Sample records for lagrange park il

  1. International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)

    E-print Network

    Danon, Yaron

    2009-01-01

    International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009.P. Barry Department of Mechanical Aerospace and Nuclear Engineering, Rensselaer Polytechnic Institute 110 8

  2. International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)

    E-print Network

    Danon, Yaron

    2009-01-01

    International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009 and Nuclear Engineering Troy, New York, 12180 D.P. Barry, G. Leinweber, N.J. Drindak (ret.), J.G. Hoole Knolls

  3. 75 FR 3253 - Lamb Assembly and Test, LLC, Subsidiary of Mag Industrial Automation Systems, Machesney Park, IL...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ...DEPARTMENT OF LABOR Employment and Training Administration [TA-W-70,516] Lamb Assembly and Test, LLC, Subsidiary of Mag Industrial Automation Systems, Machesney Park, IL; Notice of Negative Determination Regarding Application for...

  4. 5. Wick, O. J. (ed.) Plutonium Handbook: a Guide to the Technology 3357 (American Nuclear Society, LaGrange Park, IL, 1980).

    E-print Network

    Dinsmore, Tony

    5. Wick, O. J. (ed.) Plutonium Handbook: a Guide to the Technology 33­57 (American Nuclear Society superconductors. Phys. Rev. Lett. 8, 250­253 (1962). 11. Wolfer, W. G. Radiation effects in plutonium. Los Alamos

  5. The Lagrange Points

    ERIC Educational Resources Information Center

    Lovell, M.S.

    2007-01-01

    This paper presents a derivation of all five Lagrange points by methods accessible to sixth-form students, and provides a further opportunity to match Newtonian gravity with centripetal force. The predictive powers of good scientific theories are also discussed with regard to the philosophy of science. Methods for calculating the positions of the…

  6. Lagrange programming neural networks

    Microsoft Academic Search

    Shengwei Zhang; A. G. Constantinides

    1992-01-01

    A class of neural networks appropriate for general nonlinear programming, i.e., problems including both equality and inequality constraints, is analyzed in detail. The methodology is based on the Lagrange multiplier theory in optimization and seeks to provide solutions satisfying the necessary conditions of optimality. The equilibrium point of the network satisfies the Kuhn-Tucker condition for the problem. No explicit restriction

  7. Multipliers Math 1920 Lagrange Multiplier Pictures

    E-print Network

    Back, Allen

    Math 1920 Lagrange Multiplier Pictures V1 Lagrange Multipliers Math 1920 Lagrange Multiplier Pictures Dr. Back Sep. 23, 2009 #12;Math 1920 Lagrange Multiplier Pictures V1 Lagrange Multipliers Please Multiplier Pictures V1 Lagrange Multipliers Maximize f (x, y) = yex . On the constraint set x2 + xy + 4y2 = 1

  8. The Lagrange-mesh method

    NASA Astrophysics Data System (ADS)

    Baye, Daniel

    2015-03-01

    The Lagrange-mesh method is an approximate variational method taking the form of equations on a grid thanks to the use of a Gauss-quadrature approximation. The variational basis related to this Gauss quadrature is composed of Lagrange functions which are infinitely differentiable functions vanishing at all mesh points but one. This method is quite simple to use and, more importantly, can be very accurate with small number of mesh points for a number of problems. The accuracy may however be destroyed by singularities of the potential term. This difficulty can often be overcome by a regularization of the Lagrange functions which does not affect the simplicity and accuracy of the method. The principles of the Lagrange-mesh method are described, as well as various generalizations of the Lagrange functions and their regularization. The main existing meshes are reviewed and extensive formulas are provided which make the numerical calculations simple. They are in general based on classical orthogonal polynomials. The extensions to non-classical orthogonal polynomials and periodic functions are also presented. Applications start with the calculations of energies, wave functions and some observables for bound states in simple solvable models which can rather easily be used as exercises by the reader. The Dirac equation is also considered. Various problems in the continuum can also simply and accurately be solved with the Lagrange-mesh technique including multichannel scattering or scattering by non-local potentials. The method can be applied to three-body systems in appropriate systems of coordinates. Simple atomic, molecular and nuclear systems are taken as examples. The applications to the time-dependent Schrödinger equation, to the Gross-Pitaevskii equation and to Hartree-Fock calculations are also discussed as well as translations and rotations on a Lagrange mesh.

  9. A Note on Lagrange's Theorem.

    ERIC Educational Resources Information Center

    Johnson, Wells

    1983-01-01

    An approach to teaching the proof of Lagrange's theorem reverses the traditional path of instruction. The route described first teaches that the order of an element always divides the order of the group, then moves to proving that the order of a subgroup divides the order of the group. (MP)

  10. Dark universe with Lagrange multipliers

    NASA Astrophysics Data System (ADS)

    Cid, Antonella; Labrana, Pedro

    2015-03-01

    Cosmological models with Lagrange multipliers are appealing because they could explain the behaviour of the dark sector in a unified way, in this sense dark matter and dark energy are two limits of a single fluid which describes the late behaviour of our universe at large scales. In this work we analyze extensions to the "Dust of Dark Energy model" proposed in JCAP 1005,012(2010) by including spatial curvature and more general potentials of the scalar field. We perform a dynamical system study and we present bayesian statistical analysis for the model using supernovae type Ia and H(z) data.

  11. Parks Research

    NSDL National Science Digital Library

    Mrs. Guy

    2013-10-05

    Research your park and convince me it is the best one. Choose your park and find at least 7 GREAT facts !!! Denali National Park Grand Canyon National Park Great Smoky Mountains National Park Mount Rainier National Park Olympic National Park Rocky Mountain National Park Yellowstone National Park Yosemite National Park Zion National Park Zion National Park 2 ...

  12. International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)

    E-print Network

    Benzi, Michele

    2009-01-01

    . For a quadrature set denoted by [^n, wn] with 1 n N, total cross-section , scattering cross-section s, and knownInternational Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009

  13. International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)

    E-print Network

    Vialle, Stéphane

    2009-01-01

    operator such as EDF, the time required to compute nuclear reactor core simulations is rather critical. Introduction As operator of nuclear power plants, EDF needs many nuclear reactor core simulationsInternational Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009

  14. American Nuclear Society 2013 Student Conference Massachusetts Institute of Technology Boston, Massachusetts, USA, April 4-6, 2013, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2013)

    E-print Network

    Danon, Yaron

    2013-01-01

    in their results. Lower uncertainty allows for tighter safety margins, which is paramount in scenarios where space as a pulsed source of neutrons with a white spectrum of energies, which travel along a 40 meter evacuated

  15. PHYSOR 2004 -The Physic of Fuel Cycles and Advanced Nuclear Systems: Global Developments Chicago, Illinois, April 25-29, 2004, on CD-ROM, American Nuclear Society, Lagrange Park, IL. (2004)

    E-print Network

    Paris-Sud XI, Université de

    2004-01-01

    especially for the breeding ratio. The Molten Salt Breeder Reactor project was based on an intensive three typical scenarios, based on three reactor types: Pressurized Water Reactor, Fast Neutron Reactor Molten Salt Reactor can be realistic, with correct temperature coefficients and at least iso-breeder

  16. Confined helium on Lagrange meshes

    E-print Network

    Daniel Baye; Jérémy Dohet-Eraly

    2015-06-01

    The Lagrange-mesh method has the simplicity of a calculation on a mesh and can have the accuracy of a variational method. It is applied to the study of a confined helium atom. Two types of confinement are considered. Soft confinements by potentials are studied in perimetric coordinates. Hard confinement in impenetrable spherical cavities is studied in a system of rescaled perimetric coordinates varying in [0,1] intervals. Energies and mean values of the distances between electrons and between an electron and the helium nucleus are calculated. A high accuracy of 11 to 15 significant figures is obtained with small computing times. Pressures acting on the confined atom are also computed. For sphere radii smaller than 1, their relative accuracies are better than $10^{-10}$. For larger radii up to 10, they progressively decrease to $10^{-3}$, still improving the best literature results.

  17. Confined helium on Lagrange meshes

    E-print Network

    Baye, Daniel

    2015-01-01

    The Lagrange-mesh method has the simplicity of a calculation on a mesh and can have the accuracy of a variational method. It is applied to the study of a confined helium atom. Two types of confinement are considered. Soft confinements by potentials are studied in perimetric coordinates. Hard confinement in impenetrable spherical cavities is studied in a system of rescaled perimetric coordinates varying in [0,1] intervals. Energies and mean values of the distances between electrons and between an electron and the helium nucleus are calculated. A high accuracy of 11 to 15 significant figures is obtained with small computing times. Pressures acting on the confined atom are also computed. For sphere radii smaller than 1, their relative accuracies are better than $10^{-10}$. For larger radii up to 10, they progressively decrease to $10^{-3}$, still improving the best literature results.

  18. Pay Parking Permit Parking

    E-print Network

    Buildings Parkings Pay Parking Permit Parking Information(student) Legend Information(security) BusTower Building Richard Bolton Park Halpern Centre . CS e W.A.C . Bennett Library Campus Security Academic #2 Field #3 Field #4Townhouse Complex AQ NAHEENO PARK DISCO VERY RESEARCH PARK RESIDENCES ARTS

  19. Classical Lagrange Functions for the SME

    E-print Network

    Neil Russell

    2010-09-07

    A technique is presented for finding the classical Lagrange function corresponding to a given dispersion relation. This allows us to study the classical analogue of the Standard-Model Extension. Developments are discussed.

  20. Fenchel and Lagrange Duality are Equivalent

    E-print Network

    Magnanti, Thomas L.

    A basic result in ordinary (Lagrange) convex programming is the saddlepoint duality theorem concerning optimization problems with convex inequalities and linear-affine equalities satisfying a Slater condition. This note ...

  1. Parking Information Center Student Parking

    E-print Network

    de Lijser, Peter

    CP DBH MH CPAC TSU NPS SCPS B E CS PL VA H UH LH ECS KHS TG RH SH RGC GF SHCC TH EC G Parking Information Center Buildings Student Parking Faculty/Staff Parking Parking Permit Machine Park and Pay QUAD FULLERTON ARBORETUM TITAN SPORTS COMPLEX F PARKING E PARKING CPFS PARKING A PARKING A-South PARKING G

  2. An Extension of Lagrange's Identity to Matrices. Classroom Notes

    ERIC Educational Resources Information Center

    Trenkler, Gotz

    2004-01-01

    In this note the well-known Lagrange identity is extended to matrices. The resulting generalized Lagrange identity is used to give characterizations of symmetry, commutativity of projectors and normality.

  3. Parking Regulations PARKING POLICY STATEMENT

    E-print Network

    Richards-Kortum, Rebecca

    1 Parking Regulations PARKING POLICY STATEMENT: 1. All employees and students of Rice University who park on campus are required to register their motor vehicles with the Rice Parking Office or park in designated *paid visitor parking facilities. 2. All visitors park in *visitor parking. 3. Only areas marked

  4. Car Park 31 Car Park 23

    E-print Network

    Tobar, Michael

    Car Park 31 CarPark30 Car Park 1 Car Park 2 Car Park 23 Car Park 20 CarPark19 Car Park 29 Car Park 17 Car Park 16 Car Park 3 CarPark35 CarPark15 Car Park 14 Car Park 9 Car Park 33 CarPark6 CarPark5 Car Park 18 Car Park 10 Car Park 7 CaCa 8rkCCCCC PaPa kkCaCarrr P Car Park 8 Car Park 8 CarPark 21 Car

  5. PARKING & TRANSPORTATION SERVICES Student Parking

    E-print Network

    Hofmann, Hans A.

    PARKING & TRANSPORTATION SERVICES Student Parking 12/13 PARKING & TRANSPORTATION SERVICES #12;Student ParkingStudent Parking at a rate of $10/month by the PTS main office upon receipt of a letter. Alternative parking is provided for "D"permit holders unable to locate a space in the area preferred

  6. PARKING & TRANSPORTATION SERVICES Student Parking

    E-print Network

    Johnston, Daniel

    PARKING & TRANSPORTATION SERVICES Student Parking 13/14 PARKING & TRANSPORTATION SERVICES #12;Student ParkingStudent Parking at a rate of $10/month by the PTS main office upon receipt of a letter. Alternative parking is provided for "D"permit holders unable to locate a space in the area preferred

  7. Fractional variations for dynamical systems: Hamilton and Lagrange approaches

    Microsoft Academic Search

    Vasily E. Tarasov

    2006-01-01

    Fractional generalization of an exterior derivative for calculus of variations is defined. The Hamilton and Lagrange approaches are considered. Fractional Hamilton and Euler–Lagrange equations are derived. Fractional equations are obtained by fractional variation of Lagrangian and Hamiltonian that have only integer derivatives.

  8. LAGRANGE-D'ALEMBERT SPARK INTEGRATORS FOR NONHOLONOMIC LAGRANGIAN SYSTEMS

    E-print Network

    Jay, Laurent O.

    LAGRANGE-D'ALEMBERT SPARK INTEGRATORS FOR NONHOLONOMIC LAGRANGIAN SYSTEMS LAURENT O. JAY Abstract Runge-Kutta (SPARK) methods for index 2 DAEs satisfies the new discrete principle. Symmetric Lagrange-d'Alembert SPARK integrators of any order can be obtained based for example on Gauss and Lobatto coefficients

  9. LAGRANGED'ALEMBERT SPARK INTEGRATORS FOR NONHOLONOMIC LAGRANGIAN SYSTEMS

    E-print Network

    Jay, Laurent O.

    LAGRANGE­D'ALEMBERT SPARK INTEGRATORS FOR NONHOLONOMIC LAGRANGIAN SYSTEMS LAURENT O. JAY # Abstract Runge­Kutta (SPARK) methods for index 2 DAEs satisfies the new discrete principle. Symmetric Lagrange­d'Alembert SPARK integrators of any order can be obtained based for example on Gauss and Lobatto coe

  10. IL-12/IL-23 Salmonella

    E-print Network

    Schüler, Axel

    Keywords Immunity IL-12/IL-23 Salmonella Cryptococcus » Prof. Dr. Gottfried Alber Interleukin.; Kastelein, r. a.; alBer, G. Protective immunity to systemic infection with attenuated Salmonella enterica se

  11. LAGRANGE - the new neutron vibrational spectrometer at the ILL

    NASA Astrophysics Data System (ADS)

    Jiménez-Ruiz, Mónica; Ivanov, Alexander; Fuard, Stephane

    2014-11-01

    The new neutron vibrational spectrometer LAGRANGE replaces the Be filter spectrometer placed on the hot source at the Institut Laue-Langevin. Lagrange provides much higher sensitivity to extremely small or low scattering samples through substantially increased detector count rate combined with considerably improved energy resolution. It opens new possibilities for the spectroscopic studies of complex materials. The new instrument permits investigation of much smaller samples, inherent in novel materials studies, recording of well- resolved vibration spectra. Lagrange is fully operational for users since 2012.

  12. PARKING & TRANSPORTATION SERVICES Faculty & Staff ParkingFaculty & Staff Parking

    E-print Network

    Hofmann, Hans A.

    PARKING & TRANSPORTATION SERVICES Faculty & Staff ParkingFaculty & Staff Parking 12/13 PARKING & TRANSPORTATION SERVICES #12;Faculty & Staff ParkingFaculty & Staff Parking at a rate of $12/month by the PTS main is often congested, making commuting and parking difficult. Understanding your parking and transportation

  13. Superconvergence of bi- k-Lagrange elements for eigenvalue problems

    NASA Astrophysics Data System (ADS)

    Li, Z.-C.; Chien, C.-S.; Huang, H.-T.; Jeng, B.-W.

    2009-11-01

    We study superconvergence of bi-k-Lagrange elements for parameter-dependent problems where k ? 2. We show that the superconvergence rate of the bi-k-Lagrange elements is two orders higher than that of the kth-order Lagrange elements. This is a significant improvement of the previous results [C.-S. Chien, H.T. Huang, B.-W. Jeng, Z.C. Li, Superconvergence of FEMs and numerical continuation for parameter-dependent problems with folds, Int. J. Bifurcation Chaos 18 (2008) 1321-1336], which is only one order (or a half order) higher than that of the latter. Next, we apply the bi-k-Lagrange elements to the computations of energy levels and wave functions of two-dimensional (2D) Bose-Einstein condensates (BEC), and BEC in a periodic potential. Sample numerical results are reported.

  14. LAGRANGE: LAser GRavitational-wave ANtenna at GEo-lunar Lagrange points

    E-print Network

    Conklin, J W; Aguero, V; Alfauwaz, A; Aljadaan, A; Almajed, M; Altwaijry, H; Al-Saud, T; Balakrishnan, K; Byer, R L; Bower, K; Costello, B; Cutler, G D; DeBra, D B; Faied, D M; Foster, C; Genova, A L; Hanson, J; Hooper, K; Hultgren, E; Jaroux, B; Klavins, A; Lantz, B; Lipa, J A; Palmer, A; Plante, B; Sanchez, H S; Saraf, S; Schaechter, D; Sherrill, T; Smith, E; Shu, K -L; Tenerelli, D; Vanbezooijen, R; Vasudevan, G; Williams, S D; Worden, S P; Zhou, J; Zoellner, A

    2011-01-01

    We describe a new space gravitational wave observatory design called LAGRANGE that maintains all important LISA science at about half the cost and with reduced technical risk. It consists of three drag-free spacecraft in the most stable geocentric formation, the Earth-Moon L3, L4, and L5 Lagrange points. Fixed antennas allow continuous contact with the Earth, solving the problem of communications bandwidth and latency. A 70 mm diameter AuPt sphere with a 35 mm gap to its enclosure serves as a single inertial reference per spacecraft, which is operated in "true" drag-free mode (no test mass forcing). This is the core of the Modular Gravitational Reference Sensor whose other advantages are: a simple caging design based on the DISCOS 1972 drag-free mission, an all optical read-out with pm fine and nm coarse sensors, and the extensive technology heritage from the Honeywell gyroscopes, and the DISCOS and Gravity Probe B drag-free sensors. An Interferometric Measurement System, designed with reflective optics and a...

  15. Sylvester's Minorant Criterion, Lagrange-Beltrami Identity, and Nonnegative Definiteness

    E-print Network

    Sudhir R. Ghorpade; Balmohan V. Limaye

    2007-07-19

    We consider the characterizations of positive definite as well as nonnegative definite quadratic forms in terms of the principal minors of the associated symmetric matrix. We briefly review some of the known proofs, including a classical approach via the Lagrange-Beltrami identity. For quadratic forms in up to 3 variables, we give an elementary and self-contained proof of Sylvester's Criterion for positive definiteness as well as for nonnegative definiteness. In the process, we obtain an explicit version of Lagrange-Beltrami identity for ternary quadratic forms.

  16. OSU PARKING UTILIZATION NEIGHBORHOOD STREET PARKING

    E-print Network

    Escher, Christine

    OSU PARKING UTILIZATION STUDY AND NEIGHBORHOOD STREET PARKING STUDY FALL TERM 2010 FACILITIES SERVICES CAMPUS PLANNING #12;Facilities Services- Campus Planning February, 2011 2010 OSU PARKING .............................................................................................................................3 Parking Permits

  17. National Parks

    NSDL National Science Digital Library

    This online directory focuses on national parks throughout the country that offer educational opportunities. Where possible, it includes the following information for each: the type of support offered, including educational materials, access to a naturalist or specialists, and classes/workshops; and mailing address and contact information. In addition, a link to the National Park Service's Web site is included.

  18. Park It!

    ERIC Educational Resources Information Center

    Sartorius, Tara Cady

    2010-01-01

    Many artists visit national parks to draw, paint and take photographs of some of the most amazing scenery on earth. Raw nature is one of the greatest inspirations to an artist, and artists can be credited for helping inspire the government to create the National Park System. This article features Thomas Moran (1837-1926), one of the artists who…

  19. Generalized Lagrange criteria for certain quadratic Diophantine equations

    Microsoft Academic Search

    R. A. Mollin

    We consider the Diophantine equation of the form x2 ?Dy2 = ±4, where D is a positive integer that is not a perfect square, and provide a gener- alization of results of Lagrange with elementary proofs using only basic prop- erties of simple continued fractions. As a consequence, we achieve a completely general, simple criterion for the central norm to

  20. Pseudonormality and a Lagrange Multiplier Theory for Constrained Optimization

    Microsoft Academic Search

    D. P. Bertsekas; A. E. Ozdaglar

    2002-01-01

    We consider optimization problems with equality, inequality, and abstract set constraints, and we explore various characteristics of the constraint set that imply the existence of Lagrange multipliers. We prove a generalized version of the Fritz–John theorem, and we introduce new and general conditions that extend and unify the major constraint qualifications. Among these conditions, two new properties, pseudonormality and quasinormality,

  1. Formation Control of Marine Surface Craft using Lagrange Multipliers

    E-print Network

    Sontag, Eduardo

    mechanical systems, ships, aircraft, unmanned vehicles, spacecraft, etc., have been the object of recentFormation Control of Marine Surface Craft using Lagrange Multipliers Ivar-André F. Ihle1, Jérôme in the development of powerful control techniques for single vehicles, the increasing computation and communication

  2. TwilightTwilight phenomenaphenomena of Venusof Venus Laboratoire Lagrange

    E-print Network

    Widemann, Thomas

    TwilightTwilight phenomenaphenomena of Venusof Venus P. Tanga Laboratoire Lagrange Observatoire de ­ Paris, March 6 2012 #12;Paolo Tanga ­The aureole of Venus Sakura/Europlanet Workshop ­ Paris, March 6°.5 Phase angle 177° Mallama et al. 2006 #12;Paolo Tanga ­The aureole of Venus Sakura/Europlanet Workshop

  3. Apuntes de clase1 MECANICA DE FLUIDOS. COORDENADAS DE LAGRANGE

    E-print Network

    Tradacete, Pedro

    conceptos b´asicos. · Axiomas de la mec´anica de medios continuos. · Descripciones de Euler y Lagrange, 3). El medio esta compuesto de particulas puntuales = el concepto de medio continuo es una abstracci´on. La teoria falla a niveles microsc´opicos, sino viene confirmada experiman- talmemte a niveles macrosc

  4. La R\\'esolvante de Lagrange et ses Applications

    E-print Network

    Valibouze, Annick

    2009-01-01

    In this paper, the changes of representations of a group are used in order to describe its action as algebraic Galois group of an univariate polynomial on the roots of factors of any Lagrange resolvent. By this way, the Galois group of resolvent factors are pre-determinated. In follows, different applications are exposed; in particular, some classical results of algebraic Galois theory.

  5. EULER-LAGRANGE CHANGE OF VARIABLES IN CONSERVATION LAWS

    E-print Network

    Boyer, Edmond

    EULER-LAGRANGE CHANGE OF VARIABLES IN CONSERVATION LAWS YUE-JUN PENG Laboratoire de Math@math.univ-bpclermont.fr Abstract : We introduce a new method for studying the Cauchy problem for systems of conservation laws-Infeld equations. An explicit formula of its entropy solution is also provided. Keywords. Conservation laws, change

  6. Sixth American Nuclear Society International Topical Meeting on Nuclear Plant Instrumentation, Control, and Human-Machine Interface Technologies NPIC&HMIT 2009, Knoxville, Tennessee, April 5-9, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL

    E-print Network

    Heljanko, Keijo

    power plants, novel digitalized I&C systems have brought out new needs for safety evaluation investigates the verification of a power plant related safety logic system which combines real-time aspects of large systems. The safety logic system was modeled using NuSMV and Uppaal and the model checking

  7. Sixth American Nuclear Society International Topical Meeting on Nuclear Plant Instrumentation, Control, and Human-Machine Interface Technologies NPIC&HMIT 2009, Knoxville, Tennessee, April 5-9, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL

    E-print Network

    Danon, Yaron

    Sixth American Nuclear Society International Topical Meeting on Nuclear Plant Instrumentation the need for additional non proliferation safety measures. One of these safeguards is the tracking of 239 and create a nonlinear response to quantities of fissile materials. The system easily identified missing fuel

  8. Visitor Information Center Student Parking

    E-print Network

    de Lijser, Peter

    Center Buildings Student Parking Faculty/Staff Parking Parking Permit Machine $5 0406 QUAD FULLERTON ARBORETUM SPORTS COMPLEX F PARKING E PARKING CPFS PARKING A PARKING G PARKING S PARKING C PARKING I PARKING/Titan Shops Becker Amphitheater Children's Center Carl's Jr. College Park Corporation Yard Computer Science

  9. 78 FR 55219 - Safety Zone; Flying Machine Competition, Chicago, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ...RIN 1625-AA00 Safety Zone; Flying Machine Competition, Chicago, IL AGENCY: Coast...Michigan near Burnham Park during a flying machine competition event in Chicago, IL on September...Delegation No. 0170.1. An annual flying machine competition event has been scheduled...

  10. @central park

    NSDL National Science Digital Library

    The Central Park Conservancy, a not-for-profit organization dedicated to restoring, improving, and managing Central Park's grounds and facilities, offers this "official" site, which contains a wealth of information about what is arguably the world's most famous city park. Each of the site's sections contains useful or interesting information; the Then & Now section, for instance, offers an overview of Central Park's history, a bibliography with 43 entries for those seeking further information, and a list of movies with scenes set in the park. Another highlight of the site is the Virtual Park, which consists of a set of clickable maps through which users can explore 72 points of interest, each described in the affectionate style of a travel guidebook. The site's other sections include such features as events schedules, press releases, information on when and where particular varieties of flowers bloom, and a section devoted entirely to activities for families and children. This site will be especially useful to those who are planning a visit to Central Park, but other users will likely find it informative and entertaining as well.

  11. Information Valet Parking

    E-print Network

    Rose, Michael R.

    Information Directory Valet Parking Visitor Parking Emergency Parking Permit Parking Shuttle Stop Facilities Services 27 24 24A Imaging Services MSI 20 Parking Security33 Imaging Center Nikken Center 22B SeniorHealth Center Cardiovascular Center GCRC Medical Center Visitor Parking VisitorParking 73 Pavilion

  12. Augmented Lagrange Hopfield network for economic dispatch problems

    NASA Astrophysics Data System (ADS)

    Dieu, Vo Ngoc; Schegner, Peter; Ongsakul, Weerakorn

    2012-11-01

    This paper proposes augmented Lagrange Hopfield network (ALHN) for solving economic dispatch (ED) problems. The proposed ALHN is a new improvement of continuous Hopfield neural network by using augmented Lagrange function as its energy function. The ALHN is applied for solving different ED problems consisting of classical ED, ED with fuel constraint, ED with piecewise quadratic fuel cost, ED with prohibited operating zones, combined heat and power ED, and ED for hydrothermal systems. The proposed method has been tested on different systems and the obtained results are compared to those from other methods. The result comparison has shown that the proposed ALHN can obtain less total costs and faster computational times than many others. Therefore, ALHN could be a very powerful method for solving the ED problems.

  13. The unexplained accuracy of the Lagrange-mesh method.

    PubMed

    Baye, D; Hesse, M; Vincke, M

    2002-02-01

    The Lagrange-mesh method is an approximate variational calculation which resembles a mesh calculation because of the use of a Gauss quadrature. In order to analyze its accuracy, four different Lagrange-mesh calculations based on the zeros of Laguerre polynomials are compared with exact variational calculations based on the corresponding Laguerre basis. The comparison is performed for three solvable radial potentials: the Morse, harmonic-oscillator, and Coulomb potentials. The results show that the accuracies of the energies obtained for different partial waves with the different mesh approximations are very close to the variational accuracy, even in the presence of the centrifugal singularity. The same property holds for the approximate wave functions. This striking accuracy remains unexplained. PMID:11863688

  14. VISITOR PARKING MAP Visitor Pay Parking

    E-print Network

    North Carolina at Chapel Hill, University of

    VISITOR PARKING MAP Visitor Pay Parking Metered Parking Metered Motorcycle Parking Metered Visitor COMMUNITY SERVIC E BRANSO N STREET BUSINESS SCHOOL PARKING DECK KENAN CENTER KENAN- FLAGLER SCHOOL GYMNASIUM CARMICHAEL ARENA STUDENT RECREATION CENTER DANIELS STUDENT STORES HOUSE UNDER- GRAD. LIBRARY F. P

  15. Park Search

    NSDL National Science Digital Library

    Its never too early to begin planning your summer vacation, especially in the depths of winter; those with cabin fever can get a jump on their outdoor recreation plans at this site, provided by L.L. Bean. Users can search this database of over 1,400 state and national parks, forests, and wildlife refuges by state, region, and/or activities in which they are interested (including winter sports for all-season recreators). Search returns include contact information, an overview of the park/ forest and its highlights, photos, and a list of approved or available activities.

  16. Free Parking David Tarboton

    E-print Network

    Tarboton, David

    Free Parking David Tarboton Room 103 7973172 #12;2008 CH2 WEST STADIUM VILLA CLOSED BNR AG SCI ESLC ENG STL STL STANLAUBPRACTICE FACILITY 1 2 2 BBT 3 3 4 Student Parking Areas BLUE permit holders may park in any Blue or Yellow parking area. YELLOW permit holders may park in any Yellow parking area

  17. 16QAM Blind Equalization via Maximum Entropy Density Approximation Technique and Nonlinear Lagrange Multipliers

    PubMed Central

    Mauda, R.; Pinchas, M.

    2014-01-01

    Recently a new blind equalization method was proposed for the 16QAM constellation input inspired by the maximum entropy density approximation technique with improved equalization performance compared to the maximum entropy approach, Godard's algorithm, and others. In addition, an approximated expression for the minimum mean square error (MSE) was obtained. The idea was to find those Lagrange multipliers that bring the approximated MSE to minimum. Since the derivation of the obtained MSE with respect to the Lagrange multipliers leads to a nonlinear equation for the Lagrange multipliers, the part in the MSE expression that caused the nonlinearity in the equation for the Lagrange multipliers was ignored. Thus, the obtained Lagrange multipliers were not those Lagrange multipliers that bring the approximated MSE to minimum. In this paper, we derive a new set of Lagrange multipliers based on the nonlinear expression for the Lagrange multipliers obtained from minimizing the approximated MSE with respect to the Lagrange multipliers. Simulation results indicate that for the high signal to noise ratio (SNR) case, a faster convergence rate is obtained for a channel causing a high initial intersymbol interference (ISI) while the same equalization performance is obtained for an easy channel (initial ISI low). PMID:24723813

  18. An Application of Biregularity to Quaternionic Lagrange Interpolation

    Microsoft Academic Search

    A. Perotti

    2008-01-01

    We revisit the concept of totally analytic variable of one quaternionic variable introduced by Delanghe [1] and its application to Lagrange interpolation by Güerlebeck and Sprössig [2]. We consider left-regular functions in the kernel of the Cauchy-Riemann operator D = 2(??z1+j??z2) = ??x0+i??x1+j??x2-k??x3. For every imaginary unit p?S2, let Cp = ~=C and let Jp = p1J1+p2J2+p3J3 be the corresponding

  19. Convergence of a Substructuring Method with LaGrange Multipliers

    NASA Technical Reports Server (NTRS)

    Mandel, Jan; Tezaur, Radek

    1996-01-01

    We analyze the convergence of a substructuring iterative method with Lagrange multipliers, proposed recently by Farhat and Roux. The method decomposes finite element discretization of an elliptic boundary value problem into Neumann problems on the subdomains and a coarse problem for the subdomain nullspace components. For linear conforming elements and preconditioning by the Dirichlet problems on the subdomains, we prove the asymptotic bound on the condition number C(1 + log(H/h))(sup gamma), gamma = 2 or 3, where h is the characteristic element size and H is the subdomain size.

  20. Motorcycle and Moped Parking Map Moped Parking Only

    E-print Network

    Acton, Scott

    Motorcycle and Moped Parking Map Moped Parking Only Motorcycle and Moped Parking All motorcycles and mopeds are required to have a valid UVa Parking Permit to park in designated motorcycle and/or moped parking spaces. Motorcycles and Mopeds may also park in BLUE parking areas, such as the commuter parking

  1. POLICE, PARKING AND TRANSPORTATION Parking Services

    E-print Network

    Mohanty, Saraju P.

    " Staff/Faculty, "G" General, and "DP" Discovery Park (Car and Motorcycle) permits o Select the "Parking Staff Permit - $180.00 o "G" General Permit - $115.00 o "MC" Motorcycle Permit - $93.00 o "DP" Discovery Park lots 3 & 4 ­ $36.00 (Both car and Discovery Park motorcycle permits) · If you currently do

  2. Theodore Roosevelt National Park

    NSDL National Science Digital Library

    This National Park Service website contains information on: the park history; park activities such as hiking and camping; and natural history such as the wildlife, geology and paleontology of the park. The kids' section contains coloring pages, a park trivia quiz, reference sections on the wildlife and natural history of the park, and information on Theodore Roosevelt and his involvement in the Badlands. There are also images of the wildlife and scenery of the park.

  3. Prospect Park

    NSDL National Science Digital Library

    Prospect Park (New York, N.Y.)

    While many readers may be aware that trees grow in Brooklyn, few may be cognizant of the fact that, yes, a forest grows in Brooklyn. This urban forest just happens to be in the boroughâ??s own lovely Prospect Park, designed by those giants of landscape architects, Frederick Law Olmsted and Calvert Vaux. Often overlooked by some who are primarily concerned with that other large swath of green in the middle of Manhattan, Prospect Park contains a 90-acre meadow, a zoo, a celebrated performing arts festival, and a lake. Visitors to the Prospect Park Alliance website can learn all about these things, and also delve into the parkâ??s history. Those planning a visit may wish to look at the â??General Infoâ?ť and â??Places To Goâ?ť sections for a selection of brief descriptions and photographs. For those seeking a historical perspective the â??History & Natureâ?ť area is delightful. Here visitors can learn about the parkâ??s historical development and creation, and learn more about those individuals responsible for the parkâ??s design and aesthetic appeal. Finally, visitors should look at the online exhibit â??A Glimpse Of Prospect Parkâ?ť for a bit of visual perspective on the parkâ??s history.

  4. A Lagrange Multiplier and Hopfield-Type Barrier Function Method for the Traveling Salesman Problem

    Microsoft Academic Search

    Chuangyin Dang; Lei Xu

    2002-01-01

    A Lagrange multiplier and Hopéeld-type barrier function method is pro- posed for approximating a solution of the traveling salesman problem. The method is derived from applications of Lagrange multipliers and a Hopéeld-type barrier function and attempts to produce a solution of high quality by generating a minimum point of a barrier problem for a sequence of descending values of the

  5. Prime Field Multiplication in Adapted Modular Number System using Lagrange Representation

    E-print Network

    Paris-Sud XI, Université de

    Prime Field Multiplication in Adapted Modular Number System using Lagrange Representation a prime integer P, the Adapted Modular Number System. The multiplication in the AMNS consists of a multiplication of two polynomials and a AMNS-Carrying process. In this paper, we propose to use a Lagrange

  6. PARKING MAP // HOLIDAY INN

    E-print Network

    Martin, Jeff

    PARKING MAP // BALMORAL YOUNG LANGSIDE SPENCE GOOD ST. MARY ELLICE COLONY MEMORIAL COLONY VAUGHAN CENTRE UNIVERSITY OF WINNIPEG WINNIPEG CLINIC WALKING TRAFFIC ONLY PARKING LOT ENTRANCE ONE WAY PARKING LOT N AVAILABLE PARKING Underground, paid parking is available in the RecPlex. Surrounding surface

  7. Advice & Regulations for parking

    E-print Network

    Davies, Christopher

    Advice & Regulations for parking 2009-2010 C A M P U S PA RK I N G P L A N PARKING ZONES Pay and display, and permit zones are depicted on the Parking Plan overleaf. Westwood has Pay and Display parking of staff, other persons employed on campus, students resident off campus or visitors may park in the Pay

  8. 78 FR 2436 - Notice of Inventory Completion: Illinois State Museum, Springfield, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ...Inventory Completion: Illinois State Museum, Springfield, IL AGENCY: National Park...SUMMARY: The Illinois State Museum has completed an inventory of human remains...remains may contact the Illinois State Museum. Repatriation of the human remains...

  9. National Environmental Research Parks

    SciTech Connect

    Not Available

    1994-07-01

    The National Environmental Research Parks are outdoor laboratories that provide opportunities for environmental studies on protected lands that act as buffers around Department of Energy (DOE) facilities. The research parks are used to evaluate the environmental consequences of energy use and development as well as the strategies to mitigate these effects. They are also used to demonstrate possible environmental and land-use options. The seven parks are: Fermilab National Environmental Research Park; Hanford National Environmental Research Park; Idaho National Environmental Research Park; Los Alamos National Environmental Research Park; Nevada National Environmental Research Park; Oak Ridge National Environmental Research Park; and Savannah River National Environmental Research Park. This document gives an overview of the events that led to the creation of the research parks. Its main purpose is to summarize key points about each park, including ecological research, geological characteristics, facilities, and available databases.

  10. Fit of a Distribution Likelihood Function Likelihood Ratio Lagrange Multipliers Hanging Chi-Gram Goodness of Fit

    E-print Network

    Watkins, Joseph C.

    Fit of a Distribution Likelihood Function Likelihood Ratio Lagrange Multipliers Hanging Chi-Gram Likelihood Ratio Lagrange Multipliers Hanging Chi-Gram Outline Fit of a Distribution Blood Bank Likelihood Function Likelihood Ratio Lagrange Multipliers Hanging Chi-Gram 2 / 14 #12;Fit of a Distribution Likelihood

  11. Car Parking and Access Car Parking

    E-print Network

    Sussex, University of

    of vehicles are expected for an event, guidance and advice on producing a car parking management plan the campus at an early stage in the planning process, to check on the location of car parks and pedestrian, as part of such a visit. Where the University has deemed it necessary for a car parking management plan

  12. IL-4 EXACERBATES ANAPHYLAXIS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Studies were established to determine if IL-4, a cytokine critical for inducing allergic responses, contributes to the effector phase of allergy. Pretreatment of mice with IL-4 or the related cytokine, IL-13, rapidly and dramatically increased the severity of anaphylaxis induced by cross-linking Fc...

  13. IL-17 and infections.

    PubMed

    Ling, Y; Puel, A

    2014-10-01

    IL-17 immunity has been shown to be essential for mucocutaneous protection against Candida albicans in mice and humans. However, mice with defective IL-17 immunity display broader susceptibility, as they are also prone to infections with diverse infectious agents at various sites. Humans with genetic defects affecting their IL-17 immunity usually suffer from chronic mucocutaneous candidiasis (CMC): recurrent or persistent infections of the skin, nails, and mucosae with C. albicans, with or without other clinical signs. Most patients with autosomal dominant (AD) hyper-IgE syndrome (HIES) due to STAT3 deficiency or AD STAT1 gain-of-function display impaired IL-17-producing T-cell development, and CMC is one of their principal clinical manifestations. Similarly, patients with autosomal recessive (AR) autoimmune polyendocrine syndrome type 1 (APS-1) caused by AIRE deficiency have high levels of neutralizing autoantibodies against IL-17A, IL-17F and/or IL-22 and present CMC as their only infectious disease. Finally, CMC is the main clinical phenotype observed in patients with inborn errors specifically affecting IL-17 immunity. Indeed, patients with AD IL-17F deficiency or AR IL-17RA or ACT1 deficiency display CMC and, to a lesser extent, superficial staphylococcal diseases. Candida infection was recently reported in psoriasis patients treated with anti-IL-17A antibodies. Careful monitoring for CMC is thus important during anti-IL-17 treatment. PMID:25398490

  14. Lagrange-Poincaré reduction for optimal control of underactuated mechanical systems

    E-print Network

    Leonardo Colombo

    2015-01-20

    We deal with regular Lagrangian constrained systems which are invariant under the action of a symmetry group. Fixing a connection on the higher-order principal bundle where the Lagrangian and the (independent) constraints are defined, the higher-order Lagrange-Poincar\\'e equations of classical mechanical systems with higher-order constraints are obtained from classical Lagrangian reduction. Higher-order Lagrange-Poincar\\'e operator is introduced to characterize higher-order Lagrange-Poincar\\'e equations. Interesting applications are derived as, for instance, the optimal control of an underactuated Elroy's Beanie and a snakeboard seens as an optimization problem with higher-order constraints.

