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1

American Nuclear Society 2013 Student Conference Massachusetts Institute of Technology Boston, Massachusetts, USA, April 4-6, 2013, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2013)  

E-print Network

American Nuclear Society 2013 Student Conference ­ Massachusetts Institute of Technology Boston, Massachusetts, USA, April 4-6, 2013, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2013) A DETECTOR Conference ­ Massachusetts Institute of Technology Boston, Massachusetts, USA, April 4-6, 2013 2/4 Assuming

Danon, Yaron

2013-01-01

2

Sixth American Nuclear Society International Topical Meeting on Nuclear Plant Instrumentation, Control, and Human-Machine Interface Technologies NPIC&HMIT 2009, Knoxville, Tennessee, April 5-9, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL  

E-print Network

Sixth American Nuclear Society International Topical Meeting on Nuclear Plant Instrumentation, Control, and Human-Machine Interface Technologies NPIC&HMIT 2009, Knoxville, Tennessee, April 5-9, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009) FUELASSEMBLY SELF SHIELDING

Danon, Yaron

3

75 FR 3253 - Lamb Assembly and Test, LLC, Subsidiary of Mag Industrial Automation Systems, Machesney Park, IL...  

Federal Register 2010, 2011, 2012, 2013, 2014

...LLC, Subsidiary of Mag Industrial Automation Systems, Machesney Park, IL; Notice...based on the finding that imports of automation equipment and machine tools did not...The survey revealed no imports of automation equipment and machine tools by...

2010-01-20

4

Nebraska's Wetlands By Ted LaGrange,  

E-print Network

Nebraska's Wetlands By Ted LaGrange, Wetland Program Manager, Nebraska Game and Parks Commission Nebraska's wetland resources are as diverse and dynamic as those of any state in the nation. They include. Some wetlands hold water for only a few weeks or less during the spring while others never go

Nebraska-Lincoln, University of

5

Lagrange structure and quantization  

Microsoft Academic Search

A path-integral quantization method is proposed for dynamical systems whose classical equations of motion do not necessarily follow from the action principle. The key new notion behind this quantization scheme is the Lagrange structure which is more general than the lagrangian formalism in the same sense as Poisson geometry is more general than the symplectic one. The Lagrange structure is

Peter O. Kazinski; Simon L. Lyakhovich; Alexey A. Sharapov

2005-01-01

6

5. Wick, O. J. (ed.) Plutonium Handbook: a Guide to the Technology 3357 (American Nuclear Society, LaGrange Park, IL, 1980).  

E-print Network

5. Wick, O. J. (ed.) Plutonium Handbook: a Guide to the Technology 33­57 (American Nuclear Society superconductors. Phys. Rev. Lett. 8, 250­253 (1962). 11. Wolfer, W. G. Radiation effects in plutonium. Los Alamos

Dinsmore, Tony

7

CRAIG G. FRASER"' LAGRANGE'S ANALYTICAL MATHEMATICS,  

E-print Network

, by researchers throughout Europe. Among this group was Auguste Comte, the founder of positive philosophy, whoCRAIG G. FRASER"' LAGRANGE'S ANALYTICAL MATHEMATICS, ITS CARTESIAN ORIGINS AND RECEPTION IN COMTE M. Le Comte J.-L. Lagrange', in: Oeuvres de Lagrange, Vol. 1 (Paris: Gauthier-Villars, 1867). pp. ix

Fraser, Craig

8

Demonstration of Underwater Acoustic Sensor Networks System Jung-Il Namgung, Soo-Young Shin, Soo-Hyun Park  

E-print Network

1 ­ Deployed underwater sensor nodes in a water tank. The sensor nodes, which were shown in Figure 2 Table eless Network water sensor n Sensor board d sensor node k Connection nodes which is d e s #12;Demonstration of Underwater Acoustic Sensor Networks System Jung-Il Namgung, Soo-Young Shin, Soo

Zhou, Shengli

9

Langmuir Monolayers of Co Nanoparticles and Their Patterning by Microcontact Printing Jong-Il Park, Woo-Ram Lee, Sung-Soo Bae, Youn Joong Kim, Kyung-Hwa Yoo,  

E-print Network

Langmuir Monolayers of Co Nanoparticles and Their Patterning by Microcontact Printing Jong-Il Park the Langmuir- Blodgett (LB) method. Transmission electron microscopy (TEM) was used to show that, with increasing surface pressure, the Co nanoparticles become well-organized into a Langmuir monolayer

Kim, Sehun

10

Dark universe with Lagrange multipliers  

NASA Astrophysics Data System (ADS)

Cosmological models with Lagrange multipliers are appealing because they could explain the behaviour of the dark sector in a unified way, in this sense dark matter and dark energy are two limits of a single fluid which describes the late behaviour of our universe at large scales. In this work we analyze extensions to the "Dust of Dark Energy model" proposed in JCAP 1005,012(2010) by including spatial curvature and more general potentials of the scalar field. We perform a dynamical system study and we present bayesian statistical analysis for the model using supernovae type Ia and H(z) data.

Cid, Antonella; Labrana, Pedro

2015-03-01

11

International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)  

E-print Network

, and the ability of the charged particles resulting from neutron interaction in the absorption layer to escape and sub-micron structures, along with the ability to efficiently collect the electron-hole pairs created electron-hole pair collection, allowing for the fabrication of higher efficiency detectors then were

Danon, Yaron

12

Advances in Nuclear Fuel Management IV (ANFM 2009) Hilton Head Island, South Carolina, USA, April 12-15, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)  

E-print Network

- France merle@lpsc.in2p3.fr Keywords: Molten Salt Reactor, Thorium fuel cycle, fast neutron spectrum concept that we called the Thorium Molten Salt Reactor (TMSR), which is particularly well suited to fulfil "non-moderated Thorium Molten Salt Reactor" or TMSR-NM. With a fuel salt content low in light elements

Paris-Sud XI, Université de

13

Joint International Topical Meeting on Mathematics & Computation and Supercomputing in Nuclear Applications (M&C + SNA 2007) Monterey, California, April 15-19, 2007, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2007)  

E-print Network

for advanced burner reactors call for liquid sodium coolant passing through subassemblies of hexagonally the amount passing through the near-wall subchannels. Analysis of wire-wrapped fuel pins is challenging

Fischer, Paul F.

14

International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)  

E-print Network

operator such as EDF, the time required to compute nuclear reactor core simulations is rather critical. Introduction As operator of nuclear power plants, EDF needs many nuclear reactor core simulationsInternational Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009

Vialle, Stéphane

2009-01-01

15

Parks Research  

NSDL National Science Digital Library

Research your park and convince me it is the best one. Choose your park and find at least 7 GREAT facts !!! Denali National Park Grand Canyon National Park Great Smoky Mountains National Park Mount Rainier National Park Olympic National Park Rocky Mountain National Park Yellowstone National Park Yosemite National Park Zion National Park Zion National Park 2 ...

Mrs. Guy

2013-10-05

16

Mesh-Independence of Lagrange-SQP Methods with Lipschitz-Continuous Lagrange Multiplier Updates  

Microsoft Academic Search

An augmented Lagrange-SQP method with Lipschitz continuous Lagrange multiplier updates is analyzed. The approximation of this method is investigated, and convergence results are presented. A mesh-independence principle for the augmented Lagrange-SQP method is proved, which asserts that asymptotically the infinite-dimensional algorithm and finite-dimensional discretizations have the same convergence property. More precisely, for sufficiently small mesh-size there is at most a

S. Volkwein

2002-01-01

17

Pay Parking Permit Parking  

E-print Network

Buildings Parkings Pay Parking Permit Parking Information(student) Legend Information(security) Bus SCIENCES RECREATION &ATHLETICS BURNABY MOUN TAIN CONSE RVATION AREA Residence Lane Lot H P Rideshare

18

Three-dimensional, Free-Lagrange hydrodynamics  

SciTech Connect

This paper describes the algorithms that make up a 3-D version of the Free-Lagrange Method. The basic method involves the explicit integration of the fluid flow equations over control volumes formed by Voronoi cells. A Voronoi cell is an arbitrary, convex polyhedron that has plane polygon faces. The ''nearest'' neighbors of any given mass point are identified by noting the mass point that lies on the opposite side of a given Voronoi face. The nearest neighbors of a mass point are allowed to change in response to the (Lagrange) motion of the mass points. This implies that the mesh reorganizes itself as the mass points move with the fluid motion.

Trease, H.

1987-01-01

19

Analysis Of Lagrange Multiplier Based Domain Decomposition  

Microsoft Academic Search

The convergence of a substructuring iterative method with Lagrange multipliers known as Finite Element Tearing and Interconnecting (FETI) method is analyzed in this thesis. This method, originally proposed by Farhat and Roux, decomposes finite element discretization of an elliptic boundary value problem into Neumann problems on the subdomains, plus a coarse problem for the subdomain null space components. For linear

Radek Tezaur

1998-01-01

20

Three-dimensional Free-Lagrange hydrodynamics  

NASA Astrophysics Data System (ADS)

This paper presents a description of a three-dimensional Free-Lagrange code. The Free-Lagrange Method (FLM) is characterized by a global connectivity matrix that describes the "nearest" neighbor connections between the Lagrangian mass points. The nearest neighbor connectivity is dynamic with respect to time, so it must be constructed at time equal 0.0 and maintained thereafter. The code described in this paper explicitly integrates the 3-D fluid equations in time and space. Spatial derivatives are derived from area and volume weighted averages of quantities over the set of "nearest" neighbors for each point. The global connectivity matrix is maintained (and constructed) with a Voronoi mesh construction algorithm, where each pair of nearest neighbors are separated by a perpendicular bisecting plane. The spatial integration algorithm uses the Voronoi polyhedron as the integration control volume, but as discussed the median polyhedron will be used as the integration control volume in the future.

Trease, Harold E.

1988-01-01

21

Lagrange-mesh calculations in momentum space.  

PubMed

The Lagrange-mesh method is a powerful method to solve eigenequations written in configuration space. It is very easy to implement and very accurate. Using a Gauss quadrature rule, the method requires only the evaluation of the potential at some mesh points. The eigenfunctions are expanded in terms of regularized Lagrange functions which vanish at all mesh points except one. It is shown that this method can be adapted to solve eigenequations written in momentum space, keeping the convenience and the accuracy of the original technique. In particular, the kinetic operator is a diagonal matrix. Observables and wave functions in both configuration space and momentum space can also be easily computed with good accuracy using only eigenfunctions computed in the momentum space. The method is tested with Gaussian and Yukawa potentials, requiring, respectively, a small and a large mesh to reach convergence. Corresponding wave functions in both spaces are compared with each other using the Fourier transform. PMID:23005880

Lacroix, Gwendolyn; Semay, Claude; Buisseret, Fabien

2012-08-01

22

Car Park 31 Car Park 23  

E-print Network

Car Park 31 CarPark30 Car Park 1 Car Park 2 Car Park 23 Car Park 20 CarPark19 Car Park 29 Car Park 17 Car Park 16 Car Park 3 CarPark35 CarPark15 Car Park 14 Car Park 9 Car Park 33 CarPark6 CarPark5 Car Park 18 Car Park 10 Car Park 7 CaCa 8rkCCCCC PaPa kkCaCarrr P Car Park 8 Car Park 8 CarPark 21 Car

Tobar, Michael

23

Convergence of a substructuring methodwith Lagrange multipliers  

Microsoft Academic Search

Summary.  \\u000a We analyze the convergence of a substructuring iterative method\\u000a with Lagrange multipliers, proposed recently by Farhat and Roux.\\u000a The method decomposes finite element\\u000a discretization of an elliptic boundary value problem into\\u000a Neumann problems on the subdomains plus a coarse problem for the\\u000a subdomain nullspace components. For linear conforming elements and\\u000a preconditioning by the Dirichlet problems on the subdomains,\\u000a we

Jan Mandel; Radek Tezaur

1996-01-01

24

J. L. Lagrange's Early Contributions to the Principles and Methods  

E-print Network

of development whose origins extend back to LAGRANGE'S very early researches. Thus the basis of the Mdcanique in 1763 for a prize competition of the Paris Academy of Sciences. This memoir, devoted to the astronomical doing attempt to contribute to an understanding of the development of LAGRANGE'Sthought. My goals

Fraser, Craig

25

Multivariate Lagrange inversion formula and the cycle lemma  

E-print Network

of the multivariate Lagrange inver- sion formula that generalizes the celebrated proof of (Raney 1963 the alternative approach of (Joyal 1981) and (Labelle 1981) via labelled arborescences and endofunctions had been

Paris-Sud XI, Université de

26

Rayleigh-Lagrange formalism for classical dissipative systems.  

PubMed

It is often believed that the Rayleigh-Lagrange formalism for classical dissipative systems is unable to encompass forces described by nonlinear functions of the velocities. Here we show that this is indeed a misconception. PMID:25679729

Virga, Epifanio G

2015-01-01

27

Lagrange coordinates for the Einstein-Euler equations  

NASA Astrophysics Data System (ADS)

We derive a new symmetric hyperbolic formulation of the Einstein-Euler equations in Lagrange coordinates that are adapted to the Frauendiener-Walton formulation of the Euler equations. As an application, we use this system to show that the densitized lapse and zero-shift coordinate systems for the vacuum Einstein equations are equivalent to Lagrange coordinates for a fictitious fluid with a specific equation of state.

Oliynyk, Todd A.

2012-02-01

28

On the attraction of Newton's method to critical lagrange multipliers  

NASA Astrophysics Data System (ADS)

The attraction of dual trajectories of Newton's method for the Lagrange system to critical Lagrange multipliers is analyzed. This stable effect, which has been confirmed by numerical practice, leads to the Newton-Lagrange method losing its superlinear convergence when applied to problems with irregular constraints. At the same time, available theoretical results are of "negative" character; i.e., they show that convergence to a noncritical multiplier is not possible or unlikely. In the case of a purely quadratic problem with a single constraint, a "positive" result is proved for the first time demonstrating that the critical multipliers are attractors for the dual trajectories. Additionally, the influence exerted by the attraction to critical multipliers on the convergence rate of direct and dual trajectories is characterized.

Uskov, E. I.

2013-08-01

29

Contributed article A globally convergent Lagrange and barrier function iterative algorithm  

E-print Network

Contributed article A globally convergent Lagrange and barrier function iterative algorithm October 2000 Abstract In this paper a globally convergent Lagrange and barrier function iterative an entropy-type barrier function to deal with nonnegativity constraints and Lagrange multipliers to handle

Xu, Lei

30

TwilightTwilight phenomenaphenomena of Venusof Venus Laboratoire Lagrange  

E-print Network

°.5 Phase angle 177° Mallama et al. 2006 #12;Paolo Tanga ­The aureole of Venus Sakura/Europlanet WorkshopTwilightTwilight phenomenaphenomena of Venusof Venus P. Tanga Laboratoire Lagrange Observatoire de ­ Paris, March 6 2012 #12;Paolo Tanga ­The aureole of Venus Sakura/Europlanet Workshop ­ Paris, March 6

Widemann, Thomas

31

The Reduced Euler-Lagrange Equations Jerrold E. Marsden  

E-print Network

The Reduced Euler-Lagrange Equations Jerrold E. Marsden Department of Mathematics University(1993), 139­164. Abstract Marsden and Scheurle [1993] studied Lagrangian reduction in the context of momentum Introduction The goal of this paper is to study the reduction of Lagrangian systems with symme- tries. Marsden

Marsden, Jerrold

32

Barycentric coordinates for Lagrange interpolation over lattices on a simplex  

E-print Network

Barycentric coordinates for Lagrange interpolation over lattices on a simplex Gasper Jaklic (gasper.jaklic@fmf.uni-lj.si), Jernej Kozak (jernej.kozak@fmf.uni-lj.si), Marjeta Krajnc (marjetka.krajnc@fmf.uni-lj.si), Vito Vitrih (vito.vitrih@upr.si), Emil Zagar (emil.zagar@fmf.uni-lj.si) FMF and IMFM, University of Ljubljana

33

National Parks  

NSDL National Science Digital Library

This online directory focuses on national parks throughout the country that offer educational opportunities. Where possible, it includes the following information for each: the type of support offered, including educational materials, access to a naturalist or specialists, and classes/workshops; and mailing address and contact information. In addition, a link to the National Park Service's Web site is included.

34

Park It!  

ERIC Educational Resources Information Center

Many artists visit national parks to draw, paint and take photographs of some of the most amazing scenery on earth. Raw nature is one of the greatest inspirations to an artist, and artists can be credited for helping inspire the government to create the National Park System. This article features Thomas Moran (1837-1926), one of the artists who…

Sartorius, Tara Cady

2010-01-01

35

Central Park  

NSDL National Science Digital Library

As one of the worldâ??s greatest urban green spaces, Central Park is loved by dyed-in-the wool New Yorkers as well as visitors to the city. This reverential website provides detailed information about this fine public space and the activities that take place within its confines. On this site, visitors can look over maps of the park, learn about the parkâ??s many attractions, and browse a selection of photographs of this fine urban paradise. The homepage contains much of this material, along with a â??Central Park Newsâ?ť feature, which provides news updates about goings on throughout Central Park. For those planning a visit to the park, the Events area will be most useful, as it provides information about such pastimes as rock climbing, ice skating lessons, and yoga.

