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1

International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)  

E-print Network

International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009 and Nuclear Engineering Troy, New York, 12180 D.P. Barry, G. Leinweber, N.J. Drindak (ret.), J.G. Hoole Knolls

Danon, Yaron

2

International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)  

E-print Network

International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009.P. Barry Department of Mechanical Aerospace and Nuclear Engineering, Rensselaer Polytechnic Institute 110 8

Danon, Yaron

3

American Nuclear Society 2013 Student Conference Massachusetts Institute of Technology Boston, Massachusetts, USA, April 4-6, 2013, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2013)  

E-print Network

American Nuclear Society 2013 Student Conference ­ Massachusetts Institute of Technology Boston, Massachusetts, USA, April 4-6, 2013, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2013) A DETECTOR of the total energy principle, shown to scale #12;McDermott et al. American Nuclear Society 2013 Student

Danon, Yaron

4

Sixth American Nuclear Society International Topical Meeting on Nuclear Plant Instrumentation, Control, and Human-Machine Interface Technologies NPIC&HMIT 2009, Knoxville, Tennessee, April 5-9, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL  

E-print Network

Sixth American Nuclear Society International Topical Meeting on Nuclear Plant Instrumentation, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009) FUELASSEMBLY SELF SHIELDING Polytechnic Institute Department of Mechanical, Aerospace and Nuclear Engineering Romanc2@rpi.edu; Danony

Danon, Yaron

5

75 FR 3253 - Lamb Assembly and Test, LLC, Subsidiary of Mag Industrial Automation Systems, Machesney Park, IL...  

Federal Register 2010, 2011, 2012, 2013

...LLC, Subsidiary of Mag Industrial Automation Systems, Machesney Park, IL; Notice...based on the finding that imports of automation equipment and machine tools did not...The survey revealed no imports of automation equipment and machine tools by...

2010-01-20

6

The Lagrange Points  

ERIC Educational Resources Information Center

This paper presents a derivation of all five Lagrange points by methods accessible to sixth-form students, and provides a further opportunity to match Newtonian gravity with centripetal force. The predictive powers of good scientific theories are also discussed with regard to the philosophy of science. Methods for calculating the positions of the…

Lovell, M.S.

2007-01-01

7

Ejs Lagrange Top Model  

NSDL National Science Digital Library

The Ejs Lagrange Top model displays the motion of a heavy symmetric top under the effect of gravity. The top has an initial angular speed that provides the precessional, nutational, and rotational speeds. The ratio of Lz to Lâ can be set via slider and the initial angular position and angular speeds can be changed via textboxes. You can modify this simulation if you have Ejs installed by right-clicking within the plot and selecting âOpen Ejs Modelâ from the pop-up menu item. Ejs Lagrange Top model was created using the Easy Java Simulations (Ejs) modeling tool. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the ejs_ehu_rigid_bodies_Lagrange.jar file will run the program if Java is installed. Ejs is a part of the Open Source Physics Project and is designed to make it easier to access, modify, and generate computer models. Additional Ejs models for rigid body dynamics are available. They can be found by searching ComPADRE for Open Source Physics, OSP, or Ejs.

Aguirregabiria, Juan

2008-08-18

8

Diana Stewart*, Christina Megalis, Y. Carol Shieh, and Mary L. Tortorello, U.S. Food and Drug Administration, 6502 S. Archer Rd., Bedford Park, IL 60501  

E-print Network

Administration, 6502 S. Archer Rd., Bedford Park, IL 60501 ABSTRACT MATERIALS & METHODS Virus Inoculation and Elution: Green onion pieces (10 g) were inoculated with either MS2 bacteriophage or tissue-culture grownH-adjusted to near neutral using NaOH or HCl, as necessary. Eluates were frozen at -20 C until RNA extracted. Amino

Heller, Barbara

9

CRAIG G. FRASER"' LAGRANGE'S ANALYTICAL MATHEMATICS,  

E-print Network

CRAIG G. FRASER"' LAGRANGE'S ANALYTICAL MATHEMATICS, ITS CARTESIAN ORIGINS AND RECEPTION IN COMTE to the mathematical methods developed in the preceding century by Euler and Lagrange. In the course of his discussion. . . . All his mathematical compositions are remarkable for a singular elegance, by the symmetry of forms

Fraser, Craig

10

Classical Lagrange Functions for the SME  

E-print Network

A technique is presented for finding the classical Lagrange function corresponding to a given dispersion relation. This allows us to study the classical analogue of the Standard-Model Extension. Developments are discussed.

Neil Russell

2010-09-07

11

International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)  

E-print Network

, fully depleted solar-cell type p-n junctions throughout these structures. This results in increased particles, which can subsequently be detected. 10 B was chosen as the conversion material due, and the ability of the charged particles resulting from neutron interaction in the absorption layer to escape

Danon, Yaron

12

Advances in Nuclear Fuel Management IV (ANFM 2009) Hilton Head Island, South Carolina, USA, April 12-15, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)  

E-print Network

- France merle@lpsc.in2p3.fr Keywords: Molten Salt Reactor, Thorium fuel cycle, fast neutron spectrum concept that we called the Thorium Molten Salt Reactor (TMSR), which is particularly well suited to fulfil "non-moderated Thorium Molten Salt Reactor" or TMSR-NM. With a fuel salt content low in light elements

Paris-Sud XI, Université de

13

Three-dimensional, Free-Lagrange hydrodynamics  

SciTech Connect

This paper describes the algorithms that make up a 3-D version of the Free-Lagrange Method. The basic method involves the explicit integration of the fluid flow equations over control volumes formed by Voronoi cells. A Voronoi cell is an arbitrary, convex polyhedron that has plane polygon faces. The ''nearest'' neighbors of any given mass point are identified by noting the mass point that lies on the opposite side of a given Voronoi face. The nearest neighbors of a mass point are allowed to change in response to the (Lagrange) motion of the mass points. This implies that the mesh reorganizes itself as the mass points move with the fluid motion.

Trease, H.

1987-01-01

14

An Extension of Lagrange's Identity to Matrices. Classroom Notes  

ERIC Educational Resources Information Center

In this note the well-known Lagrange identity is extended to matrices. The resulting generalized Lagrange identity is used to give characterizations of symmetry, commutativity of projectors and normality.

Trenkler, Gotz

2004-01-01

15

Lagrange-mesh calculations and Fourier transform  

SciTech Connect

The Lagrange-mesh method is a very accurate procedure for computing eigenvalues and eigenfunctions of a two-body quantum equation written in the configuration space. Using a Gauss quadrature rule, the method only requires the evaluation of the potential at some mesh points. The eigenfunctions are expanded in terms of regularized Lagrange functions, which vanish at all mesh points except one. Using the peculiarities of the method, it is shown that the Fourier transform of the eigenfunctions, computed in the configuration space, can easily be obtained with good accuracy in the physical domain of the momentum space. Also, observables in this space can easily be computed with good accuracy only using matrix elements and eigenfunctions computed in the configuration space.

Lacroix, Gwendolyn; Semay, Claude [Service de Physique Nucleaire et Subnucleaire, Universite de Mons-UMONS, Academie universitaire Wallonie-Bruxelles, Place du Parc 20, B-7000 Mons (Belgium)

2011-09-15

16

Invariant Euler-Lagrange Equations and the Invariant Variational Bicomplex  

E-print Network

Invariant Euler-Lagrange Equations and the Invariant Variational Bicomplex Irina A. Kogan://www.math.umn.edu/olver Abstract. In this paper, we derive an explicit group-invariant formula for the Euler- Lagrange equations associated with an invariant variational problem. The method relies on a group-invariant version

Kogan, Irina

17

Invariant Euler-Lagrange Equations and the Invariant Variational Bicomplex  

E-print Network

Invariant Euler-Lagrange Equations and the Invariant Variational Bicomplex Irina A. Kogan://www.math.umn.edu/#24;olver Abstract. In this paper, we derive an explicit group-invariant formula for the Euler- Lagrange equations associated with an invariant variational problem. The method relies on a group-invariant

18

Why is the Lagrange multiplier same as the Shadow Price?  

E-print Network

Why is the Lagrange multiplier same as the Shadow Price? Optimization Course - Summer 2008, . . . , xn) but also a corresponding value ^ for the Lagrange mul- tiplier , which is precisely the shadow price, that is the price one would afford to pay for increasing the capacity of the production by one

Cascaval, Radu C.

19

Car Park 31 Car Park 23  

E-print Network

Car Park 31 CarPark30 Car Park 1 Car Park 2 Car Park 23 Car Park 20 CarPark19 Car Park 29 Car Park 17 Car Park 16 Car Park 3 CarPark35 CarPark15 Car Park 14 Car Park 9 Car Park 33 CarPark6 CarPark5 Car Park 18 Car Park 10 Car Park 7 CaCa 8rkCCCCC PaPa kkCaCarrr P Car Park 8 Car Park 8 CarPark 21 Car

Tobar, Michael

20

Efficient semidefinite spectral clustering via lagrange duality.  

PubMed

We propose an efficient approach to semidefinite spectral clustering (SSC), which addresses the Frobenius normalization with the positive semidefinite (p.s.d.) constraint for spectral clustering. Compared with the original Frobenius norm approximation-based algorithm, the proposed algorithm can more accurately find the closest doubly stochastic approximation to the affinity matrix by considering the p.s.d. constraint. In this paper, SSC is formulated as a semidefinite programming (SDP) problem. In order to solve the high computational complexity of SDP, we present a dual algorithm based on the Lagrange dual formalization. Two versions of the proposed algorithm are proffered: one with less memory usage and the other with faster convergence rate. The proposed algorithm has much lower time complexity than that of the standard interior-point-based SDP solvers. Experimental results on both the UCI data sets and real-world image data sets demonstrate that: 1) compared with the state-of-the-art spectral clustering methods, the proposed algorithm achieves better clustering performance and 2) our algorithm is much more efficient and can solve larger-scale SSC problems than those standard interior-point SDP solvers. PMID:24951690

Yan, Yan; Shen, Chunhua; Wang, Hanzi

2014-08-01

21

LAGRANGE: LAser GRavitational-wave ANtenna at GEo-lunar Lagrange points  

E-print Network

We describe a new space gravitational wave observatory design called LAGRANGE that maintains all important LISA science at about half the cost and with reduced technical risk. It consists of three drag-free spacecraft in the most stable geocentric formation, the Earth-Moon L3, L4, and L5 Lagrange points. Fixed antennas allow continuous contact with the Earth, solving the problem of communications bandwidth and latency. A 70 mm diameter AuPt sphere with a 35 mm gap to its enclosure serves as a single inertial reference per spacecraft, which is operated in "true" drag-free mode (no test mass forcing). This is the core of the Modular Gravitational Reference Sensor whose other advantages are: a simple caging design based on the DISCOS 1972 drag-free mission, an all optical read-out with pm fine and nm coarse sensors, and the extensive technology heritage from the Honeywell gyroscopes, and the DISCOS and Gravity Probe B drag-free sensors. An Interferometric Measurement System, designed with reflective optics and a highly stabilized frequency standard, performs the inter-test mass ranging and requires a single optical bench with one laser per spacecraft. Two 20 cm diameter telescopes per spacecraft, each with in-field pointing, incorporate novel technology developed for advanced optical systems by Lockheed Martin, who also designed the spacecraft based on a multi-flight proven bus structure. Additional technological advancements include the drag-free propulsion, thermal control, charge management systems, and materials. LAGRANGE sub-systems are designed to be scalable and modular, making them interchangeable with those of LISA or other gravitational science missions. We plan to space qualify critical technologies on small and nano satellite flights, with the first launch (UV-LED Sat) in 2013.

J. W. Conklin; S. Buchman; V. Aguero; A. Alfauwaz; A. Aljadaan; M. Almajed; H. Altwaijry; T. Al-Saud; K. Balakrishnan; R. L. Byer; K. Bower; B. Costello; G. D. Cutler; D. B. DeBra; D. M. Faied; C. Foster; A. L. Genova; J. Hanson; K. Hooper; E. Hultgren; B. Jaroux; A. Klavins; B. Lantz; J. A. Lipa; A. Palmer; B. Plante; H. S. Sanchez; S. Saraf; D. Schaechter; T. Sherrill; K. -L. Shu; E. Smith; D. Tenerelli; R. Vanbezooijen; G. Vasudevan; S. D. Williams; S. P. Worden; J. Zhou; A. Zoellner

2011-11-22

22

General Relativity as a fully singular Lagrange system  

E-print Network

We present some gauge conditions to eliminate all second time derivative terms in the vierbein forms of the ten Einstein equations of general relativity; at the same time, we present the corresponding Lagrangian in which there is not any quadratic term of first time derivative that can leads to those vierbein forms of the Einstein equations without second time derivative term by the corresponding Euler-Lagrange equations. General relativity thus becomes a fully singular Lagrange system.

T. Mei

2010-03-28

23

ParkingEducation Week Parking DisabledParking  

E-print Network

for Classes Ed. Week Parking Van Routes Dining Areas Housing Areas Van Stops Direct Shuttles (West StadiumSAB IPF Education Week ParkingEducation Week Parking Education Week Parking Education Week Parking Disabled Parking DisabledParking Education Week Parking BYU Faculty/StaffParking Parking 900 NORTH 900EAST

Hart, Gus

24

On the attraction of Newton's method to critical lagrange multipliers  

NASA Astrophysics Data System (ADS)

The attraction of dual trajectories of Newton's method for the Lagrange system to critical Lagrange multipliers is analyzed. This stable effect, which has been confirmed by numerical practice, leads to the Newton-Lagrange method losing its superlinear convergence when applied to problems with irregular constraints. At the same time, available theoretical results are of "negative" character; i.e., they show that convergence to a noncritical multiplier is not possible or unlikely. In the case of a purely quadratic problem with a single constraint, a "positive" result is proved for the first time demonstrating that the critical multipliers are attractors for the dual trajectories. Additionally, the influence exerted by the attraction to critical multipliers on the convergence rate of direct and dual trajectories is characterized.

Uskov, E. I.

2013-08-01

25

Visitor Parking Parking Legend  

E-print Network

(Emergency Phones) Z2 A B Z1 Z R1 S1 S2 S R2 C Need supplemental decal to park T1 D E T J H G F Q B C M N P Manchester Athletic Center 19A Pruitt Football Center 20 Calloway Center 20A Manchester Hall 20B Kirby Hall

Erway, Jennifer

26

IL-12/IL-23 Salmonella  

E-print Network

Keywords Immunity IL-12/IL-23 Salmonella Cryptococcus » Prof. Dr. Gottfried Alber Interleukin.; Kastelein, r. a.; alBer, G. Protective immunity to systemic infection with attenuated Salmonella enterica se

Schüler, Axel

27

Permit Parking Metered Parking  

E-print Network

& Ancillary Services, DalCard Office C720 European Studies C730 APICS, Science Co-op C750 Transition Year Parking for people with disabilities Emergency "Code Blue" Phone B120 B120B120 B120 E280E280 E200 C382C382 Student Residence D400 Arts Centre, Cohn Auditorium D420 Marion McCain Arts and Social Sciences Building D

Selinger, Peter

28

TwilightTwilight phenomenaphenomena of Venusof Venus Laboratoire Lagrange  

E-print Network

TwilightTwilight phenomenaphenomena of Venusof Venus P. Tanga Laboratoire Lagrange Observatoire de ­ Paris, March 6 2012 #12;Paolo Tanga ­The aureole of Venus Sakura/Europlanet Workshop ­ Paris, March 6°.5 Phase angle 177° Mallama et al. 2006 #12;Paolo Tanga ­The aureole of Venus Sakura/Europlanet Workshop

Widemann, Thomas

29

Power system design optimization using Lagrange multiplier techniques  

NASA Astrophysics Data System (ADS)

An optimization technique using the Lagrange Multiplier Method is proposed to facilitate design of switching power converter systems. The essence of the optimization is to identify the optimal battery voltage level and switching frequency along with the detailed converter design so that the total system weight including the battery and the packaged converter is minimized, and concurrently all specified power circuit performances are satisfied.

Yu, Y.; Lee, F. C.

1981-09-01

30

ORCHIVE: Digitizing and Analyzing Orca Vocalizations George Tzanetakis & Mathieu Lagrange  

E-print Network

ORCHIVE: Digitizing and Analyzing Orca Vocalizations George Tzanetakis & Mathieu Lagrange digital archive of killer whale or orca vocalizations. The goal of the project is to digitize of the acoustic communications of Orca communities worldwide. Introduction The fish eating killer whales or orcas

Tzanetakis, George

31

On the Microwave Signal at the Second Lagrange Point  

Microsoft Academic Search

It has been proposed that the 2.7 K Penzias-Wilson monopole is of oceanic origin. Under this scenario, the signal should be powerful near the Earth and rapidly fall in power away from our planet. As a result, the Penzias and Wilson signal is not expected to have any significant intensity at the second Lagrange point. In July 2008, the ESA

Pierre-Marie Robitaille; Larissa Borissova; Dmitri Rabounski

2007-01-01

32

Stochastic Asymmetry Properties of 3D Gauss-Lagrange Ocean Waves with Directional Spreading  

Microsoft Academic Search

In the stochastic Lagrange model for ocean waves the vertical and horizontal location of surface water particles are modeled as correlated Gaussian processes. In this article we investigate the statistical properties of wave characteristics related to wave asymmetry in the 3D Lagrange model. We present a modification of the original Lagrange model that can produce front-back asymmetry both of the

Georg Lindgren; Finn Lindgren

2011-01-01

33

Kentucky Clinic Parking Parking Garage  

E-print Network

Cancer Center Hospital Parking Garage & Shuttle Veterans Affairs Medical Center College of Pharmacy ConcourseBridge oneway Exit only Kentucky Children's Hospital HUGUELETDR. WASHINGTONAVE. SOUTH LIMESTONE UK Chandler Hospital Short-term Patient Parking two way #12;

Hayes, Jane E.

34

Parking Regulations PARKING POLICY STATEMENT  

E-print Network

is restricted to those with college lot decals 24 hours a day, 7 days a week during the academic year, except who park on campus are required to register their motor vehicles with the Rice Parking Office or park and reserved for the primary use of the residents of these neighborhoods and their visitors. When visiting

Richards-Kortum, Rebecca

35

Accurate solution of the Dirac equation on Lagrange meshes.  

PubMed

The Lagrange-mesh method is an approximate variational method taking the form of equations on a grid because of the use of a Gauss quadrature approximation. With a basis of Lagrange functions involving associated Laguerre polynomials related to the Gauss quadrature, the method is applied to the Dirac equation. The potential may possess a 1/r singularity. For hydrogenic atoms, numerically exact energies and wave functions are obtained with small numbers n+1 of mesh points, where n is the principal quantum number. Numerically exact mean values of powers -2 to 3 of the radial coordinate r can also be obtained with n+2 mesh points. For the Yukawa potential, a 15-digit agreement with benchmark energies of the literature is obtained with 50 or fewer mesh points. PMID:24827362

Baye, Daniel; Filippin, Livio; Godefroid, Michel

2014-04-01

36

Covariant Lagrange multiplier constrained higher derivative gravity with scalar projectors  

E-print Network

We formulate higher derivative gravity with Lagrange multiplier constraint and scalar projectors. Its gauge-fixed formulation as well as vector fields formulation is developed and corresponding spontaneous Lorentz symmetry breaking is investigated. We show that the only propagating mode is higher derivative graviton while scalar and vector modes do not propagate. Despite to higher derivatives structure of the action, its first FRW equation is the first order differential equation which admits the inflationary universe solution.

Josef Kluson; Shin'ichi Nojiri; Sergei D. Odintsov

2011-04-21

37

Central Park  

NSDL National Science Digital Library

As one of the worldâÂÂs greatest urban green spaces, Central Park is loved by dyed-in-the wool New Yorkers as well as visitors to the city. This reverential website provides detailed information about this fine public space and the activities that take place within its confines. On this site, visitors can look over maps of the park, learn about the parkâÂÂs many attractions, and browse a selection of photographs of this fine urban paradise. The homepage contains much of this material, along with a âÂÂCentral Park Newsâ feature, which provides news updates about goings on throughout Central Park. For those planning a visit to the park, the Events area will be most useful, as it provides information about such pastimes as rock climbing, ice skating lessons, and yoga.

2006-01-01

38

National Parks  

NSDL National Science Digital Library

This online directory focuses on national parks throughout the country that offer educational opportunities. Where possible, it includes the following information for each: the type of support offered, including educational materials, access to a naturalist or specialists, and classes/workshops; and mailing address and contact information. In addition, a link to the National Park Service's Web site is included.

39

Prospect Park  

NSDL National Science Digital Library

While many readers may be aware that trees grow in Brooklyn, few may be cognizant of the fact that, yes, a forest grows in Brooklyn. This urban forest just happens to be in the boroughâÂÂs own lovely Prospect Park, designed by those giants of landscape architects, Frederick Law Olmsted and Calvert Vaux. Often overlooked by some who are primarily concerned with that other large swath of green in the middle of Manhattan, Prospect Park contains a 90-acre meadow, a zoo, a celebrated performing arts festival, and a lake. Visitors to the Prospect Park Alliance website can learn all about these things, and also delve into the parkâÂÂs history. Those planning a visit may wish to look at the âÂÂGeneral Infoâ and âÂÂPlaces To Goâ sections for a selection of brief descriptions and photographs. For those seeking a historical perspective the âÂÂHistory & Natureâ area is delightful. Here visitors can learn about the parkâÂÂs historical development and creation, and learn more about those individuals responsible for the parkâÂÂs design and aesthetic appeal. Finally, visitors should look at the online exhibit âÂÂA Glimpse Of Prospect Parkâ for a bit of visual perspective on the parkâÂÂs history.

Prospect Park (New York, N.Y.)

40

Park It!  

ERIC Educational Resources Information Center

Many artists visit national parks to draw, paint and take photographs of some of the most amazing scenery on earth. Raw nature is one of the greatest inspirations to an artist, and artists can be credited for helping inspire the government to create the National Park System. This article features Thomas Moran (1837-1926), one of the artists who…

Sartorius, Tara Cady

2010-01-01

41

Minimum fuel trajectories for a low-thrust power-limited mission to the moon and to Lagrange points L4 and L5  

NASA Astrophysics Data System (ADS)

Minimum fuel trajectories from a low earth parking orbit to Lagrange points L4 or L5 and to the moon are obtained for a low-thrust limited-power spacecraft, with thrust acceleration levels of the order of 0.001 G. The procedure to find a trajectory to the libration point starts from an analytical description of a slightly elliptical spiral, given by Breakwell and Rauch. The earth moon trajectory is found by matching an earth spiral to a moon spiral on the sphere of influence. Earth oblateness effect is considered.

Breakwell, John V.; Golan, Oded M.

42

Free Parking David Tarboton  

E-print Network

ENG STL STL STANLAUBPRACTICE FACILITY 1 2 2 BBT 3 3 4 Student Parking Areas BLUE permit holders may park in any Blue or Yellow parking area. YELLOW permit holders may park in any Yellow parking area area. Misc. Parking Areas PUBLIC PAY PARKING Rates are posted at each site. STATE VEHICLE PARKING 1

Tarboton, David

43

16QAM Blind Equalization via Maximum Entropy Density Approximation Technique and Nonlinear Lagrange Multipliers  

PubMed Central

Recently a new blind equalization method was proposed for the 16QAM constellation input inspired by the maximum entropy density approximation technique with improved equalization performance compared to the maximum entropy approach, Godard's algorithm, and others. In addition, an approximated expression for the minimum mean square error (MSE) was obtained. The idea was to find those Lagrange multipliers that bring the approximated MSE to minimum. Since the derivation of the obtained MSE with respect to the Lagrange multipliers leads to a nonlinear equation for the Lagrange multipliers, the part in the MSE expression that caused the nonlinearity in the equation for the Lagrange multipliers was ignored. Thus, the obtained Lagrange multipliers were not those Lagrange multipliers that bring the approximated MSE to minimum. In this paper, we derive a new set of Lagrange multipliers based on the nonlinear expression for the Lagrange multipliers obtained from minimizing the approximated MSE with respect to the Lagrange multipliers. Simulation results indicate that for the high signal to noise ratio (SNR) case, a faster convergence rate is obtained for a channel causing a high initial intersymbol interference (ISI) while the same equalization performance is obtained for an easy channel (initial ISI low). PMID:24723813

Mauda, R.; Pinchas, M.

2014-01-01

44

@central park  

NSDL National Science Digital Library

The Central Park Conservancy, a not-for-profit organization dedicated to restoring, improving, and managing Central Park's grounds and facilities, offers this "official" site, which contains a wealth of information about what is arguably the world's most famous city park. Each of the site's sections contains useful or interesting information; the Then & Now section, for instance, offers an overview of Central Park's history, a bibliography with 43 entries for those seeking further information, and a list of movies with scenes set in the park. Another highlight of the site is the Virtual Park, which consists of a set of clickable maps through which users can explore 72 points of interest, each described in the affectionate style of a travel guidebook. The site's other sections include such features as events schedules, press releases, information on when and where particular varieties of flowers bloom, and a section devoted entirely to activities for families and children. This site will be especially useful to those who are planning a visit to Central Park, but other users will likely find it informative and entertaining as well.

45

Parks Canada  

NSDL National Science Digital Library

The national park system of Canada is extensive, stretching from Baffin Island to areas in British Columbia. The stated goal of the system is "to establish a system of national parks that represents each of Canada's distinct natural regions." First-time visitors to the site can use the Introduction area to learn more about the system, and there's also a Planning Your Visit link that's quite helpful. The basic document that most users will want to check out here is titled "National Parks System Plan" and it offers a broad overview of the 39 national parks in Canada. Visitors can learn about parks such as Aulavik, Prince Edward Island, and others by clicking over to the Find a National Park area. Naturalists and scientists can use the Species at Risk area to learn about what the Canadian government is doing to protect species such as the whooping crane and the seaside centipede lichen. Finally, the site is rounded out by the Managing Human Use link which talks about their long-range plans to ensure that the parks maintain a balance between visitors and conserving the natural areas.

2008-10-27

46

Energetic Order for Optimization on Hierarchies of Partitions Continuous hierarchy and Lagrange optimization  

E-print Network

theory for optimizing the cuts in a hierarchy of partitions of the space, and study in particular the Lagrange type methods. The need for such hierarchies appears frequently in image processing, whereEnergetic Order for Optimization on Hierarchies of Partitions Continuous hierarchy and Lagrange

Boyer, Edmond

47

Lagrange constraint neural network for audio varying BSS  

NASA Astrophysics Data System (ADS)

Lagrange Constraint Neural Network (LCNN) is a statistical-mechanical ab-initio model without assuming the artificial neural network (ANN) model at all but derived it from the first principle of Hamilton and Lagrange Methodology: H(S,A)= f(S)- (lambda) C(s,A(x,t)) that incorporates measurement constraint C(S,A(x,t))= (lambda) ([A]S-X)+((lambda) 0-1)((Sigma) isi -1) using the vector Lagrange multiplier-(lambda) and a- priori Shannon Entropy f(S) = -(Sigma) i si log si as the Contrast function of unknown number of independent sources si. Szu et al. have first solved in 1997 the general Blind Source Separation (BSS) problem for spatial-temporal varying mixing matrix for the real world remote sensing where a large pixel footprint implies the mixing matrix [A(x,t)] necessarily fill with diurnal and seasonal variations. Because the ground truth is difficult to be ascertained in the remote sensing, we have thus illustrated in this paper, each step of the LCNN algorithm for the simulated spatial-temporal varying BSS in speech, music audio mixing. We review and compare LCNN with other popular a-posteriori Maximum Entropy methodologies defined by ANN weight matrix-[W] sigmoid-(sigma) post processing H(Y=(sigma) ([W]X)) by Bell-Sejnowski, Amari and Oja (BSAO) called Independent Component Analysis (ICA). Both are mirror symmetric of the MaxEnt methodologies and work for a constant unknown mixing matrix [A], but the major difference is whether the ensemble average is taken at neighborhood pixel data X's in BASO or at the a priori sources S variables in LCNN that dictates which method works for spatial-temporal varying [A(x,t)] that would not allow the neighborhood pixel average. We expected the success of sharper de-mixing by the LCNN method in terms of a controlled ground truth experiment in the simulation of variant mixture of two music of similar Kurtosis (15 seconds composed of Saint-Saens Swan and Rachmaninov cello concerto).

Szu, Harold H.; Hsu, Charles C.

2002-03-01

48

Alaska Park Science National Park Service  

E-print Network

Alaska Park Science National Park Service Alaska Support Office 2525 Gambell Street Anchorage, Alaska 99503-2892 PhotographcourtesyofAlutiiqMuseumandHeritageCenter NationalParkServicephotograph #12;Alaska Park Science Connections to Natural and Cultural Resource Studies in Alaska's National Parks

49

Car Parking and Access Car Parking  

E-print Network

Car Parking and Access Car Parking Parking permits are provided free of charge for visitors of the car parks on campus for the duration of the conference. The number of available spaces, and the location, will depend on demand for car parking for University business on any given date. Unfortunately

Sussex, University of

50

A Lagrange multiplier based divide and conquer finite element algorithm  

NASA Technical Reports Server (NTRS)

A novel domain decomposition method based on a hybrid variational principle is presented. Prior to any computation, a given finite element mesh is torn into a set of totally disconnected submeshes. First, an incomplete solution is computed in each subdomain. Next, the compatibility of the displacement field at the interface nodes is enforced via discrete, polynomial and/or piecewise polynomial Lagrange multipliers. In the static case, each floating subdomain induces a local singularity that is resolved very efficiently. The interface problem associated with this domain decomposition method is, in general, indefinite and of variable size. A dedicated conjugate projected gradient algorithm is developed for solving the latter problem when it is not feasible to explicitly assemble the interface operator. When implemented on local memory multiprocessors, the proposed methodology requires less interprocessor communication than the classical method of substructuring. It is also suitable for parallel/vector computers with shared memory and compares favorably with factorization based parallel direct methods.

Farhat, C.

1991-01-01

51

75 FR 52013 - Notice of Intent to Repatriate Cultural Items: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Cultural Items: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History (Field Museum), Chicago, IL, that...OR, for the Field Museum of Natural History. The items were accessioned into...

2010-08-24

52

Menomonee River Norris Park  

E-print Network

College of Communication 8 Krueger Child Care Center 37 Lalumiere Language 21 Raynor Library 20 Parking Structures 16th Street Parking Structure 55 18th Street Parking Structure 43 Eckstein Hall Parking 7a, 7b Wells

Reid, Scott A.

53

Staff Parking Crewe Green  

E-print Network

the petrol station and cross Macon Way. Walk down Crewe Green Road past the fire station and the Crewe campus Green Road A534Crewe Railway Station 1 2 3 4 5 6 7 8 10 1112 13 14 15 16 17 9 18 Manchester Metropolitan Parking Staff Parking Parking Parking Visitor Parking Parking Crewe Green Road A534Crewe Railway Station

54

Park Smart  

NASA Technical Reports Server (NTRS)

The Parking Garage Automation System (PGAS) is based on a technology developed by a NASA-sponsored project called Robot sensorSkin(TM). Merritt Systems, Inc., of Orlando, Florida, teamed up with NASA to improve robots working with critical flight hardware at Kennedy Space Center in Florida. The system, containing smart sensor modules and flexible printed circuit board skin, help robots to steer clear of obstacles using a proximity sensing system. Advancements in the sensor designs are being applied to various commercial applications, including the PGAS. The system includes a smartSensor(TM) network installed around and within public parking garages to autonomously guide motorists to open facilities, and once within, to free parking spaces. The sensors use non-invasive reflective-ultrasonic technology for high accuracy, high reliability, and low maintenance. The system is remotely programmable: it can be tuned to site-specific requirements, has variable range capability, and allows remote configuration, monitoring, and diagnostics. The sensors are immune to interference from metallic construction materials, such as rebar and steel beams. Inside the garage, smart routing signs mounted overhead or on poles in front of each row of parking spots guide the motorist precisely to free spaces.

1999-01-01

55

What Did We Think Could Be Learned About Earth From Lagrange Point Observations?  

NASA Technical Reports Server (NTRS)

The scientific excitement surrounding the NASA Lagrange point mission Triana, now called DSCOVR, tended to be forgotten in the brouhaha over other aspects of the mission. Yet a small band of scientists in 1998 got very excited about the possibilities offered by the Lagrange-point perspective on our planet. As one of the original co-investigators on the Triana mission, I witnessed that scientific excitement firsthand. I will bring to life the early period, circa 1998 to 2000, and share the reasons that we thought the Lagrange-point perspective on Earth would be scientifically revolutionary.

Wiscombe, Warren

2011-01-01

56

Interferometric Characterization of the Earth's Atmosphere from Lagrange Point 2  

NASA Technical Reports Server (NTRS)

Part of the NASA plans for future Earth Science missions calls for observations using novel vantage points that can produce science products otherwise unobtainable. Observations of the Earth from the Lagrange-2 point, L-2, (1.5 million km behind the Earth on the Earth-Sun line) affords a unique vantage point for atmospheric science. Spectral observation of the Earth's atmosphere using solar occultation techniques in the near infrared (1 to 4 microns) provides one of the most accurate methods of passively sensing attitude profiles of the major species (CO2, O3, O2, CH4, H2O N2O). While traditional polar orbiting occultation measurements can obtain about 14 measurements per day (2 per orbit), solar occultation observations from the Lagrange-2 point will yield hourly profile measurements at all latitudes. The expected spatial resolution is 2 km in altitude, 0.5 degrees in latitude, and 2 degrees in longitude. The result from 24 hours of observations will be a three-dimensional map of atmospheric composition. To accomplish this task from L-2 requires the development of a large moderate spectral resolution instrument whose entrance aperture is about 10 meters. Use of a standard telescope design with a 10-meter circular mirror or a 10-meter strip mirror would be prohibitively expensive and excessively massive. Instead, we are proposing the development of a 10-meter linear interferometer coupled to a Fourier transform imaging spectrometer. The result will be a highly efficient design with sufficient sensitivity, while having both spatial and spectral resolution to produce the desired results. Preliminary calculations show that seven species (CO2, O3, O2, CH4, H2O N2O) have clearly separated spectral features in the I to 4 microns range with sufficient absorption to produce profile information from near the Earth's surface to the middle stratosphere. For CO2 the estimated sensitivity to change is 0.33% or 1 part in 330. This should be sufficient to detect changes that are significant for the carbon cycle studies. Initial instrument design studies are underway to determine the optimum optical design for the interferometer-spectrometer as well as the necessary highly stable mechanical designs. Separate design studies are being conducted for the spacecraft. shuttle launch facility, low-light solar power design, thermal control, and unique navigation requirements to reach and maintain the tight halo orbit about L-2.

Herman, Jay R.; Komar, George (Technical Monitor)

2001-01-01

57

Motorcycle and Moped Parking Map Moped Parking Only  

E-print Network

parking spaces. Motorcycles and Mopeds may also park in BLUE parking areas, such as the commuter parkingMotorcycle and Moped Parking Map Moped Parking Only Motorcycle and Moped Parking All motorcycles and mopeds are required to have a valid UVa Parking Permit to park in designated motorcycle and/or moped

Acton, Scott

58

Theodore Roosevelt National Park  

NSDL National Science Digital Library

This National Park Service website contains information on: the park history; park activities such as hiking and camping; and natural history such as the wildlife, geology and paleontology of the park. The kids' section contains coloring pages, a park trivia quiz, reference sections on the wildlife and natural history of the park, and information on Theodore Roosevelt and his involvement in the Badlands. There are also images of the wildlife and scenery of the park.

59

Centrifuge Rotor Models: A Comparison of the Euler-Lagrange and the Bond Graph Modeling Approach  

NASA Technical Reports Server (NTRS)

A viewgraph presentation on centrifuge rotor models with a comparison using Euler-Lagrange and bond graph methods is shown. The topics include: 1) Objectives; 2) MOdeling Approach Comparisons; 3) Model Structures; and 4) Application.

Granda, Jose J.; Ramakrishnan, Jayant; Nguyen, Louis H.

2006-01-01

60

Some generalized Lagrange-based Apostol-Bernoulli, Apostol-Euler and Apostol-Genocchi polynomials  

NASA Astrophysics Data System (ADS)

In this paper, we introduce a general family of Lagrange-based Apostol-type polynomials thereby unifying the Lagrange-based Apostol-Bernoulli and the Lagrange-based Apostol-Genocchi polynomials. We also define Lagrange-based Apostol-Euler polynomials via the generating function. In terms of these generalizations, we find new and useful relations between the unified family and the Apostol-Euler polynomials. We also derive their explicit representations and list some basic properties of each of them. Further relations between the above-mentioned polynomials, including a family of bilinear and bilateral generating functions, are given. Moreover, a generating relation involving the Stirling numbers of the second kind is derived.

Srivastava, H. M.; Özarslan, M. A.; Kaano?lu, C.

2013-03-01

61

PARKING OFFICER Position Information  

E-print Network

citations in parking lots, structures and the core of campus for vehicles in violation of University parking of applicable procedures and regulations related to parking and traffic control. Knowledge of campus layout and parking facilities and the ability to act and resolve parking and traffic problems. Ability to write

Ponce, V. Miguel

62

ACE Parking Workplace Education.  

ERIC Educational Resources Information Center

This manual is designed for use in a four-session workshop to help new parking garage employees enhance their skills in the following areas: understanding the functions of parking employees, computing parking rates and filling out parking lot reconciliation forms, preparing miscellaneous parking lot forms and developing effective communication and…

Sweetwater Union High School District, Chula Vista, CA.

63

Park It!  

NSDL National Science Digital Library

The difference between an architect and an engineer is sometimes confusing because their roles in building design can be similar. Students experience a bit of both professions by following a set of requirements and meeting given constraints as they create a model parking garage. They experience the engineering design process first-hand as they design, build and test their models. They draw a blueprint for their design, select the construction materials and budget their expenditures. They also test their structures for strength and find their maximum loads.

Integrated Teaching And Learning Program And Laboratory

64

National Environmental Research Parks  

SciTech Connect

The National Environmental Research Parks are outdoor laboratories that provide opportunities for environmental studies on protected lands that act as buffers around Department of Energy (DOE) facilities. The research parks are used to evaluate the environmental consequences of energy use and development as well as the strategies to mitigate these effects. They are also used to demonstrate possible environmental and land-use options. The seven parks are: Fermilab National Environmental Research Park; Hanford National Environmental Research Park; Idaho National Environmental Research Park; Los Alamos National Environmental Research Park; Nevada National Environmental Research Park; Oak Ridge National Environmental Research Park; and Savannah River National Environmental Research Park. This document gives an overview of the events that led to the creation of the research parks. Its main purpose is to summarize key points about each park, including ecological research, geological characteristics, facilities, and available databases.

Not Available

1994-07-01

65

Advice & Regulations for parking  

E-print Network

and Display areas and car parks 7, 8a, 13, and 15 Staff permits : Staff may apply for a parking permit space Not park on yellow lines or hatched areas Not park in a disabled bay without a valid disabledAdvice & Regulations for parking 2009-2010 C A M P U S PA RK I N G P L A N PARKING ZONES Pay

Davies, Christopher

66

Study on Fault Diagnosis of Rolling Bearing Based on K-L Transformation and Lagrange Support Vector Regression  

Microsoft Academic Search

On the basis of vibration signal of rolling bearing, a new method of fault diagnosis based on K-L transformation and Lagrange support vector regression is presented.Multidimensional correlated variable is transformed into low dimensional independent eigenvector by the means of K-L transformation. The pattern recognition and nonlinear regression are achieved by the method of Lagrange support vector regression. Lagrange support vector

Yangwen Xu

2009-01-01

67

Space Debris Hazards from Explosions in the collinear Sun-Earth Lagrange points  

E-print Network

The collinear Lagrange points of the Sun-Earth system provide an ideal environment for highly sensitive space science missions. Consequently many new missions are planed by ESA and NASA that require satellites close to these points. For example, the SOHO spacecraft built by ESA is already installed in the first collinear Lagrange point. Neither uncontrolled spacecraft nor escape motors will stay close to the Lagrange points for a long time. In case an operational satellite explodes, the fragmentation process will take place close to the Lagrange point. Apparently a number of spacecraft will accumulate close to the Lagrange points over the next decades. We investigate the space debris hazard posed by these spacecraft if they explode and fall back to an Earth orbit. From our simulation we find that, as expected, about half of the fragments drift towards the Earth while the other half drifts away from it. Around 2% of the simulated fragments even impact the Earth within one year after the explosion.

M. Landgraf; R. Jehn

2001-04-17

68

Grand Teton National Park  

NSDL National Science Digital Library

This National Park Service website provides a trip planner, information on natural and cultural history, publications, a park fact sheet for students, park maps, student bibliography, and a newspaper for kids. There is information on the geology, rock formations, mountain building, volcanism, and glaciation of the Teton Range. Educational resources for students and teachers consist of links to other National Park Service sites.

69

Parking Services: 2010 2011  

E-print Network

. There is always competi- tion for parking in the areas closest to campus. If you need to bring your vehicleRegional Map: Parking Services: 2010 ­ 2011 Kent State University Traffic on campus is heavy on campus... Non-visitors must purchase and display a valid parking permit obtained through Parking Services

Khan, Javed I.

