it is sufficiently expanded to induce hemodynamic effects that can be quantified with paraclinical examination and also it is compatible with the experimental animal life. If the heart is approached by rib III, IV and V

Module Architecture for in Situ Space Laboratories

NASA Technical Reports Server (NTRS)

Sherwood, Brent

2010-01-01

The paper analyzes internal outfitting architectures for space exploration laboratory modules. ISS laboratory architecture is examined as a baseline for comparison; applicable insights are derived. Laboratory functional programs are defined for seven planet-surface knowledge domains. Necessary and value-added departures from the ISS architecture standard are defined, and three sectional interior architecture options are assessed for practicality and potential performance. Contemporary guidelines for terrestrial analytical laboratory design are found to be applicable to the in-space functional program. Densepacked racks of system equipment, and high module volume packing ratios, should not be assumed as the default solution for exploration laboratories whose primary activities include un-scriptable investigations and experimentation on the system equipment itself.

Laboratory Measurements Of Charge-exchange Produced X-ray Emission From K-shell Transitions In Hydrogenic And Helium-like Fe

NASA Astrophysics Data System (ADS)

Brown, Gregory V.; Beiersdorfer, P.; Boyce, K. R.; Chen, H.; Gu, M. F.; Kelley, R. L.; Kilbourne, C. A.; Porter, F. S.; Thorn, D.; Wargelin, B.

2006-09-01

We have used a microcalorimeter and solid state detectors to measure x-ray emission produced by charge exchange reactions between bare and hydrogenic Fe colliding with neutral helium, hydrogen, and nitrogen gas. We show the measured spectral signature produced by different neutral donors and compare our results to theory where available. We also compare our results to measurements of the Fe K line emission from the Galactic Center measured by the XIS on the Suzaku x-ray observatory. This comparison shows that charge exchange recombination between highly charged ions (either cosmic rays or thermal ions) and neutral gas is probably not the dominant source of diffuse line emission in the Galactic Center. This work was performed under the auspices of the U.S. Department of Energy by University of California, Lawrence Livermore National Laboratory under Contract W-7405-Eng-48, and is also supported by NASA APRA grants to LLNL, GSFC, Harvard-Smithsonian CfA, and Stanford University.

Three-dimensional printing physiology laboratory technology.

PubMed

Sulkin, Matthew S; Widder, Emily; Shao, Connie; Holzem, Katherine M; Gloschat, Christopher; Gutbrod, Sarah R; Efimov, Igor R

2013-12-01

Since its inception in 19th-century Germany, the physiology laboratory has been a complex and expensive research enterprise involving experts in various fields of science and engineering. Physiology research has been critically dependent on cutting-edge technological support of mechanical, electrical, optical, and more recently computer engineers. Evolution of modern experimental equipment is constrained by lack of direct communication between the physiological community and industry producing this equipment. Fortunately, recent advances in open source technologies, including three-dimensional printing, open source hardware and software, present an exciting opportunity to bring the design and development of research instrumentation to the end user, i.e., life scientists. Here we provide an overview on how to develop customized, cost-effective experimental equipment for physiology laboratories.

Environmental Report 1996 Volume 2

DOT National Transportation Integrated Search

1997-09-01

This report, prepared by Lawrence Livermore National Laboratory (LLNL) for the U.S. Department of Energy, Oakland Operations Office (DOE/OAK), provides a comprehensive summary of the environmental program activities at Lawrence Livermore National Lab...

Environmental Report 1994

DOT National Transportation Integrated Search

1995-09-01

This report, prepared by Lawrence Livermore National Laboratory (LLNL) for the U.S. Department of Energy, Oakland Operations Office (DOE/OAK), provides a comprehensive summary of the environmental program activities at Lawrence Livermore National Lab...

Environmental Report 1996 Volume 1

DOT National Transportation Integrated Search

1997-09-01

This report, prepared by Lawrence Livermore National Laboratory (LLNL) for the U.S. Department of Energy, Oakland Operations Office (DOE/OAK), provides a comprehensive summary of the environmental program activities at Lawrence Livermore National Lab...

Environmental Report 1995

DOT National Transportation Integrated Search

1996-09-03

This report, prepared by Lawrence Livermore National Laboratory (LLNL) for the U.S. Department of Energy, Oakland Operations Office (DOE/OAK), provides a comprehensive summary of the environmental program activities at Lawrence Livermore National Lab...

Environmental Report 1993

DOT National Transportation Integrated Search

1994-09-01

This report, prepared by Lawrence Livermore National Laboratory (LLNL) for the U.S. Department of Energy, Oakland Operations Office (DOE/OAK), provides a comprehensive summary of the environmental program activities at Lawrence Livermore National Lab...

Environmental Report 1995, Volume 2

DOT National Transportation Integrated Search

1996-09-03

This report, prepared by Lawrence Livermore National Laboratory (LLNL) for the U.S. Department of Energy, Oakland Operations Office (DOE/OAK), provides a comprehensive summary of the environmental program activities at Lawrence Livermore National Lab...

Scientific biography, cognitive deficits, and laboratory practice. James McKeen Cattell and early American experimental psychology, 1880-1904.

PubMed

Sokal, Michael M

2010-09-01

Despite widespread interest in individual life histories, few biographies of scientists make use of insights derived from psychology, another discipline that studies people, their thoughts, and their actions. This essay argues that recent theoretical work in psychology and tools developed for clinical psychological practice can help biographical historians of science create and present fuller portraits of their subjects' characters and temperaments and more nuanced analyses of how these traits helped shape their subjects' scientific work. To illustrate this thesis, the essay examines the early career of James McKeen Cattell--an influential late nineteenth- and early twentieth-century experimental psychologist--through a lens offered by psychology and argues that Cattell's actual laboratory practices derived from an "accommodation" to a long-standing "cognitive deficit." These practices in turn enabled Cattell to achieve more precise experimental results than could any of his contemporaries; and their students readily adopted them, along with their behavioral implications. The essay concludes that, in some ways, American psychology's early twentieth-century move toward a behavioral understanding of psychological phenomena can be traced to Cattell's personal cognitive deficit. It closes by reviewing several "remaining general questions" that this thesis suggests.

Site 300 Spill Prevention, Control, and Countermeasures (SPCC) Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Griffin, D.; Mertesdorf, E.

This Spill Prevention, Control, and Countermeasure (SPCC) Plan describes the measures that are taken at Lawrence Livermore National Laboratory’s (LLNL) Experimental Test Site (Site 300) near Tracy, California, to prevent, control, and handle potential spills from aboveground containers that can contain 55 gallons or more of oil. This SPCC Plan complies with the Oil Pollution Prevention regulation in Title 40 of the Code of Federal Regulations, Part 112 (40 CFR 112) and with 40 CFR 761.65(b) and (c), which regulates the temporary storage of polychlorinated biphenyls (PCBs). This Plan has also been prepared in accordance with Division 20, Chapter 6.67more » of the California Health and Safety Code (HSC 6.67) requirements for oil pollution prevention (referred to as the Aboveground Petroleum Storage Act [APSA]), and the United States Department of Energy (DOE) Order No. 436.1. This SPCC Plan establishes procedures, methods, equipment, and other requirements to prevent the discharge of oil into or upon the navigable waters of the United States or adjoining shorelines for aboveground oil storage and use at Site 300. This SPCC Plan has been prepared for the entire Site 300 facility and replaces the three previous plans prepared for Site 300: LLNL SPCC for Electrical Substations Near Buildings 846 and 865 (LLNL 2015), LLNL SPCC for Building 883 (LLNL 2015), and LLNL SPCC for Building 801 (LLNL 2014).« less

Site 300 SPCC Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Griffin, D.

This Spill Prevention, Control, and Countermeasure (SPCC) Plan describes the measures that are taken at Lawrence Livermore National Laboratory’s (LLNL) Experimental Test Site (Site 300) near Tracy, California, to prevent, control, and handle potential spills from aboveground containers that can contain 55 gallons or more of oil. This SPCC Plan complies with the Oil Pollution Prevention regulation in Title 40 of the Code of Federal Regulations, Part 112 (40 CFR 112) and with 40 CFR 761.65(b) and (c), which regulates the temporary storage of polychlorinated biphenyls (PCBs). This Plan has also been prepared in accordance with Division 20, Chapter 6.67more » of the California Health and Safety Code (HSC 6.67) requirements for oil pollution prevention (referred to as the Aboveground Petroleum Storage Act [APSA]), and the United States Department of Energy (DOE) Order No. 436.1. This SPCC Plan establishes procedures, methods, equipment, and other requirements to prevent the discharge of oil into or upon the navigable waters of the United States or adjoining shorelines for aboveground oil storage and use at Site 300. This SPCC Plan has been prepared for the entire Site 300 facility and replaces the three previous plans prepared for Site 300: LLNL SPCC for Electrical Substations Near Buildings 846 and 865 (LLNL 2015), LLNL SPCC for Building 883 (LLNL 2015), and LLNL SPCC for Building 801 (LLNL 2014).« less

Numerical Modeling of Buried Mine Explosions

DTIC Science & Technology

2001-03-01

Lawrence Livermore Laboratory Report, UCRL -50108, Rev. 1, June 1977. 12. Dobratz, B. M., and P. C. Crawford. “LLNL Explosives Handbook.” Lawrence...Livermore National Laboratory Report, UCRL -52997, January 1985. 13. Kerley, G. I. “Multiphase Equation of State for Iron.” Sandia National Laboratories...BOX 202797 AUSTIN TX 78720-2797 1 DARPA B KASPAR 3701 N FAIRFAX DR ARLINGTON VA 22203-1714 1 US MILITARY ACADEMY MATH SCI

Laboratory Plasma Studies

DTIC Science & Technology

1989-05-23

Intense Rela- tivistic Electron Beams S . A Compact Accelerator Powercd by the Relativistic Klystron Amplifier T. Numerical and Experimental Studies of...Research Laboratory Washingto, IX 2075.6000 NRL Memorandum Report 6419 Megavolt, Multi-Kiloamp K - Band Gyrotron Oscillator Experiment W. M. BLACK,* S . H...Ka- Band Gyrotron Oscillator Experiments with Slotted and Unslotted Cavities S . H. GOLD, MEMBER, IEEE. A. W. FLIFLET, MEMBER, IEEE, W. M. MANHEIMER

Laboratory Directed Research and Development FY2008 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kammeraad, J E; Jackson, K J; Sketchley, J A

, industry, and other scientific and research institutions. By keeping the Laboratory at the forefront of science and technology, the LDRD Program enables us to meet our mission challenges, especially those of our ever-evolving national security mission. The Laboratory Directed Research and Development (LDRD) annual report for fiscal year 2008 (FY08) provides a summary of LDRD-funded projects for the fiscal year and consists of two parts: A broad description of the LDRD Program, the LDRD portfolio-management process, program statistics for the year, and highlights of accomplishments for the year. A summary of each project, submitted by the principal investigator. Project summaries include the scope, motivation, goals, relevance to Department of Energy (DOE)/National Nuclear Security Administration (NNSA) and Lawrence Livermore National Laboratory (LLNL) mission areas, the technical progress achieved in FY08, and a list of publications that resulted from the research in FY08. Summaries are organized in sections by research category (in alphabetical order). Within each research category, the projects are listed in order of their LDRD project category: Strategic Initiative (SI), Exploratory Research (ER), Laboratory-Wide Competition (LW), and Feasibility Study (FS). Within each project category, the individual project summaries appear in order of their project tracking code, a unique identifier that consists of three elements. The first is the fiscal year the project began, the second represents the project category, and the third identifies the serial number of the proposal for that fiscal year.« less

Inquiry-Based Laboratory Activities in Electrochemistry: High School Students' Achievements and Attitudes

NASA Astrophysics Data System (ADS)

Acar Sesen, Burcin; Tarhan, Leman

2013-02-01

This study aimed to investigate the effects of inquiry-based laboratory activities on high school students' understanding of electrochemistry and attitudes towards chemistry and laboratory work. The participants were 62 high school students (average age 17 years) in an urban public high school in Turkey. Students were assigned to experimental ( N = 30) and control groups ( N = 32). The experimental group was taught using inquiry-based laboratory activities developed by the researchers and the control group was instructed using traditional laboratory activities. The results of the study indicated that instruction based on inquiry-based laboratory activities caused a significantly better acquisition of scientific concepts related to electrochemistry, and produced significantly higher positive attitudes towards chemistry and laboratory. In the light of the findings, it is suggested that inquiry-based laboratory activities should be developed and applied to promote students' understanding in chemistry subjects and to improve their positive attitudes.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glascoe, Lee; Gowardhan, Akshay; Lennox, Kristin

In the interest of promoting the international exchange of technical expertise, the US Department of Energy’s Office of Emergency Operations (NA-40) and the French Commissariat à l'Energie Atomique et aux énergies alternatives (CEA) requested that the National Atmospheric Release Advisory Center (NARAC) of Lawrence Livermore National Laboratory (LLNL) in Livermore, California host a joint table top exercise with experts in emergency management and atmospheric transport modeling. In this table top exercise, LLNL and CEA compared each other’s flow and dispersion models. The goal of the comparison is to facilitate the exchange of knowledge, capabilities, and practices, and to demonstrate themore » utility of modeling dispersal at different levels of computational fidelity. Two modeling approaches were examined, a regional scale modeling approach, appropriate for simple terrain and/or very large releases, and an urban scale modeling approach, appropriate for small releases in a city environment. This report is a summary of LLNL and CEA modeling efforts from this exercise. Two different types of LLNL and CEA models were employed in the analysis: urban-scale models (Aeolus CFD at LLNL/NARAC and Parallel- Micro-SWIFT-SPRAY, PMSS, at CEA) for analysis of a 5,000 Ci radiological release and Lagrangian Particle Dispersion Models (LODI at LLNL/NARAC and PSPRAY at CEA) for analysis of a much larger (500,000 Ci) regional radiological release. Two densely-populated urban locations were chosen: Chicago with its high-rise skyline and gridded street network and Paris with its more consistent, lower building height and complex unaligned street network. Each location was considered under early summer daytime and nighttime conditions. Different levels of fidelity were chosen for each scale: (1) lower fidelity mass-consistent diagnostic, intermediate fidelity Navier-Stokes RANS models, and higher fidelity Navier-Stokes LES for urban-scale analysis, and (2) lower-fidelity single

Experimental and Modeling Characterization of PETN Mobilization Mechanisms During Recrystallization at Ambient Conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burnham, A K; Gee, R; Maiti, A

2005-11-03

Experimental measurements suggest that pentaerythritoltetranitrate (PETN) undergoes changes at the molecular level that cause macroscopic changes in the overall PETN powder characteristics over time. These changes have been attributed to the high molecular mobility of PETN, but the underlying mechanism(s) responsible for this redistribution are still uncertain. Two basic approaches have been implemented in the past year to provide insight into the nature of these underlying mechanisms. The first approach is of an experimental nature, utilizing both AFM and evaporation measurements, which address both surface mobility and evaporation. These data include AFM measurements performed at LLNL and evaporation rate measurementsmore » performed at Texas Tech. These results are compared to earlier vapor pressure measurements performed at SNL, and estimates of recrystallization time frames are given. The second approach utilizes first-principle calculations and simulations that will be used to compare directly to those experimental quantities measured. We are developing an accurate intermolecular potential for PETN, which via kinetic Monte Carlo (KMC) simulations would mimic real crystallite shapes. Once the basic theory is in place for the growth of single crystallites, we will be in a position to investigate realistic grain coarsening phenomena in multi-crystallite simulations. This will also enable us to study how to control the morphological evolution, e.g., through thermal cycling, or through the action of custom additives and impurities.« less

Laboratory Study of the Shaping and Evolution of Magnetized Episodic Plasma Jets

NASA Astrophysics Data System (ADS)

Higginson, Drew

2015-11-01

The expansion of hot, dense plasma (100 eV, 1018 cm-3) into vacuum occupied by a strong magnetic field (β =Pkinetic /Pmag ~ 1) along the expansion axis is a seemingly elementary physics problem, yet it is one that has scarcely been investigated. As well as being a fundamental problem in plasma physics, understanding such a situation is important to provide an explanation of large-scale jets observed in the formation of young stellar objects (YSO). Additionally, the ability to manipulate such a situation (e.g. to optimize x-ray emission) may be essential to the feasibility of recently proposed inertial confinement fusion (ICF) schemes with an imposed magnetic field. To investigate these situations, a CF2 foil is irradiated with the ELFIE laser (1013 W/cm2, 0.6 ns) in an external axial magnetic field of 20 T. As the plasma expands radially it is restricted by magnetic pressure that creates a cavity with a shock at the expansion edge. This shock redirects flow back on axis and creates a strong, stationary, conical shock that collimates the flow into a jet traveling over 1000 km/s and extending many centimeters. The effect of episodic heating (e.g. from variable mass ejection in a YSO, or pulse shaping in ICF) was investigated by irradiating the target with a precursor laser (1012 W/cm2, 0.6 ns) at 9 to 19 ns prior to the main pulse. The addition of this relatively small addition of energy (<20% of the main pulse energy) changed the dynamics of the expansion dramatically by increasing the strength of the conical shock, reducing the forward expansion of the cavity and dramatically increasing emission. We also present MHD simulations that reproduce the experimental observables and help to understand dynamics of jet and cavity formation. Prepared by LLNL under Contract DE-AC52-07NA27344. Presently at Lawrence Livermore National Laboratory.