  15. Parking Fees Thefollowingfeesapplyfortherampgarage

    E-print Network

    Portman, Douglas

    Parking Fees Thefollowingfeesapplyfortherampgarage and for all visitor lots: 0-30 Minutes Free 31 or misplaced parking tickets. How to pay for parking Takeyour entry ticket withyouwhen entering the hospital--this will give you the most optionsforpayment. You can pay for parking with cash, check, credit card

  16. University Parking & Transportation Services

    E-print Network

    Portman, Douglas

    Citation Appeals Guidelines University Parking & Transportation Services www.rochester.edu/parking For more information contact University Parking and Transportation Services Medical Center 273.4524 River/regulations · Other cars illegally/improperly parked · Late to appointment/class · Inability to pay the citation

  17. University Parking & Transportation Services

    E-print Network

    Portman, Douglas

    3-D Parking University Parking & Transportation Services Box 621 Rochester, NY 14692 (585) 275.4524 www.rochester.edu/parking If you misplace or lose your lock-box, there will be a replacement fee must drive an unregistered vehicle, call the Parking Office to inform them of the vehicle information

  18. Lane Avenue Parking Garage

    E-print Network

    Jones, Michelle

    Lane Avenue Parking Garage Neil Avenue Footbridge Sisson Hall Parking Lot Getting to campus From Avenue and go east. Continue with directions to Day One or Day Two parking. From the west: Take any major. Continue with directions to Day One or Day Two parking. From the east: Take any major highway to I-70 West

  19. Parking and Traffic Regulations

    E-print Network

    Tufts University

    Parking and Traffic Regulations July 2001 Edition Department of Public Safety Parking and Traffic Services 419 Boston Avenue Medford, MA 02155 (617) 627-3692 parking @tufts.edu Visit http and to operate a motor vehicle on the streets, drive- ways and parking lots of the campus. 4. DEFINITIONS A

  20. PARKING OFFICER Position Information

    E-print Network

    Ponce, V. Miguel

    PARKING OFFICER Position Information Full-time, permanent (probationary) position. Salary Range $2,456 - $3,682 mo. Commensurate with knowledge, skills, and experience. Responsibilities Issue parking citations in parking lots, structures and the core of campus for vehicles in violation of University parking

  1. Parking Services: 2010 2011

    E-print Network

    Khan, Javed I.

    Regional Map: Parking Services: 2010 ­ 2011 Kent State University Traffic on campus is heavy. There is always competi- tion for parking in the areas closest to campus. If you need to bring your vehicle on campus... Non-visitors must purchase and display a valid parking permit obtained through Parking Services

  2. visitor parking rice village

    E-print Network

    Richards-Kortum, Rebecca

    Central Campus Garage visitor parking tennis courts rice village apartments at 2410 shakespeare st visitor parking faculty, staff, student, contract parking Greenbriar Lot West Lot 4 W faculty, staff, student West Lot 2 faculty, staff, student West Lot 3 resident students faculty, staff, student parking SC

  3. Glacier National Park

    NSDL National Science Digital Library

    This is the homepage of Glacier National Park. Users can access materials on the park's ecology and environment (plants and animals, biodiversity and air quality, geology, and fires), the culture and history of the park, park activities, and publications on naturalist activities. There are also video clips of park wildlife and scenery, a photo gallery, and live webcams. Links are provided to additional information, such as research activities on bear DNA and global climate change.

  4. Skeletal Pathology in Pan troglodytes schweinfurthii in Kibale National Park, Uganda

    E-print Network

    Pontzer, Herman

    Skeletal Pathology in Pan troglodytes schweinfurthii in Kibale National Park, Uganda Melinda L History, Chicago, IL KEY WORDS skeletal pathology; body size; chimpanzees; poaching; primate health size, morbidity, and mortality are rare for wild chimpanzees. Here, we present skeletal pathology

  5. Comparison of CECOR Algorithm to Lagrange Multiplier Method to Estimate Reactor Power Distributions

    SciTech Connect

    Webb, Raymond J.; Brittingham, James C. [Arizona Public Service Company (United States)

    2000-11-15

    The Lagrange Multiplier method was tested to determine its capability for replacing the current Combustion Engineering Core (CECOR) method for estimating the Palo Verde Nuclear Generating Station reactor power distributions.The Lagrange Multiplier method involves minimizing the sum of the squared residuals of 241 coupling equations subject to 61 constraint equations. The CECOR method solves 180 (241 - 61) coupling equations subject to the 61 constraint equations. The Lagrange method is more complex because it includes the 61 additional coupling equations.The 'consistency test' was used to test the accuracy of both methods for computing the power in uninstrumented assemblies, i.e., one-by-one, each of the detectors is considered not available, and the remaining detectors are used to compute the powers in the uninstrumented assemblies.There is potential for expanding the Lagrange method to a three-dimensional approach that could produce even better results, and that is a consideration.

  6. Lagrange Inversion: when and how D. Merlini, R. Sprugnoli, M. C. Verri

    E-print Network

    Merlini, Donatella

    Lagrange Inversion: when and how D. Merlini, R. Sprugnoli, M. C. Verri Dipartimento di Sistemi e Informatica viale Morgagni 65, 50134, Firenze, Italia [merlini,sprugnoli,verri]@dsi.unifi.it Abstract The aim

  7. Centrifuge Rotor Models: A Comparison of the Euler-Lagrange and the Bond Graph Modeling Approach

    NASA Technical Reports Server (NTRS)

    Granda, Jose J.; Ramakrishnan, Jayant; Nguyen, Louis H.

    2006-01-01

    A viewgraph presentation on centrifuge rotor models with a comparison using Euler-Lagrange and bond graph methods is shown. The topics include: 1) Objectives; 2) MOdeling Approach Comparisons; 3) Model Structures; and 4) Application.

  8. Teleparallel Lagrange Geometry and a Unified Field Theory

    E-print Network

    M. I. Wanas; Nabil L. Youssef; A. M. Sid-Ahmed

    2010-02-13

    In this paper, we construct a field theory unifying gravity and electromagnetism in the context of Extended Absolute Parallelism (EAP-) geometry. This geometry combines, within its structure, the geometric richness of the tangent bundle and the mathematical simplicity of Absolute Parallelism (AP-) geometry. The constructed field theory is a generalization of the Generalized Field Theory (GFT) formulated by Mikhail and Wanas. The theory obtained is purely geometric. The horizontal (resp. vertical) field equations are derived by applying the Euler-Lagrange equations to an appropriate horizontal (resp. vertical) scalar Lagrangian. The symmetric part of the resulting horizontal (resp. vertical) field equations gives rise to a generalized form of Einstein's field equations in which the horizontal (resp. vertical) energy-momentum tensor is purely geometric. The skew-symmetric part of the resulting horizontal (resp. vertical) field equations gives rise to a generalized form of Maxwell equations in which the electromagnetic field is purely geometric. Some interesting special cases, which reveal the role of the nonlinear connection in the obtained field equations, are examined. Finally, the condition under which our constructed field equations reduce to the GFT is explicitly established.

  9. National Park Service: Tour of Park Geology

    NSDL National Science Digital Library

    The tour of Park geologic resources includes pages specific to individual National Parks, Monuments, Recreation Areas, Preserves, Seacoasts, Reserves, and Recreation Areas. These pages are indexed by park name, state, or by one of the following topics: basin and range, caves, Colorado Plateau, fossils, glaciers, hot springs, human use, mountain building, oldest rocks, plate tectonics, river systems, sand dunes, shoreline geology, or volcanoes. Organization of each of the pages typically follows a NPS template with categories for park geology, maps, photographs, geologic research, related links, visitor information, multimedia, and "teacher features" (educational resources and links for teaching geology with National Park examples.) Common subjects that are addressed at various park sites include: minerals, rocks, fossils, cave and karst systems, coastlines, glaciers, volcanoes, faults, landforms, landslides, structures, fluvial systems, sediments, soils, stratigraphic relations, processes that form or act on geologic features and their chemical compositions, and the history of the planet and its life forms.

  10. IL1-Antagonisten

    Microsoft Academic Search

    I. Kötter; G. Horneff

    2010-01-01

    Zusammenfassung  Interleukin- (IL-)1 spielt eine wichtige Rolle nicht nur in der Entzündungsvermittlung, sondern auch in der Knochen- und Knorpeldestruktion.\\u000a Zusammen mit TNF-? ist es eines der in der Pathogenese der rheumatoiden Arthritis (RA) und juvenilen idiopathischen Arthritis\\u000a (JIA) wesentlichen Zytokine. Der IL-1-Rezeptorantagonist Anakinra ist der erste zur Therapie der RA zugelassen IL-1-Antagonist,\\u000a war aber weniger effektiv als TNF-Antagonisten. Dies hat dazu

  11. Acadia National Park: Teachers

    NSDL National Science Digital Library

    This National Park Service website contains information on: saving the habitats of peregrine falcons; the water cycle; becoming a junior ranger; and ranger-led school programs, which contain student field activities about the history, biology and geology of the park. Teacher resources include information on a library for educators at the visitor center of the park and teacher guides for preparing to visit the park. The kids' section explains what rangers do, gives tips on leaving no trace in the park, provides a history of Mount Desert Island, and contains an activity to match some park animals to their habitats.

  12. Running Title: Gaze Direction Perception Authors: Hooker and Park IN PRESS. COGNITIVE NEURPSYCHIATRY

    E-print Network

    Park, Sohee

    Running Title: Gaze Direction Perception Authors: Hooker and Park - 1 - IN PRESS. COGNITIVE Hooker, Ph.D. and Sohee Park, Ph.D. Department of Psychology, Northwestern University, Evanston, IL 60208 Address reprints requests to either Christine Hooker, Helen Wills Neuroscience Institute, 132 Barker Hall

  13. A new Remesh-Lagrange technique for advecting temperature that minimizes numerical diffusion

    NASA Astrophysics Data System (ADS)

    Hasenclever, J.; Phipps Morgan, J.; Shi, C.

    2007-12-01

    The proper treatment of heat-advection is a generally underappreciated problem within CFD, yet particularly critical for calculating physically sound erosion in plume-lithosphere interactions and temperature sensitive melting processes. Typically, Eulerian (fixed-mesh) codes have been preferred to solve for fluid flow and they are almost essential for finite-difference-based algorithms. Unfortunately, the Eulerian approach introduces numerical artifacts into the solution of the advection-diffusion heat transport problem that can only be suppressed by adding 'too-diffusive' artificial diffusion to the equations, as for example in the Smolarkiewicz formulation for heat advection. We have developed a 'Remesh-Lagrange' method using a partly deforming finite element mesh and find it to be significantly more accurate than our previous methods. In several test scenarios we show the large improvement in accuracy that can be obtained by using a Lagrangian approach for 10-30 time steps (depending upon the distortion of the finite elements in the deformed Lagrangian mesh) and then regridding to the initial mesh. When an element becomes too distorted the nodes connected to it become fixed and we switch from Lagrange to a Semi-Lagrange formulation for these nodes. Instead of the standard 'linear backward' Semi-Lagrange we are also experimenting with a more accurate interpolation scheme for an unstructured mesh that additionally includes the nodal derivatives of the temperature field when calculating the value at the Semi-Lagrange traceback point. The same bicubic interpolation method for an unstructured grid is used to remesh the 'too-distorted' Lagrange grid back to the initial undistorted mesh. We compare the Remesh-Lagrange technique against the following Eulerian methods in a series of 2-D numerical experiments advecting stripes and Gaussian peaks in steady circulating flow: linear back-interpolation Semi-Lagrange method; bicubic back-interpolation Semi-Lagrange method; SUPG; and the Smolarkiewicz (flux- limiting diffusion) method, which is arguably the 'best-in-practice' of the Eulerian finite-difference methods. We also compare these methods for a test-case of diapiric upwelling that is forced by a pure chemical (non-diffusive) buoyancy associated with tracer particles that are advected by the plume upwelling. In this case, we find that the Eulerian methods typically underpredict the temperature of the plume head by about 20C, while overheating a ~50km region outside the plume-stem by about 10C in comparison to the Remesh-Lagrange technique.

  14. Visitor and Contractor Parking Policy

    E-print Network

    Facilities Visitor and Contractor Parking Policy #12;#12;Visitor and Contractor Parking Policy 1 Facilities Visitor and Contractor Parking Policy Contents Page 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6 2.6 Sports Centre Visitor Car Parking

  15. Notice From Security & Parking Services to those requiring Shift Parking

    E-print Network

    Hitchcock, Adam P.

    Notice From Security & Parking Services to those requiring Shift Parking Shift parking is issued beyond the shuttle bus hours of operation. Shift parking allows a Lot M, N, O or P transponder holder to park on central campus after 2:30 pm. Shift parking is provided at no extra charge to employees who

  16. Selected Parking Types Resident Parking,Permit Required

    E-print Network

    Chen, Tsuhan

    Selected Parking Types Resident Parking,Permit Required Commuter Parking,Permit Required Metered Parking Lot Night/Weekend Restricted Permit Area 10 Minute Parking,No Permit Required Parkmobile Pay-by-Cell Parking Lot North Campus B Lot Sage Hall Campus-to-Campus Stops A B C ©2013This map replaces previous

  17. Yellowstone Park

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Thirteen years after devastating forest fires burned over 1.6 million acres in Yellowstone National Park, the scars are still evident. In this simulated natural color ASTER image, burned areas appear gray, in contrast to the dark green of unburned forests. The image covers an area of 60 x 63 km. This image was acquired on July 2, 2001 by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet.

    ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products.

    The broad spectral coverage and high spectral resolution of ASTER will provide scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance.

    Dr. Anne Kahle at NASA's Jet Propulsion Laboratory, Pasadena, California, is the U.S. Science team leader; Bjorn Eng of JPL is the project manager. The Terra mission is part of NASA's Earth Science Enterprise, a long- term research effort to understand and protect our home planet. Through the study of Earth, NASA will help to provide sound science to policy and economic decision-makers so as to better life here, while developing the technologies needed to explore the universe and search for life beyond our home planet.

    Size: 60 x 63 km (37.2 x 39.1 miles) Location: 44.7 deg. North lat., 110.7 deg. West long. Orientation: North at top Image Data: ASTER bands 1,2, and 3. Original Data Resolution: 15 m Date Acquired: July 2, 2001

  18. Alaska Park Science National Park Service

    E-print Network

    Birkedal, Team Leader for Cultural Resources; Alex Carter, Team Manager for Biological Resources Team; Joy Geiselman, Deputy Chief, Biological Science Office USGS Alaska Science Center; Sue Huse, Natural Resources;Alaska Park Science Connections to Natural and Cultural Resource Studies in Alaska's National Parks

  19. PEABODY PARK TAYLOR GARDEN

    E-print Network

    Saidak, Filip

    FOUST PARK PEABODY PARK TAYLOR GARDEN KAPLAN COMMONS Start- Peabody Park Trail Start Golf Course TOWER VILLAGE MOORE-STRONG SOUTH SPENCER SPRING GARDEN APARTMENTS PRINT SHOP CHEMICAL SAFETY CARMICHEAL BASEBALL SEATING CAMPUS MINISTRIES 1605 SPRING GARDEN 117 MCIVER VISITOR CENTER SOFTBALL FIELD CAMPUS

  20. NATIONAL PARK BOUNDARIES

    EPA Science Inventory

    The National Park Service has produced a data base of boundaries for its National Parks. A copy of this data was downloaded from the National Parks Service ftp site by Region 10. These digital boundaries represent the best guess and data that could be collected in a short time....

  1. Name That Park

    NSDL National Science Digital Library

    National Park Service

    2013-05-15

    In this online interactive, learners are introduced to the basic function of Geographic Information System (GIS) maps in relation to national parks. Recognizable park boundaries are presented and learners are given the option to add layers such as lakes, rivers and visitor centers, until the learner is able to identify the park map from a list of choices.

  2. Parking Procedures GUIDELINES

    E-print Network

    Grant, Gregory

    Parking Procedures GUIDELINES: Issued: Date Issued ­ January 9, 2014 Revised: Date Revised ­ June 10, 2014 PURPOSE: To establish guidelines for the regulation of parking on the Washington University in St. Louis School of Medicine campus to ensure fair and equitable parking arrangements while

  3. Dynamic orbit propagation in a gravitational field of an inhomogeneous attractive body using the Lagrange coefficients

    NASA Astrophysics Data System (ADS)

    Sharifi, M. A.; Seif, M. R.

    2011-09-01

    The analytical methods have nearly been replaced by the numerical methods due to their higher accuracy and accessibility of computation facilities. The semi-analytical Lagrange method of orbit propagation using f and g series is a competitive alternative to the numerical integration technique if the Lagrange coefficients are derived in a full gravitational field. In this paper, a generalization of the Lagrange method of orbit propagation is introduced. In other words, we introduce a complete form of the Lagrange coefficients in all force fields developed in the spherical harmonics for example full gravitational field of the Earth. The method is numerically compared with the numerical integration technique. In order to show the numerical performance of the method, it has been implemented for orbit propagation of a GPS-like MEO and CHAMP-like LEO satellites. Discrepancy at centimeter level for CHAMP-like and sub-millimeter accuracy for GPS-like satellites shows relatively high performance of the developed algorithm. Compared to integration method, the proposed Lagrange method is nearly faster by a factor two for small Nmax and four for large Nmax.

  4. Great Basin National Park

    NSDL National Science Digital Library

    This National Park Service site describes the biology of Great Basin's plants and animals; geology and ecology of the Lehman Caves; air quality of the park; and past human activities in the Great Basin such as farming, ranching, and gold mining. There is a list of historical, geological, and archeological dates important to the park and an instructor guide containing activities such as creating a nature notebook and adopting a tree. There is also information on: planning a visit to the park and the Lehman Caves, park projects such as weeding out non-native plants and the reintroduction of Bonneville Cutthroat Trout, and a self-guided geology field trip.

  5. Theme Park Insider

    NSDL National Science Digital Library

    Niles, Robert.

    As summer enters full swing, more and more people will travel to America's numerous amusement parks and traveling carnivals. Quite a few of these people would do well to take a look at the Theme Park Insider website for reviews of various parks and the best (and worst) attractions at each particular place of amusement before they venture onto the open road. Edited by Robert Niles, the site contains reviews of new amusement park rides, an "Accident Watch" (which documents the latest accidents at each park), and reviews of theme park hotels as well. The site also has a number of discussion boards for visitors to chime in with their own take on a number of topics, such as which rides have the longest rides and general amusement park lore.

  6. Chicago Park District

    NSDL National Science Digital Library

    2013-01-01

    The Chicago Park District is one of the largest municipal park systems in the United States, containing over 8,100 acres of green space. All told, the District has 580 parks, including two city conservatories, a number of historic lagoons, and the iconic Clarence Buckingham Memorial Fountain. This website allows visitors the opportunity to learn about the District's mission, history, and long-range planning for existing parks and potential new sites. On the homepage, visitors can use the Find a Park feature to learn about these diverse spaces. Additionally, they can use the I Want To area to learn about park permits, volunteering, and reporting problems within the park system. The Events area is quite a find, as visitors can learn about some of the hundreds of events sponsored each year by the District. Finally, visitors can also use the Doing Business area to learn about the various entrepreneurial activities which are possible via the District.

  7. MILLERSVILLE UNIVERSITY PARKING REGULATIONS AND PROCEDURES

    E-print Network

    Hardy, Christopher R.

    MILLERSVILLE UNIVERSITY PARKING REGULATIONS AND PROCEDURES 2012-2013 CONTENTS 1. General Regulations ­ Driving and Parking 10. Handicapped Parking 11. Motorcycle Regulations 12. Reserved Spaces 13. Specific Parking Regulations 14. Parking Violations Penalties, Fines and Fees 15. Appeals of Parking

  8. The algebraic index theorem and deformation quantization of Lagrange-Finsler and Einstein spaces

    NASA Astrophysics Data System (ADS)

    Vacaru, Sergiu I.

    2013-07-01

    Various types of Lagrange and Finsler geometries, Einstein gravity, and modifications, can be modelled by nonholonomic distributions on tangent bundles/manifolds when the fundamental geometric objects are adapted to nonlinear connection structures. We can convert such geometries and physical theories into almost Kähler/Poisson structures on (co)tangent bundles. This allows us to apply deformation quantization formalism to almost symplectic connections induced by Lagrange-Finsler and/or Einstein fundamental geometric objects. There are constructed respective nonholonomic versions of the trace density maps for the zeroth Hochschild homology of deformation quantization of distinguished algebras (in this work, adapted to nonlinear connection structure). Our main result consists in an algebraic index theorem for Lagrange-Finsler and Einstein spaces. Finally, we show how the Einstein field equations for gravity theories and geometric mechanics models can be imbedded into the formalism of deformation quantization and index theorem.

  9. IL28, IL29 and their class II cytokine receptor IL28R

    Microsoft Academic Search

    Paul Sheppard; Wayne Kindsvogel; Wenfeng Xu; Katherine Henderson; Stacy Schlutsmeyer; Theodore E. Whitmore; Rolf Kuestner; Ursula Garrigues; Carl Birks; Jenny Roraback; Craig Ostrander; Dennis Dong; Jinu Shin; Scott Presnell; Brian Fox; Betty Haldeman; Emily Cooper; David Taft; Teresa Gilbert; Francis J. Grant; Monica Tackett; William Krivan; Gary McKnight; Chris Clegg; Don Foster; Kevin M. Klucher

    2002-01-01

    Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by

  10. Technique to eliminate computational instability in multibody simulations employing the Lagrange multiplier

    NASA Technical Reports Server (NTRS)

    Watts, G.

    1992-01-01

    A programming technique to eliminate computational instability in multibody simulations that use the Lagrange multiplier is presented. The computational instability occurs when the attached bodies drift apart and violate the constraints. The programming technique uses the constraint equation, instead of integration, to determine the coordinates that are not independent. Although the equations of motion are unchanged, a complete derivation of the incorporation of the Lagrange multiplier into the equation of motion for two bodies is presented. A listing of a digital computer program which uses the programming technique to eliminate computational instability is also presented. The computer program simulates a solid rocket booster and parachute connected by a frictionless swivel.

  11. Position-dependent mass Lagrangians: nonlocal transformations, Euler-Lagrange invariance and exact solvability

    E-print Network

    Omar Mustafa

    2015-05-08

    A general non-local point transformation for position-dependent mass Lagrangians and their mapping into a "constant unit-mass" Lagrangians in the generalized coordinates is introduced. The conditions on the invariance of the related Euler-Lagrange equations are reported. The harmonic oscillator linearization of the PDM Euler-Lagrange equations is discussed through some illustrative examples including harmonic oscillators, shifted harmonic oscillators, a quadratic nonlinear oscillator, and a Morse-type oscillator. The Mathews-Lakshmanan nonlinear oscillators are reproduced and some "shifted" Mathews-Lakshmanan nonlinear oscillators are reported. The mapping of an isotonic nonlinear oscillator into a PDM deformed isotonic oscillator is also discussed.

  12. Position-dependent mass Lagrangians: nonlocal transformations, Euler–Lagrange invariance and exact solvability

    NASA Astrophysics Data System (ADS)

    Mustafa, Omar

    2015-06-01

    A general nonlocal point transformation for position-dependent mass (PDM) Lagrangians and their mapping into a ‘constant unit-mass’ Lagrangians in the generalized coordinates is introduced. The conditions on the invariance of the related Euler–Lagrange equations are reported. The harmonic oscillator linearization of the PDM Euler–Lagrange equations is discussed through some illustrative examples including harmonic oscillators, shifted harmonic oscillators, a quadratic nonlinear oscillator, and a Morse-type oscillator. The Mathews–Lakshmanan nonlinear oscillators are reproduced and some ‘shifted’ Mathews–Lakshmanan nonlinear oscillators are reported. The mapping of an isotonic nonlinear oscillator into a PDM deformed isotonic oscillator is also discussed.

  13. PARKING LOT 164 PARKING LOT 114

    E-print Network

    Wilmers, Chris

    N IN E &TEN APTS BLDG 1 GANDHIHOUSE AMNESTY HOUSE Disabled parking space Disabled access path shuttle stop Santa Cruz Metro bus stop Stairs Elevator Restrooms NINE &TEN APTSBLDG3 NINE &TEN APTS BLDG 2

  14. PARKING LOT 164 PARKING LOT 114

    E-print Network

    Wilmers, Chris

    LIVINGCENTERINTERNATIONAL BLDG 5 N IN E &TEN APTS BLDG 1 GANDHIHOUSE AMNESTY HOUSE Disabled parking space Disabled access Campus shuttle stop Santa Cruz Metro bus stop Stairs Elevator Restrooms NINE &TEN APTSBLDG3 NINE &TEN

  15. Urban Parks: Constraints on Park Visitation

    E-print Network

    Scott, David

    2006-12-19

    Research shows that women, older people, members of some ethnic groups, and people with low educational and income levels are less likely than others to participate in leisure activities or visit parks. This publication explores the constraints...

  16. VISITOR PARKING Pay station parking meters are available around

    E-print Network

    VISITOR PARKING Pay station parking meters are available around campus for visitors and other temporary parking needs. Daily scratch-off permits are available in advance from Parking Services. LOT METER PAY STATION RATES (SUMMER RATES MAY BE DISCOUNTED) HOW DO I GET A PERMIT? When parking on campus

  17. Parking and Transport Policy Page 1 Parking and Transport Policy

    E-print Network

    Parking and Transport Policy Page 1 Parking and Transport Policy Category: Facilities, Campus Life 1. PURPOSE To standardise and manage parking and transport on the Curtin Bentley campus including Technology Park. 2. POLICY STATEMENT 2.1 Curtin University will provide an appropriate number of parking bays

  18. Resolution of the Gross-Pitaevskii equation with the imaginary-time method on a Lagrange mesh.

    PubMed

    Baye, D; Sparenberg, J-M

    2010-11-01

    The Lagrange-mesh method is an approximate variational calculation which has the simplicity of a mesh calculation. Combined with the imaginary-time method, it is applied to the iterative resolution of the Gross-Pitaevskii equation. Two variants of a fourth-order factorization of the exponential of the Hamiltonian and two types of mesh (Lagrange-Hermite and Lagrange-sinc) are employed and compared. The accuracy is checked with the help of these comparisons and of the virial theorem. The Lagrange-Hermite mesh provides very accurate results with short computing times for values of the dimensionless parameter of the nonlinear term up to 10?. For higher values up to 10?, the Lagrange-sinc mesh is more efficient. Examples are given for anisotropic and nonseparable trapping potentials. PMID:21230613

  19. Parks, Recreation and Public Health.

    ERIC Educational Resources Information Center

    Ho, Ching-Hua; Payne, Laura; Orsega-Smith, Elizabeth; Godbey, Geoffrey

    2003-01-01

    Reviews what current research says about the holistic health benefits of park and recreation services, focusing on: health benefits according to park users; physical activities in parks; stress reduction benefits of park use; social support, self-determination, and stress reduction; observing nature in parks and associated benefits; and the…

  20. Dead Mans Run parking for

    E-print Network

    Farritor, Shane

    Dead ManŐs Run 44THSTREET parking for state vehicles Dead ManŐs Run East Campus Recr eation Fields of the University of Nebraska parking map is intended for web distribution only. Further information, including parking regulations, permit information, etc., is available at Parking and Transit Services website, http://parking

  1. Mapping the National Parks

    NSDL National Science Digital Library

    This website contains a collection of maps documenting the history, cultural aspects and geological formations of areas that eventually became National Parks. The areas highlighted are Acadia National Park, Yellowstone National Park, the Grand Canyon, and the Great Smoky Mountains. The collection consists of approximately 200 maps dating from the 17th century to the present, reflecting early mapping of these areas. This database is searchable by keyword, geographic location, subject, map creator, or title.

  2. 1. PARKING LOT BEFORE SOUTH ENTRANCE STATION, FACING N. PARK ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. PARKING LOT BEFORE SOUTH ENTRANCE STATION, FACING N. PARK ENTRANCE SIGN IS IN TREES IN CENTER. - South Entrance Road, Between South park boundary & Village Loop Road, Grand Canyon, Coconino County, AZ

  3. SOUND SOURCE TRACKING AND FORMATION USING NORMALIZED CUTS Mathieu Lagrange, George Tzanetakis

    E-print Network

    Tzanetakis, George

    SOUND SOURCE TRACKING AND FORMATION USING NORMALIZED CUTS Mathieu Lagrange, George Tzanetakis such that each package most likely has arisen from a single sound source. We formulate sound source tracking scene analysis, sinusoidal mod- eling, sound source tracking, normalized cut 1. INTRODUCTION

  4. Using Euler-Lagrange Variational Principle to Obtain Flow Relations for Generalized Newtonian Fluids

    E-print Network

    Taha Sochi

    2013-01-13

    Euler-Lagrange variational principle is used to obtain analytical and numerical flow relations in cylindrical tubes. The method is based on minimizing the total stress in the flow duct using the fluid constitutive relation between stress and rate of strain. Newtonian and non-Newtonian fluid models; which include power law, Bingham, Herschel-Bulkley, Carreau and Cross; are used for demonstration.

  5. Field theory and weak Euler-Lagrange equation for classical particle-field systems

    NASA Astrophysics Data System (ADS)

    Qin, Hong; Burby, Joshua W.; Davidson, Ronald C.

    2014-10-01

    It is commonly believed as a fundamental principle that energy-momentum conservation of a physical system is the result of space-time symmetry. However, for classical particle-field systems, e.g., charged particles interacting through self-consistent electromagnetic or electrostatic fields, such a connection has only been cautiously suggested. It has not been formally established. The difficulty is due to the fact that the dynamics of particles and the electromagnetic fields reside on different manifolds. We show how to overcome this difficulty and establish the connection by generalizing the Euler-Lagrange equation, the central component of a field theory, to a so-called weak form. The weak Euler-Lagrange equation induces a new type of flux, called the weak Euler-Lagrange current, which enters conservation laws. Using field theory together with the weak Euler-Lagrange equation developed here, energy-momentum conservation laws that are difficult to find otherwise can be systematically derived from the underlying space-time symmetry.

  6. A constructive formula for function of matrix. Alternative to the Lagrange-Sylvester formula

    NASA Astrophysics Data System (ADS)

    Robuk, V. N.

    2004-11-01

    Instead of the elegant function (Lagrange-Sylvester formula) depending on badly-defined arguments (eigenvalues) we suggest a cumbersome function (hypergeometrical series) depending on well-defined arguments (matrix invariants). The function of matrix M^ implies the sum of any formal finite or infinite power series of M^ with arbitrary coefficients.

  7. Generalized Hermite formula for the two-sided Lagrange-Sylvester interpolation

    NASA Astrophysics Data System (ADS)

    Hu, Yong-Jian; Yang, Zheng-Hong; Chen, Gong-Ning

    2005-01-01

    The classical Hermite formula of the scalar polynomial interpolation is generalized to the setting of two-sided Lagrange-Sylvester interpolation for matrix polynomials. The formula then is applied to a description of the set of all matrix polynomial solutions to that two-sided interpolation.

  8. Searching for life with the Terrestrial Planet Finder: Lagrange point options for a formation flying interferometer

    E-print Network

    Barcelona, Universitat de

    Searching for life with the Terrestrial Planet Finder: Lagrange point options for a formation. The Terrestrial Planet Finder (TPF) is one of the key missions in NASA's Astronomical Search for Origins search for origins; Searching for life; Terrestrial Planet Finder; TPF; Halo orbit; L2; Heliocentric

  9. CONVERGENT DISCRETIZATION OF HEAT AND WAVE MAP FLOWS TO SPHERES USING APPROXIMATE DISCRETE LAGRANGE MULTIPLIERS

    E-print Network

    Bartels, Soeren

    CONVERGENT DISCRETIZATION OF HEAT AND WAVE MAP FLOWS TO SPHERES USING APPROXIMATE DISCRETE LAGRANGE to approximate the harmonic map heat flow, and the wave map into spheres. The proposed finite-element based.3) u(0, ·) = u0 in ,(1.4) and B) the wave map flow into the sphere Sm-1, utt - u = |u|2 - | ut |2 u

  10. Necessary conditions for weighted mean convergence of Lagrange interpolation for exponential weights

    NASA Astrophysics Data System (ADS)

    Damelin, S. B.; Jung, H. S.; Kwon, K. H.

    2001-07-01

    Given a continuous real-valued function f which vanishes outside a fixed finite interval, we establish necessary conditions for weighted mean convergence of Lagrange interpolation for a general class of even weights w which are of exponential decay on the real line or at the endpoints of (-1,1).

  11. Pointwise convergence of derivatives of Lagrange interpolation polynomials for exponential weights

    NASA Astrophysics Data System (ADS)

    Damelin, S. B.; Jung, H. S.

    2005-01-01

    For a general class of exponential weights on the line and on (-1,1), we study pointwise convergence of the derivatives of Lagrange interpolation. Our weights include even weights of smooth polynomial decay near +/-[infinity] (Freud weights), even weights of faster than smooth polynomial decay near +/-[infinity] (Erdos weights) and even weights which vanish strongly near +/-1, for example Pollaczek type weights.

  12. Field theory and weak Euler-Lagrange equation for classical particle-field systems.

    PubMed

    Qin, Hong; Burby, Joshua W; Davidson, Ronald C

    2014-10-01

    It is commonly believed as a fundamental principle that energy-momentum conservation of a physical system is the result of space-time symmetry. However, for classical particle-field systems, e.g., charged particles interacting through self-consistent electromagnetic or electrostatic fields, such a connection has only been cautiously suggested. It has not been formally established. The difficulty is due to the fact that the dynamics of particles and the electromagnetic fields reside on different manifolds. We show how to overcome this difficulty and establish the connection by generalizing the Euler-Lagrange equation, the central component of a field theory, to a so-called weak form. The weak Euler-Lagrange equation induces a new type of flux, called the weak Euler-Lagrange current, which enters conservation laws. Using field theory together with the weak Euler-Lagrange equation developed here, energy-momentum conservation laws that are difficult to find otherwise can be systematically derived from the underlying space-time symmetry. PMID:25375609

  13. Detection of Differential Item Functioning Using Lagrange Multiplier Tests. Research Report 96-02.

    ERIC Educational Resources Information Center

    Glas, Cees A. W.

    In this paper it is shown that differential item functioning can be evaluated using the Lagrange multiplier test or C. R. Rao's efficient score test. The test is presented in the framework of a number of item response theory (IRT) models such as the Rasch model, the one-parameter logistic model, the two-parameter logistic model, the generalized…

  14. Model Modification in Covariance Structure Modeling: A Comparison among Likelihood Ratio, Lagrange Multiplier, and Wald Tests.

    ERIC Educational Resources Information Center

    Chou, Chih-Ping; Bentler, P. M.

    1990-01-01

    The empirical performance under null/alternative hypotheses of the likelihood ratio difference test (LRDT); Lagrange Multiplier test (evaluating the impact of model modification with a specific model); and Wald test (using a general model) were compared. The new tests for covariance structure analysis performed as well as did the LRDT. (RLC)

  15. Application of "AIC" to Wald and Lagrange Multiplier Tests in Covariance Structure Analysis.

    ERIC Educational Resources Information Center

    Chou, Chih-Ping; Bentler, P. M.

    1996-01-01

    Some efficient procedures are proposed for using the Akaike Information Criterion (H. Akaike, 1987), an alternative to the conventional chi-square goodness of fit test, in covariance structure analysis based on backward search through the Wald test to impose constraints and forward search through the Lagrange test to release constraints. (SLD)

  16. Some aspects of statistical inference on the lagrange (generalized) poisson distribution

    Microsoft Academic Search

    M. M. Shoukri; I. U. H. Mian

    1991-01-01

    A generalization of the Poisson distribution was defined by Consul and Jain (Ann. Math. Statist., 41, (1970)) and was obtained as a particular family of Lagrange distributions by Consul and Shenton (SIAM. J. Appl. Math., 23, (1972)). The distribution is subsequently named the generalized Poisson distribution (GPD). This GPD reduces to the Poisson distribution for ? = 0. When the

  17. F72-6 PARKING (PARKING COMMITTEE ABOLISHED AND REPLACED BY PARKING ADVISORY BOARD)

    E-print Network

    Gleixner, Stacy

    F72-6 PARKING (PARKING COMMITTEE ABOLISHED AND REPLACED BY PARKING ADVISORY BOARD) Legislative Committee. ACTION BY UNIVERSITY PRESIDENT: "Approved." Signed: John H. Bunzel, January 22, 1973. PARKING Parking Committee be abolished. 2. The Academic Council recommend that the Director of Business Affairs

  18. Downtown-parking policy analysis

    SciTech Connect

    Kuner, R.

    1983-10-01

    This article outlines a framework for recognizing city parking policy alternatives and evaluating their effectiveness or desirability for solving parking problems. The techniques are useful for making parking policy decisions. 6 references, 1 table.

  19. Yellowstone National Park Interactive Map

    NSDL National Science Digital Library

    NPS Source: CENSUS

    This Yellowstone National Park Map is a handy way to quickly find locations and buildings located in the park. It is currently the most detailed map of Yellowstone national park that can be viewed online. The pull down menu has Yellowstone features such as geyser basins, campgrounds, trails, mountains, and historical points and park structures. Popular geysers, and park locations such as Norris geyser basin, Yellowstone visitor centers, park housing, lodging, and park dining can be easily found. All Yellowstone National Park named structures are indexed so you can easily find the sites that you want to locate.

  20. Active England `Park Life'

    E-print Network

    Active England `Park Life' ­ Greenwood Community Forest Liz O'Brien and Jake Morris Social Life: Design and implementation 6 3. Results: on site surveying and project monitoring 9 3 funded project, `Park Life', within Greenwood Community Forest (hereafter `Greenwood'), and the results

  1. Visitor's Car Parking Information

    E-print Network

    Visitor's Car Parking Information What do I need to do? If you're coming to campus by car, then you to the University and provide them with your name and car registration details). Please ensure you receive from one of our machines which are situated in the car parks. Do I need to pay? Yes, 30p per hour or Ł2

  2. Moongyu Park's Recent Papers

    E-print Network

    (M. Park) Stability analysis and error estimate of flowfield-dependent ... for first order linear hyperbolic equations, Journal of Computational and Applied ... (M. Park, D. O'Malley and J.H. Cushman) Generalized Similarity/Renormalization Groups ... "Stability Analysis of VEISV Propagation Modeling for Network Worm Attach", ...

  3. Splendor In The Parks.

    ERIC Educational Resources Information Center

    Smith, Anthony Wayne

    1979-01-01

    Civilization is more and more intruding on the esthetic and recreational resources of the National Park System. Increased attention must be paid to controlling noise, pollution, and even the effects of urban lighting which detract from the enjoyment of the parks. (RE)

  4. Florida State Parks

    NSDL National Science Digital Library

    The modern Florida State Parks system was created in 1935, and their programs include parks all the way from the St. Augustine area to the Keys. Their homepage brings together cultural, historical, and scientific materials related to the various sites in the state system. The website includes information on each park, along with interactive features on African American sites in the state and notable battlegrounds. Along the top of the page, visitors can use sections such as "Find a Park" and "Stay the Night" to plan their journey through the state. Each park entry also contains information about the site's history, along with detailed information about ranger programs, special music events, and so on. Finally, visitors can stay in touch via Twitter and other social media.

  5. Interleukin-13 (IL-13) Pathway

    NSDL National Science Digital Library

    Ann Kelly-Welch (Marlene and Stewart Greenebaum Cancer Center and University of Maryland; Program in Oncology and Department of Microbiology and Immunology REV)

    2005-07-19

    Interleukin-13 (IL-13), like IL-4, is a cytokine produced by TH2 type helper T cells in response to signaling through the T cell antigen receptor and by mast cells and basophils upon cross-linkage of the high-affinity receptor for immunoglobulin E (IgE). It is also produced by activated eosinophils. IL-13 induces many of the same responses as IL-4 and shares a receptor subunit with IL-4. IL-13 has been implicated in airway hypersensitivity and mucus hypersecretion, inflammatory bowel disease, and parasitic nematode expulsion.