2006-01-01

36

Sixth American Nuclear Society International Topical Meeting on Nuclear Plant Instrumentation, Control, and Human-Machine Interface Technologies NPIC&HMIT 2009, Knoxville, Tennessee, April 5-9, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL  

E-print Network

, automation 1 INTRODUCTION In nuclear power plants (NPPs), novel digitalized I&C systems enable complicatedSixth American Nuclear Society International Topical Meeting on Nuclear Plant Instrumentation power plants, novel digitalized I&C systems have brought out new needs for safety evaluation

Heljanko, Keijo

37

Parks Canada  

NSDL National Science Digital Library

The national park system of Canada is extensive, stretching from Baffin Island to areas in British Columbia. The stated goal of the system is "to establish a system of national parks that represents each of Canada's distinct natural regions." First-time visitors to the site can use the Introduction area to learn more about the system, and there's also a Planning Your Visit link that's quite helpful. The basic document that most users will want to check out here is titled "National Parks System Plan" and it offers a broad overview of the 39 national parks in Canada. Visitors can learn about parks such as Aulavik, Prince Edward Island, and others by clicking over to the Find a National Park area. Naturalists and scientists can use the Species at Risk area to learn about what the Canadian government is doing to protect species such as the whooping crane and the seaside centipede lichen. Finally, the site is rounded out by the Managing Human Use link which talks about their long-range plans to ensure that the parks maintain a balance between visitors and conserving the natural areas.

2008-10-27

38

@central park  

NSDL National Science Digital Library

The Central Park Conservancy, a not-for-profit organization dedicated to restoring, improving, and managing Central Park's grounds and facilities, offers this "official" site, which contains a wealth of information about what is arguably the world's most famous city park. Each of the site's sections contains useful or interesting information; the Then & Now section, for instance, offers an overview of Central Park's history, a bibliography with 43 entries for those seeking further information, and a list of movies with scenes set in the park. Another highlight of the site is the Virtual Park, which consists of a set of clickable maps through which users can explore 72 points of interest, each described in the affectionate style of a travel guidebook. The site's other sections include such features as events schedules, press releases, information on when and where particular varieties of flowers bloom, and a section devoted entirely to activities for families and children. This site will be especially useful to those who are planning a visit to Central Park, but other users will likely find it informative and entertaining as well.

39

75 FR 52013 - Notice of Intent to Repatriate Cultural Items: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013, 2014

...Cultural Items: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History (Field Museum), Chicago, IL, that...OR, for the Field Museum of Natural History. The items were accessioned into...

2010-08-24

40

The unexplained accuracy of the Lagrange-mesh method.  

PubMed

The Lagrange-mesh method is an approximate variational calculation which resembles a mesh calculation because of the use of a Gauss quadrature. In order to analyze its accuracy, four different Lagrange-mesh calculations based on the zeros of Laguerre polynomials are compared with exact variational calculations based on the corresponding Laguerre basis. The comparison is performed for three solvable radial potentials: the Morse, harmonic-oscillator, and Coulomb potentials. The results show that the accuracies of the energies obtained for different partial waves with the different mesh approximations are very close to the variational accuracy, even in the presence of the centrifugal singularity. The same property holds for the approximate wave functions. This striking accuracy remains unexplained. PMID:11863688

Baye, D; Hesse, M; Vincke, M

2002-02-01

41

Park Shorelines  

NSDL National Science Digital Library

This webpage of the National Park Service (NPS) and United States Geological Survey (USGS) discusses the environments of coastlines - the narrow strips of land where national parks meet the sea. It covers the formation of waves and beaches, as well as how beaches move through longshore drift. Also included are plans for paper models of island coral reefs, which include shield volcanoes, fringing reefs, barrier reefs, and atolls.

42

ACCESSIBILITY ACCESSIBLE PARKING  

E-print Network

O ACCESSIBILITY ELEVATOR ACCESSIBLE PARKING ACCESSIBLE ENTRY CURB CUT PARKING GARAGE PARKING GARAGE........................ 45 Communications Museum ........................... 22 Computer Science.................................................... 80 Development................................................ 12 Dining Services

Gera, Ralucca

43

Alaska Park Science National Park Service  

E-print Network

Alaska Park Science National Park Service Alaska Support Office 2525 Gambell Street Anchorage, Alaska 99503-2892 PhotographcourtesyofAlutiiqMuseumandHeritageCenter NationalParkServicephotograph #12;Alaska Park Science Connections to Natural and Cultural Resource Studies in Alaska's National Parks

44

Car Parking and Access Car Parking  

E-print Network

Car Parking and Access Car Parking Parking permits are provided free of charge for visitors of the car parks on campus for the duration of the conference. The number of available spaces, and the location, will depend on demand for car parking for University business on any given date. Unfortunately

Sussex, University of

45

Park Search  

NSDL National Science Digital Library

Its never too early to begin planning your summer vacation, especially in the depths of winter; those with cabin fever can get a jump on their outdoor recreation plans at this site, provided by L.L. Bean. Users can search this database of over 1,400 state and national parks, forests, and wildlife refuges by state, region, and/or activities in which they are interested (including winter sports for all-season recreators). Search returns include contact information, an overview of the park/ forest and its highlights, photos, and a list of approved or available activities.

46

Free Parking David Tarboton  

E-print Network

. GREEN permit holders may park in any Green or Yellow parking area. STUDENT ATHLETIC FACILITY TERRACE ENG STL STL STANLAUBPRACTICE FACILITY 1 2 2 BBT 3 3 4 Student Parking Areas BLUE permit holders may area. Misc. Parking Areas PUBLIC PAY PARKING Rates are posted at each site. STATE VEHICLE PARKING 1

Tarboton, David

47

Lagrange-Dirac systems for charged particles in gauge fields  

E-print Network

In this work, we use the Sternberg phase space (which may be considered as the classical phase space of particles in gauge fields) in order to explore the dynamics of such particles in the context of Lagrange-Dirac systems and their associated Hamilton-Pontryagin variational principles. For this, we develop an analogue of the Pontryagin bundle in the case of the Sternberg phase space. Moreover, we show the link of this new bundle to the so-called magnetized Tulczyjew triple, which is an analogue of the link between the Pontryagin bundle and the usual Tulczyjew triple. Taking advantage of the symplectic nature of the Sternberg space, we induce a Dirac structure on the Sternberg-Pontryagin bundle which leads to the Lagrange-Dirac structure that we are looking for. We also analyze the intrinsic and variational nature of the equations of motion of particles in gauge fields in regards of the defined new geometry. Lastly, we illustrate our theory through the case of a $U(1)$ gauge group, leading to the paradigmatic example of a electricaly charged particle in an electromagnetic field.

Fernando Jimenez

2014-10-13

48

The Control of the CE-02 satellite flying to the Lagrange Point  

NASA Astrophysics Data System (ADS)

The Control Strategy and process of the satellite of CE-02 flying to the Lagrange Point are introduced in this article, as well as the flight control and the payload experiment circling Lagrange Point are mentioned. There are four targets which controlling CE-02 flying to Lagrange Point. Firstly, making controlling the satellite to going farther distance in space into realization; Secondly, validating the method and capability of remote surveying and controlling after the two remote space surveying stations, Kashi and Kiamusze, are set up; thirdly, putting up scientific research of electriferous particles around the earth nearly the Lagrange Point; fourthly, observing the possible erupting of X and ? radial. the flight control flying to Lagrange Point was divided into three phases: Moon escape, transferring flight and circling Lagrange Point. After 4 orbit controlling to CE-02, the satellite entered into the Lissajous orbit apartting from the earth about 1.7 million kilometres on September 1st 2011. up to now, one orbit controlling in all was carrying through after the CE-02 satellite circling Lagrange Point in order to keep the satellite circling Lagrange Point. In this period, space circumstance detector collect large numbers of space circumstance dates, and the correlative scientific research have developing step by step.

Guo, J.; Liu, J.

2012-09-01

49

Necessary and Su cient Conditions for Mean Convergence of Lagrange Interpolation For  

E-print Network

Necessary and Su cient Conditions for Mean Convergence of Lagrange Interpolation For Erd}os weights of Lagrange Interpolation at the zeros of orthogonal polynomials pn(W2;x) for Erd}os Weights W2 = exp 2Q; it is necessary and su cient that > 1 p. This is, essentially, an ex- tension of the Erd}os{Turan theorem on Lp

Damelin, Steven

50

A Mortar Finite Element Method Using Dual Spaces For The Lagrange Multiplier  

Microsoft Academic Search

The mortar finite element method allows the coupling of different discretization schemes and triangulations across subregion boundaries. In the original mortar approach the matching at the interface is realized by enforcing an orthogonality relation between the jump and a modified trace space which serves as a space of Lagrange multipliers. In this paper, this Lagrange multiplier space is replaced by

Barbara I. Wohlmuth

1998-01-01

51

Theodore Roosevelt National Park  

NSDL National Science Digital Library

This National Park Service website contains information on: the park history; park activities such as hiking and camping; and natural history such as the wildlife, geology and paleontology of the park. The kids' section contains coloring pages, a park trivia quiz, reference sections on the wildlife and natural history of the park, and information on Theodore Roosevelt and his involvement in the Badlands. There are also images of the wildlife and scenery of the park.

52

Prospect Park  

NSDL National Science Digital Library

While many readers may be aware that trees grow in Brooklyn, few may be cognizant of the fact that, yes, a forest grows in Brooklyn. This urban forest just happens to be in the boroughâ??s own lovely Prospect Park, designed by those giants of landscape architects, Frederick Law Olmsted and Calvert Vaux. Often overlooked by some who are primarily concerned with that other large swath of green in the middle of Manhattan, Prospect Park contains a 90-acre meadow, a zoo, a celebrated performing arts festival, and a lake. Visitors to the Prospect Park Alliance website can learn all about these things, and also delve into the parkâ??s history. Those planning a visit may wish to look at the â??General Infoâ?ť and â??Places To Goâ?ť sections for a selection of brief descriptions and photographs. For those seeking a historical perspective the â??History & Natureâ?ť area is delightful. Here visitors can learn about the parkâ??s historical development and creation, and learn more about those individuals responsible for the parkâ??s design and aesthetic appeal. Finally, visitors should look at the online exhibit â??A Glimpse Of Prospect Parkâ?ť for a bit of visual perspective on the parkâ??s history.

Prospect Park (New York, N.Y.)

53

Interferometric Characterization of the Earth's Atmosphere from Lagrange Point 2  

NASA Technical Reports Server (NTRS)

Part of the NASA plans for future Earth-Science missions calls for observations using novel vantage points that can produce science products otherwise unobtainable. Observations of the Earth from the Lagrange-2 point, L-2, (1.5 million kilometers behind the Earth on the Earth-Sun line) affords a unique vantage point for atmospheric science. Special observation of the Earth's atmosphere using solar occultation techniques in the near infrared (1 to 4 microns) provides one of the most accurate method of passively sensing altitude profiles of the major species (CO2, O3, O2, CH4, H2O, N2O). In addition to observation of the Earth's atmosphere, it will be possible to observe a portion of the solar disk at moderate spatial resolution without interference from the Earth.

Herman, J. R.; Einaudi, Franco (Technical Monitor)

2001-01-01

54

LAGRANGE: LAser GRavitational-wave ANtenna in GEodetic Orbit  

NASA Astrophysics Data System (ADS)

We describe a new space gravitational wave observatory design called LAG-RANGE that maintains all important LISA science at about half the cost and with reduced technical risk. It consists of three drag-free spacecraft in a geocentric formation. Fixed antennas allow continuous contact with the Earth, solving the problem of communications bandwidth and latency. A 70 mm diameter sphere with a 35 mm gap to its enclosure serves as the single inertial reference per spacecraft, operating in “true” drag-free mode (no test mass forcing). Other advantages are: a simple caging design based on the DISCOS 1972 drag-free mission, an all optical read-out with pm fine and nm coarse sensors, and the extensive technology heritage from the Honeywell gyroscopes, and the DISCOS and Gravity Probe B drag-free sensors. An Interferometric Measurement System, designed with reflective optics and a highly stabilized frequency standard, performs the ranging between test masses and requires a single optical bench with one laser per spacecraft. Two 20 cm diameter telescopes per spacecraft, each with infield pointing, incorporate novel technology developed for advanced optical systems by Lockheed Martin, who also designed the spacecraft based on a multi-flight proven bus structure. Additional technological advancements include updated drag-free propulsion, thermal control, charge management systems, and materials. LAGRANGE subsystems are designed to be scalable and modular, making them interchangeable with those of LISA or other gravitational science missions. We plan to space qualify critical technologies on small and nano satellite flights, with the first launch (UV-LED Sat) in 2013.

Buchman, S.; Conklin, J. W.; Balakrishnan, K.; Aguero, V.; Alfauwaz, A.; Aljadaan, A.; Almajed, M.; Altwaijry, H.; Saud, T. A.; Byer, R. L.; Bower, K.; Costello, B.; Cutler, G. D.; DeBra, D. B.; Faied, D. M.; Foster, C.; Genova, A. L.; Hanson, J.; Hooper, K.; Hultgren, E.; Klavins, A.; Lantz, B.; Lipa, J. A.; Palmer, A.; Plante, B.; Sanchez, H. S.; Saraf, S.; Schaechter, D.; Shu, K.; Smith, E.; Tenerelli, D.; Vanbezooijen, R.; Vasudevan, G.; Williams, S. D.; Worden, S. P.; Zhou, J.; Zoellner, A.

2013-01-01

55

Park It!  

NSDL National Science Digital Library

The difference between an architect and an engineer is sometimes confusing because their roles in building design can be similar. Students experience a bit of both professions by following a set of requirements and meeting given constraints as they create a model parking garage. They experience the engineering design process first-hand as they design, build and test their models. They draw a blueprint for their design, select the construction materials and budget their expenditures. They also test their structures for strength and find their maximum loads.

Integrated Teaching and Learning Program and Laboratory,

56

National Environmental Research Parks  

SciTech Connect

The National Environmental Research Parks are outdoor laboratories that provide opportunities for environmental studies on protected lands that act as buffers around Department of Energy (DOE) facilities. The research parks are used to evaluate the environmental consequences of energy use and development as well as the strategies to mitigate these effects. They are also used to demonstrate possible environmental and land-use options. The seven parks are: Fermilab National Environmental Research Park; Hanford National Environmental Research Park; Idaho National Environmental Research Park; Los Alamos National Environmental Research Park; Nevada National Environmental Research Park; Oak Ridge National Environmental Research Park; and Savannah River National Environmental Research Park. This document gives an overview of the events that led to the creation of the research parks. Its main purpose is to summarize key points about each park, including ecological research, geological characteristics, facilities, and available databases.

Not Available

1994-07-01

57

What Did We Think Could Be Learned About Earth From Lagrange Point Observations?  

NASA Astrophysics Data System (ADS)

The scientific excitement surrounding the NASA Lagrange point mission Triana, now called DSCOVR, tended to be forgotten in the brouhaha over other aspects of the mission. Yet a small band of scientists in 1998 got very excited about the possibilities offered by the Lagrange-point perspective on our planet. As one of the original co-investigators on the Triana mission, I witnessed that scientific excitement firsthand. I will bring to life the early period, circa 1998 to 2000, and share the reasons that we thought the Lagrange-point perspective on Earth would be scientifically revolutionary.

Wiscombe, W. J.

2011-12-01

58

What Did We Think Could Be Learned About Earth From Lagrange Point Observations?  

NASA Technical Reports Server (NTRS)

The scientific excitement surrounding the NASA Lagrange point mission Triana, now called DSCOVR, tended to be forgotten in the brouhaha over other aspects of the mission. Yet a small band of scientists in 1998 got very excited about the possibilities offered by the Lagrange-point perspective on our planet. As one of the original co-investigators on the Triana mission, I witnessed that scientific excitement firsthand. I will bring to life the early period, circa 1998 to 2000, and share the reasons that we thought the Lagrange-point perspective on Earth would be scientifically revolutionary.

Wiscombe, Warren

2011-01-01

59

Violations & Enforcement Parking Violation Definitions  

E-print Network

Vehicles parked on a grade should have the emergency brake set. Keys should never be left in the ignition - · Improper parking and failure to park within lines Improper parking includes parking compact vehicles

Hong, Jason I.

60

IL13 EFFECTOR FUNCTIONS  

Microsoft Academic Search

? Abstract IL-13 was first recognized for its effects on B cells and monocytes, where it upregulated class II expression, promoted IgE class switching and inhibited inflammatory cytokine production. It was also thought to be functionally redundant with IL-4. However, studies conducted with knockout mice, neutralizing antibodies, and novel antagonists demonstrate that IL-13 possesses several unique effector func- tions that

Thomas A. Wynn

2003-01-01

61

Interferometric Characterization of the Earth's Atmosphere from Lagrange Point 2  

NASA Technical Reports Server (NTRS)

Part of the NASA plans for future Earth Science missions calls for observations using novel vantage points that can produce science products otherwise unobtainable. Observations of the Earth from the Lagrange-2 point, L-2, (1.5 million km behind the Earth on the Earth-Sun line) affords a unique vantage point for atmospheric science. Spectral observation of the Earth's atmosphere using solar occultation techniques in the near infrared (1 to 4 microns) provides one of the most accurate methods of passively sensing attitude profiles of the major species (CO2, O3, O2, CH4, H2O N2O). While traditional polar orbiting occultation measurements can obtain about 14 measurements per day (2 per orbit), solar occultation observations from the Lagrange-2 point will yield hourly profile measurements at all latitudes. The expected spatial resolution is 2 km in altitude, 0.5 degrees in latitude, and 2 degrees in longitude. The result from 24 hours of observations will be a three-dimensional map of atmospheric composition. To accomplish this task from L-2 requires the development of a large moderate spectral resolution instrument whose entrance aperture is about 10 meters. Use of a standard telescope design with a 10-meter circular mirror or a 10-meter strip mirror would be prohibitively expensive and excessively massive. Instead, we are proposing the development of a 10-meter linear interferometer coupled to a Fourier transform imaging spectrometer. The result will be a highly efficient design with sufficient sensitivity, while having both spatial and spectral resolution to produce the desired results. Preliminary calculations show that seven species (CO2, O3, O2, CH4, H2O N2O) have clearly separated spectral features in the I to 4 microns range with sufficient absorption to produce profile information from near the Earth's surface to the middle stratosphere. For CO2 the estimated sensitivity to change is 0.33% or 1 part in 330. This should be sufficient to detect changes that are significant for the carbon cycle studies. Initial instrument design studies are underway to determine the optimum optical design for the interferometer-spectrometer as well as the necessary highly stable mechanical designs. Separate design studies are being conducted for the spacecraft. shuttle launch facility, low-light solar power design, thermal control, and unique navigation requirements to reach and maintain the tight halo orbit about L-2.

