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1

International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)  

E-print Network

International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009.P. Barry Department of Mechanical Aerospace and Nuclear Engineering, Rensselaer Polytechnic Institute 110 8

Danon, Yaron

2

International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)  

E-print Network

International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009 and Nuclear Engineering Troy, New York, 12180 D.P. Barry, G. Leinweber, N.J. Drindak (ret.), J.G. Hoole Knolls

Danon, Yaron

3

Sixth American Nuclear Society International Topical Meeting on Nuclear Plant Instrumentation, Control, and Human-Machine Interface Technologies NPIC&HMIT 2009, Knoxville, Tennessee, April 5-9, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL  

E-print Network

effects in a 16 x 16 pin fuel assembly. The results show significant shielding of interrogation neutrons for slower neutrons than fast. Also, secondary fissions in the assembly greatly affect the detector response, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009) FUELASSEMBLY SELF SHIELDING

Danon, Yaron

4

Nebraska's Wetlands By Ted LaGrange,  

E-print Network

Nebraska's Wetlands By Ted LaGrange, Wetland Program Manager, Nebraska Game and Parks Commission Nebraska's wetland resources are as diverse and dynamic as those of any state in the nation. They include. Some wetlands hold water for only a few weeks or less during the spring while others never go

Nebraska-Lincoln, University of

5

5. Wick, O. J. (ed.) Plutonium Handbook: a Guide to the Technology 3357 (American Nuclear Society, LaGrange Park, IL, 1980).  

E-print Network

5. Wick, O. J. (ed.) Plutonium Handbook: a Guide to the Technology 33­57 (American Nuclear Society superconductors. Phys. Rev. Lett. 8, 250­253 (1962). 11. Wolfer, W. G. Radiation effects in plutonium. Los Alamos

Dinsmore, Tony

6

The Lagrange Points  

ERIC Educational Resources Information Center

This paper presents a derivation of all five Lagrange points by methods accessible to sixth-form students, and provides a further opportunity to match Newtonian gravity with centripetal force. The predictive powers of good scientific theories are also discussed with regard to the philosophy of science. Methods for calculating the positions of the

Lovell, M.S.

2007-01-01

7

Ejs Lagrange Top Model  

NSDL National Science Digital Library

The Ejs Lagrange Top model displays the motion of a heavy symmetric top under the effect of gravity. The top has an initial angular speed that provides the precessional, nutational, and rotational speeds. The ratio of Lz to L can be set via slider and the initial angular position and angular speeds can be changed via textboxes. You can modify this simulation if you have Ejs installed by right-clicking within the plot and selecting Open Ejs Model from the pop-up menu item. Ejs Lagrange Top model was created using the Easy Java Simulations (Ejs) modeling tool. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the ejs_ehu_rigid_bodies_Lagrange.jar file will run the program if Java is installed. Ejs is a part of the Open Source Physics Project and is designed to make it easier to access, modify, and generate computer models. Additional Ejs models for rigid body dynamics are available. They can be found by searching ComPADRE for Open Source Physics, OSP, or Ejs.

Aguirregabiria, Juan

2008-08-18

8

Noncommutative Lagrange Mechanics  

NASA Astrophysics Data System (ADS)

It is proposed how to impose a general type of ''noncommutativity'' within classical mechanics from first principles. Formulation is performed in completely alternative way, i.e. without any resort to fuzzy and/or star product philosophy, which are extensively applied within noncommutative quantum theories. Newton-Lagrange noncommutative equations of motion are formulated and their properties are analyzed from the pure geometrical point of view. It is argued that the dynamical quintessence of the system consists in its kinetic energy (Riemannian metric) specifying Riemann-Levi-Civita connection and thus the inertia geodesics of the free motion. Throughout the paper, ''noncommutativity'' is considered as an internal geometric structure of the configuration space, which can not be ''observed'' per se. Manifestation of the noncommutative phenomena is mediated by the interaction of the system with noncommutative background under the consideration. The simplest m! odel of the interaction (minimal coupling) is proposed and it is shown that guiding affine connection is modified by the quadratic analog of the Lorentz electromagnetic force (contortion term).

Kochan, Denis

2008-02-01

9

A Modification of Lagrange Interpolation  

Microsoft Academic Search

A modification of Lagrange interpolation based on the zeros of the Chebyshev polynomial of the second kind is constructed, which interpolates at many ofgiven data. Thus, for this node-system the main result gives an affimative answer to a problem suggested by Bernstein in 1930. Moreover, our modification has a Timan-Gopengauz type approximation rate.

T. Xie; X. Zhou

2001-01-01

10

CRAIG G. FRASER"' LAGRANGE'S ANALYTICAL MATHEMATICS,  

E-print Network

, by researchers throughout Europe. Among this group was Auguste Comte, the founder of positive philosophy, whoCRAIG G. FRASER"' LAGRANGE'S ANALYTICAL MATHEMATICS, ITS CARTESIAN ORIGINS AND RECEPTION IN COMTE M. Le Comte J.-L. Lagrange', in: Oeuvres de Lagrange, Vol. 1 (Paris: Gauthier-Villars, 1867). pp. ix

Fraser, Craig

11

Analysis of Lagrange's original derivation of the Euler-Lagrange Differential Equation  

NASA Astrophysics Data System (ADS)

The Euler-Lagrange differential equation provides the Lagrangian equations of motion, and thus allows the exact trajectory of an object in a potential to be found. We analyze the original derivation of the Euler-Lagrange differential equation via a translation of the third edition of Lagrange's Mecanique Analytique (1811). We compare and contrast this derivation with the derivation commonly done in a junior-level classical mechanics course. Lagrange uses several founding concepts to produce a generalized equation of motion for all dynamics. These concepts are, in the order addressed by Lagrange, the Principle of Virtual Velocities, the Conservation des Forces Vives, and the Principle of Least Action. Lagrange then employs what he calls the Method of Variations to the general equation of motion for dynamics to ultimately resolve something similar to the Euler-Lagrange Differential equation we use today. We also compare modern notation with Lagrange's notation.

Laughlin, Ryan; Close, Hunter

2012-03-01

12

International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)  

E-print Network

operator such as EDF, the time required to compute nuclear reactor core simulations is rather critical. Introduction As operator of nuclear power plants, EDF needs many nuclear reactor core simulationsInternational Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009

Vialle, Stéphane

13

Nuclear Mathematical and Computational Sciences: A Century in Review, A Century Anew Gatlinburg, Tennessee, April 6-11, 2003, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2003)  

E-print Network

OF CHANGING DYNAMICS IN PHYSIOLOGICAL TIME SERIES L. M. Hively and V. A. Protopopescu Oak Ridge National Laboratory P. O. Box 2009, Oak Ridge, TN 37831-8066 hivelylm@ornl.gov; protopopesva@ornl.gov ABSTRACT We on model data and applied to various clinically evaluated physiological data to detect early signs

Hively, Lee M.

14

International Conference on Mathematics and Computational Methods Applied to Nuclear Science & Engineering (M&C 2013) Sun Valley, Idaho, USA, May 5-9, 2013, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2013)  

E-print Network

& Engineering (M&C 2013) Sun Valley, Idaho, USA, May 5-9, 2013, on CD-ROM, American Nuclear Society, La be very close to one and convergence may become prohibitively slow. 1934M&C 2013, Sun Valley, Idaho, May 5

Kelley, C. T. "Tim"

15

International Conference on Mathematics and Computational Methods Applied to Nuclear Science & Engineering (M&C 2013) Sun Valley, Idaho, USA, May 5-9, 2013, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2013)  

E-print Network

& Engineering (M&C 2013) Sun Valley, Idaho, USA, May 5-9, 2013, on CD-ROM, American Nuclear Society, La&C 2013, Sun Valley, Idaho, May 5-9, 2013 #12;Jeffrey Willert We seek the the smallest for which Equation

Kelley, C. T. "Tim"

16

Joint International Topical Meeting on Mathematics & Computation and Supercomputing in Nuclear Applications (M&C + SNA 2007) Monterey, California, April 15-19, 2007, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2007)  

E-print Network

for advanced burner reactors call for liquid sodium coolant passing through subassemblies of hexagonally. There are hundreds of assemblies in the reactor. Most thermal-hydraulics analysis is therefore based on subchannel balances at axial positions along the channel. Subchannel models of a full core will have 107 control

Fischer, Paul F.

17

Advances in Nuclear Fuel Management IV (ANFM 2009) Hilton Head Island, South Carolina, USA, April 12-15, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)  

E-print Network

- France merle@lpsc.in2p3.fr Keywords: Molten Salt Reactor, Thorium fuel cycle, fast neutron spectrum, and the salt composition, in terms of safety coefficients, reprocessing requirements, and breeding capabilities concept that we called the Thorium Molten Salt Reactor (TMSR), which is particularly well suited to fulfil

Paris-Sud XI, Université de

18

International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)  

E-print Network

) OPTIMIZATION OF A NOVEL SOLID-STATE SELF POWERED NEUTRON DETECTOR Justin Dingleya , Yaron Danona , Nicholas Li a novel self-powered solid-state neutron detector. New manufacturing techniques, allowing for micron device, and 48 percent for the hexagonal hole design. Key Words: neutron, detection, optimization, solid-state

Danon, Yaron

19

International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)  

E-print Network

) NEGATIVE FLUX FIXUPS IN DISCONTINOUS FINITE ELEMENT SN TRANSPORT Steven Hamilton and Michele Benzi fixup for the linear discontinuous finite element method (LDFEM) which is similar to the classical fixup to the steady-state one-group discrete ordinates radiation transport equation with isotropic scattering

Benzi, Michele

20

1488 IEEE TRANSACTIONS ON IMAGE PROCESSING, VOL. 10, NO. 10, OCTOBER 2001 Lagrange Wavelets for Signal Processing  

E-print Network

imaging. Halfband Lagrange wavelets, B-spline Lagrange wavelets and Gaussian Lagrange [Lagrange for an accurate wavelet analysis, the interpolating wavelet coefficients can be implemented using a parallel

Wei, Guo-Wei

21

Three-dimensional, Free-Lagrange hydrodynamics  

SciTech Connect

This paper describes the algorithms that make up a 3-D version of the Free-Lagrange Method. The basic method involves the explicit integration of the fluid flow equations over control volumes formed by Voronoi cells. A Voronoi cell is an arbitrary, convex polyhedron that has plane polygon faces. The ''nearest'' neighbors of any given mass point are identified by noting the mass point that lies on the opposite side of a given Voronoi face. The nearest neighbors of a mass point are allowed to change in response to the (Lagrange) motion of the mass points. This implies that the mesh reorganizes itself as the mass points move with the fluid motion.

Trease, H.

1987-01-01

22

An Extension of Lagrange's Identity to Matrices. Classroom Notes  

ERIC Educational Resources Information Center

In this note the well-known Lagrange identity is extended to matrices. The resulting generalized Lagrange identity is used to give characterizations of symmetry, commutativity of projectors and normality.

Trenkler, Gotz

2004-01-01

23

Su un'estensione della teoria di Lagrange per i moti secolari  

E-print Network

La teoria di Lagrange per i moti secolari delle eccentricit\\`a ed inclinazioni delle orbite planetarie si fondava su un'approssimazione, dettata in larga misura dalla complessit\\`a dei calcoli necessari, che consisteva nel considerare solo equazioni lineari. In questa memoria riprendiamo in considerazione i metodi di Lagrange alla luce della teoria della stabilit\\`a esponenziale di Nekhoroshev. Grazie agli algoritmi sviluppati negli ultimi anni e alle tecniche di manipolazione algebrica possiamo tener conto anche dei contributi non lineari alle equazioni. Come applicazione cerchiamo di determinare i tempi di stabilit\\`a per il problema dei tre corpi nel caso del Sole e dei due pianeti maggiori, Giove e Saturno, mostrando che si possono ottenere risultati realistici, ancorch\\'e non ottimali. Lagrange's theory for the secular motion of perihelia and nodes of the planetary orbits was based on consideration of a linear approssimation of the dynamical equations, compatible with the complexity of the calculations. We extend Lagrange's investigations in the light of Nekhoroshev's theory of exponential stability. Using effective algorithms recently developed and computer algebra we investigate the non linear problem. We apply our methods to the problem of three bodies in the Sun-Jupiter-Saturn case, thus showing that realistic results, although not optimal, can be obtained.

Antonio Giorgilli; Ugo Locatelli; Marco Sansottera

2013-03-29

24

Lagrange-mesh calculations and Fourier transform  

SciTech Connect

The Lagrange-mesh method is a very accurate procedure for computing eigenvalues and eigenfunctions of a two-body quantum equation written in the configuration space. Using a Gauss quadrature rule, the method only requires the evaluation of the potential at some mesh points. The eigenfunctions are expanded in terms of regularized Lagrange functions, which vanish at all mesh points except one. Using the peculiarities of the method, it is shown that the Fourier transform of the eigenfunctions, computed in the configuration space, can easily be obtained with good accuracy in the physical domain of the momentum space. Also, observables in this space can easily be computed with good accuracy only using matrix elements and eigenfunctions computed in the configuration space.

Lacroix, Gwendolyn; Semay, Claude [Service de Physique Nucleaire et Subnucleaire, Universite de Mons-UMONS, Academie universitaire Wallonie-Bruxelles, Place du Parc 20, B-7000 Mons (Belgium)

2011-09-15

25

Lagrange's principle in extremum problems with constraints  

NASA Astrophysics Data System (ADS)

In this paper a general result concerning Lagrange's principle for so-called smoothly approximately convex problems is proved which encompasses necessary extremum conditions for mathematical and convex programming, the calculus of variations, Lyapunov problems, and optimal control problems with phase constraints. The problem of local controllability for a dynamical system with phase constraints is also considered. In an appendix, results are presented that relate to the development of a 'Lagrangian approach' to problems where regularity is absent and classical approaches are meaningless. Bibliography: 33 titles.

Avakov, E. R.; Magaril-Il'yaev, G. G.; Tikhomirov, V. M.

2013-06-01

26

Interpretation of Lagrange multipliers in nonlinear pricing problem  

Microsoft Academic Search

The Lagrange multipliers in the pricing problem can be interpreted as a network of directed flows between the buyer types. The multipliers satisfy a conservation law for each node, and the non-uniqueness of the multipliers are connected to the stability of the solution structure. Joseph-Louis Lagrange introduced the multiplier method in calculus of variations in his 1804 book Lecons sur

Kimmo Berg; Harri Ehtamo

2010-01-01

27

CONVERGENCE OF A SUBSTRUCTURING METHOD WITH LAGRANGE MULTIPLIERS \\Lambda  

E-print Network

finite element discretization of an elliptic boundary value problem into Neumann problems with Lagrange multipliers, proposed by Farhat and Roux [10] under the name Finite Element Tearing conjugate gradients. This idea is related to the fictitious domain method where the Lagrange multipliers

Mandel, Jan

28

Lagrange multiplier based transport theory for quantum wires  

NASA Astrophysics Data System (ADS)

We discuss how the Lagrange multiplier method of nonequilibrium steady state statistical mechanics can be applied to describe the electronic transport in a quantum wire. We describe the theoretical scheme using a tight-binding model. The Hamiltonian of the wire is extended via a Lagrange multiplier to "open" the quantum system and to drive current through it. The diagonalization of the extended Hamiltonian yields the transport properties of wire. We show that the Lagrange multiplier method is equivalent to the Landauer approach within the considered model.

Kosov, D. S.

2004-04-01

29

Rayleigh-Lagrange formalism for classical dissipative systems.  

PubMed

It is often believed that the Rayleigh-Lagrange formalism for classical dissipative systems is unable to encompass forces described by nonlinear functions of the velocities. Here we show that this is indeed a misconception. PMID:25679729

Virga, Epifanio G

2015-01-01

30

IL-12/IL-23 Salmonella  

E-print Network

Keywords Immunity IL-12/IL-23 Salmonella Cryptococcus » Prof. Dr. Gottfried Alber Interleukin.; Kastelein, r. a.; alBer, G. Protective immunity to systemic infection with attenuated Salmonella enterica se

Schüler, Axel

31

Structural optimization with constraints from dynamics in Lagrange  

NASA Technical Reports Server (NTRS)

Structural optimization problems are mostly solved under constraints from statics, such as stresses, strains, or displacements under static loads. But in the design process, dynamic quantities like eigenfrequencies or accelerations under dynamic loads become more and more important. Therefore, it is obvious that constraints from dynamics must be considered in structural optimization packages. This paper addresses the dynamics branch in MBB-LAGRANGE. It will concentrate on two topics, namely on the different formulations for eigenfrequency constraints and on frequency response constraints. For the latter the necessity of a system reduction is emphasized. The methods implemented in LAGRANGE are presented and examples are given.

Pfeiffer, F.; Kneppe, G.; Ross, C.

1990-01-01

32

Prospect Park  

NSDL National Science Digital Library

While many readers may be aware that trees grow in Brooklyn, few may be cognizant of the fact that, yes, a forest grows in Brooklyn. This urban forest just happens to be in the boroughâs own lovely Prospect Park, designed by those giants of landscape architects, Frederick Law Olmsted and Calvert Vaux. Often overlooked by some who are primarily concerned with that other large swath of green in the middle of Manhattan, Prospect Park contains a 90-acre meadow, a zoo, a celebrated performing arts festival, and a lake. Visitors to the Prospect Park Alliance website can learn all about these things, and also delve into the parkâs history. Those planning a visit may wish to look at the âGeneral Infoâ and âPlaces To Goâ sections for a selection of brief descriptions and photographs. For those seeking a historical perspective the âHistory & Natureâ area is delightful. Here visitors can learn about the parkâs historical development and creation, and learn more about those individuals responsible for the parkâs design and aesthetic appeal. Finally, visitors should look at the online exhibit âA Glimpse Of Prospect Parkâ for a bit of visual perspective on the parkâs history.

Prospect Park (New York, N.Y.)

33

National Parks  

NSDL National Science Digital Library

This online directory focuses on national parks throughout the country that offer educational opportunities. Where possible, it includes the following information for each: the type of support offered, including educational materials, access to a naturalist or specialists, and classes/workshops; and mailing address and contact information. In addition, a link to the National Park Service's Web site is included.

34

EULER-LAGRANGE CHANGE OF VARIABLES IN CONSERVATION LAWS  

E-print Network

EULER-LAGRANGE CHANGE OF VARIABLES IN CONSERVATION LAWS YUE-JUN PENG Laboratoire de Math@math.univ-bpclermont.fr Abstract : We introduce a new method for studying the Cauchy problem for systems of conservation laws-Infeld equations. An explicit formula of its entropy solution is also provided. Keywords. Conservation laws, change

Boyer, Edmond

35

MULTILEVEL PRECONDITIONERS FOR LAGRANGE MULTIPLIERS IN DOMAIN IMBEDDING \\Lambda  

E-print Network

complement related to Lagrange multipliers is based on a special sparse imple­ mentation of BPX/MDS method. There exist several variants of these methods for such problems. One possibility is to use standard finite element approximation of the problem, and by suitably extending the arising coefficient matrix one gets

36

Weyl-Cartan-Weitzenbck gravity through Lagrange multiplier  

NASA Astrophysics Data System (ADS)

We consider an extension of the Weyl-Cartan-Weitzenbck (WCW) and teleparallel gravity in which the Weitzenbck condition of the exact cancellation of curvature and torsion in a Weyl-Cartan geometry is inserted into the gravitational action via a Lagrange multiplier. In the standard metric formulation of the WCW model, the flatness of the space-time is removed by imposing the Weitzenbck condition in the Weyl-Cartan geometry, where the dynamical variables are the space-time metric, the Weyl vector and the torsion tensor, respectively. However, once the Weitzenbck condition is imposed on the Weyl-Cartan space-time, the metric is not dynamical, and the gravitational dynamics and evolution are completely determined by the torsion tensor. We show how to resolve this difficulty and generalize the WCW model by imposing the Weitzenbck condition on the action of the gravitational field through a Lagrange multiplier. The gravitational field equations are obtained which explicitly depend on the Lagrange multiplier. As a particular model we consider the case of the Riemann-Cartan space-times with zero nonmetricity which mimics the teleparallel theory. The Newtonian limit of the model is investigated and a generalized Poisson equation is obtained, with the weak field gravitational potential explicitly depending on the Lagrange multiplier and on the Weyl vector. The cosmological implications of the theory are also studied, and three classes of exact cosmological models are considered.

Haghani, Zahra; Harko, Tiberiu; Sepangi, Hamid Reza; Shahidi, Shahab

2013-08-01

37

Augmented Lagrange Hopfield network for economic dispatch problems  

NASA Astrophysics Data System (ADS)

This paper proposes augmented Lagrange Hopfield network (ALHN) for solving economic dispatch (ED) problems. The proposed ALHN is a new improvement of continuous Hopfield neural network by using augmented Lagrange function as its energy function. The ALHN is applied for solving different ED problems consisting of classical ED, ED with fuel constraint, ED with piecewise quadratic fuel cost, ED with prohibited operating zones, combined heat and power ED, and ED for hydrothermal systems. The proposed method has been tested on different systems and the obtained results are compared to those from other methods. The result comparison has shown that the proposed ALHN can obtain less total costs and faster computational times than many others. Therefore, ALHN could be a very powerful method for solving the ED problems.

Dieu, Vo Ngoc; Schegner, Peter; Ongsakul, Weerakorn

2012-11-01

38

Accurate solution of the Dirac equation on Lagrange meshes  

NASA Astrophysics Data System (ADS)

The Lagrange-mesh method is an approximate variational method taking the form of equations on a grid because of the use of a Gauss quadrature approximation. With a basis of Lagrange functions involving associated Laguerre polynomials related to the Gauss quadrature, the method is applied to the Dirac equation. The potential may possess a 1/r singularity. For hydrogenic atoms, numerically exact energies and wave functions are obtained with small numbers n +1 of mesh points, where n is the principal quantum number. Numerically exact mean values of powers -2 to 3 of the radial coordinate r can also be obtained with n +2 mesh points. For the Yukawa potential, a 15-digit agreement with benchmark energies of the literature is obtained with 50 or fewer mesh points.

Baye, Daniel; Filippin, Livio; Godefroid, Michel

2014-04-01

39

Accurate solution of the Dirac equation on Lagrange meshes.  

PubMed

The Lagrange-mesh method is an approximate variational method taking the form of equations on a grid because of the use of a Gauss quadrature approximation. With a basis of Lagrange functions involving associated Laguerre polynomials related to the Gauss quadrature, the method is applied to the Dirac equation. The potential may possess a 1/r singularity. For hydrogenic atoms, numerically exact energies and wave functions are obtained with small numbers n+1 of mesh points, where n is the principal quantum number. Numerically exact mean values of powers -2 to 3 of the radial coordinate r can also be obtained with n+2 mesh points. For the Yukawa potential, a 15-digit agreement with benchmark energies of the literature is obtained with 50 or fewer mesh points. PMID:24827362

Baye, Daniel; Filippin, Livio; Godefroid, Michel

2014-04-01

40

The unexplained accuracy of the Lagrange-mesh method.  

PubMed

The Lagrange-mesh method is an approximate variational calculation which resembles a mesh calculation because of the use of a Gauss quadrature. In order to analyze its accuracy, four different Lagrange-mesh calculations based on the zeros of Laguerre polynomials are compared with exact variational calculations based on the corresponding Laguerre basis. The comparison is performed for three solvable radial potentials: the Morse, harmonic-oscillator, and Coulomb potentials. The results show that the accuracies of the energies obtained for different partial waves with the different mesh approximations are very close to the variational accuracy, even in the presence of the centrifugal singularity. The same property holds for the approximate wave functions. This striking accuracy remains unexplained. PMID:11863688

Baye, D; Hesse, M; Vincke, M

2002-02-01

41

The elusive d'Alembert-Lagrange dynamics of nonholonomic systems  

NASA Astrophysics Data System (ADS)

While the d'Alembert-Lagrange principle has been widely used to derive equations of state for dynamical systems under holonomic (geometric) and non-integrable linear-velocity (kinematic) constraints, its application to general kinematic constraints with a general velocity and acceleration-dependence has remained elusive, mainly because there is no clear method, whereby the set of linear conditions that restrict the virtual displacements can be easily extracted from the equations of constraint. We show how this limitation can be resolved by requiring that the states displaced by the variation are compatible with the kinematic constraints. A set of linear auxiliary conditions on the displacements is established and adjoined to the d'Alembert-Lagrange equation via Lagrange's multipliers to yield the equations of state. As a consequence, new transpositional relations satisfied by the velocity and acceleration displacements are also established. The theory is tested for a quadratic velocity constraint and for a nonholonomic penny rolling and turning upright on an inclined plane.

Flannery, M. R.

2011-09-01

42

Park Search  

NSDL National Science Digital Library

Its never too early to begin planning your summer vacation, especially in the depths of winter; those with cabin fever can get a jump on their outdoor recreation plans at this site, provided by L.L. Bean. Users can search this database of over 1,400 state and national parks, forests, and wildlife refuges by state, region, and/or activities in which they are interested (including winter sports for all-season recreators). Search returns include contact information, an overview of the park/ forest and its highlights, photos, and a list of approved or available activities.

43

Park Smart  

NASA Technical Reports Server (NTRS)

The Parking Garage Automation System (PGAS) is based on a technology developed by a NASA-sponsored project called Robot sensorSkin(TM). Merritt Systems, Inc., of Orlando, Florida, teamed up with NASA to improve robots working with critical flight hardware at Kennedy Space Center in Florida. The system, containing smart sensor modules and flexible printed circuit board skin, help robots to steer clear of obstacles using a proximity sensing system. Advancements in the sensor designs are being applied to various commercial applications, including the PGAS. The system includes a smartSensor(TM) network installed around and within public parking garages to autonomously guide motorists to open facilities, and once within, to free parking spaces. The sensors use non-invasive reflective-ultrasonic technology for high accuracy, high reliability, and low maintenance. The system is remotely programmable: it can be tuned to site-specific requirements, has variable range capability, and allows remote configuration, monitoring, and diagnostics. The sensors are immune to interference from metallic construction materials, such as rebar and steel beams. Inside the garage, smart routing signs mounted overhead or on poles in front of each row of parking spots guide the motorist precisely to free spaces.

1999-01-01

44

75 FR 52013 - Notice of Intent to Repatriate Cultural Items: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Cultural Items: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History (Field Museum), Chicago, IL, that...OR, for the Field Museum of Natural History. The items were accessioned into...

2010-08-24

45

78 FR 55219 - Safety Zone; Flying Machine Competition, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...RIN 1625-AA00 Safety Zone; Flying Machine Competition, Chicago, IL AGENCY: Coast...Michigan near Burnham Park during a flying machine competition event in Chicago, IL on September...Delegation No. 0170.1. An annual flying machine competition event has been scheduled...

2013-09-10

46

Theodore Roosevelt National Park  

NSDL National Science Digital Library

This National Park Service website contains information on: the park history; park activities such as hiking and camping; and natural history such as the wildlife, geology and paleontology of the park. The kids' section contains coloring pages, a park trivia quiz, reference sections on the wildlife and natural history of the park, and information on Theodore Roosevelt and his involvement in the Badlands. There are also images of the wildlife and scenery of the park.

47

Stability, Boundedness, and Lagrange Stability of Fractional Differential Equations with Initial Time Difference  

PubMed Central

Differential inequalities, comparison results, and sufficient conditions on initial time difference stability, boundedness, and Lagrange stability for fractional differential systems have been evaluated. PMID:24693255

iek, Muhammed; Yakar, Co?kun; O?ur, Blent

2014-01-01

48

16QAM Blind Equalization via Maximum Entropy Density Approximation Technique and Nonlinear Lagrange Multipliers  

PubMed Central

Recently a new blind equalization method was proposed for the 16QAM constellation input inspired by the maximum entropy density approximation technique with improved equalization performance compared to the maximum entropy approach, Godard's algorithm, and others. In addition, an approximated expression for the minimum mean square error (MSE) was obtained. The idea was to find those Lagrange multipliers that bring the approximated MSE to minimum. Since the derivation of the obtained MSE with respect to the Lagrange multipliers leads to a nonlinear equation for the Lagrange multipliers, the part in the MSE expression that caused the nonlinearity in the equation for the Lagrange multipliers was ignored. Thus, the obtained Lagrange multipliers were not those Lagrange multipliers that bring the approximated MSE to minimum. In this paper, we derive a new set of Lagrange multipliers based on the nonlinear expression for the Lagrange multipliers obtained from minimizing the approximated MSE with respect to the Lagrange multipliers. Simulation results indicate that for the high signal to noise ratio (SNR) case, a faster convergence rate is obtained for a channel causing a high initial intersymbol interference (ISI) while the same equalization performance is obtained for an easy channel (initial ISI low). PMID:24723813

Mauda, R.; Pinchas, M.

2014-01-01

49

Taylor-Lagrange renormalization and gauge theories in four dimensions  

NASA Astrophysics Data System (ADS)

The treatment of gauge theories within the recently proposed Taylor-Lagrange renormalization scheme (TLRS) is examined in detail. The conservation of gauge symmetry is demonstrated directly at the physical dimension D = 4 for specific examples of fermion and boson self energies and vertices of QED and QCD. Comparisons with dimensional regularization and Bogoliubov-Parasiuk-Hepp-Zimmermann (BPHZ) substractions, improved by algebraic regularization based on the quantum action principle, exhibit clearly the important mathematical properties of the TLRS leading to conservation of this fundamental gauge symmetry.

Mutet, B.; Grang, P.; Werner, E.

2012-08-01

50

Lagrange-Dirac systems for charged particles in gauge fields  

E-print Network

In this work, we use the Sternberg phase space (which may be considered as the classical phase space of particles in gauge fields) in order to explore the dynamics of such particles in the context of Lagrange-Dirac systems and their associated Hamilton-Pontryagin variational principles. For this, we develop an analogue of the Pontryagin bundle in the case of the Sternberg phase space. Moreover, we show the link of this new bundle to the so-called magnetized Tulczyjew triple, which is an analogue of the link between the Pontryagin bundle and the usual Tulczyjew triple. Taking advantage of the symplectic nature of the Sternberg space, we induce a Dirac structure on the Sternberg-Pontryagin bundle which leads to the Lagrange-Dirac structure that we are looking for. We also analyze the intrinsic and variational nature of the equations of motion of particles in gauge fields in regards of the defined new geometry. Lastly, we illustrate our theory through the case of a $U(1)$ gauge group, leading to the paradigmatic example of a electricaly charged particle in an electromagnetic field.

Fernando Jimenez

2014-10-13

51

Park It!  

NSDL National Science Digital Library

The difference between an architect and an engineer is sometimes confusing because their roles in building design can be similar. Students experience a bit of both professions by following a set of requirements and meeting given constraints as they create a model parking garage. They experience the engineering design process first-hand as they design, build and test their models. They draw a blueprint for their design, select the construction materials and budget their expenditures. They also test their structures for strength and find their maximum loads.

Integrated Teaching And Learning Program And Laboratory

52

National Environmental Research Parks  

SciTech Connect

The National Environmental Research Parks are outdoor laboratories that provide opportunities for environmental studies on protected lands that act as buffers around Department of Energy (DOE) facilities. The research parks are used to evaluate the environmental consequences of energy use and development as well as the strategies to mitigate these effects. They are also used to demonstrate possible environmental and land-use options. The seven parks are: Fermilab National Environmental Research Park; Hanford National Environmental Research Park; Idaho National Environmental Research Park; Los Alamos National Environmental Research Park; Nevada National Environmental Research Park; Oak Ridge National Environmental Research Park; and Savannah River National Environmental Research Park. This document gives an overview of the events that led to the creation of the research parks. Its main purpose is to summarize key points about each park, including ecological research, geological characteristics, facilities, and available databases.

Not Available

1994-07-01

53

POLICE, PARKING AND TRANSPORTATION Parking Services  

E-print Network

-tax. There will not be an automatic rollover this year): Fill in, print, and sign Faculty/Staff Vehicle Registration form. Send PARKING PERMITS ONLINE button, then select the PURCHASE PERMITS link, sign in and then select the PAY YOUR CITATION ONLINE button or the BUY PARKING PERMITS ONLINE button, then the MANAGE MY PARKING

Mohanty, Saraju P.

54

From reversible computation to quantum computation by Lagrange interpolation  

E-print Network

Classical reversible circuits, acting on $w$~bits, are represented by permutation matrices of size $2^w \\times 2^w$. Those matrices form the group P($2^w$), isomorphic to the symmetric group {\\bf S}$_{2^w}$. The permutation group P($n$), isomorphic to {\\bf S}$_n$, contains cycles with length~$p$, ranging from~1 to $L(n)$, where $L(n)$ is the so-called Landau function. By Lagrange interpolation between the $p$~matrices of the cycle, we step from a finite cyclic group of order~$p$ to a 1-dimensional Lie group, subgroup of the unitary group U($n$). As U($2^w$) is the group of all possible quantum circuits, acting on $w$~qubits, such interpolation is a natural way to step from classical computation to quantum computation.

Alexis De Vos; Stijn De Baerdemacker

2015-02-03

55

Fit of a Distribution Likelihood Function Likelihood Ratio Lagrange Multipliers Hanging Chi-Gram Goodness of Fit  

E-print Network

Fit of a Distribution Likelihood Function Likelihood Ratio Lagrange Multipliers Hanging Chi-Gram Likelihood Ratio Lagrange Multipliers Hanging Chi-Gram Outline Fit of a Distribution Blood Bank Likelihood Function Likelihood Ratio Lagrange Multipliers Hanging Chi-Gram 2 / 14 #12;Fit of a Distribution Likelihood

Watkins, Joseph C.

56

CLAYTONCLAYTON FOREST PARK  

E-print Network

TAYLOR TAYLOR FOREST PARK FOREST PARK EUCLID EUCLID KINGSHIGHWAY KINGSHIGHWAY EUCLID EUCLID FOREST PARK 4480 Clayton [HR] (45) 103 Grassy wedge at the corner of Clayton & Euclid Ave. Shriner's (8), BCL (7 Clayton (27) 105 Northeast corner of Hudlin Park (near corner of Euclid & BJH Plaza) South Bldg.(3

Subramanian, Venkat

57

PARKING PROGRAMS FOR UNIVERSITIES.  

ERIC Educational Resources Information Center

PARKING FACILITIES WERE SURVEYED AT 83 REPRESENTATIVE UNIVERSITIES AND COLLEGES, AND THE METHODS USED IN ADMINISTERING, CONTROLLING AND FINANCING WERE EVALUTED. GENERAL RECOMMENDATIONS WERE MADE CONCERNING (1) THE LOCATION AND DESIGN OF PARKING LOTS AND GARAGES, (2) THE PRACTICE OF CURB PARKING ON CAMPUS, AND (3) THE FINANCING OF PARKING

KINNE, W.S., JR.

58

PARKING AND BACKING BASICS  

E-print Network

the real number is most likely much higher. For fleets, parking lot crashes are one of the most commonly: THURSDAY Parking lot incidents are typically low- speed collisions, but they can still lead to expensive in parking lots. Since many parking lot collisions involve only property damage, many often go unreported, so

Kirschner, Denise

59

Grand Teton National Park  

NSDL National Science Digital Library

This National Park Service website provides a trip planner, information on natural and cultural history, publications, a park fact sheet for students, park maps, student bibliography, and a newspaper for kids. There is information on the geology, rock formations, mountain building, volcanism, and glaciation of the Teton Range. Educational resources for students and teachers consist of links to other National Park Service sites.

60

Interferometric Characterization of the Earth's Atmosphere from Lagrange Point 2  

NASA Technical Reports Server (NTRS)

Part of the NASA plans for future Earth Science missions calls for observations using novel vantage points that can produce science products otherwise unobtainable. Observations of the Earth from the Lagrange-2 point, L-2, (1.5 million km behind the Earth on the Earth-Sun line) affords a unique vantage point for atmospheric science. Spectral observation of the Earth's atmosphere using solar occultation techniques in the near infrared (1 to 4 microns) provides one of the most accurate methods of passively sensing attitude profiles of the major species (CO2, O3, O2, CH4, H2O N2O). While traditional polar orbiting occultation measurements can obtain about 14 measurements per day (2 per orbit), solar occultation observations from the Lagrange-2 point will yield hourly profile measurements at all latitudes. The expected spatial resolution is 2 km in altitude, 0.5 degrees in latitude, and 2 degrees in longitude. The result from 24 hours of observations will be a three-dimensional map of atmospheric composition. To accomplish this task from L-2 requires the development of a large moderate spectral resolution instrument whose entrance aperture is about 10 meters. Use of a standard telescope design with a 10-meter circular mirror or a 10-meter strip mirror would be prohibitively expensive and excessively massive. Instead, we are proposing the development of a 10-meter linear interferometer coupled to a Fourier transform imaging spectrometer. The result will be a highly efficient design with sufficient sensitivity, while having both spatial and spectral resolution to produce the desired results. Preliminary calculations show that seven species (CO2, O3, O2, CH4, H2O N2O) have clearly separated spectral features in the I to 4 microns range with sufficient absorption to produce profile information from near the Earth's surface to the middle stratosphere. For CO2 the estimated sensitivity to change is 0.33% or 1 part in 330. This should be sufficient to detect changes that are significant for the carbon cycle studies. Initial instrument design studies are underway to determine the optimum optical design for the interferometer-spectrometer as well as the necessary highly stable mechanical designs. Separate design studies are being conducted for the spacecraft. shuttle launch facility, low-light solar power design, thermal control, and unique navigation requirements to reach and maintain the tight halo orbit about L-2.

Herman, Jay R.; Komar, George (Technical Monitor)

2001-01-01

61

National Park Service: Tour of Park Geology  

NSDL National Science Digital Library

The tour of Park geologic resources includes pages specific to individual National Parks, Monuments, Recreation Areas, Preserves, Seacoasts, Reserves, and Recreation Areas. These pages are indexed by park name, state, or by one of the following topics: basin and range, caves, Colorado Plateau, fossils, glaciers, hot springs, human use, mountain building, oldest rocks, plate tectonics, river systems, sand dunes, shoreline geology, or volcanoes. Organization of each of the pages typically follows a NPS template with categories for park geology, maps, photographs, geologic research, related links, visitor information, multimedia, and "teacher features" (educational resources and links for teaching geology with National Park examples.) Common subjects that are addressed at various park sites include: minerals, rocks, fossils, cave and karst systems, coastlines, glaciers, volcanoes, faults, landforms, landslides, structures, fluvial systems, sediments, soils, stratigraphic relations, processes that form or act on geologic features and their chemical compositions, and the history of the planet and its life forms.

62

Centrifuge Rotor Models: A Comparison of the Euler-Lagrange and the Bond Graph Modeling Approach  

NASA Technical Reports Server (NTRS)

A viewgraph presentation on centrifuge rotor models with a comparison using Euler-Lagrange and bond graph methods is shown. The topics include: 1) Objectives; 2) MOdeling Approach Comparisons; 3) Model Structures; and 4) Application.

Granda, Jose J.; Ramakrishnan, Jayant; Nguyen, Louis H.

2006-01-01

63

Some generalized Lagrange-based Apostol-Bernoulli, Apostol-Euler and Apostol-Genocchi polynomials  

NASA Astrophysics Data System (ADS)

In this paper, we introduce a general family of Lagrange-based Apostol-type polynomials thereby unifying the Lagrange-based Apostol-Bernoulli and the Lagrange-based Apostol-Genocchi polynomials. We also define Lagrange-based Apostol-Euler polynomials via the generating function. In terms of these generalizations, we find new and useful relations between the unified family and the Apostol-Euler polynomials. We also derive their explicit representations and list some basic properties of each of them. Further relations between the above-mentioned polynomials, including a family of bilinear and bilateral generating functions, are given. Moreover, a generating relation involving the Stirling numbers of the second kind is derived.

Srivastava, H. M.; zarslan, M. A.; Kaano?lu, C.

2013-03-01

64

Acadia National Park: Teachers  

NSDL National Science Digital Library

This National Park Service website contains information on: saving the habitats of peregrine falcons; the water cycle; becoming a junior ranger; and ranger-led school programs, which contain student field activities about the history, biology and geology of the park. Teacher resources include information on a library for educators at the visitor center of the park and teacher guides for preparing to visit the park. The kids' section explains what rangers do, gives tips on leaving no trace in the park, provides a history of Mount Desert Island, and contains an activity to match some park animals to their habitats.

65

Yellowstone Park  

NASA Technical Reports Server (NTRS)

Thirteen years after devastating forest fires burned over 1.6 million acres in Yellowstone National Park, the scars are still evident. In this simulated natural color ASTER image, burned areas appear gray, in contrast to the dark green of unburned forests. The image covers an area of 60 x 63 km. This image was acquired on July 2, 2001 by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet.

ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products.

The broad spectral coverage and high spectral resolution of ASTER will provide scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance.

Dr. Anne Kahle at NASA's Jet Propulsion Laboratory, Pasadena, California, is the U.S. Science team leader; Bjorn Eng of JPL is the project manager. The Terra mission is part of NASA's Earth Science Enterprise, a long- term research effort to understand and protect our home planet. Through the study of Earth, NASA will help to provide sound science to policy and economic decision-makers so as to better life here, while developing the technologies needed to explore the universe and search for life beyond our home planet.

Size: 60 x 63 km (37.2 x 39.1 miles) Location: 44.7 deg. North lat., 110.7 deg. West long. Orientation: North at top Image Data: ASTER bands 1,2, and 3. Original Data Resolution: 15 m Date Acquired: July 2, 2001

2002-01-01

66

Skeletal Pathology in Pan troglodytes schweinfurthii in Kibale National Park, Uganda  

E-print Network

Skeletal Pathology in Pan troglodytes schweinfurthii in Kibale National Park, Uganda Melinda L History, Chicago, IL KEY WORDS skeletal pathology; body size; chimpanzees; poaching; primate health size, morbidity, and mortality are rare for wild chimpanzees. Here, we present skeletal pathology

Pontzer, Herman

67

76 FR 6157 - Meeting of the National Park System Advisory Board  

Federal Register 2010, 2011, 2012, 2013

...Milwaukee, WI. Proposal To Withdraw NHL Designation President (Riverboat), St. Elmo, IL. Proposed Amendments to Existing...Barfoot Park, Cochise County, AZ. Colorado Hanging Lake, Garfield County, CO. Oregon Round Top Butte, Jackson...

2011-02-03

68

Carlsbad Caverns National Park  

NSDL National Science Digital Library

This National Park Service (NPS) website contains details about Carlsbad Caverns National Park in New Mexico. It highlights the natural resources of the park, such as the wilderness, wildlife and caves. The geologic history and formation of caves is covered in detail. There is a teacher's guide with activities, field trip ideas, and factsheets about the park. Topics covered include rocks, erosion, speleothems, mapping caves, fossils, plants and animals, cave bats and fire. Links are provided for more information.

69

Name That Park  

NSDL National Science Digital Library

In this online interactive, learners are introduced to the basic function of Geographic Information System (GIS) maps in relation to national parks. Recognizable park boundaries are presented and learners are given the option to add layers such as lakes, rivers and visitor centers, until the learner is able to identify the park map from a list of choices.

2013-05-15

70

The Paradox of Parks  

Microsoft Academic Search

This article focuses on the Fort Circle Parks of Washington, DC, and also provides examples from other cities to explore the histories, problems, and possibilities of urban parks. As public space, parks are crucial to community and identity. They provide important natural habitats and healthful environments, but they can also become toxic sites. Planners have tried to organize how they

Brett Williams

2006-01-01

71

Parks In Partnership.  

ERIC Educational Resources Information Center

More than 50 National Park Service (NPS) sites interpret Native cultures or early Native contact with Europeans. In about 30 of those, American Indians, Alaska Natives, or Native Hawaiians, in partnership with the NPS, present their own heritage and issues. Describes Native-run aspects of Sitka National Historical Park, Glacier National Park, and

Bowman, Sally-Jo

1998-01-01

72

NATIONAL PARK BOUNDARIES  

EPA Science Inventory

The National Park Service has produced a data base of boundaries for its National Parks. A copy of this data was downloaded from the National Parks Service ftp site by Region 10. These digital boundaries represent the best guess and data that could be collected in a short time....

73

Access into Campus & Parking  

E-print Network

Informational Map May 2012 Livingston Housing Construction Site Road 3 Road Closed SSW Route18 Exit LSC AccessLSC Lot 105 Phase A Access into Campus & Parking Scarlet Lot RAC Livingston Campus Construction into Parking & Day Care From Road 3 Access to Parking Only No Thru Access to Campus Foot path is available

74

How to Park: Teen Drivers  

E-print Network

is important to master because: · Almost 70% of vehicular crashes happen while parking. · 14% of all insurance claims for auto damage involve parking lot collisions. · 80% of bumper scratches occur during parkingHow to Park: The Must- Read Manual for Teen Drivers I 2PARK #12;Welcome to Parking Ed! We know

Das, Suman

75

IL-4 EXACERBATES ANAPHYLAXIS  

Technology Transfer Automated Retrieval System (TEKTRAN)

Studies were established to determine if IL-4, a cytokine critical for inducing allergic responses, contributes to the effector phase of allergy. Pretreatment of mice with IL-4 or the related cytokine, IL-13, rapidly and dramatically increased the severity of anaphylaxis induced by cross-linking Fc...

76

75 FR 45659 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History, Chicago, IL. The human remains and...was made by the Field Museum of Natural History professional staff in consultation...

2010-08-03

77

75 FR 52022 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History, Chicago, IL. The human remains and...remains was made by Field Museum of Natural History professional staff in consultation...

2010-08-24

78

75 FR 438 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History, Chicago, IL. The human remains were...remains was made by Field Museum of Natural History professional staff in consultation...

2010-01-05

79

Capitol Reef National Park  

NSDL National Science Digital Library

This National Park Service (NPS) website provides an in-depth look at Capitol Reef National Park in Utah. Specifically, this covers the geology and natural resources of the park. There is a general overview of the geology of this area including the Waterpocket fold, Colorado Plateau, Cathedral Valley and erosion. There is a description of various rock colors and how they form, as well as a detailed stratigraphic column illustrating the names, thicknesses, and ancient environments of rocks and formations that exist in the park. The Natural Resources section discusses some of the history and archeology of the park, as well as birds, mammals, plants, reptiles and environmental problems.

80

Assessment of Interleukins IL-4, IL-6, IL-8, IL-10 in Acute Urticaria  

PubMed Central

Background Urticaria is a skin disease that affects approximately 5% of the general population and manifests itself, not only as an acute but also as a chronic disease. The etiology of the disease varies as well as its clinical manifestations which extend from the presence of urticarial hives to the potentially mortal angioedema. There is a great interest to the disease not only due to its special clinical manifestation but also due to its pathogenetic mechanism. New data in the medical bibliography support the participation of interleukins (ILs) in the pathophysiology of urticaria. The aim of the study is to contribute in the comprehension of possible participation of certain ILs in the pathogenesis of acute urticaria. Methods Our study concerns four ILs, IL-4, IL-6, IL-8 and IL-10, simultaneously and their quantitative changes during the acute phase of urticaria as well as 2 weeks after drug administration. Moreover, ILs levels of patients were compared with those of matched healthy controls. All measurements have been done by the ELISA method. The statistical analysis was done by SPSS. Results The results present increased levels (in 51 patients vs. 22 matched healthy controls) of all four ILs during the acute phase. Especially for IL-4 this increase was statistically very significant (P < 0.001). Statistically marginally significant decrease was also observed for IL-10 concentrations (P < 0.059), for the two blood samples (acute phase and 2 weeks later). Conclusion It is suggested by the present study that certain ILs might play an important role in the pathogenetic mechanism of urticaria. IL-4 and IL-10 participation seems to be relatively more significant. Possibly, ILs, liberated by mast cells, induce an influx of leukocytes in the dermis, therefore participating in the development of acute urticaria inflammation. PMID:24578755

Papadopoulos, Jordan; Karpouzis, Anthony; Tentes, John; Kouskoukis, Constantin

2014-01-01

81

The National Park Service  

NSDL National Science Digital Library

This is the homepage of the National Park Service. It features links to subpages on special topics such as Parks and Recreation, which inludes links to individual national park pages, and History and Culture, which includes archeological, anthropological, and historical material. The Nature and Science pages feature classroom materials and information on the uses of science in protecting and restoring park ecosystems and research projects which are being conducted in the park system. The Interpretation and Education pages include games, online activities, and material for younger students who are researching park topics, as well as classroom materials for teachers. There are also links to the Park Service online bookshop, news articles, and special features.

82

Theme Park Insider  

NSDL National Science Digital Library

As summer enters full swing, more and more people will travel to America's numerous amusement parks and traveling carnivals. Quite a few of these people would do well to take a look at the Theme Park Insider website for reviews of various parks and the best (and worst) attractions at each particular place of amusement before they venture onto the open road. Edited by Robert Niles, the site contains reviews of new amusement park rides, an "Accident Watch" (which documents the latest accidents at each park), and reviews of theme park hotels as well. The site also has a number of discussion boards for visitors to chime in with their own take on a number of topics, such as which rides have the longest rides and general amusement park lore.

Niles, Robert.

83

Urban Parks: Constraints on Park Visitation  

E-print Network

Research shows that women, older people, members of some ethnic groups, and people with low educational and income levels are less likely than others to participate in leisure activities or visit parks. This publication explores the constraints...