  6. Il Sistema BEATRIX per il Riconoscimento Automatico di Testi Manoscritti

    E-print Network

    Reyneri, Leonardo

    Il Sistema BEATRIX per il Riconoscimento Automatico di Testi Manoscritti B. Lazzerini, F riconoscimento automatico dei testi manoscritti, costituito da due sottosistemi fortemente interagenti, basati esempio sfruttando la ridondanza presente nella maggior parte dei testi manoscritti tipicamente tutti i

  7. Parking Arrangements for Special Events Parking & Transportation Services: T-1400

    E-print Network

    de Lijser, Peter

    Parking Arrangements for Special Events Parking & Transportation Services: T-1400 Phone: (657) 278(s) & number of spaces below in additional notes section) Yes No · Will you require parking permits in advance? (Cost to guest $8.00 per vehicle) Yes No · Would you require a parking attendant to issue permits

  8. UVA Parking and Transportation Student Parking Application Form

    E-print Network

    Acton, Scott

    UVA Parking and Transportation Student Parking Application Form Please Print Clearly: Primary other than yourself, a parent, or spouse. Only one vehicle per family or carpool may park in permit areas at the same time unless full fees have been paid for each vehicle. Please notify Parking

  9. Dipartimento di Informatica Il Direttore

    E-print Network

    Guidoni, Leonardo

    : Daniele Venturi punti complessivi 90 Sotto condizione dell'accertamento dei requisiti prescritti per l'ammissione al concorso di cui sopra, il Dott. Daniele Venturi, nato a Roma il 29.06.1983, č dichiarato vincitore

  10. Seminal levels of IL-10, IL-12, and IL-17 in men with asymptomatic chlamydia infection.

    PubMed

    Hakimi, Hamid; Akhondi, Mohammad Mehdi; Sadeghi, Mohammad Reza; Chamani, Leila; Arababadi, Mohammad Kazemi; Ahmadabadi, Behzad Nasiri; Hassanshahi, Gholamhossein; Fathollahi, Mahmoud Sheikh

    2014-02-01

    Chlamydia trachomatis, as an obligate intracellular parasite, usually causes asymptomatic genital tract infections in both men and women with several complications. The role of C. trachomatis infection in the secretion of a number of interleukins (ILs) from epithelial cells has been established by in vitro studies performed on various cell lines. The aim of this study was to detect the seminal levels of IL-10, IL-12, and IL-17 in men with asymptomatic chlamydia infection. Our case group study included 50 semen samples being PCR-positive for C. trachomatis from 585 semen samples and the ELISA method was applied for detection of IL-10, IL-12, and IL-17. Our results demonstrated that the semen levels of IL-10 and IL-17 were significantly increased, while IL-12 was decreased in C. trachomatis-infected patients. According to these results, it may be concluded that the increased and decreased semen levels of IL-10 and IL-12, respectively, lead to impaired immune responses against C. trachomatis. Increased semen levels of IL-17 may also be associated with the pathogenesis of C. trachomatis infection. PMID:23996104

  11. FORESTS FORTHE WORLD PARK RESERVATIONS

    E-print Network

    Northern British Columbia, University of

    ETIQUETTE s Stoop and Scoop s Share the Park s Train Your Dog s Licence Your Dog s Respect the WildlifeFORESTS FORTHE WORLD PARK RESERVATIONS Park sites are perfect for special events, such as group picnics, community events, weddings, and photos. A park use permit reserves your date, time, and place, so

  12. PARKING PERMITS Conditions of Issue

    E-print Network

    Martin, Ralph R.

    PARKING PERMITS Conditions of Issue 1. Parking permits for the Academic year 2012/2013 will cease to be valid on 1 st October 2013. Parking permits for the Academic year 2013/2014 will be valid immediately with the car parking regulations and conditions of issue of the University and may be withdrawn by the Director

  13. Parking Services VEHICLE OPERATOR REGISTRATION

    E-print Network

    Suzuki, Masatsugu

    Parking Services VEHICLE OPERATOR REGISTRATION PLEASE PRINT AND COMPLETE BOTH SIDES. Last name-School Volunteer NOTE: Registration decal and/or parking permit must be displayed in accordance with the parking of Binghamton University, which are available at the Parking Services Office, the Information Booth, and on

  14. Discrete Time Lagrangian Mechanics on Lie Groups,¶with an Application to the Lagrange Top

    Microsoft Academic Search

    A. I. Bobenko; Yu. B. Suris

    1999-01-01

    :  We develop the theory of discrete time Lagrangian mechanics on Lie groups, originated in the work of Veselov and Moser, and\\u000a the theory of Lagrangian reduction in the discrete time setting. The results thus obtained are applied to the investigation\\u000a of an integrable time discretization of a famous integrable system of classical mechanics – the Lagrange top. We recall the

  15. Adaptive nonlinear control of spacecraft near sun-earth L2 lagrange point

    Microsoft Academic Search

    Hong Wong; Vikram Kapila

    2003-01-01

    In this paper, an adaptive control algorithm is presented to enable a spacecraft to track desired trajectories near the Lz Lagrange point in the Sun-Earth system. An adaptive full-state feedback control law, designed using a Lyapunov-type analysis, exhibits globally asymptotic position tracking in the presence of the unknown spacecraft mass. The control law is simulated for a Lyapunov orbit in

  16. Free-Lagrange simulations of the expansion and jetting collapse of air bubbles in water

    Microsoft Academic Search

    C. K. Turangan; A. R. Jamaluddin; G. J. Ball; T. G. Leighton

    2008-01-01

    A free-Lagrange numerical method is implemented to simulate the axisymmetric jetting collapse of air bubbles in water. This is performed for both lithotripter shock-induced collapses of initially stable bubbles, and for free-running cases where the bubble initially contains an overpressure. The code is validated using two test problems (shock-induced bubble collapse using a step shock, and shock10 MPa tensile waves,

  17. Lagrange\\/Vandermonde MUI eliminating user codes for quasi-synchronous CDMA in unknown multipath

    Microsoft Academic Search

    Anna Scaglione; Georgios B. Giannakis; Sergio Barbarossa

    2000-01-01

    A family of codes for low-complexity quasi-synchronous code division multiple access (CDMA) systems is developed in order to eliminate multiuser interference (MUI) completely in the presence of unknown and even rapidly varying multipath. Judiciously designed precomputable symbol-periodic user codes, which we term Lagrange or Vandermonde, and the corresponding linear receivers offer a generalization of orthogonal frequency division multiplexing (OFDM), which

  18. Kruger National Park

    Atmospheric Science Data Center

    2013-04-15

    ... above and to the right of image center is the Palabora Copper Mine, and the water body near upper right is Lake Massingir in ... South Africa showing Kruger Park, the Palabora Copper Mine, and Lake Massingir. project:  MISR ...

  19. High School Parking Lots.

    ERIC Educational Resources Information Center

    Neff, Thomas G.

    2002-01-01

    Describes the reorganization of the site of Ben Davis High School in Wayne Township, Indiana as an example of improvements to school parking lot design and vehicle/pedestrian traffic flow and security. Includes design drawings. (EV)

  20. Jurassic Park Safety Audit

    NSDL National Science Digital Library

    Using the first 30 minutes of the film Jurassic Park, the student will audit it for violations of safety rules and regulations, OSHA violations, and violations of HASP's. Access to the activity required free and quick registration with ATEEC.

  1. New IL12-family members: IL23 and IL27, cytokines with divergent functions

    Microsoft Academic Search

    Christopher A. Hunter

    2005-01-01

    Understanding the factors that influence T helper 1 (TH1)- and TH2-cell responses has been one of the main focuses of immunology for almost 20 years. Whereas the central role of interleukin-12 (IL-12) in the generation of TH1 cells has long been appreciated, subsequent studies indicated that IL-23 and IL-27, two cytokines that are closely related to IL-12, also regulate TH1-cell

  2. Geology Fieldnotes: Great Basin National Park, Nevada

    NSDL National Science Digital Library

    This Great Basin National Park site contains park geology information, park maps, visitor information, and teacher features (educational resources and links for teaching geology using National Park examples). The park geology section discusses the region's biogeography, glacial history, and the Lehman Caves. A park map and a features/relief map of the Great Basin National Park are included.

  3. PARKING POLICY FOR THE LOWER PARKING DECK IN FENSTER HALL The parking garage located in the lower level of the parking structure below Fenster Hall

    E-print Network

    PARKING POLICY FOR THE LOWER PARKING DECK IN FENSTER HALL The parking garage located in the lower level of the parking structure below Fenster Hall will consist of both assigned and open parking spaces. Parking spaces in this facility shall be allocated in the following manner: 1. Assigned parking spaces

  4. updated August 1, 2012 -Motorcycle Parking

    E-print Network

    Meyers, Steven D.

    11 updated August 1, 2012 - Motorcycle Parking - Loading Dock Area - Parking Pay Station - Disabled Parking - Metered Parking Campus Districts Academics Athletics Residence Halls R&D Park Health Services Support Services Daily/Visitor Parking Hourly Parking 18B Varsity Tennis Courts Stadium STA Softball

  5. Tour of Park Geology: Oldest Rocks

    NSDL National Science Digital Library

    This park geology site provides links to tours of individual National Parks, Monuments, and Recreation Areas with the oldest known rocks. The parks are divided at this site into East and West. Where appropriate, for each park, links are provided to park geology, maps, photographs, geologic research, visitor information, multimedia resources, and teacher features (resources for teaching geology using National Park examples). Parks listed include: Voyaguers National Park, Keweenaw National Historic Park, Lake Meade National Recreation Area, and many more.

  6. Park Geology: Tour of Basin and Range Parks

    NSDL National Science Digital Library

    This site provides links to tours of individual National Parks within the Basin and Range region. Where appropriate for each park, links are provided to park geology, maps, photographs, geologic research, related links, visitor information, multimedia resources, and teacher features. Some of the parks have an expanded geology page that features the geologic time, history, plate tectonics, rocks and minerals, and a virtual field trip of the park. Of particular note is the teacher feature section, which provides educational resources and links for teaching geology with National Park examples.

  7. Terrain Park Injuries

    PubMed Central

    Moffat, Craig; McIntosh, Scott; Bringhurst, Jade; Danenhauer, Karen; Gilmore, Nathan; Hopkins, Christy L.

    2009-01-01

    Background: This study examined demographics, injury pattern, and hospital outcome in patients injured in winter resort terrain parks. Methods: The study included patients ?12 years of age who presented to a regional trauma center with an acute injury sustained at a winter resort. Emergency department (ED) research assistants collected patient injury and helmet use information using a prospectively designed questionnaire. ED and hospital data were obtained from trauma registry and hospital records. Results: Seventy-two patients were injured in a terrain park, and 263 patients were injured on non-terrain park slopes. Patients injured in terrain parks were more likely to be male [68/72 (94%) vs. 176/263 (67%), p<0.0001], younger in age [23 ± 7 vs. 36 ± 17, p<0.0001], live locally [47/72 (65%) vs. 124/263 (47%), p=0.006], use a snowboard [50/72 (69%) vs. 91/263 (35%), p<0.0001], hold a season pass [46/66 (70%) vs. 98/253 (39%), p<0.0001], and sustain an upper extremity injury [29/72 (40%) vs. 52/263 (20%), p<0.001] when compared to patients injured on non-terrain park slopes. There were no differences between the groups in terms of EMS transport to hospital, helmet use, admission rate, hospital length of stay, and patients requiring specialty consultation in the ED. Conclusions: Patients injured in terrain parks represent a unique demographic within winter resort patrons. Injury severity appears to be similar to those patients injured on non-terrain park slopes. PMID:20046245

  8. Expansion of human NK-22 cells with IL-7, IL-2, and IL-1? reveals intrinsic functional plasticity

    PubMed Central

    Cella, Marina; Otero, Karel; Colonna, Marco

    2010-01-01

    Natural killer-22 (NK-22) cells are a human NK cell subset situated in mucosal-associated lymphoid tissues that specialize in IL-22 secretion in response to IL-23. Here we investigated the cytokine requirements for NK-22 cell expansion. IL-7 maintained the sur-vival of NK-22 cells and IL-22 production in response to IL-23 but was insufficient to induce robust expansion. Proliferation of NK-22 cells was increased markedly by adding either IL-1? or IL-2 to IL-7 and was even stronger in the presence of IL-1? plus IL-2. In contrast to IL-7, continuous culture in IL-1? and IL-2 modified NK-22 cytokine profiles. IL-1? promoted constitutive IL-22 secretion rather than acute IL-22 production in response to IL-23 and induced IL-17 in some cells. IL-2 reduced secretion of IL-22 and IL-17, increasing production of IFN-? and leukemia inhibitory factor. Functional deviation toward IFN-? production also was induced by continuous culture in IL-23. These results demonstrate the functional plasticity of NK-22 cells, which may allow flexible responses to different pathogens. Finally, we found that NK-22 cells released the B-cell survival factor, B-cell activating factor belonging to the TNF family (BAFF), suggesting a potential role of NK-22 cells in promoting B-cell–mediated mucosal immunity. PMID:20534450

  9. Parking management tactics. Volume 3: reference guide. [Parking

    SciTech Connect

    DiRenzo, J.F.; Cima, B.; Barber, E.

    1981-06-01

    Information contained in this guide was formulated from parking management experiences of 20 cities previously investigated and documented. The guide provides information on the planning, implementation, and operation of six types of parking management tactics: on-street parking supply tactics, off-street parking supply tactics for activity centers, fringe and corridor parking facilities, pricing tactics, enforcement and adjudication tactics, and marketing tactics. The guide assesses the essential aspects of the tactics as well as presents some useful analysis procedures for evaluating parking management actions. The Reference Guide is a stand-alone document for use by transportation planners and traffic engineers. It is the third volume of a three-volume series of reports on parking management. The first volume, entitled Overview, is designed for management. The second volume, entitled Overview and Case Studies, is designed for technical staff or managers who want detailed city-by-city information on parking management tactics.

  10. Garage Parking n Visitors may park in garages

    E-print Network

    Raizen, Mark G.

    kcolluBboB etatSsaxeT yrotsiH muesuM etatSsaxeT lotipaC Garage Parking n Visitors may park in garages at the hourly rate n All parking garages are open 24/7 on a space-available basis for visitors and students and do not require a permit Garage Parking Rates* 0 - 30 minutes No Charge 30 minutes - 1 hour $ 3

  11. Parking Structures and the Space Race.

    ERIC Educational Resources Information Center

    Milshtein, Amy

    2000-01-01

    Presents some solutions to overcrowded parking on college campuses. Tips on selecting sites for parking garages, making parking decks blend with adjacent communities, and turning parking garages into multi use facilities are addressed. (GR)

  12. Geology of National Parks

    NSDL National Science Digital Library

    Have you ever wondered what it would be like to take a historic tour of the Colorado River Canyon? Wonder no more, as this site from the U.S. Geological Survey makes just such a sojourn possible. Drawing on thousands of historic and contemporary photographs, views, documents, and other items, the USGS has created these fine 3D and photographic tours of dozens of national parks. On the site, visitors will find an alphabetical list of the parks, along with links to the 3D image galleries, standard image galleries, and selected online field guides. There's a great deal to recommend here, but visitors should definitely look at the stereograph images from the Powell Survey Expeditions of the Colorado River from 1871 and 1872 (in the "Other park-related resources" section) and the guidebook titled "Where's the San Andreas Fault?" Along with providing entertaining edification, this site might also spark some ideas for an upcoming trip.

  13. Finding Pulsars at Parkes

    E-print Network

    R. N. Manchester

    2000-09-26

    There are many reasons why it is important to increase the number of known pulsars. Not only do pulsar searches continue to improve statistical estimates of, for example, pulsar birthrates, lifetimes and the Galactic distribution, but they continue to turn up interesting and, in some cases, unique individual pulsars. In the early days of pulsar astronomy, the Molonglo radio telescope led the world as a pulsar detection instrument. However, the Parkes radio telescope, with its frequency versatility and greater tracking ablility, combined with sensitive receivers and powerful computer detection algorithms, is now the world's most successful telescope at finding pulsars. The Parkes multibeam survey, begun in 1997, by itself will come close to doubling the number of known pulsars. Parkes has also been very successful at finding millisecond pulsars, especially in globular clusters. One third of the known millisecond pulsars have been found in just one cluster, 47 Tucanae.

  14. The IL-23-IL-17 axis in inflammatory arthritis.

    PubMed

    Lubberts, Erik

    2015-07-01

    The discovery that the IL-23-IL-17 immune pathway is involved in many models of autoimmune disease has changed the concept of the role of T-helper cell subsets in the development of autoimmunity. In addition to TH17 cells, IL-17 is also produced by other T cell subsets and innate immune cells; which of these IL-17-producing cells have a role in tissue inflammation, and the timing, location and nature of their role(s), is incompletely understood. The current view is that innate and adaptive immune cells expressing the IL-23 receptor become pathogenic after exposure to IL-23, but further investigation into the role of IL-23 and IL-17 at different stages in the development and progression of chronic (destructive) inflammatory diseases is needed. Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are the two most common forms of chronic immune-mediated inflammatory arthritis, and the IL-23-IL-17 axis is thought to have a critical role in both. This Review discusses the basic mechanisms of these cytokines in RA and SpA on the basis of findings from disease-specific animal models as well as human ex vivo studies. Promising therapeutic applications to modulate this immune pathway are in development or have already been approved. Blockade of IL-17 and/or TH17-cell activity in combination with anti-TNF therapy might be a successful approach to achieving stable remission or even prevention of chronic immune-mediated inflammatory diseases. PMID:25907700

  15. 2012-13 UT Basketball Parking Information Campus Parking: On weekdays, the majority of parking on campus requires a basketball

    E-print Network

    Tennessee, University of

    2012-13 UT Basketball Parking Information Campus Parking: On weekdays, the majority of parking on campus requires a basketball parking permit beginning at 4:00pm.* On weekends, the same is true but times will vary depending on the tip-off time for the game. Public Parking: Free public parking with shuttle

  16. Hawaii hydrogen power park Hawaii Hydrogen Power Park

    E-print Network

    Hawaii hydrogen power park H Hawaii Hydrogen Power Park 2003 Hydrogen & Fuel Cells Merit Review Meeting 19-22 May 2003 Maurice Kaya, PI, State of Hawaii Dr. Rick Rocheleau, PI, University of Hawaii Mitch Ewan, Project Manager, University of Hawaii #12;Hawaii hydrogen power park H Objectives

  17. IL15R? Recycles and Presents IL15 In trans to Neighboring Cells

    Microsoft Academic Search

    Sigrid Dubois; Jennifer Mariner; Thomas A Waldmann; Yutaka Tagaya

    2002-01-01

    We report intriguing aspects of the contribution of IL-15R? to IL-15 functions. Consistent with high-affinity interactions between IL-15 and IL-15R?, these two molecules form stable complexes on the cell surface of activated monocytes. The formation of IL-15\\/IL-15R? complexes on cell surfaces induces a trans-endosomal recycling of IL-15 leading to the persistence of surface-bound IL-15 due to the constantreappearance of IL-15

  18. MIDDLE PARK Conservation Action Plan

    E-print Network

    MIDDLE PARK Conservation Action Plan 2011 Update Plant Species of Focus: Kremmling milkvetch Conservation Initiative Workshop dates: June 26, 2008 and July 6, 2010 Report date: August 25, 2011 Middle Park................................................................................................................... 6 A. Conservation Targets

  19. NASA Research Park

    NSDL National Science Digital Library

    A massive addition to the NASA Ames Research Park is detailed on this site. Although the project is not scheduled to be completed until 2015, it has been in the planning stages for several years and 2003 marks the beginning of Phase 1. The 98-page NASA Ames Development Plan is available for public viewing online. The new facilities will be designed to accommodate research in "information technology, nanotechnology, biotechnology, and astrobiology." Several other news articles and formal documents about the project can be downloaded as well. The design, construction, and staffing of the new research park will reportedly generate 7,000 high-tech jobs.

  20. Download the Campus Parking Map

    E-print Network

    Zakharov, Vladimir

    Download the Campus Parking Map to your Smartphone B C D E F 8 7 6 5 4 3 2 1 A E. Speedway Blvd. EAve. ParkAve. South Campus Dr. Enke Dr. EuclidAve. ParkAve. ONE WAY VineAve. CherryAve.CherryAve. WarrenAve.WarrenAve. CherryAve. MartinAve. ParkAve. MountainAve. HighlandAve. VineAve. TyndallAve.TyndallAve. Warren

  1. IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1.

    PubMed

    Heinemann, Christina; Heink, Sylvia; Petermann, Franziska; Vasanthakumar, Ajithkumar; Rothhammer, Veit; Doorduijn, Elien; Mitsdoerffer, Meike; Sie, Christopher; Prazeres da Costa, Olivia; Buch, Thorsten; Hemmer, Bernhard; Oukka, Mohamed; Kallies, Axel; Korn, Thomas

    2014-01-01

    Central nervous system (CNS) autoimmunity is regulated by the balance of pro-inflammatory cytokines and IL-10. Here we identify the transcriptional regulator Blimp1 as crucial to induce IL-10 in inflammatory T helper cells. Pre-committed Th17 cells respond to IL-27 and IL-12 by upregulating Blimp1 and adopt a Tr-1-like phenotype characterized by IL-10 and IFN-? production. Accordingly, Blimp1-deficient effector T cells fail to produce IL-10, and deficiency in Tr-1 cell function leads to uncontrolled Th17 cell-driven CNS pathology without the need to stabilize the Th17 phenotype with IL-23. IL-23 counteracts IL-27 and IL-12-mediated effects on Tr-1-development reinforcing the pro-inflammatory phenotype of Th17 cells. Thus, the balance of IL-23 vs IL-12/IL-27 signals into CD4(+) effector T cells determines whether tissue inflammation is perpetuated or resolves. PMID:24796719

  2. The Lagrange Points in a Binary Black Hole System: Applications to Electromagnetic Signatures

    NASA Technical Reports Server (NTRS)

    Schnittman, Jeremy

    2010-01-01

    We study the stability and evolution of the Lagrange points L_4 and L-5 in a black hole (BH) binary system, including gravitational radiation. We find that gas and stars can be shepherded in with the BH system until the final moments before merger, providing the fuel for a bright electromagnetic counterpart to a gravitational wave signal. Other astrophysical signatures include the ejection of hyper-velocity stars, gravitational collapse of globular clusters, and the periodic shift of narrow emission lines in AGN.

  3. Telleparallel Lagrange Geometry and a Unified Field Theory: Linearization of the Field Equations

    E-print Network

    M. I. Wanas; Nabil L. Youssef; A. M. Sid-Ahmed

    2011-07-03

    The present paper is a natural continuation of our previous paper: "Teleparallel Lagrange geometry and a unified field theory, Class. Quantum Grav., 27 (2010), 045005 (29pp)" \\cite{WNA}. In this paper, we apply a linearization scheme on the field equations obtained in \\cite{WNA}. Three important results under the linearization assumption are accomplished. First, the vertical fundamental geometric objects of the EAP-space loose their dependence on the positional argument $x$. Secondly, our linearized theory in the Cartan-type case coincides with the GFT in the first order of approximation. Finally, an approximate solution of the vertical field equations is obtained.

  4. Taylor-Lagrange renormalization scheme, Pauli-Villars subtraction, and light-front dynamics

    SciTech Connect

    Grange, P.; Mutet, B. [Laboratoire de Physique Theorique et Astroparticules, Universite Montpellier II, CNRS/IN2P3, Place E. Bataillon, F-34095 Montpellier Cedex 05 (France); Mathiot, J.-F. [Clermont Universite, Laboratoire de Physique Corpusculaire, BP10448, F-63000 Clermont-Ferrand (France); Werner, E. [Institut fr Theoretische Physik, Universitt Regensburg, Universittstrasse 31, D-93053 Regensburg (Germany)

    2010-07-15

    We show how the recently proposed Taylor-Lagrange renormalization scheme can lead to extensions of singular distributions which are reminiscent of the Pauli-Villars subtraction. However, at variance with the Pauli-Villars regularization scheme, no infinite mass limit is performed in this scheme. As an illustration of this mechanism, we consider the calculation of the self-energy in second order perturbation theory in the Yukawa model, within the covariant formulation of light-front dynamics. We show, in particular, how rotational invariance is preserved in this scheme.

  5. A new approach on fractional variational problems and Euler-Lagrange equations

    NASA Astrophysics Data System (ADS)

    Bahrami, F.; Fazli, H.; Jodayree Akbarfam, A.

    2015-06-01

    In this paper we generalize fractional variational problems in [ a, b ] . We allow for the possibility that functions in the space of solution for the optimization problem can blow up at boundary points. The appropriate fractional derivative spaces are introduced and a compact embedding theorem demonstrated. We prove the existence of minimizers for the variational problems which satisfy the Euler-Lagrange equations with Riemann-Liouville boundary conditions. Our method is based on the fractional calculus of variations. An example is given to illustrate the results.

  6. Riemann-Lagrange Geometric Dynamics for the Multi-Time Magnetized Non-Viscous Plasma

    E-print Network

    Neagu, Mircea

    2010-01-01

    In this paper, using Riemann-Lagrange geometrical methods, we construct a geometrical model on 1-jet spaces for the study of multi-time relativistic magnetized non-viscous plasma, characterized by a given energy-stress-momentum distinguished (d-) tensor. In that arena, we give the conservation laws and the continuity equations for multi-time plasma. The partial differential equations of the stream sheets (the equivalent of stream lines in the classical semi-Riemannian geometrical approach of plasma) for multi-time plasma are also written.

  7. Pay-N-Display Surface Lot Parking

    E-print Network

    Pay-N-Display Surface Lot Parking Ohio Stadium Tuttle Park Place Garage · Participants will be asked to park at either Tuttle Park Place Garage or on the southeast side of Ohio Stadium. Both parking. · If choosing to park in the Tuttle garage, participants will be charged an hourly rate, which

  8. Visitor Parking at the Gilman Parking Structure The UC San Diego visitor parking lot closest to the workshop is the Gilman Parking Structure, located at

    E-print Network

    Visitor Parking at the Gilman Parking Structure The UC San Diego visitor parking lot closest to the workshop is the Gilman Parking Structure, located at the corner of Gilman Drive and Russell Drive, La Jolla, CA 92093. http://wikimapia.org/523784/GilmanParkingStructure The Gilman Parking Structure has Pay

  9. Parking Pass Move-In 2014

    E-print Network

    Walker, Matthew P.

    Parking Pass Move-In 2014 This Parking Pass is for students moving into the Residence Halls for Fall 2014. · This parking pass is only valid in designated UniveRsiTy locaTions. · Do noT leave. · Drivers must obey all parking regulations (e.g. only drivers with a disabled parking permit may park

  10. UC Berkeley 1 Bancroft Center Parking

    E-print Network

    Jacobs, Lucia

    PP UC Berkeley 2 2 3 3 4 4 1 1 Bancroft Center Parking Inkstone Parking Garage Anna Head West Lot With 436 Spaces, this parking structure contains the most parking available next to campus. A cashier and parking machine is located on the bottom level, with most Telegraph merchants offering parking validation

  11. IL-1 and IL-23 Mediate Early IL-17A Production in Pulmonary Inflammation Leading to Late Fibrosis

    E-print Network

    Paris-Sud XI, Université de

    IL-1 and IL-23 Mediate Early IL-17A Production in Pulmonary Inflammation Leading to Late Fibrosis in the establishment of pulmonary inflammation and fibrosis in mice. Methods: The contribution of IL-23 or IL-17 in pulmonary inflammation and fibrosis was assessed using the bleomycin model in deficient mice. Results: We

  12. SouthCampus Clinic Parking

    E-print Network

    Oh, Kwang W.

    SouthCampus To Dow ntow n Cam pus Clinic Parking Zipcar space EOC M.W. Kapoor Hall Child Care-645-3943 · 106 Spaulding Quad Allen Hall Sherman Annex Allen Lot Foster Lot Squire Loop NFTA Park & Ride Lot) 6. Roswell Park Cancer Institute 5. Buffalo General 4. Parker Lot 3. Main Circle 2. Goodyear 1. Main

  13. Dry Tortugas National Park, Florida

    NSDL National Science Digital Library

    This National Park Service (NPS) publication discusses Dry Tortugas National Park in Florida. This system consists of 7 small islands off the coast of Key West. The site discusses the history of this area, as well as the marine setting of the park.

  14. Parking Services Rules and Regulations

    E-print Network

    Moore, Paul A.

    Parking Services Rules and Regulations 2013 ­ 2014 Academic Year / Summer #12;Table of Contents 1 Authority 3 1.1 Manager of Parking Services 3 1.2 Discretion and Authority 3 1.3 Authorization 3 1.4 Liability 3 2 Two Wheeled Vehicles 4 2.1 Motorcycles / Mopeds / Scooters 4 3 Parking Permits 4 3.1 General

  15. GOLER HOUSE/ WHIPPLE PARK

    E-print Network

    Mahon, Bradford Z.

    permits will not be allowed in the Goler House lot with the exception of the short-term spaces. Short-term spaces will be "30 minutes with flasher" parking ONLY for unloading pur- poses. Violators will be subject know your pick-up location when you call. Please be aware that shuttle response times may vary

  16. ( Underground ) TRW Parking

    E-print Network

    Maurer, Frank

    Lot 6 ( Public ) Lot 1 ( Public ) Lot 4 Lot 8a ( Public ) Lot 7 ( Staff ) Lot 10 ( Underground ) TRW Parking ( Underground ) Lot3(Staff) Lot 8 (Staff) HMRB TRW H R IC H SC MT PP SSB TBCC GW ST NT FMC Health Centre McCaig Tower North Tower PP SSB ST TBCC Physical Plant Special Services Building South

  17. The Clover Park Story

    ERIC Educational Resources Information Center

    Norris, Don

    1974-01-01

    Describes an aviation trades training program offered by the Clover Park schools in Washington which exposes students to all facets of the aviation industry from record keeping to air traffic control in addition to the specific skill of piloting the aircraft. (BR)

  18. Access into Campus & Parking

    E-print Network

    Bus Stops Sub Station Active Construction - No public access: Livingston Housing Construction SiteLSC Lot 105 Phase A Access into Campus & Parking Scarlet Lot RAC Livingston Campus Construction Informational Map May 2012 Livingston Housing Construction Site Road 3 Road Closed SSW Route18 Exit LSC Access

  19. KALELE ROAD Parking Office

    E-print Network

    Environ. Health Transportation Services Landscaping No Vehicle Access No Public Vehicle Access No Public High School 1 Everly Hall UH Parking Access & Mid-Pacific Institute Exit Stairs Pond Law Library Henke Vehicle Access Maile Kiosk Waialae Kiosk Office of Procurement, & Real Property Mgmt Lower Campus Entrance

  20. Yellowstone National Park

    NSDL National Science Digital Library

    Brieske, Joel A.

    2002-01-01

    Yellowstone National Park was established on March 1, 1872, as the first national park in the world. The overwhelming and unique beauty found in this natural wonder is truly difficult to describe.This Topic In Depth begin with the excellent National Park Service's (1) official Yellowstone Web Site, which contains the park's history, virtual field trips, park information, visitor guides, web cams, kids pages, and more. The next site offered by EarthTalk Studios is called Yellowstone Geographic. This extensive and graphically reliant site contains superb interactive activities related to the park and comes close to its goal of being "the best Yellowstone Web Site on the planet." The third site from UnMuseum.org called Weird Geology: Geysers explores the workings of Yellowstone's famous geysers with descriptions, photographs, illustrations, and a movie of an eruption. The next site from Exploratorium is a learning activity called Geyser: Cyclic Hot Water Fountain. With the help of their teacher, students build a working model of a geyser from common chemical equipment. From the University of Michigan, Meg Streepey's Geysers and the Earth's Plumbing Systems Web Site describes (for more advanced students) how geysers work, including how to analyze their thermal and hydrologic regimes. Another research site, from the University of Utah's College of Mines and Earth Sciences, is the GPS Surveys of the Yellowstone Hotspot and the Wasatch Fault, Utah. Objectives of the study are "to measure and understand the spatial and temporal variations of the crustal deformation produced by the interaction between lithospheric plate motion and the asthenospheric hotspot." The last two sites are from the USGS, the first of which is the Yellowstone River Basin National Water-Quality Assessment Program site. It contains a project description, available data, and other relevant information. The last site, Yellowstone Volcano Observatory, is a facility that is designed for observing volcanic and earthquake activity in the park. This site also contains a project description, volcanic data, maps, descriptions of volcanic rock, a frequently asked questions link, and more.

  1. Men's Basketball Parking 2011-2012 Free parking on a first come,

    E-print Network

    Acton, Scott

    Men's Basketball Parking 2011-2012 The Park Free parking on a first come, first served basis. Park and walk (20 min.), or ride free shuttle. Shuttleis accessible. Emmet/Ivy Parking Garage Park and Walk - 10 Minutes $5.00 per game as available. Parking Available on a first come, first served basis. Lots open 1

  2. Optimized Expression of IL-12 Cytokine Family

    Cancer.gov

    The IL-12 family of cytokines (IL-12, IL-23, and IL-27) plays a role in infection, inflammation and autoimmune diseases. IL-12 is produced by macrophages and dendritic cells in response to certain bacterial and parasitic infections and is a powerful inducer of IFN-gamma production.

  3. The Free-Lagrange method; Proceedings of the First International Conference, Hilton Head Island, SC, March 4-6, 1985

    NASA Astrophysics Data System (ADS)

    Fritts, M. J.; Crowley, W. P.; Trease, H.

    Various papers on the Free-Lagrange method are presented. Individual topics addressed include: Free-Lagrange methods for compressible hydrodynamics in two space dimensions; finite difference operators on unstructured triangular meshes; a Lagrangian method for the incompressible Navier-Stokes equations on a periodic domain; Free-Lagrangian methods, independent time steps, and parallel processing; three-dimensional algorithms for grid restructuring in Free-Lagrangian calculations; and three-dimensional Free-Lagrangian hydrodynamics. Also discussed are: a vectorized 'near neighbors' algorithm of order N using a monotonic logical grid; data structures and vectorization in a two-dimensional Free-Lagrangian code; solution adaptivity using a triangular mesh; recent developments in FEM-CFD; a conservative Free Lagrange code; and compressible Lagrangian hydrodynamics without Lagrangian cells.

  4. USGS: Geology in the Parks

    NSDL National Science Digital Library

    The US Geological Survey Geology in the Parks Web site is a cooperative project of the USGS Western Earth Surface Processes Team and the National Park Service. This extensive site covers geologic maps, plate tectonics, rocks and minerals, geologic time, US geologic provinces, park geology of the Mojave, Sunset Crater, Lake Mead, North Cascades, Death Valley, Yosemite National Park, and much more. Descriptions, graphics, photographs, and animations all contribute to this informative and interesting Web site making it a one stop, all encompassing, resource for everything geology and US national park related.

  5. Augmented Lagrange Hopfield network for solving economic dispatch problem in competitive environment

    NASA Astrophysics Data System (ADS)

    Vo, Dieu Ngoc; Ongsakul, Weerakorn; Nguyen, Khai Phuc

    2012-11-01

    This paper proposes an augmented Lagrange Hopfield network (ALHN) for solving economic dispatch (ED) problem in the competitive environment. The proposed ALHN is a continuous Hopfield network with its energy function based on augmented Lagrange function for efficiently dealing with constrained optimization problems. The ALHN method can overcome the drawbacks of the conventional Hopfield network such as local optimum, long computational time, and linear constraints. The proposed method is used for solving the ED problem with two revenue models of revenue based on payment for power delivered and payment for reserve allocated. The proposed ALHN has been tested on two systems of 3 units and 10 units for the two considered revenue models. The obtained results from the proposed methods are compared to those from differential evolution (DE) and particle swarm optimization (PSO) methods. The result comparison has indicated that the proposed method is very efficient for solving the problem. Therefore, the proposed ALHN could be a favorable tool for ED problem in the competitive environment.

  6. Sharing of the Interleukin2 (IL2) Receptor gamma Chain Between Receptors for IL2 and IL4

    Microsoft Academic Search

    Motonari Kondo; Toshikazu Takeshita; Naoto Ishii; Masataka Nakamura; Sumiko Watanabe; Ken-Ichi Arai; Kazuo Sugamura

    1993-01-01

    The gamma chain of the interleukin-2 (IL-2) receptor is an indispensable subunit for IL-2 binding and intracellular signal transduction. A monoclonal antibody to the gamma chain, TUGm2, inhibited IL-2 binding to the functional IL-2 receptors and also inhibited IL-4-induced cell growth and the high-affinity binding of IL-4 to the CTLL-2 mouse T cell line. Another monoclonal antibody, TUGm3, which reacted

  7. 77 FR 53826 - Special Regulations; Areas of the National Park System, Yellowstone National Park

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-04

    ...Box 168, Yellowstone National Park, WY 82190. ...Office, Headquarters Building, Mammoth Hot Springs, Yellowstone National Park, Wyoming. All...Office, Headquarters Building, Yellowstone National Park,...

  8. Lincoln Park Architectural Photographs

    NSDL National Science Digital Library

    Harold, Wanda

    2012-01-13

    The Lincoln Park neighborhood in Chicago is home to a number of architectural landmarks, including 19th century mansions with bold mansard roofs, a former seminary on the grounds of DePaul University, and other delights. In 2000, DePaul sociologist Wanda Harold set out to photograph a number of these unique structures. This digital collection includes 200 of her images, and this project was made possible in part through a grant from the Library Services and Technology Act. First-time visitors can get started by using a clickable map of Lincoln Park to explore the photos, and they can also browse around by architect or street. Visitors shouldn't miss the photos of the workers' cottages at 1756 N. Clybourn and 2715 N. Kenmore Avenue. Overall, the site is a nice resource for students of Chicago architecture and urban geography.

  9. Mars parking orbit selection

    NASA Technical Reports Server (NTRS)

    Desai, Prasun N.; Braun, Robert D.

    1990-01-01

    For a Mars mission, the selection of a parking orbit is greatly influenced by the precession caused by the oblateness of the planet. This affects the departure condition for earth return, and therefore, the mass required in LEO for a Mars mission. In this investigation, minimum LEO mass penalties were observed for parking orbits characterized by having near-equatorial inclinations, high eccentricities, and requiring a three-dimensional departure burn. However, because near-equatorial inclination orbits have poor planetary coverage characteristics, they are not desirable from a science viewpoint. To enhance these science requirements along with landing-site accessibility, a penalty in initial LEO mass is required. This study shows that this initial LEO mass penalty is reduced for orbits characterized with low to moderate eccentricities, nonequatorial inclinations, and a tangential periapsis arrival and departure burn.