Herman, Jay R.; Komar, George (Technical Monitor)

2001-01-01

62

IL-36 receptor antagonist with special emphasis on IL-38.  

PubMed

IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NFkB pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects. PMID:23527706

Shaik, Y; Sabatino, G; Maccauro, G; Varvara, G; Murmura, G; Saggini, A; Rosati, M; Conti, F; Cianchetti, E; Caraffa, A; Antinolfi, P; Pandolfi, F; Potalivo, G; Galzio, R; Conti, P; Theoharides, T C

2013-01-01

63

Conformal Traceless Decomposition of Lagrange Multiplier Modified Horava-Lifshitz Gravity  

E-print Network

We introduce conformal traceless decomposition in Lagrange Multiplier modified RFDiff invariant Horava-Lifshitz gravity. We perform Hamiltonian analysis of given action and determine the action for the physical degrees of freedom.

Kluson, J

2015-01-01

64

J. L. Lagrange's ChangingApproach to the Foundations of the Calculus of Variations  

E-print Network

LAGRANGE'S,whose views inevitably reflect those of the eminent practitioner looking back at his own place distinct periods: the first begins with his ear- liest letters to EULER in the mid-1750's and ends

Fraser, Craig

65

Conformal Traceless Decomposition of Lagrange Multiplier Modified Horava-Lifshitz Gravity  

E-print Network

We introduce conformal traceless decomposition in Lagrange Multiplier modified RFDiff invariant Horava-Lifshitz gravity. We perform Hamiltonian analysis of given action and determine the action for the physical degrees of freedom.

J. Kluson

2015-02-06

66

Centrifuge Rotor Models: A Comparison of the Euler-Lagrange and the Bond Graph Modeling Approach  

NASA Technical Reports Server (NTRS)

A viewgraph presentation on centrifuge rotor models with a comparison using Euler-Lagrange and bond graph methods is shown. The topics include: 1) Objectives; 2) MOdeling Approach Comparisons; 3) Model Structures; and 4) Application.

Granda, Jose J.; Ramakrishnan, Jayant; Nguyen, Louis H.

2006-01-01

67

Assessment of Interleukins IL-4, IL-6, IL-8, IL-10 in Acute Urticaria  

PubMed Central

Background Urticaria is a skin disease that affects approximately 5% of the general population and manifests itself, not only as an acute but also as a chronic disease. The etiology of the disease varies as well as its clinical manifestations which extend from the presence of urticarial hives to the potentially mortal angioedema. There is a great interest to the disease not only due to its special clinical manifestation but also due to its pathogenetic mechanism. New data in the medical bibliography support the participation of interleukins (ILs) in the pathophysiology of urticaria. The aim of the study is to contribute in the comprehension of possible participation of certain ILs in the pathogenesis of acute urticaria. Methods Our study concerns four ILs, IL-4, IL-6, IL-8 and IL-10, simultaneously and their quantitative changes during the acute phase of urticaria as well as 2 weeks after drug administration. Moreover, ILs levels of patients were compared with those of matched healthy controls. All measurements have been done by the ELISA method. The statistical analysis was done by SPSS. Results The results present increased levels (in 51 patients vs. 22 matched healthy controls) of all four ILs during the acute phase. Especially for IL-4 this increase was statistically very significant (P < 0.001). Statistically marginally significant decrease was also observed for IL-10 concentrations (P < 0.059), for the two blood samples (acute phase and 2 weeks later). Conclusion It is suggested by the present study that certain ILs might play an important role in the pathogenetic mechanism of urticaria. IL-4 and IL-10 participation seems to be relatively more significant. Possibly, ILs, liberated by mast cells, induce an influx of leukocytes in the dermis, therefore participating in the development of acute urticaria inflammation. PMID:24578755

Papadopoulos, Jordan; Karpouzis, Anthony; Tentes, John; Kouskoukis, Constantin

2014-01-01

68

Intelligent parking systems  

Microsoft Academic Search

The basic concepts of the parking reservation system and parking revenue management system are discussed in this paper. The proposed “intelligent” parking space inventory control system that is based on a combination of fuzzy logic and integer programming techniques makes “on line” decisions whether to accept or reject a new driver’s request for parking. In the first step of the

Dusan Teodorovic; Panta Lucic

2006-01-01

69

National Park Service Careers.  

ERIC Educational Resources Information Center

This booklet offers information on the employment needs of and career opportunities in the National Park Service. General information on the Service and employment is followed by specific information on these career opportunities: park ranger, park aide and technician, park police, administrative careers, and maintenance, trade, and craft…

National Park Service (Dept. of Interior), Washington, DC.

70

Grand Teton National Park  

NSDL National Science Digital Library

This National Park Service website provides a trip planner, information on natural and cultural history, publications, a park fact sheet for students, park maps, student bibliography, and a newspaper for kids. There is information on the geology, rock formations, mountain building, volcanism, and glaciation of the Teton Range. Educational resources for students and teachers consist of links to other National Park Service sites.

71

Relation between the Lagrange-Sylvester polynomial and functions of a square matrix  

E-print Network

RELATION BETWEEN THE LAGRANGE-SYLVESTER POLYNOMIAL AND FUNCTIONS OF A SQUARE MATRIX A Thesis By WILLIAM SAMUEL POWELL Submitted to the Graduate College of the Texas A&M University in partial fulfillment of the requrrements for the degree... of MASTER OF SCIENCE May 1968 Major Subject: Mathematics RELATION BETWEEN THE LAGRANGE-SYL'vESTER POLyNOMIAL AND FUNCTIONS OF A SQUARE MATRIX A Thesis By WILLIAM SAMUEL POWELL Approved as to style and content by: (Chairman of Committee) (Head...

Powell, William Samuel

1968-01-01

72

75 FR 45659 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013, 2014

...Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History, Chicago, IL. The human remains and...was made by the Field Museum of Natural History professional staff in consultation...

2010-08-03

73

75 FR 52022 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013, 2014

...Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History, Chicago, IL. The human remains and...remains was made by Field Museum of Natural History professional staff in consultation...

2010-08-24

74

75 FR 435 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013, 2014

...Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History, Chicago, IL. The human remains were...remains was made by Field Museum of Natural History professional staff in consultation...

2010-01-05

75

75 FR 438 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013, 2014

...Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History, Chicago, IL. The human remains were...remains was made by Field Museum of Natural History professional staff in consultation...

2010-01-05

76

Wind Cave National Park  

NSDL National Science Digital Library

This National Park Service website contains environmental education units for elementary and middle school students which consist of activities centered around an environmental theme. These themes include biodiversity, habitats, natural adaptation, patterns and order in nature, environmental cycles and change, interactions and interdependence within an ecosystem, and water in the environment. There is also information on: planning a visit to the park; the wildlife, geology, cave exploration and paleontology of the park; the park history; and the role of fire in the park.

77

Glacier National Park  

NSDL National Science Digital Library

This is the homepage of Glacier National Park. Users can access materials on the park's ecology and environment (plants and animals, biodiversity and air quality, geology, and fires), the culture and history of the park, park activities, and publications on naturalist activities. There are also video clips of park wildlife and scenery, a photo gallery, and live webcams. Links are provided to additional information, such as research activities on bear DNA and global climate change.

78

A new Remesh-Lagrange technique for advecting temperature that minimizes numerical diffusion  

NASA Astrophysics Data System (ADS)

The proper treatment of heat-advection is a generally underappreciated problem within CFD, yet particularly critical for calculating physically sound erosion in plume-lithosphere interactions and temperature sensitive melting processes. Typically, Eulerian (fixed-mesh) codes have been preferred to solve for fluid flow and they are almost essential for finite-difference-based algorithms. Unfortunately, the Eulerian approach introduces numerical artifacts into the solution of the advection-diffusion heat transport problem that can only be suppressed by adding 'too-diffusive' artificial diffusion to the equations, as for example in the Smolarkiewicz formulation for heat advection. We have developed a 'Remesh-Lagrange' method using a partly deforming finite element mesh and find it to be significantly more accurate than our previous methods. In several test scenarios we show the large improvement in accuracy that can be obtained by using a Lagrangian approach for 10-30 time steps (depending upon the distortion of the finite elements in the deformed Lagrangian mesh) and then regridding to the initial mesh. When an element becomes too distorted the nodes connected to it become fixed and we switch from Lagrange to a Semi-Lagrange formulation for these nodes. Instead of the standard 'linear backward' Semi-Lagrange we are also experimenting with a more accurate interpolation scheme for an unstructured mesh that additionally includes the nodal derivatives of the temperature field when calculating the value at the Semi-Lagrange traceback point. The same bicubic interpolation method for an unstructured grid is used to remesh the 'too-distorted' Lagrange grid back to the initial undistorted mesh. We compare the Remesh-Lagrange technique against the following Eulerian methods in a series of 2-D numerical experiments advecting stripes and Gaussian peaks in steady circulating flow: linear back-interpolation Semi-Lagrange method; bicubic back-interpolation Semi-Lagrange method; SUPG; and the Smolarkiewicz (flux- limiting diffusion) method, which is arguably the 'best-in-practice' of the Eulerian finite-difference methods. We also compare these methods for a test-case of diapiric upwelling that is forced by a pure chemical (non-diffusive) buoyancy associated with tracer particles that are advected by the plume upwelling. In this case, we find that the Eulerian methods typically underpredict the temperature of the plume head by about 20C, while overheating a ~50km region outside the plume-stem by about 10C in comparison to the Remesh-Lagrange technique.

Hasenclever, J.; Phipps Morgan, J.; Shi, C.

2007-12-01

79

National Park Service: Tour of Park Geology  

NSDL National Science Digital Library

The tour of Park geologic resources includes pages specific to individual National Parks, Monuments, Recreation Areas, Preserves, Seacoasts, Reserves, and Recreation Areas. These pages are indexed by park name, state, or by one of the following topics: basin and range, caves, Colorado Plateau, fossils, glaciers, hot springs, human use, mountain building, oldest rocks, plate tectonics, river systems, sand dunes, shoreline geology, or volcanoes. Organization of each of the pages typically follows a NPS template with categories for park geology, maps, photographs, geologic research, related links, visitor information, multimedia, and "teacher features" (educational resources and links for teaching geology with National Park examples.) Common subjects that are addressed at various park sites include: minerals, rocks, fossils, cave and karst systems, coastlines, glaciers, volcanoes, faults, landforms, landslides, structures, fluvial systems, sediments, soils, stratigraphic relations, processes that form or act on geologic features and their chemical compositions, and the history of the planet and its life forms.

80

Park Geology: Tour of National Parks  

NSDL National Science Digital Library

A great site from the National Park Service, Geologic Resources Division provides information on geologic features of our national parks. The site is aimed at a young audience (K-8), but is a pleasure to browse for anyone. Organizing the site by geologic features (e.g., Hot Springs, Oldest Rocks, and Volcanoes) allows readers to compare the geology of various national parks and explore maps, photos and other related links.

81

IL-36 in psoriasis.  

PubMed

Psoriasis is a common but severe skin disease with significant health consequences, both physical and psychological. Evidence has emerged during the past several years pointing to a key role for IL-36 in psoriasis. Overexpression of IL-36 in mouse skin leads to a disease quite similar to human plaque psoriasis, and inhibition of IL-36 in human psoriatic skin ameliorates the inflammation. Loss of the natural antagonist of IL-36, IL-36Ra, results in a different, more severe skin disease known as pustular psoriasis. These effects are likely a consequence of the actions of IL-36 both on cells of the immune system as well as on components of skin including fibroblasts and keratinocytes. PMID:22398321

Towne, J E; Sims, J E

2012-08-01

82

Il problema del litio.  

NASA Astrophysics Data System (ADS)

Contents: 1. Introduzione. 2. La nucleosintesi del Big Bang. 3. Il litio nelle stelle di popolazione II. 4. I modelli stellari standard. 5. Il litio negli ammassi aperti. 6. Meccanismi di distruzione "non standard". 7. I modelli non-standard applicati alla popolazione II. 8. L'evoluzione Galattica del litio. 9. Quali stelle producono litio? 10. Il litio come elemento chiave per dare un nome agli oggetti stellari piů minuscoli. 11. Conclusioni.

D'Antona, F.

1995-03-01

83

Acadia National Park: Teachers  

NSDL National Science Digital Library

This National Park Service website contains information on: saving the habitats of peregrine falcons; the water cycle; becoming a junior ranger; and ranger-led school programs, which contain student field activities about the history, biology and geology of the park. Teacher resources include information on a library for educators at the visitor center of the park and teacher guides for preparing to visit the park. The kids' section explains what rangers do, gives tips on leaving no trace in the park, provides a history of Mount Desert Island, and contains an activity to match some park animals to their habitats.

84

Tour of Park Geology: Cave and Karst Parks  

NSDL National Science Digital Library

This Park Geology site provides links to tours of individual National Parks, Monuments, and Recreation Areas with caves and other karst features. Where appropriate, park sites contain park geology information, maps, photographs, geologic research, related links, visitor information, multimedia resources, and teacher features (resources for teaching geology with National Park examples). The list includes places such as Carlsbad Caverns National Park, Mammoth Cave National Park, Sequoia National Park, and the Ozark National Scenic Riverways.

85

Staunton State Park Biological Inventory  

E-print Network

Staunton State Park Biological Inventory Prepared by: Susan Spackman, David Anderson, Jeremy Siemers, Phyllis Pineda, and Jill Handwerk Colorado Natural Heritage Program, Colorado State University: Colorado State Parks, Jefferson and Park Counties, Colorado December, 1999 #12;Staunton State Park

86

78 FR 21413 - Notice of Intent To Repatriate Cultural Items: The Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013, 2014

...Cultural Items: The Field Museum of Natural History, Chicago, IL AGENCY: National Park...SUMMARY: The Field Museum of Natural History, in consultation with the appropriate...request to The Field Museum of Natural History. If no additional claimants come...

2013-04-10

87

Carlsbad Caverns National Park  

NSDL National Science Digital Library

This National Park Service (NPS) website contains details about Carlsbad Caverns National Park in New Mexico. It highlights the natural resources of the park, such as the wilderness, wildlife and caves. The geologic history and formation of caves is covered in detail. There is a teacher's guide with activities, field trip ideas, and factsheets about the park. Topics covered include rocks, erosion, speleothems, mapping caves, fossils, plants and animals, cave bats and fire. Links are provided for more information.

88

Parks In Partnership.  

ERIC Educational Resources Information Center

More than 50 National Park Service (NPS) sites interpret Native cultures or early Native contact with Europeans. In about 30 of those, American Indians, Alaska Natives, or Native Hawaiians, in partnership with the NPS, present their own heritage and issues. Describes Native-run aspects of Sitka National Historical Park, Glacier National Park, and…

Bowman, Sally-Jo

1998-01-01

89

National Parks: Past, Present  

E-print Network

conservation career in 1972 as a ranger-naturalist in Yellowstone National Park and has held several other) for his "outstanding contributions to conservation history, national park policy, and the understandingNational Parks: Past, Present and Future Wallace Stegner Center · Nineteenth Annual Symposium

Tipple, Brett

90

NATIONAL PARK BOUNDARIES  

EPA Science Inventory

The National Park Service has produced a data base of boundaries for its National Parks. A copy of this data was downloaded from the National Parks Service ftp site by Region 10. These digital boundaries represent the best guess and data that could be collected in a short time....

91

Name That Park  

NSDL National Science Digital Library

In this online interactive, learners are introduced to the basic function of Geographic Information System (GIS) maps in relation to national parks. Recognizable park boundaries are presented and learners are given the option to add layers such as lakes, rivers and visitor centers, until the learner is able to identify the park map from a list of choices.

2013-05-15

92

Orienting Park Visitors.  

ERIC Educational Resources Information Center

To utilize park facilities to their fullest, visitors must be well-oriented to the park's physical layout. The results of a study undertaken at Rocky Mountain National Park indicate that information should be readily accessible and easy to use. (DF)

Ormrod, Richard K.

1984-01-01

93

PEABODY PARK TAYLOR GARDEN  

E-print Network

FOUST PARK PEABODY PARK TAYLOR GARDEN KAPLAN COMMONS Start- Peabody Park Trail Start Golf Course TOWER VILLAGE MOORE-STRONG SOUTH SPENCER SPRING GARDEN APARTMENTS PRINT SHOP CHEMICAL SAFETY CARMICHEAL BASEBALL SEATING CAMPUS MINISTRIES 1605 SPRING GARDEN 117 MCIVER VISITOR CENTER SOFTBALL FIELD CAMPUS

Saidak, Filip

94

Orbit control strategy for Lagrange point orbits based on an analytical method  

NASA Astrophysics Data System (ADS)

The periodic or quasi-periodic orbits around collinear Lagrange points present many properties that are advantageous for space missions. These Lagrange point orbits are exponentially unstable. On the basis of an analytical method, an orbit control strategy that is designed to eliminate the dominant unstable components of Lagrange point orbits is developed. The proposed strategy enables the derivation of the analytical expression of nonlinear control force. The control parameter of this strategy can be arbitrarily selected provided that the parameter is considerably lower than the negative eigenvalue of motion equations, and that the energy required keeps the same order of magnitude. The periodic or quasi-periodic orbit of controlled equations remains near the periodic or quasi-periodic orbit of uncontrolled equations.

