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Nam Con Son Basin  

Microsoft Academic Search

The Nam Con Son basin is the largest oil and gas bearing basin in Vietnam, and has a number of producing fields. The history of studies in the basin can be divided into four periods: Pre-1975, 1976-1980, 1981-1989, and 1990-present. A number of oil companies have carried out geological and geophysical studies and conducted drilling activities in the basin. These

N. T. Tin; N. D. Ty; L. T. Hung



The Con Test  

ERIC Educational Resources Information Center

|In this article, the author describes the format of the Con Test, an Australian television game show which followed the same general rules and game play as the UK show PokerFace. At the end of each round a contestant needs to decide whether or not he or she should fold. A contestant needs to know how likely it is that he or she is in last place.…

Fletcher, Michael




Center for Food Safety and Applied Nutrition (CFSAN)

Text Version... 160°F Pavo, Pollo 165°F CARNE FRESCAS DE RES, CERDO, TERNERA, CORDERO 145°F con 3 minutos de descanso CARNE DE AVE ... More results from


Synthetic slings: pros and cons.  


Historically, the choice of sling material for the treatment of urinary incontinence has been based on the surgeon's preference and experience. In general, pelvic surgeons have not differentiated artificial graft materials by their inherent qualities or for biocompatibility in the female pelvis and vaginal wall. The introduction of new artificial graft materials and new methods of implantation for the correction of genuine stress incontinence has generated renewed interest in the "pros and cons" associated with nonabsorbable material use. In this review, we discuss and differentiate sling materials and techniques. We consider some of the physical and biologic qualities of artificial graft materials, present theories and practices associated with the successful use of permanent grafts, and discuss the natural evolution of artificial graft slings to the current use of the tension-free vaginal tape and Suprapubic Arc Sling System (American Medical Systems, Minneapolis, MN). PMID:12354353

Staskin, David R; Plzak, Louis



¡Truco Con Agua!  

NSDL National Science Digital Library

En esta actividad los aprendices aprenderán un truco de magia donde la magia es la presión del aire. Los participantes tomarán un vaso de agua medio lleno y lo taparán con un pedazo de plástico o cartón. Sosteniendo la tarjeta contra el vaso, lo voltearán boca abajo y cuando quiten la mano debajo del vaso, ¡abracadabra! no se caerá el agua. En la tira cómica, Mateo explica a los aprendices que la presión que hace el aire en todas las direcciones es la que sostiene la tarjeta.

Science, Lawrence H.



Genetic polymorphism of CON 1 and CON 2 salivary proteins detected by immunologic and concanavalin a reactions on nitrocellulose with linkage of CON 1 and CON 2 genes to the SPC (salivary protein gene complex)  

Microsoft Academic Search

Two new genetic protein polymorphisms (CON 1 and CON 2) were identified in parotid saliva. Genetic polymorphisms of salivary CON 1 (concanavalin A) and CON 2 proteins are determined by autosomal inheritance of one expressed (dominant) and one unexpressed (recessive) allele for each gene. Autosomal inheritance is supported by studies in 26 families including 105 children for CON 1 and

Edwin A. Azen; Pao-Lo Yu



Automedicarse con antibióticos puede perjudicar su salud  

Center for Drug Evaluation (CDER)

... Automedicarse con antibióticos puede perjudicar su salud. (poster). ... Consulte a su médico oa un profesional de la salud antes de usar antibióticos. ... More results from


Automedicarse con antibióticos puede perjudicar su salud ...  

Center for Drug Evaluation (CDER)

... Automedicarse con antibióticos puede perjudicar su salud (PSA). ... Consulte a su médico oa un profesional de la salud antes de usar antibióticos. ... More results from


The Pros and Cons of Artificial Reefs  

NSDL National Science Digital Library

This lesson plan asks students to consider whether artificial reefs (human-made objects in the ocean or sea) are good for marine ecosystems. Students will look at pictures of artificial reefs and read articles describing the pros and cons of these structures. They will conclude by writing paragraphs explaining whether they think a new artificial reef should be created in Florida waters.


The pros and cons of hospital employment.  


The pros and cons of hospital employment vary significantly in today's economic environment. This chapter summarizes the advantages and disadvantages of hospital employment with an emphasis on the critical aspect of formalizing an agreement with the hospital employer to prevent future salary reductions and/or termination. PMID:23924751

Bert, Jack M



Google Scholar: the pros and the cons  

Microsoft Academic Search

Purpose – To identify the pros and the cons of Google Scholar. Design\\/methodology\\/approach – Chronicles the recent history of the Google Scholar search engine from its inception in November 2004 and critiques it with regard to its merits and demerits. Findings – Feels that there are massive content omissions presently but that, with future changes in its structure, Google Scholar

Péter Jacsó



InterCon Travel Health: Case B  

ERIC Educational Resources Information Center

|InterCon provides services to health insurers of foreign tourists who travel to the United States and Canada. Management wants to implement a new information system that will deal with several operational problems, but it is having difficulty securing the capital resources to fund the system's development. After an initial failure, the chief…

Truman, Gregory E.; Pachamanova, Dessislava A.; Goldstein, Michael A.



InterCon Travel Health: Case B  

ERIC Educational Resources Information Center

InterCon provides services to health insurers of foreign tourists who travel to the United States and Canada. Management wants to implement a new information system that will deal with several operational problems, but it is having difficulty securing the capital resources to fund the system's development. After an initial failure, the chief…

Truman, Gregory E.; Pachamanova, Dessislava A.; Goldstein, Michael A.



Somatic cell nuclear transfer: pros and cons.  


Even though the technique of mammalian SCNT is just over a decade old it has already resulted in numerous significant advances. Despite the recent advances in the reprogramming field, SCNT remains the bench-mark for the generation of both genetically unmodified autologous pluripotent stem cells for transplantation and for the production of cloned animals. In this review we will discuss the pros and cons of SCNT, drawing comparisons with other reprogramming methods. PMID:20232594

Sumer, Huseyin; Liu, Jun; Tat, Pollyanna; Heffernan, Corey; Jones, Karen L; Verma, Paul J




Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey



9 CFR 319.301 - Chili con carne with beans.  

Code of Federal Regulations, 2010 CFR

... 2010-01-01 2010-01-01 false Chili con carne with beans. 319.301 Section 319.301...Dehydrated Meat Food Products § 319.301 Chili con carne with beans. Chili con carne with beans shall contain not less...



9 CFR 319.301 - Chili con carne with beans.  

Code of Federal Regulations, 2010 CFR

... 2009-01-01 2009-01-01 false Chili con carne with beans. 319.301 Section 319.301...Dehydrated Meat Food Products § 319.301 Chili con carne with beans. Chili con carne with beans shall contain not less...



Jugando con geometría: Crear secuencias con formas y palabras  

NSDL National Science Digital Library

En esta actividad, los chicos crean secuencias con palabras y formas. Los chicos usan colecciones de triángulos, cuadrados, y rectángulos con palabras adentro. Los chicos organizan las forman en secuencias geométricas que se repiten o que cambian de manera sistemática en cada línea. Los chicos más jóvenes pueden crear secuencias simples; los mayores pueden explorar secuencias que crecen de diferentes maneras. Esta actividad tiene colecciones de palabras en tres niveles de dificultad diferente. Disponible en formato Web y PDF. También disponible en Inglés.





Microsoft Academic Search

RESUMEN Se establece, en una primera aproximación, el óptimo de cobertura en función de las pér- didas de suelo por erosión hídrica y de las pérdidas de lluvia por interceptación, en un mato- rral (romeral), en condiciones ambientales semiáridas mediterráneas, con un mismo tipo de suelo y dos tramos de pendiente de ladera, 11% y 25%. Se utiliza el promedio

Belmonte Serrato; Romero Díaz; López Bermúdez; E. Hernández Laguna


Pros and cons of phage therapy  

PubMed Central

Many publications list advantages and disadvantages associated with phage therapy, which is the use of bacterial viruses to combat populations of nuisance or pathogenic bacteria. The goal of this commentary is to discuss many of those issues in a single location. In terms of “Pros,” for example, phages can be bactericidal, can increase in number over the course of treatment, tend to only minimally disrupt normal flora, are equally effective against antibiotic-sensitive and antibiotic-resistant bacteria, often are easily discovered, seem to be capable of disrupting bacterial biofilms, and can have low inherent toxicities. In addition to these assets, we consider aspects of phage therapy that can contribute to its safety, economics, or convenience, but in ways that are perhaps less essential to the phage potential to combat bacteria. For example, autonomous phage transfer between animals during veterinary application could provide convenience or economic advantages by decreasing the need for repeated phage application, but is not necessarily crucial to therapeutic success. We also consider possible disadvantages to phage use as antibacterial agents. These “Cons,” however, tend to be relatively minor.

Loc-Carrillo, Catherine



The 2009 Astrobiology Graduate Student Conference (AbGradCon)  

NASA Astrophysics Data System (ADS)

The 2009 AbGradCon was held at the University of Washington in July 2009. It brought together 67 participants from 8 different countries and 34 different universities. AbGradCon also took place in the virtual world of Second Life.

Som, S. M.; Anderson, R.; Antonio, M.; Cash, M. C.; Claire, M.; Cowan, N.; Ewert, M.; Goldman, A.; Snowden, D.; Stüeken, E.



A ConA-like lectin from Dioclea guianensis Benth. has antifungal activity against Colletotrichum gloeosporioides, unlike its homologues, ConM and ConA.  


This study reports on the antifungal activity of Dgui, a ConA-like lectin from Dioclea guianensis seeds. Dgui inhibited conidial germination but not mycelial growth of Colletotrichum gloeosporioides. The lectins ConA and ConM from Canavalia ensiformis and Canavalia maritima, respectively, share high levels of amino acid sequence similarity (>84%) with Dgui and have the same specificity toward glucose/mannose but had no effect on the fungus. Fluorescence microscopy showed that both Dgui and ConM bind to C. gloeosporioides ungerminated conidia. However, Dgui did not bind to C. gloeosporioides germinated conidia and germ tubes and was not inhibitory to mycelial growth. Because only Dgui inhibited germination of the fungus, C. gloeosporioides conidia might have surface-specific germination targets recognized by Dgui but not by its homologues, ConM and ConA. Therefore, Dgui is a candidate for biotechnological approaches for improving the resistance of various nutritionally and commercially important crops that are affected by C. gloeosporioides. PMID:20201549

Araújo-Filho, José H; Vasconcelos, Ilka M; Martins-Miranda, Aparecida S; Gondim, Darcy M F; Oliveira, José T A



Cálculos ab initio con correlación electrónica  

NASA Astrophysics Data System (ADS)

Estamos entrando en una era donde la ortogonalidad entre las investigaciones de carácter experimental y de naturaleza teórica se irá difuminando progresivamente y la problemática a resolver quedará en escena como el único actor principal de la obra. Como premisa para una cooperación teórico-experimental de igual a igual, la metodología químico-cuántica utilizada debe ser capaz de ofrecer resultados de carácter predictivo. Sin duda, esta madurez en la metodología químico-cuántica ya la hemos alcanzado hace algunos años, tal y como muestra entre otras muchas, la labor que nuestro grupo ha realizado en el transcurso de la última década, dentro del campo de la Espectroscopía Teórica. Los estudios realizados comprenden una amplia gama de sistemas, variando tanto en tamaño como en complejidad, abordando problemáticas espectroscópicas consideradas tradicionalmente como especialmente controvertidas. Nuestra contribución científica más relevante reside en el carácter cuantitativo de las asignaciones espectroscópicas que hemos propuesto en base a resultados ab initio. Recordemos que en los años noventa los resultados ab initio solían presentar para las energías de excitación de sistemas de tamaño molecular moderado, como el benceno, errores de más de 1 eV. En comparación con el éxito relativo de los métodos semiempíricos, la frustración de la metodología ab initio quedaba todavía más patente. Los estudios que hemos presentado representan una comprensión profunda de los espectros electrónicos en sistemas orgánicos claves, mostrando el camino a seguir para obtener asignaciones espectroscópicas precisas (entre 0.1-0.2 eV). La naturaleza del método CASPT2 junto al diseño de estrategias computacionales nos ha permitido alcanzar el carácter cuantitativo con el que se caracterizan nuestras contribuciones[1,2]. Por todo ello, algunos de los trabajos publicados se consideran clásicos dentro del campo, pues en cierto modo definen el campo, y se reflejan en libros publicados recientemente. En la conferencia se analizarán ciertos pormenores de las investigaciones realizadas. El tipo de aplicaciones llevadas a cabo hasta la fecha se ilustrará mediante el estudio teórico del espectro electrónico de ciclooctatetraeno. Dando un paso más en la evolución de nuestra investigación, pretendemos en la actualidad describir, desde un formalismo teórico y al mismo nivel de exigencia, los mecanismos subyacentes que tienen lugar en las reacciones biológicas fototoinducidas, es decir, reacciones que se inician mediante la absorción de luz[3]. Como muestra de la caracterización de los procesos fotofísicos y fotoquímicos en fotobiología teórica, hemos elegido la descripción de la conversión interna ultrarrápida que tiene lugar en los cromóforos del ADN. Los estados excitados de las moléculas de los ácidos nucleicos presentan tiempos de vida media que se encuentran en el rango de sub-picosegundos, sugiriendo la presencia de un canal ultrarrápido de conversión interna, lo que normalmente se asocia en la fotoquímica contemporánea a una intersección cónica entre el estado excitado y el fundamental[4]. De esta forma nuestro ADN previene de forma eficaz posibles reacciones en el estado excitado y se revela como un excelente protector solar.

Merchán Bonete, M.


Pro/con a precessional geodynamo  

NASA Astrophysics Data System (ADS)

The modest amount of research that exists on the ability, or lack of ability, of mantle precession to power a geodynamo developed mostly during the last half of the 1900s. Papers by Roberts and Stewartson (1965) and by Busse (1968) studied precession generally without a pro/con conclusion. Malkus in the late 1960s attempted to advance a positive role for precession through experiments and analysis. His experiments have survived criticism, but his analyses were discounted, especially by Rochester, Jacobs, Smylie, and Chong (1975) and by Loper (1975). Rochester, et al. critiqued existing analyses of precession, including those of Malkus, but did not reach a strong position either pro or con a precessional geodynamo. Loper argued emphatically that precession was not capable of powering the geodynamo. Explicit analyses that either critique or support Loper’s arguments have yet to appear in the literature. During the 1970s, Vanyo and associates studied energy dissipation during precession of satellite liquid fuels and its effect on satellite attitude stability. Engineers and scientists in every country that has launched satellites completed similar research. Some is published in the aerospace literature, more is available in company and government reports. Beginning in 1981, Vanyo and associates applied this knowledge to the very similar problem of energy dissipation and flow patterns in precessing mechanical models scaled geometrically and dynamically to the Earth’s liquid core. Energy experiments indicate massive amounts of mechanical energy are dissipated at the CMB, and flow experiments show complex motions within the boundary layer and axial flows with helicity throughout the interior. Analysis of Earth core precession also advanced, especially in several papers by Kerswell and by Tilgner in the late 1990s. Detail numerical models have yet to appear. Although progress in understanding the role of precession in Earth core motions has advanced, there remains a common belief, often expressed explicitly, that precession is incapable of energizing a geodynamo, a la Loper. We will present a critique of Loper’s 1975 paper and briefly discuss the common practice and belief that the geodynamo must be energized by thermal and/or compositional driven convection (motion). We note here that there is no observational evidence for existence of thermal or compositional convection within the liquid core or for growth of the solid core. Although there has been considerable success in adapting data in thermal/compositional models to yield near realistic solutions, that does not constitute a proof that those models apply to the Earth. There is absolute observational evidence for mantle precession, an Earth feature that is unique, along with the Earth’s magnetic field, among the terrestrial planets. We argue that great difficulty experienced in analysis and computation of precessional flow is a major explanation for its absence in current models of the geodynamo.

Vanyo, J.



Television and Children: A Pro/Con Reading List.  

ERIC Educational Resources Information Center

Lists books, audiovisual materials, newspaper articles, pamphlets, government documents, and periodical articles on the effects of television on children. Divided into sections on pro and con sources, the 53 annotated items are arranged by type of material. (BK)

Erbeck, Diane M.



Compositional Quality Control Study of CON-2 Glass.  

National Technical Information Service (NTIS)

A statiscal strategy was used to select experiments to determine how commonly measured physical properties of CON-2 glass vary with composition. The physical properties explored in the study included density, dilatometric softening temperature, thermal ex...

C. Nelson E. V. Thomas P. R. Wengert



Breath analysis science at PittCon 2012, Orlando, Florida  

Microsoft Academic Search

BackgroundBreath analysis science was featured in three organized sessions at this year's Pittsburgh Conference and Exposition, or 'PittCon 2012' (http:\\/\\/\\/). As described in previous meeting reports, PittCon is one of the largest international conferences for analytical chemistry and instrumentation, typically attracting about 20 000 attendees and 1000 commercial exhibitors (Pleil 2010, 2011). This year the conference was held in Orlando,

Joachim D Pleil; Matthew A Stiegel; Tzipporah M Kormos; Jon R Sobus



Análisis de la susceptibilidad a los movimientos de ladera en la cuenca del río Llaminchán (Cajamarca, Perú)  

Microsoft Academic Search

The Llaminchan basin is located in the Western Cordillera of northern of Peru, within the Cajamarca region. The analysis using Geographic Information Systems of the mapping and inventory of slope movements, the topography, litology, hydrogeology applied to the Llaminchan Basin, allows obtaining the map of susceptibility to slope movements. It is show that the zones with greater susceptibility are to

Sandra Villacorta; Miguel Llorente; Luis Laín; Lionel Fidel; José Machare; Victor Carlotto


Paramagnetic-to-Ferromagnetic Transition in Con Under Pressure  

NASA Astrophysics Data System (ADS)

Motivated by reports of synthesis of zincblende (ZB) structure CrAs in thin film form, strong interest has developed in understanding transition metal pnictides and their tendencies toward magnetic order.Literature on the experimental analysis of the structure of CoN is varied, with reports of both magnetically ordered NaCl structure CoN and non-magnetic ZB CoN. We present results of first principles analysis of electronic structure, magnetism and Murnaghan equation of state for both structures. The non-magnetic ZB structure, stable at ambient pressure transforms to a collapsed ferromagnetic NaCl phase at 10GPa (?V = -15%). These results will be compared to data and similarities/differences with other transition metal nitrides will be discussed.

Kasinathan, Deepa; Pickett, Warren



La fotoscintigrafia con Hg 203 e Tc 99 nella diagnosi delle lesioni cerebrali  

Microsoft Academic Search

Riassunto Gli AA presentano i risultati ottenuti con la fotoscintigrafia con Hg203 e Tc99 in 244 casi. Dopo aver osservato l'elevata positività con cui vengono diagnosticati i tumori cerebrali (64 casi su 65), gli autori considerano come sia più difficile con la scintigrafia rispetto alla gammaencefalografia porre una diagnosi di natura del tumore. I risultati positivi ottenuti nelle lesioni espansive

A. Agnoli; C. Fieschi; L. Bozzao; A. Bartolini



Aminoacidi liberi plasmatici nel diabetico dopo trattamento con insulina ed ipoglicemizzante orale  

Microsoft Academic Search

Riassunto In 30 pazienti diabetici (15 maschi e 15 femmine) sono stati determinati gli aminoacidi liberi plasmatici dopo trattamento con insulina (20 casi) e con ipoglicemizzante orale (10 casi), a compenso clinico e metabolico raggiunto. Il confronto statistico con i dati rilevati prima del trattamento terapeutico e con quelli relativi a 30 soggetti normali ha evidenziato l'azione «mirata» dell'insulina esogena,

Alberto M. Bertolini; Arturo Santagostino



Investigación Estudio sistematizado de familias con adolescentes y estilos de vida saludable  

Microsoft Academic Search

Al sistematizar la experiencia realizada junto a fami- lias con adolescentes, para construir con esta población estilos de vida saludable que favorecieran el crecimiento y desarrollo de los y las adolescentes, se relacionaron los procesos inmediatos y el quehacer con su contexto; a la vez, se confrontó dicho quehacer con los supuestos teóricos que los inspiraron. Se sustentó la experiencia


Caracterización de tintas de titanio dopadas con óxidos metálicos  

Microsoft Academic Search

Se prepararon tintas de Diisopropoxido de titanio bis(acetilacetonato) por el método sol-gel para aplicar en la elaboración de nanoestructuras mediante la técnica de escritura directa. Esta técnica permite estructurar materiales con alto índice de refracción a escala micro y nanométrica en tres dimensiones mediante extrusión, para elaborar cristales fotónicos. El tratamiento de las nanoestructuras extruidas a temperaturas elevadas para transformarlas



Exact Solutions of Diusion-Con vection Equations  

Microsoft Academic Search

In the presented paper known (up to the beginning of 2008) Lie- and non-Lie exact solutions of dieren t (1+1)-dimensional diusion{con vection equations of form f(x)ut = (g(x)A(u)ux)x + h(x)B(u)ux are collected.

Nataliya M. Ivanova



Pros and Cons of Part-Time Faculty.  

ERIC Educational Resources Information Center

A study of the pros and cons of part-time faculty shows that about one-third of all college faculty are part-time. They cost less, and are a valuable asset to a school, but may cause accrediting problems if they number more than 25 percent of the total faculty. (JMF)

AGB Reports, 1979



Desarrollo y transferencia tecnológica de pastas funcionales extendidas con leguminosas  

Microsoft Academic Search

RESUMEN. La pasta de sémola es un alimento altamente consumido, cuyo valor biológico es bajo porque su proteína es deficiente en lisina. Sin embargo, si se extiende la sémola con leguminosas ricas en este aminoácido esencial, no sólo se produce una complementación aminoacídica, sino que se incrementa el contenido de fibra dietética y de minerales. En este trabajo se produjeron

Marisela Granito; Vanesa Ascanio


Reputation, Social Identity and Social Con‡ict  

Microsoft Academic Search

We interpret the psychology literature on social identity and examine its implications in a population partially composed of such agents. We model a population of agents from two exogenous and well de…ned social groups. Agents are randomly matched to play a reduced form bargaining game. We show that this struggle for resources drives a con‡ict through the rational destruction of

John Smithy


SatisfacciÛn marital en pacientes con artritis reumatoide. Estudio comparativo con otras enfermedades crÛnicas y controles sanos  

Microsoft Academic Search

SUMMARY Objective: to assess marital satisfaction (MS) in patients with rheumatoid arthritis (RA) and com- pare it with other chronic diseases and normal con- trols. Material and methods: we studied 50 patients with RA and compared them with 50 patients with systemic lupus erythematosus (SLE), 50 patients with diabetes mellitus (type 2), and 50 normal controls. We applied a marital

Barile Fabris


The king of Comic-Con [Geek life  

Microsoft Academic Search

The last thing you want to do is rankle a group of Star Wars stormtroopers. The annual geekfest known as Comic-Con International is not only a four-day exploration of the intersection of science fiction, comics, science, and pop culture; with 125,000 attendees, it's one of the largest conventions in the world, requiring heroic feats of engineering to keep the lines

Susan Karlin



Neogene sequence stratigraphy, Nam Con Son Basin, offshore Vietnam  

Microsoft Academic Search

An integrated well log, biostratigraphic, and seismic stratigraphic study of Miocene to Recent deltaic sediments deposited in the Nam Con Son Basin offshore from southern Vietnam shows the influence of eustacy and tectonics on sequence development. Sediments consist of Oligocene non-marine rift-basin fill (Cau Formation), early to middle Miocene tide-dominated delta plain to delta front sediments (TB 1.5 to TB

K. J. McMillen; E. K. Lee; S. S. Hong



A new compound, Ca3CoN3, with a trigonal planar [CoN3]6- anion  

NASA Astrophysics Data System (ADS)

A new compound, Ca3CoN3, was prepared in a reaction of Ca3N2 and cobalt fine powder under a nitrogen stream at 1000°C. It has a monoclinic unit cell with a = 6.308 Å, b = 5.137 Å, c = 5.933 Å, and ? = 75.1°. It is not isostructural with other A3MN3 but has a closely related structure with a trigonal planar [MN3]6- structural unit where A is an alkaline-earth metal and M = V, Cr, Fe. The Co3+ is assumed to be in a low spin d6 state and to be coordinated by three nitrogen atoms accepting nitrogen's 2p electrons to their d2s hybridized orbitals. Ca3CoN3 is nonmagnetic and semiconducting with a room temperature resistivity of 2.6 x 102 ? cm and with an activation energy of 0.02 eV.

Yamamoto, T.; Kikkawa, S.; Kanamaru, F.



Reputation Social Identity and Social Con‡ict  

Microsoft Academic Search

Abstract We interpret the psychology,literature on social identity and examine,its implications in a population,partially composed,of such agents. We model,a population,of agents from two,exogenous,and,well de…ned social groups. Agents are randomly,matched,to play a reduced,form bargaining,game.,We show,that this struggle for resources drives a con‡ict through,the rational destruction,of surplus. We assume,that the population contains both,rational players and behavioral,players. Behavioral players aggressively discriminate,against members,of the

John Smith


RoboCon: Operator interface for robotic applications  

SciTech Connect

Carnegie Mellon U. and ORNL`s Robotics and Process Systems Division are developing a state-of-the-art robot operator control station (RoboCon) with standardized hardware and software control interfaces to be adaptable to a variety of remote and robotic equipment currently funded by DOE`s Office of Science & Technology Robotics Technology Development Program. The human operation and telerobotic and supervisory control of sophisticated and remote and robotic systems is a complex, tiring, and non-intuitive activity. Since decontamination & decommissioning, selective equipment removal, mixed waste operations, and in-tank cleanup are going to be a major future activity in DOE environmental restoration and waste management cleanup agenda, it seems necessary to utilize an operator control station and interface which maximizes operator comfort and productivity.

Schempf, H.; Warwick, J.; Fung, M.; Chemel, B.; Blackwell, M.



Neogene sequence stratigraphy, Nam Con Son Basin, offshore Vietnam  

SciTech Connect

An integrated well log, biostratigraphic, and seismic stratigraphic study of Miocene to Recent deltaic sediments deposited in the Nam Con Son Basin offshore from southern Vietnam shows the influence of eustacy and tectonics on sequence development. Sediments consist of Oligocene non-marine rift-basin fill (Cau Formation), early to middle Miocene tide-dominated delta plain to delta front sediments (TB 1.5 to TB 2.5, Due and Thong Formations), and late Miocene to Recent marine shelf sediments (TB. 2.6 to TB 3.1 0, Mang Cau, Nam Con Son, and Bien Dong Formations). Eustacy controlled the timing of key surfaces and sand distribution in the tectonically-quiet early Miocene. Tectonic effects on middle to late Miocene sequence development consist of thick transgressive systems tracts due to basin-wide subsidence and transgression, sand distribution in the basin center, and carbonate sedimentation on isolated fault blocks within the basin. Third-order sequence boundaries (SB) are identified by spore peaks, sand stacking patterns, and channel incision. In the basin center, widespread shale beds with coal occur above sequence boundaries followed by transgressive sandstone units. These TST sandstones merge toward the basin margin where they lie on older HST sandstones. Maximum flooding surfaces (MFS) have abundant marine microfossils and mangrove pollen, a change in sand stacking pattern, and often a strong seismic reflection with downlap. Fourth-order genetic-type sequences are also interpreted. The MFS is the easiest marker to identify and correlate on well logs. Fourth-order SB occur within these genetic units but are harder to identify and correlate.

McMillen, K.J. (Beaver Creek Tech. Co., Mason, TX (United States)); Do Van Luu; Lee, E.K.; Hong, S.S. (PEDCO, Ho Chi Minh City (Viet Nam))



Gleevec disminuye la recidiva del cáncer en pacientes con tumor estromal gastrointestinal primario

Los resultados preliminares de un estudio clínico grande aleatorio y controlado con placebo, en pacientes con tumor estromal gastrointestinal (GIST) primario, un tipo de tumor que por lo general se encuentra en el estómago o en el intestino delgado, demostraron que los pacientes a los que se administró mesilato de imatinib (Gleevec®) luego de la extirpación total de su tumor tuvieron una probabilidad significativamente menor de padecer una recidiva del cáncer en comparación con aquellos a los que no se administró imatinib.


Niveles Plasmáticos de Insulina y Glucosa en Diabéticos Tratados con Glibenclamida y Clorpropamida  

Microsoft Academic Search

Riassunto  Sono stati studiati due gruppi di pazienti con diabete stabile dell’età matura, ciascuno costituito da 4 soggetti: il primo\\u000a (gruppo « A ») era stato trattato con glibenclamide durante 20,0 ± 1,1 mesi, il secondo (gruppo « B »), con clorpropamide\\u000a durante 44,2 ± 15,4 mesi. Dopo 3 determinazioni preliminari della glicemia (metodo di Somogyi-Nelson) e dell’insulinemia (metodo\\u000a di Meade

Carlos Aiello; Diego Turner; Néstor J. I. Aparicio; Elda A. de Turner; Alberto Vazquez



Light and Developmental Regulation of the Gene con-10 of Neurospora crassa  

Microsoft Academic Search

The gene con-10 of Neurospora crassa is expressed preferentially during conidiation and following illumination of vegetative mycelia with blue light. In this study we have examined the segmental locations of the genetic elements associated with con-10 that are responsible for light and developmental expression. A translational fusion was prepared between the initial segment of con-10 and Escherichia coli lacZ. Deletions

Luis M. Corrochano; Frank-Roman Lauter; Daniel J. Ebbole; Charles Yanofsky



Performance of the RespiCon personal aerosol sampler in forest products industry workplaces.  


The RespiCon is a multistage virtual impactor that can be used as either a personal or an area sampler. Particles collected on the first stage of the RespiCon represent the respirable fraction of airborne particulate matter. Particles collected on the first and second stages represent the thoracic fraction, and particles collected on the first, second, and third stages represent the inhalable fraction. The RespiCon is available in two versions, one with photometric aerosol detection and a gravimetric version. In this study, the performance of the gravimetric version was examined in various forest products industry facilities. The precision of the RespiCon was assessed and its performance was compared with that of both a respirable cyclone and an inhalable dust sampler. In addition, some RespiCon samples were examined using scanning electron microscopy to determine physical particle size distribution. Under the conditions of this testing, the RespiCon appeared to be reasonably precise. For most sampling locations there was a close correspondence between measurements made with the RespiCon and the CIS personal inhalable sampler or the BGI-4 respirable cyclone. The results of microscopic examination of filters from the RespiCon were consistent with expected performance characteristics. The RespiCon is a useful sampling device for those situations in which it is important to simultaneously collect either personal or area samples of the respirable, thoracic, and inhalable fractions of airborne particulate matter. PMID:12173181

Tatum, Vickie; Ray, Alison E; Rovell-Rixx, David


Pros and Cons of Medical Management of Ulcerative Colitis  

PubMed Central

Ulcerative colitis (UC) is a chronic inflammatory disease characterized by diffuse mucosal inflammation limited to the colon and rectum. Although a complete medical cure may not be possible, UC can be treated with medications that induce and maintain remission. The medical management of this disease continues to evolve with a goal to avoid colectomy and ultimately alter the natural history of UC. Emergence of antitumor necrosis factor-? (TNF-?) agents has expanded the medical armamentarium. 5-Aminosalicylates continue to be used in mild to moderate UC and corticosteroids are mainly used for induction of remission with immunomodulators (6-mercaptopurine/azathiopurine/methotrexate) being applied as steroid-sparing agents for maintenance therapy. Infliximab has been approved by the U.S. Food and Drug Administration and used in the treatment of moderate to severe UC; nevertheless, its use may be associated with significant adverse effects and have a negative impact on the postoperative course should the patients undergo restorative proctocolectomy. In addition, there is always a concern about patients' compliance to medical therapy, cost of medications, and risk for UC-associated dysplasia. The authors discuss the pros and cons of medications used in the treatment of UC.

Navaneethan, Udayakumar; Shen, Bo



Immune cascades in human intervertebral disc: the pros and cons  

PubMed Central

The unique structural hallmark of the intervertebral disc has made its central composition, the nucleus pulposus (NP), excluded from the immunologic tolerance. Consequently, the intervertebral disc is identified as an immune-privileged organ. Traditionally, local detrimental immune activities caused by NP at the lesion sites of the disc are noted as a significant factor contributing to disc degeneration. However, given the beneficial activities of immune cells in other immune-privileged sites on basis of current evidence, the degenerate disc might need the assistance of a subpopulation of immune cells to restore its structure and lessen inflammation. In addition, the beneficial impact of immune cells can be seen in the absorption of the herniated NP, which is an important factor causes the mechanical compression of nerve roots. Consequently, a modulated immune network in degenerate disc is essential for the restoration of this immune-privileged organ. Until now, the understandings of immune response in disc degeneration still rest on the harmful aspect. Further studies are needed to explore its beneficial influence. Accordingly, there are no absolutely the pros and cons in terms of immune reactions caused by NP.

Sun, Zhen; Zhang, Ming; Zhao, Xu-Hong; Liu, Zhi-Heng; Gao, Yang; Samartzis, Dino; Wang, Hai-Qiang; Luo, Zhuo-Jing



Soltando las Amarras - Algunas consideraciones sobre la cancelación de la deuda con el FMI  

Microsoft Academic Search

Este trabajo tiene por objeto analizar dentro de los resultados y proyecciones de la deuda pública, el sentido, impacto y efectos de la decisión gubernamental de cancelar la deuda pública nacional contraída con el FMI. En tal propósito se analizan los motivos que condujeron a la decisión de desendeudarse con el FMI, examinándo las propuestas alternativas a aquella solución, barajadas

Agustin Torres


Detección de anticuerpos antineuronas en pacientes con enfermedades del sistema nervioso: estudio preliminar  

Microsoft Academic Search

RESUMEN Con el objetivo de profundizar en la patogenia de enfermedades que involucren al sistema nervioso central, un colectivo de los laboratorios se dio a la tarea de detectar autoanticuerpos antineuronas en pacientes con estas enfermedades mediante la técnica de inmunofluorescencia indirecta. Se analizaron 31 sueros de pacientes y 72 controles, se obtuvo como resultado una sensibilida d de 77

Raisa Jofra Hernández; Arturo Muster; Roberto Alegre Mendez


ConSearch: An Electronic Document Research and Retrieval Utility for Windows from Management Information Technologies.  

ERIC Educational Resources Information Center

Reviews ConSearch 3.0, a product that provides flexible searching of electronic files, allowing the location of related meanings as well as exact matches. ConSearch 3.0 differs from other file retrieval approaches by relating words in search phrases of questions to the "meaning" of the words, which are stored in a "conceptual database," or lexicon…

Combs, Joseph, Jr.



Alternative Cultural Heterotopia and the Liminoid Body: Beyond Turner at ConFest  

Microsoft Academic Search

This article takes issue with Victor Turner's influential, yet essentialist, category of the limen. While acknowledging Turner's continuing significance in the analysis of public events, I draw upon detailed ethnography of one of Australia's contemporary pilgrimage centres, the alternative lifestyle event ConFest, to reconfigure his project. Although ConFest may prove to be an exemplary field of liminality, as a decidedly

Graham St John



Gestational surrogacy: could be a way to be a way to reproduction? Pros and cons.  


The aim of this article was to address pros and cons of gestational surrogacy, the social and psychological issues involved in surrogate motherhood triads. Pros and cons of surrogacy, the possible insurgence of a hematologic disease in the fetus, hemolytic disease of the newborn, naturally acquired microchimerism in surrogacy cases, ethical, medical, psychologic, legal and religious issues of a problem are discussed. PMID:21778533

Clementina, Peris



Effect of Sup 60 Co gamma Rays on Con A and LPS Induced Lymphocytes.  

National Technical Information Service (NTIS)

The effect of /sup 60/Co gamma -rays on lymphocytes induced by Con A and LPS and the relationship between these two groups of cells were investigated by means of /sup 3/H-TdR incorporation. The study showed that in vitro, Con A cells were able to promote ...

Su L. Liu K. Ma X



CON1D: a computer program for calculating spherically symmetric droplet combustion  

Microsoft Academic Search

This report documents CON1D, a computer program which solves the balance equations describing the spherically symmetric vaporization or combustion of a liquid fuel droplet. CON1D is intended to complement the existing theory of droplet combustion by obtaining solutions in cases which are analytically intractable. For example, calculations are described which clearly demonstrate the effects of gas phase unsteadiness on droplet

R. D. Janssen; P. J. ORourke



A National Look at Postmodernism's Pros and Cons in Educational Leadership  

ERIC Educational Resources Information Center

The purpose of this article is to take a look at the pros and cons of postmodernism. It is imperative for administrators to closely examine educational theories and practices prior to instituting changes. The ability to read and digest challenging material keeps one informed and prepared to lead effectively. This paper will list the pros and cons

Townsell, Rhodena



La gestión de las relaciones con clientes y la empresa de alta rentabilidad de Galicia  

Microsoft Academic Search

RESUMEN La gestión de las relaciones con los clientes es un factor diferencial de las empresas de alta rentabilidad (AR), organizaciones que poseen un elevado rendimiento económico. El presente trabajo propone profundizar en la gestión de clientes como fuente de ventaja competitiva, aplicando la perspectiva de los recursos y capacidades. Con esta finalidad, ofrecemos los resultados obtenidos tras la realización

Pablo Cabanelas Lorenzo; Anxo Moreira



Day\\/Night and Circadian Rhythm Control of Con Gene Expression in Neurospora  

Microsoft Academic Search

In the filamentous fungus Neurospora crassa, several events in the process of conidiation are influenced by light. Two genes, con-6 and con-10, which were previously shown to be transcriptionally activated during conidiation and by exposure to light, were found to be unexpressed in mycelium maintained in constant darkness or in constant light. However, when mycelium was shifted from darkness to

Frank-Roman Lauter; Charles Yanofsky



Determination of composition in stoichiometric Co-N ultrathin films by nitrogen plasma sputtering  

SciTech Connect

This work utilizes low-energy sputtering to incorporate the generated nitrogen plasma into an epitaxial 1.4 nm Co film on the surface of a ZnO(002) substrate. In this method, ultrathin Co-N amorphous films were formed. Interestingly, Co is key to the formation of Co-N films. Without the deposition of Co on the ZnO(002), nitride films cannot be formed. Observations of the surface composition of the Co-N films after the firing of a N{sup +} ion beam onto it demonstrated that the surface concentration of Co reduced at the same rate as the reduction in the concentration of N upon successive sputtering. Theoretical calculations based on the Auger peak-to-peak amplitudes established that the composition of the amorphous Co-N thin films may be Co{sub 3}N{sub 2}.

Su, C. W.; Huang, M. S.; Chang, Y. C.; Tsai, T. H. [Department of Applied Physics, National Chiayi University, 300 Syuefu Rd., Chiayi 60004, Taiwan (China); Lee, Y. H.; Lee, J. C. [Department of Physics, National Cheng Kung University, 1 University Rd., Tainan 70101, Taiwan (China)



The Environmental Impact of Supplying Power to the Con Edison Service Territory: 1975-1990.  

National Technical Information Service (NTIS)

This report describes present and anticipated environmental consequences of meeting electricity demand in the Con Edison service territory--New York City and most of Westchester County. Important issues include nuclear power, air pollution, water and aqua...

A. K. Freedman J. C. Cohen



Il trattamento di una grave neuropatia diabetica con insulina somministrata per via endorachidea  

Microsoft Academic Search

Riassunto Viene descritto un caso di grave poliradicoloneurite diabetica che non aveva tratto alcun miglioramento da un lungo trattamento con vitamina B1 e B12 ad alti dosaggi. Esso giunse a guarigione somministrando insulina direttamente nello speco vertebrale.

Sergio Marigo; Enrico Ferrero



All Frames Are Not Equal: Framing and Con?ict Displacement  

Microsoft Academic Search

Abstract Issue framing afiects individual opinions, mass sentiment, and policy. While most frames reinforce the status quo distribution of opinion, occasionally frames redraw the line of debate. These \\\\con?ict- displacing\\

Suzanna De Boef; Frank R. Baumgartner; Amber E. Boydstun; Frank E. Dardis; Fuyuan Sheny


Quimioterapia de alta dosis prolonga en forma significativa la supervivencia en pacientes con leucemia mieloide aguda

Los resultados preliminares de un estudio clínico grande con asignación al azar de pacientes de 16 a 60 años de edad con leucemia mieloide aguda (LMA), un cáncer de la sangre y de la médula ósea, que no había sido tratada anteriormente, muestran que los pacientes que recibieron una alta dosis de daunorrubicina, un fármaco de quimioterapia disponible comercialmente, durante la terapia inicial vivieron más que los pacientes que recibieron una dosis normal del mismo fármaco.


Análisis comparativo de 3 regímenes de tratamiento en niños con linfoma de Burkitt  

Microsoft Academic Search

Resumen  De enero de 1980 a junio de 1996 se trataron en nuestra institución un total de 86 pacientes con linfoma de Burkitt. El presente\\u000a estudio es una revisión retrospectiva en el que se comparan las complicaciones y los resultados de sobrevida utilizando 3\\u000a esquemas de tratamiento distintos.\\u000a \\u000a Se trataron 46 pacientes en el régimen 1, 26 con el régimen 2,

Rocío Cárdenas Cardós; Roberto Rivera Luna; Roxana Martínez Agreda; Carlos Calderón Elvir; Amparo Plata García



Lupus eritematoso sistemico: un caso di difficile diagnosi differenziale con forme infettive  

Microsoft Academic Search

purpurica, diffuse a tutto il corpo, compresi palmo delle mani e pianta dei piedi. È presente linfoadenopa- tia laterocervicale bilaterale, con linfoghiandole non dolenti, mobili, di 1-2 cm di diametro. Alla palpa- zione dell'addome si evidenzia epa- tosplenomegalia marcata con en- trambi gli organi debordanti tre dita dall'arcata costale. Gli esami ematici eseguiti all'in- gresso (Tab. I) mostrano aumento della




FReCon: a fluid remote controller for a FReely connected world in a ubiquitous environment  

Microsoft Academic Search

In this paper, we propose a Fluid Remote Controller, a general-purpose remote controller based on the ubiquitous computing view. FReCon offers remote control features over a wide range of appliances located within a room, with a unique controller implemented on portable devices like PDAs, handheld PCs, mobile phones, etc. More than the controller itself, FReCon means the whole FReely Connected

Alexandre Sanguinetti; Hirohide Haga; Aya Funakoshi; Atsushi Yoshida; Chiho Matsumoto



THE BATTLE OF THE BANDS ConFest Musics and the Politics of Authenticity  

Microsoft Academic Search

he Australian alternative lifestyle event ConFest (Conference\\/Festival) harbours a dynamic 'underground' music culture. This article investigates the role performed by musics in efforts to establish and maintain 'sanctified' space, and a concomitant sense of community, at Australia's principal alternative cultural pilgrimage destination. The performance, aesthetics and sociality of musics are pivotal in struggles over the definition and purpose of ConFest.




Microsoft Academic Search

La partecipazione di ARPA-SIM al progetto Interreg SEDEMED ha riguardato, per la parte meteorologica, lo studio dei fenomeni siccitosi in Emilia-Romagna attraverso l'indice SPI (Standardized Precipitation Index) e la sua correlazione con la circolazione atmosferica a larga scala e con pattern di variabilità atmosferica, quali la NAO (North Atlantic Oscillation). In ambito agrometeorologico è stata invece studiata la siccità agricola,



SciTech Connect

The purpose of this document is to release, into the Hanford Document Control System, FA1/0991, Sludge Particle Separation Efficiencies for the Rectangular SCS-CON-230 Container, by M. Epstein and M. G. Plys, Fauske & Associates, LLC, June 2009. The Sludge Treatment Project (STP) will retrieve sludge from the 105-K West Integrated Water Treatment System (IWTS) Settler Tanks and transfer it to container SCS-CON-230 using the Settler Tank Retrieval System (STRS). The sludge will enter the container through two distributors. The container will have a filtration system that is designed to minimize the overflow of sludge fines from the container to the basin. FAI/09-91 was performed to quantify the effect of the STRS on sludge distribution inside of and overflow out of SCS-CON-230. Selected results of the analysis and a system description are discussed. The principal result of the analysis is that the STRS filtration system reduces the overflow of sludge from SCS-CON-230 to the basin by roughly a factor of 10. Some turbidity can be expected in the center bay where the container is located. The exact amount of overflow and subsequent turbidity is dependent on the density of the sludge (which will vary with location in the Settler Tanks) and the thermal gradient between the SCS-CON-230 and the basin. Attachment A presents the full analytical results. These results are applicable specifically to SCS-CON-230 and the STRS filtration system's expected operating duty cycles.




Evaluation of the ACT*DE*CON{sup SM} process for treating gunite tank sludge  

SciTech Connect

A test was conducted to evaluate this process for selectively removing actinides from Gunite tank sludge. Mixed waste sludge from Gunite tank W-6 was subjected to the ACT*DE*CON selective leaching process. (Nearly all the TRU content was attributed to Pu.) The sludge sample was first washed with 0.01M NaOH to remove excess sodium and nitrate in the interstitial liquid supernatant. The washed wet solids were treated with the ACT*DE*CON solvent (aqueous carbonate solution containing a chelating agent and an oxidant), using a ratio of 20 ml solvent per gram wet solids. Sludge and solvent were separated by centrifugation, and the ACT*DE*CON treatment was repeated twice. Analyses showed that 71% of the solids in the sludge were dissolved while 80% of the TRU-waste components dissolved. Low separation of the TRU-waste components from other components of the sludge mixture is indicated. Almost all the U and Ca were removed from the sludge. For sludges where most of the TRU content is Pu, the ACT*DE*CON process as tested is not effective in rendering the sludge a non-TRU waste. It is recommended that ACT*DE*CON be optimized for this specific application and that other processes using different chelating and oxidizing agents be tested. Also, the ACT*DE*CON process should be tested on TRU mixed waste in which most of the TRU elements are not Pu.

Spencer, B.B.; Chase, C.W.; Egan, B.Z.



Pros and cons: prospective predictors of marijuana use on a college campus.  