Scott, David

2006-12-19

84

The algebraic index theorem and deformation quantization of Lagrange-Finsler and Einstein spaces  

NASA Astrophysics Data System (ADS)

Various types of Lagrange and Finsler geometries, Einstein gravity, and modifications, can be modelled by nonholonomic distributions on tangent bundles/manifolds when the fundamental geometric objects are adapted to nonlinear connection structures. We can convert such geometries and physical theories into almost Khler/Poisson structures on (co)tangent bundles. This allows us to apply deformation quantization formalism to almost symplectic connections induced by Lagrange-Finsler and/or Einstein fundamental geometric objects. There are constructed respective nonholonomic versions of the trace density maps for the zeroth Hochschild homology of deformation quantization of distinguished algebras (in this work, adapted to nonlinear connection structure). Our main result consists in an algebraic index theorem for Lagrange-Finsler and Einstein spaces. Finally, we show how the Einstein field equations for gravity theories and geometric mechanics models can be imbedded into the formalism of deformation quantization and index theorem.

Vacaru, Sergiu I.

2013-07-01

85

Tennessee State Parks  

NSDL National Science Digital Library

People might know Tennessee for its fabulous Great Smoky Mountains, but have you ever heard of the Cedars of Lebanon or Fall Creek Falls? Oh yes, those two gems are just a small part of the Tennessee State Park system. After looking at some of the beautiful images on the Tennessee State Parks homepage, visitors can explore the Popular Places People Want to Go section to get a taste of the diverse hiking trails, restaurants, camp sites, and other features that are contained throughout the park system. Visitors can also look over over a dozen topical areas, including What to do?, Park Information, and Resource Management. Policy enthusiasts will appreciate the "Estimated Economic Impacts of Tennessee State Parks" report, that is also featured on the homepage, and travelers will love the "Upcoming Events at Tennessee State Parks" area, as it provides a taste of what they might expect on a visit to the Volunteer State.

86

78 FR 21413 - Notice of Intent To Repatriate Cultural Items: The Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Cultural Items: The Field Museum of Natural History, Chicago, IL AGENCY: National Park...SUMMARY: The Field Museum of Natural History, in consultation with the appropriate...request to The Field Museum of Natural History. If no additional claimants come...

2013-04-10

87

Technique to eliminate computational instability in multibody simulations employing the Lagrange multiplier  

NASA Technical Reports Server (NTRS)

A programming technique to eliminate computational instability in multibody simulations that use the Lagrange multiplier is presented. The computational instability occurs when the attached bodies drift apart and violate the constraints. The programming technique uses the constraint equation, instead of integration, to determine the coordinates that are not independent. Although the equations of motion are unchanged, a complete derivation of the incorporation of the Lagrange multiplier into the equation of motion for two bodies is presented. A listing of a digital computer program which uses the programming technique to eliminate computational instability is also presented. The computer program simulates a solid rocket booster and parachute connected by a frictionless swivel.

Watts, G.

1992-01-01

88

Position-dependent mass Lagrangians: non-local transformations, Euler-Lagrange invariance and exact solvability  

E-print Network

A general non-local point transformation for position-dependent mass Lagrangians and their mapping into a "constant unit-mass" Lagrangians in the generalized coordinates is introduced. The conditions on the invariance of the related Euler-Lagrange equations are reported. The harmonic oscillator linearization of the PDM Euler-Lagrange equations is discussed through some illustrative examples including harmonic oscillators, shifted harmonic oscillators, a quadratic nonlinear oscillator, and a Morse-type oscillator. The Mathews-Lakshmanan nonlinear oscillators are reproduced and some "shifted" Mathews-Lakshmanan nonlinear oscillators are reported. The mapping of an isotonic nonlinear oscillator into a PDM deformed isotonic oscillator is also discussed.

Omar Mustafa

2014-11-17

89

Utah Park Brochure  

NSDL National Science Digital Library

You have been asked to create a brochure for one of Utah\\'s many state or national parks to advertise to potential visitors. Overview: After reading Deathwatch, you have now become somewhat of an expert on desert life and survival. Because of your knowledge, you have been asked to create a brochure for one of the state or national parks here in Utah. First, you will select the park or ...

Mrs. Kingsford

2007-01-26

90

Mapping the National Parks  

NSDL National Science Digital Library

This website contains a collection of maps documenting the history, cultural aspects and geological formations of areas that eventually became National Parks. The areas highlighted are Acadia National Park, Yellowstone National Park, the Grand Canyon, and the Great Smoky Mountains. The collection consists of approximately 200 maps dating from the 17th century to the present, reflecting early mapping of these areas. This database is searchable by keyword, geographic location, subject, map creator, or title.

91

Parks, Recreation and Public Health.  

ERIC Educational Resources Information Center

Reviews what current research says about the holistic health benefits of park and recreation services, focusing on: health benefits according to park users; physical activities in parks; stress reduction benefits of park use; social support, self-determination, and stress reduction; observing nature in parks and associated benefits; and the

Ho, Ching-Hua; Payne, Laura; Orsega-Smith, Elizabeth; Godbey, Geoffrey

2003-01-01

92

ARTS & SCIENCES Paradise Park  

E-print Network

COLLEGE OF ARTS & SCIENCES Paradise Park Moderation in Belief The Attraction of Sedimentary Rocks SCIENCES Gauging Protein Activity in Cancer Treatment ... The Attraction of Sedimentary Rocks ... Davis

Napier, Terrence

93

Petrified Forest National Park  

NSDL National Science Digital Library

This National Park Service website offers reference sections on: park wildlife such as reptiles, pronghorns, and the Gunnison prairie dog; the archaeology of park petroglyphs, including some that may be solar calendars; the geology and main features of the Painted Desert; paleontology, which describes dinosaurs of the area; and petrified wood, which explains the petrification process and how the different colors of petrified wood are produced. There are also tips for avoiding diseases such as hantavirus, the plague, and rabies while in the park.

94

Acadia National Park Panorama  

USGS Multimedia Gallery

A panorama of Acadia National Park with Dorr and Cadillac Mountains on the right side, taken from Cadillac Mountain Road. At 1,528 feet in elevation, Cadillac Mountain is the highest point in Acadia National Park, and is composed of a unique granite, the Cadillac Mountain granite unit....

95

Mammoth Cave National Park  

NSDL National Science Digital Library

The homepage of Mammoth Cave National Park provides visitors with information on tour schedules, surface activities, lodging and camping, and tips on touring caves. Teachers can access an extensive selection of curricular materials, fact sheets and activities for kids, a glossary, and links to other educational programs and sites. Other materials include maps and publications, an image gallery, and links to the park's newsletter.

96

Active England `Park Life'  

E-print Network

Active England `Park Life' ­ Greenwood Community Forest Liz O'Brien and Jake Morris Social Life: Design and implementation 6 3. Results: on site surveying and project monitoring 9 3 funded project, `Park Life', within Greenwood Community Forest (hereafter `Greenwood'), and the results

97

Amusement Park Physics  

NSDL National Science Digital Library

Students will research various types of amusement park rides and use their findings to design a feasible ride of their own. They will summarize their findings and present their ride design to the class. Each student will then write a persuasive letter to a local amusement park describing the reasons their ride design is the best.

Janet Fox

2012-06-25

98

Splendor In The Parks.  

ERIC Educational Resources Information Center

Civilization is more and more intruding on the esthetic and recreational resources of the National Park System. Increased attention must be paid to controlling noise, pollution, and even the effects of urban lighting which detract from the enjoyment of the parks. (RE)

Smith, Anthony Wayne

1979-01-01

99

THE SCHOOL PARK.  

ERIC Educational Resources Information Center

TO ASSIST IN DESEGREGATION, VARIOUS MODELS FOR THE SCHOOL PARK ARE PROPOSED--(1) ASSEMBLING ALL STUDENTS AND SCHOOLS OF A SMALL OR MEDIUM-SIZED COMMUNITY ON A SINGLE CAMPUS, (2) SERVING ONE SECTION OF A LARGE CITY, (3) CENTERING ALL SCHOOL FACILITIES FOR A SINGLE LEVEL OF EDUCATION ON A SINGLE SITE, AND (4) ESTABLISHING RINGS OF SCHOOL PARKS ABOUT

FISCHER, JOHN H.

100

Thermodynamics of third order phase transition: A solution to the Euler-Lagrange equations  

Microsoft Academic Search

The thermodynamics expected of systems undergoing third order phase transition has been investigated by identifying the orders through the analytic continuation of the functional of the free energy, using Ehrenfest thermodynamic theory. We developed the Euler-Lagrange equations for the order parameter and the vector potential and solved them for the first time using well-known mathematical formulations.

E. C. Ekuma; G. C. Asomba; C. M. I. Okoye

2010-01-01

101

Thermodynamics of third order phase transition: A solution to the EulerLagrange equations  

Microsoft Academic Search

The thermodynamics expected of systems undergoing third order phase transition has been investigated by identifying the orders through the analytic continuation of the functional of the free energy, using Ehrenfest thermodynamic theory. We developed the EulerLagrange equations for the order parameter and the vector potential and solved them for the first time using well-known mathematical formulations.

E. C. Ekuma; G. C. Asomba; C. M. I. Okoye

2010-01-01

102

1. Mill village dwelling at 817 Forest St. in LaGrange. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Mill village dwelling at 817 Forest St. in LaGrange. Note the hipped roof and wrap-around porch with heavy cornice and Doric columns. The quality of decorative detail here suggests that this house would have been for a mill manager. - 817 Forest Street (House), 817 Forest Street, La Grange, Troup County, GA

103

Fractional variational integrators for fractional Euler-Lagrange equations with holonomic constraints  

NASA Astrophysics Data System (ADS)

In this paper, the fractional variational integrators developed by Wang and Xiao (2012) [28] are extended to the fractional Euler-Lagrange (E-L) equations with holonomic constraints. The corresponding fractional discrete E-L equations are derived, and their local convergence is discussed. Some fractional variational integrators are presented. The suggested methods are shown to be efficient by some numerical examples.

Wang, Dongling; Xiao, Aiguo

2013-04-01

104

Field theory and weak Euler-Lagrange equation for classical particle-field systems  

NASA Astrophysics Data System (ADS)

It is commonly believed as a fundamental principle that energy-momentum conservation of a physical system is the result of space-time symmetry. However, for classical particle-field systems, e.g., charged particles interacting through self-consistent electromagnetic or electrostatic fields, such a connection has only been cautiously suggested. It has not been formally established. The difficulty is due to the fact that the dynamics of particles and the electromagnetic fields reside on different manifolds. We show how to overcome this difficulty and establish the connection by generalizing the Euler-Lagrange equation, the central component of a field theory, to a so-called weak form. The weak Euler-Lagrange equation induces a new type of flux, called the weak Euler-Lagrange current, which enters conservation laws. Using field theory together with the weak Euler-Lagrange equation developed here, energy-momentum conservation laws that are difficult to find otherwise can be systematically derived from the underlying space-time symmetry.

Qin, Hong; Burby, Joshua W.; Davidson, Ronald C.

2014-10-01

105

Oscillatory nonlinear electron flow in a Pierce diode using Lagrange transform  

NASA Astrophysics Data System (ADS)

An electron beam is considered flowing in a one-dimensional electrostatic planar diode with both electrodes grounded. Two integral equations for the electric field, characterizing the Pierce (1944) diode in the cold fluid regime are obtained by using Lagrange transform. These equations agree exactly with those obtained by Godfrey (1987).

El-Labany, S. K.; Rowlands, G.

1989-11-01

106

Field theory and weak Euler-Lagrange equation for classical particle-field systems.  

PubMed

It is commonly believed as a fundamental principle that energy-momentum conservation of a physical system is the result of space-time symmetry. However, for classical particle-field systems, e.g., charged particles interacting through self-consistent electromagnetic or electrostatic fields, such a connection has only been cautiously suggested. It has not been formally established. The difficulty is due to the fact that the dynamics of particles and the electromagnetic fields reside on different manifolds. We show how to overcome this difficulty and establish the connection by generalizing the Euler-Lagrange equation, the central component of a field theory, to a so-called weak form. The weak Euler-Lagrange equation induces a new type of flux, called the weak Euler-Lagrange current, which enters conservation laws. Using field theory together with the weak Euler-Lagrange equation developed here, energy-momentum conservation laws that are difficult to find otherwise can be systematically derived from the underlying space-time symmetry. PMID:25375609

Qin, Hong; Burby, Joshua W; Davidson, Ronald C

2014-10-01

107

VISITOR PARKING MAP Visitor Pay Parking  

E-print Network

SOUTHCOLUMBIASTREET 134 1/2 FRANKLIN STREET BUILDING HILL COMMERCIAL BUILDING PORTHOLE EAST FRANKLIN STREET CHAPEL COMMUNITY SERVIC E BRANSO N STREET BUSINESS SCHOOL PARKING DECK KENAN CENTER KENAN- FLAGLER SCHOOL RESEARCH BLDG. UNIVERSITY DR. BAITY LABS PITTSBORO STREET VANCE STREET M cG AVR AN -G R EEN BER G RO SENAU

North Carolina at Chapel Hill, University of

108

Design a Park  

NSDL National Science Digital Library

In this activity, learners are invited to imagine the park of their dreams! In small groups, learners place moveable pieces on a grid, iterating on their plan together to create a plan for a community park. A variety of park features are offered as choices to include on the map, including a playground, skate park, water features, picnic areas, trails, and more. Like real-world projects, the plan is limited by the realities of space and funds. For younger learners, groups are limited to choosing less than 10 features. Learners ages 9 and up are limited not by the number of features, but by their cost in terms of points: They are challenged to keep track of the points on the park features cards and use less than 250 total points. Some park features, including a natural wetland and ice cream shop, promise to provide revenue back to the community and are worth points. Others, like a skate park or swimming pool, "cost" points. This activity is part of a curriculum designed to engage learners in hands-on engineering challenges.

2014-07-11

109

76 FR 28067 - Notice of Intent To Repatriate Cultural Items: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Cultural Items: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History (Field Museum), Chicago, IL, that...the items to the Field Museum of Natural History. The items were accessioned into...

2011-05-13

110

76 FR 28067 - Notice of Intent To Repatriate Cultural Items: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Cultural Items: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History (Field Museum), Chicago, IL, that...In 1999, the Field Museum of Natural History acquired the cultural items as a...

2011-05-13

111

Project: BEVATRON Parking Bldg. #: 51  

E-print Network

Project: BEVATRON Parking Bldg. #: 51 Parking Impacts: + 202 spaces Date: 8/2013 Project: Seismic Phase II Bldg. #: 74 Parking Impact: - 5 spaces Dates: 10/2009 ­ 12/2012 TRAFFICSAFETYIMPACTS DUE TO CONSTRUCTION AS OF 1/22/2013 Current/Approved Projects Project: SERC Bldg. #: TBD Parking Impact: - 64 spaces

Eisen, Michael

112

Interleukin-1 (IL-1) Pathway  

NSDL National Science Digital Library

The interleukin-1 (IL-1) family of cytokines comprises 11 proteins (IL-1F1 to IL-1F11) encoded by 11 distinct genes in humans and mice. IL-1–type cytokines are major mediators of innate immune reactions, and blockade of the founding members IL-1α or IL-1β by the interleukin-1 receptor antagonist (IL-1RA) has demonstrated a central role of IL-1 in a number of human autoinflammatory diseases. IL-1α or IL-1β rapidly increase messenger RNA expression of hundreds of genes in multiple different cell types. The potent proinflammatory activities of IL-1α and IL-1β are restricted at three major levels: (i) synthesis and release, (ii) membrane receptors, and (iii) intracellular signal transduction. This pathway summarizes extracellular and intracellular signaling of IL-1α or IL-1β, including positive- and negative-feedback mechanisms that amplify or terminate the IL-1 response. In response to ligand binding of the receptor, a complex sequence of combinatorial phosphorylation and ubiquitination events results in activation of nuclear factor κB signaling and the JNK and p38 mitogen-activated protein kinase pathways, which, cooperatively, induce the expression of canonical IL-1 target genes (such as IL-6, IL-8, MCP-1, COX-2, IκBα, IL-1α, IL-1β, MKP-1) by transcriptional and posttranscriptional mechanisms. Of note, most intracellular components that participate in the cellular response to IL-1 also mediate responses to other cytokines (IL-18 and IL-33), Toll-like-receptors (TLRs), and many forms of cytotoxic stresses.

Axel Weber (Germany;Justus-Liebig-University Giessen REV); Peter Wasiliew (Germany;Justus-Liebig-University Giessen REV); Michael Kracht (Germany;Justus-Liebig-University Giessen REV)

2010-01-19

113

Modified Lagrange invariants and their role in determining transverse and axial imaging resolutions of self-interference incoherent holographic systems.  

PubMed

The Lagrange invariant is a well-known law for optical imaging systems formulated in the frame of ray optics. In this study, we reformulate this law in terms of wave optics and relate it to the resolution limits of various imaging systems. Furthermore, this modified Lagrange invariant is generalized for imaging along the z axis, resulting with the axial Lagrange invariant which can be used to analyze the axial resolution of various imaging systems. To demonstrate the effectiveness of the theory, analysis of the lateral and the axial imaging resolutions is provided for Fresnel incoherent correlation holography (FINCH) systems. PMID:25402144

Rosen, Joseph; Kelner, Roy

2014-11-17

114

IL28, IL29 and their class II cytokine receptor IL28R  

Microsoft Academic Search

Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by

Paul Sheppard; Wayne Kindsvogel; Wenfeng Xu; Katherine Henderson; Stacy Schlutsmeyer; Theodore E. Whitmore; Rolf Kuestner; Ursula Garrigues; Carl Birks; Jenny Roraback; Craig Ostrander; Dennis Dong; Jinu Shin; Scott Presnell; Brian Fox; Betty Haldeman; Emily Cooper; David Taft; Teresa Gilbert; Francis J. Grant; Monica Tackett; William Krivan; Gary McKnight; Chris Clegg; Don Foster; Kevin M. Klucher

2002-01-01

115

The Swallow Park Sundials  

NASA Astrophysics Data System (ADS)

The Hermanus Astronomy Centre recently erected a pair of back-to-back sundials in Swallow Park in the centre of Hermanus as part of the upgrading of this historical public park by the Ward committee. Since these two are intended to be the first of many different design sundials to be erected in Hermanus by the HAC, the designs were purposefully chosen to be "unusual" to illustrate the point that even unfamiliar designs and orientations give the same end result....

De Villiers, P.

2014-02-01

116

The National Park Service: Park Geology  

NSDL National Science Digital Library

A National Park Service (NPS) site primarily composed of three main sections corresponding to the following program areas within the Geologic Resources Division (GRD): Disturbed Lands Restoration and Abandoned Mineral Lands (AML), Mineral Management Programs, and Geology and Soils Programs. Of these, the first two consist principally of textual resources pertaining to Park System procedures, policies, and regulations - as well as reports on example restoration projects with a focus on stream corridor restoration, bioengineering, riparian management, and revegetation. Perhaps of most interest to educators will be the third main program area, the Geology and Soils Programs section. Here are included textual resources pertaining to NPS-GRD programs on cave and karst formations, coastal and shoreline geology, paleontology, soils (e.g., soil biology and soil surveying), geological indicators (geoindicators), and stratigraphy. Lastly, a searchable photographic collection and geologic glossary are available.

117

Free-Lagrange simulations of the expansion and jetting collapse of air bubbles in water  

Microsoft Academic Search

A free-Lagrange numerical method is implemented to simulate the axisymmetric jetting collapse of air bubbles in water. This is performed for both lithotripter shock-induced collapses of initially stable bubbles, and for free-running cases where the bubble initially contains an overpressure. The code is validated using two test problems (shock-induced bubble collapse using a step shock, and shock10 MPa tensile waves,

C. K. Turangan; A. R. Jamaluddin; G. J. Ball; T. G. Leighton

2008-01-01

118

Lagrange-Function Approach to Real-Space Order-N Electronic-Structure Calculations  

SciTech Connect

The Lagrange functions are a family of analytical, complete, and orthonormal basis sets that are suitable for efficient, accurate, real-space, order-N electronic-structure calculations. Convergence is controlled by a single monotonic parameter, the dimension of the basis set, and computational complexity is lower than that of conventional approaches. In this paper we review their construction and applications in linearscaling electronic-structure calculations.

Varga, Kalman [ORNL; Pantelides, Sokrates T [ORNL

2006-01-01

119

STABILITY OF LAGRANGE ELEMENTS FOR THE MIXED DOUGLAS N. ARNOLD AND MARIE E. ROGNES  

E-print Network

STABILITY OF LAGRANGE ELEMENTS FOR THE MIXED LAPLACIAN DOUGLAS N. ARNOLD AND MARIE E. ROGNES Computing at Simula Research Laboratory. 1 arXiv:0907.3438v1[math.NA]20Jul2009 #12;2 DOUGLAS N. ARNOLD AND MARIE E. ROGNES Here, · div and · 0 denote the norms on H(div, ) and L2 (), · , · is the L2 () inner

Arnold, Douglas N.

120

Leader-Follower output reference state feedback synchronization control of Euler-Lagrange systems  

Microsoft Academic Search

A coordinated synchronization control scheme to synchronize two or more Euler-Lagrange systems in a leader- follower configuration is presented where the only information requirements of the leader are that of position and orientation only, i.e. the mathematical model with its parameters and the velocity and acceleration of the leader are considered unknown and unmeasured. An model-based nonlinear observer is designed

Erik Kyrkjeb; Kristin Y. Pettersenb

121

Tour of Park Geology: Oldest Rocks  

NSDL National Science Digital Library

This park geology site provides links to tours of individual National Parks, Monuments, and Recreation Areas with the oldest known rocks. The parks are divided at this site into East and West. Where appropriate, for each park, links are provided to park geology, maps, photographs, geologic research, visitor information, multimedia resources, and teacher features (resources for teaching geology using National Park examples). Parks listed include: Voyaguers National Park, Keweenaw National Historic Park, Lake Meade National Recreation Area, and many more.

122

A novel class of anti-IL-12p40 antibodies: potent neutralization via inhibition of IL-12-IL-12R?2 and IL-23-IL-23R.  

PubMed

While current therapeutic antibodies bind to IL-12 and IL-23 and inhibit their binding to IL-12R?1, we describe a novel antibody, termed 6F6, that binds to IL-12 and IL-23 and inhibits the interaction of IL-12 and IL-23 with their cognate signalling receptors IL-12R?2 and IL23R. This antibody does not affect the natural inhibition of the IL-12/23 pathway by the antagonists monomeric IL-12p40 and IL-12p80, which suggests that a dual antagonist system is possible. We have mapped the epitope of 6F6 to domain 3 of the p40 chain common to IL-12 and IL-23 and demonstrate that an antibody bound to this epitope is sufficient to inhibit engagement of the signalling receptors. Antibodies with this unique mechanism of inhibition are potent inhibitors of IL-12 induced IFN-? production and IL-23 induced IL-17 production in vitro, and in an in vivo model of psoriasis, treatment with a humanized variant of this antibody, h6F6, reduced the inflammatory response, resulting in decreased epidermal hyperplasia. We believe that this new class of IL-12/23 neutralising antibodies has the potential to provide improved potency and efficacy as anti-inflammatory agents, particularly in diseases characterized by an overproduction of IL-12. PMID:20724822

Clarke, Adam W; Poulton, Lynn; Wai, Hoi Yi; Walker, Stuart A; Victor, Shanti David; Domagala, Teresa; Mraovic, Dragana; Butt, Danyal; Shewmaker, Nina; Jennings, Philip; Doyle, Anthony G

2010-01-01

123

FACING NORTHWEST TOWARD NORTHERN END OF PARK Candler Park ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FACING NORTHWEST TOWARD NORTHERN END OF PARK - Candler Park Historic District, Roughly bounded by Moreland, Dekalb, McLendon & Harold Avenues, Matthews Street & Clifton Terrace, Atlanta, Fulton County, GA

124

FACING NORTHEAST OF NORTHERN BOUNDARY OF PARK Candler Park ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FACING NORTHEAST OF NORTHERN BOUNDARY OF PARK - Candler Park Historic District, Roughly bounded by Moreland, Dekalb, McLendon & Harold Avenues, Matthews Street & Clifton Terrace, Atlanta, Fulton County, GA

125

NASA Research Park  

NSDL National Science Digital Library

A massive addition to the NASA Ames Research Park is detailed on this site. Although the project is not scheduled to be completed until 2015, it has been in the planning stages for several years and 2003 marks the beginning of Phase 1. The 98-page NASA Ames Development Plan is available for public viewing online. The new facilities will be designed to accommodate research in "information technology, nanotechnology, biotechnology, and astrobiology." Several other news articles and formal documents about the project can be downloaded as well. The design, construction, and staffing of the new research park will reportedly generate 7,000 high-tech jobs.

2000-01-01

126

Glacier (?) National Park  

NSDL National Science Digital Library

This activity engages learners in examining data pertaining to the disappearing glaciers in Glacier National Park. After calculating percentage change of the number of glaciers from 1850 (150) to 1968 (50) and 2009 (26), students move on to the main glacier-monitoring content of the module--area vs. time data for the Grinnell Glacier, one of 26 glaciers that remain in the park. Using a second-order polynomial (quadratic function) fitted to the data, they extrapolate to estimate when there will be no Grinnell Glacier remaining (illustrating the relevance of the question mark in the title of the module).

Mcllrath, University O.; Curriculum/serc, Spreadsheets A.

127

UVA Parking and Transportation Student Parking Application Form  

E-print Network

UVA Parking and Transportation Student Parking Application Form Please Print Clearly: Primary. UVA Parking and Transportation, P.O. Box 400000, Charlottesville, Va. 22904 Attn: Permit Operations Initial: Complete Dorm Address: Complete Home Address: Phone Number: UVA Email Address (Computing ID

Acton, Scott

128

HE -Mof tt Employee Parking WB -Mof tt Employee Parking  

E-print Network

Only E Eye Patients Parking Only Mof tt Patients Parking Only Hope Lodge Parking Only Mof tt Valet Athletics Center ATH Recreation Center REC Sun Dome SUN SE Chiller Plant SEC Library LIB David C. Anchin BEH Faculty Of ce Building FAO C.W. Bill Young Hall CWY Baptist Student Center BPT Catholic Center CTH

Meyers, Steven D.

129

Helping You Buy ILS  

ERIC Educational Resources Information Center

This article is the fourth in a series of articles published annually by "Computers in Libraries" surveying integrated library systems and services (ILSs). The purpose of the annual survey is to enable comparison of the ILSs that are available. ILS vendors are in constant pursuit of an ever-changing, consistently vague definition of what the

Cibbarelli, Pamela R.

2010-01-01

130

Parking Structures and the Space Race.  

ERIC Educational Resources Information Center

Presents some solutions to overcrowded parking on college campuses. Tips on selecting sites for parking garages, making parking decks blend with adjacent communities, and turning parking garages into multi use facilities are addressed. (GR)

Milshtein, Amy

2000-01-01

131

MIDDLE PARK Conservation Action Plan  

E-print Network

MIDDLE PARK Conservation Action Plan 2011 Update Plant Species of Focus: Kremmling milkvetch Conservation Initiative Workshop dates: June 26, 2008 and July 6, 2010 Report date: August 25, 2011 Middle Park................................................................................................................... 6 A. Conservation Targets

132

Lake Manyara Park / Ngorongoro Highlands  

E-print Network

Park (B,L,D) Baobab trees, look for herds of elephants, more than 260 bird species Day 5: Lake ManyaraTanzania. Kikoti Safari Camp (Tarangire National Park)­Thisprivatecampissurroundedbya landscapeofancientboulders,baobab

Shapiro, Benjamin

133

SouthCampus Clinic Parking  

E-print Network

) 6. Roswell Park Cancer Institute 5. Buffalo General 4. Parker Lot 3. Main Circle 2. Goodyear 1. Main. Virginia St. Allen St. NFTA Metro Station at Allen Roswell Park Cancer Institute Buffalo General Hospital

Oh, Kwang W.

134

Carbon Park Environmental Impact Assessment  

E-print Network

of offsetting the University's carbon footprint, promoting biodiversity and establishing easily maintained Carbon Park Environmental Impact Assessment A B.E.S.T. Project By, Adam Bond 2011 #12; Bishop's University Carbon Park

135

The Spatial Logic of Parks  

Microsoft Academic Search

Urban parks are usually studied as discrete, green public open spaces. Less studied is how parks are geographically distributed from a spatial logic point of view, i.e. how they ought to be geographically distributed across the urban landscape. This paper evaluates the degree to which normative principles about park distribution are in evidence from the standpoint of three spatial goals:

Emily Talen

2010-01-01

136

Parking systems analysis: an overview  

Microsoft Academic Search

The availability and quality of parking plays an important role in shaping the overall service provided by the highway system. The usefulness of the automobile can be impaired if the driver is unable to find convenient and reasonably priced parking in the vicinity of his final destination. Further, the design of the parking system can significantly influence the quality of

Raymond H. Ellis; John C. Bennett; Paul R. Rassam

1974-01-01

137

Parking for Fans with Disabilities  

E-print Network

Parking for Fans with Disabilities UVA D3 Lot at Massie and Arlington Welcome to the dedicated parking area for fans with disabilities at Massie and Arlington, also known as the UVA D3 lot! This FREE parking area is provided for fans attending UVA football games. It is adjacent to UVA's Law School and J

Acton, Scott

138

Geology Fieldnotes: Catoctin Mountain Park, Maryland  

NSDL National Science Digital Library

This site contains Catoctin Mountain Park information, a park map, and visitor information. A general cultural history of the park is given, from the first human inhabitants to its development into a park. Also mentioned are recreational attractions and Cunningham Falls State Park, located next to Catoctin. This park lies in the Appalachian Mountain chain.

139

Amusement Park Physics  

NSDL National Science Digital Library

The Amusement Park Physics Website helps the user to learn more about how physics laws affect the designs of roller coasters, bumper car collisions, carousels, free fall rides, and pendulum rides. A highlight of the site is the opportunity to design a roller coaster and experiment with bumper car collisions.

Annenberg/CPB

2007-12-12

140

Toilet Theme Park  

E-print Network

of the world's first toilet culture park centered around a toilet-shaped building that was once the home of Sim Jae-duck, founder of the World Toilet Association, a group dedicated to bringing hygienic bathrooms to all world citizens. Famously born in his poor...

Hacker, Randi

2013-02-27

141

PARKING AND TRAFFIC REGULATIONS  

E-print Network

UNIVERSITY POLICE #12;1 THE PARKING AND TRAFFIC REGULATIONS FOR THE UNIVERSITY OF NEW ORLEANS ARE IN EFFECT regulations which are in effect 24 hours a day/seven days a week. Pedestrians have the right of way; all will reduce the number of crimes on campus. Motor vehicle accidents must be reported to University Police

Li, X. Rong

142

Summer 2013 Pingree Park  

E-print Network

Summer 2013 Pingree Park NR 220-Natural Resource Ecology & Measurements REGISTRATION PROCEDURES 1. Registration will occur through RamWeb. Registration for summer courses begins March 26. (Make sure you choose the Summer Session as RamWeb may default to Fall semeseter.) 2. Registration priority is as follows: Fish

143

The Clover Park Story  

ERIC Educational Resources Information Center

Describes an aviation trades training program offered by the Clover Park schools in Washington which exposes students to all facets of the aviation industry from record keeping to air traffic control in addition to the specific skill of piloting the aircraft. (BR)

Norris, Don

1974-01-01

144

Disabled Visitor Parking Only  

E-print Network

SOUTHCOLUMBIASTREET 134 1/2 FRANKLIN STREET BUILDING HILL COMMERCIAL BUILDING PORTHOLE EAST FRANKLIN STREET CHAPEL E BRANSO N STREET BUSINESS SCHOOL PARKING DECK KENAN CENTER KENAN- FLAGLER SCHOOL OF BUSINESS DEAN E DR. BAITY LABS PITTSBORO STREET VANCE STREET M cG AVR AN -G R EEN BER G RO SENAU PUBLIC HEALTH SOCIA

North Carolina at Chapel Hill, University of

145

Advice & Regulations for parking  

E-print Network

in the following areas by : Willow, Arden,Avon Road,Avon Building, rear of Lifelong Learning ELIGIBILITY Members of staff, other persons employed on campus, students resident off campus or visitors may park in the Pay REPLACEMENT VEHICLE Staff who have the use of a second vehicle must ensure that the details of the vehicle

Davies, Christopher

146

Yellowstone National Park  

NSDL National Science Digital Library

Yellowstone National Park was established on March 1, 1872, as the first national park in the world. The overwhelming and unique beauty found in this natural wonder is truly difficult to describe.This Topic In Depth begin with the excellent National Park Service's (1) official Yellowstone Web Site, which contains the park's history, virtual field trips, park information, visitor guides, web cams, kids pages, and more. The next site offered by EarthTalk Studios is called Yellowstone Geographic. This extensive and graphically reliant site contains superb interactive activities related to the park and comes close to its goal of being "the best Yellowstone Web Site on the planet." The third site from UnMuseum.org called Weird Geology: Geysers explores the workings of Yellowstone's famous geysers with descriptions, photographs, illustrations, and a movie of an eruption. The next site from Exploratorium is a learning activity called Geyser: Cyclic Hot Water Fountain. With the help of their teacher, students build a working model of a geyser from common chemical equipment. From the University of Michigan, Meg Streepey's Geysers and the Earth's Plumbing Systems Web Site describes (for more advanced students) how geysers work, including how to analyze their thermal and hydrologic regimes. Another research site, from the University of Utah's College of Mines and Earth Sciences, is the GPS Surveys of the Yellowstone Hotspot and the Wasatch Fault, Utah. Objectives of the study are "to measure and understand the spatial and temporal variations of the crustal deformation produced by the interaction between lithospheric plate motion and the asthenospheric hotspot." The last two sites are from the USGS, the first of which is the Yellowstone River Basin National Water-Quality Assessment Program site. It contains a project description, available data, and other relevant information. The last site, Yellowstone Volcano Observatory, is a facility that is designed for observing volcanic and earthquake activity in the park. This site also contains a project description, volcanic data, maps, descriptions of volcanic rock, a frequently asked questions link, and more.

Brieske, Joel A.

2002-01-01

147

Seminal levels of IL-10, IL-12, and IL-17 in men with asymptomatic chlamydia infection.  

PubMed

Chlamydia trachomatis, as an obligate intracellular parasite, usually causes asymptomatic genital tract infections in both men and women with several complications. The role of C. trachomatis infection in the secretion of a number of interleukins (ILs) from epithelial cells has been established by in vitro studies performed on various cell lines. The aim of this study was to detect the seminal levels of IL-10, IL-12, and IL-17 in men with asymptomatic chlamydia infection. Our case group study included 50 semen samples being PCR-positive for C. trachomatis from 585 semen samples and the ELISA method was applied for detection of IL-10, IL-12, and IL-17. Our results demonstrated that the semen levels of IL-10 and IL-17 were significantly increased, while IL-12 was decreased in C. trachomatis-infected patients. According to these results, it may be concluded that the increased and decreased semen levels of IL-10 and IL-12, respectively, lead to impaired immune responses against C. trachomatis. Increased semen levels of IL-17 may also be associated with the pathogenesis of C. trachomatis infection. PMID:23996104

Hakimi, Hamid; Akhondi, Mohammad Mehdi; Sadeghi, Mohammad Reza; Chamani, Leila; Arababadi, Mohammad Kazemi; Ahmadabadi, Behzad Nasiri; Hassanshahi, Gholamhossein; Fathollahi, Mahmoud Sheikh

2014-02-01

148

MYUNGHWAN PARK 6200 Westchester Park Drive, APT 1510, College Park, Maryland 20740  

E-print Network

MYUNGHWAN PARK 6200 Westchester Park Drive, APT 1510, College Park, Maryland 20740 MOBILE : (+1 interested in the analysis of RF coupling on IC circuit. EDUCATION University of Maryland Sep 2008 - May 2013(expected) Ph.D. Candidate in Electrical and Computer Engineering University of Maryland May 2012 M

Lathrop, Daniel P.

149

Mortar Method Using Lagrange Multiplier Applied to the Analysis of Horseshoe-Shaped Waveguide  

NASA Astrophysics Data System (ADS)

The application of the mortar method using Lagrange multiplier to the waveguides is the basic objective of the present paper. The application of the analytical integration technique is made with integrals written in homogeneous coordinates of the finite element. In such a way, the matrices are calculated once, being independent of the element dimensions and dependent only on the type and the order of the used approximation. To confirm, the cutoff wavelengths of the dominant and first high-order mode of the horseshoe-shaped waveguide are calculated.

de Andrade Filho, Moacir Moura; Ricardo Ganime Alves, Plnio

2010-04-01

150

Dependent coordinates in the Lagrange-Poincar equations for mechanical systems with symmetry  

E-print Network

The Lagrange--Poincar\\'e equations for the mechanical system describing the motion of a scalar particle on a Riemannian manifold with a given free and isometric action of a compact Lie group is obtained. In an arising principle fibre bundle, the total space of which serves as a configuration space of the considered mechanical system, the local description of the reduced motion is done in terms of dependent coordinates. In obtaining of the equations we use the variational principle developed by Poincar\\'e for the mechanical systems with a symmetry.

S. N. Storchak

2014-12-30

151

Taylor-Lagrange renormalization scheme, Pauli-Villars subtraction, and light-front dynamics  

SciTech Connect

We show how the recently proposed Taylor-Lagrange renormalization scheme can lead to extensions of singular distributions which are reminiscent of the Pauli-Villars subtraction. However, at variance with the Pauli-Villars regularization scheme, no infinite mass limit is performed in this scheme. As an illustration of this mechanism, we consider the calculation of the self-energy in second order perturbation theory in the Yukawa model, within the covariant formulation of light-front dynamics. We show, in particular, how rotational invariance is preserved in this scheme.

Grange, P.; Mutet, B. [Laboratoire de Physique Theorique et Astroparticules, Universite Montpellier II, CNRS/IN2P3, Place E. Bataillon, F-34095 Montpellier Cedex 05 (France); Mathiot, J.-F. [Clermont Universite, Laboratoire de Physique Corpusculaire, BP10448, F-63000 Clermont-Ferrand (France); Werner, E. [Institut fr Theoretische Physik, Universitt Regensburg, Universittstrasse 31, D-93053 Regensburg (Germany)

2010-07-15

152

The Lagrange Points in a Binary Black Hole System: Applications to Electromagnetic Signatures  

NASA Technical Reports Server (NTRS)

We study the stability and evolution of the Lagrange points L_4 and L-5 in a black hole (BH) binary system, including gravitational radiation. We find that gas and stars can be shepherded in with the BH system until the final moments before merger, providing the fuel for a bright electromagnetic counterpart to a gravitational wave signal. Other astrophysical signatures include the ejection of hyper-velocity stars, gravitational collapse of globular clusters, and the periodic shift of narrow emission lines in AGN.

Schnittman, Jeremy

2010-01-01

153

76 FR 80393 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY: National Park...SUMMARY: The Field Museum of Natural History has completed an inventory of human remains...may contact the Field Museum of Natural History. Repatriation of the human remains...

2011-12-23

154

77 FR 49349 - Safety Zone; Chicago Air and Water Show, Lake Michigan, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Zone; Chicago Air and Water Show, Lake Michigan, Chicago, IL AGENCY: Coast Guard...Air and Water Show safety zone on Lake Michigan near Lincoln Park. This action is necessary...restrict vessels from a portion of Lake Michigan during the Chicago Air and Water...

2012-08-16

155

Volumetric Displacement Effects In Euler-Lagrange Simulations of Sediment-Laden Oscillatory Flows  

NASA Astrophysics Data System (ADS)

An improved, three-dimensional approach for Euler-Lagrange simulation of sediment-laden oscillatory turbulent flows is developed. In this approach, the sediment particles are unresolved and subgrid similar to a discrete element model (DEM), however, the fluid volume (mass) displaced by the particle is accounted for in the conservation equations. Recent Euler-Lagrange modeling of a few microbubbles entrained in a traveling vortex ring (Cihonski et al., JFM, 2013) has shown that extension of the standard point-particle DEM method to include local volume displacement effects is critical in capturing vortex distortion effects due to microbubbles, even in a very dilute suspension. We extend this approach to investigate particle-laden oscillatory boundary layers representative of coastal sediment environments. A wall bounded, doubly periodic domain is considered laden with a layer of sediment particles in laminar as well as turbulent oscillatory boundary layers corresponding to the experiments of Keiller and Sleath (1987) and Jensen et al. (1987). Inter-particle and particle-wall collisions are modeled using a soft-sphere model which uses a nested collision grid to minimize computational effort. The effects of fluid mass displaced by the particles on the flow statistics are quantified by comparing a standard two-way coupling approach (without volume displacement effects) with volume displacement effects to show that the latter models are important for cases with low specific gravity.

Apte, S.; Finn, J. R.; Cihonski, A.

2013-12-01

156

Augmented Lagrange Hopfield network for solving economic dispatch problem in competitive environment  

NASA Astrophysics Data System (ADS)

This paper proposes an augmented Lagrange Hopfield network (ALHN) for solving economic dispatch (ED) problem in the competitive environment. The proposed ALHN is a continuous Hopfield network with its energy function based on augmented Lagrange function for efficiently dealing with constrained optimization problems. The ALHN method can overcome the drawbacks of the conventional Hopfield network such as local optimum, long computational time, and linear constraints. The proposed method is used for solving the ED problem with two revenue models of revenue based on payment for power delivered and payment for reserve allocated. The proposed ALHN has been tested on two systems of 3 units and 10 units for the two considered revenue models. The obtained results from the proposed methods are compared to those from differential evolution (DE) and particle swarm optimization (PSO) methods. The result comparison has indicated that the proposed method is very efficient for solving the problem. Therefore, the proposed ALHN could be a favorable tool for ED problem in the competitive environment.

Vo, Dieu Ngoc; Ongsakul, Weerakorn; Nguyen, Khai Phuc

2012-11-01

157

How to zoom: bias, contamination and Lagrange volumes in multimass cosmological simulations  

NASA Astrophysics Data System (ADS)

We perform a suite of multimass cosmological zoom simulations of individual dark matter haloes and explore how to best select Lagrangian regions for resimulation without contaminating the halo of interest with low-resolution particles. Such contamination can lead to significant errors in the gas distribution of hydrodynamical simulations, as we show. For a fixed Lagrange volume, we find that the chance of contamination increases systematically with the level of zoom. In order to avoid contamination, the Lagrangian volume selected for resimulation must increase monotonically with the resolution difference between parent box and the zoom region. We provide a simple formula for selecting Lagrangian regions (in units of the halo virial volume) as a function of the level of zoom required. We also explore the degree to which a halo's Lagrangian volume correlates with other halo properties (concentration, spin, formation time, shape, etc.) and find no significant correlation. There is a mild correlation between Lagrange volume and environment, such that haloes living in the most clustered regions have larger Lagrangian volumes. Nevertheless, selecting haloes to be isolated is not the best way to ensure inexpensive zoom simulations. We explain how one can safely choose haloes with the smallest Lagrangian volumes, which are the least expensive to resimulate, without biasing one's sample.

Oorbe, Jose; Garrison-Kimmel, Shea; Maller, Ariyeh H.; Bullock, James S.; Rocha, Miguel; Hahn, Oliver

2014-01-01

158

Bike parking LEEGHWATERSTRAATDREBBELWEG  

E-print Network

Stork - B.3 L Huub van Doorne - B.2 R Emile Truijen - A.0 S Bernd Schierbeek - D.1 T Joost van der PARKING CARPARKING CARPARKING CARPARKING EH E CA A D E B C AD H K L J G G F F F B C Lecture roomsStudy places Facilities Services laboratories Departments Levels A Leonardo da Vinci - A.0 B Isaac Newton - A.0

Lindken, Ralph

159

The energy Park  

NASA Astrophysics Data System (ADS)

If world development is to continue, per capita energy use in the developing world must increase to levels in the developed world. Restrictions on how much CO2 mankind can responsibly put into the atmosphere complicate the task further. Studies show that by 2050 the world will require an additional 10-30 terawatts (TW) of carbon free power, at least as much additional, as the 10 TW generated today with fossil fuel. Neither mined uranium nor renewable energy is capable of sustained power production at this level. This paper proposes, an "energy park", a self contained unit a square mile or two in area which supplies about 7 GW of electrical power or hydrogen, emits no CO2, has little or no proliferation problem, and cleans up its own waste. Most of the energy is supplied by conventional nuclear power plants. However the nuclear fuel is bred by a fusion reactor, which is the key to the energy park. The waste cleanup is done by a combination of fission, fusion, and patience. There is neither long time storage nor long distance travel for materials with proliferation risk or long lived radio nuclides. Thus only thorium comes into the park, and only electricity and hydrogen go out.

Manheimer, Wallace

2005-10-01

160

Fruit and Spice Park Park n r a n  

E-print Network

1 Fruit and Spice Park Park n r a n 24801 S.W. 187th Avenue Homestead, Florida 33031 Main: 305 of the Redland is a non-pro t group formed to promote exo c fruits and the Miami- ade Count Fruit & Spice Park. The Societ originated in 1981 when a small group of enthusiasts egan mee ng regularl at the Fruit & Spice

Koptur, Suzanne

161

East Tennessee Technology Park 3-1 3. East Tennessee Technology Park  

E-print Network

East Tennessee Technology Park 3-1 3. East Tennessee Technology Park ETTP was originally built to the East Tennessee Technology Park. Environmental management and remediation operations consist the "East Tennessee Technology Park" to

Pennycook, Steve

162

Canyonlands National Park, UT, USA  

NASA Technical Reports Server (NTRS)

Desert and mountain scenery along the Utah/Colorado border are displayed in this scene of the Canyonlands National Park, UT (39.0N, 110.0W). The park occupies the near center of the image, displaying spectacular incised meanders and the bulls-eye structure of Upheaval Dome (a salt dome). The Green River and the Colorado River flow southward to join (off scene) before flowing through the Grand Canyon National Park.

1973-01-01

163

Canyonlands National Park, UT, USA  

NASA Technical Reports Server (NTRS)

Desert and mountain scenery along the Utah/Colorado border are displayed in this scene of the Canyonlands National Park, UT (39.0N, 110.0W). The Park occuppies the near center of the image, displaying spectacular incised meanders and the bulls-eye structure of Upheaval Dome (a salt dome). The Green River and the Colorado River flow southward to join off scene before flowing through the Grand Canyon National Park.

1992-01-01

164

Changwon Park Postdoc Research Associates  

E-print Network

structure and phase transition of (GeTe)n(Sb 2Te3)m used for phase-change memory" Im, J., Eom, J.-H., Park for a phase-change memory device" Eom, J.-H., Yoon, Y.-G., Park, C., Lee, H., Im, J., Suh, D.-S., Noh, J transport in carbon nanotubes" Eom, J.-H., Lee, H., Im, J., Park, C., Wook Jeong, B., Kim, S., Ihm, J

Pennycook, Steve

165

National Parks WebQuest  

NSDL National Science Digital Library

This web-based activity challenges students to use a variety of internet resources to learn about several dimensions of national parks. Each student's research assignment focuses on one component of a park, such as its history, biology, geology, or tourist appeal. Students must keep track of important points and their references. Once research is complete, students come together and teach each other about their specific research domain, culminating in a holistic understanding of the park features.

Mrs. Phillip

166

Hawaii hydrogen power park Hawaii Hydrogen Power Park  

E-print Network

& learning channel cable TV. #12;Hawaii hydrogen power park H Technology Transfer/Collaborations California Demonstrate an integrated Hydrogen Power Park comprised of the following: Electrolyzer powered by a renewable on hydrogen technologies. (Barrier S­Siting) Economic analysis of hydrogen infrastructure using actual data

167

PARKING FACILITY PROJECTIONS BASED ON THE 1968 STUDENT PARKING SURVEY.  

ERIC Educational Resources Information Center

RESPONSES FROM 1,309 STUDENTS AND 121 CAMPUS EMPLOYEES AT CUYAHOGA COMMUNITY COLLEGE WERE USED TO PROJECT REQUIREMENTS FOR PARKING FACILITIES AT THE INSTITUTION BY 1971. STUDENTS INDICATED WHETHER OR NOT THEY CURRENTLY DROVE TO SCHOOL AND, IF NOT, IF THEY WOULD INTEND TO DRIVE IF PARKING FACILITIES WERE PROVIDED AT A NOMINAL FEE. FINDINGS SHOWED

DALBY, J. PHILIP; KENDRA, LAWRENCE M.

168

Application of the Lagrange-Souriau form method to the case of source-free electromagnetic field  

E-print Network

The recent method of the description of classical fields in terms of Lagrange-Souriau form is applied to the case of source-free electromagnetic field in order to check its computational capabilities. The relevant calculations are represented in all details and yield a useful data for comparisons of the method with more usual approaches in this simple and transparent case.

S. Tertychniy

1993-12-29

169

Design of multichannel DWDM fiber Bragg grating filters by Lagrange multiplier constrained optimization.  