Lü, Jing; Lu, QiShao; Wang, Qi

2013-04-01

95

IL-19 is a component of the pathogenetic IL-23/IL-17 cascade in psoriasis.  

PubMed

Psoriasis is a common chronic inflammatory disease with characteristic skin alterations and functions as a model of immune-mediated disorders. Cytokines have a key role in psoriasis pathogenesis. Here, we demonstrated that out of 30 individually quantified cytokines, IL-19 showed the strongest differential expression between psoriatic lesions and healthy skin. Cutaneous IL-19 overproduction was reflected by elevated IL-19 blood levels that correlated with psoriasis severity. Accordingly, anti-psoriatic therapies substantially reduced both cutaneous and systemic IL-19 levels. IL-19 production was induced in keratinocytes by IL-17A and was further amplified by tumor necrosis factor-? and IL-22. Among skin cells, keratinocytes were found to be important targets of IL-19. IL-19 alone, however, regulated only a few keratinocyte functions. While increasing the production of S100A7/8/9 and, to a moderate extent, also IL-1?, IL-20, chemokine C-X-C motif ligand 8, and matrix metalloproteinase 1, IL-19 had no clear influence on the differentiation, proliferation, or migration of these cells. Importantly, IL-19 amplified many IL-17A effects on keratinocytes, including the induction of ?-defensins, IL-19, IL-23p19, and T helper type 17-cell- and neutrophil-attracting chemokines. In summary, IL-19 as a component of the IL-23/IL-17 axis strengthens the IL-17A action and might be a biomarker for the activity of this axis in chronic inflammatory disorders. PMID:25046339

Witte, Ellen; Kokolakis, Georgios; Witte, Katrin; Philipp, Sandra; Doecke, Wolf-Dietrich; Babel, Nina; Wittig, Bianca M; Warszawska, Katarzyna; Kurek, Agata; Erdmann-Keding, Magdalena; Kunz, Stefanie; Asadullah, Khusru; Kadin, Marshall E; Volk, Hans-Dieter; Sterry, Wolfram; Wolk, Kerstin; Sabat, Robert

2014-11-01

96

Guadalupe Mountains National Park  

NSDL National Science Digital Library

This National Park Service website offers information on: planning a visit to the park; natural resources such as the geology, wildlife, plants, and wildland fires of the park; cultural history including that of the Mescalero Apaches and the Buffalo Soldiers; and park management issues. A description of the Permian geology of the park includes the rock exposures (composed of reef, back-reef, fore-reef, and basin sediments) which form the ancient fossil reef known as the Capitan Reef of the ancient Delaware Sea.

97

Big Bend National Park  

NSDL National Science Digital Library

This is the National Park Service's homepage for Big Bend National Park. It features links to information on the park's three major environments (mountain, desert, and river) and information on the park's wildlife, geology, and historic and cultural information. The nature and science section has information on the park's animals, plants, ecosystems, and environment. The educational page for teachers includes field trip planning materials, curriculum materials, and professional development information. A kids' page has links to activities, games, and puzzles. There are also links to a photo/multimedia gallery and to news articles.

98

Great Basin National Park  

NSDL National Science Digital Library

This National Park Service site describes the biology of Great Basin's plants and animals; geology and ecology of the Lehman Caves; air quality of the park; and past human activities in the Great Basin such as farming, ranching, and gold mining. There is a list of historical, geological, and archeological dates important to the park and an instructor guide containing activities such as creating a nature notebook and adopting a tree. There is also information on: planning a visit to the park and the Lehman Caves, park projects such as weeding out non-native plants and the reintroduction of Bonneville Cutthroat Trout, and a self-guided geology field trip.

99

Capitol Reef National Park  

NSDL National Science Digital Library

This National Park Service (NPS) website provides an in-depth look at Capitol Reef National Park in Utah. Specifically, this covers the geology and natural resources of the park. There is a general overview of the geology of this area including the Waterpocket fold, Colorado Plateau, Cathedral Valley and erosion. There is a description of various rock colors and how they form, as well as a detailed stratigraphic column illustrating the names, thicknesses, and ancient environments of rocks and formations that exist in the park. The Natural Resources section discusses some of the history and archeology of the park, as well as birds, mammals, plants, reptiles and environmental problems.

100

Position-dependent mass Lagrangians: non-local transformations, Euler-Lagrange invariance and exact solvability  

E-print Network

A general non-local point transformation for position-dependent mass Lagrangians and their mapping into a "constant unit-mass" Lagrangians in the generalized coordinates is introduced. The conditions on the invariance of the related Euler-Lagrange equations are reported. The harmonic oscillator linearization of the PDM Euler-Lagrange equations is discussed through some illustrative examples including harmonic oscillators, shifted harmonic oscillators, a quadratic nonlinear oscillator, and a Morse-type oscillator. The Mathews-Lakshmanan nonlinear oscillators are reproduced and some "shifted" Mathews-Lakshmanan nonlinear oscillators are reported. The mapping of an isotonic nonlinear oscillator into a PDM deformed isotonic oscillator is also discussed.

Omar Mustafa

2014-11-17

101

The National Park Service  

NSDL National Science Digital Library

This is the homepage of the National Park Service. It features links to subpages on special topics such as Parks and Recreation, which inludes links to individual national park pages, and History and Culture, which includes archeological, anthropological, and historical material. The Nature and Science pages feature classroom materials and information on the uses of science in protecting and restoring park ecosystems and research projects which are being conducted in the park system. The Interpretation and Education pages include games, online activities, and material for younger students who are researching park topics, as well as classroom materials for teachers. There are also links to the Park Service online bookshop, news articles, and special features.

102

Chicago Park District  

NSDL National Science Digital Library

The Chicago Park District is one of the largest municipal park systems in the United States, containing over 8,100 acres of green space. All told, the District has 580 parks, including two city conservatories, a number of historic lagoons, and the iconic Clarence Buckingham Memorial Fountain. This website allows visitors the opportunity to learn about the District's mission, history, and long-range planning for existing parks and potential new sites. On the homepage, visitors can use the Find a Park feature to learn about these diverse spaces. Additionally, they can use the I Want To area to learn about park permits, volunteering, and reporting problems within the park system. The Events area is quite a find, as visitors can learn about some of the hundreds of events sponsored each year by the District. Finally, visitors can also use the Doing Business area to learn about the various entrepreneurial activities which are possible via the District.

2013-01-01

103

Theme Park Insider  

NSDL National Science Digital Library

As summer enters full swing, more and more people will travel to America's numerous amusement parks and traveling carnivals. Quite a few of these people would do well to take a look at the Theme Park Insider website for reviews of various parks and the best (and worst) attractions at each particular place of amusement before they venture onto the open road. Edited by Robert Niles, the site contains reviews of new amusement park rides, an "Accident Watch" (which documents the latest accidents at each park), and reviews of theme park hotels as well. The site also has a number of discussion boards for visitors to chime in with their own take on a number of topics, such as which rides have the longest rides and general amusement park lore.

Niles, Robert.

104

Yellowstone National Park  

NSDL National Science Digital Library

This National Park Service website highlights the nature and features found in this park. It provides information about the geology of park (Old Faithful, Mammoth Hot Springs, Norris, Canyon, West Thumb, Bridge Bay, Tower-Roosevelt), geothermal features (hot springs, mud pots, fumaroles, geysers), wildlife (bison, wolves, mountain lions, elk, birds, bears, coyotes), fish, fire, wetland resources, and the famous sand verbena plant found only in Yellowstone. There are also many publications dealing with environmental assessments, project reports and park plans available to download. The history and archeology of the park are covered as well. Live webcams show visitors updated images of Old Faithful, Mammoth Hot Springs and a fire camera on Mt. Washburn. Online tours also take visitors to the Old Faithful area, the South section of the park, the North section of the park and to Mammoth Hot Springs.

105

Resolution of the Gross-Pitaevskii equation with the imaginary-time method on a Lagrange mesh.  

PubMed

The Lagrange-mesh method is an approximate variational calculation which has the simplicity of a mesh calculation. Combined with the imaginary-time method, it is applied to the iterative resolution of the Gross-Pitaevskii equation. Two variants of a fourth-order factorization of the exponential of the Hamiltonian and two types of mesh (Lagrange-Hermite and Lagrange-sinc) are employed and compared. The accuracy is checked with the help of these comparisons and of the virial theorem. The Lagrange-Hermite mesh provides very accurate results with short computing times for values of the dimensionless parameter of the nonlinear term up to 10?. For higher values up to 10?, the Lagrange-sinc mesh is more efficient. Examples are given for anisotropic and nonseparable trapping potentials. PMID:21230613

Baye, D; Sparenberg, J-M

2010-11-01

106

Interleukin-1 (IL-1) Pathway  

NSDL National Science Digital Library

The interleukin-1 (IL-1) family of cytokines comprises 11 proteins (IL-1F1 to IL-1F11) encoded by 11 distinct genes in humans and mice. IL-1–type cytokines are major mediators of innate immune reactions, and blockade of the founding members IL-1? or IL-1? by the interleukin-1 receptor antagonist (IL-1RA) has demonstrated a central role of IL-1 in a number of human autoinflammatory diseases. IL-1? or IL-1? rapidly increase messenger RNA expression of hundreds of genes in multiple different cell types. The potent proinflammatory activities of IL-1? and IL-1? are restricted at three major levels: (i) synthesis and release, (ii) membrane receptors, and (iii) intracellular signal transduction. This pathway summarizes extracellular and intracellular signaling of IL-1? or IL-1?, including positive- and negative-feedback mechanisms that amplify or terminate the IL-1 response. In response to ligand binding of the receptor, a complex sequence of combinatorial phosphorylation and ubiquitination events results in activation of nuclear factor ?B signaling and the JNK and p38 mitogen-activated protein kinase pathways, which, cooperatively, induce the expression of canonical IL-1 target genes (such as IL-6, IL-8, MCP-1, COX-2, I?B?, IL-1?, IL-1?, MKP-1) by transcriptional and posttranscriptional mechanisms. Of note, most intracellular components that participate in the cellular response to IL-1 also mediate responses to other cytokines (IL-18 and IL-33), Toll-like-receptors (TLRs), and many forms of cytotoxic stresses.

Axel Weber (Germany; Justus-Liebig-University Giessen REV)

2010-01-19

107

76 FR 28067 - Notice of Intent To Repatriate Cultural Items: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013, 2014

...Cultural Items: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History (Field Museum), Chicago, IL, that...In 1999, the Field Museum of Natural History acquired the cultural items as a...

2011-05-13

108

76 FR 28067 - Notice of Intent To Repatriate Cultural Items: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013, 2014

...Cultural Items: Field Museum of Natural History, Chicago, IL AGENCY: National Park...possession of the Field Museum of Natural History (Field Museum), Chicago, IL, that...the items to the Field Museum of Natural History. The items were accessioned into...

2011-05-13

109

Fruit and Spice Park Park n r a n  

E-print Network

1 Fruit and Spice Park Park n r a n 24801 S.W. 187th Avenue Homestead, Florida 33031 Main: 305-247 in 1924 and organi ed in 1926. n 1944 Mar Heinlein ecame the rst Superintendent of the Redland Fruit & Spice Park. The park is now known as the Preston B. Bird/Mar Heinlein Fruit & Spice Park. The South ade

Koptur, Suzanne

110

Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma  

PubMed Central

Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, hyper secretion of mucus, edema and airway hyper responsiveness (AHR), mucus secretion and thickening of the basement membrane underlying the airway epithelium. During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. It was believed that airway inflammation is orchestrated by allergen specific T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. Th17 cell may have a role in severe asthma and chronic obstructive pulmonary disease (COPD). Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor-? and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. Cytokines are important in asthma and play a critical role in orchestrating the allergic inflammatory response, although the precise role of each cytokine remains to be determined. The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. The potential therapeutic applications emerging from the roles of these cytokines will be discussed as well. PMID:24949298

Farahani, Rahim; Sherkat, Roya; Hakemi, Mazdak Ganjalikhani; Eskandari, Nahid; Yazdani, Reza

2014-01-01

111

Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma.  

PubMed

Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, hyper secretion of mucus, edema and airway hyper responsiveness (AHR), mucus secretion and thickening of the basement membrane underlying the airway epithelium. During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. It was believed that airway inflammation is orchestrated by allergen specific T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. Th17 cell may have a role in severe asthma and chronic obstructive pulmonary disease (COPD). Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor-? and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. Cytokines are important in asthma and play a critical role in orchestrating the allergic inflammatory response, although the precise role of each cytokine remains to be determined. The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. The potential therapeutic applications emerging from the roles of these cytokines will be discussed as well. PMID:24949298

Farahani, Rahim; Sherkat, Roya; Hakemi, Mazdak Ganjalikhani; Eskandari, Nahid; Yazdani, Reza

2014-01-01

112

Extrasolar Planetary Dynamics with a Generalized Planar Laplace-Lagrange Secular Theory  

Microsoft Academic Search

The dynamical evolution of nearly half of the known extrasolar planets in multiple-planet systems may be dominated by secular perturbations. The commonly high eccentricities of the planetary orbits calls into question the utility of the traditional Laplace-Lagrange (LL) secular theory in analyses of the motion. We analytically generalize this theory to fourth order in the eccentricities, compare the result with

Dimitri Veras; Philip J. Armitage

2007-01-01

113

A Scalable Substructuring Method By Lagrange Multipliers For Plate Bending Problems  

Microsoft Academic Search

. We present a new Lagrange multiplier based domain decomposition method forsolving iteratively systems of equations arising from the finite element discretization of plate bendingproblems. The proposed method is essentially an extension of the FETI substructuring algorithmto the biharmonic equation. The main idea is to enforce continuity of the transversal displacementfield at the subdomain crosspoints throughout the preconditioned conjugate gradient

Charbel Farhat; Jan Mandel; Radek Tezaur

1997-01-01

114

Field theory and weak Euler-Lagrange equation for classical particle-field systems.  

PubMed

It is commonly believed as a fundamental principle that energy-momentum conservation of a physical system is the result of space-time symmetry. However, for classical particle-field systems, e.g., charged particles interacting through self-consistent electromagnetic or electrostatic fields, such a connection has only been cautiously suggested. It has not been formally established. The difficulty is due to the fact that the dynamics of particles and the electromagnetic fields reside on different manifolds. We show how to overcome this difficulty and establish the connection by generalizing the Euler-Lagrange equation, the central component of a field theory, to a so-called weak form. The weak Euler-Lagrange equation induces a new type of flux, called the weak Euler-Lagrange current, which enters conservation laws. Using field theory together with the weak Euler-Lagrange equation developed here, energy-momentum conservation laws that are difficult to find otherwise can be systematically derived from the underlying space-time symmetry. PMID:25375609

Qin, Hong; Burby, Joshua W; Davidson, Ronald C

2014-10-01

115

The Lagrange-Jacobi Equation and Velocity Dispersion for Expanding Gravitating Systems  

NASA Astrophysics Data System (ADS)

The Lagrange-Jacobi equation has been studied for gravitating systems that expand in accordance with the Hubble law. An expression for the velocity dispersion has been found. The cases are also considered when the system is embedded into a gravitating or antigravitating background

Ossipkov, L. P.

2014-01-01

116

On the Nature of the Microwave Background at the Lagrange 2 Point. Part I  

Microsoft Academic Search

In this work, the nature of the microwave background is discussed. It is advanced that the 2.725 K monopole signal, first detected by Penzias and Wilson, originates from the Earth and therefore cannot be detected at the Lagrange 2 point (L2). Results obtained by the COBE, Relikt-1, and WMAP satellites are briefly reviewed. Attention is also placed on the upcoming

Pierre-Marie Robitaille

117

Nonsmooth backstepping design for motion control of a class of Euler-Lagrange systems  

Microsoft Academic Search

A nonsmooth backstepping design method is proposed to solve motion control problem of a class of Eular-Lagrange systems. Compared with the typical backstepping design method, the virtual control selected in nonsmooth backstepping procedure is designed to be nonsmooth but Lipschitz continuous such that the flexible feedback gain can be abtained according to the error regions. It results that the performance

Zheng Kai; Zhang Guojiang; Du Jialu; Yang Ming

2010-01-01

118

Observer design for euler lagrange systems: application to path following control of an underactuated surface vessel  

Microsoft Academic Search

This paper presents a practical method to design an output feedback controller for a general mechanical system described by Euler Lagrange equations. An application of such an observer is formulated to path following controller for an underactuated surface vessel moving in a horizontal plan. The surface vessel is underactuated in the sway direction and has only position and orientation measurement

Jawhar Ghommam; Faical Mnif; A. Benali; Gérard Poisson

2007-01-01

119

A LAGRANGE-MULTIPLIER APPROACH FOR THE NUMERICAL SIMULATION OF AN INEXTENSIBLE MEMBRANE OR THREAD  

E-print Network

A LAGRANGE-MULTIPLIER APPROACH FOR THE NUMERICAL SIMULATION OF AN INEXTENSIBLE MEMBRANE OR THREAD. The functional analysis of the problem allows to determine which boundary conditions are needed for this problem condition for the stress at the interface. An elastic thread is fully characterised by its bending

Saramito, Pierre

120

Application of "AIC" to Wald and Lagrange Multiplier Tests in Covariance Structure Analysis.  