Effect of Palygorskite Clay, Fertilizers, and Lime on the Degradation of Oil Products in Oligotrophic Peat Soil under Laboratory Experimental Conditions

NASA Astrophysics Data System (ADS)

Tolpeshta, I. I.; Erkenova, M. I.

2018-02-01

The effect of native palygorskite clay and that modified with dodecyltrimethylammonium chloride on the degradation of oil products in an oligotrophic peat soil under complete flooding at the application of lime and mineral fertilizers has been studied under laboratory conditions. It has been shown that the incubation of oil-contaminated soil with unmodified clay and fertilizers at the application of lime under complete flooding with water affects the dynamics of pH and Eh and slows the development of reducing conditions compared to the use of clay without fertilizers. The addition of organoclay under similar conditions favors the formation of potential-determining system with a high redox capacity, which is capable of retaining the potential on a level of 100-200 mV at pH ˜ 7 for two months. It has been found that, under the experimental conditions, unmodified and modified clay, which has no toxic effect on the bacterial complex, does not increase the biodegradation efficiency of oil products in the oligotrophic peat soil compared to the experimental treatments without clay addition. Possible reasons for no positive effect of palygorskite clay on the biodegradation rate of oil products under experimental conditions have been analyzed.

High Throughput Experimental Materials Database

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zakutayev, Andriy; Perkins, John; Schwarting, Marcus

The mission of the High Throughput Experimental Materials Database (HTEM DB) is to enable discovery of new materials with useful properties by releasing large amounts of high-quality experimental data to public. The HTEM DB contains information about materials obtained from high-throughput experiments at the National Renewable Energy Laboratory (NREL).

Study of thermal sensitivity and thermal explosion violence of energetic materials in the LLNL ODTX system

NASA Astrophysics Data System (ADS)

Hsu, P. C.; Hust, G.; Zhang, M. X.; Lorenz, T. K.; Reynolds, J. G.; Fried, L.; Springer, H. K.; Maienschein, J. L.

2014-05-01

Incidents caused by fire and combat operations can heat energetic materials that may lead to thermal explosion and result in structural damage and casualty. Some explosives may thermally explode at fairly low temperatures (< 100 °C) and the violence from thermal explosion may cause significant damage. Thus it is important to understand the response of energetic materials to thermal insults. The One Dimensional Time to Explosion (ODTX) system at the Lawrence Livermore National Laboratory has been used for decades to measure times to explosion, threshold thermal explosion temperature, and determine kinetic parameters of energetic materials. Samples of different configurations (pressed part, powder, paste, and liquid) can be tested in the system. The ODTX testing can also provide useful data for assessing the thermal explosion violence of energetic materials. Recent ODTX experimental data are reported in the paper.

The laboratory domestication of Caenorhabditis elegans.

PubMed

Sterken, Mark G; Snoek, L Basten; Kammenga, Jan E; Andersen, Erik C

2015-05-01

Model organisms are of great importance to our understanding of basic biology and to making advances in biomedical research. However, the influence of laboratory cultivation on these organisms is underappreciated, and especially how that environment can affect research outcomes. Recent experiments led to insights into how the widely used laboratory reference strain of the nematode Caenorhabditis elegans compares with natural strains. Here we describe potential selective pressures that led to the fixation of laboratory-derived alleles for the genes npr-1, glb-5, and nath-10. These alleles influence a large number of traits, resulting in behaviors that affect experimental interpretations. Furthermore, strong phenotypic effects caused by these laboratory-derived alleles hinder the discovery of natural alleles. We highlight strategies to reduce the influence of laboratory-derived alleles and to harness the full power of C. elegans. Copyright © 2015 Elsevier Ltd. All rights reserved.

Developing a Virtual Rock Deformation Laboratory

NASA Astrophysics Data System (ADS)

Zhu, W.; Ougier-simonin, A.; Lisabeth, H. P.; Banker, J. S.

2012-12-01

Experimental rock physics plays an important role in advancing earthquake research. Despite its importance in geophysics, reservoir engineering, waste deposits and energy resources, most geology departments in U.S. universities don't have rock deformation facilities. A virtual deformation laboratory can serve as an efficient tool to help geology students naturally and internationally learn about rock deformation. Working with computer science engineers, we built a virtual deformation laboratory that aims at fostering user interaction to facilitate classroom and outreach teaching and learning. The virtual lab is built to center around a triaxial deformation apparatus in which laboratory measurements of mechanical and transport properties such as stress, axial and radial strains, acoustic emission activities, wave velocities, and permeability are demonstrated. A student user can create her avatar to enter the virtual lab. In the virtual lab, the avatar can browse and choose among various rock samples, determine the testing conditions (pressure, temperature, strain rate, loading paths), then operate the virtual deformation machine to observe how deformation changes physical properties of rocks. Actual experimental results on the mechanical, frictional, sonic, acoustic and transport properties of different rocks at different conditions are compiled. The data acquisition system in the virtual lab is linked to the complied experimental data. Structural and microstructural images of deformed rocks are up-loaded and linked to different deformation tests. The integration of the microstructural image and the deformation data allows the student to visualize how forces reshape the structure of the rock and change the physical properties. The virtual lab is built using the Game Engine. The geological background, outstanding questions related to the geological environment, and physical and mechanical concepts associated with the problem will be illustrated on the web portal. In

Numerical Simulations of 3D Seismic Data Final Report CRADA No. TC02095.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friedmann, S. J.; Kostov, C.

This was a collaborative effort between Lawrence Livermore National Security, LLC (formerly The Regents of the University of Califomia)/Lawrence-Livermore National Laboratory (LLNL) and Schlumberger Cambridge Research (SCR), to develop synthetic seismic data sets and supporting codes.

ARC-2010-ACD10-0029-027

NASA Image and Video Library

2010-02-16

Lawrence Livermore National Laboratories media Day for their LLNL project aimed at aerodynamic truck and trailer devices. Tests are being preformed in the Ames Full-Scale Aerodynamic Complex 80x120 foot wind tunnel. Gabriel and Sharon Lozano.

Iodine Standard Materials: Preparation and Inter-Laboratory Comparisons

DOE Office of Scientific and Technical Information (OSTI.GOV)

D D Jenson; M L Adamic; J E Olson

of each other; there were no serial dilutions involved. Aliquots of these four materials have been submitted to five established AMS laboratories where iodine analyses are routinely performed: ETH (Zurich), CNA (Seville), PRIME (Purdue), LLNL (California), and Isotrace (Toronto.) Results from four of these laboratories have been received; in general they indicate that the desired 129/127 ratios have been achieved. We will discuss the results of this informal round-robin exercise. If the installation of the instrument in Idaho goes well, we may have some very preliminary results from the new system. An integral part of data reporting is the approach to data reduction. Accordingly, there will also be some discussion of various philosophies of data handling in regard to the use of standards to adjust data, and background subtraction.« less

Virtual laboratories: new opportunities for collaborative water science

NASA Astrophysics Data System (ADS)

Ceola, Serena; Arheimer, Berit; Bloeschl, Guenter; Baratti, Emanuele; Capell, Rene; Castellarin, Attilio; Freer, Jim; Han, Dawei; Hrachowitz, Markus; Hundecha, Yeshewatesfa; Hutton, Christopher; Lindström, Goran; Montanari, Alberto; Nijzink, Remko; Parajka, Juraj; Toth, Elena; Viglione, Alberto; Wagener, Thorsten

2015-04-01

Reproducibility and repeatability of experiments are the fundamental prerequisites that allow researchers to validate results and share hydrological knowledge, experience and expertise in the light of global water management problems. Virtual laboratories offer new opportunities to enable these prerequisites since they allow experimenters to share data, tools and pre-defined experimental procedures (i.e. protocols). Here we present the outcomes of a first collaborative numerical experiment undertaken by five different international research groups in a virtual laboratory to address the key issues of reproducibility and repeatability. Moving from the definition of accurate and detailed experimental protocols, a rainfall-runoff model was independently applied to 15 European catchments by the research groups and model results were collectively examined through a web-based discussion. We found that a detailed modelling protocol was crucial to ensure the comparability and reproducibility of the proposed experiment across groups. Our results suggest that sharing comprehensive and precise protocols and running the experiments within a controlled environment (e.g. virtual laboratory) is as fundamental as sharing data and tools for ensuring experiment repeatability and reproducibility across the broad scientific community and thus advancing hydrology in a more coherent way.

Experimental Flight Characterization of a Canard-Controlled, Subsonic Missile

DTIC Science & Technology

2017-08-01

ARL-TR-8086 ● AUG 2017 US Army Research Laboratory Experimental Flight Characterization of a Canard- Controlled , Subsonic Missile...Laboratory Experimental Flight Characterization of a Canard- Controlled , Subsonic Missile by Frank Fresconi, Ilmars Celmins, James Maley, and...valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) August 2017 2. REPORT TYPE Technical

DIissolution of low enriched uranium from the experimental breeder reactor-II fuel stored at the Idaho National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daniel, G.; Rudisill, T.; Almond, P.

The Idaho National Laboratory (INL) is actively engaged in the development of electrochemical processing technology for the treatment of fast reactor fuels using irradiated fuel from the Experimental Breeder Reactor-II (EBR-II) as the primary test material. The research and development (R&D) activities generate a low enriched uranium (LEU) metal product from the electrorefining of the EBR-II fuel and the subsequent consolidation and removal of chloride salts by the cathode processor. The LEU metal ingots from past R&D activities are currently stored at INL awaiting disposition. One potential disposition pathway is the shipment of the ingots to the Savannah River Sitemore » (SRS) for dissolution in H-Canyon. Carbon steel cans containing the LEU metal would be loaded into reusable charging bundles in the H-Canyon Crane Maintenance Area and charged to the 6.4D or 6.1D dissolver. The LEU dissolution would be accomplished as the final charge in a dissolver batch (following the dissolution of multiple charges of spent nuclear fuel (SNF)). The solution would then be purified and the 235U enrichment downblended to allow use of the U in commercial reactor fuel. To support this potential disposition path, the Savannah River National Laboratory (SRNL) developed a dissolution flowsheet for the LEU using samples of the material received from INL.« less

10 CFR 850 Implementation of Requirements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, S

2012-01-05

10 CFR 850 defines a contractor as any entity, including affiliated entities, such as a parent corporation, under contract with DOE, including a subcontractor at any tier, with responsibility for performing work at a DOE site in furtherance of a DOE mission. The Chronic Beryllium Disease Prevention Program (CBDPP) applies to beryllium-related activities that are performed at the Lawrence Livermore National Laboratory (LLNL). The CBDPP or Beryllium Safety Program is integrated into the LLNL Worker Safety and Health Program and, thus, implementation documents and responsibilities are integrated in various documents and organizational structures. Program development and management of the CBDPPmore » is delegated to the Environment, Safety and Health (ES&H) Directorate, Worker Safety and Health Functional Area. As per 10 CFR 850, Lawrence Livermore National Security, LLC (LLNS) periodically submits a CBDPP to the National Nuclear Security Administration/Livermore Site Office (NNSA/LSO). The requirements of this plan are communicated to LLNS workers through ES&H Manual Document 14.4, 'Working Safely with Beryllium.' 10 CFR 850 is implemented by the LLNL CBDPP, which integrates the safety and health standards required by the regulation, components of the LLNL Integrated Safety Management System (ISMS), and incorporates other components of the LLNL ES&H Program. As described in the regulation, and to fully comply with the regulation, specific portions of existing programs and additional requirements are identified in the CBDPP. The CBDPP is implemented by documents that interface with the workers, principally through ES&H Manual Document 14.4. This document contains information on how the management practices prescribed by the LLNL ISMS are implemented, how beryllium hazards that are associated with LLNL work activities are controlled, and who is responsible for implementing the controls. Adherence to the requirements and processes described in the ES&H Manual ensures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cooper, J. F.; Berner, J. K.

This was a collaborative effort between The Regents of the University of California, Lawrence Livermore National Laboratory (LLNL) and Contained Energy, Inc. (CEI), to conduct necessary research and to develop, fabricate and test a multi-cell carbon fuel cell.

Aseptic laboratory techniques: plating methods.

PubMed

Sanders, Erin R

2012-05-11

Microorganisms are present on all inanimate surfaces creating ubiquitous sources of possible contamination in the laboratory. Experimental success relies on the ability of a scientist to sterilize work surfaces and equipment as well as prevent contact of sterile instruments and solutions with non-sterile surfaces. Here we present the steps for several plating methods routinely used in the laboratory to isolate, propagate, or enumerate microorganisms such as bacteria and phage. All five methods incorporate aseptic technique, or procedures that maintain the sterility of experimental materials. Procedures described include (1) streak-plating bacterial cultures to isolate single colonies, (2) pour-plating and (3) spread-plating to enumerate viable bacterial colonies, (4) soft agar overlays to isolate phage and enumerate plaques, and (5) replica-plating to transfer cells from one plate to another in an identical spatial pattern. These procedures can be performed at the laboratory bench, provided they involve non-pathogenic strains of microorganisms (Biosafety Level 1, BSL-1). If working with BSL-2 organisms, then these manipulations must take place in a biosafety cabinet. Consult the most current edition of the Biosafety in Microbiological and Biomedical Laboratories (BMBL) as well as Material Safety Data Sheets (MSDS) for Infectious Substances to determine the biohazard classification as well as the safety precautions and containment facilities required for the microorganism in question. Bacterial strains and phage stocks can be obtained from research investigators, companies, and collections maintained by particular organizations such as the American Type Culture Collection (ATCC). It is recommended that non-pathogenic strains be used when learning the various plating methods. By following the procedures described in this protocol, students should be able to: Perform plating procedures without contaminating media. Isolate single bacterial colonies by the streak

Aseptic Laboratory Techniques: Plating Methods

PubMed Central

Sanders, Erin R.

2012-01-01

Microorganisms are present on all inanimate surfaces creating ubiquitous sources of possible contamination in the laboratory. Experimental success relies on the ability of a scientist to sterilize work surfaces and equipment as well as prevent contact of sterile instruments and solutions with non-sterile surfaces. Here we present the steps for several plating methods routinely used in the laboratory to isolate, propagate, or enumerate microorganisms such as bacteria and phage. All five methods incorporate aseptic technique, or procedures that maintain the sterility of experimental materials. Procedures described include (1) streak-plating bacterial cultures to isolate single colonies, (2) pour-plating and (3) spread-plating to enumerate viable bacterial colonies, (4) soft agar overlays to isolate phage and enumerate plaques, and (5) replica-plating to transfer cells from one plate to another in an identical spatial pattern. These procedures can be performed at the laboratory bench, provided they involve non-pathogenic strains of microorganisms (Biosafety Level 1, BSL-1). If working with BSL-2 organisms, then these manipulations must take place in a biosafety cabinet. Consult the most current edition of the Biosafety in Microbiological and Biomedical Laboratories (BMBL) as well as Material Safety Data Sheets (MSDS) for Infectious Substances to determine the biohazard classification as well as the safety precautions and containment facilities required for the microorganism in question. Bacterial strains and phage stocks can be obtained from research investigators, companies, and collections maintained by particular organizations such as the American Type Culture Collection (ATCC). It is recommended that non-pathogenic strains be used when learning the various plating methods. By following the procedures described in this protocol, students should be able to: ● Perform plating procedures without contaminating media. ● Isolate single bacterial colonies by the

An ultra-compact processor module based on the R3000

NASA Astrophysics Data System (ADS)

Mullenhoff, D. J.; Kaschmitter, J. L.; Lyke, J. C.; Forman, G. A.