  10. Neighborhood Park Use by Children

    PubMed Central

    Dunton, Genevieve Fridlund; Almanza, Estela; Jerrett, Michael; Wolch, Jennifer; Pentz, Mary Ann

    2014-01-01

    Background While having a greater number of neighborhood parks may be associated with greater overall physical activity in children, information is lacking about the extent to which children actually use parks for physical activity. Purpose This study combined accelerometer, GPS, GIS, and self-report methods to examine neighborhood park availability, perceived proximity, and use for physical activity in children. Methods Low-to-middle income children (aged 8–14 years) (n=135) from suburban communities in Southern California wore an Actigraph accelerometer and GlobalSat BT-335 GPS device across 7 days to measure physical activity and park use, respectively. ArcGIS identified parks within a 500m residential buffer of children’s homes. Parents reported perceptions of neighborhood park proximity through the Neighborhood Environment Walkability Survey (NEWS). Data were collected from March 2009 to December 2010, and analyzed in 2013. Results Fifty-four percent of families lived within 500m of a park. Of these children, GPS data indicated that 16% used it more than 15 minutes and an additional 11% of children used it between 5 and 15 minutes during the 7-day study period. The odds of extended park use (>15 minutes) increased fourfold when the distance between home and the nearest neighborhood park decreased by 100 meters. Additionally, the odds of any park use (>5 minutes) doubled when moving from the 25th to the 75th percentile for park greenness/vegetation density. Conclusions Although children’s use of neighborhood parks was generally low, it increased substantially when parks were closer to children’s homes and had greater vegetation density. PMID:24439346

  11. A Lagrange multiplier mixed finite element formulation for three-dimensional contact of biphasic tissues.

    PubMed

    Yang, Taiseung; Spilker, Robert L

    2007-06-01

    A three-dimensional (3D) contact finite element formulation has been developed for biological soft tissue-to-tissue contact analysis. The linear biphasic theory of Mow, Holmes, and Lai (1984, J. Biomech., 17(5), pp. 377-394) based on continuum mixture theory, is adopted to describe the hydrated soft tissue as a continuum of solid and fluid phases. Four contact continuity conditions derived for biphasic mixtures by Hou et al. (1989, ASME J. Biomech. Eng., 111(1), pp. 78-87) are introduced on the assumed contact surface, and a weighted residual method has been used to derive a mixed velocity-pressure finite element contact formulation. The Lagrange multiplier method is used to enforce two of the four contact continuity conditions, while the other two conditions are introduced directly into the weighted residual statement. Alternate formulations are possible, which differ in the choice of continuity conditions that are enforced with Lagrange multipliers. Primary attention is focused on a formulation that enforces the normal solid traction and relative fluid flow continuity conditions on the contact surface using Lagrange multipliers. An alternate approach, in which the multipliers enforce normal solid traction and pressure continuity conditions, is also discussed. The contact nonlinearity is treated with an iterative algorithm, where the assumed area is either extended or reduced based on the validity of the solution relative to contact conditions. The resulting first-order system of equations is solved in time using the generalized finite difference scheme. The formulation is validated by a series of increasingly complex canonical problems, including the confined and unconfined compression, the Hertz contact problem, and two biphasic indentation tests. As a clinical demonstration of the capability of the contact analysis, the gleno-humeral joint contact of human shoulders is analyzed using an idealized 3D geometry. In the joint, both glenoid and humeral head cartilage experience maximum tensile and compressive stresses are at the cartilage-bone interface, away from the center of the contact area. PMID:17536914

  12. An exploration of the relationship between use of parks and access, park appeal, and communication effectiveness 

    E-print Network

    Walker, Jamie Rae

    2009-05-15

    Understanding what variables influence park use would assist park providers and policy makers in acquiring, designing, managing, and funding initiatives which encourage or support park use. Previous studies indicate that access to parks (measured...

  13. Parking Policies 1. The University's Parking Regulations, Policies and Procedures ("Policies")

    E-print Network

    Hong, Jason I.

    Policies - 1 - Parking Policies 1. The University's Parking Regulations, Policies and Procedures or operated on University property. The Parking & Transportation Office issues permits only to members the fees charged for parking permits and all costs or penalties associated with violations

  14. Interleukin-4 (IL-4) Pathway

    NSDL National Science Digital Library

    Ann Kelly-Welch (University of Maryland and Stewart Greenebaum Cancer Center; Program in Oncology at Marlene and Department of Microbiology and Immunology REV)

    2005-07-19

    Interleukin-4 (IL-4) is a cytokine produced by TH2 type helper T cells and by mast cells, basophils, and eosinophils. This cytokine can elicit many responses, some of which are associated with allergy and asthma. Studies with long-term cell lines and primary cells have revealed differences in the signaling between these two experimental systems. Understanding these differences is important because therapeutic strategies targeting IL-4 and its signaling pathways are currently being tested to treat allergy and asthma.

  15. Numerical analysis of the dynamics of two- and three-dimensional fluidized bed reactors using an Euler–Lagrange approach

    Microsoft Academic Search

    Perrine Pepiot; Olivier Desjardins

    2012-01-01

    Biomass thermochemical conversion, often done in fluidized beds, recently gained a lot of attention due to its potential to efficiently produce renewable liquid fuels. Optimization of reactor design and operating conditions, however, requires a fundamental understanding of bed dynamics. In this work, a numerical framework based on an Euler–Lagrange approach is developed and used to perform and analyze large-scale simulations

  16. Tour of Park Geology: Human Use Sites

    NSDL National Science Digital Library

    This National Park Service (NPS) site provides links to geolgy field notes about National Parks, National Monuments, and National Recreation Areas having to do with geology and human use (such as mining). Information includes geology, photographs, multimedia tools, park maps, visitor information, geologic research, and additional links. Parks covered include Klondike Gold Rush National Historic Park, Alibates Flint Quarries National Monument, and more.

  17. Terrein / car park: Inleveren bij / submit to

    E-print Network

    Galis, Frietson

    Procedure: Terrein / car park: Inleveren bij / submit to: Info: Vul a.u.b. uw gegevens in / please terrein, voor de duur van: Requests access to the car park(s) mentioned above for the period of voorbehoud kan van toepassing zijn. You can request access rights for the local car park(s) on one campus

  18. Parking Details! MARCH BREAK OPEN HOUSE 2014

    E-print Network

    Ellis, Randy

    ! Parking Details! MARCH BREAK OPEN HOUSE 2014 There will be free parking on all Queen's University parking will be available, however please note these options will require payment and are not covered by our free event parking policy. Accessible parking is available upon request, please note this when

  19. IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies, and IL-10 polymorphisms.

    PubMed

    Engelhardt, Karin R; Grimbacher, Bodo

    2014-01-01

    Inflammatory bowel disease (IBD) represents a heterogeneous group of gastrointestinal disorders, where commensal gut flora provokes an either (a) insufficient or (b) uncontrolled immune response. This results either in a lack of or in excessive inflammation mainly manifesting as Crohn's disease or ulcerative colitis. IBD commonly presents in adolescence and adulthood and often follows a chronic relapsing course. Genetic and/or environmental factors contribute to the failure of gut immune homeostasis. Genome-wide association studies have identified over 160 susceptibility loci associated with IBD, including polymorphisms in interleukin-10 (IL-10). The anti-inflammatory cytokine IL-10 dampens intestinal inflammation and is therefore a good candidate gene for IBD. Polymorphisms in the IL-10 receptor are also associated with ulcerative colitis presenting in early childhood. Moreover, severe infantile enterocolitis resembling Crohn's disease, caused by loss-of-function mutations in IL-10 and IL-10 receptor, is characterised by a very early onset (usually within the first 3 months of life), unresponsiveness to standard treatment including immunosuppressive therapy, and severe perianal disease with abscesses and fistulas. In these patients, inflammation and polymorphic infiltrates are mainly confined to the colon with very little involvement of the small intestine. Ulceration and granulomas, bloody diarrhoea and failure to thrive also occur. Furthermore, patients may suffer from recurrent fever and respiratory infections. Individuals with IL-10 receptor mutations also experience cutaneous folliculitis and arthritis. Hematopoietic stem cell transplantation is currently the only curative therapy. PMID:25004811

  20. Augmented Lagrange Hopfield Network for Economic Dispatch with Multiple Fuel Options

    NASA Astrophysics Data System (ADS)

    Dieu, Vo Ngoc; Ongsakul, Weerakorn; Polprasert, Jirawadee

    2011-06-01

    This paper proposes an augmented Lagrange Hopfield network (ALHN) for solving economic dispatch (ED) problem with multiple fuel options. The proposed ALHN method is a continuous Hopfield neural network with its energy function based on augmented Lagrangian function. The advantages of ALHN over the conventional Hopfield neural network are easier use, more general applications, faster convergence, better optimal solution, and larger scale of problem implementation. The method solves the problem by directly searching the most suitable fuel among the available fuels of each unit and finding the optimal solution for the problem based on minimization of the energy function of the continuous Hopfield neural network. The proposed method is tested on systems up to 100 units and the obtained results are compared to those from other methods in the literature. The results have shown that the proposed method is efficient for solving the ED problem with multiple fuel options and favorable for implementation in large scale problems.

  1. On a Lagrange-Hamilton formalism describing position and momentum uncertainties

    NASA Technical Reports Server (NTRS)

    Schuch, Dieter

    1993-01-01

    According to Heisenberg's uncertainty relation, in quantum mechanics it is not possible to determine, simultaneously, exact values for the position and the momentum of a material system. Calculating the mean value of the Hamiltonian operator with the aid of exact analytic Gaussian wave packet solutions, these uncertainties cause an energy contribution additional to the classical energy of the system. For the harmonic oscillator, e.g., this nonclassical energy represents the ground state energy. It will be shown that this additional energy contribution can be considered as a Hamiltonian function, if it is written in appropriate variables. With the help of the usual Lagrange-Hamilton formalism known from classical particle mechanics, but now considering this new Hamiltonian function, it is possible to obtain the equations of motion for position and momentum uncertainties.

  2. The two faces of mimetic Horndeski gravity: disformal transformations and Lagrange multiplier

    E-print Network

    Arroja, Frederico; Karmakar, Purnendu; Matarrese, Sabino

    2015-01-01

    We show that very general scalar-tensor theories of gravity (including, e.g., Horndeski models) are generically invariant under disformal transformations. However there is a special subset, when the transformation is not invertible, that yields new equations of motion which are a generalization of the so-called "mimetic" dark matter theory recently introduced by Chamsedinne and Mukhanov. These new equations of motion can also be derived from an action containing an additional Lagrange multiplier field. The general mimetic scalar-tensor theory has the same number of derivatives in the equations of motion as the original scalar-tensor theory. As an application we show that the simplest mimetic scalar-tensor model is able to mimic the cosmological background of a flat FLRW model with an irrotational barotropic perfect fluid with any constant equation of state.

  3. A suggested trajectory for a Venus-sun, earth-sun Lagrange points mission, Vela

    NASA Technical Reports Server (NTRS)

    Bender, D. F.

    1979-01-01

    The possibility is suggested of investigating the existence of small, as-yet undiscovered, asteroids orbiting in the solar system near the earth-sun or Venus-sun stable Lagrange points by means of a spacecraft which traverses these regions. The type of trajectory suggested lies in the ecliptic plane and has a period of 5/6 years and a perihelion at the Venus orbital distance. The regions in which stable orbits associated with the earth and with Venus may lie are estimated to be a thin and tadpole-shaped area extending from 35 deg to 100 deg from the planet. Crossings of the regions by the trajectory are described, and the requirements for detecting the presence of 1 km sized asteroids are presented and shown to be attainable.

  4. Augmented Lagrange Based on Modified Covariance Matching Criterion Method for DOA Estimation in Compressed Sensing

    PubMed Central

    Si, Weijian; Qu, Xinggen; Liu, Lutao

    2014-01-01

    A novel direction of arrival (DOA) estimation method in compressed sensing (CS) is presented, in which DOA estimation is considered as the joint sparse recovery from multiple measurement vectors (MMV). The proposed method is obtained by minimizing the modified-based covariance matching criterion, which is acquired by adding penalties according to the regularization method. This minimization problem is shown to be a semidefinite program (SDP) and transformed into a constrained quadratic programming problem for reducing computational complexity which can be solved by the augmented Lagrange method. The proposed method can significantly improve the performance especially in the scenarios with low signal to noise ratio (SNR), small number of snapshots, and closely spaced correlated sources. In addition, the Cramér-Rao bound (CRB) of the proposed method is developed and the performance guarantee is given according to a version of the restricted isometry property (RIP). The effectiveness and satisfactory performance of the proposed method are illustrated by simulation results. PMID:24678272

  5. Error estimates of Lagrange interpolation and orthonormal expansions for Freud weights

    NASA Astrophysics Data System (ADS)

    Kwon, K. H.; Lee, D. W.

    2001-08-01

    Let Sn[f] be the nth partial sum of the orthonormal polynomials expansion with respect to a Freud weight. Then we obtain sufficient conditions for the boundedness of Sn[f] and discuss the speed of the convergence of Sn[f] in weighted Lp space. We also find sufficient conditions for the boundedness of the Lagrange interpolation polynomial Ln[f], whose nodal points are the zeros of orthonormal polynomials with respect to a Freud weight. In particular, if W(x)=e-(1/2)x2 is the Hermite weight function, then we obtain sufficient conditions for the inequalities to hold:andwhere and k=0,1,2...,r.

  6. Taylor-Lagrange renormalization scheme: Application to light-front dynamics

    SciTech Connect

    Grange, P.; Mutet, B. [Laboratoire de Physique Theorique et Astroparticules, Universite Montpellier II, CNRS/IN2P3, Place E. Bataillon, F-34095 Montpellier Cedex 05 (France); Mathiot, J.-F. [Clermont Universite, Universite Blaise Pascal, Laboratoire de Physique Corpusculaire, BP 10448, F-63000 Clermont-Ferrand (France); CNRS/IN2P3, UMR6533, LPC, F-63177 Aubiere Cedex (France); Werner, E. [Institut fuer Theoretische Physik, Universitaet Regensburg, Universitaetstrasse 31, D-93053 Regensburg (Germany)

    2009-11-15

    The recently proposed renormalization scheme based on the definition of field operators as operator valued distributions acting on specific test functions is shown to be very convenient in explicit calculations of physical observables within the framework of light-front dynamics. We first recall the main properties of this procedure based on identities relating the test functions to their Taylor remainder of any order expressed in terms of Lagrange's formulas, hence the name given to this scheme. We thus show how it naturally applies to the calculation of state vectors of physical systems in the covariant formulation of light-front dynamics. As an example, we consider the case of the Yukawa model in the simple two-body Fock state truncation.

  7. Consensus of Euler-Lagrange systems networked by sampled-data information with probabilistic time delays.

    PubMed

    Ma, Chao; Shi, Peng; Zhao, Xudong; Zeng, Qingshuang

    2015-06-01

    This paper investigates the consensus problem of multiple Euler-Lagrange systems under directed topology. Unlike the common assumptions on continuous-time information exchanges, a more realistic sampled-data communication strategy is proposed with probabilistic occurrence of time-varying delays. Both of the sampling period and the delays are assumed to be time-varying, which is more general in some practical situations. In addition, the relative coordinate derivative information is not required in the distributed controllers such that the communication network burden can be further reduced. In particular, a distinct feature of the proposed scheme lies in the fact that it can effectively reduce the energy consumption. By employing the stochastic analysis techniques, sufficient conditions are established to guarantee that the consensus can be achieved. Finally, a numerical example is provided to illustrate the applicability and benefits of the theoretical results. PMID:25148678

  8. Testing of Lagrange multiplier damped least-squares control algorithm for woofer-tweeter adaptive optics

    PubMed Central

    Zou, Weiyao; Burns, Stephen A.

    2012-01-01

    A Lagrange multiplier-based damped least-squares control algorithm for woofer-tweeter (W-T) dual deformable-mirror (DM) adaptive optics (AO) is tested with a breadboard system. We show that the algorithm can complementarily command the two DMs to correct wavefront aberrations within a single optimization process: the woofer DM correcting the high-stroke, low-order aberrations, and the tweeter DM correcting the low-stroke, high-order aberrations. The optimal damping factor for a DM is found to be the median of the eigenvalue spectrum of the influence matrix of that DM. Wavefront control accuracy is maximized with the optimized control parameters. For the breadboard system, the residual wavefront error can be controlled to the precision of 0.03 ?m in root mean square. The W-T dual-DM AO has applications in both ophthalmology and astronomy. PMID:22441462

  9. Canyonlands National Park, UT, USA

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Desert and mountain scenery along the Utah/Colorado border are displayed in this scene of the Canyonlands National Park, UT (39.0N, 110.0W). The Park occuppies the near center of the image, displaying spectacular incised meanders and the bulls-eye structure of Upheaval Dome (a salt dome). The Green River and the Colorado River flow southward to join off scene before flowing through the Grand Canyon National Park.

  10. Canyonlands National Park, UT, USA

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Desert and mountain scenery along the Utah/Colorado border are displayed in this scene of the Canyonlands National Park, UT (39.0N, 110.0W). The park occupies the near center of the image, displaying spectacular incised meanders and the bulls-eye structure of Upheaval Dome (a salt dome). The Green River and the Colorado River flow southward to join (off scene) before flowing through the Grand Canyon National Park.

  11. Geology of Badlands National Park

    NSDL National Science Digital Library

    National Park Service (NPS)

    This page is an introduction to the 75 million years of accumulation and intermittent periods of erosion that has resulted in the Badlands National Park. The history of the Oglicene beds of the Park, one of the world's richest vertebrate fossil sites, is also described. A downloadable PDF that describes the erosion that is responsible for the geology of the Park in more detail is linked to the site.

  12. Mesoscale Simulations of Particulate Flows with Parallel Distributed Lagrange Multiplier Technique

    SciTech Connect

    Kanarska, Y

    2010-03-24

    Fluid particulate flows are common phenomena in nature and industry. Modeling of such flows at micro and macro levels as well establishing relationships between these approaches are needed to understand properties of the particulate matter. We propose a computational technique based on the direct numerical simulation of the particulate flows. The numerical method is based on the distributed Lagrange multiplier technique following the ideas of Glowinski et al. (1999). Each particle is explicitly resolved on an Eulerian grid as a separate domain, using solid volume fractions. The fluid equations are solved through the entire computational domain, however, Lagrange multiplier constrains are applied inside the particle domain such that the fluid within any volume associated with a solid particle moves as an incompressible rigid body. Mutual forces for the fluid-particle interactions are internal to the system. Particles interact with the fluid via fluid dynamic equations, resulting in implicit fluid-rigid-body coupling relations that produce realistic fluid flow around the particles (i.e., no-slip boundary conditions). The particle-particle interactions are implemented using explicit force-displacement interactions for frictional inelastic particles similar to the DEM method of Cundall et al. (1979) with some modifications using a volume of an overlapping region as an input to the contact forces. The method is flexible enough to handle arbitrary particle shapes and size distributions. A parallel implementation of the method is based on the SAMRAI (Structured Adaptive Mesh Refinement Application Infrastructure) library, which allows handling of large amounts of rigid particles and enables local grid refinement. Accuracy and convergence of the presented method has been tested against known solutions for a falling sphere as well as by examining fluid flows through stationary particle beds (periodic and cubic packing). To evaluate code performance and validate particle contact physics algorithm, we performed simulations of a representative experiment conducted at the University of California at Berkley for pebble flow through a narrow opening.

  13. Visits to national parks: Effects of park characteristics and spatial demand

    Microsoft Academic Search

    Marjo Neuvonen; Eija Pouta; Jenni Puustinen; Tuija Sievänen

    2010-01-01

    Understanding the relationship between the number of visits to national parks and their characteristics is crucial for park planning and management. Visitation has a key role in existing national parks, but also in assessing the social and economic impacts of new parks. This study examined how the natural characteristics of a park, the recreation facilities and services inside a park

  14. Parking & Security Information UniPark: Phone 6488 1229 and 6488 7184

    E-print Network

    Tobar, Michael

    Centre for Aboriginal Programmes Parking & Security Information UniPark: Phone 6488 1229 and 6488.................................................................. Shuttle Bus Terminus.............................................. T CAR PARKS AND FACILITIES Please read the signs before you park your vehicle! Permit Parking Yellow (student) Car Parks 1, 4, 8, 9, 14, 21, 31, 35

  15. Automated Car Park Management System

    NASA Astrophysics Data System (ADS)

    Fabros, J. P.; Tabańag, D.; Espra, A.; Gerasta, O. J.

    2015-06-01

    This study aims to develop a prototype for an Automated Car Park Management System that will increase the quality of service of parking lots through the integration of a smart system that assists motorist in finding vacant parking lot. The research was based on implementing an operating system and a monitoring system for parking system without the use of manpower. This will include Parking Guidance and Information System concept which will efficiently assist motorists and ensures the safety of the vehicles and the valuables inside the vehicle. For monitoring, Optical Character Recognition was employed to monitor and put into list all the cars entering the parking area. All parking events in this system are visible via MATLAB GUI which contain time-in, time-out, time consumed information and also the lot number where the car parks. To put into reality, this system has a payment method, and it comes via a coin slot operation to control the exit gate. The Automated Car Park Management System was successfully built by utilizing microcontrollers specifically one PIC18f4550 and two PIC16F84s and one PIC16F628A.

  16. Redundant and unique regulation of activated mouse B lymphocytes by IL4 and IL21

    Microsoft Academic Search

    Haoli Jin; Thomas R. Malek

    2006-01-01

    IL-21 distinctively regulates B cell growth and death, and it redundantly functions with IL-4 for IgG production. B cells likely encoun- ter IL-4 and IL-21 in vivo, as both are secreted by activated T cells. Therefore, the action of both these cytokines was investigated during activation of B cells. IL-21 or the combination of IL-4 and IL-21 inhibited proliferation by

  17. Autocrine IL-17A–IL-17RC neutrophil activation in fungal infections is regulated by IL-6, IL-23, ROR?t and Dectin-2

    PubMed Central

    Taylor, Patricia R.; Roy, Sanhita; Leal, Sixto M.; Sun, Yan; Howell, Scott J.; Cobb, Brian A.; Li, Xiaoxia; Pearlman, Eric

    2014-01-01

    Here we identified a population of bone marrow neutrophils that constitutively express ROR?t and which can produce and respond to IL-17A (IL-17). IL-6, IL-23 and ROR?t, but not T cells or NK cells, are required for IL-17 production in neutrophils. IL-6 and IL-23 induced IL-17RC and Dectin-2 expression in neutrophils, and expression of IL-17RC was augmented by Aspergillus and Dectin-2 activation. Autocrine IL-17A–IL-17 receptor activity induced production of reactive oxygen species (ROS), and increased fungal killing in vitro and in a model of Aspergillus keratitis. Human neutrophils also expressed ROR?t, and induced IL-17A, IL-17RC and Dectin-2 expression following IL-6 and IL-23 stimulation. These findings identify a population of human and murine neutrophils that exhibit autocrine IL-17 activity, and which likely contribute to the etiology of microbial and inflammatory diseases. PMID:24362892

  18. Characterization and Favorable in Vivo Properties of Heterodimeric Soluble IL-15·IL-15R? Cytokine Compared to IL-15 Monomer*

    PubMed Central

    Chertova, Elena; Bergamaschi, Cristina; Chertov, Oleg; Sowder, Raymond; Bear, Jenifer; Roser, James D.; Beach, Rachel K.; Lifson, Jeffrey D.; Felber, Barbara K.; Pavlakis, George N.

    2013-01-01

    Interleukin-15 (IL-15), a 114-amino acid cytokine related to IL-2, regulates immune homeostasis and the fate of many lymphocyte subsets. We reported that, in the blood of mice and humans, IL-15 is present as a heterodimer associated with soluble IL-15 receptor ? (sIL-15R?). Here, we show efficient production of this noncovalently linked but stable heterodimer in clonal human HEK293 cells and release of the processed IL-15·sIL-15R? heterodimer in the medium. Purification of the IL-15 and sIL-15R? polypeptides allowed identification of the proteolytic cleavage site of IL-15R? and characterization of multiple glycosylation sites. Administration of the IL-15·sIL-15R? heterodimer reconstituted from purified subunits resulted in sustained plasma IL-15 levels and in robust expansion of NK and T cells in mice, demonstrating pharmacokinetics and in vivo bioactivity superior to single chain IL-15. These identified properties of heterodimeric IL-15 provide a strong rationale for the evaluation of this molecule for clinical applications. PMID:23649624

  19. 49 CFR 397.7 - Parking.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 2014-10-01 2014-10-01 false Parking. 397.7 Section 397.7 Transportation...TRANSPORTATION OF HAZARDOUS MATERIALS; DRIVING AND PARKING RULES General § 397.7 Parking. (a) A motor vehicle which contains...

  20. New Challenges in Campus Parking Management.

    ERIC Educational Resources Information Center

    Mah, Allan

    2000-01-01

    Examines the challenges campus parking professionals face from the increased demands of organizations to improve parking service levels with diminishing resources. Campus parking operations are explored with an awareness of the needs, attitudes, and demands of customers in mind. (GR)

  1. 23 CFR 1235.6 - Parking.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...2010-04-01 2010-04-01 false Parking. 1235.6 Section 1235.6 Highways...TRANSPORTATION GUIDELINES UNIFORM SYSTEM FOR PARKING FOR PERSONS WITH DISABILITIES § 1235.6 Parking. Special license plates,...

  2. 49 CFR 397.7 - Parking.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 2013-10-01 2013-10-01 false Parking. 397.7 Section 397.7 Transportation...TRANSPORTATION OF HAZARDOUS MATERIALS; DRIVING AND PARKING RULES General § 397.7 Parking. (a) A motor vehicle which contains...

  3. 23 CFR 1235.6 - Parking.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...2012-04-01 2012-04-01 false Parking. 1235.6 Section 1235.6 Highways...TRANSPORTATION GUIDELINES UNIFORM SYSTEM FOR PARKING FOR PERSONS WITH DISABILITIES § 1235.6 Parking. Special license plates,...

  4. OSU PARKING UTILIZATION FALL TERM 2008

    E-print Network

    Escher, Christine

    OSU PARKING UTILIZATION STUDY FALL TERM 2008 FACILITIES SERVICES CAMPUS PLANNING #12;Facilities Services- Campus Planning March, 2009 2008 OSU PARKING UTILIZATION STUDY Table of Contents Purpose.....................................................................................................3 OSU Main Campus Parking Survey

  5. 23 CFR 1235.6 - Parking.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...2011-04-01 2011-04-01 false Parking. 1235.6 Section 1235.6 Highways...TRANSPORTATION GUIDELINES UNIFORM SYSTEM FOR PARKING FOR PERSONS WITH DISABILITIES § 1235.6 Parking. Special license plates,...

  6. 23 CFR 1235.6 - Parking.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...2014-04-01 2014-04-01 false Parking. 1235.6 Section 1235.6 Highways...TRANSPORTATION GUIDELINES UNIFORM SYSTEM FOR PARKING FOR PERSONS WITH DISABILITIES § 1235.6 Parking. Special license plates,...

  7. 23 CFR 1235.6 - Parking.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...2013-04-01 2013-04-01 false Parking. 1235.6 Section 1235.6 Highways...TRANSPORTATION GUIDELINES UNIFORM SYSTEM FOR PARKING FOR PERSONS WITH DISABILITIES § 1235.6 Parking. Special license plates,...

  8. 49 CFR 397.7 - Parking.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 2012-10-01 2012-10-01 false Parking. 397.7 Section 397.7 Transportation...TRANSPORTATION OF HAZARDOUS MATERIALS; DRIVING AND PARKING RULES General § 397.7 Parking. (a) A motor vehicle which contains...

  9. Modulation effect of Semen Ziziphi Spinosae extracts on IL-1?, IL-4, IL-6, IL-10, TNF-? and IFN-? in mouse serum.

    PubMed

    Xie, Junbo; Guo, Li; Pang, Guangchang; Wu, Xin; Zhang, Mingchun

    2011-02-01

    This study aims to explore and evaluate the effects of Semen Ziziphi Spinosae extracts on the serum levels of interleukin (IL)-6, IFN-?, IL-1?, TNF-?, IL-10 and IL-4 in mice, and the regulative effect of Semen Ziziphi Spinosae on the cytokine system. Using an ELISA assay, the serum levels of IL-6, IFN-?, IL-1?, TNF-?, IL-10 and IL-4 were examined in mice after intraperitoneal injection (i.p.) with Semen Ziziphi Spinosae extracts. The results showed that the levels of IL-6 and IL-1? were significantly increased compared with the control groups (p<0.01), while the level of tumour necrosis factor-? (TNF-?) was significantly decreased (p<0.01). Semen Ziziphi Spinosae possesses certain modulation effects on cytokines, and the immuno-regulating function and hypnosis effects of Semen Ziziphi Spinosae may be relevant to these modulation effects on cytokines. PMID:21328141

  10. Geology Fieldnotes: Petrified Forest National Park, Arizona

    NSDL National Science Digital Library

    Petrified Forest National Park was established to preserve large deposits of petrified wood and to prevent removal of the wood by the public. Site featues include park geology information, maps, photographs, related links, visitor information, multimedia resources, and resources for teaching geology with National Park examples. The park geology section discusses the park's geologic history, structural geology, petrified wood, and dinosaur fossils. The maps section includes a map of the park itself and the surrounding area.

  11. National Park Service: Nature and Science

    NSDL National Science Digital Library

    This is the nature and science portal for the National Park Service. Visitors can access information on air quality in the national parks, wildlife health and management, invasive species, threatened and endangered species, and others. Geologic materials include park geology tours, minerals management in and adjacent to parks, disturbed lands restoration, and others. Water-related materials include wetlands in parks, fisheries, water quality and flow issues, and others. Additional materials include park soundscapes, laws and regulations, publications, and news articles.

  12. Microbiology in Yellowstone National Park

    NSDL National Science Digital Library

    Ward David

    This site describes how Yellowstone National Park is a focal point for cutting-edge microbiology research and how it provides a valuable setting for outreach education. Topics include questions for park officials, extremophiles, microbe diversity and evolution, educational outreach, and suggested reading.

  13. California Community Colleges Parking Survey.

    ERIC Educational Resources Information Center

    McIntyre, Chuck

    In 1990, a representative sample of 25 California community colleges was contacted by telephone to determine their parking policies and practices. The colleges were sampled on the basis of location and size. Study findings included the following: (1) 17 of the colleges reported that they had insufficient numbers of on-campus parking spaces; (2)…

  14. Cardinal Soccer Clinic Peckham Park

    E-print Network

    Devoto, Stephen H.

    Cardinal Soccer Clinic at Peckham Park Middlefield, CT Dates: July 25-29, 2011 Time: 6:00-8:00 pm Who: Boys and Girls ­ Ages 5-12 (Grades K-6) Coaches: Geoff Wheeler ­ Wesleyan Men's Soccer Coach Why: Come enjoy a great week of soccer focused on individual skills, teamwork and fun! Where: Peckham Park

  15. Evaluation of IL17A expression and of IL17A, IL17F and IL23R gene polymorphisms in Brazilian individuals with periodontitis.

    PubMed

    Saraiva, Adriana Machado; Alves e Silva, Micena Roberta Miranda; Correia Silva, Jeane de Fátima; da Costa, José Eustáquio; Gollob, Kenneth John; Dutra, Walderez Ornelas; Moreira, Paula Rocha

    2013-02-01

    The IL23/Th17 axis plays an important role in the pathogenesis of cell-mediated tissue damage caused either by autoimmunity or immune responses against bacterial infection. Single nucleotide polymorphisms in the IL17A, IL17F and IL23R genes have been associated with several inflammatory diseases. However, these polymorphisms have not yet been studied in periodontitis. The aim of present study was to evaluate the expression of IL17A and occurrence of the IL17A (rs2275913), IL17F (rs763780) and IL23R (rs11209026) gene polymorphisms in different clinical forms or severity of periodontitis in a sample of Brazilian individuals. Peripheral blood was obtained from 30 non-smoker individuals and analyzed by flow cytometry to determine IL-17 expression. Genomic DNA was obtained from oral swabs in 180 individuals and analyzed by Real-time PCR. The study group was composed by individuals without periodontitis (control), with aggressive periodontitis (AP) and with chronic periodontitis (CP). Higher frequency of IL17A+CD4+ T cells was observed in control group. The A+ genotype from IL17A (rs2275913) was associated with lack of disease. No association was found considering the IL17F and IL23R polymorphisms. Our data suggest that IL17A and the presence of IL17A (rs2275913) A allele are associated with the absence of periodontal disease. PMID:23137879

  16. IL-3 synergises with basophil-derived IL-4 and IL-13 to promote the alternative activation of human monocytes.

    PubMed

    Borriello, Francesco; Longo, Michele; Spinelli, Rosa; Pecoraro, Antonio; Granata, Francescopaolo; Staiano, Rosaria Ilaria; Loffredo, Stefania; Spadaro, Giuseppe; Beguinot, Francesco; Schroeder, John; Marone, Gianni

    2015-07-01

    Basophil-derived IL-4 is involved in the alternative activation of mouse monocytes, as recently shown in vivo. Whether this applies to human basophils and monocytes has not been established yet. Here, we sought to characterise the interaction between basophils and monocytes and identify the molecular determinants. A basophil-monocyte co-culture model revealed that IL-3 and basophil-derived IL-4 and IL-13 induced monocyte production of CCL17, a marker of alternative activation. Critically, IL-3 and IL-4 acted directly on monocytes to induce CCL17 production through histone H3 acetylation, but did not increase the recruitment of STAT5 or STAT6. Although freshly isolated monocytes did not express the IL-3 receptor ? chain (CD123), and did not respond to IL-3 (as assessed by STAT5 phosphorylation), the overnight incubation with IL-4 (especially if associated with IL-3) upregulated CD123 expression. IL-3-activated JAK2-STAT5 pathway inhibitors reduced the CCL17 production in response to IL-3 and IL-4, but not to IL-4 alone. Interestingly, monocytes isolated from allergen-sensitised asthmatic patients exhibited a higher expression of CD123. Taken together, our data show that the JAK2-STAT5 pathway modulates both basophil and monocyte effector responses. The coordinated activation of STAT5 and STAT6 may have a major impact on monocyte alternative activation in vitro and in vivo. PMID:25824485

  17. IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling.

    PubMed

    Hoge, Judith; Yan, Isabell; Jänner, Nathalie; Schumacher, Valéa; Chalaris, Athena; Steinmetz, Oliver M; Engel, Daniel R; Scheller, Jürgen; Rose-John, Stefan; Mittrücker, Hans-Willi

    2013-01-15

    The cytokine IL-6 plays a protective role in immune responses against bacterial infections. However, the mechanisms of IL-6-mediated protection are only partially understood. IL-6 can signal via the IL-6R complex composed of membrane-bound IL-6R? (mIL-6R?) and gp130. Owing to the restricted expression of mIL-6R?, classical IL-6 signaling occurs only in a limited number of cells such as hepatocytes and certain leukocyte subsets. IL-6 also interacts with soluble IL-6R? proteins and these IL-6/soluble IL-6R? complexes can subsequently bind to membrane-bound gp130 proteins and induce signaling. Because gp130 is ubiquitously expressed, this IL-6 trans-signaling substantially increases the spectrum of cells responding to IL-6. In this study, we analyze the role of classical IL-6 signaling and IL-6 trans-signaling in the innate immune response of mice against Listeria monocytogenes infection. We demonstrate that L. monocytogenes infection causes profound systemic IL-6 production and rapid loss of IL-6R? surface expression on neutrophils, inflammatory monocytes, and different lymphocyte subsets. IL-6-deficient mice or mice treated with neutralizing anti-IL-6 mAb displayed impaired control of L. monocytogenes infection accompanied by alterations in the expression of inflammatory cytokines and chemokines, as well as in the recruitment of inflammatory cells. In contrast, restricted blockade of IL-6 trans-signaling by application or transgenic expression of a soluble gp130 protein did not restrain the control of infection. In summary, our results demonstrate that IL-6R? surface expression is highly dynamic during the innate response against L. monocytogenes and that the protective IL-6 function is dependent on classical IL-6 signaling via mIL-6R?. PMID:23241882

  18. Cytokine interactions in human immunodeficiency virus-infected individuals: roles of interleukin (IL)-2, IL-12, and IL-15

    PubMed Central

    1995-01-01

    Cytokines have been shown to be powerful regulators of the immune response. In this study, we analyze the effect that the newly recognized cytokine interleukin (IL)-15 has on proliferation and cytokine induction using peripheral blood mononuclear cells (PBMCs) and purified CD4+ T cells from patients infected with human immunodeficiency virus (HIV) who are at various stages in their disease. We observed that IL-15 enhances the proliferative response in a dose-dependent manner from PBMCs of HIV-infected individuals when stimulated by polyclonal mitogen, tetanus toxoid, or HIV-specific antigen. The effects of exogenous IL-15 are substantially diminished by adding a neutralizing antibody to the beta chain of the IL-2 receptor. Moreover, the ability of IL-15 to increase proliferation is enhanced by the presence of endogenous IL-2 produced in the cultures. The effect that exogenous IL-15 had on IL-2, IL-4, and interferon (IFN)-gamma induction from PBMC's or CD4+ T cells in response to mitogen or tetanus toxoid was also examined. This was compared to the effect that exogenous IL-2 and IL-12 had under the same conditions. Addition of IL- 2 or IL-15 to short-term in vitro cultures of either PBMCs or CD4+ T cells had little effect on IL-2, IL-4, or IFN-gamma production. By contrast, IL-12 caused substantial enhancement of both IL-2 and IFN- gamma production from these cultures. The role that endogenous cytokines have on IFN-gamma induction was also studied. Addition of a neutralizing antibody to the alpha chain of the IL-2 receptor or IL-12 to antigen stimulated cultures caused a striking decrease in IFN-gamma production. Neutralization of endogenous IL-15 also resulted in diminished IFN-gamma production from cultures stimulated with mitogen. IL-4 and IFN-gamma protein production by PBMCs and CD4+ T cells stimulated with mitogen was assessed to see if we could detect a specific bias of cytokine production. Small amounts of IL-4 were detected from CD4+ T cells but not PBMCs from most individuals tested. IFN-gamma and IL-2, however, were also produced from these same cultures. These results further elucidate the mechanism of cytokine regulation in HIV-infected individuals, and they provide evidence that IL-15 may be a useful immune modulator. PMID:7561680

  19. Jagged-1 signaling suppresses the IL-6 and TGF-? treatment-induced Th17 cell differentiation via the reduction of ROR?t/IL-17A/IL-17F/IL-23a/IL-12rb1

    PubMed Central

    Wang, Yuan; Xing, Feiyue; Ye, Siqi; Xiao, Jia; Di, Jingfang; Zeng, Shan; Liu, Jing

    2015-01-01

    Jagged-1 signaling has recently been reported to be involved in the Th17 cell differentiation. However, little is known about its mechanisms. Soluble Jagged-1 was used to activate the Jagged-1–Notch signaling to interfere with the IL-6 and TGF-?-induced Th17 cell skewing. Genes relevant to the autoimmunity or inflammation were screened for the first time in this system by qPCR array for the differential expressions. The 18 genes out of 84, including Clec7a, Il12b, Il12rb1, Il12rb2, Csf3, Il15, Il17a, Il17f, Il17rc, Il17rd, Il17re, Il23a, Myd88, Socs1, Stat4, Stat5a, Sykb and Tbx21, were downregulated, but only Cxcl2, Cxcl12 and Mmp3 were upregulated. The expressions of the genes, Ror?t, Il17a, Il17f, Il12rb1 and Il23a, induced by simultaneous IL-6 and TGF-? treatment were significantly suppressed by Jagged-1, followed by the reduction of ROR?t, IL-17A, and IL-17F. Consistent with the attenuation of ROR?t, and the reduced production and secretion of IL-17A and IL-17F in the cell supernatant and the in situ stained cells, the number of CD4+IL-17+ cells was also diminished. It is concluded that the Jagged-1–Notch signaling can suppress the IL-6 and TGF-? treatment-induced Th17 cell skewing through the attenuation of ROR?t and, hence by, the down-regulation of IL-17A, IL-17F, IL-23a, and IL-12rb1. PMID:25648768

  20. PARKiNG iNfoRmAtioN CAMPUS PARkING LOTS and ARRANGEMENTS ______________________________________

    E-print Network

    Hemmers, Oliver

    Parking Garage for visits of less than 2 hours. For visits of more than 2 hours, UNLV· daily and weekly and the Parking Garage on the extreme northeast end of the campus.Travel south on Maryland Parkway; take Avenue can also be accessed by turning right from eastbound Flamingo Road at the Claymont Avenue traffic

  1. Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex

    SciTech Connect

    Kennedy, M.K.; Park, L.S. [Immunex Corp., Seattle, WA (United States)

    1996-05-01

    IL-15 interacts with a heterotrimeric receptor that consists of the {beta} and {gamma} subunits of the IL-2 receptor (IL-2R) as well as a specific, high-affinity IL-15-binding subunit, which is designated IL-15R{alpha}. Since both the {beta} and the {gamma} subunits of the IL-2R are required for signaling by either IL-2 or IL-15, it is not surprising that these cytokines share many activities in vitro. However, the differential expression of these cytokines and the {alpha} chains of their receptors within various tissues and cell types suggests that IL-2 and IL-15 may perform at least partially distinct physiological functions. The production of IL-15 by macrophages, and possibly other cell types, in response to environmental stimuli and infectious agents suggests that IL-15 may play a role in protective immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. 56 refs.

  2. Quantitative analysis of IL-2 and IL-15 signal transduction in T lymphocytes

    E-print Network

    Arneja, Abhinav

    2013-01-01

    IL-2 and IL-15 are common y-chain family cytokines critically involved in regulation of T cell differentiation and homeostasis. Both cytokines signal through a heterotrimeric surface receptor complex (IL-2/15R) composed ...