ERIC Educational Resources Information Center

Some efficient procedures are proposed for using the Akaike Information Criterion (H. Akaike, 1987), an alternative to the conventional chi-square goodness of fit test, in covariance structure analysis based on backward search through the Wald test to impose constraints and forward search through the Lagrange test to release constraints. (SLD)

Chou, Chih-Ping; Bentler, P. M.

1996-01-01

121

Lagrange Principle and the Distribution of Wealth J. Mimkes, G. Willis*,  

E-print Network

Lagrange Principle and the Distribution of Wealth J. Mimkes, G. Willis*, Physics Department of energy g(x). In the discussion of wealth distribution it may be demonstrated that both aspects will apply. The stochastic aspect of physics leads to a Boltzmann distribution of wealth, which applies to the majority

Mimkes, JĂĽrgen

122

CONVERGENT DISCRETIZATION OF HEAT AND WAVE MAP FLOWS TO SPHERES USING APPROXIMATE DISCRETE LAGRANGE MULTIPLIERS  

E-print Network

CONVERGENT DISCRETIZATION OF HEAT AND WAVE MAP FLOWS TO SPHERES USING APPROXIMATE DISCRETE LAGRANGE to approximate the harmonic map heat flow, and the wave map into spheres. The proposed finite-element based.3) u(0, ·) = u0 in ,(1.4) and B) the wave map flow into the sphere Sm-1, utt - u = |u|2 - | ut |2 u

Bartels, Soeren

123

A comparison of numerical integrating algorithms by trapezoidal, Lagrange, and spline approximation  

Microsoft Academic Search

In the trapezoidal method, linear interpolation between data points tends to overestimate or underestimate the area, depending on the concavity of the curve. In some instances, area estimates can be obtained by linear interpolation of logarithmically transformed data. Two alternative algorithms based on known interpolating functions have been implemented for area calculations. In the Lagrange method, the linear interpolations are

K. C. Yeh; K. C. Kwan

1978-01-01

124

Searching for life with the Terrestrial Planet Finder: Lagrange point options for a formation flying interferometer  

E-print Network

Searching for life with the Terrestrial Planet Finder: Lagrange point options for a formation. The Terrestrial Planet Finder (TPF) is one of the key missions in NASA's Astronomical Search for Origins search for origins; Searching for life; Terrestrial Planet Finder; TPF; Halo orbit; L2; Heliocentric

Barcelona, Universitat de

125

Globally stable adaptive formation control of Euler-Lagrange agents via potential functions  

Microsoft Academic Search

This paper proposes a formation control strategy for uncertain Euler-Lagrange mobile agents based on artificial potential functions and robust adaptive control. A desired kinematic model is derived from a given potential function. The system parametric uncertainties and external disturbances are compensated by a robust adaptive control algorithm named binary adaptive control which combines the good transient properties and robustness of

Ademir Rodrigues Pereira; Liu Hsu; Romeo Ortega

2009-01-01

126

Tennessee State Parks  

NSDL National Science Digital Library

People might know Tennessee for its fabulous Great Smoky Mountains, but have you ever heard of the Cedars of Lebanon or Fall Creek Falls? Oh yes, those two gems are just a small part of the Tennessee State Park system. After looking at some of the beautiful images on the Tennessee State Parks homepage, visitors can explore the Popular Places People Want to Go section to get a taste of the diverse hiking trails, restaurants, camp sites, and other features that are contained throughout the park system. Visitors can also look over over a dozen topical areas, including What to do?, Park Information, and Resource Management. Policy enthusiasts will appreciate the "Estimated Economic Impacts of Tennessee State Parks" report, that is also featured on the homepage, and travelers will love the "Upcoming Events at Tennessee State Parks" area, as it provides a taste of what they might expect on a visit to the Volunteer State.

127

Restoring naturalness to national parks  

Microsoft Academic Search

National park resource management planning requires ecological information describing the objectives to be achieved. This information must be quantitative and unambiguous. Since most acts creating United States national parks, beginning with the Yellowstone National Park Act of 1872, specify that these parks should be maintained in a natural condition, resource management objectives for each national park must be defined in

Thomas M. Bonnicksen; Edward C. Stone

1985-01-01

128

A Desert Park  

NSDL National Science Digital Library

This National Park Service site describes the desert and oasis ecosystems of Joshua Tree National Park as well as the cultural history of humans occupying the area. Nature sections describe the animals, plants, cryptobiotic crusts, and the geology of the park. There are sections on environmental factors such as air quality, disturbed lands, exotic species and fire ecology. There is also information on natural history and cultural history education programs provided for different grade levels.

129

Utah Park Brochure  

NSDL National Science Digital Library

You have been asked to create a brochure for one of Utah\\'s many state or national parks to advertise to potential visitors. Overview: After reading Deathwatch, you have now become somewhat of an expert on desert life and survival. Because of your knowledge, you have been asked to create a brochure for one of the state or national parks here in Utah. First, you will select the park or ...

Mrs. Kingsford

2007-01-26

130

Mapping the National Parks  

NSDL National Science Digital Library

This website contains a collection of maps documenting the history, cultural aspects and geological formations of areas that eventually became National Parks. The areas highlighted are Acadia National Park, Yellowstone National Park, the Grand Canyon, and the Great Smoky Mountains. The collection consists of approximately 200 maps dating from the 17th century to the present, reflecting early mapping of these areas. This database is searchable by keyword, geographic location, subject, map creator, or title.

131

Interleukin (IL)-23 Suppresses IL-10 in Inflammatory Bowel Disease*  

PubMed Central

Interleukin (IL)-10 plays an important role in immune regulation in the intestine. Immune deregulation is suggested in the pathogenesis of inflammatory bowel disease (IBD). This study aims to elucidate the role of IL-23 in the suppression of IL-10 in the IBD intestinal mucosa. Surgically removed colon specimens were obtained from 16 IBD patients. The expressions of IL-10, IL-23, and IgA in the specimens were examined at the protein and gene transcriptional levels. The gene transcription of IL-10 was assessed by chromatin immunoprecipitation assay and promoter accessibility assay. The levels of IgA and IL-10 were significantly lower, whereas the levels of IL-23 were higher, in IBD specimens than in normal controls. The levels of IgA and IL-10 were negatively correlated with the infiltration of inflammatory cells in the IBD mucosa. The production of IL-10 by lamina propria mononuclear cells was lower in the IBD group than in the control group, and these levels could be enhanced by blocking IL-23. The gene transcription of IL-10 was significantly suppressed in CD4+ T cells of IBD mucosa; this phenomenon could be replicated in vitro by adding IL-23 in the culture of polarized Th2 cells. Overexpression of IL-23 in the intestinal mucosa suppresses the production of IL-10, which weakens the defensive barrier by reducing the production of IgA in the gut. PMID:22158873

Liu, Zhanju; Feng, Bai-Sui; Yang, Shao-Bo; Chen, Xiao; Su, Jingling; Yang, Ping-Chang

2012-01-01

132

ARTS & SCIENCES Paradise Park  

E-print Network

COLLEGE OF ARTS & SCIENCES Paradise Park Moderation in Belief The Attraction of Sedimentary Rocks SCIENCES Gauging Protein Activity in Cancer Treatment ... The Attraction of Sedimentary Rocks ... Davis

Napier, Terrence

133

Petrified Forest National Park  

NSDL National Science Digital Library

This National Park Service website offers reference sections on: park wildlife such as reptiles, pronghorns, and the Gunnison prairie dog; the archaeology of park petroglyphs, including some that may be solar calendars; the geology and main features of the Painted Desert; paleontology, which describes dinosaurs of the area; and petrified wood, which explains the petrification process and how the different colors of petrified wood are produced. There are also tips for avoiding diseases such as hantavirus, the plague, and rabies while in the park.

134

Transportation and Parking Changes & Reminders  

E-print Network

with Prox Cards: o Hold Prox Card Still within 18 inches of the Reader o Do not waive Prox Card in front of Reader #12;Visitor Parking REMEMBER - Weekend Parking Garage Rate - Weekend visitors to campus must park

Huang, Jianyu

135

Splendor In The Parks.  

ERIC Educational Resources Information Center

Civilization is more and more intruding on the esthetic and recreational resources of the National Park System. Increased attention must be paid to controlling noise, pollution, and even the effects of urban lighting which detract from the enjoyment of the parks. (RE)

Smith, Anthony Wayne

1979-01-01

136

Glacier (?) National Park  

NSDL National Science Digital Library

Spreadsheets Across the Curriculum/Geology of National Parks module. Students examine data about the disappearing glaciers in the park; after calculating percentage change in the number of glaciers from 1850 to 2000, they interpolate to estimate when Grinnell glacier will be gone.

Module by: Judy McIlrath, University of South Florida Cover Page by: Len Vacher and Denise Davis, University of South Florida

137

Acadia National Park Panorama  

USGS Multimedia Gallery

A panorama of Acadia National Park with Dorr and Cadillac Mountains on the right side, taken from Cadillac Mountain Road. At 1,528 feet in elevation, Cadillac Mountain is the highest point in Acadia National Park, and is composed of a unique granite, the Cadillac Mountain granite unit....

138

Bryce Canyon National Park  

NSDL National Science Digital Library

The Bryce Canyon National Park website contains geology, history, and nature reference sections as well as maps, a photo gallery, and information for planning a trip to the park. The kids page includes the GeoDetectives earth history and physical earth science program. This program has units on earth systems, rocks and minerals, landforms, hydrology, plate tectonics, and paleontology.

139

Yellowstone National Park Facts  

NSDL National Science Digital Library

This Yellowstone National Park website provides a fact sheet with a wide range of physical and cultural information. Key topics include general park facts, wildlife, flora, geology, Yellowstone Lake, cultural resources, visitation, facilities, roads, trails, and the latitude/longitude of several significant features.

Yellowstone National Park

140

Mammoth Cave National Park  

NSDL National Science Digital Library

The homepage of Mammoth Cave National Park provides visitors with information on tour schedules, surface activities, lodging and camping, and tips on touring caves. Teachers can access an extensive selection of curricular materials, fact sheets and activities for kids, a glossary, and links to other educational programs and sites. Other materials include maps and publications, an image gallery, and links to the park's newsletter.

141

Amusement Park Physics  

NSDL National Science Digital Library

Students will research various types of amusement park rides and use their findings to design a feasible ride of their own. They will summarize their findings and present their ride design to the class. Each student will then write a persuasive letter to a local amusement park describing the reasons their ride design is the best.

Janet Fox

2012-06-25

142

PARKING OFFICER Position Information  

E-print Network

or emergency situations. Make and set up signs for VIP guests or events, emtpy pay permit machines, provide and parking facilities and the ability to act and resolve parking and traffic problems. Ability to write)594-7099. EM Equal Employment Opportunity SDSU IS AN EQUAL OPPORTUNITY EMPLOYER AND DOES NOT DISCRIMINATE

Ponce, V. Miguel

143

Yellowstone National Park Interactive Map  

NSDL National Science Digital Library

This Yellowstone National Park Map is a handy way to quickly find locations and buildings located in the park. It is currently the most detailed map of Yellowstone national park that can be viewed online. The pull down menu has Yellowstone features such as geyser basins, campgrounds, trails, mountains, and historical points and park structures. Popular geysers, and park locations such as Norris geyser basin, Yellowstone visitor centers, park housing, lodging, and park dining can be easily found. All Yellowstone National Park named structures are indexed so you can easily find the sites that you want to locate.

NPS Source: CENSUS

144

Florida State Parks  

NSDL National Science Digital Library

The modern Florida State Parks system was created in 1935, and their programs include parks all the way from the St. Augustine area to the Keys. Their homepage brings together cultural, historical, and scientific materials related to the various sites in the state system. The website includes information on each park, along with interactive features on African American sites in the state and notable battlegrounds. Along the top of the page, visitors can use sections such as "Find a Park" and "Stay the Night" to plan their journey through the state. Each park entry also contains information about the site's history, along with detailed information about ranger programs, special music events, and so on. Finally, visitors can stay in touch via Twitter and other social media.

145

Defunct Amusement Parks  

NSDL National Science Digital Library

While there are many sites on existing amusement parks, this particular Web site contains detailed information on "pleasure palaces" that have gone out of business or that have since been demolished. Created and maintained by Joel Styer, the site features an interactive map of the United States that allows visitors to click on any one of the states to find out information about now-defunct amusement parks. Many of the former parks have additional material available for viewing, such as photographs, postcards, and brief essays and personal remembrances. Also, there is an extensive links page, which directs visitors to other sites dealing with different aspects of amusement park memorabilia such as popular rides from the past and newsgroups. The site also has different contact information for persons seeking to donate materials and recollections related to amusement parks.

146

Impact of IL -9 and IL-33 in mast cells.  

PubMed

Cytokines serve as chemical communicators from one cell to another and most of them have pro-inflammatory activity. Mast cells have been recognised as important mediators of the pathogenesis of allergy and inflammation, suggesting a role for IL-33-mediated mast cell activation. IL-33 was recently identified as a ligand for the orphan IL-1 family receptor T1/ST2 and is mainly expressed by mast cells, fibroblasts, epithelial cells, and endothelial cells, particularly in high endothelial venules. IL-33 is a potent inducer of pro-inflammatory cytokines such as IL-1, IL-6, IL-13 and TNF, and chemokines (MCP-1), by mast cells. Substance P is capable to induce VEGF from mast cells, and IL-33, the newest pro-inflammatory member of the IL-1 cytokine family, augments the effect of SP in VEGF transcription and translation protein. IL-9 is a pleiotropic and is expressed by multiple T helper (TH) cell subsets. IL-9 promotes the expression of mast cell pro-inflammatory cytokines in vitro and is involved in Th2 responses. This article focuses on recent developments of mast cells, IL-9 and IL-33, and recent literature and investigations were reviewed. PMID:23241108

Sabatino, G; Nicoletti, M; Neri, G; Saggini, A; Rosati, M; Conti, F; Cianchetti, E; Toniato, E; Fulcheri, M; Caraffa, A; Antinolfi, P; Frydas, S; Pandolfi, F; Potalivo, G; Galzio, R; Conti, P; Theoharides, T C

2012-01-01

147

Interleukin-13 (IL-13) Pathway  

NSDL National Science Digital Library

Interleukin-13 (IL-13), like IL-4, is a cytokine produced by TH2 type helper T cells in response to signaling through the T cell antigen receptor and by mast cells and basophils upon cross-linkage of the high-affinity receptor for immunoglobulin E (IgE). It is also produced by activated eosinophils. IL-13 induces many of the same responses as IL-4 and shares a receptor subunit with IL-4. IL-13 has been implicated in airway hypersensitivity and mucus hypersecretion, inflammatory bowel disease, and parasitic nematode expulsion.

Ann Kelly-Welch (Marlene and Stewart Greenebaum Cancer Center and University of Maryland; Program in Oncology and Department of Microbiology and Immunology REV)

2005-07-19

148

Modified Gauss-Bonnet gravity with Lagrange multiplier constraint as mimetic theory  

E-print Network

In this paper we propose and extensively study mimetic $f({\\cal G})$ modified gravity models, with various scenarios of cosmological evolution, with or without extra matter fluids. The easiest formulation is based on the use of Lagrange multiplier constraint. In certain versions of this theory, it is possible to realize accelerated expansion of the Universe or even unified evolution which includes inflation with dark energy, and at the same time in the same theoretical framework, dark matter is described by the theory. This is achieved by the re-parametrization of the metric tensor, which introduces a new degree of freedom in the cosmological equations and leads to appearance of the mimetic "dark matter" component. In the context of mimetic $f({\\cal G})$ theory, we also provide some quite general reconstruction schemes, which enable us to find which $f({\\cal G})$ gravity generates a specific cosmological evolution. In addition, we also provide the general reconstruction technique for Lagrange multiplier $f({\\...

Astashenok, Artyom V; Oikonomou, V K

2015-01-01

149

Lagrange-SQP Techniques for the Control Constrained Optimal Boundary Control for the Burgers Equation  

Microsoft Academic Search

A Lagrange-Newton-SQP method is analyzed for the optimal control of the Burgers equation. Boundary controls are given, which are restricted by pointwise lower and upper bounds. The convergence of the method is proved in appropriate Banach spaces. This proof is based on a second-order sufficient optimality condition and the theory of Newton methods for generalized equations in Banach spaces. For

S. Volkwein

2003-01-01

150

Euler-Lagrange Equations for Nonlinearly Elastic Rods with Self-Contact  

Microsoft Academic Search

.  ?We derive the Euler-Lagrange equations for nonlinearly elastic rods with self-contact. The excluded-volume constraint is\\u000a formulated in terms of an upper bound on the global curvature of the centre line. This condition is shown to guarantee the\\u000a global injectivity of the deformation of the elastic rod. Topological constraints such as a prescribed knot and link class\\u000a to model knotting and

Friedemann Schuricht; Heiko von der Mosel

2003-01-01

151

Quasi-periodic regimes in the transition to unstable Lagrange dynamics  

Microsoft Academic Search

The appearance of a narrow band of quasi-periodic regimes between the regions of periodic (stable) and unstable (in the Lagrange\\u000a sense) dynamics in the space of parameters of a dynamical system has been studied in the case of a model two-dimensional Hnon\\u000a map. It is established that fast breakage of a quasi-periodic regime proceeds via nonlocal bifurcation, whereby an attractor

A. P. Kuznetsov; A. V. Savin

2006-01-01

152

Solving inverse problems involving the Navier–Stokes equations discretized by a Lagrange–Galerkin method  

Microsoft Academic Search

In this article, we are investigating the numerical approximation of an inverse problem involving the evolution of a Newtonian viscous incompressible fluid described by the Navier–Stokes equations in 2D. This system is discretized using a low order finite element in space coupled with a Lagrange–Galerkin scheme for the nonlinear advection operator. We introduce a full discrete linearized scheme that is

Gilles Fourestey; Marwan Moubachir

2005-01-01

153

A variational approach to sparsity optimization based on Lagrange multiplier theory  

NASA Astrophysics Data System (ADS)

Sparsity optimization for linear least squares problems formulated as non-smooth regularization problems are considered in infinite-dimensional sequence spaces ?p with p ? [0, 1]. Necessary optimality conditions in the format of a complementarity system are obtained. A monotonically convergent scheme is developed for the case p ? (0, 1]. For the case p = 0 a primal dual active set strategy based on the Lagrange multiplier rule is proposed and analyzed for special cases.