Marijuana use on college campuses is prevalent and associated with high rates of abuse and dependence. The Marijuana Decisional Balance (MDB) scales measure perceived pros and cons toward marijuana use. Evidence supports reliability and concurrent validity of these scales, but the predictive validity has not yet been assessed. The current study evaluated the prospective predictive validity of pros and cons scales for marijuana use, as well as explored predictive validity for marijuana problem indicators. Secondary analyses included test-retest reliability and internal consistency, to provide additional evidence of psychometric properties. A total of 149 college students (57% recent marijuana users, 77% lifetime users) participated in a baseline survey, then completed a second survey one month later. All provided data on marijuana pros and cons, as well as use status in the past month. Users at each time point reported on use frequency, problems, and disorder symptoms. In the month between assessments, 55% of the students used marijuana. Both pros and cons subscales prospectively predicted use status in the subsequent month, but not use frequency. Pros prospectively predicted marijuana problems and dependence symptoms at follow-up, and remained a significant predictor of later dependence symptoms even after controlling for baseline dependence symptoms. In contrast, pros only marginally predicted abuse. Cons did not predict problems, abuse, or dependence symptoms. Pros and cons showed strong test-retest reliability (rs = 0.80-0.85) and internal consistency (alphas = 0.92-0.95). In a college sample, pros and cons of marijuana use demonstrated stability over one month, and prospectively predicted use. Pros may also have utility in predicting problems and dependence potential on college campuses. PMID:22985053

Elliott, Jennifer C; Carey, Kate B



Influence of in vitro irradiation upon LIF production by ConA stimulated mononuclear cells  

SciTech Connect

Leukocyte migration inhibitory factor (LIF) activity of culture supernatants of in vitro irradiated Concanavalin A (ConA) stimulated lymphocytes was tested by measuring granulocyte migration from clotted plasma droplets placed in flat bottom microplates. The specificity of inhibition was assured by pretreating the assay supernatants with anti-LIF antibodies which abrogated granulocyte migration inhibition but did not impair guinea pig Peritoneal Exudate Cells (PEC) migration inhibition. In vitro irradiation (150-1200 rad) of MNC cultures either before or after ConA stimulation did not impair lymphokine production and sometimes significantly improved the supernatants' LIF activity as compared with that of unirradiated cultures. The existence of radiosensitive suppressor cells regulating LIF production by ConA stimulated mononuclear cells is suggested.

Sandru, G.; Veraguth, P.



Influence of in vitro irradiation upon LIF production by ConA stimulated mononuclear cells  

SciTech Connect

Leukocyte migration inhibitory factor (LIF) activity of culture supernatants of in vitro irradiated Concanavalin A (ConA) stimulated lymphocytes was tested by measuring granulocyte migration from clotted plasma droplets placed in flat bottom microplates. The specificity of inhibition was assured by pretreating the assay supernatants with anti-LIF antibodies which abrogated granulocyte migration inhibition but did not impair guinea pig Peritoneal Exudate Cells (PEC) migration inhibition. In vitro irradiation (150-1200 rads) of MNC cultures either before or after ConA stimulation did not impair lymphokine production and sometimes significantly improved the supernatants' LIF activity as compared with that of unirradiated cultures. The existence of radiosensitive suppressor cells regulating LIF production by ConA stimulated mononuclear cells is suggested.

Sandru, G.; Veraguth, P.



Distribución espacial de cúmulos y asociaciones estelares con diferentes edades en la Nube Mayor de Magallanes  

NASA Astrophysics Data System (ADS)

Sobre la base de observaciones realizadas en Cerro Tololo y el Casleo, se presenta un catálogo con fotometría UBV integrada de 504 cúmulos y 120 asociaciones estelares en la Nube Mayor de Magallanes. Se determinan edades en términos de los tipos SWB y se identifican 38 cúmulos tipo VII, muchos de los cuales pueden ser cúmulos globulares clásicos. El tamaño de las distribuciones espaciales crece uniformemente con la edad (tipo SWB), en tanto que existe una diferencia en el cociente axial entre los grupos más jóvenes y más viejos que 30 millones de años, lo que implica una orientación aproximadamente de frente para los primeros y una posición inclinada ~ 45o para el segundo grupo. Las asimetrías en las distribuciones espaciales, juntamente con la falta de coincidencia de los centroides de los diferentes grupos de edad, sugiere que el disco de la Nube Mayor de Magallanes fue severamente perturbado en el pasado.

Bica, E.; Clariá, J. J.; Dottori, H.; Santos, J. F. C.; Piatti, A. E.


Null alleles for salivary Concanavalin A-binding (Con A) and Po proteins at PRB2 and PRB4 loci  

SciTech Connect

Six closely linked PRP (proline-rich protein) genes code for many salivary PRPs which show frequent null variants especially. The Con polymorphism includes the different sized Con 1 and Con 2 proteins and the null Con 0 form. N-terminal amino acid sequences (60 aa) were determined on Con 1 and Con 2 proteins. From comparison of the protein sequences with those deduced from published PRP DNA sequences, Con proteins are probably encoded within exon 3 of the PRB2 gene. Both PRB2 alleles were then cloned from an individual with the Con1/Con 2 phenotype and one PRB2 allele from the individual with the Con 0 phenotype. From DNA sequence analysis, Con 1 is probably a 124 aa protein that is derived by proteolytic processing from a larger precursor, and there are two signals (NKS) for asparagine-linked carbohydrate attachment. However, from the n-terminal protein sequence, the first site is not used. A single nucleotide substitution in the Con 0 allele causes a coding change mutation [TCT (Ser){yields}CCT(Pro)] that abolishes the postulated single functional carbohydrate attachment site (NKS{yields}NKP) and explains the absence of Con 1 protein staining on the Western blot in Con 0 homozygotes. The n-terminal sequence of the Con 2 protein was not encoded in either PRB2 allele from the individual with the Con 1/Con 2 phenotype and must be encoded by another PRB locus. The non-glycosylated 70 aa Po protein which shows Po+ and Po- phenotypes was known to be encoded by exon 3 of the PRB4 gene. The DNA sequence from exon 3 of PRB4 from an individual with the Po- phenotype was compared to that previously published from a Po+ individual. A nucleotide substitution was found at the {open_quotes}invariant{close_quotes} +1 position [GT{yields}CT] of the exon 3 5{prime}-splice site. This mutation adequately accounts for the Po- phenotype.

Azen, E.A.; Amberger, E. [Univ. of Wisconsin, Madison, WI (United States)



Soluciones analiticas AL problema de jets con velocidad de eyeccion variable EN EL tiempo.  

NASA Astrophysics Data System (ADS)

Se presenta un nuevo metodo que permite resolver de manera exacta y analitica las ecuaciones que describen un jet hipersonico con velocidad de eyeccion variable en el tiempo. El metodo se basa en consideraciones sencillas de conservacion de momento para las superficies de trabajo que se forman en el interior del jet. Como ejemplo, se presentan soluciones para jets con variacion sinusoidal en la velocidad de eyeccion, y tambien para el caso de un incremento lineal en el tiempo. Estas soluciones analiticas tienen una clara aplicacion en la interpretacion de las observaciones de jets asociados a objetos Herbig-Haro.

Canto, J.; Raga, A. C.; D'Alessio, P.



Salud con Sabor Latino: a culturally sensitive obesity prevention curriculum in an underserved Latino community  

Microsoft Academic Search

Salud con Sabor Latino is a culturally sensitive obesity prevention curriculum that incorporates the traditions and values of the Latino community and family. The 4-week curriculum meets twice a week and includes an education and cooking component. Key components of the curriculum are portion size, reading food labels, taking small steps, eating a variety of foods, and the importance of

Christina Araiza; Maria Valenzuela; Bonnie Gance-Cleveland



The Con Edison Emergency Child Care Plan for Management Employees: Summary Plan Description.  

ERIC Educational Resources Information Center

This summary plan description offers guidelines for participation in a pilot program that provides short-term emergency care for children of Con Edison managers who are under 13 years old. The plan offers professional, in-home child care that can be used when usual arrangements have collapsed. The summary plan description addresses the following…

Consolidated Edison Co., Brooklyn, NY.


ConText: An algorithm for determining negation, experiencer, and temporal status from clinical reports  

Microsoft Academic Search

In this paper we describe an algorithm called ConText for determining whether clinical conditions mentioned in clinical reports are negated, hypothetical, historical, or experienced by someone other than the patient. The algorithm infers the status of a condition with regard to these properties from simple lexical clues occurring in the context of the condition. The discussion and evaluation of the

Henk Harkema; John N. Dowling; Tyler Thornblade; Wendy Webber Chapman



The pros and cons of computing the h-index using Google Scholar  

Microsoft Academic Search

Purpose – A previous paper by the present author described the pros and cons of using the three largest cited reference enhanced multidisciplinary databases and discussed and illustrated in general how the theoretically sound idea of the h-index may become distorted depending on the software and the content of the database(s) used, and the searchers' skill and knowledge of the

Pe´ter Jacso´



Sludge Particle Separation Efficiencies During Settler Tank Retrieval Into SCS-CON-230.  

National Technical Information Service (NTIS)

The purpose of this document is to release, into the Hanford Document Control System, FA1/0991, Sludge Particle Separation Efficiencies for the Rectangular SCS-CON-230 Container, by M. Epstein and M. G. Plys, Fauske & Associates, LLC, June 2009. The Sludg...

J. I. Dearing M. Epstein M. G. Plys




Microsoft Academic Search

El chile jalapeño provoca un alto nivel de irritación a diferentes niveles del tracto estomacal en comparación con el chile habanero. A pesar de que el chile habanero presenta una mayor capacidad pungente, no es irritante. A la fecha se desconoce la naturaleza de los compuestos responsables de este efecto. En el presente trabajo se reporta el análisis preliminar de

Salvador Horacio; Guzmán Maldonado; Irineo Torres Pacheco; Mario González Chavira; María Alejandra; Mora Avilés; Guadalupe Herrera Hernández; David Hernández López


Immunostimulatory activity of ConBr: a focus on splenocyte proliferation and proliferative cytokine secretion.  


Lectins constitute a class of glycoproteins, which are capable of selectively and reversibly binding to carbohydrates, distinguishing small structural differences in complex oligosaccharides. Studies have shown that the binding of lectins to cell-surface carbohydrates can lead to various effects such as cellular proliferation, histamine release and cytokine production. Canavalia brasiliensis lectin (ConBr) is a (D-mannose) D-glucose lectin. In this study, murine splenocytes were cultured to determine the effect of ConBr on cell proliferation, nitric oxide (NO) release and cytokine secretion. In addition, cellular viability assays were performed to evaluate any mitogenic activity induced by this lectin. ConBr significantly increased cell proliferation with minimal cell damage. This lectin was able to induce an increased production of cytokines such as IL-2, IL-6 and IFN-? and a decreased production of IL- 10. The release of NO was also observed. The results of this study indicate that ConBr could potentially be used as an immunomodulator. PMID:22009293

de Oliveira Silva, Flávio; das Neves Santos, Priscila; de Melo, Cristiane Moutinho Lagos; Teixeira, Edson Holanda; de Sousa Cavada, Benildo; Arruda, Francisco Vassiliepe Sousa; Cajazeiras, João Batista; Almeida, Alysson Chaves; Pereira, Valéria Alves Rêgo; Porto, Ana Lúcia Figueiredo



Stress state in the Cuu Long and Nam Con Son basins, offshore Vietnam  

Microsoft Academic Search

The results presented in this paper are the first published estimates of the complete stress tensor in the Cuu Long and Nam Con Son basins, offshore Vietnam. We analysed in situ stress and pore pressure fields in the sedimentary formations using data from petroleum exploration and production wells to evaluate the stress state in these basins. The data were obtained

Nguyen Thi Thanh Binh; Tomochika Tokunaga; Neil R. Goulty; Hoang Phuoc Son; Mai Van Binh



Structure, stratigraphy and petroleum geology of the south east Nam Con Son Basin, offshore Vietnam  

Microsoft Academic Search

Recent exploration of the south east Nam Con Son Basin, offshore Vietnam, by BP in alliance with Statoil has involved acquisition of new seismic and well data. These new data have allowed re-evaluation of the tectono-stratigraphic development and petroleum geology, and have provided additional constraints on the regional tectonic evolution. The offshore Vietnamese basins have evolved in response to the

A. J. Fraser; S. J. Matthews; S. Lowe; S. P. Todd; Simon; F. J. P. Peel



The pros and cons of Microsoft Academic Search from a bibliometric perspective  

Microsoft Academic Search

Purpose – This paper aims to look at the pros and cons of Microsoft Academic Search (MAS) from a bibliometric perspective. Design\\/methodology\\/approach – This paper describes the major content and software features of MAS, and its shortcomings. Findings – The paper recommends some further enhancements, and the use of care and caution when interpreting the metrics produced by cited reference

Péter Jacsó



Are You Ready to Go Digital?: The Pros and Cons of Electronic Portfolio Development  

ERIC Educational Resources Information Center

|There is an increasing need for educators to have professional portfolios, which are considered to be authentic tools for evaluating the knowledge, skill, beliefs and attitudes of prospective educators. Electronic portfolios are gaining in popularity and their relative pros and cons are examined.|

Heath, Marilyn



Quattordici Punti di accordo con i rapporti ufficiali governativi sulla distruzione del World Trade Center  

Microsoft Academic Search

I rapporti di FEMA e NIST contengono la versione ufficiale sulla distruzione del World Trade Center, avvenuta l'11 settembre 2001. In questa lettera vogliamo porre le basi per una discussione costruttiva e chiarificatrice, focalizzandoci sui punti di comune accordo con FEMA e NIST, e refutando nel contempo diverse credenze errate sui crolli del WTC. L'undici settembre 2001 le Torri Gemelle

Steven E. Jones; Frank M. Legge; Kevin R. Ryan; Anthony F. Szamboti; James R. Gourley


Evaluación del estado de salud con la Encuesta SF36: resultados preliminares en México  

Microsoft Academic Search

Objective. To establish a multidimensional profile of the health status in a population of southeastern Mexico and analyze the psychometric properties of a translation of the SF-36 survey authorized by the International Quality of Life Assessment Project. Material and methods. The SF-36 was administered to 257 volunteers of a clinic and a con- trol group in a governmental institution. The

Miguel A. Zúniga; Genny T. Carrillo-Jiménez; Peter J. Fos; Barbara Gandek; Manuel R. Medina-Moreno



Comparison of radiosensitivity of human lymphocytes stimulated with PHA Con A and PWM.  

National Technical Information Service (NTIS)

The transformation, DNA strand breaks and its repair ability in human peripheral blood lymphocytes stimulated with PHA, Con A and PWM were respectively assessed following exposure to (sup 60)Co gamma rays by (sup 3)H-thymidine uptake and hydroxylapatite c...

Y. Geng L. Su



Índice de Comportamiento Objetivo. Una medida para valorar la respuesta al tratamiento de pacientes con trastornos de personalidad graves  

Microsoft Academic Search

Una medida que capta la frecuencia e intensidad de comportamientos disfuncionales experimentados, así como el uso de los servicios de salud mental, se desarrollaron y probaron como parte de un ensayo de tratamiento controlado de pacientes con trastorno de personalidad borderline. El índice de comportamiento objetivo (ICO) se realizó con 136 individuos diagnosti- cados de trastorno de personalidad borderline antes

Heather Munroe-Blum; Lynn McClearly


76 FR 54533 - Pipeline Safety: Issuance of Draft Decision on GexCon US, Inc. Petition for Approval of Flame...  

Federal Register 2010, 2011, 2012, 2013

...Draft Decision on GexCon US, Inc. Petition for Approval of Flame Acceleration Simulator AGENCY: Pipeline and Hazardous Materials...Draft Decision on GexCon US, Inc.'s petition for approval of Flame Acceleration Simulator (FLACS). The Draft Decision is...



Railroad Accident Report - Rear End Collision of Two ConRail Freight Trains, Stemmers Run, Baltimore, Maryland, June 12, 1977.  

National Technical Information Service (NTIS)

About 11:03 p.m., on June 12, 1977, ConRail freight train WA-4 collided with the rear of ConRail freight train WA-6. A fire began in the lead locomotive unit of train WA-4 and in the caboose of train WA-6. Damage was about $300.000. Two crewmembers on eac...




Microsoft Academic Search

Resumen Objetivos: Explorar la hipótesis de que una personalidad de relaciones y de comunicación res- tringida, pérdidas personales penosas aunque no extraordinarias pero con incapacidad de afrontar positivamente las mismas, y una desmotivación plural persistente que se ensambla con un auto bloqueo perceptivo, constituyen una secuencia y un perfil peculiar de las personas que concluyen en Alzheimer, a dife- rencia



Probing of Brain States in Real-Time: Introducing the ConSole Environment  

PubMed Central

Recent years have seen huge advancements in the methods available and used in neuroscience employing EEG or MEG. However, the standard approach is to average a large number of trials for experimentally defined conditions in order to reduce intertrial-variability, i.e., treating it as a source of “noise.” Yet it is now more and more accepted that trial-to-trial fluctuations bear functional significance, reflecting fluctuations of “brain states” that predispose perception and action. Such effects are often revealed in a pre-stimulus period, when comparing response variability to an invariant stimulus. However such offline analyses are disadvantageous as they are correlational by drawing conclusions in a post hoc-manner and stimulus presentation is random with respect to the feature of interest. A more direct test is to trigger stimulus presentation when the relevant feature is present. The current paper introduces Constance System for Online EEG (ConSole), a software package capable of analyzing ongoing EEG/MEG in real-time and presenting auditory and visual stimuli via internal routines. Stimulation via external devices (e.g., transcranial magnetic stimulation) or third-party software (e.g., PsyScope X) is possible by sending TTL-triggers. With ConSole it is thus possible to target the stimulation at specific brain states. In contrast to many available applications, ConSole is open-source. Its modular design enhances the power of the software as it can be easily adapted to new challenges and writing new experiments is an easy task. ConSole is already pre-equipped with modules performing standard signal processing steps. The software is also independent from the EEG/MEG system, as long as a driver can be written (currently two EEG systems are supported). Besides a general introduction, we present benchmark data regarding performance and validity of the calculations used, as well as three example applications of ConSole in different settings. ConSole can be downloaded at:

Hartmann, Thomas; Schulz, Hannah; Weisz, Nathan



ConBr, a lectin from Canavalia brasiliensis seeds, protects against quinolinic acid-induced seizures in mice.  


Lectins are proteins capable of reversible binding to carbohydrates or glycoconjugates. In the central nervous system of mammals, lectins with affinity for mannose/glucose or galactose can modulate cellular communication. ConBr, a lectin isolated from the seeds of Canavalia brasiliensis, previously showed antidepressant effect in the forced swimming test in mice, with involvement of the monoaminergic system. In this study, we investigated the neuroprotective effects of ConBr against quinolinic acid (QA), a well-known NMDA agonist that produces severe neurotoxicity when administered in vivo. ConBr (10 ?g/site) administered via intracerebroventricular (i.c.v.) showed a neuroprotective activity against seizures induced by QA (36.8 nmol/site; i.c.v.) when administered 15 min prior to QA, with a percentage of protection around 50%. ConBr was also able to significantly decrease the severity of the seizures but without changes in the latency of the first convulsion or the duration of the seizures. This effect was dependent on the structural integrity of the ConBr protein and its binding capacity to oligosaccharides residues. ConA, a lectin with high similarity to ConBr, did not reverse the QA-induced seizures. Moreover, ConBr was able to protect against hippocampal cell death caused by QA, which was measured by propidium iodide incorporation. QA caused activation of JNK2 and improved the phosphorylation of Ser831 and 845 on the AMPA receptor GluR1 subunit, and both of these effects were counteracted by ConBr. Our data suggest that the lectin ConBr may exert a modulatory action on NMDA receptors, which inhibits its activity in response to QA. PMID:21948344

Russi, Michael A; Vandresen-Filho, Samuel; Rieger, Débora K; Costa, Ana Paula; Lopes, Mark W; Cunha, Rodrigo M S; Teixeira, Edson H; Nascimento, Kyria S; Cavada, Benildo S; Tasca, Carla I; Leal, Rodrigo B



Anticipated Stigma and Stigma Management Among Those to be Labeled “Ex-con  

Microsoft Academic Search

Male prisoners (n = 450) estimated public reaction to the label “ex-con” and endorsed likely stigma management strategies. Although most anticipate significant rejection, they prefer preventative telling to withdrawal and secrecy as adjustments. OLS regression finds factors promoting exclusion (devaluation\\/discrimination beliefs and reduced job opportunities) related to withdrawal and secrecy, whereas factors favoring inclusion (“wise” family and friends and plans to attend

Terri A. Winnick; Mark Bodkin



Effect of ConA-receptor interaction on the structure of cell membrane  

Microsoft Academic Search

Recently, the effect of ligand receptor interaction on the membrane structure of liposomes has been studied extensively. However, little is known about how it exists on biological membranes. In this paper, the effect of Concanavalin A (ConA) receptor interaction on the structure of cell membranes was studied by Circular Dichroism (CD) and 31P Nuclear Magnetic Resonance (NMR).CD results of both

Jianwu Dai; Qun Dong; Yaxian Su; Kechun Lin



Mound-ACT*DE*CON{sup SM} feasibility study. Phase 2: Final report  

SciTech Connect

A portion of the abandoned Miami-Erie Canal paralleling the Greater Miami River receives the runoff and storm-water discharge from Mound Laboratory. In 1969, a low-level plutonium leak contaminated sediment as far away as 1.5 mi from the Mound site along the old canal system. An estimated one million cubic feet of sediment requires remediation. The technology being evaluated for the remediation of the low-level plutonium-238 contamination of the sediment involves two processes: washing the sediments with ACT*DE*CON{sup SM} solution to dissolve the contaminant, followed by extraction of the solution and processing with the MAG*SEP{sup SM} process to concentrate the contaminant and allow reuse of the ACT*DE*CON{sup SM} solution. The processes are being optimized for pilot-scale and field demonstration. Phase 2 of the project primarily involved identification at the laboratory scale of the optimal ACT*DE*CON{sup SM} formulation, identification of the ion-exchanger and MAG*SEP{sup SM} particles, verification of the plutonium mobility in the treated soil, and evaluation of other process parameters according to a series of tasks.




Con_A-carbone nanotube conjugate with short wave near-infrared laser ablation for tumor therapy  

NASA Astrophysics Data System (ADS)

Using the characteristics of T cell mitogen called lectin protein from the jack-beam Canavalia ensiformis Concanavalin A (Con_A) with dual activities, cytotoxicity and immunomodulation, we have shown it has a therapeutic effect on hepatoma. Injection of Con_A can eradicate the established malign tumor, because Con_A can induce tumor cell autophagic, cell-programmed death, as well as activate the effector T cells. Combined, in this paper, with the absorption exceeding the Carbon NanoTube (CNT) band-gap (?bg=~1/CNT diameter) with an active short wave near-infrared (SWIR) (1.2~1.5 micron wavelengths), which happened to be translucent to the irradiation upon animal skin, similar to that used in hospital fingertip-clamped Pulse Oxymetry. Once the Con_ACNT is guided to hepatoma cells, it is bonded and internalized into the mitochondria (MC) compartment, the cellular energy factory. Con_A has the higher specificity for tumor cells useful for targeting because of the abnormal glycosylation on tumor cells. When CNT hitch hike with Con_A, they can t together like a laser-denotable chemical missile surgically targeting at the tumor cells precisely by Con_A-guidance. We switch on SWIR laser, when the Con_A-CNT conjugated complex has been bonded and internalized to MC of malign cells and already commenced cellular programmed death. Thus, it might appear to casual readers that we have initiated an overkill, chemical drugged autophage followed with physical laser ablation, but what if we can eradicate hepatoma totally if no blue print is left behind inadvertently in case of a partial failure. We conclude that using Con_A-CNT conjugated complex targeting specifically at malign tumor cells is a novel targeted-laser-radiation therapy for tumors in mice.

Lei, Huan-Yao; Peng, Ching-An; Tang, Ming-Jer; Reindhart, Kit; Szu, Harold H.



40 CFR 180.1213 - Coniothyrium minitans strain CON/M/91-08; exemption from the requirement of a tolerance.  

Code of Federal Regulations, 2013 CFR

...false Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...1213 Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...pesticide Coniothyrium minitans strain CON/M/91-08 when used in or on all food...



40 CFR 180.1213 - Coniothyrium minitans strain CON/M/91-08; exemption from the requirement of a tolerance.  

Code of Federal Regulations, 2010 CFR

...2009-07-01 false Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...1213 Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...pesticide Coniothyrium minitans strain CON/M/91-08 when used in or on all...



40 CFR 180.1213 - Coniothyrium minitans strain CON/M/91-08; exemption from the requirement of a tolerance.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...1213 Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...pesticide Coniothyrium minitans strain CON/M/91-08 when used in or on all...




Microsoft Academic Search

Las habilidades sociales son un numeroso y variado conjunto de conductas que se ponen en juego en situaciones de interacción social, es decir, en situaciones en las que hay que relacionarse con otras personas. La Interacción social se refiere a las conductas necesarias para interactuar y relacionarse con los iguales y con los adultos de forma efectiva y mutuamente satisfactoria.

Elizabeth Gómez Núñez; Olga Lidia Núñez Rodriguez; Nemesio Jiménez Cepero; Ángel Luis Gómez Cardoso



Correlación entre la estructura de bandas y las propiedades físicas de óxidos cerámicos de estructura perovskita con metales de transición (I): Propiedades de conducción electrónica  

Microsoft Academic Search

En este artículo se revisa los principales modelos teóricos, que pretenden dar una explicación sobre las propiedades de con- ducción electrónica de óxidos cerámicos con estructura perovskita, que incluyen en la posición B metales de transición del primer período (Fe, Co, Ni, Mn), en conexión con su estructura de bandas y el carácter de sus electrones más externos, así como



Con A induction of IgG secretion from a B-lymphoid tumour cell line, A20.  

PubMed Central

We have examined the effect of concanavalin A (Con A), a conventionally known T-cell mitogen, on the induction of Ig secretion from BALB/c B lymphoid cell lines expressing membrane IgM (X16C8.5, BALENTL 17.7.2 and BCL1) or membrane IgG (A20 and M12.4). A20 tumour cells, but not other tumour cells, responded to Con A by secreting Ig as measured by the reverse plaque-forming cell (PFC) assay. Another typical T-cell mitogen, phytohaemagglutinin (PHA), did not have any effect on the differentiation of A20 tumour cells. The addition of NaN3 abolished the PFC formation, showing that IgG PFC formation of A20 tumour cells was due to the active synthesis of secreted IgG and not due to the shedding of mIgG. The increase in the biosynthesis of secreted IgG from A20 tumour cells by Con A was also observed by polyacrylamide gel electrophoresis. The ability of Con A to induce IgG secretion from A20 tumour cells was abolished by the addition of alpha-methylmannoside, confirming that Con A itself, and not some contaminating material in Con A, induced the maturation of A20 tumour cells. Con A was also shown to induce Ig secretion, but not proliferation, in a subset of normal B cells. Thus, we conclude that Con A does give a differentiation signal to a subset of B cells. Images Figure 2

Kim, K J; Dejoy, S Q



Con A induction of IgG secretion from a B-lymphoid tumour cell line, A20.  


We have examined the effect of concanavalin A (Con A), a conventionally known T-cell mitogen, on the induction of Ig secretion from BALB/c B lymphoid cell lines expressing membrane IgM (X16C8.5, BALENTL 17.7.2 and BCL1) or membrane IgG (A20 and M12.4). A20 tumour cells, but not other tumour cells, responded to Con A by secreting Ig as measured by the reverse plaque-forming cell (PFC) assay. Another typical T-cell mitogen, phytohaemagglutinin (PHA), did not have any effect on the differentiation of A20 tumour cells. The addition of NaN3 abolished the PFC formation, showing that IgG PFC formation of A20 tumour cells was due to the active synthesis of secreted IgG and not due to the shedding of mIgG. The increase in the biosynthesis of secreted IgG from A20 tumour cells by Con A was also observed by polyacrylamide gel electrophoresis. The ability of Con A to induce IgG secretion from A20 tumour cells was abolished by the addition of alpha-methylmannoside, confirming that Con A itself, and not some contaminating material in Con A, induced the maturation of A20 tumour cells. Con A was also shown to induce Ig secretion, but not proliferation, in a subset of normal B cells. Thus, we conclude that Con A does give a differentiation signal to a subset of B cells. PMID:3530982

Kim, K J; Dejoy, S Q



Effect of GonaCon™ vaccine on black-tailed prairie dogs: immune response and health effects.  


Management of prairie dogs in the past has included poisoning, fumigants, barriers, and relocation. Because of the diverse attitudes related to prairie dog management, nonlethal methods that allow the existence of prairie dogs but help minimize damage related to population growth need to be developed. GonaCon™ is an immunocontraceptive vaccine that elicits antibodies to native GnRH; this prevents the secretion of reproductive hormones necessary for sperm and oocyte production. Prairie dogs were vaccinated with 0.1, 0.2, or 0.4 mL of the GonaCon™ emulsion intramuscularly in the upper thigh containing 100, 200, or 400 ?g GnRH conjugate, respectively. Control animals were vaccinated with 0.4 mL saline emulsion in the upper thigh. Blood samples (?1 mL) were taken from the femoral vein once pretreatment and at 1, 2, 3, 4, 6, and 15 months post-vaccination. Age (adult or juvenile) did not affect immune response to GonaCon™. Antibody titers were higher in the 200 and 400 ?L GonaCon™ groups than in the 100 ?L group, and there was no difference between the 200 and 400 ?L GonaCon™ groups. No adverse effects of GonaCon™ were noted on weight or blood chemistry parameters during the study. GonaCon™ will likely contracept prairie dogs for ?1 year in the field using either 200 or 400 ?g conjugate. GonaCon™ could be incorporated into management plans to help maintain prairie dog populations while reducing habitat degradation due to overpopulation. PMID:21055491

Yoder, Christi A; Miller, Lowell A



ConMap: Investigating new computer-based approaches to assessing conceptual knowledge structure in physics  

NASA Astrophysics Data System (ADS)

There is a growing consensus among educational researchers that traditional problem-based assessments are not effective tools for diagnosing a student's knowledge state and for guiding pedagogical intervention, and that new tools grounded in the results of cognitive science research are needed. The ConMap (``Conceptual Mapping'') project, described in this dissertation, proposed and investigated some novel methods for assessing the conceptual knowledge structure of physics students. A set of brief computer-administered tasks for eliciting students' conceptual associations was designed. The basic approach of the tasks was to elicit spontaneous term associations from subjects by presenting them with a prompt term, or problem, or topic area, and having them type a set of response terms. Each response was recorded along with the time spent thinking of and typing it. Several studies were conducted in which data was collected on introductory physics students' performance on the tasks. A detailed statistical description of the data was compiled. Phenomenological characterization of the data (description and statistical summary of observed patterns) provided insight into the way students respond to the tasks, and discovered some notable features to guide modeling efforts. Possible correlations were investigated, some among different aspects of the ConMap data, others between aspects of the data and students' in-course exam scores. Several correlations were found which suggest that the ConMap tasks can successfully reveal information about students' knowledge structuring and level of expertise. Similarity was observed between data from one of the tasks and results from a traditional concept map task. Two rudimentary quantitative models for the temporal aspects of student performance on one of the tasks were constructed, one based on random probability distributions and the other on a detailed deterministic representation of conceptual knowledge structure. Both models were reasonably successful at approximating the statistical behavior of a typical student's data.

Beatty, Ian D.



Nitrogen-detected CAN and CON experiments as alternative experiments for main chain NMR resonance assignments  

PubMed Central

Heteronuclear direct-detection experiments, which utilize the slower relaxation properties of low ? nuclei, such as 13C have recently been proposed for sequence-specific assignment and structural analyses of large, unstructured, and/or paramagnetic proteins. Here we present two novel 15N direct-detection experiments. The CAN experiment sequentially connects amide 15N resonances using 13C? chemical shift matching, and the CON experiment connects the preceding 13C? nuclei. When starting from the same carbon polarization, the intensities of nitrogen signals detected in the CAN or CON experiments would be expected four times lower than those of carbon resonances observed in the corresponding 13C-detecting experiment, NCA-DIPAP or NCO-IPAP (Bermel et al. 2006b; Takeuchi et al. 2008). However, the disadvantage due to the lower ? is counteracted by the slower 15N transverse relaxation during detection, the possibility for more efficient decoupling in both dimensions, and relaxation optimized properties of the pulse sequences. As a result, the median S/N in the 15N observe CAN experiment is 16% higher than in the 13C observe NCA-DIPAP experiment. In addition, significantly higher sensitivity was observed for those residues that are hard to detect in the NCA-DIPAP experiment, such as Gly, Ser and residues with high-field C? resonances. Both CAN and CON experiments are able to detect Pro resonances that would not be observed in conventional proton-detected experiments. In addition, those experiments are free from problems of incomplete deuterium-to-proton back exchange in amide positions of perdeuterated proteins expressed in D2O. Thus, these features and the superior resolution of 15N-detected experiments provide an attractive alternative for main chain assignments. The experiments are demonstrated with the small model protein GB1 at conditions simulating a 150 kDa protein, and the 52 kDa glutathione S-transferase dimer, GST.

Takeuchi, Koh; Heffron, Gregory; Sun, Zhen-Yu J.; Frueh, Dominique P.



Lesbian (in)visibility in Italian Renaissance culture: Diana and other cases of donna con donna.  


Current conceptualizations of sexual identity in the West are not necessarily useful to an historian investigating "lesbianism" in the social history and visual representations of different periods. After an overview of Renaissance documents treating donna con donna relations which examines the potentially positive effects of condemnation and silence, the paper focuses on Diana, the goddess of chastity, who bathed with her nymphs as an exemplar of female bodies preserved for heterosexual, reproductive pleasures. Yet the self-sufficiency and bodily contact sometimes represented in images of this secluded all-female gathering might suggest "deviant" responses from their viewers. PMID:7798609

Simons, P



Cámara CCD Directa con el Telescopio de 2.15 m del CASLEO: algunos diagnósticos  

NASA Astrophysics Data System (ADS)

Se efectuaron algunas pruebas con la cámara CCD (+ Reductor Focal) instalada en el foco Cassegrain del Telescopio de 2.15 m del Complejo Astronómico El Leoncito (CASLEO). Las conclusiones más significativas son: Los tiempos de exposición efectivos difieren de los nominales en una fracción apreciable de segundo. En exposiciones de menos de 3 segundos, la iluminación no es pareja en todo el detector. En consecuencia, se recomiendan los pasos a seguir por los astrónomos tanto durante la observación como en la reducción de sus datos.

Cellone, S. A.


An aggregation of pro and con evidence for medical decision support systems.  


One promising way to increase the classification accuracy of medical decision support systems is to implement heuristic combinations of pattern recognition and artificial intelligence tools. A parallel between "cognition" model and differential diagnostic task is sketched accentuating the aggregation of activating and restraining inputs and corresponding PRO and CON evidence in medicine. On the basis of this paradigm a trainable model of a fuzzy neuron is proposed which resembles some elements from the physician's decision process. An example from aviation medicine is presented which demonstrates the enhanced performance. PMID:8306621

Kuncheva, L



Un estudio financiado por los Institutos Nacionales de la Salud (NIH) muestra reducción en la mortalidad entre hombres con cáncer de próstata en grado intermedio:

Terapia hormonal por corto tiempo administrada en combinación con radioterapia a hombres con cáncer de próstata en estadio inicial aumentó sus posibilidades de vivir más en comparación con tratamiento de radioterapia sola, según un estudio clínico patrocinado por el NCI. Los beneficios del tratamiento combinado se limitaron principalmente a pacientes con enfermedad de riesgo intermedio y no se observaron en hombres con cáncer de próstata de riesgo bajo, indican los investigadores.


Quick fix or long-term cure? Pros and cons of bariatric surgery  

PubMed Central

The past decade has seen an enormous increase in the number of bariatric, or weight loss, operations performed. This trend is likely to continue, mirroring the epidemic of obesity around the world and its rising prevalence among children. Bariatric surgery is considered by many to be the most effective treatment for obesity in terms of maintenance of long-term weight loss and improvement in obesity-related comorbid conditions. Although overly simplified, the primary mechanisms of the surgical interventions currently utilized to treat obesity are the creation of a restrictive or malabsorptive bowel anatomy. Operations based on these mechanisms include the laparoscopic adjustable gastric band and laparoscopic vertical sleeve gastrectomy (considered primarily restrictive operations), the laparoscopic biliopancreatic diversion with or without a duodenal switch (primarily malabsorptive operation), and the laparoscopic Roux-en-Y gastric bypass (considered a combination restrictive and selective malabsorptive procedure). Each operation has pros and cons. Important considerations, for the patient and surgeon alike, in the decision to proceed with bariatric surgery include the technical aspects of the operation, postoperative complications including long-term nutritional problems, magnitude of initial and sustained weight loss desired, and correction of obesity-related comorbidities. Herein, the pros and cons of the contemporary laparoscopic bariatric operations are reviewed and ongoing controversies relating to bariatric surgery are discussed: appropriate patient selection, appropriate operation selection for an individual patient, surgeon selection, and how to measure success after surgery.

Madura, James A.



Preparation of stimulus responsive multiple emulsions by membrane emulsification using con a as biochemical sensor.  


In this work, a novel strategy for the controlled fabrication of biomolecular stimulus responsive water-in-oil-in-water (W/O/W) multiple emulsion using the membrane emulsification process was investigated. The emulsions interface was functionalized with a biomolecule able to function as a receptor for a target compound. The interaction between the biomolecular receptor and target stimulus activated the release of bioactive molecules contained within the structured emulsion. A glucose sensitive emulsion was investigated as a model study case. Concanavalin A (Con A) was used as the biomolecular glucose sensor. Various physicochemical strategies for stimulus responsive materials formulation are available in literature, but the preparation of biomolecule-responsive emulsions has been explored for the first time in this paper. The development of novel drug delivery systems requires advanced and highly precise techniques to obtain their particular properties and targeting requirements. The present study has proven the flexibility and suitability of membrane emulsification for the preparation of stable and functional multiple emulsions containing Con A as interfacial biomolecular receptor able to activate the release of a bioactive molecule as a consequence of interaction with the glucose target molecule. The influence of emulsion interfacial composition and membrane emulsification operating conditions on droplets stability and functional properties have been investigated. The release of the bioactive molecule as a function of glucose stimulus and its concentration has been demonstrated. PMID:21404264

Piacentini, Emma; Drioli, Enrico; Giorno, Lidietta



[AnaConDa as last resort treatment. Case report of a chronic obstructive pulmonary disease].  


Treatment of patients suffering from decompensated chronic pulmonary disease (COPD) not responding to pharmacological therapy is still a major challenge in intensive care medicine. Administration of volatile anaesthetics may be a therapy of last resort in these cases. We report on a 65-year-old woman suffering from exacerbated COPD, who could not be sufficiently ventilated despite comprehensive pharmacological therapy. In order to administer a volatile anaesthetic in the ICU, we employed the "Anaesthetic Conserving Device" (AnaConDa) consisting of a vaporizer chamber embedded in a charcoal filter system. With this device, every standard intensive care ventilator can be used to deliver volatile anaesthetics in a safe and economic manner. The AnaConDa converts the open breathing system of the intensive care ventilator into a de facto half-closed system. The very low pulmonary compliance of the patient increased dramatically after administration of 0.75 vol% halothane for 48 h (27 vs. 150 ml/mbar). Elimination of CO(2) was improved and weaning from controlled ventilation was achieved. After surgical removal of a pulmonary abscess and a total of 78 days of intensive care therapy, the patient was discharged in good health. PMID:17375268

Nickel, E A; Benken, I; Bartels, U; Voelckel, W G; Quintel, M



Field performance of the RespiCon for size-selective sampling of industrial wood processing dust.  


The RespiCon sampler is a multistage virtual impactor that simultaneously collects the ISO/CEN/ACGIH size fractions of inhalable, thoracic, and respirable particulate matter. The field performance of the device for measurement of industrial wood processing dust was evaluated against reference size-selective samplers: the IOM sampler (inhalable dust), the GK 2.69 cyclone (thoracic dust), and the SKC aluminum cyclone (respirable dust). Seventy-one sets of area samples were collected from 10 wood processing plants, with the samplers mounted either in the free-field or on a two-dimensional bluff body. The geometric mean (range) dust levels across all plants measured by the reference samplers were: inhalable, 1.35 mg/ m3 (0.11-11.06); thoracic, 0.31 mg/m3 (0.05-1.38); and respirable, 0.10 mg/m3 (0.02-0.54). In comparing the RespiCon with the reference samplers, there was no significant difference between sampling in the free-field versus bluff-body modes. For inhalable dust, there was no significant difference between the RespiCon and the IOM sampler after applying a correction factor of 1.5 to the extrathoracic data obtained from the RespiCon. Without the correction factor, the RespiCon undersample inhalable dust by an average of 23%. For thoracic dust, the RespiCon was shown to oversample the extrathoracic dust fraction resulting in an overall error of 48%. A simple correction based on the inhalable and thoracic dust levels reported by the RespiCon is proposed. For respirable dust, there was a significant difference between the RespiCon and the SKC cyclone, but the data were equivocal due to imprecision in measurement of the low respirable dust concentrations encountered and the likelihood of bias in the reference sampler. Overall, the RespiCon sampler appears to be a suitable size-selective sampling device for industrial wood processing dust, although adjustments should be made to the inhalable and thoracic dust results. PMID:15788383

Rando, Roy; Poovey, Halet; Mokadam, Dinkar; Brisolara, Joseph; Glindmeyer, Henry



A con-focal setup for micro-XRF experiments using diamond anvil cells  

NASA Astrophysics Data System (ADS)

In this contribution we introduce an experimental setup to perform con-focal micro X-ray fluorescence measurements in situ in samples at high temperatures and pressures in diamond anvil cells (DAC) (e.g. Schmidt et al. 2007). The con-focal arrangement is used to suppress the background in X-ray fluorescence (XRF) spectra that stems from elastic and inelastic scattering of the diamond anvils. The setup is based on a focusing optic in the incident beam that reaches a spot of 5-10 ?m and a focusing poly-capillary in front of an energy-dispersive solid-state detector. The detector poly-capillary is designed to work at a very long working distance of 50 mm in order to collect the radiation from the center of the DAC at 90° to the incident beam. The probing volume is defined by the two foci and has a size of ca. 300 ?m at 8 keV and 150 ?m at 19 keV as measured by scans through thin metal foils. Comparison of XRF spectra acquired with a usual detector collimator and spectra recorded with the detector capillary shows a strong suppression of XRF signal generated outside the probed volume, i.e. XRF from the gasket material and signal from elastic and Compton scattering by the diamond anvils. The ratio of the Zr K-alpha fluorescence peak to the peak of the Compton scattering changes from 0.5 (collimator) to 1.26 (detector capillary) for a ca. 1000 ppm Zr standard solution and an incident beam energy of 20 keV. For a standard solution containing ca. 1000 ppm Hf, the ratio of the L-alpha to the Compton signal increases to 6 using the detector capillary and an incident beam energy of 9.7 keV. Thus, the con-focal setup substantially improves the fluorescence to background ratio. This will result in higher sensitivities for dilute elements in the sample chamber of the DAC. Furthermore, the possibilities of interference of the sample's signal with signal from the sample environment are greatly reduced. In a broader sense, the setup can also be applied to other confined samples that require long working distances. Schmidt et al. (2007) Lithos 95, 87-102

Wilke, Max; Rickers, Karen; Vincze, Laszlo; Schmidt, Christian; Borchert, Manuela; Pascarelli, Sakura



Multi-wall carbon nanotube-polyaniline biosensor based on lectin-carbohydrate affinity for ultrasensitive detection of Con A.  


In this paper, a novel method for detecting concanavalin A (Con A) was developed based on lectin-carbohydrate biospecific interactions. Multi-wall carbon nanotube-polyaniline (MWNT-PANI) nanocomposites, synthesized by in situ polymerization, were chosen to immobilize d-glucose through the Schiff-base reaction. The immobilized D-glucose showed high binding sensitivity and excellent selectivity to its target lectin, Con A. Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), transmission electron microscopy (TEM) and atomic force microscopy (AFM) were applied to characterize the assembly process of the modified electrode. Due to the high affinity of Con A for D-glucose and high stability of the propounded sensing platform, the fabricated biosensor achieved ultrasensitive detection of Con A with good sensitivity, acceptable reproducibility and stability. The changes of response current were proportional to the Con A concentrations from 3.3 pM to 9.3 nM, with a detection limit of 1.0 pM. Therefore, the combination of MWNT-PANI nanocomposites and the special binding force between lectin and carbohydrate provides an efficient and promising platform for the fabrication of bioelectrochemical devices. PMID:22387041

Hu, Fangxin; Chen, Shihong; Wang, Chengyan; Yuan, Ruo; Xiang, Yun; Wang, Cun



Methane activation by cobalt cluster cations, Con+ (n=2-16): Reaction mechanisms and thermochemistry of cluster-CHx (x=0-3) complexes  

NASA Astrophysics Data System (ADS)

The kinetic energy dependences of the reactions of Con+ (n=2-16) with CD4 are studied in a guided ion beam tandem mass spectrometer over the energy range of 0-10 eV. The main products are hydride formation, ConD+, dehydrogenation to form ConCD2+, and double dehydrogenation yielding ConC+. These primary products decompose to form secondary and higher order products, ConCD+, Con-1D+, Con-1C+, Con-1CD+, and Con-1CD2+ at higher energies. Adduct formation of ConCD4+ is also observed for the largest cluster cations, n>=10. In general, the efficiencies of the single and double dehydrogenation processes increase with cluster size, although the hexamer cation shows a reduced reactivity compared to its neighbors. All reactions exhibit thresholds, and cross sections for the various primary and secondary reactions are analyzed to yield reaction thresholds from which bond energies for cobalt cluster cations to D, C, CD, CD2, and CD3 are determined. The relative magnitudes of these bond energies are consistent with simple bond order considerations. Bond energies for larger clusters rapidly reach relatively constant values, which are used to estimate the chemisorption energies of the C, CD, CD2, and CD3 molecular fragments to cobalt surfaces.

Citir, Murat; Liu, Fuyi; Armentrout, P. B.



Pro-Con Debate: Etomidate or Ketamine for Rapid Sequence Intubation in Pediatric Patients  

PubMed Central

When caring for critically ill children, airway management remains a primary determinant of the eventual outcome. Airway control with endotracheal intubation is frequently necessary. Rapid sequence intubation (RSI) is generally used in emergency airway management to protect the airway from passive regurgitation of gastric contents. Along with a rapid acting neuromuscular blocking agent, sedation is an essential element of RSI. A significant safety concern regarding sedatives is the risk of hypotension and cardiovascular collapse, especially in critically ill patients or those with pre-existing comorbid conditions. Ketamine and etomidate, both of which provide effective sedation with limited effects on hemodynamic function, have become increasingly popular as induction agents for RSI. However, experience and clinical investigations have raised safety concerns associated with both etomidate and ketamine. Using a pro-con debate style, the following manuscript discusses the use of ketamine versus etomidate in RSI.

Scherzer, Daniel; Leder, Mark; Tobias, Joseph D.