  3. The regulation of IL-10 expression.

    PubMed

    Gabryšová, Leona; Howes, Ashleigh; Saraiva, Margarida; O'Garra, Anne

    2014-01-01

    Interleukin (IL)-10 is an important immunoregulatory cytokine and an understanding of how IL-10 expression is controlled is critical in the design of immune intervention strategies. IL-10 is produced by almost all cell types within the innate (including macrophages, monocytes, dendritic cells (DCs), mast cells, neutrophils, eosinophils and natural killer cells) and adaptive (including CD4(+) T cells, CD8(+) T cells and B cells) immune systems. The mechanisms of IL-10 regulation operate at several stages including chromatin remodelling at the Il10 locus, transcriptional regulation of Il10 expression and post-transcriptional regulation of Il10 mRNA. In addition, whereas some aspects of Il10 gene regulation are conserved between different immune cell types, several are cell type- or stimulus-specific. Here, we outline the complexity of IL-10 production by discussing what is known about its regulation in macrophages, monocytes, DCs and CD4(+) T helper cells. PMID:25004818

  4. PARK2 Mediates Interleukin 6 and Monocyte Chemoattractant Protein 1 Production by Human Macrophages

    PubMed Central

    de Léséleuc, Louis; Girard, Manon; Huong, Nguyen Thu; Ba, Nguyen Ngoc; Van Thuc, Nguyen; Truman, Richard; Spencer, John S.; Adams, Linda; Thai, Vu Hong; Alcais, Alexandre; Schurr, Erwin

    2013-01-01

    Leprosy is a persistent infectious disease caused by Mycobacterium leprae that still affects over 200,000 new patients annually. The host genetic background is an important risk factor for leprosy susceptibility and the PARK2 gene is a replicated leprosy susceptibility candidate gene. The protein product of PARK2, Parkin, is an E3 ubiquitin ligase that is involved in the development of various forms of Parkinsonism. The human macrophage is both a natural host cell of M. leprae as well as a primary mediator of natural immune defenses, in part by secreting important pro-inflammatory cytokines and chemokines. Here, we report that down-regulation of Parkin in THP-1 macrophages, human monocyte-derived macrophages and human Schwann cells resulted in a consistent and specific decrease in interleukin-6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1/CCL2) production in response to mycobacteria or LPS. Interestingly, production of IL-6 at 6 hours by THP-1 cells stimulated with live M. leprae and M. bovis BCG was dependent on pretreatment with 1,25-dihydroxyvitamin D3 (VD). Parkin knockdown in VD-treated cells blocked IL-6 induction by mycobacteria. However, I?B-? phosphorylation and levels of I?B-?, a nuclear protein required for IL-6 expression, were not affected by Parkin silencing. Phosphorylation of MAPK ERK1/2 and p38 was unaffected by Parkin silencing while JNK activation was promoted but did not explain the altered cytokine production. In a final set of experiments we found that genetic risk factors of leprosy located in the PARK2 promoter region were significantly correlated with M. leprae sonicate triggered CCL2 and IL6 transcript levels in whole blood assays. These results associated genetically controlled changes in the production of MCP-1/CCL2 and IL-6 with known leprosy susceptibility factors. PMID:23350010

  5. Identification of IFN-?-Producing Cells in IL12\\/IL18Treated Mice

    Microsoft Academic Search

    Takeshi Otani; Shuji Nakamura; Miwako Toki; Ryuichi Motoda; Masashi Kurimoto; Kunzo Orita

    1999-01-01

    Both IL-12 and IL-18 have been characterized as effective IFN-?-inducing cytokines. Concomitant treatment with IL-12 and IL-18 has been shown to synergistically induce IFN-? and may be an effective therapy for treating cancer, allergy, and infectious diseases. To understand the mechanisms underlying the strong induction of IFN-? by IL-12\\/IL-18 in mice, we focused our studies on the IFN-?-producing cells in

  6. Procedure for Citation Payment at Parking Online 1. Go to Parking Services webpage at http://www.uaf.edu/parking.

    E-print Network

    Ickert-Bond, Steffi

    Procedure for Citation Payment at Parking Online 1. Go to Parking Services webpage at http://www.uaf.edu/parking. 2. Select Citation Payment under the Parking Online Logo. 3. Select Citation Payment from the Menu. 4. Enter the citation number (a letter followed by seven digit number, ex. A0000000) 5. Enter

  7. Procedure for Citation Appeal at Parking Online 1. Go to Parking Services webpage at http://www.uaf.edu/parking.

    E-print Network

    Ickert-Bond, Steffi

    Procedure for Citation Appeal at Parking Online 1. Go to Parking Services webpage at http://www.uaf.edu/parking. 2. Select Appeal Citation under the Parking Online Logo. 3. Select Appeal Citation from the Menu. 4 the citation number (a letter followed by seven digit number, ex. A0000000) 6. Enter the vehicle plate

  8. Amusement Park Physics

    NSDL National Science Digital Library

    It's one thing to learn about physics in a lab, but it can be quite another thing to make a pilgrimage to an amusement park to take in the laws of physics. Users will have to supply their own corn dogs and popcorn, but this rather nice educational resource from Annenberg Media will be quite useful for budding physicists and their teachers. The resource allows users to design their own roller coaster, and along the way they will learn a thing or two about the laws of gravity, pendulums, and kinetic energy. Along with explanatory essays, this resource contains interactive graphics and a glossary of terms. Sit back and enjoy the virtual roller coaster ride, as this site provides a rather novel way of introducing students to physics.

  9. Aftermath of Griffith Park Fire

    NASA Technical Reports Server (NTRS)

    2007-01-01

    In mid-May 2007, wind-driven flames raced through Griffith Park in Los Angeles, forcing hasty evacuations and threatening numerous famous landmarks and tourist spots, such as the Los Angeles Zoo and the Hollywood Sign. Ultimately, no one was injured in the fire, which may have been started by a cigarette. About 800 acres burned in the urban park, which is itself a Hollywood landmark, having been the location for several movies, including Rebel Without A Cause. This image of the park was captured by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite on June 6, 2007, about a month after the fire. ASTER detects both visible and infrared wavelengths of light, and both kinds have been used to make this image. Vegetation appears in various shades of red, while the burned areas appear charcoal. Roads and dense urban areas appear purplish-gray or white. Water is dark blue. Large burned areas are evident in the northwest and southeast parts of the park, with scattered smaller patches along the southern margin. Some botanical gardens and parts of a bird sanctuary, as well as some park structures like restrooms, were destroyed. The park's unburned, natural vegetation appears brick red, while the irrigated golf courses adjacent to the park are bright red. NASA image created by Jesse Allen, using data provided courtesy of the NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.

  10. A Lagrange-multiplier-based XFEM to solve pressure Poisson equations in problems with quasi-static interfaces

    NASA Astrophysics Data System (ADS)

    Liao, JianHui; Zhuang, Zhuo

    2012-04-01

    The XFEM (extended finite element method) has a lot of advantages over other numerical methods to resolve discontinuities across quasi-static interfaces due to the jump in fluidic parameters or surface tension. However, singularities corresponding to enriched degrees of freedom (DOFs) embedded in XFEM arise in the discrete pressure Poisson equations. In this paper, constraints on these DOFs are derived from the interfacial equilibrium condition and introduced in terms of stabilized Lagrange multipliers designed for non-boundary-fitted meshes to address this issue. Numerical results show that the weak and strong discontinuities in pressure with straight and circular interfaces are accurately reproduced by the constraints. Comparisons with the SUPG/PSPG (streamline upwind/pressure stabilizing Petrov-Galerkin) method without Lagrange multipliers validate the applicability and flexibility of the proposed constrained algorithm to model problems with quasi-static interfaces.

  11. Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense.

    PubMed

    McAleer, Jeremy P; Kolls, Jay K

    2014-07-01

    Respiratory infections and diseases are among the leading causes of death worldwide, and effective treatments probably require manipulating the inflammatory response to pathogenic microbes or allergens. Here, we review mechanisms controlling the production and functions of interleukin-17 (IL-17) and IL-22, cytokines that direct several aspects of lung immunity. Innate lymphocytes (?? T cells, natural killer cells, innate lymphoid cells) are the major source of IL-17 and IL-22 during acute infections, while CD4(+) T-helper 17 (Th17) cells contribute to vaccine-induced immunity. The characterization of dendritic cell (DC) subsets has revealed their central roles in T-cell activation. CD11b(+) DCs stimulated with bacteria or fungi secrete IL-1? and IL-23, potent inducers of IL-17 and IL-22. On the other hand, recognition of viruses by plasmacytoid DCs inhibits IL-1? and IL-23 release, increasing susceptibility to bacterial superinfections. IL-17 and IL-22 primarily act on the lung epithelium, inducing antimicrobial proteins and neutrophil chemoattractants. Recent studies found that stimulation of macrophages and DCs with IL-17 also contributes to antibacterial immunity, while IL-22 promotes epithelial proliferation and repair following injury. Chronic diseases such as asthma and chronic obstructive pulmonary disease have been associated with IL-17 and IL-22 responses directed against innocuous antigens. Future studies will evaluate the therapeutic efficacy of targeting the IL-17/IL-22 pathway in pulmonary inflammation. PMID:24942687

  12. Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense

    PubMed Central

    McAleer, Jeremy P.; Kolls, Jay K.

    2014-01-01

    Summary Respiratory infections and diseases are among the leading causes of death worldwide, and effective treatments likely require manipulating the inflammatory response to pathogenic microbes or allergens. Here we review mechanisms controlling the production and functions of interleukin-17 (IL-17) and IL-22, cytokines that direct several aspects of lung immunity. Innate lymphocytes (??T cells, natural killer cells, innate lymphoid cells) are the major source of IL-17 and IL-22 during acute infections, while CD4+ T-helper 17 (Th17) cells contribute to vaccine-induced immunity. The characterization of dendritic cell (DC) subsets has revealed their central roles in T-cell activation. CD11b+ DCs stimulated with bacteria or fungi secrete IL-1? and IL-23, potent inducers of IL-17 and IL-22. On the other hand, recognition of viruses by plasmacytoid DCs inhibits IL-1? and IL-23 release, increasing susceptibility to bacterial superinfections. IL-17 and IL-22 primarily act on the lung epithelium, inducing antimicrobial proteins and neutrophil chemoattractants. Recent studies found that stimulation of macrophages and DCs with IL-17 also contributes to anti-bacterial immunity, while IL-22 promotes epithelial proliferation and repair following injury. Chronic diseases such as asthma and chronic obstructive pulmonary disease have been associated with IL-17 and IL-22 responses directed against innocuous antigens. Future studies will evaluate the therapeutic efficacy of targeting the IL-17/IL-22 pathway in pulmonary inflammation. PMID:24942687

  13. Untangling the Complex Web of IL-4- and IL-13-Mediated Signaling Pathways

    NSDL National Science Digital Library

    Marsha Wills-Karp (Cincinnati Children's Hospital Medical Center; Division of Immunobiology REV)

    2008-12-23

    Unraveling the exact signaling events mediating the distinct functions of the T cell–derived cytokines interleukin-4 (IL-4) and IL-13 has been challenging because they are structurally similar and share a functional signaling receptor chain. A study now proposes a potential molecular mechanism to explain the functional differences between IL-4 and IL-13 that involves the ability of IL-4, but not IL-13, to effectively activate the insulin receptor substrate–2 (IRS-2) signaling cascade through binding to its receptor. A better understanding of the interactions of IL-4 and IL-13 with their cognate receptors may facilitate the development of therapies without unintended side effects.

  14. Recombinant p35 from Bacteria Can Form Interleukin (IL-)12, but Not IL-35

    PubMed Central

    Aparicio-Siegmund, Samadhi; Moll, Jens M.; Lokau, Juliane; Grusdat, Melanie; Schröder, Jutta; Plöhn, Svenja; Rose-John, Stefan; Grötzinger, Joachim; Lang, Philipp A.; Scheller, Jürgen; Garbers, Christoph

    2014-01-01

    The Interleukin (IL)-12 family contains several heterodimeric composite cytokines which share subunits among each other. IL-12 consists of the subunits p40 (shared with IL-23) and p35. p35 is shared with the composite cytokine IL-35 which comprises of the p35/EBI3 heterodimer (EBI3 shared with IL-27). IL-35 signals via homo- or heterodimers of IL-12R?2, gp130 and WSX-1, which are shared with IL-12 and IL-27 receptor complexes, respectively. p35 was efficiently secreted in complex with p40 as IL-12 but not with EBI3 as IL-35 in several transfected cell lines tested which complicates the analysis of IL-35 signal transduction. p35 and p40 but not p35 and EBI3 form an inter-chain disulfide bridge. Mutation of the responsible cysteine residue (p40C197A) reduced IL-12 formation and activity only slightly. Importantly, the p40C197A mutation prevented the formation of antagonistic p40 homodimers which enabled the in vitro reconstitution of biologically active IL-12 with p35 produced in bacteria (p35bac). Reconstitution of IL-35 with p35bac and EBI3 did, however, fail to induce signal transduction in Ba/F3 cells expressing IL-12R?2 and gp130. In summary, we describe the in vitro reconstitution of IL-12, but fail to produce recombinant IL-35 by this novel approach. PMID:25259790

  15. Park and chill : redesign parking garage in Hong Kong

    E-print Network

    Ting, Sze Ngai

    2011-01-01

    What are the aesthetics of urban infrastructure? Urban infrastructure has remained isolated to human activities. We all share memory and experience with urban infrastructure, e.g. we drive on the same roads and park our ...

  16. 1.OA At the Park

    NSDL National Science Digital Library

    This is a task from the Illustrative Mathematics website that is one part of a complete illustration of the standard to which it is aligned. Each task has at least one solution and some commentary that addresses important asects of the task and its potential use. Here are the first few lines of the commentary for this task: There were 7 children at the park. Then 4 more showed up. How many children were at the park all together? There were 7 children at the park. Some more...

  17. Implementation of the Euler-Lagrange and poisson equations to extract one connected region

    NASA Astrophysics Data System (ADS)

    Bowden, A.; Todorov, M. D.; Sirakov, N. M.

    2014-11-01

    This paper presents a numerical method that evolves an active contour toward the boundary of one connected image region. The numerical method implements a model which uses the solution of the Euler-Lagrange Differential Equation in order to minimize a "snake" functional. This functional is constructed as an integral of the so called internal and external energies. The internal energy is related to the moving contour. The external energy represents the image. The minimum of the functional falls on the boundaries of objects placed in the image. A half step numerical scheme implements the concepts. The contributions of the new model come from the use of the solution of the Poisson equation and development of a new penalty function to halt the contour on the object's boundary. In order to make the contour move across homogeneous regions and enlarge the capture range, we solve the Poisson equation with Dirichlet boundary conditions and generate a gradient vector field of the image. The numerical method is implemented with MatLab and uses a stop condition based on the gradient. The advantages of the model are that it has a large capture range, is accurate in detecting the boundaries of image objects, and is capable of surpassing noise. A disadvantage is that the user has to select the right values of three parameters. Several experiments with synthetic, weapon, and medical images have been conducted to validate the model. Our work continues with the goal of cutting the curve in the event multiple objects have been enveloped.

  18. Inverse Analysis of North American Methane Emissions Using the CarbonTracker-Lagrange Modeling Framework

    NASA Astrophysics Data System (ADS)

    Benmergui, J. S.; Andrews, A. E.; Thoning, K. W.; Trudeau, M.; Michalak, A. M.; Yadav, V.; Miller, S. M.; Dlugokencky, E. J.; Bruhwiler, L.; Masarie, K. A.; Worthy, D. E. J.; Sweeney, C.; Fischer, M. L.; Nehrkorn, T.; Mountain, M. E.; Wofsy, S. C.

    2014-12-01

    Several recent studies have attempted to quantify methane (CH4) emissions in North America, but large uncertainties remain in the magnitude, spatial and temporal distribution, and source sectors responsible. Estimates of biogenic emissions from wetlands, emissions related to animal husbandry, and the continental scale implications of recent shifts in the oil and gas industry are poorly constrained. We estimate North American CH4 emissions from biogenic and anthropogenic sources using the new CarbonTracker-Lagrange inverse modeling framework. A wide array of measurements taken between 2007 and 2012 provide top-down constraints. These include: in-situ and flask measurements made at surface sites, tall towers, and aboard aircraft; and remote sensing observations. Source region sensitivity is provided by the Stochastic Time-Inverted Lagrangian Transport (STILT) model, driven by meteorological fields from the Weather Research and Forecasting (WRF) model. CH4 emissions and background values are optimized simultaneously through Bayesian and geostatistical inversion. A restricted maximum likelihood estimation procedure is used to derive uncertainties in both emissions and the mole fraction field. The wide temporal coverage, dense network of measurements, and varied sources of data allow for an analysis of spatio-temporal trends in emissions that has not previously been accomplished with top-down constraints.

  19. Predicting the safe load on backpacker's arm using Lagrange multipliers method

    NASA Astrophysics Data System (ADS)

    Abdalla, Faisal Saleh; Rambely, Azmin Sham

    2014-09-01

    In this study, a technique has been suggested to reduce a backpack load by transmitting determined loads to the children arm. The purpose of this paper is to estimate school children arm muscles while load carriage as well as to determine the safe load can be carried at wrist while walking with backpack. A mathematical model, as three DOFs model, was investigated in the sagittal plane and Lagrange multipliers method (LMM) was utilized to minimize a quadratic objective function of muscle forces. The muscle forces were minimized with three different load conditions which are termed as 0-L=0 N, 1-L=21.95 N, and 2-L=43.9 N. The investigated muscles were estimated and compared to their maximum forces throughout the load conditions. Flexor and extensor muscles were estimated and the results showed that flexor muscles were active while extensor muscles showed inactivity. The estimated muscle forces were didn't exceed their maximum forces with 0-L and 1-L conditions whereas biceps and FCR muscles exceeded their maximum forces with 2-L condition. Consequently, 1-L condition is quiet safe to be carried by hand whereas 2-L condition is not. Thus to reduce the load in the backpack the transmitted load shouldn't exceed 1-L condition.

  20. Uncertainties of predictions from parton distribution functions. I. The Lagrange multiplier method

    NASA Astrophysics Data System (ADS)

    Stump, D.; Pumplin, J.; Brock, R.; Casey, D.; Huston, J.; Kalk, J.; Lai, H. L.; Tung, W. K.

    2002-01-01

    We apply the Lagrange multiplier method to study the uncertainties of physical predictions due to the uncertainties of parton distribution functions (PDF's), using the cross section ?W for W production at a hadron collider as an archetypal example. An effective ?2 function based on the CTEQ global QCD analysis is used to generate a series of PDF's, each of which represents the best fit to the global data for some specified value of ?W. By analyzing the likelihood of these ``alterative hypotheses,'' using available information on errors from the individual experiments, we estimate that the fractional uncertainty of ?W due to current experimental input to the PDF analysis is approximately +/-4% at the Fermilab Tevatron, and +/-8-10% at the CERN Large Hadron Collider. We give sets of PDF's corresponding to these up and down variations of ?W. We also present similar results on Z production at the colliders. Our method can be applied to any combination of physical variables in precision QCD phenomenology, and it can be used to generate benchmarks for testing the accuracy of approximate methods based on the error matrix.

  1. An Euler-Lagrange method considering bubble radial dynamics for modeling sonochemical reactors.

    PubMed

    Jamshidi, Rashid; Brenner, Gunther

    2014-01-01

    Unsteady numerical computations are performed to investigate the flow field, wave propagation and the structure of bubbles in sonochemical reactors. The turbulent flow field is simulated using a two-equation Reynolds-Averaged Navier-Stokes (RANS) model. The distribution of the acoustic pressure is solved based on the Helmholtz equation using a finite volume method (FVM). The radial dynamics of a single bubble are considered by applying the Keller-Miksis equation to consider the compressibility of the liquid to the first order of acoustical Mach number. To investigate the structure of bubbles, a one-way coupling Euler-Lagrange approach is used to simulate the bulk medium and the bubbles as the dispersed phase. Drag, gravity, buoyancy, added mass, volume change and first Bjerknes forces are considered and their orders of magnitude are compared. To verify the implemented numerical algorithms, results for one- and two-dimensional simplified test cases are compared with analytical solutions. The results show good agreement with experimental results for the relationship between the acoustic pressure amplitude and the volume fraction of the bubbles. The two-dimensional axi-symmetric results are in good agreement with experimentally observed structure of bubbles close to sonotrode. PMID:23751457

  2. Logistics park development in Slovak Republic

    Microsoft Academic Search

    Marián Šulgan

    2006-01-01

    The paper deals with the actual situation in the Slovak Republic concerning the logistics parks development. It presents the theoretical base of the logistics park development, i.e. the comparative analysis, SWOT analysis, transport infrastructure survey, marketing study and marketing plan for logistics park. It also presents the basic characteristic of logistics park, logistics chains and activities connected with the transport,

  3. Planning and Design for Industry Logistics Park

    Microsoft Academic Search

    Guo Yi; Zhang Xinxin

    2011-01-01

    Regarding a single industry as the target, industry logistics park is the professional logistics park that is specially planned according to industry characteristics. Considering that the industry logistics park has special functions, such as economize on resources, improvement of logistics efficiency and service quality, protection of the environment and so on, industry logistics park's planning and design is different from

  4. Parkes Integer Programming 1 Integer Programming

    E-print Network

    Chen, Yiling

    formulation of an IP we can use primal-dual based methods to design iterative mechanisms. #12;Parkes IntegerParkes Integer Programming 1 ' & $ % Integer Programming David C. Parkes Division of Engineering and Applied Science, Harvard University CS 286r­Spring 2002 #12;Parkes Integer Programming 2

  5. Burning cars in a parking Jean Bertoin

    E-print Network

    Burning cars in a parking Jean Bertoin Abstract Knuth's parking scheme is a model in computer science for hashing with linear probing. One may imagine a circular parking with n sites; cars arrive at each site with unit rate. When a car arrives at a vacant site, it parks there; otherwise it turns

  6. The international politics of national parks

    Microsoft Academic Search

    Karen M. O'Neill

    1996-01-01

    National parks are the keystone institutions of environmental conservation. Because national parks make certain lands part of the state itself, international agencies and nongovernmental organizations that promote national parks propose, in effect, to alter the state, as well as the local economy and state relations with social groups. Has international political pressure caused states to create national parks? I consider

  7. February 2014 STUDENT APPLICATION FOR CAR PARKING

    E-print Network

    Davies, Christopher

    February 2014 STUDENT APPLICATION FOR CAR PARKING Car Parks Office Security & Portering Services@cardiff.ac.uk Limited spaces are available in the Cranbrook car parks for students living at Senghennydd Court only. The charge for car parking for session 2013/14 is Ł132.00, exclusive of VAT, payable in advance. CHEQUES

  8. February 2014 STAFF APPLICATION FOR CAR PARKING

    E-print Network

    Davies, Christopher

    February 2014 STAFF APPLICATION FOR CAR PARKING Car Parks Office Security & Portering Services@cardiff.ac.uk The 2014 fee for staff car parking is 0.75% of gross annual salary or Ł192.00, whichever is lower. Changes) Model (Focus) Colour 1. 2. Car Parks In Order Of Preference 1st : 2nd : 3rd : The following

  9. Standard structures For roadside, car parks,

    E-print Network

    Standard structures For roadside, car parks, visitor information, wayfinding & waymarking Forestry visitor centres. Suitable locations At road entrance to car park/driveway Symbols Up to 5 symbols is for Entrances to medium-sized car parks Suitable locations At road entrance to car park Symbols Up to 3 symbols

  10. Accessibility Application Blue Badge Car Park UK

    E-print Network

    Painter, Kevin

    i Accessibility Application Blue Badge Car Park UK Konstantinos Grassos H00113751 August 2012. In this project, Blue Badge Car Park (BBCP) is presented which is actually a mobile-based park finder application. It specifically focuses on finding parking spaces for wheelchair users, which are indicated by the blue badge

  11. Privacy Impact Assessment OFEO Smithsonian Parking

    E-print Network

    Mathis, Wayne N.

    Privacy Impact Assessment OFEO Smithsonian Parking I. System Identification 1. IT System Name: Smithsonian Parking System 2. System Sponsor Unit: OFEO Office of Protection Services (OPS) Parking Office 3 Parking Office 5. IT System Manager: Michelle T. Gooch, Manager, OCIO FMS Systems Manager 6. PIA Author

  12. EXTENDED PARKING REQUEST COLORADO SCHOOL OF MINES

    E-print Network

    EXTENDED PARKING REQUEST COLORADO SCHOOL OF MINES FACILITIES MANAGEMENT DEPT PARKING SERVICES to Parking Services allows a CSM student or employee to leave his/her vehicle within the campus boundaries for an extended period of time. Vehicle registration and a valid CSM parking permit must be current and visible

  13. PARKING & TRANSPORTATION OFFICE USE ONLY _____Request Approved

    E-print Network

    Acton, Scott

    PARKING & TRANSPORTATION OFFICE USE ONLY _____Request Approved Form last updated 4/19/2010E-UID: C-UID: HEALTH SYSTEM PARKING OFFICE USE ONLY _____Request Denied Parking and Transportation University of Virginia Department of Parking and Transportation Phone: 434-924-7231 Fax: 434-924-3980 Health System

  14. PARKING MASTER PLAN UPDATE BOISE STATE

    E-print Network

    Barrash, Warren

    PARKING MASTER PLAN UPDATE BOISE STATE UNIVERSITY BOISE, IDAHO Prepared for: Boise State University, Department of Transportation and Parking Services August 6, 2010 #12;WALKER PARKING CONSULTANTS 5350 S.walkerparking.com J:\\23-7222-00-BSU_Parking_MasterPlan_09\\Reports\\rpt20100806-Boise_State.doc August 6, 2010 Mr. Jared

  15. Yellowstone National Park: Historic 3-D Photographs Featuring Park Geology

    NSDL National Science Digital Library

    Stoffer Phil

    This source provides a series of 34 historic photographs of well-known geologic landmarks in Yellowstone National Park. The photographs can be viewed individually or as part of a tour that begins at Old Faithful and proceeds in a clockwise route around the park. The images were created by digital manipulation of antique stereographs and they may be viewed as black and white photos or in 3-D using special stereographic glasses.

  16. Association of Park Size, Distance, and Features With Physical Activity in Neighborhood Parks

    Microsoft Academic Search

    Andrew T. Kaczynski; Luke R. Potwarka; Brian E. Saelens

    2008-01-01

    Objectives. We studied whether park size, number of features in the park, and distance to a park from participants' homes were related to a park being used for physical activity. Methods. We collected observational data on 28 specific features from 33 parks. Adult residents in surrounding areas (n = 380) completed 7-day physical activity logs that included the location of

  17. University of Aberdeen Car Parking Policy 1.0 Why have a car parking policy?

    E-print Network

    Pym, David J.

    Document1 University of Aberdeen Car Parking Policy 1.0 Why have a car parking policy to such an extent that its current car park capacity is not sufficient to provide parking for all staff to improve and develop the University further, there is a need to control our car parking facilities

  18. Criteria for Car Parking Allocation System Criteria for Car Parking Allocation System

    E-print Network

    Mottram, Nigel

    Criteria for Car Parking Allocation System Criteria for Car Parking Allocation System 2014-15 Criteria for Car Parking All #12;The issue and control of car parking permits is vested in Estates Services. The annual charges are incorporated in the application form. The car parking charges will be deducted from

  19. 41 CFR 102-74.270 - Are vehicles required to display parking permits in parking facilities?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...2014-01-01 false Are vehicles required to display parking permits in parking facilities...102-74.270 Are vehicles required to display parking permits in parking facilities...designated visitor or service areas must display a parking permit. This requirement...

  20. 41 CFR 102-74.270 - Are vehicles required to display parking permits in parking facilities?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...2010-07-01 false Are vehicles required to display parking permits in parking facilities...102-74.270 Are vehicles required to display parking permits in parking facilities...designated visitor or service areas must display a parking permit. This requirement...

  1. 41 CFR 102-74.270 - Are vehicles required to display parking permits in parking facilities?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...2011-01-01 false Are vehicles required to display parking permits in parking facilities...102-74.270 Are vehicles required to display parking permits in parking facilities...designated visitor or service areas must display a parking permit. This requirement...

  2. 41 CFR 102-74.270 - Are vehicles required to display parking permits in parking facilities?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...2013-07-01 false Are vehicles required to display parking permits in parking facilities...102-74.270 Are vehicles required to display parking permits in parking facilities...designated visitor or service areas must display a parking permit. This requirement...

  3. 41 CFR 102-74.270 - Are vehicles required to display parking permits in parking facilities?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...2012-01-01 false Are vehicles required to display parking permits in parking facilities...102-74.270 Are vehicles required to display parking permits in parking facilities...designated visitor or service areas must display a parking permit. This requirement...

  4. The quandary of local people---Park relations in Nepal's Royal Chitwan National Park

    Microsoft Academic Search

    Karl E. Weber

    1995-01-01

    This paper analyzes five major causes of park-people conflicts that have occurred in Nepal's Royal Chitwan National Park. The causes include illegal transactions of forest products from the park, livestock grazing in the park, illegal hunting and fishing, crop damage, and threats to human and animal life caused by wild animals from the park. The conflicts indicate a reciprocal relationship

  5. Notice to Post on Queen's Parking Website Questions & Answers about Queen's New Parking Rates

    E-print Network

    Ellis, Randy

    Notice to Post on Queen's Parking Website Questions & Answers about Queen's New Parking Rates Q. What are the new parking rates? A. Parking rate increases happen every year, but given the financial situation of our parking facilities, a larger than average increase will happen this year. The university

  6. PARKING INFORMATION The College of Engineering will no longer offer reduced parking permits for Engineering

    E-print Network

    Texas at Arlington, University of

    PARKING INFORMATION The College of Engineering will no longer offer reduced parking permits listed below. Daytime Parking: Please go to the Parking Services Office and purchase a pass for the time period you need. Permits may be purchased daily, weekly or monthly. Evening Exam Parking: Online students

  7. PARKING TIPS Parking is tight at the beginning of each semester

    E-print Network

    Howitt, Ivan

    ­ 1 ­ PARKING TIPS Parking is tight at the beginning of each semester Expect parking to be at near of classes, traffic and parking patterns settle down. Permit enforcement begins on the first day of class on the first day of class: · plantopaytoparkinaVisitordeckormeteredlot.Youwill not be allowed to park in main

  8. IL-27 Regulates IL-18 binding protein in skin resident cells.

    PubMed

    Wittmann, Miriam; Doble, Rosella; Bachmann, Malte; Pfeilschifter, Josef; Werfel, Thomas; Mühl, Heiko

    2012-01-01

    IL-18 is an important mediator involved in chronic inflammatory conditions such as cutaneous lupus erythematosus, psoriasis and chronic eczema. An imbalance between IL-18 and its endogenous antagonist IL-18 binding protein (BP) may account for increased IL-18 activity. IL-27 is a cytokine with dual function displaying pro- and anti-inflammatory properties. Here we provide evidence for a yet not described anti-inflammatory mode of action on skin resident cells. Human keratinocytes and surprisingly also fibroblasts (which do not produce any IL-18) show a robust, dose-dependent and highly inducible mRNA expression and secretion of IL-18BP upon IL-27 stimulation. Other IL-12 family members failed to induce IL-18BP. The production of IL-18BP peaked between 48-72 h after stimulation and was sustained for up to 96 h. Investigation of the signalling pathway showed that IL-27 activates STAT1 in human keratinocytes and that a proximal GAS site at the IL-18BP promoter is of importance for the functional activity of IL-27. The data are in support of a significant anti-inflammatory effect of IL-27 on skin resident cells. An important novel property of IL-27 in skin pathobiology may be to counter-regulate IL-18 activities by acting on keratinocytes and importantly also on dermal fibroblasts. PMID:22761702

  9. Involvement of IL17A, IL17F and IL23R Polymorphisms in Colorectal Cancer Therapy

    PubMed Central

    Omrane, Inés; Medimegh, Imen; Baroudi, Olfa; Ayari, Hager; Bedhiafi, Walid; Stambouli, Nejla; Ferchichi, Marwa; Kourda, Nadia; Bignon, Yves-Jean; Uhrhammer, Nancy; Mezlini, Amel; Bougatef, Karim; Benammar-Elgaaied, Amel

    2015-01-01

    IL23/IL17 pathway plays an important role in the development of inflammatory bowel diseases (IBD). In general, the genes encoding the cytokines are genetically polymorphic and polymorphisms in genes IL23R and IL17 have been proved to be associated with its susceptibility to inflammatory diseases as well as cancer including colorectal cancer. Moreover, it has been shown that these interleukins are involved in anti-tumor or pro-tumor effects of various cancers. Previously, we showed that there is a significant association between IL17A, IL17F and IL23R polymorphisms as well as the occurrence of colorectal cancer and the clinical features of the disease. The purpose of the present work is to investigate an association between IL17A, IL17F and IL23R polymorphisms in 102 Tunisian patients with colorectal cancer treatment. The association was analyzed by statistical tools. We found that patients with mutated genotypes of IL17A G197A SNP could be a risk factor for the inefficiency of chemotherapy and radiotherapy. Unlike IL17F variant, patients with wild type genotypes require surgery and adjuvant chemotherapy. On the one hand, we found no evidence that supports a significant association between IL23R polymorphism and the combined genotypes of these three genes and the colorectal cancer treatment. On the other hand, we showed that there is an important interaction between IL17A/IL17F polymorphisms and the stage of the disease as well as its treatment. Finally, patients with IL17F wild type genotype highlighted that there is a valid longer OS without all treatments and with radiotherapy and a neoadjuvant chemotherapy. In contrast, we observed that there are no relationships between IL17A, IL23R and the survival of these patients neither with nor without the treatment. Our results suggest that polymorphisms in IL17A and IL17F genes may be a predictive source of colorectal cancer therapy type. Therefore, IL17F may serve as an independent prognostic factor for overall survival in patients with colorectal cancer. PMID:26083022

  10. IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen.

    PubMed

    Ooi, Joshua D; Phoon, Richard K S; Holdsworth, Stephen R; Kitching, A Richard

    2009-05-01

    The autoantigen in Goodpasture disease is the noncollagenous domain of alpha3 type IV collagen [alpha3(IV)NC1]. We previously demonstrated that IL-12p40(-/-) mice are protected from experimental autoimmune anti-glomerular basement membrane (anti-GBM) glomerulonephritis, seemingly defining a role for IL-12 in this disease; however, the recent identification of IL-23, a heterodimer composed of IL-12p40 and IL-23p19 subunits, raises the possibility that IL-23, rather than IL-12, may modulate this disease instead. We immunized wild-type, IL-12p35(-/-) (IL-12 deficient, IL-23 intact), IL-12p40(-/-) (deficient in both IL-12 and IL-23), and IL-23p19(-/-) (IL-12 intact, IL-23 deficient) mice with recombinant mouse alpha3(IV)NC1. Wild-type mice developed autoreactivity to alpha3(IV)NC1: Humoral responses, cellular responses, renal histologic abnormalities, leukocyte accumulation, autoantibody deposition, and IL-17A mRNA expression (a cytokine produced by the IL-23-maintained Th17 subset). IL-23 but not IL-12 was detected in the immune system. Regardless of the presence of IL-12, mice deficient in IL-23 were protected, but mice with IL-23 were not. Both IL-23-deficient strains exhibited lower autoantibody titers, reduced cellular reactivity, diminished cytokine production (IFN-gamma [Th1], IL-17A [Th17], TNF, and monocyte chemoattractant protein 1), and less renal disease and glomerular IgG deposition. The deficient responses in the absence of IL-23 were not due to increased regulatory T cells; IL-12p40(-/-) and IL-23p19(-/-) mice did not show increased proportions of CD4(+)CD25(+)FoxP3(+) cells or IL-10 levels early in the immune response. In conclusion, autoreactivity to the Goodpasture antigen is directed primarily by IL-23, absence of which results in hyporeactivity including but extending beyond a deficient Th17 response. PMID:19357249

  11. The Science Behind Jurassic Park

    NSDL National Science Digital Library

    "The Science Behind Jurassic Park" is an html document describing how world renowned paleontologist Jack Horner is using computers and CAT scan machines to peer inside 30 million year old dinosaur fossils.

  12. Dead Mans Run parking for

    E-print Network

    Farritor, Shane

    Dead ManŐs Run 44THSTREET parking for state vehicles Dead ManŐs Run East Campus Recr eation Fields Industry Complex C.Y. Thompson Library Biochemistry Hall Kiesselbach Crops Research Lab Water Sciences Lab

  13. Dead Mans Run parking for

    E-print Network

    Farritor, Shane

    Dead ManŐs Run 44THSTREET parking for state vehicles Dead ManŐs Run East Campus Recr eation Fields Biochemistry Hall Kiesselbach Crops Research Lab Water Sciences Lab Forestry Hall USDA Insect Lab Insectary

  14. Dead Mans Run parking for

    E-print Network

    Farritor, Shane

    Dead ManŐs Run 44THSTREET parking for state vehicles Dead ManŐs Run East Campus Recr eation Fields Water Sciences Lab Forestry Hall USDA Insect Lab Insectary College of Dentistry Barkley Memorial Center

  15. Arches National Park - Nature and Science

    NSDL National Science Digital Library

    This National Park Service (NPS) website highlights the natural resources of Arches National Park, in addition to the sandstone arches for which the park is famous. Details about the park include the animals that inhabit the area (amphibians, birds, mammals and reptiles), natural features (deserts, geologic formations, pools, potholes and soils), environmental factors facing the park (invasive species, perigrine falcons, bighorn sheep), and plants (cacti, grasses, lichens, mosses, liverworts, trees, shrubs and wildflowers).

  16. Urban Parks: Volunteers and Civic Engagement 

    E-print Network

    Schuett, Michael A.

    2007-03-02

    citizens in local efforts and events. ParkScan ? San Francisco, California ParkScan is a partnership of the San Francis- co Recreation and Park Department and the Neighborhood Parks Council, an advocacy group. Trained observers track park and play...- ground maintenance issues in San Francisco and in the surrounding county and use a Web- based reporting system. Maintenance condi- tions are made public and can be tracked at www.parkscansf.org/parkscan.aspx. ACE ? Arlington, Texas The ACE (Action...

  17. IL1: discoveries, controversies and future directions

    Microsoft Academic Search

    Charles A. Dinarello

    2010-01-01

    Although there has been a great amount of progress in the 25 years since the first reporting of the cDNA for IL-1alpha and IL-1beta, the history of IL-1 goes back to the early 1940s. In fact, the entire field of inflammatory cytokines, TLR and the innate immune response can be found in the story of IL-1. This Viewpoint follows the

  18. Parking permit rate changes set at Homewood and Eastern

    E-print Network

    Worley, Paul

    Parking permit rate changes set at Homewood and Eastern New permit parking rates go into effect on July 1 for parking lots and garages on the Homewood and Eastern campuses. Since parking is paid. Faculty hangtag parking and general garage parking are $94 per month. Reserved parking spaces at the West

  19. 75 FR 9095 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ...RNAV (GPS) RWY 12, Orig Stuart, FL, Witham Field, RNAV (GPS) RWY 30, Orig Lagrange, GA, Lagrange-Callaway, ILS OR LOC RWY 31, Amdt 2 Lagrange, GA, Lagrange-Callaway, RNAV (GPS) RWY 3, Orig Lagrange, GA,...

  20. Contribution of Public Parks to Physical Activity

    PubMed Central

    Cohen, Deborah A.; McKenzie, Thomas L.; Sehgal, Amber; Williamson, Stephanie; Golinelli, Daniela; Lurie, Nicole

    2007-01-01

    Objectives. Parks provide places for people to experience nature, engage in physical activity, and relax. We studied how residents in low-income, minority communities use public, urban neighborhood parks and how parks contribute to physical activity. Methods. In 8 public parks, we used direct observation to document the number, gender, race/ethnicity, age group, and activity level of park users 4 times per day, 7 days per week. We also interviewed 713 park users and 605 area residents living within 2 miles of each park. Results. On average, over 2000 individuals were counted in each park, and about two thirds were sedentary when observed. More males than females used the parks, and males were twice as likely to be vigorously active. Interviewees identified the park as the most common place they exercised. Both park use and exercise levels of individuals were predicted by proximity of their residence to the park. Conclusions. Public parks are critical resources for physical activity in minority communities. Because residential proximity is strongly associated with physical activity and park use, the number and location of parks are currently insufficient to serve local populations well. PMID:17267728

  1. Sustainable Housing for Park Rangers in Big Bend National Park, Texas

    E-print Network

    Garrison, M.; Griswold, S.