70

Parking Fees Thefollowingfeesapplyfortherampgarage  

E-print Network

the visitor parking areas. 30-Day Pass 30-Day Passes are available for those in need. A letter fromParking Fees Thefollowingfeesapplyfortherampgarage and for all visitor lots: 0-30 Minutes Free 31 or misplaced parking tickets. How to pay for parking Takeyour entry ticket withyouwhen entering the hospital

Portman, Douglas

71

Access into Campus & Parking  

E-print Network

to the public: Beck LDC Parking Lots Phased Construction - Select areas open to the public: Joyce Kilmer CampusLSC Lot 105 Phase A Access into Campus & Parking Scarlet Lot RAC Livingston Campus Construction into Parking & Day Care From Road 3 Access to Parking Only No Thru Access to Campus Foot path is available

72

Parking and Transport Policy Page 1 Parking and Transport Policy  

E-print Network

;Parking and Transport Policy Page 2 Pay-As-You-Go parking Parking provided in designated parking areas where a fee is payable based on the use of the parking. These areas are available to staff, studentsParking and Transport Policy Page 1 Parking and Transport Policy Category: Facilities, Campus Life

73

Glacier National Park  

NSDL National Science Digital Library

This is the homepage of Glacier National Park. Users can access materials on the park's ecology and environment (plants and animals, biodiversity and air quality, geology, and fires), the culture and history of the park, park activities, and publications on naturalist activities. There are also video clips of park wildlife and scenery, a photo gallery, and live webcams. Links are provided to additional information, such as research activities on bear DNA and global climate change.

74

From the starting Lagrange density to the e#ective fields for spinors in the Approach unifying spins and charges  

E-print Network

From the starting Lagrange density to the e#ective fields for spinors in the Approach unifying density in d (= 1 + 13) for spinors is presented, leading in d = (1 + 3) to observable families of quarks and the corresponding Higgs mechanism. Start­ ing with a simple Lagrange density for spinors, which carry in d = 1

75

Urban Parks: Constraints on Park Visitation  

E-print Network

URBAN PARKS: Constraints on Park Visitation E-430 12/06 David Scott* leisure activities are unlikely to participate in such activities or to visit parks. Some constraints are interpersonal in nature. Studies have shown that members of ethnic... understand that they are in competition for people?s free time (Scott). Constraints to Beginning and Continuing Leisure Activities Various constraints may be more or less important depending on whether the goal is to explain why people stop participating...

Scott, David

2006-12-19

76

Park Geology: Tour of National Parks  

NSDL National Science Digital Library

A great site from the National Park Service, Geologic Resources Division provides information on geologic features of our national parks. The site is aimed at a young audience (K-8), but is a pleasure to browse for anyone. Organizing the site by geologic features (e.g., Hot Springs, Oldest Rocks, and Volcanoes) allows readers to compare the geology of various national parks and explore maps, photos and other related links.

77

Acadia National Park: Teachers  

NSDL National Science Digital Library

This National Park Service website contains information on: saving the habitats of peregrine falcons; the water cycle; becoming a junior ranger; and ranger-led school programs, which contain student field activities about the history, biology and geology of the park. Teacher resources include information on a library for educators at the visitor center of the park and teacher guides for preparing to visit the park. The kids' section explains what rangers do, gives tips on leaving no trace in the park, provides a history of Mount Desert Island, and contains an activity to match some park animals to their habitats.

78

Field theory and weak Euler-Lagrange equation for classical particle-field systems  

NASA Astrophysics Data System (ADS)

It is commonly believed as a fundamental principle that energy-momentum conservation of a physical system is the result of space-time symmetry. However, for classical particle-field systems, e.g., charged particles interacting through self-consistent electromagnetic or electrostatic fields, such a connection has only been cautiously suggested. It has not been formally established. The difficulty is due to the fact that the dynamics of particles and the electromagnetic fields reside on different manifolds. We show how to overcome this difficulty and establish the connection by generalizing the Euler-Lagrange equation, the central component of a field theory, to a so-called weak form. The weak Euler-Lagrange equation induces a new type of flux, called the weak Euler-Lagrange current, which enters conservation laws. Using field theory together with the weak Euler-Lagrange equation developed here, energy-momentum conservation laws that are difficult to find otherwise can be systematically derived from the underlying space-time symmetry.

Qin, Hong; Burby, Joshua W.; Davidson, Ronald C.

2014-10-01

79

SOUND SOURCE TRACKING AND FORMATION USING NORMALIZED CUTS Mathieu Lagrange, George Tzanetakis  

E-print Network

as the summation of sine waves parameterized by time-varying amplitudes, frequencies and phases. In the classic McSOUND SOURCE TRACKING AND FORMATION USING NORMALIZED CUTS Mathieu Lagrange, George Tzanetakis computer systems that can take as input a mix- ture of sounds and form packages of acoustic evidence

Tzanetakis, George

80

A COMPARISON BETWEEN LAGRANGE MULTIPLIER AND PENALTY METHODS FOR SETTING BOUNDARY  

E-print Network

Particle Hydrodynamics (SPH) [Liu03b] method introduced to model astrophysical phen, Método de Multiplicadores de Lagrange. Abstract-- A simulation of a cantilever beam was carried out to more complex simulations that cannot be well approximated by the boundary conditions scheme. #12

Alberta, University of

81

Enhanced merit order and augmented Lagrange Hopfield network for hydrothermal scheduling  

Microsoft Academic Search

This paper proposes an enhanced merit order (EMO) and augmented Lagrange Hopfield network (ALHN) for solving hydrothermal scheduling (HTS) problem with pumped-storage units. EMO is a merit order enhanced by heuristic search based algorithms and the ALHN is a continuous Hopfield network with its energy function based on augmented Lagrangian function. EMO is efficient in unit scheduling, whereas ALHN can

Vo Ngoc Dieu; Weerakorn Ongsakul

2008-01-01

82

75 FR 52022 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History, Chicago, IL. The human remains and...remains was made by Field Museum of Natural History professional staff in consultation...

2010-08-24

83

75 FR 438 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History, Chicago, IL. The human remains were...remains was made by Field Museum of Natural History professional staff in consultation...

2010-01-05

84

75 FR 435 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History, Chicago, IL. The human remains were...remains was made by Field Museum of Natural History professional staff in consultation...

2010-01-05

85

Carlsbad Caverns National Park  

NSDL National Science Digital Library

This National Park Service (NPS) website contains details about Carlsbad Caverns National Park in New Mexico. It highlights the natural resources of the park, such as the wilderness, wildlife and caves. The geologic history and formation of caves is covered in detail. There is a teacher's guide with activities, field trip ideas, and factsheets about the park. Topics covered include rocks, erosion, speleothems, mapping caves, fossils, plants and animals, cave bats and fire. Links are provided for more information.

86

Parks In Partnership.  

ERIC Educational Resources Information Center

More than 50 National Park Service (NPS) sites interpret Native cultures or early Native contact with Europeans. In about 30 of those, American Indians, Alaska Natives, or Native Hawaiians, in partnership with the NPS, present their own heritage and issues. Describes Native-run aspects of Sitka National Historical Park, Glacier National Park, and…

Bowman, Sally-Jo

1998-01-01

87

Parking 2.0  

Microsoft Academic Search

A host of new smart parking technologies are helping municipalities meet their twin aims of collecting revenue for city services and preventing a small number of cars from monopolizing a limited number of parking slots. These advances are also benefiting motorists by making the tasks of finding a space and paying to park less of a hassle. Some examples include

Willie D. Jones

2006-01-01

88

Name That Park  

NSDL National Science Digital Library

In this online interactive, learners are introduced to the basic function of Geographic Information System (GIS) maps in relation to national parks. Recognizable park boundaries are presented and learners are given the option to add layers such as lakes, rivers and visitor centers, until the learner is able to identify the park map from a list of choices.

Service, National P.

2013-05-15

89

PARKiNG iNfoRmAtioN CAMPUS PARkING LOTS and ARRANGEMENTS ______________________________________  

E-print Network

. All other areas except Visitor spaces require that the appropriate parking permit be obtained observe the same traffic rules as 4-wheel vehicles. There are special cycle parking areas in each parking26 PARKiNG iNfoRmAtioN CAMPUS PARkING LOTS and ARRANGEMENTS

Hemmers, Oliver

90

Guadalupe Mountains National Park  

NSDL National Science Digital Library

This National Park Service website offers information on: planning a visit to the park; natural resources such as the geology, wildlife, plants, and wildland fires of the park; cultural history including that of the Mescalero Apaches and the Buffalo Soldiers; and park management issues. A description of the Permian geology of the park includes the rock exposures (composed of reef, back-reef, fore-reef, and basin sediments) which form the ancient fossil reef known as the Capitan Reef of the ancient Delaware Sea.

91

Capitol Reef National Park  

NSDL National Science Digital Library

This National Park Service (NPS) website provides an in-depth look at Capitol Reef National Park in Utah. Specifically, this covers the geology and natural resources of the park. There is a general overview of the geology of this area including the Waterpocket fold, Colorado Plateau, Cathedral Valley and erosion. There is a description of various rock colors and how they form, as well as a detailed stratigraphic column illustrating the names, thicknesses, and ancient environments of rocks and formations that exist in the park. The Natural Resources section discusses some of the history and archeology of the park, as well as birds, mammals, plants, reptiles and environmental problems.

92

Great Basin National Park  

NSDL National Science Digital Library

This National Park Service site describes the biology of Great Basin's plants and animals; geology and ecology of the Lehman Caves; air quality of the park; and past human activities in the Great Basin such as farming, ranching, and gold mining. There is a list of historical, geological, and archeological dates important to the park and an instructor guide containing activities such as creating a nature notebook and adopting a tree. There is also information on: planning a visit to the park and the Lehman Caves, park projects such as weeding out non-native plants and the reintroduction of Bonneville Cutthroat Trout, and a self-guided geology field trip.

93

The National Park Service  

NSDL National Science Digital Library

This is the homepage of the National Park Service. It features links to subpages on special topics such as Parks and Recreation, which inludes links to individual national park pages, and History and Culture, which includes archeological, anthropological, and historical material. The Nature and Science pages feature classroom materials and information on the uses of science in protecting and restoring park ecosystems and research projects which are being conducted in the park system. The Interpretation and Education pages include games, online activities, and material for younger students who are researching park topics, as well as classroom materials for teachers. There are also links to the Park Service online bookshop, news articles, and special features.

94

Chicago Park District  

NSDL National Science Digital Library

The Chicago Park District is one of the largest municipal park systems in the United States, containing over 8,100 acres of green space. All told, the District has 580 parks, including two city conservatories, a number of historic lagoons, and the iconic Clarence Buckingham Memorial Fountain. This website allows visitors the opportunity to learn about the District's mission, history, and long-range planning for existing parks and potential new sites. On the homepage, visitors can use the Find a Park feature to learn about these diverse spaces. Additionally, they can use the I Want To area to learn about park permits, volunteering, and reporting problems within the park system. The Events area is quite a find, as visitors can learn about some of the hundreds of events sponsored each year by the District. Finally, visitors can also use the Doing Business area to learn about the various entrepreneurial activities which are possible via the District.

2013-01-01

95

Theme Park Insider  

NSDL National Science Digital Library

As summer enters full swing, more and more people will travel to America's numerous amusement parks and traveling carnivals. Quite a few of these people would do well to take a look at the Theme Park Insider website for reviews of various parks and the best (and worst) attractions at each particular place of amusement before they venture onto the open road. Edited by Robert Niles, the site contains reviews of new amusement park rides, an "Accident Watch" (which documents the latest accidents at each park), and reviews of theme park hotels as well. The site also has a number of discussion boards for visitors to chime in with their own take on a number of topics, such as which rides have the longest rides and general amusement park lore.

Niles, Robert.

96

78 FR 21413 - Notice of Intent To Repatriate Cultural Items: The Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Cultural Items: The Field Museum of Natural History, Chicago, IL AGENCY: National Park...SUMMARY: The Field Museum of Natural History, in consultation with the appropriate...request to The Field Museum of Natural History. If no additional claimants come...

2013-04-10

97

A Polyconvex Integrand; Euler-Lagrange Equations and Uniqueness of Equilibrium  

NASA Astrophysics Data System (ADS)

In this manuscript we are interested in stored energy functionals W defined on the set of d × d matrices, which not only fail to be convex but satisfy We initiate a study which we hope will lead to a theory for the existence and uniqueness of minimizers of functionals of the form , as well as their Euler-Lagrange equations. The techniques developed here can be applied to a class of functionals larger than those considered in this manuscript, although we keep our focus on polyconvex stored energy functionals of the form - such that - which appear in the study of Ogden material. We present a collection of perturbed and relaxed problems for which we prove uniqueness results. Then, we characterize these minimizers by their Euler-Lagrange equations.

Awi, Roméo; Gangbo, Wilfrid

2014-10-01

98

Solving inverse problems involving the Navier–Stokes equations discretized by a Lagrange–Galerkin method  

Microsoft Academic Search

In this article, we are investigating the numerical approximation of an inverse problem involving the evolution of a Newtonian viscous incompressible fluid described by the Navier–Stokes equations in 2D. This system is discretized using a low order finite element in space coupled with a Lagrange–Galerkin scheme for the nonlinear advection operator. We introduce a full discrete linearized scheme that is

Gilles Fourestey; Marwan Moubachir

2005-01-01

99

Distributed-Lagrange-Multiplier-based computational method for particulate flow with collisions  

Microsoft Academic Search

A Distributed-Lagrange-Multiplier-based computational method is developed for colliding particles in a solid-fluid system. A numerical simulation is conducted in two dimensions using the finite volume method. The entire domain is treated as a fluid but the fluid in the particle domains satisfies a rigidity constraint. We present an efficient method for predicting the collision between particles. In earlier methods, a

Arezoo Ardekani; Roger Rangel

2006-01-01

100

Lagrange relaxation and constraint programming collaborative schemes for travelling tournament problems  

Microsoft Academic Search

Abstract: This paper presents a study of hybrid algorithms combining,Lagrange relaxation and constraint programming,on a,problem,combining,round-robin assignment and travel optimization. Traveling Tournament Problems (TTP) have been identified a year ago asvery,hard ,problems ,requiring combinations ,from ,techniques ,of Operations Research (OR) and Constraint Programming (CP). Indeed, constrained round robin tournament,problems ,are now ,best solved using CP with global constraints while traveling salesman

Thierry Benoist; François Laburthe; Benoît Rottembourg

2001-01-01

101

A Free-Lagrange method for unsteady compressible flow: simulation of a confined cylindrical blast wave  

Microsoft Academic Search

A Free-Lagrange numerical procedure for the simulation of two-dimensional inviscid compressible flow is described in detail.\\u000a The unsteady Euler equations are solved on an unstructured Lagrangian grid based on a density-weighted Voronoi mesh. The flow\\u000a solver is of the Godunov type, utilising either the HLLE (2 wave) approximate Riemann solver or the more recent HLLC (3 wave)\\u000a variant, each adapted

G. J. Ball

1996-01-01

102

Shock-induced collapse of a cylindrical air cavity in water: a Free-Lagrange simulation  

Microsoft Academic Search

.   A Free-Lagrange CFD code is used to simulate the collapse of a cylindrical air cavity in water by a 1.9 GPa incident shock.\\u000a The Lagrangian treatment allows the air\\/water interface to be tracked throughout the interaction. The incident shock is partially\\u000a transmitted into the cavity, within which it experiences multiple reflections. The upstream cavity wall involutes to form\\u000a a

G. J. Ball; B. P. Howell; T. G. Leighton; M. J. Schofield

2000-01-01

103

Free-Lagrange simulations of the expansion and jetting collapse of air bubbles in water  

Microsoft Academic Search

A free-Lagrange numerical method is implemented to simulate the axisymmetric jetting collapse of air bubbles in water. This is performed for both lithotripter shock-induced collapses of initially stable bubbles, and for free-running cases where the bubble initially contains an overpressure. The code is validated using two test problems (shock-induced bubble collapse using a step shock, and shock10 MPa tensile waves,

C. K. Turangan; A. R. Jamaluddin; G. J. Ball; T. G. Leighton

2008-01-01

104

Shock-induced collapse of a cylindrical air cavity in water: a Free-Lagrange simulation  

Microsoft Academic Search

A Free-Lagrange CFD code is used to simulate the collapse of a cylindrical air cavity in water by a 1.9 GPa incident shock. The Lagrangian treatment allows the air\\/water interface to be tracked throughout the interaction. The incident shock is partially transmitted into the cavity, within which it experiences multiple reflections. The upstream cavity wall involutes to form a high-speed

G. J. Ball; B. P. Howell; T. G. Leighton; M. J. Schofield

2000-01-01

105

Application of extended Lagrange series to the precise determination of Global Positioning Satellite orbits  

NASA Astrophysics Data System (ADS)

A new semi-analytical method is presented for solving the calculation of the perturbed orbits of Global Positioning System (GPS) satellites. Preliminary notions concerning coordinates, Keplerian orbits, and the perturbed orbit are established. The basic principles of the analytical and numerical method are introduced along with the models of the principal perturbations affecting the GPS satellites. Different methods of orbit calculation are reviewed to demonstrate the main advantages and drawbacks of each. A comparison proves that the method of extended Lagrange series has many advantages. Contrary to Cowell's method, the extended Lagrange series method does not require any starting algorithm. The proposed method is distinguished from other techniques of integration by its simple formulation and for its facility in analyzing one or many perturbations. Results obtained using the MicroCosm program are presented which indicate that calculation of the orbit by the extended Lagrange series method is accurate to within 4 cm and 70 cm for short arcs of 6 and 10 hours respectively.

Huot, Caroline

1993-09-01

106

VISITOR PARKING Pay station parking meters are available around  

E-print Network

The City of Golden has implemented a permit policy in the residential areas surrounding campus. ParkingVISITOR PARKING Pay station parking meters are available around campus for visitors and other temporary parking needs. Daily scratch-off permits are available in advance from Parking Services. LOT METER

107

Parks, Recreation and Public Health.  

ERIC Educational Resources Information Center

Reviews what current research says about the holistic health benefits of park and recreation services, focusing on: health benefits according to park users; physical activities in parks; stress reduction benefits of park use; social support, self-determination, and stress reduction; observing nature in parks and associated benefits; and the…

Ho, Ching-Hua; Payne, Laura; Orsega-Smith, Elizabeth; Godbey, Geoffrey

2003-01-01

108

UCSF Mount Zion Vicinity Parking Public Parking Lots  

E-print Network

UCSF Mount Zion Vicinity Parking Public Parking Lots UCSF Valet Services Valet: 1600 Divisadero St Entrance on Scott between Sutter & Bush AMPCO System Parking 2186 Geary Blvd (415) 567-4656 Japantown

Walter, Peter

109

IL-19 Is a Component of the Pathogenetic IL-23/IL-17 Cascade in Psoriasis.  

PubMed

Psoriasis is a common chronic inflammatory disease with characteristic skin alterations and functions as a model of immune-mediated disorders. Cytokines have a key role in psoriasis pathogenesis. Here, we demonstrated that out of 30 individually quantified cytokines, IL-19 showed the strongest differential expression between psoriatic lesions and healthy skin. Cutaneous IL-19 overproduction was reflected by elevated IL-19 blood levels that correlated with psoriasis severity. Accordingly, anti-psoriatic therapies substantially reduced both cutaneous and systemic IL-19 levels. IL-19 production was induced in keratinocytes by IL-17A and was further amplified by tumor necrosis factor-? and IL-22. Among skin cells, keratinocytes were found to be important targets of IL-19. IL-19 alone, however, regulated only a few keratinocyte functions. While increasing the production of S100A7/8/9 and, to a moderate extent, also IL-1?, IL-20, chemokine C-X-C motif ligand 8, and matrix metalloproteinase 1, IL-19 had no clear influence on the differentiation, proliferation, or migration of these cells. Importantly, IL-19 amplified many IL-17A effects on keratinocytes, including the induction of ?-defensins, IL-19, IL-23p19, and T helper type 17-cell- and neutrophil-attracting chemokines. In summary, IL-19 as a component of the IL-23/IL-17 axis strengthens the IL-17A action and might be a biomarker for the activity of this axis in chronic inflammatory disorders. PMID:25046339

Witte, Ellen; Kokolakis, Georgios; Witte, Katrin; Philipp, Sandra; Doecke, Wolf-Dietrich; Babel, Nina; Wittig, Bianca M; Warszawska, Katarzyna; Kurek, Agata; Erdmann-Keding, Magdalena; Kunz, Stefanie; Asadullah, Khusru; Kadin, Marshall E; Volk, Hans-Dieter; Sterry, Wolfram; Wolk, Kerstin; Sabat, Robert

2014-11-01

110

2010 TRANSPORTATION & PARKING SERVICES ACCOMPLISHMENTS  

E-print Network

­ Transportation & Parking Services Calendar Year 2010 1 AREA FOCUS ACCOMPLISHMENT Quality Best Practice TAPS the campus to remove unauthorized postings from parking lots, campus streets and immediate surrounding areas2010 TRANSPORTATION & PARKING SERVICES ACCOMPLISHMENTS #12;2010 ACCOMPLISHMENTS TRANSPORTATION

Mills, Allen P.

111

Downtown-parking policy analysis  

SciTech Connect

This article outlines a framework for recognizing city parking policy alternatives and evaluating their effectiveness or desirability for solving parking problems. The techniques are useful for making parking policy decisions. 6 references, 1 table.

Kuner, R.

1983-10-01

112

Splendor In The Parks.  

ERIC Educational Resources Information Center

Civilization is more and more intruding on the esthetic and recreational resources of the National Park System. Increased attention must be paid to controlling noise, pollution, and even the effects of urban lighting which detract from the enjoyment of the parks. (RE)

Smith, Anthony Wayne

1979-01-01

113

Roswell Park Cancer Institute  

Cancer.gov

Roswell Park Cancer Institute (RPCI) was the first cancer center in the United States when it was founded in 1898 by Dr. Roswell Park. In 1974, RPCI received its NCI designation as a comprehensive cancer center. RPCI also serves as a member of the National Comprehensive Cancer Network.

114

NEW WESTMINSTER PARK & RIDE  

E-print Network

PATTERSON JOYCE 29th AVE NANAIMO SCOTT ROAD GATEWAY COLUMBIA BROADWAY MAIN STREET KOOTENAY LOOP PNE PARK TRANSIT EXCHANGE PORT MOODY COQUITLAM REC CENTRE LOUGHEED PARK & RIDE SCOTT RD 104 AVE 108 AVE OLD YALE TH ERMAL DRIVE HERITA GE MOUNT AINBOULEVA R D BARNET I IOCO ROAD UNITED BOULEVARD NORTHROADNORTHROAD

Haunerland, Norbert H.

115

Mammoth Cave National Park  

NSDL National Science Digital Library

The homepage of Mammoth Cave National Park provides visitors with information on tour schedules, surface activities, lodging and camping, and tips on touring caves. Teachers can access an extensive selection of curricular materials, fact sheets and activities for kids, a glossary, and links to other educational programs and sites. Other materials include maps and publications, an image gallery, and links to the park's newsletter.

116

Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma  

PubMed Central

Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, hyper secretion of mucus, edema and airway hyper responsiveness (AHR), mucus secretion and thickening of the basement membrane underlying the airway epithelium. During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. It was believed that airway inflammation is orchestrated by allergen specific T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. Th17 cell may have a role in severe asthma and chronic obstructive pulmonary disease (COPD). Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor-? and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. Cytokines are important in asthma and play a critical role in orchestrating the allergic inflammatory response, although the precise role of each cytokine remains to be determined. The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. The potential therapeutic applications emerging from the roles of these cytokines will be discussed as well. PMID:24949298

Farahani, Rahim; Sherkat, Roya; Hakemi, Mazdak Ganjalikhani; Eskandari, Nahid; Yazdani, Reza

2014-01-01

117

IL28, IL29 and their class II cytokine receptor IL28R  

Microsoft Academic Search

Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by

Paul Sheppard; Wayne Kindsvogel; Wenfeng Xu; Katherine Henderson; Stacy Schlutsmeyer; Theodore E. Whitmore; Rolf Kuestner; Ursula Garrigues; Carl Birks; Jenny Roraback; Craig Ostrander; Dennis Dong; Jinu Shin; Scott Presnell; Brian Fox; Betty Haldeman; Emily Cooper; David Taft; Teresa Gilbert; Francis J. Grant; Monica Tackett; William Krivan; Gary McKnight; Chris Clegg; Don Foster; Kevin M. Klucher

2002-01-01

118

76 FR 28067 - Notice of Intent To Repatriate Cultural Items: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Cultural Items: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History (Field Museum), Chicago, IL, that...In 1999, the Field Museum of Natural History acquired the cultural items as a...

2011-05-13

119

76 FR 28067 - Notice of Intent To Repatriate Cultural Items: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Cultural Items: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History (Field Museum), Chicago, IL, that...the items to the Field Museum of Natural History. The items were accessioned into...

2011-05-13

120

Defunct Amusement Parks  

NSDL National Science Digital Library

While there are many sites on existing amusement parks, this particular Web site contains detailed information on "pleasure palaces" that have gone out of business or that have since been demolished. Created and maintained by Joel Styer, the site features an interactive map of the United States that allows visitors to click on any one of the states to find out information about now-defunct amusement parks. Many of the former parks have additional material available for viewing, such as photographs, postcards, and brief essays and personal remembrances. Also, there is an extensive links page, which directs visitors to other sites dealing with different aspects of amusement park memorabilia such as popular rides from the past and newsgroups. The site also has different contact information for persons seeking to donate materials and recollections related to amusement parks.

1995-01-01

121

Florida State Parks  

NSDL National Science Digital Library

The modern Florida State Parks system was created in 1935, and their programs include parks all the way from the St. Augustine area to the Keys. Their homepage brings together cultural, historical, and scientific materials related to the various sites in the state system. The website includes information on each park, along with interactive features on African American sites in the state and notable battlegrounds. Along the top of the page, visitors can use sections such as "Find a Park" and "Stay the Night" to plan their journey through the state. Each park entry also contains information about the site's history, along with detailed information about ranger programs, special music events, and so on. Finally, visitors can stay in touch via Twitter and other social media.

122

Domain decomposition methods for nonconforming finite element spaces of Lagrange-type  

NASA Technical Reports Server (NTRS)

In this article, we consider the application of three popular domain decomposition methods to Lagrange-type nonconforming finite element discretizations of scalar, self-adjoint, second order elliptic equations. The additive Schwarz method of Dryja and Widlund, the vertex space method of Smith, and the balancing method of Mandel applied to nonconforming elements are shown to converge at a rate no worse than their applications to the standard conforming piecewise linear Galerkin discretization. Essentially, the theory for the nonconforming elements is inherited from the existing theory for the conforming elements with only modest modification by constructing an isomorphism between the nonconforming finite element space and a space of continuous piecewise linear functions.

Cowsar, Lawrence C.

1993-01-01

123

UVA Parking and Transportation Student Parking Application Form  

E-print Network

areas at the same time unless full fees have been paid for each vehicle. Please notify ParkingUVA Parking and Transportation Student Parking Application Form Please Print Clearly: Primary other than yourself, a parent, or spouse. Only one vehicle per family or carpool may park in permit

Acton, Scott

124

Stag Hill Campus Manor Park,  

E-print Network

R Chancellors SU Mole 23 W Bourne 22 Black Water 21 Wey 27 Thames 24 Wandle 26Tilling Bourne 25 (Securitypermissionrequired) Laundrette Lakeside Restaurant Lakeside Coffee Shop Railway N Vehicle route to Manor Park Legend.ac.uk/about/visitors/travel Parking with a permit Between 7.30am and 5pm, Monday to Friday, parking in all car parks other than

Jones, Peter JS

125

Vehicle Operation and Parking Policy  

E-print Network

.3 Students are not authorized to park in reserved/restricted parking areas during regular business hours. 3Vehicle Operation and Parking Policy Responsible Administrative Unit: Finance & Administration ordinances and State of Colorado traffic laws on driveways and streets located on CSM property. Parking

126

PARKING PERMITS Conditions of Issue  

E-print Network

of a Temporary Notice Parking in unauthorised areas including but not limited to: a. Yellowed lined roads b. Hatched areas c. Reserved parking areas (temporary or permanent) d. No parking zones e. Disabled bays Park (No.1) / Sports Centre and Wales National Pool pay and display. i. Any other area which is likely

Martin, Ralph R.

127

Vehicle Operation and Parking Policy  

E-print Network

.3 Students are not authorized to park in reserved/restricted parking areas during regular business hours. 3Vehicle Operation and Parking Policy Responsible Administrative Unit: Finance & Administration of Colorado traffic laws on driveways and streets located on CSM property. Parking Services employees possess

128

On fractional Euler-Lagrange and Hamilton equations and the fractional generalization of total time derivative  

E-print Network

Fractional mechanics describes both conservative and non-conservative systems. The fractional variational principles gained importance in studying the fractional mechanics and several versions are proposed. In classical mechanics the equivalent Lagrangians play an important role because they admit the same Euler-Lagrange equations. By adding a total time derivative of a suitable function to a given classical Lagrangian or by multiplying with a constant the Lagrangian we obtain the same equations of motion. In this study, the fractional discrete Lagrangians which differs by a fractional derivative are analyzed within Riemann-Liouville fractional derivatives. As a consequence of applying this procedure the classical results are reobtained as a special case. The fractional generalization of $Fa\\grave{a}$ di Bruno formula is used in order to obtain the concrete expression of the fractional Lagrangians which differs from a given fractional Lagrangian by adding a fractional derivative. The fractional Euler-Lagrange and Hamilton equations corresponding to the obtained fractional Lagrangians are investigated and two examples are analyzed in details.

Dumitru Baleanu; Sami I. Muslih; Eqab M. Rabei

2007-08-13

129

Generating true minima in constrained variational formulations via modified Lagrange multipliers  

NASA Astrophysics Data System (ADS)

Variational principles are important in the investigation of large classes of physical systems. They can be used both as analytical methods as well as starting points for the formulation of powerful computational techniques such as dynamical optimization methods. Systems with charged objects in dielectric media and systems with magnetically active particles are important examples. In these examples and other important cases, the variational principles describing the system are required to obey a number of constraints. These constraints are implemented within the variational formulation by means of Lagrange multipliers. Such constrained variational formulations are in general not unique. For the application of efficient simulation methods, one must find specific formulations that satisfy a number of important conditions. An often required condition is that the functional be positive-definite, in other words, its extrema be actual minima. In this article, we present a general approach to attack the problem of finding, among equivalent variational functionals, those that generate true minima. The method is based on the modification of the Lagrange multiplier which allows us to generate large families of effective variational formulations associated with a single original constrained variational principle. We demonstrate its application to different examples and, in particular, to the important cases of Poisson and Poisson-Boltzmann equations. We show how to obtain variational formulations for these systems with extrema that are always minima.

Solis, Francisco J.; Jadhao, Vikram; Olvera de la Cruz, Monica

2013-11-01

130

Volumetric Displacement Effects In Euler-Lagrange Simulations of Sediment-Laden Oscillatory Flows  

NASA Astrophysics Data System (ADS)

An improved, three-dimensional approach for Euler-Lagrange simulation of sediment-laden oscillatory turbulent flows is developed. In this approach, the sediment particles are unresolved and subgrid similar to a discrete element model (DEM), however, the fluid volume (mass) displaced by the particle is accounted for in the conservation equations. Recent Euler-Lagrange modeling of a few microbubbles entrained in a traveling vortex ring (Cihonski et al., JFM, 2013) has shown that extension of the standard point-particle DEM method to include local volume displacement effects is critical in capturing vortex distortion effects due to microbubbles, even in a very dilute suspension. We extend this approach to investigate particle-laden oscillatory boundary layers representative of coastal sediment environments. A wall bounded, doubly periodic domain is considered laden with a layer of sediment particles in laminar as well as turbulent oscillatory boundary layers corresponding to the experiments of Keiller and Sleath (1987) and Jensen et al. (1987). Inter-particle and particle-wall collisions are modeled using a soft-sphere model which uses a nested collision grid to minimize computational effort. The effects of fluid mass displaced by the particles on the flow statistics are quantified by comparing a standard two-way coupling approach (without volume displacement effects) with volume displacement effects to show that the latter models are important for cases with low specific gravity.

Apte, S.; Finn, J. R.; Cihonski, A.

2013-12-01

131

Pacific Historic Parks  

NSDL National Science Digital Library

Designed to support and fund educational materials and interpretive programs for four National Parks throughout the Pacific (including the Kalaupapa National Historical Park), the Pacific Historic Parks organization has a visually enticing website. On the homepage, visitors will find information about their work in four sections, including "Education" and "Locations". First-time visitors may want to start by looking over the "Locations" area. Here they will find information about each park, complete with a Google Map interface that will let them learn more about each site. In the "Education" area, visitors can download a copy of their educational brochure and also take a look at several of their booklets for educators. Moving on, the "Audio Tour" area contains a copy of the accompanying brochure for an audio tour narrated by actor Jamie Lee Curtis.

132

Student Accommodation Liberty Park  

E-print Network

office � 24-hour Security/ CCTV / Access entry system � Non smoking building #12;Carlton Hill Carlton storage facilities � Car Park permit system in operation � Garden area � CCTV cameras fitted

Stell, John

133

High School Parking Lots.  

ERIC Educational Resources Information Center

Describes the reorganization of the site of Ben Davis High School in Wayne Township, Indiana as an example of improvements to school parking lot design and vehicle/pedestrian traffic flow and security. Includes design drawings. (EV)

Neff, Thomas G.

2002-01-01

134

Jurassic Park Safety Audit  

NSDL National Science Digital Library

Using the first 30 minutes of the film Jurassic Park, the student will audit it for violations of safety rules and regulations, OSHA violations, and violations of HASP's. Access to the activity required free and quick registration with ATEEC.

2007-09-18

135

The National Park Service: Park Geology  

NSDL National Science Digital Library

A National Park Service (NPS) site primarily composed of three main sections corresponding to the following program areas within the Geologic Resources Division (GRD): Disturbed Lands Restoration and Abandoned Mineral Lands (AML), Mineral Management Programs, and Geology and Soils Programs. Of these, the first two consist principally of textual resources pertaining to Park System procedures, policies, and regulations - as well as reports on example restoration projects with a focus on stream corridor restoration, bioengineering, riparian management, and revegetation. Perhaps of most interest to educators will be the third main program area, the Geology and Soils Programs section. Here are included textual resources pertaining to NPS-GRD programs on cave and karst formations, coastal and shoreline geology, paleontology, soils (e.g., soil biology and soil surveying), geological indicators (geoindicators), and stratigraphy. Lastly, a searchable photographic collection and geologic glossary are available.

136

A Lagrange multiplier approach for excited state properties through intermediate Hamiltonian formulation of Fock space multireference coupled-cluster theory.  

PubMed

In this paper, we present a formulation based on Lagrange multiplier approach for efficient evaluation of excited state energy derivatives in Fock space coupled cluster theory within the intermediate Hamiltonian framework. The formulation is applied to derive the explicit generic expressions up to second order energy derivatives for [1, 1] sector of Fock space with singles and doubles approximation. Its advantage, efficiency, and interconnection in comparison to the Lagrange multiplier approach in traditional formulation of Fock space, which is built on the concept of Bloch equation based effective Hamiltonian, has been discussed. Computational strategy for their implementation has also been discussed in some detail. PMID:23968073

Gupta, Jitendra; Vaval, Nayana; Pal, Sourav

2013-08-21

137

Geology Fieldnotes: Great Basin National Park, Nevada  

NSDL National Science Digital Library

This Great Basin National Park site contains park geology information, park maps, visitor information, and teacher features (educational resources and links for teaching geology using National Park examples). The park geology section discusses the region's biogeography, glacial history, and the Lehman Caves. A park map and a features/relief map of the Great Basin National Park are included.

138

Park Geology: Tour of Basin and Range Parks  

NSDL National Science Digital Library

This site provides links to tours of individual National Parks within the Basin and Range region. Where appropriate for each park, links are provided to park geology, maps, photographs, geologic research, related links, visitor information, multimedia resources, and teacher features. Some of the parks have an expanded geology page that features the geologic time, history, plate tectonics, rocks and minerals, and a virtual field trip of the park. Of particular note is the teacher feature section, which provides educational resources and links for teaching geology with National Park examples.

139

STANFORD UNIVERSITY TRAFFIC AND PARKING CODE  

E-print Network

Section 3.2 Parking Areas - Designation................................................ 10 Section 3.5 Parking Areas ­ Use Thereof.................................................................... 11 Section 3.6 Parking Areas- Pedestrian Zone (PZ

Straight, Aaron

140

Taylor-Lagrange renormalization scheme: Application to light-front dynamics  

SciTech Connect

The recently proposed renormalization scheme based on the definition of field operators as operator valued distributions acting on specific test functions is shown to be very convenient in explicit calculations of physical observables within the framework of light-front dynamics. We first recall the main properties of this procedure based on identities relating the test functions to their Taylor remainder of any order expressed in terms of Lagrange's formulas, hence the name given to this scheme. We thus show how it naturally applies to the calculation of state vectors of physical systems in the covariant formulation of light-front dynamics. As an example, we consider the case of the Yukawa model in the simple two-body Fock state truncation.

Grange, P.; Mutet, B. [Laboratoire de Physique Theorique et Astroparticules, Universite Montpellier II, CNRS/IN2P3, Place E. Bataillon, F-34095 Montpellier Cedex 05 (France); Mathiot, J.-F. [Clermont Universite, Universite Blaise Pascal, Laboratoire de Physique Corpusculaire, BP 10448, F-63000 Clermont-Ferrand (France); CNRS/IN2P3, UMR6533, LPC, F-63177 Aubiere Cedex (France); Werner, E. [Institut fuer Theoretische Physik, Universitaet Regensburg, Universitaetstrasse 31, D-93053 Regensburg (Germany)

2009-11-15

141

Design of multichannel DWDM fiber Bragg grating filters by Lagrange multiplier constrained optimization.  

PubMed

We present the synthesis of multi-channel fiber Bragg grating (MCFBG) filters for dense wavelength-division-multiplexing (DWDM) application by using a simple optimization approach based on a Lagrange multiplier optimization (LMO) method. We demonstrate for the first time that the LMO method can be used to constrain various parameters of the designed MCFBG filters for practical application demands and fabrication requirements. The designed filters have a number of merits, i.e., flat-top and low dispersion spectral response as well as single stage. Above all, the maximum amplitude of the index modulation profiles of the designed MCFBGs can be substantially reduced under the applied constrained condition. The simulation results demonstrate that the LMO algorithm can provide a potential alternative for complex fiber grating filter design problems. PMID:19529515

Lee, Cheng-Ling; Lee, Ray-Kuang; Kao, Yee-Mou

2006-11-13

142

Augmented Lagrange Based on Modified Covariance Matching Criterion Method for DOA Estimation in Compressed Sensing  

PubMed Central

A novel direction of arrival (DOA) estimation method in compressed sensing (CS) is presented, in which DOA estimation is considered as the joint sparse recovery from multiple measurement vectors (MMV). The proposed method is obtained by minimizing the modified-based covariance matching criterion, which is acquired by adding penalties according to the regularization method. This minimization problem is shown to be a semidefinite program (SDP) and transformed into a constrained quadratic programming problem for reducing computational complexity which can be solved by the augmented Lagrange method. The proposed method can significantly improve the performance especially in the scenarios with low signal to noise ratio (SNR), small number of snapshots, and closely spaced correlated sources. In addition, the Cramér-Rao bound (CRB) of the proposed method is developed and the performance guarantee is given according to a version of the restricted isometry property (RIP). The effectiveness and satisfactory performance of the proposed method are illustrated by simulation results. PMID:24678272

Si, Weijian; Qu, Xinggen; Liu, Lutao

2014-01-01

143

On a Lagrange-Hamilton formalism describing position and momentum uncertainties  

NASA Technical Reports Server (NTRS)

According to Heisenberg's uncertainty relation, in quantum mechanics it is not possible to determine, simultaneously, exact values for the position and the momentum of a material system. Calculating the mean value of the Hamiltonian operator with the aid of exact analytic Gaussian wave packet solutions, these uncertainties cause an energy contribution additional to the classical energy of the system. For the harmonic oscillator, e.g., this nonclassical energy represents the ground state energy. It will be shown that this additional energy contribution can be considered as a Hamiltonian function, if it is written in appropriate variables. With the help of the usual Lagrange-Hamilton formalism known from classical particle mechanics, but now considering this new Hamiltonian function, it is possible to obtain the equations of motion for position and momentum uncertainties.

Schuch, Dieter

1993-01-01

144

Augmented lagrange hopfield network for economic dispatch with multiple fuel options  

SciTech Connect

This paper proposes an augmented Lagrange Hopfield network (ALHN) for solving economic dispatch (ED) problem with multiple fuel options. The proposed ALHN method is a continuous Hopfield neural network with its energy function based on augmented Lagrangian function. The advantages of ALHN over the conventional Hopfield neural network are easier use, more general applications, faster convergence, better optimal solution, and larger scale of problem implementation. The method solves the problem by directly searching the most suitable fuel among the available fuels of each unit and finding the optimal solution for the problem based on minimization of the energy function of the continuous Hopfield neural network. The proposed method is tested on systems up to 100 units and the obtained results are compared to those from other methods in the literature. The results have shown that the proposed method is efficient for solving the ED problem with multiple fuel options and favorable for implementation in large scale problems.

Dieu, Vo Ngoc; Ongsakul, Weerakorn; Polprasert, Jirawadee [Energy Field of Study, School of Environment, Resources and Development, Asian Institute of Technology, Klongluang, Pathumthani (Thailand)

2011-06-20

145

Testing of Lagrange multiplier damped least-squares control algorithm for woofer-tweeter adaptive optics  

PubMed Central

A Lagrange multiplier-based damped least-squares control algorithm for woofer-tweeter (W-T) dual deformable-mirror (DM) adaptive optics (AO) is tested with a breadboard system. We show that the algorithm can complementarily command the two DMs to correct wavefront aberrations within a single optimization process: the woofer DM correcting the high-stroke, low-order aberrations, and the tweeter DM correcting the low-stroke, high-order aberrations. The optimal damping factor for a DM is found to be the median of the eigenvalue spectrum of the influence matrix of that DM. Wavefront control accuracy is maximized with the optimized control parameters. For the breadboard system, the residual wavefront error can be controlled to the precision of 0.03 ?m in root mean square. The W-T dual-DM AO has applications in both ophthalmology and astronomy. PMID:22441462

Zou, Weiyao; Burns, Stephen A.