Intramolecular Hydrogen Bond in Alkoxyamines. Influence on the C-ON Bond Homolysis.  


The C-ON bond homolysis in alkoxyamines can be influenced by the presence of an intramolecular hydrogen bond (IHB) between the alkyl and the nitroxyl fragments, which leads to an 8-fold decrease in the homolysis rate constant kd. When the IHB is disrupted by the solvent or by substitution of the hydrogen involved in the IHB by a protecting group (OMe, OAc, OBz, OBn, or OTBDMS), a higher homolysis rate constant kd is observed, as expected from the correlations developed by Marque ( Bertin , D. ; Gigmes , D. ; Marque , S. ; Tordo , P. Macromolecules 2005 , 38 , 2638 - 2650 ). Results were confirmed by DFT calculations at the B3LYP/6-31G(d,p) level. PMID:24070391

Brémond, Paul; Butscher, Teddy; Roubaud, Valérie; Siri, Didier; Viel, Stéphane



A maritime navigation display that provides visual feedback to improve conning officers' ship-handling during low visibility environments.  


Navigating a ship at night in close proximity to another vessel is a dangerous task. To improve conning officers' night time ship-handling performance, a visual navigation display is proposed that is mounted on the stern of the aircraft carrier that will help shipboard conning officers manoeuvre in a battle group formation. To test the effectiveness of the visual navigation display, the Nimitz-class aircraft and plane guard vessel, a Ticonderoga-class cruiser, were modelled in a virtual environment. A navigation display condition had significantly fewer navigational positional errors than a non-navigation display condition. The navigation display provided immediate feedback as to whether the aircraft carrier had changed bearing or speed, thus enabling the operator to initiate the appropriate input to maintain station astern of the carrier. Actual or potential applications of this research include the deployment of a maritime navigation display to assist conning officers' ship handling. PMID:12569043

Evanoff, Thomas V; Krebs, William K



Direct activation of murine resting T cells by con A or anti-CD3 Ig.  


The induction of antigen-specific T cell activation is highly dependent on accessory cells (AC) which present processed antigenic fragments associated with MHC molecules and provide costimulatory signals for T cells. Antigen-specific T cell activation requires cross-linking of the TCR and the reception of one or more nonantigen-specific signals which eventually lead to T cell activation and proliferation. This sequence of events can be mimicked by lectins, bacterial enterotoxins, and anti-TCR antibodies in conjunction with APC or the combination of phorbol esters and Ca ionophores. Although the combination of PMA + Ca ionophore and certain types of T-T interactions result in APC independent T cell activation, it is generally assumed that physiologic T cell activation requires APC. The seemingly direct activation of T cells by other T cells is rather surprising in view of the known APC dependence of antigen, lectin and anti-TCR mediated T cell activation. It is conceivable that T cell mediated T cell activation is due to "cryptic" APC contamination because the total absence of APC is difficult to disprove. In reality, neither total depletion nor residual contamination with APC can be proven or disproven experimentally. Thus it can be legitimately argued that both APC dependent and independent T cell activation occur, albeit under different experimental conditions. For instance, it is possible that APC independent activation of T cells by lectins and anti-TCR antibodies would require high concentrations of activators to overide their dependence on APC. It is also conceivable and, in our opinion quite likely, that once activated, T cells could propagate T cell activation through T-T interactions. In this report we test two hypotheses: (1) The triggering of resting T cells leading to autocrine cell proliferation depends entirely on cross-linking TCR molecules, and (2) The presence of activated T cells facilitates TCR mediated activation of resting T cells without the participation of conventional APC. We present evidence that highly purified, small resting T cells can be reproducibly activated with high doses of ConA, plastic bound anti-CD3 mab and its F(ab')2 fragments. This APC independent response results in blastic transformation, expression of the IL2 Receptor, the secretion of IL2 and significant proliferation of both CD4+ and CD8+ murine T cells. These observations demonstrate that vigorous cross-linking of TCRs by anti-CD3 mab and, presumably ConA, is sufficient to induce T cell activation and autocrine (IL2 driven) proliferation.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:2532886

Quintáns, J; Yokoyama, A; Evavold, B; Hirsch, R; Mayforth, R D



Contaminantes atmosféricos y su correlación con infecciones agudas de las vías respiratorias en niños de Guadalajara, Jalisco  

Microsoft Academic Search

Objective: To describe the correlation between the con- centration levels of atmospheric air pollutants and the num- ber of medical visits to IMSS, ISSSTE and of SSJ healthcare facilities of the Urban Area of Guadalajara between 2000- 2002 by children under five years suffering from acute res- piratory infections. Material and Methods: An ecological study was performed to describe the

Hermes Ulises Ramírez-Sánchez; María Dolores Andrade-García; Miguel Ernesto González-Castañeda; Alfredo de Jesús Celis-de la Rosa



Con-A-CNT (Carbon Nanotube) Conjugate with Short Wave Near-Infrared (SWIR) Laser Ablation for Tumor Therapy.  

National Technical Information Service (NTIS)

Using the characteristics of T cell mitogen called lectin protein from the jack-bean Canavalia ensiformis Concanavalin A (Con-A) with dual activities, cytotoxicity and immunomodulation, we have shown it has a therapeutic effect on hepatoma. Injection of C...

C. Peng H. Lei H. Szu M. Tang



The pros and cons of distant pedicled flaps for upper extremity trauma reconstruction in the era of microvascular surgery  

Microsoft Academic Search

Nineteen distant pedicled flaps, performed during 1989 for posttraumatic upper extremity soft tissue defect cover were reviewed. The pros and cons of distant pedicled flaps were examined with respect to the alternative treatment; namely, free microvascular tissue transfer. The main points considered were the traumatic defect, the donor site and particular problems of each patient. The conclusion was that pedicled

P. Graft; H. U. Steinau; G. Ingianni; E. Biemer



Considerazioni sulla proprieta' insulino-legante del siero del soggetto normale e del diabetico mai trattato con insulina  

Microsoft Academic Search

Riassunto Gli AA. rilevano che i sieri dell'individuo normale e del diabetico mai trattato con insulina sono provvisti di proprietà insulino-legante di entità analoga. In alcuni sieri, sia del soggetto normale che del diabetico, è presente un'attività insulino-legante superiore ai valori massimi normali, che diminuisce dopo aggiunta di µU 500 di insulina bovina.

Michele Lunetta; Giuseppe Calcagno; Luciano Motta; Turiddu Lombardo



Treatment of plutonium contaminated soil/sediment from the Mound site using the ACT*DE*CON{sup SM} process  

SciTech Connect

The removal and/or treatment of contaminated soil is a major problem facing the US DOE. The EG&G Mound Applied Technologies site in Miamisburg, Ohio, has an estimated 1.5 million cubic feet of soils from past disposal and waste burial practices awaiting remediation from plutonium contamination. This amount includes sediment from the Miami-Erie Canal that was contaminated in 1969 following a pipe- rupture accident. Conventional soil washing techniques that use particle separation would generate too large a waste volume to be economically feasible. Therefore, innovative technologies are needed for the cleanup. The ACT*DE*CON process was developed by SELENTEC for washing soils to selectively dissolve and remove heavy metals and radionuclides. ACT*DE*CON chemically dissolves and removes heavy metals and radionuclides from soils and sediments into an aqueous medium. The ACT*DE*CON process uses oxidative carbonate/chelant chemistry to dissolve the contaminant from the sediment and hold the contaminant in solution. The objective of recent work was to document the proves conditions necessary to achieve the Mound-site and regulatory-cleanup goals using the ACT*DE*CON technology.

Negri, M.C. [Argonne National Lab., IL (United States); Swift, N.A. [SELENTEC, Atlanta, GA (United States); North, J.P. [Rust Remedial Service, Inc., Anderson, SC (United States)



Juvenile Survival and Development in Euseius Finlandicus, Typhlodromus Pyri and Kampimodromus Aberrans (Acari: Phytoseiidae) Feeding on Con and Heterospecific Immatures  

Microsoft Academic Search

Juvenile survival and development in Euseius finlandicus (Oudemans), Typhlodromus pyri Scheuten and Kampimodromus aberrans (Oudemans) feeding on con- and heterospecific phytoseiid immatures were investigated in the laboratory at 25 ± 1 °C and 65 ± 5% RH. More than 50% of T. pyri protonymphs preying on larvae of K. aberrans or E. finlandicus reached the adult stage. The mean developmental

Peter Schausberger



Mecanismos psicofisiológicos implicados en la regulación afectiva y la restricción alimentaria de mujeres con riesgo de padecer bulimia nerviosa  

Microsoft Academic Search

El objetivo del estudio fue conocer el efecto de visualizar imágenes de comida bajo diferentes estados de ánimo y diferentes condiciones de restricción alimentaria en la modulación emocional de dos refle- jos defensivos (sobresalto motor y defensa cardiaca). 72 mujeres con riesgo de padecer bulimia ner- viosa fueron asignadas a dos grupos: 1) un grupo al que se inducía un

Sonia Rodríguez; José Luis Mata; Silvia Moreno; Jaime Vila




Microsoft Academic Search

El objeto del presente estudio es evaluar las diferencias en el gasto energético en la práctica de actividad física durante la jornada escolar y durante los fines de semana, y su relación con la autoestima en chicas adolescentes. Participaron 175 chicas entre 11 y 16 años, que cumplimentaron la Escala de Autoestima de Rosenberg, la Escala de Habilidad Física Percibida

Molinero González; Martínez García; Martín Ardura; M. Bragança; Salguero del Valle; Márquez Rosa


Present-day stress and pore pressure fields in the Cuu Long and Nam Con Son Basins, offshore Vietnam  

Microsoft Academic Search

Knowledge of the in situ, or contemporary stress field is vital for planning optimum orientations of deviated and horizontal wells, reservoir characterization and a better understanding of geodynamic processes and their effects on basin evolution.This study provides the first documented analysis of in situ stress and pore pressure fields in the sedimentary formations of the Cuu Long and Nam Con

Nguyen Thi Thanh Binh; Tomochika Tokunaga; Hoang Phuoc Son; Mai Van Binh



The use of the Pros and Cons of Anorexia Nervosa (P-CAN) Scale with children and adolescents  

Microsoft Academic Search

Objective: The Pros and Cons of Anorexia Nervosa (P-CAN) Scale was developed out of a previous qualitative study [Int J Eat Disord 25 (1999) 177] in which the positive and negative aspects of anorexia nervosa (AN) were elicited from individuals with AN. Principal components analysis was then used in an adult sample to reduce the number of items and to

Lucy Serpell; Marc Neiderman; Emma Haworth; Francesca Emmanueli; Bryan Lask



Strains arising by seismic events in the SIRGAS-CON network region  

NASA Astrophysics Data System (ADS)

In this study, we investigate surface strains related to seismic events and their relationship with pre- and post-seismic events in Latin America, by analyzing the variation of estimated earth coordinates supplied by a geodetic network called SIRGAS-CON. Based on data provided by the USGS for the period 2000-2011, and after the Global Congruency test, we selected four events associated with unstable geodetic network points. The resulting strains were estimated based on the finite element method using networks of points considered unstable connected to neighboring points using the Delaunay triangulation. It was possible to determine the strains along with the resulting guidelines for pre- and post-seismic, considering each triangular lattice formed for analysis as a homogeneous solid body. The calculation of strains and verification of the results allowed to analyze the interactions between lithospheric plates from the contraction and extension directions between points located in different plates. Despite the association between seismic events and the strain of geodetic network, some events of magnitude greater than 5.8 Mw were excluded because it does not show (provide) the surface strain, which is located at great depths. It was confirmed that events of greater magnitude provide increased surface strain rate when compared with other similar depths.

Marotta, G. S.; França, G. S.; Monico, J. F. G.; Fuck, R. A.



Long-Acting Injectable Antipsychotics for First-Episode Schizophrenia: The Pros and Cons  

PubMed Central

Clinical and psychosocial deterioration associated with schizophrenia occurs within the first few years following the onset of the illness. Therefore, to improve the long-term prognosis, it is important to provide schizophrenia patients with intensive treatment following their first episode. Relapse is highly associated with partial medication adherence or nonadherence in patients with first-episode schizophrenia. Recent studies suggest that long-acting injectable (LAI) antipsychotics compared with oral antipsychotics are more effective for medication adherence and relapse prevention. Moreover, some clinical guidelines for the treatment of schizophrenia suggested that LAI antipsychotics should be considered when patients are nonadherent “at any stage.” Decreased compliance is a common cause of relapse during the initial stages of the disease. Therefore, LAI antipsychotics should be highly considered when treating patients with first-episode schizophrenia. In the present paper, clinical trial data and current guidelines on the use of LAI antipsychotics for first-episode schizophrenia are discussed as well as the pros and cons of this treatment option.

Kim, Borah; Lee, Sang-Hyuk; Yang, Yen Kuang; Park, Jong-Il; Chung, Young-Chul



Pro con debate: the use of regional vs systemic analgesia for neonatal surgery.  


In recent years the inclusion of regional techniques to pediatric anesthesia has transformed practice. Simple procedures such as caudal anesthesia with local anaesthetics can reduce the amounts of general anesthesia required and provide complete analgesia in the postoperative period while avoiding large amounts of opioid analgesia with potential side effects that can impair recovery. However, the application of central blocks (epidural and spinal local anesthesia) via catheters in the younger infant, neonate and even preterm neonate remains more controversial. The potential for such invasive maneuvers themselves to augment risk, can be argued to outweigh the benefits, others would argue that epidural analgesia can reduce the need for postoperative ventilation and that this not only facilitates surgery when intensive care facilities are limited, but also reduces cost in terms of PICU stay and recovery profile. Currently, opinions are divided and strongly held with some major units adopting this approach widely and others maintaining a more conservative stance to anesthesia for major neonatal surgery. In this pro-con debate the evidence base is examined, supplemented with expert opinion to try to provide a balanced overall view. PMID:21722227

Bösenberg, Adrian T; Jöhr, Martin; Wolf, Andrew R



[Emission spectrum of liquid CO-N2 mixture at shock compression].  


Driving a copper projectile to impact a cryo-target made of aluminous alloy at the speed of 2.21 km x s(-1) with a two stage light gas gun, a proper one dimensional shockwave with a speed of 18.76 km x s(-1) was generated and directly acted on a uniform liquid in target, which was condensed by proportional gaseous carbon monoxide and nitrogen. At the measurement of Hugoniots, the full linear spectrum entirely dissociated with the plasma under the shock pressure of 33.5 GPa was caught by the use of intensified charge coupled device and accurate spectrographic technology. From the analysis of the spectrum, the authors know that the transient spectrograph with six channels can be used to measure and record the course of shock compression-irradiancy reliably, and the emitted spectral lines of shock compressed products indicated that the thermal dissociation and phase transition had occurred in homogeneous liquid of CO-N2. Furthermore, comparing the spectral intensity of lower central wavelength with that of higher, the fact of stronger intensity of 488 nm also validates that changes from "optic thin" to "optic thick" exist indeed in dense hydrocarbon liquid acted on by shock pressure. PMID:19626860

Sun, Yue; Yi, Peng-Fei; Chen, Xian-Meng; Liu, Fu-Sheng; Zhang, Ming-Jian; Zheng, Xue-Ping; Xue, Xue-Dong



Chemically triggered C-ON bond homolysis in alkoxyamines: regioselectivity and chemoselectivity.  


Recently, we examplified the activation of the C-ON bond homolysis by protonation, alkylation, benzylation, acylation, oxidation and complexation with a Lewis acid of the nitrogen atom of the 1-(pyridin-4-yl)ethyl fragment (Chem. Commun., 2011, 4291 and Org. Lett., 2012, 358) and of the 1-(pyridin-2-yl)ethyl fragment (J. Org. Chem. ASAP Doi:10.1021/jo401674v) of (N-(2-methylpropyl)-N-(1-diethylphosphono-2,2-dimethylpropyl)-N-oxyl) SG1-based alkoxyamines. The quaternization of the 1-(pyridin-3-yl)ethyl fragment by the aforementioned reactions was investigated for the corresponding SG1-based alkoxyamines. In sharp contrast to the quaternization at ortho and para positions of the pyridyl moiety, the effect of the quaternization at the meta position was weak. The effects of quaternization at ortho, meta and para positions were investigated through natural bond orbital and Mulliken charges, HOMO-LUMO interactions in the starting materials and the radical stabilization energy of the released 1-puridylmethyl radicals using DFT calculations with the B3LYP/6-31G(d) and UBMK/6-311+G(3df,2p)//R(O)B3LYP/6-31G(d) methods, respectively. PMID:24114038

Audran, Gérard; Brémond, Paul; Ibanou, Matisse Bim Batsiandzy; Marque, Sylvain R A; Roubaud, Valérie; Siri, Didier




Microsoft Academic Search

. La fotocorriente inducida por iluminación pulsada, de un capacitor MOS con compuerta de Mo, provisto de ventana óptica, se emplea como monitor de su estado de carga, frente a estímulos químicos con concentraciones crecientes de H2 en N2 de hasta 1000 ppm. Se describen las respuestas inducidas por transporte a la interfaz metal-dieléctrico. Los resultados confirman que la sensibilidad

R. M. Lombardi; R. Aragón


Do Patient-perceived Pros and Cons of Opioids Predict Sustained Higher-Dose Use?  


OBJECTIVES:: Chronic opioid therapy (COT) is associated with various adverse outcomes, especially at higher doses, yet little is known about predictors of sustained higher-dose COT. This study aimed to ascertain, among higher-dose COT patients, the association of patient-perceived pros and cons of opioids with continued higher-dose use 1 year later. METHODS:: Patients (N=1229) in 2 large health plans prescribed ?50 mg morphine-equivalent dose (MED) per day for chronic noncancer pain completed a survey assessing opioid benefits and harms. The Prescribed Opioid Difficulties Scale questionnaire assessed psychosocial problems, concerns, benefits, and side effects related to opioid use. Logistic regression models estimated the associations of the reported benefits and problems with higher-dose continuation (?50 mg MED/d) versus dose reduction (<50 mg MED/d) 1 year later. RESULTS:: Over 80% of participants continued higher-dose opioid use at 1 year, regardless of reported problems, concerns, side effects, pain reduction, or perceived helpfulness. Higher scores on the Prescribed Opioid Difficulties Scale Problems subscale (odds ratio=0.79, 95% confidence interval, 0.68-0.92) and Concerns subscale (odds ratio=0.76, 95% confidence interval, 0.65-0.90) were negatively associated with higher-dose use 1 year later. Other baseline measures (opioid helpfulness, reduction in pain, number of side effects, and side effect bothersomeness) were not significantly associated with continued higher-dose use. DISCUSSION:: The large majority of patients continued using higher-dose opioids regardless of baseline characteristics. These findings suggest the difficulty of reducing opioid dose among chronic higher-dose opioid users. PMID:23535150

Thielke, Stephen M; Turner, Judith A; Shortreed, Susan M; Saunders, Kathleen; Leresche, Linda; Campbell, Cynthia I; Weisner, Constance C; Korff, Michael Von



Strain rate of the South American lithospheric plate by SIRGAS-CON geodetic observations  

NASA Astrophysics Data System (ADS)

A multiyear solution of the SIRGAS-CON network was used to estimate the strain rates of the earth surface from the changing directions of the velocity vectors of 140 geodetic points located in the South American plate. The strain rate was determined by the finite element method using Delaunay triangulation points that formed sub-networks; each sub-network was considered a solid and homogeneous body. The results showed that strain rates vary along the South American plate and are more significant on the western portion of the plate, as expected, since this region is close to the subduction zone of the Nazca plate beneath the South American plate. After using Euler vectors to infer Nazca plate movement and to orient the velocity vectors of the South American plate, it was possible to estimate the convergence and accommodation rates of the Nazca and South American plates, respectively. Strain rate estimates permitted determination of predominant contraction and/or extension regions and to establish that contraction regions coincide with locations with most of the high magnitude seismic events. Some areas with extension and contraction strains were found to the east within the stable South American plate, which may result from different stresses associated with different geological characteristics. These results suggest that major movements detected on the surface near the Nazca plate occur in regions with more heterogeneous geological structures and multiple rupture events. Most seismic events in the South American plate are concentrated in areas with predominant contraction strain rates oriented northeast-southwest; significant amounts of elastic strain can be accumulated on geological structures away from the plate boundary faults; and, behavior of contractions and extensions is similar to what has been found in seismological studies.

Marotta, Giuliano Sant'Anna; França, George Sand; Galera Monico, João Francisco; Fuck, Reinhardt Adolfo; Oswaldo de Araújo Filho, José



Iliac crest autograft versus alternative constructs for anterior cervical spine surgery: Pros, cons, and costs  

PubMed Central

Background: Grafting choices available for performing anterior cervical diskectomy/fusion (ACDF) procedures have become a major concern for spinal surgeons, and their institutions. The “gold standard”, iliac crest autograft, may still be the best and least expensive grafting option; it deserves to be reassessed along with the pros, cons, and costs for alternative grafts/spacers. Methods: Although single or multilevel ACDF have utilized iliac crest autograft for decades, the implant industry now offers multiple alternative grafting and spacer devices; (allografts, cages, polyether-etherketone (PEEK) amongst others). While most studies have focused on fusion rates and clinical outcomes following ACDF, few have analyzed the “value-added” of these various constructs (e.g. safety/efficacy, risks/complications, costs). Results: The majority of studies document 95%-100% fusion rates when iliac crest autograft is utilized to perform single level ACDF (X-ray or CT confirmed at 6-12 postoperative months). Although many allograft studies similarly quote 90%-100% fusion rates (X-ray alone confirmed at 6-12 postoperative months), a recent “post hoc analysis of data from a prospective multicenter trial” (Riew KD et. al., CSRS Abstract Dec. 2011; unpublished) revealed a much higher delayed fusion rate using allografts at one year 55.7%, 2 years 87%, and four years 92%. Conclusion: Iliac crest autograft utilized for single or multilevel ACDF is associated with the highest fusion, lowest complication rates, and significantly lower costs compared with allograft, cages, PEEK, or other grafts. As spinal surgeons and institutions become more cost conscious, we will have to account for the “value added” of these increasingly expensive graft constructs.

Epstein, Nancy E.



Plasmonic tunable glucose sensing based on the dissociation of Con A-aggregated dextran-coated gold colloids  

NASA Astrophysics Data System (ADS)

We have recently developed a new approach to glucose sensing based on the aggregation of nanometer-sized noble-metal nanoparticles and their respective change in plasmon absorption upon glucose addition. High molecular weight Dextran coated nanoparticles are aggregated with Concanavalin A, (Con A), where the aggregation results in a significant shift in metal-plasmon absorption. The addition of glucose competitively binds to Con A, reducing nanoparticle aggregation, and therefore the plasmon absorption when monitored at 650 nm. We have optimized our plasmonic glucose sensing mechanism with regard to nanoparticle stability, the dynamic range for glucose sensing and the wavelength of observation, to be compatible with both clinical glucose requirements and measurements.

Geddes, Chris D.; Aslan, Kadir; Zhang, Jian; Lakowicz, Joseph R.



Structural analysis of ConBr reveals molecular correlation between the carbohydrate recognition domain and endothelial NO synthase activation.  


Diocleinae lectins are highly homologous in their primary structure which features metal binding sites and a carbohydrate recognition domain (CRD). Differences in the biological activity of legume lectins have been widely investigated using hemagglutination inhibition assays, isothermal titration microcalorimetry and co-crystallization with mono- and oligosaccharides. Here we report a new lectin crystal structure (ConBr) extracted from seeds of Canavalia brasiliensis, predict dimannoside binding by docking, identify the ?-aminobutyric acid (Abu) binding pocket and compare the CRD of ConBr to that of homologous lectins. Based on the hypothesis that the carbohydrate affinity of lectins depends on CRD configuration, the relationship between tridimensional structure and endothelial NO synthase activation was used to clarify differences in biological activity. Our study established a correlation between the position of CRD amino acid side chains and the stimulation of NO release from endothelium. PMID:21530490

Bezerra, Eduardo Henrique Salviano; Rocha, Bruno Anderson Matias; Nagano, Celso Shiniti; Bezerra, Gustavo de Arruda; Moura, Tales Rocha de; Bezerra, Maria Júlia Barbosa; Benevides, Raquel Guimarães; Sampaio, Alexandre Holanda; Assreuy, Ana Maria Sampaio; Delatorre, Plínio; Cavada, Benildo Sousa



Long-Term Efficacy and Reproductive Behavior Associated with GonaCon ? Use in White-Tailed Deer (Odocoileus virginianus )  

Microsoft Academic Search

GonaCon ? is a single-shot immunocontraceptive vaccine that targets the reproductive hormone gonadotropin releasing hormone (GnRH). The GnRH peptide used in the vaccine is secreted by the hypothalamus of the brain and is specifically known as luteinizing hormone releasing hormone. This peptide stimulates the synthesis and secretion of luteiniz- ing hormone and follicle stimulating hormone by the anterior pituitary gland.

Gary Killian


Comparison of four probabilistic models (CARES(®), Calendex™, ConsExpo, and SHEDS) to estimate aggregate residential exposures to pesticides.  


Two deterministic models (US EPA's Office of Pesticide Programs Residential Standard Operating Procedures (OPP Residential SOPs) and Draft Protocol for Measuring Children's Non-Occupational Exposure to Pesticides by all Relevant Pathways (Draft Protocol)) and four probabilistic models (CARES(®), Calendex™, ConsExpo, and SHEDS) were used to estimate aggregate residential exposures to pesticides. The route-specific exposure estimates for young children (2-5 years) generated by each model were compared to evaluate data inputs, algorithms, and underlying assumptions. Three indoor exposure scenarios were considered: crack and crevice, fogger, and flying insect killer. Dermal exposure estimates from the OPP Residential SOPs and the Draft Protocol were 4.75 and 2.37?mg/kg/day (crack and crevice scenario) and 0.73 and 0.36?mg/kg/day (fogger), respectively. The dermal exposure estimates (99th percentile) for the crack and crevice scenario were 16.52, 12.82, 3.57, and 3.30?mg/kg/day for CARES, Calendex, SHEDS, and ConsExpo, respectively. Dermal exposure estimates for the fogger scenario from CARES and Calendex (1.50 and 1.47?mg/kg/day, respectively) were slightly higher than those from SHEDS and ConsExpo (0.74 and 0.55?mg/kg/day, respectively). The ConsExpo derived non-dietary ingestion estimates (99th percentile) under these two scenarios were higher than those from SHEDS, CARES, and Calendex. All models produced extremely low exposure estimates for the flying insect killer scenario. Using similar data inputs, the model estimates by route for these scenarios were consistent and comparable. Most of the models predicted exposures within a factor of 5 at the 50th and 99th percentiles. The differences identified are explained by activity assumptions, input distributions, and exposure algorithms. PMID:22781436

Young, Bruce M; Tulve, Nicolle S; Egeghy, Peter P; Driver, Jeffrey H; Zartarian, Valerie G; Johnston, Jason E; Delmaar, Christiaan J E; Evans, Jeffrey J; Smith, Luther A; Glen, Graham; Lunchick, Curt; Ross, John H; Xue, Jianping; Barnekow, David E



The politics of energy: Case study of Con Edison's nuclear complex at Indian Point, New York. Working paper  

Microsoft Academic Search

The possible impact of areawide residential location policy on future residential electricity usage in the Tri-State Metropolitan Region centering on New York City is investigated. This paper focuses on the politics of energy in its discussion of Con Edison's Nuclear Complex at Indian Point. The first period of planning (1954 to the late 60's) comprised a relatively closed decision-making process

J. Aron; K. Seelman



Evaluating the decisional balance construct of the Transtheoretical Model: are two dimensions of pros and cons really enough?  

Microsoft Academic Search

Objectives  The Transtheoretical Model of behavior change (TTM) postulates that behavior change is a process involving progress through\\u000a five distinct stages of change (SOC). One of the key components for progress to a later stage is decisional balance (pros\\u000a and cons of changing to the target behavior). The goal of the present study is to test the two dimensions of decisional

Chantal Kroll; Roger Keller; Urte Scholz; Sonja Perren



Mitochondria-Dependent Apoptosis of Con A-Activated T Lymphocytes Induced by Asiatic Acid for Preventing Murine Fulminant Hepatitis  

PubMed Central

Selectively facilitating apoptosis of activated T cells is essential for the clearance of pathogenic injurious cells and subsequent efficient resolution of inflammation. However, few chemicals have been reported to trigger apoptosis of activated T cells for the treatment of hepatitis without affecting quiescent T cells. In the present study, we found that asiatic acid, a natural triterpenoid, selectively triggered apoptosis of concanavalin A (Con A)-activated T cells in a mitochondria-dependent manner indicated by the disruption of the mitochondrial transmembrane potential, release of cytochrome c from mitochondria to cytosol, caspases activation, and cleavage of PARP. In addition, asiatic acid also induced the cleavage of caspase 8 and Bid and augmented Fas expression in Con A-activated T cells. However, following activation of T cells from MRLlpr/lpr mice with mutation of Fas demonstrated a similar susceptibility to asiatic acid-induced apoptosis compared with normal T cells, suggesting that Fas-mediated death-receptor apoptotic pathway does not mainly contribute to asiatic acid-induced cell death. Furthermore, asiatic acid significantly alleviated Con A-induced T cell-dependent fulminant hepatitis in mice, as assessed by reduced serum transaminases, pro-inflammatory cytokines, and pathologic parameters. Consistent with the in vitro results, asiatic acid also induced apoptosis of activated CD4+ T cells in vivo. Taken together, our results demonstrated that the ability of asiatic acid to induce apoptosis of activated T cells and its potential use in the treatment of T-cell-mediated inflammatory diseases.

Guo, Wenjie; Liu, Wen; Hong, Shaocheng; Liu, Hailiang; Qian, Cheng; Shen, Yan; Wu, Xuefeng; Sun, Yang; Xu, Qiang




Microsoft Academic Search

Current agricultural production in Los Altos de Chiapas region faces some problems such as soil erosion and loss of fertility, di- minishment of work productivity and increasing incapacity to pro- vide work and basic food for family members. These problems are the result of an excessive pressure on the land, the irregular topog- raphy, the agricultural land dispersion and atomization,

Luciano Pool-Novelo; Antonio Trinidad-Santos; Jorge D. Etchevers-Barra; Jesús Pérez-Moreno; Angel Martínez-Garza




Microsoft Academic Search

Arbuscular mycorrhizal colonization and nodulation in cowpea (Vigna unguiculata L.Walp) plants growing in soils under alley-cropping, low-input continuous cropping, secondary forest, and bare soil on a slope were evaluated at 5, 15, 30 and 45 days after seed germination (DASG) under greenhouse conditions. Mycorrhizal colonization and nodulation in cowpeas differed greatly at their early growth stages in spite that any

Pedro O. Ruiz; Charles B. Dave


Anti-human IG and B lymphocytes reconstitute the proliferative response to Con A of T lymphocytes depleted of accessory cells  

SciTech Connect

The requirements for the induction of proliferation of human peripheral blood mononuclear cells (PBM) by low concentrations of Concanavalin A (Con A) were studied using /sup 3/H-thymidine incorporation to assay DNA synthesis. Removal of plastic-adherent cells from PBM reduced the proliferative response of lymphocytes to Con A by 80%. Passage of these cells over nylon wool columns totally eliminated their response to Con A. Addition of adherent monocytes or rabbit anti-human IgG conjugated to polyacrylamide beads (anti-IgG beads) to the non-adherent lymphocyte population reconstituted the proliferative response. The lymphoblasts activated in these cultures were more than 90% T11 positive. Anti-IgG beads did not activate lymphocyte proliferation in the absence of Con A. The response of non-adherent lymphocytes to Con A could also be reconstituted by unconjugated rabbit anti-human IgG antiserium. Purified T cells could only be activated by anti-IgG beads and low concentrations of Con A in the presence of irradiated B cells. These results suggest that /sup 3/H-thymidine incorporation by T cells induced by anti-IgG beads and a low concentration of Con A depends on the interaction of anti-IgG and B cells. The authors suggest that B cell produce growth factors for T cells after interacting with anti-IgG.

Tsuda, T.; Kim, Y.T.; Schwab, R.; Siskind, G.W.; Weksler, M.E.



Calcium balance in haemodialysis--do not lower the dialysate calcium concentration too much (con part).  


The debate on the most adequate dialysate calcium concentration for intermittent haemodialysis therapy is ongoing. There is probably no one optimal concentration. In general, one would like to maintain a neutral calcium balance in adult haemodialysis patients. However, a slightly negative balance may be preferable to avoid soft-tissue calcium accumulation in face of net calcium loss from the bone with ageing. The problem with measurements of calcium balance is that they are generally imprecise, as are estimations of total body calcium and its distribution in various compartments, unless done with labour-intensive methods and great care. The choice of the dialysate calcium will depend on several factors, including parathyroid and vitamin D status, type and severity of concomitant bone disease, presence or absence of arterial calcification, dietary habits, drug treatment and dialysis modality. Ideally the dialysate calcium would be adapted to each patient's needs. This is not feasible, however, in most dialysis settings and neither is it cost-effective. From a practical point of view, a relatively high dialysate calcium concentration in the range of of 1.50-1.75 mmol/L (3.0-3.5 mEq/L) should probably be preferred in haemodialysis patients with high serum PTH levels who are not prescribed calcium-based phosphate binders or high doses of active vitamin D sterols, and in those who are receiving a calcimimetic. In those who are treated with high doses of calcium-based binders and/or active vitamin D derivatives or who have a very low serum PTH level, the optimal dialysate calcium concentration is probably lower, in the range of 1.25-1.50 mmol/L (2.50-3.0 mEq/L). In the present pro/con debate about the optimal dialysate calcium concentration used for the haemodialysis session, we have accepted to defend the viewpoint that a low calcium concentration may do more harm than benefit in many patients. This viewpoint is opposite to that taken by Gotch. He argues that since calcitriol and other active vitamin D derivatives have become available virtually all haemodialysis patients are in positive calcium balance. We would like to take issue with this statement and warn against the indiscriminate use of a low calcium dialysate in all patients receiving haemodialysis therapy. PMID:19666667

Drüeke, Tilman B; Touam, Malik



Use of colloidal gold and ruthenium red in stereo high-voltage electron microscopic study of Con A-binding sites in mouse macrophages  

Microsoft Academic Search

Concanavalin A (Con A)-binding sites were labeled with colloidal gold (CG), stained with ruthenium red, and observed under a high-voltage electron microscope. Mouse peritoneal macrophages were labeled by the indirect Con A\\/CG labeling method at 0° C. After washing, some of the cells were incubated in phosphate-buffered saline (PBS) at 37° C. The specimens were then stained with ruthenium red,

K. Takata; T. Arii; S. Yamagishi; H. Hirano



Lectin from Canavalia brasiliensis seeds (ConBr) is a valuable biotechnological tool to stimulate the growth of Rhizobium tropici in vitro.  


To study the interactions between a Rhizobium tropici strain and lectins isolated from the seeds of Canavalia ensiformis (ConA) and Canavalia brasiliensis (ConBr), a lectin fluorescence assay was performed. In addition, an experiment was designed to evaluate the effect of the two lectins on bacterial growth. Both lectins were found to bind to R. tropici cells, but the interactions were inhibited by D-mannose. Interestingly, only ConBr stimulated bacterial growth in proportion to the concentrations used (15.6-500 ?g/mL), and the bacterial growth stimulation was inhibited by D-mannose as well. Structure/Function analyses by bioinformatics were carried out to evaluate the volume and carbohydrate recognition domain (CRD) configuration of ConA and ConBr. The difference of spatial arrangement and volume of CRD may indicate the variation between biological activities of both lectins. The results suggest that ConBr could be a promising tool for studies focusing on the interactions between rhizobia and host plants. PMID:22565477

de Vasconcelos, Mayron Alves; Cunha, Claudio Oliveira; Arruda, Francisco Vassiliepe Sousa; Carneiro, Victor Alves; Mercante, Fabio Martins; do Nascimento Neto, Luiz Gonzaga; de Sousa, Giselly Soares; Rocha, Bruno Anderson Matias; Teixeira, Edson Holanda; Cavada, Benildo Sousa; dos Santos, Ricardo Pires



CONS-COCOMAPS: a novel tool to measure and visualize the conservation of inter-residue contacts in multiple docking solutions  

PubMed Central

Background The development of accurate protein-protein docking programs is making this kind of simulations an effective tool to predict the 3D structure and the surface of interaction between the molecular partners in macromolecular complexes. However, correctly scoring multiple docking solutions is still an open problem. As a consequence, the accurate and tedious screening of many docking models is usually required in the analysis step. Methods All the programs under CONS-COCOMAPS have been written in python, taking advantage of python libraries such as SciPy and Matplotlib. CONS-COCOMAPS is freely available as a web tool at the URL: Results Here we presented CONS-COCOMAPS, a novel tool to easily measure and visualize the consensus in multiple docking solutions. CONS-COCOMAPS uses the conservation of inter-residue contacts as an estimate of the similarity between different docking solutions. To visualize the conservation, CONS-COCOMAPS uses intermolecular contact maps. Conclusions The application of CONS-COCOMAPS to test-cases taken from recent CAPRI rounds has shown that it is very efficient in highlighting even a very weak consensus that often is biologically meaningful.



Co-adsorptions of CO/N2O, NO/NH3, CO2/N2 and conversion of CO/N2O to CO2/N2 on ZnO graphene-like nanosheet  

NASA Astrophysics Data System (ADS)

Adsorption energies of CO, CO2, N2O, N2, NO, NH3 and CO/N2O, NO/NH3 and CO2/N2 co-adsorptions on the ZnO graphene-like nanosheet (ZnOGLNS) were obtained using DFT calculations. The energies and thermodynamic properties for conversion of CO + N2O to CO2 + N2 over the ZnOGLNS, its equilibrium constant and adsorption coefficients are reported. The activation energy for the conversion reaction of CO + N2O to CO2 + N2 over the ZnOGLNS of 42.30 kcal/mol was obtained. The CO + N2O to CO2 + N2 conversion over the ZnOGLNS is the energetically and thermodynamically preferred reaction.

Kaewruksa, Benjawan; Wanbayor, Raina; Ruangpornvisuti, Vithaya



[Intracranial hypertension related to sedation with sevoflurane using the AnaConDa(®) device in a patient with severe traumatic brain injury].  


Sedation in neurocritical patients remains a challenge as there is no drug that meets all the requirements. Since the appearance of the AnaConDa(®) device, and according to the latest recommendations, sevoflurane has become an alternative for patients with brain injury. The use of AnaConDa(®) produces an increase in the anatomical dead space that leads to a decrease in alveolar ventilation. If the decrease in the alveolar ventilation is not offset by an increase in minute volume, there will be an increase in PaCO2. We report the case of a patient with severe traumatic brain injury who suffered an increase in intracranial pressure as a result of increased PaCO2 after starting sedation with the AnaConDa(®) device. PMID:22920835

Ferrando, C; Carbonell, J A; Aguilar, G; Badenes, R; Belda, F J



Lectin from Canavalia brasiliensis (ConBr) protects hippocampal slices against glutamate neurotoxicity in a manner dependent of PI3K/Akt pathway.  


The excitotoxicity induced by excessive activation of the glutamatergic neurotransmission pathway is involved in several neuropathologies. In this sense, molecules that prevent the release of glutamate or the excessive activation of its receptors can be useful in preventing the neuronal cell death observed in these diseases. Lectins are proteins capable of reversible binding to the carbohydrates in glycoconjugates, and some have been used in the study and purification of glutamate receptors. ConBr is a mannose/glucose-binding lectin purified from Canavalia brasiliensis seeds. In the present study, we aimed to evaluate the neuroprotective activity of ConBr against glutamate-induced excitotoxicity. Hippocampal slices were isolated from adult male mice and incubated for 6h in Krebs saline/DMEM buffer alone (control), in the presence of glutamate or glutamate plus ConBr. The phosphorylation of Akt and mitogen activated protein kinases (MAPKs) such as ERK1/2, p38(MAPK) and JNK1/2/3 was evaluated with western blotting. The results indicate that glutamate provoked a reduction in the hippocampal slice viability (-25%), diminished the phosphorylation of Akt and augmented p38(MAPK) and ERK1 phosphorylation. No changes were observed in the phosphorylation of JNK1/2/3 or ERK2. Notably, ConBr, through a mechanism dependent on carbohydrate interaction, prevented the reduction of cell viability and Akt phosphorylation induced by glutamate. Furthermore, in the presence of the PI3K inhibitor LY294002, ConBr was unable to reverse glutamate neurotoxicity. Taken together, our data suggest that the neuroprotective effect of ConBr against glutamate neurotoxicity requires oligosaccharide interaction and is dependent on the PI3K/Akt pathway. PMID:23454192

Jacques, Amanda V; Rieger, Débora K; Maestri, Mariana; Lopes, Mark W; Peres, Tanara V; Gonçalves, Filipe M; Pedro, Daniela Z; Tasca, Carla I; López, Manuela G; Egea, Javier; Nascimento, Kyria S; Cavada, Benildo S; Leal, Rodrigo B



Preventive effects of 1,25-(OH)2VD3 against ConA-induced mouse hepatitis through promoting vitamin D receptor gene expression  

Microsoft Academic Search

Aim:To investigate the immunosuppressive effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2VD3) on concanavalin A (ConA)-induced hepatitis and elucidate the action mechanism.Methods:Female BALB\\/C mice were intravenously administered ConA (20 mg\\/kg) to induce acute immunological liver injury. Liver damage was evaluated in respect to serum alanine transaminase (ALT) level and liver histological changes. The proliferation of splenocytes was measured by using [3H]-thymidine incorporation. The

Xu-dong Hu; Shi-li Jiang; Cheng-hai Liu; Yi-yang Hu; Cheng Liu; Ming-yu Sun; Gao-feng Chen; Ping Liu



Crystal structure of [Co(N 2 C 2 H 8 ) 3 ] [AuBr 4 ] 2 Br bis (tetrabromoaurate(III)) tris (ethylenediamine) cobalt(III) bromide  

Microsoft Academic Search

A double complex salt [Co(N2C2H8)3][AuBr4]2Br is obtained and characterized using single crystal X-ray diffraction analysis. The crystallographic data of C6H24Au2Br9CoN6 are as follows: a = 21.6479(17) Å, b = 14.9085(12) Å, c = 8.2676(7) Å, ? = 110.820(2)°, V = 1538.92(12) Å3, C2\\/c space group, Z = 4, d\\u000a x = 3.602 g\\/cm3. Square planar coordination of the gold atom

I. A. Baidina; E. V. Makotchenko



Synthesis, growth, structural, spectral, thermal, chemical etching, linear and nonlinear optical and mechanical studies of an organic single crystal 4-chloro 4-nitrostilbene (CONS): a potential NLO material.  


4-Chloro 4-nitrostilbene (CONS) a new organic nonlinear optical material has been synthesized. Employing slow evaporation method, good optical quality single crystals (dimensions up to 6×2×3 mm(3)) have been grown using ethyl methyl ketone (EMK) as a solvent. The grown crystals have been subjected to various characterizations such as single crystal X-ray diffraction, powder XRD, Fourier Transform Infrared spectroscopy (FTIR), proton NMR, solid UV absorption, SHG studies. Single crystal X-ray diffraction reveals that the crystal system belongs to monoclinic with noncentrosymmetric space group P21. The UV-Vis absorption spectrum has been recorded and found that the cut off wavelength is 380 nm. Functional groups and the structure of the title compound have been confirmed by FTIR and (1)H NMR spectroscopic analyses respectively. Molecular mass of the CONS confirmed by the high resolution mass spectral analysis .The thermal behavior of the grown crystal has been studied by TG/DTA analysis and it shows the melting point is at 188.66 °C. Dislocations and growth pattern present in the grown crystal revealed by the etching study. The mechanical strength of the CONS crystal has been studied by Vicker's hardness measurement. The SHG efficiency of the grown crystal has been determined by Kurtz and Perry powder test which revealed that the CONS crystal (327 mV) has 15 times greater efficiency than that of KDP (21.7 mV). PMID:23624038

Dinakaran, Paul M; Kalainathan, S



Synthesis, growth, structural, spectral, thermal, chemical etching, linear and nonlinear optical and mechanical studies of an organic single crystal 4-chloro 4-nitrostilbene (CONS): A potential NLO material  

NASA Astrophysics Data System (ADS)

4-Chloro 4-nitrostilbene (CONS) a new organic nonlinear optical material has been synthesized. Employing slow evaporation method, good optical quality single crystals (dimensions up to 6 × 2 × 3 mm3) have been grown using ethyl methyl ketone (EMK) as a solvent. The grown crystals have been subjected to various characterizations such as single crystal X-ray diffraction, powder XRD, Fourier Transform Infrared spectroscopy (FTIR), proton NMR, solid UV absorption, SHG studies. Single crystal X-ray diffraction reveals that the crystal system belongs to monoclinic with noncentrosymmetric space group P21. The UV-Vis absorption spectrum has been recorded and found that the cut off wavelength is 380 nm. Functional groups and the structure of the title compound have been confirmed by FTIR and 1H NMR spectroscopic analyses respectively. Molecular mass of the CONS confirmed by the high resolution mass spectral analysis .The thermal behavior of the grown crystal has been studied by TG/DTA analysis and it shows the melting point is at 188.66 °C. Dislocations and growth pattern present in the grown crystal revealed by the etching study. The mechanical strength of the CONS crystal has been studied by Vicker's hardness measurement. The SHG efficiency of the grown crystal has been determined by Kurtz and Perry powder test which revealed that the CONS crystal (327 mV) has 15 times greater efficiency than that of KDP (21.7 mV).

Dinakaran, Paul M.; Kalainathan, S.




Microsoft Academic Search

La selección recurrente para aptitud combinatoria en cultivos autógamos (SRAC), aunque exitosa, enfrenta dificultades para ha- cer las cruzas y para obtener suficiente semilla de éstas. Además, las derivaciones de la respuesta a la SRAC (R) basadas en el mode- lo de dos alelos pueden no ser adecuadas si la población se formó con más de dos progenitores. El objetivo

Jaime Sahagún-Castellanos; Autónoma Chapingo



An Exploratory Study of the W3C Mailing List Test Collection for Retrieval of Emails with Pro\\/Con Argument  

Microsoft Academic Search

The W3C mailing list test collection, an information re- trieval test collection for email, was developed for the TREC Enterprise Search track in 2005. One task in that track was to retrieve emails that contribute at least one pro\\/con related to a specific topic. This paper describes the test collection and presents a preliminary evaluation of its suit- ability for

Yejun Wu; Douglas W. Oard; Ian Soboroff



High mobility group box chromosomal protein 1 in acute-on-chronic liver failure patients and mice with ConA-induced acute liver injury.  