    1996-01-01

    the direction of Associate Professor Glenn Hill, have designed environmentally friendly "green" homes for park rangers in Big Bend National Park, Texas. With funding from the National Park Foundation and a construction commitment of 1.2 million dollars...

  2. IL10 AND IL12 ARE THE MAIN REGULATORY CYTOKINES IN VISCERAL LEISHMANIASIS

    Microsoft Academic Search

    Ol??via Bacellar; Argemiro D'oliveira; Selma Jerônimo; Edgar M Carvalho

    2000-01-01

    Visceral leishmaniasis (VL) is characterized by the absence of cytokines such as IFN-? and IL-12. Cure of VL is associated with a restoration of the ability to make these cytokines. The aim of the present study was to evaluate the role of IL-12 in the recovery of the ability to produce IFN-? and to test whether or not IL-4 IL-10

  3. Structural and Biophysical Studies of the Human IL-7/IL-7R[alpha] Complex

    SciTech Connect

    McElroy, Craig A.; Dohm, Julie A.; Walsh, Scott T.R.; (OSU); (UPENN)

    2009-03-06

    IL-7 and IL-7R{alpha} bind the {gamma}{sub c} receptor, forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells. We report that the IL-7R{alpha} ectodomain uses glycosylation to modulate its binding constants to IL-7, unlike the other receptors in the {gamma}{sub c} family. IL-7 binds glycosylated IL-7R{alpha} 300-fold more tightly than unglycosylated IL-7R{alpha}, and the enhanced affinity is attributed primarily to an accelerated on rate. Structural comparison of IL-7 in complex to both forms of IL-7R{alpha} reveals that glycosylation does not participate directly in the binding interface. The SCID mutations of IL-7R{alpha} locate outside the binding interface with IL-7, suggesting that the expressed mutations cause protein folding defects in IL-7R{alpha}. The IL-7/IL-7R{alpha} structures provide a window into the molecular recognition events of the IL-7 signaling cascade and provide sites to target for designing new therapeutics to treat IL-7-related diseases.

  4. Multinational underground nuclear parks

    SciTech Connect

    Myers, C.W. [Nuclear Engineering and Nonproliferation Division, Los Alamos National Laboratory, MS F650, Los Alamos, NM 87544 (United States); Giraud, K.M. [Wolf Creek Nuclear Operating Corporation, 1550 Oxen Lane NE, P.O. Box 411, Burlington, KS 66839-0411 (United States)

    2013-07-01

    Newcomer countries expected to develop new nuclear power programs by 2030 are being encouraged by the International Atomic Energy Agency to explore the use of shared facilities for spent fuel storage and geologic disposal. Multinational underground nuclear parks (M-UNPs) are an option for sharing such facilities. Newcomer countries with suitable bedrock conditions could volunteer to host M-UNPs. M-UNPs would include back-end fuel cycle facilities, in open or closed fuel cycle configurations, with sufficient capacity to enable M-UNP host countries to provide for-fee waste management services to partner countries, and to manage waste from the M-UNP power reactors. M-UNP potential advantages include: the option for decades of spent fuel storage; fuel-cycle policy flexibility; increased proliferation resistance; high margin of physical security against attack; and high margin of containment capability in the event of beyond-design-basis accidents, thereby reducing the risk of Fukushima-like radiological contamination of surface lands. A hypothetical M-UNP in crystalline rock with facilities for small modular reactors, spent fuel storage, reprocessing, and geologic disposal is described using a room-and-pillar reference-design cavern. Underground construction cost is judged tractable through use of modern excavation technology and careful site selection. (authors)

  5. Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene

    SciTech Connect

    Isshiki, H.; Akira, S.; Tanabe, O.; Nakajima, T.; Shimamoto, T.; Hirano, T.; Kishimoto, T. (Div. of Cellular Immunology, Institute for Molecular and Cellular Biology, Osaka Univ., 1-3 Yamada-oka, Suita-city, Osaka 565 (JP))

    1990-06-01

    The interleukin-6 (IL-6) promoter is rapidly and transiently activated with other cytokines, including IL-1, tumor necrosis factor, and platelet-derived growth factor, as well as phorbol esters and agents that increase intracellular cyclic AMP. In this study, the authors have investigated {ital cis}-acting regulatory elements and {ital trans}-acting factors responsible for IL-1-induced IL-6 gene expression. Studies on the 5{prime} deletion mutants of the human IL-6 gene suggested that the IL-1-responsive element was mapped within the IL-6 promoter region ({minus} 180 to {minus} 123) which was homologous to the c-{ital fos} serum-responsive enhancer element. Gel retardation assay identified two types of nuclear factors that bound to this region, one constitutive and the other inducible. These two factors recognized a 14-base-pair (bp) palindromic sequence, ACATTGCACAATCT. Furthermore, three copies of this 14-bp palindrome conferred IL-1 responsiveness to the basal enhancerless IL-6 promoter, indicating that a 14-bp-dyad symmetry sequence was an IL-1-responsive element in the IL-6 gene.

  6. 76 FR 29274 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ...TA-W-80,024; MIDI Music Center, Inc., DBA Lowrey Organ Co., Including On-Site Leased Workers From Prime Staffing, LaGrange Park, IL, and Elmhurst, IL: February 16, 2010. TA-W-80,067; Lane Punch Corporation, Including On-Site...

  7. Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes.

    PubMed Central

    Fujihashi, K; Kawabata, S; Hiroi, T; Yamamoto, M; McGhee, J R; Nishikawa, S; Kiyono, H

    1996-01-01

    In this study, we describe the interaction between cytokine and cytokine receptor (R) for the activation and proliferation of gamma delta T-cell receptor-positive T cells (gamma delta T cells). gamma delta T cells isolated from murine intestinal intraepithelial lymphocytes (IELs) were separated into gamma delta (Dim) and gamma delta (Bright) fractions according to the intensity of gamma delta T-cell receptor expression. The gamma delta T cells express low levels of IL-2R and IL-7R as shown by flow cytometry and reverse transcriptase-PCR analysis, whereas gamma delta (Bright) T cells did not express either receptor. Our study also revealed that recombinant marine (rm)IL-2 and rmIL-7 reciprocally induced high expressions of IL-7R and IL-2R, respectively, on gamma delta (Dim) T cells but not on gamma delta (Bright) cells. Thus, treatment of gamma delta (Dim) T cells with rmIL-2 and rmIL-7 resulted in high proliferative responses, whereas gamma delta (Bright) T cells did not respond to these two cytokines. The sources of these two cytokines for gamma delta T cells were neighboring epithelial cells (IL-7) and alpha beta T cells (IL-2 and IL-7). Cytokine signaling by IL-2 and IL-7 from alpha beta T cells and epithelial cells was necessary for the expression of IL-7R and IL-2R, respectively, on a subset of gamma delta T cells (e.g., gamma delta (Dim) T cells) in mucosa-associated tissue for subsequent activation and cell division. Images Fig. 1 Fig. 4 Fig. 5 PMID:8622984

  8. Extended Hamilton-Lagrange formalism and its application to Feynman's path integral for relativistic quantum physics

    E-print Network

    Jürgen Struckmeier

    2015-01-19

    With this paper, a consistent and comprehensive treatise on the foundations of the extended Hamilton-Lagrange formalism will be presented. In this formalism, the system's dynamics is parametrized along a time-like system evolution parameter $s$, and the physical time $t$ is treated as a dependent variable $t(s)$ on equal footing with all other configuration space variables $q^{i}(s)$. In the action principle, the conventional classical action $L\\,dt$ is then replaced by the generalized action $L_{e}ds$, with $L$ and $L_{e}$ denoting the conventional and the extended Lagrangian, respectively. In the existing literature, the discussion is restricted to only those extended Lagrangians $L_{e}$ that are homogeneous forms of first order in the velocities. It is shown that a class of extended Lagrangians $L_{e}$ exists that are correlated to corresponding conventional Lagrangians $L$ without being homogeneous functions in the velocities. Then the Legendre transformation of $L_{e}$ to an extended Hamiltonian $H_{e}$ exists. With this class of extended Hamiltonians, an extended canonical formalism is presented that is completely analogous to the conventional Hamiltonian formalism. The physical time $t$ and the negative value of the conventional Hamiltonian then constitute and an additional pair of conjugate canonical variables. The extended formalism also includes a theory of extended canonical transformations, where the time variable $t(s)$ is also subject to transformation. In the extended formalism, the system's dynamics is described as a motion on a hypersurface within an extended phase space of even dimension. It is shown that the hypersurface condition does not embody a constraint as the condition is automatically satisfied on the system path that is given by the solution of the extended set of canonical equations.

  9. 78 FR 76697 - The Central Valley Fund Il SBIC, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-18

    ...730). The Central Valley Fund Il SBIC, L.P. is proposing to provide financing to Quest Discovery Services, Inc., 981 Ridder Park Drive, San Jose, CA 95131. The financing will be used, in part, for working capital, to pay the seller, to pay...

  10. IL-37 requires the receptors IL-18R? and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.

    PubMed

    Nold-Petry, Claudia A; Lo, Camden Y; Rudloff, Ina; Elgass, Kirstin D; Li, Suzhao; Gantier, Michael P; Lotz-Havla, Amelie S; Gersting, Sřren W; Cho, Steven X; Lao, Jason C; Ellisdon, Andrew M; Rotter, Björn; Azam, Tania; Mangan, Niamh E; Rossello, Fernando J; Whisstock, James C; Bufler, Philip; Garlanda, Cecilia; Mantovani, Alberto; Dinarello, Charles A; Nold, Marcel F

    2015-04-01

    Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan members of the IL-1 ligand family and IL-1 receptor family, respectively. Here we demonstrate formation and function of the endogenous ligand-receptor complex IL-37-IL-1R8-IL-18R?. The tripartite complex assembled rapidly on the surface of peripheral blood mononuclear cells upon stimulation with lipopolysaccharide. Silencing of IL-1R8 or IL-18R? impaired the anti-inflammatory activity of IL-37. Whereas mice with transgenic expression of IL-37 (IL-37tg mice) with intact IL-1R8 were protected from endotoxemia, IL-1R8-deficient IL-37tg mice were not. Proteomic and transcriptomic investigations revealed that IL-37 used IL-1R8 to harness the anti-inflammatory properties of the signaling molecules Mer, PTEN, STAT3 and p62(dok) and to inhibit the kinases Fyn and TAK1 and the transcription factor NF-?B, as well as mitogen-activated protein kinases. Furthermore, IL-37-IL-1R8 exerted a pseudo-starvational effect on the metabolic checkpoint kinase mTOR. IL-37 thus bound to IL-18R? and exploited IL-1R8 to activate a multifaceted intracellular anti-inflammatory program. PMID:25729923

  11. Disease-associated functions of IL33: the new kid in the IL1 family

    Microsoft Academic Search

    Nick I. Pitman; Iain B. McInnes; Foo Y. Liew

    2010-01-01

    Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The IL-33 receptor, consisting of ST2 and IL-1 receptor accessory protein, is also widely expressed, particularly by T helper 2 (TH2) cells and mast cells. IL-33 is host-protective against helminth infection and

  12. IL4 and IL10 Inhibition of Spontaneous Monocyte Apoptosis Is Associated with Flip Upregulation

    Microsoft Academic Search

    Joy Eslick; John C. Scatizzi; Lee Albee; Emily Bickel; Kathleen Bradley; Harris Perlman

    2004-01-01

    Human peripheral blood monocytes undergo spontaneous apoptosis in culture. Spontaneous monocyte apoptosis is regulated by the death ligand, Fas Ligand (FasL) binding to its receptor Fas. The pro-inflammatory molecules, LPS and IL-1ß, prevent spontaneous monocyte apoptosis. Here, we demonstrate that the anti-inflammatory cytokines IL-4 and IL-10 inhibit spontaneous monocyte apoptosis compared to control-treated cells. IL-4- or IL-10-mediated suppression of spontaneous

  13. A Brief History of IL-9

    PubMed Central

    Goswami, Ritobrata; Kaplan, Mark H.

    2011-01-01

    Interleukin-9 was first described in the late 1980s as a member of a growing number of cytokines that had pleiotropic functions in the immune system. Although many biological functions have been attributed to IL-9, it remains an understudied cytokine. A resurgence of interest in IL-9 has been spurred by recent work demonstrating a role for IL-9 in regulating inflammatory immunity, and in defining the transcription factors that activate the Il9 gene in cells that most efficiently produce IL-9. In this review we summarize the characterization of IL-9 biological activities, highlight roles for the cytokine that are clearly defined, and outline questions regarding IL-9 functions that still require further exploration. PMID:21368237

  14. IL-21 and IL-21 Receptor Expression in Lymphocytes and Neurons in Multiple Sclerosis Brain

    PubMed Central

    Tzartos, John S.; Craner, Matthew J.; Friese, Manuel A.; Jakobsen, Karen B.; Newcombe, Jia; Esiri, Margaret M.; Fugger, Lars

    2011-01-01

    IL-17–producing CD4+ T cells (Th-17) contribute to the pathogenesis of experimental autoimmune encephalomyelitis and are associated with active disease in multiple sclerosis (MS). In addition to IL-17, Th-17 cells can also express IL-21, IL-22, and IL-6 under Th-17–polarizing conditions (IL-6 and transforming growth factor-?). In this study we investigated IL-21 and IL-21 receptor (IL-21R) expression in MS lesions by in situ hybridization and immunohistochemistry. We detected strongly IL-21+ infiltrating cells predominantly in acute but also in chronic active white matter MS lesions in which IL-21 expression was restricted to CD4+ cells. In contrast, IL-21R was much more broadly distributed on CD4+, CD19+, and CD8+ lymphocytes but not major histocompatibility complex class-II+ macrophages/microglia. Interestingly, in cortical areas we detected both IL-21 and IL-21R expression by neurons. These findings suggest role(s) for IL-21 in both the acute and chronic stages of MS via direct effects on T and B lymphocytes and, demonstrated for the first time, also on neurons. PMID:21281812

  15. IL1 pathways in inflammation and human diseases

    Microsoft Academic Search

    Céline Lamacchia; Gaby Palmer; Cem Gabay

    2010-01-01

    Interleukin (IL)-1 was first cloned in the 1980s, and rapidly emerged as a key player in the regulation of inflammatory processes. The term IL-1 refers to two cytokines, IL-1? and IL-1?, which are encoded by two separate genes. The effects of IL-1 are tightly controlled by several naturally occurring inhibitors, such as IL-1 receptor antagonist (IL-1Ra), IL-1 receptor type II

  16. An analysis of Utah State Park visitors 

    E-print Network

    Burns, Dennis C.

    1988-01-01

    studies Approach 3 7 3. RESULTS 15 Average Length of Stay Day-users Versus Campers Activities in State Parks Type of Group and Origin Decision to Visit State Parks Attitudinal Questions 4. CONCLUSIONS AND IMPLICATIONS 15 17 19 25 31 37 42... of vehicle counts used to calculate activities 13 3 Average length of stay, by park 16 4 Numbers and percentages of day-users and campers, by park 18 5 Statewide summary of activities in the state parks 21 6 Summary matrix of activities by park; Rank...

  17. Tour of Park Geology: Plate Tectonics

    NSDL National Science Digital Library

    This National Park Service (NPS) site provides links to geology field notes providing information about National Parks, National Monuments, and National Recreation Areas that have to do with plate tectonics. The site also has illustrations and descriptions of different plate boundaries. The parks are divided into categories depending on which type of plate boundary they are located on. This includes divergent boundaries(active and ancient), convergent boundaries (ocean-ocean, continent-continent, continent-ocean), transform faults, hot spots, and accreted terrains. Parks referenced include Virgin Islands National Park, Florissant Fossil Beds National Monument, Hawaii Volcanoes National Park, and many more.

  18. Geology Fieldnotes: Badlands National Park, South Dakota

    NSDL National Science Digital Library

    Badlands National Park, located in southwestern South Dakota, consists of 244,000 acres of sharply eroded buttes, pinnacles and spires blended with the largest, protected mixed grass prairie in the United States. Features include information on park geology, maps, photographs, visitor information, links to related publications, and lesson plans for teaching geology with National Park examples. The park geology section discusses the Park's geologic history during the Eocene and Oligocene epochs and the rich fossil deposits found there. Maps of the park and the surrounding area are included.

  19. IL22/IL-22R Pathway Induces Cell Survival in Human Glioblastoma Cells

    PubMed Central

    Akil, Hussein; Abbaci, Amazigh; Lalloué, Fabrice; Bessette, Barbara; Costes, Léa M. M.; Domballe, Linda; Charreau, Sandrine; Guilloteau, Karline; Karayan-Tapon, Lucie; Bernard, François-Xavier; Morel, Franck

    2015-01-01

    Interleukin-22 (IL-22) is a member of the IL-10 cytokine family that binds to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2. IL-22R expression was initially characterized on epithelial cells, and plays an essential role in a number of inflammatory diseases. Recently, a functional receptor was detected on cancer cells such as hepatocarcinoma and lung carcinoma, but its presence was not reported in glioblastoma (GBM). Two GBM cell lines and 10 primary cell lines established from patients undergoing surgery for malignant GBM were used to investigate the expression of IL-22 and IL-22R by using quantitative RT-PCR, western blotting and confocal microscopy studies. The role of IL-22 in proliferation and survival of GBM cell lines was investigated in vitro by BrdU and ELISA cell death assays. We report herein that the two subunits of the IL-22R complex are expressed on human GBM cells. Their activation, depending on exogenous IL-22, induced antiapoptotic effect and cell proliferation. IL-22 treatment of GBM cells resulted in increased levels of phosphorylated Akt, STAT3 signaling protein and its downstream antiapoptotic protein Bcl-xL and decreased level of phosphorylated ERK1/2. In addition, IL-22R subunits were expressed in all the 10 tested primary cell lines established from GBM tumors. Our results showed that IL-22R is expressed on GBM established and primary cell lines. Depending on STAT3, ERK1/2 and PI3K/Akt pathways, IL-22 induced GBM cell survival. These data are consistent with a potential role of IL-22R in tumorigenesis of GBM. Since endogenous IL-22 was not detected in all studied GBM cells, we hypothesize that IL-22R could be activated by immune microenvironmental IL-22 producing cells. PMID:25793261

  20. Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4.

    PubMed Central

    Fujihashi, K.; Beagley, K. W.; Kono, Y.; Aicher, W. K.; Yamamoto, M.; DiFabio, S.; Xu-Amano, J.; McGhee, J. R.; Kiyono, H.

    1993-01-01

    A unique characteristic of the localized inflammatory tissue in the periodontium (e.g., adult periodontitis [AP]) is the accumulation of IgG (IgG1 > IgG2 > IgG3 > or = IgG4) followed by IgA plasma cells (IgA1 > IgA2). However, the exact molecular mechanisms contributing to these elevated B-cell responses at the local disease site are still unknown. Thus, this study has examined the production of cytokines of importance in B-cell responses, e.g., interleukin (IL)-2, IL-4, IL-5, and IL-6 by gingival mononuclear cells (GMC) isolated from patients in severe stages of AP. These cytokines were assessed at the protein and messenger (m)RNA levels to understand their importance for the observed increased B-cell responses present in these tissues. Among the four cytokines tested by respective cytokine-specific, polymerase chain reaction and dot-blot hybridization, high levels of IL-5- and IL-6-specific mRNA were noted in GMC freshly isolated from AP patients. On the other hand, specific message for IL-2 and IL-4 were not present. Further, the analysis of culture supernatants of GMC also revealed that cells from AP patients spontaneously produced IL-5 and IL-6 but not IL-2 and IL-4. In contrast, when peripheral blood mononuclear cells isolated from the same patients were examined for these cytokines, no detectable levels of mRNA or secreted cytokines were noted. These results showed that GMC from localized inflammatory tissues in severe stages of AP possess a distinct cytokine profile represented by high levels of IL-5 and IL-6 mRNA expression and protein synthesis, whereas IL-2 and IL-4 were not detected. Further, this study supports the concept that AP is a localized inflammatory disease, because GMC from the inflamed tissue actively produce IL-5 and IL-6, whereas peripheral blood mononuclear cells from the same patients do not. Images Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 PMID:8475996

  1. IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms

    PubMed Central

    Hung, Li-Yin; Lewkowich, Ian P.; Dawson, Lucas A.; Downey, Jordan; Yang, Yanfen; Smith, Dirk E.; Herbert, De'Broski R.

    2013-01-01

    Parasitic helminths are a major cause of chronic human disease, affecting more than 3 billion people worldwide. Host protection against most parasitic helminths relies upon Type 2 cytokine production, but the mechanisms that regulate interleukin (IL) 4 and 13 production from CD4+ T helper 2 cells (TH2) and innate lymphoid type 2 cells (ILC2s) remain incompletely understood. The epithelial cell-derived cytokines IL-25 and IL-33 promote Type 2 responses, but the extent of functional redundancy between these cytokines is unclear and whether Type 2 memory relies upon either IL-25 or IL-33 is unknown. Herein, we demonstrate a pivotal role for IL-33 in driving primary and anamnestic immunity against the rodent hookworm Nippostrongylus brasiliensis. IL-33–deficient mice have a selective defect in ILC2–derived IL-13 during both primary and secondary challenge infections but generate stronger canonical CD4+ T helper 2 cells responses (IL-4, IgE, mast cells, and basophils) than WT controls. Lack of IL-13 production in IL-33–deficient mice impairs resistin-like molecule beta (RELM?) expression and eosinophil recruitment, which are two mechanisms that eliminate N. brasiliensis parasites from infected hosts. Thus, IL-33 is requisite for IL-13 but not IL-4–driven Type 2 responses during hookworm infection. PMID:23248269

  2. Targeting IL-33 in Autoimmunity and Inflammation.

    PubMed

    Theoharides, Theoharis C; Petra, Anastasia I; Taracanova, Alexandra; Panagiotidou, Smaro; Conti, Pio

    2015-07-01

    Interleukin-33 (IL-33) belongs to the IL-1 family of cytokines. Whereas IL-1 is processed and released by live immune cells in response to infection or other triggers, IL-33 is mostly released as a danger signal ("alarmin") from damaged cells. IL-33 may also be processed and released from activated mast cells (MCs) with subsequent autocrine and paracrine actions. IL-33 augments the stimulatory effects of IgE and substance P on MCs but can also trigger release of cytokines from MCs on its own. Blood IL-33 levels are increased in asthma, atopic dermatitis, multiple sclerosis, rheumatoid arthritis, and Sjögren's syndrome. However, prolonged elevation of IL-33 downregulates Fc?RI and may be protective in atherosclerosis, suggesting different roles in immune-regulated diseases. Even though neutralizing IL-33, knocking-down its receptor, or using its soluble "decoy" receptor has resulted in anti-inflammatory effects, there appear to be different outcomes in different tissues. Hence, selective regulation of IL-33 synthesis, release, and signaling may be required to provide effective treatment options. PMID:25906776

  3. Disabled Parking & Access Plan Campus Disabled Persons (DP)

    E-print Network

    de Lijser, Peter

    Disabled Parking & Access Plan Campus Disabled Persons (DP) Parking and Access Plan For CSU Executive Deans Meeting Stanislaus Campus June 2007 #12;Disabled Parking & Access Plan Core Team: · Michael & Construction · Paul Miller, Director ­ Disabled Student Services · Joe Ferrer, Director ­ Parking

  4. PARKING SERVICES SERVICE REQUEST FORM Form revised 21March 2011

    E-print Network

    PARKING SERVICES SERVICE REQUEST FORM Form revised 21March 2011 Request for (please check one): Contact Phone No. Fax No. __ Parking Scripts - __________ (specify quantity) Supv, Parking Services 24832 25386 __ Campus Maps - __________ (specify quantity) Supv Parking Services 24832 25386 __ Visitors

  5. Robust Calculation of Chromatic Dispersion Coefficients of Optical Fibers From Numerically Determined Effective Indices Using Chebyshev Lagrange Interpolation Polynomials

    NASA Astrophysics Data System (ADS)

    Chiang, Po-Jui; Yu, Chin-Ping; Chang, Hung-Chun

    2006-11-01

    Numerical calculation of chromatic dispersion coefficients of optical fibers is conducted using a procedure involving Chebyshev Lagrange interpolation polynomials. Only numerically determined effective indices at several wavelengths are needed for obtaining the dispersion curve, and no direct numerical differentiation of the effective refractive index is involved. A silica-filled metallic rectangular waveguide having analytical solutions for the effective refractive index and the chromatic dispersion is used as an example for confirming the accuracy and efficiency of the proposed method. The method is then also applied to the analysis of holey fibers.

  6. THE LAGRANGE EQUILIBRIUM POINTS L{sub 4} AND L{sub 5} IN BLACK HOLE BINARY SYSTEM

    SciTech Connect

    Schnittman, Jeremy D. [Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD 21218 (United States)

    2010-11-20

    We calculate the location and stability of the L{sub 4} and L{sub 5} Lagrange equilibrium points in the circular restricted three-body problem as the binary system evolves via gravitational radiation losses. Relative to the purely Newtonian case, we find that the L{sub 4} equilibrium point moves toward the secondary mass and becomes slightly less stable, while the L{sub 5} point moves away from the secondary and gains in stability. We discuss a number of astrophysical applications of these results, in particular as a mechanism for producing electromagnetic counterparts to gravitational-wave signals.

  7. Modulation of IL1?, IL6, IL8, TNF-?, and TGF-? secretions by alveolar macrophages under NO 2 exposure

    Microsoft Academic Search

    K. Kienast; M. Knorst; J. Müller-Quernheim; R. Ferlinz

    1996-01-01

    Activated alveolar macrophages (AMs) secrete interleukine (IL)1ß, IL-6, IL-8, tumor necrosis factor-a (TNF-a), and transforming growth factor-ß (TGF-ß), whose inflammatory and fibroblast-activating characteristics may play a role in the maintenance of pulmonary inflammatory processes and subsequent fibrosis. Human AMs were transferred to a gas cylinder and exposed to NO2 in concentrations ranging from 0.1 to 0.5 ppm in synthetic air

  8. The Access Almanac: Solar Parking Requirements

    E-print Network

    Shoup, Donald

    2012-01-01

    charging electric cars. If the solar energy is being storedcars can feel green when they park in the shade of solarSolar canopies over parking lots can provide some of the electricity needed for these cars

  9. Parking & Transportation Department RESIDENT -PERSONAL INFORMATION

    E-print Network

    Oliver, Douglas L.

    Parking & Transportation Department RESIDENT - PERSONAL INFORMATION Date know if you are interested in: Public Transportation Car Pool Van Pool _____________________________________________________________________________________ Please be sure to contact the Parking & Transportation Department with any changes to your information, i

  10. WIND DATA REPORT Deer Island Parking Lot

    E-print Network

    Massachusetts at Amherst, University of

    WIND DATA REPORT Deer Island Parking Lot May 1, 2003 ­ July 15, 2003 Prepared for Massachusetts........................................................................................................................ 16 TABLE OF FIGURES Figure 1 - Site location at Deer Island Parking Lot site................

  11. Parking on a Random Tree

    E-print Network

    H. Dehling; S. R. Fleurke; C. Kuelske

    2007-11-26

    Consider an infinite tree with random degrees, i.i.d. over the sites, with a prescribed probability distribution with generating function G(s). We consider the following variation of Renyi's parking problem, alternatively called blocking RSA: at every vertex of the tree a particle (or car) arrives with rate one. The particle sticks to the vertex whenever the vertex and all of its nearest neighbors are not occupied yet. We provide an explicit expression for the so-called parking constant in terms of the generating function.

  12. White -Parking Services Yellow Parking Services, return to appellant with reply Pink -Appellant's initial copy PLEASE READ REVERSE SIDE

    E-print Network

    White - Parking Services Yellow ­ Parking Services, return to appellant with reply Pink - Appellant's initial copy PLEASE READ REVERSE SIDE SIMON FRASER UNIVERSITY PARKING SERVICES NOTICE OF APPEAL Section 1 - to be completed by Parking Services Date Appeal Received: ______________________________ Received by

  13. Overview of The Ariel Sharon (Ayalon) Park PARK ARIEL SHARON TEL AVIV METROPOLITAN GEM

    E-print Network

    Sadeh, Norman M.

    , the drainage and park design and programming were developed into an integrated master plan by a world classOverview of The Ariel Sharon (Ayalon) Park PARK ARIEL SHARON ­ TEL AVIV METROPOLITAN GEM The Ariel Sharon Park, a world class leading environmental project, was initiated by the Tel-Aviv District

  14. Welcome to Diamond Light Source Parking Visitors can park outside Diamond

    E-print Network

    Crowther, Paul

    Welcome to Diamond Light Source Parking ­ Visitors can park outside Diamond House, or if that is full, in the Visitor car park. Users should park around the ring. On Arrival ­ Diamond does not have 8500). Then take a seat 2 and wait for your Diamond contact to collect you. Users ­ Fast track users

  15. University of Aberdeen Car Parking Policy -v2 0.docx University of Aberdeen Car Parking Policy

    E-print Network

    Levi, Ran

    University of Aberdeen Car Parking Policy - v2 0.docx University of Aberdeen Car Parking Policy 1.0 Why have a car parking policy? The University of Aberdeen is aware of the importance of corporate. The University has developed to such an extent that its current car park capacity is not sufficient to provide

  16. Modeling Support for National Park Planning: Initial Results from Glacier National Park

    E-print Network

    Ford, Andrew

    1 Modeling Support for National Park Planning: Initial Results from Glacier National Park Andrew. The main case study simulates operational issues at Glacier National Park. The model simulates vehicles is used to show the simulated impacts from the park's shuttle system. The Glacier study demonstrates

  17. Parking Violation Policy Outline the policy regarding parking violations issued to operators in University of Michigan

    E-print Network

    Kirschner, Denise

    Parking Violation Policy Objective Outline the policy regarding parking violations issued. It is the responsibility of the vehicle operator to comply with all state and local parking ordinances. 2. It is the responsibility of the vehicle operator to secure the U-M vehicle when it is parked to deter theft or vandalism. 3

  18. Parking for admissions interviews The Office of Undergraduate Admissions has two parking

    E-print Network

    Yang, Eui-Hyeok

    Parking for admissions interviews The Office of Undergraduate Admissions has two parking spots next to the Howe Center that are reserved for admis- sions interview visitors. Please park in one of these spaces. If the admissions spaces are taken when you arrive, tempo- rarily park in front of the Howe Center and visit

  19. PARKING CHARGE NOTICE Swansea University operate a Car Parking Management Scheme which is administered by Total

    E-print Network

    Martin, Ralph R.

    PARKING CHARGE NOTICE Swansea University operate a Car Parking Management Scheme which is administered by Total Parking Solutions in order to control unauthorised vehicular access and inappropriate parking. Providing such control is essential to ensure that the campus functions safely and efficiently

  20. CrowdPark: A Crowdsourcing-based Parking Reservation System for Mobile Phones

    E-print Network

    Shenoy, Prashant

    , and braking behav- ior while circling has significant impact on automobile emissions [2]. Parking issues alsoCrowdPark: A Crowdsourcing-based Parking Reservation System for Mobile Phones Tingxin Yan§ , Baik. A reservation system that enables individuals to buy park- ing spots prior to leaving their home would

  1. Selected Parking Types Resident Parking,Permit Required

    E-print Network

    Lipson, Michal

    1 2 4 A B C ND ND WD WD WD SW SW ND FH FH FH ND/SC FH SC SC SC SC SC SC SC/B CAMPUS MAP NORTH,will be posted at www.parking.cornell.edu. FH,ND,SW,WD B,SC 1 - Hoy Road 4 - Campus Road 2 - Tower Road Info

  2. Everglades National Park Including Biscayne National Park. Activity Book.

    ERIC Educational Resources Information Center

    Ruehrwein, Dick

    Intended to help elementary school children learn about the resources of the Everglades and Biscayne National Parks, this activity book includes information, puzzles, games, and quizzes. The booklet deals with concepts related to: (1) the seasons; (2) fire ecology; (3) water; (4) fish; (5) mammals; (6) mosquitos; (7) birds; (8) venomous snakes;…

  3. Acadia National Park - Nature and Science

    NSDL National Science Digital Library

    This National Park Service (NPS) website highlights the natural resources of Acadia National Park. Resources discussed include animals (amphibians, birds and fish), plants (ferns, freshwater plants, grasses, mosses, liverworts and wildflowers), environmental factors (fire regime, pests, nonnative species, weather, water quality and air quality), and natural features of the park (beaches, coastline, forests, geologic formations, intertidal and subtidal zones, mountains, and wetlands). There are related documents about the park's air and water quality available to download.

  4. Geology Fieldnotes: Capitol Reef National Park, Utah

    NSDL National Science Digital Library

    This Capitol Reef National Park site contains park geology information, park maps, photographs, visitor information, and a teacher feature (resources for teaching geology with National Park examples). Geologic data includes descriptions of the Waterpocket Fold, a monocline formed in the Laramide Orogeny and made of sedimentary rock. Also covered is erosion, and details about the Cathedral Valley outcrop of gypsum. This formation is Permian to Cretaceous in age (270-80 million years old).

  5. Geology Fieldnotes: Grand Canyon National Park, Arizona

    NSDL National Science Digital Library

    Visitors can access park geology information, photographs, related links, visitor information, multimedia resources, and resources for teaching geology with National Park examples. The park geology section discusses the Grand Canyon's geologic history, structural geology, and features a question-and-answer section about the canyon. The history of the canyon as a park and environmental issues surrounding it are also discussed. A geologic cross section of the canyon showing the various rock layers is included.

  6. Geology Fieldnotes: Grand Teton National Park, Wyoming

    NSDL National Science Digital Library

    This National Park Service resource includes information about geology, park maps, visitor information, photographs, and links to other sites about this park. Geologic information spans the entire history of the park, beginning 2.5 billion years ago (Precambrian) to the present. Details about the different rock types and their formation, mountain building through plate tectonics and the Laramide Orogeny, formation of valleys and canyons, volcanism in the area, and erosion by glaciers are all covered.

  7. Nature and Science at Canyonlands National Park

    NSDL National Science Digital Library

    This National Park Service (NPS) website highlights the environment and ecosystems found in Canyonlands National Park. Topics include animals in the park (amphibians, reptiles, birds, fish and mammals), plant life (cacti, grasses, lichens, mosses, liverworts, trees, shrubs and wildflowers), environmental factors (air quality, invasive species, endangered fish, noise pollution, peregrine falcons and bighorn sheep), and natural features (deserts, pools, rivers and stream, geology). Links are provided to downloadable brochures and reports on park research activities and additional information on wildlife and plants.

  8. WF 070016 BERKELEY.EDU/TRANSPORTATION UC BERKELEY PARKING & TRANSPORTATION

    E-print Network

    Doudna, Jennifer A.

    available. Parking for Special Events must be pre-arranged and authorized by Parking & Transportation parking needs, staffing and service costs may be assessed. Making Special Event parking reservations WhenWF 070016 BERKELEY.EDU/TRANSPORTATION UC BERKELEY PARKING & TRANSPORTATION SPECIAL EVENT PARKING

  9. Tour of Park Geology: Hot Springs/Geothermal

    NSDL National Science Digital Library

    This National Park Service (NPS) site provides links to National Parks with hot springs or geothermal activity. Where appropriate, links are provided to geology, visitor information, photographs, park maps, multimedia resources, geologic research, and additional links. Parks at this site include Hot Springs National Park, Lassen Volcano National Park, and more.

  10. Queen's Parking Regulations for Motor Vehicles Message from the Manager

    E-print Network

    Graham, Nick

    Queen's Parking Regulations for Motor Vehicles Contents Message from the Manager Section 1 Definitions Section 2 Jurisdiction Section 3 Parking Permit Information Section 4 - Parking Areas and Parking Restrictions Section 5: Parking for Visitors and Guests to Campus Section 6 Motorcycle Parking Regulations

  11. KU Parking &Transit | 1501 Irving Hill Road | Lawrence, KS 66045 | (785) 864-PARK | Fax: (785) 864-5220 | parking.ku.edu | kupark@ku.edu 2014-2015 Parking Regulations

    E-print Network

    KU Parking &Transit | 1501 Irving Hill Road | Lawrence, KS 66045 | (785) 864-PARK | Fax: (785) 864-5220 | parking.ku.edu | kupark@ku.edu 2014-2015 Parking Regulations Page 1 Parking & Transit strives to provide for the University community and its visitors. The regulation of parking is a service to the university

  12. Cloning of the human IL13R?1 chain and reconstitution with the IL4R? of a functional IL4\\/IL13 receptor complex

    Microsoft Academic Search

    Brigitte Miloux; Patrick Laurent; Odile Bonnin; Jan Lupker; Daniel Caput; Natalio Vita; Pascual Ferrara

    1997-01-01

    The human homologue of the recently cloned murine IL-13 binding protein (IL-13R?1) was cloned from a cDNA library derived from the carcinoma cell line CAKI-1. The cloned cDNA encodes a 427 amino acid protein with two consensus patterns characteristic of the hematopoietic cytokine receptor family and a short cytoplasmic tail. The human protein is 74% identical to the murine IL-13R?1,

  13. IL-2 coordinates IL-2–producing and regulatory T cell interplay

    PubMed Central

    Amado, Inęs F.; Berges, Julien; Luther, Rita J.; Mailhé, Marie-Pierre; Garcia, Sylvie; Bandeira, Antonio; Weaver, Casey; Liston, Adrian

    2013-01-01

    Many species of bacteria use quorum sensing to sense the amount of secreted metabolites and to adapt their growth according to their population density. We asked whether similar mechanisms would operate in lymphocyte homeostasis. We investigated the regulation of the size of interleukin-2 (IL-2)–producing CD4+ T cell (IL-2p) pool using different IL-2 reporter mice. We found that in the absence of either IL-2 or regulatory CD4+ T (T reg) cells, the number of IL-2p cells increases. Administration of IL-2 decreases the number of cells of the IL-2p cell subset and, pertinently, abrogates their ability to produce IL-2 upon in vivo cognate stimulation, while increasing T reg cell numbers. We propose that control of the IL-2p cell numbers occurs via a quorum sensing–like feedback loop where the produced IL-2 is sensed by both the activated CD4+ T cell pool and by T reg cells, which reciprocally regulate cells of the IL-2p cell subset. In conclusion, IL-2 acts as a self-regulatory circuit integrating the homeostasis of activated and T reg cells as CD4+ T cells restrain their growth by monitoring IL-2 levels, thereby preventing uncontrolled responses and autoimmunity. PMID:24249704

  14. ASRC Report: Photovoltaic Covered Parking Lots

    E-print Network

    Perez, Richard R.

    ASRC Report: Photovoltaic Covered Parking Lots --- A Survey of Deployable Space In the Hudson River, parking lots represent an opportunity for the deployment of Photovoltaics (PV) on already built demand mitigation (2, 4.) At a time when technologies for parking lot deployment are being readied

  15. The planning of environmental logistics park

    Microsoft Academic Search

    Ping Guo; Desheng Zhang

    2010-01-01

    With the opening of China's efforts to increase, the service levels of logistics industry should be improved and more powerful logistics park should be built. Logistics park is important infrastructures to modern logistics industry, at present, logistics parks is land development hot issue own to its superiority on accumulative and radiation effect. For the railway as a less polluting in

  16. Performance Modeling of Intelligent Car Parking Systems

    E-print Network

    Telek, Miklós

    Performance Modeling of Intelligent Car Parking Systems K´aroly Farkas1,3 , G´abor Horv´ath1 Abstract. The performance analysis of the car parking process in a parking lot with various levels the average time necessary for the user to reach the desired destination, the amount of cars moving

  17. RESEARCH & OUTREACH CENTER AT UMORE PARK

    E-print Network

    Weiblen, George D

    ROSEMOUNT RESEARCH & OUTREACH CENTER AT UMORE PARK UNIVERSITY OF MINNESOTA ROSEMOUNT ROC OFFICE ROCK TRAIL TRAILHEAD ROSEMOUNT ROC AT UMORE PARK ROSEMOUNT ROC AT UMORE PARK ADMINISTRATIVE OFFICE AND CONFERENCE CENTER 1605 160TH ST. WEST - ROSEMOUNT, MN 55068 PHONE: 651.423.2455 FAX: 651.423.1491 WEB: www

  18. 78 FR 24323 - National Park Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ...Proclamation 8961 of April 19, 2013 National Park Week, 2013 By the President of the United States...to be passed on. During National Park Week, we celebrate the wonders entrusted to...summon us to experience it firsthand. This week, the National Park Service will make...