PubMed

We present the synthesis of multi-channel fiber Bragg grating (MCFBG) filters for dense wavelength-division-multiplexing (DWDM) application by using a simple optimization approach based on a Lagrange multiplier optimization (LMO) method. We demonstrate for the first time that the LMO method can be used to constrain various parameters of the designed MCFBG filters for practical application demands and fabrication requirements. The designed filters have a number of merits, i.e., flat-top and low dispersion spectral response as well as single stage. Above all, the maximum amplitude of the index modulation profiles of the designed MCFBGs can be substantially reduced under the applied constrained condition. The simulation results demonstrate that the LMO algorithm can provide a potential alternative for complex fiber grating filter design problems. PMID:19529515

Lee, Cheng-Ling; Lee, Ray-Kuang; Kao, Yee-Mou

2006-11-13

170

Design of multichannel DWDM fiber Bragg grating filters by Lagrange multiplier constrained optimization  

NASA Astrophysics Data System (ADS)

We present the synthesis of multi-channel fiber Bragg grating (MCFBG) filters for dense wavelength-division-multiplexing (DWDM) application by using a simple optimization approach based on a Lagrange multiplier optimization (LMO) method. We demonstrate for the first time that the LMO method can be used to constrain various parameters of the designed MCFBG filters for practical application demands and fabrication requirements. The designed filters have a number of merits, i.e., flat-top and low dispersion spectral response as well as single stage. Above all, the maximum amplitude of the index modulation profiles of the designed MCFBGs can be substantially reduced under the applied constrained condition. The simulation results demonstrate that the LMO algorithm can provide a potential alternative for complex fiber grating filter design problems.

Lee, Cheng-Ling; Lee, Ray-Kuang; Kao, Yee-Mou

2006-11-01

171

Variational principles for reactive collisions based on the generalized Lagrange multiplier method  

NASA Astrophysics Data System (ADS)

In this study is discussed a general approach to derive variational principles for physical magnitudes Q(?) which are dependent on functions ? known to be solutions of physical equations [see Gerjuoy et al., Rev. Mod. Phys. 55, 725 (1983)]. The approach is based on Lagrange multipliers which are incorporated into the expression for calculating Q by demanding that the functions ? fulfill their equations. This approach is first applied to derive a general variational principle for the T-matrix elements based on the Lippmann-Schwinger equation. As special cases we obtained the bilinear forms of the Schwinger and the Newton variational principles. Next this approach is employed to derive a new Kohn-type variational principle for the S-matrix elements for reactive collisions based on the Schrdinger equation which contains complex potentials. Finally, this approach is further utilized to derive a novel variational principle for the flux function.

Baer, Michael; Nakamura, Hiroki

1992-05-01

172

Testing of Lagrange multiplier damped least-squares control algorithm for woofer-tweeter adaptive optics  

PubMed Central

A Lagrange multiplier-based damped least-squares control algorithm for woofer-tweeter (W-T) dual deformable-mirror (DM) adaptive optics (AO) is tested with a breadboard system. We show that the algorithm can complementarily command the two DMs to correct wavefront aberrations within a single optimization process: the woofer DM correcting the high-stroke, low-order aberrations, and the tweeter DM correcting the low-stroke, high-order aberrations. The optimal damping factor for a DM is found to be the median of the eigenvalue spectrum of the influence matrix of that DM. Wavefront control accuracy is maximized with the optimized control parameters. For the breadboard system, the residual wavefront error can be controlled to the precision of 0.03 ?m in root mean square. The W-T dual-DM AO has applications in both ophthalmology and astronomy. PMID:22441462

Zou, Weiyao; Burns, Stephen A.

2012-01-01

173

Consensus of Euler-Lagrange Systems Networked by Sampled-Data Information with Probabilistic Time Delays.  

PubMed

This paper investigates the consensus problem of multiple Euler-Lagrange systems under directed topology. Unlike the common assumptions on continuous-time information exchanges, a more realistic sampled-data communication strategy is proposed with probabilistic occurrence of time-varying delays. Both of the sampling period and the delays are assumed to be time-varying, which is more general in some practical situations. In addition, the relative coordinate derivative information is not required in the distributed controllers such that the communication network burden can be further reduced. In particular, a distinct feature of the proposed scheme lies in the fact that it can effectively reduce the energy consumption. By employing the stochastic analysis techniques, sufficient conditions are established to guarantee that the consensus can be achieved. Finally, a numerical example is provided to illustrate the applicability and benefits of the theoretical results. PMID:25148678

Ma, Chao; Shi, Peng; Zhao, Xudong; Zeng, Qingshuang

2014-08-19

174

C1 hierarchical Riesz bases of Lagrange type on Powell-Sabin triangulations  

NASA Astrophysics Data System (ADS)

In this paper we construct C1 continuous piecewise quadratic hierarchical bases on Powell-Sabin triangulations of arbitrary polygonal domains in . Our bases are of Lagrange type instead of the usual Hermite type and under some weak regularity assumptions on the underlying triangulations we prove that they form strongly stable Riesz bases for the Sobolev spaces Hs([Omega]) with s[set membership, variant](1,5/2). Especially the case s=2 is of interest, because we can use the corresponding hierarchical basis for preconditioning fourth-order elliptic equations leading to uniformly well-conditioned stiffness matrices. Compared to the hierarchical Riesz bases by Davydov and Stevenson (Hierarchical Riesz bases for Hs([Omega]), 1s. Constructive Approximation, to appear) our construction is simpler.

Maes, Jan; Bultheel, Adhemar

2006-11-01

175

Mesoscale Simulations of Particulate Flows with Parallel Distributed Lagrange Multiplier Technique  

SciTech Connect

Fluid particulate flows are common phenomena in nature and industry. Modeling of such flows at micro and macro levels as well establishing relationships between these approaches are needed to understand properties of the particulate matter. We propose a computational technique based on the direct numerical simulation of the particulate flows. The numerical method is based on the distributed Lagrange multiplier technique following the ideas of Glowinski et al. (1999). Each particle is explicitly resolved on an Eulerian grid as a separate domain, using solid volume fractions. The fluid equations are solved through the entire computational domain, however, Lagrange multiplier constrains are applied inside the particle domain such that the fluid within any volume associated with a solid particle moves as an incompressible rigid body. Mutual forces for the fluid-particle interactions are internal to the system. Particles interact with the fluid via fluid dynamic equations, resulting in implicit fluid-rigid-body coupling relations that produce realistic fluid flow around the particles (i.e., no-slip boundary conditions). The particle-particle interactions are implemented using explicit force-displacement interactions for frictional inelastic particles similar to the DEM method of Cundall et al. (1979) with some modifications using a volume of an overlapping region as an input to the contact forces. The method is flexible enough to handle arbitrary particle shapes and size distributions. A parallel implementation of the method is based on the SAMRAI (Structured Adaptive Mesh Refinement Application Infrastructure) library, which allows handling of large amounts of rigid particles and enables local grid refinement. Accuracy and convergence of the presented method has been tested against known solutions for a falling sphere as well as by examining fluid flows through stationary particle beds (periodic and cubic packing). To evaluate code performance and validate particle contact physics algorithm, we performed simulations of a representative experiment conducted at the University of California at Berkley for pebble flow through a narrow opening.

Kanarska, Y

2010-03-24

176

Designing for ecology : the ecological park  

E-print Network

This thesis aims to define a) what an ecological park is, and b) whether it is a new model in park design. Reference to the literature on landscape ecology is used to analyze the natural ecological merit of these parks, ...

Power, Andres M

2006-01-01

177

Stroke, IL-1ra, IL1RN, Infection and Outcome  

PubMed Central

Background Infection is common following stroke and adversely affects outcome. Previous studies suggest that interleukin-1 receptor antagonist (IL-1ra) and single nucleotide polymorphisms (SNPs) in the IL1RN gene might influence the risk of post-stroke infection and outcome. In this study, we addressed the effects of the rs4251961 SNP in IL1RN on infection risk and outcome. Methods Subjects with acute ischemic stroke were enrolled within 72 hours of symptom onset and followed up to one year. Plasma IL-1ra was measured at multiple time points and outcome assessed at 1, 3, 6, and 12 months. Active surveillance for infection occurred while subjects were hospitalized. Subjects were genotyped for the IL1RN rs4251961 polymorphism. Results In this population of 113 subjects, those with the minor C allele of rs4251961 polymorphism in IL1RN were more likely to be Caucasian, hypertensive and to have coronary heart disease. Higher plasma IL-1ra was associated with an increased risk of infection (other than pneumonia) and the minor C allele of rs4251961 was independently associated with a decreased risk of infection (other than pneumonia). Initial plasma IL-1ra was not predictive of long term outcome, but patients with the minor C allele of rs4251961 were more likely to experience good (modified Rankin Score <2) long-term outcome. Conclusions These data indicate that IL-1ra and IL1RN may influence the risk of infection after stroke, but this influence seems limited to infections other than pneumonia. Further studies are needed to better understand the complexities of immune regulation on infection and outcome after stroke. PMID:24233813

Becker, Kyra J.; Dankwa, Dorender; Lee, Richard; Schulze, Juliane; Zierath, Dannielle; Tanzi, Patricia; Cain, Kevin; Dressel, Alexander; Shibata, Dean; Weinstein, Jonathan

2014-01-01

178

Geology Fieldnotes: Petrified Forest National Park, Arizona  

NSDL National Science Digital Library

Petrified Forest National Park was established to preserve large deposits of petrified wood and to prevent removal of the wood by the public. Site featues include park geology information, maps, photographs, related links, visitor information, multimedia resources, and resources for teaching geology with National Park examples. The park geology section discusses the park's geologic history, structural geology, petrified wood, and dinosaur fossils. The maps section includes a map of the park itself and the surrounding area.

179

Young Eun Park Vanderbilt University  

E-print Network

1 Young Eun Park Vanderbilt University Department of Psychology 111 21st Ave South 301 Wilson Hall Nashville, TN 37240 (615) 322-2835 youngeun.park@vanderbilt.edu EDUCATION 2004 ­ 2009 Korea University, Seoul, Korea B.A. in Psychology Advisor: Dr. Yang Seok Cho 2009 ­ 2011 Korea University, Seoul, Korea M

Tong, Frank

180

Microbiology in Yellowstone National Park  

NSDL National Science Digital Library

This site describes how Yellowstone National Park is a focal point for cutting-edge microbiology research and how it provides a valuable setting for outreach education. Topics include questions for park officials, extremophiles, microbe diversity and evolution, educational outreach, and suggested reading.

Ward David

181

National Park Service Geologic Resources  

NSDL National Science Digital Library

This collection of images shows geologic features in many of the country's national parks. The collection is searchable by park name, state, year, or by the name of the photograph. Each photo is accompanied by a brief caption that provides the photographer's name, the date, and a description of the photo.

182

HOURGLASS FIRE Pingree Park Vicinity  

E-print Network

HOURGLASS FIRE Pingree Park Vicinity July 1-July 7, 1994 P.N. Omi Pingree Park overview, September, 1994, showing campus facilities in relation to area burned in the Houglass Fire. Summary narrative: The Hourglass Fire was first reported via 911 call to the Larimer County Sheriff on Friday, July 1 1994 at 10

183

Nevada Division of State Parks  

NSDL National Science Digital Library

Based in Carson City, the Nevada Division of State Parks helps to preserve and promote notable parts of the Nevada natural and cultural environment. One of the goals of their website is to provide visitors with "an introduction to the other side of Nevada, the side that is wild scenic and full of western history." First-time visitors may wish to click on the "State parks map" area to learn more about the location of the state parks, and the interactive map also includes direct links to each site. Scholars and students of park management will want to click on over to the "Park General and Resource Management Plans" area. Here they can learn about the completed general management plans for parks such as the Mormon Station and the Valley of Fire, and learn about plans that are currently under review. Visitors looking for helpful information about upcoming events can look over the "Other Park News!" area on the right hand side of the homepage. Finally, there's also detailed information about park fees, several photo galleries, and news releases.

184

Directions & Parking for Engineering Plaza  

E-print Network

the toll road begins) and turn left onto Bison. Turn right onto East Peltason. Turn left at Anteater Drive into Anteater Parking Structure. Exit structure by foot to East Peltason and follow pedestrian Campus Drive. Turn right onto East Peltason. Turn right at Anteater Drive into Anteater Parking

Loudon, Catherine

185

Study on public parking problems and countermeasures  

NASA Astrophysics Data System (ADS)

With the rapid growth of motorization, public parking has become a distinct problem influences urban development and people's life quality. Unscientific method of urban planning and lagging of related studies lead to parking problem becoming more and more seriously day by day. The propose of this paper is to put forward several solutions for public parking problem, including parking management policies, building with construction parking policies, regional differentiation policy, parking industrial policy, self-parking policy and so on, from the point of regulatory plan and related policy. It is significant to guide new urban areas construction and improve the parking situation.

Hu, Hongbing; Wen, Zhaokang

2011-12-01

186

Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases  

PubMed Central

T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-? and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases. PMID:23956763

Qu, Ning; Xu, Mingli; Mizoguchi, Izuru; Furusawa, Jun-ichi; Kaneko, Kotaro; Watanabe, Kazunori; Mizuguchi, Junichiro; Itoh, Masahiro; Kawakami, Yutaka; Yoshimoto, Takayuki

2013-01-01

187

Lincoln Park Neighborhood Collection  

NSDL National Science Digital Library

Today, the Lincoln Park neighborhood on Chicago's North Side is a relatively affluent area, complete with Victorian mansions and rather tony elevator apartment buildings. By the late 1940s, the area was experiencing the same type of urban disinvestment as other inner-city neighborhoods throughout the United States. In the early 1960s, the city of Chicago, working with funds from the federal government, began an ambitious urban renewal program designed to reduce the density of the built environment in the community and to remove "blighted" properties. This excellent collection from the DePaul University Libraries Digital Collections contains over 400 documents related to this ambitious project, including maps, zoning documents, policy statements, neighborhood organization planning documents, and photographs. First-time visitors may wish to start with the first document here, "A Brief Explanation of the Urban Community Conservation Act." Moving on, visitors can view the rest of the documents by title, thumbnail, subject, and brief description.

188

Chicago Public Library: Millennium Park  

NSDL National Science Digital Library

The transformation of the area east of Michigan Avenue from an industrial wasteland into the vibrant and heavily-used Millennium Park is truly a remarkable tale in Chicago's recent history. The apocryphal tale says that Mayor Richard M. Daley looked out from his dentist's office and envisioned a public park that would be comparable to other grand spaces in the city. The construction of Millennium Park took quite some time, but when the park was finished in 2004, most people were quite happy with it. This digital collection from the Chicago Public Library brings together over 5,100 images of the park at various phases of its construction. Visitors can view a highlights file of 154 images, and they can wander through topical areas like Cloud Gate, Crown Fountain, and Lurie Garden. Visitors interested in broad vistas of the entire setting should click on Full Park. Finally, visitors can use the tabs on the left-hand side of the page to look at architectural renderings and models of the park's various sections.

2012-03-16

189

Perception of urban park soundscape.  

PubMed

A number of studies have been initiated to explore how to improve the soundscape quality in urban parks. However, good soundscape quality in parks cannot be provided without a thorough understanding of the complex relationships among sound, environment, and individuals. As acoustic comfort is considered to be an important outcome of soundscape quality, this study investigates the relative impacts of the factors influencing acoustic comfort evaluation by formulating a multivariate ordered logit model. This study also explores the inter-relationships among acoustic comfort evaluation, acceptability of the environment, and preference to stay in a park using a path model. A total of 595 valid responses were obtained from interview surveys administered in four parks in Hong Kong while objective sound measurements were carried out at the survey spots concurrently. The findings unveil that acoustic comfort evaluation, besides visual comfort evaluation of landscape, also plays an important role on users' acceptability of the urban park environment. Compared with all the studied acoustic related factors, acoustic comfort evaluation serves as a better proxy for park users' preference to stay in urban parks. Hearing the breeze will significantly increase the likelihood of individuals in giving high acoustic comfort evaluation. Conversely, hearing the sounds from heavy vehicles or sounds from bikes will significantly reduce the likelihood in giving a high acoustic evaluation. PMID:22501055

Tse, Man Sze; Chau, Chi Kwan; Choy, Yat Sze; Tsui, Wai Keung; Chan, Chak Ngai; Tang, Shiu Keung

2012-04-01

190

Aftermath of Griffith Park Fire  

NASA Technical Reports Server (NTRS)

In mid-May 2007, wind-driven flames raced through Griffith Park in Los Angeles, forcing hasty evacuations and threatening numerous famous landmarks and tourist spots, such as the Los Angeles Zoo and the Hollywood Sign. Ultimately, no one was injured in the fire, which may have been started by a cigarette. About 800 acres burned in the urban park, which is itself a Hollywood landmark, having been the location for several movies, including Rebel Without A Cause. This image of the park was captured by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite on June 6, 2007, about a month after the fire. ASTER detects both visible and infrared wavelengths of light, and both kinds have been used to make this image. Vegetation appears in various shades of red, while the burned areas appear charcoal. Roads and dense urban areas appear purplish-gray or white. Water is dark blue. Large burned areas are evident in the northwest and southeast parts of the park, with scattered smaller patches along the southern margin. Some botanical gardens and parts of a bird sanctuary, as well as some park structures like restrooms, were destroyed. The park's unburned, natural vegetation appears brick red, while the irrigated golf courses adjacent to the park are bright red. NASA image created by Jesse Allen, using data provided courtesy of the NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.

2007-01-01

191

Park and chill : redesign parking garage in Hong Kong  

E-print Network

What are the aesthetics of urban infrastructure? Urban infrastructure has remained isolated to human activities. We all share memory and experience with urban infrastructure, e.g. we drive on the same roads and park our ...

Ting, Sze Ngai

2011-01-01

192

1.OA At the Park  

NSDL National Science Digital Library

This is a task from the Illustrative Mathematics website that is one part of a complete illustration of the standard to which it is aligned. Each task has at least one solution and some commentary that addresses important asects of the task and its potential use. Here are the first few lines of the commentary for this task: There were 7 children at the park. Then 4 more showed up. How many children were at the park all together? There were 7 children at the park. Some more...

193

Yellowstone National Park: Historic 3-D Photographs Featuring Park Geology  

NSDL National Science Digital Library

This source provides a series of 34 historic photographs of well-known geologic landmarks in Yellowstone National Park. The photographs can be viewed individually or as part of a tour that begins at Old Faithful and proceeds in a clockwise route around the park. The images were created by digital manipulation of antique stereographs and they may be viewed as black and white photos or in 3-D using special stereographic glasses.

Stoffer Phil

194

Man Sik Park Symmetry and Separability In  

E-print Network

Man Sik Park Symmetry and Separability In Spatial-Temporal Processes Man Sik Park, Montserrat Fuentes Symmetry and Separability In Spatial-Temporal Processes 1 #12;Man Sik Park Motivation · In general-pollution data. Symmetry and Separability In Spatial-Temporal Processes 2 #12;Man Sik Park Research Objectives 1

195

The impact of federal revenue sharing on recreation and parks in Texas  

E-print Network

THE IMPACT OF FEDERAL REVFNUE SHARINO ON RECRFATION AViD PARKS IN TEXAS 4 Thesis SYDNEY HENRY VERINDER Submitted to the Graduate Coj le?e of' Texas ASM University in partial fulfillment of the requirement for the degree of MASTER OF SCIENCE... December 1974 Major Subject& Recreation and Resources Development THE Il&PACT OF FEDERAL REVENUE SHARING ON RECREATION AND PARKS IN TEXAS A Thesis by SYDNEY HENRY VERINDER Approved as to style and content by: ai . an of' Committee . ead...

Verinder, Sydney Henry

1974-01-01

196

Parking Citation Appeal UVA Parking and Transportation, P.O. Box 400000, Charlottesville, Va. 229044000  

E-print Network

Parking Citation Appeal UVA Parking and Transportation, P.O. Box 400000.virginia.edu/parking UNACCEPTABLE GROUNDS FOR APPEAL ARE: Parking for SHORT periods, parking in a nearly empty lot, not knowing regulations, not seeing the signs. *If you appeal to the Traffic Appeals Committee, please note

Acton, Scott

197

IL-1 receptor 2 (IL-1R2) and its role in immune regulation  

PubMed Central

The cytokine IL-1 is critical to the pathogenesis of a variety of human conditions and diseases. Unlike most other cytokines, IL-1 is counterbalanced by two endogenous inhibitors. The functional significance of IL-1 receptor antagonist (IL-1RA) is well documented due to the clinical utilization of the recombinant human IL-1RA analog, anakinra. In contrast, much less is known about the type 2 IL-1 receptor (IL-1R2), which acts as a decoy receptor for IL-1. While IL-1R2 is structurally similar to the type 1 IL-1 receptor (IL-1R1) responsible for IL-1 signal transduction, its truncated cytoplasmic domain and lack of Toll-IL-1 receptor (TIR) region renders IL-1R2 incapable of transmembrane signaling. IL-1R2 competes with IL-1R1 for ligands and for the IL-1R1 co-receptor, IL-1 receptor accessory protein (IL-1RAP). Additionally, IL-1R2 exists in both a membrane bound and soluble form (sIL-1R2) that has biological properties similar to both a decoy receptor and a binding protein. Thus far, IL-1R2 has been implicated in arthritis, endometriosis, organ transplantation, sepsis/sickness behavior, diabetes, atherosclerosis, autoimmune inner ear disease (AIED), Alzheimers disease and ulcerative colitis. In this review, we will detail the functional properties of IL-1R2 and examine its role in human disease. PMID:23195532

Peters, Vanessa A.; Joesting, Jennifer J.; Freund, Gregory G.

2012-01-01

198

Morris Park Ave Rhinelander Ave  

E-print Network

Albert Einstein College of Medicine ALBERT EINSTEIN COLLEGE OF MEDICINE JACK AND PEARL RESNICK CAMPUS Building 19. Einstein Boiler Plant JACOBI MEDICAL CENTER 20. Nurses' Residence MEDICAL PARK EINSTEIN PROGRAM LOCATIONS Glass Building Ob/Gyn Private Practice

Kenny, Paraic

199

A Lagrange-multiplier-based XFEM to solve pressure Poisson equations in problems with quasi-static interfaces  

NASA Astrophysics Data System (ADS)

The XFEM (extended finite element method) has a lot of advantages over other numerical methods to resolve discontinuities across quasi-static interfaces due to the jump in fluidic parameters or surface tension. However, singularities corresponding to enriched degrees of freedom (DOFs) embedded in XFEM arise in the discrete pressure Poisson equations. In this paper, constraints on these DOFs are derived from the interfacial equilibrium condition and introduced in terms of stabilized Lagrange multipliers designed for non-boundary-fitted meshes to address this issue. Numerical results show that the weak and strong discontinuities in pressure with straight and circular interfaces are accurately reproduced by the constraints. Comparisons with the SUPG/PSPG (streamline upwind/pressure stabilizing Petrov-Galerkin) method without Lagrange multipliers validate the applicability and flexibility of the proposed constrained algorithm to model problems with quasi-static interfaces.

Liao, JianHui; Zhuang, Zhuo

2012-04-01

200

Increasing the biological activity of IL-2 and IL-15 through complexing with anti-IL-2 mAbs and IL-15R?-Fc chimera.  

PubMed

IL-2 and IL-15 are structurally relative cytokines that share two receptor subunits, CD132 (?(c) chain) and CD122 (? chain). However, the expression pattern and physiological role of IL-2 and IL-15 private receptor ? chains CD25 and IL-15R?, respectively, are strikingly different. CD25, together with CD122 and CD132, forms a trimeric high affinity IL-2 receptor that is expressed and functions on cells acquiring an IL-2 signal. Conversely, IL-15R? is expressed and binds IL-15 with high affinity per se already in the endoplasmic reticulum of the IL-15 producing cells and it presents IL-15 to cells expressing CD122/CD132 dimeric receptor in trans. Thus, while IL-2 is secreted almost exclusively by activated T cells and acts as a free molecule, IL-15 is expressed mostly by myeloid cells and works as a cell surface-associated cytokine. Interestingly, the in vivo biological activity of IL-2 can be dramatically increased through complexing with certain anti-IL-2 mAbs; such IL-2/anti-IL-2 mAbs immunocomplexes selectively stimulate the proliferation of a distinct population of immune cells, depending on the clone of the anti-IL-2 mAb used. IL-2/S4B6 mAb immunocomplexes are highly stimulatory for CD122(high) populations (memory CD8(+) T and NK cells) and intermediately also for CD25(high) populations (Treg and activated T cells), while IL-2/JES6-1 mAb immunocomplexes enormously expand only CD25(high) cells. Although IL-2 immunocomplexes are much more potent than IL-2 in vivo, they show comparable to slightly lower activity in vitro. The in vivo biological activity of IL-15 can be dramatically increased through complexing with recombinant IL-15R?-Fc chimera; however, IL-15/IL-15R?-Fc complexes are significantly more potent than IL-15 both in vivo and in vitro. In this review we summarize and discuss the features and biological relevance of IL-2/anti-IL-2 mAbs and IL-15/IL-15R?-Fc complexes, and try to foreshadow their potential in immunological research and immunotherapy. PMID:24512738

Votavova, Petra; Tomala, Jakub; Kovar, Marek

2014-01-01

201

Arches National Park - Nature and Science  

NSDL National Science Digital Library

This National Park Service (NPS) website highlights the natural resources of Arches National Park, in addition to the sandstone arches for which the park is famous. Details about the park include the animals that inhabit the area (amphibians, birds, mammals and reptiles), natural features (deserts, geologic formations, pools, potholes and soils), environmental factors facing the park (invasive species, perigrine falcons, bighorn sheep), and plants (cacti, grasses, lichens, mosses, liverworts, trees, shrubs and wildflowers).

202

A Lagrange-D'Alembert formulation of the equations of motion of a helicopter carrying an externally suspended load  

NASA Technical Reports Server (NTRS)

The exact nonlinear equations of motion are derived for a helicopter with an extenal load suspended by fore and aft, rigid-link cables. Lagrange's form of D'Alembert's principle is used. Ten degrees of freedom are necessary to represent the motion of this system in an inertial reference frame: six for the helicopter relative to inertial space and four for the load relative to the helicopter.

Weber, J. M.; Greif, R. K.

1985-01-01

203

PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophages.  

PubMed

Leprosy is a persistent infectious disease caused by Mycobacterium leprae that still affects over 200,000 new patients annually. The host genetic background is an important risk factor for leprosy susceptibility and the PARK2 gene is a replicated leprosy susceptibility candidate gene. The protein product of PARK2, Parkin, is an E3 ubiquitin ligase that is involved in the development of various forms of Parkinsonism. The human macrophage is both a natural host cell of M. leprae as well as a primary mediator of natural immune defenses, in part by secreting important pro-inflammatory cytokines and chemokines. Here, we report that down-regulation of Parkin in THP-1 macrophages, human monocyte-derived macrophages and human Schwann cells resulted in a consistent and specific decrease in interleukin-6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1/CCL2) production in response to mycobacteria or LPS. Interestingly, production of IL-6 at 6 hours by THP-1 cells stimulated with live M. leprae and M. bovis BCG was dependent on pretreatment with 1,25-dihydroxyvitamin D(3) (VD). Parkin knockdown in VD-treated cells blocked IL-6 induction by mycobacteria. However, I?B-? phosphorylation and levels of I?B-?, a nuclear protein required for IL-6 expression, were not affected by Parkin silencing. Phosphorylation of MAPK ERK1/2 and p38 was unaffected by Parkin silencing while JNK activation was promoted but did not explain the altered cytokine production. In a final set of experiments we found that genetic risk factors of leprosy located in the PARK2 promoter region were significantly correlated with M. leprae sonicate triggered CCL2 and IL6 transcript levels in whole blood assays. These results associated genetically controlled changes in the production of MCP-1/CCL2 and IL-6 with known leprosy susceptibility factors. PMID:23350010

de Lsleuc, Louis; Orlova, Marianna; Cobat, Aurelie; Girard, Manon; Huong, Nguyen Thu; Ba, Nguyen Ngoc; Thuc, Nguyen Van; Truman, Richard; Spencer, John S; Adams, Linda; Thai, Vu Hong; Alcais, Alexandre; Schurr, Erwin

2013-01-01

204

PARK2 Mediates Interleukin 6 and Monocyte Chemoattractant Protein 1 Production by Human Macrophages  

PubMed Central

Leprosy is a persistent infectious disease caused by Mycobacterium leprae that still affects over 200,000 new patients annually. The host genetic background is an important risk factor for leprosy susceptibility and the PARK2 gene is a replicated leprosy susceptibility candidate gene. The protein product of PARK2, Parkin, is an E3 ubiquitin ligase that is involved in the development of various forms of Parkinsonism. The human macrophage is both a natural host cell of M. leprae as well as a primary mediator of natural immune defenses, in part by secreting important pro-inflammatory cytokines and chemokines. Here, we report that down-regulation of Parkin in THP-1 macrophages, human monocyte-derived macrophages and human Schwann cells resulted in a consistent and specific decrease in interleukin-6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1/CCL2) production in response to mycobacteria or LPS. Interestingly, production of IL-6 at 6 hours by THP-1 cells stimulated with live M. leprae and M. bovis BCG was dependent on pretreatment with 1,25-dihydroxyvitamin D3 (VD). Parkin knockdown in VD-treated cells blocked IL-6 induction by mycobacteria. However, I?B-? phosphorylation and levels of I?B-?, a nuclear protein required for IL-6 expression, were not affected by Parkin silencing. Phosphorylation of MAPK ERK1/2 and p38 was unaffected by Parkin silencing while JNK activation was promoted but did not explain the altered cytokine production. In a final set of experiments we found that genetic risk factors of leprosy located in the PARK2 promoter region were significantly correlated with M. leprae sonicate triggered CCL2 and IL6 transcript levels in whole blood assays. These results associated genetically controlled changes in the production of MCP-1/CCL2 and IL-6 with known leprosy susceptibility factors. PMID:23350010

de Lsleuc, Louis; Girard, Manon; Huong, Nguyen Thu; Ba, Nguyen Ngoc; Van Thuc, Nguyen; Truman, Richard; Spencer, John S.; Adams, Linda; Thai, Vu Hong; Alcais, Alexandre; Schurr, Erwin

2013-01-01

205

Free-Lagrange simulations of the expansion and jetting collapse of air bubbles in water  

NASA Astrophysics Data System (ADS)

A free-Lagrange numerical method is implemented to simulate the axisymmetric jetting collapse of air bubbles in water. This is performed for both lithotripter shock-induced collapses of initially stable bubbles, and for free-running cases where the bubble initially contains an overpressure. The code is validated using two test problems (shock-induced bubble collapse using a step shock, and shock10 MPa tensile waves, interacts with a bubble of initial radius 0.04 mm located in a free field (case 1) and near a rigid boundary (case 2). The interaction of the shock with the bubble causes it to involute and a liquid jet is formed that achieves a velocity exceeding 1.2 km s1 for case 2. The impact of the jet on the downstream wall of the bubble generates a blast wave with peak overpressure exceeding 1 GPa and 1.75 GPa for cases 1 and 2, respectively. The results show that the simulation technique retains sharply resolved gas/liquid interfaces regardless of the degree of geometric deformation, and reveal details of the dynamics of bubble collapse. The effects of compressibility are included for both liquid and gas phases, whereas stress distributions can be predicted within elastic-plastic solid surfaces (both planar and notched) in proximity to cavitation events. There is a movie with the online version of the paper.

Turangan, C. K.; Jamaluddin, A. R.; Ball, G. J.; Leighton, T. G.

206

An Euler-Lagrange method considering bubble radial dynamics for modeling sonochemical reactors.  

PubMed

Unsteady numerical computations are performed to investigate the flow field, wave propagation and the structure of bubbles in sonochemical reactors. The turbulent flow field is simulated using a two-equation Reynolds-Averaged Navier-Stokes (RANS) model. The distribution of the acoustic pressure is solved based on the Helmholtz equation using a finite volume method (FVM). The radial dynamics of a single bubble are considered by applying the Keller-Miksis equation to consider the compressibility of the liquid to the first order of acoustical Mach number. To investigate the structure of bubbles, a one-way coupling Euler-Lagrange approach is used to simulate the bulk medium and the bubbles as the dispersed phase. Drag, gravity, buoyancy, added mass, volume change and first Bjerknes forces are considered and their orders of magnitude are compared. To verify the implemented numerical algorithms, results for one- and two-dimensional simplified test cases are compared with analytical solutions. The results show good agreement with experimental results for the relationship between the acoustic pressure amplitude and the volume fraction of the bubbles. The two-dimensional axi-symmetric results are in good agreement with experimentally observed structure of bubbles close to sonotrode. PMID:23751457

Jamshidi, Rashid; Brenner, Gunther

2014-01-01

207

Lagrange Discrete Ordinates: a new angular discretization for the three dimensional linear Boltzmann equation  

E-print Network

The classical $S_n$ equations of Carlson and Lee have been a mainstay in multi-dimensional radiation transport calculations. In this paper, an alternative to the $S_n$ equations, the "Lagrange Discrete Ordinate" (LDO) equations are derived. These equations are based on an interpolatory framework for functions on the unit sphere in three dimensions. While the LDO equations retain the formal structure of the classical $S_n$ equations, they have a number of important differences. The LDO equations naturally allow the angular flux to be evaluated in directions other than those found in the quadrature set. To calculate the scattering source in the LDO equations, no spherical harmonic moments are needed--only values of the angular flux. Moreover, the LDO scattering source preserves the eigenstructure of the continuous scattering operator. The formal similarity of the LDO equations with the $S_n$ equations should allow easy modification of mature 3D $S_n$ codes such as PARTISN or PENTRAN to solve the LDO equations. ...

Ahrens, Cory D

2014-01-01

208

Implementation of the Euler-Lagrange and poisson equations to extract one connected region  

NASA Astrophysics Data System (ADS)

This paper presents a numerical method that evolves an active contour toward the boundary of one connected image region. The numerical method implements a model which uses the solution of the Euler-Lagrange Differential Equation in order to minimize a "snake" functional. This functional is constructed as an integral of the so called internal and external energies. The internal energy is related to the moving contour. The external energy represents the image. The minimum of the functional falls on the boundaries of objects placed in the image. A half step numerical scheme implements the concepts. The contributions of the new model come from the use of the solution of the Poisson equation and development of a new penalty function to halt the contour on the object's boundary. In order to make the contour move across homogeneous regions and enlarge the capture range, we solve the Poisson equation with Dirichlet boundary conditions and generate a gradient vector field of the image. The numerical method is implemented with MatLab and uses a stop condition based on the gradient. The advantages of the model are that it has a large capture range, is accurate in detecting the boundaries of image objects, and is capable of surpassing noise. A disadvantage is that the user has to select the right values of three parameters. Several experiments with synthetic, weapon, and medical images have been conducted to validate the model. Our work continues with the goal of cutting the curve in the event multiple objects have been enveloped.

Bowden, A.; Todorov, M. D.; Sirakov, N. M.

2014-11-01

209

Multinational underground nuclear parks  

SciTech Connect

Newcomer countries expected to develop new nuclear power programs by 2030 are being encouraged by the International Atomic Energy Agency to explore the use of shared facilities for spent fuel storage and geologic disposal. Multinational underground nuclear parks (M-UNPs) are an option for sharing such facilities. Newcomer countries with suitable bedrock conditions could volunteer to host M-UNPs. M-UNPs would include back-end fuel cycle facilities, in open or closed fuel cycle configurations, with sufficient capacity to enable M-UNP host countries to provide for-fee waste management services to partner countries, and to manage waste from the M-UNP power reactors. M-UNP potential advantages include: the option for decades of spent fuel storage; fuel-cycle policy flexibility; increased proliferation resistance; high margin of physical security against attack; and high margin of containment capability in the event of beyond-design-basis accidents, thereby reducing the risk of Fukushima-like radiological contamination of surface lands. A hypothetical M-UNP in crystalline rock with facilities for small modular reactors, spent fuel storage, reprocessing, and geologic disposal is described using a room-and-pillar reference-design cavern. Underground construction cost is judged tractable through use of modern excavation technology and careful site selection. (authors)

Myers, C.W. [Nuclear Engineering and Nonproliferation Division, Los Alamos National Laboratory, MS F650, Los Alamos, NM 87544 (United States); Giraud, K.M. [Wolf Creek Nuclear Operating Corporation, 1550 Oxen Lane NE, P.O. Box 411, Burlington, KS 66839-0411 (United States)

2013-07-01

210

Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives.  

PubMed

Inflammation of the female reproductive tract increases susceptibility to HIV-1 and other viral infections and, thus, it becomes a serious liability for vaginal products. Excessive release of proinflammatory cytokines may alter the mucosal balance between tissue destruction and repair and be linked to enhanced penetration and replication of viral pathogens upon chemical insult. The present study evaluates four surface-active microbicide candidates, nonoxynol-9 (N-9), benzalkonium chloride (BZK), sodium dodecyl sulfate, and sodium monolaurate for their activity against human sperm and HIV, and their capacity to induce an inflammatory response on human vaginal epithelial cells and by the rabbit vaginal mucosa. Spermicidal and virucidal evaluations ranked N-9 as the most potent compound but were unable to predict the impact of the compounds on vaginal cell viability. Interleukin (IL)-1 release in vitro reflected their cytotoxicity profiles more accurately. Furthermore, IL-1 concentrations in vaginal washings correlated with cumulative mucosal irritation scores after single and multiple applications (P < 0.01), showing BZK as the most damaging agent for the vaginal mucosa. BZK induced rapid cell death, IL-1 release, and IL-6 secretion. The other compounds required either more prolonged or repeated contact with the vaginal epithelium to induce a significant inflammatory reaction. Increased IL-8 levels after multiple applications in vivo identified compounds with the highest cumulative mucosal toxicity (P < 0.01). In conclusion, IL-1, IL-6, and IL-8 in the vaginal secretions are sensitive indicators of compound-induced mucosal toxicity. The described evaluation system is a valuable tool in identifying novel vaginal contraceptive microbicides, selecting out candidates that may enhance, rather than decrease, HIV transmission. PMID:15128598

Fichorova, R N; Bajpai, M; Chandra, N; Hsiu, J G; Spangler, M; Ratnam, V; Doncel, G F

2004-09-01

211

Autocrine IL-17AIL-17RC neutrophil activation in fungal infections is regulated by IL-6, IL-23, ROR?t and Dectin-2  

PubMed Central

Here we identified a population of bone marrow neutrophils that constitutively express ROR?t and which can produce and respond to IL-17A (IL-17). IL-6, IL-23 and ROR?t, but not T cells or NK cells, are required for IL-17 production in neutrophils. IL-6 and IL-23 induced IL-17RC and Dectin-2 expression in neutrophils, and expression of IL-17RC was augmented by Aspergillus and Dectin-2 activation. Autocrine IL-17AIL-17 receptor activity induced production of reactive oxygen species (ROS), and increased fungal killing in vitro and in a model of Aspergillus keratitis. Human neutrophils also expressed ROR?t, and induced IL-17A, IL-17RC and Dectin-2 expression following IL-6 and IL-23 stimulation. These findings identify a population of human and murine neutrophils that exhibit autocrine IL-17 activity, and which likely contribute to the etiology of microbial and inflammatory diseases. PMID:24362892

Taylor, Patricia R.; Roy, Sanhita; Leal, Sixto M.; Sun, Yan; Howell, Scott J.; Cobb, Brian A.; Li, Xiaoxia; Pearlman, Eric

2014-01-01

212

Characterization and Favorable in Vivo Properties of Heterodimeric Soluble IL-15IL-15R? Cytokine Compared to IL-15 Monomer*  

PubMed Central

Interleukin-15 (IL-15), a 114-amino acid cytokine related to IL-2, regulates immune homeostasis and the fate of many lymphocyte subsets. We reported that, in the blood of mice and humans, IL-15 is present as a heterodimer associated with soluble IL-15 receptor ? (sIL-15R?). Here, we show efficient production of this noncovalently linked but stable heterodimer in clonal human HEK293 cells and release of the processed IL-15sIL-15R? heterodimer in the medium. Purification of the IL-15 and sIL-15R? polypeptides allowed identification of the proteolytic cleavage site of IL-15R? and characterization of multiple glycosylation sites. Administration of the IL-15sIL-15R? heterodimer reconstituted from purified subunits resulted in sustained plasma IL-15 levels and in robust expansion of NK and T cells in mice, demonstrating pharmacokinetics and in vivo bioactivity superior to single chain IL-15. These identified properties of heterodimeric IL-15 provide a strong rationale for the evaluation of this molecule for clinical applications. PMID:23649624

Chertova, Elena; Bergamaschi, Cristina; Chertov, Oleg; Sowder, Raymond; Bear, Jenifer; Roser, James D.; Beach, Rachel K.; Lifson, Jeffrey D.; Felber, Barbara K.; Pavlakis, George N.

2013-01-01

213

IL17RC: a partner in IL17 signaling and beyond  

Microsoft Academic Search

The interleukin (IL)-17 cytokine family members IL-17A and IL-17F mediate inflammatory activities via the IL-17 receptor (IL-17R)\\u000a complex, comprised of the IL-17RA and IL-17RC subunits. Proper regulation of the IL-17 signaling axis results in effective\\u000a host defense against extracellular pathogens, while aberrant signaling can drive autoimmune pathology. Elucidating the molecular\\u000a mechanisms underlying IL-17 signal transduction can yield an enhanced understanding

Allen W. Ho; Sarah L. Gaffen

2010-01-01

214

Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition  

PubMed Central

Background Recently, different genetic variants located within the IL2/IL21 genetic region as well as within both IL2RA and IL2RB loci have been associated to multiple autoimmune disorders. We aimed to investigate for the first time the potential influence of the IL2/IL21, IL2RA and IL2RB most associated polymorphisms with autoimmunity on the endogenous non-anterior uveitis genetic predisposition. Methods A total of 196 patients with endogenous non-anterior uveitis and 760 healthy controls, all of them from Caucasian population, were included in the current study. The IL2/IL21 (rs2069762, rs6822844 and rs907715), IL2RA (2104286, rs11594656 and rs12722495) and IL2RB (rs743777) genetic variants were genotyped using TaqMan allelic discrimination assays. Results A statistically significant difference was found for the rs6822844 (IL2/IL21 region) minor allele frequency in the group of uveitis patients compared with controls (P-value=0.02, OR=0.64 CI 95%=0.43-0.94) although the significance was lost after multiple testing correction. Furthermore, no evidence of association with uveitis was detected for the analyzed genetic variants of the IL2RA or IL2RB loci. Conclusion Our results indicate that analyzed IL2/IL21, IL2RA and IL2RB polymorphisms do not seem to play a significant role on the non-anterior uveitis genetic predisposition although further studies are needed in order to clear up the influence of these loci on the non-anterior uveitis susceptibility. PMID:23676143

2013-01-01

215

Interleukin (IL)-1b Regulation of IL1b and IL1 Receptor Antagonist Expression in Cultured Human Endometrial Stromal Cells  

Microsoft Academic Search

The interleukin (IL)-1 system is a major regulator of local cellular interactions during embryonic implantation. Because IL-1b and IL receptor antagonist (IL-1ra) are both expressed in human endome- trium, we hypothesized that an appropriate ratio of IL-1b to IL-1ra might favor the process of embryo implantation. Therefore, we in- vestigated IL-1 regulation of the quantitative ratio of IL-1b\\/IL-1ra messenger RNA

HONG-YUAN HUANG; YAN WEN; JAN S. KRUESSEL; FRANCISCO RAGA; YUNG-KUEI SOONG; MARY LAKE POLAN

2010-01-01

216

Soluble murine IL-1 receptor type I induces release of constitutive IL-1 alpha.  

PubMed

IL-1 alpha and IL-1 beta are proinflammatory cytokines involved in the pathogenesis of many infectious and noninfectious inflammatory diseases. To reduce IL-1 toxicity, extracellular domains of the soluble (s) IL-1R are shed from cell membranes and prevent triggering of cell-bound receptors. We investigated to what extent murine sIL-1RI can neutralize the IL-1 produced by LPS-stimulated macrophages. When mouse peritoneal macrophages were incubated with LPS, addition of sIL-1RI significantly inhibited the bioactivity of IL-1. Stimulation of cells with sIL-1RI alone induced no bioactive IL-1. When immunoreactive cytokine concentrations were measured with specific radioimmunoassays, sIL-1RI alone appeared to induce a significant release of IL-1 alpha in a concentration-dependent manner. This effect was independent of new protein synthesis. The production of IL-1 beta or TNF-alpha was not influenced by sIL-1RI. There was no interference of sIL-1RI with the IL-1 alpha radioimmunoassay. In mice, an i.v. injection of sIL-RI alone induced a rapid release of IL-1 alpha, but not of TNF-alpha or IL-1 beta. Treatment of mice with sIL-1RI improved the survival during a lethal infection with Candida albicans. In conclusion, sIL-1RI induces a rapid release of IL-1 alpha from cells, as well as into the systemic circulation. Although this IL-1 alpha may be inactivated in circulation by the same sIL-1RI, this phenomenon probably has immunostimulatory effects at local levels where the sIL-1RI-induced IL-1 alpha acts in a paracrine or autocrine manner. PMID:10202032

Netea, M G; Kullberg, B J; Boerman, O C; Verschueren, I; Dinarello, C A; Van der Meer, J W

1999-04-15

217

Geology Fieldnotes: Badlands National Park, South Dakota  

NSDL National Science Digital Library

Badlands National Park, located in southwestern South Dakota, consists of 244,000 acres of sharply eroded buttes, pinnacles and spires blended with the largest, protected mixed grass prairie in the United States. Features include information on park geology, maps, photographs, visitor information, links to related publications, and lesson plans for teaching geology with National Park examples. The park geology section discusses the Park's geologic history during the Eocene and Oligocene epochs and the rich fossil deposits found there. Maps of the park and the surrounding area are included.

218

Comparison of in vivo effects of human recombinant IL 1 and human recombinant IL 6 in mice  

Microsoft Academic Search

IL 1 and IL 6 share a number of biological activities, including induction of fever, neutrophilia and acute phase response, and IL 1 induces IL 6 production by fibroblasts and macrophages. Therefore, it was proposed that IL 6 mediates many of the activities of IL 1. To test this hypothesis in vivo, we assessed induction of IL 6 following IL

R. Neta; S. N. Vogel; J. D. Sipe; G. G. Wong; R. P. Nordan

2009-01-01

219

IL TRAPIANTO ORTOTOPICO DEL FEGATO  

PubMed Central

Eormai noto che esiste la possibilit rivoluzionaria di utilizzare il fegato per il trattamento della stadio terminale delle epatopatie. Nel gennaio 1980 si celebra il decimo anna di sopravvivenza con fegato trapiantato (la pi lunga della letteratura) di un paziente da noi trattato. Si tratta di uno dei 12 malati sottoposti a trapianto e seguiti per pi di 5 anni. La nota positiva di questa tipo di trattamento rappresentata dalleccellente tenore di vita che i pazienti conducono e dalla riabilitazione sociale e professionale. La nota negativa data, invece, dal fatto che i buoni risultati non vengono raggiunti con regolarit e non possono essere previsti con esattezza. In questa breve rassegna considereremo la esperienza da noi fatta presso lUniversit di Denver nel Colorado, mettendo in risalto le cause dellelevata mortalit precoce e le prospettive future di questa mezzo terapeutico. PMID:21572898

STARZL, THOMAS E.

2010-01-01

220

Serum IL-17 and IL-6 increased accompany with TGF-? and IL-13 respectively in ulcerative colitis patients  

PubMed Central

Purposes: To explorer the serum level of pro- and anti-inflammatory cytokines in the patients of ulcerative colitis and irritable bowel disease. And analyze the correlation between the cytokines levels and diseases activity of ulcerative colitis patients. Methods: Serum cytokines of ulcerative colitis and irritable bowel syndrome with diarrhea patients including IL-6, IL-10, IL-13, IL-17, TNF-? and TGF-? were analyzed by enzyme linked immunosorbent assay, and ulcerative colitis activity were assessed by Mayo scoring system. The correlation of the serum level of cytokines and ulcerative colitis activity were analyzed by the SPSS 19.0 software. Results: Compared with healthy people, the serum level of IL-6, IL-10, IL-13, IL-17, TNF-? and TGF-? were elevated in ulcerative colitis patients. There is no direct correlation between each cytokines analyzed and the Mayo score. And the level of IL-6 is relevant to IL-13 (r=0.364, P=0.029), and the level of IL-17 is relevant to TGF-? (r=0.336, P=0.045). Conclusion: When the pro-inflammatory cytokines increase in the serum of ulcerative colitis, the anti-inflammatory cytokines were increased concomitantly, Some cytokines are positive correlated, such as IL-6 and IL-13, IL-17 and TGF-?, the mechanism of which is complex and needs further investigation. PMID:25664061

Feng, Jin-Shan; Yang, Zheng; Zhu, Yu-Zhen; Liu, Zhou; Guo, Can-Can; Zheng, Xue-Bao

2014-01-01

221

Cratylia mollis 1, 4 Lectin: A New Biotechnological Tool in IL-6, IL-17A, IL-22, and IL-23 Induction and Generation of Immunological Memory  

PubMed Central

Cratylia mollis lectin has already established cytokine induction in Th1 and Th2 pathways. Thereby, this study aimed to evaluate Cramoll 1, 4 in IL-6, IL-17A, IL-22, and IL-23 induction as well as analyze immunologic memory mechanism by reinducing lymphocyte stimulation. Initially we performed a screening in cultured splenocytes where Cramoll 1, 4 stimulated IL-6 production 5x more than ConA (P < 0.05). The same behavior was observed with IL-22 where the increase was greater than 4x. Nevertheless, IL-17A induction was similar for both lectins. In PBMCs, the same splenocytes course was observed for IL-6 and IL-17A. Concerning the stimulation of IL-22 and IL-23 Cramoll 1, 4 was more efficient than ConA in cytokines stimulation mainly in IL-23 (P < 0.01). Analyzing reinduced lymphocyte stimulation, IL-17A production was higher (P < 0.001) when the first stimulus was realized with Cramoll 1, 4 at 1??g/mL and the second at 5??g/mL. IL-22 shows significant differences (P < 0.01) at the same condition. Nevertheless, IL-23 revels the best response when the first stimuli was realized with Cramoll1, 4 at 100?ng/mL and the second with 5??g/mL. We conclude that the Cramoll 1, 4 is able to induce IL-6, IL-17A, IL-22, and IL-23 cytokines in vitro better than Concavalin A, besides immunologic memory generation, being a potential biotechnological tool in Th17 pathway studies. PMID:23586026

de Oliveira, Priscilla Stela Santana; Rgo, Moacyr Jesus Barreto de Melo; da Silva, Rafael Ramos; Cavalcanti, Mariana Brayner; Galdino, Suely Lins; Correia, Maria Tereza dos Santos; Coelho, Luana Cassandra Breitenbach Barroso; Pitta, Maira Galdino da Rocha

2013-01-01

222

Cratylia mollis 1, 4 lectin: a new biotechnological tool in IL-6, IL-17A, IL-22, and IL-23 induction and generation of immunological memory.  