Ito, Kazufumi; Kunisch, Karl

2014-01-01

154

A Free-Lagrange method for unsteady compressible flow: simulation of a confined cylindrical blast wave  

Microsoft Academic Search

A Free-Lagrange numerical procedure for the simulation of two-dimensional inviscid compressible flow is described in detail.\\u000a The unsteady Euler equations are solved on an unstructured Lagrangian grid based on a density-weighted Voronoi mesh. The flow\\u000a solver is of the Godunov type, utilising either the HLLE (2 wave) approximate Riemann solver or the more recent HLLC (3 wave)\\u000a variant, each adapted

G. J. Ball

1996-01-01

155

A Free-Lagrange method for unsteady compressible flow: simulation of a confined cylindrical blast wave  

Microsoft Academic Search

A Free-Lagrange numerical procedure for the simulation of two-dimensional inviscid compressible flow is described in detail. The unsteady Euler equations are solved on an unstructured Lagrangian grid based on a density-weighted Voronoi mesh. The flow solver is of the Godunov type, utilising either the HLLE (2 wave) approximate Riemann solver or the more recent HLLC (3 wave) variant, each adapted

G. J. Ball

1996-01-01

156

Design a Park  

NSDL National Science Digital Library

In this activity, learners are invited to imagine the park of their dreams! In small groups, learners place moveable pieces on a grid, iterating on their plan together to create a plan for a community park. A variety of park features are offered as choices to include on the map, including a playground, skate park, water features, picnic areas, trails, and more. Like real-world projects, the plan is limited by the realities of space and funds. For younger learners, groups are limited to choosing less than 10 features. Learners ages 9 and up are limited not by the number of features, but by their cost in terms of points: They are challenged to keep track of the points on the park features cards and use less than 250 total points. Some park features, including a natural wetland and ice cream shop, promise to provide revenue back to the community and are worth points. Others, like a skate park or swimming pool, "cost" points. This activity is part of a curriculum designed to engage learners in hands-on engineering challenges.

2014-07-11

157

Parks awash in light pollution  

Microsoft Academic Search

The first-ever nationwide survey of light pollution impacts on the U.S. National Park System has found that light pollution is a pervasive threat to national parks, and interferes with visitors' ability to observe stars and the night sky. The survey, which queried National Park Service (NPS) staff, found that dark night skies are a vital park resource, and that light

Randy Showstack

1999-01-01

158

How to Park: Teen Drivers  

E-print Network

is missing in this picture. As much as you drive your car, it's actu- ally parked 95% of the time! Parking is important to master because: · Almost 70% of vehicular crashes happen while parking. · 14% of all insurance. · 30% of drivers feel it's okay to tap another car's bumper when parallel parking (but it isn't okay

Das, Suman

159

SECTION FOUR: Parking & Traffic Violations  

E-print Network

assessed under the authority of York University Parking and Traffic Regulations within 30 calendar days) Legal action (v) Additional service charges SECTION FIVE: Parking & Traffic Violations 5.0 If a driverSECTION FOUR: Parking & Traffic Violations 4.0 PARKING PRIVILEGES CANCELLED re: Failure to pay

160

Pacific Historic Parks  

NSDL National Science Digital Library

Designed to support and fund educational materials and interpretive programs for four National Parks throughout the Pacific (including the Kalaupapa National Historical Park), the Pacific Historic Parks organization has a visually enticing website. On the homepage, visitors will find information about their work in four sections, including "Education" and "Locations". First-time visitors may want to start by looking over the "Locations" area. Here they will find information about each park, complete with a Google Map interface that will let them learn more about each site. In the "Education" area, visitors can download a copy of their educational brochure and also take a look at several of their booklets for educators. Moving on, the "Audio Tour" area contains a copy of the accompanying brochure for an audio tour narrated by actor Jamie Lee Curtis.

161

Kruger National Park  

Atmospheric Science Data Center

... and to the right of image center is the Palabora Copper Mine, and the water body near upper right is Lake Massingir in Mozambique. ... South Africa showing Kruger Park, the Palabora Copper Mine, and Lake Massingir. project:  MISR category:  ...

2013-04-15

162

CRAIGMILLAR CASTLE PARK  

E-print Network

is for adults using Edinburgh's mental health services. 2010 Craigmillar received the Green Flag Award WIAT of Multiple Deprivation 2009 Before WIAT The park and castle have a long history dating back to the 1300s. One

163

Jurassic Park Safety Audit  

NSDL National Science Digital Library

Using the first 30 minutes of the film Jurassic Park, the student will audit it for violations of safety rules and regulations, OSHA violations, and violations of HASP's. Access to the activity required free and quick registration with ATEEC.

164

The National Park Service: Park Geology  

NSDL National Science Digital Library

A National Park Service (NPS) site primarily composed of three main sections corresponding to the following program areas within the Geologic Resources Division (GRD): Disturbed Lands Restoration and Abandoned Mineral Lands (AML), Mineral Management Programs, and Geology and Soils Programs. Of these, the first two consist principally of textual resources pertaining to Park System procedures, policies, and regulations - as well as reports on example restoration projects with a focus on stream corridor restoration, bioengineering, riparian management, and revegetation. Perhaps of most interest to educators will be the third main program area, the Geology and Soils Programs section. Here are included textual resources pertaining to NPS-GRD programs on cave and karst formations, coastal and shoreline geology, paleontology, soils (e.g., soil biology and soil surveying), geological indicators (geoindicators), and stratigraphy. Lastly, a searchable photographic collection and geologic glossary are available.

165

A novel parking service using wireless networks  

Microsoft Academic Search

Parking is costly and limited in almost every major city in the world. The misparking aggravates the competition of parking slots. Innovative parking systems for meeting near-term parking demand are needed. A probabilistic approach is addressed to model the misparking of the current parking system. To provide an intelligent parking services and to eliminate the misparking, a wireless-based parking service

Gongjun Yan; Michele C. Weigle; Stephan Olariu

2009-01-01

166

Geology Fieldnotes: Great Basin National Park, Nevada  

NSDL National Science Digital Library

This Great Basin National Park site contains park geology information, park maps, visitor information, and teacher features (educational resources and links for teaching geology using National Park examples). The park geology section discusses the region's biogeography, glacial history, and the Lehman Caves. A park map and a features/relief map of the Great Basin National Park are included.

167

Urban Parks: Constraints on Park Visitation  

E-print Network

may not cause them to participate unless there is a simultaneous effort to promote positive attitudes about the outdoors, help people develop their skills, and ensure visitor safety (Crawford and Godbey). Lack of Time Lack of time is the reason... overcome the problem. Leisure constraints are those factors that limit people?s participation in or enjoyment of leisure activities and services (e.g., parks and programs). There are several types of constraints. Lack of Interest and Skills Early...

Scott, David

2006-12-19

168

76 FR 80393 - Notice of Inventory Completion: Field Museum of Natural History, Chicago, IL  

Federal Register 2010, 2011, 2012, 2013, 2014

...Inventory Completion: Field Museum of Natural History, Chicago, IL AGENCY: National Park...SUMMARY: The Field Museum of Natural History has completed an inventory of human remains...may contact the Field Museum of Natural History. Repatriation of the human remains...

2011-12-23

169

Tour of Park Geology: Oldest Rocks  

NSDL National Science Digital Library

This park geology site provides links to tours of individual National Parks, Monuments, and Recreation Areas with the oldest known rocks. The parks are divided at this site into East and West. Where appropriate, for each park, links are provided to park geology, maps, photographs, geologic research, visitor information, multimedia resources, and teacher features (resources for teaching geology using National Park examples). Parks listed include: Voyaguers National Park, Keweenaw National Historic Park, Lake Meade National Recreation Area, and many more.

170

Park Geology: Tour of Basin and Range Parks  

NSDL National Science Digital Library

This site provides links to tours of individual National Parks within the Basin and Range region. Where appropriate for each park, links are provided to park geology, maps, photographs, geologic research, related links, visitor information, multimedia resources, and teacher features. Some of the parks have an expanded geology page that features the geologic time, history, plate tectonics, rocks and minerals, and a virtual field trip of the park. Of particular note is the teacher feature section, which provides educational resources and links for teaching geology with National Park examples.

171

ProvincialParks,Trails,Beaches,andProtectedAreas Provincial Parks, Trails, Beaches,  

E-print Network

ProvincialParks,Trails,Beaches,andProtectedAreas Provincial Parks, Trails, Beaches, and Protected PARKS, TRAILS, BEACHES, AND PROTECTED AREAS TO THE STEERING PANEL February 2010 Cape Chignecto Provincial Park--Gerry Lunn #12;ProvincialParks,Trails,Beaches

Charles, Anthony

172

Investigating Trojan Asteroids at the L4/L5 Sun-Earth Lagrange Points  

NASA Technical Reports Server (NTRS)

Investigations of Earth's Trojan asteroids will have benefits for science, exploration, and resource utilization. By sending a small spacecraft to the Sun-Earth L4 or L5 Lagrange points to investigate near-Earth objects, Earth's Trojan population can be better understood. This could lead to future missions for larger precursor spacecraft as well as human missions. The presence of objects in the Sun-Earth L4 and L5 Lagrange points has long been suspected, and in 2010 NASA's Wide-field Infrared Survey Explorer (WISE) detected a 300 m object. To investigate these Earth Trojan asteroid objects, it is both essential and feasible to send spacecraft to these regions. By exploring a wide field area, a small spacecraft equipped with an IR camera could hunt for Trojan asteroids and other Earth co-orbiting objects at the L4 or L5 Lagrange points in the near-term. By surveying the region, a zeroth-order approximation of the number of objects could be obtained with some rough constraints on their diameters, which may lead to the identification of potential candidates for further study. This would serve as a precursor for additional future robotic and human exploration targets. Depending on the inclination of these potential objects, they could be used as proving areas for future missions in the sense that the delta-V's to get to these targets are relatively low as compared to other rendezvous missions. They can serve as platforms for extended operations in deep space while interacting with a natural object in microgravity. Theoretically, such low inclination Earth Trojan asteroids exist. By sending a spacecraft to L4 or L5, these likely and potentially accessible targets could be identified.

John, K. K.; Graham, L. D.; Abell, P. A.

2015-01-01

173

FACING NORTHWEST TOWARD NORTHERN END OF PARK Candler Park ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FACING NORTHWEST TOWARD NORTHERN END OF PARK - Candler Park Historic District, Roughly bounded by Moreland, Dekalb, McLendon & Harold Avenues, Matthews Street & Clifton Terrace, Atlanta, Fulton County, GA

174

FACING NORTHEAST OF NORTHERN BOUNDARY OF PARK Candler Park ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FACING NORTHEAST OF NORTHERN BOUNDARY OF PARK - Candler Park Historic District, Roughly bounded by Moreland, Dekalb, McLendon & Harold Avenues, Matthews Street & Clifton Terrace, Atlanta, Fulton County, GA

175

Accuracy of Lagrange-sinc functions as a basis set for electronic structure calculations of atoms and molecules  

NASA Astrophysics Data System (ADS)

We developed a self-consistent field program based on Kohn-Sham density functional theory using Lagrange-sinc functions as a basis set and examined its numerical accuracy for atoms and molecules through comparison with the results of Gaussian basis sets. The result of the Kohn-Sham inversion formula from the Lagrange-sinc basis set manifests that the pseudopotential method is essential for cost-effective calculations. The Lagrange-sinc basis set shows faster convergence of the kinetic and correlation energies of benzene as its size increases than the finite difference method does, though both share the same uniform grid. Using a scaling factor smaller than or equal to 0.226 bohr and pseudopotentials with nonlinear core correction, its accuracy for the atomization energies of the G2-1 set is comparable to all-electron complete basis set limits (mean absolute deviation ?1 kcal/mol). The same basis set also shows small mean absolute deviations in the ionization energies, electron affinities, and static polarizabilities of atoms in the G2-1 set. In particular, the Lagrange-sinc basis set shows high accuracy with rapid convergence in describing density or orbital changes by an external electric field. Moreover, the Lagrange-sinc basis set can readily improve its accuracy toward a complete basis set limit by simply decreasing the scaling factor regardless of systems.

Choi, Sunghwan; Hong, Kwangwoo; Kim, Jaewook; Kim, Woo Youn

2015-03-01

176

Accuracy of Lagrange-sinc functions as a basis set for electronic structure calculations of atoms and molecules.  

PubMed

We developed a self-consistent field program based on Kohn-Sham density functional theory using Lagrange-sinc functions as a basis set and examined its numerical accuracy for atoms and molecules through comparison with the results of Gaussian basis sets. The result of the Kohn-Sham inversion formula from the Lagrange-sinc basis set manifests that the pseudopotential method is essential for cost-effective calculations. The Lagrange-sinc basis set shows faster convergence of the kinetic and correlation energies of benzene as its size increases than the finite difference method does, though both share the same uniform grid. Using a scaling factor smaller than or equal to 0.226 bohr and pseudopotentials with nonlinear core correction, its accuracy for the atomization energies of the G2-1 set is comparable to all-electron complete basis set limits (mean absolute deviation ?1 kcal/mol). The same basis set also shows small mean absolute deviations in the ionization energies, electron affinities, and static polarizabilities of atoms in the G2-1 set. In particular, the Lagrange-sinc basis set shows high accuracy with rapid convergence in describing density or orbital changes by an external electric field. Moreover, the Lagrange-sinc basis set can readily improve its accuracy toward a complete basis set limit by simply decreasing the scaling factor regardless of systems. PMID:25747070

Choi, Sunghwan; Hong, Kwangwoo; Kim, Jaewook; Kim, Woo Youn

2015-03-01

177

The Lagrange Points in a Binary Black Hole System: Applications to Electromagnetic Signatures  

NASA Technical Reports Server (NTRS)

We study the stability and evolution of the Lagrange points L_4 and L-5 in a black hole (BH) binary system, including gravitational radiation. We find that gas and stars can be shepherded in with the BH system until the final moments before merger, providing the fuel for a bright electromagnetic counterpart to a gravitational wave signal. Other astrophysical signatures include the ejection of hyper-velocity stars, gravitational collapse of globular clusters, and the periodic shift of narrow emission lines in AGN.

Schnittman, Jeremy

2010-01-01

178

Field theory and weak Euler-Lagrange equation for classical particle-field systems  

SciTech Connect

It is commonly believed that energy-momentum conservation is the result of space-time symmetry. However, for classical particle-field systems, e.g., Klimontovich-Maxwell and Klimontovich- Poisson systems, such a connection hasn't been formally established. The difficulty is due to the fact that particles and the electromagnetic fields reside on different manifolds. To establish the connection, the standard Euler-Lagrange equation needs to be generalized to a weak form. Using this technique, energy-momentum conservation laws that are difficult to find otherwise can be systematically derived.

Qin, Hong [PPPL; Burby, Joshua W [PPPL; Davidson, Ronald C [PPPL

2014-10-01

179

Domain decomposition methods for nonconforming finite element spaces of Lagrange-type  

NASA Technical Reports Server (NTRS)

In this article, we consider the application of three popular domain decomposition methods to Lagrange-type nonconforming finite element discretizations of scalar, self-adjoint, second order elliptic equations. The additive Schwarz method of Dryja and Widlund, the vertex space method of Smith, and the balancing method of Mandel applied to nonconforming elements are shown to converge at a rate no worse than their applications to the standard conforming piecewise linear Galerkin discretization. Essentially, the theory for the nonconforming elements is inherited from the existing theory for the conforming elements with only modest modification by constructing an isomorphism between the nonconforming finite element space and a space of continuous piecewise linear functions.

Cowsar, Lawrence C.

1993-01-01

180

Geology of National Parks  

NSDL National Science Digital Library

Have you ever wondered what it would be like to take a historic tour of the Colorado River Canyon? Wonder no more, as this site from the U.S. Geological Survey makes just such a sojourn possible. Drawing on thousands of historic and contemporary photographs, views, documents, and other items, the USGS has created these fine 3D and photographic tours of dozens of national parks. On the site, visitors will find an alphabetical list of the parks, along with links to the 3D image galleries, standard image galleries, and selected online field guides. There's a great deal to recommend here, but visitors should definitely look at the stereograph images from the Powell Survey Expeditions of the Colorado River from 1871 and 1872 (in the "Other park-related resources" section) and the guidebook titled "Where's the San Andreas Fault?" Along with providing entertaining edification, this site might also spark some ideas for an upcoming trip.