1992-08-01

Viable high density packaging is of critical importance for future military systems, particularly space borne systems which require minimum weight and size and high mechanical integrity. A leading, emerging technology for high density packaging is multi-chip modules (MCM). During the 1980's, a number of different MCM technologies have emerged. In support of Strategic Defense Initiative Organization (SDIO) programs, Lawrence Livermore National Laboratory (LLNL) has developed, utilized, and evaluated several different MCM technologies. Prior LLNL efforts include modules developed in 1986, using hybrid wafer scale packaging, which are still operational in an Air Force satellite mission. More recent efforts have included very high density cache memory modules, developed using laser pantography. As part of the demonstration effort, LLNL and Phillips Laboratory began collaborating in 1990 in the Phase 3 Multi-Chip Module (MCM) technology demonstration project. The goal of this program was to demonstrate the feasibility of General Electric's (GE) High Density Interconnect (HDI) MCM technology. The design chosen for this demonstration was the processor core for a MIPS R3000 based reduced instruction set computer (RISC), which has been described previously. It consists of the R3000 microprocessor, R3010 floating point coprocessor and 128 Kbytes of cache memory.

The Effect of Interchanging the Polarity of the Dense Plasma Focus on Neutron Yield

NASA Astrophysics Data System (ADS)

Jiang, Sheng; Higginson, Drew; Link, Anthony; Schmidt, Andrea

2017-10-01

The dense plasma focus (DPF) Z-pinch devices can serve as portable neutron sources when deuterium is used as the filling gas. DPF devices are normally operated with the inner electrode as the anode. It has been found that interchanging the polarity of the electrodes can cause orders of magnitude decrease in the neutron yield. Here we use the particle-in-cell (PIC) code LSP to model a DPF with both polarities. We have found the difference in the shape of the sheath, the voltage and current traces, and the electric and magnetic fields in the pinch region due to different polarities. A detailed comparison will be presented. Prepared by LLNL under Contract DE-AC52-07NA27344 and supported by the Laboratory Directed Research and Development Program (15-ERD-034) at LLNL. Computing support for this work came from the LLNL Institutional Computing Grand Challenge program.

Laboratory animal science: a resource to improve the quality of science.

PubMed

Forni, M

2007-08-01

The contribution of animal experimentation to biomedical research is of undoubted value, nevertheless the real usefulness of animal models is still being hotly debated. Laboratory Animal Science is a multidisciplinary approach to humane animal experimentation that allows the choice of the correct animal model and the collection of unbiased data. Refinement, Reduction and Replacement, the "3Rs rule", are now widely accepted and have a major influence on animal experimentation procedures. Refinement, namely any decrease in the incidence or severity of inhumane procedures applied to animals, has been today extended to the entire lives of the experimental animals. Reduction of the number of animals used to obtain statistically significant data may be achieved by improving experimental design and statistical analysis of data. Replacement refers to the development of validated alternative methods. A Laboratory Animal Science training program in biomedical degrees can promote the 3Rs and improve the welfare of laboratory animals as well as the quality of science with ethical, scientific and economic advantages complying with the European requirement that "persons who carry out, take part in, or supervise procedures on animals, or take care of animals used in procedures, shall have had appropriate education and training".

Using Microcomputers in the Undergraduate Laboratory.

ERIC Educational Resources Information Center

Hovancik, John R.

1986-01-01

A computer-controlled experimental psychology investigation suitable for use in an undergraduate laboratory is described. The investigation examines the relationship between aesthetic preference and speed of reaction in making choices between colors generated on a video monitor. (Author)

Laboratory preparation questionnaires as a tool for the implementation of the Just in Time Teaching in the Physics I laboratories: Research training

NASA Astrophysics Data System (ADS)

Miranda, David A.; Sanchez, Melba J.; Forero, Oscar M.

2017-06-01

The implementation of the JiTT (Just in Time Teaching) strategy is presented to increase the previous preparation of students enrolled in the subject Physics Laboratory I offered at the Industrial University of Santander (UIS), Colombia. In this study, a laboratory preparation questionnaire (CPL) was applied as a tool for the implementation of JiTT combined with elements of mediated learning. It was found that the CPL allows to improve the students’ experience regarding the preparation of the laboratory and the development of the experimental session. These questionnaires were implemented in an academic manager (Moodle) and a web application (lab.ciencias.uis.edu.co) was used to publish the contents essential for the preparation of the student before each practical session. The most significant result was that the students performed the experimental session with the basic knowledge to improve their learning experience.

Chromosomal changes during experimental evolution in laboratory populations of Escherichia coli.

PubMed

Bergthorsson, U; Ochman, H

1999-02-01

Short-term rates of chromosome evolution were analyzed in experimental populations of Escherichia coli B that had been propagated for 2,000 generations under four thermal regimens. Chromosome alterations were monitored in 24 independent populations by pulsed-field gel electrophoresis of DNA treated with five rare-cutting restriction enzymes. A total of 11 changes, 8 affecting chromosome size and 3 altering restriction sites, were observed in these populations, with none occurring in strains cultured at 37 degreesC. Considering the changes detected in these experimental populations, the rate of chromosome alteration of E. coli is estimated to be half of that observed in experimental populations of yeast.

A Case-Based Approach Improves Science Students' Experimental Variable Identification Skills

ERIC Educational Resources Information Center

Grunwald, Sandra; Hartman, Andrew

2010-01-01

Incorporation of experimental case studies into the laboratory curriculum increases students' abilities to identify experimental variables that affect the outcome of an experiment. Here the authors describe how such case studies were incorporated using an online course management system into a biochemistry laboratory curriculum and the assessment…

Evaluation of the Use of Remote Laboratories for Secondary School Science Education

NASA Astrophysics Data System (ADS)

Lowe, David; Newcombe, Peter; Stumpers, Ben

2013-06-01

Laboratory experimentation is generally considered central to science-based education. Allowing students to "experience" science through various forms of carefully designed practical work, including experimentation, is often claimed to support their learning and motivate their engagement while fulfilling specific curriculum requirements. However, logistical constraints (most especially related to funding) place significant limitations on the ability of schools to provide and maintain high-quality science laboratory experiences and equipment. One potential solution that has recently been the subject of growing interest is the use of remotely accessible laboratories to either supplant, or more commonly to supplement, conventional hands-on laboratories. Remote laboratories allow students and teachers to use high-speed networks, coupled with cameras, sensors, and controllers, to carry out experiments on real physical laboratory apparatus that is located remotely from the student. Research has shown that when used appropriately this can bring a range of potential benefits, including the ability to share resources across multiple institutions, support access to facilities that would otherwise be inaccessible for cost or technical reasons, and provide augmentation of the experimental experience. Whilst there has been considerable work on evaluating the use of remote laboratories within tertiary education, consideration of their role within secondary school science education is much more limited. This paper describes trials of the use of remote laboratories within secondary schools, reporting on the student and teacher reactions to their interactions with the laboratories. The paper concludes that remote laboratories can be highly beneficial, but considerable care must be taken to ensure that their design and delivery address a number of critical issues identified in this paper.

Exotic quantum effects in the laboratory?

PubMed

Schützhold, Ralf

2008-08-28

This article provides a brief (non-exhaustive) review of some recent developments regarding the theoretical and possibly experimental study of 'exotic' quantum effects in the laboratory with special emphasis on cosmological particle creation, Hawking radiation and the Unruh effect.

Development of DNA Pillar Chip Final Report CRADA No. TSB-2035-01

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ness, K. D.; Long, G. W.

This was a collaborative effort between The Regents of the University of California, Lawrence Livermore National Laboratory (LLNL) and Tetracore, to demonstrate a proof of principal device for the capture and controlled release of DNA moving within a flow stream.

Counter Trafficking System Development "Analysis Training Program"

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peterson, Dennis C.

This document will detail the training curriculum for the Counter-Trafficking System Development (CTSD) Analysis Modules and Lesson Plans are derived from the United States Military, Department of Energy doctrine and Lawrence Livermore National Laboratory (LLNL), Global Security (GS) S Program.

eComLab: remote laboratory platform

NASA Astrophysics Data System (ADS)

Pontual, Murillo; Melkonyan, Arsen; Gampe, Andreas; Huang, Grant; Akopian, David

2011-06-01

Hands-on experiments with electronic devices have been recognized as an important element in the field of engineering to help students get familiar with theoretical concepts and practical tasks. The continuing increase the student number, costly laboratory equipment, and laboratory maintenance slow down the physical lab efficiency. As information technology continues to evolve, the Internet has become a common media in modern education. Internetbased remote laboratory can solve a lot of restrictions, providing hands-on training as they can be flexible in time and the same equipment can be shared between different students. This article describes an on-going remote hands-on experimental radio modulation, network and mobile applications lab project "eComLab". Its main component is a remote laboratory infrastructure and server management system featuring various online media familiar with modern students, such as chat rooms and video streaming.

Effect of experimental technique on the determination of strontium distribution coefficients of a surficial sediment from the Idaho National Engineering Laboratory, Idaho

USGS Publications Warehouse

Hemming, C.H.; Bunde, R.L.; Liszewski, M.J.; Rosentreter, J.J.; Welhan, J.

1997-01-01

The effect of experimental technique on strontium distribution coefficients (K(d)'s) was determined as part of an investigation of strontium geochemical transport properties of surficial sediment from the Idaho National Engineering Laboratory, Idaho. The investigation was conducted by the U.S. Geological Survey and Idaho State University, in cooperation with the U.S. Department of Energy. Batch experiments were conducted to quantify the effect of different experimental techniques on experimentally derived strontium K(d)'s at a fixed pH of 8.0. Combinations of three variables were investigated: method of sample agitation (rotating-mixer and shaker table), ratio of the mass-of-sediment to the volume-of-reaction-solution (1:2 and 1:20), and method of sediment preparation (crushed and non-crushed). Strontium K(d)'s ranged from 11 to 23 mlg-1 among all three experimental variables examined. Strontium K(d)'s were bimodally grouped around 12 and 21 mlg-1. Among the three experimental variables examined, the mass-to-volume ratio appeared to be the only one that could account for this bimodal distribution. The bimodal distribution of the derived strontium K(d)'s may occur because the two different mass-to-volume ratios represent different natural systems. The high mass-to-volume ratio of 1:2 models a natural system, such as an aquifer, in which there is an abundance of favorable sorption sites relative to the amount of strontium in solution. The low mass-to-volume ratio of 1:20 models a natural system, such as a stream, in which the relative amount of strontium in solution exceeds the favorable surface sorption site concentration. Except for low mass-to-volume ratios of non-crushed sediment using a rotating mixer, the method of agitation and sediment preparation appears to have little influence on derived strontium K(d)'s.The effect of experimental technique on strontium distribution coefficients (Kd's) was determined as part of an investigation of strontium geochemical

Department of Homeland Security (DHS) Proficiency Testing on Small-Scale Safety and Thermal Testing of Improvised Explosives

NASA Astrophysics Data System (ADS)

Reynolds, John; Sandstrom, Mary; Brown, Geoffrey; Warner, Kirstin; Phillips, Jason; Shelley, Timothy; Reyes, Jose; Hsu, Peter

2013-06-01

One of the first steps in establishing safe handling procedures for explosives is small-scale safety and thermal (SSST) testing. To better understand the response of improvised materials or HMEs to SSST testing, 18 HME materials were compared to 3 standard military explosives in a proficiency-type round robin study among five laboratories--2 DoD and 3 DOE--sponsored by DHS. The testing matrix has been designed to address problems encountered with improvised materials--powder mixtures, liquid suspensions, partially wetted solids, immiscible liquids, and reactive materials. Over 30 issues have been identified that indicate standard test methods may require modification when applied to HMEs to derive accurate sensitivity assessments needed for development safe handling and storage practices. This presentation will discuss experimental difficulties encountered when testing these problematic samples, show inter-laboratory testing results, show some statistical interpretation of the results, and highlight some of the testing issues. Some of the work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. LLNL-ABS-617519 (721812).

University of Maryland MRSEC - Facilities: Keck Laboratory

Science.gov Websites

MRSEC Templates Opportunities Search Home » Facilities » Keck Laboratory Shared Experimental educational institutions for non-profit administrative or educational purposes if proper credit is given to

Shallow 3-D vertical seismic profiling around a contaminant withdrawal well on the Lawrence Livermore National Laboratory Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rector, J.; Bainer, R.; Milligan, P.

1997-01-30

One of the major problems associated with ground water contaminant remediation is well placement. Optimal-placement of wells requires an accurate knowledge of geologic structure and stratigraphy in the near surface sediments and rock (0 to 100 m). Without the development of remote imaging provided by geophysical techniques, the required spacing between treatment wells may be less than 2 m in order to be confident that all contaminant reservoirs had been remediated. One method for characterizing geologic structure and stratigraphy in the near surface is vertical seismic profiling (VSP), a technique often used on deep exploration wells to calibrate surface seismicmore » reflection data. For near-surface applications, VSP data can be acquired efficiently using an array of hydrophones lowered into a fluid-filled borehole (Milligan et al, 1997). In this paper we discuss the acquisition and processing of a 3-D VSP collected at a shallow remediation site located on the grounds of the Lawrence Livermore National Laboratory (LLNL) near Livermore, California. The site was used by the United States Navy as an air training base. At this time, initial releases of hazardous materials to the environment occurred in the form of solvents [volatile organic compounds (VOCs)] that were used for the cleaning of airplanes and their parts. Gasoline, diesel and other petroleum-based compounds are also known to have leaked into the ground. California Research and Development Company, a subsidy of Standard Oil, occupied the southeastern portion of the site from 1950 to 1954. The first releases of radioactive materials to the environment occurred at this time, with the beginning of testing of radioactive materials at the site. In 1952, LLNL acquired the site. Additional releases of VOCS, polychlorinated biphenyls (PCBs), metals, radionuclides (primarily tritium), gasoline and pesticides have occurred since. These releases were due to localized spills, landfills, surface impoundments

360 Video Tour of 3D Printing Labs at LLNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Additive manufacturing is changing the way the world thinks about manufacturing and design. And here at Lawrence Livermore National Laboratory, it’s changing the way our scientists approach research and development. Today we’ll look around three of the additive manufacturing research labs on the Lawrence Livermore campus.

High-Energy Neutron Imaging Development at LLNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hall, J M; Rusnak, B; Shen, S

2005-02-16

We are proceeding with the development of a high-energy (10 MeV) neutron imaging system for use as an inspection tool in nuclear stockpile stewardship applications. Our goal is to develop and deploy an imaging system capable of detecting cubic-mm-scale voids, cracks or other significant structural defects in heavily-shielded low-Z materials within nuclear device components. The final production-line system will be relatively compact (suitable for use in existing facilities within the DOE complex) and capable of acquiring both radiographic and tomographic (CT) images. In this report, we will review our recent programmatic accomplishments, focusing primarily on progress made in FY04. Themore » design status of the high-intensity, accelerator-driven neutron source and large-format imaging detector associated with the system will be discussed and results from a recent high-energy neutron imaging experiment conducted at the Ohio University Accelerator Laboratory (OUAL) will also be presented.« less

Comparison of resistive MHD simulations and experimental CHI discharges in NSTX

NASA Astrophysics Data System (ADS)

Hooper, E. B.; Sovinec, C. R.; Raman, R.; Fatima, F.

2013-10-01

Resistive MHD simulations using NIMROD simulate CHI discharges for NSTX startup plasmas. Quantitative comparison with experiment ensures that the simulation physics includes a minimal physics set needed to extend the simulations to new experiments, e.g. NSTX-U. Important are time-varying vacuum magnetic field, ohmic heating, thermal transport, impurity radiation, and spatially-varying plasma parameters including density. Equilibria are compared with experimental injector currents, voltages and parameters including toroidal current, photographs of emitted light and measurements of midplane temperature profiles, radiation and surface heating. Initial results demonstrate that adjusting impurity radiation and cross-field transport yields temperatures and injected-current channel widths similar to experiment. These determine the plasma resistance, feeding back to the impedance on the injector power supply. Work performed under the auspices of the U.S. Department of Energy under contracts DE-AC52-07NA27344 at LLNL and DE-AC02-09CH11466 at PPPL, and grants DE-FC02-05ER54813 at PSI Center (U. Wisc.) and DOE-FG02-12ER55115 (at Princeton U.).

Analyzing "Real-World" Anomalous Data after Experimentation with a Virtual Laboratory

ERIC Educational Resources Information Center

Toth, Eva Erdosne

2016-01-01

Developing effective pedagogies to help students examine anomalous data is critical for the education of the next generation of scientists and engineers. By definition anomalous data do not concur with prior knowledge, theories and expectations. Such data are the common outcome of empirical investigation in hands-on laboratories (HOLs). These…

Artificial Neural Network Approach in Laboratory Test Reporting:  Learning Algorithms.