PubMed

Cratylia mollis lectin has already established cytokine induction in Th1 and Th2 pathways. Thereby, this study aimed to evaluate Cramoll 1, 4 in IL-6, IL-17A, IL-22, and IL-23 induction as well as analyze immunologic memory mechanism by reinducing lymphocyte stimulation. Initially we performed a screening in cultured splenocytes where Cramoll 1, 4 stimulated IL-6 production 5x more than ConA (P < 0.05). The same behavior was observed with IL-22 where the increase was greater than 4x. Nevertheless, IL-17A induction was similar for both lectins. In PBMCs, the same splenocytes course was observed for IL-6 and IL-17A. Concerning the stimulation of IL-22 and IL-23 Cramoll 1, 4 was more efficient than ConA in cytokines stimulation mainly in IL-23 (P < 0.01). Analyzing reinduced lymphocyte stimulation, IL-17A production was higher (P < 0.001) when the first stimulus was realized with Cramoll 1, 4 at 1 ? g/mL and the second at 5 ? g/mL. IL-22 shows significant differences (P < 0.01) at the same condition. Nevertheless, IL-23 revels the best response when the first stimuli was realized with Cramoll1, 4 at 100 ng/mL and the second with 5 ? g/mL. We conclude that the Cramoll 1, 4 is able to induce IL-6, IL-17A, IL-22, and IL-23 cytokines in vitro better than Concavalin A, besides immunologic memory generation, being a potential biotechnological tool in Th17 pathway studies. PMID:23586026

de Oliveira, Priscilla Stela Santana; Rgo, Moacyr Jesus Barreto de Melo; da Silva, Rafael Ramos; Cavalcanti, Mariana Brayner; Galdino, Suely Lins; Correia, Maria Tereza dos Santos; Coelho, Luana Cassandra Breitenbach Barroso; Pitta, Maira Galdino da Rocha

2013-01-01

223

Bibliography of Doctor Chul Park  

NASA Technical Reports Server (NTRS)

This document contains a comprehensive bibliography of the published works, and a short biography, of Dr. Chul Park. The contents of this bibliography were compiled primarily from the NASA RECON data base. The RECON citations have been modified to appear in a uniform format with all other listed citations . These other citations were located by computer searches in the INSPEC, NTIS, COMPENDEX, and Chemical Abstracts data bases, as well as through the cooperation of Dr. Chul Park, and his associates in the Reacting Flow Environments Branch at NASA Ames Research Center. All citations are presented in an approximate reverse chronological order from the present date. This work was created to honor the occasion of Dr. Chul Park's retirement on December 14, 1994, after 27 years of distinguished government service at the NASA Ames Research Center.

Gochberg, Lawrence A.; Venkatapathy, Ethiraj; Park, Chul

1995-01-01

224

Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction.  

PubMed

IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Ralpha1 (IL-13 receptor alpha-chain 1) and IL-4Ralpha. The second IL-13R (IL-13 receptor) has been identified, namely IL-13Ralpha2. This has been thought to be a decoy receptor due to its short cytoplasmic tail and its high binding affinity for IL-13 but not IL-4. IL-13Ralpha2 exists on the cell membrane, intracellularly and in a soluble form. Recent reports revealed that membrane IL-13Ralpha2 may have some signalling capabilities, and a soluble form of IL-13Ralpha2 can be generated in the presence of environmental allergens such as DerP. Interestingly, IL-13Ralpha2 has also been shown to regulate both IL-13 and IL-4 response in primary airway cells, despite the fact that IL-13Ralpha2 does not bind IL-4. The regulator mechanism is still unclear but the physical association of IL-13Ralpha2 with IL-4Ralpha appears to be a key regulatory step. These results suggest that the cytoplasmic tail of IL-13Ralpha2 may interfere with the association or activation of signalling molecules, such as JAK1 (Janus kinase 1), on IL-4Ralpha and thus prevents downstream signal cascade. The receptor has more complicated functions than a simple decoy receptor. In this review, we discuss newly revealed functions of IL-13Ralpha2. PMID:19614610

Andrews, Allison-Lynn; Nordgren, Ida Karin; Kirby, Isabelle; Holloway, John W; Holgate, Stephen T; Davies, Donna E; Tavassoli, Ali

2009-08-01

225

Cytokine interactions in human immunodeficiency virus-infected individuals: roles of interleukin (IL)-2, IL-12, and IL-15  

PubMed Central

Cytokines have been shown to be powerful regulators of the immune response. In this study, we analyze the effect that the newly recognized cytokine interleukin (IL)-15 has on proliferation and cytokine induction using peripheral blood mononuclear cells (PBMCs) and purified CD4+ T cells from patients infected with human immunodeficiency virus (HIV) who are at various stages in their disease. We observed that IL-15 enhances the proliferative response in a dose-dependent manner from PBMCs of HIV-infected individuals when stimulated by polyclonal mitogen, tetanus toxoid, or HIV-specific antigen. The effects of exogenous IL-15 are substantially diminished by adding a neutralizing antibody to the beta chain of the IL-2 receptor. Moreover, the ability of IL-15 to increase proliferation is enhanced by the presence of endogenous IL-2 produced in the cultures. The effect that exogenous IL-15 had on IL-2, IL-4, and interferon (IFN)-gamma induction from PBMC's or CD4+ T cells in response to mitogen or tetanus toxoid was also examined. This was compared to the effect that exogenous IL-2 and IL-12 had under the same conditions. Addition of IL- 2 or IL-15 to short-term in vitro cultures of either PBMCs or CD4+ T cells had little effect on IL-2, IL-4, or IFN-gamma production. By contrast, IL-12 caused substantial enhancement of both IL-2 and IFN- gamma production from these cultures. The role that endogenous cytokines have on IFN-gamma induction was also studied. Addition of a neutralizing antibody to the alpha chain of the IL-2 receptor or IL-12 to antigen stimulated cultures caused a striking decrease in IFN-gamma production. Neutralization of endogenous IL-15 also resulted in diminished IFN-gamma production from cultures stimulated with mitogen. IL-4 and IFN-gamma protein production by PBMCs and CD4+ T cells stimulated with mitogen was assessed to see if we could detect a specific bias of cytokine production. Small amounts of IL-4 were detected from CD4+ T cells but not PBMCs from most individuals tested. IFN-gamma and IL-2, however, were also produced from these same cultures. These results further elucidate the mechanism of cytokine regulation in HIV-infected individuals, and they provide evidence that IL-15 may be a useful immune modulator. PMID:7561680

1995-01-01

226

Jagged-1 signaling suppresses the IL-6 and TGF-? treatment-induced Th17 cell differentiation via the reduction of ROR?t/IL-17A/IL-17F/IL-23a/IL-12rb1  

PubMed Central

Jagged-1 signaling has recently been reported to be involved in the Th17 cell differentiation. However, little is known about its mechanisms. Soluble Jagged-1 was used to activate the Jagged-1Notch signaling to interfere with the IL-6 and TGF-?-induced Th17 cell skewing. Genes relevant to the autoimmunity or inflammation were screened for the first time in this system by qPCR array for the differential expressions. The 18 genes out of 84, including Clec7a, Il12b, Il12rb1, Il12rb2, Csf3, Il15, Il17a, Il17f, Il17rc, Il17rd, Il17re, Il23a, Myd88, Socs1, Stat4, Stat5a, Sykb and Tbx21, were downregulated, but only Cxcl2, Cxcl12 and Mmp3 were upregulated. The expressions of the genes, Ror?t, Il17a, Il17f, Il12rb1 and Il23a, induced by simultaneous IL-6 and TGF-? treatment were significantly suppressed by Jagged-1, followed by the reduction of ROR?t, IL-17A, and IL-17F. Consistent with the attenuation of ROR?t, and the reduced production and secretion of IL-17A and IL-17F in the cell supernatant and the in situ stained cells, the number of CD4+IL-17+ cells was also diminished. It is concluded that the Jagged-1Notch signaling can suppress the IL-6 and TGF-? treatment-induced Th17 cell skewing through the attenuation of ROR?t and, hence by, the down-regulation of IL-17A, IL-17F, IL-23a, and IL-12rb1. PMID:25648768

Wang, Yuan; Xing, Feiyue; Ye, Siqi; Xiao, Jia; Di, Jingfang; Zeng, Shan; Liu, Jing

2015-01-01

227

Quantitative analysis of IL-2 and IL-15 signal transduction in T lymphocytes  

E-print Network

IL-2 and IL-15 are common y-chain family cytokines critically involved in regulation of T cell differentiation and homeostasis. Both cytokines signal through a heterotrimeric surface receptor complex (IL-2/15R) composed ...

Arneja, Abhinav

2013-01-01

228

IL-21 induces IL-22 production in CD4+ T-cells  

PubMed Central

IL-22 produced by innate lymphoid cells (ILCs) and CD4+ T cells plays an important role in host defense and mucosal homeostasis, thus it is important to investigate the mechanisms that regulate IL-22 production. We investigated the regulation IL-22 production by CD4+ T cells. Here we show that IL-21 triggers IL-22, but not IL-17 production by CD4+ T cells. STAT3, activated by IL-21, controls the epigenetic status of the il22 promoter and its interaction with the aryl hydrocarbon receptor (AhR). Moreover, IL-21 and AhR signaling in T cells control IL-22 production and the development of dextran sodium sulfate-induced colitis in ILC-deficient mice. Thus, we have identified IL-21 as an inducer of IL-22 production in CD4+ T cells in vitro and in vivo. PMID:24796415

Yeste, Ada; Mascanfroni, Ivan D.; Nadeau, Meghan; Burns, Evan J.; Tukpah, Ann-Marcia; Santiago, Andrezza; Wu, Chuan; Patel, Bonny; Kumar, Deepak; Quintana, Francisco J.

2014-01-01

229

( -:) http://davidson.weizmann.ac.il miri.kesner@weizmann.ac.il  

E-print Network

, " ." , . , . . , , . . ( -:) http://davidson.weizmann.ac.il , " " miri.kesner@weizmann.ac.il #12:30-13:00,08-9378360 #12;4 : - : http://davidson" :il/alefbethttp://davidson.weizmann.ac. #12;7 ' - ' 1. : , -. 2

Maoz, Shahar

230

Everglades National Park Including Biscayne National Park. Activity Book.  

ERIC Educational Resources Information Center

Intended to help elementary school children learn about the resources of the Everglades and Biscayne National Parks, this activity book includes information, puzzles, games, and quizzes. The booklet deals with concepts related to: (1) the seasons; (2) fire ecology; (3) water; (4) fish; (5) mammals; (6) mosquitos; (7) birds; (8) venomous snakes;

Ruehrwein, Dick

231

City of New York Parks & Recreation  

NSDL National Science Digital Library

New York City's Department of Parks & Recreation oversees 29,000 acres of land, and more than 1,700 parks, playgrounds, and recreation facilities located throughout the five boroughs. Their website provides a great starting point for a virtual visit undaunted by weather. Take a virtual tour along the Bronx River, watch video clips from "It's My Park" (also aired every weekday at 11:00 a.m. on NYC life (channel 25)), and browse the photo gallery, which includes selections from the Parks Photo Archive, dating back to 1856, and the Parks' Flickr Group, with visitor-contributed photos. There are also seasonal features: for February, Black History Month, there's an events listing, an inventory of permanent sculptures honoring African-Americans in the Parks, African American Namesake Parks, and a photo gallery entitled The African American Experience. And of course, there's a Groundhog Day page, presenting the history of weather prediction by the rodent in the NYC Parks.

232

Elevated Plasma IL-37, IL-18, and IL-18BP Concentrations in Patients with Acute Coronary Syndrome  

PubMed Central

Objective. More recently, evidence showed that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in the foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting that IL-37 is involved in atherosclerosis-related diseases. However, the plasma levels of IL-37 in patients with acute coronary syndrome (ACS, including unstable angina pectoris and acute myocardial infarction) have yet to be investigated. Methods. Plasma IL-37, IL-18, and IL-18BP levels were measured in 50 patients with stable angina pectoris (SAP), 75 patients with unstable angina pectoris (UAP), 67 patients with acute myocardial infarction (AMI), and 65 control patients. Results. The plasma IL-37, IL-18, and IL-18BP levels were significantly increased in ACS patients compared to SAP and control patients. A correlation analysis showed that the plasma biomarker levels were positively correlated with each other and with the levels of C-reactive protein (CRP), N-terminal probrain natriuretic peptide (NT-proBNP), and left ventricular end-diastolic dimension (LVEDD) but negatively correlated with left ventricular ejection fraction (LVEF). Furthermore, the plasma IL-37, IL-18, and IL-18BP had no correlation with the severity of the coronary artery stenosis. Conclusions. The results indicate that the plasma IL-37 levels are associated with the onset of ACS. PMID:24733959

Ji, Qingwei; Zeng, Qiutang; Huang, Ying; Shi, Ying; Lin, Yingzhong; Lu, Zhengde; Meng, Kai; Wu, Bangwei; Yu, Kunwu; Chai, Meng; Liu, Yuyang

2014-01-01

233

Unique Versus Redundant Functions of IL-1? and IL-1? in the Tumor Microenvironment  

PubMed Central

Interleukin-1 (IL-1) is a major alarm upstream pro-inflammatory cytokine that also affects immunity and hematopoiesis by inducing cytokine cascades. In the tumor arena, IL-1 is produced by malignant or microenvironmental cells. As a pleiotropic cytokine, IL-1 is involved in tumorigenesis and tumor invasiveness but also in the control of anti-tumor immunity. IL-1? and IL-1? are the major agonists of IL-1, while IL-1Ra is a physiological inhibitor of pre-formed IL-1. In their secreted form, IL-1? and IL-1? bind to the same receptors and induce the same biological functions, but IL-1? and IL-1? differ in their compartmentalization within the producing cell or the microenvironment. IL-1? is only active in its processed, secreted form, and mediates inflammation, which promotes carcinogenesis, tumor invasiveness, and immunosuppression, whereas IL-1? is mainly cell-associated and in the tumor context, when expressed on the cell membrane, it stimulates anti-tumor cell immunity manifested by tumor regression. In the tumor milieu, extracellular levels of IL-1? are usually low and do not stimulate broad inflammation that promotes progression. Immunosuppression induced by IL-1? in the tumor microenvironment, mainly through MDSC induction, usually inhibits or masks anti-tumor cell immunity induced by cell-associated IL-1?. However, in different tumor systems, redundant or unique patterns of IL-1? and IL-1? expression and function have been observed. Recent breakthroughs in inflammasome biology and IL-1? processing/secretion have spurred the development of novel anti-IL-1 agents, which are being used in clinical trials in patients with diverse inflammatory diseases. Better understanding of the integrative role of IL-1? and IL-1? in distinct malignancies will facilitate the application of novel IL-1 modulation approaches at the bedside, in cancer patients with minimal residual disease (MRD), as an adjunct to conventional approaches to reduce the tumor burden. PMID:23847618

Voronov, Elena; Dotan, Shahar; Krelin, Yakov; Song, Xiaoping; Elkabets, Moshe; Carmi, Yaron; Rider, Peleg; Idan Cohen; Romzova, Marianna; Kaplanov, Irena; Apte, Ron N.

2013-01-01

234

IL18 gene polymorphisms affect IL18 production capability by monocytes  

Microsoft Academic Search

We previously demonstrated a significant association between IL-18 gene polymorphism 105A\\/C and asthma. In this study, we investigated the relationship of IL-18 gene polymorphism to IL-18 production capability by monocytes. The frequency of gene polymorphisms including IL-18-105A\\/C and IL-18-?137G\\/C was determined by PCR analyses. The IL-18 production by monocytes stimulated without or with LPS or A23187+PMA for 1day was measured

Junsuke Arimitsu; Toru Hirano; Shinji Higa; Mari Kawai; Tetsuji Naka; Atsushi Ogata; Yoshihito Shima; Minoru Fujimoto; Tomoki Yamadori; Keisuke Hagiwara; Tomoharu Ohgawara; Yusuke Kuwabara; Ichiro Kawase; Toshio Tanaka

2006-01-01

235

VENDERE IL LEGNO CON RESPONSABILITA'  

E-print Network

mass media, le istituzioni pubbliche e private, ...) Definizione di green marketing = un'evoluzione del: "pettenella" www.tesaf.unipd.it/pettenella/index.html 1. Introduzione Dal Total marketing al Social marketing iniziative del settore pubblico #12;2 Evoluzione del marketing Fino agli anni '30 il m. si concentra sui

Pettenella, Davide

236

East Tennessee Technology Park 3-1 3. East Tennessee Technology Park  

E-print Network

East Tennessee Technology Park 3-1 3. East Tennessee Technology Park ETTP was originally built to the East Tennessee Technology Park. Environmental management and remediation operations consist, the K-25 Site was renamed the "East Tennessee Technology Park" to reflect its new mission. Figure 3

Pennycook, Steve

237

East Tennessee Technology Park 3-1 3. East Tennessee Technology Park  

E-print Network

East Tennessee Technology Park 3-1 3. East Tennessee Technology Park The East Tennessee Technology was changed to the East Tennessee Technology Park. Environmental management and remediation operations consist Tennessee Technology Park (ETTP), originally known as the K-25 site, began in 1943 as part of the World War

Pennycook, Steve

238

East Tennessee Technology Park 3-1 3. East Tennessee Technology Park  

E-print Network

1 East Tennessee Technology Park 3-1 3. East Tennessee Technology Park ETTP was originally built to the "East Tennessee Technology Park." Environmental management and remediation operations consist the start of D&D activities. In 1997, the K-25 Site was renamed the "East Tennessee Technology Park

Pennycook, Steve

239

Welcome to Diamond Light Source Parking Visitors can park outside Diamond  

E-print Network

Welcome to Diamond Light Source Parking ­ Visitors can park outside Diamond House, or if that is full, in the Visitor car park. Users should park around the ring. On Arrival ­ Diamond does not have 8500). Then take a seat 2 and wait for your Diamond contact to collect you. Users ­ Fast track users

Crowther, Paul

240

Acadia National Park - Nature and Science  

NSDL National Science Digital Library

This National Park Service (NPS) website highlights the natural resources of Acadia National Park. Resources discussed include animals (amphibians, birds and fish), plants (ferns, freshwater plants, grasses, mosses, liverworts and wildflowers), environmental factors (fire regime, pests, nonnative species, weather, water quality and air quality), and natural features of the park (beaches, coastline, forests, geologic formations, intertidal and subtidal zones, mountains, and wetlands). There are related documents about the park's air and water quality available to download.

241

Geology Fieldnotes: Grand Canyon National Park, Arizona  

NSDL National Science Digital Library

Visitors can access park geology information, photographs, related links, visitor information, multimedia resources, and resources for teaching geology with National Park examples. The park geology section discusses the Grand Canyon's geologic history, structural geology, and features a question-and-answer section about the canyon. The history of the canyon as a park and environmental issues surrounding it are also discussed. A geologic cross section of the canyon showing the various rock layers is included.

242

Recombinant p35 from Bacteria Can Form Interleukin (IL-)12, but Not IL-35  

PubMed Central

The Interleukin (IL)-12 family contains several heterodimeric composite cytokines which share subunits among each other. IL-12 consists of the subunits p40 (shared with IL-23) and p35. p35 is shared with the composite cytokine IL-35 which comprises of the p35/EBI3 heterodimer (EBI3 shared with IL-27). IL-35 signals via homo- or heterodimers of IL-12R?2, gp130 and WSX-1, which are shared with IL-12 and IL-27 receptor complexes, respectively. p35 was efficiently secreted in complex with p40 as IL-12 but not with EBI3 as IL-35 in several transfected cell lines tested which complicates the analysis of IL-35 signal transduction. p35 and p40 but not p35 and EBI3 form an inter-chain disulfide bridge. Mutation of the responsible cysteine residue (p40C197A) reduced IL-12 formation and activity only slightly. Importantly, the p40C197A mutation prevented the formation of antagonistic p40 homodimers which enabled the in vitro reconstitution of biologically active IL-12 with p35 produced in bacteria (p35bac). Reconstitution of IL-35 with p35bac and EBI3 did, however, fail to induce signal transduction in Ba/F3 cells expressing IL-12R?2 and gp130. In summary, we describe the in vitro reconstitution of IL-12, but fail to produce recombinant IL-35 by this novel approach. PMID:25259790

Aparicio-Siegmund, Samadhi; Moll, Jens M.; Lokau, Juliane; Grusdat, Melanie; Schrder, Jutta; Plhn, Svenja; Rose-John, Stefan; Grtzinger, Joachim; Lang, Philipp A.; Scheller, Jrgen; Garbers, Christoph

2014-01-01

243

Untangling the Complex Web of IL-4- and IL-13-Mediated Signaling Pathways  

NSDL National Science Digital Library

Unraveling the exact signaling events mediating the distinct functions of the T cellderived cytokines interleukin-4 (IL-4) and IL-13 has been challenging because they are structurally similar and share a functional signaling receptor chain. A study now proposes a potential molecular mechanism to explain the functional differences between IL-4 and IL-13 that involves the ability of IL-4, but not IL-13, to effectively activate the insulin receptor substrate2 (IRS-2) signaling cascade through binding to its receptor. A better understanding of the interactions of IL-4 and IL-13 with their cognate receptors may facilitate the development of therapies without unintended side effects.

Marsha Wills-Karp (Cincinnati Children's Hospital Medical Center; Division of Immunobiology REV)

2008-12-23

244

Geology Fieldnotes: Acadia National Park, Maine  

NSDL National Science Digital Library

This National Park Service website highlights the geology of Acadia National Park. The story begins 500 million years ago, and goes through rock cycles, formations (Ellsworth, Bar Harbor, and Cranberry formations), intrusions, the Ice Age, glacial features, and development of shore patterns. There are area and park maps, photos, and links to additional information.

245

Geology Fieldnotes: Glacier National Park, Montana  

NSDL National Science Digital Library

Glaciers have played an important role in shaping this park, which is part of the Rocky Mountain chain and shares a border with Canada's Waterton Lakes National Park. Information on this site includes park geology, visitor information, photographs, and links to other resources.

246

Moon Park: A research and educational facility  

NASA Technical Reports Server (NTRS)

Moon Park has been proposed as an International Space Year (ISY) event for international cooperative efforts. Moon Park will serve as a terrestrial demonstration of a prototype lunar base and provide research and educational opportunities. The kind of data that can be obtained in the Moon Park facilities is examined taking the minimum number of lunar base residents as an example.

Kuriki, Kyoichi; Saito, Takao; Ogawa, Yukimasa

1992-01-01

247

Yellowstone National Park Online Slide File  

NSDL National Science Digital Library

This Yellowstone National Park website contains thousands of photographs of the Park. Images are organized by category including fire, thermal features, mammals, park structures, petrified trees, water, weather, scenics, and more. The photographs may be freely downloaded and more are being added through time.

Yellowstone National Park

248

Alluvial Fan, Rocky Mountain National Park  

USGS Multimedia Gallery

The Alluvial Fan is a fan-shaped area of disturbance in Rocky Mountain National Park. It was created on July 15, 1982, when the earthen Lawn Lake Dam above the area gave way, flooding the Park and nearby town of Estes Park with more than 200 million gallons of water. Enormous boulders were displaced...

249

"The Rosa Parks Story": Guide for Educators.  

ERIC Educational Resources Information Center

On December 1, 1955, Rosa Parks, a black seamstress, refused to give up her seat to a white man on a public bus in Montgomery, Alabama, and she was arrested. On that day, Rosa Parks became the mother of the modern civil rights movement. This study guide may be used as a companion to "The Rosa Parks Story" video which aired on CBS television

Onish, Liane B.

250

78 FR 24323 - National Park Week, 2013  

Federal Register 2010, 2011, 2012, 2013

...Proclamation 8961 of April 19, 2013 National Park Week, 2013 By the President of the United States...to be passed on. During National Park Week, we celebrate the wonders entrusted to...summon us to experience it firsthand. This week, the National Park Service will make...

2013-04-24

251

Where Innovation Is Tradition Parking & Transportation  

E-print Network

Cantor · Parking Services Coordinator: Ann Moran · Transportation Coordinator: Marina Budimir · Parking & Transportation Budget · Self-funded auxiliary · Receives no tuition dollars nor general funds · Must pay for all expenses with parking revenue and some student fee(about $88/student) · Overall budget nearly $15

252

Oak Park Village, Illinois Community Profile  

E-print Network

Oak Park Village, Illinois Community Profile William Gillespie UPP 502 · Drucker · November 28 for the village of Oak Park, Illinois. It is intended to highlight important information about the community a variety of sources, including the U.S. Census Bureau, the Village of Oak Park, and the Chicago

Illinois at Chicago, University of

253

Derivation of Explicit Difference Schemes for Ordinary Differential Equations with the Aid of Lagrange-Burmann Expansions  

NASA Astrophysics Data System (ADS)

We propose to derive the explicit multistage methods of the Runge-Kutta type for ordinary differential equations (ODEs) with the aid of the expansion of grid functions into the Lagrange-Burmann series. New explicit first- and second-order methods are derived, which are applied to the numerical integration of the Cauchy problem for a moderately stiff ODE system. It turns out that the L 2 norm of the error of the solution obtained by the new numerical second-order method is 50 times smaller than in the case of the classical second-order Runge-Kutta method.

Vorozhtsov, Evgenii V.

254

Tour of Park Geology: Hot Springs/Geothermal  

NSDL National Science Digital Library

This National Park Service (NPS) site provides links to National Parks with hot springs or geothermal activity. Where appropriate, links are provided to geology, visitor information, photographs, park maps, multimedia resources, geologic research, and additional links. Parks at this site include Hot Springs National Park, Lassen Volcano National Park, and more.

255

Travel Operations College Park 300  

E-print Network

business meals (excluding alcohol beverages and tobacco) charged to a Procurement Card Directive 11 in the estimated amount for only mileage, parking, toll, and business meals charged to a Procurement Card. #12 business meals (excluding alcohol beverages and tobacco) charged to a Procurement Card Directive 11

de Lijser, Peter

256

Symmetry in the Car Park  

ERIC Educational Resources Information Center

In this article, the author presents a lesson on rotational symmetry which she developed for her students. The aim of the lesson was "to identify objects with rotational symmetry in the staff car park" and the success criteria were "pictures or sketches of at least six objects with different orders of rotation". After finding examples of

Hancock, Karen

2007-01-01

257

National Park Glaciers Knowledge Center  

NSDL National Science Digital Library

This interactive resource explains what glaciers are, where they are found, how they form, and how they move. The types and parts of glaciers are discussed, as well as ice ages, the different types of landforms that may result from glaciation, and how scientists monitor glaciers. Examples from our national parks are also highlighted as case studies to illustrate how glaciers have created landscapes.

2005-08-01

258

Vehicle Operation and Parking Policy  

E-print Network

Vehicle Operation and Parking Policy Responsible Administrative Unit: Finance & Administration in this policy. 2.0 POLICY STATEMENT This policy is intended to promote safe driving by operators of all vehicles are in effect at all times and apply to all persons and vehicles physically present on the CSM campus

259

Vehicle Operation and Parking Policy  

E-print Network

Vehicle Operation and Parking Policy Responsible Administrative Unit: Finance & Administration STATEMENT This policy is intended to promote safe driving by operators of all vehicles utilizing streets and apply to all persons and vehicles physically present on the CSM campus. For the purpose of this policy

260

Travel Operations College Park 300  

E-print Network

approval. Office of University Risk Management will notify department. Travel Prepayment for RegistrationTravel Operations College Park 300 Email: travel@fullerton.edu Business Travel and Prepayment Request Employee Travel Policy and Procedures Page 1 of 12 Revised 9/1/2013 If the traveler is currently

de Lijser, Peter

261

Travel Operations College Park 300  

E-print Network

(including U.S. Possessions). Contact Risk Management at extension 7346 to obtain foreign travel liabilityTravel Operations College Park 300 Em ail: travel@fu llerton .edu EMPLOYEE TRAVEL (travel on or after 4/1/11) Policy and Procedures for Business Travel and Prepayment Request Page 1 of 12 Revised 4

de Lijser, Peter

262

Travel Operations College Park 300  

E-print Network

approval. Office of University Risk Management will notify department. Travel Prepayment for RegistrationTravel Operations College Park 300 Email: travel@fullerton.edu Business Travel and Prepayment Request Employee Travel Policy and Procedures Page 1 of 12 Revised 1/1/2014 If the traveler is currently

de Lijser, Peter

263

Travel Operations College Park 300  

E-print Network

is required for most international travel (including U.S. Possessions). Contact Risk Management at extensionTravel Operations College Park 300 Email: travel@fullerton.edu EMPLOYEE TRAVEL (travel on or after 4/1/11) Policy and Procedures for Travel Authorization and Prepayment Request Page 1 of 11 Revised 8

de Lijser, Peter

264

Travel Operations College Park 300  

E-print Network

is required for most international travel (including U.S. Possessions). Contact Risk Management at extensionTravel Operations College Park 300 Email: travel@fullerton.edu EMPLOYEE TRAVEL (travel on or after 4/1/11) Checklist for the Travel Authorization Page 1 of 11 Revised 4/19/2011 If the traveler

de Lijser, Peter

265

Travel Operations College Park 300  

E-print Network

(including U.S. Possessions). Contact Risk Management at extension 7346 to obtain foreign travel liabilityTravel Operations College Park 300 Email: travel@fullerton.edu EMPLOYEE TRAVEL (travel on or after 4/1/11) Policy and Procedures for Business Travel and Prepayment Request Page 1 of 12 Revised 5

de Lijser, Peter

266

Travel Operations College Park 300  

E-print Network

travel (including U.S. Possessions). Contact Risk Management at extension 7346 to obtain foreign travelTravel Operations College Park 300 Email: travel@fullerton.edu EMPLOYEE TRAVEL (travel on or after 4/1/11) Policy and Procedures for Business Travel and Prepayment Request Page 1 of 13 Revised 11

de Lijser, Peter

267

Travel Operations College Park 300  

E-print Network

the required foreign travel liability insurance from the Office of University Risk Management? · Select one high hazard; travel will require Chancellor's Office approval. Office of University Risk ManagementTravel Operations College Park 300 Email: travel@fullerton.edu EMPLOYEE TRAVEL (travel on or after

de Lijser, Peter

268

Travel Operations College Park 300  

E-print Network

approval. Office of University Risk Management will notify department. Travel Prepayment for RegistrationTravel Operations College Park 300 Email: travel@fullerton.edu Business Travel and Prepayment Request Employee Travel Policy and Procedures Page 1 of 12 Revised 8/21/2014 If the traveler is currently

de Lijser, Peter

269

Travel Operations College Park 300  

E-print Network

approval. Office of University Risk Management will notify department. Travel Prepayment for RegistrationTravel Operations College Park 300 Email: travel@fullerton.edu Business Travel and Prepayment Request Employee Travel Policy and Procedures Page 1 of 12 Revised 1/22/2013 If the traveler is currently

de Lijser, Peter

270

Travel Operations College Park 300  

E-print Network

approval. Office of University Risk Management will notify department. Travel Prepayment for RegistrationTravel Operations College Park 300 Email: travel@fullerton.edu Business Travel and Prepayment Request Employee Travel Policy and Procedures Page 1 of 12 Revised 6/14/2013 If the traveler is currently

de Lijser, Peter

271

Rosa Parks: The Movement Organizes.  

ERIC Educational Resources Information Center

This biography for younger readers describes the life of Rosa Parks, the Alabama black woman whose refusal to give up her seat on a segregated bus helped establish the civil rights movement. The book is introduced by an overview of the movement by Andrew Young and a timeline indicating major historical events from 1954 through 1968. Highlights in

Friese, Kai

272

Romanticism and American National Parks  

Microsoft Academic Search

The national park idea was conceived at a time when nature romanticism dominated Americans' sense of landscape aesthetics. Among the basic tenets of romantic philosophy discussed are the specific definitions of the picturesque and the sublime, importance of historical and romantic associations, role of emotional response to natural scenery, perception of God in nature, restorative powers of nature, and perceptions

Stanford E. Demars

1990-01-01

273

Egmont National Park, New Zealand  

NASA Technical Reports Server (NTRS)

The lush forests of Egmont National Park, on New Zealand's North Island, contrast with the pasturelands outside the circular park boundaries. The unique shape of the park results from its first protection in 1881, which specified that a forest reserve would extend in a 9.6 km radius from the summit of Mt. Taranaki (named Mt. Egmont by Captain Cook). The park covers about 33,500 hectares and Mt. Egmont stands at 2518 m. The volcano began forming 70,000 years ago, and last erupted in 1755. A series of montane habitats occur in procession up the flanks of the volcano-from rainforest, to shrubs, to alpine, and finally snow cover. Image STS110-726-6, was taken by Space Shuttle crewmembers on 9 April 2002 using a Hasselblad film camera. Image provided by the Earth Sciences and Image Analysis Laboratory at Johnson Space Center. Additional images taken by astronauts and cosmonauts can be viewed at the NASA-JSC Gateway to Astronaut Photography of Earth.

2002-01-01

274

Blue Spring State Park Immunization  

E-print Network

Park is 2,600 acres about 45 minutes from Gainesville. In the winter, you can see manatees but unfortunately, you can't swim with them. This weekend, since the manatees aren't there yet we will go swimming

Pilyugin, Sergei S.

275

Forest Park Academic Advising Handbook.  

ERIC Educational Resources Information Center

Designed to facilitate the academic counseling and advising process, this handbook provides comprehensive information pertaining to all transfer and career programs offered at the Forest Park Campus of St. Louis Community College. Section I provides general information on placement, tests, selective or restrictive programs, student status, summer

Kapraun, E. Daniel

276

Differential regulation by IL-4 and IL-10 of radiation-induced IL-6 and IL-8 production and ICAM-1 expression by human endothelial cells.  

PubMed

Radiation exposure results in an inflammatory reaction with acute as well as subacute consequences. Leukocyte infiltration is one of the predominant early histological changes and involves both cytokines and adhesion molecules. Endothelial cells play a key role in this reaction. We have previously shown the increased production of interleukin 6 (IL-6) and IL-8 and the upregulation in intercellular adhesion molecule 1 (ICAM-1) expression by HUVEC following gamma ray exposure. In the present study, we used the cytokines IL-4 and IL-10 to regulate these radiation-induced manifestations. Human umbilical vascular endothelial cells (HUVEC) were treated with IL-4 and IL-10 (50 pg/ml) either before or after 10- Gy irradiation. Three and seven days after irradiation, IL-6 and IL-8 production by HUVEC (either treated or non-treated) was assessed by enzyme-linked immunosorbent assay (ELISA). Our results show that IL-4, when added after irradiation, reversed the radiation-induced increase in IL-8 production, although slightly increased IL-6 production. IL-10 decreased both IL-8 and IL-6 production when added after irradiation. ICAM-1 expression was evaluated 3 days after irradiation by flow cytometry. The radiation-induced upregulation in ICAM-1 expression remained unaffected by the use of IL-4. Altogether, our results show that radiation-induced endothelial cell activation may be ameliorated by IL-4 and/or IL-10, which is of significance in designing strategies for cytokine-mediated intervention and/or therapy of radiation damage. PMID:10547270

Van Der Meeren, A; Squiban, C; Gourmelon, P; Lafont, H; Gaugler, M H

1999-11-01

277

IL4 down-regulates IL2-, IL3-, and GM-CSF-induced cytokine gene expression in peripheral blood monocytes  

Microsoft Academic Search

Summary IL-4, a product of the T-helper 0 (Th0) and 2 (Th2) subset, was originally described as a B-cell stimulatory factor and has subsequently been found to suppress IL-1a, IL-1?, IL-6, IL-8, and TNF-a gene expression in monocytes stimulated with LPS, and to upregulate IL-1 receptor antagonist (IL1-RA) gene expression. In this study we investigated the effect of IL-4 on

F. H. M. Cluitmans; B. H. J. Esendam; J. E. Landegent; R. Willemze; J. H. F. Falkenburg

1994-01-01

278

Hmgb1-IL-23-IL-17-IL-6-Stat3 axis promotes tumor growth in murine models of melanoma.  

PubMed

In order to understand how tumor cells can escape immune surveillance mechanisms and thus develop antitumor therapies, it is critically important to investigate the mechanisms by which the immune system interacts with the tumor microenvironment. In our current study, IL-17 deficiency results in reduced melanoma tumor size, diminished numbers of proliferating cells and blood vessels, and decreased percentage of CD11b(+)Gr-1(+) MDSCs in tumor tissues. IL-17 promotes IL-6 induction and Stat3 activation. Treatment of Stat3 inhibitor WP1066 in B16-F10 tumor cells inoculated wild-type mice inhibits tumor growth. Additional administration of recombinant IL-6 into B16-F10 tumor-bearing IL-17(-/-) mice results in markedly increased tumor size and p-Stat3 expression, whereas additional recombinant IL-17 administration into B16-F10 tumor-bearing wild-type mice treated with anti-IL-6 mAb does not significantly alter the tumor growth and p-Stat3 expression. In our further study, blockade of Hmgb1-RAGE pathway inhibits melanoma tumor growth and reduces production of IL-23 and IL-17. All these data suggest that Hmgb1-IL-23-IL-17-IL-6-Stat3 axis plays a pivotal role in tumor development in murine models of melanoma, and blocking any portion of this axis will attenuate melanoma tumor growth. PMID:24453427

Tang, Qiu; Li, Jian; Zhu, Hongfei; Li, Pan; Zou, Zhenwei; Xiao, Yin

2013-01-01

279

IL-27 Regulates IL-18 Binding Protein in Skin Resident Cells  

PubMed Central

IL-18 is an important mediator involved in chronic inflammatory conditions such as cutaneous lupus erythematosus, psoriasis and chronic eczema. An imbalance between IL-18 and its endogenous antagonist IL-18 binding protein (BP) may account for increased IL-18 activity. IL-27 is a cytokine with dual function displaying pro- and anti-inflammatory properties. Here we provide evidence for a yet not described anti-inflammatory mode of action on skin resident cells. Human keratinocytes and surprisingly also fibroblasts (which do not produce any IL-18) show a robust, dose-dependent and highly inducible mRNA expression and secretion of IL-18BP upon IL-27 stimulation. Other IL-12 family members failed to induce IL-18BP. The production of IL-18BP peaked between 4872 h after stimulation and was sustained for up to 96 h. Investigation of the signalling pathway showed that IL-27 activates STAT1 in human keratinocytes and that a proximal GAS site at the IL-18BP promoter is of importance for the functional activity of IL-27. The data are in support of a significant anti-inflammatory effect of IL-27 on skin resident cells. An important novel property of IL-27 in skin pathobiology may be to counter-regulate IL-18 activities by acting on keratinocytes and importantly also on dermal fibroblasts. PMID:22761702

Wittmann, Miriam; Doble, Rosella; Bachmann, Malte; Pfeilschifter, Josef; Werfel, Thomas; Mhl, Heiko

2012-01-01

280

Fertile Ground for Astronomy in National Parks  

NASA Astrophysics Data System (ADS)

Light pollution has relegated the non-virtual experience of seeing a starry sky to national parks and other remote areas. Thus, national parks offer an excellent opportunity to advance understanding of and inspiration for astronomical sciences. We relate the experiences of a park ranger, a park scientist, and an astronomy professor who attest to the tremendous public interest in seeing the starry night sky and learning about the cosmos, not in a lab or classroom, but in the natural setting of a park. We review an overall strategy for sustaining this source of inspiration, enhancing public understanding through interpretation, and focusing partnerships toward this untapped potential.

Nordgren, T. E.; Richman, A. M.; Moore, C. A.

2010-08-01

281

New Insights in the Immunobiology of IL-1 Family Members  

PubMed Central

The interleukin-1 (IL 1) family of ligands is associated with acute and chronic inflammation, and plays an essential role in the non-specific innate response to infection. The biological properties of IL 1 family ligands are typically pro-inflammatory. The IL 1 family has 11 family members and can be categorized into subfamilies according to the length of their precursor and the length of the propiece for each precursor (Figure 1). The IL 1 subfamily consists of IL 1?, IL 1?, and IL 33, with the longest propieces of the IL 1 family. IL 18 and IL 37 belong to the IL 18 subfamily and contain smaller propieces than IL 1 and IL-33. Since IL 37 binds to the IL 18R? chain it is part of the IL 18 subfamily, however it remains to be elucidated how the propiece of IL 37 is removed. IL 36?, ?, and ? as well as IL 36 Ra belong to the IL 36 subfamily. In addition, IL 38 likely belongs to this family since it has the ability to bind to the IL 36R. The IL 36 subfamily has the shortest propiece. The one member of the IL 1 family that cannot be categorized in these subfamilies is IL 1 receptor antagonist (IL 1Ra), which has a signal peptide and is readily secreted. In the present review we will describe the biological functions of the IL-1F members and new insights in their biology. PMID:23847614

van de Veerdonk, Frank L.; Netea, Mihai G.

2013-01-01

282

Antiangiogenic and antitumor activities of IL-27.  

PubMed

IL-27 is a novel IL-6/IL-12 family cytokine playing an important role in the early regulation of Th1 responses. We have recently demonstrated that IL-27 has potent antitumor activity, which is mainly mediated through CD8(+) T cells, against highly immunogenic murine colon carcinoma. In this study, we further evaluated the antitumor and antiangiogenic activities of IL-27, using poorly immunogenic murine melanoma B16F10 tumors, which were engineered to overexpress single-chain IL-27 (B16F10 + IL-27). B16F10 + IL-27 cells exerted antitumor activity against not only s.c. tumor but also experimental pulmonary metastasis. Similar antitumor and antimetastatic activities of IL-27 were also observed in IFN-gamma knockout mice. In NOD-SCID mice, these activities were decreased, but were still fairly well-retained, suggesting that different mechanisms other than the immune response are also involved in the exertion of these activities. Immunohistochemical analyses with Abs against vascular endothelial growth factor and CD31 revealed that B16F10 + IL-27 cells markedly suppressed tumor-induced neovascularization in lung metastases. Moreover, B16F10 + IL-27 cells clearly inhibited angiogenesis by dorsal air sac method, and IL-27 exhibited dose-dependent inhibition of angiogenesis on chick embryo chorioallantoic membrane. IL-27 was revealed to directly act on HUVECs and induce production of the antiangiogenic chemokines, IFN-gamma-inducible protein (IP-10) and monokine induced by IFN-gamma. Finally, augmented mRNA expression of IP-10 and monokine induced by IFN-gamma was detected at the s.c. B16F10 + IL-27 tumor site, and antitumor activity of IL-27 was partially inhibited by the administration of anti-IP-10. These results suggest that IL-27 possesses potent antiangiogenic activity, which plays an important role in its antitumor and antimetastatic activities. PMID:16751375

Shimizu, Motomu; Shimamura, Mariko; Owaki, Toshiyuki; Asakawa, Masayuki; Fujita, Koji; Kudo, Motoshige; Iwakura, Yoichiro; Takeda, Yasutaka; Luster, Andrew D; Mizuguchi, Junichiro; Yoshimoto, Takayuki

2006-06-15

283

A Polymorphism in the Coding Region of Il12b promotes IL-12p70 and IL-23 Heterodimer Formation  

PubMed Central

Interleukin (IL)-12 and IL-23 are heterodimeric cytokines involved in the induction of Th1 and Th17 immune responses. Previous work indicated that a region on chromosome 11 encoding the IL-12 p40 subunit regulates strain differences in susceptibility to murine trinitrobenzene sulfonic acid (TNBS)-induced colitis. In addition, this region determines strain differences in LPS induced IL-12 responses. Here we investigated how polymorphisms in the coding region of murine Il12b influence IL-12 and IL-23 heterodimer formation. Transfection studies using constructs containing IL-12p35 linked to either IL-12p40 from the colitis-resistant C57Bl/6 strain or to the polymorphic p40 variant from the colitis-susceptible SJL/J strain demonstrated that SJL/J-derived p40 constructs synthesized significantly more IL-12p70 than constructs harboring the C57Bl/6-p40 variant. This could not be attributed to differences in synthesis rate or secretion implicating a higher affinity of SJL/J derived IL-12p40 for its IL-12p35 subunit. This higher affinity is also associated with increased IL-23 synthesis. In addition, C57Bl/6 mice transgenic for the SJL/J 40 variant synthesized significantly more IL-12p70 and were more prone to develop colonic inflammation than did C57Bl/6 mice transgenic for the C57Bl/6-p40 variant upon LPS challenge. The more efficient binding of the polymorphic Il12b variant to p35 and p19 is most likely due to conformational changes following differential glycosylation as a consequence of the polymorphism. The high synthesis rate of the mature cytokines resulting from this efficient binding can lead to rapid pro-inflammatory skewing of immune responses and distortion of the homeostatic balance underlying the higher susceptibility for colitis. PMID:21321105

Zwiers, Antonie; Fuss, Ivan J.; Seegers, Diana; Konijn, Tanja; Garcia-Vallejo, Juan J.; Samson, Janneke N.; Strober, Warren; Kraal, Georg; Bouma, Gerd

2012-01-01

284

IL BLOCCO EPIDURALE: TECNICA, CONTROINDICAZIONI E COMPLICANZE  

Microsoft Academic Search

Il blocco epidurale va eseguito con tecnica sterile, perci occorre indossare cappello, mascherina e guanti sterili e provvedere ad una accurata disinfezione della cute sovrastante il punto di iniezione. Principi Generali L'identificazione dello spazio epidurale si basa sulla sensazione di perdita di resistenza che si percepisce quando l'ago epidurale passa da un tessuto a maggiore densit (il legamento giallo) ad

Danilo Celleno; Mariagrazia Frigo

285

The Dichotomous Pattern of IL-12R and IL-23R Expression Elucidates the Role of IL-12 and IL-23 in Inflammation  

PubMed Central

IL-12 and IL-23 cytokines respectively drive Th1 and Th17 type responses. Yet, little is known regarding the biology of these receptors. As the IL-12 and IL-23 receptors share a common subunit, it has been assumed that these receptors are co-expressed. Surprisingly, we find that the expression of each of these receptors is restricted to specific cell types, in both mouse and human. Indeed, although IL-12R?2 is expressed by NK cells and a subset of ?? T cells, the expression of IL-23R is restricted to specific T cell subsets, a small number of B cells and innate lymphoid cells. By exploiting an IL-12- and IL-23-dependent mouse model of innate inflammation, we demonstrate an intricate interplay between IL-12R?2 NK cells and IL-23R innate lymphoid cells with respectively dominant roles in the regulation of systemic versus local inflammatory responses. Together, these findings support an unforeseen lineage-specific dichotomy in the in vivo role of both the IL-12 and IL-23 pathways in pathological inflammatory states, which may allow more accurate dissection of the roles of these receptors in chronic inflammatory diseases in humans. PMID:24586521

Dominguez-Punaro, Maria C.; Beauchamp, Claudine; Guyon, Marie-Jose; Charron, Guy; Morin, Nicolas; Sivanesan, Durga; Kuchroo, Vijay; Xavier, Ramnik; Michnick, Stephen W.; Chemtob, Sylvain; Rioux, John D.; Lesage, Sylvie

2014-01-01

286

IL26 gene inactivation in Equidae.  

PubMed

Interleukin-26 (IL26) is a member of the IL10 cytokine family. The IL26 gene is located between two other well-known cytokines genes of this family encoding interferon-gamma (IFNG) and IL22 in an evolutionary conserved gene cluster. In contrast to humans and most other mammals, mice lack a functional Il26 gene. We analyzed the genome sequences of other vertebrates for the presence or absence of functional IL26 orthologs and found that the IL26 gene has also become inactivated in several equid species. We detected a one-base pair frameshift deletion in exon 2 of the IL26 gene in the domestic horse (Equus caballus), Przewalski horse (Equus przewalskii) and donkey (Equus asinus). The remnant IL26 gene in the horse is still transcribed and gives rise to at least five alternative transcripts. None of these transcripts share a conserved open reading frame with the human IL26 gene. A comparative analysis across diverse vertebrates revealed that the IL26 gene has also independently been inactivated in a few other mammals, including the African elephant and the European hedgehog. The IL26 gene thus appears to be highly variable, and the conserved open reading frame has been lost several times during mammalian evolution. PMID:23808390

Shakhsi-Niaei, M; Drgemller, M; Jagannathan, V; Gerber, V; Leeb, T

2013-12-01

287

Parks as a Tool for HIV Management.  