High mobility group box chromosomal protein 1 (HMGB1) is an important proinflammatory molecule in many inflammatory disorders, but little is known about its role in acute-on-chronic liver failure (ACLF). Here, we investigated the relationship between the expression of HMGB1 and the disease onset and severity of ACLF patients and mice with acute liver injury/failure induced by concanavalin A (ConA). Peripheral blood mononuclear cells (PBMCs) and serum from ACLF patients were collected, and a mouse model of acute liver injury/failure was induced by ConA. HMGB1 mRNA expression in patient PBMCs or in murine livers and serum HMGB1 protein in ACLF patients and mice were assayed by RT-PCR and Western blotting, respectively. HMGB1 translocation in hepatocytes of ConA-treated mice was assessed by immunohistochemical staining. Up-regulated HMGB1 mRNA levels in PBMCs and accumulated protein in serum were both correlated with disease severity in ACLF patients. In the animal model, HMGB1 levels increased at 4 h and reached its peak value at 8-12 h after challenge with ConA, which suggests that HMGB1 is a relatively late proinflammatory cytokine compared with TNF-?. Translocation of HMGB1 from the nucleus to the cytoplasm in hepatocytes was correlated with the severity of liver injury in mice. While specific anti-HMGB1 antibodies and nicotine protected mice from acute liver injury/failure by reducing mortality and improving liver tissue injury, treatment with recombinant HMGB1 led to an increased mortality due to ConA challenge. Thus, the data from the present study suggest that HMGB1 plays a critical role in the systemic inflammation of ACLF and could be a potential therapeutic target in the treatment of ACLF. PMID:22609241

Zhou, Rong-Rong; Liu, Hong-Bo; Peng, Jian-Ping; Huang, Yan; Li, Ning; Xiao, Mei-Fang; Wang, Haichao; Fan, Xue-Gong



Use of a GnRH vaccine, GonaCon, for prevention and treatment of adrenocortical disease (ACD) in domestic ferrets.  


Adrenocortical disease (ACD) is a common problem in surgically sterilized, middle-aged to old ferrets (Mustela putorius furo). The adrenal tissues of these ferrets develop hyperplasia, adenomas, or adenocarcinomas, which produce steroid hormones including estradiol, 17-hydroxyprogesterone, and androstenedione. Major clinical signs attributable to overproduction of these hormones are alopecia (hair loss) in both sexes and a swollen vulva in females. Pruritus, muscle atrophy, hind limb weakness, and sexual activity or aggression are also observed in both sexes. Males can develop prostatic cysts, prostatitis, and urethral obstruction. ACD is thought to be linked to continuous and increased LH secretion, due to lack of gonadal hormone feedback in neutered ferrets. This continuous elevated LH acts on adrenal cortex LH receptors, resulting in adrenal hyperplasia or adrenal tumor. This study investigated whether the immunocontraceptive vaccine GonaCon, a GnRH vaccine developed to reduce the fertility of wildlife species and the spread of disease, could prevent or delay onset of ACD and treat alopecia in ferrets with existing ACD. Results showed that GonaCon provided relief from ACD by causing production of antibodies to GnRH, probably suppressing production and/or release of LH. Treatment caused many ACD symptoms to disappear, allowing the ferrets to return to a normal life. The study also found that the probability of developing ACD was significantly reduced in ferrets treated with GonaCon when young (1-3 years old) compared to untreated control animals. GonaCon caused injection site reaction in some animals when administered as an intramuscular injection but caused few side effects when administered subcutaneously. Both intramuscular and subcutaneous vaccination resulted in similar levels of GnRH antibody titers. Subcutaneous vaccination with GonaCon is thus recommended to prevent the onset of ACD and as a possible treatment for ACD-signs in domestic ferrets. PMID:23906891

Miller, Lowell A; Fagerstone, Kathleen A; Wagner, Robert A; Finkler, Mark



Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor  

PubMed Central

We evaluated the expression of tissue factor (TF) in ovarian cancer (EOC) and the potential of hI-con1, an antibody-like molecule targeting TF, as a novel form of therapy against chemotherapy-resistant ovarian disease. We studied the expression of TF in 88 EOC by immunohistochemistry (IHC) and real-time-PCR (qRT-PCR) and the levels of membrane-bound-complement-regulatory-proteins CD46, CD55 and CD59 in primary EOC cell lines by flow-cytometry. Sensitivity to hI-con1-dependent-cell-mediated-cytotoxicity (IDCC), complement-dependent-cell-cytotoxicity and inhibition of IDCC by ?-immunoglobulin were evaluated in 5-h 51chromium-release-assays. Cytoplasmic and/or membrane TF expression was observed in 24 out of 25 (96%) of the EOC samples tested by IHC, but not in normal ovarian-tissue. EOC with clear cell histology significantly overexpress TF when compared to serous, endometrioid, or undifferentiated tumors by qRT-PCR. With a single exception, all primary EOC that overexpressed TF demonstrated high levels of CD46, CD55 and CD59 and regardless of their histology or resistance to chemotherapy, were highly sensitive to IDCC. The effect of complement and physiologic doses of ?-immunoglobulin on IDCC in ovarian cancer cell lines overexpressing TF was tumor specific and related to the overexpression of CD59 on tumor cells. Small-interfering-RNA-mediated knockdown of CD59 expression in ovarian tumors significantly increased hI-con1-mediated cytotoxic activity in vitro. Finally, low doses of interleukin-2 further increased the cytotoxic effect induced by hI-con1 (P < 0.01). hI-con1 molecule induces strong cytotoxicity against primary chemotherapy-resistant ovarian cancer cell lines overexpressing TF and may represent a novel therapeutic agent for the treatment of ovarian tumors refractory to standard treatment modalities.

Cocco, Emiliano; Varughese, Joyce; Buza, Natalia; Bellone, Stefania; Lin, Ken-Yu; Bellone, Marta; Todeschini, Paola; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E.; Rutherford, Thomas J.; Carrara, Luisa; Tassi, Renata; Pecorelli, Sergio; Lockwood, Charles J.



Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGF(c) chimeric protein targeting tissue factor.  


We evaluated the expression of tissue factor (TF) in ovarian cancer (EOC) and the potential of hI-con1, an antibody-like molecule targeting TF, as a novel form of therapy against chemotherapy-resistant ovarian disease. We studied the expression of TF in 88 EOC by immunohistochemistry (IHC) and real-time-PCR (qRT-PCR) and the levels of membrane-bound-complement-regulatory-proteins CD46, CD55 and CD59 in primary EOC cell lines by flow-cytometry. Sensitivity to hI-con1-dependent-cell-mediated-cytotoxicity (IDCC), complement-dependent-cell-cytotoxicity and inhibition of IDCC by ?-immunoglobulin were evaluated in 5-h (51)chromium-release-assays. Cytoplasmic and/or membrane TF expression was observed in 24 out of 25 (96%) of the EOC samples tested by IHC, but not in normal ovarian-tissue. EOC with clear cell histology significantly overexpress TF when compared to serous, endometrioid, or undifferentiated tumors by qRT-PCR. With a single exception, all primary EOC that overexpressed TF demonstrated high levels of CD46, CD55 and CD59 and regardless of their histology or resistance to chemotherapy, were highly sensitive to IDCC. The effect of complement and physiologic doses of ?-immunoglobulin on IDCC in ovarian cancer cell lines overexpressing TF was tumor specific and related to the overexpression of CD59 on tumor cells. Small-interfering-RNA-mediated knockdown of CD59 expression in ovarian tumors significantly increased hI-con1-mediated cytotoxic activity in vitro. Finally, low doses of interleukin-2 further increased the cytotoxic effect induced by hI-con1 (P < 0.01). hI-con1 molecule induces strong cytotoxicity against primary chemotherapy-resistant ovarian cancer cell lines overexpressing TF and may represent a novel therapeutic agent for the treatment of ovarian tumors refractory to standard treatment modalities. PMID:21725665

Cocco, Emiliano; Varughese, Joyce; Buza, Natalia; Bellone, Stefania; Lin, Ken-Yu; Bellone, Marta; Todeschini, Paola; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E; Rutherford, Thomas J; Carrara, Luisa; Tassi, Renata; Pecorelli, Sergio; Lockwood, Charles J; Santin, Alessandro D



Virgin Caenorhabditis remanei females are attracted to a coital pheromone released by con-specific copulating males  

PubMed Central

The gonochoristic soil nematode Caenorhabditis remanei strictly requires copulation for species propagation. Males of this species are sexually promiscuous with females of other species; therefore, we asked in this study whether virgin C. remanei females display evidence of mate choice. We digitally recorded and measured the locomotor behaviors of one or more virgin females in the presence of a single male on a 5 mm diameter mating lawn. We observed that initially only the male modifies his locomotor trajectory to another animal on the mating lawn; the virgin females showed no locomotor bias toward the mate-searching male. However, once a male started to copulate, females in the vicinity altered their movement trajectories toward the copulating couple. Newly inseminated females are refractive to the coital signal, but partially regain their attraction to copulating males after 24 h. We found only copulating males with an intact gonad can attract females, and that the coital signal can be broadcasted at least 1.5 mm through the air. Unlike males, which are also attracted to hetero-specific females, virgin C. remanei females will only crawl toward a copulating con-specific male. We suggest that Caenorhabditis females use the coital signal as a pheromone to identify a vigorous male of their own species.

Markert, Mathew; Garcia, Luis Rene



Document-level classification of CT pulmonary angiography reports based on an extension of the ConText algorithm.  


In this paper we describe an application called peFinder for document-level classification of CT pulmonary angiography reports. peFinder is based on a generalized version of the ConText algorithm, a simple text processing algorithm for identifying features in clinical report documents. peFinder was used to answer questions about the disease state (pulmonary emboli present or absent), the certainty state of the diagnosis (uncertainty present or absent), the temporal state of an identified pulmonary embolus (acute or chronic), and the technical quality state of the exam (diagnostic or not diagnostic). Gold standard answers for each question were determined from the consensus classifications of three human annotators. peFinder results were compared to naive Bayes' classifiers using unigrams and bigrams. The sensitivities (and positive predictive values) for peFinder were 0.98(0.83), 0.86(0.96), 0.94(0.93), and 0.60(0.90) for disease state, quality state, certainty state, and temporal state respectively, compared to 0.68(0.77), 0.67(0.87), 0.62(0.82), and 0.04(0.25) for the naive Bayes' classifier using unigrams, and 0.75(0.79), 0.52(0.69), 0.59(0.84), and 0.04(0.25) for the naive Bayes' classifier using bigrams. PMID:21459155

Chapman, Brian E; Lee, Sean; Kang, Hyunseok Peter; Chapman, Wendy W



Status and Progress of a Fault Current Limiting Hts Cable to BE Installed in the con EDISON Grid  

NASA Astrophysics Data System (ADS)

In the last decade, significant advances in the performance of second generation (2G) high temperature superconducting wire have made it suitable for commercially viable applications such as electric power cables and fault current limiters. Currently, the U.S. Department of Homeland Security is co-funding the design, development and demonstration of an inherently fault current limiting HTS cable under the Hydra project with American Superconductor and Consolidated Edison. The cable will be approximately 300 m long and is being designed to carry 96 MVA at a distribution level voltage of 13.8 kV. The underground cable will be installed and energized in New York City. The project is led by American Superconductor teamed with Con Edison, Ultera (Southwire and nkt cables joint venture), and Air Liquide. This paper describes the general goals, design criteria, status and progress of the project. Fault current limiting has already been demonstrated in 3 m prototype cables, and test results on a 25 m three-phase cable will be presented. An overview of the concept of a fault current limiting cable and the system advantages of this unique type of cable will be described.

Maguire, J.; Folts, D.; Yuan, J.; Henderson, N.; Lindsay, D.; Knoll, D.; Rey, C.; Duckworth, R.; Gouge, M.; Wolff, Z.; Kurtz, S.



Virgin Caenorhabditis remanei females are attracted to a coital pheromone released by con-specific copulating males.  


The gonochoristic soil nematode Caenorhabditis remanei strictly requires copulation for species propagation. Males of this species are sexually promiscuous with females of other species; therefore, we asked in this study whether virgin C. remanei females display evidence of mate choice. We digitally recorded and measured the locomotor behaviors of one or more virgin females in the presence of a single male on a 5 mm diameter mating lawn. We observed that initially only the male modifies his locomotor trajectory to another animal on the mating lawn; the virgin females showed no locomotor bias toward the mate-searching male. However, once a male started to copulate, females in the vicinity altered their movement trajectories toward the copulating couple. Newly inseminated females are refractive to the coital signal, but partially regain their attraction to copulating males after 24 h. We found only copulating males with an intact gonad can attract females, and that the coital signal can be broadcasted at least 1.5 mm through the air. Unlike males, which are also attracted to hetero-specific females, virgin C. remanei females will only crawl toward a copulating con-specific male. We suggest that Caenorhabditis females use the coital signal as a pheromone to identify a vigorous male of their own species. PMID:24058874

Markert, Mathew; García, Luis René



Pro/con clinical debate: The use of prone positioning in the management of patients with acute respiratory distress syndrome  

PubMed Central

Critical care medicine is a relatively new specialty and as such there is not a great deal of accumulated data to allow clinicians to practice 'evidence-based medicine' in all situations they encounter. When evidence does exist, intensivists may choose not to follow it based on 'gut feelings' or their own interpretation of how the data apply to their patient. It is perhaps not surprising that these latter events occur given that intensivists are often literally fighting for their patient's lives. Prone positioning evokes a large emotional response from many intensivists. Despite accumulating data there appears to be two camps of clinicians: those who strongly believe in the therapy, and those who want more data. The emotion and rationale for the mindset of the two camps is evident in this issue of Critical Care Forum. With compelling arguments on both sides of the fence, it is apparent that this debate is far from over. The authors of this pro/con debate, which is based on a clinical scenario, first describe their position and then respond to their opponent's position.

Marini, John J; Rubenfeld, Gordon



Laboratory simulation of Kuiper belt object volatile ices under ionizing radiation: CO-N2 ices as a case study.  


The exposure of icy Kuiper belt objects (KBOs) by ionizing radiation was simulated in this case of exposing carbon monoxide-nitrogen (CO-N(2)) ices by energetic electrons. The radiation-induced chemical processing was monitored on-line and in situ via FTIR spectroscopy and quadrupole mass spectrometry. Besides the array of carbon oxides being reproduced as in neat irradiated carbon monoxide (CO) ices studied previously, the radiation exposure at 10 K resulted in the formation of nitrogen-bearing species of isocyanato radical (OCN), linear (l-NCN), nitric oxide (NO), nitrogen dioxide (NO(2)), plus diazirinone (N(2)CO). The infrared assignments of these species were further confirmed by isotopic shifts. The temporal evolution of individual species was found to fit in first-order reaction schemes, prepping up the underlying non-equilibrium chemistry on the formation of OCN, l-NCN, and NO radicals in particular. Also unique to the binary KBO model ices and viable for the future remote detection is diazirinone (N(2)CO) at 1860 cm(-1) (2?(5)) formed at lower radiation exposure. PMID:21687881

Kim, Y S; Zhang, F; Kaiser, R I



Trattamento ortopedico con corsetto  

Microsoft Academic Search

\\u000a Abstract  Conservative treatment of scoliosis by orthopaedic brace has an indication in cases of moderate or mild scoliosis. Its efficacy\\u000a is demonstrated through the experience of several orthopaedic schools. The indication to adopt an orthopaedic brace is given\\u000a by: curve degrees and its correggibility, skeletal age of patients and cosmetical aspect. The choice of the appropriate brace\\u000a depends on kind and

D. Peroni; F. Spreafico; W. Albisetti



urban ConAgraculture  

Microsoft Academic Search

Current pressures in today’s world caused me to investigate strategies of change in the organization of society to promote a more effi cient existence. Globalization, a movement characterized by the dissemination of economies, ethnicities, media, ideas, technologies, and production; has become today’s reality. The shift from imperialism to globalism has caused a decline in the power and importance of nation

Dale J Luebbert



The Protective Effect of Intrasplenic Transplantation of Ad-IL-18BP/IL-4 Gene-Modified Fetal Hepatocytes on ConA-Induced Hepatitis in Mice  

PubMed Central

Background Concanavalin A (ConA)-induced hepatitis is an experimental murine model mirroring the pathology of human autoimmune hepatitis. Aim To investigate the effects of intrasplenically transplanted fetal hepatocytes (BNL.CL2) transfected with recombinant adenovirus vector expressing the IL-18 binding protein (IL-18BP) and IL-4 fusion protein on ConA-induced hepatitis in mice. Methods Ad-IL-18BP/IL-4 was used to infect BNL.CL2 cells. IL-4 and IL-18BP fusion protein expression were detected by ELISA and Western blotting. BNL.CL2 cells infected with Ad-IL-18BP/IL-4 were intrasplenically transplanted into mice. After 10 days, mice were injected with ConA (15 mg/kg), and sacrificed 18 hours later. Liver injury was assessed by serum transaminase and liver histology. TNF-?, IL-18, IL-4, IL-10, IL-12p70 and monocyte-chemoattracting protein (MCP)-1 levels in serum and liver homogenates were detected by ELISA. Signaling molecules in liver homogenates were analyzed by Western blotting. Results Ad-IL-18BP/IL-4 effectively expressed the IL-18BP/IL-4 fusion protein for more than 14 days in BNL.CL12 cells. Treatment of mice with Ad-IL-18BP/IL-4-BNL.CL2 before ConA injection significantly reduced the elevated plasma levels of transaminases compared with ConA control groups. TNF-?, IL-18, IL-12p70 and MCP-1 levels in serum and liver homogenates from mice transplanted with Ad-IL-18BP/IL-4-BNL.CL2 were lower and IL-4 and IL-10 levels were higher than control groups. Phosphorylation levels of NF-?B p65, AKT, p38 and JNK1/2 in liver homogenates were markedly suppressed by Ad-IL-18BP/IL-4. Conclusions Ad-IL-18BP/IL-4 was effectively transfected into mouse BNL.CL2 cells. Intrasplenic transplantation of Ad-IL-18BP/IL-4-BNL.CL12 cells alleviated the severity of inflammation in ConA-induced experimental hepatitis and provides a useful basis for the targeted gene therapy of liver disease.

Xu, Chenhuai; Hong, Bo; Xu, Wanhong; Shen, Ling; Jin, Changzhong; Wu, Zhigang; Tong, Xiangmin; Yao, Hangping



Long-term fertility control in female cats with GonaCon™, a GnRH immunocontraceptive.  


The uncontrolled reproduction of free-roaming feral cats contributes to overpopulation and associated concerns regarding their welfare and impact on public health and the environment. Nonsurgical fertility control that could be administered to feral cats in the field would be a powerful tool for cat population control. The objective was to test the efficacy and duration of activity of a single-dose GnRH immunocontraceptive vaccine (GonaCon™) on the fertility of adult female laboratory cats. Vaccinated cats (n = 15) received a single injection of vaccine containing a GnRH-KLH conjugate (200 ?g) emulsified in a mycobacterial and oil adjuvant on study Day 0. Sham-treated cats (n = 5) received a single injection containing all vaccine components except the GnRH-KLH conjugate. A breeding trial started on study Day 120. Vaccinated cats had a longer time to conception (median 39.7 mo) compared to sham-treated cats (4.4 mo; P < 0.001). A total of 93% of vaccinated cats remained infertile for the first year following vaccination, whereas 73, 53, and 40% were infertile for 2, 3, and 4 y, respectively. At study termination (5 y after a single GnRH vaccine was administered), four cats (27%) remained infertile. The GnRH antibody titers declined more rapidly in short-term responding cats with < 2 y of infertility (n = 4), compared to long-term responding cats that experienced fertility control for >2 y (n = 11) (P < 0.05). Non-painful but persistent late-onset granulomatous injection site masses appeared 2 y after initial vaccination in five cats. We concluded that GnRH immunocontraception is an ideal candidate for further development for feral cat control. PMID:21835455

Levy, Julie K; Friary, John A; Miller, Lowell A; Tucker, Sylvia J; Fagerstone, Kathleen A



Preliminary experience with a 'sub-50' combined oral contraceptive, containing 35 micrograms ethinyl oestradiol and 1 mg norethisterone ('NeoCon').  


The present trend in oral contraception is clearly in favour of the 'sub-50' pills, taking into consideration the recent publications on the association between cardiovascular affections and pill intake. 'NeoCon', a combination pill containing 1 mg norethisterone and 35 micrograms ethinyl oestradiol, has been investigated in the United States, Mexico, Germany, Belgium and the United Kingdom. From all these studies, it could be concluded that it is an effective and well-tolerated oral contraceptive. From the present series, totalling 104 patients with 1232 cycles, first clinical impressions confirm the evaluations of other investigators: no pregnancies, only mild cycle disturbances disappearing after a few adaptation cycles, few side-effects and excellent tolerance. Due to the low potency and the low contents of its components, it is suggested that 'NeoCon' is appropriate for all women in general and for the younger women in particular. PMID:7433480

Schellen, A M



Canadian Shield brine from the Con Mine, Yellowknife, NT, Canada: Noble gas evidence for an evaporated Palaeozoic seawater origin mixed with glacial meltwater and Holocene recharge  

Microsoft Academic Search

Dissolved noble gas concentrations were measured in high salinity (270g\\/L) Ca(Na)-Cl groundwaters from the Con Mine, Yellowknife, Canada in an effort to discriminate between two possible origins, as either a brine generated by evaporative enrichment in a Paleozoic inland sea, or marine water concentrated by freezing during glacial times. Major ion and isotope geochemistry indicate that brines from the deepest

Shane Greene; Nick Battye; Ian Clark; Tom Kotzer; Dennis Bottomley



An appraisal of a column-generation-based algorithm for a centralized train-con?ict resolution on metropolitan railway network  

Microsoft Academic Search

In practice, a train-con?ict resolution is decentralized around the dispatchers each of whom, with her rule-of-thumb to operational data, controls a few segments from a global railway network. Conceptually, a global sub-optimality or infeasibility of the decentralized system is resolved by a network controller on the top of the lower layers of the dispatchers and the drivers operating trains on

Sung-Pil Hong; Yun-Hong Min; Soon-Heum Hong


Dissection of the Intracellular Pathways in Hepatocytes Suggests a Role for Jun Kinase and IFN Regulatory Factor1 in Con A-Induced Liver Failure1  

Microsoft Academic Search

Con A administration results in dose-dependent immune-mediated liver injury. Cytokines are important to determine the outcome of liver failure in this model, and especially TNF-a and IFN-g directly contribute to hepatocyte damage. The intracellular pathways of these two cytokines, which eventually result in tissue destruction, are not well defined. Here we used anti-IFN-g Abs and adenoviral vectors that express molecules

Konrad Streetz; Bastian Fregien; Jorg Plumpe; Kerstin Korber; Stefan Kubicka; Stephan C. Bischoff; Michael P. Manns; Gisa Tiegs; Christian Trautwein


A review of the practice of sedation with inhalational anaesthetics in the intensive care unit with the AnaConDa(®) device.  


The intensive care unit (ICU) environment is often perceived to be hostile and frightening by patients due to unfamiliar surroundings coupled with presence of numerous personnel, monitors and other equipments as well as a loss of perception of time. Mechanical ventilation and multiple painful procedures that often need to be carried out in these critically ill patients add to their overall anxiety. Sedation is therefore required not only to allay the stress and anxiety, but also to allow for mechanical ventilation and other invasive therapeutic and diagnostic procedures to be performed. The conventional intravenous sedative agents used in ICUs suffer from problems of over sedation, tachyphylaxis, drug accumulation, organ specific elimination and often lead to patient agitation on withdrawal. All this tend to prolong the ventilatory as well as ICU and hospital discharge time, which increase the risk for infection and add to the overall increase in morbidity, mortality and hospital costs. In 2005, the anaesthetic conserving device (AnaConDa(®)) was marketed for ICU sedation with volatile anaesthetic agents. A number of trials have shown the effectiveness of using volatile anaesthetic agents for ICU sedation with the AnaConDa device. Compared with intravenous sedatives, use of volatile anaesthetic agents have resulted in shorter wake up and extubation time, lesser duration of mechanical ventilation and faster discharge from hospitals. This review shall focus on the benefits, technical pre-requisites and status of sedation with volatile anaesthetic agents in ICUs with the AnaConDa(®) device. PMID:23325934

Misra, Satyajeet; Koshy, Thomas



Pro/Con Forum: The MACOS Controversy. The Push for a Uniform National Curriculum [And] MACOS Revisited: A Commentary on the Most Frequently Asked Questions about "Man: A Course of Study"  

ERIC Educational Resources Information Center

|The pro/con forum presents opposing viewpoints on the controversial MACOS curriculum (Educational Development Corporation) by Peter Dow, Director of EDC and Congressman John B. Conlan, Arizona. (JR)|

Conlan, John B.; Dow, Peter B.



Theoretical Study of Magnetic Properties of VN, CrN, MnN, FeN and CoN under strain  

NASA Astrophysics Data System (ADS)

We present an ab initio tooled study on magnetic and electronic properties of 3d transition metals mononitrides under hydrostatic and biaxial strain, in wurtzite (w) and zincblende (zb) structure, and find all of them to become half-metallic (HM) under lattice expansion in the zb structure. The first compound to become HM under lattice expansion is MnN, followed by CrN, VN, FeN and CoN, with integer magnetic moments of 4, 3, 2, 5 and 6 ?B, respectively. We investigate the possibility of MBE growing of zb-CrN on cubic GaN.

Ribeiro, M.; Marques, M.; Scolfaro, L. M. R.; Teles, L. K.; Ferreira, L. G.



Estudio de la fotoabsorción y fotoionización de la molécula de alta relevancia atmosférica no a través de los estados Rydberg con la metodología MQDO  

NASA Astrophysics Data System (ADS)

Los procesos de fotoionización son de una importancia fundamental [1] y encuentran aplicación en un gran número de contextos científicos: Astrofísica [2], química de las radiaciones, biología. Los investigadores de dichos campos, necesitan de valores de fiables de secciones eficaces para la fotoionización parcial, la Fotoabsorción, así como para los procesos de fotofragmentación en amplios intervalos espectrales, particularmente en estudios de modelización [3-5]. En este trabajo se ha centrado la atención sobre el oxido nítrico, que se ha considerado apropiado y relevante por varios motivos: por el trascendental papel que representa en la física y química de la alta atmosfera [6], aparte de por estar íntimamente relacionado con los problemas de contaminación. Los procesos de recombinación disociativa [7] del NO, donde los estados Rydberg se encuentran directamente implicados, son relevantes, por ejemplo, en las regiones E y F de la ionosfera [7]. En este trabajo se estudia la fotoionización del NO desde el estado fundamental con la versión molecular del método del orbital de defecto cuántico (MQDO). Para ello se calcula el diferencial de las fuerzas de oscilador parciales que constituyen los canales de fotoionización del NO desde el estado fundamental. La continuidad del diferencial de fuerza de oscilador calculada a través del umbral de fotoionización, esto es, en las regiones del espectro discreta y del continua, se adopta como criterio de calidad la escasez de datos comparativos [8].

Bustos, E.; Velasco, A. M.; Martín, I.; Lavín, C.


Induction of Macrophage Migration Inhibitory Factor in ConA-Stimulated Rheumatoid Arthritis Synovial Fibroblasts through the P38 MAP Kinase-Dependent Signaling Pathway  

PubMed Central

Background/Aims This study was undertaken to identify the intracellular signaling pathway involved in induction of macrophage migration inhibitory factor (MIF) in human rheumatoid arthritis (RA) synovial fibroblasts. Methods Human RA synovial fibroblasts were treated with concanavalin A (ConA), various cytokines, and inhibitors of signal transduction molecules. The production of MIF by synovial fibroblasts was measured in culture supernatants by ELISA. The expression of MIF mRNA was determined using reverse transcriptase polymerase chain reaction (RT-PCR) and real-time PCR. Phosphorylation of p38 mitogen-activated protein (MAP) kinase in synovial fibroblasts was confirmed using Western blotting. The expression of MIF and p38 MAP kinase in RA synovium was determined using dual immunohistochemistry. Results The production of MIF by RA synovial fibroblasts increased in a dose-dependent manner after ConA stimulation. MIF was also induced by interferon-?, CD40 ligand, interleukin-15, interleukin-1?, tumor necrosis factor-?, and transforming growth factor-?. The production of MIF by RA synovial fibroblasts was significantly reduced after inhibition of p38 MAP kinase. The expression of MIF and p38 MAP kinase was upregulated in the RA synovium compared with the osteoarthritis synovium. Conclusions These results suggest that MIF production was induced through a p38 MAP-kinase-dependent pathway in RA synovial fibroblasts.

Kim, Hae-Rim; Park, Mi-Kyung; Kim, Kyoung-Woon; Oh, Hye-Joa; Park, Jin-Sil; Heo, Yang-Mi; Lee, Sang-Heon; Kim, Ho-Youn



The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment  

PubMed Central

For more than half a decade, lithium has been successfully used to treat bipolar disorder. Worldwide, it is considered the first-line mood stabilizer. Apart from its proven antimanic and prophylactic effects, considerable evidence also suggests an antisuicidal effect in affective disorders. Lithium is also effectively used to augment antidepressant drugs in the treatment of refractory major depressive episodes and prevent relapses in recurrent unipolar depression. In contrast to many psychiatric drugs, lithium has outlasted various pharmacotherapeutic ‘fashions’, and remains an indispensable element in contemporary psychopharmacology. Nevertheless, data from pharmacogenetic studies of lithium are comparatively sparse, and these studies are generally characterized by small sample sizes and varying definitions of response. Here, we present an international effort to elucidate the genetic underpinnings of lithium response in bipolar disorder. Following an initiative by the International Group for the Study of Lithium-Treated Patients ( and the Unit on the Genetic Basis of Mood and Anxiety Disorders at the National Institute of Mental Health, lithium researchers from around the world have formed the Consortium on Lithium Genetics ( to establish the largest sample to date for genome-wide studies of lithium response in bipolar disorder, currently comprising more than 1,200 patients characterized for response to lithium treatment. A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts.

Schulze, Thomas G.; Alda, Martin; Adli, Mazda; Akula, Nirmala; Ardau, Raffaella; Bui, Elise T.; Chillotti, Caterina; Cichon, Sven; Czerski, Piotr; Del Zompo, Maria; Detera-Wadleigh, Sevilla D.; Grof, Paul; Gruber, Oliver; Hashimoto, Ryota; Hauser, Joanna; Hoban, Rebecca; Iwata, Nakao; Kassem, Layla; Kato, Tadafumi; Kittel-Schneider, Sarah; Kliwicki, Sebastian; Kelsoe, John R.; Kusumi, Ichiro; Laje, Gonzalo; Leckband, Susan G.; Manchia, Mirko; MacQueen, Glenda; Masui, Takuya; Ozaki, Norio; Perlis, Roy H.; Pfennig, Andrea; Piccardi, Paola; Richardson, Sara; Rouleau, Guy; Reif, Andreas; Rybakowski, Janusz K.; Sasse, Johanna; Schumacher, Johannes; Severino, Giovanni; Smoller, Jordan W.; Squassina, Alessio; Turecki, Gustavo; Young, L. Trevor; Yoshikawa, Takeo; Bauer, Michael; McMahon, Francis J.



A wireless, remote-query and high sensitivity Escherichia coli O157: H7 biosensor based on the recognition action of Con A  

PubMed Central

Escherichia coli O157: H7 is detected using a remote-query (wireless, passive) magnetoelastic sensor platform to which a 1 µm-thick layer of Bayhydrol 110 and then a layer of functionalized mannose is applied. The multivalent binding of lectin concanavalin A (Con A) to the E. coli surface O-antigen and mannose favors the strong adhesion of E. coli to the mannose modified magnetoelastic sensor; E. coli is rigidly and strongly attached on the mannose-modified sensor through Con A, which works as a bridge to bind to the E. coli surface O-antigen and mannose modified sensor surface. As E. coli is bound to the sensor its resonance frequency shifts, enabling quantification of E. coli concentration with a limit of detection of 60 cells/mL and a linear logarithmic response range of 6.0×101 to 6.1×109 cells/mL. The analysis can be directly conducted without incubation, and completed in 3 h or less.

Lu, Qingzhu; Lin, Hailan; Ge, Shutian; Luo, Shenglian; Cai, Qingyun; Grimes, Craig A.



The Effect of Coadsorbed Water on the Stability, Con?guration and Interconversion of Formyl (HCO) and Hydroxymethylidyne (COH) on Platinum (1 1 1)  

SciTech Connect

Two forms of the methanol electro-oxidation intermediate with stoichiometry C:H:O, COH (hydroxymethylidyne) and HCO (formyl), on Pt (11 1) with and without coadsorbed water were studied using density functional theory calculations. The structure, adsorption energy and stability with respect to dissociation were calculated. Both HC=O and C–OH were stable on clean Pt (11 1) and with a single coadsorbed water molecule, while only the HCO con?guration was stable in the presence of a whole water layer. The vibrational modes of HC=O on a bridge site showed no mode around 1700 cm-1 characteristic of C=O stretch making it hard to distinguish it from C–OH.

Arnadottir, Liney; Stuve, Eric M.; Jonsson, Hannes



Broadening, shifting, and line asymmetries in the 2<--0 band of CO and CO-N2: Experimental results and theoretical calculations  

NASA Astrophysics Data System (ADS)

We have measured the room temperature, widths, pressure shifts, and line asymmetry coefficients for many transitions of the first overtone band of CO and CO perturbed by N2. The broadening coefficients were obtained with an accuracy of about 1%. The pure CO profiles have been fitted by a Voigt profile while the CO-N2 spectral profiles have been fitted with a Lorentz and an empirical line shape model (HCv) that blends together a hard collision model and a speed-dependent Lorentz profile. In addition to the Voigt, Lorentz, and HCv models, we have added a dispersion profile to account for weak line mixing. The line broadening and shift coefficients are compared to semiclassical calculations employing a variety of intermolecular interactions. The line asymmetry results are compared to line mixing calculations based on the energy corrected sudden (ECS) model. The results indicate that effects other than line mixing also contribute to the measured line asymmetry.

Predoi-Cross, Adriana; Bouanich, J. P.; Benner, D. Chris; May, A. D.; Drummond, J. R.



Hydrogen adsorption and magnetic behavior of Fen and Con clusters: Controlling the magnetic moment and anisotropy one atom at a time  

NASA Astrophysics Data System (ADS)

Theoretical studies to investigate the effect of H absorption on the magnetic moment of small Fen and Con clusters have been carried out using gradient corrected density-functional approach. Our studies on clusters containing up to four transition metal and 2 H atoms show that the successive addition of H atoms can lead to monotonic or oscillatory change from the free cluster magnetic moment. A detailed analysis of the density of electronic states shows that the variations in the magnetic moment can be related to the location of the lowest unoccupied molecular orbital in the parent cluster. It is shown that the addition of hydrogen can substantially change the magnetic anisotropy. In particular Co3H2 is shown to exhibit magnetic anisotropy that is higher than any of the known anisotropies in the molecular nanomagnets.

Jones, N. O.; Beltran, M. R.; Khanna, S. N.; Baruah, T.; Pederson, M. R.



Intracellular free zinc up-regulates IFN-? and T-bet essential for Th1 differentiation in Con-A stimulated HUT-78 cells  

PubMed Central

Zinc deficiency impairs cellular immunity. Up-regulation of mRNA levels of IFN-?, IL-12R?2, and T-bet are essential for Th1 differentiation. We hypothesized that zinc increases Th1 differentiation via up-regulation of IFN-? and T-bet expression. To test this hypothesis, we used zinc-deficient and zinc-sufficient HUT-78 cells (a Th0 cell line) under different condition of stimulation in this study. We also used TPEN, a zinc-specific chelator, to decrease the bioavailability of zinc in the cells. We measured intracellular free zinc, cytokines, and the mRNAs of T-bet, IFN-?, and IL-12R?2. In this study, we show that in zinc-sufficient HUT-78 cells (a Th0 cell line), mRNA levels of IFN-?, IL-12R?2, and T-bet in PMA/PHA-stimulated cells were increased in comparison to zinc-deficient cells. Although intracellular free zinc was increased slightly in PMA/PHA-stimulated cells, Con-A-stimulated cells in 5 ?M zinc medium showed a greater sustained increase in intracellular free zinc in comparison to cells incubated in 1 ?M zinc. The cells pre-incubated with TPEN showed decreased mRNA levels of IFN-? and T-bet mRNAs in comparison to cells without TPEN incubation. We conclude that stimulation of cells by Con-A via TCR, release intracellular free zinc which functions as a signal molecule for generation of IFN-? and T-bet, and IL-12Rb?2 mRNAs required for Th1 cell differentiation. These results suggest that zinc increase Th1 cell differentiation by up-regulation of IFN-? and T-bet, and IL-12Rb?2 mRNAs.

Bao, Bin; Prasad, Ananda S.; Beck, Frances WJ; Bao, Ginny W.; Singh, Tapinder; Ali, Shadan; Sarkar, Fazlul H.



Actitudes de madres adolescentes y adultas y su relación con la personalidad de sus hijos Attitudes of adolescent and adult mothers and their relation with their children's personality profile  

Microsoft Academic Search

La presente investigación tuvo el propósito de indagar si hay diferencias entre las actitudes de las madres adolescentes y adultas e identificar si existe una relación entre las actitudes de las madres y el perfil de personalidad de sus hijos. Participaron 35 mujeres con sus hijos, quienes cursaban el primer grado de primaria; 17 fueron madres siendo adolescentes y 18

Iris Xóchitl; Galicia Moyeda; Lucina Jiménez Vega; Susana Pavón Figueroa; Alejandra Sánchez Velasco



Liberación\\/mineralización de nitrógeno en hojarasca de Eucalyptus grandis y leguminosas herbáceas, su relación con la calidad física y química del residuo y su efecto sobre el crecimiento de plantas jóvenes de eucalipto  

Microsoft Academic Search

Resumen El tipo de cosecha y manejo de residuos inciden en el contenido de nutrientes del suelo y la productividad forestal. Estos residuos contienen la mayoría del retorno de N. La velocidad de provisión de nutrientes por la descomposición\\/mineralización puede verse afectada por la calidad química y física como por la localización y contacto de los residuos con el suelo.

Alcaraz Maria Luciana



Microsoft Academic Search

Knowledge about model uncertainty is essential for crop modelling and provides information crucial for a real understand- ing of models behavior and for parameterization purposes. This work addresses an exploratory sensitivity analysis on the parameters involved with biomass accumulation of three crop models decidedly differing in the way they interpret the con- cept of growth. The models used in the

Roberto Confalonieri; Marco Acutis; Gianni Bellocchi; Iacopo Cerrani; Stefano Tarantola; Marcello Donatelli; Giampiero Genovese


Monitoreo de ecosistemas con estrategias geoestadísticas, una aplicación de gran escala en Jalisco, México Ecosystem monitoring through the use of geostatistic strategies, a large scale application in Jalisco, Mexico  

Microsoft Academic Search

RESUMEN El proyecto de Inventario y Monitoreo de los Recursos Naturales de Jalisco, México (IMRENAT), es un proceso innovador que propone una aplicación práctica de las herramientas de modelado esta- dístico geoespacial para reportar creíblemente la condición del territorio. Aprovechando las intercone- xiones que existen entre atributos del terreno, la vegetación, las actividades humanas y lo detectable con sensores remotos

José Germán Flores Garnica; Martín Alfonso; Celedonio Aguirre Bravo


Eficacia del tratamiento con leflunomida en pacientes con artritis psoriásica  

Microsoft Academic Search

Psoriatic arthritis (PsA) occurs in 1-3% of the population and 25% of affected patients require systemic therapy. The drugs used in PsA have been developed for other diseases, mainly rheumatoid arthritis (RA), and there are no clinical trials supporting their efficacy and safety in these patients. Leflunomide (LFN) inhibits the activation and proliferation of T-lymphocytes and is considered to be

Ingrid Möller



A novel mammalian myosin I from rat with an SH3 domain localizes to Con A-inducible, F-actin-rich structures at cell-cell contacts  

PubMed Central

In an effort to determine diversity and function of mammalian myosin I molecules, we report here the cloning and characterization of myr 3 (third unconventional myosin from rat), a novel mammalian myosin I from rat tissues that is related to myosin I molecules from protozoa. Like the protozoan myosin I molecules, myr 3 consists of a myosin head domain, a single light chain binding motif, and a tail region that includes a COOH-terminal SH3 domain. However, myr 3 lacks the regulatory phosphorylation site present in the head domain of protozoan myosin I molecules. Evidence was obtained that the COOH terminus of the tail domain is involved in regulating F-actin binding activity of the NH2-terminal head domain. The light chain of myr 3 was identified as the Ca(2+)-binding protein calmodulin. Northern blot and immunoblot analyses revealed that myr 3 is expressed in many tissues and cell lines. Immunofluorescence studies with anti-myr 3 antibodies in NRK cells demonstrated that myr 3 is localized in the cytoplasm and in elongated structures at regions of cell-cell contact. These elongated structures contained F-actin and alpha-actinin but were devoid of vinculin. Incubation of NRK cells with Con A stimulated the formation of myr 3-containing structures along cell-cell contacts. These results suggest for myr 3 a function mediated by cell-cell contact.



Observations on the effects of inhaled isoflurane in long-term sedation of critically Ill children using a modified AnaConDa©-system.  


Long-term intravenous sedation may present problems due to dependence and side effects. Medical records of children who were administered isoflurane were reviewed. 15 patients (9 boys, 6 girls) with a mean age of 11.8 month (+2.4) were analysed.Analgesia and sedation was given in mean 9.7+1.1 days before commencing inhalation using a modified application device (AnaConDa©). Administration was given over a period of 7.2+1.4 days. Depth of sedation was monitored by using Comfort- and Hartwig-scores. Observations included continuous monitoring of heart-rate, pulse oxymetry, blood pressure and cerebral tissue oxygenation.Within 4 h post administration of isoflurane a satisfactory increase in the depth of sedation was seen and kept till extubation. 6/15 patients received tracheostomies during the observation period. None of the patients observed suffered life-critical events of the modified application of isoflurane proceeded without complications. Ketamine and clonidine infusion rates were significantly reduced (p<0.005) as well as the use and overall infusion rate of midazolam, ?-hydroxy butyrate, fentanyl and morphine (p<0.05).Isoflurane inhalation may provide an additional option for long-term sedation in a specific group of critically ill infants but neurodegenerative toxic effects will have to be taken into account when using volatile anesthetics at any time during infancy. PMID:23797368

Eifinger, F; Hünseler, C; Roth, B; Vierzig, A; Oberthuer, A; Mehler, K; Kribs, A; Menzel, C; Trieschmann, U



Biochar Usage: Pros and Cons  

Technology Transfer Automated Retrieval System (TEKTRAN)

Soil fertility benefits of charcoal application have been reported as early as 1847 indicating that plant nutrients are sorbed within charcoal pores. The use of biomass-derived black carbon or biochar, the solid byproduct from the pyrolysis processing of any organic feedstock, has garnered recent a...


Quality of life and psycho-social development in children with otitis media with effusion Qualità di vita e sviluppo psico-sociale nei bambini con otite media secretiva  

Microsoft Academic Search

th class, mostly due to persistent attention disturbances. In the State-Trait Anxiety Inventory test, 50% of parents or care- givers had a high state-anxiety score and so were mostly con- cerned with health status of the children. The State-Trait Anx- iety Inventory results indicated that 50% of parents or care- givers had a high trait-anxiety score and thus had an



Comparison between dynamic cystocolpoproctography and dynamic pelvic floor MRI: pros and cons: Which is the "functional" examination for anorectal and pelvic floor dysfunction?  


"Functional" imaging of anorectal and pelvic floor dysfunction has assumed an important role in the diagnosis and management of these disorders. Although defecography has been widely practiced for decades to evaluate the dynamics of rectal emptying, debate concerning its clinical relevance, how it should be done and interpreted continues. Due to the recognition of the association of defecatory disorders with pelvic organ prolapse in women, the need to evaluate the pelvic floor as a unit has arisen. To meet this need, defecography has been extended to include not only evaluation of defecation disorders but also the rest of the pelvic floor by opacifying the small bowel, vagina, and the urinary bladder. The term "dynamic cystocolpoproctography" (DCP) has been appropriately applied to this examination. Rectal emptying performed with DCP provides the maximum stress to the pelvic floor resulting in complete levator ani relaxation. In addition to diagnosing defecatory disorders, this method of examination demonstrates maximum pelvic organ descent and provides organ-specific quantification of organ prolapse, information that is only inferred by means of physical examination. It has been found to be of clinical value in patients with defecation disorders and the diagnosis of associated prolapse in other compartments that are frequently unrecognized by history taking and the limitations of physical examination. Pelvic floor anatomy is complex and DCP does not show the anatomical details pelvic magnetic resonance imaging (MRI) provides. Technical advances allowing acquisition of dynamic rapid MRI sequences has been applied to pelvic floor imaging. Early reports have shown that pelvic MRI may be a useful tool in pre-operative planning of these disorders and may lead to a change in surgical therapy. Predictions of hypothetical increase cancer incidence and deaths in patients exposed to radiation, the emergence of pelvic floor MRI in addition to questions relating to the clinical significance of DCP findings have added to these controversies. This review analyses the pros and cons between DCP and dynamic pelvic floor MRI, addresses imaging and interpretive controversies, and their relevance to clinical management. PMID:22446896

Maglinte, Dean D T; Hale, Douglass S; Sandrasegaran, Kumar



Do not disturb the animals! or, how Con Edison saved $300,000 using a trenchless technology to renew 3,000 feet of leaking gas main at the Bronx Zoo  

SciTech Connect

Every leaking gas main presents a challenge. But when that leaking main follows a series of sweeping bends on its route through North America`s largest urban wildlife park, it presents a special challenge. That was the situation Consolidated Edison Company of New York Inc. recently faced when numerous leaks were discovered along 3,000 feet of a 95-year-old, 12-inch cast-iron main that winds through New York City`s Bronx Zoo. Con Edison knew it needed a long-term solution to this increasingly common problem. Thanks to the cooperative efforts of the utility`s operations and research departments and the Gas Research Institute (GRI), Con Edison also knew about a trenchless technology that could renew the pipe with minimal impact to the environment--while saving the utility a substantial sum of money in the process. In the Paltem system, a woven polyester hose is injected with an epoxy resin and then inverted (turned inside out) into a pipe at an access pit. The liner then bonds to the inside wall of the pipe, forming a smooth, flexible and pressure-resistant lining. The process is environmentally safe, requires very little excavation and can be installed in days, rather than the weeks or months it can take to dig up and replace existing pipe.

Bufe, M.