  19. Alluvial Fan, Rocky Mountain National Park

    USGS Multimedia Gallery

    The Alluvial Fan is a fan-shaped area of disturbance in Rocky Mountain National Park. It was created on July 15, 1982, when the earthen Lawn Lake Dam above the area gave way, flooding the Park and nearby town of Estes Park with more than 200 million gallons of water. Enormous boulders were displaced...

  20. Yellowstone National Park Online Slide File

    NSDL National Science Digital Library

    Yellowstone National Park

    This Yellowstone National Park website contains thousands of photographs of the Park. Images are organized by category including fire, thermal features, mammals, park structures, petrified trees, water, weather, scenics, and more. The photographs may be freely downloaded and more are being added through time.

  1. Metrics Report McMaster Parking Services

    E-print Network

    Hitchcock, Adam P.

    1 Metrics Report McMaster Parking Services Monthly Report September 2014 #12;2 MISSION STATEMENT Security & Parking Services strive to provide our University Community and visitors, with safe and well through information resources, polite and knowledgeable staff, and convenient parking facilities. We

  2. Lean thinking implementation at a safari park

    Microsoft Academic Search

    Denyse M. Julien; Benny Tjahjono

    2009-01-01

    Purpose – The purpose of this paper is to report on a research project at a safari park in Buckinghamshire, UK. The aim is to introduce lean principles to the park, to enable the park to increase profits through eliminating waste and improving the efficiency of key processes whilst concurrently increasing customer satisfaction. The research is based on a case

  3. UTS ACCESSIBLE PARKING PERMIT APPLICATION FOR STAFF

    E-print Network

    University of Technology, Sydney

    UTS ACCESSIBLE PARKING PERMIT APPLICATION FOR STAFF Accessible parking is available these parking spaces. Permits are issued to staff through the Equity and Diversity Unit, to students through, or is seriously compromised in their ability to use public transport to travel to the University (e.g. anxiety

  4. Geology Fieldnotes: Isle Royale National Park, Michigan

    NSDL National Science Digital Library

    This National Park Service (NPS) website examines the geology of Isle Royale National Park in Michigan. It looks at the geologic history of this archipelago, beginning 1.2 billion years ago and progressing through volcanics, rock formations and copper deposits, to the Ice Age. There are links to park maps, visitor information, and additional resources.

  5. Moon Park: A research and educational facility

    NASA Technical Reports Server (NTRS)

    Kuriki, Kyoichi; Saito, Takao; Ogawa, Yukimasa

    1992-01-01

    Moon Park has been proposed as an International Space Year (ISY) event for international cooperative efforts. Moon Park will serve as a terrestrial demonstration of a prototype lunar base and provide research and educational opportunities. The kind of data that can be obtained in the Moon Park facilities is examined taking the minimum number of lunar base residents as an example.

  6. 32 CFR 634.31 - Parking.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...2014-07-01 2013-07-01 true Parking. 634.31 Section 634.31 National... Traffic Supervision § 634.31 Parking. (a) The most efficient use of existing on- and off-street parking space should be stressed on a...

  7. PARKING COMMISSION MINUTES November 15, 2012

    E-print Network

    PARKING COMMISSION MINUTES November 15, 2012 Attendees: Steve Schrock, Andrew Shoemaker, Eddie parking permits, and the auto-gold list. With the planning for the renovation of Jayhawk Boulevard, the question of whether or not to remove parking spaces is under discussion again. In order to reduce

  8. 32 CFR 636.14 - Parking.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...2014-07-01 2013-07-01 true Parking. 636.14 Section 636.14 National... Fort Stewart, Georgia § 636.14 Parking. In addition to the requirements in... (a) Military Police will enforce parking in handicapped and Commanding...

  9. 15 CFR 265.17 - Parking permits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...2010-01-01 2010-01-01 false Parking permits. 265.17 Section 265.17...and Vehicular Regulations § 265.17 Parking permits. No person, except visitors...vehicle on the site without having a valid parking permit displayed on such motor...

  10. 15 CFR 265.17 - Parking permits.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...2011-01-01 2011-01-01 false Parking permits. 265.17 Section 265.17...and Vehicular Regulations § 265.17 Parking permits. No person, except visitors...vehicle on the site without having a valid parking permit displayed on such motor...

  11. Helen C. White Garage Visitor Parking

    E-print Network

    Sprott, Julien Clinton

    Helen C. White Garage Visitor Parking Effective Monday, April 8, 2013 Daytime and Evening visitor parking is "pay on exit". Visitors pull a ticket on entry and then pay at a Pay on Foot Station or at the exit lane column upon leaving. Visitor Parking available on Street Level: · All day, Sunday through

  12. 32 CFR 636.14 - Parking.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...2013-07-01 2013-07-01 false Parking. 636.14 Section 636.14 National... Fort Stewart, Georgia § 636.14 Parking. In addition to the requirements in... (a) Military Police will enforce parking in handicapped and Commanding...

  13. 15 CFR 265.16 - Parking.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...2013-01-01 2013-01-01 false Parking. 265.16 Section 265.16 Commerce...and Vehicular Regulations § 265.16 Parking. No person, unless otherwise authorized...would obstruct traffic; (h) In a parking space marked as not intended for his...

  14. 32 CFR 263.10 - Parking.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...2012-07-01 2012-07-01 false Parking. 263.10 Section 263.10 National...DEFENSE MAPPING AGENCY SITES § 263.10 Parking. (a) No person, unless otherwise...would obstruct traffic. (8) In a parking space marked as not intended for his...

  15. PARKING COMMISSION MINUTES March 5, 2013

    E-print Network

    PARKING COMMISSION MINUTES March 5, 2013 Attendees: Steve Schrock, Eddie Munoz, Margaret Mahoney). There was also discussion about the 50-year-contract for concession of Ohio State University parking parking software company, which will simplify and automate our ticket identification process. This changes

  16. 32 CFR 263.10 - Parking.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...2014-07-01 2014-07-01 false Parking. 263.10 Section 263.10 National...DEFENSE MAPPING AGENCY SITES § 263.10 Parking. (a) No person, unless otherwise...would obstruct traffic. (8) In a parking space marked as not intended for his...

  17. Parking Customer Services 523 S. Division

    E-print Network

    Kirschner, Denise

    Parking Customer Services 523 S. Division Ann Arbor, MI 48104-2912 Phone: (734) 764-8291 Fax: (734 daily Guest parking permit(s) to be charged to your department by SUB. This form must be used by all guest permits are for surface lots only. Prior authorization is required for access to structure parking

  18. 32 CFR 263.10 - Parking.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...2013-07-01 2013-07-01 false Parking. 263.10 Section 263.10 National...DEFENSE MAPPING AGENCY SITES § 263.10 Parking. (a) No person, unless otherwise...would obstruct traffic. (8) In a parking space marked as not intended for his...

  19. Parking Options 2011/12 Reserved Permits

    E-print Network

    Parking Options 2011/12 Reserved Permits A Reserved permit is $275 this fiscal year and is only available to faculty and staff through payroll deduction. Individuals issued a Reserved permit may park in any space in the lot they are assigned. Reserved parking will not be oversold, so if the lot

  20. Department of Public Safety Parking and

    E-print Network

    Dennett, Daniel

    Department of Public Safety Parking and Traffic Regulations SY 2012-2013 Edition Department of Public Safety Administrative Services 419 Boston Avenue Medford, MA 02155 (617) 627-3692 Visit http://publicsafety.tufts.edu/parking and to operate a motor vehicle on the streets, driveways and parking lots of the campus. 4. DEFINITIONS 4

  1. 32 CFR 636.14 - Parking.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...2012-07-01 2011-07-01 true Parking. 636.14 Section 636.14 National... Fort Stewart, Georgia § 636.14 Parking. In addition to the requirements in... (a) Military Police will enforce parking in handicapped and Commanding...

  2. PARKING COMMISSION MINUTES April 2, 2013

    E-print Network

    PARKING COMMISSION MINUTES April 2, 2013 Attendees: Steve Schrock, Eddie Munoz, Margaret Mahoney to apply to only 50 parking spaces and allow remainder to be "open" rest of the day, to allow overnight parking. Students who live close by have to get up to move their cars somewhere else, and possibly have

  3. Parking and Transportation Services ANNUAL REPORT

    E-print Network

    Yang, Zong-Liang

    Parking and Transportation Services ANNUAL REPORT October 2003 The University of Texas at Austin to present to you our Annual Report for September 1, 2002 to August 31, 2003 (FY 02-03). Parking to become the national leader of quality campus parking services that are customer focused, economically

  4. 15 CFR 265.17 - Parking permits.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...2014-01-01 2014-01-01 false Parking permits. 265.17 Section 265.17...and Vehicular Regulations § 265.17 Parking permits. No person, except visitors...vehicle on the site without having a valid parking permit displayed on such motor...

  5. 15 CFR 265.17 - Parking permits.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...2012-01-01 2012-01-01 false Parking permits. 265.17 Section 265.17...and Vehicular Regulations § 265.17 Parking permits. No person, except visitors...vehicle on the site without having a valid parking permit displayed on such motor...

  6. PARKING COMMISSION MINUTES November 29, 2012

    E-print Network

    PARKING COMMISSION MINUTES November 29, 2012 Attendees: Steve Schrock, Eddie Munoz, Margaret include a move to assigned parking and/or market-based pricing. Transit Kaiser said that there is not much to parking lots. These are big numbers because of other commitments that were decisions made outside of our

  7. 15 CFR 265.16 - Parking.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...2014-01-01 2014-01-01 false Parking. 265.16 Section 265.16 Commerce...and Vehicular Regulations § 265.16 Parking. No person, unless otherwise authorized...would obstruct traffic; (h) In a parking space marked as not intended for his...

  8. 15 CFR 265.16 - Parking.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...2012-01-01 2012-01-01 false Parking. 265.16 Section 265.16 Commerce...and Vehicular Regulations § 265.16 Parking. No person, unless otherwise authorized...would obstruct traffic; (h) In a parking space marked as not intended for his...

  9. 15 CFR 265.17 - Parking permits.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...2013-01-01 2013-01-01 false Parking permits. 265.17 Section 265.17...and Vehicular Regulations § 265.17 Parking permits. No person, except visitors...vehicle on the site without having a valid parking permit displayed on such motor...

  10. 15 CFR 265.16 - Parking.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...2011-01-01 2011-01-01 false Parking. 265.16 Section 265.16 Commerce...and Vehicular Regulations § 265.16 Parking. No person, unless otherwise authorized...would obstruct traffic; (h) In a parking space marked as not intended for his...

  11. 15 CFR 265.16 - Parking.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...2010-01-01 2010-01-01 false Parking. 265.16 Section 265.16 Commerce...and Vehicular Regulations § 265.16 Parking. No person, unless otherwise authorized...would obstruct traffic; (h) In a parking space marked as not intended for his...

  12. Student Parking at Pitt Helpful Hint

    E-print Network

    Sibille, Etienne

    Student Parking at Pitt Helpful Hint Evening students: Don't wait until the last minute to request your permit. The Parking Services Office can provide you with your permit well in advance of the first day of classes. Hours of Operation Monday­Friday 8:30 a.m.­5 p.m. Parking Services Office 204

  13. Parking Plus SBF 04/08/09 Application to withdraw from ParkingPlus.

    E-print Network

    Burton, Geoffrey R.

    Parking Plus SBF 04/08/09 Application to withdraw from ParkingPlus. As a current participant of the ParkingPlus scheme you have the right to opt out of the scheme at the point you renew your Parking Permit. Complete this form if you wish to OPT OUT of ParkingPlus for the year 2010/11 and send it to the Payroll

  14. The quandary of local people—Park relations in Nepal's Royal Chitwan National Park

    Microsoft Academic Search

    Karl E. Weber

    1995-01-01

    This paper analyzes five major causes of park-people conflicts that have occurred in Nepal's Royal Chitwan National Park.\\u000a The causes include illegal transactions of forest products from the park, livestock grazing in the park, illegal hunting and\\u000a fishing, crop damage, and threats to human and animal life caused by wild animals from the park. The conflicts indicate a\\u000a reciprocal relationship

  15. Exact and efficient calculation of Lagrange multipliers in constrained biological polymers: Proteins and nucleic acids as example cases

    E-print Network

    García-Risueńo, Pablo; Alonso, José Luis

    2011-01-01

    In order to accelerate molecular dynamics simulations, it is very common to impose holonomic constraints on their hardest degrees of freedom. In this way, the time step used to integrate the equations of motion can be increased, thus allowing, in principle, to reach longer total simulation times. The imposition of such constraints results in an aditional set of Nc equations (the equations of constraint) and unknowns (their associated Lagrange multipliers), that must be solved in one way or another at each time step of the dynamics. In this work it is shown that, due to the essentially linear structure of typical biological polymers, such as nucleic acids or proteins, the algebraic equations that need to be solved involve a matrix which is banded if the constraints are indexed in a clever way. This allows to obtain the Lagrange multipliers through a non-iterative procedure, which can be considered exact up to machine precision, and which takes O(Nc) operations, instead of the usual O(Nc3) for generic molecular...

  16. DIPLOSTOMOSIS IN NORTH PARK, COLORADO

    Microsoft Academic Search

    ROBERT B. DAVIES; WALTER T. BURKHARDE; CHARLES P. HIBLER

    1973-01-01

    The life cycle of Diplostoinuni spathaceuni (Rudobfi 1819), as it exists in North Park, Colorado, is elucidated. California gulls (Larus californicus), common mergansers (Mergus merganser) and Forster's terns (Sterna forsteri) act as definitive hosts. Two species of water snails, Phvsa gvrina and Lvnzneae elodes, act as first intermediate hosts with seven species of fish as second intermediate hosts: brassy minnows

  17. Violations & Enforcement Parking Violation Definitions

    E-print Network

    Hong, Jason I.

    zone Only authorized vehicles are allowed to actively load and unload in loading zones. · Parking for students who need to load or unload heavy equipment, projects or packages. · Failure to display hazard (flashing) lights while in a loading zone Vehicles must have hazard lights on while loading and unloading

  18. Staunton State Park Biological Inventory

    E-print Network

    Staunton State Park Biological Inventory Prepared by: Susan Spackman, David Anderson, Jeremy Biological Inventory Prepared by: Susan Spackman, David Anderson, Jeremy Siemers, Phyllis Pineda, and Jill. The information management staff with CNHP was responsible for integrating the data resulting from the inventory

  19. National Park Glaciers Knowledge Center

    NSDL National Science Digital Library

    2005-08-01

    This interactive resource explains what glaciers are, where they are found, how they form, and how they move. The types and parts of glaciers are discussed, as well as ice ages, the different types of landforms that may result from glaciation, and how scientists monitor glaciers. Examples from our national parks are also highlighted as case studies to illustrate how glaciers have created landscapes.

  20. 2010 TRANSPORTATION & PARKING SERVICES ACCOMPLISHMENTS

    E-print Network

    Mills, Allen P.

    subheadings such as Best Practice or Strategic Alliance to describe how we focused our actions toward Improvement Reduce/Recycle/Reuse Strategic Alliance Traffic control Training Trees #12;UC Riverside from remote wireless card-based parking dispensers. Lot 10 Pay By Space Quality Best Practice Processed

  1. UV - RESEARCH TRIANGLE PARK NC

    EPA Science Inventory

    Brewer 087 is located in Research Triangle Park NC, measuring ultraviolet solar radiation. Irradiance and column ozone are derived from this data. Ultraviolet solar radiation is measured with a Brewer Mark IV, single-monochrometer, spectrophotometer manufactured by SCI-TEC Instru...

  2. Visitor/Patient Parking Information

    E-print Network

    Portman, Douglas

    with locating your vehicle. If you are unable to locate your vehicle in the garage, please take the elevator/patients on each level of the garage, near the elevators. Upon request, Parking will provide jump starts, tire inflation and lock de-icer (free of charge). Lobby Automated Pay Stations (APS) Automatic Pay Stations

  3. Symmetry in the Car Park

    ERIC Educational Resources Information Center

    Hancock, Karen

    2007-01-01

    In this article, the author presents a lesson on rotational symmetry which she developed for her students. The aim of the lesson was "to identify objects with rotational symmetry in the staff car park" and the success criteria were "pictures or sketches of at least six objects with different orders of rotation". After finding examples of…

  4. HOURGLASS FIRE Pingree Park Vicinity

    E-print Network

    . Initial attack was conducted by personnel of the Arapaho-Roosevelt National Forest who arrived at the fire Forest Service and Larimer County had arrived on the scene along with crews from several local fire and resulting fire intensity, successful defensive fire suppression activities at the Pingree Park campus were

  5. National Zoological Park Branch Library.

    ERIC Educational Resources Information Center

    Kenyon, Kay A.

    1988-01-01

    Describes the functions of the National Zoological Park Branch of the Smithsonian Institution Libraries, which is dedicated to supporting the special information needs of the zoo. Topics covered include the library's history, collection, programs, services, future plans, and relations with other zoo libraries. (two references) (Author/CLB)

  6. IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation.

    PubMed

    French, Anthony R; Holroyd, Erika B; Yang, Liping; Kim, Sungjin; Yokoyama, Wayne M

    2006-09-01

    Mature natural killer (NK) cells are able to vigorously proliferate in response to infectious stimuli such as viral infections. The factors driving NK cell proliferation under these circumstances are only beginning to be characterized. NK cells constitutively express interleukin-18 receptor alpha and are stimulated by IL-18 to produce IFNgamma. Although IL-18 alone is not sufficient to drive NK cell proliferation, we demonstrate that IL-18 is able to act synergistically with IL-15 in stimulating in vitro NK cell proliferation. Furthermore using a NK cell line, we show that this effect occurs through direct stimulation of NK cells by IL-18 rather than through a secondary signal generated by an intermediary cell type. This raises the possibility that IL-18 may act synergistically with IL-15 in driving pathogen-induced NK cell proliferation in addition to its contribution in enhancing IL-12 stimulation of NK cell IFNgamma production. PMID:17052916

  7. The equations of Lagrange for a continuous deformable body with rigid body degrees of freedom, written in a momentum based formulation

    NASA Astrophysics Data System (ADS)

    Irschik, H.; Krommer, M.; Nader, M.; Vetyukov, Y.; von Garssen, H.-G.

    2015-01-01

    The present paper is concerned with Lagrange's Equations, applied to a deformable body in the presence of rigid body degrees of freedom. The Lagrange description of Continuum Mechanics is used. An exact version of the Equations is derived first. This version, which represents an identical extension of the Fundamental Law of Dynamics, does involve the idea of virtual motions. The virtual motion is described in the framework of the Ritz-Ansatz, but our derivation does not make use of D'Alemberts principle, the principle of virtual work, or variational principles. From the exact version, by involving arguments related to the Galerkin approximation technique, we derive an approximate Ritz type version of Lagrange's Equations. This approximate version coincides with the traditional one, which is based on the notion of kinetic energy. However, since our derivation stems from the Fundamental Law of Dynamics, we have at our disposal an alternative formulation, which is based on the notion of local momentum. This momentum based version, which is the main topic of the present contribution, can be used for the purpose of performing independent checks of the energy based version of Lagrange's Equations. The momentum based version also clarifies that and how certain terms in the energy based version do cancel out. The momentum based version is worked out in the framework of the Floating Frame of Reference Formulation of Multibody Dynamics. Explicit formulas for the single terms of Lagrange's Equations are derived for the translational, rotational and flexible degrees of freedom of the deformable body, respectively. Corresponding Lagrange's Equations are explained in the light of the relations of Balance of Total Momentum, Balance of Total Moment of Momentum, of the Mean Stress Theorem and the notion of Virial of Forces. An embedding into the literature is given.

  8. Association of Park Size, Distance, and Features With Physical Activity in Neighborhood Parks

    PubMed Central

    Kaczynski, Andrew T.; Potwarka, Luke R.; Saelens, Brian E.

    2008-01-01

    Objectives. We studied whether park size, number of features in the park, and distance to a park from participants’ homes were related to a park being used for physical activity. Methods. We collected observational data on 28 specific features from 33 parks. Adult residents in surrounding areas (n=380) completed 7-day physical activity logs that included the location of their activities. We used logistic regression to examine the relative importance of park size, features, and distance to participants’ homes in predicting whether a park was used for physical activity, with control for perceived neighborhood safety and aesthetics. Results. Parks with more features were more likely to be used for physical activity; size and distance were not significant predictors. Park facilities were more important than were park amenities. Of the park facilities, trails had the strongest relationship with park use for physical activity. Conclusions. Specific park features may have significant implications for park-based physical activity. Future research should explore these factors in diverse neighborhoods and diverse parks among both younger and older populations. PMID:18556600

  9. Inhibition of Keratinocyte Differentiation by the Synergistic Effect of IL-17A, IL-22, IL-1?, TNF? and Oncostatin M

    PubMed Central

    Rabeony, Hanitriniaina; Petit-Paris, Isabelle; Garnier, Julien; Barrault, Christine; Pedretti, Nathalie; Guilloteau, Karline; Jegou, Jean-François; Guillet, Gérard; Huguier, Vincent; Lecron, Jean-Claude; Bernard, François-Xavier; Morel, Franck

    2014-01-01

    Keratinocyte differentiation program leading to an organized epidermis plays a key role in maintaining the first line of defense of the skin. Epidermal integrity is regulated by a tight communication between keratinocytes and leucocytes, particularly under cytokine control. Imbalance of the cytokine network leads to inflammatory diseases such as psoriasis. Our attempt to model skin inflammation showed that the combination of IL-17A, IL-22, IL-1?, OSM and TNF? (Mix M5) synergistically increases chemokine and antimicrobial-peptide expression, recapitulating some features of psoriasis. Other characteristics of psoriasis are acanthosis and down-regulation of keratinocyte differentiation markers. Our aim was to characterize the specific roles of these cytokines on keratinocyte differentiation, and to compare with psoriatic lesion features. All cytokines decrease keratinocyte differentiation markers, but IL-22 and OSM were the most powerful, and the M5 strongly synergized the effects. In addition, IL-22 and OSM induced epidermal hyperplasia in vitro and M5 induced epidermal thickening and decreased differentiation marker expression in a mouse model, as observed in human psoriatic skin lesions. This study highlights the precise role of cytokines in the skin inflammatory response. IL-22 and OSM more specifically drive epidermal hyperplasia and differentiation loss while IL-1?, IL-17A and TNF? were more involved in the activation of innate immunity. PMID:25010647

  10. IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells

    PubMed Central

    Guenova, Emmanuella; Skabytska, Yuliya; Hoetzenecker, Wolfram; Sauer, Karin; Tham, Manuela; Kim, Kyu-Won; Park, Ji-Hyeon; Seo, Ji Hae; Ignatova, Desislava; Cozzio, Antonio; Levesque, Mitchell P.; Volz, Thomas; Köberle, Martin; Kaesler, Susanne; Thomas, Peter; Mailhammer, Reinhard; Ghoreschi, Kamran; Schäkel, Knut; Amarov, Boyko; Eichner, Martin; Schaller, Martin; Clark, Rachael A.; Röcken, Martin; Biedermann, Tilo

    2015-01-01

    Interleukin 4 (IL-4) can suppress delayed-type hypersensitivity reactions (DTHRs), including organ-specific autoimmune diseases in mice and humans. Despite the broadly documented antiinflammatory effect of IL-4, the underlying mode of action remains incompletely understood, as IL-4 also promotes IL-12 production by dendritic cells (DCs) and IFN-?–producing TH1 cells in vivo. Studying the impact of IL-4 on the polarization of human and mouse DCs, we found that IL-4 exerts opposing effects on the production of either IL-12 or IL-23. While promoting IL-12–producing capacity of DCs, IL-4 completely abrogates IL-23. Bone marrow chimeras proved that IL-4–mediated suppression of DTHRs relies on the signal transducer and activator of transcription 6 (STAT6)-dependent abrogation of IL-23 in antigen-presenting cells. Moreover, IL-4 therapy attenuated DTHRs by STAT6- and activating transcription factor 3 (ATF3)-dependent suppression of the IL-23/TH17 responses despite simultaneous enhancement of IL-12/TH1 responses. As IL-4 therapy also improves psoriasis in humans and suppresses IL-23/TH17 responses without blocking IL-12/TH1, selective IL-4–mediated IL-23/TH17 silencing is promising as treatment against harmful inflammation, while sparing the IL-12–dependent TH1 responses. PMID:25646481

  11. Inflammasome activation and IL1? and IL18 processing during infection

    Microsoft Academic Search

    Frank L. van de Veerdonk; Mihai G. Netea; Charles A. Dinarello; Leo A. B. Joosten

    2011-01-01

    Interleukin-1beta (IL-1beta) and IL-18 contribute to host defense against infection by augmenting antimicrobial properties of phagocytes and initiating Th1 and Th17 adaptive immune responses. Protein complexes called inflammasomes activate intracellular caspase-1 autocatalytically, which cleaves the inactive precursors of IL-1beta and IL-18 into bioactive cytokines. In this review, we discuss the controversies regarding inflammasome activation and the role of the inflammasome

  12. Association analysis of IL12B and IL23R polymorphisms in myocardial infarction

    Microsoft Academic Search

    Massimo Mangino; Peter Braund; Ravi Singh; Richard Steeds; Suzanne Stevens; Kevin S Channer; Nilesh J Samani

    2008-01-01

    The notion that coronary atherosclerosis and its most severe phenotype, myocardial infarction (MI), are chronic inflammatory\\u000a diseases is supported by several lines of evidence. Interleukins (ILs) are important mediators and modulators of inflammation.\\u000a Specific polymorphisms in the genes encoding subunits of IL-23 (IL-12B) and its receptor (IL-23R) have recently been consistently found to be associated with chronic immune-mediated diseases. In

  13. IL1 Receptor Antagonist (IL1RA) Gene Polymorphism in Sjogren's Syndrome and Rheumatoid Arthritis

    Microsoft Academic Search

    S. Perrier; C. Coussediere; J. J. Dubost; E. Albuisson; B. Sauvezie

    1998-01-01

    The gene encoding interleukin-1 receptor antagonist (IL-1ra) has a variable allelic polymorphism. The IL1RN*2 allele was recently described as a factor of severity in several autoimmune diseases and was paradoxically associated with increased production of IL-1ra by monocytesin vitro.We studied this polymorphism in 36 patients with possible or definite primary Sjogren's syndrome and found that IL1RN*2 was significantly more frequent

  14. IL-33: A Sheep in Wolf's Clothing?

    NSDL National Science Digital Library

    Massimo Gadina (Queen's University Belfast; Centre for Cancer Research and Cell Biology REV)

    2007-06-12

    Cytokines are soluble factors that regulate intercellular communication by binding to specific cell-surface receptors and activating cellular responses. A small subset of cytokines, however, has been recognized to act in an intracrine manner without being secreted. These molecules enter the nucleus and regulate gene transcription by binding nuclear coactivators or repressors. Interleukin-33 (IL-33), a cytokine with high sequence and structural similarity to IL-1 and IL-18, has now been identified as another member of this group of "double agents." The activity of IL-33, however, appears to be the opposite of other dual-activity molecules such as the proinflammatory molecules, IL-1? and HMBG1 (high-mobility group box 1). Soluble IL-33 binds the Toll-interleukin 1 (IL-1) receptor (TIR) domain-containing receptor ST2 and has T helper 2 (Th2) immunoregulatory activity. ST2 also inhibits the activity of Toll-like receptors (TLRs) by sequestering the TLR adaptor molecules MyD88 and Mal. The HMBG1 receptor pairs with TLRs and helps drive responses to infections, raising the possibility that ST2, acting as a coreceptor for TLRs, could modulate and perhaps limit immune responses to pathogens. The nuclear targets of IL-33 are still unknown, but the expression of IL-33 in inflamed tissues, its nuclear repressor activity, and the antagonistic properties of ST2 suggest that it could decrease inflammation, opposing the activity of factors like IL-1. If this holds true, IL-33 has potential as a novel therapeutic in autoimmune and inflammatory diseases.

  15. Il ruolo delle nuove tecnologie ICT nei trasporti marittimi passeggeri: il mercato crocieristico

    Microsoft Academic Search

    Sara Canevello; Alberto Cappato

    1. Il peso economico ed il ruolo delle nuove tecnologie nel settore del turismo e dei trasporti Il settore turistico e dei trasporti, com'č noto, basa la propria efficacia sulla capacitŕ di reperire e divulgare, tra tutti i soggetti della filiera, informazioni al fine di ottimizzare le diverse combinazioni tra domanda e offerta. Tali operazioni sono facilitate dalle applicazioni integrate

  16. Procedure for Managing Account Information at Parking Online 1. Go to Parking Services webpage at http://www.uaf.edu/parking.

    E-print Network

    Ickert-Bond, Steffi

    Procedure for Managing Account Information at Parking Online 1. Go to Parking Services webpage at http://www.uaf.edu/parking. 2. Select Manage My Account under the Parking Online Logo. 3. Select Manage My Parking Account from the Menu. 4. Log in by using your Network, Google mail or Black Board account

  17. Parks as a tool for HIV management.

    PubMed

    Shacham, Enbal; Hipp, J Aaron; Scheuermann, Mary; Önen, Nur; Overton, E Turner

    2015-01-01

    Access to parks improves overall health outcomes in the general population. Given that HIV infection has become a chronic disease to manage, among populations engaged in medical care, parks may be promoted as physical activity opportunities in order to manage chronic comorbid conditions. We conducted a cross-sectional examination of the relationships between sociodemographic and biomedical characteristics to park proximity among 635 individuals receiving outpatient HIV care. The data collected included HIV-related biomarkers, depression, and diagnoses of other chronic diseases. The total acres of parks an individual is exposed within one-quarter mile from their home were assessed. The cohort included 635 individuals (67% men, 73% black, and 21% white, mean age 42 years). Unemployment was negatively associated with park availability. Park proximity was not associated with depression or HIV biomarkers. As yet, little effort has been committed to promoting park usage as a low-cost, sustainable method to addressing comorbidities among individuals with HIV. PMID:23995296

  18. Wild pig populations in the National Parks

    NASA Astrophysics Data System (ADS)

    Singer, Francis J.

    1981-05-01

    Populations of introduced European wild boar, feral pigs, and combinations of both types (all Sus scrola L.) inhabit thirteen areas in the National Park Service system. All parks have relatively stable populations, with the exception of Great Smoky Mountains National Park, which reported a rapidly expanding wild boar population. Suspected and documented impacts were apparently related to pig densities and sensitivity of the ecosystem; the three largest units with dense wild pig populations reported the most damage. Overall, wild pigs are a relatively minor problem for the Park Service; however, problems are severe in at least three parks, and there is potential for invasion of wild boars into several additional parks in the Appalachian Mountains. More specific information is needed on numbers of wild pigs and their impacts in the various parks.

  19. Species in Parks: Flora and Fauna Database

    NSDL National Science Digital Library

    1997-01-01

    The Information Center of the Environment and the US National Park Service (NPS) have developed a "preliminary" data base of vascular plants and vertebrates located on National Park Service Lands. Although the database is not a complete list of species residing on NPS lands, it contains relatively complete lists for both small and large parks. Users can search for plants and animals by species or park name. Within each park, one can search a list of species by taxa (e.g., birds, mammals, fish, etc.) and then learn in what other parks that species is found. Links to the home pages for all NPS property (from American Samoa to Zion National Park) are featured. Both plant and animal databases are available for downloading for Windows or DOS users (.exe).

  20. Multispectral Imaging Using Multiplexed Illumination Jong-Il Park, Moon-Hyun Lee, Michael D. Grossberg

    E-print Network

    Nayar, Shree K.

    an illumination source with rapidly changing spectra than a camera with rapidly changing spectral sensitivity with a minor increase in system complexity. Varying either the spectral sensitivity of the camera multiple spectral sources and a multispectral camera. We have implemented a system based on this approach

  1. IL-1 blockade in autoinflammatory syndromes.

    PubMed

    Jesus, Adriana A; Goldbach-Mansky, Raphaela

    2014-01-01

    Monogenic autoinflammatory syndromes present with excessive systemic inflammation including fever, rashes, arthritis, and organ-specific inflammation and are caused by defects in single genes encoding proteins that regulate innate inflammatory pathways. Pathogenic variants in two interleukin-1 (IL-1)-regulating genes, NLRP3 and IL1RN, cause two severe and early-onset autoinflammatory syndromes, CAPS (cryopyrin associated periodic syndromes) and DIRA (deficiency of IL-1 receptor antagonist). The discovery of the mutations that cause CAPS and DIRA led to clinical and basic research that uncovered the key role of IL-1 in an extended spectrum of immune dysregulatory conditions. NLRP3 encodes cryopyrin, an intracellular "molecular sensor" that forms a multimolecular platform, the NLRP3 inflammasome, which links "danger recognition" to the activation of the proinflammatory cytokine IL-1?. The success and safety profile of drugs targeting IL -1 in the treatment of CAPS and DIRA have encouraged their wider use in other autoinflammatory syndromes including the classic hereditary periodic fever syndromes (familial Mediterranean fever, TNF receptor-associated periodic syndrome, and hyperimmunoglobulinemia D with periodic fever syndrome) and additional immune dysregulatory conditions that are not genetically well defined, including Still's, Behcet's, and Schnitzler diseases. The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1?-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease. PMID:24422572

  2. Bacterial taxonomic tree Il codice genetico

    E-print Network

    Morante, Silvia

    , il seminatore, tiene con cura le ruote. #12;Codice genetico Non-palindrome #12;Il codice genetico Vedi uso triplette #12;#12;Teoricamente 46 = 4096 diverse 6-plette 43 = 64 diverse 6-plette palindrome Di tutte le possibili 6-plette ~15% palindrome Siti di attacco enzimi restrizione da 4 a 8 basi 6

  3. IL-2: Change Structure … Change Function.

    PubMed

    Bluestone, Jeffrey A; Crellin, Natasha; Trotta, Eleonora

    2015-05-19

    In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences. PMID:25992850

  4. Mouse bone marrow-derived IL-3-dependent mast cells and autonomous sublines produce IL-6.

    PubMed

    Hültner, L; Szöts, H; Welle, M; Van Snick, J; Moeller, J; Dörmer, P

    1989-07-01

    This study deals with the question of whether mouse bone marrow-derived mast cells are able to produce interleukin-6 (IL-6) in vitro. For this purpose, a panel of primary mast cell clones from limiting-dilution microcultures, of permanent IL-3-dependent mast cell lines and autonomous malignant sublines, was screened. All of these lines were found to produce growth factor activity for IL-6-dependent mouse hybridoma cells (7TD1), which could be completely neutralized by the monoclonal anti-IL-6-antibody 6B4. Transcriptional activity of the IL-6 gene was demonstrated in both IL-3-dependent mast cells and autonomous sublines using a mouse IL-6-specific cDNA probe. PMID:2788129

  5. Mouse bone marrow-derived IL-3-dependent mast cells and autonomous sublines produce IL-6.

    PubMed Central

    Hültner, L; Szöts, H; Welle, M; Van Snick, J; Moeller, J; Dörmer, P

    1989-01-01

    This study deals with the question of whether mouse bone marrow-derived mast cells are able to produce interleukin-6 (IL-6) in vitro. For this purpose, a panel of primary mast cell clones from limiting-dilution microcultures, of permanent IL-3-dependent mast cell lines and autonomous malignant sublines, was screened. All of these lines were found to produce growth factor activity for IL-6-dependent mouse hybridoma cells (7TD1), which could be completely neutralized by the monoclonal anti-IL-6-antibody 6B4. Transcriptional activity of the IL-6 gene was demonstrated in both IL-3-dependent mast cells and autonomous sublines using a mouse IL-6-specific cDNA probe. Images Figure 5 PMID:2788129

  6. Oregon State Parks and Recreation

    NSDL National Science Digital Library

    What can you do in the great Oregon outdoors? From the world of Cannon Beach to the wild and rugged Snake River, the experiences are diverse, to say the least. The homepage features dramatic vistas, isolated lighthouses, and a whole range of wonderful images to entice visitors. In the Visit area, there is an interactive map of the state that will help plan any trip. Here visitors can select Activities and Facilities to look for specific amenities. Moving along, the Event Calendar area allows visitors to look for upcoming events at a specific park or by category. Policy folks will appreciate the About Us area, as it includes detailed information on the Oregon Parks and Recreation Department's budget, their annual report, information about upcoming initiatives, and construction projects.

  7. Hyde Park Herald Digital Collections

    NSDL National Science Digital Library

    Hyde Park is a well-known urban neighborhood eight miles south of Chicago's Loop, and residents in and around the neighborhood have a long tradition of independent journalism. The Hyde Park Herald was started in 1882, and it documented the community's earliest history, including the years before the neighborhood was annexed to Chicago. Recently, a group of concerned citizens donated money to digitize the newspaper's back issues, and it was done to celebrate the leadership of Bruce Sagan, who has published the newspaper since 1953. Visitors can view the newspaper from 1882 to the present day, and despite a gap between the years 1889 and 1918, the coverage is quite good. Some good starting points include the WWII years and the late 1950s, which was when the first urban renewal project started in the neighborhood. Also, visitors may wish to perform a detailed search across the entire collection and then can also learn a bit more about the paper's history here.

  8. The Bronx Park Postcard Collection

    NSDL National Science Digital Library

    Over the years since its origins in the late 1880s, the Bronx Park has been expanded several times. In 1891, the city of New York allotted 250 acres of the park to the New York Botanical Garden, and in 1897 assigned 250 more to the Bronx Zoo. This particular digital collection brings together postcards of the grounds held by the Wildlife Conservation Society Library and the Garden's LuEsther T. Mertz Library. The collection here includes over 450 postcards, which visitors can browse by subject headings, including Zoo animals, Paths and walkways, and Bronx River. The Zoo animals area is well worth a look, as it features a range of animals, including a Noah's Ark exhibit, camels, and Indian elephants. It's an amazing archive of documents related to one of the most famous zoos in the United States, and historians and others will find it quite marvelous.

  9. The Parkes Pulsar Timing Array

    E-print Network

    R N Manchester

    2006-04-13

    Given sufficient sensitivity, pulsar timing observations can make a direct detection of gravitational waves passing over the Earth. Pulsar timing is most sensitive to gravitational waves with frequencies in the nanoHertz region, with the most likely astronomical sources being binary super-massive black holes in galaxy cores. The Parkes Pulsar Timing Array project uses the Parkes 64-m radio telescope to make precision timing observations of a sample of about 20 millisecond pulsars with a principal goal of making a direct detection of gravitational waves. Observations commenced about one year ago and so far sub-microsecond timing residuals have been achieved for more than half of these pulsars. New receiver and software systems are being developed with the aim of reducing these residuals to the level believed necessary for a positive detection of gravitational waves.

  10. National Association for Olmsted Parks

    NSDL National Science Digital Library

    Established in 1980, the National Association for Olmsted Parks (NAOP) is a coalition of various design and preservation professionals concerned with the legacy of landscape work left by noted landscape designer Frederick Law Olmsted Sr. and his colleagues. On their website, visitors can learn about Olmsted's primary works via a master list of design projects by his firm and some profiles of some of his most prominent work, including Central Park and the landscape at the Biltmore Estate. Scholars will want to look through the "Research" area for resources that include a set of suggested links and an extensive bibliography. Visitors will also want to look at the "News and Publications" area for more details about the NAOP's work and their newsletter.

  11. The Potential for Pocket Parks to Increase Physical Activity

    PubMed Central

    Cohen, Deborah A.; Marsh, Terry; Williamson, Stephanie; Han, Bing; Derose, Kathryn Pitkin; Golinelli, Daniella; McKenzie, Thomas L.