PubMed

Demirci, Ferhat; Akan, Pinar; Kume, Tuncay; Sisman, Ali Riza; Erbayraktar, Zubeyde; Sevinc, Suleyman

2016-08-01

In the field of laboratory medicine, minimizing errors and establishing standardization is only possible by predefined processes. The aim of this study was to build an experimental decision algorithm model open to improvement that would efficiently and rapidly evaluate the results of biochemical tests with critical values by evaluating multiple factors concurrently. The experimental model was built by Weka software (Weka, Waikato, New Zealand) based on the artificial neural network method. Data were received from Dokuz Eylül University Central Laboratory. "Training sets" were developed for our experimental model to teach the evaluation criteria. After training the system, "test sets" developed for different conditions were used to statistically assess the validity of the model. After developing the decision algorithm with three iterations of training, no result was verified that was refused by the laboratory specialist. The sensitivity of the model was 91% and specificity was 100%. The estimated κ score was 0.950. This is the first study based on an artificial neural network to build an experimental assessment and decision algorithm model. By integrating our trained algorithm model into a laboratory information system, it may be possible to reduce employees' workload without compromising patient safety. © American Society for Clinical Pathology, 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

National Ignition Facility project acquisition plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Callaghan, R.W.

The purpose of this National Ignition Facility Acquisition Plan is to describe the overall procurement strategy planned for the National Ignition Facility (NIF) Project. The scope of the plan describes the procurement activities and acquisition strategy for the following phases of the NIF Project, each of which receives either plant and capital equipment (PACE) or other project cost (OPC) funds: Title 1 and 2 design and Title 3 engineering (PACE); Optics manufacturing facilitization and pilot production (OPC); Convention facility construction (PACE); Procurement, installation, and acceptance testing of equipment (PACE); and Start-up (OPC). Activities that are part of the base Inertialmore » Confinement Fusion (ICF) Program are not included in this plan. The University of California (UC), operating Lawrence Livermore National Laboratory (LLNL) and Los Alamos National Laboratory, and Lockheed-Martin, which operates Sandia National Laboratory (SNL) and the University of Rochester Laboratory for Laser Energetics (UR-LLE), will conduct the acquisition of needed products and services in support of their assigned responsibilities within the NIF Project structure in accordance with their prime contracts with the Department of Energy (DOE). LLNL, designated as the lead Laboratory, will have responsibility for all procurements required for construction, installation, activation, and startup of the NIF.« less

Arroyo Mocho Boulder Removal Project: Lawrence Livermore National Laboratory Hetch Hetchy Pump Station

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burkholder, L; Kato, T; Van Hattem, M

2007-06-28

The purpose of this biological assessment is to review the proposed Arroyo Mocho Boulder Removal Project in sufficient detail to determine to what extent the proposed action may affect any of the threatened, endangered, proposed, or sensitive species and designated or proposed critical habitats listed below. In addition, the following information is provided to comply with statutory requirements to use the best scientific and commercial information available when assessing the risks posed to listed and/or proposed species and designated and/or proposed critical habitat by proposed federal actions. This biological assessment is prepared in accordance with legal requirements set forth undermore » regulations implementing Section 7 of the Endangered Species Act (50 CFR 402; 16 U.S.C 1536 (c)). It is our desire for the Arroyo Mocho Boulder Removal Project to receive incidental take coverage for listed species and critical habitat within the greater project area by means of amending the previous formal Section 7 consultation (1-1-04-F-0086) conducted a few hundred meters downstream by Lawrence Livermore National Laboratory (LLNL) in 2002. All conservation measures, terms and conditions, and reporting requirements from the previous Biological Opinion (1-1-04-F-0086) have been adopted for this Biological Assessment and/or amendment.« less

Measuring meaningful learning in the undergraduate chemistry laboratory

NASA Astrophysics Data System (ADS)

Galloway, Kelli R.

The undergraduate chemistry laboratory has been an essential component in chemistry education for over a century. The literature includes reports on investigations of singular aspects laboratory learning and attempts to measure the efficacy of reformed laboratory curriculum as well as faculty goals for laboratory learning which found common goals among instructors for students to learn laboratory skills, techniques, experimental design, and to develop critical thinking skills. These findings are important for improving teaching and learning in the undergraduate chemistry laboratory, but research is needed to connect the faculty goals to student perceptions. This study was designed to explore students' ideas about learning in the undergraduate chemistry laboratory. Novak's Theory of Meaningful Learning was used as a guide for the data collection and analysis choices for this research. Novak's theory states that in order for meaningful learning to occur the cognitive, affective, and psychomotor domains must be integrated. The psychomotor domain is inherent in the chemistry laboratory, but the extent to which the cognitive and affective domains are integrated is unknown. For meaningful learning to occur in the laboratory, students must actively integrate both the cognitive domain and the affective domains into the "doing" of their laboratory work. The Meaningful Learning in the Laboratory Instrument (MLLI) was designed to measure students' cognitive and affective expectations and experiences within the context of conducting experiments in the undergraduate chemistry laboratory. Evidence for the validity and reliability of the data generated by the MLLI were collected from multiple quantitative studies: a one semester study at one university, a one semester study at 15 colleges and universities across the United States, and a longitudinal study where the MLLI was administered 6 times during two years of general and organic chemistry laboratory courses. Results from

Not ''just'' pump and treat

DOE Office of Scientific and Technical Information (OSTI.GOV)

Angleberger, K; Bainer, R W

2000-12-12

The Lawrence Livermore National Laboratory (LLNL) has been consistently improving the site cleanup methods by adopting new philosophies, strategies and technologies to address constrained or declining budgets, lack of useable space due to a highly industrialized site, and significant technical challenges. As identified in the ROD, the preferred remedy at the LLNL Livermore Site is pump and treat, although LLNL has improved this strategy to bring the remediation of the ground water to closure as soon as possible. LLNL took the logical progression from a pump and treat system to the philosophy of ''Smart Pump and Treat'' coupled with themore » concepts of ''Hydrostratigraphic Unit Analysis,'' ''Engineered Plume Collapse,'' and ''Phased Source Remediation,'' which led to the development of new, more cost-effective technologies which have accelerated the attainment of cleanup goals significantly. Modeling is also incorporated to constantly develop new, cost-effective methodologies to accelerate cleanup and communicate the progress of cleanup to stakeholders. In addition, LLNL improved on the efficiency and flexibility of ground water treatment facilities. Ground water cleanup has traditionally relied on costly and obtrusive fixed treatment facilities. LLNL has designed and implemented various portable ground water treatment units to replace the fixed facilities; the application of each type of facility is determined by the amount of ground water flow and contaminant concentrations. These treatment units have allowed for aggressive ground water cleanup, increased cleanup flexibility, and reduced capital and electrical costs. After a treatment unit has completed ground water cleanup at one location, it can easily be moved to another location for additional ground water cleanup.« less

HalX: an open-source LIMS (Laboratory Information Management System) for small- to large-scale laboratories.

PubMed

Prilusky, Jaime; Oueillet, Eric; Ulryck, Nathalie; Pajon, Anne; Bernauer, Julie; Krimm, Isabelle; Quevillon-Cheruel, Sophie; Leulliot, Nicolas; Graille, Marc; Liger, Dominique; Trésaugues, Lionel; Sussman, Joel L; Janin, Joël; van Tilbeurgh, Herman; Poupon, Anne

2005-06-01

Structural genomics aims at the establishment of a universal protein-fold dictionary through systematic structure determination either by NMR or X-ray crystallography. In order to catch up with the explosive amount of protein sequence data, the structural biology laboratories are spurred to increase the speed of the structure-determination process. To achieve this goal, high-throughput robotic approaches are increasingly used in all the steps leading from cloning to data collection and even structure interpretation is becoming more and more automatic. The progress made in these areas has begun to have a significant impact on the more 'classical' structural biology laboratories, dramatically increasing the number of individual experiments. This automation creates the need for efficient data management. Here, a new piece of software, HalX, designed as an 'electronic lab book' that aims at (i) storage and (ii) easy access and use of all experimental data is presented. This should lead to much improved management and tracking of structural genomics experimental data.

Suggestions for Teaching Mathematics Using Laboratory Approaches. 6. Probability. Experimental Edition.

ERIC Educational Resources Information Center

New York State Education Dept., Albany. Bureau of Elementary Curriculum Development.

This guide is the sixth in a series of publications to assist teachers in using a laboratory approach to mathematics. Twenty activities on probability and statistics for the elementary grades are described in terms of purpose, materials needed, and procedures to be used. Objectives of these activities include basic probability concepts; gathering,…

Characterization of Jets From Exploding Bridge Wire Detonators

DTIC Science & Technology

2005-05-01

Laboratories: Albuquerque, NM, 1992. 8. Lee, E. L; Hornig, H. C.; Kury, J. W. Adiabatic Expansion of High Explosive Detonation Products; UCRL ...Dobratz, B. M. LLNL Explosives Handbook; UCRL -5299; Lawrence Livermore Laboratory, University of California: Livermore, CA 1981. 22...ATTN AFATL DLJR D LAMBERT EGLIN AFB FL 32542-6810 2 DARPA ATTN W SNOWDEN S WAX 3701 N FAIRFAX DR ARLINGTON VA 22203-1714 2 LOS

The Pyramid Liner Concept

DTIC Science & Technology

2003-06-01

Albuquerque, NM, 1992. Dobratz, B. M. LLNL Explosives Handbook; UCRL -5299; Lawrence Livermore Laboratory: Livermore, CA, 1981 Geiger, W.; Honcia, G...L.; Hornig, H. C.; Kury, J. W. Adiabatic Expansion of High Explosive Detonation Products; UCRL -50422; Lawrence Livermore National Laboratory...ARMAMENT LAB AFATL DLJR J FOSTER D LAMBERT EGLIN AFB FL 32542-6810 2 DARPA W SNOWDEN S WAX 3701 N FAIRFAX DR ARLINGTON VA

Uneasiness among laboratory technicians.

PubMed

Arluke, A

1999-01-01

Four aspects of animal experimentation cause uneasiness among many animal laboratory technicians. First, if technicians form strong attachments to lab animals, they feel conflict between their nurturing and the experimental manipulations they perform. Most technicians learn to curtail these attachments. Second, the "sacrifice" of lab animals becomes routinized and stripped of special meaning for many technicians, making killing uncomfortably rote. Third, technicians sometimes encounter outsiders who are critical of animal experimentation and ridicule the technicians for doing this work. Most technicians avoid telling outsiders about their work or take an educational approach to deal with these awkward encounters. Finally, most technicians report some ethical uneasiness about certain types of experiments and their clinical value, as well as about the use of certain animals, and they feel they cannot turn to investigators or fellow technicians to pursue such issues.

How to Read an LLNL Energy Flow Chart (Sankey Diagram)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simon, A. J.

Each year, the Lawrence Livermore National Laboratory releases energy flow charts that illustrate the nation's consumption and use of energy. A.J. Simon, group leader for LLNL’s energy program, breaks the 2015 chart down in this video, describing how to read the chart and what year-to-year trends he sees.

Requirements for Real-Time Laboratory Experimentation over the Internet.

ERIC Educational Resources Information Center

Salzmann, C.; Latchman, H. A.; Gillet, D.; Crisalle, O. D.

A prototype system based on an inverted pendulum is used to study the Quality of Service and discuss requirements of remote-experimentation systems utilized for carrying out control engineering experiments over the Internet. This class of applications involves the transmission over the network of a variety of data types with their own peculiar…

Multi-platform experiment to cross a boundary between laboratory and real situational studies: experimental discussion of cross-situational consistency of driving behaviors.

PubMed

Terai, H; Miwa, K; Okuda, H; Tazaki, Y; Suzuki, T; Kojima, K; Morita, J; Maehigashi, A; Takeda, K

2012-01-01

We constructed an innovative experimental platform to study cross-situational consistency in driving behavior, conducted behavioral experiments, and reported the data obtained in the experiment. To discuss cross-situational consistency, we separated situations in which people use some systems to conduct tasks into three independent conceptual factors: environment, context, and system. We report the experimental results with the following systems: a laboratory system with a gaming controller and steering/pedal controllers and a real system, COMS an instrumented vehicle. The results are summarized as follows. 1) The individual behaviors in each system were stable, and consistency was retained. 2) The consistency of the behaviors was also confirmed when the participants drove using different interfaces in identical systems. 3) However, only slight correlation was observed across different systems in a specific situation where a strong high-order cognitive constraint (i.e., rapid driving) and a weak low-order cognitive constraint (driving with easy handling toward a straight-line course) were given.

HILL: The High-Intensity Laser Laboratory Core Team's Reply to Questions from the NNSA Experimental Facilities Panel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Albright, B J

2012-08-02

Question 1 - The type of physics regimes that HILL can access for weapons studies is quite interesting. The question that arises for the proposal team is what priority does this type of experimental data have versus data that can be obtained with NIF, and Z. How does HILL rank in priority compared to MARIE 1.0 in terms of the experimental data it will provide? We reiterate that isochoric heating experiments to be conducted with HILL are complementary to the high energy density physics experiments at NIF and Z and uniquely access states of matter that neither other facility canmore » access. It is our belief that HILL will enable several important questions, e.g., as related to mix morphology, radiation transfer from corrugated surfaces, and equations of state, to be run to ground through carefully diagnosed, 'unit-physics' experiments. Such experiments will substantially improve confidence in our computer models and provide a rigorous science basis for certification. Question 2 - A secondary question relates to the interests of LLNL and SNL in the physics that HILL can address. This should be spelled out clearly. I would like to see the other labs be part of the discussion regarding how important this capability would be if built. Both sister Labs have a keen interest in the physics enabled by high-intensity, high-energy lasers, as evinced by the Z Petawatt and NIF ARC upgrades to their signature facilities. LANL scientists have teamed with scientists from both Laboratories in high-intensity laser 'first experiments' envisioned for HILL and we fully intend to continue these profitable discussions going forward. In the preparation of the HILL proposal, feedback was solicited from the broader HEDP and weapons science communities. The consensus view was that HILL filled a critical gap and that there was a need for a facility like HILL to address outstanding questions in weapons science. It was recognized that co-location of HILL with a facility such as MaRIE 1.0, Z

Shock wave facilities at Pulter Laboratory of SRI international

NASA Astrophysics Data System (ADS)

Murri, W. J.

1982-04-01

Shock wave research in the Poulter Laboratory covers two broad areas: dynamic material response and dynamic structural response. Workers in both areas use common facilities. The Laboratory has several guns and the facilities to perform various types of high explosive loading experiments. The use of these facilities and experimental techniques is illustrated with examples from research projects.

Conservation in the Teaching Laboratory--Substitution of Xenopus for Rana.

ERIC Educational Resources Information Center

Bernhart, David M; And Others

1991-01-01

Reports on experimental comparisons between the leopard frog, currently captured for laboratory use, and the African clawed frog, raised specifically for research. Except for the increased longevity of isolated nerve axons in the clawed frog, no other significant differences were established. Recommends laboratory use of clawed frogs as…

DSP-Based Hands-On Laboratory Experiments for Photovoltaic Power Systems

ERIC Educational Resources Information Center

Muoka, Polycarp I.; Haque, Md. Enamul; Gargoom, Ameen; Negnetvitsky, Michael

2015-01-01

This paper presents a new photovoltaic (PV) power systems laboratory module that was developed to experimentally reinforce students' understanding of design principles, operation, and control of photovoltaic power conversion systems. The laboratory module is project-based and is designed to support a renewable energy course. By using MATLAB…

DHS Summary Report -- Robert Weldon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weldon, Robert A.

This summer I worked on benchmarking the Lawrence Livermore National Laboratory fission multiplicity capability used in the Monte Carlo particle transport code MCNPX. This work involved running simulations and then comparing the simulation results with experimental experiments. Outlined in this paper is a brief description of the work completed this summer, skills and knowledge gained, and how the internship has impacted my planning for the future. Neutron multiplicity counting is a neutron detection technique that leverages the multiplicity emissions of neutrons from fission to identify various actinides in a lump of material. The identification of individual actinides in lumps ofmore » material crossing our boarders, especially U-235 and Pu-239, is a key component for maintaining the safety of the country from nuclear threats. Several multiplicity emission options from spontaneous and induced fission already existed in MCNPX 2.4.0. These options can be accessed through use of the 6th entry on the PHYS:N card. Lawrence Livermore National Laboratory (LLNL) developed a physics model for the simulation of neutron and gamma ray emission from fission and photofission that was included in MCNPX 2.7.B as an undocumented feature and then was documented in MCNPX 2.7.C. The LLNL multiplicity capability provided a different means for MCNPX to simulate neutron and gamma-ray distributions for neutron induced, spontaneous and photonuclear fission reactions. The original testing on the model for implementation into MCNPX was conducted by Gregg McKinney and John Hendricks. The model is an encapsulation of measured data of neutron multiplicity distributions from Gwin, Spencer, and Ingle, along with the data from Zucker and Holden. One of the founding principles of MCNPX was that it would have several redundant capabilities, providing the means of testing and including various physics packages. Though several multiplicity sampling methodologies already existed within MCNPX, the

Laser Materials Processing Final Report CRADA No. TC-1526-98

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crane, J.; Lehane, C. J.