Signals provided in vivo by human rIL-2 and Con A can switch hapten-specific tolerance from unresponsiveness to responsiveness in the South African clawed toad.  

PubMed Central

Injection in vivo of trinitrobenzene sulphonic acid (TNBS) will conjugate trinitrophenyl (TNP) to the cells and proteins of rodents, and induce hapten-specific tolerance to this epitope. However, the induction of hapten-specific tolerance by this method in the South African clawed toad, Xenopus laevis, is restricted to its subsequent presentation on Ficoll or polyvinylpyrrolidone (PVP). This restricted tolerance depends on the stimulation of an N-methyl-N-nitrosourea (NMU)-insensitive, cyclophosphamide (CyP)-sensitive hapten-specific (suppressor) population that is functionally demonstrable in vitro. Unresponsiveness to TNP-Ficoll can be switched to responsiveness by injection in vivo of recombinant DNA-produced human IL-2 (rIL-2) or the plant-derived lectin, concanavalin A (Con A). Responsiveness to TNP-Ficoll requires thymic presence, although thymic extracts from rIL-2- or Con A-injected toads will suffice. Unresponsiveness to TNP-PVP can also be broken by these reagents, but thymic presence is not required with this immunogen. TNP-Ficoll responses are thymus requiring, while those to TNP-PVP are not, in the toad. Since TNBS failed to stimulate hapten-specific tolerance to a secondary challenge to TNP-Ficoll, we suggest that the suppressor function involved in the establishment of the unresponsive state may act on the differentiation, rather than on the function, of the relevant B cells.

Ruben, L N; Clothier, R H; Mirchandani, M; Wood, P; Balls, M



Revision curricular a partir de un analisis comparativo de las discrepancias en los curriculos de una escuela de optometria en Puerto Rico con las competencias requeridas para las agencias de revalida y acreditacion 2004  

NASA Astrophysics Data System (ADS)

El proposito de esta investigacion, un estudio cualitativo de caso, fue comparar y contrastar el curriculo vigente de la Escuela de Optometria de la UIAPR con las competencias y estandares requeridos por las agencias de acreditacion y de revalida. Con este proposito, decidimos realizar una revision y un analisis de documentos: el prontuario de cada uno de los cursos de los curriculos implantados en el 1993 y en el 2001; las competencias y estandares establecidos por las agencias de revalida y de acreditacion; y las estadisticas en las que se analiza el porcentaje de estudiantes que aprueban cada una de las partes de los examenes de revalida entre el 1998 al 2003. Se realizaron entrevistas dirigidas para dar apoyo y complementar la revision y el analisis de estos documentos. Los participantes de las entrevistas fueron tres estudiantes de la clase de optometria del 2004 (ultima clase del curriculo del 1993); tres estudiantes de la clase de optometria del 2005 (primera clase graduanda del curriculo vigente) y tres profesores y/o directores de los Departamentos de Ciencias Basicas, Ciencias Clinicas y Cuidado al Paciente. Esta investigacion se enmarco en el modelo de evaluacion curricular de discrepancia de Malcolm Provus y en el modelo de desarrollo basado en competencias. Uno de los hallazgos mas importantes del estudio es que los cambios que se implantaron al curriculo del 2001 no han logrado que los estudiantes mejoren su ejecucion en los examenes de revalida. Por otro lado, se encontro que el curriculo vigente atiende completamente los estandares de la practica de Optometria, pero no las competencias. Esta informacion fue validada mediante el uso de una tabla de cotejo para el analisis de los cursos y de la informacion obtenida de las entrevistas. El estudio determina y concluye que existen discrepancias entre los prontuarios de los cursos del curriculo y las competencias requeridas por la agencia de revalida. Segundo, que el Departamento de Ciencias Basicas es el que presenta mas deficiencias en el desarrollo de las competencias. El investigador recomienda disenar e implantar un curriculo basado en competencias y proveer formacion en didactica y procesos de aprendizaje a los profesores.

Rivera Pacheco, Andres


Synthesis, characterization, and glutathionylation of cobalamin model complexes [Co(N4PyCO2Me)Cl]Cl2 and [Co(Bn-CDPy3)Cl]Cl2.  


Synthetic Co(III) complexes containing N5 donor sets undergo glutathionylation to generate biomimetic species of glutathionylcobalamin (GSCbl), an important form of cobalamin (Cbl) found in nature. For this study, a new Co(III) complex was synthesized derived from the polypyridyl pentadentate N5 ligand N4PyCO(2)Me (1). The compound [Co(N4PyCO(2)Me)Cl]Cl(2) (3) was characterized by X-ray crystallography, UV-vis, IR, (1)H NMR, and (13)C NMR spectroscopies and mass spectrometry (HRMS). Reaction of 3 with glutathione (GSH) in H(2)O generates the biomimetic species [Co(N4PyCO(2)Me)(SG)](2+) (5), which was generated in situ and characterized by UV-vis and (1)H NMR spectroscopies and HRMS. (1)H NMR and UV-vis spectroscopic data are consistent with ligation of the cysteine thiolate of GSH to the Co(III) center of 5, as occurs in GSCbl. Kinetic analysis indicated that the substitution of chloride by GS(-) occurs by a second-order process [k(1) = (10.1 ± 0.7) × 10(-2) M(-1) s(-1)]. The observed equilibrium constant for formation of 5 (K(obs) = 870 ± 50 M(-1)) is about 3 orders of magnitude smaller than for GSCbl. Reaction of the Co(III) complex [Co(Bn-CDPy3)Cl]Cl(2) (4) with GSH generates glutathionylated species [Co(Bn-CDPy3)(GS)](2+) (6), analogous to 5. Glutathionylation of 4 occurs at a similar rate [k(2) = (8.4 ± 0.5) × 10(-2) M(-1) s(-1)], and the observed equilibrium constant (K(obs) = 740 ± 47 M(-1)) is slightly smaller than for 5. Glutathionylation showed a significant pH dependence, where rates increased with pH. Taken together, these results suggest that glutathionylation is a general reaction for Co(III) complexes related to Cbl. PMID:22316335

Prakash, Jai; Kodanko, Jeremy J



Síndrome de Stevens-Johnson y necrólisis epidérmica tóxica por profilaxis con TARGA en el Hospital Nacional Almanzor Aguinaga Asenjo, Lambayeque,Perú Stevens Johnson syndrome and toxic epidermal necrolysis induced by HAART prophylaxis in the National Hospital Almanzor Aguinaga Asenjo, Lambayeque, Perú  

Microsoft Academic Search

RESUMEN Síndrome de Stevens-Johnson (SSJ) y necrólisis epidérmica tóxica (NET) son reacciones inflamatorias agudas originadas por hipersensibilidad (reacción inmunológica), que incluye piel y membranas mucosas. Se presenta un caso de reacción adversa medicamentosa en un paciente varón de 25 años, que recibió profilaxis con Terapia Antiretroviral de Gran Actividad. Presentó exantema, que progresa a SSJ y evoluciona a NET. Permaneció

Victor A. Soto Cáceres; Rosa E. Rodríguez Barboza



Has allogeneic stem cell cryopreservation been given the 'cold shoulder'? An analysis of the pros and cons of using frozen versus fresh stem cell products in allogeneic stem cell transplantation.  


Donor stem cells for allogeneic transplant traditionally are collected and transfused 'fresh' into the recipient on the day of transplant; alternatively such cells can be collected in advance and cryopreserved until needed. Most centers favor the former approach based on theoretical concerns that cryopreservation and thawing may worsen clinical outcomes. Limited published data from single institution retrospective studies show no significant impairment of engraftment or reduced day 100 survival for cryopreserved bone marrow recipients. There are no reported outcomes for recipients of cryopreserved peripheral blood allografts. Use of cryopreserved stem cells is associated with a higher incidence of adverse events (transfusion reactions, bacterial graft contamination and collection of grafts which are not utilized). Conversely, use of cryopreserved grafts introduces a greater flexibility into a stressed healthcare system and results in a more streamlined experience for the donor. Some data suggest that transplantation with a cryopreserved product may lower the incidence of acute graft-versus-host disease. We compare the pros and cons of using 'fresh' versus cryopreserved stem cell products for allogeneic transplantation and suggest that the current standard of using 'fresh' products may not be warranted. We also suggest future areas of exploration to better elucidate this issue. PMID:16892075

Frey, N V; Lazarus, H M; Goldstein, S C



Brewers' spent grain (BSG) protein hydrolysates decrease hydrogen peroxide (H2O2)-induced oxidative stress and concanavalin-A (con-A) stimulated IFN-? production in cell culture.  


The present study investigated the bioactivity of protein hydrolysates and fractionated hydrolysates prepared from brewers' spent grain (BSG) using proteases, including Alcalase 2.4L, Flavourzyme and Corolase PP. Hydrolysates were designated K-Y, including fractionated hydrolysates with molecular weight (m.w.) < 3, <5 and >5 kDa. Where computable, IC50 values were lower in U937 (1.38-9.78%) than Jurkat T cells (1.15-13.82%). Hydrolysates L, Q and R and fractionated hydrolysates of U and W (<3, <5, >5 kDa) significantly (P < 0.01) protected against hydrogen peroxide (H2O2)-induced reduction of superoxide dismutase (SOD) activity. A fractionated hydrolysate of W (<5 kDa) protected against H2O2-induced DNA damage, P < 0.01. Hydrolysates K, N, P, U, U > 5 kDa, V, V > 5 kDa, W, W > 5 kDa significantly (P < 0.05) reduced a concanavlin-A (con-A) stimulated production of interferon-? (IFN-?). In conclusion, BSG protein hydrolysates demonstrate bioactivity in vitro; lower m.w. hydrolysates (<3, <5 kDa) show greatest antioxidant activity and unfractionated or higher m.w. hydrolysates (>5 kDa) possess anti-inflammatory effects. PMID:24113874

McCarthy, Aoife L; O'Callaghan, Yvonne C; Connolly, Alan; Piggott, Charles O; Fitzgerald, Richard J; O'Brien, Nora M



The office surgical suite: pros and cons.  


Today interest and enthusiasm regarding facial plastic surgery is burgeoning. Office surgery provides a new, more expedient, comfortable method of delivery of health care while directly responding to the growing concern among the public and government for improved cost containment of medical services. Awareness of improved surgical techniques and facilities will help to ensure tomorrow's continued growth and satisfaction for both the surgeon and his patient. PMID:7393580

Simons, R L



Pros and cons of subpectoral implantation.  


At the present time, there is no universally accepted surgical technique or prosthesis for augmenting breast volume. Each surgeon has to choose with regard to shape, consistency, and volume, according to his own conviction and respecting his patient's priorities. These priorities will vary with age, profession, sexual habits, and marital and social status. In order to get the best possible results, the plastic surgeon should be adept at alternative methods and should not be restricted to one technique or one prosthesis. Patients vary considerably so our methods should be diversified. Our subpectoral implantations have given us better results than our retroglandular ones, which have been performed during the same period of time and with the same prosthesis. Consequently, retropectoral implantation is still our preferred procedure. We think that this technique, with its proper indications, deserves wider application. PMID:1261186

Papillon, J



La relazione analitica con i pazienti schizoidi  

Microsoft Academic Search

da molti anni che mi dedico a mettere in luce il funzionamento dei pazienti schizoidi. Non già a comprendere il Disturbo Schizoide di Personalità descritto in tassonomie psichiatriche come il DSM, ma la let- tura psicoanalitica fenomenologica delle problematiche schizoidi. Ho sempre avuto un grande interesse ad esplorare le differenze individuali più che a definire ciò che è o non

Nancy McWilliams


Análisis de Variabilidad con Modelos de Objetivos  

Microsoft Academic Search

Dentro del campo de la variabilidad, o la habilidad de cambio o personalización de un sistema, no es común que dicha variabilidad se tenga en cuenta en la definición de requisitos. En las propuestas donde si se contemplan se utilizan directamente features, aunque no son una técnica de elicitación de requisitos, sino que más bien están a medio camino entre

Bruno González-Baixauli; Miguel A. Laguna; Sampaio do Prado



Pros and cons of apartment complex submetering  

Microsoft Academic Search

Mastermetering was popular when energy costs were low, but landlords can no longer raise rents fast enough to keep up with rising utility costs. Individual metering and submetering are a growing trend in Texas in order to regulate cash flow and keep rents competitive. Individual metering encourages conservation, but reduces the owner's incentives to improve building efficiency. Owners may not

G. Reichelt; J. Jones



Tratamiento nutricional del niño con trastorno neuromotor  

Microsoft Academic Search

The risk of suffering malnutrition is very high in children and adolescents who suffer a certain type of neuromotor pathology (NP) due to different factors that occur in them: motor coordination disorders in the different stages of deglutition, gastroesophageal reflux, oesophagitis, gastritis, gastrocolic reflex alteration, constipation, anorexia, etc. These disorders alter the desirable proportionality between the amount of food given

Isabel Polanco Allué



Cálculos ab initio con correlación electrónica  

Microsoft Academic Search

Estamos entrando en una era donde la ortogonalidad entre las investigaciones de carácter experimental y de naturaleza teórica se irá difuminando progresivamente y la problemática a resolver quedará en escena como el único actor principal de la obra. Como premisa para una cooperación teórico-experimental de igual a igual, la metodología químico-cuántica utilizada debe ser capaz de ofrecer resultados de carácter

M. Merchán Bonete



Polarimetría de estrellas con discos de ``escombros''  

NASA Astrophysics Data System (ADS)

We present optical polarimetric measurements of a set of ˜100 solar-type stars with and without debris disks. The selection of these objects were based on the presence of excesses in the spectral energy distributions. This sample is complemented with a group of stars from the northern hemisphere with similar characteristics. A statistical comparison of the stars with and without disk shows no significant differences in the observed polarizations. However, we identified a subset of objects (<10 % of the whole sample) with polarizations above the median that not follow the Law of Serkowsky. These polarizations might be due to the presence of disks. FULL TEXT IN SPANISH

García, L.; Gómez, M.


Dismenorrea por útero unicorne con cuerno rudimentario  

Microsoft Academic Search

Dysmenorrhea is highly frequent in adolescents and young women, affecting 40-50% of this population to some degree.Unicornuate uterus with rudimentary horn and functional endometrium can cause dysmenorrhea due to the distension produced by blood in a closed cavity and the consequent development of hematometra, hematosalpinx, and retrograde menstruation. Treatment is necessarily surgical and the recommended intervention is excision of the

Borja Rivero; Iurdana Aizpitarte; Ainhoa Elvira; José Ramón Becerro



Alteraciones dermatológicas en pacientes con anemias carenciales  

Microsoft Academic Search

Objectives: To determine the frequency of anemia-related dermatological abnormalities and severity. Materials and Methods: A sample of 100 subjects older than 18 years with a diagnosis of nutritional anemia who were admitted at 2 de Mayo Hospital between January and November, 2004 was studied. In each subject we measured total CBC and serum iron, ferritin, folate, and cobalamin levels. Results:

Oscar Ruiz; Luz Bardales; David Díaz; Carlos Galarza; Carlos Delgado; Oscar Castillo; Manuela Marangoni; Carlos Montenegro



The Pros and Cons of Petroleum Agreements.  

ERIC Educational Resources Information Center

A mineral agreements expert discusses the options open to tribes, from the most standard lease form to arrangements as yet untried by Indian Nations. Discussion covers 18 basic provisions for inclusion in agreements, tax considerations, and basic forms of petroleum agreements (leases, joint ventures, production sharing, and service contracts).…

Lipton, Charles J.



Localización de Insulinoma Pancreático con Ultrasonografía Laparoscópica  

Microsoft Academic Search

The case of a 51-year-old woman with a clinical history of hipoglicemia caused by a presumed pancreatic insulinoma is reported. Laboratory tests pointed out for a insulinoma, but imaginologic studies could not locate the tumor. Under this circumstances, the patient was laparoscopically approached. By means of the ultrasononography device the tumor was located at the uncinate process of the pancreas

Francisco Berrospi Espinoza; Juan Celis Zapata; Eloy Ruiz Figueroa; Iván Chavez


Stepwise versus Hierarchical Regression: Pros and Cons  

ERIC Educational Resources Information Center

Multiple regression is commonly used in social and behavioral data analysis. In multiple regression contexts, researchers are very often interested in determining the "best" predictors in the analysis. This focus may stem from a need to identify those predictors that are supportive of theory. Alternatively, the researcher may simply be interested…

Lewis, Mitzi



Vencemos Con Libros Y La Lengua.  

National Technical Information Service (NTIS)

The city of Richmond, California has many residents who read and speak only Spanish, and many other Chicanos and Latin Americans who are interested in their heritage. The Service Center Branch of the public library has a collection of books, magazines, an...

D. F. Duran



Nanoparticles: Health Effects--Pros and Cons  

PubMed Central

With the advent of nanotechnology, the prospects for using engineered nanomaterials with diameters of < 100 nm in industrial applications, medical imaging, disease diagnoses, drug delivery, cancer treatment, gene therapy, and other areas have progressed rapidly. The potential for nanoparticles (NPs) in these areas is infinite, with novel new applications constantly being explored. The possible toxic health effects of these NPs associated with human exposure are unknown. Many fine particles generally considered “nuisance dusts” are likely to acquire unique surface properties when engineered to nanosize and may exhibit toxic biological effects. Consequently, the nuisance dust may be transported to distant sites and could induce adverse health effects. In addition the beneficial uses of NPs in drug delivery, cancer treatment, and gene therapy may cause unintentional human exposure. Because of our lack of knowledge about the health effects associated with NP exposure, we have an ethical duty to take precautionary measures regarding their use. In this review we highlight the possible toxic human health effects that can result from exposure to ultrafine particles (UFPs) generated by anthropogenic activities and their cardiopulmonary outcomes. The comparability of engineered NPs to UFPs suggests that the human health effects are likely to be similar. Therefore, it is prudent to elucidate their toxicologic effect to minimize occupational and environmental exposure. Highlighting the human health outcomes caused by UFPs is not intended to give a lesser importance to either the unprecedented technologic and industrial rewards of the nanotechnology or their beneficial human uses.

Gwinn, Maureen R.; Vallyathan, Val



Roofing with Urethane: Pro and Con.  

ERIC Educational Resources Information Center

|Gerald Scott's favorable evaluation of the foamed polyurethane roofing system is based on experiences with 55 buildings at Texas A & M. Michael Kinzer, an architect at Colorado State University, disagrees and claims that the system is difficult to install and maintain, and the cost prohibitive. (MLF)|

Kinzer, Michael; Scott, Gerald P.E.



Planetas extrasolares con pequeño semieje orbital  

NASA Astrophysics Data System (ADS)

The discovery of extra-solar planets, first surrounding a pulsar (PSR1257+12, Malhotra et al 1992) and then main-sequence stars similar to our sun, ( has opened a new field of study inside the dynamic of planetary systems. Although the information we have of these objects is determined by the own limitations of the detection methods that are used, important differences between these systems and the Solar System were observed. The mass of these planets are, in general, bigger than Jupiter, the measured semimayor axes have a low limit of 0.04 AU, the ten part of Mercury semimayor axe. Further, the excentricities take different values from almost 0 to 0.93, in contrast to our system where the planetary orbits are approximately circular. Among the extra solar planets detected until August 2002, it is possible to observe a deficiency of massive planets (Mp sin I < 3.5 Mj) near the primary star, i.e. semimayor axe below 0.1 AU, with excentricity below 0.2. The goal of this work is to attempt an explanation of these cases by an eliptic planar model in which two point planets interac gravitationaly. The motion equations are analized for different initial conditions by using numerical methods. The motion equations were stated and several pairs of particles were generated by varying the relative masses and the orbital elements. To integrate the equations the Bulirsh - Stoer code was used, with a 10-12 accuracy. As a control variable of the results the calculus of energy was used. The total span of integrations was 106 years. The outputs of the numerical simulations show several dynamic behaviors for the particles: - Lower mass escapes to the outside of the system - Stability in both bodies - Less massive planet fall to the primary star Moreover, by comparing the results obtained for objets with identical initial conditions in their orbital parameters, but with different relations of mass, it is possible to distinguish two types of behaviours: - during the integration time there is dynamical estability if both masses are below 3.5Mj. - the less massive planet fall to the star if the other mass is about 10Mj. in this case the major body increase his semimajor axe in order to preserve the constancy of the angular moment of the total system. The simulations performed have shown results with a high dependence of the values of the initial conditions and the masses of the planets considered.

Giuliodori, D.; Fernández, S.


Coal gasification\\/pros and cons  

Microsoft Academic Search

About 80% of total remaining U.S. fossil fuel resource is in the form of coal. World oil production is expected to peak not later than 2000; a precipitous rise in world oil prices can be expected. Currently SNG from coal at a cost of $3.50 to $4.50\\/million Btu, is equivalent to oil at $15 to $25\\/bbl. Low-Btu gas from coal



The pros and cons of phytoestrogens  

PubMed Central

Phytoestrogens are plant derived compounds found in a wide variety of foods, most notably soy. A litany of health benefits including a lowered risk of osteoporosis, heart disease, breast cancer, and menopausal symptoms, are frequently attributed to phytoestrogens but many are also considered endocrine disruptors, indicating that they have the potential to cause adverse health effects as well. Consequently, the question of whether or not phytoestrogens are beneficial or harmful to human health remains unresolved. The answer is likely complex and may depend on age, health status, and even the presence or absence of specific gut microflora. Clarity on this issue is needed because global consumption is rapidly increasing. Phytoestrogens are present in numerous dietary supplements and widely marketed as a natural alternative to estrogen replacement therapy. Soy infant formula now constitutes up to a third of the US market, and soy protein is now added to many processed foods. As weak estrogen agonists/antagonists with molecular and cellular properties similar to synthetic endocrine disruptors such as Bisphenol A (BPA), the phytoestrogens provide a useful model to comprehensively investigate the biological impact of endocrine disruptors in general. This review weighs the evidence for and against the purported health benefits and adverse effects of phytoestrogens.

Patisaul, Heather B.; Jefferson, Wendy



Distance Education: Pros, Cons, and the Future.  

ERIC Educational Resources Information Center

This paper reviews recent publications on distance education and explores its promise and potential from the student's perspective, the faculty's perspective and the administrator's perspective. Findings indicate that only the self-motivated and self-disciplined students are most likely to succeed in distance education. Although the majority of…

Li, Hongmei


Omega-3 in antiarrhythmic therapy : cons position.  


The association between omega-3 (n-3 polyunsaturated fatty acids) and the clinical outcome of patients with cardiovascular diseases such as coronary heart disease is currently unclear, especially regarding its possible antiarrhythmic effects and the not quite understood mechanisms of action. In the last 15 years, several epidemiological studies have shown a lower incidence of sudden cardiac death with a diet rich in omega-3 or fish consumption. The antiarrhythmic properties related to omega-3 have been related to modulation of sodium-dependent ion channels or sodium-calcium exchangers of myocytes through a reduction of their excitability especially in ischaemic or damaged myocardial tissue. However, the results of experimental studies have not always been consistent. Although the role of omega-3 in preventing sudden cardiac death has been evaluated in several clinical trials that included patients with coronary artery disease (particularly in patients with post-myocardial infarction), the interpretation of such data must be treated with extreme caution. In particular, while a reduction in cardiac death was demonstrated by a meta-analysis of several randomized clinical trials, a reduced risk of sudden cardiac death has been described only in the GISSI-Prevenzione study, while in other studies the evidence that emerged is more controversial, with wide confidence intervals that support the possibility of heterogeneity in the distribution of the factors involved in the efficacy of treatment. Omega-3 is probably involved in the prevention of cardiovascular mortality through different mechanisms, and it is crucial to study its association with other drugs such as ACE inhibitors or calcium channel blockers. The study of antiarrhythmic drugs has been divided into prevention of supraventricular and ventricular arrhythmias. In these conditions, the role of omega-3 seems to be more pronounced in atrial tachyarrhythmias such as atrial fibrillation, but does not have a role in ventricular arrhythmias. In summary, the antiarrhythmic effect of omega-3 is not clearly evident and further studies are needed to investigate its beneficial effect in cardiac mortality compared with arrhythmic death. PMID:23430665

Borghi, Claudio; Pareo, Ilenia



Payment for donor kidneys: pros and cons.  


Continuous growth of the end stage renal disease population treated by dialysis, outpaces deceased donor kidneys available, lengthens the waiting time for a deceased donor transplant. As estimated by the United States Department of Health & Human Services: '17 people die each day waiting for transplants that can't take place because of the shortage of donated organs.' Strategies to expand the donor pool--public relations campaigns and Drivers' license designation--have been mainly unsuccessful. Although illegal in most nations, and viewed as unethical by professional medical organizations, the voluntary sale of purchased donor kidneys now accounts for thousands of black market transplants. The case for legalizing kidney purchase hinges on the key premise that individuals are entitled to control of their body parts even to the point of inducing risk of life. One approach to expanding the pool of kidney donors is to legalize payment of a fair market price of about 40,000 dollars to donors. Establishing a federal agency to manage marketing and purchase of donor kidneys in collaboration with the United Network for Organ Sharing might be financially self-sustaining as reduction in costs of dialysis balances the expense of payment to donors. PMID:16482095

Friedman, E A; Friedman, A L



Payment for donor kidneys: Pros and cons  

Microsoft Academic Search

Continuous growth of the end stage renal disease population treated by dialysis, outpaces deceased donor kidneys available, lengthens the waiting time for a deceased donor transplant. As estimated by the United States Department of Health & Human Services: ‘17 people die each day waiting for transplants that can’t take place because of the shortage of donated organs.’ Strategies to expand

E A Friedman; A L Friedman



Construyendo con Ladrillo (Building with Brick).  

National Technical Information Service (NTIS)

The purpose of the manual is to present, in tutorial form, the concepts and procedures of engineering needed to construct a practical home at minimum costs and with maximum protection from the elements, including earthquakes. Covered in detail are: (1) Pa...



Natural-born con artists and counterfeiters  

PubMed Central

Deception is ubiquitous in plant and animal kingdoms and is widely thought to provide selective advantages to the individual and evolutionary success to the species. Mimicry, a form of deception whereby an individual imitates their model to advantage by closely resembling their behavior or appearance, is particularly well documented and represented by the peripheral eyespots seen on the wings of many butterfly species. The significance of butterfly eyespots has been convincingly demonstrated to serve as an anti-predatory function either by imitation of a predator’s own dangerous enemies (intimidation hypothesis) or by deflecting predator strikes toward less-vital parts of the body (deflection hypothesis). A convincing and compelling explanation in butterflies, the functional role of eyespots as anti-predatory devices has become a widely held and firmly entrenched belief that has been freely adopted into other systems. Here we comment on a recent paper that demonstrates a vastly different role for eyespots, that of intra-specific male-male competition, and make the point that even long-held beliefs need to be tested and challenged under different contexts if we are not to be deceived ourselves.

Depczynski, Martial; Gagliano, Monica



Nuclear issues: weighing the pros and cons  

Microsoft Academic Search

Some of the controversial issues over radioactivity release, accident potential, security, waste management, and plutonium are reviewed in terms of weighing potential and existing risks of nuclear energy against the benefits. Many areas in Canada have found uranium fuel to be competitive and more readily available than other energy sources. Comparisons of nuclear and coal-fired plants over a 30-year service




Farmacoterapia en el paciente con claudicación intermitente  

Microsoft Academic Search

Intermittent claudication is the most common symptom of peripheral arterial disease. Besides the limitation in the quality of life of the patient, it represents an independent risk factor and high cardiovascular mortality. The overall treatment strategy begins with an adequate control of vascular risk factors and lifestyle habits of the patient. We also associate drugs to reduce the occurrence of

A. Rodríguez-Morata; C. Esteban-Gracia; A. Fernández-Heredero; R. Riera-Vázquez; F. Vaquero-Lorenzo; J. R. March-García



Mandatory Arbitration: Weighing the Pros and Cons  

ERIC Educational Resources Information Center

|When big businesses enter into mandatory arbitration agreements with consumers, the large companies typically tout the fairness while the individual is left feeling cheated. Now that mandatory arbitration clauses are finding their way into more and more contracts signed by school systems, school boards and district administrators are realizing…

Settenbrino, Susan D.



Weighing the Pros and Cons of TAP  

ERIC Educational Resources Information Center

|Headlines offer a plethora of opinions and arguments both for and against proposed and newly implemented teacher evaluation systems all over the United States. Hardly anyone balks at the idea of evaluating teachers, but many question whether these new evaluation systems really improve teaching and learning. The author's experience with the new…

Pieczura, Michelle



Perfil inmunológico del paciente con esporotricosis linfocutánea  

Microsoft Academic Search

Sporotrichosis is characterized by a wide range of clinical manifestations from mild fixed cutaneous forms to systemic dissemination of the disease, despite an apparent regular pattern of virulence of the etiological agent, S. schenckii. These facts suggest that immunological mechanisms of the host could play an important role on the pathogenesis of the mycosis. On this basis, an immunologic survey

Consuelo E. Meléndez Ruiz; Amado Gonzfilez Mendoza; José Manuel Sotomayor; Victor M. Ruiz Godoy; Rodolfo Ramos Zepeda



The Big Con: China's Historical Sabotage  

ERIC Educational Resources Information Center

|On June 4, 1989, the Chinese military, under orders from the highest levels of government, violently crushed peaceful civilian demonstrations in Beijing, most symbolically in and around Tiananmen Square. In the end, the Chinese government claimed that the death toll was approximately 200, but the Chinese Red Cross reported 2,000 to 3,000 deaths.…

Terrence Cheng



Hester Prynne as Role Model: Pro & Con.  

ERIC Educational Resources Information Center

|McWalters denies DeSalvo's previous claim (see EJ 209 302) that "The Scarlet Letter" harms students through its message of repressed sexuality; he suggests that the book does not condemn sexuality. DeSalvo replies that "The Scarlet Letter" is presented to students in a harmful way; she again calls for the use of literature that celebrates…

McWalters, John B.; DeSalvo, Louise



Mandatory Arbitration: Weighing the Pros and Cons  

ERIC Educational Resources Information Center

When big businesses enter into mandatory arbitration agreements with consumers, the large companies typically tout the fairness while the individual is left feeling cheated. Now that mandatory arbitration clauses are finding their way into more and more contracts signed by school systems, school boards and district administrators are realizing…

Settenbrino, Susan D.



[Debate about breast cancer: "Cons: Intraoperative radiotherapy"].  


Early breast cancer incidence increases owing to mammography screening. Hypofractionated radiotherapy is more and more proposed in women with low local relapse risk breast cancer, especially accelerated partial breast irradiation. Various irradiation modalities have been reported: brachytherapy, intraoperative irradiation, 3D-conformal accelerated partial breast irradiation. We describe limitations of intraoperative irradiation and the advantages of alternative techniques. PMID:21795091

Bourgier, C; Heymann, S; Verstraet, R; Biron, B; Marsiglia, H



[Legalization of drugs--pro and con].  


This article deals with various opinions and assertions regarding drug legalization. Societal and clinical implication regarding the effect of decrease or increase in the use of psyhoactive substances, on public health, violence and criminal activities have been pointed out. The relation between legal and illegal drugs has been considered. Special attention has been paid to arguments on legalization and decriminalization of marihuana and possible consequences on the risk group-children and adolescents. Experiences from USA and some European countries have been presented. Having in mind the specific situation in BiH, the author of article gives her own view and suggest the introduction of harm reduction strategy into BiH drug policy, without changing the legal drug status. PMID:11769432

Marjanovi?-Cengi?, S




Microsoft Academic Search

The reunion with the Graphic Figuration: A methodologic proposal for the visual and plastic education in Secondary Level The eternal question: Why do we become ourselves to inhibited adults and inhibited youth at the time to manifest ourselves with the plastic language?. In the plastic and visual education in the secondary level, we find ourselves with the pupils that always




Microsoft Academic Search

band would play for shows and dances. Although Jack and the other band members promised to take good care of young Ron, the under-age musician admits to hearing lots of dirty jokes, which he thoroughly enjoyed With his father, being a fine musician himself, playing old time fiddle music, Ron was fortunate to be exposed to all the talent of



Investigaccion-accion en la sala de clases sobre las creencias de la cultura de la ciencia de un grupo de estudiantes universitarios y su relacion reciproca con el aprendizaje de las ciencias biologicas  

NASA Astrophysics Data System (ADS)

La investigacion---accion que se llevo a cabo en la sala de clases tenia como punto de partida las creencias de la cultura de la ciencia de un grupo de estudiantes universitarios para luego examinar sus implicaciones en el proceso de aprendizaje de las Ciencias Biologicas. ¿Que se supone que hagan las creencias en relacion con el aprendizaje? ¿En que consiste incorporar este aspecto a la practica educativa universitaria? Utilizando el modelo de Kemmis y McTaggart (1987) la investigacion-accion se planteo como un proceso dinamico en cuatro momentos en espiral constituidos por la planificacion, la accion, la observacion y la reflexion. Cada una de las fases tuvo una intencion retrospectiva y prospectiva formando una espiral de autorreflexion del conocimiento y la accion. Se llevaron a cabo audio grabaciones en clases y analisis de documentos. Ademas, la profesora-investigadora hizo un portafolio para reflexionar sobre las creencias de la cultura de la ciencia que tienen los estudiantes y las creencias del aprendizaje que tiene la profesora y sobre como la comprension de estos elementos ayudo a mejorar su practica educativa a traves del tiempo. Los resultados obtenidos apuntan a que las creencias de la cultura de la ciencia que tiene el grupo de estudiantes son diversas. Ellos si creen que la ciencia tiene una cultura la cual describieron como: complicada y desconocida que evoluciona constantemente, que es un conjunto de metodos, que es altamente tecnologica, que resuelve problemas de salud, ayuda a interpretar la realidad del mundo que los rodea y su origen y que existen unas intersecciones entre la ciencia y el poder. Sobre las creencias del proceso de aprendizaje de la profesora-investigadora, estas senalan que el modelaje de actores, la vision de la academia que tiene ella asi como la participacion y negociacion entre todos los involucrados en el proceso educativo, son factores que inciden en el proceso de aprendizaje.

Cordova-Santiago, Lizzette Astrid


WGS Catalysis and In Situ Studies of CoO1-x, PtCon/Co3O4, and PtmCom'/CoO1-x Nanorod Catalysts.  


Water-gas shift (WGS) reactions on Co3O4 nanorods and Co3O4 nanorods anchoring singly dispersed Pt atoms were explored through building correlation of catalytic performance to surface chemistry of catalysts during catalysis using X-ray absorption spectroscopy, ambient pressure X-ray photoelectron spectroscopy (AP-XPS), and environmental TEM. The active phase of pure Co3O4 during WGS is nonstoichiometric cobalt monoxide with about 20% oxygen vacancies, CoO0.80. The apparent activation energy (Ea) in the temperature range of 180-240 °C is 91.0 ± 10.5 kJ mol(-1). Co3O4 nanorods anchoring Pt atoms (Pt/Co3O4) are active for WGS with a low Ea of 50.1 ± 5.0 kJ mol(-1) in the temperature range of 150-200 °C. The active surface of this catalyst is singly dispersed Pt1Con nanoclusters anchored on Co3O4 (Pt1/Co3O4), evidenced by in situ studies of extended X-ray absorption fine structure spectroscopy. In the temperature range of 200-300 °C, catalytic in situ studies suggested the formation of PtmCom' nanoclusters along with the reduction of Co3O4 substrate to CoO1-x. The new catalyst, PtmCom'/CoO1-x is active for WGS with a very low Ea of 24.8 ± 3.1 kJ mol(-1) in the temperature range of 300-350 °C. The high activity could result from a synergy of PtmCom' nanoclusters and surface oxygen vacancies of CoO1-x. PMID:23611190

Zhang, Shiran; Shan, Jun-Jun; Zhu, Yuan; Frenkel, Anatoly I; Patlolla, Anitha; Huang, Weixin; Yoon, Seog Joon; Wang, Lei; Yoshida, Hideto; Takeda, Seiji; Tao, Franklin Feng



Extraction and coordination studies of the unexplored bifunctional ligand carbamoyl methyl sulfoxide (CMSO) with uranium(VI) and cerium(III) nitrates. Synthesis and structures of [UO2(NO3)2(PhSOCH2CON(i)Bu2)] and [Ce(NO3)3(PhSOCH2CONBu2)2].  


The bifunctional carbamoyl methyl sulfoxide ligands, PhCH(2)SOCH(2)CONHPh (L1), PhCH(2)SOCH(2)CONHCH(2)Ph (L2), PhSOCH(2)CON(i)Pr(2)(L3), PhSOCH(2)CONBu(2)(L4), PhSOCH(2)CON(i)Bu(2)(L5) and PhSOCH(2)CON(C(8)H(17))(2)(L6) have been synthesized and characterized by spectroscopic methods. The selected coordination chemistry of L1, L3, and L5with [UO(2)(NO(3))(2)] and [Ce(NO(3))(3)] has been evaluated. The structures of the compounds [UO(2)(NO(3))(2)(PhSOCH(2)CON(i)Bu(2))](10) and [Ce(NO(3))(3)(PhSOCH(2)CONBu(2))(2)](12) have been determined by single crystal X-ray diffraction methods. Preliminary extraction studies of ligand L6 with U(VI), Pu(IV) and Am(III) in tracer level showed an appreciable extraction for U(VI) and Pu(IV) in up to 10 M HNO(3) but not for Am(III). Thermal studies on compounds 8 and 10 in air revealed that the ligands can be destroyed completely on incineration. The electron spray mass spectra of compounds 8 and 10 in acetone show that extensive ligand distribution reactions occur in solution to give a mixture of products with ligand to metal ratios of 1: 1 and 2 :1. However, 10 retains its solid state structure in CH(2)Cl(2). PMID:15510283

Kannan, Shanmugaperumal; Chetty, Kuna Venugopal; Venugopal, Venkatarama; Drew, Michael G B




Microsoft Academic Search

RIASSUNTO Scopo del lavoro è stato determinare l'effetto dell 'insilato di mais rispetto al fieno, come principal e componente della dieta, sul tenore azotato urinario. Secondo u n piano sperimentale a cross over 2x2, 14 bovine di razza Frisona (212±99 gg. lattazione e 26.7±5.9 kg latte\\/ d) sono state alimentate con due diete isoenergetic he, isoproteiche e isofibrose. Dopo tre


Debate: Does genetic information in humans help us treat patients? PRO--genetic information in humans helps us treat patients. CON--genetic information does not help at all.  


PRO: In the past decade, genotyping has started to help the neurologic practitioner treat patients with three types of epilepsy causing mutations, namely (1) SCN1A, a sodium channel gene mutated in Dravet's sporadic severe myoclonic epilepsy of infancy (SMEI and SMEB); (2) laforin (dual specificity protein phosphatase) and malin (ubiquitin E3 ligase) in Lafora progressive myoclonic epilepsy (PME); and (3) cystatin B in Unverricht-Lundborg type of PME. Laforin, malin, and cystatin B are non-ion channel gene mutations that cause PME. Genotyping ensures accurate diagnosis, helps treatment and genetic counseling, psychological and social help for patients and families, and directs families to organizations devoted to finding cures for specific epilepsy diseases. In SCN1A and cystatin B mutations, treatment with sodium channel blockers (phenytoin, carbamazepine, oxcarbazepine, lamotrigine) should be avoided. Because of early and correct diagnosis by genotyping of SCN1A mutations, the avoidance of sodium channel blockers, and aggressive treatment of prolonged convulsive status, there is hope that Dravet's syndrome may not be as severe as observed in all past reports. Genotyping also identifies nonsense mutations in Lafora PME. Nonsense mutations can be corrected by premature stop codon readthrough drugs such as gentamicin. The community practitioner together with epilepsy specialists in PME can work together and acquire gentamicin (Barton-Davis et al., 1999) for "compassionate use" in Lafora PME, a generalized lysosome multiorgan storage disorder that is invariably fatal. In Unverricht-Lundborg PME, new cohorts with genotyped cystatin B mutations have led to the chronic use of antioxidant N-acetylcysteine and combination valproate clobazam or clonazepam plus antimyoclonic drugs topiramate, zonisamide, piracetam, levetiracetam, or brivaracetam. These cohorts have minimal ataxia and no dementia, questioning whether the syndrome is truly progressive. In conclusion, not only is genotyping a prerequisite in the diagnosis of Dravet's syndrome and the progressive myoclonus epilepsies, but it also helps us choose the correct antiepileptic drugs to treat seizures in Dravet's syndrome and Unverricht-Lundborg PME. Genotyping also portends a brighter future, helping us to reassess the true course, severity, and progressive nature of Dravet's syndrome and Unverricht-Lundborg PME and helping us craft a future curative treatment for Dravet's syndrome and Lafora disease. Without the genotyping diagnosis of epilepsy causing mutations we are stuck with imprecise diagnosis and symptomatic treatment of seizures. CON: Genotyping of epilepsy may help to better understand the genetics of epilepsy, to establish an etiology in a patient with epilepsy, to provide genetic counseling, and to confirm a clinical diagnosis. However, critical analysis reveals that genotyping does not contribute to an improved treatment for the patients. In order to improve treatment, genotyping would have to (1) improve our ability to select the drug of choice for a given epilepsy or epileptic syndrome; (2) improve our ability to predict the individual risk of adverse reactions to certain drugs; (3) improve our ability to avoid unnecessary treatments or treatments that could aggravate seizures. Many example illustrate the lack of impact of genetic information on the treatment outcome: we do not treat Dravet syndrome more successfully since SCN1A testing became available; we do not treat Lafora disease more successfully since testing for laforin and malin became available; we do not need to know the genetic nature of Unverricht-Lundborg disease or test for the cystatin B mutation in order to select or avoid certain drugs; we do not treat Rett syndrome more successfully since MECP2 testing became available; we do not treat JME more successfully since we know its genetic origin; we do not treat autosomal dominant nocturnal frontal lobe epilepsy more successfully since we know its genetic origin and can test for its mutation. The clinical characteristics as well as the

Delgado-Escueta, Antonio V; Bourgeois, Blaise F D



The nature of the Ailao Shan-Red River (ASRR) shear zone: Constraints from structural, microstructural and fabric analyses of metamorphic rocks from the Diancang Shan, Ailao Shan and Day Nui Con Voi massifs  

NASA Astrophysics Data System (ADS)

The structural geology, timing of shearing, and tectonic implications of the ASRR shear zone, one of the most striking lineaments in Southeast Asia, have been the topics of extensive studies over the past few decades. The Xuelong Shan (XLS), Diancang Shan (DCS), Ailao Shan (ALS) and Day Nui Con Voi (DNCV) metamorphic massifs along the shear zone have preserved important information on its structural and tectonic evolution. Our field structural analysis, detailed microstructural and fabric analysis, as well as the quartz, sillimanite and garnet fabric studies of the sheared rocks from the massifs demonstrate the dominant roles of three deformation episodes during Cenozoic tectonic evolution in the shear zone. Among the contrasting structural and microstructural associations in the shear zone, D2 structures, which were formed at the brittle to ductile transition during large-scale left-lateral shearing in the second deformation episode, predominate over the structural styles of the other two deformation episodes. Discrete micro-shear zones with intensive grain size reduction compose the characteristic structural style of D2 deformation. In addition, several types of folds (early shearing folds, F21, and late-shearing folds, F22) were formed in the sheared rocks, including discrete to distributed mylonitic foliation, stretching lineation and shear fabrics (e.g., mica fish, domino structures, as well as sigma and delta fabrics). A sequence of microstructures from syn-kinematic magmatic flow, high-temperature solid-state deformation, to brittle-ductile shearing is well-preserved in the syn-kinematic leucocratic intrusions. Deformation structures from the first episode (D1) are characterized by F1 folds and distributed foliations (S1) in rocks due to pure shearing at high temperatures. They are preserved in weakly sheared (D2) rocks along the eastern margin of the ALS belt or in certain low-strain tectonic enclaves within the shear zone. Furthermore, semi-brittle deformation structures, such as hot striae and discrete retrogression zones, are attributed to normal-slip shearing in the third deformation episode (D3), which was probably locally active, along the eastern flank of the DCS range, for example.There are four quartz c-axis fabric patterns in the mylonitic rocks, including type A point maxima, type B Y point maxima with crossed girdles superimposition, type C quadrant maxima, as well as type D point and quadrant maxima combination. They are consistent with microscopic observations of microstructures of high-temperature pure shearing, low-temperature simple shearing and their superimposition. Integrated microstructural analysis and fabric thermometer studies provide information on both high temperature (up to 750 °C) and dominant low-temperature (300-600 °C) deformations of quartz grains in different rock types. Sillimanite and garnet fabrics, especially the latter, were primarily formed at the peak metamorphism during high-temperature pure shearing.The above structural, microstructural and fabric associations were generated in the tectonic framework of the Indian-Eurasian collision. The low-temperature microstructures and fabrics are attributed to left-lateral shearing along the ASRR shear zone from 27 to 21 Ma during the southeastward extrusion of the Indochina block, which postdated high-temperature deformation at the peak metamorphism during the collision.

Liu, Junlai; Tang, Yuan; Tran, My-Dung; Cao, Shuyun; Zhao, Li; Zhang, Zhaochong; Zhao, Zhidan; Chen, Wen




Microsoft Academic Search

SUMMARY Background: Depression is the most frequent mental disorder in the world; its overall prevalence is about 8-12%. In Mexico, it has been calculated that 8.3% of the population aged 18-64 years has suffered this disorder along their lifetime. Disregarding country or culture, depression is two to three times more frequent in women than in men, more usual among separated

Jaime López Rodríguez; Marco Antonio; López Butrón; Blanca Estela; Vargas Terrez; Valerio Villamil Salcedo



Proteins that fuse and fragment mitochondria in apoptosis: con-fissing a deadly con-fusion?  