PubMed

Access to parks improves overall health outcomes in the general population. Given that HIV infection has become a chronic disease to manage, among populations engaged in medical care, parks may be promoted as physical activity opportunities in order to manage chronic comorbid conditions. We conducted a cross-sectional examination of the relationships between sociodemographic and biomedical characteristics to park proximity among 635 individuals receiving outpatient HIV care. The data collected included HIV-related biomarkers, depression, and diagnoses of other chronic diseases. The total acres of parks an individual is exposed within one-quarter mile from their home were assessed. The cohort included 635 individuals (67% men, 73% black, and 21% white, mean age 42 years). Unemployment was negatively associated with park availability. Park proximity was not associated with depression or HIV biomarkers. As yet, little effort has been committed to promoting park usage as a low-cost, sustainable method to addressing comorbidities among individuals with HIV. PMID:23995296

Shacham, Enbal; Hipp, J Aaron; Scheuermann, Mary; nen, Nur; Overton, E Turner

2015-01-01

288

Seattle Parks & Recreation Sherwood History Files  

NSDL National Science Digital Library

The Seattle Parks & Recreation Sherwood History Files are the work of one Donald N. Sherwood, who worked as an engineer for the department for 22 years. In the course of his work, he began compiling sketch maps of the parks, and annotating them with historical tidbits and other pieces of information. Also, he began writing individual histories for each facility when the information didn't quite fit on the maps. This site afford interested parties access to these remarkable and truly unusual documents. All told, there are over 80 separate files here, documenting unique pieces of the Seattle parks landscape, including Alki Beach Park, Golden Gardens Park, and the celebrated Gas Works Park on Lake Union. For anyone with an interest in parks and recreation management or the Emerald City, this site will be a most welcome find.

2012-02-14

289

Species in Parks: Flora and Fauna Database  

NSDL National Science Digital Library

The Information Center of the Environment and the US National Park Service (NPS) have developed a "preliminary" data base of vascular plants and vertebrates located on National Park Service Lands. Although the database is not a complete list of species residing on NPS lands, it contains relatively complete lists for both small and large parks. Users can search for plants and animals by species or park name. Within each park, one can search a list of species by taxa (e.g., birds, mammals, fish, etc.) and then learn in what other parks that species is found. Links to the home pages for all NPS property (from American Samoa to Zion National Park) are featured. Both plant and animal databases are available for downloading for Windows or DOS users (.exe).

1997-01-01

290

Exact and efficient calculation of Lagrange multipliers in constrained biological polymers: Proteins and nucleic acids as example cases  

E-print Network

In order to accelerate molecular dynamics simulations, it is very common to impose holonomic constraints on their hardest degrees of freedom. In this way, the time step used to integrate the equations of motion can be increased, thus allowing, in principle, to reach longer total simulation times. The imposition of such constraints results in an aditional set of Nc equations (the equations of constraint) and unknowns (their associated Lagrange multipliers), that must be solved in one way or another at each time step of the dynamics. In this work it is shown that, due to the essentially linear structure of typical biological polymers, such as nucleic acids or proteins, the algebraic equations that need to be solved involve a matrix which is banded if the constraints are indexed in a clever way. This allows to obtain the Lagrange multipliers through a non-iterative procedure, which can be considered exact up to machine precision, and which takes O(Nc) operations, instead of the usual O(Nc3) for generic molecular...

Garca-Risueo, Pablo; Alonso, Jos Luis

2011-01-01

291

Il ruolo di Guglielmo Marconi  

Microsoft Academic Search

\\u000a Marconi, come risulta dai verbali, non era molto assiduo alle riunioni del Direttorio del CNR. In quel periodo, nonostante\\u000a il manifestarsi dei primi sintomi dellamalattia cardiaca che lavrebbe condotto alla morte nel 1937, continuava a dividersi\\u000a fra numerosi impegni: la Reale Accademia dItalia di cui era stato nominato da poco presidente, la costruzione della prima\\u000a stazione radio del Vaticano, gli

Franco Foresta Martin; Geppi Calcara

292

Structural and Biophysical Studies of the Human IL-7/IL-7R[alpha] Complex  

SciTech Connect

IL-7 and IL-7R{alpha} bind the {gamma}{sub c} receptor, forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells. We report that the IL-7R{alpha} ectodomain uses glycosylation to modulate its binding constants to IL-7, unlike the other receptors in the {gamma}{sub c} family. IL-7 binds glycosylated IL-7R{alpha} 300-fold more tightly than unglycosylated IL-7R{alpha}, and the enhanced affinity is attributed primarily to an accelerated on rate. Structural comparison of IL-7 in complex to both forms of IL-7R{alpha} reveals that glycosylation does not participate directly in the binding interface. The SCID mutations of IL-7R{alpha} locate outside the binding interface with IL-7, suggesting that the expressed mutations cause protein folding defects in IL-7R{alpha}. The IL-7/IL-7R{alpha} structures provide a window into the molecular recognition events of the IL-7 signaling cascade and provide sites to target for designing new therapeutics to treat IL-7-related diseases.

McElroy, Craig A.; Dohm, Julie A.; Walsh, Scott T.R.; (OSU); (UPENN)

2009-03-06

293

The equations of Lagrange for a continuous deformable body with rigid body degrees of freedom, written in a momentum based formulation  

NASA Astrophysics Data System (ADS)

The present paper is concerned with Lagrange's Equations, applied to a deformable body in the presence of rigid body degrees of freedom. The Lagrange description of Continuum Mechanics is used. An exact version of the Equations is derived first. This version, which represents an identical extension of the Fundamental Law of Dynamics, does involve the idea of virtual motions. The virtual motion is described in the framework of the Ritz-Ansatz, but our derivation does not make use of D'Alemberts principle, the principle of virtual work, or variational principles. From the exact version, by involving arguments related to the Galerkin approximation technique, we derive an approximate Ritz type version of Lagrange's Equations. This approximate version coincides with the traditional one, which is based on the notion of kinetic energy. However, since our derivation stems from the Fundamental Law of Dynamics, we have at our disposal an alternative formulation, which is based on the notion of local momentum. This momentum based version, which is the main topic of the present contribution, can be used for the purpose of performing independent checks of the energy based version of Lagrange's Equations. The momentum based version also clarifies that and how certain terms in the energy based version do cancel out. The momentum based version is worked out in the framework of the Floating Frame of Reference Formulation of Multibody Dynamics. Explicit formulas for the single terms of Lagrange's Equations are derived for the translational, rotational and flexible degrees of freedom of the deformable body, respectively. Corresponding Lagrange's Equations are explained in the light of the relations of Balance of Total Momentum, Balance of Total Moment of Momentum, of the Mean Stress Theorem and the notion of Virial of Forces. An embedding into the literature is given.

Irschik, H.; Krommer, M.; Nader, M.; Vetyukov, Y.; von Garssen, H.-G.

2015-01-01

294

Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor.  

PubMed

IL-2R, IL-4R, and IL-7R share a common subunit referred to as gamma c and the IL-13R has been proposed to contain gamma c as a subunit. In this report we have used two novel mAbs (3E12 and 4G3) to distinct epitopes of mouse gamma c to determine its lymphoid cell distribution and to examine whether gamma c uses similar epitopes to interact with different cytokines and cytokine receptors. FACS analysis revealed that gamma c is expressed in most lymphocytes, myeloid cells, embryonic thymocytes, and lymphoid cell lines. Results from radiolabeled ligand binding studies, biochemical analysis of ligand-receptor cross-linked complexes, and cytokine bioassays indicate that the epitope defined by mAb 4G3 closely defines the IL-7 binding region of gamma c and overlaps the IL-2 binding region of gamma c. These studies also indicate that gamma c interacts with IL-4 in the context of the IL-4R in a manner that is distinct from its role in the IL-2R and IL-7R and suggest that the 3E12 epitope defines a region of gamma c that intimately interacts with the IL-4R. The B9 plasmacytoma, which proliferates in response to IL-4 and IL-13, was shown to not express gamma c. Thus, at least in some circumstances, gamma c is dispensable for signaling via the IL-4R and is not a required subunit of the IL-13R. PMID:7530740

He, Y W; Adkins, B; Furse, R K; Malek, T R

1995-02-15

295

Hyde Park Herald Digital Collections  

NSDL National Science Digital Library

Hyde Park is a well-known urban neighborhood eight miles south of Chicago's Loop, and residents in and around the neighborhood have a long tradition of independent journalism. The Hyde Park Herald was started in 1882, and it documented the community's earliest history, including the years before the neighborhood was annexed to Chicago. Recently, a group of concerned citizens donated money to digitize the newspaper's back issues, and it was done to celebrate the leadership of Bruce Sagan, who has published the newspaper since 1953. Visitors can view the newspaper from 1882 to the present day, and despite a gap between the years 1889 and 1918, the coverage is quite good. Some good starting points include the WWII years and the late 1950s, which was when the first urban renewal project started in the neighborhood. Also, visitors may wish to perform a detailed search across the entire collection and then can also learn a bit more about the paper's history here.

296

National Park Service Web Cameras  

NSDL National Science Digital Library

The National Park Service (NPS) operates digital cameras at many parks in the lower 48 states, Alaska, and Hawaii to help educate the public on air quality issues. These cameras often show the effects of air pollution, especially visibility impairment. Because the cameras are typically located near air quality monitoring sites, their web pages display other information along with the photo, such as current levels of ozone, particulate matter, or sulfur dioxide, visual range, and weather conditions. The digital photos are usually updated every 15 minutes, while air quality data values are revised hourly. Charts of the last ten days of hourly weather, ozone, particulate matter, or sulfur dioxide data are also available. The cameras are accessible by clicking on an interactive map.

297

Oregon State Parks and Recreation  

NSDL National Science Digital Library

What can you do in the great Oregon outdoors? From the world of Cannon Beach to the wild and rugged Snake River, the experiences are diverse, to say the least. The homepage features dramatic vistas, isolated lighthouses, and a whole range of wonderful images to entice visitors. In the Visit area, there is an interactive map of the state that will help plan any trip. Here visitors can select Activities and Facilities to look for specific amenities. Moving along, the Event Calendar area allows visitors to look for upcoming events at a specific park or by category. Policy folks will appreciate the About Us area, as it includes detailed information on the Oregon Parks and Recreation Department's budget, their annual report, information about upcoming initiatives, and construction projects.

298

Biological significance of soluble IL-2 receptor  

PubMed Central

A NUMBER of receptors for growth factors and differentiation antigens have been found to be secreted or released by cells. Following mononuclear cell (MNC) activation and interleukin-2 receptor (IL-2R) expression, a soluble form of the Alpha;-chain of IL-2R (sIL-2R) is released. The sIL-2R has been shown to be present in the culture supernatants of activated MNCs as well as in normal sera and, in higher amounts, in sera from subjects affected by several diseases including neoplastic, infectious and autoimmune ones, and in sera from transplanted patients suffering allograft rejection. The blood sIL-2R levels depend on the number of producing cells and the number of molecules per cell, so that sIL-2R blood values may represent an index of the number and the functional state of producing cells, both normal and neoplastic. Thus, monitoring of the immune system, mostly T-cells and haematological malignancies might be targets for the measurement of sIL-2R. Since many conditions may influence sIL-2R production, little diagnostic use may result from these measurements. However, since blood sIL-2R levels may correlate with disease progression and/or response to therapy, their measurement may be a useful index of activity and extent of disease. The precise biological role of the soluble form of the IL-2R is still a matter of debate. However, we know that increased sIL-2R levels may be observed in association with several immunological abnormalities and that sIL-2R is able to bind IL-2. It is conceivable then that in these conditions the excess sIL-2R released in vivo by activated lymphoid cells or by neoplastic cells may somehow regulate IL-2-dependent processes. On the other hand, it cannot exclude that sIL-2R is a by-product without biological significance. Finally, it is puzzling that in many conditions in which an increase of blood sIL-2R values has been observed, MNCs display a decreased in vitro capacity to produce sIL-2R. These seemingly contrasting findings are discussed in the light of the data showing that sIL-2R production correlates with IL-2 production. PMID:18475497

Candore, Giuseppina; Cigna, Diego; Colucci, Antonio Tobia; Modica, Maria Assunta

1993-01-01

299

Yellowstone National Park Online Tours  

NSDL National Science Digital Library

This Yellowstone National Park website provides an array of online tours, videos, and other information. Nature and history tours are among those featured on the site. The nature tours cover the Old Faithful area, the Norris Geyser Basin, the Fountain Paint Pots, the Mammoth Hot Springs, and the Grand Canyon of the Yellowstone. Each of these tours highlights prominent natural features with photos and descriptions.

Park, Yellowstone N.

300

Role of interleukin-23 (IL23) receptor signaling for IL17 responses in human Lyme disease  

Microsoft Academic Search

Interleukin-23 (IL-23) is known to play a crucial role in the development and maintenance of T helper 17 cells. It has been previously demonstrated that IL-17 is involved in experimental Lyme arthritis, caused by Borrelia burgdorferi bacteria. However, the precise role of the IL-23 receptor (IL-23R) for the B. burgdorferi-induced IL-17 responses or human Lyme disease has not yet been

M. Oosting; H. J. M. ter Hofstede; F. L. van de Veerdonk; P. D. J. Sturm; B. J. Kullberg; M. G. Netea; L. A. B. Joosten

2011-01-01

301

Genetic epistasis of IL23/IL17 pathway genes in Crohns disease  

PubMed Central

The IL23/IL17 pathway is pivotal in the development of chronic mucosal inflammation seen in Crohns disease (CD). Genetic variants in the IL23R and IL12B have been associated with CD susceptibility. We investigated ten genes within the IL23/IL17 pathway in a case-control study of 763 CD cases and 254 healthy controls. We identified novel association in haplotypes in IL17A (empirical p value = 0.02), IL17RA (p = 0.001), IL17RD (p = 0.001), IL12RB1 (p = 0.003) and IL12RB2 (p = 0.001) as well as confirming the association with IL12B variants (p = 0.003). The cumulative risk for carrying increased number of CD risk haplotypes from genes in this pathway rises to an odds ratio of 4.3 for carrying 5 risk haplotypes. We have previously demonstrated an association between this cohort and IL23R haplotypes. Pairwise analyses suggest that there is statistical interaction between variants in IL17A and IL23R (p = 0.047) and between variants in IL17RA and IL23R (p = 0.036). Furthermore, a significant association between CD and the widely replicated IL23R variants is only seen in the presence of IL17A or IL17RA variants. These data support the investigation of pathways implicated in CD pathogenesis in order to identify further susceptibility genes and also suggest that important gene-gene interaction is present in CD susceptibility. PMID:19235914

McGovern, Dermot P.B.; Rotter, Jerome I.; Mei, Ling; Haritunians, Talin; Landers, Carol; Derkowski, Carrie; Dutridge, Deb; Dubinsky, Marla; Ippoliti, Andy; Vasiliauskas, Eric; Mengesha, Emebet; King, Lily; Pressman, Sheila; Targan, Stephan R.; Taylor, Kent D.

2010-01-01

302

Coordinating OBS Parks in Europe  

NASA Astrophysics Data System (ADS)

Within Europe there are more than 380 Ocean Bottom Seismometers (OBS) distributed across 10 instrument parks in 6 countries. At least 120 of these OBS are wideband or broadband, over 260 can be deployed for at least 6 months at a time and 140 for at least one year. New parks are planned in two other European countries, which should add over 70 OBSs to this "fleet". However, these parks are under the control of individual countries or universities and hence to date this has made it difficult to organize large-scale experiments, especially for seismologists without marine experience. There has recently been an initiative to coordinate the use of these distributed instruments and their data products, to encourage large-scale experiments, possibly with onshore and offshore components, by seismologists who have not necessarily used OBSs before. The ongoing or planned developments include: Helping scientists with marine-specific formalities such as ship requests; clearer explanations of the noise floors of OBS instrumentation; improved clarity of instrument pricing and availability; standardized data output formats and data validation; and archiving in established seismological data centers. These efforts should allow improved experiment design in scientifically interesting regions with an offshore component and an easier, clearer way to organize large-scale, multi-country experiments. We will present details of this initiative to help organize large-scale experiments, the particularities of OBS sensors and marine deployments, the available instrumentation and new developments.

Crawford, W.; Brisbourne, A.; D'Anna, G.; Flh, E. R.; Galve, A.; Graindorge, D.; Harmon, N.; Henstock, T.; Klingelhfer, F.; Mangano, G.; Matias, L.; Peirce, C.; Sallares, V.; Schmidt-Aursch, M.; Tilmann, F.; Voss, P.

2012-04-01

303

Second trimester maternal plasma levels of cytokines IL-1Ra, Il-6 and IL-10 and preterm birth  

PubMed Central

Objective To examine the interaction of the cytokines interleukin-1 receptor antagonist (IL)-1Ra, IL-6 and IL-10 to predict preterm birth (PTB) in pregnant Hispanic women (n = 470). Study Design In this prospective study, demographic data were obtained prenatally and birth outcome data were obtained from the medical chart. Cytokines were measured from plasma obtained at 22 to 24 weeks gestation. Data analysis utilized logistic regression. Result PTB was predicted by level of IL-1Ra (odds ratio (OR) = 2.55; 95% confidence interval (CI) = 1.24, 5.24). The interaction between IL-1Ra and IL-6 and between IL-1Ra and IL-10 was significant (Wald = 4.01, P = 0.04 and Wald = 8.84, P<0.003, respectively) and was also predictive of PTB. As IL-1Ra levels increased while IL-10 levels were low, the probability of PTB greatly increased. Conclusion The interactions of select cytokines and cytokine receptor antagonists were associated with PTB. Future research should focus on the changes in cytokines during pregnancy to identify critical periods of change, and examine predictors of the cytokine response. PMID:22460542

Ruiz, RJ; Jallo, N; Murphey, C; Marti, CN; Godbold, E; Pickler, RH

2012-01-01

304

The Potential for Pocket Parks to Increase Physical Activity  

PubMed Central

Purpose To assess the use of new pocket parks in low-income neighborhoods. Setting Los Angeles Subjects Parks users and residents living within mile of 3 pocket parks and 15 neighborhood parks Intervention The creation of pocket parks Design Quasi-experimental post-only comparison Measures We used the System of Observing Play and Recreation in Communities (SOPARC) to measure park use and park-based physical activity and surveyed park users and residents about their park use. Analysis We surveyed 392 and 432 household members within one-half mile of the 3 pocket parks before and after park construction, respectively, as well as 71 pocket park users and compared them to 992 neighborhood park users and 342 residents living within mile of other neighborhood parks. We compared pocket park use to playground area use in the larger neighborhood parks. We used descriptive statistics and Generalized Estimating Equations for the analysis. Results Overall, pocket park use compared favorably in promoting moderate-to-vigorous physical activity with that of existing playground space in nearby parks and they were cost-effective at $0.73/MET hour gained. Pocket park visitors walked an average of 0.25 miles to get there. Conclusions Pocket parks, when perceived as attractive and safe destinations, may increase physical activity by encouraging families with children to walk there. Additional strategies and programs may be needed to encourage more residents to use the parks. PMID:24380461

Cohen, Deborah A.; Marsh, Terry; Williamson, Stephanie; Han, Bing; Derose, Kathryn Pitkin; Golinelli, Daniella; McKenzie, Thomas L.

2014-01-01

305

Simultaneous dissection and comparison of IL-2 and IL-15 signaling pathways by global quantitative phosphoproteomics.  

PubMed

Common ?-chain family of cytokines (IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, where IL stands for interleukin) are key regulators of the immune homeostasis that exhibit pleiotropic biological activities and even sometimes redundant roles as a result of the utilization of the same receptor subunit. However, they also exert distinct functions that make each of them to be indispensable. For instance, all family members can act as T-cell growth factors; however, we found that IL-15 but not IL-7 can replace IL-2 to promote and sustain the proliferation of Kit225T cells. In addition to the ?-chain, IL-2 and IL-15 share the ?-chain, which creates the paradox of how they can trigger diverse phenotypes despite signaling through the same receptors. To investigate this paradigm, we combined SILAC with enrichment of tyrosine-phosphorylated proteins and peptides followed by mass spectrometric analysis to quantitatively assess the signaling networks triggered downstream IL-2/IL-2R and IL-15/IL-15R. This study confirmed that the transduction pathways initiated by both cytokines are highly similar and revealed that the main signaling branches, JAK/STAT, RAS/MAPK and PI3K/AKT, were nearly equivalently activated in response to both ILs. Despite that, our study revealed that receptor internalization rates differ in IL-2- and IL-15-treated cells indicating a discrete modulation of cytokine signaling. All MS data have been deposited in the ProteomeXchange with identifier PXD001129 (http://proteomecentral.proteomexchange.org/dataset/PXD001129). PMID:25142963

Osinalde, Nerea; Sanchez-Quiles, Virginia; Akimov, Vyacheslav; Guerra, Barbara; Blagoev, Blagoy; Kratchmarova, Irina

2015-01-01

306

IL-4 acts as a homeostatic regulator of IL-2-induced TNF and IFN-gamma.  

PubMed Central

Interleukin-4 (IL-4) is a cytokine secreted by interleukin-2 (IL-2)-activated lymphocytes. IL-2-stimulated lymphocytes also secrete two cytokines, tumour necrosis factor (TNF) and gamma-interferon (IFN-gamma), which contribute to effector function and which may themselves recruit fresh, cytokine-secreting effector cells. We have now investigated whether the IL-4 induced is able to homeostatically regulate secretion of the TNF and IFN-gamma. Peripheral blood mononuclear cells or lymphocytes from normal donors and from patients with neoplastic disease were cultured in the presence of IL-2 alone, IL-4 alone or with both cytokines. IL-2 induced high levels of TNF and IFN-gamma secretion in both groups. The addition of recombinant IL-4 to these IL-2-stimulated cultures lead to significant inhibition of IFN-gamma and TNF production. IFN-gamma secretion was reduced by 50-99% in normal donors and by between 11% and 99% in patients (P less than 0.001). TNF levels induced by IL-2 were similarly reduced by IL-4 both in normal donors (P less than 0.003) and in patients (P less than 0.01). These inhibitory effects were produced by IL-4 at doses of IL-2 attainable in vivo. Inhibition appears to represent a homeostatic regulatory mechanism which may limit recruitment of fresh activated killer (AK) cells. When endogenous IL-4 activity in IL-2-activated lymphocytes was blocked by anti-IL-4 antibody, significantly higher levels of IFN-gamma and TNF were secreted (P less than 0.05). Since both TNF and IFN-gamma may contribute to the anti-neoplastic action of IL-2, manipulating the level of IL-4 activity in vivo could augment the benefits of IL-2 immunotherapy. PMID:1901829

Bello-Fernandez, C; Oblakowski, P; Meager, A; Duncombe, A S; Rill, D M; Hoffbrand, A V; Brenner, M K

1991-01-01

307

The interleukin (IL)-31/IL-31R axis contributes to tumor growth in human follicular lymphoma.  

PubMed

Interleukin (IL)-31A binds to an heterodimer composed of IL-31 receptor A (IL-31RA) and Oncostatin M Receptor (OSMR). The IL-31/IL-31R complex is involved in the pathogenesis of various skin diseases, including cutaneous T-cell lymphoma. No information is available on the relations between the IL-31/IL-31R complex and B-cell lymphoma. Here we have addressed this issue in follicular lymphoma (FL), a prototypic germinal center(GC)-derived B-cell malignancy. IL-31 enhanced primary FL cell proliferation through IL-31R-driven signal transducer and activator of transcription factor 1/3 (STAT1/3), extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt phosphorylation. In contrast, GC B cells did not signal to IL-31 in spite of IL-31R expression. GC B cells expressed predominantly the inhibitory short IL-31RA isoform, whereas FL cells expressed predominantly the long signaling isoform. Moreover, GC B cells lacked expression of other IL-31RA isoforms potentially involved in the signaling pathway. IL-31 protein expression was significantly higher in surface membrane than in cytosol of both FL and GC B cells. IL-31 was detected in plasma membrane microvesicles from both cell types but not released in soluble form in culture supernatants. IL-31 and IL-31RA expression was higher in lymph nodes from FL patients with grade IIIa compared with grade I/II, suggesting a paracrine and/or autocrine role of IL-31/IL-31RA complex in tumor progression through microvesicle shedding.Leukemia advance online publication, 28 October 2014; doi:10.1038/leu.2014.291. PMID:25283844

Ferretti, E; Tripodo, C; Pagnan, G; Guarnotta, C; Marimpietri, D; Corrias, M V; Ribatti, D; Zupo, S; Fraternali-Orcioni, G; Ravetti, J L; Pistoia, V; Corcione, A

2014-10-01

308

ACCERTAMENTO SAPERI MINIMI CORSO DI LAUREA IN LINGUE E CULTURE PER IL TURISMO E IL COMMERCIO INTERNAZIONALE  

E-print Network

ACCERTAMENTO SAPERI MINIMI CORSO DI LAUREA IN LINGUE E CULTURE PER IL TURISMO E IL COMMERCIO;ACCERTAMENTO SAPERI MINIMI CORSO DI LAUREA IN LINGUE E CULTURE PER IL TURISMO E IL COMMERCIO INTERNAZIONALE a

Romeo, Alessandro

309

3249 S. Oak Park Ave., Berwyn, IL 60402 MacNeal Hospital  

E-print Network

OR if there was a positive TB skin test, there must be documentation of a negative chest x-ray. If a rotator has a positive TB skin test and a positive chest x-ray, that rotator must meet with Dr. Mark Levin to discuss

Alford, Simon

310

Geology Fieldnotes: Theodore Roosevelt National Park, North Dakota  

NSDL National Science Digital Library

This Theodore Roosevelt National Park site contains park geology information, park maps, photographs, related links, visitor information, and teacher features (resources for teaching geology with National Park examples). The park geology section discusses the Park's geologic history and the region's role in shaping Theodore Roosevelt's conservation efforts while he was President. The section also contains a link to information on the geology of Theodore Roosevelt National Park. The park maps section contains an area map as well as two maps detailing the North and South Units of the Park.

311

IL-15 deficient tax mice reveal a role for IL-1? in tumor immunity.  

PubMed

IL-15 is recognized as a promising candidate for tumor immunotherapy and has been described as both a promoter of cancer and a promoter of anti-cancer immunity. IL-15 was discovered in cells transformed by HTLV-1, the etiologic agent of adult T cell leukemia/lymphoma (ATL) and the human retrovirus that carries the Tax oncogene. We have developed the TAX-LUC mouse model of ATL in which Tax expression drives both malignant transformation and luciferase expression, enabling non-invasive imaging of tumorigenesis in real time. To identify the role of IL-15 in spontaneous development of lymphoma in vivo, an IL-15(-/-) TAX-LUC strain was developed and examined. The absence of IL-15 resulted in aggressive tumor growth and accelerated mortality and demonstrated that IL-15 was not required for Tax-mediated lymphoma but was essential for anti-tumor immunity. Further analysis revealed a unique transcriptional profile in tumor cells that arise in the absence of IL-15 that included a significant increase in the expression of IL-1? and IL-1?-regulated cytokines. Moreover, anti-IL-1? antibodies and an IL-1 receptor antagonist (Anakinra) were used to interrogate the potential of IL-1? targeted therapies in this model. Taken together, these findings identify IL-15 and IL-1? as therapeutic targets in lymphoma. PMID:24416335

Rauch, Daniel A; Harding, John C; Ratner, Lee

2014-01-01

312

The Possible Role of the Novel Cytokines IL-35 and IL-37 in Inflammatory Bowel Disease  

PubMed Central

Interleukin- (IL-) 35 and IL-37 are newly discovered immune-suppressing cytokines. They have been described in inflammatory diseases such as collagen-induced arthritis and asthma. However, their expressions in inflammatory bowel disease (IBD) patients have not been yet explored. Our aim was to evaluate serum and inflamed mucosal levels in IBD patients. In 20 ulcerative colitis (UC) patients, 7 Crohn's disease (CD) patients, and 15 healthy subjects, cytokine levels in serum were determined using ELISA and mucosal expression studies were performed by immunohistochemistry, quantitative real-time PCR, and Western blot. The results showed that serums IL-35 and IL-37 levels were significantly decreased in UC and CD patients compared with healthy subjects. The cytokines levels correlated inversely with UC activity. IL-35 was expressed in infiltrating immune cells while IL-37 in intestinal epithelial cells as well as inflammatory cells. IBD patients had significantly higher Ebi3, p35 (two subunits of IL-35), and IL-37b gene expressions; IL-35 and IL-37 protein expressions were higher in IBD patients compared with controls. The study showed that serums IL-35 and IL-37 might be potentially novel biomarkers for IBD. Intestinal IL-35 and IL-37 proteins are upregulated, suggesting that regulating the expression of the two cytokines may provide a new possible target for the treatment of IBD. PMID:25214710

Li, Yanmei; Wang, Yanan; Liu, Ying; Wang, Yatian; Zuo, Xiuli; Li, Yanqing; Lu, Xuefeng

2014-01-01

313

The cytokines (IFN-gamma, IL-2, IL-4, IL-10, IL-17) and Treg cytokine (TGF-beta1) levels in adults with immune thrombocytopenia.  

PubMed

Previous studies have indicated that autoimmune diseases might be caused by an imbalance of T helper cells (Th), cytokines, and regulatory T cells (Treg) cytokines. We measured the plasma concentrations of Th1-associated cytokines (IFN-gamma, IL-2), Th2 -associated cytokines (IL-4, IL-10), Th17-associated cytokine (IL-17) and Treg -associated cytokine (TGF-beta1) in adult patients with immune thrombocytopenia (ITP) and evaluated their clinical relevance. Plasma IFN-gamma, IL-2, IL-4, IL-10, IL-17 and TGF-beta1 concentrations of 52 ITP patients and 30 age- and sex-matched healthy controls were measured by enzyme-linked immunosorbent assay method (ELISA). Concentration of Th2 cytokines (IL-4 and IL-10) were significantly higher in ITP patients compared to controls (P < 0.05). However, concentrations of Th1 cytokines (IFN-gamma, IL-2), Th17 cytokine (IL-17) and Treg cytokine (TGF-beta1) were lower in ITP patients (P < 0.05). Concentration of IL-17 was significantly higher in chronic ITP patients compared to severe ITP patients (P < 0.05), and no significant difference of cytokine concentration among the other subgroups in ITP patients was found. Among the ITP patients, concentration of IFN-gamma correlated positively and significantly with PAIgG (r = 0.48, P = 0.02). A significant correlation was neither found between other cytokine levels and platelet count, nor between cytokine levels and megakaryocytes number, nor between cytokines levels and PAIgG or GPIIb/IIIa and/or GPIb/IX autoantibodies. The present study demonstrates that an imbalance of Th and Treg cytokines may mediate the pathogenesis of ITP. PMID:25272942

Ma, Liangliang; Liang, Yan; Fang, Meiyun; Guan, Yanchun; Si, Yang; Jiang, Feng; Wang, Fangting

2014-09-01

314

Geology Fieldnotes: Mesa Verde National Park, Colorado  

NSDL National Science Digital Library

This National Park Service (NPS) site provides information about Mesa Verde National Park in southwestern Colorado, including geology, visitor information, illustrations, and additional links for more details. This park was home to the Anasazi people who were cliff dwellers in this area. Today you can see artifacts, native dwellings made of sandstone bricks, and learn about the Anasazi way of life, dating back to around 550 AD.

315

updated August 1, 2012 -Motorcycle Parking  

E-print Network

Parking Only Hope Lodge Parking Only Moffitt Valet Parking Only 38B 38C 38G 43A 12 38D 38E38B 38F 38T 38A Library LIB David C. Anchin Center DAC Theatre II THR Theatre I TAT Dance FAD Fine Arts Studio FAS Art Center BPT Catholic Center CTH Hillel Jewish Student Center HIL Chapel Center CHA Crosswinds Wesley

Meyers, Steven D.

316

Disabled Parking & Access Plan Campus Disabled Persons (DP)  

E-print Network

· Develop and Maintain DP Parking Campus Map on Web and in Handouts · Define, Document and Prioritize AllDisabled Parking & Access Plan Campus Disabled Persons (DP) Parking and Access Plan For CSU Parking Spaces = 10,873 · Total DP Parking Spaces = 201 (1.8%) ­ Total Van Accessible Spaces = 37 (0

de Lijser, Peter

317

Geology Fieldnotes: Death Valley National Park, California/Nevada  

NSDL National Science Digital Library

This Death Valley National Park site contains park geology information, park maps, photographs, visitor information, and teacher features (resources for teaching geology using National Park examples). The Park Geology section contains an exaggerated cross-section showing the vertical rise within Death Valley. A link is provided to Death Valley's expanded geology page.

318

IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells.  

PubMed

Osteosarcoma (OS) is the most common human primary malignant bone tumor in children and young adults with poor prognosis because of their high metastatic potential. Identification of key factors that could regulate the aggressive biologic behavior of OS, particularly with respect to metastasis, would be necessary if significant improvements in therapeutic outcome are to occur. In this study, we carefully evaluated the potential role of IL-17A/IL-17RA interaction in metastasis of OS. We found that serum IL-17A was higher in OS patients with metastasis and was associated with their clinical stage. The elevated expression of IL-17RA was observed in tumor tissue from OS patients with metastasis. Of note, we showed that IL-17A could promote the metastasis of U-2 OS cells which expression high IL-17RA, but not MG63 cells which expression low IL-17RA. Further, we revealed that downregulation of IL-17RA in U-2 cells could abrogated the enhanced metastasis induced by IL-17A, while upregulation of IL-17RA in MG63 cells could elevate their response to IL-17A and exerted enhanced metastasis. We observed that IL-17A/IL-17RA interaction promoted the expression of VEGF, MMP9 and CXCR4 in OS cells, which might partly explain the enhanced metastasis of OS cells. Furthermore, we showed that Stat3 activity was crucial for IL-17A/IL-17RA interaction to promote OS metastasis. Finally, we confirmed that IL-17A/IL-17RA interaction promoted the metastasis of OS in nude mice. Our findings might provide a mechanistic explanation for metastasis of OS in vivo, and suggested that targeting IL-17A signaling was a novel promising strategy to treat patients with OS. PMID:23192273

Wang, Mingmin; Wang, Luanqiu; Ren, Tao; Xu, Lin; Wen, Zhenke

2013-02-01

319

Computational methods of Gaussian Particle Swarm Optimization (GPSO) and Lagrange Multiplier on economic dispatch issues (case study on electrical system of Java-Bali IV area)  

NASA Astrophysics Data System (ADS)

The objective in this paper is about economic dispatch problem of electric power generation where scheduling the committed generating units outputs so as to meet the required load demand at minimum operating cost, while satisfying all units and system equality and inequality constraint. In the operating of electric power system, an economic planning problem is one of variables that its must be considered since economically planning will give more efficiency in operational cost. In this paper the economic dispatch problem which has non linear cost function solved by using swarm intelligent method is Gaussian Particle Swarm Optimization (GPSO) and Lagrange Multiplier. GPSO is a population-based stochastic algorithms which their moving inspired by swarm intelligent and probabilities theories. To analize its accuracy, the economic dispatch solution by GPSO method will be compared with Lagrange multiplier method. From the running test result the GPSO method give economically planning calculation which it better than Lagrange multiplier method and the GPSO method faster to getting error convergence. Therefore the GPSO method have better performance to getting global best solution than the Lagrange method.

Komsiyah, S.

2014-03-01

320

Science Enabled by the Ares V: A Large Monolithic Telescope Placed at the Second Sun-Earth Lagrange Point  

NASA Technical Reports Server (NTRS)

The payload mass and volume capabilities of the planned Ares V launch vehicle provide the science community with unprecedented opportunities to place large science payloads into low earth orbit and beyond. One example, the outcome of a recent study conducted at the NASA Marshall Space Flight Center, is a large, monolithic telescope with a primary mirror diameter of 6.2 meters placed into a halo orbit about the second Sun-Earth Lagrange point, or L2, approximately 1.5 million kin beyond Earth's orbit. Operating in the visible and ultraviolet regions of the electromagnetic spectrum, such a large telescope would allow astronomers to detect bio-signatures and characterize the atmospheres of transiting exoplanets, provide high resolution imaging three or more times better than the Hubble Space Telescope and the James Webb Space Telescope, and observe the ultraviolet light from warm baryonic matter.

Hopkins, Randall C.; Stahl, H. Philip

2007-01-01

321

Evaluation of a transient, simultaneous, arbitrary Lagrange-Euler based multi-physics method for simulating the mitral heart valve.  

PubMed

A transient multi-physics model of the mitral heart valve has been developed, which allows simultaneous calculation of fluid flow and structural deformation. A recently developed contact method has been applied to enable simulation of systole (the stage when blood pressure is elevated within the heart to pump blood to the body). The geometry was simplified to represent the mitral valve within the heart walls in two dimensions. Only the mitral valve undergoes deformation. A moving arbitrary Lagrange-Euler mesh is used to allow true fluid-structure interaction (FSI). The FSI model requires blood flow to induce valve closure by inducing strains in the region of 10-20%. Model predictions were found to be consistent with existing literature and will undergo further development. PMID:22640492

Espino, Daniel M; Shepherd, Duncan E T; Hukins, David W L

2014-01-01

322

75 FR 20885 - National Park Week, 2010  

Federal Register 2010, 2011, 2012, 2013

...Proclamation 8498--National Park Week, 2010 Proclamation 8499--National Crime Victims' Rights Week, 2010 Proclamation 8500--National Volunteer Week, 2010 Proclamation 8501--National Day of Service and...

2010-04-21

323

WIND DATA REPORT Deer Island Parking Lot  

E-print Network

............................................................................................................................ 1 Table of Figures............................................................................................................. 4 SECTION 4 - Significant Meteorological Events........................................................................................................................ 16 TABLE OF FIGURES Figure 1 - Site location at Deer Island Parking Lot site................

Massachusetts at Amherst, University of

324

IL-13 but not IL-4 signaling via IL-4R? protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis  

PubMed Central

Interleukin 4 (IL-4) was shown to be tumor-promoting in full carcinogenesis studies using 3-methylcholanthrene (MCA). Because heretofore the role of IL-4 in DMBA/TPA (9,10-dimethyl-1,2-benz-anthracene/12-O-tetradecanoylphorbol-13-acetate) two-stage carcinogenesis was not studied, we performed such experiments using either IL-4?/? or IL-4R??/? mice. We found that IL-4R??/? but not IL-4?/? mice have enhanced papilloma formation, suggesting that IL-13 may be involved. Indeed, IL-13?/? mice developed more papillomas after exposure to DMBA/TPA than their heterozygous IL-13-competent littermate controls. However, when tested in a full carcinogenesis experiment, exposure of mice to 25 ?g of MCA, both IL-13?/? and IL-13+/? mice led to the same incidence of tumors. While IL-4 enhances MCA carcinogenesis, it does not play a measurable role in our DMBA/TPA carcinogenesis experiments. Conversely, IL-13 does not affect MCA carcinogenesis but protects mice from DMBA/TPA carcinogenesis. One possible explanation is that IL-4 and IL-13, although they share a common IL-4R? chain, regulate signaling in target cells differently by employing distinct JAK/STAT-mediated signaling pathways downstream of IL-13 or IL-4 receptor complexes, resulting in different inflammatory transcriptional programs. Taken together, our results indicate that the course of DMBA/TPA- and MCA-induced carcinogenesis is affected differently by IL-4 versus IL-13-mediated inflammatory cascades. PMID:24403255

Rothe, Michael; Quarcoo, David; Chashchina, Anna A; Bozrova, Svetlana V; Qin, Zhihai; Nedospasov, Sergei A; Blankenstein, Thomas; Kammertoens, Thomas; Drutskaya, Marina S

2013-01-01

325

IL-13 but not IL-4 signaling via IL-4R? protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis.  

PubMed

Interleukin 4 (IL-4) was shown to be tumor-promoting in full carcinogenesis studies using 3-methylcholanthrene (MCA). Because heretofore the role of IL-4 in DMBA/TPA (9,10-dimethyl-1,2-benz-anthracene/12-O-tetradecanoylphorbol-13-acetate) two-stage carcinogenesis was not studied, we performed such experiments using either IL-4(-/-) or IL-4R?(-/-) mice. We found that IL-4R?(-/-) but not IL-4(-/-) mice have enhanced papilloma formation, suggesting that IL-13 may be involved. Indeed, IL-13(-/-) mice developed more papillomas after exposure to DMBA/TPA than their heterozygous IL-13-competent littermate controls. However, when tested in a full carcinogenesis experiment, exposure of mice to 25 ?g of MCA, both IL-13(-/-) and IL-13(+/-) mice led to the same incidence of tumors. While IL-4 enhances MCA carcinogenesis, it does not play a measurable role in our DMBA/TPA carcinogenesis experiments. Conversely, IL-13 does not affect MCA carcinogenesis but protects mice from DMBA/TPA carcinogenesis. One possible explanation is that IL-4 and IL-13, although they share a common IL-4R? chain, regulate signaling in target cells differently by employing distinct JAK/STAT-mediated signaling pathways downstream of IL-13 or IL-4 receptor complexes, resulting in different inflammatory transcriptional programs. Taken together, our results indicate that the course of DMBA/TPA- and MCA-induced carcinogenesis is affected differently by IL-4 versus IL-13-mediated inflammatory cascades. PMID:24403255

Rothe, Michael; Quarcoo, David; Chashchina, Anna A; Bozrova, Svetlana V; Qin, Zhihai; Nedospasov, Sergei A; Blankenstein, Thomas; Kammertoens, Thomas; Drutskaya, Marina S

2013-12-01

326

IL-15.IL-15R? complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells  

PubMed Central

Interleukin (IL)-15 and its specific receptor chain, IL-15R?, support the development of various effector cells, including NK and CD8 T cells via a mechanism called trans-presentation. Whereas the dynamic of trans-presentation has been shown to involve the recycling of IL-15R? by presenting cells, the way responding cells integrate, or take advantage of this process has not been evaluated yet. To address this question, we set up a trans-presentation model using a membrane-bound IL-15.IL-15R? fusion protein, and found that IL-15 is detectable within responding cells following IL-15 trans-presentation. The role of the proteolytic cleavage of IL-15R? in this process was investigated by generating an uncleavable form of IL-15R?. We showed that IL-15 entry into responding cells necessitates the cleavage of IL-15.IL-15R? complex from the surface of IL-15 presenting cells, and observed that IL-15R? cleavage is associated with a decrease of the duration of Stat5 signaling. Once separated from presenting cells, responding cells are able to recycle IL-15.IL-15R? complexes via intracellular compartments, for residual proliferation in a time-limited manner. These studies define an unprecedented cytokine pathway in which the IL-15.IL-15R? complex cleaved from presenting cells allows responding cells to internalize, store and use IL-15.IL-15R? complex for their own proliferation and survival. PMID:24912180

Tamzalit, Fella; Barbieux, Isabelle; Plet, Ariane; Heim, Julie; Nedellec, Steven; Morisseau, Sbastien; Jacques, Yannick; Mortier, Erwan

2014-01-01

327

IL-6, IL-10 and IL-13 are associated with pathogenesis in children with Enterovirus 71 infection  

PubMed Central

In the present study, the aim was to reveal the relationship of serum IL-6, IL-10 and IL-13 levels in patient with Enterovirus 71 (EV71) infection. To elucidate the role of immune mechanisms in the pathogenesis of Hand, foot, and mouth disease (HFMD), we analyzed the cytokine of 112 EV71-infected patients. A significant elevation of serum (interleukin) IL-6, IL-10 and IL-13 levels in patients with EV71 infection compare with Un-EV71 infection HFMD patient and Healthy individuals. The production of inflammatory cytokines was increased with disease clinical stage. In addition, the immunological consequences of these cytokine in patient with EV71 infection showed a downward trend after cure. These data suggested that EV71 infection significantly increased the release of circulating IL-6, IL-10 and IL-13. The systemic inflammatory response may play an important role in the pathogenesis of HFMD. Moreover, this study may be designed to evaluate the potential therapeutic of medicine in the treatment of patients with EV71 infection. PMID:25356130

Chen, Zhifeng; Li, Ruiqin; Xie, Zhichao; Huang, Guoqiang; Yuan, Qingchun; Zeng, Jincheng

2014-01-01

328

Pupils and Parks: Environmental Education in National Parks of Developing Countries.  

ERIC Educational Resources Information Center

Describes two conservation education programs that target local primary schools and use national parks in Malaysian Borneo (Kinabalu Park) and central Brazil (Morro do Diabo Park). Both were designed using a comprehensive systems evaluation model and both resulted in cognitive and affective gains for students. (LB)

Jacobson, Susan K.; Padua, Suzana M.

1992-01-01

329

Isle Royale National Park Bibliography of Publications 1 Isle Royale National Park  

E-print Network

Isle Royale National Park Bibliography of Publications 1 Isle Royale National Park Bibliography of Publications From National Park Service NatureBib Abrams, T. 1931. Mapping Isle Royale by air. Magazine. 1909. An ecological survey of Isle Royale, Lake Superior. Wynkoop Hallenbeck Crawford Co (state

330

East Tennessee Technology Park 3-1 3. East Tennessee Technology Park  

E-print Network

East Tennessee Technology Park 3-1 3. East Tennessee Technology Park The ETTP was originally built to environmental management and restoration operations, and the name was changed to the East Tennessee Technology, the K-25 Site was named the "East Tennessee Technology Park" to reflect its new mission

Pennycook, Steve

331

INEEL Vadose Zone Research Park  

NASA Astrophysics Data System (ADS)

The Vadose Zone Research Park was developed to address mission critical issues related to operations, waste management, and environmental restoration at U. S. Department of Energy (DOE) sites that are located over thick vadose zones. The research park provides instrumentation and facilities for scientists to address vadose zone processes that are important in assessing operational activities, remedial measures, and long-term stewardship of DOE lands. The park, at the Idaho National Engineering and Environmental Laboratory (INEEL), is strategically located along the Big Lost River, an intermittent river, and around two new percolation ponds. This location provides the opportunity to study variable recharge from the river, continuous recharge from the ponds, and the interactions between the two sources. Drilling began in September 2000 and was completed in June 2001. Thirty one wells and instrumented boreholes have been installed at the park to monitor perched water, measure moisture movement, collect water and gas samples, and study intra-well geophysical properties. Nine of the boreholes, ranging in depth from 150 ft to 504 ft below land surface (bls), are instrumented to monitor moisture in the vadose zone. Instruments include: tensiometers, moisture content sensors, suction lysimeters, temperature sensors, gas ports and electrodes for electrical resistance tomography. Electrodes are evenly spaced throughout the borehole with hydrologic instruments concentrated in and near the sedimentary interbeds-discontinuous layers of silts and clays that occur between some basalt flows. Eighteen monitoring wells, ranging in depth from 60 ft to 250 ft bls, are completed with 4 or 6 inch PVC casing, and generally include an electrical resistivity electrode array attached to the casing. Three bore holes are constructed for testing cross-hole ground penetrating radar as well as for testing new nuclear logging tools being designed at the INEEL. The remaining borehole contains only an electrical resistivity electrode array. Moisture potential, temperature, and water level data are collected automatically by data loggers and transmitted by radio to a computer linked to the INEEL network. Researchers can view the data via the computer network. We are initiating studies of in-situ moisture content - matric potential curves, relative migration rates of sodium and chloride, development of preferred flow paths through the vadose zone, and imaging of background moisture movement using electrical resistivity tomography. Data collection, processing and imagery will all be automated. Imaging of all data types will be draped over the geology for correlation purposes.

Heath, G.; Hull, L.; Ansley, S.; Versteeg, R.; Scott, C.; Street, L.

2003-12-01

332

Amphibians of Olympic National Park  

USGS Publications Warehouse

Amphibians evolved from fishes about 360 million years ago and were the first vertebrates adapted to life on land. The word amphibian means "double life." It refers to the life history of many amphibians, which spend part of their life in water and part on land. There are three major groups of amphibians: salamanders, frogs, and toads, and caecilians. Salamanders, frogs, and toads can be found in Olympic National Park (ONP), but caecilians live only in tropical regions. Many amphibians are generalist predators, eating almost any prey they can fit into their mouths.