2012-01-01

146

Shock-induced collapse of a cylindrical air cavity in water: a Free-Lagrange simulation  

NASA Astrophysics Data System (ADS)

A Free-Lagrange CFD code is used to simulate the collapse of a cylindrical air cavity in water by a 1.9 GPa incident shock. The Lagrangian treatment allows the air/water interface to be tracked throughout the interaction. The incident shock is partially transmitted into the cavity, within which it experiences multiple reflections. The upstream cavity wall involutes to form a high-speed jet which, on impact with the far cavity wall, produces an intense blast wave. Heating of the gas within the cavity is highly non-isentropic, and is dominated by shock heating. The predicted final gas temperature is of order 12000 K, although the modelling assumptions used here lead to over-prediction of temperature during the later stages of collapse.

Ball, G. J.; Howell, B. P.; Leighton, T. G.; Schofield, M. J.

147

Post-Newtonian effects on Lagrange's equilateral triangular solution for the three-body problem  

SciTech Connect

Continuing work initiated in earlier publications [Yamada, Asada, Phys. Rev. D 82, 104019 (2010); ibid.83, 024040 (2011)], we investigate the post-Newtonian effects on Lagrange's equilateral triangular solution for the three-body problem. For three finite masses, it is found that the equilateral triangular configuration satisfies the post-Newtonian equation of motion in general relativity, if and only if all three masses are equal. When a test mass is included, the equilateral configuration is possible for two cases: (1) one mass is finite and the other two are zero, or (2) two of the masses are finite and equal, and the third one is zero, namely, a symmetric binary with a test mass. The angular velocity of the post-Newtonian equilateral triangular configuration is always smaller than the Newtonian one, provided that the masses and the side length are the same.

Ichita, Takumi; Yamada, Kei; Asada, Hideki [Faculty of Science and Technology, Hirosaki University, Hirosaki 036-8561 (Japan)

2011-04-15

148

Post-Newtonian effects on Lagrange's equilateral triangular solution for the three-body problem  

E-print Network

Continuing work initiated in earlier publications [Yamada, Asada, Phys. Rev. D 82, 104019 (2010), 83, 024040 (2011)], we investigate the post-Newtonian effects on Lagrange's equilateral triangular solution for the three-body problem. For three finite masses, it is found that the equilateral triangular configuration satisfies the post-Newtonian equation of motion in general relativity, if and only if all three masses are equal. When a test mass is included, the equilateral configuration is possible for two cases: (1) one mass is finite and the other two are zero, or (2) two of the masses are finite and equal, and the third one is zero, namely a symmetric binary with a test mass. The angular velocity of the post-Newtonian equilateral triangular configuration is always smaller than the Newtonian one, provided that the masses and the side length are the same.

Takumi Ichita; Kei Yamada; Hideki Asada

2010-11-17

149

Modal control of a satellite in an unstable periodic orbit about the Earth-Sun interior Lagrange point  

Microsoft Academic Search

A periodic 'halo' orbit which exists about the interior Lagrange point for the Earth-sun system was decomposed using Floquet theory into modal variables, which are dynamically decoupled subspaces for the six degree of freedom system. Modal control consisted of evaluating the diverging mode and maneuvering to counteract its divergence. In the unperturbed system, this was successful. Control costs were low,

Douglas J. Hopper

1993-01-01

150

Application of the Lagrange-Souriau form method to the case of source-free electromagnetic field  

E-print Network

The recent method of the description of classical fields in terms of Lagrange-Souriau form is applied to the case of source-free electromagnetic field in order to check its computational capabilities. The relevant calculations are represented in all details and yield a useful data for comparisons of the method with more usual approaches in this simple and transparent case.

S. Tertychniy

1993-12-29

151

IL-33 enhanced the proliferation and constitutive production of IL-13 and IL-5 by fibrocytes.  

PubMed

Interleukin-33 appears to play important roles in the induction of allergic airway inflammation. However, whether IL-33 is involved in airway remodeling remains unclear. Because fibrocytes contribute to tissue remodeling in the setting of chronic inflammation, we examined the effects of IL-33 on fibrocyte functions. Fibrocytes were generated in vitro from peripheral blood mononuclear cells by culturing in the presence of platelet derived growth factors and the cells were stimulated with IL-33. IL-33 enhanced cell proliferation, ?-SMA expression, and pro-MMP-9 activity by the fibrocytes without increasing endogenous transforming growth factor-?1 production. Fibrocytes constitutively expressed IL-13 and IL-5, and their production was augmented by stimulation with IL-33. Dexamethasone inhibited the functions of fibrocytes, but IL-33 made fibrocytes slightly refractory to the inhibitory effect of dexamethasone in terms of IL-13 production. Montelukast suppressed IL-13 production by nonstimulated fibrocytes but not those stimulated by IL-33. These findings suggest that IL-33 is involved in the airway remodeling process through its modulation of fibrocyte function independent of antigen stimulation. IL-33 might partially reduce the therapeutic effects of glucocorticoid and cysteinyl leukotriene receptor antagonist on fibrocyte-mediated Th2 responses. PMID:24822215

Hayashi, Hisako; Kawakita, Akiko; Okazaki, Shintaro; Murai, Hiroki; Yasutomi, Motoko; Ohshima, Yusei

2014-01-01

152

IL-33 Enhanced the Proliferation and Constitutive Production of IL-13 and IL-5 by Fibrocytes  

PubMed Central

Interleukin-33 appears to play important roles in the induction of allergic airway inflammation. However, whether IL-33 is involved in airway remodeling remains unclear. Because fibrocytes contribute to tissue remodeling in the setting of chronic inflammation, we examined the effects of IL-33 on fibrocyte functions. Fibrocytes were generated in vitro from peripheral blood mononuclear cells by culturing in the presence of platelet derived growth factors and the cells were stimulated with IL-33. IL-33 enhanced cell proliferation, ?-SMA expression, and pro-MMP-9 activity by the fibrocytes without increasing endogenous transforming growth factor-?1 production. Fibrocytes constitutively expressed IL-13 and IL-5, and their production was augmented by stimulation with IL-33. Dexamethasone inhibited the functions of fibrocytes, but IL-33 made fibrocytes slightly refractory to the inhibitory effect of dexamethasone in terms of IL-13 production. Montelukast suppressed IL-13 production by nonstimulated fibrocytes but not those stimulated by IL-33. These findings suggest that IL-33 is involved in the airway remodeling process through its modulation of fibrocyte function independent of antigen stimulation. IL-33 might partially reduce the therapeutic effects of glucocorticoid and cysteinyl leukotriene receptor antagonist on fibrocyte-mediated Th2 responses. PMID:24822215

Hayashi, Hisako; Kawakita, Akiko; Okazaki, Shintaro; Murai, Hiroki; Yasutomi, Motoko; Ohshima, Yusei

2014-01-01

153

Mesoscale Simulations of Particulate Flows with Parallel Distributed Lagrange Multiplier Technique  

SciTech Connect

Fluid particulate flows are common phenomena in nature and industry. Modeling of such flows at micro and macro levels as well establishing relationships between these approaches are needed to understand properties of the particulate matter. We propose a computational technique based on the direct numerical simulation of the particulate flows. The numerical method is based on the distributed Lagrange multiplier technique following the ideas of Glowinski et al. (1999). Each particle is explicitly resolved on an Eulerian grid as a separate domain, using solid volume fractions. The fluid equations are solved through the entire computational domain, however, Lagrange multiplier constrains are applied inside the particle domain such that the fluid within any volume associated with a solid particle moves as an incompressible rigid body. Mutual forces for the fluid-particle interactions are internal to the system. Particles interact with the fluid via fluid dynamic equations, resulting in implicit fluid-rigid-body coupling relations that produce realistic fluid flow around the particles (i.e., no-slip boundary conditions). The particle-particle interactions are implemented using explicit force-displacement interactions for frictional inelastic particles similar to the DEM method of Cundall et al. (1979) with some modifications using a volume of an overlapping region as an input to the contact forces. The method is flexible enough to handle arbitrary particle shapes and size distributions. A parallel implementation of the method is based on the SAMRAI (Structured Adaptive Mesh Refinement Application Infrastructure) library, which allows handling of large amounts of rigid particles and enables local grid refinement. Accuracy and convergence of the presented method has been tested against known solutions for a falling sphere as well as by examining fluid flows through stationary particle beds (periodic and cubic packing). To evaluate code performance and validate particle contact physics algorithm, we performed simulations of a representative experiment conducted at the University of California at Berkley for pebble flow through a narrow opening.

Kanarska, Y

2010-03-24

154

LAGRANGE SOLUTIONS TO THE DISCRETE-TIME GENERAL THREE-BODY PROBLEM  

SciTech Connect

There is no known integrator that yields exact orbits for the general three-body problem (G3BP). It is difficult to verify whether a numerical procedure yields the correct solutions to the G3BP because doing so requires knowledge of all 11 conserved quantities, whereas only six are known. Without tracking all of the conserved quantities, it is possible to show that the discrete general three-body problem (d-G3BP) yields the correct orbits corresponding to Lagrange solutions of the G3BP. We show that the d-G3BP yields the correct solutions to the G3BP for two special cases: the equilateral triangle and collinear configurations. For the triangular solution, we use the fact that the solution to the three-body case is a superposition of the solutions to the three two-body cases, and we show that the three bodies maintain the same relative distances at all times. To obtain the collinear solution, we assume a specific permutation of the three bodies arranged along a straight rotating line, and we show that the d-G3BP maintains the same distance ratio between two bodies as in the G3BP. Proving that the d-G3BP solutions for these cases are equivalent to those of the G3BP makes it likely that the d-G3BP and G3BP solutions are equivalent in other cases. To our knowledge, this is the first work that proves the equivalence of the discrete solutions and the Lagrange orbits.

Minesaki, Yukitaka [Tokushima Bunri University, Nishihama, Yamashiro-cho, Tokushima 770-8514 (Japan)

2013-03-15

155

FACING NORTHEAST OF NORTHERN BOUNDARY OF PARK Candler Park ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FACING NORTHEAST OF NORTHERN BOUNDARY OF PARK - Candler Park Historic District, Roughly bounded by Moreland, Dekalb, McLendon & Harold Avenues, Matthews Street & Clifton Terrace, Atlanta, Fulton County, GA

156

FACING NORTHWEST TOWARD NORTHERN END OF PARK Candler Park ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FACING NORTHWEST TOWARD NORTHERN END OF PARK - Candler Park Historic District, Roughly bounded by Moreland, Dekalb, McLendon & Harold Avenues, Matthews Street & Clifton Terrace, Atlanta, Fulton County, GA

157

View from Fort Tryon Park of Fort Washington Park, Hudson ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View from Fort Tryon Park of Fort Washington Park, Hudson River, and Palisades Interstate Park, looking northeast. Dyckman Street viaduct, marina and playing fields are faintly visible below. - Henry Hudson Parkway, Extending 11.2 miles from West 72nd Street to Bronx-Westchester border, New York, New York County, NY

158

NASA Research Park  

NSDL National Science Digital Library

A massive addition to the NASA Ames Research Park is detailed on this site. Although the project is not scheduled to be completed until 2015, it has been in the planning stages for several years and 2003 marks the beginning of Phase 1. The 98-page NASA Ames Development Plan is available for public viewing online. The new facilities will be designed to accommodate research in "information technology, nanotechnology, biotechnology, and astrobiology." Several other news articles and formal documents about the project can be downloaded as well. The design, construction, and staffing of the new research park will reportedly generate 7,000 high-tech jobs.

2000-01-01

159

32 CFR 636.14 - Parking.  

Code of Federal Regulations, 2012 CFR

...handicapped parking spaces and parking on a yellow curb among others. (b) Reserved parking spaces in areas under the control...these spaces. (c) Parking spaces for tactical vehicles...Exchange/Commissary area will be...

2012-07-01

160

32 CFR 636.14 - Parking.  

Code of Federal Regulations, 2013 CFR

...handicapped parking spaces and parking on a yellow curb among others. (b) Reserved parking spaces in areas under the control...these spaces. (c) Parking spaces for tactical vehicles...Exchange/Commissary area will be...

2013-07-01

161

32 CFR 636.14 - Parking.  

Code of Federal Regulations, 2011 CFR

...handicapped parking spaces and parking on a yellow curb among others. (b) Reserved parking spaces in areas under the control...these spaces. (c) Parking spaces for tactical vehicles...Exchange/Commissary area will be...

2011-07-01

162

32 CFR 636.14 - Parking.  

Code of Federal Regulations, 2010 CFR

...handicapped parking spaces and parking on a yellow curb among others. (b) Reserved parking spaces in areas under the control...these spaces. (c) Parking spaces for tactical vehicles...Exchange/Commissary area will be...

2010-07-01

163

{00029558 / ver 1 } 1 Parking Regulations  

E-print Network

received from any other source is not considered a valid defense of parking violations. All vehicles parked: There is no overnight parking allowed in A or Z lots without prior approval from Parking Services. Vehicles left

164

76 FR 80393 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013

...Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY: National Park...SUMMARY: The Field Museum of Natural History has completed an inventory of human remains...may contact the Field Museum of Natural History. Repatriation of the human remains...

2011-12-23

165

Carbon Park Environmental Impact Assessment  

E-print Network

of offsetting the University's carbon footprint, promoting biodiversity and establishing easily maintained Carbon Park Environmental Impact Assessment A B.E.S.T. Project By, Adam Bond 2011 #12; Bishop's University Carbon Park

166

Careers in Parks and Recreation.  

ERIC Educational Resources Information Center

As reported in the document, the park and recreation profession, a growing field, emphasizes involving people in meaningful leisure activities. This service profession offers varied career opportunities in the areas of public recreation, park management, conservation and outdoor recreation, and park and resource planning. Positions are also…

Oregon Univ., Eugene. Center of Leisure Studies.

167

Traffic and Parking Financial Statements  

E-print Network

that the financial position of Traffic & Parking is healthy. The University's management, which oversees Traffic. In the University's planning process for Traffic & Parking issues, management put into place the appropriateTraffic and Parking Financial Statements June 30, 2008 #12;FLORIDA ATLANTIC UNIVERSITY TRAFFIC

Fernandez, Eduardo

168

Dry Tortugas National Park, Florida  

NSDL National Science Digital Library

This National Park Service (NPS) publication discusses Dry Tortugas National Park in Florida. This system consists of 7 small islands off the coast of Key West. The site discusses the history of this area, as well as the marine setting of the park.

169

Key to symbols Permit Parking  

E-print Network

Gottingen St. Legal Aid Services G100 Fenwick Place 5599 Fenwick St. Student residence, University Health AKey to symbols P PD i Permit Parking Metered Parking Parking for people with Disabilities Emergency for people with disabilities Emergency "Code Blue" Phone B120 B120B120 B120 E280E280 E200 C382C382 C640 D640

Keselj, Vlado

170

Transforming Parks and Protected Areas  

E-print Network

Transforming Parks and Protected Areas Policy and governance in a changing world Edited by Kevin S, and D. Scott Siocombe. p. em. 1. Protected areas - Management. 2. Parks - Mangement. 3. Protected areas areas Lisa M. Campbell, Noella J. Gray; and Zoe A. Meletis In many countries, parks and protected areas

Bolch, Tobias

171

Key to symbols Permit Parking  

E-print Network

Key to symbols P PD Permit Parking Metered Parking Parking for people with Disabilities Emergency are labelled both by name and letter (which appears in brackets in the listings where appropriate). J500 M.M. O Sexton House (E) J250 Chemical Engineering (F) J280 G.H. Murray Building (G) J301-02 Ralph M. Medjuck

Beaumont, Christopher

172

Astronomy in the National Parks  

NASA Astrophysics Data System (ADS)

American national parks are fertile grounds for astronomy and planetary science outreach. They are some of the last remaining dark-sky sites the typical visitor (both U.S. and international) can still experience easily. An internal National Park Service (NPS) study shows a dark starry sky is an integral part of what visitors consider their park experience. As a result, the NPS Night Sky Team (a coordinated group of park rangers and astronomers) is measuring and monitoring the sky brightness over the parks in an attempt to promote within the park service protection of the night sky as a natural resource. A number of parks (e.g. Grand Canyon National Park) are currently expanding their night sky related visitor programs in order to take advantage of this resource and visitor interest. The national parks and their visitors are therefore an ideal audience fully "primed” to learn about aspects of astronomy or planetary science that can be, in any way, associated with the night sky. As one of the astronomers on the NPS Night Sky Team, I have been working with park service personnel on ways to target park visitors for astronomical outreach. The purpose of this outreach is twofold: 1) Strengthen popular investment in preserving dark skies, 2) Strengthen popular investment in current astronomical research. A number of avenues already being used to introduce astronomy outreach into the parks (beyond the simple "star party") will be presented.

Nordgren, Tyler E.

2009-01-01

173

Geology Fieldnotes: Catoctin Mountain Park, Maryland  

NSDL National Science Digital Library

This site contains Catoctin Mountain Park information, a park map, and visitor information. A general cultural history of the park is given, from the first human inhabitants to its development into a park. Also mentioned are recreational attractions and Cunningham Falls State Park, located next to Catoctin. This park lies in the Appalachian Mountain chain.

174

Local Mass Media Communication and Environmental Disputes: An Analysis of Press Communication on the Designation of the Tuscan Archipelago National Park in Italy  

Microsoft Academic Search

The role of mass media in the construction of debated environmental issues is discussed, with reference to biodiversity conservation policies. The articles in a local daily newspaper (Il Tirreno) about the designation of the Tuscan Archipelago National Park in Italy have been content analyzed, before and after the park designation. In a quantitative study, two lexical correspondence analyses were conducted,

Giuseppe Carrus; Francesca Cini; Marino Bonaiuto; Alessandra Mauro

2009-01-01

175

Parks or Prisons?  

ERIC Educational Resources Information Center

Presents a simulation activity in which students assume the role of grizzly bears in Banff National Park. Concepts such as species diversity, fitness, natural selection, habitat loss, extinction, and population dynamics are discussed. Children learn how human activities can affect the bear's reproductive success. Lists materials, instructional…

Thomson, Gareth

1998-01-01

176

Forman Park University Pl  

E-print Network

NTOW N 5 FORM AN PARK 6 7 W ashington Street Fayette Street Genesee & Irving Street University 18. Landmark Theatre 19. Salina Street 20. S.ALT City Mural 21. Hanover Square 22. Storefront:Syracuse Design Center 23. Erie Canal Museum 24. City Hall 25. Jazz Central / CNY Jazz / Rarely Done Productions

Mather, Patrick T.

177

visitor parking rice village  

E-print Network

. mandellst. 6 7 8 9 10 11121314 17 18 19 1516 bus stop G 1 C B AG 2 3 4 5 26 24 intramural field 1 (rugby field) intramural fields 2 and 3 intramural field 6 intramural field 7 intramural field 5 practice field 22 76 21 5042 39 11 81 jake hess tennis stadium morningside track/soccer stadium reckling park

Alvarez, Pedro J.

178

The Clover Park Story  

ERIC Educational Resources Information Center

Describes an aviation trades training program offered by the Clover Park schools in Washington which exposes students to all facets of the aviation industry from record keeping to air traffic control in addition to the specific skill of piloting the aircraft. (BR)

Norris, Don

1974-01-01

179

GOLER HOUSE/ WHIPPLE PARK  

E-print Network

permits will not be allowed in the Goler House lot with the exception of the short-term spaces. Short-term spaces will be "30 minutes with flasher" parking ONLY for unloading pur- poses. Violators will be subject know your pick-up location when you call. Please be aware that shuttle response times may vary

Mahon, Bradford Z.

180

Exploring Jurassic Park.  

ERIC Educational Resources Information Center

Describes several student-tested activities built around "Jurassic Park." The activities feature students engaged in role-playing scenarios, investigative research projects, journal writing and communications skills activities, cooperative learning groups, and learning experiences that make use of reading skills and mathematical knowledge. (PR)

Simmons, Patricia E.; Wiley, Clyde

1993-01-01

181

Interleukin17 family and IL17 receptors  

Microsoft Academic Search

Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human genome sequencing and proteomics five additional members have been identified and cloned: IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The cognate

T. A. Moseley; D. R. Haudenschild; L. Rose; A. H. Reddi

2003-01-01

182

PARK(ing) Day 2011: Parking spaces around the globe to be temporarily reclaimed for people  

E-print Network

-based art and design studio, PARK(ing) Day challenges people to rethink the way streets are used's Matthew Passmore. "The planning strategies that generated these conditions are not sustainable, nor do

Saskatchewan, University of

183

A low diffusive Lagrange-remap scheme for the simulation of violent ai-water free-surface flows  

NASA Astrophysics Data System (ADS)

In 2002, Després and Lagoutière [17] proposed a low-diffusive advection scheme for pure transport equation problems, which is particularly accurate for step-shaped solutions, and thus suited for interface tracking procedure by a color function. This has been extended by Kokh and Lagoutière [28] in the context of compressible multifluid flows using a five-equation model. In this paper, we explore a simplified variant approach for gas-liquid three-equation models. The Eulerian numerical scheme has two ingredients: a robust remapped Lagrange solver for the solution of the volume-averaged equations, and a low diffusive compressive scheme for the advection of the gas mass fraction. Numerical experiments show the performance of the computational approach on various flow reference problems: dam break, sloshing of a tank filled with water, wate-water impact and finally a case of Rayleigh-Taylor instability. One of the advantages of the present interface capturing solver is its natural implementation on parallel processors or computers. wave formation and wave breaking; wall wave impacts, local pressure peaks and pressure loadings; formation of air pockets; ejection, fragmentation of liquid droplets; Archimedes buoyancy effect with rising of bubbles and fall of droplets; effects of gas compressibility inducing a gas-to-liquid response by a pressure wave, etc. In this paper, we consider immiscible gas-liquid two-phase flow problems. The strong ratio of mass density between gas and liquid (typically 1:1000) is known to be a source of numerical stiffness and numerical instability. Therefore robust computational approaches supporting high density ratio have to be considered. Among the family of conservative Finite Volume methods (FVM), the Lagrange-remapped solvers (see e.g. [42,45,6,4,25,2]) provide both robustness and stability with achievement of mathematical properties of positiveness and entropy compatibility.Lagrange-remap numerical schemes (also referred to as Eule-Lagrange schemes) are a particular family of Eulerian FVM where, at each time step, the equations are solved according to a Lagrangian evolution with a mesh that is convected by the flow itself, then the "Lagrange solutions" are remapped on the initial mesh into a conservative way by estimating both fluxed mass and momentum. Because of the Lagrangian step of these methods, code coupling or coupling of different physics is made easier against conventional FV methods. Moreover, the Lagrangian description is very practical for multi-material flows of multi-phase flows because we are a natural control of the fluxed quantities material-by-material. Lagrange and Lagrange-remap solvers still know strong developments today with major contributions as e.g. energy-preserving compatible schemes for staggered methods [11], collocated variables and cell-centered entropy-satisfying schemes, see [18,32,12].In this paper, we rather consider a simpler staggered Lagrange-remap solver with a direction-by-direction remapping. More precisely, the 2D multidimensional Lagrange step (operator Lxy?t) completely solves the fluid equations while an operator splitting alternating direction (AD) for the projection (operators Rx and Ry respectively) is used to interpolate on the reference Cartesian Eulerian grid into a conservative manner, involving convective flux balances. Symmetrized operator splitting can be used to ensure second order accuracy. Both linear and nonlinear numerical stabilities are ensured by the use of standard pseudo-viscosity (viscous pressure) terms, detailed into Appendix B at the end of this paper. Actually, we use this simple Euler solver because of its simplicity of code implementation and because it can be vectorized/parallelized into a natural manner. Moreover, the aim of this paper is not about the hydrodynamics solver: the article mostly focuses on numerical antidiffusive methods for interface capturing, as part of a global multifluid hydrodynamics solver. At the present time, the antidiffusive approaches assume a direction-by-direction remapping whic

Bernard-Champmartin, Aude; De Vuyst, Florian

2014-10-01

184

Yellowstone National Park  

NSDL National Science Digital Library

Yellowstone National Park was established on March 1, 1872, as the first national park in the world. The overwhelming and unique beauty found in this natural wonder is truly difficult to describe.This Topic In Depth begin with the excellent National Park Service's (1) official Yellowstone Web Site, which contains the park's history, virtual field trips, park information, visitor guides, web cams, kids pages, and more. The next site offered by EarthTalk Studios is called Yellowstone Geographic. This extensive and graphically reliant site contains superb interactive activities related to the park and comes close to its goal of being "the best Yellowstone Web Site on the planet." The third site from UnMuseum.org called Weird Geology: Geysers explores the workings of Yellowstone's famous geysers with descriptions, photographs, illustrations, and a movie of an eruption. The next site from Exploratorium is a learning activity called Geyser: Cyclic Hot Water Fountain. With the help of their teacher, students build a working model of a geyser from common chemical equipment. From the University of Michigan, Meg Streepey's Geysers and the Earth's Plumbing Systems Web Site describes (for more advanced students) how geysers work, including how to analyze their thermal and hydrologic regimes. Another research site, from the University of Utah's College of Mines and Earth Sciences, is the GPS Surveys of the Yellowstone Hotspot and the Wasatch Fault, Utah. Objectives of the study are "to measure and understand the spatial and temporal variations of the crustal deformation produced by the interaction between lithospheric plate motion and the asthenospheric hotspot." The last two sites are from the USGS, the first of which is the Yellowstone River Basin National Water-Quality Assessment Program site. It contains a project description, available data, and other relevant information. The last site, Yellowstone Volcano Observatory, is a facility that is designed for observing volcanic and earthquake activity in the park. This site also contains a project description, volcanic data, maps, descriptions of volcanic rock, a frequently asked questions link, and more.

Brieske, Joel A.

2002-01-01

185

USGS: Geology in the Parks  

NSDL National Science Digital Library

The US Geological Survey Geology in the Parks Web site is a cooperative project of the USGS Western Earth Surface Processes Team and the National Park Service. This extensive site covers geologic maps, plate tectonics, rocks and minerals, geologic time, US geologic provinces, park geology of the Mojave, Sunset Crater, Lake Mead, North Cascades, Death Valley, Yosemite National Park, and much more. Descriptions, graphics, photographs, and animations all contribute to this informative and interesting Web site making it a one stop, all encompassing, resource for everything geology and US national park related.

186

IL-4 and IL-13 modulate IL-10 release in endotoxin-stimulated murine peritoneal mononuclear phagocytes.  

PubMed

Several recent reports presented conflicting data on the action of IL-4 and IL-13 in regulating the release of proinflammatory cytokines by human monocytes. Here we show that the regulation of cytokine release by IL-4 and IL-13 could be either inhibitory or stimulatory in LPS-treated murine peritoneal macrophages. When macrophages were treated with IL-13 or IL-4, between 6 and 24 hr prior to endotoxin challenge, TNF alpha and IL-6 levels were significantly augmented. On the other hand, when the cells were cotreated with LPS plus IL-13 or IL-4, the release of TNF alpha and IL-6 was inhibited. These effects of IL-4 and IL-13 were associated with the modulation of IL-10; pretreatment resulted in a decrease, whereas cotreatment gave rise to a dramatic increase in IL-10 levels. The inhibitory effect of IL-4 and IL-13 on the release of TNF alpha was partially reversed by neutralizing anti-IL10 antibody, and the inhibition of IL-6 release was completely reversed by the antibody. These data suggest that the mechanism of action of IL-13 and IL-4 in modulating macrophage TNF alpha and IL-6 release partially involves IL-10. PMID:8660851

Kambayashi, T; Jacob, C O; Strassmann, G

1996-07-10

187

Mars parking orbit selection  

NASA Technical Reports Server (NTRS)

For a Mars mission, the selection of a parking orbit is greatly influenced by the precession caused by the oblateness of the planet. This affects the departure condition for earth return, and therefore, the mass required in LEO for a Mars mission. In this investigation, minimum LEO mass penalties were observed for parking orbits characterized by having near-equatorial inclinations, high eccentricities, and requiring a three-dimensional departure burn. However, because near-equatorial inclination orbits have poor planetary coverage characteristics, they are not desirable from a science viewpoint. To enhance these science requirements along with landing-site accessibility, a penalty in initial LEO mass is required. This study shows that this initial LEO mass penalty is reduced for orbits characterized with low to moderate eccentricities, nonequatorial inclinations, and a tangential periapsis arrival and departure burn.

Desai, Prasun N.; Braun, Robert D.

1990-01-01

188

Lincoln Park Architectural Photographs  

NSDL National Science Digital Library

The Lincoln Park neighborhood in Chicago is home to a number of architectural landmarks, including 19th century mansions with bold mansard roofs, a former seminary on the grounds of DePaul University, and other delights. In 2000, DePaul sociologist Wanda Harold set out to photograph a number of these unique structures. This digital collection includes 200 of her images, and this project was made possible in part through a grant from the Library Services and Technology Act. First-time visitors can get started by using a clickable map of Lincoln Park to explore the photos, and they can also browse around by architect or street. Visitors shouldn't miss the photos of the workers' cottages at 1756 N. Clybourn and 2715 N. Kenmore Avenue. Overall, the site is a nice resource for students of Chicago architecture and urban geography.

Harold, Wanda

2012-01-13

189

Predicting the safe load on backpacker's arm using Lagrange multipliers method  

NASA Astrophysics Data System (ADS)

In this study, a technique has been suggested to reduce a backpack load by transmitting determined loads to the children arm. The purpose of this paper is to estimate school children arm muscles while load carriage as well as to determine the safe load can be carried at wrist while walking with backpack. A mathematical model, as three DOFs model, was investigated in the sagittal plane and Lagrange multipliers method (LMM) was utilized to minimize a quadratic objective function of muscle forces. The muscle forces were minimized with three different load conditions which are termed as 0-L=0 N, 1-L=21.95 N, and 2-L=43.9 N. The investigated muscles were estimated and compared to their maximum forces throughout the load conditions. Flexor and extensor muscles were estimated and the results showed that flexor muscles were active while extensor muscles showed inactivity. The estimated muscle forces were didn't exceed their maximum forces with 0-L and 1-L conditions whereas biceps and FCR muscles exceeded their maximum forces with 2-L condition. Consequently, 1-L condition is quiet safe to be carried by hand whereas 2-L condition is not. Thus to reduce the load in the backpack the transmitted load shouldn't exceed 1-L condition.

Abdalla, Faisal Saleh; Rambely, Azmin Sham

2014-09-01

190

Lagrange Discrete Ordinates: a new angular discretization for the three dimensional linear Boltzmann equation  

E-print Network

The classical $S_n$ equations of Carlson and Lee have been a mainstay in multi-dimensional radiation transport calculations. In this paper, an alternative to the $S_n$ equations, the "Lagrange Discrete Ordinate" (LDO) equations are derived. These equations are based on an interpolatory framework for functions on the unit sphere in three dimensions. While the LDO equations retain the formal structure of the classical $S_n$ equations, they have a number of important differences. The LDO equations naturally allow the angular flux to be evaluated in directions other than those found in the quadrature set. To calculate the scattering source in the LDO equations, no spherical harmonic moments are needed--only values of the angular flux. Moreover, the LDO scattering source preserves the eigenstructure of the continuous scattering operator. The formal similarity of the LDO equations with the $S_n$ equations should allow easy modification of mature 3D $S_n$ codes such as PARTISN or PENTRAN to solve the LDO equations. ...

Ahrens, Cory D

2014-01-01

191

Free-Lagrange simulations of the expansion and jetting collapse of air bubbles in water  

NASA Astrophysics Data System (ADS)

A free-Lagrange numerical method is implemented to simulate the axisymmetric jetting collapse of air bubbles in water. This is performed for both lithotripter shock-induced collapses of initially stable bubbles, and for free-running cases where the bubble initially contains an overpressure. The code is validated using two test problems (shock-induced bubble collapse using a step shock, and shock10 MPa tensile waves, interacts with a bubble of initial radius 0.04 mm located in a free field (case 1) and near a rigid boundary (case 2). The interaction of the shock with the bubble causes it to involute and a liquid jet is formed that achieves a velocity exceeding 1.2 km s1 for case 2. The impact of the jet on the downstream wall of the bubble generates a blast wave with peak overpressure exceeding 1 GPa and 1.75 GPa for cases 1 and 2, respectively. The results show that the simulation technique retains sharply resolved gas/liquid interfaces regardless of the degree of geometric deformation, and reveal details of the dynamics of bubble collapse. The effects of compressibility are included for both liquid and gas phases, whereas stress distributions can be predicted within elastic-plastic solid surfaces (both planar and notched) in proximity to cavitation events. There is a movie with the online version of the paper.

Turangan, C. K.; Jamaluddin, A. R.; Ball, G. J.; Leighton, T. G.

192

Extrasolar planetary dynamics with a generalized planar Laplace-Lagrange secular theory  

E-print Network

The dynamical evolution of nearly half of the known extrasolar planets in multiple-planet systems may be dominated by secular perturbations. The commonly high eccentricities of the planetary orbits calls into question the utility of the traditional Laplace-Lagrange (LL) secular theory in analyses of the motion. We analytically generalize this theory to fourth-order in the eccentricities, compare the result with the second-order theory and octupole-level theory, and apply these theories to the likely secularly-dominated HD 12661, HD 168443, HD 38529 and Ups And multi-planet systems. The fourth-order scheme yields a multiply-branched criterion for maintaining apsidal libration, and implies that the apsidal rate of a small body is a function of its initial eccentricity, dependencies which are absent from the traditional theory. Numerical results indicate that the primary difference the second and fourth-order theories reveal is an alteration in secular periodicities, and to a smaller extent amplitudes of the planetary eccentricity variation. Comparison with numerical integrations indicates that the improvement afforded by the fourth-order theory over the second-order theory sometimes dwarfs the improvement needed to reproduce the actual dynamical evolution. We conclude that LL secular theory, to any order, generally represents a poor barometer for predicting secular dynamics in extrasolar planetary systems, but does embody a useful tool for extracting an accurate long-term dynamical description of systems with small bodies and/or near-circular orbits.

Dimitri Veras; Philip J. Armitage

2007-03-05

193

A Lagrange-D'Alembert formulation of the equations of motion of a helicopter carrying an externally suspended load  

NASA Technical Reports Server (NTRS)

The exact nonlinear equations of motion are derived for a helicopter with an extenal load suspended by fore and aft, rigid-link cables. Lagrange's form of D'Alembert's principle is used. Ten degrees of freedom are necessary to represent the motion of this system in an inertial reference frame: six for the helicopter relative to inertial space and four for the load relative to the helicopter.

Weber, J. M.; Greif, R. K.

1985-01-01

194

IL15R? Recycles and Presents IL15 In trans to Neighboring Cells  

Microsoft Academic Search

We report intriguing aspects of the contribution of IL-15R? to IL-15 functions. Consistent with high-affinity interactions between IL-15 and IL-15R?, these two molecules form stable complexes on the cell surface of activated monocytes. The formation of IL-15\\/IL-15R? complexes on cell surfaces induces a trans-endosomal recycling of IL-15 leading to the persistence of surface-bound IL-15 due to the constantreappearance of IL-15

Sigrid Dubois; Jennifer Mariner; Thomas A Waldmann; Yutaka Tagaya

2002-01-01

195

Fluid-structure interaction in the Lagrange-Poincare formalism: the Navier-Stokes and inviscid regimes  

E-print Network

In this paper, we derive the equations of motion for an elastic body interacting with a perfect fluid via the framework of Lagrange-Poincare reduction. We model the combined fluid-structure system as a geodesic curve on the total space of a principal bundle on which a diffeomorphism group acts. After reduction by the diffeomorphism group we obtain the fluid-structure interactions where the fluid evolves by the inviscid fluid equations. Along the way, we describe various geometric structures appearing in fluid-structure interactions: principal connections, Lie groupoids, Lie algebroids, etc. We finish by introducing viscosity in our framework as an external force and adding the no-slip boundary condition. The result is a description of an elastic body immersed in a Navier-Stokes fluid as an externally forced Lagrange-Poincare equation. Expressing fluid-structure interactions with Lagrange-Poincare theory provides an alternative to the traditional description of the Navier-Stokes equations on an evolving domain.

Henry O. Jacobs; Joris Vankerschaver

2012-12-05

196

IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1.  

PubMed

Central nervous system (CNS) autoimmunity is regulated by the balance of pro-inflammatory cytokines and IL-10. Here we identify the transcriptional regulator Blimp1 as crucial to induce IL-10 in inflammatory T helper cells. Pre-committed Th17 cells respond to IL-27 and IL-12 by upregulating Blimp1 and adopt a Tr-1-like phenotype characterized by IL-10 and IFN-? production. Accordingly, Blimp1-deficient effector T cells fail to produce IL-10, and deficiency in Tr-1 cell function leads to uncontrolled Th17 cell-driven CNS pathology without the need to stabilize the Th17 phenotype with IL-23. IL-23 counteracts IL-27 and IL-12-mediated effects on Tr-1-development reinforcing the pro-inflammatory phenotype of Th17 cells. Thus, the balance of IL-23 vs IL-12/IL-27 signals into CD4(+) effector T cells determines whether tissue inflammation is perpetuated or resolves. PMID:24796719

Heinemann, Christina; Heink, Sylvia; Petermann, Franziska; Vasanthakumar, Ajithkumar; Rothhammer, Veit; Doorduijn, Elien; Mitsdoerffer, Meike; Sie, Christopher; Prazeres da Costa, Olivia; Buch, Thorsten; Hemmer, Bernhard; Oukka, Mohamed; Kallies, Axel; Korn, Thomas

2014-01-01

197

Stroke, IL-1ra, IL1RN, Infection and Outcome  

PubMed Central

Background Infection is common following stroke and adversely affects outcome. Previous studies suggest that interleukin-1 receptor antagonist (IL-1ra) and single nucleotide polymorphisms (SNPs) in the IL1RN gene might influence the risk of post-stroke infection and outcome. In this study, we addressed the effects of the rs4251961 SNP in IL1RN on infection risk and outcome. Methods Subjects with acute ischemic stroke were enrolled within 72 hours of symptom onset and followed up to one year. Plasma IL-1ra was measured at multiple time points and outcome assessed at 1, 3, 6, and 12 months. Active surveillance for infection occurred while subjects were hospitalized. Subjects were genotyped for the IL1RN rs4251961 polymorphism. Results In this population of 113 subjects, those with the minor C allele of rs4251961 polymorphism in IL1RN were more likely to be Caucasian, hypertensive and to have coronary heart disease. Higher plasma IL-1ra was associated with an increased risk of infection (other than pneumonia) and the minor C allele of rs4251961 was independently associated with a decreased risk of infection (other than pneumonia). Initial plasma IL-1ra was not predictive of long term outcome, but patients with the minor C allele of rs4251961 were more likely to experience good (modified Rankin Score <2) long-term outcome. Conclusions These data indicate that IL-1ra and IL1RN may influence the risk of infection after stroke, but this influence seems limited to infections other than pneumonia. Further studies are needed to better understand the complexities of immune regulation on infection and outcome after stroke. PMID:24233813

Becker, Kyra J.; Dankwa, Dorender; Lee, Richard; Schulze, Juliane; Zierath, Dannielle; Tanzi, Patricia; Cain, Kevin; Dressel, Alexander; Shibata, Dean; Weinstein, Jonathan

2014-01-01

198

IL-1? Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity  

PubMed Central

Approximately 2 billion people currently suffer from intestinal helminth infections, which are typically chronic in nature and result in growth retardation, vitamin A deficiency, anemia and poor cognitive function. Such chronicity results from co-evolution between helminths and their mammalian hosts; however, the molecular mechanisms by which these organisms avert immune rejection are not clear. We have found that the natural murine helminth, Heligmosomoides polygyrus bakeri (Hp) elicits the secretion of IL-1? in vivo and in vitro and that this cytokine is critical for shaping a mucosal environment suited to helminth chronicity. Indeed in mice deficient for IL-1? (IL-1??/?), or treated with the soluble IL-1?R antagonist, Anakinra, helminth infection results in enhanced type 2 immunity and accelerated parasite expulsion. IL-1? acts to decrease production of IL-25 and IL-33 at early time points following infection and parasite rejection was determined to require IL-25. Taken together, these data indicate that Hp promotes the release of host-derived IL-1? that suppresses the release of innate cytokines, resulting in suboptimal type 2 immunity and allowing pathogen chronicity. PMID:23935505

Zaiss, Mario M.; Maslowski, Kendle M.; Mosconi, Ilaria; Guenat, Nadine; Marsland, Benjamin J.; Harris, Nicola L.

2013-01-01

199

41 CFR 102-74.270 - Are vehicles required to display parking permits in parking facilities?  

Code of Federal Regulations, 2013 CFR

...required to display parking permits in parking facilities? When the use of parking space is controlled as in § 102-74...authorized to use designated visitor or service areas must display a parking permit. This requirement may be...

2013-07-01

200

41 CFR 102-74.270 - Are vehicles required to display parking permits in parking facilities?  

Code of Federal Regulations, 2012 CFR

...required to display parking permits in parking facilities? When the use of parking space is controlled as in § 102-74...authorized to use designated visitor or service areas must display a parking permit. This requirement may be...

2012-01-01

201

Geology of the National Parks  

NSDL National Science Digital Library

This resource provides information about United States Geological Survey (USGS) resources and activities associated with National Parks. Users can choose from a selection of links that access items on park geology, virtual trips, research projects, and general topics such as plate tectonics, rocks and minerals, shorelines, glaciers, and many more. Links to geologic information for individual parks are arranged by alphabet, by state, or by geologic province.