During apoptosis, mitochondria undergo multiple changes that culminate in the release of cytochrome c and other proapoptotic cofactors. Recently, a role for previously overlooked morphological changes, fission of the mitochondrial reticulum and remodeling of mitochondrial cristae, has been suggested in mammalian cells and in developmental apoptosis of C. elegans. Mitochondrial morphology is determined by fusion and fission processes, controlled by a growing set of "mitochondria-shaping" proteins, whose levels and function appear to regulate the mitochondrial pathways of cell death. Expression of pro-fusion proteins, as well as of inhibition of pro-fission molecules reduces apoptosis, suggesting a linear relationship between fragmentation and death. Mechanisms by which mitochondrial fragmentation promotes apoptosis and interactions between fragmentation and remodeling of the inner membrane are largely unclear. A tempting, unifying hypothesis suggests that fission is coupled to cristae remodeling to maximize cytochrome c release. PMID:16167173

Scorrano, Luca



Humectación del nylon 6.6 con tensioactivo aniónico con no-iónico y su mezcla  

Microsoft Academic Search

Dans la pratique, l’humectation est liée à\\u000al’angle de contact en équilibre du liquide (phase fluide) sur le solide (matière textile). Quand cette humectation est dynamique et que le solide se présente sous forme de fibre ou de mono-filament et, par conséquent, avec une incurvation de la\\u000asurface à humecter, il est difficile d’obtenir l’angle de contact, compte tenu de

Francisco Javier Carrión Fité



Pro and Con Discussion--Should Congress Curtail the Use of "Busing" for School Desegregation? Con  

ERIC Educational Resources Information Center

Views of advocates of busing to achieve racial desegregation in public schools are presented, including those of the U.S. Commission on Civil Rights, the NAACP, the American Civil Liberties Union, and the Joint Washington Office for Social Concern. (SF)

Congressional Digest, 1974




Microsoft Academic Search

SUMMARY In this study, the term children with special needs is used to refer to children who comprise a population at risk for various medical and psychological disorders. Studies of parenting practices compare families with children with special needs not sharing a specific disability to parents of average children. Moreover, studies usually compare white middle class mother-child pairs. It is

Marysela Díaz Romero; Edith Bolívar Reyna; Norma García Arellano




Microsoft Academic Search

Attention Deficit\\/Hyperactivity Disorder (ADD\\/ADHD) is a neuropsychiatric condition very common in the infantile population. It characterizes for the inattention presence and impulsivity and can be presented with or without hyperactivity in diverse degrees; it affects the academic achievement from each 7 to 10 patients, with a frequent comorbility dysfunctional behavior like: the Oppositional Defiant Disorder, Conduct Disorder, Learning Disabilities, Depression

María Elena; Navarro Calvillo


Comment on the paper "Synthesis, growth, structural, spectral, thermal, chemical etching, linear and nonlinear optical and mechanical studies of an organic single crystal 4-Chloro 4-Nitrostilbene (CONS): A potential NLO material" by P.M. Dinakaran, S. Kalainathan [Spectrochim. Acta A 111 (2013) 123-130].  


We argue that (trans)-4-chloro-4'-nitrostilbene is not a new organic nonlinear optical material as claimed by Dinakaran and Kalainathan [P.M. Dinakaran, S. Kalainathan, Synthesis, growth, structural, spectral, thermal, chemical etching, linear and nonlinear optical and mechanical studies of an organic single crystal 4-Chloro 4-Nitrostilbene (CONS): a potential NLO material, Spectrochim. Acta A 111 (2013) 123-130], but instead a well-known compound whose synthesis, spectral data, single crystal structure and second harmonic generation (SHG) efficiency are well documented in the literature. The title paper is completely erroneous. PMID:24152596

Srinivasan, Bikshandarkoil R; Dhuri, Sunder N; Nadkarni, V S



An Interim Pricing Strategy for ConRail, February, 1975.  

National Technical Information Service (NTIS)

The study analyses the merits for the various types of short term price increases in terms of general rate increases, commodity increases, terminal surcharges, and region surcharges. An estimate of the traffic diversion under each arrangement is presented...



MichCon upgrades SCADA to meet new requirements  

SciTech Connect

This paper reviews the decision making process used by Michigan Consolidated Gas Company to upgrade the company`s supervisory control and data acquisition (SCADA) system. The original system was reviewed for performance with the results showing problems with data storage and transmission capacity, out-dated proprietary hardware and software, and the lack of expandability. The paper goes on to provide a detail of the new system and its interconnection options. It reviews the new applications associated with system control and monitoring of the gas distribution system. It also reviews network and emergency control options.

Moir, K. [Michigan Consolidated Gas Co., Detroit, MI (United States); Derviller, P. [Valmet Automation, Calgary, Alberta (Canada)



The pros and cons of evidence-based surgery  

Microsoft Academic Search

Introduction: Evidence-based medicine (EBM) has been proposed as a new paradigm of practising medicine. However, an unproductive polarisation\\u000a between supporters and opponents can make its unbiased assessment difficult. This review gives an overview of the arguments\\u000a and discusses their surgeon-specific importance. Discussion: As EBM claims a position in the centre of medicine, it borders with other highly debated topics as,

Stefan Sauerland; Rolf Lefering; Edmund A. M. Neugebauer



The pros and cons of polyethylene sterilization with gamma irradiation.  


This retrospective study evaluated the implant, patient and surgical factors associated with polyethylene wear for one type of porous-coated hemispheric total hip arthroplasty cup. Radiographic wear measurements among 567 Duraloc cups (512 patients) revealed that liners sterilized by gamma-irradiation wore 0.085 mm/year less than those that were sterilized by gas-plasma, a noncross-linking chemical surface treatment. The substantially decreased wear rate associated with gamma-irradiation was attributed to sterilization-induced polyethylene cross-linking. Shelf-aging adversely affected liners that were gamma irradiated in air. On average, highly crystalline Hylamer liners showed a 0.064 mm/year increase in wear rates for each year of shelf storage after terminal sterilization with gamma-irradiation in air. Among conventional Enduron liners, the effect of shelf aging after gamma-irradiation in air was more modest, increasing wear rates by 0.014 mm/year for each year of shelf storage. Because Hylamer's wear performance degraded at about five times the rate of Enduron's, the improved wear resistance associated with gamma-irradiation in air would be lost after 1.3 years of shelf aging for Hylamer compared with 6.1 years for Enduron. For every additional year of age at the time of surgery, the wear rate decreased by 0.003 mm/year. Increased body mass index, a preoperative diagnosis of inflammatory arthritis, and a ceramic femoral head also were associated with decreased wear rates. PMID:15577466

Hopper, Robert H; Engh, C Anderson; Fowlkes, LaTonya B; Engh, Charles A



Perforación corneal no traumática estéril tratada con Tachosil ®  

Microsoft Academic Search

Case reportAn 83 year-old male reported to the emergency room with red eye and ocular pain. The slit-lamp examination showed a central corneal perforation of 1mm in diameter, with no associated infection or inflammatory process. The patient had no history of trauma. It was decided to apply a patch of Tachosil® at the site of corneal perforation. After 36hours of

R. Cañones-Zafra; J. Benítez-Herreros; K. Kubiak; M. A. Montes-Mollón; R. Jiménez-Parras



Re(con)ceiving young children's curricular performativity  

Microsoft Academic Search

Working (with) Deleuzo?Guattarian philosophical imaginaries opens (to) a multiplicity of possibilities for thinking differently about curriculum, young children and how they perform their curricular understandings. In this article I work (as) rhizome, bringing the imaginaries becoming and milieu into an early childhood curriculum conversation towards perturbing conventional, entrenched developmental understandings of young children and their learning. It is within\\/in multiplicitous

Marg Sellers



Pros and cons of stem cell transplantation for autoimmune disease.  


The data and discussion at this symposium have provided a most useful analysis of the autoimmune diseases and their potential for therapy by stem cell transplantation. These diseases are characterized by threat to life and particularly by chronic, painful and debilitating courses that warrant aggressive therapy. Selection of patients will be difficult because of the variable disease course and the necessity to choose patients who still have reversible disease. The safety of both autologous and allogeneic stem cell grafting has progressed to the point where, in many cases, the risks of the disease far outweigh those of transplantation. In my opinion the data presented at this symposium show that we should proceed cautiously with both autologous and allogeneic stem cell grafts. Purified stem cells, which have the advantage of being free of lymphocytes, should be used for the first series of autologous studies. These studies are attractive because of the low risk of transplant related complications but are less likely to be curative. Allogeneic grafts from perfectly matched donors have the advantage of providing a completely new immunological environment. For this reason, I believe that curative results are most probable after allogeneic stem cell engraftment. Emphasis should be on the identification of patients with HLA matched siblings. Initially, these studies will be carried out in patients with advanced disease, as was the case in the early days of transplantation for leukemia. In considering more aggressive treatment for autoimmune diseases it appears there are 3 possible approaches. First, and most conservative, is to store peripheral blood stem cells for possible future marrow rescue and then to give higher doses of immunosuppressive agents, especially in combination, to see whether there is an improvement over conventional doses. Second, for those who prefer a conservative approach to stem cell transplantation, is to give myeloablative and lymphoablative chemotherapy followed by purified (lymphocyte-free) hematopoietic stem cells. Third, and most likely to be curative, is myeloablative and lymphoablative therapy followed by stem cells from an HLA matched family member with subsequent short methotrexate and cyclosporine treatment to control GVHD. As we have heard, there are differences of opinion about whether the preparative regimen should include irradiation. It should be pointed out that total body irradiation is the most effective way to destroy lymphoid cells throughout the body. Careful monitoring of accumulating clinical results will pilot future investigation. PMID:9150129

Thomas, E D



[Hematopoietic stem cell transplantation in autoimmune diseases. Pros and cons  


New therapeutics have clearly advanced our chances of inducing remission in several aggressive autoimmune diseases like rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). Despite this, subgroups of patients with RA or SLE or of other diseases like systemic sclerosis (SSc) or multiple sclerosis (MS) still present a poor response to conventional drugs. In this kind of patients, haematopoietic stem cell transplantation (HSCT) provided important clinical benefits in several studies. This might depend upon several possible mechanisms such as purging of autoreactive T cells during conditioning or changes of the TH1/TH2 biological milieu. An overview of the results obtained so far, the drawbacks and the perspectives in this field are presented. PMID:12461572

Ferraccioli, G. F.



Umbilical cord blood transplantation: pros, cons and beyond.  


Large body of clinical and scientific data has been generated since the first cord blood transplantation (CBT) was performed in 1989. Superior immune plasticity of CB grafts, that allows for less stringent HLA matching, is especially valuable in the face of a persistently growing need for unrelated donor (UD) transplants. Limited cell dose remains the main setback of CBT, particularly in adult population. New strategies, such as transplantation with two cord blood units or using non-myeloablative conditioning, have remarkably expanded the availability of CB transplants in adults with hematological malignancies. Clinical trials with in vitro expanded CB-derived stem cells are under way. Currently cord blood is considered a second best choice after matched bone marrow. However, results of recent international studies indicate that in particular clinical settings, such as in children with leukemia, CB may become a frontline hematopoietic stem cell (HSC) source for transplantation. Recent advances in understanding the unique biology of cord blood will further expand indications for its use in different settings, including those beyond hematopoietic stem cells transplantation (HSCT). PMID:19282073

Stanevsky, Anfisa; Goldstein, Gal; Nagler, Arnon



9 CFR 319.301 - Chili con carne with beans.  

Code of Federal Regulations, 2013 CFR

...Mechanically Separated (Species) may be used in accordance with § 319.6. Head meat, cheek meat, or heart meat exclusive of the heart cap may be used to the extent of 25 percent of the meat ingredients, and its presence shall be...



Pros and Cons of the Acceleration Scheme (NF-IDS)  

Microsoft Academic Search

The overall goal of the acceleration systems: large acceptance acceleration to 25 GeV and beam shaping can be accomplished by various fixed field accelerators at different stages. They involve three superconducting linacs: a single pass linear Pre-accelerator followed by a pair of multi-pass Recirculating Linear Accelerators (RLA) and finally a nonâ scaling FFAG ring. The present baseline acceleration scenario has

Alex Bogacz; Slawomir Bogacz



Mucormicosis rinocerebral: Sobrevida en un niño con leucemia  

Microsoft Academic Search

A four year old child with acute lymphoblastic leukemia and severe neutropenia secondary to chemotherapy, presented with periorbitarian cellulitis and proptosis of the right eye. Initially it was supposed to have a bacterial origin but he didn't improve with antibiotic treatment. As MRI detected a cerebritis focus, three surgical drainages and debridements were done and a nasal osseus biopsy confirmed



Los Ácidos Grasos Trans Ahora Serán Listados Junto con las ...  

Center for Food Safety and Applied Nutrition (CFSAN)

... Qué es un Ácido Graso Trans? ¿Dónde se encuentran los ácidos grasos trans? ... Seleccione un producto para una respuesta! ... More results from


The Pros and Cons of Performance-Based Compensation.  

ERIC Educational Resources Information Center

|This paper analyzes the current and historical criticism of performance-based compensation in K-12 education. It claims that new compensation methods are feasible and are necessary in order to attract and retain the best and the brightest into the teaching profession. The document outlines the objections to performance-based compensation, which…

Solmon, Lewis C.; Podgursky, Michael


Asociación de linfomas malignos con herpes virus I y II  

Microsoft Academic Search

SUMMARY Objectives: To know the prevalence of seropositivity for herpes virus I and II in patients with malignant non Hodgkin lymphoma (NHL), and the association with the cell lineage (B or T). Patients and Methods: We considered 60 new or in first recurrence patients with NHL at the Hospital Nacional Guillermo Almenara from August 1999 to December 2000. We analyzed




Tratamiento de linfomas cutáneos de células T con bexaroteno  

Microsoft Academic Search

IntroductionThe choice of treatment in cutaneous T-cell lymphomas (CTCLs) depends on the clinical stage of the disease and the patient's general condition. To date, there is no curative treatment for this disease, and the objective is to control the symptoms and prevent the disease from progressing. Bexarotene is an X receptor-specific retinoid with anti-tumor activity. Its use as treatment for

Olatz Lasa; Rosa Izu; Elvira Acebo; Patricia Eguino; José L. Díaz-Pérez




Microsoft Academic Search

The microalga Chlorella growing in the efluentes of the fishing industry, has been using with the porpuse of trating polluted waters. When it is separated with centrifugation, the clarified remainder diminishes the Biochemical Oxygen Demand (BOD) until levels of 95%. Another way of separating the algae is with chitosana (deacetylated chitin) obtained from chitina (ß-N- acetyl-D-glucosamine), product that was proven

Cristina Ferrán G


Screening MR imaging versus screening ultrasound: pros and cons.  


Data support greater sensitivity of MR imaging compared with mammography and ultrasound in high-risk populations, in particular BRCA 1 and BRCA 2 carriers. Screening ultrasound improves cancer yield versus mammography alone in high-risk patients and in patients with dense breasts and is less expensive. Drawbacks include low positive predictive value, operator dependence, and significant physician time expenditure. Advances, such as refinement of automated whole-breast ultrasound, new outcomes data from ultrasound-detected masses in BI-RADS 3 and 4a categories, and development of new MR imaging sequences that allow rapid screening, potentially without use of contrast, will likely reveal the most appropriate tool over time. PMID:23928240

Mahoney, Mary C; Newell, Mary S



Fuerza muscular máxima en atletas con discapacidad intelectual  

Microsoft Academic Search

The sports activity requires of the harmonic and fine movement, and development and maturity of central nervous system and muscle-skeletal system is very important. Children with Down syndrome seen to love sports and can be very competitive, the performance were influenced for the neurological damage and reflect in the muscular activity. In the Down’ syndrome occur because the chromosomal abnormality

Carlos Alberto Morales Salas; Kalia Lavaut Sánchez; Rosa María Lam



The Pros and Cons of Life Without Parole  

Microsoft Academic Search

The question of how societies should respond to their most serious crimes if not with the death penalty is ‘perhaps the oldest of all the issues raised by the two-century struggle in western civilization to end the death penalty’ (Bedau, 1990: 481). In this article we draw attention to the rapid and extraordinary increase in the use of ‘life imprisonment

Catherine Appleton; Bent Grøver



Útero unicorne con cuerno rudimentario no comunicante en la adolescencia  

Microsoft Academic Search

Unicornuate uterus is a rare uterine anomaly resulting from the abnormal development of one of the Müllerian ducts. This abnormality usually manifests with dysmenorrhea, dyspareunia and pelvic pain appearing a few months after menarche, although there are late or even asymptomatic presentations. Clinicians should be aware of the importance of this rare congenital anomaly of the female genital tract, especially



Minimal database for the cutting parameters in con manufacturing systems  

Microsoft Academic Search

Selection of process parameters is an important problem faced by NC programmers and CAM operators. Tool wear, cutting force and power estimates are based on several models and require a large number of coefficients. This paper describes simplified models, an algorithm and a data structure to automatically determine the cutting parameters in turning. The aim is to minimize the number




Communication Technology: Pros and Cons of Constant Connection to Work  

ERIC Educational Resources Information Center

|We examined the relationship between employees' attitudes related to communication technology (CT) flexibility, communication technology (CT) use, work-to-life conflict and work satisfaction. Based on data obtained from 193 employees, CT flexibility predicted more CT use. Further, CT use was associated not only with increased work satisfaction,…

Diaz, Ismael; Chiaburu, Dan S.; Zimmerman, Ryan D.; Boswell, Wendy R.



Going Up? The Pros and Cons of Vertical Expansion.  

ERIC Educational Resources Information Center

|Describes the advantages and disadvantages of the vertical expansion of school buildings. Considers such factors as fire protection, compliance with the Americans with Disabilities Act, and cost. Discusses alternatives to vertical expansion. (PKP)|

Myler, Patricia A.; Boggs, Richard C.



Communication Technology: Pros and Cons of Constant Connection to Work  

ERIC Educational Resources Information Center

We examined the relationship between employees' attitudes related to communication technology (CT) flexibility, communication technology (CT) use, work-to-life conflict and work satisfaction. Based on data obtained from 193 employees, CT flexibility predicted more CT use. Further, CT use was associated not only with increased work satisfaction,…

Diaz, Ismael; Chiaburu, Dan S.; Zimmerman, Ryan D.; Boswell, Wendy R.



Indici di performance neuromotoria valutati con piattaforme robotiche: osservazioni preliminari  

Microsoft Academic Search

Introduzione Lo stroke causa circa 5 milioni di vittime l'anno nel mondo, ed è la prima causa di impairment motorio. Gli approcci riabilitativi attual- mente conosciuti consistono nel recupero motorio e funzionale della disabilità motoria conseguente l'episodio ictale. Recenti ricerche in neuroscienze hanno mostrato come la plasticità neuronale stimolata dall'attività motoria è alla base del recupero neurale post-ictale; per questo




Happiness on the Political Agenda? PROS and CONS  

Microsoft Academic Search

This paper provides a critical analysis of the application of happiness research into policy domains. An overview of the current\\u000a debate on the politics of happiness is elaborated by focusing on its promising perspectives as well as the potential problems\\u000a it raises. Arguments of proponents and opponents are confronted with each other in discussing the following central issues\\u000a in the

Valérie De Prycker



Pros and Cons of TQM for Student Affairs.  

ERIC Educational Resources Information Center

|Explores the key benefits and costs of implementing Total Quality Management (TQM) in student affairs. Discusses the experiences of early innovators and uses specific criteria to analyze TQM. Outlines effects on financial aid, costs, goal achievement, time and resource commitment, long-term focus, leaders as models, and clarity of mission. (RJM)|

Howard, Nancy Lee



Infección por VPH en mujeres con artritis reumatoide  

Microsoft Academic Search

Background: Human papillomavirus (HPV) is the main risk factor for the development of cervical cancer, which remains the most com- mon malignancy in our country. There are studies in which immunosuppressed patients have an increased risk of suffering an infection by HPV. Objective: To determine the prevalence of HPV infection in patients with rheumatoid arthritis (RA) compared with women matched

Diana E Flores Alvarado; Rocío Ortiz López; Mario Alberto; Garza Elizondo; Jacqueline Rodríguez Amado; Brenda R Vázquez Fuentes; Anajulia González Betancourt



Microsoft Academic Search

With new legislation on provision of interpreters in hospitals and courts being passed around the U.S., an increasing number of hospital and court administrators are seeing Telephone Interpreting (TI) as the solution to their communication problems with limited-English proficient citizens and immigrants. While the number of TI service providers grows and the use of TI spreads, TI has also become

Roberto A. Gracia-García


Moti e distanze angolari in cielo con telescopio e cronometro  

Microsoft Academic Search

A basic telescope and a chronometer can be used to learn classical methods of spherical astronomy. The conjunction Venus-Saturn of July 2, 2007 has been observed through July 3 with a 50 mm telescope. Planetary daily motions and angular distances with respect to Psi Leonis, have been obtained with telescope field of view crossing times with an accuracy of 1

Costantino Sigismondi




Microsoft Academic Search

The ethanol production in Colombia represents one of the more important economic lines, produced like antiseptic, reliable alcohol and additive for the gasoline. The porpuse of this work was of to increase the efficiency in the production of ethanol and to find a microorganism that represents an alternative in production, in front a Saccharomyces cerevisiaeit. Stocks of Zymomonas mobilisto var.

Adriana Matiz; Claudia Torres; Raúl A. Poutou



Broadening the DebateThe Pros and Cons of Globalization  

Microsoft Academic Search

Globalization has become an increasingly controversial topic, and the growing number of protests around the world has focused more attention on the basic assumptions of globalization and its effects. The purpose of this literature review is to broaden the boundaries of the debate on globalization and increase our understanding of its influence beyond the economic sphere. The winners and losers

Joyce S. Osland



Cervicogenic headache: the neck is a generator: con.  


Cervicogenic headache (CeH) is a well-recognized headache syndrome, distinguishable from other primary and secondary headaches. Although in some cases a cervical lesion may be detected in connection with the headache, many CeH patients have no demonstrable lesion. Besides, most of the frequent cervical diseases, such as spondylosis and disc herniations, do not present with headache of the cervicogenic type. This suggests that the neck is not an independent headache generator. CeH may depend in addition on a central predisposition counterpart, leading to the activation of the trigeminovascular system and pain generation. PMID:20456157

Vincent, Maurice B



Tratamiento de prúrigo nodular con ultravioleta B de banda estrecha  

Microsoft Academic Search

Summary Prurigo nodularis is an uncommon chronic skin condition characterized by multiple intensely itchy papules and nodules. Both the pruritus and the skin lesions are difficult to treat and are often refractory to many treatments. Local, intralesional and sistemic drugs, criosurgery and phototherapy have been employed, even in combination. Therapy of nodular prurigo with narrow band UVB phototherapy is a

Carolina Cantalejo Rodríguez; Ana María; Carrizosa Esquivel; Francisco Camacho Martínez



Microsoft Academic Search

The therapy for osteoporosis aims to reduce the incidence of fractures, which can be possible through the inhibition of the mechanism of bone reabsorption. Anyway, because the osteoclasts are not the only cells involved, the employment of an anabolic therapy, which can stmulate osteoblasts, seems to be interesting . Fluoride is annexed to the hydroxyapatite crystals and stimulates the bone

Giovanni Carlo Isaia; Federica Formoso; Stefania Di Bell


[Pros and cons of gonadectomy in female and male cats].  


Gonadectomy irreversibly prevents reproduction by removing germ cells as well as gonadal hormones. Moreover, consequences of gonadectomy include metabolic alterations influencing the incidence of diseases, phenotype and behavior. The desirable and undesirable effects of castration on different organ systems and their relation to timing of gonadectomy are discussed. For reasons of disease prevention as well as ease of husbandry and control of pet overpopulation prepuberal castration of non-breeding cats is recommended. At the time of gonadectomy the risk for developing obesity and associated diseases as well as dietary measures should be discussed with the owner. PMID:20533200

Reichler, I M



Hierro sacarosa intravenoso en el paciente con enfermedad renal crónica  

Microsoft Academic Search

We review the treatment of renal anemia with intravenous iron sucrose in predialysis, hemodialysis and peritoneal dialysis patients. The available evidence shows that intravenous iron sucrose is a highly effective treatment for iron-deficiency anemia in patients with renal disease.Moreover, intravenous iron sucrose is a cost-effective treatment because it reduces the required dosage of erythro-poiesis-stimulating agents. Intravenous iron sucrose is safe

Elena Donado; Marta Aguasca; Julen Ocharan-Corcuera; Iñaki Minguela; Isabel Gimeno; Alejandro Chena; Ramón Ruiz-De-Gauna




Technology Transfer Automated Retrieval System (TEKTRAN)

Wind power has been used to pump water for centuries; however, the development of the modern wind turbine has allowed for more applications for water pumping. This book, now available in Spanish, was written to give a complete overview of wind power water pumping and serves as a design guide for wa...


Encompassing Sexual Medicine within Psychiatry: Pros and Cons  

ERIC Educational Resources Information Center

|Objective: This article examines the positive and negative aspects of psychiatry encompassing sexual medicine within its purview. Methods: MEDLINE searches for the period between 1980 to the present were performed with the terms "psychiatry," "sexual medicine," and "sexual dysfunction." In addition, sexual medicine texts were reviewed for…

Segraves, Robert Taylor



Morbilidad y mortalidad neonatal asociadas con el síndrome de HELLP  

Microsoft Academic Search

Introduction: HELLP syndrome (HS) is a pregnancy complication with hemolysis, hepatic failure and thrombocytopenia. This syndrome increase maternal, fetus and neonatal morbidity and mortality. Objective: To compare clinical features, morbidity, mortality and hematological outcome in a group with and without HS. The variables were analyzed with tStudents, chi square, and Fisher test, p significative value was < 0.05. Results; We

Gerardo Flores Nava; Víctor Hugo; Jurado Hernández; Aurora Martínez Mondragón; Filiberto Rafael; Tenorio Marañón


The Pros and Cons of North American Monetary Integration  

Microsoft Academic Search

This study examines the major arguments for and against enhanced monetary integration in North America, with particular emphasis on the Canadian perspective. In this context, the question is whether the current floating rate regime should be replaced by greater fixity of exchange rates in relation to the U.S. dollar. While the choice among fixed rate systems is wide in priciple,

Sven W. Arndt



Autologous Transfusion – Pros and Cons from the Health Policy Perspective  

Microsoft Academic Search

SummaryAutologous blood transfusion plays a significant part in hemotherapy. This relates not only to the legal stipulations as established in the Transfusion Act and handed down through court decisions but is also true under therapeutic aspects where many meaningful approaches towards autologous procedures are being made. Over and beyond that, autologous blood is a contribution towards self-sufficiency in blood and

F. von Auer



Specialization in High School Sports. The Pros and Cons.  

ERIC Educational Resources Information Center

|Arguments for and against high school sport specialization, where student athletes limit their athletic participation to one sport which they practice, train for, and compete in for the entire school year, are presented. Discussed are: performance improvement, greater recognition, fewer injuries, burnout, less attention to other sports, increased…

Hill, Grant M.; Hansen, Gary F.



Aziende con allevamenti e imprese zootecniche nell'agricoltura italiana  

Microsoft Academic Search

This paper concerns the statistical presentation of the main structural and economic characteristics of the classi- cal livestock enterprises. As regards, a logical process has been followed starting from an analysis of UE and national frame- work regarding the total of the livestock holdings from the results of the farm structure surveys 2003 and 2005 carried out in compliance with

Andrea Brugnoli; Loredana De Gaetano


The Prose of Blogging (and a Few Cons, Too)  

ERIC Educational Resources Information Center

|"Blogging for the sake of blogging is fine, but what is the value added?" That's a question educational blogging advocates are now coming around to answer, and the value they're finding may seem preposterous to those who associate blogging with barely literate loudmouths and cyber predators. Can this often belligerent wasteland of poor…

Ramaswami, Rama



Neurofibromatosis y embarazo con resultado de muerte fetal: caso clínico  

Microsoft Academic Search

We present the case of a 24 week pregnant woman with neurofibromatosis (NF)-1 treated at our medical center with a result of fetal death in the 27th week of pregnancy. We review the literature on the reciprocal repercussions of NF and pregnancy and the potential health risks both for the mother and for the fetus. We also discuss preconceptional counseling,

Antonio Jesús Heredia Ruiz; José Andrés González Saavedra; M. Francisca Sánchez Martínez; M. Esther Vergara Maide; Juan Carlos Farfán Aguilar



[Pros and cons of chemical litholysis in bile duct calculi].  


Chemical litholysis of biliary stones is currently performed using monooctanoin (Mo) and methyl tert-butyl ether (MTBE). These two solvents dissolve cholesterol gallstones at different speeds due to their viscosity, high for Mo (47 cps) and low for MTBE (0.2 cps). A third compound was recently used which was produced by combining the previous two agents, Mo and MTBE, at a ratio of 2:1 v/v. The mixture has an intermediate viscosity (2.8 cps) and has shown good tolerability, management and efficacy with a 90% success rate in the treatment of post-surgical gallstones in 28 patients. PMID:2089282

Pozzi, C; Tritapepe, R


Pros and cons of the nonsurgical treatments for gallbladder stones.  


Dissolution of gallbladder stones is usually possible if the cholesterol content of the stones is high. Oral treatment with chenodiol or ursodiol is least invasive, but also least effective and slow. methyl tert-butyl ether requires delivery by percutaneous transhepatic catheter, but is rapidly effective. Extracorporeal shock wave lithotripsy enhances dissolution by oral bile acids, but is highly effective only for solitary stones less than or equal to 20 mm in diameter. Percutaneous cholecystostomy is most invasive, but effective regardless of stone composition. Stones will probably recur in 50 percent of patients with a patent cystic duct and intact gallbladder. PMID:2695446

Thistle, J L



ATC System Error and Appraisal of ConTROLLER Proficiency.  

National Technical Information Service (NTIS)

The report presents suggestions for the design of an air traffic control (ATC) incident-reporting system aimed at maximizing the amount of corrective feedback to the ATC system. The approach taken is system-oriented rather than controller-oriented. Includ...

W. F. O'Connor R. G. Pearson



A prototype for ovulation detection: pros and cons.  


A noninstrumented enzyme immunoassay for urinary estrone conjugates was adapted from an instrumented microtiter plate enzyme immunoassay assay. The end point of the assay was a color change from green to clear, which was visible to the unaided eye. The visible color change was adjusted to allow 80 ng/ml estrone conjugates (on the basis of a sample size of 6.5 microliters urine) to be distinguished from an infinite dilution without instrumentation. The evaluation of human urine collected from ovulatory ovarian cycles demonstrated that early follicular phase concentrations (35.9 +/- 6.8 to 79.4 +/- 14.7 ng/ml, n = 10) produced a dark-green color, whereas late follicular phase concentrations (162.9 +/- 20.1 ng/ml, n = 10) produced no color. Daily urine samples throughout 10 ovulatory ovarian cycles produced parallel profiles when compared to measurements of estradiol in paired blood samples. Complete analysis of the data indicated that ovarian follicular dynamics can be accurately monitored through the noninstrumented analysis of daily estrone conjugates in urine samples. PMID:1755459

Lasley, B L; Shideler, S E; Munro, C J



Fixed-dose combination therapy in hypertension: cons.  


The goal of antihypertensive therapy is to reduce the risk associated with blood pressure elevation. Although the choice of first-line drug therapy may exert some effects on different long-term cardiovascular endpoints, randomized clinical trials and meta-analyses demonstrated that blood pressure reduction per se is the primary determinant in primary and secondary prevention. Numerous analyses carried out over the last years have repeatedly shown that many patients require the combination of two or more drugs to reach the recommended level of blood pressure control. Within this context, combination therapy with separate agents or fixed-dose combination pills offers an attractive ability to lower blood pressure more quickly, decrease adverse effects and reach blood pressure target. It is not clear whether fixed combinations of antihypertensive agents in a single tablet provide a greater benefit than the corresponding components given separately. In other words, it is not clear if the use of fixed combinations translates into a clearly improved blood pressure control and cardiovascular prevention in clinical practice. Fixed-dose combinations may simplify the treatment regimen by reducing the number of pills and may be attractive for many hypertensive patients. However, single-pill (fixed) drug combinations have some disadvantages: (i) branded fixed combinations may be more expensive than equivalent free combinations; (ii) the duration of action of individual components may not be equivalent, and this may not justify a single daily dosing of the combination; and (iii) the use of fixed combinations implies less flexibility in modifying the doses of individual components and the exposure of patients to unnecessary therapy. Moreover, should a patient develop side effects to one component, the entire combination should be discontinued and replaced by free drugs. The following three types of fixed-dose tablets have been recently proposed to give additional flexibility: (i) tablet manufactured so that each of the two drugs is placed at opposite ends of the tablet with a drug-free (inactive) layer placed in between; (ii) tablet with the combination of drugs at each end with the inactive zone in between; and (iii) tablet divided into discrete, separate segments (the two drugs are combined uniformly), which provides benefits for initial close titration and dosage adjustments. Currently, none of the fixed-dose tablets available on the market have these characteristics and, consequently, are unable to be broken to allow sufficient flexibility. PMID:22867089

Angeli, Fabio; Reboldi, Gianpaolo; Mazzotta, Giovanni; Garofoli, Marta; Ramundo, Elisa; Poltronieri, Cristina; Verdecchia, Paolo



Re(con)ceiving Young Children's Curricular Performativity  

ERIC Educational Resources Information Center

|Working (with) Deleuzo-Guattarian philosophical imaginaries opens (to) a multiplicity of possibilities for thinking differently about curriculum, young children and how they perform their curricular understandings. In this article I work (as) rhizome, bringing the imaginaries "becoming" and "milieu" into an early childhood curriculum conversation…

Sellers, Marg



Primer contacto con una bomba de insulina. Caso clínico  

Microsoft Academic Search

Insulin pumps are devices that inject insulin continuously into the body in a similar way to the pancreatic secretion, and with endless possibilities to adjust schedules, meals and physical activities, giving diabetics the chance to lead a life with many less restraints due to their illness.Besides giving them this freedom, the therapy allows more precise control of blood glucose, significantly

Elena Gutiérrez-Torre; Ana Rosa Alconero-Camarero; Blanca Torres-Manrique; Elías Rodríguez-Martín



Interracial prison contact: the pros for (socially dominant) cons.  


Individuals high in social dominance orientation (SDO; Sidanius & Pratto, 1999) endorse group hierarchies and social inequality. Surprisingly little research has addressed contextual factors associated with reduced intergroup biases among such individuals. The present investigation considers a Person x Situation approach to this question in two British prisons, exploring the contextual factors outlined in the Contact Hypothesis (Allport, 1954). White inmates scoring higher in SDO exhibited significantly less in-group bias when reporting increased contact with Black inmates (Studies 1 & 2), when perceiving that favourable contact conditions are institutionally supported (Study 1), or when experiencing more pleasant personal interactions with Black inmates (Study 2). These SDO x Contact Condition moderation effects were mediated in Study 2: among high-SDO individuals, increased empathy towards Black inmates mediated the relation between contact variables and lower in-group bias. Implications for considering individual differences and empathy in contact settings are considered. PMID:17697448

Hodson, Gordon



Flexibilizing the Termination of the Employment Contract: Pros and Cons  

Microsoft Academic Search

The changes in the Romanian Labour Code appear to be a way of implementing the concept of flexicurity in our system of law. And among all institutions changed by the new law, probably the one related to termination of employment has the most dramatic effect within labour relations and the very application of the principle of workers’ protection. Indeed, after




Con: Can biomarkers be gold standards in Alzheimer's disease?  


As Alzheimer's disease remains a clinical diagnosis, and as clinical diagnosis can be difficult, it makes sense to look for so-called biomarkers. A biomarker predicts who is likely to have the illness and who is not. Some biomarkers might even correlate with a clinically meaningful response to treatment. Developing biomarkers is often characterized as searching for a diagnostic gold standard that can seem appealing in its promise of certainty. Even so, considering both the economic history of the gold standard and the results of neuropathological studies, framing the search for measurable, biological correlates of dementia syndromes in this way is likely to be self-defeating. Instead of considering biomarkers as providing certainty through referent criterion validation, currently it makes more sense to test their construct validity and their predictive ability. This means that while biomarkers should inform, they will not dictate clinical meaningfulness. For the foreseeable future, even were they to inform diagnosis, biomarkers cannot substitute for understanding whether patients and caregivers find a given dementia treatment effective. Instead, clinicians should recognize their own determining role, both in dementia diagnosis and in the evaluation of treatment. These roles will best be executed by hearing what patients and caregivers tell us about dementia, and its response to treatment. PMID:20587007

Rockwood, Kenneth



Con: Can biomarkers be gold standards in Alzheimer's disease?  

PubMed Central

As Alzheimer's disease remains a clinical diagnosis, and as clinical diagnosis can be difficult, it makes sense to look for so-called biomarkers. A biomarker predicts who is likely to have the illness and who is not. Some biomarkers might even correlate with a clinically meaningful response to treatment. Developing biomarkers is often characterized as searching for a diagnostic gold standard that can seem appealing in its promise of certainty. Even so, considering both the economic history of the gold standard and the results of neuropathological studies, framing the search for measurable, biological correlates of dementia syndromes in this way is likely to be self-defeating. Instead of considering biomarkers as providing certainty through referent criterion validation, currently it makes more sense to test their construct validity and their predictive ability. This means that while biomarkers should inform, they will not dictate clinical meaningfulness. For the foreseeable future, even were they to inform diagnosis, biomarkers cannot substitute for understanding whether patients and caregivers find a given dementia treatment effective. Instead, clinicians should recognize their own determining role, both in dementia diagnosis and in the evaluation of treatment. These roles will best be executed by hearing what patients and caregivers tell us about dementia, and its response to treatment.



The pros and cons of an oral treatment of dermatomycosis.  


The advantages and disadvantages of oral treatment of dermatomycosis is discussed, particularly with regard to griseofulvin and ketoconazole as examples. The advantages versus topical treatment are better efficacy, better compliance, and oral treatment is possibly more economical. Disadvantages are toxicity, development of resistant strains, interaction with other drugs and time- and cost consuming regular supervision of the patients. PMID:6098489

Fredriksson, T



La messa a fuoco automatica con FocusMax  

NASA Astrophysics Data System (ADS)

Let's know a bit better a method, among many others, of automatic focusing. The automation of one of the most critical phases of astro-imaging, requires the use of sophisticated hardware, such as the TCF-S focusers by Optec Inc. The presentation of FocusMax application was done by Lary Weber and Steve Brady at the 2001 Minor Planet Amateur/Professional Workshop, Tucson AZ. The software needs a standard ASCOM interface for obtaining the full automation.

Dho, Mario



Tratamiento oral con laquinimod en la esclerosis múltiple  

Microsoft Academic Search

IntroductionMultiple sclerosis (MS) is a chronic disease of the central nervous system, probably of autoimmune origin. Its early treatment with interferon beta or glatiramer acetate reduces the number of exacerbations, slows disability progression and improves the quality of life, but these treatments are only partially effective and require parenteral administration.

O. Fernández




Microsoft Academic Search

Modern consumers are interested in healthy food to ensure healthy ageing, with the aim of ensuring a healthy ageing. Research expects industry level achievement for fortified fruit as an alternative. This study assesses the useful life time cape gooseberry (Physalis peruviana L.) fortified with vitamin E using the technique of vacuum impregnation (IV), depending on the colour, texture and stability



?`Caos en la Resonancia 2:3 con Urano?  

NASA Astrophysics Data System (ADS)

The 2:3 resonace with Uranus and 3:2 with Neptune define limits in the semi -major axis interval, where some objects like 7066 Nessus (semi-major axis 24.456 au) has been observed. In this contribution, we describe the dynamics of a mass-less test particle near the critical value of the semi-major axis for each resonance. We analize the structure of the phase space in each case, using the restricted three-body planar approach, for different values of the Jacobi constant. Although this aproximation does not reflect the whole complexity of this region, it constitutes a good first solution, since there are not first or second order orbital resonances with the major planets. For the 2:3 resonance with Uranus, we find a smooth curve of quasi-periodical orbits surrounding the periodic orbit corresponding to the critical value of the semi-major axis. This region is also surrounded by chaotic orbits, probably due to the presence of other conmensurabilities of first or second order with Uranus. At the internal resonance 3:2 with Neptune, the structure of the section surfaces varies with the value of the C constant. In general, periodic orbits are found for the critical semi-major axis, but for other values of the Jacobi constant, which are obtained modifying the eccentricity of the particle orbit, the region is not closed anymore, so the test particle crosses the Neptune orbit, and escapes from this region.

Fernández, S.; Nicotra, M. A.


Learners or Participants? The Pros and Cons of "Lifelong Learning"  

ERIC Educational Resources Information Center

Whereas adult education used to be the preferred concept for those studying adult music-making, there is now an increasing trend away from this and towards lifelong learning. Uncritically adopting government lifelong learning discourses, however, blurs the line between educational ideals and political ones. Although there may be merit in the…

Mantie, Roger



Risk-Based Source Data Verification Approaches: Pros and Cons  

Microsoft Academic Search

The high cost of source data verification (SDV), particularly in large trials, has made it a target of scrutiny over the last decade. In addition, the positive impact (ie, cost-benefit ratio of SDV) on overall data quality is often questioned. As a result, regulators and industry groups have started looking at alternative SDV approaches. This article evaluates the FDA-supported risk-based

Vadim Tantsyura; Imogene Grimes; Jules Mitchel; Kaye Fendt; Sergiy Sirichenko; Joel Waters; Jim Crowe; Barbara Tardiff



Disnea en una paciente con lupus eritematoso sistémico  

Microsoft Academic Search

A 33-year-old woman with a previous history of systemic lupus erythematosus complained of exerptional dyspnea and pleuritic chest pain accompanied by polyarthritis. Chest-X-rays revealed an elevation of the right hemidiaphragm. We discuss the diagnostic and therapeutic approach.

Delia Taverner; José A. Gómez-Puerta



Intervenciones psicoterapéuticas en los pacientes con enfermedad médico-quirúrgica  

Microsoft Academic Search

More psychiatrists are in contact with medical and surgical patients with the recent development of Psychosomatic Medicine. Patients' emotional and behavioral reactions to medical illness are diverse. So are the different psychotherapeutic interventions used effectively on this patient population; however many have not been standardized. This article summarizes relevant findings in textbooks and peer-reviewed journal articles concerning basic concepts on

César H. González Caro; Henry Valencia Upegui; Sonia Bersh Toro



El cáncer entre las minorías con VIH y sida

Cancer and HIV/AIDS has always been “a tale of two diseases,” according to researchers at the NCI. Infection with HIV not only weakens the immune system, leading to AIDS and increasing the risk of opportunistic infections, but also increases the risk of several types of cancer. This Spanish-language Lifelines articles explains how HIV/AIDS affects cancer risk.


Early testing for Huntington disease in children: pros and cons.  


We report 2 young children who are examples of the consequences of premature testing for Huntington disease. Premature testing of a child or fetus carries complex medical and psychological issues to both the child and the family that need to be considered and explored more than in an adult with Huntington disease. We suggest that a child at risk for juvenile Huntington disease not be tested until symptoms are progressive and consistent with the disease and all other mimickers are excluded. When testing is indicated, a multidisciplinary approach is essential to educate the family about the risks and benefits of testing and improve their coping skills when the final diagnosis is made. PMID:19808987

Toufexis, Megan; Gieron-Korthals, Maria



Early Testing for Huntington Disease in Children: Pros and Cons  

Microsoft Academic Search

We report 2 young children who are examples of the consequences of premature testing for Huntington disease. Premature testing of a child or fetus carries complex medical and psychological issues to both the child and the family that need to be considered and explored more than in an adult with Huntington disease. We suggest that a child at risk for

Megan Toufexis; Maria Gieron-Korthals



Lupus eritematoso sistémico con mesenteritis retráctil y síndrome antifosfolípido catastrófico  

Microsoft Academic Search

The Antiphospholipid Syndrome coexisting with Lupus has been associated to wide variety of clinical manifestations, mostly linked to focal ischaemia or infarction. Acute multi-organ failure occurring in patients with these autoantibodies is named Catastrophic Antiphospholi- pid Syndrome because the high mortality. On the other hand, the term Retractile Mesenteritis is applied to the circumstance in which, an chro- nic inflammatory

A. Mera Varela; J. Blanco Rodríguez; S. Insua Vilariño; M. Camaño Freire



Role-based security: pros, cons, & some research directions  

Microsoft Academic Search

User role-based protection presents a flexible (hence adaptive) means for enforcing differing ranges of security policies. It can emulate both mandatory and discretionary access control modes of protection. Role-based protection enforces the principle of least privilege, hence minimizing the risk of Trojan horse attacks. This paper offers a glimpse into the strengths (and some weaknesses) of role-based protection, the structures

Matunda Nyanchama; Sylvia Osborn



Habilidad social y funcionamiento social en pacientes con esquizofrenia  

Microsoft Academic Search

The relations between Social Skill and Social Functioning were examined in a group of 100 schizophrenic patients. Social skill and Social functioning were assessed with The Simulated Social Interacction Test (SSIT) and the Social Functioning Scale (SFS) respectively. The results indicated that social skills were significantly related to social functioning of patients with schizophrenia. Two dimensions of the Social Functioning




Informal Commitments and Intervention in Ongoing Con?icts1  

Microsoft Academic Search

Abstract International relations scholars have devoted great efiorts to the analysis of the reliability of states’ formal commitments, especially in international agreements and during interna- tional crises. Less attention has been given to states’ informal commitments. Although we frequently observe decision-makers issue public, informal \\\\promises,\\

Renato Corbetta


Learners or Participants? The Pros and Cons of "Lifelong Learning"  

ERIC Educational Resources Information Center

|Whereas adult education used to be the preferred concept for those studying adult music-making, there is now an increasing trend away from this and towards lifelong learning. Uncritically adopting government lifelong learning discourses, however, blurs the line between educational ideals and political ones. Although there may be merit in the…

Mantie, Roger



Radiofrequency ablation of hepatocellular carcinoma: pros and cons.  


Among locoregional treatments for hepatocellular carcinoma (HCC), radiofrequency ablation (RFA) has been accepted as the most popular alternative to curative transplantation or resection, and it shows an excellent local tumor control rate and acceptable morbidity. The benefits of RFA have been universally validated by the practice guidelines of international societies of hepatology. The main advantages of RFA include 1) it is minimally invasive with acceptable morbidity, 2) it enables excellent local tumor control, 3) it has promising long-term survival, and 4) it is a multimodal approach. Based on these pros, RFA will play an important role in managing the patient with early HCC (smaller than 3 cm with fewer than four tumors). The main limitations of current RFA technology in hepatic ablation include 1) limitation of ablation volume, 2) technically infeasible in some tumors due to conspicuity and dangerous location, and 3) the heat-sink effect. Many technical approaches have been introduced to overcome those limitations, including a novel guiding modality, use of artificial fluid or air, and combined treatment strategies. RFA will continue to play a role as a representative ablative modality in the management of HCC, even in the era of targeted agents. PMID:21103289

Rhim, Hyunchul; Lim, Hyo K



A (Con)text for New Discourse as Semiotic Praxis  

ERIC Educational Resources Information Center

|Contemporary art requires that art and cultural educators reposition encounters with artefacts, images and performances into a context for new discourses. Whereas digital media and other aspects of visual popular culture predominate the frames of reference of school-age children, their context (codes) of reference, in large part, do not contain…

Fulkova, Marie; Tipton, Teresa M.