2017-09-08

This CRADA project was a joint effort between Lawrence Livermore National Laboratory (LLNL) and United Technologies Corporation (UTC)/Pratt & Whitney (P&W) to demonstrate process capability for drilling holes in turbine airfoils using LLNL-developed femtosecond laser machining technology. The basis for this development was the ability of femtosecond lasers to drill precision holes in variety of materials with little or no collateral damage. The ultimate objective was to develop a laser machine tool consisting of an extremely advanced femtosecond laser subsystem to be developed by LLNL on a best-effort basis and a drilling station for turbine blades and vanes to bemore » developed by P&W. In addition, P&W was responsible for commercializing the system. The goal of the so called Advanced Laser Drilling (ALD) system was to drill specified complex hole-shapes in turbine blades and vanes with a high degree precision and repeatability and simultaneously capable of very high speed processing.« less

Estimated use of explosives in the mining industries of Algeria, Iran, Iraq, and Libya

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilburn, D.R.; Russell, J.A.; Bleiwas, D.I.

1995-09-01

This work was performed under Memorandum of Agreement B291534 Between the Lawrence Livermore National Laboratory (LLNL) and the United States Bureau of Mines. The Bureau of Mines authors are members of the Minerals Availability Field Office (MAFO) in Denver, CO, which uses an extensive network of information sources to develop and maintain the Minerals Availability database concerning mining and minerals properties worldwide. This study was initiated and directed by F. Heuze at LLNL. A previous study on the same subject had been commissioned by LLNL from the Mining Journal Research Services (MJRS) in London ,UK. Its results were integrated intomore » this report. MJRS is shown as one of the numerous sources which were used for this work. All sources are listed in the report. This document is arranged in four sections, one for each country, in alphabetical order. Thie outline is the same for each country.« less

How to Read an LLNL Energy Flow Chart (Sankey Diagram)

ScienceCinema

Simon, A. J.

2018-01-16

Each year, the Lawrence Livermore National Laboratory releases energy flow charts that illustrate the nation's consumption and use of energy. A.J. Simon, group leader for LLNL’s energy program, breaks the 2015 chart down in this video, describing how to read the chart and what year-to-year trends he sees.

360 Video Tour of 3D Printing Labs at LLNL

ScienceCinema

None

2018-01-16

Additive manufacturing is changing the way the world thinks about manufacturing and design. And here at Lawrence Livermore National Laboratory, it’s changing the way our scientists approach research and development. Today we’ll look around three of the additive manufacturing research labs on the Lawrence Livermore campus.

JANUS - A setup for low-energy Coulomb excitation at ReA3

NASA Astrophysics Data System (ADS)

Lunderberg, E.; Belarge, J.; Bender, P. C.; Bucher, B.; Cline, D.; Elman, B.; Gade, A.; Liddick, S. N.; Longfellow, B.; Prokop, C.; Weisshaar, D.; Wu, C. Y.

2018-03-01

A new experimental setup for low-energy Coulomb excitation experiments was constructed in a collaboration between the National Superconducting Cyclotron Laboratory (NSCL), Lawrence Livermore National Laboratory (LLNL), and the University of Rochester and was commissioned at the general purpose beam line of NSCL's ReA3 reaccelerator facility. The so-called JANUS setup combines γ-ray detection with the Segmented Ge Array (SeGA) and scattered particle detection using a pair of segmented double-sided Si detectors (Bambino 2). The low-energy Coulomb excitation program that JANUS enables will complement intermediate-energy Coulomb excitation studies that have long been performed at NSCL by providing access to observables that quantify collectivity beyond the first excited state, including the sign and magnitude of excited-state quadrupole moments. In this work, the setup and its performance will be described based on the commissioning run that used stable 78Kr impinging onto a 1.09 mg/cm2208Pb target at a beam energy of 3.9 MeV/u.

Water Treatment Using Advanced Ultraviolet Light Sources Final Report CRADA No. TC02089.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoppes, W.; Oster, S.

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Teknichal Services, LLC (TkS), to develop water treatment systems using advanced ultraviolet light sources. The Russian institutes involved with this project were The High Current Electronics Institute (HCEI) and Russian Institute of Technical Physics-Institute of Experimental Physics (VNIIEF). HCEI and VNIIEF developed and demonstrated the potential commercial viability of short-wavelength ultraviolet excimer lamps under a Thrust 1 Initiatives for Proliferation Prevention (IPP) Program. The goals of this collaboration were to demonstrate both the commercial viability of excilampbased watermore » disinfection and achieve further substantial operational improvement in the lamps themselves; particularly in the area of energy efficiency.« less

The LCLS Project

NASA Astrophysics Data System (ADS)

Paterson, James M.

2000-04-01

The Linac Coherent Light Source (LCLS) is a linac driven FEL which uses a 1km electron linac (the last third of the SLAC linac) and a 100m long undulator to produce 1.5 angstrom X-rays of extremely high peak brightness. This radiation is fully tranversely coherent and is in sub-picosecond long pulses. The LCLS Project is a four year R&D program to solidify the design, to develop required technologies, to optimize the cost and performance and to study the potential experimental programs using these unique beam characteristics. The program is conducted by a multi-institutional collaboration consisting of SLAC as the lead laboratory, along with ANL, BNL, LLNL, LANL and UCLA.The LCLS design and the R&D programs are described.

Knowledge, attitude, and practice (KAP) of 'teaching laboratory' technicians towards laboratory safety and waste management: a pilot interventional study.

PubMed

El-Gilany, A-H; El-Shaer, S; Khashaba, E; El-Dakroory, S A; Omar, N

2017-06-01

A quasi-experimental study was performed on 20 technicians working in the Faculty of Medicine, Mansoura University, Egypt. The knowledge, attitude, and practice (KAP) of laboratory technicians was measured before and two months after enrolling them in an intervention programme about laboratory best practice procedures. The programme addressed laboratory safety and medical waste management. The assessment was performed using a validated Arabic self-administered questionnaire. Pre- and post-intervention scores were compared using non-parametric tests. There are significant increases in the scores of KAP after implementation of the training programme. Copyright © 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Creating a Tiny Human Body on a Chip

ScienceCinema

Hunsberger, Maren; Soscia, Dave; Moya, Monica

2018-06-21

LLNL science communicator Maren Hunsberger takes us "Inside the Lab" to learn about the iChip (In-vitro Chip-based Human Investigational Platform) project at Lawrence Livermore National Laboratory. "One application of the iChip system would be to develop new pharmaceutical drugs," explains Dave Soscia, LLNL postdoc. "When you test in a mouse for example, it's not as close to the human system as you can get. If we can take human cells and put them on devices and actually mimic the structure and function of the organ systems in the human, we can actually replace animal testing and even make a better system for testing pharmaceutical drugs."

Challenges in Small Screening Laboratories: SaaS to the rescue

PubMed Central

Lemmon, Vance P.; Jia, Yuanyuan; Shi, Yan; Holbrook, S. Douglas; Bixby, John L; Buchser, William

2012-01-01

The Miami Project to Cure Paralysis, part of the University of Miami Miller School of Medicine, includes a laboratory devoted to High Content Analysis (HCA) of neurons. The goal of the laboratory is to uncover signalling pathways, genes, compounds, or drugs that can be used to promote nerve growth. HCA permits the quantification of neuronal morphology, including the lengths and numbers of axons. HCA screening of various libraries on primary neurons requires a team-based approach, a variety of process steps and complex manipulations of cells and libraries to obtain meaningful results. HCA itself produces vast amounts of information including images, well-based data and cell-based phenotypic measures. Managing experimental workflow and library data, along with the extensive amount of experimental results is challenging. For academic laboratories generating large data sets from experiments using thousands of perturbagens, a laboratory information management system (LIMS) is the data tracking solution of choice. With both productivity and efficiency as driving rationales, the Miami Project has equipped its HCA laboratory with a Software As A Service (SAAS) LIMS to ensure the quality of its experiments and workflows. The article discusses this application in detail, and how the system was selected and integrated into the laboratory. The advantages of SaaS are described. PMID:21631415

Target detection and localization in shallow water: an experimental demonstration of the acoustic barrier problem at the laboratory scale.

PubMed

Marandet, Christian; Roux, Philippe; Nicolas, Barbara; Mars, Jérôme

2011-01-01

This study demonstrates experimentally at the laboratory scale the detection and localization of a wavelength-sized target in a shallow ultrasonic waveguide between two source-receiver arrays at 3 MHz. In the framework of the acoustic barrier problem, at the 1/1000 scale, the waveguide represents a 1.1-km-long, 52-m-deep ocean acoustic channel in the kilohertz frequency range. The two coplanar arrays record in the time-domain the transfer matrix of the waveguide between each pair of source-receiver transducers. Invoking the reciprocity principle, a time-domain double-beamforming algorithm is simultaneously performed on the source and receiver arrays. This array processing projects the multireverberated acoustic echoes into an equivalent set of eigenrays, which are defined by their launch and arrival angles. Comparison is made between the intensity of each eigenray without and with a target for detection in the waveguide. Localization is performed through tomography inversion of the acoustic impedance of the target, using all of the eigenrays extracted from double beamforming. The use of the diffraction-based sensitivity kernel for each eigenray provides both the localization and the signature of the target. Experimental results are shown in the presence of surface waves, and methodological issues are discussed for detection and localization.

Quality knowledge of science through virtual laboratory as an element of visualization

NASA Astrophysics Data System (ADS)

Rizman Herga, Natasa

Doctoral dissertation discusses the use of virtual laboratory for learning and teaching chemical concepts at science classes in the seventh grade of primary school. The dissertation has got a two-part structure. In the first theoretical part presents a general platform of teaching science in elementary school, teaching forms and methods of teaching and among modern approaches we highlight experimental work. Particular emphasis was placed on the use of new technologies in education and virtual laboratories. Scientific findings on the importance of visualization of science concepts and their triple nature of their understanding are presented. These findings represent a fundamental foundation of empirical research presented in the second part of the doctoral dissertation, whose basic purpose was to examine the effectiveness of using virtual laboratory for teaching and learning chemical contents at science from students' point of view on knowledge and interest. We designed a didactic experiment in which 225 pupils participated. The work was conducted in the experimental and control group. Prior to its execution, the existing school practice among science and chemistry teachers was analysed in terms of: (1) inclusion of experimental work as a fundamental method of active learning chemical contents, (2) the use of visualization methods in the classroom and (3) the use of a virtual laboratory. The main findings of the empirical research, carried out in the school year 2012/2013, in which 48 science and chemistry participated, are that teachers often include experimental work when teaching chemical contents. Interviewed science teachers use a variety of visualization methods when presenting science concepts, in particular computer animation and simulation. Using virtual laboratory as a new strategy for teaching and learning chemical contents is not common because teachers lack special-didactic skills, enabling them to use virtual reality technology. Based on the didactic

Experimental setup for the laboratory investigation of micrometeoroid ablation using a dust accelerator.

PubMed

Thomas, Evan; Simolka, Jonas; DeLuca, Michael; Horányi, Mihály; Janches, Diego; Marshall, Robert A; Munsat, Tobin; Plane, John M C; Sternovsky, Zoltan

2017-03-01

A facility has been developed to simulate the ablation of micrometeoroids in laboratory conditions. An electrostatic dust accelerator is used to generate iron particles with velocities of 10-70 km/s. The particles are then introduced into a chamber pressurized with a target gas, where the pressure is adjustable between 0.01 and 0.5 Torr, and the particle partially or completely ablates over a short distance. An array of biased electrodes above and below the ablation path is used to collect the generated ions/electrons with a spatial resolution of 2.6 cm along the ablating particles' path, thus allowing the study of the spatiotemporal evolution of the process. For completely ablated particles, the total collected charge directly yields the ionization coefficient of a given dust material-target gas combination. The first results of this facility measured the ionization coefficient of iron atoms with N 2 , air, CO 2 , and He target gases for impact velocities >20 km/s, and are reported by Thomas et al. [Geophys. Res. Lett. 43, 3645 (2016)]. The ablation chamber is also equipped with four optical ports that allow for the detection of the light emitted by the ablating particle. A multichannel photomultiplier tube system is used to observe the ablation process with a spatial and temporal resolution of 0.64 cm and 90 ns. The preliminary results indicate that it is possible to calculate the velocity of the ablating particle from the optical observations, and in conjunction with the spatially resolved charge measurements allow for experimental validation of ablation models in future studies.

Experimental setup for the laboratory investigation of micrometeoroid ablation using a dust accelerator

NASA Astrophysics Data System (ADS)

Thomas, Evan; Simolka, Jonas; DeLuca, Michael; Horányi, Mihály; Janches, Diego; Marshall, Robert A.; Munsat, Tobin; Plane, John M. C.; Sternovsky, Zoltan

2017-03-01

A facility has been developed to simulate the ablation of micrometeoroids in laboratory conditions. An electrostatic dust accelerator is used to generate iron particles with velocities of 10-70 km/s. The particles are then introduced into a chamber pressurized with a target gas, where the pressure is adjustable between 0.01 and 0.5 Torr, and the particle partially or completely ablates over a short distance. An array of biased electrodes above and below the ablation path is used to collect the generated ions/electrons with a spatial resolution of 2.6 cm along the ablating particles' path, thus allowing the study of the spatiotemporal evolution of the process. For completely ablated particles, the total collected charge directly yields the ionization coefficient of a given dust material-target gas combination. The first results of this facility measured the ionization coefficient of iron atoms with N2, air, CO2, and He target gases for impact velocities >20 km/s, and are reported by Thomas et al. [Geophys. Res. Lett. 43, 3645 (2016)]. The ablation chamber is also equipped with four optical ports that allow for the detection of the light emitted by the ablating particle. A multichannel photomultiplier tube system is used to observe the ablation process with a spatial and temporal resolution of 0.64 cm and 90 ns. The preliminary results indicate that it is possible to calculate the velocity of the ablating particle from the optical observations, and in conjunction with the spatially resolved charge measurements allow for experimental validation of ablation models in future studies.

Experimental Setup for the Laboratory Investigation of Micrometeoroid Ablation Using a Dust Accelerator

NASA Technical Reports Server (NTRS)

Thomas, Evan; Simolka, Jonas; DeLuca, Michael; Horanyi, Mihaly; Janches, Diego; Marshall, Robert A.; Munsat, Tobin; Plane, John M. C.; Sternovsky, Zoltan

2017-01-01

A facility has been developed to simulate the ablation of micrometeoroids in laboratory conditions. An electrostatic dust accelerator is used to generate iron particles with velocities of 10-70 kilometers. The particles are then introduced into a chamber pressurized with a target gas, where the pressure is adjustable between 0.01 and 0.5 Torr, and the particle partially or completely ablates over a short distance. An array of biased electrodes above and below the ablation path is used to collect the generated ions/electrons with a spatial resolution of 2.6 centimeters along the ablating particles path, thus allowing the study of the spatiotemporal evolution of the process. For completely ablated particles, the total collected charge directly yields the ionization coefficient of a given dust material-target gas combination. The first results of this facility measured the ionization coefficient of iron atoms with N2, air, CO2, and He target gases for impact velocities greater than 20 kilometers per second, and are reported by Thomas et al. The ablation chamber is also equipped with four optical ports that allow for the detection of the light emitted by the ablating particle. A multichannel photomultiplier tube system is used to observe the ablation process with a spatial and temporal resolution of 0.64 centimeters and 90 nanoseconds. The preliminary results indicate that it is possible to calculate the velocity of the ablating particle from the optical observations, and in conjunction with the spatially resolved charge measurements allow for experimental validation of ablation models in future studies.

Preventing Boredom in the Language Laboratory

ERIC Educational Resources Information Center

Obanya, Pai

1978-01-01

An experimental year of oral testing using the language laboratory at Victoria University is described. A new first-year 12-credit course is primarily a language course based on audiovisual/lingual methods. The content, evaluation, and administration of oral expression tests and performance tapes are covered. (SW)

Integration of Video-Based Demonstrations to Prepare Students for the Organic Chemistry Laboratory

ERIC Educational Resources Information Center

Nadelson, Louis S.; Scaggs, Jonathan; Sheffield, Colin; McDougal, Owen M.

2015-01-01

Consistent, high-quality introductions to organic chemistry laboratory techniques effectively and efficiently support student learning in the organic chemistry laboratory. In this work, we developed and deployed a series of instructional videos to communicate core laboratory techniques and concepts. Using a quasi-experimental design, we tested the…

A Reverse Osmosis System for an Advanced Separation Process Laboratory.

ERIC Educational Resources Information Center

Slater, C. S.; Paccione, J. D.