U.S. Geological Survey

2000-01-01

333

IL-27 Limits Central Nervous System Viral Clearance by Promoting IL-10 and Enhances Demyelination  

PubMed Central

IL-27 is a pleiotropic member of the IL-6 and IL-12 cytokine family composed of the IL-27p28 and the EBV-induced gene 3. IL-27 and its receptor mRNA are both upregulated in the CNS during acute encephalomyelitis induced by the JHM strain of mouse hepatitis virus (JHMV) and sustained during viral persistence. Contributions of IL-27 to viral pathogenesis were evaluated by infection of IL-27R?-chaindeficient (IL-27R??/?) mice. The absence of IL-27 signaling accelerated virus control within the CNS associated with increased IFN-? secreting virus-specific CD4+ and CD8+ T cells. Abrogation of IL-27 signaling did not affect virus-specific CD8+ T cellmediated IL-10 production or cytolytic activity or Foxp3+ regulatory T cell populations. However, IL-10 production by virus-specific CD4+ T cells was reduced significantly. Despite increased T cellmediated antiviral function in IL-27R??/? mice, the virus persisted in the CNS at similar levels as in wild-type mice. Nevertheless, IL-27R??/? mice exhibited decreased clinical disease during persistence, coincident with less severe demyelination, the hallmark tissue damage associated with JHMV infection. Overall, these data demonstrate that in contrast to viral infections at other sites, IL-27 does not play a proinflammatory role during JHMV-induced encephalomyelitis. Rather, it limits CNS inflammation and impairs control of CNS virus replication via induction of IL-10 in virus-specific CD4+ T cells. Furthermore, in contrast to its protective role in limiting CNS autoimmunity and preventing immunopathology, these data define a detrimental role of IL-27 in promoting demyelination by delaying viral control. PMID:24890725

de Aquino, Maria Teresa P.; Kapil, Parul; Hinton, David R.; Phares, Timothy W.; Puntambekar, Shweta S.; Savarin, Carine; Bergmann, Cornelia C.

2014-01-01

334

The role of genetic variation across IL-1?, IL-2, IL-6, and BDNF in antipsychotic-induced weight gain.  

PubMed

Abstract Objectives. Antipsychotics with high weight gain-inducing propensities influence the expression of immune and neurotrophin genes, which have been independently related to obesity indices. Thus, we investigated whether variants in the genes encoding interleukin (IL)-1?, IL-2, and IL-6 and brain-derived neurotrophic factor (BDNF) Val66Met are associated with antipsychotic-induced weight gain (AIWG). Methods. Nineteen polymorphisms were genotyped using Taqman() assays in 188 schizophrenia patients on antipsychotic treatment for up to 14 weeks. Mean weight change (%) from baseline was compared across genotypic groups using analysis of covariance (ANCOVA). Epistatic effects between cytokine polymorphisms and BDNF Val66Met were tested using Model-Based Multifactor Dimensionality Reduction. Results. In European patients, IL-1? rs16944*GA (P = 0.013, Pcorrected = 0.182), IL-1? rs1143634*G (P = 0.001, Pcorrected = 0.014), and BDNF Val66Met (Val/Val, P = 0.004, Pcorrected = 0.056) were associated with greater AIWG, as were IL-1? rs4849127*A (P = 0.049, Pcorrected = 0.784), and IL-1? rs16944*GA (P = 0.012, Pcorrected = 0.192) in African Americans. BDNF Val66Met interacted with both IL-1? rs13032029 (Val/Met+ TT, PPerm = 0.029), and IL-6 rs2069837 (Val/Val+ AA, PPerm = 0.021) in Europeans, in addition to IL-1? rs16944 (Val/Val+ GA, PPerm = 0.006) in African Americans. Conclusions. SNPs across IL-1? and BDNF Val66Met may influence AIWG. Replication of these findings in larger, independent samples is warranted. PMID:25560300

Fonseka, Trehani M; Tiwari, Arun K; Gonalves, Vanessa F; Lieberman, Jeffrey A; Meltzer, Herbert Y; Goldstein, Benjamin I; Kennedy, James L; Kennedy, Sidney H; Mller, Daniel J

2015-01-01

335

IL-1? Inhibits Human Osteoblast Migration  

PubMed Central

Bone has a high capacity for self-renewal and repair. Prolonged local secretion of interleukin 1? (IL-1?), however, is known to be associated with severe bone loss and delayed fracture healing. Since induction of bone resorption by IL-1? may not sufficiently explain these pathologic processes, we investigated, in vitro, if and how IL-1? affects migration of multipotent mesenchymal stromal cells (MSC) or osteoblasts. We found that homogenous exposure to IL-1? significantly diminished both nondirectional migration and site-directed migration toward the chemotactic factors platelet-derived growth factor (PDGF)-BB and insulinlike growth factor 1 (IGF-1) in osteoblasts. Exposure to a concentration gradient of IL-1? induced an even stronger inhibition of migration and completely abolished the migratory response of osteoblasts toward PDGF-BB, IGF-1, vascular endothelial growth factor A (VEGF-A) and the complement factor C5a. IL-1? induced extracellular signal-regulated kinases 1 and 2 (ERK1/2) and c-Jun N-terminal kinases (JNK) activation and inhibition of these signaling pathways suggested an involvement in the IL-1? effects on osteoblast migration. In contrast, basal migration of MSC and their migratory activity toward PDGF-BB was found to be unaffected by IL-1?. These results indicate that the presence of IL-1? leads to impaired recruitment of osteoblasts which might influence early stages of fracture healing and could have pathological relevance for bone remodeling in inflammatory bone disease. PMID:23508571

Hengartner, Nina-Emily; Fiedler, Jrg; Ignatius, Anita; Brenner, Rolf E

2013-01-01

336

Rural Latino youth park use: characteristics, park amenities, and physical activity.  

PubMed

Less than half of youth engage in sufficient physical activity to achieve health benefits. Key environmental factors of park and recreation spaces may influence youth physical activity. We sought to ascertain youth characteristics and behaviors that attract youth to parks with specific amenities and encourage physical activity while at the parks in a rural, predominantly Latino community. We examined the quality of amenities in the 13 parks and recreation spaces that middle school aged youth have access to in their community using the Environmental Assessment of Parks and Recreation Spaces (EAPRS) tool. Middle school students completed surveys in the school classroom (n = 1,102) regarding park use, physical activity, and intrapersonal characteristics (e.g., motivators). We used logistic regression to identify correlates of any park use, use of higher quality field and court parks, and active and sedentary park use. Younger age, participation in an after school activity, and identification of a team as a motivator were positively associated with any park use. Use of higher quality court and field parks was associated with participation in an after school activity and being Latino. The odds of being active in the parks were greater for boys and Latinos. Older age and alcohol use are correlated with being sedentary at the park, while odds of being sedentary at the park were lower for boys and youth who met physical activity guidelines. Organized team activities may encourage active use of higher quality fields and courts parks by Latino youth; thereby, increasing their level of physical activity. PMID:20924779

Perry, Cynthia K; Saelens, Brain E; Thompson, Beti

2011-06-01

337

115. Doughton Park Recreation Area. View of roadway alignment around ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

115. Doughton Park Recreation Area. View of roadway alignment around alligator back and parking overlook in foreground. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

338

UMore Park Sand and Gravel Resources Project University of Minnesota  

E-print Network

UMore Park Sand and Gravel Resources Project University of Minnesota Public Comment Forum and Open ­ Steven Lott, Co-project manager, UMore Park Sand and Gravel Resources Project 6:40 The UMore Park Sand

Netoff, Theoden

339

FACING NORTH ALONG CANDLER PARK DRIVE TOWARD NORTHWEST CORNER OF ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FACING NORTH ALONG CANDLER PARK DRIVE TOWARD NORTHWEST CORNER OF PARK - Candler Park Historic District, Roughly bounded by Moreland, Dekalb, McLendon & Harold Avenues, Matthews Street & Clifton Terrace, Atlanta, Fulton County, GA

340

FACING NORTH ALONG CANDLER PARK DRIVE (WESTERN BOUNDARY OF CANDLER ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FACING NORTH ALONG CANDLER PARK DRIVE (WESTERN BOUNDARY OF CANDLER PARK IS RIGHT SIDE OF ROAD IN PHOTOGRAPH) - Candler Park Historic District, Roughly bounded by Moreland, Dekalb, McLendon & Harold Avenues, Matthews Street & Clifton Terrace, Atlanta, Fulton County, GA

341

IL-1 and IL-23 Mediate Early IL-17A Production in Pulmonary Inflammation Leading to Late Fibrosis  

E-print Network

Background: Idiopathic pulmonary fibrosis is a devastating as yet untreatable disease. We demonstrated interests exist. * E-mail: couillin@cnrs-orleans.fr Introduction Idiopathic pulmonary fibrosis (IPFIL-1 and IL-23 Mediate Early IL-17A Production in Pulmonary Inflammation Leading to Late Fibrosis

Paris-Sud XI, Université de

342

Inhibition of Keratinocyte Differentiation by the Synergistic Effect of IL-17A, IL-22, IL-1?, TNF? and Oncostatin M  

PubMed Central

Keratinocyte differentiation program leading to an organized epidermis plays a key role in maintaining the first line of defense of the skin. Epidermal integrity is regulated by a tight communication between keratinocytes and leucocytes, particularly under cytokine control. Imbalance of the cytokine network leads to inflammatory diseases such as psoriasis. Our attempt to model skin inflammation showed that the combination of IL-17A, IL-22, IL-1?, OSM and TNF? (Mix M5) synergistically increases chemokine and antimicrobial-peptide expression, recapitulating some features of psoriasis. Other characteristics of psoriasis are acanthosis and down-regulation of keratinocyte differentiation markers. Our aim was to characterize the specific roles of these cytokines on keratinocyte differentiation, and to compare with psoriatic lesion features. All cytokines decrease keratinocyte differentiation markers, but IL-22 and OSM were the most powerful, and the M5 strongly synergized the effects. In addition, IL-22 and OSM induced epidermal hyperplasia in vitro and M5 induced epidermal thickening and decreased differentiation marker expression in a mouse model, as observed in human psoriatic skin lesions. This study highlights the precise role of cytokines in the skin inflammatory response. IL-22 and OSM more specifically drive epidermal hyperplasia and differentiation loss while IL-1?, IL-17A and TNF? were more involved in the activation of innate immunity. PMID:25010647

Rabeony, Hanitriniaina; Petit-Paris, Isabelle; Garnier, Julien; Barrault, Christine; Pedretti, Nathalie; Guilloteau, Karline; Jegou, Jean-Franois; Guillet, Grard; Huguier, Vincent; Lecron, Jean-Claude; Bernard, Franois-Xavier; Morel, Franck

2014-01-01

343

Clinical Significance of IL-23 Regulating IL-17A and/or IL-17F Positive Th17 Cells in Chronic Periodontitis  

PubMed Central

Objective. To investigate the expression level and clinical significance of (IL-17A+ and/or IL-17F+) Th17 cells under IL-23 regulation in patients of chronic periodontitis (CP) and healthy controls (HC). Materials and Methods. The whole peripheral blood samples were collected from 30 CP patients and 25 healthy controls. Flow cytometry was used to test the (IL-17A+ and/or IL-17F+) Th17 expression level. Recombinant human IL-23 (rhIL-23) was used to detect Th17 differentiation and expansion. Correlation coefficient analysis between Th17 expression level and clinical parameters was analyzed by SPSS software. Results. Flow cytometry results showed that IL-17A+IL-17F? and IL-17A?IL-17F+ Th17 were both increased in CP group than in HC group (P < 0.01), while, under recombinant human IL-23 (rhIL-23) stimulation, the number of IL-17A+IL-17F? Th17 cells was significantly increased in both CP and HC groups (P < 0.01). Interestingly, IL-17A?IL-17F+ Th17 cells were only increased in CP group after rhIL-23 stimulation. Additionally, correlation coefficient analysis showed significant correlation between IL-17A+IL-17F? Th17 cell and attachment loss or probing depth (P < 0.05). Conclusions. This study indicates that both the IL-17A+IL-17F? and IL-17A?IL-17F+ Th17 cells may be involved in pathogenesis of periodontitis. The role of these Th17 cells in the disease pathogenesis needs to be further investigated. PMID:25525302

Luo, Zhenhua; Wang, Hui; Wu, Yunlong; Sun, Zheng; Wu, Yafei

2014-01-01

344

Inhibition of IL6+IL6 soluble receptor-stimulated aromatase activity by the IL6 antagonist, Sant 7, in breast tissue-derived fibroblasts  

Microsoft Academic Search

Interleukin 6 (IL-6) and its soluble receptor (IL-6sR) can markedly stimulate aromatase activity in cultured fibroblasts derived from normal or malignant breast tissues. IL-6 acts by binding to a low-affinity membrane-spanning receptor (IL-6R), which must associate with a high-affinity receptor (gp130) for signal transduction to occur. Sant 7 is a mutated form of IL-6 that can bind to the IL-6R,

A Purohit; A Singh; M W Ghilchik; O Serlupi-Crescenzi; M J Reed

2003-01-01

345

?2Adrenergic receptor stimulation inhibits LPS-induced IL18 and IL12 production in monocytes  

Microsoft Academic Search

We examined the effects of ?2-adrenergic receptor (?2-AR) agonists on monocyte-derived cytokines, interleukin (IL)-18 and IL-12 production in lipopolysaccharide (LPS)-stimulated monocytes derived from human peripheral blood mononuclear cells (PBMCs), as in vitro model of sepsis. The study found that ?2-AR agonists inhibited IL-18 and IL-12 production in monocytes, and that AR agonist activity was antagonized by the selective ?2-AR antagonist,

Kenji Mizuno; Hideo Kohka Takahashi; Hiromi Iwagaki; Goutaro Katsuno; Huda A. S. M. Kamurul; Satoru Ohtani; Shuji Mori; Tadashi Yoshino; Masahiro Nishibori; Noriaki Tanaka

2005-01-01

346

Image guided thermal ablation of tumors increases the plasma level of IL-6 and IL-10  

PubMed Central

PURPOSE To identify changes in plasma cytokine levels following image-guided thermal ablation of human tumors and to identify the factors that independently predict changes in plasma cytokine levels. MATERIALS AND METHODS Whole blood samples were collected from 36 patients at 3 time points: pre-ablation, post-ablation (within 48 hours), and in follow-up (15 weeks after ablation). Plasma levels of IL-1a, IL-2, IL-6, IL-10 and TNFa were measured using a multiplex immunoassay. Univariate and multivariate analyses were performed using cytokine level as the dependent variable and sample collection, time, age, sex, primary diagnosis, metastatic status, ablation site, and ablation type as the independent variables. RESULTS There was a significant increase in the plasma level of IL-6 post-ablation when compared to pre-ablation (9.6+/?31 fold, p<0.002). IL-10 also showed a significant increase postablation (1.9 +/?2.8 fold, p<0.02). Plasma levels of IL-1a, IL-2, and TNFa were not significantly changed after ablation. Cryoablation resulted in the largest change in IL-6 level (>54 fold), while radiofrequency and microwave ablation showed 3.6 and 3.4-fold changes, respectively. Ablation of melanomas showed the largest change in IL-6 48 hours after ablation (92), followed by ablation of kidney (26), liver (8), and lung (6) cancers. Multivariate analysis revealed that ablation type (p<0.0003), and primary diagnosis (p<0.03) were independent predictors of changes to IL-6 following ablation. Age was the only independent predictor of IL-10 levels following ablation (p<0.019). CONCLUSION Image guided thermal ablation of tumors increases the plasma level of IL-6 and IL-10, without increasing the plasma level of IL-1a, IL-2, or TNFa. PMID:23582441

Erinjeri, Joseph P; Thomas, Contessa T; Samoila, Alaiksandra; Fleisher, Martin; Gonen, Mithat; Sofocleous, Constantinos T.; Thornton, Raymond H; Siegelbaum, Robert H.; Covey, Anne M.; Brody, Lynn A.; Alago, William; Maybody, Majid; Brown, Karen T.; Getrajdman, George; Solomon, Stephen B.

2014-01-01

347

PUBLIC CAR PARKS Social Sciences P1  

E-print Network

South Car Park P5 East Car Park P6 Botanic Gardens P7 Registration Center P8 Dental School P9 Mitchell PCeS Botanical Gardens 23 Terry and Lawrence Bessner Building for Zoological Research 10 Jack Green Building LAw Trubowicz Building of Law 34 W.A. Minkoff Building of Law 48 medICIne Maurice and Gabriela

Einat, Aharonov

348

Proposed Parking Changes June 1, 2010  

E-print Network

and patching of parking facilities), Electricity for headbolts, and off-campus lease costs for some parking. This would change a meter violation to $25.00 from the current $20.00. A violation for blocking a walkway or stairway would change from the current $30 to $35. Vehicle Immobilization (Boot Fee) Increase from

Wagner, Diane

349

University of Maryland College Park Physics Department  

E-print Network

University of Maryland­ College Park Physics Department Physics Summer Girls Program Application Mail to: Bernie Kozlowski 1120 Physics Building University of Maryland College Park, MD 20742 NAME why you are interested in the summer physics program at the University of Maryland. NO APPLICATION

Lathrop, Daniel P.

350

Parks, Buffer Zones, and Costly Enforcement  

Microsoft Academic Search

The reality of protected area management is that enforcing forest and park boundaries is costly and so most likely incomplete, due in part to the pressures exerted on the boundaries by local people who often have traditionally relied on the park resources. Buffer zones are increasingly being proposed and implemented to protect both forest resources and livelihoods. Developing a spatially-explicit

Elizabeth J. Z. Robinson; Heidi J. Albers

2006-01-01

351

Geology Fieldnotes: Rocky Mountain National Park, Colorado  

NSDL National Science Digital Library

In addition to offering visitor information, photographs, and links, this site traces the geologic history of this park to its beginnings as sedimentary rocks 1-2 billion years ago (Precambrian). It covers episodes of mountain building and erosion, the presence of dinosaurs and volcanoes, and glaciation, ending with the park's present geological state.

352

Measurement Properties of a Park Use Questionnaire  

PubMed Central

We determined the criterion validity and test-retest reliability of a brief park use questionnaire. From five US locations, 232 adults completed a brief survey four times and wore a global positioning system (GPS) monitor for three weeks. We assessed validity for park visits during the past week and during a usual week by examining agreement between frequency and duration of park visits reported in the questionnaire to the GPS monitor results. Spearman correlation coefficients (SCC) were used to measure agreement. For past week park visit frequency and duration, the SCC were 0.620.65 and 0.620.67, respectively. For usual week park visit frequency and duration, the SCC were 0.400.50 and 0.500.53, respectively. Usual park visit frequency reliability was 0.780.88 (percent agreement 69%82%) and usual park visit duration was 0.750.84 (percent agreement 64%73%). These results suggest that the questionnaire to assess usual and past week park use had acceptable validity and reliability. PMID:23853386

Evenson, Kelly R.; Wen, Fang; Golinelli, Daniela; Rodrguez, Daniel A.; Cohen, Deborah A.

2012-01-01

353

Geology Fieldnotes: Keweenaw National Historic Park, Michigan  

NSDL National Science Digital Library

This National Park Service site provides geological history, visitor information, maps, and selected links for further details. This park is located on the Keweenaw Peninsula on Lake Superior in Michigan, situated on a 1.1 billion year old (Precambrian) continental rift. The history is traced back to the days of copper mining by the Calumet and Hecla Mining Company.

354

Discovery Park Impact Network for Photovoltaic Technology  

E-print Network

Discovery Park Impact Network for Photovoltaic Technology NEED Discovery Park provides for Photovoltaic Technology (NPT). The NPT is designed to be a unique venue for industry-directed, university aims to become an international center of gravity for photovoltaic research that connects islands

Holland, Jeffrey

355

Big Bend National Park Virtual Field Trip  

NSDL National Science Digital Library

Big Bend National Park Virtual Field Trip is a guide to the features and geological history of the Big Bend National Park area through the Paleozoic, Mesozoic, and Cenozoic eras. The site explains igneous (intrusive, extrusive, and pyroclastic), sedimentary (erosional and depositional), metamorphic and structural processes. There is also a virtual hike of the Lost Mine Trail.

Neal, Cain; Neal, Leslie

356

The Arrest Records of Rosa Parks.  

ERIC Educational Resources Information Center

Provides background information on the arrest of Rosa Parks and the effects this event had on the Civil Rights Movement. Offers a collection of teaching activities in which the students examine the arrest records of Rosa Parks and explains that these activities are designed to accompany a unit on racial segregation. (CMK)

Bredhoff, Stacey; Schamel, Wynell; Potter, Lee Ann

1999-01-01

357

PARKING MANAGEMENT STRATEGIES FOR REDUCING AUTOMOBILE EMISSIONS  

EPA Science Inventory

This report defines the concept of parking management and explores how parking management can be used to improve air quality, support mass transit, reduce energy consumption and improve the amenities of life in urban areas. Specific aspects of this analysis were developments of a...

358

Jackson Park Hospital Green Building Medical Center  

Microsoft Academic Search

Jackson Park Hospital completed the construction of a new Medical Office Building on its campus this spring. The new building construction has adopted the City of Chicago's recent focus on protecting the environment, and conserving energy and resources, with the introduction of green building codes. Located in a poor, inner city neighborhood on the South side of Chicago, Jackson Park

William Dorsey; Nelson Vasquez

2010-01-01

359

Asulkan Valley Avalanche Track, Glacier National Park  

E-print Network

Asulkan Valley Avalanche Track, Glacier National Park Penelope Simpson, Jessica Paramio Maciej with the use of these trails ranges from bear encounters to triggering an avalanche. As in many mountainous regions, a high avalanche risk exists in the park during the winter due to the steep, rugged terrain

Smith, Dan

360

Design of Parking Lots and Garages.  

ERIC Educational Resources Information Center

Layout, control, and sign posting in the design of parking facilities is discussed emphasizing self parking and automated control. Considerations such as site, traffic, function of the facility, city codes, and sizes are related to design considerations. Traffic control factors are related to the direction and placement of cars and the collection

McConochie, William R.

361

1Nanomaterials for Energy Group Byungwoo Park  

E-print Network

-Dot- and Dye- Sensitized Solar Cells DSSC SONY DSSC KIST #12;5Nanomaterials for Energy Group e-e- h' for DSSC J-V Curve C. Nahm, H. Choi, J. Kim, S. Byun, S. Kang, T. Hwang, H. H. Park, J. Ko, and B. Park

Cho, Jaephil

362

Directions & Parking for Calit2 Building at  

E-print Network

the toll road begins) and turn left onto Bison. Turn right onto East Peltason. Turn left at Anteater Drive into Anteater Parking Structure. Exit structure by foot to East Peltason and follow pedestrian signs to Calit2 East Peltason. Turn right at Anteater Drive into Anteater Parking Structure. Exit structure by foot

George, Steven C.

363

Yellowstone National Park Region Seismicity Maps  

NSDL National Science Digital Library

This University of Utah website provides numerous maps of the Yellowstone National Park area that show the location and magnitude of historical earthquakes. Time intervals include the previous day, week, 30-days, 90-days, year, 1973 to present, 1973-1981, and 1983 to present. The maps also include latitude and longitude, park boundary, and fault information.

Stations, University O.

364

Wetland Resources of Yellowstone National Park  

NSDL National Science Digital Library

This Yellowstone National Park online report provides an overview of the park's wetlands and associated flora and fauna. Chapters include wetland plants, wetlands and wildlife, wetlands and people, thermal wetlands, a wetland inventory, wetland classification and acreage, and others. Information is presented as text, photos, graphs, tables, and maps.

Elliott Charles

365

IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells.  

PubMed

Interleukin 4 (IL-4) can suppress delayed-type hypersensitivity reactions (DTHRs), including organ-specific autoimmune diseases in mice and humans. Despite the broadly documented antiinflammatory effect of IL-4, the underlying mode of action remains incompletely understood, as IL-4 also promotes IL-12 production by dendritic cells (DCs) and IFN-?-producing TH1 cells in vivo. Studying the impact of IL-4 on the polarization of human and mouse DCs, we found that IL-4 exerts opposing effects on the production of either IL-12 or IL-23. While promoting IL-12-producing capacity of DCs, IL-4 completely abrogates IL-23. Bone marrow chimeras proved that IL-4-mediated suppression of DTHRs relies on the signal transducer and activator of transcription 6 (STAT6)-dependent abrogation of IL-23 in antigen-presenting cells. Moreover, IL-4 therapy attenuated DTHRs by STAT6- and activating transcription factor 3 (ATF3)-dependent suppression of the IL-23/TH17 responses despite simultaneous enhancement of IL-12/TH1 responses. As IL-4 therapy also improves psoriasis in humans and suppresses IL-23/TH17 responses without blocking IL-12/TH1, selective IL-4-mediated IL-23/TH17 silencing is promising as treatment against harmful inflammation, while sparing the IL-12-dependent TH1 responses. PMID:25646481

Guenova, Emmanuella; Skabytska, Yuliya; Hoetzenecker, Wolfram; Weindl, Gnther; Sauer, Karin; Tham, Manuela; Kim, Kyu-Won; Park, Ji-Hyeon; Seo, Ji Hae; Ignatova, Desislava; Cozzio, Antonio; Levesque, Mitchell P; Volz, Thomas; Kberle, Martin; Kaesler, Susanne; Thomas, Peter; Mailhammer, Reinhard; Ghoreschi, Kamran; Schkel, Knut; Amarov, Boyko; Eichner, Martin; Schaller, Martin; Clark, Rachael A; Rcken, Martin; Biedermann, Tilo

2015-02-17

366

The Parkes Observatory Pulsar Data Archive  

NASA Astrophysics Data System (ADS)

The Parkes pulsar data archive currently provides access to 144044 data files obtained from observations carried out at the Parkes observatory since the year 1991. Around 105 files are from surveys of the sky, the remainder are observations of 775 individual pulsars and their corresponding calibration signals. Survey observations are included from the Parkes 70cm and the Swinburne Intermediate Latitude surveys. Individual pulsar observations are included from young pulsar timing projects, the Parkes Pulsar Timing Array and from the PULSE@Parkes outreach program. The data files and access methods are compatible with Virtual Observatory protocols. This paper describes the data currently stored in the archive and presents ways in which these data can be searched and downloaded.

Hobbs, G.; Miller, D.; Manchester, R. N.; Dempsey, J.; Chapman, J. M.; Khoo, J.; Applegate, J.; Bailes, M.; Bhat, N. D. R.; Bridle, R.; Borg, A.; Brown, A.; Burnett, C.; Camilo, F.; Cattalini, C.; Chaudhary, A.; Chen, R.; D'Amico, N.; Kedziora-Chudczer, L.; Cornwell, T.; George, R.; Hampson, G.; Hepburn, M.; Jameson, A.; Keith, M.; Kelly, T.; Kosmynin, A.; Lenc, E.; Lorimer, D.; Love, C.; Lyne, A.; McIntyre, V.; Morrissey, J.; Pienaar, M.; Reynolds, J.; Ryder, G.; Sarkissian, J.; Stevenson, A.; Treloar, A.; van Straten, W.; Whiting, M.; Wilson, G.

2011-08-01

367

Geologic Heritage in the National Parks  

NSDL National Science Digital Library

What is geologic heritage, you ask? In short, it "encompasses the significant geologic features, landforms, and landscapes characteristic of our Nation." The National Park Service has a special program to document these sites and to provide the public with resources about these unique destinations. The materials here are divided into four featured programs: Fossil Resources, Geologic Heritage Conservation, Park Geology Tour, and Cave and Karst Resources. Using the Park Geology Tour, visitors can search through thematic areas such as glaciers, fossils, and plate tectonics to find highlights from a vast array of National Park units. The Cave and Karst Resources program brings together resources on some of the over 4,900 caves in the National Park system, along with detailed photo galleries, newsletters, and brochures. Finally, under Fossil Resources visitors can find information about National Fossil Day and even helpful lesson plans for teachers.

2013-03-22

368

Evaluation of serum concentrations of interleukin (IL)-4, IL-10, and IL-12 during pregnancy in bitches.  

PubMed

Complex cytokine networks play an important role in a wide range of pregnancy-related processes. During physiological pregnancy, the balance of T helper lymphocytes Th1 and Th2 is strongly shifted toward Th2, which has a protective role in the feto-maternal interaction. The aim of the present study is to establish the serum concentrations, ranges, and trends of anti-inflammatory interleukin (IL)-4 and IL-10, and inflammatory IL-12A, during three phases of gestation in the bitch (20-30, 31-40, and 41-57 days of gestation). Our results indicate that, in early gestation, IL-4 and -10 serum concentrations are elevated and might depend on progesterone that could act as a potent inhibitor of Th1 responses inducing, conversely, the production of Th2-type cytokines (i.e., IL-10 and IL-4). On the other hand, between 30 and 40 days of gestation, the concentrations of the anti-inflammatory ILs decrease probably because of high concentrations of prolactin, which is endowed with immunostimulatory properties on different immune cell types. In the third phase of gestation (41-57 days), an increase in IL-10 occurs, which might depend on high levels of 17?-estradiol that, during pregnancy, interfere with the ability of dendritic cells to stimulate T lymphocytes, acting as an anti-inflammatory factor. Conversely, the low and persistent concentrations of inflammatory IL-12A, throughout pregnancy, compared with anti-inflammatory ILs, might depend on the characteristic cytokine products of Thl and Th2 cells that are known to be mutually inhibitory. The monitoring of immunological status via the levels of cytokines during pregnancy in the bitch, could represent a diagnostic tool to predict and/or prevent pregnancy abnormality, as demonstrated in women. PMID:23422356

Pantaleo, M; Piccinno, M; Roncetti, M; Mutinati, M; Rizzo, A; Sciorsci, R L

2013-04-01

369

Distribution of the IL-1RN, IL-6, IL-10, INF-?, and TNF-? Gene Polymorphisms in the Mexican Population  

PubMed Central

Background: Cytokines are a group of polypeptides with an important role in the inflammatory response. It has been suggested that certain polymorphisms located in several cytokine genes are associated with different diseases. The aim of the present study was to establish the gene frequency of 13 polymorphisms of the IL-1RN, IL-6, IL-10, INF-?, and TNF-? genes in a Mexican population. These polymorphisms have been reported in several populations, with important variation in frequency according to the studied population. Methods: Thirteen polymorphisms (rs419598, rs315951, rs2234663, rs3811058, rs1800796, rs2069827, rs1800896, rs1800871, rs1800872, rs1800629, rs2069709, rs2069710, and rs361525) were analyzed by 5? exonuclease TaqMan genotyping assays in a group of 248 healthy unrelated Mexican individuals. Results: The results obtained showed that the studied Mexican population presents significant differences (p<0.05) in the distribution of the IL1RN (rs419598, rs315951, and and rs2234663), IL1F10 (rs3811058), IL6 (rs1800796, rs2069827), IL10 (rs1800896, rs1800871, and rs1800872), and TNF-? (rs1800629) polymorphisms when compared to Caucasian, Asian, and African populations. Conclusions: In summary, the distribution of the IL-1RN, IL-6, IL-10, and TNF-? cytokine gene polymorphisms distinguishes the studied Mexican population from other groups. Since the alleles of these cytokines are associated with the development of several inflammatory diseases, knowledge of the distribution of these alleles in the studied Mexican population could be helpful to understand their true role as a genetic susceptibility marker in this population. PMID:22971140

Vargas-Alarcon, Gilberto; Ramrez-Bello, Julin; Jurez-Cedillo, Teresa; Ramrez-Fuentes, Silvestre; Carrillo-Snchez, Silvia

2012-01-01

370

Role of IL-12p40 in cervical carcinoma  

PubMed Central

Background: Previously, we have shown that low IL-12p40 mRNA expression by cervical cancer cells is associated with a poor survival of cervical cancer patients. As IL-12p40 is both a subcomponent of interleukin (IL)-12 and IL-23, the aim of this study was to elucidate the role of IL-12p40 in cervical cancer. Methods: We have measured the expression of IL-23p19 mRNA, IL-12p35 mRNA and IL-12p40 mRNA using mRNA in situ hybridisation. The IL-1 and IL-6 were measured by immunohistochemistry. Results: As IL-23 is a component of the IL-17/IL-23 pathway, a pathway induced by IL-1 and IL-6 in humans, we have studied IL-1 and IL-6 expression. Only a high number of stromal IL-6-positive cells was shown to associate with poor disease-specific survival. The worst disease-specific survival was associated with a subgroup of patients that displayed a high number of IL-6-positive cells and low IL-12p40 expression (P<0.001). Both a high number of IL-6-positive cells and a high number of IL-6-positive cells, plus low IL-12p40 expression were shown to be clinicopathological parameters independent of lymph node metastasis, parametrial involvement and Sedlis score (P=0.009 and P=0.007, respectively). Conclusion: Our results with IL-6 and IL-12p40 are in accordance with the hypothesis that the IL-17/IL-23 pathway has a suppressive role in cervical cancer. PMID:23099807

Zijlmans, H J M A A; Punt, S; Fleuren, G J; Trimbos, J B; Kenter, G G; Gorter, A

2012-01-01

371

IL-1 Blockade in Autoinflammatory Syndromes1  

PubMed Central

Monogenic autoinflammatory syndromes present with excessive systemic inflammation including fever, rashes, arthritis, and organ-specific inflammation and are caused by defects in single genes encoding proteins that regulate innate inflammatory pathways. Pathogenic variants in two interleukin-1 (IL-1)regulating genes, NLRP3 and IL1RN, cause two severe and early-onset autoinflammatory syndromes, CAPS (cryopyrin associated periodic syndromes) and DIRA (deficiency of IL-1 receptor antagonist). The discovery of the mutations that cause CAPS and DIRA led to clinical and basic research that uncovered the key role of IL-1 in an extended spectrum of immune dysregulatory conditions. NLRP3 encodes cryopyrin, an intracellular molecular sensor that forms a multimolecular platform, the NLRP3 inflammasome, which links danger recognition to the activation of the proinflammatory cytokine IL-1?. The success and safety profile of drugs targeting IL-1 in the treatment of CAPS and DIRA have encouraged their wider use in other autoinflammatory syndromes including the classic hereditary periodic fever syndromes (familial Mediterranean fever, TNF receptorassociated periodic syndrome, and hyperimmunoglobulinemia D with periodic fever syndrome) and additional immune dysregulatory conditions that are not genetically well defined, including Stills, Behcets, and Schnitzler diseases. The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1?-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease. PMID:24422572

Jesus, Adriana A.; Goldbach-Mansky, Raphaela

2014-01-01

372

Correlation between serum levels of IL-15 and IL-17 in patients with idiopathic inflammatory myopathies.  

PubMed

Objectives: To assess the serum levels of interleukin (IL)-15 and IL-17 in patients with idiopathic inflammatory myopathies (IIM) and correlate them with levels of IL-1 receptor antagonist (IL-1ra), IL-6, IL-10, interferon (IFN)-?, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1?, and MIP-1?. Possible correlations with disease activity parameters were also evaluated. Method: Sera from 14 patients with new-onset polymyositis (PM), 10 with dermatomyositis (DM), seven with anti-synthetase syndrome (ASS) and 19 healthy controls (HC) were analysed by multiplex immunoassay. Sera from 19 patients were analysed after a median follow-up of 5 months. All patients underwent physical examination, manual muscle testing (MMT) using the five-point MMT scales, the Health Assessment Questionnaire (HAQ), and serum creatine kinase (CK) measurement. All patients received glucocorticoids, and 13 were taking immunosuppressive therapy. Results: At baseline, serum levels of IL-15, IL-17, MCP-1, and MIP-1? were significantly higher in IIM patients than in HC. IL-17 serum levels were directly correlated (r = 0.39, p = 0.02) with disease duration while a significant inverse correlation was detected between IL-17 levels and MMT scores (r = -0.4, p = 0.02). The highest IL-15 levels were present in DM patients (p = 0.02 vs. PM). The most striking finding was the strong correlation between IL-15 and IL-17 levels (r = 0.60, p = 0.0001), and this correlation was even stronger in DM patients (r = 0.82, p = 0.006). Conclusions: The strong correlation between IL-15 and IL-17 in IIM patients, and especially in DM, suggests that there may be an interplay between the two cytokines in the pathogenesis of myositis. Further studies of larger patient cohorts and of muscle biopsies are needed to confirm these preliminary data. PMID:25379698

Notarnicola, A; Lapadula, G; Natuzzi, D; Lundberg, Ie; Iannone, F

2014-11-01

373

Expression of IL-18, IL-18 Binding Protein, and IL-18 Receptor by Normal and Cancerous Human Ovarian Tissues: Possible Implication of IL-18 in the Pathogenesis of Ovarian Carcinoma  

PubMed Central

Proinflammatory cytokine IL-18 has been shown to be elevated in the sera of ovarian carcinoma patients. The aim of the study was to examine the levels and cellular origin of IL-18, IL-18 binding protein, and IL-18 receptor in normal and cancerous ovarian tissues. Ovarian tissue samples were examined by immunohistochemical staining for IL-18, IL-18BP, and IL-18R and mRNA of these cytokines was analyzed with semiquantitative PT-PCR. IL-18 levels were significantly higher in cancerous ovarian tissues (P = 0.0007), IL-18BP levels were significantly higher in normal ovarian tissues (P = 0.04), and the ratio of IL-18/IL-18BP was significantly higher in cancerous ovarian tissues (P = 0.036). Cancerous ovarian tissues expressed significantly higher IL-18 mRNA levels (P = 0.025), while there was no difference in the expression of IL-18BP mRNA and IL-18R mRNA between cancerous and normal ovarian tissues. IL-18 and IL-18BP were expressed dominantly in the epithelial cells of both cancerous and normal ovarian tissues, while IL-18R was expressed dominantly in the epithelial cells of cancerous ovarian tissues but expressed similarly in the epithelial and stromal cells of normal cancerous tissues. This study indicates a possible role of IL-18, IL-18BP, and IL-18R in the pathogenesis of epithelial ovarian carcinoma. PMID:24963217

Medina, Liat; Rabinovich, Alex; Piura, Benjamin; Dyomin, Victor; Shaco Levy, Ruthy; Huleihel, Mahmoud

2014-01-01

374

Happy Hollow Park and Zoo  

NSDL National Science Digital Library

The Happy Hollow Park and Zoo participates in conservation and propagation of rare and endangered species by providing hands-on experience with many animals along with the education that's necessary to secure the future of endangered species. The Zoo is in partnership with a number of organizations, including the Belize Audubon Society, the Bushmeat Crisis Task Force, the Center for Ecosystem Survival, the Orangutan Conservancy, and the Ngamba Island Chimpanzee Sanctuary, to help educate the public and raise funds to protect endangered species. The interactive exhibit, Backyard Habitat, was constructed in partnership with Watershed Watch by the Happy Hollow staff using conservation grant dollars. It provides visitors with ideas on how they might turn their own backyard into wildlife habitats. Guests may also obtain a handy pamphlet at this exhibit, Invite Wildlife Into Your Backyard. Educational programs also include Pre-K classes, teacher/classroom programs, camps, Scouts programs and Zoofaris guided tours.

375

Saltfjellet-Svartisen Park, Norway  

NASA Technical Reports Server (NTRS)

The Arctic Circle cuts through the western coast of Norway and the Saltfjellet-Svartisen National Park. This area features many glacial fjords, alpine mountain formations with glacier tongues, as well as gently sloping mountain plateaus and forested lowland valleys. The largest city here is Mo I Rana, (just off the image to the east) with a population of 25,000 (26th most populous city in Norway). Once supported entirely by the town's steel mill, the area has developed into a tourist center.

The image covers an area of 51 x 57 km, was acquired on August 23, 2006, and is located near 66.6 degrees north latitude, 13 degrees east longitude.

The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate.

2007-01-01

376

MHC class I and TCR avidity control the CD8 T cell response to IL-15/IL-15R? complex.  

PubMed

IL-15 operates via a unique mechanism termed transpresentation. In this system, IL-15 produced by one cell type is bound to IL-15R? expressed by the same cell and is presented to apposing cells expressing the IL-15R?/?C complex. We have shown that administering soluble IL-15R? complexed with IL-15 can greatly enhance IL-15 activity. We now show that the naive CD8 T cell response to exogenous IL-15/IL-15R? complex is MHC class I dependent. In the absence of ?2 microglobulin, naive CD8 T cells scarcely proliferated in response to IL-15/IL-15R? complex, whereas memory cells proliferated, although to a lesser extent, compared with levels in control mice. The loss of ?2m or FcRn slightly reduced the extended half-life of IL-15/IL-15R? complex, whereas FcRn deficiency only partially reduced the naive CD8 T cell proliferative response to IL-15/IL-15R? complex. In addition, we demonstrated a link between TCR avidity and the ability of a T cell to respond to IL-15/IL-15R? complex. Thus, T cells expressing low-avidity TCR responded poorly to IL-15/IL-15R? complex, which correlated with a poor homeostatic proliferative response to lymphopenia. The inclusion of cognate peptide along with complex resulted in enhanced proliferation, even when TCR avidity was low. IL-15/IL-15R? complex treatment, along with peptide immunization, also enhanced activation and the migratory ability of responding T cells. These data suggest that IL-15/IL-15R? complex has selective effects on Ag-activated CD8 T cells. Our findings have important implications for directing IL-15/IL-15R? complex-based therapy to specific Ag targets and illustrate the possible adjuvant uses of IL-15/IL-15R? complex. PMID:21041729

Stoklasek, Thomas A; Colpitts, Sara L; Smilowitz, Henry M; Lefranois, Leo

2010-12-01

377

Comparison of in vivo effects of human recombinant IL 1 and human recombinant IL 6 in mice.  

PubMed

IL 1 and IL 6 share a number of biological activities, including induction of fever, neutrophilia and acute phase response, and IL 1 induces IL 6 production by fibroblasts and macrophages. Therefore, it was proposed that IL 6 mediates many of the activities of IL 1. To test this hypothesis in vivo, we assessed induction of IL 6 following IL 1 alpha administration to mice and tested IL 6 for radioprotection and induction of early (CSF) and late (fibrinogen and SAA) acute phase reactants. IL 1 alpha given to mice ip induced, in a dose dependent manner, detectable IL 6 in circulation, with maximal titers at 2-4 hrs. However, unlike IL 1 which is 10-1000 ng/mouse of human recombinant IL 6 did not result in increased survival of mice following lethal irradiation. In fact, such treatment given 20 hrs before LD50/30 doses of radiation resulted in reduced survival of mice. However, IL 6 augmented the radioprotective effect of IL 1. IL 1 in doses above 10 ng/mouse induced within 2 to 6 hrs a dose dependent increase in CSF in circulation, but IL 6 did not induce detectable levels of CSF at 2, 6 and 20 hrs after administration. Administration of IL 6 to mice produced a dose dependent increase in circulating fibrinogen and SAA. Similarly, administration of IL 1 resulted in much greater increases in levels of fibrinogen and SAA. Therefore, IL 1 is a more effective inducer of fibrinogen and SAA in mice than is IL 6. Although definitive conclusions concerning the relative roles for IL 1 and IL 6 in vivo will await availability of anti IL 1 and anti-IL 6 antibodies, our data do not support the suggestion that the above IL 1 effects can be attributed solely to IL 6. PMID:3145371

Neta, R; Vogel, S N; Sipe, J D; Wong, G G; Nordan, R P

1988-01-01

378

Hepatitis C virus induces interleukin-1? (IL-1?)/IL-18 in circulatory and resident liver macrophages.  

PubMed

Hepatitis C virus (HCV)-mediated chronic liver disease is a global health problem, and inflammation is believed to be an important player in disease pathogenesis. HCV infection often leads to severe fibrosis/cirrhosis and hepatocellular carcinoma, although the mechanisms for advancement of disease are not fully understood. The proinflammatory cytokines interleukin-1? (IL-1?) and IL-18 have critical roles in establishment of inflammation. In this study, we examined induction of IL-1?/IL-18 secretion following HCV infection. Our results demonstrated that monocyte-derived human macrophages (THP-1) incubated with cell culture-grown HCV enhance the secretion of IL-1?/IL-18 into culture supernatants. A similar cytokine release was also observed for peripheral blood mononuclear cell (PBMC)-derived primary human macrophages and Kupffer cells (liver-resident macrophages) upon incubation with HCV. THP-1 cells incubated with HCV led to caspase-1 activation and release of proinflammatory cytokines. Subsequent studies demonstrated that HCV induces pro-IL-1? and pro-IL-18 synthesis via the NF-?B signaling pathway in macrophages. Furthermore, introduction of HCV viroporin p7 RNA into THP-1 cells was sufficient to cause IL-1? secretion. Together, our results suggested that human macrophages exposed to HCV induce IL-1? and IL-18 secretion, which may play a role in hepatic inflammation. PMID:24006444

Shrivastava, Shubham; Mukherjee, Anupam; Ray, Ranjit; Ray, Ratna B

2013-11-01

379

IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival.  

PubMed

Natural killer T (NKT) cells are innate-like T cells that rapidly recognize pathogens and produce cytokines that shape the ensuing immune response. IL-17-producing NKT cells are enriched in barrier tissues, such as the lung, skin, and peripheral lymph nodes, and the factors that maintain this population in the periphery have not been elucidated. Here we show that NKT17 cells deviate from other NKT cells in their survival requirements. In contrast to conventional NKT cells that are maintained by IL-15, ROR?t(+) NKT cells are IL-15 independent and instead rely completely on IL-7. IL-7 initiates a T-cell receptor-independent (TCR-independent) expansion of NKT17 cells, thus supporting their homeostasis. Without IL-7, survival is dramatically impaired, yet residual cells remain lineage committed with no downregulation of ROR?t evident. Their preferential response to IL-7 does not reflect enhanced signaling through STAT proteins, but instead is modulated via the PI3K/AKT/mTOR signaling pathway. The ability to compete for IL-7 is dependent on high-density IL-7 receptor expression, which would promote uptake of low levels of IL-7 produced in the non-lymphoid sites of lung and skin. This dependence on IL-7 is also reported for ROR?t(+) innate lymphoid cells and CD4(+) Th17 cells, and suggests common survival requirements for functionally similar cells. PMID:24448098

Webster, K E; Kim, H-O; Kyparissoudis, K; Corpuz, T M; Pinget, G V; Uldrich, A P; Brink, R; Belz, G T; Cho, J-H; Godfrey, D I; Sprent, J

2014-09-01

380

Development of regulatory T cells requires IL-7R? stimulation by IL-7 or TSLP  

PubMed Central

Interleukin-7 (IL-7), a cytokine produced by stromal cells, is required for thymic development and peripheral homeostasis of most major subsets of T cells. We examined whether regulatory T (Treg) cells also required the IL-7 pathway by analyzing IL-7R??/? mice. We observed a striking reduction in cells with the Treg surface phenotype (CD4, CD25, GITR (glucocorticoid-induced tumor necrosis factor [TNF]-like receptor), CD45RB, CD62L, CD103) or intracellular markers (cytotoxic T-lymphocyteassociated antigen-4, CTLA-4, and forkhead box transcription factor 3, Foxp3). Foxp3 transcripts were virtually absent in IL-7R??/? lymphoid tissues, and no Treg cell suppressive activity could be detected. There are 2 known ligands for IL-7R?: IL-7 itself and thymic stromal lymphopoietin (TSLP). Surprisingly, mice deficient in IL-7 or the other chain of the TSLP receptor (TSLPR) developed relatively normal numbers of Treg cells. Combined deletion of IL-7 and TSLP receptor greatly reduced Treg cell development in the thymus but was not required for survival of mature peripheral Treg cells. We conclude that Treg cells, like other T cells, require signals from the IL-7 receptor, but unlike other T cells, do not require IL-7 itself because of at least partially overlapping actions of IL-7 and TSLP for development of Treg cells. PMID:18664628

Mazzucchelli, Renata; Hixon, Julie A.; Spolski, Rosanne; Chen, Xin; Li, Wen Qing; Hall, Veronica L.; Willette-Brown, Jami; Hurwitz, Arthur A.; Leonard, Warren J.