Educar ciudadanos críticos con los medios de comunicación  

Microsoft Academic Search

This paper reports the harmful effects of communication media when they are not cri- tically analysed and goes further trying to make justice in this sense. Besides this strong accusation, it offers an overcoming proposal for becoming aware and working to des- troy it. In order to exemplify his proposal, the author presents some reflections and analysis carried out in

Jesús Domingo Segovia



Pros and cons of peptide isolectric focusing in shotgun proteomics.  


In shotgun proteomics, protein mixtures are proteolytically digested before tandem mass spectrometry (MS/MS) analysis. Biological samples are generally characterized by a very high complexity, therefore a step of peptides fractionation before the MS analysis is essential. This passage reduces the sample complexity and increases its compatibility with the sampling performance of the instrument. Among all the existing approaches for peptide fractionation, isoelectric focusing has several peculiarities that are theoretically known but practically rarely exploited by the proteomics community. The main aim of this review is to draw the readers' attention to these unique qualities, which are not accessible with other common approaches, and that represent important tools to increase confidence in the identification of proteins and some post-translational modifications. The general characteristics of different methods to perform peptide isoelectric focusing with natural and artificial pH gradients, the existing instrumentation, and the informatics tools available for isoelectric point calculation are also critically described. Finally, we give some general conclusions on this strategy, underlying its principal limitations. PMID:23639126

Renato, Millioni; Cinzia, Franchin; Paolo, Tessari; Rita, Polati; Daniela, Cecconi; Giorgio, Arrigoni



Clinical drawbacks of total lymphoid irradiation: the cons  

SciTech Connect

Success has been reported with use of total lymphoid irradiation (TLI) in organ transplant recipients and in patients with rheumatoid arthritis and other autoimmune diseases. In a well-conducted randomized double blind clinical trial, Cook et al have found that TLI was superior to sham irradiation of patients with multiple sclerosis (MS). However, it is clear from looking at this data that not all patients responded to TLI and that with time disease activity returned. Our own experience with TLI in two MS patients was very disappointing. Despite its apparent benefit in some conditions, considerable drawbacks are associated with TLI. These include high financial cost, unpleasant treatment-related side effects, and the possibility that more serious morbidity as well as mortality may be treatment-related. Furthermore, the optimum therapeutic regimen for TLI has not yet been established. Issues related to cumulative dose, dose per fraction, frequency of fractions, field of irradiation, and interaction with other therapies still need clarification. For these reasons we do not recommend TLI as a treatment for MS.

Myers, L.W.; Ellison, G.W.; Fahey, J.L.; Tesler, A.; Gottlieb, M.S.



Early feeding after laparoscopic pyloromyotomy: the pros and cons  

Microsoft Academic Search

Background Early feeding after pyloromyotomy for hypertrophic pyloric stenosis (HPS) has been advocated because this would lead to earlier discharge. However, some authors remain reluctant to introduce early feeding because of concern about postoperative vomiting. This study aimed to clarify the effects of early versus later feeding after laparoscopic pyloromyotomy on postoperative vomiting, time required to reach full oral feeding,

J. D. W. van der Bilt; W. L. M. Kramer; D. C. van der Zee; N. M. A. Bax



Pros and Cons of Neoadjuvant Trials to Support Drug ...  

Center for Drug Evaluation (CDER)

Text Version... No taxane Tc qw for 12 weeks Ta q3w for 52 weeks 6-week washout Lb qd for 34 weeks HER2-positive early breast cancer (n=8000) ... More results from



Microsoft Academic Search

Optimization of the in vitro proliferation of jojoba (Simmondsia chinensis (Link) Schn.) by using rotable central composite design and inoculation with rhizobacteria Jojoba (Simmondsia chinensis (Link) Schn.) is a plant wich seeds produce oil of high commercial value used in cosmetology and as lubricant. Experiments were conducted using the rotable central composite design (RCCD) in order to get the optimum

Diana Andressen; Irene Manoochehri; Susana Carletti; Berta Llorente; Melángel Tacoronte; María Vielma



Microsoft Academic Search

The paper presents an experimental study aimed at investigating the efficiency of utilizing near- surface mounted (NSM) Glass Fiber Reinforced Polymer (GFRP) bars to strengthen unreinforced masonry (URM) walls and analyze it numerically with commercial finite element software. A series of 6 concrete masonry walls, unreinforced and\\/or strengthened with different strengthening schemes by GFRP bars, were subjected to a cyclic

Tong Li; Nestore Galati; Antonio Nanni


Uso de preservativo y número de parejas sexuales en hombres que tienen sexo con hombres con sífilis  

Microsoft Academic Search

Background and objectivesRecent years have seen a resurgence of syphilis in Spain due to changes in sexual behavior. Here we describe the incidence of the disease in our clinic and investigate its relationship with the sexual habits of men who have sex with men (MSM).

B. Repiso; M. Frieyro; F. Rivas-Ruiz; M. De Troya




Microsoft Academic Search

In this study was evaluated the corrosion resistance of nitrogen austenitic stainless steel, ASTM-F1586 and Böhler-P558, plasma-sprayed hydroxyapatite coating. The layers were characterized by SEM and DRX. The corrosion resistance was evaluated using tests of potential open circuit and cyclical polarization in Ringer solution to 37°C. The layers present lamelar morphology and pores. In the electrochemical tests was observed that



Prevalencia y factores asociados con infección por virus del papiloma humano cervical en pacientes con artritis reumatoide  

Microsoft Academic Search

Background: Nevertheless its association with cervicouterine cancer, there is no information about cervical human papillomavirus infection prevalence in patients with rheumatoid arthritis. Objective: To evaluate human papillomavirus infection prevalence through molecular biology tests, and to analyze this infection related factors in patients with rheumatoid arthritis. Material and method : Analytic, transversal study to 250 patients: 61 women with rheumatoid arthritis

Wendoline Rojo Contreras; Héctor Montoya Fuentes; Jorge I Gámez Nava; Ángel E Suárez Rincón; Jesús Vázquez Salcedo; Miguel Padilla Rosas; Luz M Baltazar Rodríguez; Xochitl Trujillo; Mario Ramírez Flores; Benjamín Trujillo Hernández; Laura González López


Prevalencia de disfunción eyaculatoria secundaria al tratamiento con alfa-bloqueantes en pacientes con hiperplasia benigna de próstata  

Microsoft Academic Search

PREVALENCE OF EJACULATORY DYSFUNCTION SECONDARY TO ALPHA-BLOCKER THERAPY IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA Introduction: Benign prostatic hyperplasia (BPH) is characterized by lower urinary tract symptoms (LUTS) that may cause ejaculatory disorders, although they could be also a consequence of alpha-blocker treatment. Objectives: To determine the prevalence of ejaculatory dysfunction in patients with HBP undergoing alpha-blocker therapy. Secondary objectives were

A. Martín-Morales; G. Meyer; E. Ramírez



Anemia refrattaria con eccesso di blasti (AREB) in paziente con artrite reumatoide in trattamento con methotrexate ed infliximab: descrizione di un caso clinico Case report: AREB in a patient with rheumatoid arthritis treated with methotrexate and infliximab  

Microsoft Academic Search

SUMMARY Anti TNF-? drugs seem to be the new frontier of Rheumatoid Arthritis (RA) therapy. The association infliximab methotrexate has been approved for the treatment of RA not responding to the classic therapy, but the short clinical experience in using antiTNF-? molecules brings to segnalation of new risks or adverse events. We describe a case of a patient, treated for

Giuseppe D'Alessandro; Maria Rosaria Bianco; Spiridion Politis; Celestino Ferrandina; Giuseppe Rossi; Emanuele Altomare


Prueba de inmunodifusión radial con hapteno nativo para diferenciar bovinos con revacunaciones repetidas con la cepa S19 de Brucella abortus Radial immunodiffusion test with native hapten in the differentiation of cattle with repeated Brucella abortus S19 strain revaccinations  

Microsoft Academic Search

The purpose of this study was to learn about the ability of radial immunodiffusion (RID) with a native hapten to differentiate vaccine-derived from infection-derived antibodies in cattle with repeated S19 strain revaccinations. The study was carried out in a dairy herd located in the state of Mexico, with experiencing abortions, placental retentions, stillbirths, and mummified fetuses. Heifer calves had been

Esperanza González Miranda; Laura Hernández Andrade; Efrén Díaz Aparicio


Efectos antidiabéticos de liposomas cargados con glibenclamida en ratas con diabetes inducida por alloxan Antidiabetic Activity of Glibenclamide Loaded Liposomes in Alloxan Induced Diabetic Rats  

Microsoft Academic Search

The antidiabetic activity of Glibenclamide loaded liposomes was investigated in model of alloxan-induced diabetes in rats. The blood glucose level was measured at 0 h and 1, 2, 4, 6, 8, 10, 12, 14 and 16h after the treatment. The alloxan - diabetic rats showed signifi cant reduction in blood glucose level, after treatment with Glibenclamide loaded liposomes and orally



Marcado general con tritio de la gentamicina C por intercambio catalitico con agua tritiada. (General Tritium labelling of gentamicin C by catalytic hydrogen exchange reaction with tritiated water).  

National Technical Information Service (NTIS)

Gentamicin C was labelled with tritium by means of a PtO(sub 2) catalyzed hydrogen exchange reaction. Under the conditions of the exchange (100 mg of gentamicin, basic form, 0,3 ml H(sub 2)O-(sup 3)H, and 50 mg of prereduced PtO(sub 2)) the radiochemical ...

C. Suarez D. Diaz



RoboCon: Operator interface for robotic applications. Final report: RoboCon electrical interfacing -- system architecture, and Interfacing NDDS and LabView  

SciTech Connect

The first appendix contains detailed specifications of the electrical interfacing employed in Robocon. This includes all electrical signals and power requirement descriptions up to and including the interface entry points for external robots and systems. The reader is first presented with an overview of the overall Robocon electrical system, followed by sub-sections describing each module in detail. The appendices contain listings of power requirements and the electrical connectors and cables used, followed by an overall electrical system diagram. Custom electronics employed are also described. The Network Data Delivery Service (NDDS) is a real-time dissemination communications architecture which allows nodes on a network to publish data and subscribe to data published by other nodes while remaining anonymous. The second appendix explains how to facilitate a seamless interface between NDDS and LabView and provides sample source code used to implement an NDDS consumer which writes a string to a socket.

Schempf, H.



Coste-efectividad de exenatida en comparación con insulina glargina en pacientes con obesidad y diabetes mellitus tipo 2 en España  

Microsoft Academic Search

Background and objectivesExenatide, a GLP-1 receptor agonist for adjuvant treatment of type 2 diabetes mellitus (T2DM), has been shown to be as effective as insulin glargine (IG) for reducing glycated hemoglobin levels combined with metformin or\\/and sulphonylureas. Exenatide is associated to weight reduction and a higher incidence of gastrointestinal adverse events.The objective of this study was to assess the cost-effectiveness

Gordon Goodall; María Costi; Louise Timlin; Jesús Reviriego; José Antonio Sacristán; Jayne Smith-Palmer; Tatiana Dilla



Valutazione ultrasonografica della risposta al trattamento con Etanercept in pazienti con artrite reumatoide* Ultrasonographic assessment of the response to Etanercept treatment in patients with rheumatoid arthritis  

Microsoft Academic Search

SUMMARY Objectives: To evaluate, using musculoskeletal ultrasound (MSUS), the effects of Etanercept therapy in patients with rheumatoid arthritis (RA) over 3 months of treatment. Methods: Eighteen consecutive patients, 3 male and 15 female, affected by RA (ACR criteria) who were non-respon- ders or partial responders to DMARDs therapy were commenced on Etanercept treatment. MSUS was performed bi- laterally in the

A. Iagnocco; C. Perella; F. Ceccarelli; E. Tripodo; C. Alessandri; L. Magrini; G. Valesini


Risk perception, risk management and vulnerability to landslides in the hill slopes in the city of La Paz, Bolivia. A preliminary statement.  


The article begins by describing the difficult living conditions of many people in the hill slopes (laderas) of La Paz, Bolivia, demonstrating that they are exposed to a combination of natural and social hazards. It shows that residents, community leaders and city planners tend to underestimate or deny risk, with important consequences for risk management, such as a failure to raise risk awareness. The article then proposes some hypotheses to explain risk perceptions in La Paz, discarding the usual single-approach interpretations and suggesting instead more nuanced theoretical explanations to account for why people build their homes in such hazardous environments. PMID:18958908

Nathan, Fabien



Flebótomos (Diptera: Psychodidae) del departamento de Guaviare, Colombia, con nuevos registros para el país  

Microsoft Academic Search

Introduction. Although cases of leishmaniasis have been reported in the province of Guaviare, Colombia, no entomological studies were included to identify the Lutzomyia sand fly vector species in that area. Objective. Lutzomyia species were identified from four townships of Guaviare. Probable vectors were named based on those species involved in transmission in other areas. Materials and methods. Sampling was undertaken

Olga Lucía Cabrera; Laureano Mosquera; Erika Santamaría; Cristina Ferro


El trastorno negativista de la personalidad y su relación con el abuso de sustancias  

Microsoft Academic Search

ObjectivesThe negativistic personality (NP), previously known as Passive-Aggressive Personality Disorder, is a matter of current discussion, due to several reasons: its current status (proposed to be studied in the DSM-IV), the critria that are proposed to define it, its similarity or proximity to other disorders and the diverse prevalence found in different populations. On the other hand, all studies estimate

E. J. Pedrero Pérez; A. López-Durán; A. Olivar Arroyo



Factores relacionados con una estancia media hospitalaria prolongada en la neumonia adquirida en la comunidad  

Microsoft Academic Search

Introduction: The length of hospital stay in patients with community-acquired pneumonia (CAP) varies considerably, even though this factor has a great impact on the cost of care for this condition. The objective of this study was to identify factors associated with prolonged hospitalization in these patients (48 days). Methods: Observational analysis of a prospective cohort of nonimmunosuppressed adults with CAP

Carolina Garcia-Vidal; Jordi Carratalaa; Violeta Diaz; Jordi Dorca; Ricard Verdaguer; Frederic Manresa; Francesc Gudiol


Breast augmentation with round, smooth saline or gel implants: the pros and cons.  


Breast augmentation is a procedure that can be performed successfully in many different ways. Large series are reported routinely, with greater than 95% patient satisfaction. It is clear that this is a procedure that has greatly benefited women and thereby society in general. It is inappropriate to be too dogmatic about each individual's technique, because many different techniques have achieved a high degree of success in terms of patient satisfaction and final results. That is not to say, however, that surgeons still are not plagued by the two most common downsides to this operation: capsular contracture and implant leakage. Certainly, strides have been made in the cause of prevention of capsular contracture in the past 20 years of the author's association with plastic surgery, but the author's opinion is that research has been hampered by the Food and Drug Administration's overprotection of women. There is no doubt that progress toward solving these two problems has been slowed by the current implant environment. Despite these handicaps, however, plastic surgery has continued to improve this procedure and now is delivering a successful and reproducible surgery using the saline implant. Most surgeons doubted this in the early 1990s, however. Plastic surgeons must continue to strive for improvements that serve patients and themselves in this new century. PMID:11471958

Elliott, L F



Breast augmentation with reduced-height anatomic implants: the pros and cons.  


The reduced-height anatomic saline-filled implant has certain advantages. It has a distinct footprint and profile that allows the creation of a breast with relatively exaggerated width and abbreviated height. This creation suits certain anatomic situations and often is preferred by women seeking a more natural-looking augmentation, without excessive upper pole fullness. The use of any anatomic design implant requires some dimensional planning and more precise pocket dissection. Although the risk for rotational deformities could be expected to be increased, clinically significant rotational deformities have not been a major problem. PMID:11471961

Spear, S L



Desarrollo rural con base en la innovación de las reformas organizativas de trabajo  

Microsoft Academic Search

Al observar desde el medio académico, la crisis tanto social como económica que atraviesa Colombia, sobre todo en su área rural, siendo los más afectados los campesinos, segmento de población inveteradamente menos favorecido por el Estado, es necesario presentar hoy propues- tas de solución a sus problemas y por allí mismo a los del país y sus regiones. Lo que

Juan Guillermo Correa Jaramillo; Fabio Antonio Calle Correa; Diego Alonso Moreno; Sergio Andrés Martínez Jiménez



The Establishment of Minority Affairs Offices in Schools of Dentistry: Pros and Cons.  

ERIC Educational Resources Information Center

Discusses the establishment of Minority Affairs Offices in dental schools, which follow the American Association of Medical Colleges' model as one method of addressing the declining enrollment and compounding oral health disparities of underrepresented minorities--African Americans, Hispanics, and Native Americans. (EV)

Ballard, Billy R.



Astronomía gamma con telescopios Cherenkov: hacia un observatorio astronómico abierto a la comunidad  

NASA Astrophysics Data System (ADS)

Gamma-ray astronomy is opening the way to a universe far more energetic than anyone could have imagined half a century ago. The understanding of the processes of nature which carry a large portion of the energy in the universe, has astrophysical and cosmological implications. The next gen- eration of Cherenkov telescopes, an order of magnitude more sensitive and with higher resolution than the current systems, will mean a significant step forward for ground-based gamma-ray astronomy. This paper presents the current status of this field as well as the next generation of telescopes in this energy range, which are being designed for the first international observa- tory open to the astronomical community. The Cherenkov Telescope Array project and the Argentine sites proposed for the southern observatory are described in this paper. FULL TEXT IN SPANISH

Rovero, A. C.


Microplanificacion: Un Proceso de Programacion y Desarrollo con Base en la Comunidad (Microplanning).  

National Technical Information Service (NTIS)

The book is a Spanish translation of a practical guide on urban, low-income settlements for community groups and their leaders. Microplanning is a community-based process in design and development which enables programs for neighborhood upgrading to be pr...

R. Goethert N. Hamdi S. Gray A. Slettebak



Transition metals in diamond: experimental and theoretical identification of Co-N complexes  

NASA Astrophysics Data System (ADS)

Diamonds grown using a cobalt/iron catalyst and annealed at 1800°C were studied using two experimental techniques. A zero-phonon line, observed in photoluminescence at 2.367eV, showed the splitting under uniaxial stress characteristic of an optical transition at a defect of trigonal symmetry. The same samples were measured by electron paramagnetic resonance (EPR) spectroscopy where they showed the defect labelled O4. This centre contains cobalt and possibly nitrogen, but has monoclinic symmetry. Ab initio modelling using the local density approach (LDA) with the code AIMPRO suggests that the optical transition is at a defect consisting of neighbouring substitutional cobalt and nitrogen atoms. A plausible model for the EPR data is a cobalt atom at the centre of a divacancy with a neighbouring nitrogen atom. We conclude that the defects giving rise to the 2.367eV photoluminescence and EPR O4 centres are both simple cobalt-nitrogen pairs.

Johnston, K.; Mainwood, A.; T. Collins, A.; Davies, G.; Twitchen, D.; Baker, J. M.; Newton, M.



Pro\\/con debate: Should antimicrobial stewardship programs be adopted universally in the intensive care unit?  

Microsoft Academic Search

ABSTRACT: You are director of a large multi-disciplinary ICU. You have recently read that hospital-wide antibiotic stewardship programs have the potential to improve the quality and safety of care, and to reduce the emergence of multi-drug resistant organisms and overall costs. You are considering starting one of these programs in your ICU, but are concerned about the associated infrastructure costs.

Philip George; Andrew M Morris



Policy Instruments in Integrating Biodiversity Cons ervation and Carbon Sequestration as a Part of Forest Management  

Microsoft Academic Search

Carbon sequestration and biodiversity conservation are both public goods that are under international governance. This paper outlines one p ossible policy instrument for the integration of carbon sequestration and biodiversity, which encour ages private forest owners to change their behaviour with respect to forest management. The id ea is that private forest owners are introduced by voluntary agreements on less

Anssi Ahtikoski; Eriika Melkas; Paula Horne; Kai Kokko


Reforzamiento interno del conducto radicular con cemento endodóntico de vidrio ionomérico  

Microsoft Academic Search

Restorative dentistry pursues, among other aims, to restore teeth anatomy and functionality affect- ed by a painful disease and\\/or iatrogenics, and to preserve the remaining tooth structure. Hence, having an overextended root canal at the coronal third, the practitioner should preserve tooth structure and re - inforce the internal root canal so that biomechanical properties may permit restoration. Materials used




Fermi Offline Software: The Pros and Cons of Reusing Free Software  

NASA Astrophysics Data System (ADS)

The Fermi Gamma-ray Observatory, including the Large Area Telescope (LAT), was launched June 11, 2008. We are a relatively small collaboration, with a maximum of 25 software developers in our heyday. Within the LAT collaboration we support Red Hat Linux, Windows, and are moving towards Mac OS as well for offline simulation, reconstruction and analysis tools. Early on it was decided to use one software system to run our simulations as well as ultimately handle the event processing for real data. We leveraged many existing HEP external libraries (Geant4, Gaudi Framework, ROOT, CLHEP, CMT) to ease the burden on our developers. This strategy of re-using existing software helped us pull together our system quickly and test during our beam tests and data challenges. Now, after launch, we are in a new phase of the project, where we must move forward to support modern operating systems and compilers to get us through the life of the mission. This means upgrading our external libraries as well, which are not under our direct control. Meanwhile, it is crucial to our production system that we carefully orchestrate all upgrades to insure stability. An additional hurtle is that our number of active developers has dwindled dramatically. Many of those left are Windows developers reliant on the Visual Studio development environment, while our user base and production system depend on our Linux distributions. There have been a number of lessons learned, with undoubtedly more to come.

Kelly, H.



Pros and cons of splenectomy in patients with myelofibrosis undergoing stem cell transplantation  

Microsoft Academic Search

During fetal development, the spleen is a major hemopoietic organ. In the adult human, this task is relinquished to the bone marrow. However, under the stress of certain pathologic conditions, extramedullary hemopoiesis may again occur in the spleen. This is especially true for diseases of the marrow, in particular, myeloproliferative disorders such as agnogenic myeloid metaplasia, which is associated with

Z Li; HJ Deeg



The pros and cons of human therapeutic cloning in the public debate.  


Few issues linked to genetic research have raised as much controversial debate as the use of somatic cell nuclear transfer technology to create embryos specifically for stem cell research. Whereas European countries unanimously agree that reproductive cloning should be prohibited there is no agreement to be found on whether or not research into therapeutic cloning should be permitted. Since the UK took the lead and voted in favour of regulations allowing therapeutic cloning the public debate has intensified on the Continent. This debate reflects the wide spectrum of diverse religious and secular moralities that are prevalent in modern multicultural European democratic societies. Arguments range from putting forward strictly utilitarian views that weight the moral issues involved against the potential benefits that embryonic stem cell research may harbour to considering the embryo as a human being, endowed with human dignity and human rights from the moment of its creation, concluding that its use for research is unethical and should be strictly prohibited. Given the current state of dissension among the various European states, it is difficult to predict whether 'non-harmonisation' will prevail or whether in the long run 'harmonisation' of legislation that will allow stem cell research will evolve in the EU. PMID:12126805

Nippert, Irmgard



Pros and cons of splenectomy in patients with myelofibrosis undergoing stem cell transplantation.  


During fetal development, the spleen is a major hemopoietic organ. In the adult human, this task is relinquished to the bone marrow. However, under the stress of certain pathologic conditions, extramedullary hemopoiesis may again occur in the spleen. This is especially true for diseases of the marrow, in particular, myeloproliferative disorders such as agnogenic myeloid metaplasia, which is associated with severe fibrosis of the marrow space. At the same time, the spleen sequesters blood cells and contributes to peripheral blood cytopenias, which may improve following splenectomy. However, success is unpredictable, and the operative mortality of splenectomy is on the order of 10%. As a growing number of patients undergo hemopoietic stem cell transplantation as definitive therapy for myelofibrosis, the decision on splenectomy has additional ramifications since the spleen plays an important role in the kinetics of engraftment of donor cells and in immune reconstitution. We conclude from our analysis of available information that the benefit of splenectomy is difficult to predict, although after transplantation splenectomized patients have faster hemopoietic recovery. It appears that the most important indication for splenectomy in these patients is the relief of symptoms from massive spleen enlargement. PMID:11237072

Li, Z; Deeg, H J



Trasplante celular y terapia regenerativa con células madre Cell transplant and regenerative therapy with stem cells  

Microsoft Academic Search

One of the fields of medicine that has raised the most expectations in recent years is cell therapy with stem cells. The isolation of human embryo cells, the apparent and unexpected potentiality of adult stem cells and the development of gene therapy lead us to imagine a hopeful future for a significant number of diseases that are at present incurable.

F. Prósper; J. J. Gavira; J. Herreros; G. Rábago; R. Luquin; J. Moreno; J. E. Robles



Madres adultas y madres adolescentes. Un análisis comparativo de las interacciones que mantienen con sus bebés  

Microsoft Academic Search

This work analyzes the differences in the interactions of a group of adolescent mothers and another one of adult mothers with their babies of 8-12 months of age during feeding time. In this way, we studied 93 mother-baby dyads (41 adolescents and 52 adults) in 4 observational dimensions: (1) the emotional warm; (2) maternal sensitivity; (3) linguistic development and autonomy



Will Broadband Networks Make the World Greener? Evaluating Pros and Cons of Broadband Development  

Microsoft Academic Search

The environmental issue has generally received much attention from the public for decades, especially as a result of heavy industry - electrical energy, oil and gas, mining, steel and metals. Recently, attention has been paid to Information and Communication Technology (ICT) and its effect on the knowledge and related industries. Broadband, both fixed and mobile, is not an exception. Even




The effect of earnings on housework: Pros and cons of HILDA's time use data items  

Microsoft Academic Search

The HILDA survey includes several 'stylised' time use data items. In time use research, such data are generally regarded to be of lower quality than diary data (for which respondents record each episode of time use over a given period, typically over one or two days). However, this limitation needs to be considered alongside the advantages of the survey, particularly

Peter Siminski



Emissions trading and competitiveness: pros and cons of relative and absolute schemes  

Microsoft Academic Search

Emissions trading is a hot issue. At national as well as supranational levels, proposals for introduction of emissions trading schemes have been made. This paper assesses alternative emissions trading schemes at domestic level: (1) schemes where the total level of emissions is fixed (absolute cap-and-trade), (2) schemes where the allowable level of emissions per firm is related to some firm-specific

Onno Kuik; Machiel Mulder




Microsoft Academic Search

I sistemi di monitoraggio dei fenomeni franosi richiedono, nella fase preliminare, la conoscenza del tipo di movimento in atto o potenzialmente possibile nell'area esaminata, in modo da poter selezionare il sistema più efficace; è quindi fondamentale conoscere le caratteristiche geologiche del sito d'interesse. La seconda fase consiste nell'installazione degli strumenti adatti e nell'esecuzione della misure di monitoraggio: queste ultime possono

L. Sambuelli; M. Mondin; S. Franchi; C. Strobbia; G. Lollino


Pros, cons of techniques used to calculate oil, gas finding costs  

Microsoft Academic Search

A major problem facing the U.S. petroleum industry is the higher average finding costs that now exist within the U.S. compared with the average finding costs outside the U.S. It has been argued that federal lands and offshore areas need to be open for drilling in order to reduce average finding costs in the U.S. This article analyzes the strengths

D. Gaddis; H. Brock; C. Boynton



Evidence of lightning and volcanic activity on Venus - Pro and con  

Microsoft Academic Search

It is argued that the impulsive 100-Hz noise bursts detected with the use of the electric field antenna on the Pioneer Venus Orbiter (PVO) have plasma wave charcteristics that can only be explained if they are whistler mode signals of a type that can be produced by atmospheric discharges. It is further argued that these data are evidence for lightning

F. L. Scarf; C. T. Russell



¿Existe diferencia entre extracción de catarata asociada con vitrectomía realizada vía córnea clara versus pars plana?  

Microsoft Academic Search

SUMMARY Objective: To determine if cataract extraction via pars plana or clear cornea plus vitrectromy causes different corneal damage degrees, and describe the complications. Design: Prospective, comparative, randomized study, including patients with vitreous hemorrhage secondary to diabetic retinopathy plus cataract. Patients were randomly assigned to be treated with lensectomy plus vitrectomy (group A), or clear cornea phacoemulsification plus vitrectomy (group

Jaime Villaseñor-Diez; Javier Zamarripa; Hugo Quiroz-Mercado


Heat-transfer and solidification model of continuous slab casting: CON1D  

Microsoft Academic Search

A simple, but comprehensive model of heat transfer and solidification of the continuous casting of steel slabs is described,\\u000a including phenomena in the mold and spray regions. The model includes a one-dimensional (1-D) transient finite-difference\\u000a calculation of heat conduction within the solidifying steel shell coupled with two-dimensional (2-D) steady-state heat conduction\\u000a within the mold wall. The model features a detailed

Ya Meng; Brian G. Thomas



Office folklore in the academic paperwork empire: The interstitial space of gendered (con)texts  

Microsoft Academic Search

“Office folklore,” the ubiquitous cartoons, parodies, and sayings photocopied, faxed, and displayed in millions of offices across the United States, is an expressive nexus of individual and organization, work and play, handicraft and technology. This feminist cultural critique locates office folklore in the interstices of organizational structure as cooperatively created spaces of hypochondriasis, resistance, and pleasure for organizational members who

Elizabeth Bell; Linda C. Forbes



Trattamento di una cisti follicolare con ritenzione di due incisivi in prossimità di un mesiodens  

Microsoft Academic Search

ObjectivesDental retention in healthy patients is caused by local factors such as supernumerary teeth, tumors, cysts or odontomas. The authors report a case of dental impaction due to a dentigerous cyst and a mesiodens.

D. A. Di Stefano; M. F. Valentino



Chemically triggered C-ON bond homolysis in alkoxyamines. 6. Effect of the counteranion.  


We showed (J. Org. Chem. 2012, 77, 9634) that the activation by methylation of pyridyl-based alkoxyamine 1 increased with the hydrogen bond donor properties of solvents. In this paper, activation of 1 by protonation with acids, CF3COOH and CSA, in tert-butylbenzene (t-BuPh) and in H2O/MeOH afforded, with CF3COOH, k(d) 28-fold larger in H2O/MeOH than in t-BuPh, whereas it was only 4-fold larger when CSA was used. This puzzling observation was ascribed to the dissociation of the intimate ion pair. PMID:23855482

Audran, Gérard; Brémond, Paul; Marque, Sylvain R A; Obame, Germain



Cardioprotection techniques: preconditioning, postconditioning and remote con-ditioning (basic science).  


Ischemic heart disease (IHD) is the leading cause of death and disability worldwide. The major pathological consequences of IHD arise from the detrimental effects of acute ischemia-reperfusion injury (IRI) on the myocardium. Therefore, in order to improve clinical outcomes in patients with IHD, novel therapeutic strategies are required to protect the myocardium from acute IRI and preserve cardiac function (cardioprotection). In this regard, endogenous cardioprotective strategies such as ischemic preconditioning (IPC), ischemic postconditioning (IPost) and remote ischemic conditioning (RIC) may provide novel approaches for protecting the heart in clinical settings in which the patient experiences acute myocardial IRI. In this review article, we provide an overview of these endogenous cardioprotective strategies with respect to the pre-clinical experimental literature, exploring their major characteristics and underlying signaling mechanisms. The application of these therapeutic strategies in the clinical setting for potential patient benefit is reviewed in another article in this special issue. PMID:23270554

Hausenloy, Derek J



Postmating transcriptional changes in reproductive tracts of con- and heterospecifically mated Drosophila mojavensis females  

PubMed Central

In internally fertilizing organisms, mating involves a series of highly coordinated molecular interactions between the sexes that occur within the female reproductive tract. In species where females mate multiply, traits involved in postcopulatory interactions are expected to evolve rapidly, potentially leading to postmating-prezygotic (PMPZ) reproductive isolation between diverging populations. Here, we investigate the postmating transcriptional response of the lower reproductive tract of Drosophila mojavensis females following copulation with either conspecific or heterospecific (Drosophila arizonae) males at three time points postmating. Relatively few genes (15 total) were differentially regulated in the female lower reproductive tract in response to conspecific mating. Heterospecifically mated females exhibited significant perturbations in the expression of the majority of these genes, and also down-regulated transcription of a number of others, including several involved in mitochondrial function. These striking regulatory differences indicate failed postcopulatory molecular interactions between the sexes consistent with the strong PMPZ isolation observed for this cross. We also report the transfer of male accessory-gland protein (Acp) transcripts from males to females during copulation, a finding with potentially broad implications for understanding postcopulatory molecular interactions between the sexes.

Bono, Jeremy M.; Matzkin, Luciano M.; Kelleher, Erin S.; Markow, Therese A.



Postmating transcriptional changes in reproductive tracts of con- and heterospecifically mated Drosophila mojavensis females.  


In internally fertilizing organisms, mating involves a series of highly coordinated molecular interactions between the sexes that occur within the female reproductive tract. In species where females mate multiply, traits involved in postcopulatory interactions are expected to evolve rapidly, potentially leading to postmating-prezygotic (PMPZ) reproductive isolation between diverging populations. Here, we investigate the postmating transcriptional response of the lower reproductive tract of Drosophila mojavensis females following copulation with either conspecific or heterospecific (Drosophila arizonae) males at three time points postmating. Relatively few genes (15 total) were differentially regulated in the female lower reproductive tract in response to conspecific mating. Heterospecifically mated females exhibited significant perturbations in the expression of the majority of these genes, and also down-regulated transcription of a number of others, including several involved in mitochondrial function. These striking regulatory differences indicate failed postcopulatory molecular interactions between the sexes consistent with the strong PMPZ isolation observed for this cross. We also report the transfer of male accessory-gland protein (Acp) transcripts from males to females during copulation, a finding with potentially broad implications for understanding postcopulatory molecular interactions between the sexes. PMID:21518862

Bono, Jeremy M; Matzkin, Luciano M; Kelleher, Erin S; Markow, Therese A



Revisiting adoption of high transmission PSM: pros, cons and path forward  

NASA Astrophysics Data System (ADS)

High transmission attenuated phase shift masks (Hi-T PSM) have been successfully applied in volume manufacturing for certain memory devices. Moreover, numerous studies have shown the potential benefits of Hi-T PSM for specific lithography applications. In this paper, the potential for extending Hi-T PSM to logic devices, is revisited with an emphasis on understanding layout, transmission, and manufacturing of Hi-T PSM versus traditional 6% embedded attenuated phase shift mask (EAPSM). Simulations on various layouts show Hi-T PSM has advantage over EAPSM in low duty cycle line patterns and high duty cycle space patterns. The overall process window can be enhanced when Hi- T PSM is combined with optimized optical proximity correction (OPC), sub-resolution assist features (SRAF), and source illumination. Therefore, Hi-T PSM may be a viable and lower cost alternative to other complex resolution enhancement technology (RET) approaches. Aerial image measurement system (AIMS) results on test masks, based on an inverse lithography technology (ILT) generated layout, confirm the simulation results. New advancement in high transmission blanks also make low topography Hi-T PSM a reality, which can minimize scattering effects in high NA lithography.

Ma, Z. Mark; McDonald, Steve; Progler, Chris



Cuidar de niños con necesidades especiales de salud: desafíos para las familias y la enfermería pediátrica  

Microsoft Academic Search

Children with special health care needs (CSHN) demand continuous and complex special health care at home. Qualitative research was applied to describe and discuss the challenges determined for these caring to CSHN's caregivers at home. Four female caregivers of the CSHN in a room-in at teaching hospital in the southern Brazil on December of 2004 were interviewed and participated in

Eliane Tatsch NevesI; Ivone Evangelista


Caso clínico: coordinación en los cuidados de una paciente con cáncer de mama  

Microsoft Academic Search

In Spain, cancer is the leading cause of death in absolute terms. Statistically, the most frequent type of cancer in women in developed countries is breast cancer, which is becoming the leading cause of death from cancer among women.The breast cancer is statistically the most frequent in women and it is getting the first reason of death by cancer between

M. del Carmen Peinado-Barraso; M. del Rosario Cabrerizo-Cordero; Ana Eva Granados-Matute; Raquel Contreras-Fariñas



Pro\\/con clinical debate: Are steroids useful in the management of patients with septic shock?  

Microsoft Academic Search

Decision-making in the intensive care unit is often very difficult. Although we are encouraged to make evidence-based decisions, this may be difficult for a number of reasons. To begin with, evidence may not exist to answer the clinical question. Second, when there is evidence it may not be applicable to the patient in question or the clinician may be reluctant

Frank V Ritacca; Carmine Simone; Randy Wax; Katherine G Craig; Keith R Walley




Microsoft Academic Search

Signalling with urine and excretion by captive wolves: criteria for identification and sexual differences In a study carried out during a year in captivity, with two reproductive pairs of Iberian wolf (Canis lupus signatus Cabrera, 1907), it was observed as the micturitions were made onto conspicuous and high substrates (trees and stones). For raised leg urination (a typical males posture)




Microsoft Academic Search

The aim of this paper was to review the current knowledge about comorbidity between personality disorders and eating disorders. Personality disorders implicate a poor prognosis in anorexia and bulimia nervosa. Cluster C personality disorders, particularly obsessive, avoidant and dependent personality disorders, are the most relevant in anorexia. However, in bulimia, an impulsive temperament and borderline personality seem to be the

Enrique Echeburúa; Izaskun Marañón


The Japanese Assistant Teacher Program in Western Australia: A Consideration of the Pros and Cons  

ERIC Educational Resources Information Center

|It is quite common for Australian schools introducing Japanese as a foreign language to engage native Japanese volunteers to assist in the classroom using a collaborative team-teaching approach. These volunteer Japanese assistant teachers, commonly referred to as Japanese Assistant Teachers (JATs), are an indispensable asset to school language…

Hasegawa, Hiroshi



Platica Directa Sobre Securidad Con Pistolas De Clavos (Straight Talk About Nail-Gun Safety).  

National Technical Information Service (NTIS)

This publication provides the following nail gun safety tips in a comic book format. Nail Gun Trigger Safety: (1) Removing the safety tip spring or disabling any safety device increases the risk of injury. OSHA prohibits doing these things. (2) Use the 's...



Perfilando a los estudiantes en relacion con la violencia (Profiling Students for Violence). ERIC Digest.  

ERIC Educational Resources Information Center

|This digest in Spanish discusses student profiling and describes strategies for reducing the risk of violence in schools. "Student profiling" refers to a process in which checklists of behaviors and personal characteristics associated with youth who have perpetrated violence are used to determine a student's potential for future violence. A…

Lumsden, Linda


Detección de la estrella simbiótica Hen 2-87 en rayos X con XMM-Newton  

NASA Astrophysics Data System (ADS)

Symbiotic stars are interacting binary systems, where accretion, most of the times, occurs onto a white dwarf. Until recently only a couple of dozens of symbiotics were known to be X-ray emitters, with most of the emission having energies of less than about 2.00 keV. In the last decade, with the launch of modern X-ray satellites such as XMM-Newton, Chandra and Swift, the number of known symbiotics with X-ray emission almost doubled. Here we present the detection of Hen 2-87 at soft X-rays energies (0.30-5.00 keV), a system that had not been previously detected at high energies. The X-ray emission is due to optically thin thermal emission, with no detectable variability on short time scales, suggesting that it is originated in a region where the winds from the white dwarf and the red giant collide. This new finding adds another member to the growing class of symbiotic stars as X-ray sources. FULL TEXT IN SPANISH

Nuñnez, N. E.; Luna, G. J. M.


Actividad estelar en estrellas con planetas a partir de espectros de CASLEO  

NASA Astrophysics Data System (ADS)

We analyze the long-term activity of seven stars which host near Jupiter-like planets (0.40M_J

Flores, M.; Buccino, A.; Saffe, C.; González, F.; Mauas, P.


Coeficientes de extinción del CASLEO y características del CCD directo con el telescopio JS  

NASA Astrophysics Data System (ADS)

We computed atmospheric extinction coefficients at the Complejo Astronómico El Leoncito (CASLEO) in UBVRI bands. They were obtained from photometric observations carried out in December 2011 using the 2.15-m ``Jorge Sahade'' Telescope (JS) and we compared then with previous published values. We also computed several instrumental parameters of the ROPER CCD 1300B camera working in direct mode and we presented results of a linearity test. FULL TEXT IN SPANISH

Baume, G. L.; Campuzano-Castro, F.; Fernández-Lajús, E.; Gamen, R.; Haucke, M.; Marchesini, E. J.; Molina-Lera, J. A.; Rossignoli, N. L.; San Sebastián, I. L.; Tello Huanca, E. L.; Zanardi, M.


Modelos autoconsistentes de sistemas estelares cuspidales y triaxiales con distribución de velocidades casi isotrópica  

NASA Astrophysics Data System (ADS)

It has been shown in many works that it is possible to build stable, self-consistent models of triaxial stellar systems, even with cusps, and containing high percentages of chaotic orbits. Since all these models have been obtained from cold collapses, their velocity distributions are strongly radial. Also, chaos was computed using either Lyapunov exponents or SALI. However, models obtained by adiabatic deformation of spherical systems, in which the velocity distribution is more isotropic, showed a very low level of chaos, though it must be noted that the method of detecting chaos used in this case, namely the variation of orbital frequencies, is less sensitive than the abovementioned methods. In this work, we present models obtained by adiabatic deformation, in which we compute the fraction of chaotic orbits using both Lyapunov exponents and variation of orbital frequencies. Our results show that the percentages of chaotic orbits is significant, though they are smaller than those obtained in models with strong radial velocity components. FULL TEXT IN SPANISH

Carpintero, D. D.; Muzzio, J. C.; Navone, H. D.; Zorzi, A. F.


Pros and cons of a group webpage design project in a freshman anatomy and physiology course.  


To generate motivation and promote the development of written communication skills, students in a freshman-level anatomy and physiology course for nonmajors created group webpages describing historically important diseases. After the groups had been formed, each individual was assigned specific components of the disease (e.g., causes or treatments), which were subsequently combined into a final product. Interviews and questionnaires were used to document students' previous educational experiences regarding, and attitudes toward, the project. Students learned more about website design than about anatomy and physiology, but students preferred the assignment over traditional term papers. Although most students could find relevant information for this project on the internet, they were uncritical in judging the accuracy of the information they found. PMID:18057407

Crisp, Kevin M; Jensen, Murray; Moore, Randy



Características clínicas de los pacientes tratados con implante percutáneo de la prótesis aórtica Corevalve  

Microsoft Academic Search

Introduction and ObjectivesPercutaneous implantation of an aortic valve prosthesis has emerged as a therapeutic option for patients with severe symptomatic aortic stenosis for whom surgical valve replacement is not suitable. We describe the clinical characteristics of patients treated with percutaneous Corevalve aortic prosthesis.

Ana Flores-Marín; Antonio Muñoz-García; Juan H. Alonso-Briales; Manuel Jiménez-Navarro; Antonio Domínguez-Franco; Juan Caballero-Borrego; José M. Hernández-García; Eduardo de Teresa-Galván



Tratamiento percutáneo de las bioprótesis aórticas disfuncionantes con la prótesis CoreValve ®  

Microsoft Academic Search

Recently, percutaneous aortic valve replacement has emerged as a therapeutic option for patients with severe symptomatic aortic stenosis and a high surgical risk. We report our initial experience in four patients with percutaneous implantation of a CoreValve aortic prosthesis to treat aortic bioprosthesis dysfunction involving aortic stenosis or regurgitation. In-hospital and medium-term outcomes were analyzed. The procedure was performed under

José M. Hernández-García; Antonio J. Muñoz-García; Juan H. Alonso-Briales; Manuel F. Jiménez-Navarro; Antonio J. Domínguez-Franco; Isabel Rodríguez-Bailón; Eduardo Olalla-Mercadé; Eduardo de Teresa-Galván



Linfoma cutáneo de células B de la zona marginal tratado con rituximab  

Microsoft Academic Search

Marginal zone B-cell lymphoma (MZL) is probably the most frequent of the primary cutaneous B-cell lymphomas, which are entities with indolent behavior. Clinically, it appears in middle-aged patients as papules, nodules or erythematous plaques, solitary or multiple, on the trunk and proximal part of the limbs. The prognosis is excellent despite frequent cutaneous recurrences.We present the case of a 40-year-old

Javier Pedraz; Yolanda Delgado; Maximiliano Aragüés; Javier Fraga; Amaro García-Díez; Jesús Fernández-Herrera



La frecuencia cardiaca fetal en pacientes con diagnóstico de embarazo prolongado  

Microsoft Academic Search

Basal values of fetal heart rate (FHR) and amplitude of the accelerations were determined in patients with prolonged pregnancy and were compared with those in a control group. The study design was open, prospective, comparative and exploratory.The sample consisted of 40 patients divided into two groups. Group 1 (problem group) was composed of 20 patients with prolonged pregnancies. Group 2

G. Romero-Salinas; V. H. Pulido; M. E. Gutiérrez Cárdenas; R. García Cavazos; M. Torres Cosme; G. Lizaola Díaz; M. Shea; L. García López



The value of echocardiographic diagnosis and pros and cons of steroids treatment in Kawasaki disease  

Microsoft Academic Search

Echocardiography and coronary angiography is mainly used for the diagnosis of cardiovascular disease, we mainly evaluate the value of two-dimensional echocardiography (2D echo) in Kawasaki disease (KD). Steroids role in the primary treatment of KD is controversial. Our aim is to conduct a study to ascertain whether the addition of steroids to intravenous immunoglobulin (IVIG) for the treatment of KD

Xiaomei Zhang; Jinghui Sun



I-I-Con: A visual communications paradigm to integrate industrial control system engineering  

Microsoft Academic Search

The process control industries have seen a great explosion in different function block programming languages over the last five years. Each of these languages is proprietary meaning that there is no ability to port one function block program to another platform. Some standards for process control symbology have been developed, but they lack the richness of graphic expression often contained

Debbie K. Carter; Albert D. Baker; W. Perry Alexander



Revision of late periprosthetic infections of total hip endoprostheses: pros and cons of different concepts  

Microsoft Academic Search

Many concepts have been devised for the treatment of late periprosthetic infections of total hip prostheses. A two-stage revision with a temporary antibiotic-impregnated cement spacer and a cemented prosthesis appears to be the most preferred procedure although, in recent times, there seems to be a trend towards cementless implants and a shorter period of anti- biotic treatment. Because of the

Bernd Fink


Outcome valutativo in pazienti sottoposte a terapia con Ranelato di Stronzio: MOC QUS  

Microsoft Academic Search

Introduzione L'osteoporosi è una patologia a carico del sistema scheletrico che si caratterizza sia per una riduzione della massa ossea che per un deteriorarsi della microarchitettura trabecolare, responsabili dell'au- mento della fragilità ossea e quindi della maggiore predisposizione all'insorgenza di fratture. In Medicina Riabilitativa la possibilità di monitorare e gestire direttamente il trattamento per la cura dell'o- steoporosi rappresenta un



Observaciones de la corona solar interior con un coronógrafo de espejo  

NASA Astrophysics Data System (ADS)

El plasma de la corona solar es un buen indicador de las líneas de fuerza del campo magnético. Por lo tanto, el análisis de estructuras coronales cuasiestacionarias en la corona da importante información sobre el campo magnético y la actividad asociada. Se trata de poner límites a los modelos teóricos existentes mediante el estudio de distintas estructuras en la corona interior. En agosto de 1997 comenzó a operar el coronógrafo solar (MICA) en El Leoncito como parte del Observatorio Solar Alemán-Argentino. Desde su instalación obtiene imágenes de la corona solar (1.05 a 2.0 radios solares) en 2 líneas espectrales correspondientes a la emisión de Fe XIV y Fe X. El instrumento puede obtener imágenes cada minuto por lo que es ideal para estudiar procesos rápidos. Presentamos observaciones recientes que muestran la capacidad del coronógrafo así como la evolución de algunos eventos dinámicos observados por MICA.