202

Geology of Badlands National Park  

NSDL National Science Digital Library

This page is an introduction to the 75 million years of accumulation and intermittent periods of erosion that has resulted in the Badlands National Park. The history of the Oglicene beds of the Park, one of the world's richest vertebrate fossil sites, is also described. A downloadable PDF that describes the erosion that is responsible for the geology of the Park in more detail is linked to the site.

National Park Service (NPS)

203

National Parks WebQuest  

NSDL National Science Digital Library

This web-based activity challenges students to use a variety of internet resources to learn about several dimensions of national parks. Each student's research assignment focuses on one component of a park, such as its history, biology, geology, or tourist appeal. Students must keep track of important points and their references. Once research is complete, students come together and teach each other about their specific research domain, culminating in a holistic understanding of the park features.

Phillip, Mrs.; Explorer, Knowledge N.

204

Parking Services Rules and Regulations  

E-print Network

Parking Spaces 10 4.4 Lots/Areas Reserved for Events 10 4.5 Service Spaces 10 4.6 Loading/Unloading Zones.10 Encroachment 11 4.11 No Parking Area and Improper Uses 11 4.12 Prohibited Uses of Facilities 12 4.13 Abandoned as to ensure the proper and effective use and control of the available parking areas and facilities

Moore, Paul A.

205

Canyonlands National Park, UT, USA  

NASA Technical Reports Server (NTRS)

Desert and mountain scenery along the Utah/Colorado border are displayed in this scene of the Canyonlands National Park, UT (39.0N, 110.0W). The Park occuppies the near center of the image, displaying spectacular incised meanders and the bulls-eye structure of Upheaval Dome (a salt dome). The Green River and the Colorado River flow southward to join off scene before flowing through the Grand Canyon National Park.

1992-01-01

206

Canyonlands National Park, UT, USA  

NASA Technical Reports Server (NTRS)

Desert and mountain scenery along the Utah/Colorado border are displayed in this scene of the Canyonlands National Park, UT (39.0N, 110.0W). The park occupies the near center of the image, displaying spectacular incised meanders and the bulls-eye structure of Upheaval Dome (a salt dome). The Green River and the Colorado River flow southward to join (off scene) before flowing through the Grand Canyon National Park.

1973-01-01

207

Parking Options 2011/12 Reserved Permits  

E-print Network

issued a Commuter permit may park in any space in any yellow Commuter parking lot/area noted on the campus map. Commuter permits are restricted to yellow parking areas on the campus map, Monday through permits do not authorize parking outside of the Mines Park area. If residents prefer to drive to campus

208

February 2014 STUDENT APPLICATION FOR CAR PARKING  

E-print Network

and specified parking areas. Access Cards and Parking Permits are not transferable and are valid onlyFebruary 2014 STUDENT APPLICATION FOR CAR PARKING Car Parks Office Security & Portering Services (Campus Services Division) Park Place CARDIFF CF10 3AT Telephone: 029 2087 9092 Email: carparking

Davies, Christopher

209

February 2014 STAFF APPLICATION FOR CAR PARKING  

E-print Network

are issued in respect of named individuals and specified parking areas. Access Cards and Parking PermitsFebruary 2014 STAFF APPLICATION FOR CAR PARKING Car Parks Office Security & Portering Services (Campus Services Division) Park Place CARDIFF CF10 3AT Telephone: 029 2087 9092 Email: carparking

Davies, Christopher

210

Tour of Park Geology: Human Use Sites  

NSDL National Science Digital Library

This National Park Service (NPS) site provides links to geolgy field notes about National Parks, National Monuments, and National Recreation Areas having to do with geology and human use (such as mining). Information includes geology, photographs, multimedia tools, park maps, visitor information, geologic research, and additional links. Parks covered include Klondike Gold Rush National Historic Park, Alibates Flint Quarries National Monument, and more.

211

Tour of Park Geology: River Systems  

NSDL National Science Digital Library

This site provides links to National Parks, Monuments, Preserves, Rivers, and Recreation Areas with fluvial landforms. Park links provide maps, photographs, geologic and historical information, and teacher features (links for teaching tools). Parks in this category include Big Bend National Park, Canyonlands National Park, Buffalo National River, and more.

212

Terrein / car park: Inleveren bij / submit to  

E-print Network

Procedure: Terrein / car park: Inleveren bij / submit to: Info: Vul a.u.b. uw gegevens in / please terrein, voor de duur van: Requests access to the car park(s) mentioned above for the period of voorbehoud kan van toepassing zijn. You can request access rights for the local car park(s) on one campus

Galis, Frietson

213

The IL-23/IL-17 axis in psoriatic arthritis.  

PubMed

Psoriatic arthritis (PsA) is an immune-mediated chronic inflammatory disease, affecting both the skin and joints. Disease progression is associated with aberrant cytokine expression, and TNF blockade is the most successful therapy to date. However, not all patients are responsive to anti-TNF treatment, highlighting the need to better understand the cellular and molecular mechanisms that govern the disease. PsA associations with single nucleotide polymorphisms in IL23R as well as TRAF3IP2 (Act1), a molecule downstream of the IL-17 receptor (IL-17R), have linked the IL-23/IL-17 axis to disease pathology. Although both cytokines are implicated in PsA, a full picture of their cellular targets and pathogenic mechanisms has not yet emerged. In this review, we focus on the IL-23/IL-17 axis-elicited responses mediated by osteoclasts, keratinocytes and neutrophils. Expanding our understanding of the cellular and molecular mechanisms that dictate pathogenicity in PsA will contribute to developing novel treatment strategies to combat disease. PMID:24424175

Suzuki, Erika; Mellins, Elizabeth D; Gershwin, M Eric; Nestle, Frank O; Adamopoulos, Iannis E

2014-01-01

214

Optimized Expression of IL-12 Cytokine Family  

Cancer.gov

The IL-12 family of cytokines (IL-12, IL-23, and IL-27) plays a role in infection, inflammation and autoimmune diseases. IL-12 is produced by macrophages and dendritic cells in response to certain bacterial and parasitic infections and is a powerful inducer of IFN-gamma production.

215

A second row Parking Paradox  

E-print Network

We consider two variations of the discrete car parking problem where at every vertex of the integers a car arrives with rate one, now allowing for parking in two lines. a) The car parks in the first line whenever the vertex and all of its nearest neighbors are not occupied yet. It can reach the first line if it is not obstructed by cars already parked in the second line (screening). b) The car parks according to the same rules, but parking in the first line can not be obstructed by parked cars in the second line (no screening). In both models, a car that can not park in the first line will attempt to park in the second line. If it is obstructed in the second line as well, the attempt is discarded. We show that both models are solvable in terms of finite-dimensional ODEs. We compare numerically the limits of first and second line densities, with time going to infinity. While it is not surprising that model a) exhibits an increase of the density in the second line from the first line, more remarkably this is also true for model b), albeit in a less pronounced way.

S. R. Fleurke; C. Kuelske

2008-11-21

216

University of Aberdeen Car Parking Policy 1.0 Why have a car parking policy?  

E-print Network

space in designated staff parking areas. A permit or voucher does not guarantee a car parking space parking areas. A permit does not guarantee a car parking space. Permits are valid for one yearDocument1 University of Aberdeen Car Parking Policy 1.0 Why have a car parking policy

Pym, David J.

217

Chiltern Woodland Burial Park Chiltern Woodland Burial Park  

E-print Network

Chiltern Woodland Burial Park Chiltern Woodland Burial Park features natural materials and unique environmentally-friendly alternatives. Woodlands are naturally peaceful locations for `green burials' and in 2002 to the primary purpose of a natural burial site. Pitlands wood in Beaconsfield, Buckinghamshire, was selected due

218

Discovery Park Impact Network for Photovoltaic Technology  

E-print Network

Discovery Park Impact Network for Photovoltaic Technology NEED Discovery Park provides opportunities to create large-scale, interdisciplinary centers to address social challenges. One Discovery Park tool to facilitate interdisciplinary faculty collaborations is the Discovery Lecture Series, funded

Holland, Jeffrey

219

Traffic and Parking Services Financial Statements  

E-print Network

Traffic and Parking Services Financial Statements June 30, 2010 #12;FLORIDA ATLANTIC UNIVERSITY PARKING AND TRANSPORTATION SERVICES MANAGEMENT DISCUSSION AND ANALYSIS JUNE 30, 2010 Our discussion is healthy. The University's management, which oversees Parking & Transportation operations, has insured its

Fernandez, Eduardo

220

Acadia National Park Geologic Resources Inventory Report.  

National Technical Information Service (NTIS)

Arguably one of the most geologically remarkable sites along the Atlantic Coast, Acadia National Park represents the only National Park along the eastern seaboard with a coastline carved by Pleistocene continental glaciers. The parks landscape captures th...

2010-01-01

221

Designing for ecology : the ecological park  

E-print Network

This thesis aims to define a) what an ecological park is, and b) whether it is a new model in park design. Reference to the literature on landscape ecology is used to analyze the natural ecological merit of these parks, ...

Power, Andres M

2006-01-01

222

Geology Fieldnotes: Canyonlands National Park, Utah  

NSDL National Science Digital Library

This site contains park maps, visitor information, details about park geology, and a teacher feature (lessons for teaching science using National Park examples) for Canyonlands National Park in Utah. It discusses the creation of the canyons by the Green and Colorado rivers, as well as the geologic and human histories of the park. Also covered is information about the surrounding mountains (La Sals, Abajos, and Henry Mountains), the famous Upheaval Dome, The Maze, The Needles, and arches found within the park.

223

MIDDLE PARK Conservation Action Plan  

E-print Network

MIDDLE PARK Conservation Action Plan 2011 Update Plant Species of Focus: Kremmling milkvetch Panjabi, S. and B. Neely. 2011. Middle Park Conservation Action Plan, 2011 Update. Prepared by The Nature and threats by participants of an initial conservation action planning workshop held in June 2008 and a July

224

Roger Williams Park, Japanese Garden  

Microsoft Academic Search

Built in 1935-1936 by the Works Progress Administration in the 430 acre park designed by Horace Cleveland in 1878. The park itself is laid out in the romantic landscape tradition of Frederick Law Olmsted (1822-1903) and complements the asymmetry of the Japanese garden with its japonaise bridge and waterscape.

Chet Smolski

2011-01-01

225

California Community Colleges Parking Survey.  

ERIC Educational Resources Information Center

In 1990, a representative sample of 25 California community colleges was contacted by telephone to determine their parking policies and practices. The colleges were sampled on the basis of location and size. Study findings included the following: (1) 17 of the colleges reported that they had insufficient numbers of on-campus parking spaces; (2)…

McIntyre, Chuck

226

HOURGLASS FIRE Pingree Park Vicinity  

E-print Network

HOURGLASS FIRE Pingree Park Vicinity July 1-July 7, 1994 P.N. Omi Pingree Park overview, September, 1994, showing campus facilities in relation to area burned in the Houglass Fire. Summary narrative: The Hourglass Fire was first reported via 911 call to the Larimer County Sheriff on Friday, July 1 1994 at 10

227

Nevada Division of State Parks  

NSDL National Science Digital Library

Based in Carson City, the Nevada Division of State Parks helps to preserve and promote notable parts of the Nevada natural and cultural environment. One of the goals of their website is to provide visitors with "an introduction to the other side of Nevada, the side that is wild scenic and full of western history." First-time visitors may wish to click on the "State parks map" area to learn more about the location of the state parks, and the interactive map also includes direct links to each site. Scholars and students of park management will want to click on over to the "Park General and Resource Management Plans" area. Here they can learn about the completed general management plans for parks such as the Mormon Station and the Valley of Fire, and learn about plans that are currently under review. Visitors looking for helpful information about upcoming events can look over the "Other Park News!" area on the right hand side of the homepage. Finally, there's also detailed information about park fees, several photo galleries, and news releases.

228

Cardinal Soccer Clinic Peckham Park  

E-print Network

Cardinal Soccer Clinic at Peckham Park Middlefield, CT Dates: July 25-29, 2011 Time: 6:00-8:00 pm Who: Boys and Girls ­ Ages 5-12 (Grades K-6) Coaches: Geoff Wheeler ­ Wesleyan Men's Soccer Coach Why: Come enjoy a great week of soccer focused on individual skills, teamwork and fun! Where: Peckham Park

Devoto, Stephen H.

229

Traffic and Parking Financial Statements  

E-print Network

its financial health is improving or deteriorating. We believe that the financial position of TrafficTraffic and Parking Financial Statements June 30, 2009 #12;FLORIDA ATLANTIC UNIVERSITY TRAFFIC University's Traffic & Parking system financial performance provides an overview of the financial activities

Fernandez, Eduardo

230

Microbiology in Yellowstone National Park  

NSDL National Science Digital Library

This site describes how Yellowstone National Park is a focal point for cutting-edge microbiology research and how it provides a valuable setting for outreach education. Topics include questions for park officials, extremophiles, microbe diversity and evolution, educational outreach, and suggested reading.

David, Ward; University, Montana S.

231

Can Twitter save Bletchley Park?  

Microsoft Academic Search

Bletchley Park is the historic site of secret British codebreaking activities during World War II and birthplace of the modern computer. The work carried out there is said to have shortened WWII by two years, saving possibly 22 million lives. The Park is now a museum, with a 26 acre site, many exhibitions and working rebuilds of machines such as

Sue Black; Jonathan P. Bowen; Kelsey Griffin

2010-01-01

232

Science in the National Parks  

NSDL National Science Digital Library

This new addition to The National Park Service's website provides an overview of a huge array of research projects being conducted in US National Parks. Scientific studies are listed and summarized here (by Park), and include research on Nitrogen fixation, Neotropical migratory birds, meadow restoration, glacier research, and monitoring of wolf populations, to name a few. In addition, a list of Partners in Scientific Research is available at the site, as are current and archived copies of the agency's quarterly research and resource management bulletin Park Science. The exceptional value of the site is that it provides what most researchers don't have: detailed insights into different components (and scales) of the same ecosystem. Application procedures are included for those interested in conducting research at National Parks.

Service., United S.

233

IL-1 Effects in Brain.  

National Technical Information Service (NTIS)

This research explored the effect of cytokines and neurosteroids on the GABAergic and I glutamatergic neurotransmitter systems in the CNS. lnterleukin-1 (IL-1) augmented GABAA receptor function in behavioral, neurochemical and electrophysiological paradig...

L. G. Miller, J. M. Fahey

1997-01-01

234

Modulation of the IL-1 cytokine network in keratinocytes by intracellular IL-1 alpha and IL-1 receptor antagonist.  

PubMed Central

The IL-1 cytokine network in epidermal cells was studied in vitro, using the spontaneously transformed HaCAT human keratinocyte line. Intracellular (ic) IL-1 alpha and IL-1 receptor antagonist protein (IL-1Ra) following cell lysis were readily identified assayed using a capture ELISA; whereas in culture supernatants IL-1Ra was not detected, and IL-1 alpha was present at only very low levels. Confluent cultures of HaCAT cells were shown to provide optimal conditions for the study, since confluence increased the icIL-1Ra:IL-1 alpha ratio to a level as seen in vivo, which was independent of Ca2+ concentration in the culture medium. The IL-1Ra extracted from HaCAT cell lysates was functionally active, as demonstrated in the mouse thymocyte co-proliferation assay which could be blocked using a rabbit anti-IL-1Ra antibody. Transforming growth factor-beta (TGF-beta 1) stimulated a dose-dependent increase in HaCAT cell IL-1 alpha without changing IL-1Ra concentration, with a resultant reduction in the icIL-1Ra: IL-1 alpha ratio from 320:1 to 100:1. Similarly, TGF-alpha, interferon-gamma (IFN-gamma), IL-6, and tumour necrosis factor-alpha (TNF-alpha) substantially increased HaCAT cell IL-1 alpha, but had no effect on the IL-1Ra, with a concomitant reduction in the icIL-1Ra:IL-1 alpha ratio. In contrast to their effects on monocytes, IL-4 and IL-10 at biologically active levels had no effect on IL-1 alpha, IL-1Ra or the icIL-1Ra: IL-1 alpha ratio in confluent HaCAT cells. Hydrocortisone reduced IL-1 alpha to below the limit of sensitivity of the ELISA, and induced a small increase in IL-1Ra of questionable biological significance. Thus, regulation of the IL-1 cytokine network in keratinocytes involves modulation of icIL-1 alpha rather than of icIL-1Ra levels, and is markedly different from that noted in monocytes. PMID:7621586

Phillips, W G; Feldmann, M; Breathnach, S M; Brennan, F M

1995-01-01

235

Interleukin-4 (IL-4) Pathway  

NSDL National Science Digital Library

Interleukin-4 (IL-4) is a cytokine produced by TH2 type helper T cells and by mast cells, basophils, and eosinophils. This cytokine can elicit many responses, some of which are associated with allergy and asthma. Studies with long-term cell lines and primary cells have revealed differences in the signaling between these two experimental systems. Understanding these differences is important because therapeutic strategies targeting IL-4 and its signaling pathways are currently being tested to treat allergy and asthma.

Ann Kelly-Welch (University of Maryland and Stewart Greenebaum Cancer Center;Program in Oncology at Marlene and Department of Microbiology and Immunology REV); Erica M. Hanson (University of Maryland Baltimore County;Department of Biology REV); Achsah D. Keegan (University of Maryland and Stewart Greenebaum Cancer Center;Program in Oncology at Marlene and Department of Microbiology and Immunology REV)

2005-07-19

236

Amusement Park Physics  

NSDL National Science Digital Library

It's one thing to learn about physics in a lab, but it can be quite another thing to make a pilgrimage to an amusement park to take in the laws of physics. Users will have to supply their own corn dogs and popcorn, but this rather nice educational resource from Annenberg Media will be quite useful for budding physicists and their teachers. The resource allows users to design their own roller coaster, and along the way they will learn a thing or two about the laws of gravity, pendulums, and kinetic energy. Along with explanatory essays, this resource contains interactive graphics and a glossary of terms. Sit back and enjoy the virtual roller coaster ride, as this site provides a rather novel way of introducing students to physics.

237

Aftermath of Griffith Park Fire  

NASA Technical Reports Server (NTRS)

In mid-May 2007, wind-driven flames raced through Griffith Park in Los Angeles, forcing hasty evacuations and threatening numerous famous landmarks and tourist spots, such as the Los Angeles Zoo and the Hollywood Sign. Ultimately, no one was injured in the fire, which may have been started by a cigarette. About 800 acres burned in the urban park, which is itself a Hollywood landmark, having been the location for several movies, including Rebel Without A Cause. This image of the park was captured by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite on June 6, 2007, about a month after the fire. ASTER detects both visible and infrared wavelengths of light, and both kinds have been used to make this image. Vegetation appears in various shades of red, while the burned areas appear charcoal. Roads and dense urban areas appear purplish-gray or white. Water is dark blue. Large burned areas are evident in the northwest and southeast parts of the park, with scattered smaller patches along the southern margin. Some botanical gardens and parts of a bird sanctuary, as well as some park structures like restrooms, were destroyed. The park's unburned, natural vegetation appears brick red, while the irrigated golf courses adjacent to the park are bright red. NASA image created by Jesse Allen, using data provided courtesy of the NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.

2007-01-01

238

Chicago Public Library: Millennium Park  

NSDL National Science Digital Library

The transformation of the area east of Michigan Avenue from an industrial wasteland into the vibrant and heavily-used Millennium Park is truly a remarkable tale in Chicago's recent history. The apocryphal tale says that Mayor Richard M. Daley looked out from his dentist's office and envisioned a public park that would be comparable to other grand spaces in the city. The construction of Millennium Park took quite some time, but when the park was finished in 2004, most people were quite happy with it. This digital collection from the Chicago Public Library brings together over 5,100 images of the park at various phases of its construction. Visitors can view a highlights file of 154 images, and they can wander through topical areas like Cloud Gate, Crown Fountain, and Lurie Garden. Visitors interested in broad vistas of the entire setting should click on Full Park. Finally, visitors can use the tabs on the left-hand side of the page to look at architectural renderings and models of the park's various sections.

2012-03-16

239

Interleukin (IL)-13 and IL4 Are Potent Inhibitors of IL8 Secretion by Human Intestinal Epithelial Cells  

Microsoft Academic Search

Intestinal epithelial cells are able to producesoluble mediators that initiate or amplify inflammatoryevents in the intestinal mucosa. Interleukin (IL)-8 issuggested to be a cytokine playing a major role during the acute and chronic processes ininflammatory bowel disease (IBD). TH-2 cytokines havebeen described as down-regulating the inflammatoryresponse. We analyzed the effects of IL-10, IL-13, and IL-4 on IL-8 secretion in intestinalepithelial

Norbert Lugering; Torsten Kucharzik; Matthias Kraft; Gunther Winde; Clemens Sorg; Reinhard Stoll; Wolfram Domschke

1999-01-01

240

Park and chill : redesign parking garage in Hong Kong  

E-print Network

What are the aesthetics of urban infrastructure? Urban infrastructure has remained isolated to human activities. We all share memory and experience with urban infrastructure, e.g. we drive on the same roads and park our ...

Ting, Sze Ngai

2011-01-01

241

1.OA At the Park  

NSDL National Science Digital Library

This is a task from the Illustrative Mathematics website that is one part of a complete illustration of the standard to which it is aligned. Each task has at least one solution and some commentary that addresses important asects of the task and its potential use. Here are the first few lines of the commentary for this task: There were 7 children at the park. Then 4 more showed up. How many children were at the park all together? There were 7 children at the park. Some more...

242

Approfondimenti Il Coreper come organo cardine  

E-print Network

1 Approfondimenti Il Coreper come organo cardine del procedimento legislativo europeo Brevi responsabile della preparazione del lavoro del Consiglio e dell'esecuzione dei compiti che il Consiglio gli assegna». Il Trattato, affidando ad esso il compito della preparazione del Consiglio dei Ministri dell

Romeo, Alessandro

243

Yellowstone National Park: Historic 3-D Photographs Featuring Park Geology  

NSDL National Science Digital Library

This source provides a series of 34 historic photographs of well-known geologic landmarks in Yellowstone National Park. The photographs can be viewed individually or as part of a tour that begins at Old Faithful and proceeds in a clockwise route around the park. The images were created by digital manipulation of antique stereographs and they may be viewed as black and white photos or in 3-D using special stereographic glasses.

Phil, Stoffer; Team, Usgs W.

244

Teacher's Guide to Independence National Historical Park.  

ERIC Educational Resources Information Center

Independence National Historical Park, located in Philadelphia, Pennsylvania, is operated by the National Park Service. The park was authorized by an Act of Congress on June 28, 1948, and formally established on July 4, 1956. The mission of Independence National Historical Park is to preserve its stories, buildings, and artifacts as a source of…

National Park Service (Dept. of Interior), Philadelphia, PA. Independence National Historical Park.

245

Standard structures For roadside, car parks,  

E-print Network

Standard structures For roadside, car parks, visitor information, wayfinding & waymarking Forestry visitor centres. Suitable locations At road entrance to car park/driveway Symbols Up to 5 symbols is for Entrances to medium-sized car parks Suitable locations At road entrance to car park Symbols Up to 3 symbols

246

Person Tracking for Parking Space Vacancy Prediction  

Microsoft Academic Search

UCSD has a serious problem with undergraduate student parking. Most students must resort to parking in far corners of the campus and taking shuttle buses to their classes. When arriving at campus, people generally search for vacant parking spaces from the closest spaces to the farthest, unnecessarily wasting time. We propose a solution whereby students can determine whether a parking

Mooneer Salem

247

University of Minnesota Parking & Transportation Services  

E-print Network

problems with your keycard, please call the Parking and Transportation Services' office at 626-PARK as soon privileges are on a SPACE AVAILABLE BASIS ONLY. Also, reciprocal parking on the same campus as your assignedUniversity of Minnesota Parking & Transportation Services KEYCARD USER INFORMATION If you have any

Gulliver, Robert

248

Optimal parking orbits for manned Mars missions  

Microsoft Academic Search

This paper summarizes a Mars parking orbit optimization effort. This parking orbit study includes the selection of optimal elliptic Mars parking orbits that meet mission constraints and that include pertinent apsidal misalignment losses. Mars missions examined are for the opportunity years of 2014, 2016, and 2018. For these mission opportunities, it is shown that the optimal parking orbits depend on

Michael L. Cupples; Jill A. Nordwall

1993-01-01

249

Department of Public Safety Parking and  

E-print Network

posted). 6.4. Parking outside of color designated parking areas is allowed weekdays from 6 PM - 1 AMDepartment of Public Safety Parking and Traffic Regulations SY 2012-2013 Edition Department of Public Safety Administrative Services 419 Boston Avenue Medford, MA 02155 (617) 627-3692 Visit http://publicsafety.tufts.edu/parking

Dennett, Daniel

250

Man Sik Park Symmetry and Separability In  

E-print Network

Man Sik Park Symmetry and Separability In Spatial-Temporal Processes Man Sik Park, Montserrat Fuentes Symmetry and Separability In Spatial-Temporal Processes 1 #12;Man Sik Park Motivation · In general-pollution data. Symmetry and Separability In Spatial-Temporal Processes 2 #12;Man Sik Park Research Objectives 1

251

The international politics of national parks  

Microsoft Academic Search

National parks are the keystone institutions of environmental conservation. Because national parks make certain lands part of the state itself, international agencies and nongovernmental organizations that promote national parks propose, in effect, to alter the state, as well as the local economy and state relations with social groups. Has international political pressure caused states to create national parks? I consider

Karen M. O'Neill

1996-01-01

252

ParkSense: A Smartphone Based Sensing System For On-Street Parking  

E-print Network

if a driver has vacated a parking spot. ParkSense leverages the ubiquitous Wi-Fi beacons in urban areas. INTRODUCTION In metropolitan city centers and dense urban areas around the world, parking space is an expensiveParkSense: A Smartphone Based Sensing System For On-Street Parking Sarfraz Nawaz, Christos

Mascolo, Cecilia

253

University of Aberdeen Car Parking Policy -v2 0.docx University of Aberdeen Car Parking Policy  

E-print Network

in an available space in designated staff parking areas. A permit or voucher does not guarantee a car parking to search for and park in an available priority or standard space in designated staff parking areas. A permit entitles students to search for and park in an available space in designated areas matching

Levi, Ran

254

Criteria for Car Parking Allocation System Criteria for Car Parking Allocation System  

E-print Network

Criteria for Car Parking Allocation System Criteria for Car Parking Allocation System 2014-15 Criteria for Car Parking All #12;The issue and control of car parking permits is vested in Estates Services. The annual charges are incorporated in the application form. The car parking charges will be deducted from

Mottram, Nigel

255

Role of fibroblasts in the regulation of proinflammatory interleukin IL-1, IL-6 and IL-8 levels induced by keratinocyte-derived IL-1.  

PubMed

In the epidermis, the keratinocytes are the first cells to be encountered by external stimuli and they are able to promote the inflammatory response by increased production and release of various cytokines. In their turn, these cytokines may directly affect the production of proinflammatory cytokines in human dermal fibroblasts. In addition, in both epithelial and mesenchymal cells cytokine production may be modulated by their mutual interaction, and thereby regulate the inflammatory response. The present study aimed to examine the role of fibroblasts in the regulation of proinflammatory IL-1, IL-6 and IL-8 levels induced by keratinocyte-derived IL-1. The data show that in fibroblasts exposed to conditioned media derived from cultures of normal human keratinocytes or squamous carcinoma cells (SCC-4), both the IL-8 and IL-6 mRNA expression as well as protein production were elevated. In addition, it was shown that these effects were induced by IL-1 alpha. The IL-1 alpha-induced increase in IL-8 and IL-6 production, both on the protein level as well as on the mRNA level, were concentration dependent and occurred almost simultaneously. While the induction of IL-6 and IL-8 occurred simultaneously, the IL-6 mRNA remained elevated for longer. In contrast to increased IL-6 and IL-8 production the IL-1 alpha levels markedly decreased upon culturing of fibroblasts in keratinocyte-derived conditioned medium. From internalization experiments it could be concluded that binding of IL-1 to IL-1 receptors, and its subsequent internalization and intracellular degradation is the most likely mechanism involved in the reduction of IL-1 levels by fibroblasts. Comparing the rate of IL-1 reduction in the presence of various cell types indicated that the rate of IL-1 reduction is directly related to the number of IL-1 receptors found on these cell types. In conclusion, these results indicate that the release of IL-1 alpha by activated keratinocytes may act as an inducer of IL-8 and IL-6 production in neighbouring fibroblasts. This may be an important pathway for the amplification of the inflammatory response. The amounts of both cytokines produced by fibroblasts were at least two to three orders of magnitude higher than those produced by keratinocytes, suggesting an important role of fibroblasts in the general inflammatory response. Furthermore, fibroblasts might be involved in turning off this inflammatory response by reducing IL-1 levels, most likely via IL-1 receptor-mediated uptake. PMID:8818187

Boxman, I L; Ruwhof, C; Boerman, O C; Löwik, C W; Ponec, M

1996-06-01

256

Vandal-Proof Your Park.  

ERIC Educational Resources Information Center

Responses of 380 park maintenance and facility managers to a questionnaire provided information on how they try to prevent vandalism affecting signs, picnic and related services, and sanitary facilities. (CB)

Shattuck, J. Bruce

1988-01-01

257

Morris Park Ave Rhinelander Ave  

E-print Network

Albert Einstein College of Medicine ALBERT EINSTEIN COLLEGE OF MEDICINE JACK AND PEARL RESNICK CAMPUS Building 19. Einstein Boiler Plant JACOBI MEDICAL CENTER 20. Nurses' Residence MEDICAL PARK EINSTEIN PROGRAM LOCATIONS Glass Building Ob/Gyn Private Practice

Kenny, Paraic

258

Renovation proposal for Fenway Park  

E-print Network

As the oldest stadium in baseball history, the existing structure of Fenway Park presents problems such as limiting seating capacity and obstructed views, caused by the columns supporting the second level. Opened in 1912, ...

Aldana Urrutia, Luis Pedro

2009-01-01

259

Blue Spring State Park Immunization  

E-print Network

: Argentina Bangladesh Bolivia Brazil Burkina Faso Chile China Colombia Costa Rica Ecuador France Honduras September 23, 2013 #12;Korea Venezuela Manners and Culture Q: Why doesn't UF have more parking lots? A

Pilyugin, Sergei S.

260

Jurassic Park: Adventure in Learning.  

ERIC Educational Resources Information Center

Describes using the movie "Jurassic Park" as a foundation for a middle school interdisciplinary unit involving science, math, language arts, history, and geography. Suggested books and activities are presented. (PR)

Shams, Marcia; Boteler, Trina

1993-01-01

261

The Science Behind Jurassic Park  

NSDL National Science Digital Library

"The Science Behind Jurassic Park" is an html document describing how world renowned paleontologist Jack Horner is using computers and CAT scan machines to peer inside 30 million year old dinosaur fossils.

262

IL TRAPIANTO ORTOTOPICO DEL FEGATO  

PubMed Central

E’ormai noto che esiste la possibilità rivoluzionaria di utilizzare il fegato per il trattamento della stadio terminale delle epatopatie. Nel gennaio 1980 si celebra il decimo anna di sopravvivenza con fegato trapiantato (la più lunga della letteratura) di un paziente da noi trattato. Si tratta di uno dei 12 malati sottoposti a trapianto e seguiti per più di 5 anni. La nota positiva di questa tipo di trattamento è rappresentata dall’eccellente tenore di vita che i pazienti conducono e dalla riabilitazione sociale e professionale. La nota negativa è data, invece, dal fatto che i buoni risultati non vengono raggiunti con regolarità e non possono essere previsti con esattezza. In questa breve rassegna considereremo la esperienza da noi fatta presso l’Università di Denver nel Colorado, mettendo in risalto le cause dell’elevata mortalità precoce e le prospettive future di questa mezzo terapeutico. PMID:21572898

STARZL, THOMAS E.

2010-01-01

263

Evaluation of IL17A expression and of IL17A, IL17F and IL23R gene polymorphisms in Brazilian individuals with periodontitis.  

PubMed

The IL23/Th17 axis plays an important role in the pathogenesis of cell-mediated tissue damage caused either by autoimmunity or immune responses against bacterial infection. Single nucleotide polymorphisms in the IL17A, IL17F and IL23R genes have been associated with several inflammatory diseases. However, these polymorphisms have not yet been studied in periodontitis. The aim of present study was to evaluate the expression of IL17A and occurrence of the IL17A (rs2275913), IL17F (rs763780) and IL23R (rs11209026) gene polymorphisms in different clinical forms or severity of periodontitis in a sample of Brazilian individuals. Peripheral blood was obtained from 30 non-smoker individuals and analyzed by flow cytometry to determine IL-17 expression. Genomic DNA was obtained from oral swabs in 180 individuals and analyzed by Real-time PCR. The study group was composed by individuals without periodontitis (control), with aggressive periodontitis (AP) and with chronic periodontitis (CP). Higher frequency of IL17A+CD4+ T cells was observed in control group. The A+ genotype from IL17A (rs2275913) was associated with lack of disease. No association was found considering the IL17F and IL23R polymorphisms. Our data suggest that IL17A and the presence of IL17A (rs2275913) A allele are associated with the absence of periodontal disease. PMID:23137879

Saraiva, Adriana Machado; Alves e Silva, Micena Roberta Miranda; Correia Silva, Jeane de Fátima; da Costa, José Eustáquio; Gollob, Kenneth John; Dutra, Walderez Ornelas; Moreira, Paula Rocha

2013-02-01

264

Car-Park Occupancy Information System  

Microsoft Academic Search

Drivers always face difficulty of finding available parking lot while entering into a huge parking area. A Car-Park Occupancy Information System (COINS) is perhaps a viable solution to reduce the amount of time needed to search for a vacant car-park lot especially in a huge parking area. With this system, images captured by a surveillance camera were processed in real-time

D. B. L. Bong; K. C. Ting; N. Rajaee

265

IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling.  

PubMed

The cytokine IL-6 plays a protective role in immune responses against bacterial infections. However, the mechanisms of IL-6-mediated protection are only partially understood. IL-6 can signal via the IL-6R complex composed of membrane-bound IL-6R? (mIL-6R?) and gp130. Owing to the restricted expression of mIL-6R?, classical IL-6 signaling occurs only in a limited number of cells such as hepatocytes and certain leukocyte subsets. IL-6 also interacts with soluble IL-6R? proteins and these IL-6/soluble IL-6R? complexes can subsequently bind to membrane-bound gp130 proteins and induce signaling. Because gp130 is ubiquitously expressed, this IL-6 trans-signaling substantially increases the spectrum of cells responding to IL-6. In this study, we analyze the role of classical IL-6 signaling and IL-6 trans-signaling in the innate immune response of mice against Listeria monocytogenes infection. We demonstrate that L. monocytogenes infection causes profound systemic IL-6 production and rapid loss of IL-6R? surface expression on neutrophils, inflammatory monocytes, and different lymphocyte subsets. IL-6-deficient mice or mice treated with neutralizing anti-IL-6 mAb displayed impaired control of L. monocytogenes infection accompanied by alterations in the expression of inflammatory cytokines and chemokines, as well as in the recruitment of inflammatory cells. In contrast, restricted blockade of IL-6 trans-signaling by application or transgenic expression of a soluble gp130 protein did not restrain the control of infection. In summary, our results demonstrate that IL-6R? surface expression is highly dynamic during the innate response against L. monocytogenes and that the protective IL-6 function is dependent on classical IL-6 signaling via mIL-6R?. PMID:23241882

Hoge, Judith; Yan, Isabell; Jänner, Nathalie; Schumacher, Valéa; Chalaris, Athena; Steinmetz, Oliver M; Engel, Daniel R; Scheller, Jürgen; Rose-John, Stefan; Mittrücker, Hans-Willi

2013-01-15

266

Urban Parks: The Value of Small Urban Parks, Plazas and Other Outdoor Spaces  

E-print Network

People need parks. Great urban parks are places where communities come together, people interact, and social capital develops. Learn the characteristics of great urban parks and how they are created....

Shafer, Carl Scott; Jacob, John

2006-11-27

267

A novel functional rabbit IL- 7 isoform  

PubMed Central

IL-7 is required for B cell development in mouse and is a key regulator of T cell development and peripheral T cell homeostasis in mouse and human. Recently, we found that IL-7 is expressed in rabbit bone marrow and in vitro, is required for differentiation of lymphoid progenitors to B and T lineage cells. Herein, we report the identification of a novel rabbit IL-7 isoform, IL-7II. Recombinant IL-7II (rIL-7II) binds lymphocytes via the IL-7R and induces phosphorylation of STAT5. Further, rIL-7II supports proliferation and differentiation of BM progenitor cells into B and T lineage cells. IL7-II is generated by alternative splicing, with an 11 amino acid insertion encoded by a separate exon, exon 2b. Exon 2b is conserved in other lagomorphs, in Perissodactyla, Artiodactyla, and Carnivora, but is absent in mouse and human. PMID:20304004

Siewe, Basile T.; Kalis, Susan L.; Esteves, Pedro J.; Zhou, Tong; Knight, Katherine L.

2010-01-01

268

IL-21 induces IL-22 production in CD4+ T cells.  

PubMed

Interleukin (IL)-22 produced by innate lymphoid cells (ILCs) and CD4+ T cells plays an important role in host defence and mucosal homeostasis, thus it is important to investigate the mechanisms that regulate IL-22 production. We investigated the regulation IL-22 production by CD4+ T cells. Here we show that IL-21 triggers IL-22, but not IL-17 production by CD4+ T cells. STAT3, activated by IL-21, controls the epigenetic status of the il22 promoter and its interaction with the aryl hydrocarbon receptor (AhR). Moreover, IL-21 and AhR signalling in T cells control IL-22 production and the development of dextran sodium sulphate-induced colitis in ILC-deficient mice. Thus, we have identified IL-21 as an inducer of IL-22 production in CD4+ T cells in vitro and in vivo. PMID:24796415

Yeste, Ada; Mascanfroni, Ivan D; Nadeau, Meghan; Burns, Evan J; Tukpah, Ann-Marcia; Santiago, Andrezza; Wu, Chuan; Patel, Bonny; Kumar, Deepak; Quintana, Francisco J

2014-01-01

269

Quantitative analysis of IL-2 and IL-15 signal transduction in T lymphocytes  

E-print Network

IL-2 and IL-15 are common y-chain family cytokines critically involved in regulation of T cell differentiation and homeostasis. Both cytokines signal through a heterotrimeric surface receptor complex (IL-2/15R) composed ...

Arneja, Abhinav

2013-01-01

270

Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex  

SciTech Connect

IL-15 interacts with a heterotrimeric receptor that consists of the {beta} and {gamma} subunits of the IL-2 receptor (IL-2R) as well as a specific, high-affinity IL-15-binding subunit, which is designated IL-15R{alpha}. Since both the {beta} and the {gamma} subunits of the IL-2R are required for signaling by either IL-2 or IL-15, it is not surprising that these cytokines share many activities in vitro. However, the differential expression of these cytokines and the {alpha} chains of their receptors within various tissues and cell types suggests that IL-2 and IL-15 may perform at least partially distinct physiological functions. The production of IL-15 by macrophages, and possibly other cell types, in response to environmental stimuli and infectious agents suggests that IL-15 may play a role in protective immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. 56 refs.

Kennedy, M.K.; Park, L.S. [Immunex Corp., Seattle, WA (United States)

1996-05-01

271

IL-21 induces IL-22 production in CD4+ T-cells  

PubMed Central

IL-22 produced by innate lymphoid cells (ILCs) and CD4+ T cells plays an important role in host defense and mucosal homeostasis, thus it is important to investigate the mechanisms that regulate IL-22 production. We investigated the regulation IL-22 production by CD4+ T cells. Here we show that IL-21 triggers IL-22, but not IL-17 production by CD4+ T cells. STAT3, activated by IL-21, controls the epigenetic status of the il22 promoter and its interaction with the aryl hydrocarbon receptor (AhR). Moreover, IL-21 and AhR signaling in T cells control IL-22 production and the development of dextran sodium sulfate-induced colitis in ILC-deficient mice. Thus, we have identified IL-21 as an inducer of IL-22 production in CD4+ T cells in vitro and in vivo. PMID:24796415

Yeste, Ada; Mascanfroni, Ivan D.; Nadeau, Meghan; Burns, Evan J.; Tukpah, Ann-Marcia; Santiago, Andrezza; Wu, Chuan; Patel, Bonny; Kumar, Deepak; Quintana, Francisco J.

2014-01-01

272

Interleukin1 Type II Receptor: A Decoy Target for IL1 That Is Regulated by IL4  

Microsoft Academic Search

Interleukin-1 (IL-1) interacts with cells through two types of binding molecules, IL-1 type I receptor (IL-1R I) and IL-1R II. The function of IL-1R II is unknown. In studies using monoclonal antibodies, IL-1 prolonged the in vitro survival of polymorphonuclear cells (PMN) through IL-1R I, and IL-4 antagonized the action of IL-1 by inducing expression and release of IL-1R II.