181

Regulatory effects of C5a on IL-17A, IL-17F, and IL-23  

PubMed Central

The complement anaphylatoxin, C5a, through binding to its receptors (C5aR or C5L2), has important biological properties for recruitment and activation of phagocytes. C5a has been identified as a powerful modulator of Toll-like receptor-induced cytokine and chemokine production by macrophages. Both the complement system and the interleukin (IL)-17 cytokine family protect against extracellular pathogens by enhancing innate immune functions. On the basis of its concentration, C5a can either positively or negatively modulate the production by macrophages of IL-17 family members as well as IL-23 via the phosphatidylinositol 3-kinase/Akt signaling cascade. C5a can also affect the production and maintenance of IL-17-producing T cells. Using C5a, C5aR, or C5L2 deficiency or blockade, IL-17/IL-23 production and/or IL-17-dependent disease progression has been shown to be substantially modified. The contributions of C5a interaction with its receptors in the production of IL-17/IL-23 and promotion of IL-17-dependent immune responses are reviewed. PMID:23316190

Grailer, Jamison J.; Bosmann, Markus; Ward, Peter A.

2013-01-01

182

Parking space detection using ultrasonic sensor in parking assistance system  

Microsoft Academic Search

This paper deals with parking space detection by using ultrasonic sensor. Using the multiple echo function, the accuracy of edge detection was increased. After inspecting effect on the multiple echo function in indoor experiment, we applied to 11 types of vehicles in real parking environment and made experiments on edge detection with various values of resolution. We can scan parking

Wan-Joo Park; Byung-Sung Kim; Dong-Eun Seo; Dong-Suk Kim; Kwae-Hi Lee

2008-01-01

183

Hawaii hydrogen power park Hawaii Hydrogen Power Park  

E-print Network

Hawaii hydrogen power park H Hawaii Hydrogen Power Park 2003 Hydrogen & Fuel Cells Merit Review Meeting 19-22 May 2003 Maurice Kaya, PI, State of Hawaii Dr. Rick Rocheleau, PI, University of Hawaii Mitch Ewan, Project Manager, University of Hawaii #12;Hawaii hydrogen power park H Objectives

184

NASA Research Park  

NSDL National Science Digital Library

A massive addition to the NASA Ames Research Park is detailed on this site. Although the project is not scheduled to be completed until 2015, it has been in the planning stages for several years and 2003 marks the beginning of Phase 1. The 98-page NASA Ames Development Plan is available for public viewing online. The new facilities will be designed to accommodate research in "information technology, nanotechnology, biotechnology, and astrobiology." Several other news articles and formal documents about the project can be downloaded as well. The design, construction, and staffing of the new research park will reportedly generate 7,000 high-tech jobs.

185

IL15R? Recycles and Presents IL15 In trans to Neighboring Cells  

Microsoft Academic Search

We report intriguing aspects of the contribution of IL-15R? to IL-15 functions. Consistent with high-affinity interactions between IL-15 and IL-15R?, these two molecules form stable complexes on the cell surface of activated monocytes. The formation of IL-15\\/IL-15R? complexes on cell surfaces induces a trans-endosomal recycling of IL-15 leading to the persistence of surface-bound IL-15 due to the constantreappearance of IL-15

Sigrid Dubois; Jennifer Mariner; Thomas A Waldmann; Yutaka Tagaya

2002-01-01

186

Carbon Park Environmental Impact Assessment  

E-print Network

of offsetting the University's carbon footprint, promoting biodiversity and establishing easily maintained Carbon Park Environmental Impact Assessment A B.E.S.T. Project By, Adam Bond 2011 #12; Bishop's University Carbon Park

187

Geology Fieldnotes: Catoctin Mountain Park, Maryland  

NSDL National Science Digital Library

This site contains Catoctin Mountain Park information, a park map, and visitor information. A general cultural history of the park is given, from the first human inhabitants to its development into a park. Also mentioned are recreational attractions and Cunningham Falls State Park, located next to Catoctin. This park lies in the Appalachian Mountain chain.

188

Vision-based automated parking system  

Microsoft Academic Search

This paper describes an approach to overcome a situation of monitoring and managing a parking area using a vision based automated parking system. With the rapid increase of cars the need to find available parking space in the most efficient manner, to avoid traffic congestion in a parking area, is becoming a necessity in car park management. Current car park

Hamada R. H. AI-Absi; J. D. D. Devaraj; P. Sebastian; Yap Vooi Voon

2010-01-01

189

Tour of Park Geology: Shoreline Geology  

NSDL National Science Digital Library

This National Park Service (NPS) site provides links to shoreline geology fieldnotes for National Parks, Monuments, and Recreation Areas. When appropriate, fieldnotes include visitor information, geology, maps, photographs, multimedia resources, geologic research, and teacher features (lessons for teaching geology with National Park examples). Some of the parks included on this site: Acadia National Park, Everglades National Park, and Padre Island National Seashore.

190

HOURGLASS FIRE Pingree Park Vicinity  

E-print Network

HOURGLASS FIRE Pingree Park Vicinity July 1-July 7, 1994 P.N. Omi Pingree Park overview, September Pingree Park campus and Hourglass Reservoir. Summer lightning commonly occurs throughout the Rocky. Initial attack was conducted by personnel of the Arapaho-Roosevelt National Forest who arrived at the fire

191

The human ecology of parks  

Microsoft Academic Search

This paper explores a human ecological approach to the study of people and parks. A human ecological perspective is outlined, along with the key units of analysis in human ecology. A theoretical framework for treating parks as human ecosystems is developed. Several ecological processes relevant to understanding human activity within parks are discussed, including adaptation, competition, and succession. The paper

Gary E. Machlis; Donald R. Field; Fred L. Campbell

1981-01-01

192

Dry Tortugas National Park, Florida  

NSDL National Science Digital Library

This National Park Service (NPS) publication discusses Dry Tortugas National Park in Florida. This system consists of 7 small islands off the coast of Key West. The site discusses the history of this area, as well as the marine setting of the park.

193

Park Policy for the Future  

ERIC Educational Resources Information Center

Current problems within the national parks are detailed and the author determines the crux of the problems to be the inability of the National Park Service to control concessionnaires and resist pressure from natural resource developers. Changes in future national parks policy stressing more planning are advocated. (BT)

Haefele, Mina Hamilton

1976-01-01

194

FORESTS FORTHE WORLD PARK RESERVATIONS  

E-print Network

. Brochures are available at City Hall. CRANBROOK HILL GREENWAY Cranbrook Hill Greenway has over 25 km of multi-use trails that are open year round for activities such as biking, hiking and skiing. The Greenway HILL GREENWAYCRANBROOK HILL GREENWAY FORT GEORGE PARK FORT GEORGE PARK RAINBOW PARKRAINBOW PARK MOORE

Northern British Columbia, University of

195

Parking for Fans with Disabilities  

E-print Network

Parking for Fans with Disabilities UVA D3 Lot at Massie and Arlington Welcome to the dedicated parking area for fans with disabilities at Massie and Arlington, also known as the UVA D3 lot! This FREE parking area is provided for fans attending UVA football games. It is adjacent to UVA's Law School and J

Acton, Scott

196

A Communication Hub in Lagrange L1 fo r Opening the Area to Small Satellites  

NASA Astrophysics Data System (ADS)

The Lagrange points L1 and L2 of the Sun-Earth systems, both located at 1.5 million kilometres from the Earth, are the best locations for scientific missions dedicated to solar studies (L1 preferably) or astronomy and astrophysics (L2 preferably). The geometry with respect to the Sun and the Earth is very stable, as well as the space environment. The propulsion budget that is needed to reach these points, starting from an Earth orbit, is less than what is required for a geostationary orbit. The major drawback of these locations is that they are far from the Earth, which poses severe constraints on the communication system with the ground stations, mainly for receiving the scientific telemetry. Up to now, each spacecraft located at L1 or L2 (SOHO, ACE, MAP and soon HERSCHEL, PLANCK, JWST...) is quite an heavy spacecraft (thousands of kilograms) and the receiving stations on the ground are large deep space dishes. To suppress this communication bottleneck and allow these Lagrange points to be used by small satellites, it is proposed in this paper to provide wide band telemetry between small user spacecraft and ground stations through a relay satellite, which is then described. Finally, we emphasize that the adaptation of well qualified microsatellite platforms, such as the MYRIADE ones developed by CNES, can be quite simple for using them around L1, even if they have been designed for Low Earth Orbit missions.

Prado, J.-Y.; Hinglais, E.

2008-08-01

197

Augmented Lagrange Hopfield network for solving economic dispatch problem in competitive environment  

NASA Astrophysics Data System (ADS)

This paper proposes an augmented Lagrange Hopfield network (ALHN) for solving economic dispatch (ED) problem in the competitive environment. The proposed ALHN is a continuous Hopfield network with its energy function based on augmented Lagrange function for efficiently dealing with constrained optimization problems. The ALHN method can overcome the drawbacks of the conventional Hopfield network such as local optimum, long computational time, and linear constraints. The proposed method is used for solving the ED problem with two revenue models of revenue based on payment for power delivered and payment for reserve allocated. The proposed ALHN has been tested on two systems of 3 units and 10 units for the two considered revenue models. The obtained results from the proposed methods are compared to those from differential evolution (DE) and particle swarm optimization (PSO) methods. The result comparison has indicated that the proposed method is very efficient for solving the problem. Therefore, the proposed ALHN could be a favorable tool for ED problem in the competitive environment.

Vo, Dieu Ngoc; Ongsakul, Weerakorn; Nguyen, Khai Phuc

2012-11-01

198

Generalized distillability conjecture and generalizations of Cauchy-Bunyakovsky-Schwarz inequality and Lagrange identity  

E-print Network

Let rho_k, k=1,2,...,m, be the critical Werner state in a bipartite d_k by d_k quantum system, i.e., the one that separates the 1-distillable Werner states from those that are 1-indistillable. We propose a new conjecture (GDC) asserting that the tensor product of rho_k is 1-indistillable. This is much stronger than the familiar conjecture saying that a single critical Werner state is indistillable. We prove that GDC is true for arbitrary m provided that d_k is bigger than 2 for at most one index k. We reformulate GDC as an intriguing inequality for four arbitrary complex hypermatrices of type d_1 x ... x d_m. This hypermatrix inequality is just the special case n=2 of a more general conjecture (CBS conjecture) for 2n arbitrary complex hypermatrices of the same type. Surprisingly, the case n=1 turns out to be quite interesting as it provides hypermatrix generalization of the classical Lagrange identity. We also formulate the integral version of the CBS conjecture and derive the integral version of the hypermatrix Lagrange identity.

Dragomir Z. Djokovic

2010-12-22

199

On fractional Euler-Lagrange and Hamilton equations and the fractional generalization of total time derivative  

E-print Network

Fractional mechanics describes both conservative and non-conservative systems. The fractional variational principles gained importance in studying the fractional mechanics and several versions are proposed. In classical mechanics the equivalent Lagrangians play an important role because they admit the same Euler-Lagrange equations. By adding a total time derivative of a suitable function to a given classical Lagrangian or by multiplying with a constant the Lagrangian we obtain the same equations of motion. In this study, the fractional discrete Lagrangians which differs by a fractional derivative are analyzed within Riemann-Liouville fractional derivatives. As a consequence of applying this procedure the classical results are reobtained as a special case. The fractional generalization of $Fa\\grave{a}$ di Bruno formula is used in order to obtain the concrete expression of the fractional Lagrangians which differs from a given fractional Lagrangian by adding a fractional derivative. The fractional Euler-Lagrange and Hamilton equations corresponding to the obtained fractional Lagrangians are investigated and two examples are analyzed in details.

Dumitru Baleanu; Sami I. Muslih; Eqab M. Rabei

2007-08-13

200

IL-1 and IL-23 Mediate Early IL-17A Production in Pulmonary Inflammation Leading to Late Fibrosis  

E-print Network

IL-1 and IL-23 Mediate Early IL-17A Production in Pulmonary Inflammation Leading to Late Fibrosis Background: Idiopathic pulmonary fibrosis is a devastating as yet untreatable disease. We demonstrated in the establishment of pulmonary inflammation and fibrosis in mice. Methods: The contribution of IL-23 or IL-17

Paris-Sud XI, Université de

201

Parks or Prisons?  

ERIC Educational Resources Information Center

Presents a simulation activity in which students assume the role of grizzly bears in Banff National Park. Concepts such as species diversity, fitness, natural selection, habitat loss, extinction, and population dynamics are discussed. Children learn how human activities can affect the bear's reproductive success. Lists materials, instructional…

Thomson, Gareth

1998-01-01

202

Exploring Jurassic Park.  

ERIC Educational Resources Information Center

Describes several student-tested activities built around "Jurassic Park." The activities feature students engaged in role-playing scenarios, investigative research projects, journal writing and communications skills activities, cooperative learning groups, and learning experiences that make use of reading skills and mathematical knowledge. (PR)

Simmons, Patricia E.; Wiley, Clyde

1993-01-01

203

Parking & Transportation Services Sustainability &  

E-print Network

Systems ­ will allow for up-to-the-minute counts of available parking space. #12;o Real-time Travel. The University is committed to advancing the public good and improving the human condition. Overall Excellence. · 1993 Association for Commuter Transportation Merit Award ­ in recognition of travel demand management

Minnesota, University of

204

Amusement Park Physics  

NSDL National Science Digital Library

The Amusement Park Physics Website helps the user to learn more about how physics laws affect the designs of roller coasters, bumper car collisions, carousels, free fall rides, and pendulum rides. A highlight of the site is the opportunity to design a roller coaster and experiment with bumper car collisions.

Annenberg/CPB

2007-12-12

205

Parking Procedures GUIDELINES  

E-print Network

10, 2014 PURPOSE: To establish guidelines for the regulation of parking on the Washington University outside of the Clayton Garage is regulated due to more high demand for the other facilities. Clayton and a report may be forwarded to the parker's department for disposition. All vehicles on the Medical Center

Grant, Gregory

206

Summer 2012 Pingree Park  

E-print Network

& Laurel see map on other side) and fill out the Pingree Park Housing Reservation, Mon-Fri from 9:00 am transfer students Jan 30 - Feb 3 - Only current Sophomores Feb 6 - 17 - Open enrollment (space available-50705] Prerequisites: BZ 110 & 111 or BZ 120 or LIFE 103; MATH 118 (LAND 220/LIFE 220, LIFE 320, F 210, and/or BZ 223

207

KALELE ROAD Parking Office  

E-print Network

Hall Keller Hall Edmondson Hall Gateway House Orvis Auditorium Music Building Complex Speech Pathology Environ. Health Transportation Services Landscaping No Vehicle Access No Public Vehicle Access No Public Kiosk Bachman Kiosk Entrance Kiosk Gym 1 Gym 2 UH Parking Access St. Francis School University Health

208

Industrial parks as ecosystems  

Microsoft Academic Search

Industrial ecology and metabolism provide a conceptual framework for the transformation of our production and consumption system into a transition toward sustainable development. This is consistent with the expressed views of a wide range of industrial and business associations. Burnside Industrial Park in Dartmouth, Nova Scotia, provides an opportunity to investigate the application of the concept to small businesses. The

R. Côté; J. Hall

1995-01-01

209

Yellowstone National Park  

NSDL National Science Digital Library

Yellowstone National Park was established on March 1, 1872, as the first national park in the world. The overwhelming and unique beauty found in this natural wonder is truly difficult to describe.This Topic In Depth begin with the excellent National Park Service's (1) official Yellowstone Web Site, which contains the park's history, virtual field trips, park information, visitor guides, web cams, kids pages, and more. The next site offered by EarthTalk Studios is called Yellowstone Geographic. This extensive and graphically reliant site contains superb interactive activities related to the park and comes close to its goal of being "the best Yellowstone Web Site on the planet." The third site from UnMuseum.org called Weird Geology: Geysers explores the workings of Yellowstone's famous geysers with descriptions, photographs, illustrations, and a movie of an eruption. The next site from Exploratorium is a learning activity called Geyser: Cyclic Hot Water Fountain. With the help of their teacher, students build a working model of a geyser from common chemical equipment. From the University of Michigan, Meg Streepey's Geysers and the Earth's Plumbing Systems Web Site describes (for more advanced students) how geysers work, including how to analyze their thermal and hydrologic regimes. Another research site, from the University of Utah's College of Mines and Earth Sciences, is the GPS Surveys of the Yellowstone Hotspot and the Wasatch Fault, Utah. Objectives of the study are "to measure and understand the spatial and temporal variations of the crustal deformation produced by the interaction between lithospheric plate motion and the asthenospheric hotspot." The last two sites are from the USGS, the first of which is the Yellowstone River Basin National Water-Quality Assessment Program site. It contains a project description, available data, and other relevant information. The last site, Yellowstone Volcano Observatory, is a facility that is designed for observing volcanic and earthquake activity in the park. This site also contains a project description, volcanic data, maps, descriptions of volcanic rock, a frequently asked questions link, and more.

Brieske, Joel A.

2002-01-01

210

Optimized Expression of IL-12 Cytokine Family  

Cancer.gov

The IL-12 family of cytokines (IL-12, IL-23, and IL-27) plays a role in infection, inflammation and autoimmune diseases. IL-12 is produced by macrophages and dendritic cells in response to certain bacterial and parasitic infections and is a powerful inducer of IFN-gamma production.

211

USGS: Geology in the Parks  

NSDL National Science Digital Library

The US Geological Survey Geology in the Parks Web site is a cooperative project of the USGS Western Earth Surface Processes Team and the National Park Service. This extensive site covers geologic maps, plate tectonics, rocks and minerals, geologic time, US geologic provinces, park geology of the Mojave, Sunset Crater, Lake Mead, North Cascades, Death Valley, Yosemite National Park, and much more. Descriptions, graphics, photographs, and animations all contribute to this informative and interesting Web site making it a one stop, all encompassing, resource for everything geology and US national park related.