Stenborg, G.; Schwenn, R.; Francile, C.; Rovira, M.


La Interacción de la Luz con las Biomoléculas  

NSDL National Science Digital Library

En esta lección se describe la naturaleza de la luz, la energía de los fotones y como dicha energía puede ser transferida a las biomoléculas. Se describen también tanto los procesos benéficos como los procesos dañinos por medio de los cuales las biomoléculas disipan la energía recibida.


Clinical use of amino acids as dietary supplement: pros and cons  

Microsoft Academic Search

Nitrogen supply is pivotal for the maintenance of life. Amino acids can be utilized to synthesize both glucose and lipids.\\u000a The opposite, i.e., production of amino acids from either one of them, is not possible in the absence of other amino acids\\u000a as donors of nitrogen. The quality of amino acid content in protein has been re-evaluated recently, and the

Francesco S. Dioguardi



La vigilancia del embarazo en gestantes con Hepatitis B y C  

Microsoft Academic Search

SUMMARY The vertical transmission of hepatitis B virus of mothers to infants can be made because the mother suffers the disease during the gestation or because she is chronics hepatitis B carrier. The first antigen that is detec- ted in the serum after the infections is the HbsAG. The prenatal determination of HbsAG must carry out all pregnant women. Recombinant

M. V. Albi; I. Pereira; M. T. Merino; F. López; A. González-Spínola; B. Adiego; A. Palacín; A. López Salvá


El género Brucella y su interacción con el sistema mononuclear fagocítico  

Microsoft Academic Search

Non-specific resistance is a fundamental component of the host immune response. The mononuclear phagocytic system (MPS) is part of innate resistance effector mechanisms, and is involved in several homeostatic, inflammatory and immunologic events. Mononuclear phagocytes (MNP), which are cells belonging to the MPS, play a central role in the main functions of multicellular organisms. Its early interaction with pathogens determines

Mirta B. Aréstegui; Javier Domínguez



Sueño y Sistema Inmune: Diferencias en Variables Inmunológicas en Sujetos con Apnea y Controles  

Microsoft Academic Search

Recently, interest for studying the relationship between sleep and immunological system has increased. The Obstructive Sleep Apnea Syndrome (OSAS) is a disorder characterized by repetitive episodes of respiratory cessation that occur during sleep. Recent studies have suggested the need to study the relation between OSAS and immune system. The objective of this study was to analyze the differences between subjects

Pablo Vera-Villarroel; Ana I. Sánchez; Gualberto Buela-Casal




Microsoft Academic Search

With the objective to describe the extent of treatment adherence and identify factors that impact antiretroviral treatment among individuals participating in the HIV treatment program of the Ministry of Health in Tamaulipas, Mexico between June 2008 and October 2008. A cross-sectional study including all individuals in the treatment program (117) was carried. To identify non-adherence in the last four days

Maria Isabel Peñarrieta; Tamil Kendall; Norma Martinez; Ana María Rivera; Nora Gonzales; Elva del Angel



Diseño de una vía clínica para la atención a los pacientes con esclerosis múltiple  

Microsoft Academic Search

IntroductionClinical pathways are standard health care methods to coordinate clinical work, reduce inter-clinician variability, improve patient care and increase staff and patient satisfaction. The aim of this study is to develop a clinical pathway capable of organising and developing standard procedures for diagnosis, treatment and care in patients with multiple sclerosis and to coordinate all medical specialists involved in this

C. Oreja-Guevara; A. Miralles; J. García-Caballero; S. Noval; L. Gabaldón; M. D. Esteban-Vasallo; M. J. García-Matres; C. Bayón-Pérez; A. Royo; A. González; A. Hernanz; M. R. López-Pajares; J. L. Morante; E. Díez-Tejedor



Cómo enseñar a los padres a hablar con sus hijos acerca de ...  

Center for Food Safety and Applied Nutrition (CFSAN)

Text Version... aprendieron cuántas calorías comían; aprendieron que su bolsa de papas favoritas tiene en realidad tres porciones y media; aprendieron que los ... More results from



Microsoft Academic Search

bjectives: To assess quality of life in patients diagnosed with epidermoid carcinoma of the larynx, after supracricoid partial laryngectomy (SCPL) with cricohyoidoepiglottopexy (CHEP). To examine how quality-of-life may be associated to the treatment received: neck dissection, decannulation and radiotherapy. Patients and method: A descriptive, observational, cross-sectional study was conducted involving 26 patients out of a group of 51. They were



Assessment of medical knowledge: the pros and cons of using true/false multiple choice questions.  


True/false multiple choice items, commonly referred to as true/ false multiple choice questions (MCQs), were previously a widely used selected response examination format. They can be written relatively easily and cover a wide range of content. Educational researchers have however highlighted several adverse features of this format that make it inappropriate for many assessment settings. These include: (i) there is a high chance of guessing the correct answer; (ii) some marks are not awarded for knowing the correct answer, but for knowing that an answer is incorrect; (iii) they are weak in discriminating between high and low performers; (iv) identifying items which are absolutely true or false may lead to assessment of trivial knowledge; (v) there are difficulties with constructing flawless items; (vi) they may not encourage learning around the items; and (vii) they may not assess what they purport to assess. Many assessment agencies abandoned the use of this format decades ago due to these shortcomings. The use of single best answer (SBA) and extended matching item (EMI) formats helps overcome or minimize the above weaknesses. Assessors who plan to change to SBA or EMI formats from true/false MCQs may, however, need to increase the number of questions to include a representative sample of the curriculum (lengthening the question paper). However, they may not need to increase the examination time, as in general students can answer more SBAs or EMIs than true/false MCQs per unit time. It is time that we reflect upon the disadvantages of true/false MCQs and review their place in our assessment toolkit, as their use in summative examinations may not be fair to students, especially 'good' students. PMID:22208143

Chandratilake, Madawa; Davis, Margery; Ponnamperuma, Gominda


(Con)Texts for Cultural and Linguistic Hybridity among Somali Diaspora Youth  

Microsoft Academic Search

The perspectives of immigrant youth are important to be aware of because they can reveal the powerful role society has in framing and forming the range of possibilities available to them. Culturally speaking, immigrant youth often face mismatches between home and school values, but they sometimes encounter intracultural struggles as well. This article reviews literature about immigrant cultural adaptation and

Martha Bigelow



How patients stress, con, and intimidate physicians to file dubious disability reports.  

PubMed Central

This study was undertaken to determine the association between health providers' stress and performances, and patients who presented with disability forms that the providers did not feel were justified. Two questionnaires were given to health-care providers at the Family Practice Clinic, Martin Luther King/Drew Medical Center, Los Angeles, California. One questionnaire assessed the level of stress they suffered from, and a second questionnaire assessed how these types of patients may affect their general performance. The data suggested that the performance of providers was definitely affected by hostile, demanding, threatening, and malingering patients. The students, residents, nurses, and clinic administrative staff were all affected. Third-year medical students and foreign-trained doctors appeared not to be affected as much, probably because of a lack of knowledge about the "system" or because they preferred not to "rock the boat".

Brooks, T. R.



Developmental trauma disorder: pros and cons of including formal criteria in the psychiatric diagnostic systems  

PubMed Central

Background This article reviews the current debate on developmental trauma disorder (DTD) with respect to formalizing its diagnostic criteria. Victims of abuse, neglect, and maltreatment in childhood often develop a wide range of age-dependent psychopathologies with various mental comorbidities. The supporters of a formal DTD diagnosis argue that post-traumatic stress disorder (PTSD) does not cover all consequences of severe and complex traumatization in childhood. Discussion Traumatized individuals are difficult to treat, but clinical experience has shown that they tend to benefit from specific trauma therapy. A main argument against inclusion of formal DTD criteria into existing diagnostic systems is that emphasis on the etiology of the disorder might force current diagnostic systems to deviate from their purely descriptive nature. Furthermore, comorbidities and biological aspects of the disorder may be underdiagnosed using the DTD criteria. Summary Here, we discuss arguments for and against the proposal of DTD criteria and address implications and consequences for the clinical practice.



The pros and cons of trading water: A case study in Australia  

NASA Astrophysics Data System (ADS)

Water is a commodity, and water rights can be freely traded in an open market. Proponents of the free market approach argue that it leads to the most efficient allocation of water resources, as it would for any other commodity. However, unlike some commodities, water is critical for human life, for many human activities, and as an environmental resource. When such an essential commodity becomes scarce, as frequently happens in Australia, which is prone to sudden and dramatic droughts, severe problems can occur quickly. In Australia's Murray Darling Basin, the country's largest agricultural region, the government had historically controlled the distribution of water rights. However, under these controls, a selected few controlled a large share of the water. To resolve this problem of overallocation, a free market approach was put in place in the early 1990s.

Bhattacharya, Atreyee



Nuclear Power: Pros and Cons. What We Make. Science and Technology Education in Philippine Society.  

ERIC Educational Resources Information Center

|This module brings together in a panel discussion opposing views and supporting data on the first Philippine nuclear power plant in Morong, Bataan. It extends the discussion of issues and ideas about nuclear power in the dialogue "Go Nuclear" (which should be read before starting this panel discussion). The module deals with the environmental,…

Philippines Univ., Quezon City. Inst. for Science and Mathematics Education Development.


Con la Ayuda de Dios, los Latinos Participan: Religiosity and Civic Engagement in Latino Populations  

Microsoft Academic Search

Literature has shown that religiosity positively correlates to increased levels of civic engagement, including political participation. It also shows that religiosity is one of the greatest predictors of position on key political issues, including though not limited to family values issues such as abortion and gay marriage. In another vein, studies such as those done by Verba, Scholozman and Brady

Kiku Huckle; Sergio Garcia-Rios


Pros and cons of post-mortem CT imaging on aspiration diagnosis.  


Recently, the field of forensics has experienced a rapid increase in the use of modern cross-sectional imaging in forensic investigations. We examined the value of post-mortem computed tomography (CT) imaging relative to autopsy for distinguishing aspiration into the lungs from airways, from lung alterations due to other causes, and for identifying the aspirated material. We selected 54 bodies submitted to whole-body CT scanning prior to autopsy. All cases had autopsy findings of blood (31 cases), fresh water (12 cases), or gastric content (11 cases) aspiration. The radiological images were retrospectively analyzed for airway and lung aspiration. In all cases, CT imaging detected pulmonary abnormalities suggestive of aspiration. Nevertheless, analysis of the CT images alone was not able to identify the aspirated material or to distinguish pulmonary findings of aspiration from lung changes due to other causes, except for a few cases of hemo-aspiration. However, due to its ability to visualize the entire parenchyma, CT imaging was superior to autopsy in providing additional data about the distribution and severity of the aspiration as well as in detecting small abnormalities. Post-mortem CT imaging should be considered as a superior tool for forensic investigations of aspiration due to its ability to document diagnostic conclusions and to guide the forensic pathologist during lung tissue examination. PMID:21030285

Filograna, Laura; Bolliger, Stephan A; Ross, Steffen G; Ruder, Thomas; Thali, Michael J




Microsoft Academic Search

The inspiratory muscular fatigue produces a shortfast respiratory pattern. When the inspiratory muscular fatigue is due to a maximum exercise, this pattern must rind in the last phase of excercise and during the recuperation period. The objetive of this study was to prove the respiratory pattern diferences, if any, throughout the effort and recuperation periods, as well as to analize

Ortega Ruiz; Fernández Guerra J; Valenzuela Mateos


Enron. Con: “He that filches from me my good name … makes me poor indeed”  

Microsoft Academic Search

This critique functions as an introduction to this special issue of Critical Perspectives on Accounting; an edition that embraces themes pertaining to the catastrophic collapse of Enron. In an effort to place the research published in this edition in context, I provide a critical analysis of the accounting and corporate governance implications of the demise of Enron, the subsequent public

Brendan T O’Connell



Chicanery in the corporate culture: WorldCom or world con?  

Microsoft Academic Search

Repercussions from the failure of WorldCom have profoundly affected all the company’s stakeholders. As evidence of malfeasance escalates, the company may prove to have been a mere mirage without substance or soul. This paper addresses one particular facet of the company’s dramatic and devastating demise. By authorizing personal loans to Bernie Ebbers, the board ultimately compromised the effectiveness and credibility

David P. Boyd



Adeno-associated virus vectors for gene therapy: more pros than cons?  

Microsoft Academic Search

Gene therapy vectors based on the adeno-associated virus (AAV) are being developed for a widening variety of therapeutic applications. Enthusiasm for AAV is due, not only to the relative safety of these vectors, but also to advances in understanding of the unique biology of this virus. This review examines a number of long-standing concerns regarding the utility of AAV for

Paul E. Monahan; R. Jude Samulski




Microsoft Academic Search

Summary Due to the increased more and more high in VIH seroconversion rate and AIDS's development, which produce an fatal evolution of affected persons, a bad quality of life and underprivileges in order to social aspects, was realized multiples efforts in concerned to illness control. Up to now, the preven- tive and therapeutic methods reached indisputable benefits on affected persons

Christian S. Globaz; Diego A. Fraga Betancur; Julio C. Baez; Fernando J. Gómez Rinesi


Military, masculinity and mediated representations: (con)fusing the real and the reel  

Microsoft Academic Search

In this paper I argue that it is time to rethink the military within Management and Organization Theory. The starting point for this discussion is a juxtaposition of the (lack of) study of the military within Management and Organization Theory compared with the recent (and sustained) interest in depicting war, the military and the military subject within popular culture. I

Richard Godfrey



40 CFR 227.27 - Limiting permissible con-cen-tra-tion (LPC).  

Code of Federal Regulations, 2013 CFR

...disposal site. Bioassays, except on phytoplankton or zooplankton, shall be run for a minimum of 96 hours under temperature, salinity, and dissolved oxygen conditions representing the extremes of environmental stress at the disposal site. Bioassays on...



Pruebas de alergia y características clínicas en lactantes y preescolares con dermatitis atópica  

Microsoft Academic Search

Introduction. Patients with atopic dermatitis (AD) showed an elevated frequency of sensitization for different allergens by means of allergy testing (AT). Possible clinical differences between such patients with AD and positive AT have not been previously studied in our region. The aim of the study was to determine the frequency of allergic sensitization in a group of children with AD



Gestire il cliente con il CRM e la Business Intelligence: tra storia e dati  

Microsoft Academic Search

MANAGING CUSTOMER BEHAVIOUR BY CRM AND BUSINESS INTELLIGENCE: BETWEEN HISTORY AND DATA. In this paper we introduce some definitions concerning Customer Relationship Management and Business Intelligence and we emphasize how they can improve business strategies and performances. We show how Data Mining techniques can be used for CRM analysis, understanding customer behaviour in order to forecast future actions, improving decisions




Applications of Contingency Management Principles to the College Classroom: The Con Game Project.  

ERIC Educational Resources Information Center

|A system of teaching based on the principles of the Token economy was developed. This system allowed students to choose not only the pace at which they would advance through a curriculae but also allowed them the choice of output mode (paper versus tests) and areas of concentration. By rewarding student participation in helping to find…

Swenson, Leland C.


Thermal remote sensing of crop water status: pros and cons of two different approaches  

Technology Transfer Automated Retrieval System (TEKTRAN)

Recent climate change has lead, in many places around the world, to a decrease in the availability of water resources. This limited water availability is decreasing the cost-effectiveness of irrigated agricultural crops, and practices reducing the required amount of water without decreasing the qua...


Pros and cons of a pushover analysis of seismic performance evaluation  

Microsoft Academic Search

The static pushover analysis is becoming a popular tool for seismic performance evaluation of existing and new structures. The expectation is that the pushover analysis will provide adequate information on seismic demands imposed by the design ground motion on the structural system and its components. The purpose of the paper is to summarize basic concepts on which the pushover analysis

G. D. P. K. Seneviratna



Pros and cons of radical cystectomy in the treatment of T1G3 bladder cancer  

PubMed Central

The management of T1G3 (or high-grade T1) bladder cancer poses a challenging clinical dilemma to the urologist. There are good data supporting bladder conservative therapy with repeat transurethral resection and administration of Bacille Calmette-Guérin (BCG) intravesical therapy but this must include maintenance regimens since only maintenance BCG has been shown to decrease tumor recurrence and progression. Concern over worse survival with a delay in definitive therapy has prompted many to recommend immediate cystectomy for T1G3 disease. Ultimately, the decision needs to be individualized and although certain pathologic factors (T1b disease, early recurrence or progression within three months of BCG therapy, lymphovascular invasion and variant histology) are prognostic of progressive disease, no definitive risk factors for tumor progression have been identified.

Agarwal, Piyus K.; Kamat, Ashish M.



Organic Farming: Pros and Cons for Soil Health and Climate Change  

Microsoft Academic Search

\\u000a The rapid expansion of organic farming systems means that it is timely to consider their responses to climate change. The\\u000a overall value of ecosystem services delivered is higher and the energy use of organic farms is lower than conventional comparators,\\u000a whether assessed per unit area or per tonne of product. Increases in the amount of carbon stored under organic management

Elizabeth Stockdale


Riesgo cardiovascular en pacientes diabéticos tipo 2 con o sin síndrome metabólico asociado  

Microsoft Academic Search

IntroductionCardiovascular diseases are the leading cause of morbidity and mortality in people with type 2 diabetes (DM2). Insulin resistance has been proposed as a link among the various risk factors. The aim of this study was to assess the estimated risk of metabolic syndrome (MS) in patients with DM2 and to evaluate the impact of MS on cardiovascular risk in

Inmaculada Muñoz Roldán; María Belén Martín Puig; María Teresa Agudo Villa; Carlos Recarte García Andrade; Jesús Millán Núñez-Cortés



The Mantle Plume Hypothesis Pro and Con: Evidence from Earth's Most Voluminous Large Igneous Provinces  

NASA Astrophysics Data System (ADS)

Mantle plumes are upwellings of large volumes of mantle material in focused conduits, the leading ends of which are referred to as plume heads. Large igneous provinces (LIPs) are suspected to form from magmatism resulting from plume head decompression melting, but, evidence for this theory for the origins of LIPs is mixed. We have now reached the point of having either to modify the theory to fit characteristics of individual LIPs or to abandon the theory and search for a more unifying explanation. A case study of the two biggest LIPs on Earth - the Ontong Java Plateau (OJP) in the western equatorial Pacific Ocean, and the Kerguelen Plateau / Broken Ridge (KPBR) in the southern Indian Ocean - allows us to examine key predictions of mantle plume theory, including: (1) subaerial eruption of large portions of oceanic LIPs (2) large extents of partial melting in the plume head, resulting in tholeiitic basalt-type magmas, coupled with (3) rapid formation of the LIP, (4) post-formation subsidence comparable to normal oceanic lithosphere, and (5) the presence of a hotspot track and/or an active hotspot. The KPBR formed largely above sea level over a protracted time period ( ˜120 Ma - present) in the growing Indian Ocean basin. Early Cretaceous melts were derived from a heterogeneous source, complicated by subsequent local assimilation of continental crust. Most lavas recovered from the plateau are tholeiitic, but alkalic and evolved volcanics occur in several, widespread locations. Subsidence of the plateau has followed predictions for normal oceanic lithosphere. A prominent hotspot track, the Ninetyeast Ridge, connects Broken Ridge with Early Cretaceous continental basalts on the eastern margin of India. The Kerguelen hotspot is still active today, creating Heard and MacDonald Islands on the central plateau. The OJP was constructed well below sea level on existing Pacific lithosphere. Nearly the entire volume of magma is believed to have been created instantaneously, at ˜120 Ma, from large degrees of partial melting ( ˜30%) of a homogeneous source. Melting extents were high, so either a large temperature anomaly, or a major decompression event is required because volatile contents were low. It has subsided relatively little, or erratically, since its formation. No known hotspot track is associated with the OJP, nor is any active hotspot. Some of these observations agree with expectations of a mantle plume head origin, but several are contrary to predictions. Alternative mechanisms for the formation of LIPs, including extraterrestrial (i.e. bolide impact) or tectonic causes, are also problematic. A few of the obvious concerns are (1) large bolide impact events might not occur often enough to account for the number of known LIPs, (2) tectonic origins for LIPs ignore the presence of LIPs on planetary bodies where evidence for plate tectonics is nil or scant. A common mechanism for the formation of LIPs is highly desirable, yet, at present, all existing hypotheses appear in some way deficient.

Ingle, S.; Coffin, M. F.



40 CFR 227.27 - Limiting permissible con-cen-tra-tion (LPC).  

Code of Federal Regulations, 2010 CFR

...each representative of phytoplankton or zooplankton, crustacean or mollusk, and fish...Bioassays, except on phytoplankton or zooplankton, shall be run for a minimum of Bioassays on phytoplankton or zooplankton may be run for shorter periods of...



40 CFR 227.27 - Limiting permissible con-cen-tra-tion (LPC).  

Code of Federal Regulations, 2010 CFR

...each representative of phytoplankton or zooplankton, crustacean or mollusk, and fish...Bioassays, except on phytoplankton or zooplankton, shall be run for a minimum of Bioassays on phytoplankton or zooplankton may be run for shorter periods of...




Microsoft Academic Search

SUMMARY We have carried out this research because accidents are a serious public health problem in Mexico. They are the third overall mortality cause and the first among young adults. In addition, in our country, the study of posttraumatic stress disorder (PTSD) has not been focused sufficiently on accidents, not to speak of motor vehicles accidents. Among the different types

Ernesto Pérez-Rincón Merlín; Catalina González-Forteza; Luciana Ramos Lira; José Alberto Jiménez Tapia




Microsoft Academic Search

This article presents some psychosocial and juridical aspects of voluntary manslaughters that occurred in Costa Rica during the 1998-1999 period. The study is based on guilty verdicts given by the justice courts. The outcomes indicate that there are no significant differences between manslaughter and murder; fire weapons were the main way for committing murder; nearly one in four offenders had

Mario Alberto sáenz Rojas



La ganadería extensiva, ¿es compatible con la conservación de la biodiversidad y de los suelos?  

Microsoft Academic Search

Is extensive livestock production compatible with biodiversity and soil conservation?: The effect of commercial livestock production on biodiversity and soil conservation is difficult to evaluate due to the lack of relicts without livestock, landscape heterogeneity and the complexity of responses. We analyzed the available information and models, integrating different scales, to describe in what conditions commercial livestock production results compatible



Islamophobia\\/Hispanophobia: The (Re) Con?guration of the Racial Imperial\\/Colonial Matrix  

Microsoft Academic Search

There are enormous historical and social differences in the imperial making of Islamophobia--the fear and the hatred toward a powerful and widespread religion--and Hispanophobia--the fear and hatred toward secular subaltern forces with mixed religious beliefs that emerged in the seventies in the U.S. without the extended political connections or support from \\

Walter D. Mignolo



Diferencias en la percepción del dolor relacionadas con las variables sexo y edad  

Microsoft Academic Search

The results show that women have higher average score s than men in the three domains, as well as in the global score . F u r t h e rm o re, differences according to age are only found in the affective and sensorial domains. Older patients (more than 65 years) obtained significantly greater average score s in the

C. Ramíre; R. Esteve; A. E. López-Martínez


Internet y riesgo sexual en hombres que tienen sexo con hombres  

Microsoft Academic Search

Objective1) To compare sociodemographic characteristics, Internet use to seek sexual partners, and sexual behavior in two samples of men who have sex with men: one sample that was surveyed on-line and another that was interviewed in gay venues. 2) To determine the variables associated with unprotected anal intercourse with sexual partners met on-line.

Percy Fernández-Dávila; Kati Zaragoza Lorca



Auto-concepto y desempeño académico en adolescentes. Relaciones con sexo, edad e institución  

Microsoft Academic Search

The aim of this work was to study self-concept (academic, social, emotional and familiar) and academic achievement in language and math exploring sex, grade, and institutional type relations. 850 public and private basic general education students (7th and 9th grades) from Mar del Plata (Argentine) were assessed with the Cuestionario de Autoconcepto Forma A (AFA) and tested in language and

Sebastián Urquijo



Ethical considerations in health care reform: pros and cons of the Affordable Care Act.  


The sweeping changes to be implemented over the next few years by the Affordable Care Act (ACA) will have a profound effect on how health care is delivered and will subject society, providers, and patients to many new and different ethical dilemmas, challenges, relationships, and unintended consequences. This contribution discusses the ethical considerations of the ACA from 3 perspectives: society, health care providers in general, and dermatologists specifically. PMID:22330657

Pariser, David M


Pro & con. State lawsuits won't succeed in overturning the individual mandate.  


The Patient Protection and Affordable Care Act of 2010 looks to the states to implement its insurance regulatory reforms and exchanges, retaining for the national government what could be construed as merely a backup role. The law offers federal support to the states, along with opportunities to act creatively to meet residents' needs. It thus is unfortunate that a number of states have responded by challenging the law, both legislatively and judicially, rather than getting on with implementation. These challenges have no legal merit and are a serious distraction from the real work that lies before the states. PMID:20530360

Jost, Timothy S



Did early Renaissance painters trace optical projections? Evidence pro and con  

NASA Astrophysics Data System (ADS)

Recently it has been theorized that some European painters as early as 1420 used concave mirrors (and, later, converging lenses) to project real inverted images onto their supports which they then traced and painted over. We review the image analytic, historical and art historical evidence and counter-evidence for this bold claim, focusing on key paintings in the debate. While some of the evidence is consistent with the use of optical projections in the 15th century, all such evidence is also consistent with other explanations as well. More importantly, for those paintings highlighted as supporting the projection theory, there is much evidence that is inconsistent with the use of optics or extremely difficult to explain as arising from the use of optics. Further, there is no historical documentary evidence from the 15th century suggesting anyone had even seen an image of an illuminated object projected onto a screen -- the first step in the proposed projection method. The projection method would have been the most sophisticated optical procedure of its day, which theory proponents speculate was discovered by artists, not the scientists who were actively exploring optical systems. Because the burden of proof lies foursquare upon the theory"s proponents -- the revisionists -- in the absence of compelling reasons to reject "traditional" (non-optical) explanations we must reject the projection theory. We conclude by rejecting the claims that the optical projection theory has been "proven."

Stork, David G.



Interactions between nested sunspots II. A conned X1 flare in a delta-type sunspot  

Microsoft Academic Search

We study the flaring activity in a nest of sunspots in which two bipolar regions emerge inside a third one. These bipolar regions belong to a large complex of activity (McMath 15314) formed by ve bipoles on its May 1978 rotation. The usual spreading action during the growth of the bipoles leads to the formation of a -conguration: the preceding

V. Gaizauskas; C. H. Mandrini; P. Demoulin; M. L. Luoni; M. G. Rovira


Proceso de cuidados en un paciente con espina bífida. Caso clínico  

Microsoft Academic Search

Spina bifida is a congenital malformation of the lumbar spine. We developed a nursing care plan in a 12-year-old girl with this malformation who attended a special education school. Using Gordon's health patterns, we assessed the patient and identified the following nursing diagnoses: imbalanced nutrition: more than body requirements, urinary incontinence, impaired transfer ability, risk for infection, risk of impaired

Jacob González Gancedo; Daniel Fernández García



The Ponzi Scheme Puzzle: A History and Analysis of Con Artists and Victims  

Microsoft Academic Search

In a Ponzi scheme, new investments are used to pay existing investors, to cover the cost of salespersons, and to finance the Ponzi schemer's satisfying lifestyle. Although Charles Ponzi recruited investors in Boston in 1919 and died in 1949, his design and mode of operation are alive and well today. Indeed, losses from Ponzi schemes in the United States are

Tamar Frankel


Degradación de colorantes industriales con hongos ligninolíticos Degradation of industrial dyes with white rot fungi  

Microsoft Academic Search

White rot fungi have shown a great potential for degrading recalcitrant chemicals compounds as PAHs, explosives, pesticides, dyes, etc. This capacity is due mainly to an extracellular enzymatic complex that they use naturally

Mariana Cardona; Juliana Osorio; Juan Quintero


ConXict between egg recognition and egg rejection decisions in common cuckoo (Cuculus canorus) hosts  

Microsoft Academic Search

Common cuckoos (Cuculus canorus) are obligate brood parasites, laying eggs into nests of small songbirds. The cuckoo hatchling evicts all eggs and young from a nest, eliminating hosts' breeding success. Despite the consistently high costs of parasitism by common cuckoos, great reed warbler (Acrocephalus arundinaceus) hosts sometime accept and other times reject parasitic eggs. To explore the cognitive basis of

Csaba Moskát; Márk E. Hauber



Outsourcing Human Security: The Pros and Cons of Private Security Companies in Peacekeeping.  

National Technical Information Service (NTIS)

The United Nations (UN) is an international organization that acts in world affairs with the proclaimed aim of ending the 'scourge of war' and promoting world peace. The UN often uses peacekeeping to further this goal. This dissertation considers the pote...

D. G. Straub




Microsoft Academic Search

SUMMARY Objective: To assess the effects of Hyaloglyde® gel (or auto-cross-linked polysaccharide (ACP) gel; Fidia Advanced Biopolymers, Abano Terme, Italy), a hyaluronan-derivative polymer, on flexor tendon repair in zone II. Methods: Fifteen patients (10 males, 5 females), aged between 17 and 47 years old, all with Zone II flexor tendon injuries, were divided in two groups (A and B). The



Tableros de Virutas Aglomeradas con Cemento Portland (Wood - Portland Cement Particle Boards).  

National Technical Information Service (NTIS)

Research was done to establish the physical and mechanical properties for wood-cement particle boards. Two species of wood were tested: Guarea sp. and Cupressus lusitanica. The furnish was produced by regular palners, and machine saws available in any fur...

J. B. Tuk




Microsoft Academic Search

Infants exposed to certain drugs in utero can become physically dependant on them and after birth they suffer the withdrawal symptoms, this is phenomenon is called neonatal abstinence syndrome (NAS). Infants with NAS have multi-system dysfunction involving the central nervous, gastrointestinal and respiratory systems. The present review analyses the literature related to opiates consumption by pregnant women and NAS.

José Henry Osorio



Cough hypersensitivity syndrome is an important clinical concept: a pro/con debate.  


The major etiologies of chronic cough are generally accepted to consist of upper airway cough syndrome (formerly postnasal drip syndrome), eosinophilic airway inflammation (asthma, nonasthmatic eosinophilic bronchitis), and gastroesophageal reflux disease (GERD). However, only a small percentage of patients with these very common conditions suffers from chronic cough. Furthermore, acute cough due to viral upper respiratory tract infection (URI) is almost always a transient, self-limited condition, yet in a small subgroup of patients, URI heralds the onset of chronic, refractory cough. The cough hypersensitivity syndrome has been proposed to explain the occurrence of chronic cough in a subgroup of patients exposed to the same putative triggers as the vast majority of the population in whom chronic cough does not result. Although conceptually the cough hypersensitivity syndrome may be intellectually satisfying, differences of opinion remain as to whether this newly recognized entity is of clinical significance, i.e., useful for the treatment of patients suffering from chronic cough. The Third American Cough Conference, held in New York in June 2011, provided an ideal forum for the debate of this issue between two internationally recognized authorities in the field of cough. PMID:22186805

Morice, Alyn H; McGarvey, Lorcan P A; Dicpinigaitis, Peter V




Microsoft Academic Search

The recovery of plastic wastes could be of industrial interest, because it represents a cheaper source fir raw materials. The aim of this work was to stody the feasibility of recycli ng High Density Polyethylene (HDPE). The mechanical, thermal and morphological properties of fresh Polypropylene (PP) alone and of its mixtures with fresh and degraded HDPE were analysed. The tensiles




Microsoft Academic Search

La formación continua de los trabajadores ocupados contribuye al reciclaje permanente y a la adquisición de nuevos conocimientos que les permite adaptarse a un entorno laboral y tecnológico en continuo cambio. Todo ello constituye un elemento fundamental para mejorar la competitividad de las empresas. El objetivo de este trabajo es realizar un estudio comparativo de la situación de España

González Flores; Ana Saiz Santos; Euskal Herriko Unibertsitatea


Con Artists Attack Colleges with Fake Help-Desk E-Mail  

ERIC Educational Resources Information Center

|An e-mail scam has hit tens of thousands of users at dozens of colleges over the past few weeks, leaving network administrators scrambling to respond before campus computer accounts are taken over by spammers. Students, professors, and staff members at the affected colleges received e-mail messages that purported to come from the colleges' help…

Young, Jeffrey R.




Microsoft Academic Search

Non-alcoholic fatty liver is a common disease closely related to the increasing prevalence of obesity and type 2 diabetes in the general population. The eSS rats display a non obese type 2 diabetic syndrome with an insulin resistant state characterized by hyperglycaemia, hypertriglyceridemia and hyperinsulinemia. In 12 month-old eSS males glycaemia, fructosamine, triglyceridemia and reactive species to oxygen were evaluated,

Stella Maris Daniele; Juan Carlos Picena; Silvana Marisa Montenegro; María Cristina Tarrés; Stella Maris Martínez



Microsoft Academic Search

Not only is surface water quality affected by the disposal of polluted residues, but also groundwater quality can be deteriorated by the transport of contaminants through soil. A mining residue contaminated site was selected from the Guadiamar River watershed, in order to establish the residual levels of pollution after the restoration labors, and the potential heavy metal mobility through the

M. J. Polo Gómez; E. Domínguez García-Baquero; J. V. Giráldez Cervera



Microsoft Academic Search

Meat industry is highly interested in developing low-fat meat emulsions, without modifying the organoleptic and textural attributes of the final product. The aim of this work was to determine the feasibility of employing freeze-dried surimi obtained from Tilapia nilotica as a functional additive in the formulation of low-fat frankfurters. Model systems of meat emulsions were obtained with two levels of

J. A. Ramírez; M. Vázquez; Lago de Chapala



Modelling reproductive allocation of dusky salamanders using optimal control theory: Pros, cons and caveats  

Microsoft Academic Search

Summary  Optimal control theory has been used to examine the evolution of life history characters in a variety of plant and animal species. In this paper, I examine control theoretic models of reproductive allocation in female dusky salamanders and consider some practical aspects of modelling, including the appropriateness of nonlinear formulations, methods for describing semelparous reproduction, and data needed to parameterize

Carole L. Hom



Using elliptical copulas to model spatial dependence in regional frequency analysis : pros and cons.  

NASA Astrophysics Data System (ADS)

At-site frequency analysis of hydrological extremes (rainfall and runoff) is affected by considerable uncertainty, due to the strong natural variability of extremes and the comparatively short record length. Regional frequency analysis aims to reduce this uncertainty by conjointly analyzing several sites from a homogeneous hydrologic region. In most cases, regional frequency analysis is based on the "index flood" hypothesis: data from all sites are assumed to be realizations from an identical regional distribution, after dividing at-site data by a suitable scale factor (e.g., the at-site median). This regional distribution can then be estimated using data from all sites. However, data are in general spatially dependent. This intersite dependence may bias the inference when ignored. In this presentation, spatial dependence is explicitly modeled using the family of elliptical copulas, whose properties are well suited to model dependence in high-dimensional spatial problems. Copulas from this family are parameterized by a dependence matrix, whose elements quantify pairwise dependences. The strength of dependence can be assumed to be a function of the intersite distance, thus leading to a natural analogy with methods used in standard geostatistics. Members of the elliptical family differ by their treatment of asymptotic dependence. For instance, the Gaussian copula assumes asymptotically independent data, while the Student t-copula quantifies asymptotic dependence using an additional parameter. A case study, based on annual maxima of rainfall from sites in the French Mediterranean region, is carried out to evaluate the impact of spatial dependence on regional frequency analysis. In a first step, we evaluate the sensitivity of parameter estimates (e.g., location, scale and shape parameters of a regional Generalized Extreme Value distribution) to the treatment of spatial dependence. Results show that: (i) ignoring the existence of spatial dependence significantly affects parameter estimates. In particular, it leads to an under-estimation of uncertainties. (ii) In comparison, the treatment of asymptotic dependence is of second-order importance, with similar estimates being found with a Gaussian or a Student t- copula. In a second step, we evaluate the robustness of the framework to estimate the probability of rare spatial events. To this aim, we estimate the probability that several sites exceed high threshold values during the same year. Results demonstrate that such estimates are far more sensitive to the treatment of asymptotic dependence, with different estimates being found with a Gaussian or a Student t- copula. This implies that the choice of a copula (in particular, its treatment of asymptotic dependence) is of prime importance, and has to be based on strong empirical or physical evidence. In the absence of that, there is no guarantee that estimates of spatial events are meaningful, especially in the extrapolation domain.

Renard, Benjamin



Biomedical Engineering as a Major within Electrical Engineering and Information Technology - Pros and Cons  

Microsoft Academic Search

\\u000a At the University of Karlsruhe Biomedical Engineering (BME) is still a field of specialization within the master program of\\u000a Electrical Engineering and Information Technology (EEIT) and not a focussed BME master program. This program contains more\\u000a basics and methods of EEIT as compared to a full BME master program. On the other hand the spectrum of BME contents is reduced.

O. Dössel


Estilos educativos materno y paterno: Evaluación y relación con el ajuste adolescente  

Microsoft Academic Search

Title: Maternal and paternal parenting styles: assessment and relationship with adolescent adjustment. Abstract: This study presents the validation of a scale that was elaborated to assess maternal and paternal parenting styles according to the percep- tion of their adolescent children. The scale was applied to a sample com- posed by 848 adolescents aged from 12 to 17 years old, that

Alfredo Oliva Delgado; Águeda Parra Jiménez; Inmaculada Sánchez-Queija; Francisca López Gaviño



(Why) Should We Use SEM? Pros and Cons of Structural Equation Modeling  

Microsoft Academic Search

During the last two decades, Structural Equation Modeling (SEM) has evolved from a statistical technique for insiders to an established valuable tool for a broad scientific public. This class of analyses has much to offer, but at what price? This paper pro- vides an overview on SEM, its underlying ideas, potential applications and current software. Furthermore, it discusses avoidable pitfalls

Christof Nachtigall; Ulf Kroehne; Friedrich Funke; Rolf Steyer


Speaking for Others: The Pros and Cons of Group Advocates using Collective Language  

Microsoft Academic Search

We examined how rhetorical style affects evaluations of group advocates, and how these evaluations are moderated by group identification. University students were given a letter to the editor defending student welfare. The argument was either constructed using personal language (‘I believe’) or collective language (‘we believe’). Furthermore, the letter was either attributed to an official advocate (president of the student

Matthew J. Hornsey; Leda Blackwood; Anne O’brien



The Pros and Cons of a Single `Euro-Price' For Drugs  

Microsoft Academic Search

Parallel trade in pharmaceuticals has become a major European Union policy issue with several `solutions' being considered by the European Commission, Member State governments and the pharmaceutical industry in the `Bangemann Process'. This paper discusses the issues from an economic and public policy perspective - considering the economic cases for differential pricing and for `Euro-prices', concluding that the economic case

Adrian Towse




Microsoft Academic Search

One of the most striking features of the modern history of world trade is that over the last fifty years, there has been a tremendous growth in the volume of world trade, the pace of which is quite unprecedented in human history. From ???? to ????, for example, the value of world trade, measured in U.S. dollars, increased nearly tenfold.

Pham Chi Thanh


La micorrizazione di alcuni cloni micropropagati di Populus alba L. con Tuber magnatum Pico  

Microsoft Academic Search

Mycorrhization of some micropropagated clones of Populus alba L. with Tuber magnatum Pico. - Plants micropropagated from clones of white poplar (Populus alba L.) were mycorrhized with Tuber magnatum Pico using three inoculation techniques: the sporal suspension method, the method of putting mycorrhized root framgments in contact with roots of plants to be mycorrhized and the method of root transmission

P. Angelini; B. Granetti



Hybrid and Disposable Facilities for Manufacturing of Biopharmaceuticals: Pros and Cons  

NASA Astrophysics Data System (ADS)

Modern biotechnology has grown over the last 35 years to a maturing industry producing and delivering high-value biopharmaceuticals that yield important medical and economical benefits. The constantly increasing need for biopharmaceuticals and significant costs related to time-consuming R&D work makes this industry risky and highly competitive. This trend is confirmed by the important number of biopharmaceuticals that are actually under development at all stages by all major pharmaceutical industry companies. A consequence of this evolution is an increasing need for development and manufacturing capacity. The build up of traditional - stainless steel - technology is complicated, time consuming and very expensive. The decision for such a major investment needs to be taken early in the development cycle of a promising drug to cope with future demands for clinical trials and product launch. Possibilities for the reduction of R&D and manufacturing costs are therefore of significant interest in order to be competitive.

Ravisé, Aline; Cameau, Emmanuelle; de Abreu, Georges; Pralong, Alain



Microsoft Academic Search

There is a public and professional debate on the usefulness of alcohol warning labels. This paper presents the major arguments in favor and against such labeling in the context of alcohol use in pregnancy. lcohol warning labels were initially introduced in 1989 to provide the public with repetitive reminders of the teratogenic potential of alcohol use. There are strong arguments

Daniela Caprara; Offie Soldin; Gideon Koren




Microsoft Academic Search

Nutritional value of Transvala hay inoculated with the mushroom Pleurotus ostreatus. Nutritional value of hay used to produce the edible mushroom Pleurotus ostreatus was analyzed. Hay samples taken before and after inoculation with the mushroom were analyzed for their dry matter (DM), crude protein (CP), ethereal extract (EE), ash (Ce), in vitro dry matter digestibility (IVDMD), no fiber carbohydrates (NFC),

Giselle Alvarado Retana


ReConMUC - Adaptable Consistency Requirements for Efficient Large-scale Multi-user Chat  

Microsoft Academic Search

Multi-user chat (MUC) applications raise serious challenges to developers concerning scalability and efficient use of net- work bandwidth, due to a large number of users exchanging lots of messages in real-time. We propose a new approach to MUC message propagation based on an adaptable consistency model bounded by three metrics: Filter, Time and Volume. In this model, the server propagates

Pedro Alves



Inconsistencias en la seguridad nacional de Vicente Fox y la relacion con Estados Unidos  

Microsoft Academic Search

The central argument of this dissertation is to examine how the political regime which emerged from the Mexican Revolution confused its own security with the security of the Nation-State between 1928 and the year 2000. Nevertheless, that was the type of relationship supported by Washington because it helped to preserve its own interests of stability and security in its Southern

Abelardo Rodriguez Sumano



Informes y Trabajo sobre la Comunicacion con las Masas (Reports and Papers on Mass Communication).  

National Technical Information Service (NTIS)

These are guides to low cost, grass roots techniques to accomplish extension related activities. (1) Rural Mimeo Newspapers provides a low cost method for newspaper production from the news gathering process, to lay-out and printing, to sales and distribu...



Interés del Ultrasonido con Doppler de Potencia en el Seguimiento de la Artritis Reumatoídea  

Microsoft Academic Search

Summary The use of musculoskeletal ultrasound with power Doppler in the evaluation of arthritis has already demons- trated its importance. Its use to check steroid injections can help us improve the management of arthritis. We describe the case of a woman with rheumatoid arthritis, which was controlled using methotrexate and prednisone until 6 months ago, when she presented a persistent



Pros and cons of apomorphine and L-dopa continuous infusion in advanced Parkinson's disease.  


Motor fluctuations and dyskinesia are common in advanced Parkinson's disease and can be poorly managed by current oral medications. Risk factors include the amount of L-dopa administered, gender and patient age. Continuous duodenal L-dopa or subcutaneous apomorphine infusions are helpful strategies because they can control motor complications by providing continuous dopaminergic drug delivery. Apomorphine subcutaneous infusion provides a motor benefit similar to that of dopamine and is relatively easy to use in advanced PD. However, it commonly requires concomitant administration of oral L-dopa and its long-term use is limited by compliance. Continuous administration of L-dopa/carbidopa by infusion in the duodenum/jejunum is a more complex procedure requiring a gastrostomy for the placement of the infusion tube, but it allows replacement of all oral medications and the achievement of a satisfactory therapeutic response paralleled by a reduction of motor complication severity. It should be noted that although these procedures are effective, most evidence relates to small case series and, particularly in the case of apomorphine, despite its long-term availability, there is a complete lack of randomized blinded studies. In addition, unlike deep brain stimulation, it is unclear which patients are the best candidates for these procedures, making any indirect comparison very complex, given the clinical heterogeneity of reported patients. This has consequences in resource allocation and in estimating cost-benefit ratios for these complex therapies in advanced PD. PMID:20123567

Antonini, Angelo; Odin, Per




Microsoft Academic Search

The effect of 20 % washed mechanically deboned chicken meat (WM) as a substitute of breast meat (HDCM) on chicken nuggets characteristics during frozen storage was investigated. Two different formulations were made, one with 100 % HDCM, the other with 20 % WM as a substitute for HDCM. WM was produced by washing mechanically deboned chicken meat, 3 steps of

G. Teira; R. Fabre; S. Kueider



Pros and cons of colonoscopy in management of acute lower gastrointestinal bleeding  

PubMed Central

Acute lower gastrointestinal bleeding (LGIB) is a frequent gastrointestinal cause of hospitalization, particularly in the elderly, and its incidence appears to be on the rise. Endoscopic and radiographic measures are available for the evaluation and treatment of LGIB including flexible sigmoidoscopy, colonoscopy, angiography, radionuclide scintigraphy and multi-detector row computed tomography. Although no modality has emerged as the gold standard in the management of LGIB, colonoscopy is the current preferred initial test for the majority of the patients presenting with hematochezia felt to be from a colon source. Colonoscopy has the ability to diagnose all sources of bleeding from the colon and, unlike the radiologic modalities, does not require active bleeding at the time of the examination. In addition, therapeutic interventions such as cautery and endoclips can be applied to achieve hemostasis and prevent recurrent bleeding. Studies suggest that colonoscopy, particularly when performed early in the hospitalizatio