Francesco Colotta; Fabio Re; Marta Muzio; Riccardo Bertini; Nadia Polentarutti; Marina Sironi; Judith G. Giri; Steven K. Dower; John E. Sims; Alberto Mantovani

1993-01-01

273

il mio paese Roman statesman  

E-print Network

#12;il mio paese #12;Roman statesman Gaius Gracchus, 153-121 B.C. The road builder His most special. From Plutarch's biography of Gracchus #12;Roman Roads Most Roman roads constructed during the Republican times (509 to 30 BC) ­ the oldest, Via Appia, dates back to 312 B.C. At its height, the Roman road

Ballarini, Roberto

274

Tumorigenicity of IL1?- and IL1?-Deficient Fibrosarcoma Cells1  

Microsoft Academic Search

Analyzing the growth of fibrosarcoma lines derived from IL-1?-, IL-1?- ,o rIL-1??-knockout (?\\/? )m ice in the immunocompetent host revealed that tumor-derived IL-1? and IL-1? exert strong and opposing effects on immune response induction, which prohibited the evaluation of a potential impact on tumorigenicity. Therefore, in vivo growth of IL-1-deficient tumor lines was evaluated in nu\\/nu mice and was compared

Irina Nazarenko; Rachid Marhaba; Eli Reich; Elena Voronov; Mario Vitacolonna; Dagmar Hildebrand; Elena Elter; Mohini Rajasagi; Ron N. Apte; Margot Zöller

275

Effects of Park Improvements on Park Use and Physical Activity Policy and Programming Implications  

PubMed Central

Background Many assume that improving the quality and the perceived safety of facilities in parks and recreation centers are critical to attracting more users and increasing population physical activity. There are few studies in which these assumptions have been tested. Purpose To assess the impact of park improvements on park use and physical activity. Methods Five intervention parks and five matched comparison parks were studied by objectively measuring park use and collecting self reports of park use by residents before and after park improvements. After using the System for Observing Play and Recreation in Communities (SOPARC) to count park users and measure their activity levels and conducting household interviews and intercept surveys with park users, propensity score analyses were used to adjust for differences in respondents’ characteristics between pre- and post-intervention and across conditions. Results Overall park use and physical activity declined in both intervention and control parks, with 39% of the decline directly attributable to fewer scheduled organized activities. Perceptions of park safety increased more in the intervention parks than in the comparison parks. Conclusions Improvements to parks may not automatically result in increased use and physical activity, especially when programming decreases. Multiple factors contribute to park use and need to be accounted for in future community-level interventions. Improving perceptions of safety alone are unlikely to result in increased park use. PMID:19944911

Cohen, Deborah; Golinelli, Daniela; Williamson, Stephanie; Sehgal, Amber; Marsh, Terry; McKenzie, Thomas L

2009-01-01

276

Parks and physical activity: Why are some parks used more than others?  

PubMed Central

Objective To assess how park characteristics and demographic factors are associated with park use. Methods We studied a diverse sample of parks in a Southern California metropolitan area in 2006–2008 representing a variety of racial and ethnic communities of different socioeconomic strata. We surveyed 51 park directors, 4257 park users and local residents, and observed 30 parks. We explored relationships among the number of people observed, the number of park programs offered, number of organized activities observed, park size, existence of park advisory board, perceptions of safety, and population density and characteristics. Results The strongest correlates of the number of people using the park were the park size and the number of organized activities observed. Neighborhood population density, neighborhood poverty levels, perceptions of park safety, and the presence of a park advisory board were not associated with park use. Conclusion While perceptions of low safety have been considered a barrier to park use, perceptions of high safety do not appear to facilitate park use. Having events at the park, including sports competitions and other attractions, appears to be the strongest correlate of park use and community-level physical activity. PMID:19850067

Cohen, Deborah; Marsh, Terry; Williamson, Stephanie; Derose, Kathryn Pitkin; Martinez, Homero; Setodji, Claude; McKenzie, Thom

2009-01-01

277

U-M DEPARTMENT PARKING APPLICATION Use this application to request department parking options (annual or Department Pre-Paid Daily Parking). Please read the policies for  

E-print Network

Parking -- Parking within walking distance of campus core areas or next to U-M buildings in remote areas-M buildings. Also honored in any Blue, Yellow or Orange parking area and at the Taubman Parking Structure2010­2011 U-M DEPARTMENT PARKING APPLICATION Use this application to request department parking

Kirschner, Denise

278

Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense.  

PubMed

Respiratory infections and diseases are among the leading causes of death worldwide, and effective treatments probably require manipulating the inflammatory response to pathogenic microbes or allergens. Here, we review mechanisms controlling the production and functions of interleukin-17 (IL-17) and IL-22, cytokines that direct several aspects of lung immunity. Innate lymphocytes (?? T cells, natural killer cells, innate lymphoid cells) are the major source of IL-17 and IL-22 during acute infections, while CD4(+) T-helper 17 (Th17) cells contribute to vaccine-induced immunity. The characterization of dendritic cell (DC) subsets has revealed their central roles in T-cell activation. CD11b(+) DCs stimulated with bacteria or fungi secrete IL-1? and IL-23, potent inducers of IL-17 and IL-22. On the other hand, recognition of viruses by plasmacytoid DCs inhibits IL-1? and IL-23 release, increasing susceptibility to bacterial superinfections. IL-17 and IL-22 primarily act on the lung epithelium, inducing antimicrobial proteins and neutrophil chemoattractants. Recent studies found that stimulation of macrophages and DCs with IL-17 also contributes to antibacterial immunity, while IL-22 promotes epithelial proliferation and repair following injury. Chronic diseases such as asthma and chronic obstructive pulmonary disease have been associated with IL-17 and IL-22 responses directed against innocuous antigens. Future studies will evaluate the therapeutic efficacy of targeting the IL-17/IL-22 pathway in pulmonary inflammation. PMID:24942687

McAleer, Jeremy P; Kolls, Jay K

2014-07-01

279

Recombinant p35 from Bacteria Can Form Interleukin (IL-)12, but Not IL-35  

PubMed Central

The Interleukin (IL)-12 family contains several heterodimeric composite cytokines which share subunits among each other. IL-12 consists of the subunits p40 (shared with IL-23) and p35. p35 is shared with the composite cytokine IL-35 which comprises of the p35/EBI3 heterodimer (EBI3 shared with IL-27). IL-35 signals via homo- or heterodimers of IL-12R?2, gp130 and WSX-1, which are shared with IL-12 and IL-27 receptor complexes, respectively. p35 was efficiently secreted in complex with p40 as IL-12 but not with EBI3 as IL-35 in several transfected cell lines tested which complicates the analysis of IL-35 signal transduction. p35 and p40 but not p35 and EBI3 form an inter-chain disulfide bridge. Mutation of the responsible cysteine residue (p40C197A) reduced IL-12 formation and activity only slightly. Importantly, the p40C197A mutation prevented the formation of antagonistic p40 homodimers which enabled the in vitro reconstitution of biologically active IL-12 with p35 produced in bacteria (p35bac). Reconstitution of IL-35 with p35bac and EBI3 did, however, fail to induce signal transduction in Ba/F3 cells expressing IL-12R?2 and gp130. In summary, we describe the in vitro reconstitution of IL-12, but fail to produce recombinant IL-35 by this novel approach. PMID:25259790

Aparicio-Siegmund, Samadhi; Moll, Jens M.; Lokau, Juliane; Grusdat, Melanie; Schroder, Jutta; Plohn, Svenja; Rose-John, Stefan; Grotzinger, Joachim; Lang, Philipp A.; Scheller, Jurgen; Garbers, Christoph

2014-01-01

280

A Novel Immunoregulatory Function for IL-23: Inhibition of IL-12 Dependent IFN-? Production  

PubMed Central

Summary Most studies investigating the function of IL-23 have concluded that it promotes IL-17 secreting T cells. While some reports have also characterized IL-23 as having redundant pro-inflammatory effects with IL-12, we have instead found that IL-23 antagonizes IL-12 induced secretion of IFN-?. When splenocytes or purified populations of T cells are cultured with IL-23, IFN-? secretion in response to IL-12 is dramatically reduced. The impact of IL-23 is most prominent in CD8 T cells, but is also observed in NK and CD4 T cells. Mechanistically, the IL-23 receptor is not required for this phenomenon, and IL-23 inhibits signaling through the IL-12 receptor by reducing IL-12 induced signal transducer and activator of transcription 4 (STAT4) phosphorylation. IL-23 is also able to reduce IFN-? secretion by antagonizing endogenously produced IL-12 from Listeria monocytogenes (LM) infected macrophages. In vivo, LM infection induces higher serum IFN-? levels and a greater percentage of IFN-?+CD8+ T cells in IL-23p19 deficient mice as compared to wild-type mice. This increase in IFN-? production coincides with increased LM clearance at days 2–3 post-infection. Our data suggest that IL-23 may be a key factor in determining the responsiveness of lymphocytes to IL-12 and their subsequent secretion of IFN-?. PMID:20458705

Sieve, Amy N.; Meeks, Karen D.; Lee, Suheung; Berg, Rance E.

2011-01-01

281

Woofer-tweeter adaptive optics scanning laser ophthalmoscopic imaging based on Lagrange-multiplier damped least-squares algorithm  

PubMed Central

We implemented a Lagrange-multiplier (LM)-based damped least-squares (DLS) control algorithm in a woofer-tweeter dual deformable-mirror (DM) adaptive optics scanning laser ophthalmoscope (AOSLO). The algorithm uses data from a single Shack-Hartmann wavefront sensor to simultaneously correct large-amplitude low-order aberrations by a woofer DM and small-amplitude higher-order aberrations by a tweeter DM. We measured the in vivo performance of high resolution retinal imaging with the dual DM AOSLO. We compared the simultaneous LM-based DLS dual DM controller with both single DM controller, and a successive dual DM controller. We evaluated performance using both wavefront (RMS) and image quality metrics including brightness and power spectrum. The simultaneous LM-based dual DM AO can consistently provide near diffraction-limited in vivo routine imaging of human retina. PMID:21750774

Zou, Weiyao; Qi, Xiaofeng; Burns, Stephen A.

2011-01-01

282

Analysis of complex elastic structures by a Rayleigh-Ritz component modes method using Lagrange multipliers. Ph.D. Thesis  

NASA Technical Reports Server (NTRS)

The free vibrations of elastic structures of arbitrary complexity were analyzed in terms of their component modes. The method was based upon the use of the normal unconstrained modes of the components in a Rayleigh-Ritz analysis. The continuity conditions were enforced by means of Lagrange Multipliers. Examples of the structures considered are: (1) beams with nonuniform properties; (2) airplane structures with high or low aspect ratio lifting surface components; (3) the oblique wing airplane; and (4) plate structures. The method was also applied to the analysis of modal damping of linear elastic structures. Convergence of the method versus the number of modes per component and/or the number of components is discussed and compared to more conventional approaches, ad-hoc methods, and experimental results.

Klein, L. R.

1974-01-01

283

Science Enabled by the Ares V: A Large Monolithic Telescope Placed at the Second Sun-Earth Lagrange Point  

NASA Technical Reports Server (NTRS)

The payload mass and volume capabilities of the planned Ares V launch vehicle provide the science community with unprecedented opportunities to place large science payloads into low earth orbit and beyond. One example, the outcome of a recent study conducted at the NASA Marshall Space Flight Center, is a large, monolithic telescope with a primary mirror diameter of 6.2 meters placed into a halo orbit about the second Sun-Earth Lagrange point, or L2, approximately 1.5 million kin beyond Earth's orbit. Operating in the visible and ultraviolet regions of the electromagnetic spectrum, such a large telescope would allow astronomers to detect bio-signatures and characterize the atmospheres of transiting exoplanets, provide high resolution imaging three or more times better than the Hubble Space Telescope and the James Webb Space Telescope, and observe the ultraviolet light from warm baryonic matter.

Hopkins, Randall C.; Stahl, H. Philip

2007-01-01

284

IL-22 in tissue-protective therapy  

PubMed Central

IL-22, a member of the IL-10 cytokine family, has recently gained significant attention as a protective agent in murine models of diseases driven by epithelial injury. Like its biochemical and functional sibling IL-10, IL-22 elicits cellular activation primarily by engaging the STAT3 signalling pathway. Exclusively produced by leukocytes, but targeting mostly cells of epithelial origin, IL-22 has been proposed as a specialized cytokine messenger acting between leukocytic and non-leukocytic cell compartments. A lack of response in leukocytes to IL-22 mirrors tightly controlled IL-22 receptor expression and probably explains the apparent lack of instant adverse effects after systemic IL-22 administration to mice. Anti-apoptotic, pro-proliferative and pro-regenerative characteristics the major biological properties of this cytokine. Specifically, application of IL-22 is associated with tissue protection and/or regeneration in murine models of infection/microbe-driven inflammation at host/environment interfaces, ventilator-induced lung injury, pancreatitis and liver damage. Overall, preclinical studies would support therapeutic administration of seemingly well-tolerated recombinant IL-22 for treatment of an array of acute diseases manifested in epithelial tissues. However, the feasibility of prolonged administration of this cytokine is expected to be restricted by the tumourigenic potential of the IL-22/STAT3 axis. IL-22, moreover, apparently displays an inherent context-specific capacity to amplify distinct aspects of autoimmune inflammation. Here, the prospects, expectations and restrictions of IL-22 administration in tissue-protective therapy are discussed. PMID:23530726

Muhl, Heiko; Scheiermann, Patrick; Bachmann, Malte; Hardle, Lorena; Heinrichs, Anika; Pfeilschifter, Josef

2013-01-01

285

Tour of Park Geology: Plate Tectonics  

NSDL National Science Digital Library

This National Park Service (NPS) site provides links to geology field notes providing information about National Parks, National Monuments, and National Recreation Areas that have to do with plate tectonics. The site also has illustrations and descriptions of different plate boundaries. The parks are divided into categories depending on which type of plate boundary they are located on. This includes divergent boundaries(active and ancient), convergent boundaries (ocean-ocean, continent-continent, continent-ocean), transform faults, hot spots, and accreted terrains. Parks referenced include Virgin Islands National Park, Florissant Fossil Beds National Monument, Hawaii Volcanoes National Park, and many more.

286

Mesa Verde National Park: Educational Resources  

NSDL National Science Digital Library

This National Park Service site contains general information on planning a visit to the park; information on plants, animals, geology, cliff dwellings, surface archaeological sites, and history of the park; and a classroom activities section. School group activities at the park include identifying geologic formations, seeing museum videos and dioramas, going on trails and tours, and attending evening campground programs. Classroom activities involve the use of a park map, the development of ancestral Puebloan society from about AD 1 to AD 1300, and the history of the National Park Service.

287

Geology Fieldnotes: Badlands National Park, South Dakota  

NSDL National Science Digital Library

Badlands National Park, located in southwestern South Dakota, consists of 244,000 acres of sharply eroded buttes, pinnacles and spires blended with the largest, protected mixed grass prairie in the United States. Features include information on park geology, maps, photographs, visitor information, links to related publications, and lesson plans for teaching geology with National Park examples. The park geology section discusses the Park's geologic history during the Eocene and Oligocene epochs and the rich fossil deposits found there. Maps of the park and the surrounding area are included.

288

Hmgb1-IL-23-IL-17-IL-6-Stat3 Axis Promotes Tumor Growth in Murine Models of Melanoma  

PubMed Central

In order to understand how tumor cells can escape immune surveillance mechanisms and thus develop antitumor therapies, it is critically important to investigate the mechanisms by which the immune system interacts with the tumor microenvironment. In our current study, IL-17 deficiency results in reduced melanoma tumor size, diminished numbers of proliferating cells and blood vessels, and decreased percentage of CD11b+Gr-1+ MDSCs in tumor tissues. IL-17 promotes IL-6 induction and Stat3 activation. Treatment of Stat3 inhibitor WP1066 in B16-F10 tumor cells inoculated wild-type mice inhibits tumor growth. Additional administration of recombinant IL-6 into B16-F10 tumor-bearing IL-17?/? mice results in markedly increased tumor size and p-Stat3 expression, whereas additional recombinant IL-17 administration into B16-F10 tumor-bearing wild-type mice treated with anti-IL-6 mAb does not significantly alter the tumor growth and p-Stat3 expression. In our further study, blockade of Hmgb1-RAGE pathway inhibits melanoma tumor growth and reduces production of IL-23 and IL-17. All these data suggest that Hmgb1-IL-23-IL-17-IL-6-Stat3 axis plays a pivotal role in tumor development in murine models of melanoma, and blocking any portion of this axis will attenuate melanoma tumor growth. PMID:24453427

Tang, Qiu; Li, Jian; Li, Pan; Zou, Zhenwei; Xiao, Yin

2013-01-01

289

Hmgb1-IL-23-IL-17-IL-6-Stat3 axis promotes tumor growth in murine models of melanoma.  

PubMed

In order to understand how tumor cells can escape immune surveillance mechanisms and thus develop antitumor therapies, it is critically important to investigate the mechanisms by which the immune system interacts with the tumor microenvironment. In our current study, IL-17 deficiency results in reduced melanoma tumor size, diminished numbers of proliferating cells and blood vessels, and decreased percentage of CD11b(+)Gr-1(+) MDSCs in tumor tissues. IL-17 promotes IL-6 induction and Stat3 activation. Treatment of Stat3 inhibitor WP1066 in B16-F10 tumor cells inoculated wild-type mice inhibits tumor growth. Additional administration of recombinant IL-6 into B16-F10 tumor-bearing IL-17(-/-) mice results in markedly increased tumor size and p-Stat3 expression, whereas additional recombinant IL-17 administration into B16-F10 tumor-bearing wild-type mice treated with anti-IL-6 mAb does not significantly alter the tumor growth and p-Stat3 expression. In our further study, blockade of Hmgb1-RAGE pathway inhibits melanoma tumor growth and reduces production of IL-23 and IL-17. All these data suggest that Hmgb1-IL-23-IL-17-IL-6-Stat3 axis plays a pivotal role in tumor development in murine models of melanoma, and blocking any portion of this axis will attenuate melanoma tumor growth. PMID:24453427

Tang, Qiu; Li, Jian; Zhu, Hongfei; Li, Pan; Zou, Zhenwei; Xiao, Yin

2013-01-01

290

Serum IL-1?, IL-6, IL-8, and TNF-? Levels in Early Diagnosis and Management of Neonatal Sepsis  

PubMed Central

Aim. To determine serum IL-1?, IL-6, IL-8, and TNF-? levels in neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow up. Methods. This prospective study was performed on newborns who were hospitalized for neonatal sepsis and who were classified as culture-proven sepsis (n=12), as culture-negative sepsis (n=21), and as healthy newborns (n=17). Results. At the time of diagnosis, serum IL-1?, IL-6, IL-8, and TNF-? levels of culture-proven sepsis were significantly higher than those of the control groups (P<.05). At the time of diagnosis, IL-1?, IL-6, IL-8, and TNF-? levels of culture-proven sepsis and culture-negative sepsis were significantly higher than levels at the seventh day after antibiotic treatment. Conclusion. Serum IL-1?, IL-6, IL-8, and TNF-? are mediators of inflammation and can be used at the diagnosis and at the evaluation of the therapeutic efficiency in neonatal sepsis. PMID:18274637

Kurt, A. Nese Citak; Aygun, A. Denizmen; Godekmerdan, Ahmet; Kurt, Abdullah; Dogan, Yasar; Yilmaz, Erdal

2007-01-01

291

Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4.  

PubMed

The production of IL-12 by macrophages/dendritic cells (Mphi/DC) is mediated either by a T cell-dependent pathway that is induced primarily by the interaction of CD40 ligand (CD40L) on activated T cells with CD40 on IL-12-producing cells or by a T cell-independent pathway that is induced by bacteria or bacterial products and enhanced by interferon-gamma (IFN-gamma). In this study we investigated the ability of the Th2-type cytokines interleukin (IL)-10, IL-6, and IL-4 to modulate IL-12 production in Mphi/DC induced through the two pathways. IL-12 production was induced in Mphi/DC from normal mice by stimulation with the combination of IFN-gamma plus lipopolysaccharide (LPS) or Staphylococcus aureus Cowan I (a model for the T cell-independent pathway) or by co-culture with Chinese hamster ovary (CHO) cells transfected with the CD40L (a model for the T cell-dependent pathway). The effects of three Th2-type cytokines on IL-12 production by Mphi/DC through the two pathways were examined. IL-10 inhibited IL-12 production induced through both pathways, although the inhibitory effect was more potent on the (IFN-gamma + LPS)-induced pathway. IL-6 inhibited only (LPS + IFN-gamma)-induced IL-12 production. The effect of IL-4 was particularly noteworthy: this cytokine inhibited (LPS + IFN-gamma)-induced IL-12 production, whereas it potentiated the production of IL-12 induced by CD40L. Regulation of IL-12 protein production by IL-10 and IL-4 was found to correspond to the levels of mRNA accumulation for the p40 and p35 IL-12 genes, whereas the presence of IL-6 during stimulation decreased IL-12 protein production without affecting steady-state mRNA levels. These results indicate that IL-12 production in Mphi/DC induced through a T cell-dependent or -independent pathway is positively or negatively regulated by particular cytokines at various control levels. PMID:9000540

Takenaka, H; Maruo, S; Yamamoto, N; Wysocka, M; Ono, S; Kobayashi, M; Yagita, H; Okumura, K; Hamaoka, T; Trinchieri, G; Fujiwara, H

1997-01-01

292

Bibliography of Doctor Chul Park  

NASA Technical Reports Server (NTRS)

This document contains a comprehensive bibliography of the published works, and a short biography, of Dr. Chul Park. The contents of this bibliography were compiled primarily from the NASA RECON data base. The RECON citations have been modified to appear in a uniform format with all other listed citations . These other citations were located by computer searches in the INSPEC, NTIS, COMPENDEX, and Chemical Abstracts data bases, as well as through the cooperation of Dr. Chul Park, and his associates in the Reacting Flow Environments Branch at NASA Ames Research Center. All citations are presented in an approximate reverse chronological order from the present date. This work was created to honor the occasion of Dr. Chul Park's retirement on December 14, 1994, after 27 years of distinguished government service at the NASA Ames Research Center.

Gochberg, Lawrence A.; Venkatapathy, Ethiraj; Park, Chul

1995-01-01

293

Amusement park injuries and deaths.  

PubMed

Media coverage of amusement park injuries has increased over the past several years, raising concern that amusement rides may be dangerous. Amusement park fatalities and increases in reported injuries have prompted proposed legislation to regulate the industry. Since 1979, the medical literature has published reports of 4 subdural hematomas, 4 internal carotid artery dissections, 2 vertebral artery dissections, 2 subarachnoid hemorrhages, 1 intraparenchymal hemorrhage, and 1 carotid artery thrombosis with stroke, all related to roller coaster rides. In this article, we review reports of amusement park injuries in the medical literature and Consumer Product Safety Commission data on the overall risk of injury. We also discuss the physics and the physiologic effects of roller coasters that may influence the type and severity of injuries. Although the risk of injury is low, emergency physicians are advised to include participation on thrill rides as part of their history, particularly when evaluating patients presenting with neurologic symptoms. PMID:11782733

Braksiek, Robert J; Roberts, David J

2002-01-01

294

Lichens of the U. S. national parks  

USGS Publications Warehouse

Over 26,100 records of lichens present in 144 U.S. national park units were assembled from various sources into a database and analyzed. Within these 144 park units 2,435 species and 375 genera are reported, representing 63% and 74% of the North American flora, respectively. The park units are located in 41 states and Washington, D.C. The average number of species in a park is 104, but the median is 60, indicating there are many parks with a small number of species and a few with high numbers. Isle Royale National Park has the most species, 611, and twelve parks have only one species reported. The number of records of lichens present ranged from one for 25 parks, to 1,623 for Isle Royale. Physcia aipolia is the most frequently observed species, being found in 65 parks. One fourth of the park units are classified cultural resource parks, while the remainder are considered natural resource parks. This study was based on 453 sources, including literature citations, park reports and collections in the University of Minnesota Herbarium. Copyright ?? 2005 by the American Bryological and Lichenological Society, Inc.

Bennett, J. P.; Wetmore, C. M.

2005-01-01

295

IL26 gene inactivation in Equidae.  

PubMed

Interleukin-26 (IL26) is a member of the IL10 cytokine family. The IL26 gene is located between two other well-known cytokines genes of this family encoding interferon-gamma (IFNG) and IL22 in an evolutionary conserved gene cluster. In contrast to humans and most other mammals, mice lack a functional Il26 gene. We analyzed the genome sequences of other vertebrates for the presence or absence of functional IL26 orthologs and found that the IL26 gene has also become inactivated in several equid species. We detected a one-base pair frameshift deletion in exon 2 of the IL26 gene in the domestic horse (Equus caballus), Przewalski horse (Equus przewalskii) and donkey (Equus asinus). The remnant IL26 gene in the horse is still transcribed and gives rise to at least five alternative transcripts. None of these transcripts share a conserved open reading frame with the human IL26 gene. A comparative analysis across diverse vertebrates revealed that the IL26 gene has also independently been inactivated in a few other mammals, including the African elephant and the European hedgehog. The IL26 gene thus appears to be highly variable, and the conserved open reading frame has been lost several times during mammalian evolution. PMID:23808390

Shakhsi-Niaei, M; Drögemüller, M; Jagannathan, V; Gerber, V; Leeb, T

2013-12-01

296

36 CFR 7.66 - North Cascades National Park.  

Code of Federal Regulations, 2013 CFR

...SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.66 North Cascades...between the park boundary and the Cascade Pass Trailhead parking area. (2) The Stehekin Valley Road between the park...

2013-07-01

297

36 CFR 7.66 - North Cascades National Park.  

Code of Federal Regulations, 2010 CFR

...SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.66 North Cascades...between the park boundary and the Cascade Pass Trailhead parking area. (2) The Stehekin Valley Road between the park...

2010-07-01

298

36 CFR 7.66 - North Cascades National Park.  

Code of Federal Regulations, 2012 CFR

...SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.66 North Cascades...between the park boundary and the Cascade Pass Trailhead parking area. (2) The Stehekin Valley Road between the park...

2012-07-01

299

36 CFR 7.66 - North Cascades National Park.  

Code of Federal Regulations, 2011 CFR

...SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.66 North Cascades...between the park boundary and the Cascade Pass Trailhead parking area. (2) The Stehekin Valley Road between the park...

2011-07-01

300

Division of Administration and Finance Parking and Transportation Services  

E-print Network

asphalt maintenance. Areas of these lots will be unavailable for parking during the repairsDivision of Administration and Finance Parking and Transportation Services Press Release AND PARKING LOT MAINTENANCE SCHEDULED Houston, June 25, 2013 ­ Parking and Transportation Services

Glasser, Adrian

301

36 CFR 7.44 - Canyonlands National Park.  

Code of Federal Regulations, 2013 CFR

...2013-07-01 2013-07-01 false Canyonlands National Park. 7.44 Section 7.44 Parks...INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.44 Canyonlands National Park. (a) Motorized Vehicle...

2013-07-01

302

36 CFR 7.44 - Canyonlands National Park.  

Code of Federal Regulations, 2012 CFR

...2012-07-01 2012-07-01 false Canyonlands National Park. 7.44 Section 7.44 Parks...INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.44 Canyonlands National Park. (a) Motorized Vehicle...

2012-07-01

303

36 CFR 7.44 - Canyonlands National Park.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 2010-07-01 false Canyonlands National Park. 7.44 Section 7.44 Parks...INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.44 Canyonlands National Park. (a) Motorized Vehicle...

2010-07-01

304

36 CFR 7.44 - Canyonlands National Park.  

Code of Federal Regulations, 2011 CFR

...2011-07-01 2011-07-01 false Canyonlands National Park. 7.44 Section 7.44 Parks...INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.44 Canyonlands National Park. (a) Motorized Vehicle...

2011-07-01

305

2012-13 UT Basketball Parking Information Campus Parking: On weekdays, the majority of parking on campus requires a basketball  

E-print Network

DURING WEEKDAY BASKETBALL GAMES: The following parking areas will be designated for students with a valid *FACULTY & STAFF WORKING DURING WEEKDAY BASKETBALL GAMES: The following parking areas will be designated for faculty and staff with a valid parking permit who are working during basketball games: LOCATION AREA

Tennessee, University of

306

Everglades National Park Including Biscayne National Park. Activity Book.  

ERIC Educational Resources Information Center

Intended to help elementary school children learn about the resources of the Everglades and Biscayne National Parks, this activity book includes information, puzzles, games, and quizzes. The booklet deals with concepts related to: (1) the seasons; (2) fire ecology; (3) water; (4) fish; (5) mammals; (6) mosquitos; (7) birds; (8) venomous snakes;…

Ruehrwein, Dick

307

The Access Almanac: Solar Parking Requirements  

E-print Network

charging electric cars. If the solar energy is being storedcars can feel green when they park in the shade of solarSolar canopies over parking lots can provide some of the electricity needed for these cars

Shoup, Donald

2012-01-01

308

IL-6 promotes NK cell production of IL-17 during toxoplasmosis1  

PubMed Central

Previous studies have implicated T cell production of IL-17 in resistance to T. gondii as well as the development of immune mediated pathology during this infection. Analysis of C57BL/6 and C57BL/6 RAG-/- mice challenged with T. gondii identified NK cells as a major innate source of IL-17. The ability of soluble toxoplasma antigen to stimulate NK cells to produce IL-17 was dependent on the presence of accessory cells and the production of IL-6, IL-23 and TGF-?. In contrast, these events were inhibited by IL-2, IL-15 and IL-27. Given that IL-6 was one of the most potent enhancers of NK cell production of IL-17, further studies revealed that only a subset of NK cells expressed both chains of the IL-6R, IL-6 upregulated expression of the Th17 associated transcription factor ROR?t, and IL-6-/- mice challenged with T. gondii had a major defect in NK cell production of IL-17. Together, these data indicate that many of the same cytokines that regulate Th17 cells are part of a conserved pathway that also control innate production of IL-17 and identify a major role for IL-6 in the regulation of NK cell responses. PMID:20083665

Passos, Sara T.; Silver, Jonathan S.; O'Hara, Aisling C.; Sehy, David; Stumhofer, Jason S.; Hunter, Christopher A.

2013-01-01

309

Smart Parking Management Field Test: A Bay Area Rapid Transit (BART) District Parking Demonstration  

Microsoft Academic Search

In almost every major city in the U.S. and internationally, parking problems are ubiquitous. It is well known that the limited availability of parking contributes to roadway congestion, air pollution, and driver frustration and that the cost of expanding traditional parking capacity is frequently prohibitive. However, less research has addressed the effect of insufficient parking at transit stations on transit

Susan Shaheen

2005-01-01

310

Smart Parking Management Pilot Project: A Bay Area Rapid Transit (BART) District Parking Demonstration  

Microsoft Academic Search

This report presents early findings from an application of advanced parking technologies to maximize existing parking capacity at the Rockridge BART station, which was launched in December 2004 in the East San Francisco Bay Area. The smart parking system includes traffic sensors that count the number of vehicles entering and exiting the parking lots at the station. A reservation system

Susan Shaheen; Caroline J. Rodier; Amanda M. Eaken

2005-01-01

311

Application for Special Use Parking Permit Parking and Transportation Services EMPLOYEES ONLY  

E-print Network

of a personal vehicle to conduct University business and the specific parking areas the employee or departmentApplication for Special Use Parking Permit Parking and Transportation Services EMPLOYEES ONLY (657 or their designees will review and confirm special use parking permits annually or more frequently if necessary

de Lijser, Peter

312

Yosemite National Park National Park Service U.S. Department of the Interior  

E-print Network

What are lichens? Yosemite National Park National Park Service U.S. Department of the Interior interested in lichens? What is currently being done to study lichens in the park? There has never been biodiversity of lichens and other bryophytes. The National Park Service is partnering with the climbing

LeTourneau, Peter M.

313

Nature and Science at Canyonlands National Park  

NSDL National Science Digital Library

This National Park Service (NPS) website highlights the environment and ecosystems found in Canyonlands National Park. Topics include animals in the park (amphibians, reptiles, birds, fish and mammals), plant life (cacti, grasses, lichens, mosses, liverworts, trees, shrubs and wildflowers), environmental factors (air quality, invasive species, endangered fish, noise pollution, peregrine falcons and bighorn sheep), and natural features (deserts, pools, rivers and stream, geology). Links are provided to downloadable brochures and reports on park research activities and additional information on wildlife and plants.

314

Biological significance of soluble IL-2 receptor  

PubMed Central

A NUMBER of receptors for growth factors and differentiation antigens have been found to be secreted or released by cells. Following mononuclear cell (MNC) activation and interleukin-2 receptor (IL-2R) expression, a soluble form of the Alpha;-chain of IL-2R (sIL-2R) is released. The sIL-2R has been shown to be present in the culture supernatants of activated MNCs as well as in normal sera and, in higher amounts, in sera from subjects affected by several diseases including neoplastic, infectious and autoimmune ones, and in sera from transplanted patients suffering allograft rejection. The blood sIL-2R levels depend on the number of producing cells and the number of molecules per cell, so that sIL-2R blood values may represent an index of the number and the functional state of producing cells, both normal and neoplastic. Thus, monitoring of the immune system, mostly T-cells and haematological malignancies might be targets for the measurement of sIL-2R. Since many conditions may influence sIL-2R production, little diagnostic use may result from these measurements. However, since blood sIL-2R levels may correlate with disease progression and/or response to therapy, their measurement may be a useful index of activity and extent of disease. The precise biological role of the soluble form of the IL-2R is still a matter of debate. However, we know that increased sIL-2R levels may be observed in association with several immunological abnormalities and that sIL-2R is able to bind IL-2. It is conceivable then that in these conditions the excess sIL-2R released in vivo by activated lymphoid cells or by neoplastic cells may somehow regulate IL-2-dependent processes. On the other hand, it cannot exclude that sIL-2R is a by-product without biological significance. Finally, it is puzzling that in many conditions in which an increase of blood sIL-2R values has been observed, MNCs display a decreased in vitro capacity to produce sIL-2R. These seemingly contrasting findings are discussed in the light of the data showing that sIL-2R production correlates with IL-2 production. PMID:18475497

Candore, Giuseppina; Cigna, Diego; Colucci, Antonio Tobia; Modica, Maria Assunta

1993-01-01

315

NORTH PARK PHACELIA Conservation Action Plan  

E-print Network

NORTH PARK PHACELIA Conservation Action Plan 2011 Update North Park phacelia © Frank Weston Plant Panjabi, S. and B. Neely. 2011. North Park Phacelia Conservation Action Plan 2011 Update. Prepared Conservation Action Plan was developed in 2008 (Kram et al. 2008; available on-line at http

316

Traffic and Parking Services Financial Statements  

E-print Network

Traffic and Parking Services Financial Statements June 30, 2011 #12;FLORIDA ATLANTIC UNIVERSITY PARKING AND TRANSPORTATION SERVICES MANAGEMENT DISCUSSION AND ANALYSIS JUNE 30, 2011 Our discussion revenue increased 6%. Traffic fines and parking fees and meters also contributed to the increase

Fernandez, Eduardo

317

Traffic and Parking Services Financial Statements  

E-print Network

Traffic and Parking Services Financial Statements June 30, 2012 #12;FLORIDA ATLANTIC UNIVERSITY PARKING AND TRANSPORTATION SERVICES MANAGEMENT DISCUSSION AND ANALYSIS JUNE 30, 2012 Our discussion revenue increased 20%. Traffic fines and parking fees and meters also contributed to the increase

Fernandez, Eduardo

318

Camosun College Transportation and Parking Management Plan  

Microsoft Academic Search

Summary The Camosun College Transportation and Parking Management (TPM) Project is a planning process to identify optimal solutions to campus transportation and parking problems. The TPM project identifies specific ways to improve transportation and parking management in order to create a more sustainable campus. The plan will be flexible and responsive to future demands and conditions. This TPM report describes

Todd Litman

319

Geology Fieldnotes: Isle Royale National Park, Michigan  

NSDL National Science Digital Library

This National Park Service (NPS) website examines the geology of Isle Royale National Park in Michigan. It looks at the geologic history of this archipelago, beginning 1.2 billion years ago and progressing through volcanics, rock formations and copper deposits, to the Ice Age. There are links to park maps, visitor information, and additional resources.

320

"The Rosa Parks Story": Guide for Educators.  

ERIC Educational Resources Information Center

On December 1, 1955, Rosa Parks, a black seamstress, refused to give up her seat to a white man on a public bus in Montgomery, Alabama, and she was arrested. On that day, Rosa Parks became the mother of the modern civil rights movement. This study guide may be used as a companion to "The Rosa Parks Story" video which aired on CBS television…

Onish, Liane B.

321

Geology Fieldnotes: Kenai Fjords National Park, Alaska  

NSDL National Science Digital Library

This National Park Service (NPS) website examines the geology of Kenai Fjords National Park in Alaska. It highlights the glacier-carved valleys, 1964 Alaskan earthquake, nunataks (peaks), and wildlife of the park. There are links to visitor information, maps, and additional resources.

322

45 CFR 3.23 - Parking.  

Code of Federal Regulations, 2011 CFR

...a lane, space, or area not designated by a sign for parking, and/or standing...visitor must park in an area identified for that purpose...such as “visitor parking” and “reserved for visitors...any other unpaved, area without the...

2011-10-01

323

SECTION ELEVEN Site Design Guidelines Parking  

E-print Network

.1 GUIDELINES A parking lot shall be defined as a paved area exis ng primarily for motor vehicle of the facility. Where very large parking areas are required, the lots shall: · Be designed as a series of smaller areas providing parking spaces. · Separated by areas planted in trees and grass. · Provide

Duchowski, Andrew T.

324

45 CFR 3.23 - Parking.  

Code of Federal Regulations, 2012 CFR

...a lane, space, or area not designated by a sign for parking, and/or standing...visitor must park in an area identified for that purpose...such as “visitor parking” and “reserved for visitors...any other unpaved, area without the...

2012-10-01

325

45 CFR 3.23 - Parking.  

Code of Federal Regulations, 2010 CFR

...a lane, space, or area not designated by a sign for parking, and/or standing...visitor must park in an area identified for that purpose...such as “visitor parking” and “reserved for visitors...any other unpaved, area without the...

2010-10-01

326

MILLERSVILLE UNIVERSITY PARKING REGULATIONS AND PROCEDURES  

E-print Network

and sanctions. 1.6 Physical parking facilities and areas are provided through the University Office of FinanceMILLERSVILLE UNIVERSITY PARKING REGULATIONS AND PROCEDURES 2012-2013 CONTENTS 1. General. Parking Permits 5.2 Commuting Student Permits 5.3 Evening Permits 5.4 Resident Student Permits 5

Hardy, Christopher R.

327

45 CFR 3.23 - Parking.  

Code of Federal Regulations, 2013 CFR

...a lane, space, or area not designated by a sign for parking, and/or standing...visitor must park in an area identified for that purpose...such as “visitor parking” and “reserved for visitors...any other unpaved, area without the...

2013-10-01

328

Where Innovation Is Tradition Parking & Transportation  

E-print Network

& Transportation Advisory Committee · Faculty,staff, & student reps #12;Where Innovation Is Tradition Parking expenses with parking revenue and some student fee(about $88/student) · Overall budget nearly $15,000,000 annually #12;Where Innovation Is Tradition Parking & Transportation Budget · Expenses · Debt service-$6

329

Geology Fieldnotes: Acadia National Park, Maine  

NSDL National Science Digital Library

This National Park Service website highlights the geology of Acadia National Park. The story begins 500 million years ago, and goes through rock cycles, formations (Ellsworth, Bar Harbor, and Cranberry formations), intrusions, the Ice Age, glacial features, and development of shore patterns. There are area and park maps, photos, and links to additional information.

330

78 FR 24323 - National Park Week, 2013  

Federal Register 2010, 2011, 2012, 2013

...Proclamation 8961 of April 19, 2013 National Park Week, 2013 By the President of the United States...to be passed on. During National Park Week, we celebrate the wonders entrusted to...summon us to experience it firsthand. This week, the National Park Service will make...

2013-04-24

331

Queen's Parking Regulations for Motor Vehicles Message from the Manager  

E-print Network

Definitions Section 2 Jurisdiction Section 3 Parking Permit Information Section 4 - Parking Areas and Parking muscular, including motorcycles. NO PARKING AREA All University property, including roadways, grounds, and paved areas are No Parking Areas, unless signed to the contrary. PARKED Any motor vehicle, which

Graham, Nick

332

Parking for IMA patrons on Special Events Evenings: Women's Basketball  

E-print Network

in front of the IMA starting 3 hours prior to Tip-Off. The area will be reserved for Event Parking. Parking or in E12 (in designated areas). $8 Parking $8 Disability TYEE Parking ONLY E1 $8 TYEEONLY Padelford $8Parking for IMA patrons on Special Events Evenings: Women's Basketball There will be No parking

Washington at Seattle, University of

333

Designing Interactive Theme Park Rides  

Microsoft Academic Search

Pirates of the Caribbean-Battle for the Buccaneer Gold is an interactive theme park ride based on the classic Pirates of the Caribbean attraction at Disneyland. With themes and inspiration taken from the ride, this virtual interactive experience treats four guests to an overwhelming immersive adventure on the high seas. One guest steers at a real helm while the other three

Jesse Schell; Joe Shochet

2001-01-01

334

Young Eun Park Vanderbilt University  

E-print Network

in the Stroop Task: The effect of abrupt onsets. #12;2 CONFERENCE PRESENTATIONS Park, Y. E., Jung, H., & Cho, Y. (2009). Attentional capture by the color word in the Stroop task: The effect of abrupt onsets. S. (2011). Contents of the Attentional Set Revealed by the Negative Spatial Cueing Effect. 52nd

Tong, Frank

335

Egmont National Park, New Zealand  

NASA Technical Reports Server (NTRS)

The lush forests of Egmont National Park, on New Zealand's North Island, contrast with the pasturelands outside the circular park boundaries. The unique shape of the park results from its first protection in 1881, which specified that a forest reserve would extend in a 9.6 km radius from the summit of Mt. Taranaki (named Mt. Egmont by Captain Cook). The park covers about 33,500 hectares and Mt. Egmont stands at 2518 m. The volcano began forming 70,000 years ago, and last erupted in 1755. A series of montane habitats occur in procession up the flanks of the volcano-from rainforest, to shrubs, to alpine, and finally snow cover. Image STS110-726-6, was taken by Space Shuttle crewmembers on 9 April 2002 using a Hasselblad film camera. Image provided by the Earth Sciences and Image Analysis Laboratory at Johnson Space Center. Additional images taken by astronauts and cosmonauts can be viewed at the NASA-JSC Gateway to Astronaut Photography of Earth.