2008-01-01

381

A natural experiment to examine the impact of park renewal on park-use and park-based physical activity in a disadvantaged neighbourhood: the REVAMP study methods  

PubMed Central

Background Modifying the built environment by improving parks is potentially a sustainable way to increase population level physical activity. Despite considerable investment in parks and park renovations, few natural experiments on the impact of improving amenities on park use and park-based physical activity have been conducted. REVAMP is a natural experiment that aims to examine whether park improvement increases overall park usage, park-based physical activity and active travel to and from the park in the intervention compared with the control park over a two-year period; and to identify which specific aspects of the park refurbishment attracts park visitors and encourages park users to be more active. This paper describes the methods of the REVAMP study. Methods The intervention park is a large regional park (329 hectares) located in a low socio-economic status (SES) area in the north-eastern suburbs of Melbourne, Australia. The control park is a regional park (120 hectares) located in a high SES area in the eastern suburbs of Melbourne. Multiple methodologies to evaluate the impact of the park renovation are being employed including: cross-sectional surveys of local residents living near the two parks, direct observations of park users, intercept surveys with park users, and electronic monitoring of path usage and car traffic within the parks. Baseline measures were conducted in April-May 2013 (T1), and an innovative play space suitable for children of all ages and abilities was installed at the intervention park between September 2013 and February 2014. Follow-up measures will be repeated in April-May 2014 (T2) and April-May 2015 (T3). All methodologies will be completed at both the intervention and control parks at all three time-points, with the exception of the cross-sectional survey of local residents which will only be conducted at T1 and T3. Conclusion This research will inform future park developments, and will contribute to creating an evidence base of the impact of park refurbishment, and the development of natural experiment methodology. Trial Registration Current controlled trial ISRCTN50745547, registration date 11.1.2014. PMID:24924919

2014-01-01

382

SH2-containing protein tyrosine phosphatase 1 is required for IL4-induced IL4R expression in spleen cells  

Microsoft Academic Search

To investigate the role of SH-2-containing protein tyrosine phosphatase 1, SHP-1, in IL-4-induced IL-4 receptor (IL-4R) expression,\\u000a we examined IL-4 receptor ?-chain (IL-4R?) mRNA expression in Na3VO4-treated wild type (WT) spleen cells and measured IL-4R mRNA in IL-4-stimulated spleen cells of viable motheaten mice (me\\u000a v\\/mev). It is found that IL-4-induced IL-4R mRNA expression was impaired in Na3VO4-treated WT spleen

Xin Cao; Zan Huang; Jingyi Fan

2005-01-01

383

Circulating IL-15 exists as heterodimeric complex with soluble IL-15R? in human and mouse serum  

PubMed Central

IL-15 is an important cytokine for the function of the immune system, but the form(s) of IL-15 produced in the human body are not fully characterized. Coexpression of the single-chain IL-15 and the IL-15 receptor alpha (IL-15R?) in the same cell allows for efficient production, surface display, and eventual cleavage and secretion of the bioactive IL-15/IL-15R? heterodimer in vivo, whereas the single-chain IL-15 is poorly secreted and unstable. This observation led to the hypothesis that IL-15 is produced and secreted only as a heterodimer with IL-15R?. We purified human IL-15/IL-15R? complexes from overproducing human cell lines and developed an ELISA specifically measuring the heterodimeric form of IL-15. Analysis of sera from melanoma patients after lymphodepletion revealed the presence of circulating IL-15/IL-15R? complexes in amounts similar to the total IL-15 quantified by a commercial IL-15 ELISA that detects both the single-chain and the heterodimeric forms of the cytokine. Therefore, in lymphodepleted cancer patients, the serum IL-15 is exclusively present in its heterodimeric form. Analysis of the form of IL-15 present in either normal or lymphodepleted mice agrees with the human data. These results have important implications for development of assays and materials for clinical applications of IL-15. PMID:22496150

Bear, Jenifer; Rosati, Margherita; Beach, Rachel Kelly; Alicea, Candido; Sowder, Raymond; Chertova, Elena; Rosenberg, Steven A.; Felber, Barbara K.

2012-01-01

384

RESISTANCE TO INTESTINAL COCCIDIOSIS FOLLOWING DNA IMMUNIZATION WITH THE CLONED 3-1E EIMERIA GENE PLUS IL-2, IL-15, AND IFN-GAMMA  

Technology Transfer Automated Retrieval System (TEKTRAN)

A cloned Eimeria acervulina gene (3-1E) was used to vaccinate chickens in ovo against coccidiosis both alone and in combination with genes encoding IL-1, IL-2, IL-6, IL-8, IL-15, IL-16, IL-17, IL-18, or IFN-gamma. Vaccination efficacy was assessed by increased serum anti-3-1E antibody titers, reduc...

385

Geology Fieldnotes: Yosemite National Park, California  

NSDL National Science Digital Library

This National Park Service (NPS) site details Yosemite National Park in California with information such as geology, photographs, links to maps and other facts, and visitor information. Yosemite's landscape is shaped by alpine glaciation landforms such as moraines, plucking, scouring, and U-shaped valleys. Part of the Sierra Nevada mountain range, formation of the area began 500 million years ago (Cambrian). This site details the geologic history of the park up to the present time with continued evolution through weathering and erosion. Also discussed are the wilderness and vegetation (sub-alpine and Sequoia groves).

386

Geology of Death Valley National Park  

NSDL National Science Digital Library

This site of the United States Geologic Survey (USGS) and the National Park Service (NPS) highlights the geologic history of Death Valley National Park in Nevada and California. The story begins 1.8 billion years ago with the formation of rocks and continues through uplift, faulting, volcanism, early animals of the area, glaciers, and the making of deserts and dunes. A geologic timescale connects to specific events in the history of Death Valley. There are topographic maps of the area, a field trip of the park, an image gallery, and technical papers available to download.

387

The quandary of local peoplePark relations in Nepal's Royal Chitwan National Park  

NASA Astrophysics Data System (ADS)

This paper analyzes five major causes of park-people conflicts that have occurred in Nepal's Royal Chitwan National Park. The causes include illegal transactions of forest products from the park, livestock grazing in the park, illegal hunting and fishing, crop damage, and threats to human and animal life caused by wild animals from the park. The conflicts indicate a reciprocal relationship between the park and local people. They reflect the attitudes of local people and representatives of the park authority whose priorities and objectives largely diverge. The results show that people settled adjacent to the park are heavily dependent on its resources. Even in places where some, albeit few alternative sources exist, local people continue to trespass the park boundary as these sources are inadequate to ensure the fulfillment of local people's resource needs. Illegal transactions of resources continue throughout the year; however, they are less intense during summer due to flooding caused by the Rapti River, which forms the park boundary towards the northern section where this study is conducted. The frequency of local people's visits to the park is mainly determined by their age, distance between homesteads and park, and volume of crop loss caused by wild animals. Crop damage is the function of size of landholding, distance, and frequency of crop raid. Local people claim that they have no intention of letting their livestock graze in the park; however, the dense vegetation of the park attracts livestock grazing on riverbanks just outside the open park boundary. Many head of livestock are killed by carnivores of the park. Human casualties are mainly caused by sloth bear ( Melursus ursinus), tiger ( Panthera tigris), wild pig ( Sug scrofa), and rhinoceros ( Rhinoceros unicornis). There had been some earlier attempts to reconcile the conflicts by offering local people different kinds of compensations; however, these were unsuccessful measures. An integrated approach is essential if efforts to resolve the park-people conflicts are to succeed. The government is in the process of launching a project that aims to resolve the inherent problems with such an approach. Suggestions are made to incorporate some key elements, such as maintaining effective communication between various parties and the potential for wildlife conservation among local people.

Nepal, Sanjay K.; Weber, Karl E.

1995-11-01

388

Kineret/IL-1ra Blocks the IL-1/IL-8 Inflammatory Cascade during Recombinant Panton Valentine Leukocidin-Triggered Pneumonia but Not during S. aureus Infection  

PubMed Central

Objectives Community-acquired Staphylococcus aureus necrotizing pneumonia is a life-threatening disease. Panton Valentine Leukocidin (PVL) has been associated with necrotizing pneumonia. PVL triggers inflammasome activation in human macrophages leading to IL-1? release. IL-1? activates lung epithelial cells to release IL-8. This study aimed to assess the relevance of this inflammatory cascade in vivo and to test the potential of an IL-1 receptor antagonist (IL-1Ra/Kineret) to decrease inflammation-mediated lung injury. Methods We used the sequential instillation of Heat-killed S. aureus and PVL or S. aureus infection to trigger necrotizing pneumonia in rabbits. In these models, we investigated inflammation in the presence or absence of IL-1Ra/Kineret. Results We demonstrated that the presence of PVL was associated with IL-1? and IL-8 release in the lung. During PVL-mediated sterile pneumonia, Kineret/IL-1Ra reduced IL-8 production indicating the relevance of the PVL/IL-1/IL-8 cascade in vivo and the potential of Kineret/IL-1Ra to reduce lung inflammation. However, Kineret/IL-1Ra was ineffective in blocking IL-8 production during infection with S. aureus. Furthermore, treatment with Kineret increased the bacterial burden in the lung. Conclusions Our data demonstrate PVL-dependent inflammasome activation during S.aureus pneumonia, indicate that IL-1 signaling controls bacterial burden in the lung and suggest that therapy aimed at targeting this pathway might be deleterious during pneumonia. PMID:24905099

Hayez, Davy; Da Silva, Sonia; Badiou, Cdric; Couzon, Florence; Bes, Michle; Chavanet, Pascal; Lina, Grard; Vandenesch, Franois; Croisier-Bertin, Delphine; Henry, Thomas

2014-01-01

389

Repeated administration of IL-31 upregulates IL-31 receptor A (IL-31RA) in dorsal root ganglia and causes severe itch-associated scratching behaviour in mice.  

PubMed

We investigated the effects of repeated administration of interleukin-31 (IL-31) on itch-associated scratching counts (long-lasting scratching, LLS) and IL-31-related receptor mRNA expression in mice. Intra-dermal (i.d.) injection of IL-31 (100 and 300ng/site) every 12h for 3days significantly increased LLS. Repeated administration of IL-31 also increased the expression of IL-31 receptor A (IL-31RA) and oncostatin M receptor beta (OSMR?) in dorsal root ganglia (DRG). After the repeated administration of IL-31 was discontinued, IL-31RA expression decreased and reached the baseline level 2days after the last dose of IL-31. LLS changed along with DRG IL-31RA expression. Moreover, IL-31-induced IL-31RA protein expression was confirmed by Western blotting analysis. These data suggest that IL-31 upregulates IL-31RA expression in DRG neuron cell bodies, and cutaneous-injected IL-31-induced itching is enhanced by DRG IL-31RA expression in mice. PMID:25381841

Arai, Iwao; Tsuji, Minoru; Miyagawa, Kazuya; Takeda, Hiroshi; Akiyama, Nobutake; Saito, Saburo

2015-01-01

390

A second-order time-accurate ALE LagrangeGalerkin method applied to wind engineering and control of bridge profiles  

Microsoft Academic Search

In this paper, we propose a second-order time-accurate ALE formulation of LagrangeGalerkin methods for the transient solution of NavierStokes equations for an incompressible fluid in a moving domain. Following a previous work [Rev. Europenne lm. Finis 8 (1999) 659], we show that this time discretization, based on a backward differentiation formula and the construction of characteristic paths in a grid-relative

Gilles Fourestey; Serge Piperno

2004-01-01

391

Formulation of 36-noded piezoelectric spectral finite element scheme with active/passive layers coupled by Lagrange multipliers  

NASA Astrophysics Data System (ADS)

A novel spectral finite element formulation scheme is presented for modeling a plate structure with surface-mounted piezoelectric transducers. Surface-mounted piezoelectric transducers may asymmetrically distribute the mass in the thickness direction of the plate/panel structure, resulting in a coupled mass matrix in spectral element formulation. A new procedure is developed by equating the layer-wise kinematics of the element using undetermined Lagrange multipliers to achieve the diagonal mass matrix. To demonstrate the effectiveness of the element formulation scheme, a two-dimensional piezoelectric spectral element is constructed with 36 nodes and five active/passive layers (layers: transducer/bond/plate/bond/transducer). The performance of the developed element is illustrated by (a) simulation of Lamb wave propagation and estimation of its velocity, and (b) simulation of the effect of transducer size, its dynamics and shear lag on sensors response. The results presented highlight the importance of modeling the dynamics of transducers and understanding the effects on sensor response. The presented technique has relevance in the field of structural health monitoring, wherein it can be used to model and simulate aircraft panels with surface-mounted piezoelectric transducers.

Ashwin, U.; Raja, S.; Sathyanarayana, C. N.

2014-08-01

392

Numerical Analysis of the Dynamics of Two- and Three-Dimensional Fluidized Bed Reactors using an Euler-Lagrange Approach  

SciTech Connect

Biomass thermochemical conversion, often done in fluidized beds, recently gained a lot of attention due to its potential to efficiently produce renewable liquid fuels. Optimization of reactor design and operating conditions, however, requires a fundamental understanding of bed dynamics. In this work, a numerical framework based on an Euler-Lagrange approach is developed and used to perform and analyze large-scale simulations of two- and three-dimensional periodic fluidized beds. Collisions are handled using a soft-sphere model. An efficient parallel implementation allows one to explicitly track over 30 million particles, which is representative of the number of particles found in lab-scale reactor, therefore demonstrating the capability of Lagrangian approaches to simulate realistic systems at that scale. An on-the-fly bubble identification and tracking algorithm is used to characterize bubble dynamics for inlet velocities up to 9 times the minimum fluidization velocity. Statistics for gas volume fraction, gas and particle velocities, bed expansion, and bubble size and velocity, is compared across the two- and three-dimensional configurations, and comparison with literature data generally shows good agreement. The wide distribution of gas residence times observed in the simulations is linked to the different gas hold-up characteristics of the gas-solid system.

Pepiot, P.; Desjardins, O.

2012-04-01

393

International Space Station Centrifuge Rotor Models A Comparison of the Euler-Lagrange and the Bond Graph Modeling Approach  

NASA Technical Reports Server (NTRS)

The assembly and operation of the International Space Station (ISS) require extensive testing and engineering analysis to verify that the Space Station system of systems would work together without any adverse interactions. Since the dynamic behavior of an entire Space Station cannot be tested on earth, math models of the Space Station structures and mechanical systems have to be built and integrated in computer simulations and analysis tools to analyze and predict what will happen in space. The ISS Centrifuge Rotor (CR) is one of many mechanical systems that need to be modeled and analyzed to verify the ISS integrated system performance on-orbit. This study investigates using Bond Graph modeling techniques as quick and simplified ways to generate models of the ISS Centrifuge Rotor. This paper outlines the steps used to generate simple and more complex models of the CR using Bond Graph Computer Aided Modeling Program with Graphical Input (CAMP-G). Comparisons of the Bond Graph CR models with those derived from Euler-Lagrange equations in MATLAB and those developed using multibody dynamic simulation at the National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC) are presented to demonstrate the usefulness of the Bond Graph modeling approach for aeronautics and space applications.

Nguyen, Louis H.; Ramakrishnan, Jayant; Granda, Jose J.

2006-01-01

394

Rotary car park (pallet design) computer aided design analysis study  

Microsoft Academic Search

The increment of vehicle in UiTM main campus had contributed to parking problem because of limited parking space. Hence, rotary parking system could be one of alternative solution. Since it is a big system, this research focuses only on the platform (where cars will be parked on top of it) upper pallet structure. Initial design process stage [1] (conceptual, embodiement

Nursalbiah Nasir; Helmi Rashid; Abdul Halim Abdullah; Muhammad Azzeim Mat Jusoh

2011-01-01

395

36 CFR 7.2 - Crater Lake National Park.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 2010-07-01 false Crater Lake National Park. 7.2 Section 7.2...THE NATIONAL PARK SYSTEM 7.2 Crater Lake National Park. (a) Fishing. Fishing in Crater Lake and park streams is permitted from May...

2010-07-01

396

36 CFR 7.2 - Crater Lake National Park.  

Code of Federal Regulations, 2012 CFR

...2012-07-01 2012-07-01 false Crater Lake National Park. 7.2 Section 7.2...THE NATIONAL PARK SYSTEM 7.2 Crater Lake National Park. (a) Fishing. Fishing in Crater Lake and park streams is permitted from May...

2012-07-01

397

36 CFR 7.2 - Crater Lake National Park.  

...2014-07-01 2014-07-01 false Crater Lake National Park. 7.2 Section 7.2...THE NATIONAL PARK SYSTEM 7.2 Crater Lake National Park. (a) Fishing. Fishing in Crater Lake and park streams is permitted from May...

2014-07-01

398

1. AERIAL VIEW, LOOKING SOUTH, FROM PARK AND MUNICIPAL BUILDINGS, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. AERIAL VIEW, LOOKING SOUTH, FROM PARK AND MUNICIPAL BUILDINGS, ALONG 20TH STREET NORTH TOWARDS THE BIRMINGHAM CITY CENTER WITH BIRMINGHAM MUSEUM OF ART (BOTTOM LEFT), BIRMINGHAM MUNICIPAL AUDITORIUM (BOTTOM RIGHT), BIRMINGHAM CITY HALL (CENTER RIGHT), JEFFERSON COUNTY COURTHOUSE (CENTER LEFT) AND LINN PARK (CENTER) - Linn Park, Bounded by Park Place, Eighth Avenue, Short Twentieth & Twenty-first Streets, Birmingham, Jefferson County, AL

399

36 CFR 7.66 - North Cascades National Park.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false North Cascades National Park. 7.66 ...PARK SYSTEM 7.66 North Cascades National Park. (a) Bait...superintendent may designate as open to the use of snowmobiles...National Park: (1) The Cascade River Road between the...

2010-07-01

400

9. VIEW FROM MANY PARKS CURVE (ON TRAIL RIDGE ROAD) ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. VIEW FROM MANY PARKS CURVE (ON TRAIL RIDGE ROAD) OF HORSESHOE PARK, SHOWING FALL RIVER ROAD FAINTLY AT LEFT AT BASE OF SHEEP MOUNTAIN AND CROSSING ALLUVIAL FAN FROM LAWN LAKE FLOOD. - Fall River Road, Between Estes Park & Fall River Pass, Estes Park, Larimer County, CO

401

36 CFR 7.41 - Big Bend National Park.  

Code of Federal Regulations, 2010 CFR

...Property 1 2010-07-01 2010-07-01 false Big Bend National Park. 7.41 Section 7.41 Parks, Forests...REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM 7.41 Big Bend National Park. (a) Fishing; closed waters....

2010-07-01

402

36 CFR 7.7 - Rocky Mountain National Park.  

Code of Federal Regulations, 2013 CFR

...Property 1 2013-07-01 2013-07-01 false Rocky Mountain National Park. 7.7 Section 7.7 Parks, Forests...REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM 7.7 Rocky Mountain National Park. (a) Fishing. (1) Fishing...

2013-07-01

403

36 CFR 7.7 - Rocky Mountain National Park.  

Code of Federal Regulations, 2012 CFR

...Property 1 2012-07-01 2012-07-01 false Rocky Mountain National Park. 7.7 Section 7.7 Parks, Forests...REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM 7.7 Rocky Mountain National Park. (a) Fishing. (1) Fishing...

2012-07-01

404

36 CFR 7.93 - Guadalupe Mountains National Park.  

Code of Federal Regulations, 2013 CFR

... 1 2013-07-01 2013-07-01 false Guadalupe Mountains National Park. 7.93 Section 7.93 Parks, Forests...AREAS OF THE NATIONAL PARK SYSTEM 7.93 Guadalupe Mountains National Park. (a) Cave entry. No person shall...

2013-07-01

405

36 CFR 7.93 - Guadalupe Mountains National Park.  

Code of Federal Regulations, 2012 CFR

... 1 2012-07-01 2012-07-01 false Guadalupe Mountains National Park. 7.93 Section 7.93 Parks, Forests...AREAS OF THE NATIONAL PARK SYSTEM 7.93 Guadalupe Mountains National Park. (a) Cave entry. No person shall...

2012-07-01

406

36 CFR 7.93 - Guadalupe Mountains National Park.  

Code of Federal Regulations, 2010 CFR

... 1 2010-07-01 2010-07-01 false Guadalupe Mountains National Park. 7.93 Section 7.93 Parks, Forests...AREAS OF THE NATIONAL PARK SYSTEM 7.93 Guadalupe Mountains National Park. (a) Cave entry. No person shall...

2010-07-01

407

36 CFR 7.7 - Rocky Mountain National Park.  

...Property 1 2014-07-01 2014-07-01 false Rocky Mountain National Park. 7.7 Section 7.7 Parks, Forests...REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM 7.7 Rocky Mountain National Park. (a) Fishing. (1) Fishing...

2014-07-01

408

36 CFR 7.93 - Guadalupe Mountains National Park.  

... 1 2014-07-01 2014-07-01 false Guadalupe Mountains National Park. 7.93 Section 7.93 Parks, Forests...AREAS OF THE NATIONAL PARK SYSTEM 7.93 Guadalupe Mountains National Park. (a) Cave entry. No person shall...

2014-07-01

409

36 CFR 7.93 - Guadalupe Mountains National Park.  

Code of Federal Regulations, 2011 CFR

... 1 2011-07-01 2011-07-01 false Guadalupe Mountains National Park. 7.93 Section 7.93 Parks, Forests...AREAS OF THE NATIONAL PARK SYSTEM 7.93 Guadalupe Mountains National Park. (a) Cave entry. No person shall...

2011-07-01

410

Case Studies Relating to UMore Park UMore Development LLC  

E-print Network

Case Studies Relating to UMore Park UMore Development LLC 230 McNamara Alumni Center 200 Oak Street.edu #12;Case Studies: UMore Park Martin Kohn Summer 2012 2 Executive Summary In order to better understand Park (UMore Park) case studies were carried out on other successful planned communities

Netoff, Theoden

411

Building for Quality Education--The Educational Park Concept.  

ERIC Educational Resources Information Center

Speakers and discussions at this one day conference were dedicated to building for quality education, with major emphasis on the concept of educational parks. The five major speeches are--(1) Advantages and Disadvantages of Educational Parks, (2) Educational Parks: Appalachian Style, emphasizing a twist in the park idea in order to accommodate

McClurkin, W.D.

412

Induced volition: Resettlement from the Limpopo National Park, Mozambique  

Microsoft Academic Search

This paper focuses on the resettlement process taking place in the context of the creation of the Limpopo National Park in Mozambique, which is part of the Great Limpopo Transfrontier Park. About 26,000 people are currently living in the park; 7000 of whom will be resettled to an area southeast of the park. The Mozambican government and donors funding the

Jessica Milgroom; Marja Spierenburg

2008-01-01

413

IL23 Compensates for the Absence of IL12p70 and Is Essential for the IL17 Response during Tuberculosis but Is Dispensable for Protection and Antigen-Specific IFN Responses if IL12p70 Is Available1  

Microsoft Academic Search

IL-12p70 induced IFN- is required to control Mycobacterium tuberculosis growth; however, in the absence of IL-12p70, an IL-12p40-dependent pathway mediates induction of IFN- and initial bacteriostatic activity. IL-23 is an IL-12p40-dependent cytokine containing an IL-12p40 subunit covalently bound to a p19 subunit that is implicated in the induction of CD4 T cells associated with autoimmunity and inflammation. We show that

Shabaana A. Khader; John E. Pearl; Kaori Sakamoto; Leigh Gilmartin; Guy K. Bell; Dawn M. Jelley-Gibbs; Nico Ghilardi; Andrea M. Cooper

414

Rural Latino Youth Park Use: Characteristics, Park Amenities, and Physical Activity  

Microsoft Academic Search

Less than half of youth engage in sufficient physical activity to achieve health benefits. Key environmental factors of park\\u000a and recreation spaces may influence youth physical activity. We sought to ascertain youth characteristics and behaviors that\\u000a attract youth to parks with specific amenities and encourage physical activity while at the parks in a rural, predominantly\\u000a Latino community. We examined the

Cynthia K. PerryBrain; Brain E. Saelens; Beti Thompson

2011-01-01

415

IL-22 but not IL-17 provides protection to hepatocytes during acute liver inflammation  

PubMed Central

Summary The cytokine IL-22 is primarily expressed by Th17 CD4 T cells and is highly upregulated during chronic inflammatory diseases. IL-22 receptor expression is absent on immune cells, but is instead restricted to the tissues, providing signaling directionality from the immune system to the tissues. However, the role of IL-22 in inflammatory responses has been confounded by data suggesting both pro- and ant-inflammatory functions. Herein, we provide evidence that during inflammation IL-22 plays a protective role in preventing tissue injury. Hepatocytes from mice deficient in IL-22 are highly sensitive to the detrimental immune response associated with hepatitis. Additionally, IL-22 expressing Th17 cells can provide protection during hepatitis in IL-22 deficient mice. On the other hand, IL-17, which is co-expressed with IL-22 and can induce similar cellular responses, has no observable role in liver inflammation. Our data suggest that IL-22 serves as a protective molecule to counteract the destructive nature of the immune response to limit tissue damage. PMID:17919941

Zenewicz, Lauren A.; Yancopoulos, George D.; Valenzuela, David M.; Murphy, Andrew J.; Karow, Margaret; Flavell, Richard A.

2007-01-01

416

Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2.  

PubMed

T helper 17 (Th17) cells specifically transcribe the Il17 and Il17f genes, which are localized in the same chromosome region, but the underlying mechanism is unclear. Here, we report a cis element that we previously named conserved noncoding sequence 2 (CNS2) physically interacted with both Il17 and Il17f gene promoters and was sufficient for regulating their selective transcription in Th17 cells. Targeted deletion of CNS2 resulted in impaired retinoic acid-related orphan receptor gammat (ROR?t)-driven IL-17 expression in vitro. CNS2-deficient T cells also produced substantially decreased amounts of IL-17F. These cytokine defects were associated with defective chromatin remodeling in the Il17-Il17f gene locus, possibly because of effects on CNS2-mediated recruitment of histone-modifying enzymes p300 and JmjC domain-containing protein 3 (JMJD3). CNS2-deficient animals were also shown to be resistant to experimental autoimmune encephalomyelitis (EAE). Our results thus suggest that CNS2 is sufficient and necessary for Il17 and optimal Il17f gene transcription in Th17 cells. PMID:22244845

Wang, Xiaohu; Zhang, Yibing; Yang, Xuexian O; Nurieva, Roza I; Chang, Seon Hee; Ojeda, Sandra S; Kang, Hong S; Schluns, Kimberly S; Gui, Jianfang; Jetten, Anton M; Dong, Chen

2012-01-27

417

IL-1? and IL-18: inflammatory markers or mediators of hypertension?  

PubMed

Chronic inflammation in the kidneys and vascular wall is a major contributor to hypertension. However, the stimuli and cellular mechanisms responsible for such inflammatory responses remain poorly defined. Inflammasomes are crucial initiators of sterile inflammation in other diseases such as rheumatoid arthritis and gout. These pattern recognition receptors detect host-derived danger-associated molecular patterns (DAMPs), such as microcrystals and reactive oxygen species, and respond by inducing activation of caspase-1. Caspase-1 then processes the cytokines pro-IL-1? and pro-IL-18 into their active forms thus triggering inflammation. While IL-1? and IL-18 are known to be elevated in hypertensive patients, no studies have examined whether this occurs downstream of inflammasome activation or whether inhibition of inflammasome and/or IL-1?/IL-18 signalling prevents hypertension. In this review, we will discuss some known actions of IL-1? and IL-18 on leukocyte and vessel wall function that could potentially underlie a prohypertensive role for these cytokines. We will describe the major classes of inflammasome-activating DAMPs and present evidence that at least some of these are elevated in the setting of hypertension. Finally, we will provide information on drugs that are currently used to inhibit inflammasome/IL-1?/IL-18 signalling and how these might ultimately be used as therapeutic agents for the clinical management of hypertension. PMID:25117218

Krishnan, S M; Sobey, C G; Latz, E; Mansell, A; Drummond, G R

2014-12-01

418

Photodynamic therapy affects the expression of IL-6 and IL-10 in vivo  

NASA Astrophysics Data System (ADS)

Photodynamic therapy (PDT), which can effectively destroy malignant tissue, also induces a complex immune response which potentiates anti-tumor immunity, but also inhibits skin contact hypersensitivity (CHS) and prolongs skin graft survival. The underlying mechanisms responsible for these effects are poorly understood, but are likely to involve meditation by cytokines. We demonstrate in a BALB/c mouse model that PDT delivered to normal and tumor tissue in vivo causes marked changes in the expression of cytokines interleukin (IL)-6 and IL-10. IL-6 mRNA and protein are rapidly and strongly enhanced in the PDT treated EMT6 tumor. Previous studies have shown that intratumoral injection of IL- 6 or transduction of the IL-6 gene into tumor cells can enhance tumor immunogenicity and inhibit tumor growth in experimental murine tumor systems. Thus, PDT may enhance local anti-tumor immunity by up-regulating IL-6. PDT also results in an increase in IL-10 mRNA and protein in the skin. The same PDT regime which enhances IL-10 production in the skin has been shown to strongly inhibit the CHS response. The kinetics of IL-10 expression coincide with the known kinetics of PDT induced CHS suppression and we propose that the enhanced IL-10 expression plays a role in the observed suppression of cell mediated responses seen following PDT.

Gollnick, Sandra O.; Musser, David A.; Henderson, Barbara W.

1998-05-01

419

Inflammasome activation and IL-1?/IL-18 processing are influenced by distinct pathways in microglia  

PubMed Central

Microglia are important innate immune effectors against invading CNS pathogens, such as Staphylococcus aureus (S. aureus), a common etiological agent of brain abscesses typified by widespread inflammation and necrosis. The NLRP3 inflammasome is a protein complex involved in IL-1? and IL-18 processing following exposure to both pathogen- and danger-associated molecular patterns. Although previous studies from our laboratory have established that IL-1? is a major cytokine product of S. aureus-activated microglia and is pivotal for eliciting protective anti-bacterial immunity during brain abscess development, the molecular machinery responsible for cytokine release remains to be determined. Therefore, the functional role of the NLRP3 inflammasome and its adaptor protein apoptosis-associated speck-like protein (ASC) in eliciting IL-1? and IL-18 release was examined in primary microglia. Interestingly, we found that IL-1?, but not IL-18 production, was significantly attenuated in both NLRP3 and ASC knockout (KO) microglia following exposure to live S. aureus. NLRP3 inflammasome activation was partially dependent on autocrine/paracrine ATP release and ?- and ?-hemolysins produced by live bacteria. A cathepsin B inhibitor attenuated IL-? release from NLRP3 and ASC KO microglia, demonstrating the existence of alternative inflammasome-independent mechanisms for IL-1? processing. In contrast, microglial IL-18 secretion occurred independently of cathepsin B and inflammasome action. Collectively, these results demonstrate that microglial IL-1? processing is regulated by multiple pathways and diverges from mechanisms utilized for IL-18 cleavage. Understanding the molecular events that regulate IL-1? production is important for modulating this potent proinflammatory cytokine during CNS disease. PMID:21913925

Hanamsagar, Richa; Torres, Victor; Kielian, Tammy

2011-01-01

420

IL-17A Expression in HIV-Specific CD8 T Cells Is Regulated by IL-4/IL-13 Following HIV-1 Prime-Boost Immunization.  

PubMed

Although Th1 and Th2 cytokines can inhibit interleukin (IL)-17-secreting T cells, how these cells are regulated under different infectious conditions is still debated. Our previous studies have shown that vaccination of IL-4 and IL-13 gene knockout (KO) mice can induce high-avidity HIV K(d)Gag197-205-specific CD8 T cells with better protective efficacy. In this study, when IL-13, IL-4, STAT6 KO, and wild-type BALB/c mice were prime-boost immunized with an HIV poxviral modality, elevated numbers of IL-17A(+) splenic K(d)Gag197-205-specific CD8 T cells were observed in all the KO mice compared with the wt BALB/c control. Similarly, when wt BALB/c mice were immunized with IL-13R?2-adjuvanted HIV vaccines (that transiently inhibited IL-13 activity and induced high-avidity CD8 T cells with enhanced protective efficacy), elevated IL-17A(+) K(d)Gag197-205-specific CD8 T cells were detected both in the lung and the spleen. However, at the transcriptional level, elevated TGF-?, IL-6, ROR-?t, and IL-17A mRNA copy numbers were mainly detected in IL-4 KO, but not the IL-13 KO mice. These data suggested that TGF-?, IL-6, ROR-?t, but not IL-23a, played a role in IL-17A regulation in K(d)Gag197-205-specific CD8 T cells. Collectively, our findings suggest that IL-4 and IL-13 differentially regulate the expression of IL-17A in K(d)Gag197-205-specific CD8 T cells at the transcriptional and translational level, respectively, implicating IL-17A as an indirect modulator of CD8 T cell avidity and protective immunity. PMID:25493691

Ravichandran, Jayashree; Jackson, Ronald J; Trivedi, Shubhanshi; Ranasinghe, Charani

2014-12-10

421

15 CFR 265.17 - Parking permits.  

Code of Federal Regulations, 2013 CFR

...REGULATIONS GOVERNING TRAFFIC AND CONDUCT ON THE GROUNDS OF THE NATIONAL INSTITUTE OF STANDARDS & TECHNOLOGY, GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Traffic and Vehicular Regulations 265.17 Parking permits. No...

2013-01-01

422

15 CFR 265.17 - Parking permits.  

Code of Federal Regulations, 2010 CFR

...REGULATIONS GOVERNING TRAFFIC AND CONDUCT ON THE GROUNDS OF THE NATIONAL INSTITUTE OF STANDARDS & TECHNOLOGY, GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Traffic and Vehicular Regulations 265.17 Parking permits. No...

2010-01-01

423

15 CFR 265.16 - Parking.  

...REGULATIONS GOVERNING TRAFFIC AND CONDUCT ON THE GROUNDS OF THE NATIONAL INSTITUTE OF STANDARDS & TECHNOLOGY, GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Traffic and Vehicular Regulations 265.16 Parking. No person,...

2014-01-01

424

Fire Damage in Yosemite National Park  

USGS Multimedia Gallery

The sequoia forests of Yosemite National Park rely on a fire ecology-based ecosystem. Periodic forest fires clear out underbrush and shade-tolerant trees like white fir trees, allowing sequoia seedlings toreach adulthood....

425

Hidden Lake in Glacier National Park, Montana  

USGS Multimedia Gallery

Hidden Lake in Glacier National Park, Montana, USA, a high mountain lake in an alpine setting. This lake is kept full of water mainly from precipitation runoff from the surrounding hills and, in the spring, from snowmelt....

426

SECTION ELEVEN Site Design Guidelines Parking  

E-print Network

outlines loca ons for these facili es. Parking lots should be considered according to the following criteria: Their size in rela on to the facili es they serve and to site limita ons such as: available

Duchowski, Andrew T.

427

Parking & Transportation Department RESIDENT -PERSONAL INFORMATION  

E-print Network

_____________________________________________________________________________________ Please be sure to contact the Parking & Transportation Department with any changes to your information, i.e. personal or vehicle. For Office Use Only: Reg Date: ________________ Permit Issue Date

Oliver, Douglas L.

428

Urban Parks: Volunteers and Civic Engagement  

E-print Network

When citizens are engaged with urban park and recreation departments, everyone benefits. This publication describes successful programs that involve community volunteers, and explains what managers can do to engage citizens in such programs....

Schuett, Michael A.

2007-03-02

429

Occurrence of breeding bird species in urban parks: Effects of park structure and broad-scale variables  

Microsoft Academic Search

Occurrences of breeding bird species in 54 urban parks were investigated in the city of Oulu in northern Finland. Park area, human activity, habitat, and landscape structure within a 9-ha square surrounding the study park were related to the bird species richness and occurrence of individual bird species. A total of 22 species was observed. The area of the park

Jukka Jokimki

1999-01-01

430

Parking at or near Smithsonian Museums At Smithsonian museums: The Smithsonian does not operate any commercial parking facilities; however,  

E-print Network

throughout the city; time limit varies by street. A. Commercial parking companies in Washington, D commercial parking facilities; however, there are numerous commercial parking lots and garages located within.si.edu. Near Smithsonian museums: On-street parking in Washington, D.C., is limited; the use of public

Mathis, Wayne N.

431

Geology Fieldnotes: Zion National Park, Utah  

NSDL National Science Digital Library

Zion is located on the edge of the Colorado Plateau, and is part of a formation known as the Grand Staircase (Bryce Canyon and the Grand Canyon are also part of this formation). The site discusses the formation of the park, from sedimentation 240 million years ago (Triassic), to lithification, uplift, and erosion. Visible formations include the Navajo sandstone and the Kaibab formation. Additional resources include visitor information, maps, photographs, and a teacher feature (lessons for teaching geology with National Parks as examples).

Foos, Annabelle

432

Jackson Park Hospital Green Building Medical Center  

SciTech Connect

Jackson Park Hospital completed the construction of a new Medical Office Building on its campus this spring. The new building construction has adopted the City of Chicagoâ??s recent focus on protecting the environment, and conserving energy and resources, with the introduction of green building codes. Located in a poor, inner city neighborhood on the South side of Chicago, Jackson Park Hospital has chosen green building strategies to help make the area a better place to live and work.

William Dorsey; Nelson Vasquez

2010-03-01

433

Interleukin-13 (IL-13)/IL-13 Receptor ?1 (IL-13R?1) Signaling Regulates Intestinal Epithelial Cystic Fibrosis Transmembrane Conductance Regulator Channel-dependent Cl? Secretion*  

PubMed Central

Interleukin-13 (IL-13) has been linked to the pathogenesis of inflammatory diseases of the gastrointestinal tract. It is postulated that IL-13 drives inflammatory lesions through the modulation of both hematopoietic and nonhematopoietic cell function in the intestine. To delineate the relevant contribution of elevated levels of intestinal IL-13 to intestinal structure and function, we generated an intestinal IL-13 transgenic mouse (iIL-13Tg). We show that constitutive overexpression of IL-13 in the small bowel induces modification of intestinal epithelial architecture (villus blunting, goblet cell hyperplasia, and increased epithelial proliferation) and epithelial function (altered basolateral ? apical Cl? ion conductance). Pharmacological analyses in vitro and in vivo determined that elevated Cl? conductance is mediated by altered cystic fibrosis transmembrane conductance regulator expression and activity. Generation of iIL-13Tg/Il13r?1?/?, iIL-13Tg/Il13r?2?/?, and iIL-13Tg/Stat6?/? mice revealed that IL-13-mediated dysregulation of epithelial architecture and Cl? conductance is dependent on IL-13R?1 and STAT-6. These observations demonstrate a central role for the IL-13/IL-13R?1 pathway in the regulation of intestinal epithelial cell Cl? secretion via up-regulation of cystic fibrosis transmembrane conductance regulator, suggesting an important role for this pathway in secretory diarrhea. PMID:21303908

Wu, David; Ahrens, Richard; Osterfeld, Heather; Noah, Taeko K.; Groschwitz, Katherine; Foster, Paul S.; Steinbrecher, Kris A.; Rothenberg, Marc E.; Shroyer, Noah F.; Matthaei, Klaus I.; Finkelman, Fred D.; Hogan, Simon P.

2011-01-01

434

Chloride flux out of Yellowstone National Park  

USGS Publications Warehouse

Monitoring of the chloride concentration, electrical conductivity, and discharge was carried out for the four major rivers of Yellowstone National Park from September 1982 to January 1984. Chloride flux out of the Park was determined from the measured values of chloride concentration and discharge. The annual chloride flux from the Park was 5.86 ?? 1010 g. Of this amount 45% was from the Madison River drainage basin, 32% from the Yellowstone River basin, 12% from the Snake River basin, and 11% from the Falls River basin. Of the annual chloride flux from the Yellowstone River drainage basin 36% was attributed to the Yellowstone Lake drainage basin. The geothermal contribution to the chloride flux was determined by subtracting the chloride contribution from rock weathering and atmospheric precipitation and is 94% of the total chloride flux. Calculations of the geothermal chloride flux for each river are given and the implications of an additional chloride flux out of the western Park boundary discussed. An anomalous increase in chloride flux out of the Park was observed for several weeks prior to the Mt. Borah earthquake in Central Idaho on October 28, 1983, reaching a peak value shortly thereafter. It is suggested that the rise in flux was a precursor of the earthquake. The information in this paper provides baseline data against which future changes in the hydrothermal systems can be measured. It also provides measurements related to the thermal contributions from the different drainage basins of the Park. ?? 1985.

Norton, D.R.; Friedman, I.

1985-01-01

435

Acid Rain in Shenandoah National Park, Virginia  

USGS Publications Warehouse

Visitors to Shenandoah National Park (SNP) enjoy the animal and plant life and the scenery but may not realize how vulnerable these features are to various threats, such as invasion of exotic plants and insects, improper use of park resources by humans, and air and water pollution. The National Park Service strives to protect natural resources from such threats to ensure that the resources will be available for enjoyment now and in the future. Because SNP has limited influence over the air pollution that envelops the region, acidic deposition--commonly known as acid rain--is one of the more challenging threats facing park managers. With the help of U.S. Geological Survey (USGS) scientists, park managers can understand how acid rain interacts with ground- and surface-water resources, which enables them to explain why reductions in air pollution can help preserve park resources. Such understanding also provides essential insight into ecosystem processes, as managers strive to unravel and resolve other environmental problems that are interrelated to acid rain.

Rice, Karen C.; Deviney, Frank A., Jr.; Olson, Gordon

2007-01-01

436

Automated parking garage system model  

NASA Technical Reports Server (NTRS)

A one-twenty-fifth scale model of the key components of an automated parking garage system is described. The design of the model required transferring a vehicle from an entry level, vertically (+Z, -Z), to a storage location at any one of four storage positions (+X, -X, +Y, +Y, -Y) on the storage levels. There are three primary subsystems: (1) a screw jack to provide the vertical motion of the elevator, (2) a cam-driven track-switching device to provide X to Y motion, and (3) a transfer cart to provide horizontal travel and a small amount to vertical motion for transfer to the storage location. Motive power is provided by dc permanent magnet gear motors, one each for the elevator and track switching device and two for the transfer cart drive system (one driving the cart horizontally and the other providing the vertical transfer). The control system, through the use of a microprocessor, provides complete automation through a feedback system which utilizes sensing devices.

Collins, E. R., Jr.

1975-01-01

437

National Park Service: Dry Tortugas  

NSDL National Science Digital Library

The website for the Dry Tortugas, a group of seven islands 70 miles off the coast of Key West, and a National Park site, will warm visitors instantly with its photos of the blue and green waters and sun-kissed lands. The website also offers visitors lots of background on these islands that are "near-pristine natural resources including sea grass beds, fisheries, and sea turtle and bird nesting habitat." On the left hand side of the homepage are links to "History and Culture", "Photos and Multimedia", "Nature and Science", and "For Kids". The "History and Culture" section called "Places" provides the Tortugas' history as a "ship trap" with the subcategories "Windjammer Shipwreck", "Fort Jefferson" and "Lighthouses". Visitors shouldn't miss checking out the "Preservation" category, which includes "Submerged Cultural Resources". Visitors can view a short slide show of the underwater cultural treasures on which archaeological survey crews conduct condition assessments. Some of the treasures include cannons and anchors that now reside in the South Florida Collections Management Center.

438

Ionizing radiation enhances IL-6 and IL-8 production by human endothelial cells  

PubMed Central

Irradiation exposure is known to induce an inflammatory reaction. Endothelial cells play a crucial role both in the inflammatory process and in radiation damage. Therefore, supernatants and cell lysates of 60Co-irradiated human umbilical vein endothelial cells (HUVEC) have been assessed for the presence of pro-inflammatory cytokines. After gamma irradiation, interleukin (IL)-1?, IL-1? and tumor necrosis factor (TNF)-? remained undetectable in both cell supernatants and cell lysates. However, a dose-dependent increase in the production of IL-6 and IL-8 has been demonstrated up to 6 days after exposure. These data indicate that the pro-inflammatory cytokines IL-6 and IL-8 may be involved in the inflammatory response of vascular endothelium induced by exposure to ionizing radiation. PMID:18472819

Bertho, J.-M.; Vandamme, M.; Gaugler, M.-H.

1997-01-01

439

Involvement of IL-6 and IL-1 receptor antagonist on intellectual disability.  

PubMed

Imbalances in the regulation of pro-inflammatory cytokines have been increasingly correlated with several neurodevelopmental disorders and their role in neuronal development is being investigated. To assess the possible influence of cytokines on the onset of intellectual disability (ID), we studied the polymorphisms of thirteen proinflammatory cytokine genes in 81 patients and 61 healthy controls. We demonstrated a significant association of interleukin-6 (IL-6) single-nucleotide polymorphism (SNP) (-174 G/C and nt565 G/A), and interleukin-1 receptor antagonist (IL-1RA) (Mspa-I 11100) SNP with ID. Moreover, the IL-6 SNPs is an unfavorable genetic predisposition for females. The evaluation of circulating levels of IL-6 and IL-1RA showed that the serum concentrations of IL-6 were significantly higher in ID patients than in controls. These data suggest that functional cytokine gene polymorphisms may influence the development of ID. PMID:25124963

Aureli, A; Sebastiani, P; Del Beato, T; Marimpietri, A E; Graziani, A; Sechi, E; Di Loreto, S

2014-11-01

440

Expression of IL-17, IL-23 and Their Receptors in Minor Salivary Glands of Patients with Primary Sjgren's Syndrome  

PubMed Central

The main purpose of this study was to determine the expression of interleukins-17/-23 (ILs-17/-23) and receptors of interleukins-17/-23 (IL-17R, IL-23R) in minor salivary glands (MSGs) of patients with primary Sjgren's syndrome (pSS). Expression of IL-17, IL-23 and receptors of IL-17/-23 was analyzed in MSGs from 25 patients with pSS, 25 patients with probable preclinical pSS, and 25 patients with nonautoimmune sicca syndrome by immunohistochemistry. Comparison of the expression of IL-17, IL-23 and receptors of IL-17, IL-23 in MSG of patients with pSS with probable preclinical pSS, and with nonautoimmune sicca syndrome showed significant differences between three groups. However, the expression of IL-17, IL-23 and receptors of IL-17/-23 in MSG was comparable in pSS and probable preclinical pSS patients. We did not find correlation between the expression of IL-17 and IL-23 and of IL-17R and IL-23R in patients with pSS. These results demonstrate an involvement of IL-17/-23 system in the early pSS pathogenesis. PMID:22262980

Mieliauskaite, Diana; Dumalakiene, Irena; Rugiene, Rita; Mackiewicz, Zygmunt

2012-01-01

441

Severe Neutrophil-Dominated Inflammation and Enhanced Myelopoiesis in IL-33-Overexpressing CMV/IL33 Mice.  

PubMed

IL-33 is a cytokine of the IL-1 family, which signals through the ST2 receptor. Previous studies emphasized a role for IL-33 in shaping innate and adaptive immune responses. IL-33 was also reported to modulate myelopoiesis and myeloid cell activity. In this article, we describe IL-33-overexpressing CMV/IL33 and LysM/IL33 mice, which display an inflammatory phenotype associated with growth retardation and paw swelling. The phenotype of CMV/IL33 mice is dependent on activation of the ST2 receptor and is characterized by extensive neutrophil infiltration into different organs, including the paws. Local or systemic levels of proinflammatory mediators such as IL-1?, Cxcl-1, G-CSF, and IL-6 are increased. CMV/IL-33 mice also suffer from anemia, thrombocytosis, and a marked dysregulation of myelopoiesis, leading to an important increase in myeloid cell production or accumulation in bone marrow (BM), spleen, and peripheral blood. Consistently, recombinant IL-33 induced proliferation of myeloid lineage cells in BM-derived granulocyte cultures, whereas IL-33 knockout mice exhibited minor deficiencies in spleen and BM myeloid cell populations. Our observations reveal a neutrophil-dominated inflammatory phenotype in IL-33-overexpressing CMV/IL33 and LysM/IL33 mice, and highlight important regulatory effects of IL-33 on myelopoiesis in vitro and in vivo, where excessive IL-33 signaling can translate into the occurrence of a myeloproliferative disorder. PMID:25505285

Talabot-Ayer, Dominique; Martin, Praxedis; Vesin, Christian; Seemayer, Christian Alexander; Vigne, Solenne; Gabay, Cem; Palmer, Gaby

2015-01-15

442

Fine mapping and trans-ethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21  

PubMed Central

Objective Genetic association of the IL2/IL21 region at 4q27 has been previously reported in lupus and a number of autoimmune and inflammatory diseases. Herein, using a very large cohort of lupus patients and controls, we localize this genetic effect to the IL21 gene. Methods We genotyped 45 tag SNPs across the IL2/IL21 locus in two large independent lupus sample sets. We studied a European-derived set consisting of 4,248 lupus patients and 3,818 healthy controls, and an African-American set of 1,569 patients and 1,893 healthy controls. Imputation in 3,004 WTCCC additional control individuals was also performed. Genetic association between the genotyped markers was determined, and pair-wise conditional analysis was performed to localize the independent genetic effect in the IL2/IL21 locus in lupus. Results We established and confirmed the genetic association between IL2/IL21 and lupus. Using conditional analysis and trans-ethnic mapping, we localized the genetic effect in this locus to two SNPs in high linkage disequilibrium; rs907715 located within IL21 (OR=1.16 (1.101.22), P= 2.17 10?8), and rs6835457 located in the 3-UTR flanking region of IL21 (OR= 1.11 (1.051.17), P= 9.3510?5). Conclusion We have established the genetic association between lupus and IL2/IL21 with a genome-wide level of significance. Further, we localized this genetic association within the IL2/IL21 linkage disequilibrium block to IL21. If other autoimmune IL2/IL21 genetic associations are similarly localized, then the IL21 risk alleles would be predicted to operate in a fundamental mechanism that influences the course of a number of autoimmune disease processes. PMID:21425124

Hughes, Travis; Kim-Howard, Xana; Kelly, Jennifer A.; Kaufman, Kenneth M.; Langefeld, Carl D.; Ziegler, Julie; Sanchez, Elena; Kimberly, Robert P.; Edberg, Jeffrey C.; Ramsey-Goldman, Rosalind; Petri, Michelle; Reveille, John D.; Martin, Javier; Brown, Elizabeth E.; Vil, Luis M.; Alarcn, Graciela S.; James, Judith A.; Gilkeson, Gary S.; Moser, Kathy L.; Gaffney, Patrick M.; Merrill, Joan T.; Vyse, Timothy J.; Alarcn-Riquelme, Marta E.; Nath, Swapan K.; Harley, John B.; Sawalha, Amr H.

2011-01-01

443

Development of a novel noncompetitive antagonist of IL-1 receptor.  