1987-01-01

Focuses on the development of a pilot unit for use in an advanced separations process laboratory in an effort to develop experiments on such processes as reverse osmosis, ultrafiltration, adsorption, and chromatography. Discusses reverse osmosis principles, the experimental system design, and some experimental studies. (TW)

Bibliographic Post-Processing with the TIS Intelligent Gateway: Analytical and Communication Capabilities.

ERIC Educational Resources Information Center

Burton, Hilary D.

TIS (Technology Information System) is an intelligent gateway system capable of performing quantitative evaluation and analysis of bibliographic citations using a set of Process functions. Originally developed by Lawrence Livermore National Laboratory (LLNL) to analyze information retrieved from three major federal databases, DOE/RECON,…

Natural Pathogens of Laboratory Mice, Rats, and Rabbits and Their Effects on Research

PubMed Central

Baker, David G.

1998-01-01

Laboratory mice, rats, and rabbits may harbor a variety of viral, bacterial, parasitic, and fungal agents. Frequently, these organisms cause no overt signs of disease. However, many of the natural pathogens of these laboratory animals may alter host physiology, rendering the host unsuitable for many experimental uses. While the number and prevalence of these pathogens have declined considerably, many still turn up in laboratory animals and represent unwanted variables in research. Investigators using mice, rats, and rabbits in biomedical experimentation should be aware of the profound effects that many of these agents can have on research. PMID:9564563

Multiprog virtual laboratory applied to PLC programming learning

NASA Astrophysics Data System (ADS)

Shyr, Wen-Jye

2010-10-01

This study develops a Multiprog virtual laboratory for a mechatronics education designed to teach how to programme a programmable logic controller (PLC). The study was carried out with 34 students in the Department of Industry Education and Technology at National Changhua University of Education in Taiwan. In total, 17 students were assigned to each group, experimental and control. Two laboratory exercises were designed to provide students with experience in PLC programming. The results show that the experiments supported by Multiprog virtual laboratory user-friendly control interfaces generate positive meaningful results in regard to students' knowledge and understanding of the material.

Undergraduate Laboratory on a Turbulent Impinging Jet

NASA Astrophysics Data System (ADS)

Ivanosky, Arnaud; Brezzard, Etienne; van Poppel, Bret; Benson, Michael

2017-11-01

An undergraduate thermal sciences laboratory exercise that includes both experimental fluid mechanics and heat transfer measurements of an impinging jet is presented. The flow field is measured using magnetic resonance velocimetry (MRV) of a water flow, while IR thermography is used in the heat transfer testing. Flow Reynolds numbers for both the heat transfer and fluid mechanics tests range from 20,000-50,000 based on the jet diameter for a fully turbulent flow condition, with target surface temperatures in the heat transfer test reaching a maximum of approximately 50 Kelvin. The heat transfer target surface is subject to a measured uniform Joule heat flux, a well-defined boundary condition that allows comparison to existing correlations. The MRV generates a 3-component 3-dimensional data set, while the IR thermography provides a 2-dimensional heat transfer coefficient (or Nusselt number) map. These data sets can be post-processed and compared to existing correlations to verify data quality, and the sets can be juxtaposed to understand how flow features drive heat transfer. The laboratory setup, data acquisition, and analysis procedures are described for the laboratory experience, which can be incorporated as fluid mechanics, experimental methods, and heat transfer courses

Training to Use the Scientific Method in a First-Year Physics Laboratory: A Case Study

ERIC Educational Resources Information Center

Sarasola, Ane; Rojas, Jose Félix; Okariz, Ana

2015-01-01

In this work, a specific implementation of a so-called experimental or open-ended laboratory is proposed and evaluated. Keeping in mind the scheduling limitations imposed by the context, first-year engineering physics laboratory practices have been revised in order to facilitate acquisition of the skills that are required in the experimental work.…

Cysticercosis in laboratory rabbits.

PubMed

Owiny, J R

2001-03-01

There are no data on the current incidence of Taenia pisiformis in laboratory rabbits. Two cases of cysticercosis most likely due to T. pisiformis in laboratory rabbits (intermediate host) are presented. Both rabbits had no contact with dogs (final host); their caretakers did not work with dogs, and these caretakers changed into facility scrubs and wore gloves when working with the rabbits. Rabbit 1 may have been infected after being fed hay at our facility. In light of the life cycle of the parasite and the history of rabbit 2, it potentially could have been infected prior to arrival at our facility. There have been only three cases of tapeworm cysts in rabbits in our facility (average daily census, 250) during the last 10 years (incidence, < 1%). This report indicates that although cysticercosis is rare in laboratory rabbits, one should always be aware of such incidental findings. Although it may not produce overt illness in the rabbit, hepatic migration could adversely affect the outcome of some experimental procedures

[Laboratory animals and official Mexican norms (NOM-062-ZOO-1999)].

PubMed

de Aluja, Aline S

2002-01-01

This article concerns animal experimentation and official Mexican norm Nom 0062-Zoo-1999 entitled Technical specifications for the production, care and use of laboratory animals. The history of animal experimentation is briefly resumed. During the nineteenth century, doubts arose as to the right to expose animals to experimental procedures that frequently cause pain and suffering. The first law which protected animals against cruelty was passed in Great Britain in 1876; subsequently, other nations approved similar legislation. During the second part of the twentieth century, opposition to animal experimentation grew. Other groups, mainly scientists and pharmaceutical concerns, defended the right to use animals in research. New knowledge concerning the neurophysiology, cognitive capacity, and the animal faculty to experience pain is briefly mentioned. Guidelines on care and use of animals used in research published in several countries are listed. Finally, the recently published Mexican legislation (Norm) referring to production, care and use of laboratory animals is discussed and its benefits are stressed.

Life Sciences Laboratories for the Shuttle/Spacelab

NASA Technical Reports Server (NTRS)

Schulte, L. O.; Kelly, H. B.; Secord, T. C.

1976-01-01

Space Shuttle and Spacelab missions will provide scientists with their first opportunity to participate directly in research in space for all scientific disciplines, particularly the Life Sciences. Preparations are already underway to ensure the success of these missions. The paper summarizes the results of the 1975 NASA-funded Life Sciences Laboratories definition study which defined several long-range life sciences research options and the laboratory designs necessary to accomplish high-priority life sciences research. The implications and impacts of Spacelab design and development on the life sciences missions are discussed. An approach is presented based upon the development of a general-purposs laboratory capability and an inventory of common operational research equipment for conducting life sciences research. Several life sciences laboratories and their capabilities are described to demonstrate the systems potentially available to the experimenter for conducting biological and medical research.

NASA's Propulsion Research Laboratory

NASA Technical Reports Server (NTRS)

2004-01-01

The grand opening of NASA's new, world-class laboratory for research into future space transportation technologies located at the Marshall Space Flight Center (MSFC) in Huntsville, Alabama, took place in July 2004. The state-of-the-art Propulsion Research Laboratory (PRL) serves as a leading national resource for advanced space propulsion research. Its purpose is to conduct research that will lead to the creation and development of innovative propulsion technologies for space exploration. The facility is the epicenter of the effort to move the U.S. space program beyond the confines of conventional chemical propulsion into an era of greatly improved access to space and rapid transit throughout the solar system. The laboratory is designed to accommodate researchers from across the United States, including scientists and engineers from NASA, the Department of Defense, the Department of Energy, universities, and industry. The facility, with 66,000 square feet of useable laboratory space, features a high degree of experimental capability. Its flexibility allows it to address a broad range of propulsion technologies and concepts, such as plasma, electromagnetic, thermodynamic, and propellant propulsion. An important area of emphasis is the development and utilization of advanced energy sources, including highly energetic chemical reactions, solar energy, and processes based on fission, fusion, and antimatter. The Propulsion Research Laboratory is vital for developing the advanced propulsion technologies needed to open up the space frontier, and sets the stage of research that could revolutionize space transportation for a broad range of applications.

Electromagnetic (EM) earthquake precursor transmission and detection regarding experimental field and laboratory results.

NASA Astrophysics Data System (ADS)

Jones, Kenneth B., II; Saxton, Patrick

2016-04-01

Aside from understanding the animal kingdom reacting to a per-earthquake signal, a transmission source is apparent. The focus of this investigation is an electromagnetic emission approach and detection capable of becoming both practical and reliable to other plausible earthquake precursors. To better determine this method, several prototype magnetometers were devised and built with each successive version improving upon the next. Two twin (prototype #2) antennae were deployed to field settings outside the NE Texas town of Timpson, TX back in February, 2013 and very recent laboratory tests using the most refined (prototype #4) experimental antenna for detecting unconfined, granitic block fracturing. Field testing encompassed the small NE Texas town of Timpson, TX, which endured an earthquake phenomenon (May, 2012 - September, 2013). A rare sequence of events was strictly attributed to hydraulic fracturing activity in the immediate area all for hydrocarbon capture; thus, a chance to detect and record man-made earthquake activity. By swiveling two directional antennae at three locations, one mobile, the antennae could 'zero' in on a signal source until its pattern was well established and mapped, accordingly. Three signals were detected, two strong and one moderately strong, each with epicenter implications several kilometers from known seismological sites. Six months later, two M4s and a M2.4 earthquake hit over the 2013 Labor Day weekend. Hydraulic pump pressure increased deep Earth pore pressure, reduced friction, and displaced opposing tectonic stresses causing rock to fracture. This was the last earthquake sequence in the Timpson area, due to personal involvement and area citizens in contact with their state representatives. Well and drilling operations have since moved 40-50 miles SE of Timpson, TX and rare earthquake activity has now occurred there. Laboratory testing was next performed using cored granitic blocks and the latest, improved antenna with an

The Aeronautical Laboratory of the Stockholm Technical Institute

NASA Technical Reports Server (NTRS)

Malmer, Ivar

1935-01-01

This report presents a detailed analysis and history of the construction and operation of the aeronautical laboratory of the Stockholm Technical Institute. Engines and balances are discussed and experimental results are also given.

Initial experimental results from the Laboratory Biosphere closed ecological system facility

NASA Astrophysics Data System (ADS)

Alling, A.; Allen, J.; Dempster, W.; Nelson, M.; Silverstone, S.; van Thillo, M.

Results from the closure and initial closed ecological system research in the "Laboratory Biosphere" facility in Santa Fe, New Mexico (USA) will be presented. The facility was initially sealed in April 2002; and the first crop experiments with soybeans commenced in May 2002. The Laboratory Biosphere was created by the team which invented, built and operated Biosphere 2 during its years of closed ecological system functioning (1991-94) and is a testbed to build upon the lessons learned. It is an opportunity to continue experiments with a sustainable soil based agriculture system unlike most bioregenerative systems which use hydroponic systems dependent on a supply of nutrient solution. Because of the small volume of the system (34-45 m3), developing mechanisms to keep parameters like carbon dioxide within acceptable limits will be critical. Recycle of nutrients within the system to maintain soil fertility; and the ability of the inherent complex ecology of soils and a soil bed reactor to handle trace gas buildups are primary research goals. Other research goals are determination of short and long-term exchanges between soil, plants and atmosphere, especially for carbon dioxide, oxygen, nitrogen, NOX, and methane, impact of cultivation (tillage) on soil/atmospheric exchanges., investigation and development of strategies to return nutrients to the soil to maintain fertility, e.g. shredding biomass vs. composting, impact on soil chemistry of returning leachate water to the soil as irrigation water. The microbiological status of soils prior to experiments and over time will allow measurement of changes in microbial diversity and the determination of the role of soil microbes in biogeochemical cycles. Integration of automated sensor and control in the system with real-time modeling has importance for operation, research and educational outreach programs. The Laboratory Biosphere is intended to test and develop a "cybersphere" (network of shared intelligence) that may be

A Model for Designing Adaptive Laboratory Evolution Experiments.

PubMed

LaCroix, Ryan A; Palsson, Bernhard O; Feist, Adam M

2017-04-15

The occurrence of mutations is a cornerstone of the evolutionary theory of adaptation, capitalizing on the rare chance that a mutation confers a fitness benefit. Natural selection is increasingly being leveraged in laboratory settings for industrial and basic science applications. Despite increasing deployment, there are no standardized procedures available for designing and performing adaptive laboratory evolution (ALE) experiments. Thus, there is a need to optimize the experimental design, specifically for determining when to consider an experiment complete and for balancing outcomes with available resources (i.e., laboratory supplies, personnel, and time). To design and to better understand ALE experiments, a simulator, ALEsim, was developed, validated, and applied to the optimization of ALE experiments. The effects of various passage sizes were experimentally determined and subsequently evaluated with ALEsim, to explain differences in experimental outcomes. Furthermore, a beneficial mutation rate of 10 -6.9 to 10 -8.4 mutations per cell division was derived. A retrospective analysis of ALE experiments revealed that passage sizes typically employed in serial passage batch culture ALE experiments led to inefficient production and fixation of beneficial mutations. ALEsim and the results described here will aid in the design of ALE experiments to fit the exact needs of a project while taking into account the resources required and will lower the barriers to entry for this experimental technique. IMPORTANCE ALE is a widely used scientific technique to increase scientific understanding, as well as to create industrially relevant organisms. The manner in which ALE experiments are conducted is highly manual and uniform, with little optimization for efficiency. Such inefficiencies result in suboptimal experiments that can take multiple months to complete. With the availability of automation and computer simulations, we can now perform these experiments in an optimized

Laboratory analyses of micron-sized solid grains: Experimental techniques and recent results

NASA Technical Reports Server (NTRS)

Colangeli, L.; Bussoletti, E.; Blanco, A.; Borghesi, A.; Fonti, S.; Orofino, V.; Schwehm, G.

1989-01-01

Morphological and spectrophotometric investigations have been extensively applied in the past years to various kinds of micron and/or submicron-sized grains formed by materials which are candidate to be present in space. The samples are produced in the laboratory and then characterized in their physio-chemical properties. Some of the most recent results obtained on various kinds of carbonaceous materials are reported. Main attention is devoted to spectroscopic results in the VUV and IR wavelength ranges, where many of the analyzed samples show typical fingerprints which can be identified also in astrophysical and cometary materials. The laboratory methodologies used so far are also critically discussed in order to point out capabilities and present limitations, in the view of possible application to returned comet samples. Suggestions are given to develop new techniques which should overcome some of the problems faced in the manipulation and analysis of micron solid samples.

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke

PubMed Central

Maysami, Samaneh; Wong, Raymond; Pradillo, Jesus M; Denes, Adam; Dhungana, Hiramani; Malm, Tarja; Koistinaho, Jari; Orset, Cyrille; Rahman, Mahbubur; Rubio, Marina; Schwaninger, Markus; Vivien, Denis; Bath, Philip M; Rothwell, Nancy J

2015-01-01

Stroke represents a global challenge and is a leading cause of permanent disability worldwide. Despite much effort, translation of research findings to clinical benefit has not yet been successful. Failure of neuroprotection trials is considered, in part, due to the low quality of preclinical studies, low level of reproducibility across different laboratories and that stroke co-morbidities have not been fully considered in experimental models. More rigorous testing of new drug candidates in different experimental models of stroke and initiation of preclinical cross-laboratory studies have been suggested as ways to improve translation. However, to our knowledge, no drugs currently in clinical stroke trials have been investigated in preclinical cross-laboratory studies. The cytokine interleukin 1 is a key mediator of neuronal injury, and the naturally occurring interleukin 1 receptor antagonist has been reported as beneficial in experimental studies of stroke. In the present paper, we report on a preclinical cross-laboratory stroke trial designed to investigate the efficacy of interleukin 1 receptor antagonist in different research laboratories across Europe. Our results strongly support the therapeutic potential of interleukin 1 receptor antagonist in experimental stroke and provide further evidence that interleukin 1 receptor antagonist should be evaluated in more extensive clinical stroke trials. PMID:26661169

Inorganic nitrogen retention by watersheds at Fernow Experimental Forest and Coweeta Hydrologic Laboratory

Treesearch

Mary Beth Adams; Jennifer D. Knoepp; Jackson R. Webster

2014-01-01

Because elevated N loading can impair both terrestrial and aquatic ecosystems, understanding the abiotic and biotic controls over retention and export of dissolved inorganic N (DIN) is crucial. Long-term research has been conducted on experimental watersheds at two U.S. Forest Service experimental forests in the Appalachian region: Fernow Experimental Forest (FEF) in...

A Laboratory Exercise with Related Rates.

ERIC Educational Resources Information Center

Sworder, Steven C.