2002-01-01

336

JOHNSON PARK RUTGERS GOLF COURSE  

E-print Network

JOHNSON PARK RUTGERS GOLF COURSE MITCHELL AVE TOOLANST HOES LN MARIONCT HOES LN W GATES AVE RIVER RD TITSWORTHPL TAYLORRD BO W SERRD BEVIE R RD BRETT RD DAVIDSON RD LANDINGLN 18 18 ToRt287 54 64 51 P McCormick Hall Richardson Apartments Russell Apartments Johnson Apartments Waksman Greenhouse Civil

Hanson, Stephen José

337

Hospital Specialty Clinics Park Center  

E-print Network

Center Mental Health Complex Curative Blood Center Research Institute Research Park Center Fitness Center Entrance to Medical College of Wisconsin Eye Institute Sargeant Health Center Pavilion Children's Hospital* 18* 13 19* 1. Medical College of Wisconsin (MCW) A. Health Research Center B. MCW Medical Education

338

DIPLOSTOMOSIS IN NORTH PARK, COLORADO  

Microsoft Academic Search

The life cycle of Diplostoinuni spathaceuni (Rudobfi 1819), as it exists in North Park, Colorado, is elucidated. California gulls (Larus californicus), common mergansers (Mergus merganser) and Forster's terns (Sterna forsteri) act as definitive hosts. Two species of water snails, Phvsa gvrina and Lvnzneae elodes, act as first intermediate hosts with seven species of fish as second intermediate hosts: brassy minnows

ROBERT B. DAVIES; WALTER T. BURKHARDE; CHARLES P. HIBLER

1973-01-01

339

How to Park: Teen Drivers  

E-print Network

--those "love taps" can cost $400 or more to fix!). Still not sure how parking affects you? Males ages 15 WHiTE ­ Stop only long enough to pick up or drop off passengers. yEllOW ­ Stop only long enough

Das, Suman

340

Rosa Parks: The Movement Organizes.  

ERIC Educational Resources Information Center

This biography for younger readers describes the life of Rosa Parks, the Alabama black woman whose refusal to give up her seat on a segregated bus helped establish the civil rights movement. The book is introduced by an overview of the movement by Andrew Young and a timeline indicating major historical events from 1954 through 1968. Highlights in…

Friese, Kai

341

Fishes of the Adirondack Park  

Microsoft Academic Search

This review of the ichthyology of the area of the Adirondack Park contained within the blue line centers on biological surveys of the six major watersheds of the study area done in 1930-1935. The total area of 9261 square miles contains 2000-3000 water bodies. The ichthyofauna consists of 96 forms, including four kinds of hybrids commonly produced and used in

1980-01-01

342

UV - RESEARCH TRIANGLE PARK NC  

EPA Science Inventory

Brewer 087 is located in Research Triangle Park NC, measuring ultraviolet solar radiation. Irradiance and column ozone are derived from this data. Ultraviolet solar radiation is measured with a Brewer Mark IV, single-monochrometer, spectrophotometer manufactured by SCI-TEC Instru...

343

IL18: A TH1 -inducing, proinflammatory cytokine and new member of the IL1 family  

Microsoft Academic Search

Formerly called IFN-?–inducing factor, IL-18 is the new name of a novel cytokine that plays an important role in the TH1 response, primarily by its ability to induce IFN-? production in T cells and natural killer cells. Mice deficient in IL-18 have suppressed IFN-? production despite the presence of IL-12. IL-18 is related to the IL-1 family in terms of

Charles A. Dinarello

1999-01-01

344

Astrocytes as antigen-presenting cells: expression of IL-12/IL-23.  

PubMed

Interleukin-12 (IL-12, p70) a heterodimeric cytokine of p40 and p35 subunits, important for Th1-type immune responses, has been attributed a prominent role in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Recently, the related heterodimeric cytokine, IL-23, composed of the same p40 subunit as IL-12 and a unique p19 subunit, was shown to be involved in Th1 responses and EAE. We investigated whether astrocytes and microglia, CNS cells with antigen-presenting cell (APC) function can present antigen to myelin basic protein (MBP)-reactive T cells, and whether this presentation is blocked with antibodies against IL-12/IL-23p40. Interferon (IFN)-gamma-treated APC induced proliferation of MBP-reactive T cells. Anti-IL-12/IL-23p40 antibodies blocked this proliferation. These results support and extend our previous observation that astrocytes and microglia produce IL-12/IL-23p40. Moreover, we show that stimulated astrocytes and microglia produce biologically active IL-12p70. Because IL-12 and IL-23 share p40, we wanted to determine whether astrocytes also express IL-12p35 and IL-23p19, as microglia were already shown to express them. Astrocytes expressed IL-12p35 mRNA constitutively, and IL-23 p19 after stimulation. Thus, astrocytes, under inflammatory conditions, express all subunits of IL-12/IL-23. Their ability to present antigen to encephalitogenic T cells can be blocked by neutralizing anti-IL-12/IL-23p40 antibodies. PMID:16086689

Constantinescu, Cris S; Tani, Marie; Ransohoff, Richard M; Wysocka, Maria; Hilliard, Brendan; Fujioka, Toshiki; Murphy, Sean; Tighe, Patrick J; Das Sarma, Jayasri; Trinchieri, Giorgio; Rostami, Abdolmohamad

2005-10-01

345

A Brief History of IL-9  

PubMed Central

Interleukin-9 was first described in the late 1980s as a member of a growing number of cytokines that had pleiotropic functions in the immune system. Although many biological functions have been attributed to IL-9, it remains an understudied cytokine. A resurgence of interest in IL-9 has been spurred by recent work demonstrating a role for IL-9 in regulating inflammatory immunity, and in defining the transcription factors that activate the Il9 gene in cells that most efficiently produce IL-9. In this review we summarize the characterization of IL-9 biological activities, highlight roles for the cytokine that are clearly defined, and outline questions regarding IL-9 functions that still require further exploration. PMID:21368237

Goswami, Ritobrata; Kaplan, Mark H.

2011-01-01

346

An exploration of the relationship between use of parks and access, park appeal, and communication effectiveness  

E-print Network

AN EXPLORATION OF THE RELATIONSHIP BETWEEN USE OF PARKS AND ACCESS, PARK APPEAL, AND COMMUNICATION EFFECTIVENESS A Dissertation by JAMIE RAE WALKER Submitted to the Office of Graduate Studies of Texas A&M University in partial... fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY December 2008 Major Subject: Recreation, Park and Tourism Sciences AN EXPLORATION OF THE RELATIONSHIP BETWEEN USE OF PARKS AND ACCESS, PARK APPEAL, AND COMMUNICATION...

Walker, Jamie Rae

2009-05-15

347

PARKING TIPS Parking is tight at the beginning of each semester  

E-print Network

. Parking areas that fill up earliest are: · EastDeckII · UnionDeck · Lot18(besideUnionDeck · Lot19,000parkingspacesavailableaway from center-campus, even during peak-use hours. Have a plan in mind for an alternate parking area­ 1 ­ PARKING TIPS Parking is tight at the beginning of each semester Expect parking to be at near

Howitt, Ivan

348

Endogenously expressed IL-13R?2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts.  

PubMed

IL-13 can bind to two distinct receptors: a heterodimer of IL-13R?1/IL-4R? and IL-13R?2. Whereas IL-13R?1/IL-4R? engagement by IL-13 leads to the activation of STAT6, the molecular events triggered by IL-13 binding to IL-13R?2 remain incompletely understood. IL-4 can bind to and signal through the IL-13R?1/IL-4R? complex but does not interact with IL-13R?2. Idiopathic pulmonary fibrosis is a progressive and generally fatal parenchymal lung disease of unknown etiology with no current pharmacologic treatment options that substantially prolong survival. Preclinical models of fibrotic diseases have implicated IL-13 activity on multiple cell types, including macrophages and fibroblasts, in initiating and perpetuating pathological fibrosis. In this study, we show that IL-13, IL-4, IL-13R?2, and IL-13-inducible target genes are expressed at significantly elevated levels in lung tissue from patients with idiopathic pulmonary fibrosis compared with control lung tissue. IL-4 and IL-13 induce virtually identical transcriptional responses in human monocytes, macrophages, and lung fibroblasts. IL-13R?2 expression can be induced in lung fibroblasts by IL-4 or IL-13 via a STAT6-dependent mechanism, or by TNF-? via a STAT6-independent mechanism. Endogenously expressed IL-13R?2 decreases, but does not abolish, sensitivity of lung fibroblasts to IL-13 and does not affect sensitivity to IL-4. Genome-wide transcriptional analyses of lung fibroblasts stimulated with IL-13 in the presence of Abs that selectively block interactions of IL-13 with IL-13R?1/IL-4R? or IL-13R?2 show that endogenously expressed IL-13R?2 does not activate any unique IL-13-mediated gene expression patterns, confirming its role as a decoy receptor for IL-13 signaling. PMID:24879793

Chandriani, Sanjay; DePianto, Daryle J; N'Diaye, Elsa N; Abbas, Alexander R; Jackman, Janet; Bevers, Jack; Ramirez-Carrozzi, Vladimir; Pappu, Rajita; Kauder, Steven E; Toy, Karen; Ha, Connie; Modrusan, Zora; Wu, Lawren C; Collard, Harold R; Wolters, Paul J; Egen, Jackson G; Arron, Joseph R

2014-07-01

349

Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20–IL-20R1–IL-20R2 complex  

PubMed Central

Interleukin-20 (IL-20) is an IL-10-family cytokine that regulates innate and adaptive immunity in skin and other tissues. In addition to protecting the host from various external pathogens, dysregulated IL-20 signaling has been shown to contribute to the pathogenesis of human psoriasis. IL-20 signals through two cell-surface receptor heterodimers, IL-20R1–IL-20R2 and IL-22R1–IL-20R2. In this report, crystals of the IL-20–IL-20R1–IL-20R2 ternary complex have been grown from polyethylene glycol solutions. The crystals belonged to space group P41212 or P43212, with unit-cell parameters a = 111, c = 135?Å, and diffracted X-­rays to 3?Å resolution. The crystallographic asymmetric unit contains one IL-­20–IL-20R1–IL-20R2 complex, corresponding to a solvent content of approximately 54%. PMID:22232181

Logsdon, Naomi J.; Allen, Christopher E.; Rajashankar, Kanagalaghatta R.; Walter, Mark R.

2012-01-01

350

Interleukin-10 (IL-10) Inhibits Borrelia burgdorferi-Induced IL-17 Production and Attenuates IL-17-Mediated Lyme Arthritis  

PubMed Central

Previous studies have shown that cells and cytokines associated with interleukin-17 (IL-17)-driven inflammation are involved in the arthritic response to Borrelia burgdorferi infection. Here, we report that IL-17 is a contributing factor in the development of Lyme arthritis and show that its production and histopathological effects are regulated by interleukin-10 (IL-10). Spleen cells obtained from B. burgdorferi-infected, “arthritis-resistant” wild-type C57BL/6 mice produced low levels of IL-17 following stimulation with the spirochete. In contrast, spleen cells obtained from infected, IL-10-deficient C57BL/6 mice produced a significant amount of IL-17 following stimulation with B. burgdorferi. These mice developed significant arthritis, including erosion of the bones in the ankle joints. We further show that treatment with antibody to IL-17 partially inhibited the significant hind paw swelling and histopathological changes observed in B. burgdorferi-infected, IL-10-deficient mice. Taken together, these findings provide additional evidence of a role for IL-17 in Lyme arthritis and reveal an additional regulatory target of IL-10 following borrelial infection. PMID:24042116

Hansen, Emily S.; Medic, Velinka; Kuo, Joseph; Warner, Thomas F.; Schell, Ronald F.

2013-01-01

351

IL-33 mediates the expressions of IL-5 and IL-13 in Angiostrongylus cantonensis-infected mice.  

PubMed

Angiostrongylus cantonensis is the major cause of human eosinophilic meningoencephalitis. C57BL/6 mice were experimentally infected with 35 infectious larvae. Two groups of infected mice received intraperitoneal injections of mouse IL-33 (1?g) or anti-IL-33 monoclonal antibody (mAb) (10?g) 3days post infection (dpi) and subsequent booster shots of the same dose at 5day intervals. Blood samples from each group were collected weekly for assays. IgE levels were significantly increased in all infected mice. The eosinophil percentage and levels of IL-5 and IL-13 significantly increased in the IL-33-treated group relative to infected but non-treated animals. The level of IL-5 decreased in the mAb-treated group. The severity of eosinophilic meningitis was exacerbated in the IL-33 injected group. Taken together, these results suggest that IL-33 mediates the expressions of IL-5 and IL-13, and plays a crucial role in the pathogenesis of angiostrongylosis. PMID:24076431

Du, Wen-Yuan; Chen, Chi-Wu; Lin, Feng-Kuan; Chuang, Chih-Cheng

2013-11-01

352

Alternative Transportation and Travel Information Technologies: Monitoring Parking Lot Conditions Over Three Summer Seasons at Acadia National Park  

Microsoft Academic Search

Executive Summary: Parking lots are an important transportation re- source of Acadia National Park, as they provide visitors convenient access to some of the most desirable destinations within the park. However, during the summer, parking at some of the most popular destinations is in short supply. Drivers often park vehicles outside designated parking spaces within the lots and along the

John J. Daigle; Carol A. Zimmerman

353

Lagrange L4/L5 points and the origin of our Moon and Saturn's moons and rings.  

PubMed

The current standard theory of the origin of the Moon is that the Earth was hit by a giant impactor the size of Mars causing ejection of debris from its mantle that coalesced to form the moon; but where did this Mars-sized impactor come from? Isotopic evidence suggests that it came from 1 AU radius in the solar nebula, and computer simulations are consistent with its approaching Earth on a zero-energy parabolic trajectory. How could such a large object form at 1 AU in a quiescent disk of planetesimals without having already collided with the Earth at an earlier epoch before having the chance to grow large? Belbruno and Gott propose that the giant impactor could have formed in a stable orbit from debris at the Earth's Lagrange point L(5) (or L(4)). It would grow quietly by accretion at L(5) (or L(4)), but eventually gravitational perturbations by other growing planetesimals would kick it out into a horseshoe orbit and finally into a chaotic creeping orbit, which Belbruno and Gott show would, with high probability, hit the Earth on a near zero-energy parabolic trajectory. We can see other examples of this phenomenon occurring in the solar system. Asteroid 2002AA29 is in a horseshoe orbit relative to the Earth that looks exactly like the horseshoe orbits that Belbruno and Gott found for objects that had been perturbed from L(4)/L(5). The regular moons of Saturn are made of ice and have the same albedo as the ring particles (ice chunks, plus some dust). We (J. R. Gott, R. Vanderbei, and E. Belbruno) propose that the regular icy moons of Saturn (out to the orbit of Titan), which are all in nearly circular orbits, formed out of a thin disk of planetesimals (ice chunks) rather like the rings of Saturn today only larger in extent. In such a situation formation of objects at L(4)/L(5) might be expected. Indeed, Saturn's moon Dione is accompanied by moons (Helene and Polydeuces) at both L(4) and L(5) Lagrange points, and Saturn's moon Tethys is also accompanied by moons (Telesto and Calypso) at both L(4) and L(5) Lagrange points. Epimetheus is in a horseshoe orbit relative to Janus that is exactly like the horseshoe orbit expected for an object that has been perturbed from a location at L(4)/L(5). We propose that the rings of Saturn visible today are all that remains of this original disk; they lie inside the Roche limit where tidal forces have simply prevented the formation of large moons by accretion. Further out, the icy particles have accumulated into icy moons. Objects in external solar systems on horseshoe orbits (like those of Epimetheus relative to Janus) could be detected by a slow sinusoidal variation with time of the calculated mass of a planet from radial velocity measurements. PMID:16510418

Gott, J Richard

2005-12-01

354

Investigation of interleukin-6 (IL6), soluble IL6 receptor (sIL6R) and soluble gp130 (sgp130) in sera of cancer patients  

Microsoft Academic Search

The serum levels of interleukin-6 (IL-6), sIL-6R and sgp130 were investigated in 76 cancer patients in comparison with 28 healthy controls. IL-6 is a multifunctional cytokine involved in certain malignant diseases. Soluble IL-6 receptor as agonist enhances the biological effect of released IL-6. Soluble gp130 as antagonist inhibits the effect of the IL-6\\/sIL-6R complex. Patients with different types of tumour

E Kovacs

2001-01-01

355

A Quick Reference Guide to Parking The Parking Office is charged with managing the traffic and parking needs of the entire  

E-print Network

display a valid permit Parking on sidewalks or landscaped areas Blocking, moving, or parking within RowanA Quick Reference Guide to Parking The Parking Office is charged with managing the traffic and parking needs of the entire University community. To do this, we need your cooperation. Please take a few

Rusu, Adrian

356

Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4.  

PubMed Central

A unique characteristic of the localized inflammatory tissue in the periodontium (e.g., adult periodontitis [AP]) is the accumulation of IgG (IgG1 > IgG2 > IgG3 > or = IgG4) followed by IgA plasma cells (IgA1 > IgA2). However, the exact molecular mechanisms contributing to these elevated B-cell responses at the local disease site are still unknown. Thus, this study has examined the production of cytokines of importance in B-cell responses, e.g., interleukin (IL)-2, IL-4, IL-5, and IL-6 by gingival mononuclear cells (GMC) isolated from patients in severe stages of AP. These cytokines were assessed at the protein and messenger (m)RNA levels to understand their importance for the observed increased B-cell responses present in these tissues. Among the four cytokines tested by respective cytokine-specific, polymerase chain reaction and dot-blot hybridization, high levels of IL-5- and IL-6-specific mRNA were noted in GMC freshly isolated from AP patients. On the other hand, specific message for IL-2 and IL-4 were not present. Further, the analysis of culture supernatants of GMC also revealed that cells from AP patients spontaneously produced IL-5 and IL-6 but not IL-2 and IL-4. In contrast, when peripheral blood mononuclear cells isolated from the same patients were examined for these cytokines, no detectable levels of mRNA or secreted cytokines were noted. These results showed that GMC from localized inflammatory tissues in severe stages of AP possess a distinct cytokine profile represented by high levels of IL-5 and IL-6 mRNA expression and protein synthesis, whereas IL-2 and IL-4 were not detected. Further, this study supports the concept that AP is a localized inflammatory disease, because GMC from the inflamed tissue actively produce IL-5 and IL-6, whereas peripheral blood mononuclear cells from the same patients do not. Images Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 PMID:8475996

Fujihashi, K.; Beagley, K. W.; Kono, Y.; Aicher, W. K.; Yamamoto, M.; DiFabio, S.; Xu-Amano, J.; McGhee, J. R.; Kiyono, H.

1993-01-01

357

Species in Parks: Flora and Fauna Database  

NSDL National Science Digital Library

The Information Center of the Environment and the US National Park Service (NPS) have developed a "preliminary" data base of vascular plants and vertebrates located on National Park Service Lands. Although the database is not a complete list of species residing on NPS lands, it contains relatively complete lists for both small and large parks. Users can search for plants and animals by species or park name. Within each park, one can search a list of species by taxa (e.g., birds, mammals, fish, etc.) and then learn in what other parks that species is found. Links to the home pages for all NPS property (from American Samoa to Zion National Park) are featured. Both plant and animal databases are available for downloading for Windows or DOS users (.exe).

1997-01-01

358

The Geologic Story of Canyonlands National Park  

USGS Publications Warehouse

On September 12, 1964, President Lyndon B. Johnson signed an act of Congress establishing Canyonlands as our thirty second national park, the first addition to the park system since 1956. The birth of Canyonlands National Park was not without labor pains. In the 1930's virtually all the vast canyon country between Moab, Utah, and Grand Canyon, Ariz., was studied for a projected Escalante National Park. But Escalante failed to get off the ground, even when a second attempt was made in the 1950's. Not until another proposal had been made and legislative compromises had been worked out did the park materialize, this time under a new name - Canyonlands. Among the many dignitaries who witnessed the signature on September 12 was one of the men most responsible for the park's creation, park superintendent Bates E. Wilson, who did the pioneer spade work in the field.

Lohman, Stanley William

1974-01-01

359

Oncostatin M (OSM) primes IL-13- and IL-4-induced eotaxin responses in fibroblasts: regulation of the type-II IL-4 receptor chains IL-4Ralpha and IL-13Ralpha1.  

PubMed

Oncostatin M (OSM), a pleiotropic cytokine and a member of the gp130/IL-6 cytokine family, has been implicated in regulation of various chronic inflammatory processes. Previous work has shown that OSM induces eosinophil accumulation in mouse lungs in vivo and stimulates the eosinophil-selective chemokine eotaxin-1 synergistically with IL-4 in vitro. To examine the role of receptor regulation by OSM in synergistic eotaxin-1 responses, we here examine the modulation of the type-II IL-4 receptor (IL-4Ralpha and IL-13Ralpha1) by OSM and other gp130/IL-6 cytokine family members using NIH3T3 fibroblasts and primary mouse lung fibroblasts. We first show that OSM with either IL-13 or IL-4 synergistically induces eotaxin-1 expression in a dose-dependent fashion. Analysis of IL-4Ralpha expression at the protein (Western blot and FACS) and RNA (TAQMAN) levels showed that OSM markedly elevates expression by 3 h. OSM enhanced IL-13Ralpha1 mRNA and induced a smaller but detectable increase in total IL-13Ralpha1 protein. Priming fibroblasts with OSM for 6 h markedly enhanced subsequent IL-13 and IL-4-induced eotaxin-1 responses and STAT6 tyrosine-641 phosphorylation. Regulation of IL-4Ralpha by OSM was sensitive to inhibition of the PI3'K pathway by LY294002. These studies provide novel mechanistic insights in OSM role in regulation of synergistic eotaxin-1 responses and IL-4Ralpha expression in fibroblasts. PMID:19799897

Fritz, Dominik K; Kerr, Christine; Botelho, Fernando; Stampfli, Martin; Richards, Carl D

2009-12-10

360

Therapeutic opportunities of the IL-22-IL-22R1 system.  

PubMed

Interleukin-22 (IL-22) is a key effector molecule that is produced by activated T cells, including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate lymphoid cells. Although IL-22 can act synergistically with IL-17 or tumour necrosis factor, some important functions of IL-22 are unique to this cytokine. Data obtained over the past few years indicate that the IL-22-IL-22 receptor subunit 1 (IL-22R1) system has a high potential clinical relevance in psoriasis, ulcerative colitis, graft-versus-host disease, certain infections and tumours, as well as in liver and pancreas damage. This Review highlights current knowledge of the biology of the IL-22-IL-22R1 system, its role in inflammation, tissue protection, regeneration and antimicrobial defence, as well as the positive and potentially negative consequences of its therapeutic modulation. PMID:24378801

Sabat, Robert; Ouyang, Wenjun; Wolk, Kerstin

2014-01-01

361

IL-15 deficient tax mice reveal a role for IL-1? in tumor immunity.  

PubMed

IL-15 is recognized as a promising candidate for tumor immunotherapy and has been described as both a promoter of cancer and a promoter of anti-cancer immunity. IL-15 was discovered in cells transformed by HTLV-1, the etiologic agent of adult T cell leukemia/lymphoma (ATL) and the human retrovirus that carries the Tax oncogene. We have developed the TAX-LUC mouse model of ATL in which Tax expression drives both malignant transformation and luciferase expression, enabling non-invasive imaging of tumorigenesis in real time. To identify the role of IL-15 in spontaneous development of lymphoma in vivo, an IL-15(-/-) TAX-LUC strain was developed and examined. The absence of IL-15 resulted in aggressive tumor growth and accelerated mortality and demonstrated that IL-15 was not required for Tax-mediated lymphoma but was essential for anti-tumor immunity. Further analysis revealed a unique transcriptional profile in tumor cells that arise in the absence of IL-15 that included a significant increase in the expression of IL-1? and IL-1?-regulated cytokines. Moreover, anti-IL-1? antibodies and an IL-1 receptor antagonist (Anakinra) were used to interrogate the potential of IL-1? targeted therapies in this model. Taken together, these findings identify IL-15 and IL-1? as therapeutic targets in lymphoma. PMID:24416335

Rauch, Daniel A; Harding, John C; Ratner, Lee

2014-01-01

362

IL-15 Deficient Tax Mice Reveal a Role for IL-1? in Tumor Immunity  

PubMed Central

IL-15 is recognized as a promising candidate for tumor immunotherapy and has been described as both a promoter of cancer and a promoter of anti-cancer immunity. IL-15 was discovered in cells transformed by HTLV-1, the etiologic agent of adult T cell leukemia/lymphoma (ATL) and the human retrovirus that carries the Tax oncogene. We have developed the TAX-LUC mouse model of ATL in which Tax expression drives both malignant transformation and luciferase expression, enabling non-invasive imaging of tumorigenesis in real time. To identify the role of IL-15 in spontaneous development of lymphoma in vivo, an IL-15?/? TAX-LUC strain was developed and examined. The absence of IL-15 resulted in aggressive tumor growth and accelerated mortality and demonstrated that IL-15 was not required for Tax-mediated lymphoma but was essential for anti-tumor immunity. Further analysis revealed a unique transcriptional profile in tumor cells that arise in the absence of IL-15 that included a significant increase in the expression of IL-1? and IL-1?-regulated cytokines. Moreover, anti-IL-1? antibodies and an IL-1 receptor antagonist (Anakinra) were used to interrogate the potential of IL-1? targeted therapies in this model. Taken together, these findings identify IL-15 and IL-1? as therapeutic targets in lymphoma. PMID:24416335

Rauch, Daniel A.; Harding, John C.; Ratner, Lee

2014-01-01

363

25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways  

PubMed Central

Low vitamin D is involved in allergic asthma and rhinitis. IL-31 and IL-33 correlate with Th2-associated cytokines in allergic disease. We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of the airways. 25-Hydroxyvitamin D [25(OH) Vit D], IL-31, and IL-33 plasma levels were measured in 28 controls (HC), 11 allergic rhinitis (AR) patients, and 35 allergic asthma with rhinitis (AAR) patients. We found significant lower levels of 25(OH) Vit D in AR and in AAR than in HC. IL-31 and IL-33 plasma levels significantly increased in AAR than HC. IL-31 and IL-33 positively correlated in AR and AAR. 25(OH) Vit D deficient AAR had higher levels of blood eosinophils, exacerbations, disease duration, and total IgE than patients with insufficient or sufficient 25(OH) Vit D. In AAR 25(OH) Vit D levels inversely correlated with total allergen sIgE score and total atopy index. IL-31 and IL-33 did not correlate with 25(OH) Vit D in AR and AAR. In conclusion, low levels of 25(OH) Vit D might represent a risk factor for the development of concomitant asthma and rhinitis in children with allergic disease of the airways independently of IL-31/IL-33 Th2 activity. PMID:25061262

Bonanno, Anna; Gangemi, Sebastiano; La Grutta, Stefania; Malizia, Velia; Profita, Mirella

2014-01-01

364

The proinflammatory cytokines IL-2, IL-15 and IL-21 modulate the repertoire of mature human natural killer cell receptors.  

PubMed

Natural killer (NK) cells play a crucial role in the immune response to micro-organisms and tumours. Recent evidence suggests that NK cells also regulate the adaptive T-cell response and that it might be possible to exploit this ability to eliminate autoreactive T cells in autoimmune disease and alloreactive T cells in transplantation. Mature NK cells consist of a highly diverse population of cells that expresses different receptors to facilitate recognition of diseased cells and possibly pathogens themselves. Ex vivo culture of NK cells with cytokines such as IL-2 and IL-15 is an approach that permits significant expansion of the NK cell subpopulations, which are likely to have potent antitumour, antiviral, or immunomodulatory effects in autoimmunity. Our data indicate that the addition of IL-21 has a synergistic effect by increasing the numbers of NK cells on a large scale. IL-2 and IL-15 may induce the expression of killer cell immunoglobulin-like receptors (KIRs) in KIR-negative populations, the c-lectin receptor NKG2D and the natural cytotoxic receptor NKp44. The addition of IL-21 to IL-15 or IL-2 can modify the pattern of the KIR receptors and inhibit NKp44 expression by reducing the expression of the adaptor DAP-12. IL-21 also preserved the production of interferon-gamma and enhanced the cytotoxic properties of NK cells. Our findings indicate that the proinflammatory cytokines IL-2, IL-15 and IL-21 can modify the peripheral repertoire of NK cells. These properties may be used to endow subpopulations of NK cells with specific phenotypes, which may be used in ex vivo cellular immunotherapy strategies. PMID:18053164

de Rham, Casimir; Ferrari-Lacraz, Sylvie; Jendly, Sabrina; Schneiter, Gregory; Dayer, Jean-Michel; Villard, Jean

2007-01-01

365

IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells.  

PubMed

Osteosarcoma (OS) is the most common human primary malignant bone tumor in children and young adults with poor prognosis because of their high metastatic potential. Identification of key factors that could regulate the aggressive biologic behavior of OS, particularly with respect to metastasis, would be necessary if significant improvements in therapeutic outcome are to occur. In this study, we carefully evaluated the potential role of IL-17A/IL-17RA interaction in metastasis of OS. We found that serum IL-17A was higher in OS patients with metastasis and was associated with their clinical stage. The elevated expression of IL-17RA was observed in tumor tissue from OS patients with metastasis. Of note, we showed that IL-17A could promote the metastasis of U-2 OS cells which expression high IL-17RA, but not MG63 cells which expression low IL-17RA. Further, we revealed that downregulation of IL-17RA in U-2 cells could abrogated the enhanced metastasis induced by IL-17A, while upregulation of IL-17RA in MG63 cells could elevate their response to IL-17A and exerted enhanced metastasis. We observed that IL-17A/IL-17RA interaction promoted the expression of VEGF, MMP9 and CXCR4 in OS cells, which might partly explain the enhanced metastasis of OS cells. Furthermore, we showed that Stat3 activity was crucial for IL-17A/IL-17RA interaction to promote OS metastasis. Finally, we confirmed that IL-17A/IL-17RA interaction promoted the metastasis of OS in nude mice. Our findings might provide a mechanistic explanation for metastasis of OS in vivo, and suggested that targeting IL-17A signaling was a novel promising strategy to treat patients with OS. PMID:23192273

Wang, Mingmin; Wang, Luanqiu; Ren, Tao; Xu, Lin; Wen, Zhenke

2013-02-01

366

IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells  

PubMed Central

Osteosarcoma (OS) is the most common human primary malignant bone tumor in children and young adults with poor prognosis because of their high metastatic potential. Identification of key factors that could regulate the aggressive biologic behavior of OS, particularly with respect to metastasis, would be necessary if significant improvements in therapeutic outcome are to occur. In this study, we carefully evaluated the potential role of IL-17A/IL-17RA interaction in metastasis of OS. We found that serum IL-17A was higher in OS patients with metastasis and was associated with their clinical stage. The elevated expression of IL-17RA was observed in tumor tissue from OS patients with metastasis. Of note, we showed that IL-17A could promote the metastasis of U-2 OS cells which expression high IL-17RA, but not MG63 cells which expression low IL-17RA. Further, we revealed that downregulation of IL-17RA in U-2 cells could abrogated the enhanced metastasis induced by IL-17A, while upregulation of IL-17RA in MG63 cells could elevate their response to IL-17A and exerted enhanced metastasis. We observed that IL-17A/IL-17RA interaction promoted the expression of VEGF, MMP9 and CXCR4 in OS cells, which might partly explain the enhanced metastasis of OS cells. Furthermore, we showed that Stat3 activity was crucial for IL-17A/IL-17RA interaction to promote OS metastasis. Finally, we confirmed that IL-17A/IL-17RA interaction promoted the metastasis of OS in nude mice. Our findings might provide a mechanistic explanation for metastasis of OS in vivo, and suggested that targeting IL-17A signaling was a novel promising strategy to treat patients with OS. PMID:23192273

Wang, Mingmin; Wang, Luanqiu; Ren, Tao; Xu, Lin; Wen, Zhenke

2013-01-01

367

Energetics and Cooling in Urban Parks  

NASA Astrophysics Data System (ADS)

While there has been a long tradition for the integration of architecture and landscape to improve the urban environment, little is known about the effect of urban parks on local climate. In this study the park effect is determined through an integrated research approach incorporating field measurements of the thermal regime and energetics of urban parks, together with scale modelling of nocturnal cooling in urban parks. The research is limited to consideration of the park effect in two cities with different summer climates: Sacramento, California (hot summer Mediterranean) and Vancoucer, British Columbia (cool summer Mediterranean). In both these cities, surveys of summer-time air temperature patterns associated with urban parks confirm and extend previous findings. In temperate Vancouver, the park effect is typically 1-2^circC, rarely more than 3^circC, although it can be higher under ideal conditions. However, in a hot, dry city, the effect is considerably enhanced with parks as much as 5-7^circC cooler than their urban surrounds. A comparison of the surface energy balance of small open, grassed parks in these two cities demonstrated the importance of evapotranspiration in park energetics. In hot, dry Sacramento, evaporation in the park was advectively -assisted and exceeded that at an irrigated rural site. Strong advective edge effects on evaporation were observed in this wet park. These decayed approximately exponentially with distance into the park. The urban park in Vancouver was moist, but unirrigated. While evaporation dominated the surface energy balance, the sensible heat flux was positive through most of the day, and evaporation was not strongly influenced by advection. The evaporation trend in the park probably reflected the turbulence and soil moisture regimes. However, an irrigated lawn in Vancouver did exhibit edge-type advection. This suggests the soil moisture regime may be critical in determining whether evaporation exceeds the potential rate. The contribution of processes to nocturnal cooling in urban parks was determined through scale modelling. It showed that surface geometry and the urban-park difference in thermal admittance may be of equal importance in nocturnal cooling. Parks with high sky view factors have increased radiative cooling and if the park is very dry (and therefore has a low thermal admittance), the cooling is furthered enhanced. Evaporative cooling is critical in establishing the park as a "cool island" at sunset, but the presence of moisture slows cooling through the night. Integration of the field and model data leads to the development of guidelines for planners regarding the design of parks for maximum climatic benefit. The optimum size of the park depends to a large extent, on the geometry of the urban surrounds. To maximize radiative cooling, the width of open park areas should be at least 7.5 times the height of the trees or buildings around the park border. Larger parks increase the size of the volume of air cooled and this increases the potential for advection of cool air into the neighbourhood. It suggested that if cooling is the objective, the optimum design is a savannah -type park with loose clusters of trees interspersed by wide open, irrigated grass. The arrangement of trees must be chosen with great care to allow the advection of air both into, and out of, the park.

Spronken-Smith, Rachel Anne

368

IL-6, IL-10 and IL-13 are associated with pathogenesis in children with Enterovirus 71 infection  

PubMed Central

In the present study, the aim was to reveal the relationship of serum IL-6, IL-10 and IL-13 levels in patient with Enterovirus 71 (EV71) infection. To elucidate the role of immune mechanisms in the pathogenesis of Hand, foot, and mouth disease (HFMD), we analyzed the cytokine of 112 EV71-infected patients. A significant elevation of serum (interleukin) IL-6, IL-10 and IL-13 levels in patients with EV71 infection compare with Un-EV71 infection HFMD patient and Healthy individuals. The production of inflammatory cytokines was increased with disease clinical stage. In addition, the immunological consequences of these cytokine in patient with EV71 infection showed a downward trend after cure. These data suggested that EV71 infection significantly increased the release of circulating IL-6, IL-10 and IL-13. The systemic inflammatory response may play an important role in the pathogenesis of HFMD. Moreover, this study may be designed to evaluate the potential therapeutic of medicine in the treatment of patients with EV71 infection. PMID:25356130

Chen, Zhifeng; Li, Ruiqin; Xie, Zhichao; Huang, Guoqiang; Yuan, Qingchun; Zeng, Jincheng

2014-01-01

369

IL-13 but not IL-4 signaling via IL-4R? protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis  

PubMed Central

Interleukin 4 (IL-4) was shown to be tumor-promoting in full carcinogenesis studies using 3-methylcholanthrene (MCA). Because heretofore the role of IL-4 in DMBA/TPA (9,10-dimethyl-1,2-benz-anthracene/12-O-tetradecanoylphorbol-13-acetate) two-stage carcinogenesis was not studied, we performed such experiments using either IL-4?/? or IL-4R??/? mice. We found that IL-4R??/? but not IL-4?/? mice have enhanced papilloma formation, suggesting that IL-13 may be involved. Indeed, IL-13?/? mice developed more papillomas after exposure to DMBA/TPA than their heterozygous IL-13-competent littermate controls. However, when tested in a full carcinogenesis experiment, exposure of mice to 25 ?g of MCA, both IL-13?/? and IL-13+/? mice led to the same incidence of tumors. While IL-4 enhances MCA carcinogenesis, it does not play a measurable role in our DMBA/TPA carcinogenesis experiments. Conversely, IL-13 does not affect MCA carcinogenesis but protects mice from DMBA/TPA carcinogenesis. One possible explanation is that IL-4 and IL-13, although they share a common IL-4R? chain, regulate signaling in target cells differently by employing distinct JAK/STAT-mediated signaling pathways downstream of IL-13 or IL-4 receptor complexes, resulting in different inflammatory transcriptional programs. Taken together, our results indicate that the course of DMBA/TPA- and MCA-induced carcinogenesis is affected differently by IL-4 versus IL-13-mediated inflammatory cascades. PMID:24403255

Rothe, Michael; Quarcoo, David; Chashchina, Anna A; Bozrova, Svetlana V; Qin, Zhihai; Nedospasov, Sergei A; Blankenstein, Thomas; Kammertoens, Thomas; Drutskaya, Marina S

2013-01-01

370

Treatment of acoustic fluid-structure interaction by Localized Lagrange Multipliers and comparison to alternative interface coupling methods.  

SciTech Connect

This paper is a sequel on the topic of localized Lagrange multipliers (LLM) for applications of fluid-structure interaction (FSI) between finite-element models of an acoustic fluid and an elastic structure. The prequel paper formulated the spatial-discretization methods, the LLM interface treatment, the time-marching partitioned analysis procedures, and the application to 1D benchmark problems. Here, we expand on formulation aspects required for successful application to more realistic 2D and 3D problems. Additional topics include duality relations at the fluid-structure interface, partitioned vibration analysis, reduced-order modeling, handling of curved interface surfaces, and comparison of LLM with other coupling methods. Emphasis is given to non-matching fluid-structure meshes. We present benchmark examples that illustrate the benefits and drawbacks of competing interface treatments. Realistic application problems involving the seismic response of two existing dams are considered. These include 2D modal analyses of the Koyna gravity dam, transient-response analyses of that dam with and without reduced-order modeling, incorporation of nonlinear cavitation effects, and the 3D transient-response analysis of the Morrow Point arch dam.

Felippa, Carlos A. (University of Colorado, Boulder, CO); Sprague, Michael A. (University of California, Merced, CA); Ross, Michael R.; Park, K. C. (University of Colorado, Boulder, CO)

2008-11-01

371

International Space Station Centrifuge Rotor Models A Comparison of the Euler-Lagrange and the Bond Graph Modeling Approach  

NASA Technical Reports Server (NTRS)

The assembly and operation of the International Space Station (ISS) require extensive testing and engineering analysis to verify that the Space Station system of systems would work together without any adverse interactions. Since the dynamic behavior of an entire Space Station cannot be tested on earth, math models of the Space Station structures and mechanical systems have to be built and integrated in computer simulations and analysis tools to analyze and predict what will happen in space. The ISS Centrifuge Rotor (CR) is one of many mechanical systems that need to be modeled and analyzed to verify the ISS integrated system performance on-orbit. This study investigates using Bond Graph modeling techniques as quick and simplified ways to generate models of the ISS Centrifuge Rotor. This paper outlines the steps used to generate simple and more complex models of the CR using Bond Graph Computer Aided Modeling Program with Graphical Input (CAMP-G). Comparisons of the Bond Graph CR models with those derived from Euler-Lagrange equations in MATLAB and those developed using multibody dynamic simulation at the National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC) are presented to demonstrate the usefulness of the Bond Graph modeling approach for aeronautics and space applications.

Nguyen, Louis H.; Ramakrishnan, Jayant; Granda, Jose J.

2006-01-01

372

Transport modeling of sedimenting particles in a turbulent pipe flow using Euler-Lagrange large eddy simulation  

E-print Network

A volume-filtered Euler-Lagrange large eddy simulation methodology is used to predict the physics of turbulent liquid-solid slurry flow through a horizontal pipe. A dynamic Smagorinsky model based on Lagrangian averaging is employed to account for the sub-filter scale effects in the liquid phase. A fully conservative immersed boundary method is used to account for the pipe geometry on a uniform cartesian grid. The liquid and solid phases are coupled through volume fraction and momentum exchange terms. Particle-particle and particle-wall collisions are modeled using a soft-sphere approach. A series of simulations have been performed by varying the superficial liquid velocity to be consistent with the experimental data by Dahl et al. (2003). Depending on the liquid flow rate, a particle bed can form and develop different patterns, which are discussed in the light of various regime diagrams proposed in the literature. The fluctuation in the height of the liquid-bed interface is characterized to understand the sp...