PubMed

IL-1 is a major proinflammatory cytokine which interacts with the IL-1 receptor I (IL-1RI) complex, composed of IL-1RI and IL-1R accessory protein subunits. Currently available strategies to counter pathological IL-1 signaling rely on a recombinant IL-1 receptor antagonist, which directly competes with IL-1 for its binding site. Presently, there are no small antagonists of the IL-1RI complex. Given this void, we derived 15 peptides from loops of IL-1R accessory protein, which are putative interactive sites with the IL-1RI subunit. In this study, we substantiate the merits of one of these peptides, rytvela (we termed "101.10"), as an inhibitor of IL-1R and describe its properties consistent with those of an allosteric negative modulator. 101.10 (IC(50) approximately 1 nM) blocked human thymocyte proliferation in vitro, and demonstrated robust in vivo effects in models of hyperthermia and inflammatory bowel disease as well as topically in contact dermatitis, superior to corticosteroids and IL-1ra; 101.10 did not bind to IL-1RI deficient cells and was ineffective in vivo in IL-1RI knockout mice. Importantly, characterization of 101.10, revealed noncompetitive antagonist actions and functional selectivity by blocking certain IL-1R pathways while not affecting others. Findings describe the discovery of a potent and specific small (peptide) antagonist of IL-1RI, with properties in line with an allosteric negative modulator. PMID:18453620

Quiniou, Christiane; Sapieha, Przemyslaw; Lahaie, Isabelle; Hou, Xin; Brault, Sonia; Beauchamp, Martin; Leduc, Martin; Rihakova, Lenka; Joyal, Jean-Sbastien; Nadeau, Sylvain; Heveker, Nikolaus; Lubell, William; Sennlaub, Florian; Gobeil, Fernand; Miller, Greg; Pshezhetsky, Alexey V; Chemtob, Sylvain

2008-05-15

444

Dendritic Cell IL-1? and IL-1? Are Polyubiquitinated and Degraded by the Proteasome*  

PubMed Central

IL-1? and ? are key players in the innate immune system. The secretion of these cytokines by dendritic cells (DC) is integral to the development of proinflammatory responses. These cytokines are not secreted via the classical secretory pathway. Instead, 2 independent processes are required; an initial signal to induce up-regulation of the precursor pro-IL-1? and -?, and a second signal to drive cleavage and consequent secretion. Pro-IL-1? and -? are both cytosolic and thus, are potentially subject to post-translational modifications. These modifications may, in turn, have a functional outcome in the context of IL-1? and -? secretion and hence inflammation. We report here that IL-1? and -? were degraded intracellularly in murine bone marrow-derived DC and that this degradation was dependent on active cellular processes. In addition, we demonstrate that degradation was ablated when the proteasome was inhibited, whereas autophagy did not appear to play a major role. Furthermore, inhibition of the proteasome led to an accumulation of polyubiquitinated IL-1? and -?, indicating that IL-1? and -? were polyubiquitinated prior to proteasomal degradation. Finally, our investigations suggest that polyubiquitination and proteasomal degradation are not continuous processes but instead are up-regulated following DC activation. Overall, these data highlight that IL-1? and -? polyubiquitination and proteasomal degradation are central mechanisms in the regulation of intracellular IL-1 levels in DC. PMID:25371210

Ainscough, Joseph S.; Frank Gerberick, G.; Zahedi-Nejad, Maryam; Lopez-Castejon, Gloria; Brough, David; Kimber, Ian; Dearman, Rebecca J.

2014-01-01

445

Distinct Licensing of IL-18 and IL-1? Secretion in Response to NLRP3 Inflammasome Activation  

PubMed Central

Inflammasome activation permits processing of interleukins (IL)-1? and 18 and elicits cell death (pyroptosis). Whether these responses are independently licensed or are hard-wired consequences of caspase-1 (casp1) activity has not been clear. Here, we show that that each of these responses is independently regulated following activation of NLRP3 inflammasomes by a non-canonical stimulus, the secreted Listeria monocytogenes (Lm) p60 protein. Primed murine dendritic cells (DCs) responded to p60 stimulation with reactive oxygen species (ROS) production and secretion of IL-1? and IL-18 but not pyroptosis. Inhibitors of ROS production inhibited secretion of IL-1?, but did not impair IL-18 secretion. Furthermore, DCs from caspase-11 (casp11)-deficient 129S6 mice failed to secrete IL-1? in response to p60 but were fully responsive for IL-18 secretion. These findings reveal that there are distinct licensing requirements for processing of IL-18 versus IL-1? by NLRP3 inflammasomes. PMID:23028835

Schmidt, Rebecca L.; Lenz, Laurel L.

2012-01-01

446

Endoplasmic reticulum stress impairs IL-4/IL-13 signaling through C/EBP?-mediated transcriptional suppression  

PubMed Central

Summary Activation of the unfolded protein response (UPR) by endoplasmic reticulum (ER) stress culminates in extensive gene regulation, with transcriptional upregulation of genes that improve the protein folding capacity of the organelle. However, a substantial number of genes are downregulated by ER stress, and the mechanisms that lead to this downregulation and its consequences on cellular function are poorly understood. We found that ER stress led to coordinated transcriptional suppression of diverse cellular processes, including those involved in cytokine signaling. Using expression of the IL-4/IL-13 receptor subunit Il4ra as a sentinel, we sought to understand the mechanism behind this suppression and its impact on inflammatory signaling. We found that reinitiation of global protein synthesis by GADD34-mediated dephosphorylation of eIF2? resulted in preferential expression of the inhibitory LIP isoform of the transcription factor C/EBP?. This regulation was in turn required for the suppression of Il4ra and related inflammatory genes. Suppression of Il4ra was lost in Cebpb?/? cells but could be induced by LIP overexpression. As a consequence of Il4ra suppression, ER stress impaired IL-4/IL-13 signaling. Strikingly, Cebpb?/? cells lacking Il4ra downregulation were protected from this signaling impairment. This work identifies a novel role for C/EBP? in regulating transcriptional suppression and inflammatory signaling during ER stress. PMID:23813955

Arensdorf, Angela M.; Thomas Rutkowski, D.

2013-01-01

447

Hawaii Volcanoes National Park Traffic and Parking: Current Issues, Future Solutions Hawaii Volcanoes National Park (HAVO) is experiencing increased visitor use and congestion/  

E-print Network

Hawaii Volcanoes National Park Traffic and Parking: Current Issues, Future Solutions Hawaii, and unsafe practices. This project will record and analyze these issues. NPS staff and University of Hawaii

Prevedouros, Panos D.

448

Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex  

SciTech Connect

Interleukin-20 (IL-20) is an IL-10-family cytokine that regulates innate and adaptive immunity in skin and other tissues. In addition to protecting the host from various external pathogens, dysregulated IL-20 signaling has been shown to contribute to the pathogenesis of human psoriasis. IL-20 signals through two cell-surface receptor heterodimers, IL-20R1-IL-20R2 and IL-22R1-IL-20R2. In this report, crystals of the IL-20-IL-20R1-IL-20R2 ternary complex have been grown from polyethylene glycol solutions. The crystals belonged to space group P4{sub 1}2{sub 1}2 or P4{sub 3}2{sub 1}2, with unit-cell parameters a = 111, c = 135 {angstrom}, and diffracted X-rays to 3 {angstrom} resolution. The crystallographic asymmetric unit contains one IL-20-IL-20R1-IL-20R2 complex, corresponding to a solvent content of approximately 54%.

Logsdon, Naomi J.; Allen, Christopher E.; Rajashankar, Kanagalaghatta R.; Walter, Mark R. (Cornell); (UAB)

2012-02-08

449

The augmented lagrange multipliers method for matrix completion from corrupted samplings with application to mixed Gaussian-impulse noise removal.  

PubMed

This paper studies the problem of the restoration of images corrupted by mixed Gaussian-impulse noise. In recent years, low-rank matrix reconstruction has become a research hotspot in many scientific and engineering domains such as machine learning, image processing, computer vision and bioinformatics, which mainly involves the problem of matrix completion and robust principal component analysis, namely recovering a low-rank matrix from an incomplete but accurate sampling subset of its entries and from an observed data matrix with an unknown fraction of its entries being arbitrarily corrupted, respectively. Inspired by these ideas, we consider the problem of recovering a low-rank matrix from an incomplete sampling subset of its entries with an unknown fraction of the samplings contaminated by arbitrary errors, which is defined as the problem of matrix completion from corrupted samplings and modeled as a convex optimization problem that minimizes a combination of the nuclear norm and the l(1)-norm in this paper. Meanwhile, we put forward a novel and effective algorithm called augmented Lagrange multipliers to exactly solve the problem. For mixed Gaussian-impulse noise removal, we regard it as the problem of matrix completion from corrupted samplings, and restore the noisy image following an impulse-detecting procedure. Compared with some existing methods for mixed noise removal, the recovery quality performance of our method is dominant if images possess low-rank features such as geometrically regular textures and similar structured contents; especially when the density of impulse noise is relatively high and the variance of Gaussian noise is small, our method can outperform the traditional methods significantly not only in the simultaneous removal of Gaussian noise and impulse noise, and the restoration ability for a low-rank image matrix, but also in the preservation of textures and details in the image. PMID:25248103

Meng, Fan; Yang, Xiaomei; Zhou, Chenghu

2014-01-01

450

Feasibility of cooling the Earth with a cloud of small spacecraft near the inner Lagrange point (L1)  

PubMed Central

If it were to become apparent that dangerous changes in global climate were inevitable, despite greenhouse gas controls, active methods to cool the Earth on an emergency basis might be desirable. The concept considered here is to block 1.8% of the solar flux with a space sunshade orbited near the inner Lagrange point (L1), in-line between the Earth and sun. Following the work of J. Early [Early, JT (1989) J Br Interplanet Soc 42:567569], transparent material would be used to deflect the sunlight, rather than to absorb it, to minimize the shift in balance out from L1 caused by radiation pressure. Three advances aimed at practical implementation are presented. First is an optical design for a very thin refractive screen with low reflectivity, leading to a total sunshade mass of ?20 million tons. Second is a concept aimed at reducing transportation cost to $50/kg by using electromagnetic acceleration to escape Earth's gravity, followed by ion propulsion. Third is an implementation of the sunshade as a cloud of many spacecraft, autonomously stabilized by modulating solar radiation pressure. These meter-sized flyers would be assembled completely before launch, avoiding any need for construction or unfolding in space. They would weigh a gram each, be launched in stacks of 800,000, and remain for a projected lifetime of 50 years within a 100,000-km-long cloud. The concept builds on existing technologies. It seems feasible that it could be developed and deployed in ?25 years at a cost of a few trillion dollars, <0.5% of world gross domestic product (GDP) over that time. PMID:17085589

Angel, Roger

2006-01-01

451

The Augmented Lagrange Multipliers Method for Matrix Completion from Corrupted Samplings with Application to Mixed Gaussian-Impulse Noise Removal  

PubMed Central

This paper studies the problem of the restoration of images corrupted by mixed Gaussian-impulse noise. In recent years, low-rank matrix reconstruction has become a research hotspot in many scientific and engineering domains such as machine learning, image processing, computer vision and bioinformatics, which mainly involves the problem of matrix completion and robust principal component analysis, namely recovering a low-rank matrix from an incomplete but accurate sampling subset of its entries and from an observed data matrix with an unknown fraction of its entries being arbitrarily corrupted, respectively. Inspired by these ideas, we consider the problem of recovering a low-rank matrix from an incomplete sampling subset of its entries with an unknown fraction of the samplings contaminated by arbitrary errors, which is defined as the problem of matrix completion from corrupted samplings and modeled as a convex optimization problem that minimizes a combination of the nuclear norm and the -norm in this paper. Meanwhile, we put forward a novel and effective algorithm called augmented Lagrange multipliers to exactly solve the problem. For mixed Gaussian-impulse noise removal, we regard it as the problem of matrix completion from corrupted samplings, and restore the noisy image following an impulse-detecting procedure. Compared with some existing methods for mixed noise removal, the recovery quality performance of our method is dominant if images possess low-rank features such as geometrically regular textures and similar structured contents; especially when the density of impulse noise is relatively high and the variance of Gaussian noise is small, our method can outperform the traditional methods significantly not only in the simultaneous removal of Gaussian noise and impulse noise, and the restoration ability for a low-rank image matrix, but also in the preservation of textures and details in the image. PMID:25248103

Meng, Fan; Yang, Xiaomei; Zhou, Chenghu

2014-01-01

452

Azimuthal extent and properties of midtail plasmoids from two-point ARTEMIS observations at the Earth-Moon Lagrange points  

NASA Astrophysics Data System (ADS)

distant-tail plasmoids are perceived to extend across most of the magnetotail (~40 RE), recent studies in the near-Earth region (X > -30 RE) have revealed that near-Earth reconnection (where plasmoids originate) is likely localized and takes place preferentially on the duskside. This discrepancy in plasmoid azimuthal extent suggests that a plasmoid may grow as it moves from near-Earth to the distant tail. Comprehensive multipoint, midtail plasmoid observations can be used to test this hypothesis. Between October 2010 and July 2011 the ARTEMIS spacecraft (P1 and P2) at the Earth-Moon Lagrange points (midtail, X ~ -45 to -65 RE) provided simultaneous two-point observations across the magnetotail for 4 days every lunar month, with a large range of spacecraft separations (0.1 to 25 RE). We find that plasmoids near lunar orbit, like other near-Earth reconnection-related phenomena, occur preferentially on the duskside of the magnetotail. Two-point ARTEMIS observations reveal that the typical plasmoid azimuthal size in our data set is about 5 to 10 RE, much smaller than expected from previous distant-tail observations. Plasmoids with an azimuthal size greater than 9 RE also exist but only at geomagnetic activity levels higher (AEpeak > 400 nT) than typically found in our data set (median AEpeak ~ 230 nT for our plasmoid data set and median AE ~ 100 nT during the entire period of ARTEMIS magnetotail observations). We conclude that plasmoids during small to moderate substorms (AEpeak < 400 nT) do not grow beyond ~10 RE until they have moved tailward of ~ -45 to -65 RE. Plasmoids during large substorms (AEpeak > 400 nT), however, either grow beyond ~10 RE before they reach lunar distance or initially extend across a large portion of the magnetotail.

Li, S.-S.; Angelopoulos, V.; Runov, A.; Kiehas, S. A.

2014-03-01

453

ParkingPermit.docx 11/2/2012 Eligibility for Visitors/Temporary Parking Permits  

E-print Network

employees) to the Statler College can receive a single day visitor Parking Permit for lots 40, 41, 44 campus can park on Evansdale campus in lots 42, 44(54), 45, 46, 50, or 52. Maps found at ... http://www.its.statler

Mohaghegh, Shahab

454

Bark in the Park: A Review of Domestic Dogs in Parks  

NASA Astrophysics Data System (ADS)

The presence of domestic dogs Canis familiaris in public open spaces is increasingly controversial. In our review of the literature, we located 133 publications of various types (papers, reports etc.) that examine some aspect of dogs in parks and open spaces (50 % focussed solely on dogs). There has been an exponential growth in the cumulative number of articles ( R 2 = 0.96; 82 % published since 1997); almost all pertain to temperate latitudes (97 %) and most to the northern hemisphere (62 %). Most articles focus on impacts on wildlife (51 %), zoonotic diseases (17 %), and people's perceptions regarding dogs (12 %). Articles mostly describe problems associated with dogs, while reports of low compliance with dog regulations are common. We outline six major findings regarding dogs in parks: (1) there is a paucity of information on dogs in parks, particularly in relation to their interactions with wildlife and regarding their management; (2) published studies are mainly restricted to a handful of locations in developed countries; (3) sectors of societies hold different views over the desirability of dogs in parks; (4) the benefits and risks of dogs to humans and park values are poorly documented and known; (5) dogs represent a notable disease risk in some but not all countries; and (6) coastal parks are over-represented in the literature in terms of potential negative impacts. Park managers globally require better information to achieve conservation outcomes from dog management in parks.

Weston, Michael A.; Fitzsimons, James A.; Wescott, Geoffrey; Miller, Kelly K.; Ekanayake, Kasun B.; Schneider, Thomas

2014-09-01

455

Public Parking is available at an hourly rate at the University Square car park.  

E-print Network

Public Parking is available at an hourly rate at the University Square car park. Enter via Bouverie, Parkville ABSTRACT: There were search engines before Google, and they should have served us well, but spammers were able to render early search engines useless. The key innovations in Google -- Page

Heiser, Gernot

456

Assessment of Soil Erosion at a DC Park Facility Spring Valley Park  

E-print Network

1 Assessment of Soil Erosion at a DC Park Facility Spring Valley Park NW Washington, DC Annual of this project is to provide a preliminary site inventory and assessment of soil erosion for the Spring Valley erosion. Due to its location relative to the University and small size it was determined to be an ideal

District of Columbia, University of the

457

Job Placement Manual: Forest Park Senior High School: Forest Park, Georgia.  

ERIC Educational Resources Information Center

The job placement manual of Forest Park Senior High School, Forest Park, Georgia, assists in producing a more effective program by providing specific job placement procedures for the high school. The 1,900 student high school, located in a suburban area south of Atlanta, had 522 graduates in 1974 (42 percent--college-bound, 10 percent--technical

Simpson, Wayne

458

Roadmap: Recreation, Park and Tourism Management Park Management Bachelor of Science  

E-print Network

16000 Foundations of Recreation and Leisure 3 US 10097 Destination Kent State: First Year Experience 1Roadmap: Recreation, Park and Tourism Management ­ Park Management ­ Bachelor of Science [EH Diversity 4 Fulfills Kent Core Basic Sciences RPTM 26030 Recreation Group Leadership 3 PSYC 11762 General

Sheridan, Scott

459

Roadmap: Recreation, Park and Tourism Management Park Management Bachelor of Science  

E-print Network

16000 Foundations of Recreation and Leisure 3 US 10097 Destination Kent State: FYE 1 Not requiredRoadmap: Recreation, Park and Tourism Management ­ Park Management ­ Bachelor of Science [EH Requirements 3 Kent Core Requirements 3 Semester Two: [15 Credit Hours] RPTM 26030 Recreation Group Leadership

Sheridan, Scott

460

Interleukin (IL)-1 gene polymorphisms: relevance of disease severity associated alleles with IL-1beta and IL-1ra production in multiple sclerosis.  

PubMed Central

BACKGROUND: Multiple sclerosis (MS) is an autoimmune disorder, with a considerable genetic influence on susceptibility and disease course. Cytokines play an important role in MS pathophysiology, and genes encoding various cytokines are logical candidates to assess possible associations with MS susceptibility and disease course. We previously reported an association of a combination of polymorphisms in the interleukin (IL)-1B and IL-1 receptor antagonist (IL-1RN) genes (i.e. IL-1RN allele 2+/IL-1B(+3959)allele 2-) with disease severity in MS. Extending this observation, we investigated whether IL-1beta and IL-1ra production differed depending on carriership of this gene combination. METHODS: Twenty MS patients and 20 controls were selected based upon carriership of the specific combination. In whole blood, in vitro IL-1beta and IL-1ra production was determined by enzyme-linked immunosorbent-assay after 6 and 24 h of stimulation with lipopolysaccharide. RESULTS: Carriers of the specific combination produced more IL-1ra, especially in MS patients, although not significantly. IL-1ra production was significantly higher in individuals homozygous for IL-1RN allele 2. In patients, Il-1ra production was higher and IL-1beta production lower compared with controls. In primary progressive patients, the IL-1beta /IL-1ra ratio was significantly lower than in relapsing-remitting patients. CONCLUSION: Our results suggest higher in vitro IL-1ra production in carriers of IL-1RN allele 2, with an indication of an allelic dose-effect relationship. PMID:12775358

Schrijver, Hans M; van As, Jaco; Crusius, J Bart A; Dijkstra, Christien D; Uitdehaag, Bernard M J

2003-01-01

461

Construction of an Expression System for Bioactive IL-18 and Generation of Recombinant Canine Distemper Virus Expressing IL-18  

PubMed Central

ABSTRACT Interleukin 18 (IL-18) plays an important role in the T-helper-cell type 1 immune response against intracellular parasites, bacteria and viral infections. It has been widely used as an adjuvant for vaccines and as an anticancer agent. However, IL-18 protein lacks a typical signal sequence and requires cleavage into its mature active form by caspase 1. In this study, we constructed mammalian expression vectors carrying cDNA encoding mature canine IL-18 (cIL-18) or mouse IL-18 (mIL-18) fused to the human IL-2 (hIL-2) signal sequence. The expressed proIL-18 proteins were processed to their mature forms in the cells. The supernatants of cells transfected with these plasmids induced high interferon-? production in canine peripheral blood mononuclear cells or mouse splenocytes, respectively, indicating the secretion of bioactive IL-18. Using reverse genetics, we also generated a recombinant canine distemper virus that expresses cIL-18 or mIL-18 fused to the hIL-2 signal sequence. As expected, both recombinant viruses produced mature IL-18 in the infected cells, which secreted bioactive IL-18. These results indicate that the signal sequence from hIL-2 is suitable for the secretion of mature IL-18. These recombinant viruses can also potentially be used as immunoadjuvants and agents for anticancer therapies in vivo. PMID:24898077

LIU, Yuxiu; SATO, Hiroki; HAMANA, Masahiro; MOONAN, Navita Anisia; YONEDA, Misako; XIA, Xianzhu; KAI, Chieko

2014-01-01

462

IL12R?1?TM Is a Secreted Product of il12rb1 That Promotes Control of Extrapulmonary Tuberculosis.  

PubMed

IL12RB1 is a human gene that is important for resistance to Mycobacterium tuberculosis infection. IL12RB1 is expressed by multiple leukocyte lineages, and encodes a type I transmembrane protein (IL12R?1) that associates with IL12p40 and promotes the development of host-protective TH1cells. Recently, we observed that il12rb1-the mouse homolog of IL12RB1-is alternatively spliced by leukocytes to produce a second isoform (IL12R?1?TM) that has biological properties distinct from IL12R?1. Although the expression of IL12R?1?TM is elicited by M. tuberculosis in vivo, and its overexpression enhances IL12p40 responsiveness in vitro, the contribution of IL12R?1?TM to controlling M. tuberculosis infection has not been tested. Here, we demonstrate that IL12R?1?TM represents a secreted product of il12rb1 that, when absent from mice, compromises their ability to control M. tuberculosis infection in extrapulmonary organs. Furthermore, elevated M. tuberculosis burdens in IL12R?1?TM-deficient animals are associated with decreased lymph node cellularity and a decline in TH1 development. Collectively, these data support a model wherein IL12R?1?TM is a secreted product of il12rb1 that promotes resistance to M. tuberculosis infection by potentiating TH cells response to IL-12. PMID:25404030

Ray, Aurelie A; Fountain, Jeffrey J; Miller, Halli E; Cooper, Andrea M; Robinson, Richard T

2015-02-01

463

ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface.  

PubMed

Interleukin (IL)-1 is one of the most evolutionarily conserved cytokines and plays an essential role in the regulation of innate immunity. IL-1 binds to two different receptors, IL-1R1 and IL-1R2, which share approximately 28% amino acid homology. IL-1R1 contains a cytoplasmic domain and is capable of transducing cellular signals; by contrast, IL-1R2 lacks a functional cytoplasmic domain and serves as a decoy receptor for IL-1. Interestingly, IL-1R2 is proteolytically cleaved and also functions as a soluble receptor that blocks IL-1 activity. In the present study, we examined the shedding properties of IL-1R2 and demonstrate that ADAM17 is de facto the major sheddase for IL-1R2 and that introducing a mutation into the juxta-membrane domain of IL-1R2 significantly desensitizes IL-1R2 to proteolytic cleavage. IL-1R1 was almost insensitive to ADAM17-dependent cleavage; however, the replacement of the juxta-membrane domain of IL-R1 with that of IL-1R2 significantly increased the sensitivity of IL-1R1 to shedding. Furthermore, we demonstrate that ADAM17 indirectly enhances IL-1 signaling in a cell-autonomous manner by selectively cleaving IL-1R2. Taken together, the data collected in the present study indicate that ADAM17 affects sensitivity to IL-1 by changing the balance between IL-1R1 and the decoy receptor IL-1R2. PMID:25461404

Uchikawa, Shinichi; Yoda, Masaki; Tohmonda, Takahide; Kanaji, Arihiko; Matsumoto, Morio; Toyama, Yoshiaki; Horiuchi, Keisuke

2015-02-01

464

Decreto n. 342 IL RETTORE dipartimento risorse umane e organizzazione  

E-print Network

.10.2012, con cui il prof. Umberto Carabelli è stato nominato Direttore del Dipartimento di "Scienze Politiche del 17.01.2013 con cui il prof. Umberto Carabelli designa il prof. Ennio Triggiani, quale docente a sostituire il prof. Umberto Carabelli nelle funzioni di Direttore del Dipartimento di "Scienze Politiche

Malerba, Donato

465

Serum IL-9, IL-17, and TGF-? levels in subjects with diabetic kidney disease (CURES-134).  

PubMed

The role of inflammation in both diabetes and diabetic kidney disease (DKD) is becoming more widely accepted. However, the role of recently characterized T cell cytokines interleukin (IL)-9 and IL-17 in diabetes and especially DKD is less well studied. Transforming growth factor beta (TGF-?) controls the secretion of both of these cytokines. In this study, we estimated the levels of IL-9, IL-17, and TGF-? in the serum of subjects with normal glucose tolerance (NGT=88) and subjects with type 2 diabetes without (diabetes mellitus (DM)=65) and with DKD (DKD=97) using enzyme-linked immunosorbent assay (ELISA), and we correlated these levels with the clinical risk factors of diabetes and DKD. IL-17 levels showed a serial decline and TGF-? levels showed a serial increase from NGT to DM to DKD (p<0.001). However, the IL-9 levels were significantly reduced in the DM group compared to the NGT and DKD group (p<0.001). While TGF-? and IL-17 showed a positive and negative correlation, respectively, with fasting and postprandial glucose levels and glycated hemoglobin (HbA1c), IL-9 showed positive correlation with urea and microalbuminuria. Apart from pro-inflammatory cytokines, T helper (Th) cytokines might play an important role in insulin resistance and DKD. PMID:25542095

Vasanthakumar, Rathinam; Mohan, Viswanathan; Anand, Gowrisankar; Deepa, Mohan; Babu, Subash; Aravindhan, Vivekanandhan

2015-03-01

466

Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15R?.  

PubMed

IL-15 has growth-promoting effects on select lymphoid subsets, including natural killer (NK) cells, NK T cells, intraepithelial lymphocytes (IELs), CD8 T cells, and ??-T cells. Constitutive expression of murine IL-15 in IL-15-transgenic mice was reported to cause T-NK leukemia. We investigated whether IL-15 expression is sufficient for leukemic transformation using a human IL-15-transgenic (IL-15Tg) mouse model. We noted that 100% of the mice observed over a 2-year period (n > 150) developed fatal expansions of CD8 T cells with NK markers, and determined that these cells expressed IL-15 receptor alpha (IL-15R?). The expression of IL-15R? on CD8 T cells appears to be required for uncontrolled aggressive lymphoproliferation, because none of the IL-15R?(-/-)-IL-15Tg mice that we followed for more than 2 years developed the fatal disease despite controlled expansion of CD8 T cells. In addition, in contrast to IL-15Tg mice, in which leukemia-like CD8 T cells expressed IL-15R? persistently, acutely activated normal CD8 T cells only transiently expressed IL-15R?. Inhibition of DNA methylation enabled sustained IL-15R? expression induced by activation. We present a scenario for IL-15Tg mice in which CD8 T cells that acquire constitutive persistent IL-15R? expression are at a selective advantage and become founder cells, outgrow other lymphocytes, and lead to the establishment of a leukemia-like condition. PMID:21304101

Sato, Noriko; Sabzevari, Helen; Fu, Song; Ju, Wei; Petrus, Michael N; Bamford, Richard N; Waldmann, Thomas A; Tagaya, Yutaka

2011-04-14

467

IL-12R?1 deficiency: mutation update and description of the IL12RB1 variation database.  

PubMed

IL-12R?1 deficiency is an autosomal recessive disorder characterized by predisposition to recurrent and/or severe infections caused by otherwise poorly pathogenic mycobacteria and salmonella. IL-12R?1 is a receptor chain of both the IL-12 and the IL-23 receptor and deficiency of IL-12R?1 thus abolishes both IL-12 and IL-23 signaling. IL-12R?1 deficiency is caused by bi-allelic mutations in the IL12RB1 gene. Mutations resulting in premature stop codons, such as nonsense, frame shift, and splice site mutations, represent the majority of IL-12R?1 deficiency causing mutations (66%; 46/70). Also every other morbid mutation completely inactivates the IL-12R?1 protein. In addition to disease-causing mutations, rare and common variations with unknown functional effect have been reported in IL12RB1. All these variants have been deposited in the online IL12RB1 variation database (www.LOVD.nl/IL12RB1). In this article, we review the function of IL-12R?1 and molecular genetics of human IL12RB1. PMID:23864330

van de Vosse, Esther; Haverkamp, Margje H; Ramirez-Alejo, Noe; Martinez-Gallo, Mnica; Blancas-Galicia, Lizbeth; Metin, Ay?e; Garty, Ben Zion; Sun-Tan, a?man; Broides, Arnon; de Paus, Roelof A; Keskin, zlem; a?da?, Deniz; Tezcan, Ilhan; Lopez-Ruzafa, Encarna; Arstegui, Juan I; Levy, Jacov; Espinosa-Rosales, Francisco J; Sanal, zden; Santos-Argumedo, Leopoldo; Casanova, Jean-Laurent; Boisson-Dupuis, Stephanie; van Dissel, Jaap T; Bustamante, Jacinta

2013-10-01

468

IL-12R?1 deficiency: mutation update and description of the IL12RB1 variation database  

PubMed Central

IL-12R?1 deficiency is an autosomal recessive disorder characterized by predisposition to recurrent and/or severe infections caused by otherwise poorly pathogenic mycobacteria and salmonella. IL-12R?1 is a receptor chain of both the IL-12 and the IL-23 receptor and deficiency of IL-12R?1 thus abolishes both IL-12 and IL-23 signaling. IL-12R?1 deficiency is caused by bi-allelic mutations in the IL12RB1 gene. Mutations resulting in premature stop codons, such as nonsense, frame shift, and splice site mutations, represent the majority of IL-12R?1 deficiency causing mutations (66%; 46/70). Also every other morbid mutation completely inactivates the IL-12R?1 protein. In addition to disease-causing mutations, rare and common variations with unknown functional effect have been reported in IL12RB1. All these variants have been deposited in the online IL12RB1 variation database (www.LOVD.nl/IL12RB1). In this article, we review the function of IL-12R?1 and molecular genetics of human IL12RB1. PMID:23864330

van de Vosse, Esther; Haverkamp, Margje H.; Ramirez-Alejo, Noe; Martinez-Gallo, Mnica; Blancas-Galicia, Lizbeth; Metin, Ay?e; Garty, Ben Zion; Sun-Tan, a?man; Broides, Arnon; de Paus, Roelof A.; Keskin, zlem; a?da?, Deniz; Tezcan, Ilhan; Lopez-Ruzafa, Encarna; Arstegui, Juan I.; Levy, Jacov; Espinosa-Rosales, Francisco J.; Sanal, zden; Santos-Argumedo, Leopoldo; Casanova, Jean-Laurent; Boisson-Dupuis, Stephanie; van Dissel, Jaap T.; Bustamante, Jacinta

2014-01-01

469

The IL-13/IL-4R? axis is involved in tuberculosis-associated pathology.  

PubMed

Human tuberculosis (TB) is a leading global health threat and still constitutes a major medical challenge. However, mechanisms governing tissue pathology during post-primary TB remain elusive, partly because genetically or immunologically tractable animal models are lacking. In human TB, the demonstration of a large relative increase in interleukin (IL)-4 and IL-13 expression, which correlates with lung damage, indicates that a subversive T helper (TH)2 component in the response to Mycobacterium tuberculosis (Mtb) may undermine protective immunity and contribute to reactivation and tissue pathology. Up to now, there has been no clear evidence regarding whether IL-4/IL-13-IL-4 receptor-? (R?)-mediated mechanisms may in fact cause reactivation and pathology. Unfortunately, the virtual absence of centrally necrotizing granulomas in experimental murine TB is associated with a poor induction of a TH2 immune response. We therefore hypothesize that, in mice, an increased production of IL-13 may lead to a pathology similar to human post-primary TB. In our study, aerosol Mtb infection of IL-13-over-expressing mice in fact resulted in pulmonary centrally necrotizing granulomas with multinucleated giant cells, a hypoxic rim and a perinecrotic collagen capsule, with an adjacent zone of lipid-rich, acid-fast bacilli-containing foamy macrophages, thus strongly resembling the pathology in human post-primary TB. Granuloma necrosis (GN) in Mtb-infected IL-13-over-expressing mice was associated with the induction of arginase-1-expressing macrophages. Indirect blockade of the endogenous arginase inhibitor l-hydroxyarginine in Mtb-infected wild-type mice resulted in a strong arginase expression and precipitated a similar pathology of GN. Together, we here introduce an experimental TB model that displays many features of centrally necrotizing granulomas in human post-primary TB and demonstrate that IL-13/IL-4R?-dependent mechanisms leading to arginase-1 expression are involved in TB-associated tissue pathology. PMID:24979482

Heitmann, Lisa; Abad Dar, Mahin; Schreiber, Tanja; Erdmann, Hanna; Behrends, Jochen; Mckenzie, Andrew N J; Brombacher, Frank; Ehlers, Stefan; Hlscher, Christoph

2014-11-01

470

Identification of contact and respiratory sensitizers according to IL-4 receptor ? expression and IL-2 production.  

PubMed

Identification of allergenic chemicals is an important occupational safety issue. While several methods exist to identify contact sensitizers, there is currently no validated model to predict the potential of chemicals to act as respiratory sensitizers. Previously, we reported that cytometry analysis of the local immune responses induced in mice dermally exposed to the respiratory sensitizer trimellitic anhydride (TMA 10%) and contact sensitizer dinitrochlorobenzene (DNCB 1%) could identify divergent expression of several immune parameters. The present study confirms, first, that IgE-positive B cells, MHC class II molecules, interleukin (IL)-2, IL-4 and IL-4R? can differentiate the allergic reactions caused by high doses of strong respiratory (TMA, phthalic anhydride and toluene diisocyanate) and contact sensitizers (DNCB, dinitrofluorobenzene and oxazolone). The second part of the study was designed to test the robustness of these markers when classing the weakly immunogenic chemicals most often encountered. Six respiratory allergens, including TMA (2.5%), five contact allergens, including DNCB (0.25%), and two irritants were compared at doses of equivalent immunogenicity. The results indicated that IL-4R? and IL-2 can be reliably used to discriminate sensitizers. Respiratory sensitizers induced markedly higher IL-4R? levels than contact allergens, while irritants had no effect on this parameter. Inversely, contact allergens tended to induce higher percentages of IL-2?CD8? cells than respiratory allergens. In contrast, the markers MHC-II, IgE and IL-4 were not able to classify chemicals with low immunogenic potential. In conclusion, IL-4R? and IL-2 have the potential to be used in classifying a variety of chemical allergens. PMID:22381623

Goutet, Michle; Ppin, Elsa; Langonn, Isabelle; Huguet, Nelly; Ban, Masarin

2012-04-15

471

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.  

PubMed Central

Interleukin-15 (IL-15) is a novel cytokine of the four-helix bundle family which shares many biological activities with IL-2, probably due to its interaction with the IL-2 receptor beta and gamma (IL-2R beta and gamma c) chains. We report here the characterization and molecular cloning of a distinct murine IL-15R alpha chain. IL-15R alpha alone displays an affinity of binding for IL-15 equivalent to that of the heterotrimeric IL-2R for IL-2. A biologically functional heteromeric IL-15 receptor complex capable of mediating IL-15 responses was generated through reconstruction experiments in a murine myeloid cell line. IL-15R alpha is structurally similar to IL-2R alpha; together they define a new cytokine receptor family. The distribution of IL-15 and IL-15R alpha mRNA suggests that IL-15 may have biological activities distinct from IL-2. Images PMID:7641685

Giri, J G; Kumaki, S; Ahdieh, M; Friend, D J; Loomis, A; Shanebeck, K; DuBose, R; Cosman, D; Park, L S; Anderson, D M

1995-01-01

472

The Schome Park Programme: Exploring Educational Alternatives  

NASA Astrophysics Data System (ADS)

The Schome Park Programme set out to extend thinking about what the education system for the information age (Schome) should be like. The first three phases of the programme spanned 13 months and involved the use of Schome Park, our "closed" island(s) in Teen Second LifeTM (TSL) virtual world alongside a wiki and forum. During this time approximately two hundred 13-17 year olds and around 50 adults were given access to Schome Park. Having explained the context in which this work took place the paper outlines the initial educational design underpinning the programme and describes some of the activities which took place. It goes on to explore some dimensions of practice which emerged from the data analysis towards the end of Phase 3, focusing on learner experiences of experimentation, playfulness, curriculum, choice, participation and the expression of the learner voice.

Twining, Peter; Footring, Shri

473

Falls of the Ohio State Park  

NSDL National Science Digital Library

Falls of the Ohio State Park, on the banks of the Ohio river, is home to 386 million year old fossil beds, among the largest naturally exposed Devonian fossil beds in the world. The interpretive center, featuring a video presentation and exhibit gallery, overlooks the fossil beds. The Park holds a number of special events throughout the year, including fossil bed hikes, Young Paleontologist camp, summer programs for kids, geology, archeology, and paleontology workshops, and environmental education. There are several downloadable resources from the website, including illustrated information on brachiopods, crinoids, and trilobites, as well as activities to foster learning about life in the Devonian seas. In addition to the interpretive center, there are the Ohio River and Coral Reef Aquariums where visitors can view many species of fish, corals and other invertebrates. While fossil collecting is prohibited, the park staff encourages visitors to explore and discover the many different types of fossils that can be found on the ancient sea bottom.

474

Interleukin (IL)-10, IL-1ra and IL-12 profiles in active and quiescent systemic lupus erythematosus: could longitudinal studies reveal patient subgroups of differing pathology?  

PubMed

Several cytokines have been implicated individually in the pathogenesis of systemic lupus erythematosus (SLE) and some, including interleukin (IL)-10, IL-12 and IL-1ra are raised during flares of disease activity. Few studies have been directed at examining the interactions between these cytokines and how their combined profile relates to disease activity. We have examined serum levels of IL-10, IL-12 and IL-1ra in a cohort of SLE patients obtained from the Queen Elizabeth Hospital, Birmingham in cross-sectional and, in a smaller group, longitudinal analyses. In the cross-sectional study, there were significant correlations between levels of the three cytokines. There were also significant correlations between levels of each cytokine and measures of disease activity. IL-10 levels correlated with ESR, anti-dsDNA antibody titres and C3D, IL-12 levels with anti-dsDNA antibody titres and IL-1ra levels with ESR, anti-dsDNA antibody titres and C3D. IL-1ra levels also correlated with CRP. Circulating IL-10 and IL-1ra levels were higher in patients with SLE than in normal controls, although in this study group they did not reach significance. Circulating IL-12 levels were, however, significantly higher in SLE compared to controls. This was true both in patients with active disease and those sampled during a quiescent phase. These data add to the evidence that cytokines such as IL-10, IL-12 and IL-1ra are important in SLE pathogenesis. In a retrospective study of serial serum samples from seven patients, we found two patients whose cytokine profile was very different from the rest of the group. In most patients normalized IL-10, IL-12 and IL-1ra levels mirrored BILAG scores closely, but in these two patients, IL-10, IL-12 and IL-1ra levels did not fluctuate with disease activity. It is possible that there is a subgroup of SLE patients whose cytokine profile could be an important indicator of their pathology. In order to confirm this and determine the frequency of such patients this study needs to be repeated with a much larger subject group. The coexistence of patient groups with different patterns of cytokine activity might explain conflicting reports of associations of levels of particular cytokines with SLE. As the observed differences could reflect different aetiologies of SLE, this information could reveal valuable endophenotypes for genetic and functional studies of SLE and might, ultimately, inform therapeutic management. PMID:15498048

Capper, E R; Maskill, J K; Gordon, C; Blakemore, A I F

2004-11-01

475

Interleukin (IL)-10, IL-1ra and IL-12 profiles in active and quiescent systemic lupus erythematosus: could longitudinal studies reveal patient subgroups of differing pathology?  

PubMed Central

Several cytokines have been implicated individually in the pathogenesis of systemic lupus erythematosus (SLE) and some, including interleukin (IL)-10, IL-12 and IL-1ra are raised during flares of disease activity. Few studies have been directed at examining the interactions between these cytokines and how their combined profile relates to disease activity. We have examined serum levels of IL-10, IL-12 and IL-1ra in a cohort of SLE patients obtained from the Queen Elizabeth Hospital, Birmingham in cross-sectional and, in a smaller group, longitudinal analyses. In the cross-sectional study, there were significant correlations between levels of the three cytokines. There were also significant correlations between levels of each cytokine and measures of disease activity. IL-10 levels correlated with ESR, anti-dsDNA antibody titres and C3D, IL-12 levels with anti-dsDNA antibody titres and IL-1ra levels with ESR, anti-dsDNA antibody titres and C3D. IL-1ra levels also correlated with CRP. Circulating IL-10 and IL-1ra levels were higher in patients with SLE than in normal controls, although in this study group they did not reach significance. Circulating IL-12 levels were, however, significantly higher in SLE compared to controls. This was true both in patients with active disease and those sampled during a quiescent phase. These data add to the evidence that cytokines such as IL-10, IL-12 and IL-1ra are important in SLE pathogenesis. In a retrospective study of serial serum samples from seven patients, we found two patients whose cytokine profile was very different from the rest of the group. In most patients normalized IL-10, IL-12 and IL-1ra levels mirrored BILAG scores closely, but in these two patients, IL-10, IL-12 and IL-1ra levels did not fluctuate with disease activity. It is possible that there is a subgroup of SLE patients whose cytokine profile could be an important indicator of their pathology. In order to confirm this and determine the frequency of such patients this study needs to be repeated with a much larger subject group. The coexistence of patient groups with different patterns of cytokine activity might explain conflicting reports of associations of levels of particular cytokines with SLE. As the observed differences could reflect different aetiologies of SLE, this information could reveal valuable endophenotypes for genetic and functional studies of SLE and might, ultimately, inform therapeutic management. PMID:15498048

CAPPER, E R; MASKILL, J K; GORDON, C; BLAKEMORE, A I F

2004-01-01

476

Novel p19 Protein Engages IL12p40 to Form a Cytokine, IL23, with Biological Activities Similar as Well as Distinct from IL12  

Microsoft Academic Search

A novel sequence discovered in a computational screen appears distantly related to the p35 subunit of IL-12. This factor, which we term p19, shows no biological activity by itself; instead, it combines with the p40 subunit of IL-12 to form a novel, biologically active, composite cytokine, which we term IL-23. Activated dendritic cells secrete detectable levels of this complex. IL-23

Birgit Oppmann; Robin Lesley; Bianca Blom; Jackie C Timans; Yuming Xu; Brisdell Hunte; Felix Vega; Nancy Yu; Jing Wang; Komal Singh; Francesca Zonin; Elena Vaisberg; Tatyana Churakova; Man-ru Liu; Daniel Gorman; Janet Wagner; Sandra Zurawski; Yong-Jun Liu; John S Abrams; Kevin W Moore; Donna Rennick; Rene de Waal-Malefyt; Charles Hannum; J. Fernando Bazan; Robert A Kastelein

2000-01-01

477

Evaluation of heterophilic antibody blocking agents in reducing false positive interference in immunoassays for IL17AA, IL17FF, and IL17AF  

Microsoft Academic Search

IL-17AA, IL-17FF, and IL-17AF are proinflammatory cytokines that have been implicated in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA). In order to measure the levels of these cytokines in synovial fluid and serum samples from RA patients, immunoassays specific for IL-17AA, FF, and AF were developed. Although these assays could tolerate up to 50% pooled normal human

Laura E. DeForge; Kelly M. Loyet; Donnie Delarosa; Jason Chinn; Fojan Zamanian; Anan Chuntharapai; James Lee; Phil Hass; Nathan Wei; Michael J. Townsend; Jianyong Wang; Wai Lee T. Wong

2010-01-01

478

Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-?-induced cardiomyocyte death.  

PubMed

Recurrent or sustained inflammation plays a causal role in the development and progression of left ventricular hypertrophy (LVH) and its transition to failure. Interleukin (IL)-18 is a potent pro-hypertrophic inflammatory cytokine. We report that induction of pressure overload in the rabbit, by constriction of the descending thoracic aorta induces compensatory hypertrophy at 4weeks (mass/volume ratio: 1.70.11) and ventricular dilatation indicative of heart failure at 6weeks (mass/volume ratio: 0.70.04). In concordance with this, fractional shortening was preserved at 4weeks, but markedly attenuated at 6weeks. We cloned rabbit IL-18, IL-18R?, IL-18R?, and IL-18 binding protein (IL-18BP) cDNA, and show that pressure overload, while enhancing IL-18 and IL-18R expression in hypertrophied and failing hearts, markedly attenuated the level of expression of the endogenous IL-18 antagonist IL-18BP. Cyclical mechanical stretch (10% cyclic equibiaxial stretch, 1Hz) induced hypertrophy of primary rabbit cardiomyocytes in vitro and enhanced ANP, IL-18, and IL-18R? expression. Further, treatment with rhIL-18 induced its own expression and that of IL-18R? via AP-1 activation, and induced cardiomyocyte hypertrophy in part via PI3K/Akt/GATA4 signaling. In contrast, IL-18 potentiated TNF-?-induced cardiomyocyte death, and by itself induced cardiac endothelial cell death. These results demonstrate that pressure overload is associated with enhanced IL-18 and its receptor expression in hypertrophied and failingrabbit hearts. Since IL-18BP expression is markedly inhibited, our results indicate a positive amplification in IL-18 proinflammatory signaling during pressure overload, and suggest IL-18 as a potential therapeutic target in pathological hypertrophy and cardiac failure. PMID:25108227

Yoshida, Tadashi; Friehs, Ingeborg; Mummidi, Srinivas; del Nido, Pedro J; Addulnour-Nakhoul, Solange; Delafontaine, Patrice; Valente, Anthony J; Chandrasekar, Bysani

2014-10-01

479

Impact of IL-1 signalling on experimental uveitis and arthritis  

PubMed Central

Background Uveitis, or inflammatory eye disease, is a common extra-articular manifestation of many systemic autoinflammatory diseases involving the joints. Anakinra (recombinant interleukin (IL)-1 receptor antagonist (Ra)) is an effective therapy in several arthritic diseases; yet, few studies have investigated the extent to which IL-1 signalling or IL-1Ra influences the onset and/or severity of uveitis. Objective To seek possible links between arthritis and uveitis pathogenesis related to IL-1 signalling. Methods The eyes of IL-1Ra-deficient BALB/c mice were monitored histologically and by intravital videomicroscopy to determine if uveitis developed along with the expected spontaneous arthritis in ankles and knees. Expression levels of IL-1R and its negative regulators (IL-1Ra, IL-1RII, IL-1RAcP and single Ig IL-1R-related molecule) in eye and joint tissues were compared. Differences in uveitis induced by intraocular injection of lipopolysaccharide (LPS) in mice lacking IL-1R or IL-1Ra were assessed. Results Deficiency in IL-1Ra predisposes to spontaneous arthritis, which is exacerbated by previous systemic LPS exposure. The eye, however, does not develop inflammatory disease despite the progressive arthritis or LPS exposure. Organ-specific expression patterns for IL-1Ra and negative regulators of IL-1 activity were observed that appear to predict predisposition to inflammation in each location in IL-1Ra knockout mice. The eye is extremely sensitive to locally administered LPS, and IL-1Ra deficiency markedly exacerbates the resulting uveitis. Conclusion This study demonstrates that IL-1Ra plays an important role in suppressing local responses in eyes injected with LPS and that there is discordance between murine eyes and joints in the extent to which IL-1Ra protects against spontaneous inflammation. PMID:22267332

Planck, Stephen R; Woods, April; Clowers, Jenna S; Nicklin, Martin J; Rosenbaum, James T; Rosenzweig, Holly L

2012-01-01

480

IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut?  

PubMed Central

Regulatory B cells (Breg) have attracted increasing attention for their roles in maintaining peripheral tolerance. Interleukin 33 (IL-33) is a recently identified IL-1 family member, which leads a double-life with both pro- and anti-inflammatory properties. We report here that peritoneal injection of IL-33 exacerbated inflammatory bowel disease in IL-10-deficient (IL-10?/?) mice, whereas IL-33-treated IL-10-sufficient (wild type) mice were protected from the disease induction. A phenotypically unconventional subset(s) (CD19+CD25+CD1dhiIgMhiCD5-CD23-Tim-1-) of IL-10 producing Breg-like cells (BregIL-33) was identified responsible for the protection. We demonstrated further that BregIL-33 isolated from these mice could suppress immune effector cell expansion and functions and, upon adoptive transfer, effectively blocked the development of spontaneous colitis in IL-10?/? mice. Our findings indicate an essential protective role, hence therapeutic potential, of BregIL-33 against mucosal inflammatory disorders in thegut. PMID:24491821

Sattler, Susanne; Ling, Guang-Sheng; Xu, Damo; Hussaarts, Leonie; Romaine, Andreas; Zhao, Hongzhi; Fossati-Jimack, Liliane; Malik, Talat; Cook, H. Terence; Botto, Marina; Lau, Yu-Lung; Smits, Hermelijn H.; Liew, Foo Y.; Huang, Fang-Ping

2014-01-01