    2014-01-01

    Purpose To assess the use of new pocket parks in low-income neighborhoods. Setting Los Angeles Subjects Parks users and residents living within ˝ mile of 3 pocket parks and 15 neighborhood parks Intervention The creation of pocket parks Design Quasi-experimental post-only comparison Measures We used the System of Observing Play and Recreation in Communities (SOPARC) to measure park use and park-based physical activity and surveyed park users and residents about their park use. Analysis We surveyed 392 and 432 household members within one-half mile of the 3 pocket parks before and after park construction, respectively, as well as 71 pocket park users and compared them to 992 neighborhood park users and 342 residents living within ˝ mile of other neighborhood parks. We compared pocket park use to playground area use in the larger neighborhood parks. We used descriptive statistics and Generalized Estimating Equations for the analysis. Results Overall, pocket park use compared favorably in promoting moderate-to-vigorous physical activity with that of existing playground space in nearby parks and they were cost-effective at $0.73/MET hour gained. Pocket park visitors walked an average of 0.25 miles to get there. Conclusions Pocket parks, when perceived as attractive and safe destinations, may increase physical activity by encouraging families with children to walk there. Additional strategies and programs may be needed to encourage more residents to use the parks. PMID:24380461

  12. Competition of IL-1 and IL-1ra determines lymphocyte response to delayed stimulation with PHA.

    PubMed Central

    Dabrowski, M P; Stankiewicz, W; P?usa, T; Chcia?owski, A; Szmigielski, S

    2001-01-01

    BACKGROUND: Human peripheral blood mononuclear cells (PBMC) left in microcultures for 24h without mitogen do not respond to subsequent stimulation with PHA. They regain reactivity if the native culture medium is absorbed with other party lymphocytes or partially replaced with the medium from a PHA-stimulated culture. The observations suggest that, during the incubation, some inhibitory agent had accumulated in the culture medium. AIM: The study was performed to determine the nature of the observed phenomenon in respect of the possible role of monocytes and their products IL-1 and IL-1 receptor antagonist (IL-1ra), and to test for immunodiagnostic purposes the significance of quantifying the lymphocyte response to delayed stimulation with PHA in patients suffering from inflammatory prosesses. METHODS: Lymphocyte response to delayed stimulation with PHA, calculated as the lymphocyte-monokine interaction (LM) index, was determined in the microcultures of PBMC isolated from the blood of healthy donors or of patients with acute tonsilitis. The values of LM indices were compared with the ratios of IL-1ra/IL-1beta concentration estimated by enzyme-linked immunosorbent assay method in the culture supernatants. The influences of exogenous IL-1beta, IL-1ra, anti-IL1ra antibodies and antibiotic cefaclor on the monokine concentrations and on the values of LM index were tested. RESULTS AND CONCLUSIONS: The results show that the level of lymphocyte response to delayed stimulation with PHA (LM index) is inversely proportional to the ratio of IL-1ra/IL-1beta concentration in the culture. The low LM values at high IL-1ra/IL-1beta ratios in PBMC cultures from healthy donors, reversed proportions found in patients' PBMC (acute tonsilitis), and the cefaclor-induced reduction of LM value with correlated increase of the IL-1ra/IL-1beta ratio suggest that the LM assay may prove to be useful for immunodiagnostic purposes. PMID:11545246

  13. Production of interleukin (IL)-6 and IL-8 by a choriocarcinoma cell line, BeWo.

    PubMed

    Fujisawa, K; Nasu, K; Arima, K; Sugano, T; Narahara, H; Miyakawa, I

    2000-05-01

    To clarify the biological and pathological features of choriocarcinoma, we evaluated the in vitro production of cytokines by a choriocarcinoma cell line, BeWo. We measured the concentration of interleukin (IL)-6 and IL-8 in the culture media of BeWo cells after stimulation with various modulatory agents of cytokine expression by enzyme-linked immunosorbent assays. Northern blot analysis was used to examine the expression of IL-6 and IL-8 mRNA in these cells. A weak expression of IL-6 and IL-8 was detected in unstimulated BeWo cells by both methods. IL-6 transcription and secretion were dose-dependently enhanced by stimulation with IL-1beta, tumour necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta1 and 12-O-tetradecanoyl phorbol-13-acetate (TPA). Forskolin, lipopolysaccharide and interferon-gamma had no effect on these cytokines production. The TNF-alpha-induced secretion of IL-6 was inhibited by dexamethasone. The TPA-induced production of IL-6 was inhibited by 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine and sphyngosine, suggesting the involvement of a protein kinase C-dependent pathway. Levels of IL-8 mRNA and protein were also dose-dependently increased by stimulation with IL-1beta, TNF-alpha and TPA. In contrast to IL-6, the expression of IL-8 was not affected by TGF-beta1. It is suggested that, in addition to the production of steroidal and non-steroidal hormones, these cytokines may serve as part of a cytokine network that modulates the proliferation and angiogenesis of choriocarcinomas. PMID:10833370

  14. Anti-IL-5 Therapy Reduces Mast Cells and IL-9 Cells in Pediatric Eosinophilic Esophagitis

    PubMed Central

    Otani, Iris M.; Anilkumar, A. Andrew; Newbury, Robert O.; Bhagat, Monica; Beppu, Lisa Y.; Dohil, Ranjan; Broide, David H.; Aceves, Seema S.

    2013-01-01

    Background Eosinophilic esophagitis (EoE) is a clinicopathologic entity of increasing worldwide prevalence. IL-5 is essential for eosinophil trafficking and anti-IL-5 therapy decreases esophageal eosinophilia. EoE is associated with a prominent mast cell infiltration. Objective We investigated whether anti-IL-5 (mepolizumab) treatment reduced esophageal mast cell accumulation in pediatric EoE biopsy specimens from a previous randomized anti-IL-5 trial. Methods A sub-analysis was completed for children treated with 0.55, 2.5, or 10mg/kg of mepolizumab monthly for 12 weeks followed by no treatment until week 24. Quantitative immunochemistry was used to assess eosinophils, tryptase-positive mast cells, IL-9+ cells, and mast cell-eosinophil couplets prior to and following treatment. Results 43 patient biopsies had adequate tissue for paired analysis. 40% of subjects responded to anti-IL-5 (defined as <15 eosinophils per hpf following mepolizumab therapy) and 77% of all subjects had decreased numbers of mast cells following anti-IL-5. In responders, epithelial mast cells decreased from 62 to 19 per hpf (p<0.001), were significantly lower than in non-responders following therapy (p<0.05), and correlated with eosinophil numbers (r=0.75, p<0.0001). Mast cells and eosinophils were found in couplets prior to therapy and these were significantly decreased only in responders following anti-IL-5 (p<0.001). Esophageal eosinophils comprised the majority of cells that made the mast cell growth factor IL-9. IL-9+ cells decreased from 102 to 71 per hpf (p<0.001) following anti-IL-5. Conclusions Pediatric EoE patients had significantly fewer mast cells, IL-9+ cells, and mast cell-eosinophil couplets in the esophageal epithelium following anti-IL-5 therapy. Since eosinophils were one source of IL-9, they may support esophageal mastocytosis. PMID:23623266

  15. Yellowstone National Park Online Tours

    NSDL National Science Digital Library

    Yellowstone National Park

    This Yellowstone National Park website provides an array of online tours, videos, and other information. Nature and history tours are among those featured on the site. The nature tours cover the Old Faithful area, the Norris Geyser Basin, the Fountain Paint Pots, the Mammoth Hot Springs, and the Grand Canyon of the Yellowstone. Each of these tours highlights prominent natural features with photos and descriptions.

  16. PROC. OF 7TH INTL. SYMPOSIUM ON MODELING AND OPTIMIZATION IN MOBILE, AD HOC, AND WIRELESS NETWORKS (WIOPT), JUNE 2009 1 Delay Reduction via Lagrange Multipliers in

    E-print Network

    Neely, Michael J.

    . This role can be viewed as the counterpart of the "shadow price" role of Lagrange Multipliers in flow@usc.edu) and Michael J. Neely (web: http://www-rcf.usc.edu/mjneely) are with the Department of Electrical En- gineering

  17. Decreto n. 4745 IL RETTORE dipartimento risorse umane e organizzazione

    E-print Network

    Malerba, Donato

    -amministrativo del Dipartimento di " Farmacia "; D E C R E T A 1. E' costituito il Consiglio del Dipartimento di "Farmacia ". 2. Per il triennio accademico 2012/2015, il Consiglio del Dipartimento di cui all'art. 1 č

  18. Woofer-tweeter adaptive optics scanning laser ophthalmoscopic imaging based on Lagrange-multiplier damped least-squares algorithm

    PubMed Central

    Zou, Weiyao; Qi, Xiaofeng; Burns, Stephen A.

    2011-01-01

    We implemented a Lagrange-multiplier (LM)-based damped least-squares (DLS) control algorithm in a woofer-tweeter dual deformable-mirror (DM) adaptive optics scanning laser ophthalmoscope (AOSLO). The algorithm uses data from a single Shack-Hartmann wavefront sensor to simultaneously correct large-amplitude low-order aberrations by a woofer DM and small-amplitude higher-order aberrations by a tweeter DM. We measured the in vivo performance of high resolution retinal imaging with the dual DM AOSLO. We compared the simultaneous LM-based DLS dual DM controller with both single DM controller, and a successive dual DM controller. We evaluated performance using both wavefront (RMS) and image quality metrics including brightness and power spectrum. The simultaneous LM-based dual DM AO can consistently provide near diffraction-limited in vivo routine imaging of human retina. PMID:21750774

  19. Analysis of complex elastic structures by a Rayleigh-Ritz component modes method using Lagrange multipliers. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Klein, L. R.

    1974-01-01

    The free vibrations of elastic structures of arbitrary complexity were analyzed in terms of their component modes. The method was based upon the use of the normal unconstrained modes of the components in a Rayleigh-Ritz analysis. The continuity conditions were enforced by means of Lagrange Multipliers. Examples of the structures considered are: (1) beams with nonuniform properties; (2) airplane structures with high or low aspect ratio lifting surface components; (3) the oblique wing airplane; and (4) plate structures. The method was also applied to the analysis of modal damping of linear elastic structures. Convergence of the method versus the number of modes per component and/or the number of components is discussed and compared to more conventional approaches, ad-hoc methods, and experimental results.

  20. Science Enabled by the Ares V: A Large Monolithic Telescope Placed at the Second Sun-Earth Lagrange Point

    NASA Technical Reports Server (NTRS)

    Hopkins, Randall C.; Stahl, H. Philip

    2007-01-01

    The payload mass and volume capabilities of the planned Ares V launch vehicle provide the science community with unprecedented opportunities to place large science payloads into low earth orbit and beyond. One example, the outcome of a recent study conducted at the NASA Marshall Space Flight Center, is a large, monolithic telescope with a primary mirror diameter of 6.2 meters placed into a halo orbit about the second Sun-Earth Lagrange point, or L2, approximately 1.5 million kin beyond Earth's orbit. Operating in the visible and ultraviolet regions of the electromagnetic spectrum, such a large telescope would allow astronomers to detect bio-signatures and characterize the atmospheres of transiting exoplanets, provide high resolution imaging three or more times better than the Hubble Space Telescope and the James Webb Space Telescope, and observe the ultraviolet light from warm baryonic matter.

  1. Prediction of IL4 Inducing Peptides

    PubMed Central

    Gupta, Sudheer; Raghava, G. P. S.

    2013-01-01

    The secretion of Interleukin-4 (IL4) is the characteristic of T-helper 2 responses. IL4 is a cytokine produced by CD4+ T cells in response to helminthes and other extracellular parasites. It has a critical role in guiding antibody class switching, hematopoiesis and inflammation, and the development of appropriate effector T-cell responses. In this study, it is the first time an attempt has been made to understand whether it is possible to predict IL4 inducing peptides. The data set used in this study comprises 904 experimentally validated IL4 inducing and 742 noninducing MHC class II binders. Our analysis revealed that certain types of residues are preferred at certain positions in IL4 inducing peptides. It was also observed that IL4 inducing and noninducing epitopes differ in compositional and motif pattern. Based on our analysis we developed classification models where the hybrid method of amino acid pairs and motif information performed the best with maximum accuracy of 75.76% and MCC of 0.51. These results indicate that it is possible to predict IL4 inducing peptides with reasonable precession. These models would be useful in designing the peptides that may induce desired Th2 response. PMID:24489573

  2. Extracorporeal photopheresis promotes IL-1? production.

    PubMed

    Yakut, Erhan; Jakobs, Christopher; Peric, Adriana; Michel, Gabriela; Baal, Nelli; Bein, Gregor; Brüne, Bernhard; Hornung, Veit; Hackstein, Holger

    2015-03-15

    Extracorporeal photopheresis (ECP) is a widely used clinical cell-based therapy exhibiting efficacy in heterogenous immune-mediated diseases such as cutaneous T cell lymphoma, graft-versus-host disease, and organ allograft rejection. Despite its documented efficacy in cancer immunotherapy, little is known regarding the induction of immunostimulatory mediators by ECP. In this article, we show that ECP promotes marked release of the prototypic immunostimulatory cytokine IL-1?. ECP primes IL-1? production and activates IL-1? maturation and release in the context of caspase-1 activation in monocytes and myeloid dendritic cells. Of interest, IL-1? maturation by ECP was fully intact in murine cells deficient in caspase-1, suggesting the predominance of an inflammasome-independent pathway for ECP-dependent IL-1? maturation. Clinically, patient analysis revealed significantly increased IL-1? production in stimulated leukapheresis concentrates and peripheral blood samples after ECP. Collectively, these results provide evidence for promotion of IL-1? production by ECP and offer new insight into the immunostimulatory capacity of ECP. PMID:25681340

  3. The Lagrange Street story: the prevention of aromatics air pollution during the last nine years in a European city

    NASA Astrophysics Data System (ADS)

    Bono, Roberto; Bugliosi, Elva H.; Schilirň, Tiziana; Gilli, Giorgio

    Benzene, toluene and xylenes (BTX) air pollution is a very important topic for environmental health, due to the toxicity and/or mutagenetic or carcinogenetic properties of these aromatics and the commercialisation of the unleaded gasoline containing amount of BTX. We measured BTX in the air of Turin city, the capital of Piedmont region (north-western Italy), during 10 years, from 1989 to 1998. The sampling site selected was Lagrange Street (LS), an "urban canyon" placed in the centre of the city. The behaviour of BTX in LS was conditioned by some local and national legislative measures enforced during 1990s for the reduction of automotive traffic and BTX air pollution, respectively. Taking into account the existence of similar measures undertaken also in several cities in the developed countries, largely described but never discussed, the aim of this study was to verify in LS the preventive effects of these regulatory actions by means of a longitudinal survey extended over 10 years. Results obtained in Lagrange Street highlight seasonal trends, typical of this kind of pollutants, and an important reduction (from 42.6 to 15.9 ppbv) of aromatic hydrocarbons (sum of benzene, toluene and xylenes) in atmospheric air from 1990 to 1997. In particular, the annual level of benzene in air showed a mean from 9.2 ppbv in 1990 to 2.0 ppbv in 1997, almost half of the 3.1 ppbv imposed by law since 31 December 1998. In conclusion, the present findings induce a consistent optimism about the usefulness and the effectiveness of these types of regulatory actions enforced to reduce the human exposure to BTX, which could be extended also to other trafficated sites where the aromatics air pollution has to be reduced.

  4. Geology Fieldnotes: Theodore Roosevelt National Park, North Dakota

    NSDL National Science Digital Library

    This Theodore Roosevelt National Park site contains park geology information, park maps, photographs, related links, visitor information, and teacher features (resources for teaching geology with National Park examples). The park geology section discusses the Park's geologic history and the region's role in shaping Theodore Roosevelt's conservation efforts while he was President. The section also contains a link to information on the geology of Theodore Roosevelt National Park. The park maps section contains an area map as well as two maps detailing the North and South Units of the Park.

  5. Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps.

    PubMed

    Milonski, Jaroslaw; Zielinska-Blizniewska, Hanna; Majsterek, Ireneusz; Przyby?owska-Sygut, Karolina; Sitarek, Przemyslaw; Korzycka-Zaborowska, Barbara; Olszewski, Jurek

    2015-05-01

    Chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most frequently encountered chronic nasal diseases with a significant impact on patient quality of life. The aim of our study was therefore to investigate the association between the POSTN, IL-4, and IL-13 gene expression and the nasal polyp development. The objective of this study was to determine differential expression of POSTN, IL-4, and IL-13 genes in the mucosa and polyps of 63 patients with CRSwNP and 23 chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) when compared with patients with nasal septum deviation (n=18) who were used as controls. The expression level was investigated using reverse transcription-polymerase chain reaction assays in the polyp tissue and the mucosa of paranasal sinus collected while undergoing functional endoscopic sinus surgery. Expression of the mRNAs of all three genes, IL-4, IL-13, and POSTN, was significantly greater in the paired tissues of CRS patients with NPs or without NPs than in control subjects, with highest levels of POSTN and IL-13 seen in CRSwNP. An increased level of POSTN, IL-4, and IL-13 gene expression may be related to the development of chronic rhinosinusitis with nasal polyps, but polyp formation seemed to be associated especially with POSTN and IL-13 expression. PMID:25674935

  6. National Park Service, Nature & Science: Teacher Resources

    NSDL National Science Digital Library

    The National Park Service has developed this exemplary set of educational resources which draws on their greatest assets, namely national parks from Maine to Utah. The materials are specifically designed for teaching geology, but it's easy to see how these items could be incorporated into general science classes. The main area on their homepage features over a dozen teacher guides and park programs that feature detailed geology lessons that draw on the landscapes of Yosemite National Park and the dynamic volcanoes of Hawaii. On the right side of the page, visitors can scan through the "Highlights" area to learn more about online park images, park maps, and even peruse a calendar of upcoming educator workshops. The site is rounded out by the "Geology Books and Media" area, which features information about technical reports, textbooks, and geology-themed children's books.

  7. Galvez Lot Event Parking Guidelines Effective: December 1, 2012

    E-print Network

    Straight, Aaron

    Galvez Lot Event Parking Guidelines Effective: December 1, 2012 Event parking at the improved Galvez Lot The Galvez Lot (L-96) will remain an "event" parking lot, with a maximum parking capacity to be free of charge. Event sponsors arrange for use of the Galvez Lot through Parking & Transportation

  8. Key to car parking (check signs for latest information)

    E-print Network

    Albrecht, David

    Car Pool parking Area 1 parking Key to car parking (check signs for latest information) H J S N K s To Clayton campus and Dandenong Members No.1 car park, entry from the western side of Smith Street. Ticket Street Dandenong Road Princes Highway (Dandenong Road) MRC Guineas Car Park Sir John Monash Drive Main

  9. Status of biotic inventories in US national parks

    Microsoft Academic Search

    Gary S. Waggoner

    1995-01-01

    It is the policy and obligation of the National Park Service to conduct baseline inventories of natural resources preserved in its 32 million hectare National Park System. We evaluated the status of natural resources information in 252 national parks and monuments: those park units that contain significant natural resources. Results show that few parks contain relatively complete systematic inventories for

  10. Real time car parking system using image processing

    Microsoft Academic Search

    Sayanti Banerjee; Pallavi Choudekar; M. K. Muju

    2011-01-01

    Car parking lots are an important object class in many traffic and civilian applications. With the problems of increasing urban traffic congestion and the ever increasing shortage of space, these car parking lots are needed to be well equipped with automatic parking Information and Guidance systems. Goals of intelligent parking lot management include counting the number of parked cars, and

  11. Parking and Transportation Services 622 W. Fayette St.

    E-print Network

    Weber, David J.

    Parking and Transportation Services 622 W. Fayette St. Baltimore, MD 21201 410 706 6603 / Fax 410 706 4342 www.parking.umaryland.edu ATTENTION ALL PARKERS Parking Rules and Regulations Enforcement In order to use parking resources efficiently, maintain parking courtesy, and ensure a safe environment

  12. Parking Information Reserving a Visitor Spot at the Law School

    E-print Network

    Dasgupta, Dipankar

    Parking Information Reserving a Visitor Spot at the Law School Two visitor parking spots and four Office, you can contact lawadmissions@memphis.edu to arrange for the complimentary parking pass for one of the visitor parking spots. If you are a nonAdmissions visitor and wish to request visitor parking, please

  13. Guest Parking at The UGA Hotel and Conference Center

    E-print Network

    Arnold, Jonathan

    Guest Parking at The UGA Hotel and Conference Center During your visit, parking is available in the University's South Campus Parking Deck, located adjacent to the UGA Hotel. Parking Rates: · Dailyfeesare$4forthefirsthour · $1foreachadditionalhour · Maximumof$10foreach24-hour period parked · Specialratesareineffectfor

  14. Geology Fieldnotes: Death Valley National Park, California/Nevada

    NSDL National Science Digital Library

    This Death Valley National Park site contains park geology information, park maps, photographs, visitor information, and teacher features (resources for teaching geology using National Park examples). The Park Geology section contains an exaggerated cross-section showing the vertical rise within Death Valley. A link is provided to Death Valley's expanded geology page.

  15. Public Parking is available at an hourly rate at the University Square car park.

    E-print Network

    Heiser, Gernot

    Public Parking is available at an hourly rate at the University Square car park. Enter via Bouverie for the Advancement of Artificial Intelligence (AAAI), a Fellow of the American Academy of Arts &Sciences (AAAS

  16. Public Parking is available at an hourly rate at the University Square car park.

    E-print Network

    Heiser, Gernot

    Public Parking is available at an hourly rate at the University Square car park. Enter via Bouverie software systems is often considered an art rather than an engineering task. The practical consequences

  17. Public Parking is available at an hourly rate at the University Square car park.

    E-print Network

    Heiser, Gernot

    Public Parking is available at an hourly rate at the University Square car park. Enter via Bouverie's long been interested in medieval and renaissance art and architecture, and has recently been trying

  18. STANFORD UNIVERSITY PARKING & TRANSPORTATION SERVICES 2013-14 CONTRACTOR PARKING PERMIT SPONSORSHIP/APPLICATION

    E-print Network

    ______________________________________ ___________________________________ _______________ PRIMARY SU PROJECT MANAGER PRINT NAME DATESTANFORD UNIVERSITY PARKING & TRANSPORTATION SERVICES 2013-14 CONTRACTOR PARKING PERMIT SPONSORSHIP department) Sponsoring SU department SU Project Manager Campus phone (required) ( ) I am sponsoring applicant

  19. IL23 Is Increased in Dendritic Cells in Multiple Sclerosis and Down-Regulation of IL23 by Antisense Oligos Increases Dendritic Cell IL10 Production

    Microsoft Academic Search

    Adi Vaknin-Dembinsky; Konstantin Balashov; Howard L. Weiner

    IL-23 is a heterodimeric cytokine comprising a p19 subunit associated with the IL-12\\/23p40 subunit. Like IL-12, IL-23 is expressed predominantly by activated dendritic cells (DCs) and phagocytic cells, and both cytokines induce IFN- secretion by T cells. The induction of experimental autoimmune encephalitis, the animal model of multiple sclerosis (MS), occurs in mice lacking IL-12, but not in mice with

  20. Murine bone marrow-derived mast cells as potent producers of IL-9: costimulatory function of IL-10 and kit ligand in the presence of IL-1.

    PubMed

    Stassen, M; Arnold, M; Hültner, L; Müller, C; Neudörfl, C; Reineke, T; Schmitt, E

    2000-06-01

    Recently, the Th2-type cytokine IL-9 was identified by genetic mapping analyses as a key mediator that determines the susceptibility to asthma. This has been further supported by data from IL-9-transgenic mice in which the overexpression of IL-9 in the lung causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. In an accompanying paper, we demonstrate that murine bone marrow-derived mast cells (BMMC) after stimulation with either ionomycin, a combination of ionomycin and IL-1, or via IgE-Ag complexes and IL-1 are very potent producers of IL-9. Herein we show that a dramatic increase of IL-9 production is observed when BMMC activated with ionomycin/IL-1 or with IgE-Ag complexes/IL-1 are treated with either additional kit ligand (KL) or IL-10. Both KL and IL-10 considerably enhance the production of IL-9 mRNA and protein. We were also able to demonstrate that the production of endogenous IL-10 by activated mast cells acts on the production of IL-9. Half-life measurements of IL-9 mRNA revealed no significant effect by KL, but a 2-fold increase of mRNA stability under the influence of IL-10. Reporter gene assays of transfected BMMC showed an enhanced transcriptional activity of the IL-9 promoter in the presence of either IL-10 or KL compared with cells stimulated only with a combination of IL-1 and ionomycin. The influence of KL and IL-10 might be of physiological importance, because it is known that both cytokines are produced by bronchial epithelial cells. PMID:10820228

  1. USGS Repeat Photography Project: Glacier National Park

    NSDL National Science Digital Library

    This project, conducted by the United States Geological Survey (USGS), documents changes over time in the landscape of Glacier National Park, particularly the retreat of the park's glaciers. The project involves pairing historic photos from the park's archives with recent photos to illustrate how the landscape has changed. Users can view and download the photos in pairs with dates and a caption describing the scene and the changes that have taken place.

  2. Evaluation of Noise Pollution in Urban Parks

    Microsoft Academic Search

    Paulo Henrique Trombetta Zannin; Andressa Maria Coelho Ferreira; Bani Szeremetta

    2006-01-01

    The present study provides an evaluation of noise pollution in six Urban Parks located in the city of Curitiba, Brazil. Equivalent\\u000a noise levels (L\\u000a eq) were measured in 303 points (each point measured during 3 min) spread throughout the Parks. Measured values were confronted\\u000a with local legislation (Law 10625) allowed limits, and the Parks were thus classified as “acoustically polluted

  3. A case study of the implementation of a parking fee at R. A. Apffel Park in Galveston, Texas 

    E-print Network

    Albers, Sheryl Druggan

    1982-01-01

    Park in Galveston, Texas. . (May 1982) Sheryl Druggan Albers B. A. , University of' Kentucky Chairman of Advisory Committeei Dr. Robert B. Ditton In the summer o. 1980 the Galveston park Board o Trustees passed a parking fee policy at a previously... the summer of i980 (May - September) when the Galveston Park Board of Trustees implemented a paid parking policy at a previously free beach park - R. A. Apffel Park. Texas State Senator A. R. Schwartz was opposed to the parking fee at the park. He...

  4. ParkNet: drive-by sensing of road-side parking statistics

    Microsoft Academic Search

    Suhas Mathur; Tong Jin; Nikhil Kasturirangan; Janani Chandrashekharan; Wenzhi Xue; Marco Gruteser; Wade Trappe

    2010-01-01

    Urban street-parking availability statistics are challenging to obtain in real-time but would greatly benefit society by reducing traffic congestion. In this paper we present the design, implementation and evaluation of ParkNet, a mobile system comprising vehicles that collect parking space occupancy information while driving by. Each ParkNet vehicle is equipped with a GPS receiver and a passenger-side-facing ultrasonic range-finder to

  5. IL13, IL4R?, and Stat6 Are Required for the Expulsion of the Gastrointestinal Nematode Parasite Nippostrongylus brasiliensis

    Microsoft Academic Search

    Joseph F Urban Jr.; Nancy Noben-Trauth; Debra D Donaldson; Kathleen B Madden; Suzanne C Morris; Mary Collins; Fred D Finkelman

    1998-01-01

    Although IL-4 induces expulsion of the gastrointestinal nematode parasite, Nippostrongylus brasiliensis, from immunodeficient mice, this parasite is expelled normally by IL-4-deficient mice. This apparent paradox is explained by observations that IL-4 receptor ? chain (IL-4R?)-deficient mice and Stat6-deficient mice fail to expel N. brasiliensis, and a specific antagonist for IL-13, another activator of Stat6 through IL-4R?, prevents worm expulsion. Thus,

  6. 75 FR 20885 - National Park Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ...Proclamation 8498--National Park Week, 2010 Proclamation 8499--National Crime Victims' Rights Week, 2010 Proclamation 8500--National Volunteer Week, 2010 Proclamation 8501--National Day of Service and...

  7. Minsoo Park INFSCI 3923 Independent Study Paper

    E-print Network

    Brusilovsky, Peter

    Minsoo Park INFSCI 3923 Independent Study Paper Cognitive Factors in Adaptive Information Access of information access for many people worldwide in electronic environments. Hypermedia users are freed from

  8. Pupils and Parks: Environmental Education in National Parks of Developing Countries.

    ERIC Educational Resources Information Center

    Jacobson, Susan K.; Padua, Suzana M.

    1992-01-01

    Describes two conservation education programs that target local primary schools and use national parks in Malaysian Borneo (Kinabalu Park) and central Brazil (Morro do Diabo Park). Both were designed using a comprehensive systems evaluation model and both resulted in cognitive and affective gains for students. (LB)

  9. Threats to beach resources and park boundaries caused by shoreline migration in an urban estuarine park

    Microsoft Academic Search

    Karl F. Nordstrom; Nancy L. Jackson; John P. Tiefenbacher

    1990-01-01

    An evaluation of coastal processes, shoreline erosion, and shore management options for Conference House Park, New York, USA, reveals the problems associated with lack of congruence between jurisdictional boundaries and boundaries required for maintenance of beaches and shorefront park land. Rates of shoreline change are high despite low wave energies because bay beaches contain small amounts of sand. The park

  10. Commensal Bacteria and MAMPs Are Necessary for Stress-Induced Increases in IL-1? and IL-18 but Not IL-6, IL-10 or MCP-1

    PubMed Central

    Maslanik, Thomas; Tannura, Kate; Mahaffey, Lucas; Loughridge, Alice Brianne; Benninson, Lida; Ursell, Luke; Greenwood, Benjamin N.; Knight, Rob; Fleshner, Monika

    2012-01-01

    Regular interactions between commensal bacteria and the enteric mucosal immune environment are necessary for normal immunity. Alterations of the commensal bacterial communities or mucosal barrier can disrupt immune function. Chronic stress interferes with bacterial community structure (specifically, ?-diversity) and the integrity of the intestinal barrier. These interferences can contribute to chronic stress-induced increases in systemic IL-6 and TNF-?. Chronic stress, however, produces many physiological changes that could indirectly influence immune activity. In addition to IL-6 and TNF-?, exposure to acute stressors upregulates a plethora of inflammatory proteins, each having unique synthesis and release mechanisms. We therefore tested the hypothesis that acute stress-induced inflammatory protein responses are dependent on the commensal bacteria, and more specifically, lipopolysaccharide (LPS) shed from Gram-negative intestinal commensal bacteria. We present evidence that both reducing commensal bacteria using antibiotics and neutralizing LPS using endotoxin inhibitor (EI) attenuates increases in some (inflammasome dependent, IL-1 and IL-18), but not all (inflammasome independent, IL-6, IL-10, and MCP-1) inflammatory proteins in the blood of male F344 rats exposed to an acute tail shock stressor. Acute stress did not impact ?- or ?- diversity measured using 16S rRNA diversity analyses, but selectively reduced the relative abundance of Prevotella. These findings indicate that commensal bacteria contribute to acute stress-induced inflammatory protein responses, and support the presence of LPS-mediated signaling in stress-evoked cytokine and chemokine production. The selectivity of the commensal bacteria in stress-evoked IL-1? and IL-18 responses may implicate the inflammasome in this response. PMID:23236381

  11. IL-33 Facilitates Oncogene Induced Cholangiocarcinoma in Mice by an IL-6 Sensitive Mechanism

    PubMed Central

    Yamada, Daisaku; Rizvi, Sumera; Razumilava, Nataliya; Bronk, Steven F.; Davila, Jaime I.; Champion, Mia D.; Borad, Mitesh J.; Bezerra, Jorge A.; Chen, Xin; Gores, Gregory J.

    2015-01-01

    Cholangiocarcinoma (CCA) is a lethal hepatobiliary neoplasm originating from the biliary apparatus. In humans, CCA risk factors include hepatobiliary inflammation and fibrosis. The recently identified IL-1 family member, IL-33, has been shown to be a biliary mitogen which also promotes liver inflammation and fibrosis. Our aim was to generate a mouse model of CCA mimicking the human disease. Ectopic oncogene expression in the biliary tract was accomplished by the Sleeping Beauty transposon transfection system with transduction of constitutively active AKT (myr-AKT) and Yes-associated protein (YAP). Intrabiliary instillation of the transposon-transposase complex was coupled with lobar bile duct ligation in CL57BL/6 mice, followed by administration of IL-33 for three consecutive days. Tumors developed in 72% of the male mice receiving both oncogenes plus IL-33 by 10 weeks, but in only 20% of the male mice transduced with the oncogenes alone. Tumors expressed SOX9 and pancytokeratin (PanCK) [features of cholangiocarcinoma] but were negative for HepPar1 [a marker of hepatocellular carcinoma (HCC)]. RNA profiling revealed substantive overlap with human CCA specimens. Not only did IL-33 induce IL-6 expression by human cholangiocytes, but IL-33 likely facilitated tumor development in vivo by an IL-6 sensitive process, as tumor development was significantly attenuated in Il-6 -/- male animals. Furthermore, tumor formation occurred at a similar rate when IL-6 was substituted for IL-33 in this model. In conclusion, the transposase-mediated transduction of constitutively active AKT and YAP in the biliary epithelium coupled with lobar obstruction and IL-33 administration results in the development of CCA with morphological and biochemical features of the human disease. This model highlights the role of inflammatory cytokines in CCA oncogenesis. PMID:25580681

  12. IL-33 attenuates the development of experimental autoimmune uveitis

    PubMed Central

    Barbour, Mark; Allan, Debbie; Xu, Heping; Pei, Cheng; Chen, Mei; Niedbala, Wanda; Fukada, Sandra Y; Besnard, Anne-Galle; Alves-Filho, Jose C; Tong, Xiaoguang; Forrester, John V; Liew, Foo Yew; Jiang, Hui-Rong

    2014-01-01

    Interleukin-33 (IL-33) is associated with several important immune-mediated disorders. However, its role in uveitis, an important eye inflammatory disease, is unknown. Here, we investigated the function of IL-33 in the development of experimental autoimmune uveitis (EAU). IL-33 and IL-33 receptor (ST2) were expressed in murine retinal pigment epithelial (RPE) cells in culture, and IL-33 increased the expression of Il33 and Mcp1 mRNA in RPE cells. In situ, IL-33 was highly expressed in the inner nuclear cells of the retina of naďve mice, and its expression was elevated in EAU mice. ST2-deficient mice developed exacerbated EAU compared with WT mice, and administration of IL-33 to WT mice significantly reduced EAU severity. The attenuated EAU in IL-33-treated mice was accompanied by decreased frequency of IFN-?+ and IL-17+ CD4+ T cells and reduced IFN-? and IL-17 production but with increased frequency of IL-5+ and IL-4+ CD4 T cells and IL-5 production in the draining lymph node and spleen. Macrophages from the IL-33-treated mice show a significantly higher polarization toward an alternatively activated macrophage phenotype. Our results therefore demonstrate that the endogenous IL-33/ST2 pathway plays an important role in EAU, and suggest that IL-33 represents a potential option for treatment of uveitis. PMID:25116404

  13. IL-10 Function, Regulation, and in Bacterial Keratitis

    PubMed Central

    Jiang, Xiaoyu; McClellan, Sharon A.

    2014-01-01

    Abstract The immune system protects the host from pathogenic microbes, but tight regulation of the evoked response is requisite to limit bystander damage. The interleukin (IL)-10 family of cytokines, composed of 9 members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and 3 distantly related members, IL-28A, IL-28B, and IL-29, plays a central role in this regulation. IL-10 family cytokines emerged before the adaptive immune response and elicit diverse host defense mechanisms, especially from epithelial cells during an infection. IL-10 family cytokines are also essential for maintenance and integrity of tissue epithelial layers. These cytokines promote innate immune responses from tissue epithelia that limit the damage caused by both viral and bacterial infections. They also facilitate tissue healing after infection/inflammation. In this regard, IL-10 suppresses pro-inflammatory responses, limiting tissue disruption resulting from an inflammatory response. Thus, a central functional theme of IL-10 family cytokines is their role in tissue protection. This review focuses on IL-10, the founding member of this family of cytokines, and integrates recent data on the function and regulation of IL-10 during bacterial infections. Emphasis is placed on the role of IL-10 in Pseudomonas aeruginosa keratitis and the subsequent infectious/inflammatory processes evoked. PMID:24738920

  14. Three-Dimensional Conformal Radiotherapy in Prostate Cancer Patients: Rise in Interleukin 6 (IL-6) but not IL-2, IL-4, IL-5, Tumor Necrosis Factor-{alpha}, MIP-1-{alpha}, and LIF Levels

    SciTech Connect

    Oliveira Lopes, Carlos [Universidade do Vale do Paraiba, Centro de Oncologia Radioterapica do Vale do Paraiba, Universidade do Vale do Paraiba Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraiba, Sao Jose dos Campos, Sao Paulo (Brazil); Callera, Fernando, E-mail: fcallera@gmail.com [Centro de Hematologia Onco-hematologia e Transplantes de Medula Ossea do Vale do Paraiba, Sao Paulo (Brazil)

    2012-03-15

    Purpose: To investigate the effect of radiotherapy (RT) on serum levels of interleukin-2 (IL-2), IL-4, IL-5, IL-6, tumor necrosis factor alpha (TNF-{alpha}), macrophage inflammatory protein-1-alpha (MIP-1-{alpha}) and leukemia inhibitory factor (LIF) in patients with prostate cancer. Methods and Materials: Forty eight patients with prostate cancer received three-dimensional conformal blocking radiation therapy with a linear accelerator. IL-2, IL-4, IL-5, IL-6, TNF-{alpha}, MIP-1-{alpha}, and LIF levels were measured by the related immunoassay kit 1 day before the beginning of RT and during RT at days 15 and 30. Results: The mean IL-2 values were elevated before and during the RT in contrast with those of IL-4, IL-5, IL-6, TNF-{alpha}, MIP-1-{alpha}, and LIF, which were within the normal range under the same conditions. Regarding markers IL-2, IL-4, IL-5, TNF-{alpha}, MIP-1-{alpha}, and LIF, comparisons among the three groups (before treatment and 15 and 30 days during RT) did not show significant differences. Although values were within the normal range, there was a significant rise in IL-6 levels at day 15 of RT (p = 0.0049) and a decline at day 30 to levels that were similar to those observed before RT. Conclusions: IL-6 appeared to peak after 15 days of RT before returning to pre-RT levels. In contrast, IL-2, IL-4, IL-5, TNF-{alpha}, MIP-1-{alpha}, and LIF levels were not sensitive to irradiation. The increased levels of IL-6 following RT without the concurrent elevation of other cytokines involved in the acute phase reaction did not suggest a classical inflammatory response to radiation exposure. Further studies should be designed to elucidate the role of IL-6 levels in patients with prostate cancer treated with RT.

  15. 36 CFR 7.13 - Yellowstone National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...appropriate snow cover, public safety, avalanche conditions, resource protection, park...appropriate snow cover, public safety, avalanche conditions, resource protection, park...appropriate snow cover, public safety, avalanche conditions, park operations,...

  16. UMore Park Sand and Gravel Resources Project University of Minnesota

    E-print Network

    Netoff, Theoden

    UMore Park Sand and Gravel Resources Project University of Minnesota Public Comment Forum and Open ­ Steven Lott, Co-project manager, UMore Park Sand and Gravel Resources Project 6:40 The UMore Park Sand

  17. 76 FR 77552 - Gettysburg National Military Park Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ...Service [4400-SZM] Gettysburg National Military Park Advisory Commission AGENCY: National...September 6, 2012 of the Gettysburg National Military Park Advisory Commission. DATES: The...Education Center in the Gettysburg National Military Park Museum and Visitor Center,...

  18. 76 FR 70483 - Gettysburg National Military Park Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ...Service [4400-SZM] Gettysburg National Military Park Advisory Commission AGENCY: National...September 6, 2012 of the Gettysburg National Military Park Advisory Commission. DATES: The...Education Center in the Gettysburg National Military Park Museum and Visitor Center,...

  19. 115. Doughton Park Recreation Area. View of roadway alignment around ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    115. Doughton Park Recreation Area. View of roadway alignment around alligator back and parking overlook in foreground. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  20. 36 CFR 7.37 - Jean Lafitte National Historical Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.37 Jean Lafitte National Historical Park. (a...ii) Will not be detrimental to other park wildlife or the reproductive potential of the species to be taken; and (iii)...