Arolla, Sunil K

2014-01-01

373

Numerical Analysis of the Dynamics of Two- and Three-Dimensional Fluidized Bed Reactors using an Euler-Lagrange Approach  

SciTech Connect

Biomass thermochemical conversion, often done in fluidized beds, recently gained a lot of attention due to its potential to efficiently produce renewable liquid fuels. Optimization of reactor design and operating conditions, however, requires a fundamental understanding of bed dynamics. In this work, a numerical framework based on an Euler-Lagrange approach is developed and used to perform and analyze large-scale simulations of two- and three-dimensional periodic fluidized beds. Collisions are handled using a soft-sphere model. An efficient parallel implementation allows one to explicitly track over 30 million particles, which is representative of the number of particles found in lab-scale reactor, therefore demonstrating the capability of Lagrangian approaches to simulate realistic systems at that scale. An on-the-fly bubble identification and tracking algorithm is used to characterize bubble dynamics for inlet velocities up to 9 times the minimum fluidization velocity. Statistics for gas volume fraction, gas and particle velocities, bed expansion, and bubble size and velocity, is compared across the two- and three-dimensional configurations, and comparison with literature data generally shows good agreement. The wide distribution of gas residence times observed in the simulations is linked to the different gas hold-up characteristics of the gas-solid system.

Pepiot, P.; Desjardins, O.

2012-04-01

374

National Park Service Web Cameras  

NSDL National Science Digital Library

The National Park Service (NPS) operates digital cameras at many parks in the lower 48 states, Alaska, and Hawaii to help educate the public on air quality issues. These cameras often show the effects of air pollution, especially visibility impairment. Because the cameras are typically located near air quality monitoring sites, their web pages display other information along with the photo, such as current levels of ozone, particulate matter, or sulfur dioxide, visual range, and weather conditions. The digital photos are usually updated every 15 minutes, while air quality data values are revised hourly. Charts of the last ten days of hourly weather, ozone, particulate matter, or sulfur dioxide data are also available. The cameras are accessible by clicking on an interactive map.

375

National Association for Olmsted Parks  

NSDL National Science Digital Library

Established in 1980, the National Association for Olmsted Parks (NAOP) is a coalition of various design and preservation professionals concerned with the legacy of landscape work left by noted landscape designer Frederick Law Olmsted Sr. and his colleagues. On their website, visitors can learn about Olmsted's primary works via a master list of design projects by his firm and some profiles of some of his most prominent work, including Central Park and the landscape at the Biltmore Estate. Scholars will want to look through the "Research" area for resources that include a set of suggested links and an extensive bibliography. Visitors will also want to look at the "News and Publications" area for more details about the NAOP's work and their newsletter.

376

Buddingtonite in Menlo Park, California  

USGS Publications Warehouse

The mineral buddingtonite, named after A.F. Buddington, long-time professor of petrology at Princeton University, was first identified at the Sulfur Bank mine in Lake County, California (Erd and others, 1964). The ammonium feldspar was recognized in Menlo Park, California, in 1964 by the author, with Erd's help, shortly before publication of the original description of the new mineral. Subsequently, buddingtonite has been widely recognized in hydrothermal mineral deposits and has been used in remote-sensing applications by the mineral industry. Buddingtonite also has been identified in the Phosphoria Formation and in oil shales of the Green River Formation. This paper briefly describes the geologic setting and mineralogy of the occurrences of buddingtonite and other ammonium-bearing minerals in the vicinity of Menlo Park.

Pampeyan, Earl H.

2010-01-01

377

HUSTON PARK ROADLESS AREA, WYOMING.  

USGS Publications Warehouse

A probable resource potential for the occurrence of metallic mineral resources in stratiform sulfide deposits is assigned to areas in the northern and southeastern parts of the Huston Park Roadless Area, Wyoming. These areas are underlain by volcanic rock successions favorable for stratiform sulfide deposits. However, no indication of mineralized rock was identified during a mineral survey. Study of granites of the southern Sierra Madre are needed to determine whether or not they have promise as a source of tin and tungsten.

Houston, Robert, S.; Lane, Michael, E.

1984-01-01

378

Coordinating OBS Parks in Europe  

NASA Astrophysics Data System (ADS)

Within Europe there are more than 380 Ocean Bottom Seismometers (OBS) distributed across 10 instrument parks in 6 countries. At least 120 of these OBS are wideband or broadband, over 260 can be deployed for at least 6 months at a time and 140 for at least one year. New parks are planned in two other European countries, which should add over 70 OBSs to this "fleet". However, these parks are under the control of individual countries or universities and hence to date this has made it difficult to organize large-scale experiments, especially for seismologists without marine experience. There has recently been an initiative to coordinate the use of these distributed instruments and their data products, to encourage large-scale experiments, possibly with onshore and offshore components, by seismologists who have not necessarily used OBSs before. The ongoing or planned developments include: Helping scientists with marine-specific formalities such as ship requests; clearer explanations of the noise floors of OBS instrumentation; improved clarity of instrument pricing and availability; standardized data output formats and data validation; and archiving in established seismological data centers. These efforts should allow improved experiment design in scientifically interesting regions with an offshore component and an easier, clearer way to organize large-scale, multi-country experiments. We will present details of this initiative to help organize large-scale experiments, the particularities of OBS sensors and marine deployments, the available instrumentation and new developments.

Crawford, W.; Brisbourne, A.; D'Anna, G.; Flüh, E. R.; Galve, A.; Graindorge, D.; Harmon, N.; Henstock, T.; Klingelhöfer, F.; Mangano, G.; Matias, L.; Peirce, C.; Sallares, V.; Schmidt-Aursch, M.; Tilmann, F.; Voss, P.

2012-04-01

379

Pro-Inflammatory Signaling by IL-10 and IL-22: Bad Habit Stirred Up by Interferons?  

PubMed Central

Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of transcription (STAT)-3 as dominant signaling mode. IL-10, formerly known as cytokine synthesis inhibitory factor, is key to deactivation of monocytes/macrophages and dendritic cells. Accordingly, pre-clinical studies document its anti-inflammatory capacity. However, the outcome of clinical trials assessing the therapeutic potential of IL-10 in prototypic inflammatory disorders has been disappointing. In contrast to IL-10, IL-22 acts primarily on non-leukocytic cells, in particular epithelial cells of intestine, skin, liver, and lung. STAT3-driven proliferation, anti-apoptosis, and anti-microbial tissue protection is regarded a principal function of IL-22 at host/environment interfaces. In this hypothesis article, hidden/underappreciated pro-inflammatory characteristics of IL-10 and IL-22 are outlined and related to cellular priming by type I interferon. It is tempting to speculate that an inherent inflammatory potential of IL-10 and IL-22 confines their usage in tissue protective therapy and beyond that determines in some patients efficacy of type I interferon treatment. PMID:23382730

Muhl, Heiko

2013-01-01

380

Parking, energy consumption and air pollution.  

PubMed

This paper examines the impacts of different ways of parking on environmental effects, mainly vehicle emissions and air pollution. Vehicle energy consumption and the urban air quality at street level, related to location and design of parking establishments, need to be assessed and quantified. In addition, the indoor parking environment needs attention. This paper gives a description of a methodological approach when comparing different parking establishments. The paper also briefly describes a Swedish attempt to create methods and models for assessing and quantifying such problem. The models are the macrolevel model BRAHE, for regional traffic exhaust emission, and the micromodel SimPark, a parking search model attempt combined with emission models. Until now, very limited knowledge exists regarding the various aspects of vehicle parking and environmental effects in the technical field as well as in the social and human behaviour aspects. This requires an interdisciplinary approach to this challenging area for research, development and more directly practically implemented surveys and field studies. In order to illustrate the new evaluation methodology, the paper also contains some results from a pilot study in Stockholm. Given certain assumptions, a study of vehicle emissions from parking in an underground garage compared with kerbside parking has given an emission reduction of about 40% in favour of the parking garage. This study has been done using the models mentioned above. PMID:15504491

Höglund, Paul G

2004-12-01

381

75 FR 20859 - Notice of Realty Action, Independence National Historical Park, Pennsylvania and Valley Forge...  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF THE INTERIOR National Park Service Notice of Realty Action, Independence National Historical Park, Pennsylvania and Valley Forge National Historical Park, Pennsylvania AGENCY: National Park Service,...

2010-04-21

382

Untangling the Complex Web of IL-4- and IL-13-Mediated Signaling Pathways  

NSDL National Science Digital Library

Unraveling the exact signaling events mediating the distinct functions of the T cell–derived cytokines interleukin-4 (IL-4) and IL-13 has been challenging because they are structurally similar and share a functional signaling receptor chain. A study now proposes a potential molecular mechanism to explain the functional differences between IL-4 and IL-13 that involves the ability of IL-4, but not IL-13, to effectively activate the insulin receptor substrate–2 (IRS-2) signaling cascade through binding to its receptor. A better understanding of the interactions of IL-4 and IL-13 with their cognate receptors may facilitate the development of therapies without unintended side effects.

Marsha Wills-Karp (Cincinnati Children's Hospital Medical Center;Division of Immunobiology REV); Fred D. Finkelman (Cincinnati Children's Hospital Medical Center;Division of Immunobiology REV)

2008-12-23

383

Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours.  

PubMed

Interleukin-7 (IL-7) plays an important role in the normal development and maintenance of the human immune system. Its effects are mediated via its receptor, IL-7R. Ligand-receptor engagement results in a cascade of phosphorylation events mediated by various molecules including the Janus kinases (Jak1 and Jak3), PI3-kinase, Stats (signal transducers and activators of transcription) and other molecules. The activation of IL-7 signalling pathway results in survival, proliferation, differentiation and maturation of haematopoietic cells including B and T lymphocytes. Although the relationship of IL-7 with the development and differentiation of some haematological cancers like leukaemias and lymphomas is well recognised, little is known about it involvement with solid tumours. There are several studies that have revealed IL-7/IL-7R expression in epithelial systems and some human solid epithelial tumours. Furthermore, IL-7 can be produced by some human tumour cells and involved in tumour development and progression. In this review article we have summarised the main biological activities of IL-7 and its downstream signalling complex in relation to some human solid malignancies. PMID:12792903

Al-Rawi, M A A; Mansel, R E; Jiang, W G

2003-07-01

384

Prognostic significance of IL-6 and IL-8 ascites levels in ovarian cancer patients  

PubMed Central

Background The acellular fraction of epithelial ovarian cancer (EOC) ascites promotes de novo resistance of tumor cells and thus supports the idea that tumor cells may survive in the surrounding protective microenvironment contributing to disease recurrence. Levels of the pro-inflammatory cytokines IL-6 and IL-8 are elevated in EOC ascites suggesting that they could play a role in tumor progression. Methods We measured IL-6 and IL-8 levels in the ascites of 39 patients with newly diagnosed EOC. Commercially available enzyme-linked immunosorbent assay (ELISA) was used to determine IL-6 and IL-8 ascites levels. Ascites cytokine levels were correlated with clinicopathological parameters and progression-free survival. Results Mean ascites levels for IL-6 and IL-8 were 6419 pg/ml (SEM: 1409 pg/ml) and 1408 pg/ml (SEM: 437 pg/ml) respectively. The levels of IL-6 and IL-8 in ascites were significantly lower in patients that have received prior chemotherapy before the surgery (Mann-Whitney U test, P = 0.037 for IL-6 and P = 0.008 for IL-8). Univariate analysis revealed that high IL-6 ascites levels (P = 0.021), serum CA125 levels (P = 0.04) and stage IV (P = 0.009) were significantly correlated with shorter progression-free survival. Including these variables in a multivariate analysis revealed that elevated IL-6 levels (P = 0.033) was an independent predictor of shorter progression-free survival. Conclusion Elevated IL-6, but not IL-8, ascites level is an independent predictor of shorter progression-free survival. PMID:21619709

2011-01-01

385

Comparison in the effects of IL2, IL12, IL15 and IFN? on gene regulation of granzymes of human NK cell line NK92  

Microsoft Academic Search

Serine protease granzymes (GZM) are key effector molecules of granule-mediated cytotoxicity of NK cell, but the requirement for their expression regulation remains largely undefined. In this study, it was showed that IL-2, IL-12, IL-15 and IFN? differently regulated the expression of granzymes in NK cells. Although IL-2, IL-12, IL-15 and IFN? exerted overlapping positive effects on transcripts of GZM-A and

Bin Zhang; Jian Zhang; Zhigang Tian

2008-01-01

386

National Park Service, Nature & Science: Teacher Resources  

NSDL National Science Digital Library

The National Park Service has developed this exemplary set of educational resources which draws on their greatest assets, namely national parks from Maine to Utah. The materials are specifically designed for teaching geology, but it's easy to see how these items could be incorporated into general science classes. The main area on their homepage features over a dozen teacher guides and park programs that feature detailed geology lessons that draw on the landscapes of Yosemite National Park and the dynamic volcanoes of Hawaii. On the right side of the page, visitors can scan through the "Highlights" area to learn more about online park images, park maps, and even peruse a calendar of upcoming educator workshops. The site is rounded out by the "Geology Books and Media" area, which features information about technical reports, textbooks, and geology-themed children's books.

387

Geology Fieldnotes: Theodore Roosevelt National Park, North Dakota  

NSDL National Science Digital Library

This Theodore Roosevelt National Park site contains park geology information, park maps, photographs, related links, visitor information, and teacher features (resources for teaching geology with National Park examples). The park geology section discusses the Park's geologic history and the region's role in shaping Theodore Roosevelt's conservation efforts while he was President. The section also contains a link to information on the geology of Theodore Roosevelt National Park. The park maps section contains an area map as well as two maps detailing the North and South Units of the Park.

388

41 CFR 102-74.270 - Are vehicles required to display parking permits in parking facilities?  

Code of Federal Regulations, 2011 CFR

...Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 74-FACILITY MANAGEMENT Facility Management Parking Facilities § 102-74.270 Are vehicles required to display parking permits in...

2011-01-01

389

A complicated liaison: IL-33 and IL-33R in arthritis pathogenesis.  

PubMed

Interruption of cytokine signaling, by targeting either the cytokine itself or its cellular receptor, is a mainstay in the therapy for patients with rheumatic diseases. Interleukin (IL)-33, a member of the IL-1 cytokine family, has emerged as an important mediator of inflammatory responses. In a side-by-side examination of IL-33-deficient and IL-33 receptor (IL-33R)-deficient mice in the K/BxN serum transfer model, arthritis was ameliorated in the IL-33R knockout (KO) mice but not in the IL-33 KO mice. These findings complement previous knowledge on IL-33R signaling, demonstrating that the IL-33R cross-activates other signaling pathways in addition to IL-33-mediated signals. The results reported by Martin and colleagues in a previous issue of Arthritis Research & Therapy underline the clinical relevance of IL-33R cross-signaling and further illustrate that targeting a cytokine receptor (IL-33R) can have completely different clinical outcomes than targeting the respective cytokine. PMID:23638884

Kamradt, Thomas; Drube, Sebastian

2013-01-01

390

Autoimmunity: regulatory B cells--IL-35 and IL-21 regulate the regulators.  

PubMed

IL-21 regulates the activity and number of IL-10-producing regulatory B cells (B10 cells) that modulate immune responses and limit diverse autoimmune diseases. A new study demonstrates that IL-35 has a similar function. Identifying regulatory circuits that control B10-cell function in vivo might open the door to future treatments for autoimmune diseases. PMID:24934192

Tedder, Thomas F; Leonard, Warren J

2014-08-01

391

Eccrine Sweat Contains IL-1?, IL-1? and IL-31 and Activates Epidermal Keratinocytes as a Danger Signal  

PubMed Central

Eccrine sweat is secreted onto the skin's surface and is not harmful to normal skin, but can exacerbate eczematous lesions in atopic dermatitis. Although eccrine sweat contains a number of minerals, proteins, and proteolytic enzymes, how it causes skin inflammation is not clear. We hypothesized that it stimulates keratinocytes directly, as a danger signal. Eccrine sweat was collected from the arms of healthy volunteers after exercise, and levels of proinflammatory cytokines in the sweat were quantified by ELISA. We detected the presence of IL-1?, IL-1?, and high levels of IL-31 in sweat samples. To investigate whether sweat activates keratinocytes, normal human keratinocytes were stimulated with concentrated sweat. Western blot analysis demonstrated the activation of NF-?B, ERK, and JNK signaling in sweat-stimulated keratinocytes. Real-time PCR using total RNA and ELISA analysis of supernatants showed the upregulation of IL-8 and IL-1? by sweat. Furthermore, pretreatment with IL-1R antagonist blocked sweat-stimulated cytokine production and signal activation, indicating that bioactive IL-1 is a major factor in the activation of keratinocytes by sweat. Moreover, IL-31 seems to be another sweat stimulator that activates keratinocytes to produce inflammatory cytokine, CCL2. Sweat is secreted onto the skin's surface and does not come into contact with keratinocytes in normal skin. However, in skin with a defective cutaneous barrier, such as atopic dermatitis-affected skin, sweat cytokines can directly act on epidermal keratinocytes, resulting in their activation. In conclusion, eccrine sweat contains proinflammatory cytokines, IL-1 and IL-31, and activates epidermal keratinocytes as a danger signal. PMID:23874436

Dai, Xiuju; Okazaki, Hidenori; Hanakawa, Yasushi; Murakami, Masamoto; Tohyama, Mikiko; Shirakata, Yuji; Sayama, Koji

2013-01-01

392

Geology Fieldnotes: Arches National Park, Utah  

NSDL National Science Digital Library

This park is located on the Colorado Plateau near Moab, Utah, and contains many arches and sculpted sedimentary rocks. The visible rock formations in the park are the Entrada and Navajo sandstones. Covered topics include the formation of arches in stages, different types of arches, as well as sizes and names (Delicate Arch being the most famous). The site also provides visitor information, photos, maps, additional links, and a teacher feature (tools for teaching geology with National Park examples).

Foos, Annabelle

393

Evaluation of Noise Pollution in Urban Parks  

Microsoft Academic Search

The present study provides an evaluation of noise pollution in six Urban Parks located in the city of Curitiba, Brazil. Equivalent\\u000a noise levels (L\\u000a eq) were measured in 303 points (each point measured during 3 min) spread throughout the Parks. Measured values were confronted\\u000a with local legislation (Law 10625) allowed limits, and the Parks were thus classified as “acoustically polluted

Paulo Henrique Trombetta Zannin; Andressa Maria Coelho Ferreira; Bani Szeremetta

2006-01-01

394

An analysis of Utah State Park visitors  

E-print Network

AN ANALYSIS OF UTAH STATE PARK VISITORS A PROFESSIONAL PAPER by DENNIS C. BURNS Submitted to the College of Agriculture of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF AGRICULTURE December..., 1988 Major Subject: Recreation and Resources Development Department of Recreation and Parks AN ANALYSIS OF UTAH STATE PARK VISITORS A PROFESSIONAL PAPER by DENNIS C. BURNS Approved as to style and content by: Dr. Ronald A. Kaiser Chairman...

Burns, Dennis C.

2012-06-07

395

updated August 1, 2012 -Motorcycle Parking  

E-print Network

44 28 20 13 2525 16 26 5250 51 53 9C 42 38R 38R 3D 3B 3A 4 3E 46 46 9A32 33 30 31 46 19 33T LOT 38F Parking - Metered Parking Campus Districts Academics Athletics Residence Halls R&D Park Health Services Union CRU Andros Center RAN Zeta Hall RZE Eta Hall RET Mu Hall RMU University Police UPB Campus Business

Meyers, Steven D.

396

USGS Repeat Photography Project: Glacier National Park  

NSDL National Science Digital Library

This project, conducted by the United States Geological Survey (USGS), documents changes over time in the landscape of Glacier National Park, particularly the retreat of the park's glaciers. The project involves pairing historic photos from the park's archives with recent photos to illustrate how the landscape has changed. Users can view and download the photos in pairs with dates and a caption describing the scene and the changes that have taken place.

2010-11-22

397

Discovery Park's Office of Engagement Impact Summary/Summer 2008  

E-print Network

Discovery Park's Office of Engagement Impact Summary/Summer 2008 Discovery Park's Office-time. The Associate Director's appointment is shared and spans Discovery Park, the Purdue Research Parks, and the Office of Engagement. Thus, the intent of this role is to connect Discovery Park activities

Holland, Jeffrey

398

Geology Fieldnotes: Death Valley National Park, California/Nevada  

NSDL National Science Digital Library

This Death Valley National Park site contains park geology information, park maps, photographs, visitor information, and teacher features (resources for teaching geology using National Park examples). The Park Geology section contains an exaggerated cross-section showing the vertical rise within Death Valley. A link is provided to Death Valley's expanded geology page.

399

THE UNIVERSITY OF TENNESSEE AT KNOXVILLE PARKING AND TRANSPORTATION INFORMATION  

E-print Network

of the restricted/reserved lots. In areas with parking limited by time such as Circle Park (45 minutes), anyone of the vehicle. · The T-Access paratransit service can pick-up from all parking areas, although this may require parking is available in the parking area west of Perkins. #12;· The 11th Street Garage is available

Tennessee, University of

400

Parking Functions And Generalized Catalan Numbers  

E-print Network

to parking preferences of i and the (at most one) diagonal step at position i corresponds to a block on i, this means that, if we translate the path into a parking function, we have at least i preferences and blocks less than i (for all i ? n). Thus, the Schr... to parking preferences of i and the (at most one) diagonal step at position i corresponds to a block on i, this means that, if we translate the path into a parking function, we have at least i preferences and blocks less than i (for all i ? n). Thus, the Schr...

Schumacher, Paul R.

2010-01-14

401

75 FR 20885 - National Park Week, 2010  

Federal Register 2010, 2011, 2012, 2013

...Proclamation 8498--National Park Week, 2010 Proclamation 8499--National Crime Victims' Rights Week, 2010 Proclamation 8500--National Volunteer Week, 2010 Proclamation 8501--National Day of Service and...

2010-04-21

402

IL-1 blockade in autoinflammatory syndromes.  

PubMed

Monogenic autoinflammatory syndromes present with excessive systemic inflammation including fever, rashes, arthritis, and organ-specific inflammation and are caused by defects in single genes encoding proteins that regulate innate inflammatory pathways. Pathogenic variants in two interleukin-1 (IL-1)-regulating genes, NLRP3 and IL1RN, cause two severe and early-onset autoinflammatory syndromes, CAPS (cryopyrin associated periodic syndromes) and DIRA (deficiency of IL-1 receptor antagonist). The discovery of the mutations that cause CAPS and DIRA led to clinical and basic research that uncovered the key role of IL-1 in an extended spectrum of immune dysregulatory conditions. NLRP3 encodes cryopyrin, an intracellular "molecular sensor" that forms a multimolecular platform, the NLRP3 inflammasome, which links "danger recognition" to the activation of the proinflammatory cytokine IL-1?. The success and safety profile of drugs targeting IL -1 in the treatment of CAPS and DIRA have encouraged their wider use in other autoinflammatory syndromes including the classic hereditary periodic fever syndromes (familial Mediterranean fever, TNF receptor-associated periodic syndrome, and hyperimmunoglobulinemia D with periodic fever syndrome) and additional immune dysregulatory conditions that are not genetically well defined, including Still's, Behcet's, and Schnitzler diseases. The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1?-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease. PMID:24422572

Jesus, Adriana A; Goldbach-Mansky, Raphaela

2014-01-01

403

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6  

PubMed Central

Interleukin-6 (IL-6) is a cytokine with many activities. It has functions in the regulation of the immune system and the nervous system. Furthermore, IL-6 is involved in liver regeneration and in the metabolic control of the body. On target cells, IL-6 binds to an 80 kDa IL-6 receptor (IL-6R). The complex of IL-6 and IL-6R associates with a second protein, gp130, which thereupon dimerizes and initiates intracellular signaling. Whereas gp130 is expressed on all cells, IL-6R is only present on few cells in the body including hepatocytes and some leukocytes. Cells, which do not express IL-6R cannot respond to the cytokine, since gp130 alone has no measurable affinity for IL-6. Interestingly, a soluble form of IL-6R (sIL-6R) comprising the extracellular portion of the receptor can bind IL-6 with a similar affinity as the membrane bound IL-6R. The complex of IL-6 and sIL-6R can bind to gp130 on cells, which do not express the IL-6R, and which are unresponsive to IL-6. This process has been called trans-signaling. Here I will review published evidence that IL-6 trans-signaling is pro-inflammatory whereas classic IL-6 signaling via the membrane bound IL-6R is needed for regenerative or anti-inflammatory activities of the cytokine. Furthermore, the detailed knowledge of IL-6 biology has important consequences for therapeutic strategies aimed at the blockade of the cytokine IL-6. PMID:23136552

Rose-John, Stefan

2012-01-01

404

Feasibility of cooling the Earth with a cloud of small spacecraft near the inner Lagrange point (L1).  

PubMed

If it were to become apparent that dangerous changes in global climate were inevitable, despite greenhouse gas controls, active methods to cool the Earth on an emergency basis might be desirable. The concept considered here is to block 1.8% of the solar flux with a space sunshade orbited near the inner Lagrange point (L1), in-line between the Earth and sun. Following the work of J. Early [Early, JT (1989) J Br Interplanet Soc 42:567-569], transparent material would be used to deflect the sunlight, rather than to absorb it, to minimize the shift in balance out from L1 caused by radiation pressure. Three advances aimed at practical implementation are presented. First is an optical design for a very thin refractive screen with low reflectivity, leading to a total sunshade mass of approximately 20 million tons. Second is a concept aimed at reducing transportation cost to 50 dollars/kg by using electromagnetic acceleration to escape Earth's gravity, followed by ion propulsion. Third is an implementation of the sunshade as a cloud of many spacecraft, autonomously stabilized by modulating solar radiation pressure. These meter-sized "flyers" would be assembled completely before launch, avoiding any need for construction or unfolding in space. They would weigh a gram each, be launched in stacks of 800,000, and remain for a projected lifetime of 50 years within a 100,000-km-long cloud. The concept builds on existing technologies. It seems feasible that it could be developed and deployed in approximately 25 years at a cost of a few trillion dollars, <0.5% of world gross domestic product (GDP) over that time. PMID:17085589

Angel, Roger

2006-11-14

405

The Augmented Lagrange Multipliers Method for Matrix Completion from Corrupted Samplings with Application to Mixed Gaussian-Impulse Noise Removal  

PubMed Central

This paper studies the problem of the restoration of images corrupted by mixed Gaussian-impulse noise. In recent years, low-rank matrix reconstruction has become a research hotspot in many scientific and engineering domains such as machine learning, image processing, computer vision and bioinformatics, which mainly involves the problem of matrix completion and robust principal component analysis, namely recovering a low-rank matrix from an incomplete but accurate sampling subset of its entries and from an observed data matrix with an unknown fraction of its entries being arbitrarily corrupted, respectively. Inspired by these ideas, we consider the problem of recovering a low-rank matrix from an incomplete sampling subset of its entries with an unknown fraction of the samplings contaminated by arbitrary errors, which is defined as the problem of matrix completion from corrupted samplings and modeled as a convex optimization problem that minimizes a combination of the nuclear norm and the -norm in this paper. Meanwhile, we put forward a novel and effective algorithm called augmented Lagrange multipliers to exactly solve the problem. For mixed Gaussian-impulse noise removal, we regard it as the problem of matrix completion from corrupted samplings, and restore the noisy image following an impulse-detecting procedure. Compared with some existing methods for mixed noise removal, the recovery quality performance of our method is dominant if images possess low-rank features such as geometrically regular textures and similar structured contents; especially when the density of impulse noise is relatively high and the variance of Gaussian noise is small, our method can outperform the traditional methods significantly not only in the simultaneous removal of Gaussian noise and impulse noise, and the restoration ability for a low-rank image matrix, but also in the preservation of textures and details in the image. PMID:25248103

Meng, Fan; Yang, Xiaomei; Zhou, Chenghu

2014-01-01

406

Azimuthal extent and properties of midtail plasmoids from two-point ARTEMIS observations at the Earth-Moon Lagrange points  

NASA Astrophysics Data System (ADS)

distant-tail plasmoids are perceived to extend across most of the magnetotail (~40 RE), recent studies in the near-Earth region (X > -30 RE) have revealed that near-Earth reconnection (where plasmoids originate) is likely localized and takes place preferentially on the duskside. This discrepancy in plasmoid azimuthal extent suggests that a plasmoid may grow as it moves from near-Earth to the distant tail. Comprehensive multipoint, midtail plasmoid observations can be used to test this hypothesis. Between October 2010 and July 2011 the ARTEMIS spacecraft (P1 and P2) at the Earth-Moon Lagrange points (midtail, X ~ -45 to -65 RE) provided simultaneous two-point observations across the magnetotail for 4 days every lunar month, with a large range of spacecraft separations (0.1 to 25 RE). We find that plasmoids near lunar orbit, like other near-Earth reconnection-related phenomena, occur preferentially on the duskside of the magnetotail. Two-point ARTEMIS observations reveal that the typical plasmoid azimuthal size in our data set is about 5 to 10 RE, much smaller than expected from previous distant-tail observations. Plasmoids with an azimuthal size greater than 9 RE also exist but only at geomagnetic activity levels higher (AEpeak > 400 nT) than typically found in our data set (median AEpeak ~ 230 nT for our plasmoid data set and median AE ~ 100 nT during the entire period of ARTEMIS magnetotail observations). We conclude that plasmoids during small to moderate substorms (AEpeak < 400 nT) do not grow beyond ~10 RE until they have moved tailward of ~ -45 to -65 RE. Plasmoids during large substorms (AEpeak > 400 nT), however, either grow beyond ~10 RE before they reach lunar distance or initially extend across a large portion of the magnetotail.

Li, S.-S.; Angelopoulos, V.; Runov, A.; Kiehas, S. A.

2014-03-01

407

Differential Modulation by IL-17A of Cholangitis versus Colitis in IL-2R? Deleted Mice  

PubMed Central

IFN-? is a signature Th1 cell associated cytokine critical for the inflammatory response in autoimmunity with both pro-inflammatory and potentially protective functions. IL-17A is the hallmark of T helper 17 (Th17) cell subsets, produced by ??T, CD8+ T, NK and NKT cells. We have taken advantage of our colony of IL-2R??/? mice that spontaneously develop both autoimmune cholangitis and inflammatory bowel disease. In this model CD8+ T cells mediate biliary ductular damage, whereas CD4+ T cells mediate induction of colon-specific autoimmunity. Importantly, IL-2R??/? mice have high levels of interferon ? (IFN-?), and interleukin-17A (IL-17A). We produced unique double deletions of mice that were either IL-17A?/?IL-2R??/? or IFN-??/?IL-2R??/? to specifically address the precise role of these two cytokines in the natural history of autoimmune cholangitis and colitis. Of note, deletion of IL-17A in IL-2R??/? mice led to more severe liver inflammation, but ameliorated colitis. In contrast, there were no significant changes in the immunopathology of double knock-out IFN-??/? IL-2R??/? mice, compared to single knock-out IL-2R??/? mice with respect to cholangitis or colitis. Furthermore, there was a significant increase in pathogenetic CD8+ T cells in the liver of IL-17A?/?IL-2R??/? mice. Our data suggest that while IL-17A plays a protective role in autoimmune cholangitis, it has a pro-inflammatory role in inflammatory bowel disease. These data take on particular significance in the potential use of anti-IL-17A therapy in humans with primary biliary cirrhosis. PMID:25133396

Yang, Yan-Qing; Lu, Fang-Ting; Li, Liang; Wang, Yin-Hu; Nakajima, Takahiko; Tsuneyama, Koichi; Ridgway, William M.; Gershwin, M. Eric; Lian, Zhe-Xiong

2014-01-01

408

Pupils and Parks: Environmental Education in National Parks of Developing Countries.  

ERIC Educational Resources Information Center

Describes two conservation education programs that target local primary schools and use national parks in Malaysian Borneo (Kinabalu Park) and central Brazil (Morro do Diabo Park). Both were designed using a comprehensive systems evaluation model and both resulted in cognitive and affective gains for students. (LB)

Jacobson, Susan K.; Padua, Suzana M.

1992-01-01

409

Parks as Resources for Knowledge in Science (PARKS) National Program Evaluation Final Report.  

ERIC Educational Resources Information Center

This document evaluates the Parks as Resources for Knowledge in Science (PARKS) project which supports environmental education in 36 National Parks across the United States and provides curriculum-based learning opportunities that integrate National Science Education Standards for teachers and students. Contents include: (1) "Executive…

Wiltz, L. Kate

410

Parking for admissions interviews The Office of Undergraduate Admissions has two parking  

E-print Network

. municiPal garages B (at Second Street, between River and Hudson) D (at 215 Hudson Street, between Second/transportation-parking/municipal-parking-garages/. From each garage, go to Hudson Street and turn right. At Fourth Street, you will come to a park. Cut

Yang, Eui-Hyeok

411

Smart Parking Management Pilot Project: A Bay Area Rapid Transit (BART) District Parking Demonstration  

E-print Network

AND HIGHWAYS CALIFORNIA PATH PROGRAM INSTITUTE OF TRANSPORTATION STUDIES UNIVERSITY OF CALIFORNIA, BERKELEY SMARTsmart parking management contractor, ParkingCarma TM worked with California Partners for Advanced Transit and Highways (Smart Park proposal for the Santa Clara Valley Transit Authority (VTA) along Highway

Shaheen, Susan; Rodier, Caroline; Eaken, Amanda M.

2005-01-01

412

Smart Parking Management Field Test: A Bay Area Rapid Transit (BART) District Parking Demonstration; Final Report  

Microsoft Academic Search

This report presents an evaluation of the first transit-based smart parking project in the U.S. at the San Francisco Bay Area Rapid Transit (BART) District station in Oakland, California. The report begins with a review of the smart parking literature; next the smart parking field test is described including its capital, operational, and maintenance costs; then the results of the

Caroline J. Rodier; Susan A. Shaheen; Charlene Kemmerer

2008-01-01

413

Smart Parking Management Pilot Project: A Bay Area Rapid Transit (BART) District Parking Demonstration  

E-print Network

smart parking management contractor, ParkingCarma TM worked with California Partners for Advanced Transit and Highways (AND HIGHWAYS CALIFORNIA PATH PROGRAM INSTITUTE OF TRANSPORTATION STUDIES UNIVERSITY OF CALIFORNIA, BERKELEY SMARTSmart Park proposal for the Santa Clara Valley Transit Authority (VTA) along Highway

Shaheen, Susan; Rodier, Caroline J.; Eaken, Amanda M.

2005-01-01

414

Smart Parking Management Field Test: A Bay Area Rapid Transit (BART) District Parking Demonstration  

E-print Network

smart parking management contractor, ParkingCarma TM worked with California Partners for Advanced Transit and Highways (Smart Park proposal for the Santa Clara Valley Transit Authority (VTA) along Highwayon Highway 24 and decide to take BART en-route. The smart

Shaheen, Susan

2005-01-01

415

CrowdPark: A Crowdsourcing-based Parking Reservation System for Mobile Phones  

E-print Network

}@cs.umass.edu§ , {baik.hoh, ken.tracton, toch.iwuchukwu, juong-sik.lee}@nokia.com ABSTRACT Parking in crowded urban areas time. 1. INTRODUCTION Parking in crowded urban areas is a precious resource and drivers spend York City, in particular, have a pressing problem due to limited parking in downtown areas, both

Shenoy, Prashant

416

Development of Models for Park Rangers' Perceived Isolation of National Park Service Areas  

Microsoft Academic Search

Asurvey of U.S. National Park Service (NPS) rangers examined perceived isolation, personality, and organizational variables. Park areas in a variety of isolated and nonisolated settings were sampled. Statistical indices in this study address issues of isolation previously noted as important in NPS areas. Indices relating to park distance from small urban areas reflect substantial elements of perceived isolation ratings. Models

Barrett Caldwell

1990-01-01

417

The parks PDA: a handheld device for theme park guests in squeak  

Microsoft Academic Search

The Parks PDA is a lightweight, handheld device for theme park guests that functions as a combination guidebook, map, and digital camera. Together with a small team of artists and designers, we created a prototype Parks PDA and content for a three hour guest experience, including a camera interface, a hyper-linked guide book, three games, an animal spotters guide, a

Yoshiki Ohshima; John Maloney; Andy Ogden

2003-01-01

418

National Park Service: The Condition of Lodging Facilities Varies among Selected Parks.  

National Technical Information Service (NTIS)

The National Park Service offers visitors to our national parks a variety of overnight lodging accommodations including deluxe, mid-scale, and economy rooms. In some cases, these are the only lodging facilities located in or near a park. Concessioners man...

1998-01-01

419

Water Resources Management Plan: Arches National Park & Canyonlands National Park, Utah  

Microsoft Academic Search

The National Park Service recognizes the importance of preserving, conserving, and protecting water resources within its boundaries. Water resources, whether as large as the Colorado River or as small as a seep in Ernie's Country of Canyonlands National Park, play a distinctive role in linking ecosystems and , in general, provide habitat for a number of organisms. To protect park

Lynn Cudlip; Kevin Berghoff; David Vana-Miller

1999-01-01

420

Inhibition of IL-12 production by thalidomide.  

PubMed

The immunomodulatory properties of thalidomide are currently being exploited therapeutically in conditions as diverse as erythema nodosum leprosum, chronic graft-vs-host disease, rheumatoid arthritis, and sarcoidosis. The relevant mechanism of action of thalidomide in these diseases remains unclear. The important role recently ascribed to IL-12, a cytokine critical to the development of cellular immune responses, in the pathogenesis of several of these conditions led us to examine whether thalidomide affects the production of IL-12. Thalidomide potently suppressed the production of IL-12 from human PBMC and primary human monocytes in a concentration-dependent manner. Thalidomide-induced inhibition of IL-12 production was additive to that induced by suboptimal inhibiting doses of dexamethasone, and occurred by a mechanism independent of known endogenous inhibitors of IL-12 production. These results suggest that thalidomide may have therapeutic utility in a wide range of immunologic disorders that are characterized by inappropriate cellular immune responses. PMID:9366446

Moller, D R; Wysocka, M; Greenlee, B M; Ma, X; Wahl, L; Flockhart, D A; Trinchieri, G; Karp, C L

1997-11-15

421

University of Aberdeen Car Parking Policy -v2.0.docx University of Aberdeen Car Parking Policy  

E-print Network

in an available space in designated staff parking areas. A permit or voucher does not guarantee a car parking to search for and park in an available priority or standard space in designated staff parking areas. A permit entitles students to search for and park in an available space in designated areas matching

Levi, Ran

422

SmartParking: A Secure and Intelligent Parking System Using NOTICE Gongjun Yan, Stephan Olariu, Michele C. Weigle, Mahmoud Abuelela  

E-print Network

SmartParking: A Secure and Intelligent Parking System Using NOTICE Gongjun Yan, Stephan Olariu, Michele C. Weigle, Mahmoud Abuelela Abstract-- Parking is costly and limited in almost every major city, called SmartParking, is a service- oriented intelligent parking system through which drivers can view

Weigle, Michele

423

Amphibians of Olympic National Park  

USGS Publications Warehouse

Amphibians evolved from fishes about 360 million years ago and were the first vertebrates adapted to life on land. The word amphibian means "double life." It refers to the life history of many amphibians, which spend part of their life in water and part on land. There are three major groups of amphibians: salamanders, frogs, and toads, and caecilians. Salamanders, frogs, and toads can be found in Olympic National Park (ONP), but caecilians live only in tropical regions. Many amphibians are generalist predators, eating almost any prey they can fit into their mouths.

2000-01-01

424

Jurassic Park Institute: Dino Lab  

NSDL National Science Digital Library

Created as a "science-based and educationally focused program," the Jurassic Park Institute (JPI) aims to provide "kids, families, educators and scientists with the ultimate resource for dinosaur learning and fun." As would be expected from a project of Universal Studios, the JPI Dino Lab Web site is packed with cool computer animation and other multimedia features. Visitors to this site become virtual dinosaur paleontologists, interpreting discoveries and solving problems along the way. Educators can register for JPI Dino Lab's free Teacher Resources, which includes lesson plans, assessment tools, and teaching strategy tips. This site is best accessed with a high-speed connection.

425

IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival.  

PubMed

Natural killer T (NKT) cells are innate-like T cells that rapidly recognize pathogens and produce cytokines that shape the ensuing immune response. IL-17-producing NKT cells are enriched in barrier tissues, such as the lung, skin, and peripheral lymph nodes, and the factors that maintain this population in the periphery have not been elucidated. Here we show that NKT17 cells deviate from other NKT cells in their survival requirements. In contrast to conventional NKT cells that are maintained by IL-15, ROR?t(+) NKT cells are IL-15 independent and instead rely completely on IL-7. IL-7 initiates a T-cell receptor-independent (TCR-independent) expansion of NKT17 cells, thus supporting their homeostasis. Without IL-7, survival is dramatically impaired, yet residual cells remain lineage committed with no downregulation of ROR?t evident. Their preferential response to IL-7 does not reflect enhanced signaling through STAT proteins, but instead is modulated via the PI3K/AKT/mTOR signaling pathway. The ability to compete for IL-7 is dependent on high-density IL-7 receptor expression, which would promote uptake of low levels of IL-7 produced in the non-lymphoid sites of lung and skin. This dependence on IL-7 is also reported for ROR?t(+) innate lymphoid cells and CD4(+) Th17 cells, and suggests common survival requirements for functionally similar cells. PMID:24448098

Webster, K E; Kim, H-O; Kyparissoudis, K; Corpuz, T M; Pinget, G V; Uldrich, A P; Brink, R; Belz, G T; Cho, J-H; Godfrey, D I; Sprent, J

2014-09-01

426

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies  

PubMed Central

The inflammasome is a cytoplasmic multiprotein complex that promotes proinflammatory cytokine maturation in response to host- and pathogen-derived signals. Missense mutations in cryopyrin (NLRP3) result in a hyperactive inflammasome that drives overproduction of the proinflammatory cytokines IL-1? and IL-18, leading to the cryopyrin-associated periodic syndromes (CAPS) disease spectrum. Mouse lines harboring CAPS-associated mutations in Nlrp3 have elevated levels of IL-1? and IL-18 and closely mimic human disease. To examine the role of inflammasome-driven IL-18 in murine CAPS, we bred Nlrp3 mutations onto an Il18r-null background. Deletion of Il18r resulted in partial phenotypic rescue that abolished skin and visceral disease in young mice and normalized serum cytokines to a greater extent than breeding to Il1r-null mice. Significant systemic inflammation developed in aging Nlrp3 mutant Il18r-null mice, indicating that IL-1 and IL-18 drive pathology at different stages of the disease process. Ongoing inflammation in double-cytokine knockout CAPS mice implicated a role for caspase-1–mediated pyroptosis and confirmed that CAPS is inflammasome dependent. Our results have important implications for patients with CAPS and residual disease, emphasizing the need to explore other NLRP3-mediated pathways and the potential for inflammasome-targeted therapy. PMID:24084736

Brydges, Susannah D.; Broderick, Lori; McGeough, Matthew D.; Pena, Carla A.; Mueller, James L.; Hoffman, Hal M.