A laboratory experiment, based on a simple electric circuit that can be used to demonstrate the existence of real-world "related rates" problems, is outlined and an equation for voltage across the capacitor terminals during discharge is derived. The necessary materials, setup methods, and experimental problems are described. A student laboratory…

Plan of Action: JASPER Management Prestart Review (Surrogate Material Experiment)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cooper, W E

2000-12-05

The Lawrence Livermore National Laboratory (LLNL) Joint Actinide Shock Physics Experimental Research (JASPER) Facility is being developed at the Nevada Test Site (NTS) to conduct shock physics experiments on special nuclear material and other actinide materials. JASPER will use a two-stage, light-gas gun to shoot projectiles at actinide targets. Projectile velocities will range from 1 to 8 km/s, inducing pressures in the target material up to 6 Mbar. The JASPER gas gun has been designed to match the critical dimensions of the two-stage, light-gas gun in Building 341 of LLNL. The goal in copying the LLNL gun design is tomore » take advantage of the extensive ballistics database that exists and to minimize the effort spent on gun characterization in the initial facility start-up. A siting study conducted by an inter-Laboratory team identified Able Site in Area 27 of the NTS as the best location for the JASPER gas gun. Able Site consists of three major buildings that had previously been used to support the nuclear test program. In April 1999, Able Site was decommissioned as a Nuclear Explosive Assembly Facility and turned back to the DOE for other uses. Construction and facility modifications at Able Site to support the JASPER project started in April 1999 and were completed in September 1999. The gas gun and the secondary confinement chamber (SCC) were installed in early 2000. During the year, all facility and operational systems were brought on line. Initial system integration demonstrations were completed in September 2000. The facility is anticipated to be operational by August 2001, and the expected life cycle for the facility is 10 years. LLNL Nevada Experiments and Operations (N) Program has established a Management Prestart Review (MPR) team to determine the readiness of the JASPER personnel and facilities to initiate surrogate-material experiments. The review coincides with the completion of authorization-basis documents and physical subsystems, which have

Plan of Action: JASPER Management Prestart Review (Surrogate Material Experiments)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cooper, W.E.

2000-09-29

The Lawrence Livermore National Laboratory (LLNL) Joint Actinide Shock Physics Experimental Research (JASPER) Facility is being developed at the Nevada Test Site (NTS) to conduct shock physics experiments on special nuclear material and other actinide materials. JASPER will use a two-stage, light-gas gun to shoot projectiles at actinide targets. Projectile velocities will range from 1 to 8 km/s, inducing pressures in the target material up to 6 Mbar. The JASPER gas gun has been designed to match the critical dimensions of the two-stage, light-gas gun in Building 341 of LLNL. The goal in copying the LLNL gun design is tomore » take advantage of the extensive ballistics database that exists and to minimize the effort spent on gun characterization in the initial facility start-up. A siting study conducted by an inter-Laboratory team identified Able Site in Area 27 of the NTS as the best location for the JASPER gas gun. Able Site consists of three major buildings that had previously been used to support the nuclear test program. In April 1999, Able Site was decommissioned as a Nuclear Explosive Assembly Facility and turned back to the DOE for other uses. Construction and facility modifications at Able Site to support the JASPER project started in April 1999 and were completed in September 1999. The gas gun and the secondary confinement chamber (SCC) were installed in early 2000. During the year, all facility and operational systems were brought on line. Initial system integration demonstrations were completed in September 2000. The facility is anticipated to be operational by August 2001, and the expected life cycle for the facility is 10 years. LLNL Nevada Experiments and Operations (N) Program has established a Management Prestart Review (MPR) team to determine the readiness of the JASPER personnel and facilities to initiate surrogate-material experiments. The review coincides with the completion of authorization-basis documents and physical subsystems, which have

"TIS": An Intelligent Gateway Computer for Information and Modeling Networks. Overview.

ERIC Educational Resources Information Center

Hampel, Viktor E.; And Others

TIS (Technology Information System) is being used at the Lawrence Livermore National Laboratory (LLNL) to develop software for Intelligent Gateway Computers (IGC) suitable for the prototyping of advanced, integrated information networks. Dedicated to information management, TIS leads the user to available information resources, on TIS or…

Rapid Assessment of Individual Soldier Operational Readiness Final Report CRADA No. TC02104.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Turteltaub, K.; Mapes, J.

This was a collaborative effort between Lawrence Livermore National Security (LLNS) (formerly The Regents of the University of California), Lawrence Livermore National Laboratory (LLNL) and Rules Based Medicine, Inc. {RBM), to identify markers in blood that would be candidates for determining the combat readiness of troops.

Teaching experimental design.

PubMed

Fry, Derek J

2014-01-01

Awareness of poor design and published concerns over study quality stimulated the development of courses on experimental design intended to improve matters. This article describes some of the thinking behind these courses and how the topics can be presented in a variety of formats. The premises are that education in experimental design should be undertaken with an awareness of educational principles, of how adults learn, and of the particular topics in the subject that need emphasis. For those using laboratory animals, it should include ethical considerations, particularly severity issues, and accommodate learners not confident with mathematics. Basic principles, explanation of fully randomized, randomized block, and factorial designs, and discussion of how to size an experiment form the minimum set of topics. A problem-solving approach can help develop the skills of deciding what are correct experimental units and suitable controls in different experimental scenarios, identifying when an experiment has not been properly randomized or blinded, and selecting the most efficient design for particular experimental situations. Content, pace, and presentation should suit the audience and time available, and variety both within a presentation and in ways of interacting with those being taught is likely to be effective. Details are given of a three-day course based on these ideas, which has been rated informative, educational, and enjoyable, and can form a postgraduate module. It has oral presentations reinforced by group exercises and discussions based on realistic problems, and computer exercises which include some analysis. Other case studies consider a half-day format and a module for animal technicians. © The Author 2014. Published by Oxford University Press on behalf of the Institute for Laboratory Animal Research. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Bartlett Experimental Forest

Treesearch

Jane Gamal-Eldin

1998-01-01

The Bartlett Experimental Forest is a field laboratory for research on the ecology and management of northern forest ecosystems. Research on the Bartlett includes: 1) extensive investigations on structure and dynamics of forests at several levels, and developing management alternatives to reflect an array of values and benefits sought by users of forest lands, 2) a...

Review of sensors for the in situ chemical characterization of the Hanford underground storage tanks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kyle, K.R.; Mayes, E.L.

1994-07-29

Lawrence Livermore National Laboratory (LLNL), in the Technical Task Plan (TTP) SF-2112-03 subtask 2, is responsible for the conceptual design of a Raman probe for inclusion in the in-tank cone penetrometer. As part of this task, LLNL is assigned the further responsibility of generating a report describing a review of sensor technologies other than Raman that can be incorporated in the in-tank cone penetrometer for the chemical analysis of the tank environment. These sensors would complement the capabilities of the Raman probe, and would give information on gaseous, liquid, and solid state species that are insensitive to Raman interrogation. Thismore » work is part of a joint effort involving several DOE laboratories for the design and development of in-tank cone penetrometer deployable systems for direct UST waste characterization at Westinghouse Hanford Company (WHC) under the auspices of the U.S. Department of Energy (DOE) Underground Storage Tank Integrated Demonstration (UST-ID).« less

2010 Annual Health Physics Report for the HEU Transparency Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Radev, Radoslav

2011-05-16

During the 2010 calendar year, Lawrence Livermore National Laboratory (LLNL) provided health physics support for the Highly Enriched Uranium (HEU) Transparency Program for external and internal radiation protection. LLNL also provided technical expertise related to BDMS radioactive sources and Russian radiation safety regulatory compliance. For the calendar year 2010, there were 141 person-trips that required dose monitoring of the U.S. monitors. Of the 141 person-trips, 129 person-trips were Special Monitoring Visits (SMVs) and 12 person-trips were Transparency Monitoring Office (TMO) trips. In 8 of these TMO trips the TMO monitors participated also in the UEIE SMVs and in 2 TMOmore » trips the TMO monitors participated in UEIE and MPA SMVs. There were three monitoring visits (source changes) that were back-to-back SMVs with a total of 25 monitors. LLNL’s Hazard Control Department laboratories provided the dosimetry services for the HEU Transparency monitors.« less

Experimental Validation of an Integrated Controls-Structures Design Methodology

NASA Technical Reports Server (NTRS)

Maghami, Peiman G.; Gupta, Sandeep; Elliot, Kenny B.; Walz, Joseph E.

1996-01-01

The first experimental validation of an integrated controls-structures design methodology for a class of large order, flexible space structures is described. Integrated redesign of the controls-structures-interaction evolutionary model, a laboratory testbed at NASA Langley, was described earlier. The redesigned structure was fabricated, assembled in the laboratory, and experimentally tested against the original structure. Experimental results indicate that the structure redesigned using the integrated design methodology requires significantly less average control power than the nominal structure with control-optimized designs, while maintaining the required line-of-sight pointing performance. Thus, the superiority of the integrated design methodology over the conventional design approach is experimentally demonstrated. Furthermore, amenability of the integrated design structure to other control strategies is evaluated, both analytically and experimentally. Using Linear-Quadratic-Guassian optimal dissipative controllers, it is observed that the redesigned structure leads to significantly improved performance with alternate controllers as well.

[Ethical issue in animal experimentation].

PubMed

Parodi, André-Laurent

2009-11-01

In the 1970s, under pressure from certain sections of society and thanks to initiatives by several scientific research teams, committees charged with improving the conditions of laboratory animals started to be created, first in the United States and subsequently in Europe. This led to the development of an ethical approach to animal experimentation, taking into account new scientific advances. In addition to the legislation designed to provide a legal framework for animal experimentation and to avoid abuses, this ethical approach, based on the concept that animals are sentient beings, encourages greater respect of laboratory animals and the implementation of measures designed to reduce their suffering. Now, all animal experiments must first receive ethical approval--from in-house committees in the private sector and from regional committees for public institutions. Very recently, under the impetus of the French ministries of research and agriculture, the National committee for ethical animal experimentation published a national ethical charter on animal experimentation, setting the basis for responsible use of animals for scientific research and providing guidelines for the composition and functioning of ethics committees. Inspired by the scientific community itself this ethical standardization should help to assuage--but not eliminate--the reticence and hostility expressed by several sections of society.

FY06 L2C2 HE program report Zaug et al.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zaug, J M; Crowhurst, J C; Howard, W M

2008-08-01

The purpose of this project is to advance the improvement of LLNL thermochemical computational models that form the underlying basis or input for laboratory hydrodynamic simulations. Our general work approach utilizes, by design, tight experimental-theoretical research interactions that allow us to not empirically, but rather more scientifically improve LLNL computational results. The ultimate goal here is to confidently predict through computer models, the performance and safety parameters of currently maintained, modified, and newly designed stockpile systems. To attain our goal we make relevant experimental measurements on candidate detonation products constrained under static high-pressure and temperature conditions. The reduced information frommore » these measurements is then used to construct analytical forms that describe the potential surface (repulsive energy as a function of interatomic separation distance) of single and mixed fluid or detonation product species. These potential surface shapes are also constructed using input from well-trusted shock wave physics and assorted thermodynamic data available in the open literature. Our potential surfaces permit one to determine the equations of state (P,V,T), the equilibrium chemistry, phase, and chemical interactions of detonation products under a very wide range of extreme pressure temperature conditions. Using our foundation of experimentally refined potential surfaces we are in a position to calculate, with confidence, the energetic output and chemical speciation occurring from a specific combustion and/or detonation reaction. The thermochemical model we developed and use for calculating the equilibrium chemistry, kinetics, and energy from ultrafast processes is named 'Cheetah'. Computational results from our Cheetah code are coupled to laboratory ALE3D hydrodynamic simulation codes where the complete response behavior of an existing or proposed system is ultimately predicted. The Cheetah thermochemical

The Shock Compression Laboratory at Harvard: A New Facility for Planetary Impact Processes

NASA Technical Reports Server (NTRS)

Stewart, S. T.

2004-01-01

The Shock Compression Laboratory in the Department of Earth and Planetary Sciences at Harvard is a new facility for the study of impact and collisional phenomena. The following describes the experimental capabilities of the laboratory.

The Master level optics laboratory at the Institute of Optics

NASA Astrophysics Data System (ADS)

Adamson, Per

2017-08-01

The master level optics laboratory is a biannual, intensive laboratory course in the fields of geometrical, physical and modern optics. This course is intended for the master level student though Ph.D. advisors which often recommend it to their advisees. The students are required to complete five standard laboratory experiments and an independent project during a semester. The goals of the laboratory experiments are for the students to get hands-on experience setting up optical laboratory equipment, collecting and analyzing data, as well as to communicate key results. The experimental methods, analysis, and results of the standard experiments are submitted in a journal style report, while an oral presentation is given for the independent project.

Crashworthiness analysis using advanced material models in DYNA3D

DOE Office of Scientific and Technical Information (OSTI.GOV)

Logan, R.W.; Burger, M.J.; McMichael, L.D.

1993-10-22

As part of an electric vehicle consortium, LLNL and Kaiser Aluminum are conducting experimental and numerical studies on crashworthy aluminum spaceframe designs. They have jointly explored the effect of heat treat on crush behavior and duplicated the experimental behavior with finite-element simulations. The major technical contributions to the state of the art in numerical simulation arise from the development and use of advanced material model descriptions for LLNL`s DYNA3D code. Constitutive model enhancements in both flow and failure have been employed for conventional materials such as low-carbon steels, and also for lighter weight materials such as aluminum and fiber compositesmore » being considered for future vehicles. The constitutive model enhancements are developed as extensions from LLNL`s work in anisotropic flow and multiaxial failure modeling. Analysis quality as a function of level of simplification of material behavior and mesh is explored, as well as the penalty in computation cost that must be paid for using more complex models and meshes. The lightweight material modeling technology is being used at the vehicle component level to explore the safety implications of small neighborhood electric vehicles manufactured almost exclusively from these materials.« less

Project Laboratory for First-Year Students

ERIC Educational Resources Information Center

Planinsic, Gorazd

2007-01-01

This paper reports the modification of an existing experimental subject into a project laboratory for first-year physics students studying in the first cycle of university level and at a higher professional level. The subject is aimed at developing important science-related competences and skills through concrete steps under circumstances that are…

Graphing techniques for materials laboratory using Excel

NASA Technical Reports Server (NTRS)

Kundu, Nikhil K.

1994-01-01

Engineering technology curricula stress hands on training and laboratory practices in most of the technical courses. Laboratory reports should include analytical as well as graphical evaluation of experimental data. Experience shows that many students neither have the mathematical background nor the expertise for graphing. This paper briefly describes the procedure and data obtained from a number of experiments such as spring rate, stress concentration, endurance limit, and column buckling for a variety of materials. Then with a brief introduction to Microsoft Excel the author explains the techniques used for linear regression and logarithmic graphing.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leitner, M.; Bieniosek, F.; Kwan, J.

The Heavy Ion Fusion Science Virtual National Laboratory (HIFS-VNL), a collaboration between Lawrence Berkeley National Laboratory (LBNL), Lawrence Livermore National Laboratory (LLNL), and Princeton Plasma Physics Laboratory (PPPL), is currently constructing a new induction linear accelerator, called Neutralized Drift Compression eXperiment NDCX-II. The accelerator design makes effective use of existing components from LLNL's decommissioned Advanced Test Accelerator (ATA), especially induction cells and Blumlein voltage sources that have been transferred to LBNL. We have developed an aggressive acceleration 'schedule' that compresses the emitted ion pulse from 500 ns to 1 ns in just 15 meters. In the nominal design concept, 30more » nC of Li{sup +} are accelerated to 3.5 MeV and allowed to drift-compress to a peak current of about 30 A. That beam will be utilized for warm dense matter experiments investigating the interaction of ion beams with matter at high temperature and pressure. Construction of the accelerator will be complete within a period of approximately two and a half years and will provide a worldwide unique opportunity for ion-driven warm dense matter experiments as well as research related to novel beam manipulations for heavy ion fusion drivers.« less

Feasibility of processing the experimental breeder reactor-II driver fuel from the Idaho National Laboratory through Savannah River Site's H-Canyon facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Magoulas, V. E.