2013-01-01

427

IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease.  

PubMed

Interleukin-2 (IL-2) and IL-15 are structurally related cytokines that share receptor components but display markedly different effects in multiple in vivo model systems. Here we demonstrate that IL-15 but not IL-2 exacerbates xenogeneic graft-versus-host disease (X-GVHD) in severe combined immunodeficient murine recipients of human peripheral-blood lymphocytes (hu-PBL-SCID). Treatment of hu-PBL-SCID mice with IL-15 resulted in rapid fatality, lymphocytic infiltrations in the liver, lung, and spleen consistent with X-GVHD, and a marked expansion of human CD4+ and CD8+ T cells compared with controls. Depletion of human T cells in vivo abrogated the lethality of IL-15 treatment. To our knowledge, these data are the first to demonstrate in vivo activation and expansion of human T lymphocytes in response to IL-15 with concomitant exacerbation of human T-cell-mediated X-GVHD. PMID:15976176

Roychowdhury, Sameek; Blaser, Bradley W; Freud, Aharon G; Katz, Kerry; Bhatt, Darshna; Ferketich, Amy K; Bergdall, Valerie; Kusewitt, Donna; Baiocchi, Robert A; Caligiuri, Michael A

2005-10-01

428

IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease  

PubMed Central

Interleukin-2 (IL-2) and IL-15 are structurally related cytokines that share receptor components but display markedly different effects in multiple in vivo model systems. Here we demonstrate that IL-15 but not IL-2 exacerbates xenogeneic graft-versus-host disease (X-GVHD) in severe combined immunodeficient murine recipients of human peripheral-blood lymphocytes (hu-PBL-SCID). Treatment of hu-PBL-SCID mice with IL-15 resulted in rapid fatality, lymphocytic infiltrations in the liver, lung, and spleen consistent with X-GVHD, and a marked expansion of human CD4+ and CD8+ T cells compared with controls. Depletion of human T cells in vivo abrogated the lethality of IL-15 treatment. To our knowledge, these data are the first to demonstrate in vivo activation and expansion of human T lymphocytes in response to IL-15 with concomitant exacerbation of human T-cell-mediated X-GVHD. (Blood. 2005;106:2433-2435) PMID:15976176

Roychowdhury, Sameek; Blaser, Bradley W.; Freud, Aharon G.; Katz, Kerry; Bhatt, Darshna; Ferketich, Amy K.; Bergdall, Valerie; Kusewitt, Donna; Baiocchi, Robert A.; Caligiuri, Michael A.

2005-01-01

429

Discovery Park Impact International Breast Cancer & Nutrition (IBCN) Project  

E-print Network

Discovery Park Impact International Breast Cancer & Nutrition (IBCN) Project NEED The development assistance with proposals, budgets, communication tools, and many details. RESOLUTION Discovery Park provides with other Purdue expertise. IMPACTS Discovery Park is the infrastructure supporting the creation of several

Holland, Jeffrey

430

36 CFR 7.54 - Theodore Roosevelt National Park.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false Theodore Roosevelt National Park. 7.54 Section 7.54 ...Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR...SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.54 Theodore...

2010-07-01

431

36 CFR 7.11 - Saguaro National Park.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false Saguaro National Park. 7.11 Section 7.11 ...Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR...SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.11 Saguaro...

2010-07-01

432

36 CFR 14.10 - Areas of National Park System.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false Areas of National Park System. 14.10 Section 14...Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR...Interest § 14.10 Areas of National Park System. (a) The...

2010-07-01

433

36 CFR 7.47 - Carlsbad Caverns National Park.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false Carlsbad Caverns National Park. 7.47 Section 7.47 ...Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR...SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.47 Carlsbad...

2010-07-01

434

36 CFR 7.39 - Mesa Verde National Park.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false Mesa Verde National Park. 7.39 Section 7.39 ...Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR...SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.39 Mesa...

2010-07-01

435

32 CFR 855.16 - Parking and storage.  

Code of Federal Regulations, 2011 CFR

...Landing Permits § 855.16 Parking and storage. The...purpose of use authorized. Parking and storage may be permitted...are Air Force aero clubs, parking and storage privileges may be permitted in the area designated for aero...

2011-07-01

436

32 CFR 855.16 - Parking and storage.  

Code of Federal Regulations, 2010 CFR

...Landing Permits § 855.16 Parking and storage. The...purpose of use authorized. Parking and storage may be permitted...are Air Force aero clubs, parking and storage privileges may be permitted in the area designated for aero...

2010-07-01

437

32 CFR 855.16 - Parking and storage.  

Code of Federal Regulations, 2012 CFR

...Landing Permits § 855.16 Parking and storage. The...purpose of use authorized. Parking and storage may be permitted...are Air Force aero clubs, parking and storage privileges may be permitted in the area designated for aero...

2012-07-01

438

32 CFR 636.30 - Stopping, standing and parking.  

...by signs, as a “No Parking” area. (8) Along a roadway...is authorized in housing areas unless otherwise posted. (11) Parking is prohibited upon lawns...occupancy in the quarters area. Parking of recreational...

2014-07-01

439

32 CFR 636.30 - Stopping, standing and parking.  

Code of Federal Regulations, 2013 CFR

...by signs, as a “No Parking” area. (8) Along a roadway...is authorized in housing areas unless otherwise posted. (11) Parking is prohibited upon lawns...occupancy in the quarters area. Parking of recreational...

2013-07-01

440

32 CFR 855.16 - Parking and storage.  

Code of Federal Regulations, 2013 CFR

...Landing Permits § 855.16 Parking and storage. The...purpose of use authorized. Parking and storage may be permitted...are Air Force aero clubs, parking and storage privileges may be permitted in the area designated for aero...

2013-07-01

441

32 CFR 855.16 - Parking and storage.  

...Landing Permits § 855.16 Parking and storage. The...purpose of use authorized. Parking and storage may be permitted...are Air Force aero clubs, parking and storage privileges may be permitted in the area designated for aero...

2014-07-01

442

76 FR 70483 - Gettysburg National Military Park Advisory Commission  

Federal Register 2010, 2011, 2012, 2013

...Service [4400-SZM] Gettysburg National Military Park Advisory Commission AGENCY: National...September 6, 2012 of the Gettysburg National Military Park Advisory Commission. DATES: The...Education Center in the Gettysburg National Military Park Museum and Visitor Center,...

2011-11-14

443

76 FR 77552 - Gettysburg National Military Park Advisory Commission  

Federal Register 2010, 2011, 2012, 2013

...Service [4400-SZM] Gettysburg National Military Park Advisory Commission AGENCY: National...September 6, 2012 of the Gettysburg National Military Park Advisory Commission. DATES: The...Education Center in the Gettysburg National Military Park Museum and Visitor Center,...

2011-12-13

444

FACING NORTH ALONG CANDLER PARK DRIVE TOWARD NORTHWEST CORNER OF ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FACING NORTH ALONG CANDLER PARK DRIVE TOWARD NORTHWEST CORNER OF PARK - Candler Park Historic District, Roughly bounded by Moreland, Dekalb, McLendon & Harold Avenues, Matthews Street & Clifton Terrace, Atlanta, Fulton County, GA

445

FACING NORTH ALONG CANDLER PARK DRIVE (WESTERN BOUNDARY OF CANDLER ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FACING NORTH ALONG CANDLER PARK DRIVE (WESTERN BOUNDARY OF CANDLER PARK IS RIGHT SIDE OF ROAD IN PHOTOGRAPH) - Candler Park Historic District, Roughly bounded by Moreland, Dekalb, McLendon & Harold Avenues, Matthews Street & Clifton Terrace, Atlanta, Fulton County, GA

446

40 CFR 247.14 - Park and recreation products.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 2010-07-01 false Park and recreation products. 247.14 ...MATERIALS Item Designations § 247.14 Park and recreation products. (a) Playground...construction or other applications. (c) Park benches and picnic tables containing...

2010-07-01

447

Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10.  

PubMed

Exogenously added IL-10 rapidly inhibited Staphylococcus aureus- or LPS-induced cytokine mRNA expression in human PBMCs and monocytes, with a maximal effect observed when IL-10 was added from 20 h before until 1 h after the addition of the inducers. Nuclear run-on assays revealed that the inhibition of IL-12 p40, IL-12 p35, and TNF-alpha was at the gene transcriptional level and that the addition of IL-10 to S. aureus- or LPS-treated PBMCs did not affect mRNA stability. The inhibitory activity of IL-10 was abrogated by cycloheximide (CHX), suggesting the involvement of a newly synthesized protein(s). The addition of CHX at 2 h before S. aureus or LPS also inhibited the accumulation of IL-12 p40 mRNA, but did not inhibit IL-12 p35 and TNF-alpha mRNA. This finding suggests that p40 transcription is regulated through a de novo synthesized protein factor(s), whereas the addition of CHX at 2 h after S. aureus activation caused superinduction of the IL-12 p40, IL-12 p35, and TNF-alpha genes. These results indicate that in human monocytes, the mechanism(s) of IL-10 suppression of both IL-12 p40 and IL-12 p35 genes is primarily seen at the transcriptional level, and that the induction of the IL-12 p40 and p35 genes have different requirements for de novo protein synthesis. PMID:9637507

Aste-Amezaga, M; Ma, X; Sartori, A; Trinchieri, G

1998-06-15

448

Expression and function of IL-12 and IL-18 receptors on human tonsillar B cells.  

PubMed

IL-12 activates murine and human B cells, but little information is available as to the expression and function of IL-12R on human B lymphocytes. Here we show that the latter cells, freshly isolated from human tonsils, expressed the transcripts of both beta1 and beta2 chains of IL-12R and that beta2 chain mRNA was selectively increased (4- to 5-fold) by incubation with Staphylococcus aureus Cowan I bacteria or IL-12. B cell stimulation with IL-12 induced de novo expression of the transcripts of the two chains of IL-18R, i.e., IL-1 receptor-related protein and accessory protein-like. Functional studies showed that both IL-12 and IL-18 signaled to B cells through the NF-kappaB pathway. In the case of IL-12, no involvement of STAT transcription factors, and in particular of STAT-4, was detected. c-rel and p50 were identified as the members of NF-kappaB family involved in IL-12-mediated signal transduction to B cells. IL-12 and IL-18 synergized in the induction of IFN-gamma production by tonsillar B cells, but not in the stimulation of B cell differentiation, although either cytokine promoted IgM secretion in culture supernatants. Finally, naive but not germinal center or memory, tonsillar B cells were identified as the exclusive IL-12 targets in terms of induction of NF-kappaB activation and of IFN-gamma production. PMID:11120812

Airoldi, I; Gri, G; Marshall, J D; Corcione, A; Facchetti, P; Guglielmino, R; Trinchieri, G; Pistoia, V

2000-12-15

449

Scrivere il Medioevo. Lo spazio, il cibo, la santit. Un libro dedicato ad Odile Redon, Roma, Viella, 2001. Laurence MOULINIER  

E-print Network

Scrivere il Medioevo. Lo spazio, il cibo, la santità. Un libro dedicato ad Odile Redon, Roma auteur, publié dans "Scrivere il Medio evo. Lo spazio, la santità, il cibo. Un libro dedicato ad Odile spazio, il cibo, la santità. Un libro dedicato ad Odile Redon, Roma, Viella, 2001. 2 membres du clergé

Paris-Sud XI, Université de

450

Quick Guide to VT Parking & Transportation Procedures for FOR THE COMPLETE PARKING RULES AND REGULATIONS, REFER TO OUR WEBSITE AT WWW.PARKING.VT.EDU  

E-print Network

, and resident parking areas. Parking is not allowed in areas restricted by signs, such as service vehicle areas, carpool spaces, TA spaces, visitor spaces, and admission guest areas. RESIDENT STUDENT PARKING Resident are $35. Expired meter tickets are $30. Parking in a fire lane, bus lane, or air intake area is a $65

Buehrer, R. Michael

451

Marital Adjustment and Interleukin-6 (IL-6)  

PubMed Central

Building on prior research that marital functioning is associated with a variety of health outcomes, we evaluated the association between marital adjustment and a marker of inflammation in a sample of married adults between the ages of 35 and 84 years old (N = 415) from the second wave of the population-based Survey of Midlife Development in the United States (MIDUS II). Specifically, we evaluated associations between positive (i.e., partner support) and negative (i.e., partner strain) dimensions of marital adjustment and interleukin-6 (IL-6) separately for men and women, and whether these associations were moderated by age. Results indicated that (a) marital adjustment was not associated with IL-6 in men, (b) age moderated the association between marital adjustment and IL-6 in women, (c) partner support and partner strain were associated with IL-6 in younger women, and (d) partner support but not partner strain was uniquely associated with IL-6 in younger women. The associations between marital adjustment and IL-6 in younger women were significant when controlling for demographic variables, health status indicators, health behaviors, depressive symptoms, and perceived stress. These findings suggest that IL-6 may be a useful biomarker for studying health-relevant biological responses within intimate relationships, and that young women, in particular, may exhibit increased inflammation when partner support is low. PMID:22229879

Whisman, Mark A.; Sbarra, David A.

2014-01-01

452

Parking and Traffic regulaTions  

E-print Network

. Anthony Milneburg Road 19 26 1a 3030 29a 29b RESEARCH & TECHNOLOGY PARK 37 C A B D Leon C. Simon Blvd. Children's Center 11. Computer Center 12. Earl K. Long Library 13. Engineering Bldg. 14. Facility Services research & technology park 35. Advanced Technology Center 36. Center for Energy Research Management 37

Kulp, Mark

453

PARKING MANAGEMENT STRATEGIES FOR REDUCING AUTOMOBILE EMISSIONS  

EPA Science Inventory

This report defines the concept of parking management and explores how parking management can be used to improve air quality, support mass transit, reduce energy consumption and improve the amenities of life in urban areas. Specific aspects of this analysis were developments of a...

454

Burning cars in a parking Jean Bertoin  

E-print Network

separating two forests turns occupied, and disappear when hit by a lightning. The evolution of the system: Knuth parking scheme, forest fire, phase transition. 1 Introduction The purpose of this work is to point in statistical physics and computer science, namely forest fires and parking schemes. Its motivation partly stems

455

Burning cars in parkings Jean Bertoin  

E-print Network

separating two forests turns occupied, and disappear when hit by a lightning. The evolution of the system: Knuth parking scheme, forest fire, phase transition. 1 Introduction The purpose of this work is to point in statistical physics and computer science, namely forest fires and parking schemes. Its motivation partly stems

456

PARKING COMMISSION MINUTES March 5, 2013  

E-print Network

, but many people will get only one ticket and not pay it. We are also using a new system, ROVR, from our the focus from connecting tickets to students to getting letters sent out immediately upon identification on the Park & Ride route. There was also discussion about how changes to Park & Ride might fit

457

Design of Parking Lots and Garages.  

ERIC Educational Resources Information Center

Layout, control, and sign posting in the design of parking facilities is discussed emphasizing self parking and automated control. Considerations such as site, traffic, function of the facility, city codes, and sizes are related to design considerations. Traffic control factors are related to the direction and placement of cars and the collection…

McConochie, William R.

458

Transportation and Parking Committee Meeting Minutes  

E-print Network

Transportation and Parking Committee Meeting Minutes May 14, 2008 AFC Room 201 This meeting was held in conjunction with the Safety and Security Committee. Attendees of the Transportation: · reviewing cross over issues between the Safety and Security Committee and the Transportation and Parking

Acton, Scott

459

WIND DATA REPORT Deer Island Parking Lot  

E-print Network

WIND DATA REPORT Deer Island Parking Lot May 1, 2003 ­ July 15, 2003 Prepared for Massachusetts. Ellis Taylor Geer January 15, 2004 Renewable Energy Research Laboratory University of Massachusetts........................................................................................................................ 16 TABLE OF FIGURES Figure 1 - Site location at Deer Island Parking Lot site................

Massachusetts at Amherst, University of

460

Mysore-Park 14 Jan 2010  

E-print Network

mathematical model of real-world system formal specification of quantitative system properties exhaustive expected value running precise mathematical model of real-world system system+ #12;Mysore-Park 14 Jan 2010Mysore-Park 14 Jan 2010 R. Calinescu Introduction Quantitative verification Multi-objective utility

Rajamani, Sriram K.

461

Taking parking protection to the next level.  

PubMed

Because of neighborhood crime problems, the Johns Hopkins Medical Institutions decided to undertake security improvement projects aimed at enhancing security/safety at the campus. This article focuses on the security changes and improvements to the parking structures and surface parking lots that have helped make the campus a safer place for patients, visitors, and staff. PMID:11951392

Coppola, Joseph R; Cohen, Larry J; Economas, George

2002-01-01

462

The Evolving Urban Mobile-Home Park.  

ERIC Educational Resources Information Center

Examines the urban mobile-home park in the context of its evolution over the past 25 years. It was during this time period that the joint roles of mobile-homes and mobile-home parks in the provision of housing began to be recognized. (RM)

Foster, Richard H. Jr.

1981-01-01

463

Yellowstone National Park Region Seismicity Maps  

NSDL National Science Digital Library

This University of Utah website provides numerous maps of the Yellowstone National Park area that show the location and magnitude of historical earthquakes. Time intervals include the previous day, week, 30-days, 90-days, year, 1973 to present, 1973-1981, and 1983 to present. The maps also include latitude and longitude, park boundary, and fault information.

Stations, University O.

464

Nez Perce National Historical Park: Additions Study.  

National Technical Information Service (NTIS)

The study examines 16 sites located in Idaho, Oregon, Washington and Montana as possible additions to Nez Perce National Historical Park. The majority of the sites are associated with the 1877 Nez Perce War. Recommendations are made to enhance the parks' ...

1988-01-01

465

The Arrest Records of Rosa Parks.  

ERIC Educational Resources Information Center

Provides background information on the arrest of Rosa Parks and the effects this event had on the Civil Rights Movement. Offers a collection of teaching activities in which the students examine the arrest records of Rosa Parks and explains that these activities are designed to accompany a unit on racial segregation. (CMK)

Bredhoff, Stacey; Schamel, Wynell; Potter, Lee Ann

1999-01-01

466

PARKING COMMISSION MINUTES November 29, 2012  

E-print Network

include a move to assigned parking and/or market-based pricing. Transit Kaiser said that there is not much Drive. There was discussion about how these decisions are made, and also about athletic event parking. There was additional discussion about cash flow issues at Athletics, and the possibility of asset management

467

15 CFR 265.16 - Parking.  

Code of Federal Regulations, 2012 CFR

...do so by a uniformed guard; (j) Except in an area specifically designated for parking or standing; (k) Except within a single space...for such purposes, when parking or standing in an area with marked spaces; (l) At any place in...

2012-01-01

468

15 CFR 265.16 - Parking.  

Code of Federal Regulations, 2013 CFR

...do so by a uniformed guard; (j) Except in an area specifically designated for parking or standing; (k) Except within a single space...for such purposes, when parking or standing in an area with marked spaces; (l) At any place in...

2013-01-01

469

32 CFR 263.10 - Parking.  

Code of Federal Regulations, 2013 CFR

...so by a uniformed guard. (10) Except in an area specifically designated for parking or standing. (11) Except within a single space...for such purposes, when parking or standing in an area with marked spaces. (12) At any place in...

2013-07-01

470

32 CFR 263.10 - Parking.  

Code of Federal Regulations, 2011 CFR

...so by a uniformed guard. (10) Except in an area specifically designated for parking or standing. (11) Except within a single space...for such purposes, when parking or standing in an area with marked spaces. (12) At any place in...

2011-07-01

471

15 CFR 265.16 - Parking.  

Code of Federal Regulations, 2011 CFR

...do so by a uniformed guard; (j) Except in an area specifically designated for parking or standing; (k) Except within a single space...for such purposes, when parking or standing in an area with marked spaces; (l) At any place in...

2011-01-01

472

32 CFR 263.10 - Parking.  

Code of Federal Regulations, 2010 CFR

...so by a uniformed guard. (10) Except in an area specifically designated for parking or standing. (11) Except within a single space...for such purposes, when parking or standing in an area with marked spaces. (12) At any place in...

2010-07-01

473

32 CFR 263.10 - Parking.  

Code of Federal Regulations, 2012 CFR

...so by a uniformed guard. (10) Except in an area specifically designated for parking or standing. (11) Except within a single space...for such purposes, when parking or standing in an area with marked spaces. (12) At any place in...

2012-07-01

474

15 CFR 265.16 - Parking.  

Code of Federal Regulations, 2010 CFR

...do so by a uniformed guard; (j) Except in an area specifically designated for parking or standing; (k) Except within a single space...for such purposes, when parking or standing in an area with marked spaces; (l) At any place in...

2010-01-01

475

15 CFR 265.16 - Parking.  

...do so by a uniformed guard; (j) Except in an area specifically designated for parking or standing; (k) Except within a single space...for such purposes, when parking or standing in an area with marked spaces; (l) At any place in...

2014-01-01

476

The Practicing Librarian: Public Library Parking Needs.  

ERIC Educational Resources Information Center

Suggests standards for the numbers of parking spaces needed for a public library. From the annual Library Journal public library construction questionnaires, data were available on the number of parking spaces and the square foot size of the buildings reported; information on estimated needs was collected from the librarians in charge of each…

Galvin, Hoyt

1978-01-01

477

University of Maryland College Park Physics Department  

E-print Network

University of Maryland­ College Park Physics Department Physics Summer Girls Program Application Mail to: Bernie Kozlowski 1120 Physics Building University of Maryland College Park, MD 20742 NAME why you are interested in the summer physics program at the University of Maryland. NO APPLICATION

Lathrop, Daniel P.

478

Traffic and Parking Services Financial Statements  

E-print Network

Traffic and Parking Services Financial Statements June 30, 2013 #12;FLORIDA ATLANTIC UNIVERSITY revenue increased 2.5%. Traffic fines, parking fees and meters revenue also contributed to the increase and liabilities - is one way to measure the financial health, or financial position of the Division. Over time

Fernandez, Eduardo

479

78 FR 51207 - Kobuk Valley National Park Subsistence Resource Commission (SRC) and the Denali National Park SRC...  

Federal Register 2010, 2011, 2012, 2013

...Commission (SRC) and the Denali National Park SRC; Meetings AGENCY: National...Commission (SRC) and the Denali National Park SRC will hold meetings to develop...gov/kova/contacts.htm. Denali National Park SRC Meeting Date and...

2013-08-20

480

75 FR 3488 - Acadia National Park; Bar Harbor, ME; Acadia National Park Advisory Commission; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF THE INTERIOR National Park Service Acadia National Park; Bar Harbor, ME; Acadia National Park Advisory Commission; Notice of Meeting Notice is hereby given in accordance with the Federal...

2010-01-21

481

Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice.  

PubMed

Neutrophil defects predispose to severe fungal infections, yet the immunomodulatory role of these cells is poorly defined. The contribution of neutrophils to the early cytokine balance governing Th1 and Th2 cell development was examined in mice with candidiasis. Neutrophils secreted IL-12 and IL-10, correlating with the respective development of self-limiting (Th1-associated) and progressive (Th2-associated) disease. Exogenous IL-12 was effective in protecting neutropenic hosts susceptible to infection. These results suggest that 1) neutrophils, via their ability to release cytokines, play an active role in determining the qualitative development of the T cell response, and 2) their early role in anticandidal immunity can be replaced by exogenous IL-12. PMID:9164955

Romani, L; Mencacci, A; Cenci, E; Spaccapelo, R; Del Sero, G; Nicoletti, I; Trinchieri, G; Bistoni, F; Puccetti, P

1997-06-01

482

National Park Service: Air Resources Division  

NSDL National Science Digital Library

This is the homepage of the National Park Service's Air Resources Division. Materials featured here address issues of visibility protection, air quality standards, and air pollution throughout the National Park System, the National Wildlife Refuge System, and Wilderness areas. Information on air quality trends for specific parks is also provided. Remote cameras allow for real-time webcasts of air quality in a selection of parks. Additional materials include law and policy information, monitoring data, and maps and GIS products. An educational page for students and teachers features posters, videos, lesson plans, games, and basic air quality information including raw monitoring data. A link is also provided to a list of publications including reports, factsheets, newsletters, videos, lesson plans, and interpretive products for park visitors.

483

Hypalgesia effect of IL-24, a quite new mechanism for IL-24 application in cancer treatment.  

PubMed

Tumor suppressor melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) has been extensively regarded as an anti-oncogene; however, that whether IL-24, as a member of IL-10 family, is involved in cancer pain was seldom reported before. In this study, we found that IL-24 mediated by adenovirus could significantly increase the plantar mechanical pain threshold in both operation side and contralateral side of the animal models, which were established by injecting 5×103 Walker 256 rat breast cancer ascitic tumor cells into rats' tibia bone medullary canals; IL-24 could also suppress in vitro Walker 256 cells growth by inducing cell apoptosis. Pathologically, IL-24 could protect bone trabecula and substantia corticalis ossium from being completely destructed. Enzyme-linked immunosorbent assay (ELISA) showed that IL-24 treatment could increase the ?-endorphin levels and decrease the IL-6 concentration in plasma of animals. Our study indicated that IL-24 has a potential treatment effect on cancers not only by inhibiting tumor proliferation, but also by the promotion of ?-endorphin synthesis, inhibition of IL-6 secretion to relieve cancer pain. PMID:23869901

Zhao, Yaodong; Tian, Li; Sheng, Weihua; Miao, Jingcheng; Yang, Jicheng

2013-10-01

484

Photodynamic therapy affects the expression of IL-6 and IL-10 in vivo  

NASA Astrophysics Data System (ADS)

Photodynamic therapy (PDT), which can effectively destroy malignant tissue, also induces a complex immune response which potentiates anti-tumor immunity, but also inhibits skin contact hypersensitivity (CHS) and prolongs skin graft survival. The underlying mechanisms responsible for these effects are poorly understood, but are likely to involve meditation by cytokines. We demonstrate in a BALB/c mouse model that PDT delivered to normal and tumor tissue in vivo causes marked changes in the expression of cytokines interleukin (IL)-6 and IL-10. IL-6 mRNA and protein are rapidly and strongly enhanced in the PDT treated EMT6 tumor. Previous studies have shown that intratumoral injection of IL- 6 or transduction of the IL-6 gene into tumor cells can enhance tumor immunogenicity and inhibit tumor growth in experimental murine tumor systems. Thus, PDT may enhance local anti-tumor immunity by up-regulating IL-6. PDT also results in an increase in IL-10 mRNA and protein in the skin. The same PDT regime which enhances IL-10 production in the skin has been shown to strongly inhibit the CHS response. The kinetics of IL-10 expression coincide with the known kinetics of PDT induced CHS suppression and we propose that the enhanced IL-10 expression plays a role in the observed suppression of cell mediated responses seen following PDT.

Gollnick, Sandra O.; Musser, David A.; Henderson, Barbara W.

1998-05-01

485

Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1?/IL-6 loop.  

PubMed

Proliferation and differentiation of keratinocytes are normally well balanced, but this balance can be perturbed in wound healing and is dysregulated in pathological conditions such as atopic dermatitis. Epithelial-mesenchymal interaction affects this event via the cross-talk of cytokines and growth factors. Periostin, a matricellular protein, has an important role during reepithelialization in wound healing and is critical for hyperproliferation of keratinocytes in atopic dermatitis. Here we investigated how periostin regulates proliferation and differentiation of keratinocytes in the epithelial-mesenchymal interactions using a three-dimensional organotypic air-liquid interface coculture system. The release of IL-1? from keratinocytes and subsequent IL-6 production from fibroblasts were critical for keratinocyte proliferation and differentiation. Periostin secreted from fibroblasts was required for IL-1?-induced IL-6 production and enhanced IL-6 production by activation of the NF-?B pathway synergistically with IL-1?. Thus, the combination of an autocrine loop of periostin and a paracrine loop composed of IL-1? and IL-6 regulates keratinocyte proliferation and differentiation in the epithelial-mesenchymal interactions, and periostin tunes the magnitude of keratinocyte proliferation and differentiation by interacting with the paracrine IL-1?/IL-6 loop. PMID:24352037

Taniguchi, Kazuto; Arima, Kazuhiko; Masuoka, Miho; Ohta, Shoichiro; Shiraishi, Hiroshi; Ontsuka, Kanako; Suzuki, Shoichi; Inamitsu, Masako; Yamamoto, Ken-ichi; Simmons, Olga; Toda, Shuji; Conway, Simon J; Hamasaki, Yuhei; Izuhara, Kenji

2014-05-01

486

Extramedullary Expansion of Hematopoietic Progenitor Cells in Interleukin (IL)-6-sIL-6R Double Transgenic Mice  

PubMed Central

Soluble cytokine receptors modulate the activity of their cognate ligands. Interleukin (IL)-6 in association with the soluble IL-6 receptor (sIL-6R) can activate cells expressing the gp130 signal transducer lacking the specific IL-6R. To investigate the function of the IL-6–sIL-6R complex in vivo and to discriminate the function of the IL-6–sIL-6R complex from the function of IL-6 alone, we have established a transgenic mouse model. Double-transgenic mice coexpressing IL-6 and sIL-6R were generated and compared with IL-6 and sIL-6R single-transgenic mice. The main phenotype found in IL-6–sIL-6R mice was a dramatic increase of extramedullary hematopoietic progenitor cells in liver and spleen but not in the bone marrow. In IL-6 single-transgenic mice and sIL-6R single-transgenic mice no such effects were observed. The high numbers of hematopoietic progenitor cells were reflected by a strong increase of peripheral blood cell numbers. Therefore, activators of the gp130 signal transducer like the IL-6–IL-6R complex may represent most powerful stimulators for extramedullary hematopoietic progenitor cells. gp130 activators may become important for the expansion of hematopoietic progenitor cells in vivo and in vitro. PMID:9034153

Peters, Malte; Schirmacher, Peter; Goldschmitt, Jutta; Odenthal, Margarete; Peschel, Christian; Fattori, Elena; Ciliberto, Gennaro; Dienes, Hans-Peter; Buschenfelde, Karl-Hermann Meyer zum; Rose-John, Stefan

1997-01-01

487

IL23 Is Increased in Dendritic Cells in Multiple Sclerosis and Down-Regulation of IL23 by Antisense Oligos Increases Dendritic Cell IL10 Production  

Microsoft Academic Search

IL-23 is a heterodimeric cytokine comprising a p19 subunit associated with the IL-12\\/23p40 subunit. Like IL-12, IL-23 is expressed predominantly by activated dendritic cells (DCs) and phagocytic cells, and both cytokines induce IFN- secretion by T cells. The induction of experimental autoimmune encephalitis, the animal model of multiple sclerosis (MS), occurs in mice lacking IL-12, but not in mice with

Adi Vaknin-Dembinsky; Konstantin Balashov; Howard L. Weiner

488

Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra.  

PubMed

Following traumatic brain injury (TBI), cascades of inflammatory processes occur. Laboratory studies implicate the cytokines interleukin-1alpha (IL-1alpha) and IL-1beta in the pathophysiology of TBI and cerebral ischemia, whilst exogenous and endogenous interleukin-1 receptor antagonist (IL-1ra) is neuroprotective. We analyzed IL-1alpha, IL-1beta, and IL-1ra in brain microdialysates (100-kDa membrane) in 15 TBI patients. We also analyzed energy-related molecules (glucose, lactate, pyruvate, glutamate, and the lactate/pyruvate ratio) in these brain microdialysates. Mean of mean (+/-SD) in vitro microdialysis percentage recoveries (extraction efficiencies) were IL-1alpha 19.7+/-7.6%, IL-1beta 23.9+/-10.5%, and IL-1ra 20.9+/-6.3%. In the patients' brain microdialysates, mean of mean cytokine concentrations (not corrected for percentage recovery) were IL-1alpha 5.6+/-14.8 pg/mL, IL-1beta 10.4+/-14.7 pg/mL, and IL-1ra 2796+/-2918 pg/mL. IL-1ra was consistently much higher than IL-1alpha and IL-1beta. There were no significant relationships between IL-1 family cytokines and energy-related molecules. There was a significant correlation between increasing IL-1beta and increasing IL-1ra (Spearman r=0.59, p=0.028). There was also a significant relationship between increasing IL-1ra and decreasing intracranial pressure (Spearman r=-0.57, p=0.041). High concentrations of IL-1ra, and also high IL-1ra/IL-1beta ratio, were associated with better outcome (Mann Whitney, p=0.018 and p=0.0201, respectively), within these 15 patients. It is unclear whether these IL-1ra concentrations are sufficient to antagonize the effects of IL-1beta in vivo. This study demonstrates feasibility of our microdialysis methodology in recovering IL-1 family cytokines for assessing their inter-relationships in the injured human brain, and suggests a neuroprotective role for IL-1ra. It remains to be seen whether exogenous IL-1ra or other agents can be used to manipulate cytokine levels in the brain, for potential therapeutic effect. PMID:17970618

Hutchinson, Peter J; O'Connell, Mark T; Rothwell, Nancy J; Hopkins, Stephen J; Nortje, Jürgens; Carpenter, Keri L H; Timofeev, Ivan; Al-Rawi, Pippa G; Menon, David K; Pickard, John D

2007-10-01

489

IL-7 and TSLP receptors: twisted sisters.  

PubMed

In this issue of Blood, Shochat et al report mutations in receptors for interleukin-7 (IL-7) and thymic stromal lymphopoietin (TSLP), resulting in a novel dimerization mechanism that drives acute lymphoblastic leukemias. PMID:24993875

Durum, Scott K

2014-07-01

490

Understanding the mechanism of IL-1? secretion  

PubMed Central

The cytokine interleukin-1? (IL-1?) is a key mediator of the inflammatory response. Essential for the host-response and resistance to pathogens, it also exacerbates damage during chronic disease and acute tissue injury. It is not surprising therefore that there is a huge level of interest in how this protein is produced and exported from cells. However, the mechanism of IL-1? release has proven to be elusive. It does not follow the conventional ER-Golgi route of secretion. A literature full of disparate observations arising from numerous experimental systems, has contributed to a complicated mix of diverse proposals. Here we summarise these observations and propose that secretion of IL-1? occurs on a continuum, dependent upon stimulus strength and the extracellular IL-1? requirement. PMID:22019906

Lopez-Castejon, Gloria; Brough, David

2011-01-01

491

Cutting edge: the development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cells.  

PubMed

Although IL-4-producing B cells (B effector 2 cells) are found following infection and immunization, the signals regulating IL-4 production by Be2 cells are unknown. We show that culturing naive B cells with Th2 cells induces up-regulation of IL-4 in the B cells with a concomitant down-regulation of T-bet, IL-12Rbeta2, and IFN-gamma. Up-regulation of IL-4 in the Be2 cells is dependent on both T cells and IL-4 as IL-4Ralpha-deficient B cells primed with Th2 cells did not transcribe IL-4, and B cells primed in the presence of IL-4-deficient Th2 cells produced IFN-gamma instead of IL-4. Likewise, the in vivo development of IL-4-expressing B cells in a nematode infection model was dependent on both T cells and IL-4Ralpha-mediated signals. Thus, the differentiation of naive B cells into IL-4-expressing Be2 cells is regulated by a combination of T cell-dependent signals and the cytokine environment and this process is critically dependent upon the IL-4/IL-4R signaling pathway. PMID:16301612

Harris, David P; Goodrich, Stephen; Mohrs, Katja; Mohrs, Markus; Lund, Frances E

2005-12-01

492

Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-gamma and IL-4 in human keratinocytes.  

PubMed

It is known that large amounts of histamine are stored in mast cells located in the superficial dermis of the skin and can be released upon appropriate stimulation. However, the effects of histamine on keratinocyte function have not been well characterized. We therefore examined the capacity of histamine to modulate the production of interleukin (IL)-6 and IL-8 by keratinocytes. We found that histamine significantly augmented the production of IL-6 and IL-8 in a dose- and time-dependent manner. The enhancing effects of histamine were completely inhibited by a potent H1 receptor (H1R) antagonist, emedastine difumarate. Pyrilamine (a much weaker H1R antagonist) and cimetidine (an H2R antagonist) only partially inhibited the enhancing effects of histamine. The histamine-induced up-regulation of IL-6 and IL-8 production, however, was completely abrogated by a combination of pyrilamine and cimetidine. The IL-6 production was significantly enhanced by interferon (IFN)-gamma. Interestingly, IFN-gamma and IL-4 both significantly augmented the histamine-induced IL-6 production. On the other hand, the production of IL-8 was inhibited by IFN-gamma, and IFN-gamma and IL-4 both completely abrogated the histamine-induced IL-8 production. These results suggest that the histamine-induced IL-6 production and IL-8 production are differentially regulated by IFN-gamma and IL-4. Histamine may be an important modulator of cytokine production in epidermal milieu. PMID:11916128

Kohda, Futoshi; Koga, Tetsuya; Uchi, Hiroshi; Urabe, Kazunori; Furue, Masutaka

2002-01-01

493

IL13, IL4R?, and Stat6 Are Required for the Expulsion of the Gastrointestinal Nematode Parasite Nippostrongylus brasiliensis  

Microsoft Academic Search

Although IL-4 induces expulsion of the gastrointestinal nematode parasite, Nippostrongylus brasiliensis, from immunodeficient mice, this parasite is expelled normally by IL-4-deficient mice. This apparent paradox is explained by observations that IL-4 receptor ? chain (IL-4R?)-deficient mice and Stat6-deficient mice fail to expel N. brasiliensis, and a specific antagonist for IL-13, another activator of Stat6 through IL-4R?, prevents worm expulsion. Thus,

Joseph F Urban Jr.; Nancy Noben-Trauth; Debra D Donaldson; Kathleen B Madden; Suzanne C Morris; Mary Collins; Fred D Finkelman

1998-01-01

494

Erri De Luca, il naplide Nicolas Bonnet  

E-print Network

Erri De Luca, il napòlide Nicolas Bonnet Professeur, Laboratoire Interlangues EA 4182, Université] @u-bourgogne.fr Erri De Luca considère, depuis les années de son adolescence, que le mot « patrie, Naples, et avec le dialecte napolitain, la langue « où » il est né ». Erri De Luca considera, fin dagli

Paris-Sud XI, Université de

495

IL-15/IL-15R?-mediated avidity maturation of memory CD8+ T cells  

PubMed Central

T cell avidity is critical to viral clearance, but mechanisms of CD8+ T cell avidity maturation are poorly understood. Here, we find that IL-15 mediates two mechanisms of avidity maturation. (i) By selection at the population level, IL-15 promotes greater survival of high- compared with low-avidity cytotoxic T lymphocytes (CTLs). High-avidity CTLs express higher levels of IL-15R? and persist longer by homeostatic proliferation. (ii) At the individual cell level, IL-15 induces higher levels of surface coreceptor CD8??, increasing functional avidity. IL-15 during priming selects or induces higher-avidity CTLs. Conversely, high-avidity CTLs are diminished in IL-15R? knockout mice. These results provide an explanation of CD8+ T cell avidity maturation and may contribute to the design of novel vaccines. PMID:15477598

Oh, SangKon; Perera, Liyanage P.; Burke, Donald S.; Waldmann, Thomas A.; Berzofsky, Jay A.

2004-01-01

496

Submerged cultivation of Ganoderma lucidum and the effects of its polysaccharides on the production of human cytokines TNF-?, IL-12, IFN-?, IL-2, IL-4, IL-10 and IL-17.  

PubMed

An original strain of Ganoderma lucidum (W.Curt.:Fr.) Lloyd, MZKI G97 isolated from Slovenian habitats was grown by a submerged liquid substrate cultivation in a laboratory stirred tank reactor. Five fractions of extracellular and cell-wall polysaccharides were obtained by extraction, ethanol precipitation, and purification by ion-exchange, gel and affinity chromatography. The capacity of isolated polysaccharide fractions to induce innate inflammatory cytokines, and to modulate cytokine responses of activated lymphocytes was investigated. Human peripheral blood mononuclear cells (PBMC) were activated in vitro with polysaccharide fractions, in order to induce innate inflammatory cytokines: tumor necrosis factor alpha (TNF-?), interleukin (IL) 12 and interferon gamma (IFN-?). For the immunomodulation capacity, polysaccharide fractions were cultured with ionomycine and phorbol myristate acetate (IONO+PMA) activated PBMC, and the concentrations of induced IL-2, IL-4, IFN-?, IL-10 and IL-17 were measured. The results showed that polysaccharides from G. lucidum induced moderate to high amounts of innate inflammatory cytokines. Fungal cell-wall polysaccharides were stronger innate inflammatory cytokines inducers, while extracellular polysaccharides demonstrated a higher capacity to modulate cytokine responses of IONO+PMA induced production of IL-17. The results indicate that G. lucidum polysaccharides enhance Th1 response with high levels of IFN-? and IL-2, and display low to no impact on IL-4 production. A similar pattern was observed at regulatory cytokine IL-10. All of the polysaccharide fractions tested induced IL-17 production at different concentration levels. PMID:25078944

Habijanic, Jožica; Berovic, Marin; Boh, Bojana; Plankl, Mojca; Wraber, Branka