Savannah River National Laboratory (SRNL) was requested to evaluate the potential to receive and process the Idaho National Laboratory (INL) uranium (U) recovered from the Experimental Breeder Reactor II (EBR-II) driver fuel through the Savannah River Site’s (SRS) H-Canyon as a way to disposition the material. INL recovers the uranium from the sodium bonded metallic fuel irradiated in the EBR-II reactor using an electrorefining process. There were two compositions of EBR-II driver fuel. The early generation fuel was U-5Fs, which consisted of 95% U metal alloyed with 5% noble metal elements “fissium” (2.5% molybdenum, 2.0% ruthenium, 0.3% rhodium, 0.1% palladium,more » and 0.1% zirconium), while the later generation was U-10Zr which was 90% U metal alloyed with 10% zirconium. A potential concern during the H-Canyon nitric acid dissolution process of the U metal containing zirconium (Zr) is the explosive behavior that has been reported for alloys of these materials. For this reason, this evaluation was focused on the ability to process the lower Zr content materials, the U-5Fs material.« less

An analysis of laboratory activities found in "Applications In Biology/Chemistry: A Contextual Approach to Laboratory Science"

NASA Astrophysics Data System (ADS)

Haskins, Sandra Sue

The purpose of this study was to quantitatively determine whether the material found in ABC promotes scientific inquiry through the inclusion of science process skills, and to quantitatively determine the type (experimental, comparative, or descriptive) and character (wet-lab, paper and pencil, model, or computer) of laboratory activities. The research design allowed for an examination of the frequency and type of science process skills required of students in 79 laboratory activities sampled from all 12 units utilizing a modified 33-item laboratory analysis inventory (LAI) (Germane et al, 1996). Interrater reliability for the science process skills was completed on 19 of the laboratory activities with a mean score of 86.1%. Interrater reliability for the type and character of the laboratory, on the same 19 laboratory activities, was completed with mean scores of 79.0% and 96.5%, respectively. It was found that all laboratory activities provide a prelaboratory activity. In addition, the science process skill category of student performance is required most often of students with the skill of learning techniques or manipulating apparatus occurring 99% of the time. The science process skill category observed the least was student planning and design, occurring only 3% of the time. Students were rarely given the opportunity to practice science process skills such as developing and testing hypotheses through experiments they have designed. Chi-square tests, applied at the .05 level of significance, revealed that there was a significant difference in the type of laboratory activities; comparative laboratory activities appeared more often (59%). In addition the character of laboratory activities, "wet-lab" activities appeared more often (90%) than any of the others.

A Novel Laboratory Activity for Teaching about the Evolution of Multicellularity

ERIC Educational Resources Information Center

Ratcliff, William C.; Raney, Allison; Westreich, Sam; Cotner, Sehoya

2014-01-01

The evolution of complexity remains one of the most challenging topics in biology to teach effectively. We present a novel laboratory activity, modeled on a recent experimental breakthrough, in which students experimentally evolve simple multicellularity using single-celled yeast ("Saccharomyces cerevisiae"). By simply selecting for…

A Laboratory on Chemotaxonomy: The Systematic Distribution of Betalains.

ERIC Educational Resources Information Center

Daniel, Thomas F.; Johns, Timothy

1982-01-01

Two laboratory procedures in experimental chemotaxonomy are outlined for determining the presence of betalains in genera representing different plant families. A list of materials and equipment needed is provided. (DC)

Optics Recycle Loop Strategy for NIF Operations above UV Laser-Induced Damage Threshold

DOE PAGES

Spaeth, M. L.; Wegner, P. J.; Suratwala, T. I.; ...

2017-03-23

The National Ignition Facility (NIF) at Lawrence Livermore National Laboratory (LLNL) houses the world’s largest laser system, composed of 192 individual, 40-cm-aperture beamlines. The NIF laser routinely operates at ultraviolet (UV) fluences above 8 J/cm 2, more than twice the (3ω only) damage threshold of commercially available UV-grade fused silica. NIF is able to maintain such high fluence operation by using an optics recycling loop strategy. Successful operation of the loop relies on a number of technologies specifically developed for NIF. One of the most important is the capability developed by LLNL and their vendors for producing highly damage-resistant optics.more » Other technologies developed for the optics recycle loop raise the operating point of NIF by keeping damage growth in check. LLNL has demonstrated the capability to sustain UV fused silica optic recycling rates of up to 40 optics per week. The optics are ready for reinstallation after a 3-week trip through a recycle loop where the damage state of each optic is assessed and repaired. The impact of the optics recycle loop has been profound, allowing the experimental program to routinely employ energies and fluences that would otherwise have been unachievable. Without the recycle loop, it is likely that the NIF fluence would need to be kept below the UV threshold for damage growth, ~4 J/cm 2, thus keeping the energy delivered to the target significantly below 1 MJ. With the recycle loop implemented during the National Ignition Campaign, NIF can routinely deliver >1.8 MJ on target, an increase in operational capability of more than 100%. Finally, in this paper, the enabling technological advances, optical performance, and operational capability implications of the optics recycle loop are discussed.« less

Optics Recycle Loop Strategy for NIF Operations above UV Laser-Induced Damage Threshold

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spaeth, M. L.; Wegner, P. J.; Suratwala, T. I.

The National Ignition Facility (NIF) at Lawrence Livermore National Laboratory (LLNL) houses the world’s largest laser system, composed of 192 individual, 40-cm-aperture beamlines. The NIF laser routinely operates at ultraviolet (UV) fluences above 8 J/cm 2, more than twice the (3ω only) damage threshold of commercially available UV-grade fused silica. NIF is able to maintain such high fluence operation by using an optics recycling loop strategy. Successful operation of the loop relies on a number of technologies specifically developed for NIF. One of the most important is the capability developed by LLNL and their vendors for producing highly damage-resistant optics.more » Other technologies developed for the optics recycle loop raise the operating point of NIF by keeping damage growth in check. LLNL has demonstrated the capability to sustain UV fused silica optic recycling rates of up to 40 optics per week. The optics are ready for reinstallation after a 3-week trip through a recycle loop where the damage state of each optic is assessed and repaired. The impact of the optics recycle loop has been profound, allowing the experimental program to routinely employ energies and fluences that would otherwise have been unachievable. Without the recycle loop, it is likely that the NIF fluence would need to be kept below the UV threshold for damage growth, ~4 J/cm 2, thus keeping the energy delivered to the target significantly below 1 MJ. With the recycle loop implemented during the National Ignition Campaign, NIF can routinely deliver >1.8 MJ on target, an increase in operational capability of more than 100%. Finally, in this paper, the enabling technological advances, optical performance, and operational capability implications of the optics recycle loop are discussed.« less

Neutron bursts from long laboratory sparks

NASA Astrophysics Data System (ADS)

Kochkin, P.; Lehtinen, N. G.; Montanya, J.; Van Deursen, A.; Ostgaard, N.

2016-12-01

Neutron emission in association with thunderstorms and lightning discharges was reported by different investigators from ground-based observation platforms. In both cases such emission is explained by photonuclear reaction, since high-energy gamma-rays in sufficient fluxes are routinely detected from both, lightning and thunderclouds. The required gamma-rays are presumably generated by high-energy electrons in Bremsstrahlung process after their acceleration via cold and/or relativistic runaway mechanisms. This phenomenon attracted moderate scientific attention until fast neutron bursts (up to 10 MeV) from long 1 MV laboratory sparks have been reported. Clearly, with such relatively low applied voltage the electrons are unable to accelerate to the energies required for photo/electro disintegration. Moreover, all known elementary neutron generation processes are not capable to explain this emission right away. We performed an independent laboratory experiment on long sparks with the aim to confirm or disprove the neutron emission from them. The experimental setup was assembled at High-Voltage Laboratory in Barcelona and contained a Marx generator in a cone-cone spark gap configuration. The applied voltage was as low as 800 kV and the gap distance was only 60 cm. Two ns-fast cameras were located near the gap capturing short-exposure images of the pre-breakdown phenomenon at the expected neutron generation time. A plastic scintillation detector sensitive to neutrons was covered in 11 cm of lead and placed near the spark gap. The detector was calibrated and showed good performance in neutron detection. Apart of it, voltage, currents through both electrodes, and three X-ray detectors were also monitored in sophisticated measuring system. We will give an overview of the previous experimental and theoretical work in this topic, and present the results of our new experimental campaign. The conclusions are based on good signal-to-noise ratio measurements and are

Women's technical and professional symposium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Budil, K; Mack, L

1999-10-01

This is the fourth LLNL-sponsored Women's Technical and Professional Symposium. This year's theme: ''Excellence through the Millennium,'' focuses on the cutting edge work being done at LLNL and the many contributions of women to our science and technology mission. We hope this Symposium gives each person attending a better idea of the broad scope of the Laboratory's mission and their place within the organization. It is easy to lose sight of the fact that we all work in support of science and technology despite the diversity of our experience. This Symposium provides an opportunity to reflect on our past andmore » to begin to plan our future.« less

2004 Annual Health Physics Report for the HEU Transparency Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Radev, R

2005-04-01

During the 2004 calendar year, LLNL provided health physics support for the Highly Enriched Uranium Transparency Implementation Program (HEU-TIP) in external and internal radiation protection and technical expertise into matters related to BDMS radioactive sources and Russian radiation safety regulatory compliance. For the calendar year 2004, there were 200 person-trips that required dose monitoring of the U.S. monitors. Of the 200 person-trips, 183 person-trips were SMVs and 17 person-trips were Transparency Monitoring Office (TMO) trips. Eight person-trips from the SMV trips were continuation trips of TMO monitors to facilities other than UEIP. The LLNL Safety Laboratories' Division provided the dosimetrymore » services for the HEU-TIP monitors.« less

Mosaic Transparent Armor System Final Report CRADA No. TC02162.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuntz, J. D.; Breslin, M.

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and The Protective Group, Inc. (TPG) to improve the performance of the mosaic transparent armor system (MTAS) for transparent armor applications, military and civilian. LLNL was to provide the unique MTAS technology and designs to TPG for innovative construction and ballistic testing of improvements needed for current and near future application of the armor windows on vehicles and aircraft. The goal of the project was to advance the technology of MTAS to the point that these mosaic transparent windowsmore » would be introduced and commercially manufactured for military vehicles and aircraft.« less

Creating a Tiny Human Body on a Chip

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunsberger, Maren; Soscia, Dave; Moya, Monica

LLNL science communicator Maren Hunsberger takes us "Inside the Lab" to learn about the iChip (In-vitro Chip-based Human Investigational Platform) project at Lawrence Livermore National Laboratory. "One application of the iChip system would be to develop new pharmaceutical drugs," explains Dave Soscia, LLNL postdoc. "When you test in a mouse for example, it's not as close to the human system as you can get. If we can take human cells and put them on devices and actually mimic the structure and function of the organ systems in the human, we can actually replace animal testing and even make a bettermore » system for testing pharmaceutical drugs."« less

Space Radiation Effects Laboratory

NASA Technical Reports Server (NTRS)

1969-01-01

The SREL User's Handbook is designed to provide information needed by those who plan experiments involving the accelerators at this laboratory. Thus the Handbook will contain information on the properties of the machines, the beam parameters, the facilities and services provided for experimenters, etc. This information will be brought up to date as new equipment is added and modifications accomplished. This Handbook is influenced by the many excellent models prepared at other accelerator laboratories. In particular, the CERN Synchrocyclotron User's Handbook (November 1967) is closely followed in some sections, since the SREL Synchrocyclotron is a duplicate of the CERN machine. We wish to thank Dr. E. G. Michaelis for permission to draw so heavily on his work, particularly in Section II of this Handbook. We hope that the Handbook will prove useful, and will welcome suggestions and criticism.

EPOS-WP16: A Platform for European Multi-scale Laboratories

NASA Astrophysics Data System (ADS)

Spiers, Chris; Drury, Martyn; Kan-Parker, Mirjam; Lange, Otto; Willingshofer, Ernst; Funiciello, Francesca; Rosenau, Matthias; Scarlato, Piergiorgio; Sagnotti, Leonardo; W16 Participants

2016-04-01

The participant countries in EPOS embody a wide range of world-class laboratory infrastructures ranging from high temperature and pressure experimental facilities, to electron microscopy, micro-beam analysis, analogue modeling and paleomagnetic laboratories. Most data produced by the various laboratory centres and networks are presently available only in limited "final form" in publications. As such many data remain inaccessible and/or poorly preserved. However, the data produced at the participating laboratories are crucial to serving society's need for geo-resources exploration and for protection against geo-hazards. Indeed, to model resource formation and system behaviour during exploitation, we need an understanding from the molecular to the continental scale, based on experimental data. This contribution will describe the work plans that the laboratories community in Europe is making, in the context of EPOS. The main objectives are: - To collect and harmonize available and emerging laboratory data on the properties and processes controlling rock system behaviour at multiple scales, in order to generate products accessible and interoperable through services for supporting research activities. - To co-ordinate the development, integration and trans-national usage of the major solid Earth Science laboratory centres and specialist networks. The length scales encompassed by the infrastructures included range from the nano- and micrometer levels (electron microscopy and micro-beam analysis) to the scale of experiments on centimetre sized samples, and to analogue model experiments simulating the reservoir scale, the basin scale and the plate scale. - To provide products and services supporting research into Geo-resources and Geo-storage, Geo-hazards and Earth System Evolution.

Quasi-experimental nonequivalent (pretest and posttest) control-group study of the effects of microcomputer-based laboratory systems on academic achievement in high school chemistry students at two South Carolina high schools

NASA Astrophysics Data System (ADS)

Venables, Jeffrey M.

The literature on microcomputer-based laboratories (MBL) lacks quantitative studies that measure the effect of MBL on student achievement. The purpose of this study was to investigate the effect of MBL systems on the achievement of high school chemistry students. The first research question examined the effect of MBL systems on student achievement in high school chemistry laboratories. The second question analyzed the effect of MBL systems on the academic achievement of students of different genders, ethnicities, and socioeconomic backgrounds. This quasi-experimental quantitative research study evaluated the effects of MBL on student achievement in high school chemistry. The sample consisted of 124 college preparatory chemistry students at two high schools in a South Carolina school district. There were 42 participants in the experimental group and 82 participants in the control group. Both experimental and groups completed a pre- and post-test with MBL being the independent variable. The mean difference score for the experimental group was compared to that of the control group using an independent-measures t test and an analysis of variance. For the second research question, results were analyzed using a two-factor analysis of variance. Participant scores were broken down by gender, ethnicity, and socioeconomic status in order to identify potential differences. The results revealed no significant differences between the experimental and control groups, and no significant differences in effects of MBL on different segments of the population. Future studies should examine students using MBL for longer durations than one unit of study. As society continues to make technological advances, the effective assessment and implementation of technology resources for the classroom are becoming increasingly important.

The COBRA demonstrator at the LNGS underground laboratory

NASA Astrophysics Data System (ADS)

Ebert, J.; Fritts, M.; Gehre, D.; Gößling, C.; Göpfert, T.; Hagner, C.; Heidrich, N.; Klingenberg, R.; Köttig, T.; Kröninger, K.; Michel, T.; Neddermann, T.; Nitsch, C.; Oldorf, C.; Quante, T.; Rajek, S.; Rebber, H.; Reinecke, O.; Rohatsch, K.; Schulz, O.; Sörensen, A.; Stekl, I.; Tebrügge, J.; Temminghoff, R.; Theinert, R.; Timm, J.; Wester, T.; Wonsak, B.; Zatschler, S.; Zuber, K.

2016-01-01

The COBRA demonstrator, a prototype for a large-scale experiment searching for neutrinoless double beta-decay, was built at the underground laboratory Laboratori Nazionali del Gran Sasso (LNGS) in Italy. It consists of an array of 64 monolithic, calorimetric CdZnTe semiconductor detectors with a coplanar-grid design and a total mass of 380 g. It is used to investigate the experimental challenges faced when operating CdZnTe detectors in low-background mode, to identify potential background sources and to show the long-term stability of the detectors. The first data-taking period started in 2011 with a subset of the detectors, while the demonstrator was completed in November 2013. To date, more than 250 kg d of data have been collected. This paper describes the technical details of the experimental setup and the hardware components.

Comparative Cognitive Task Analyses of Experimental Science and Instructional Laboratory Courses

NASA Astrophysics Data System (ADS)

Wieman, Carl

2015-09-01

Undergraduate instructional labs in physics generate intense opinions. Their advocates are passionate as to their importance for teaching physics as an experimental activity and providing "hands-on" learning experiences, while their detractors (often but not entirely students) offer harsh criticisms that they are pointless, confusing and unsatisfying, and "cookbook." Here, both to help understand the reason for such discrepant views and to aid in the design of instructional lab courses, I compare the mental tasks or types of thinking ("cognitive task analysis") associated with a physicist doing tabletop experimental research with the cognitive tasks of students in an introductory physics instructional lab involving traditional verification/confirmation exercises.

Enabling UAS Research at the NASA EAV Laboratory

NASA Technical Reports Server (NTRS)

Ippolito, Corey A.

2015-01-01

The Exploration Aerial Vehicles (EAV) Laboratory at NASA Ames Research Center leads research into intelligent autonomy and advanced control systems, bridging the gap between simulation and full-scale technology through flight test experimentation on unmanned sub-scale test vehicles.

Designing and Implementing a Constructivist Chemistry Laboratory Program.

ERIC Educational Resources Information Center

Blakely, Alan

2000-01-01

Describes a constructivist chemistry laboratory approach based on students' personal experiences where students had the opportunity to develop their own experimental processes. Points out both the fruitfulness and difficulties of using a graduate student as a teaching assistant. (YDS)