212

Tour of Park Geology: Fossils  

NSDL National Science Digital Library

This National Park Service Geology site provides links to tours of individual National Parks, Monuments, and Recreation Areas that contain fossils. Where appropriate, for each park, links are provided to park geology, maps, photographs, geologic research, related links, visitor information, multimedia resources, and teacher features (resources for teaching geology with National Park examples). The list includes places such as the Grand Canyon, Dinosaur National Monument, Yellowstone, and Death Valley, along with less well-known areas such as the John Day Fossil Beds National Monument in Oregon.

213

Parking: an effective strategy described.  

PubMed

A hospital car park needs to balance the demands of patients, visitors, and staff, without, for example, compromising emergency vehicles' access to the Accident & Emergency Department. However, with car ownership on the rise, the half a million car parking spaces across all Trust sites in England may not be enough to meet future demand. Philip Herring, managing director of VINCI Park UK, which designs, finances, builds, and operates, car parks for a variety of sectors, argues that having in place an effective strategy for future parking is vital to meet the growing needs of patients, visitors, and staff, as well as budgetary and environmental commitments. PMID:24397228

Herring, Philip

2013-11-01

214

Chapter 8 Baseline water chemistry, nitrate concentrations, and aquifer sensitivity of glacial sequences in LaGrange County, Indiana  

Microsoft Academic Search

A project was initiated to evaluate the chemistry and relative age of groundwater in glacial sequences in LaGrange County in northeastern Indiana in 2002. The intent was to acquire a baseline dataset for selected ions, trace elements, and isotopes in water from 50 wells. In 2003, samples were collected from 18 additional wells that produce groundwater known to have high

Nancy R. Hasenmueller; Tracy D. Branam

2007-01-01

215

Application of the Lagrange-Souriau form method to the case of source-free electromagnetic field  

E-print Network

The recent method of the description of classical fields in terms of Lagrange-Souriau form is applied to the case of source-free electromagnetic field in order to check its computational capabilities. The relevant calculations are represented in all details and yield a useful data for comparisons of the method with more usual approaches in this simple and transparent case.

S. Tertychniy

1993-12-29

216

A suggested trajectory for a Venus-sun, earth-sun Lagrange points mission, Vela  

NASA Technical Reports Server (NTRS)

The possibility is suggested of investigating the existence of small, as-yet undiscovered, asteroids orbiting in the solar system near the earth-sun or Venus-sun stable Lagrange points by means of a spacecraft which traverses these regions. The type of trajectory suggested lies in the ecliptic plane and has a period of 5/6 years and a perihelion at the Venus orbital distance. The regions in which stable orbits associated with the earth and with Venus may lie are estimated to be a thin and tadpole-shaped area extending from 35 deg to 100 deg from the planet. Crossings of the regions by the trajectory are described, and the requirements for detecting the presence of 1 km sized asteroids are presented and shown to be attainable.

Bender, D. F.

1979-01-01

217

On a Lagrange-Hamilton formalism describing position and momentum uncertainties  

NASA Technical Reports Server (NTRS)

According to Heisenberg's uncertainty relation, in quantum mechanics it is not possible to determine, simultaneously, exact values for the position and the momentum of a material system. Calculating the mean value of the Hamiltonian operator with the aid of exact analytic Gaussian wave packet solutions, these uncertainties cause an energy contribution additional to the classical energy of the system. For the harmonic oscillator, e.g., this nonclassical energy represents the ground state energy. It will be shown that this additional energy contribution can be considered as a Hamiltonian function, if it is written in appropriate variables. With the help of the usual Lagrange-Hamilton formalism known from classical particle mechanics, but now considering this new Hamiltonian function, it is possible to obtain the equations of motion for position and momentum uncertainties.

Schuch, Dieter

1993-01-01

218

Augmented lagrange hopfield network for economic dispatch with multiple fuel options  

SciTech Connect

This paper proposes an augmented Lagrange Hopfield network (ALHN) for solving economic dispatch (ED) problem with multiple fuel options. The proposed ALHN method is a continuous Hopfield neural network with its energy function based on augmented Lagrangian function. The advantages of ALHN over the conventional Hopfield neural network are easier use, more general applications, faster convergence, better optimal solution, and larger scale of problem implementation. The method solves the problem by directly searching the most suitable fuel among the available fuels of each unit and finding the optimal solution for the problem based on minimization of the energy function of the continuous Hopfield neural network. The proposed method is tested on systems up to 100 units and the obtained results are compared to those from other methods in the literature. The results have shown that the proposed method is efficient for solving the ED problem with multiple fuel options and favorable for implementation in large scale problems.

Dieu, Vo Ngoc; Ongsakul, Weerakorn; Polprasert, Jirawadee [Energy Field of Study, School of Environment, Resources and Development, Asian Institute of Technology, Klongluang, Pathumthani (Thailand)

2011-06-20

219

Augmented Lagrange Hopfield Network for Economic Dispatch with Multiple Fuel Options  

NASA Astrophysics Data System (ADS)

This paper proposes an augmented Lagrange Hopfield network (ALHN) for solving economic dispatch (ED) problem with multiple fuel options. The proposed ALHN method is a continuous Hopfield neural network with its energy function based on augmented Lagrangian function. The advantages of ALHN over the conventional Hopfield neural network are easier use, more general applications, faster convergence, better optimal solution, and larger scale of problem implementation. The method solves the problem by directly searching the most suitable fuel among the available fuels of each unit and finding the optimal solution for the problem based on minimization of the energy function of the continuous Hopfield neural network. The proposed method is tested on systems up to 100 units and the obtained results are compared to those from other methods in the literature. The results have shown that the proposed method is efficient for solving the ED problem with multiple fuel options and favorable for implementation in large scale problems.

Dieu, Vo Ngoc; Ongsakul, Weerakorn; Polprasert, Jirawadee

2011-06-01

220

Augmented Lagrange Based on Modified Covariance Matching Criterion Method for DOA Estimation in Compressed Sensing  

PubMed Central

A novel direction of arrival (DOA) estimation method in compressed sensing (CS) is presented, in which DOA estimation is considered as the joint sparse recovery from multiple measurement vectors (MMV). The proposed method is obtained by minimizing the modified-based covariance matching criterion, which is acquired by adding penalties according to the regularization method. This minimization problem is shown to be a semidefinite program (SDP) and transformed into a constrained quadratic programming problem for reducing computational complexity which can be solved by the augmented Lagrange method. The proposed method can significantly improve the performance especially in the scenarios with low signal to noise ratio (SNR), small number of snapshots, and closely spaced correlated sources. In addition, the Cramér-Rao bound (CRB) of the proposed method is developed and the performance guarantee is given according to a version of the restricted isometry property (RIP). The effectiveness and satisfactory performance of the proposed method are illustrated by simulation results. PMID:24678272

Si, Weijian; Qu, Xinggen; Liu, Lutao

2014-01-01

221

Nuclear critical charge for two-electron ion in Lagrange mesh method  

E-print Network

The Schroedinger equation for two electrons in the field of a charged fixed center $Z$ is solved with the Lagrange mesh method for charges close to the critical charge $Z_{cr}$. We confirm the value of the nuclear critical charge $Z_{cr}$ recently calculated in Estienne et al. {\\em Phys. Rev. Lett. \\bf 112}, 173001 (2014) to 11 decimal digits using an inhomogeneous (non-uniform) three-dimensional lattice of size $70 \\times 70 \\times 20$. We show that the ground state energy for H$^-$ is accurate to 14 decimals on the lattice $50 \\times 50 \\times 40$ in comparison with the highly accurate result by Nakashima-Nakatsuji, {\\it J. Chem. Phys. \\bf 127}, 224104 (2007).

H. Olivares Pilón; A. V. Turbiner

2014-12-16

222

2012-13 UT Basketball Parking Information Campus Parking: On weekdays, the majority of parking on campus requires a basketball  

E-print Network

2012-13 UT Basketball Parking Information Campus Parking: On weekdays, the majority of parking on campus requires a basketball parking permit beginning at 4:00pm.* On weekends, the same is true but times DURING WEEKDAY BASKETBALL GAMES: The following parking areas will be designated for students with a valid

Tennessee, University of

223

Rocking the Parks: Geological Stories of the National Parks  

NSDL National Science Digital Library

Rocking the Parks: Geological Stories of the National Parks is an online book by Richard B. Alley of Penn State Universities e-Education Institute. The site contains thirty chapters that relate geology and the US National Parks, such as plate tectonics and Death Valley, volcanoes and Yellowstone, and glaciers and Yosemite. Each Adobe Acrobat (.pdf) file can be downloaded and viewed free of charge.

Alley, Richard B.

224

Mesoscale Simulations of Particulate Flows with Parallel Distributed Lagrange Multiplier Technique  

SciTech Connect

Fluid particulate flows are common phenomena in nature and industry. Modeling of such flows at micro and macro levels as well establishing relationships between these approaches are needed to understand properties of the particulate matter. We propose a computational technique based on the direct numerical simulation of the particulate flows. The numerical method is based on the distributed Lagrange multiplier technique following the ideas of Glowinski et al. (1999). Each particle is explicitly resolved on an Eulerian grid as a separate domain, using solid volume fractions. The fluid equations are solved through the entire computational domain, however, Lagrange multiplier constrains are applied inside the particle domain such that the fluid within any volume associated with a solid particle moves as an incompressible rigid body. Mutual forces for the fluid-particle interactions are internal to the system. Particles interact with the fluid via fluid dynamic equations, resulting in implicit fluid-rigid-body coupling relations that produce realistic fluid flow around the particles (i.e., no-slip boundary conditions). The particle-particle interactions are implemented using explicit force-displacement interactions for frictional inelastic particles similar to the DEM method of Cundall et al. (1979) with some modifications using a volume of an overlapping region as an input to the contact forces. The method is flexible enough to handle arbitrary particle shapes and size distributions. A parallel implementation of the method is based on the SAMRAI (Structured Adaptive Mesh Refinement Application Infrastructure) library, which allows handling of large amounts of rigid particles and enables local grid refinement. Accuracy and convergence of the presented method has been tested against known solutions for a falling sphere as well as by examining fluid flows through stationary particle beds (periodic and cubic packing). To evaluate code performance and validate particle contact physics algorithm, we performed simulations of a representative experiment conducted at the University of California at Berkley for pebble flow through a narrow opening.

Kanarska, Y

2010-03-24

225

77 FR 53826 - Special Regulations; Areas of the National Park System, Yellowstone National Park  

Federal Register 2010, 2011, 2012, 2013, 2014

...DEPARTMENT OF THE INTERIOR National Park Service [NPS-YELL-10569; 2310-0070-422...1024-AE10 Special Regulations; Areas of the National Park System, Yellowstone National Park AGENCY: National Park Service,...

2012-09-04

226

77 FR 73919 - Special Regulations; Areas of the National Park System, Yellowstone National Park  

Federal Register 2010, 2011, 2012, 2013, 2014

...DEPARTMENT OF THE INTERIOR National Park Service [NPS-YELL-11802; PPWONRADE2...1024-AE10 Special Regulations; Areas of the National Park System, Yellowstone National Park AGENCY: National Park Service,...

2012-12-12

227

Interleukin-4 (IL-4) Pathway  

NSDL National Science Digital Library

Interleukin-4 (IL-4) is a cytokine produced by TH2 type helper T cells and by mast cells, basophils, and eosinophils. This cytokine can elicit many responses, some of which are associated with allergy and asthma. Studies with long-term cell lines and primary cells have revealed differences in the signaling between these two experimental systems. Understanding these differences is important because therapeutic strategies targeting IL-4 and its signaling pathways are currently being tested to treat allergy and asthma.

Ann Kelly-Welch (University of Maryland and Stewart Greenebaum Cancer Center; Program in Oncology at Marlene and Department of Microbiology and Immunology REV)

2005-07-19

228

UNIVERSITY of HOUSTON Parking and Transportation Services  

E-print Network

UNIVERSITY of HOUSTON Parking and Transportation Services Proposed FY14 and FY15 Parking Rates March ­ April Auxiliary Services Parking and Transportation Shared Governance Committee - Transportation of University of Houston parking and transportation programs. 2. To improve and maintain parking infrastructure

Bittner, Eric R.

229

National Park Service Exotic Plant Management Teams  

E-print Network

National Park Service Exotic Plant Management Teams Tony Pernas National Park Service Southeast Region Office National Park Service Biological Resource Management Division #12;· Protect native · Host Park; · Team Composition; · Steering Committees. #12;National Park Service Units in Florida ( 2

Watson, Craig A.

230

Intelligent Parking Negotiation Based on Agent Technology  

Microsoft Academic Search

In order to solve the parking problems in the metropolises, a new approach integrating active pattern for parking guidance information system composed of parks, cars and parking information service center and traffic management center is proposed. A multi-phase navigation method based on a two-layer traffic map is employed for parking routes negotiation and guidance. The system is implemented based on

Li Yang; Ma Rongguo; Wang Longfei

2009-01-01

231

Tour of Park Geology: Human Use Sites  

NSDL National Science Digital Library

This National Park Service (NPS) site provides links to geolgy field notes about National Parks, National Monuments, and National Recreation Areas having to do with geology and human use (such as mining). Information includes geology, photographs, multimedia tools, park maps, visitor information, geologic research, and additional links. Parks covered include Klondike Gold Rush National Historic Park, Alibates Flint Quarries National Monument, and more.

232

Public Responses to National Park Environmental Policy  

Microsoft Academic Search

The behavioral responses of urban and semirural residents to a newly initiated national park environmental policy are investigated. The policy broadly involves the reduction of service facilities within the park and a concomitant emphasis on the park's natural environment. It is disclosed that (1) awareness of the park policy and (2) overt patronage of the park are related to relative

Geoffrey C. Smith; David Alderdice

1979-01-01

233

Tour of Park Geology: River Systems  

NSDL National Science Digital Library

This site provides links to National Parks, Monuments, Preserves, Rivers, and Recreation Areas with fluvial landforms. Park links provide maps, photographs, geologic and historical information, and teacher features (links for teaching tools). Parks in this category include Big Bend National Park, Canyonlands National Park, Buffalo National River, and more.

234

Terrein / car park: Inleveren bij / submit to  

E-print Network

Procedure: Terrein / car park: Inleveren bij / submit to: Info: Vul a.u.b. uw gegevens in / please terrein, voor de duur van: Requests access to the car park(s) mentioned above for the period of voorbehoud kan van toepassing zijn. You can request access rights for the local car park(s) on one campus

Galis, Frietson

235

Geology of the National Parks  

NSDL National Science Digital Library

This resource provides information about United States Geological Survey (USGS) resources and activities associated with National Parks. Users can choose from a selection of links that access items on park geology, virtual trips, research projects, and general topics such as plate tectonics, rocks and minerals, shorelines, glaciers, and many more. Links to geologic information for individual parks are arranged by alphabet, by state, or by geologic province.

236

National Parks WebQuest  

NSDL National Science Digital Library

This web-based activity challenges students to use a variety of internet resources to learn about several dimensions of national parks. Each student's research assignment focuses on one component of a park, such as its history, biology, geology, or tourist appeal. Students must keep track of important points and their references. Once research is complete, students come together and teach each other about their specific research domain, culminating in a holistic understanding of the park features.

Mrs. Phillip

237

Geology of Badlands National Park  

NSDL National Science Digital Library

This page is an introduction to the 75 million years of accumulation and intermittent periods of erosion that has resulted in the Badlands National Park. The history of the Oglicene beds of the Park, one of the world's richest vertebrate fossil sites, is also described. A downloadable PDF that describes the erosion that is responsible for the geology of the Park in more detail is linked to the site.

National Park Service (NPS)

238

Soluble IL7R? potentiates IL-7 bioactivity and promotes autoimmunity  

PubMed Central

Human soluble interleukin-7 receptor (sIL7R)? circulates in high molar excess compared with IL-7, but its biology remains unclear. We demonstrate that sIL7R? has moderate affinity for IL-7 but does not bind thymic stromal lymphopoietin. Functionally, sIL7R? competes with cell-associated IL-7 receptor to diminish excessive IL-7 consumption and, thus, enhances the bioactivity of IL-7 when the cytokine is limited, as it is presumed to be in vivo. IL-7 signaling in the presence of sIL7R? also diminishes expression of CD95 and suppressor of cytokine signaling 1, both regulatory molecules. Murine models confirm diminished consumption of IL-7 in the presence of sIL7R? and also demonstrate a potentiating effect of sIL7R? on IL-7–mediated homeostatic expansion and experimental autoimmune encephalomyelitis exacerbation. In multiple sclerosis and several other autoimmune diseases, IL7R genotype influences susceptibility. We measured increased sIL7R? levels, as well as increased IL-7 levels, in multiple sclerosis patients with the predisposing IL7R genotype, consistent with diminished IL-7 consumption in vivo. This work demonstrates that sIL7R? potentiates IL-7 bioactivity and provides a basis to explain the increased risk of autoimmunity observed in individuals with genotype-induced elevations of sIL7R?. PMID:23610432

Lundström, Wangko; Highfill, Steven; Walsh, Scott T. R.; Beq, Stephanie; Morse, Elizabeth; Kockum, Ingrid; Alfredsson, Lars; Olsson, Tomas; Hillert, Jan; Mackall, Crystal L.

2013-01-01

239

Visits to national parks: Effects of park characteristics and spatial demand  

Microsoft Academic Search

Understanding the relationship between the number of visits to national parks and their characteristics is crucial for park planning and management. Visitation has a key role in existing national parks, but also in assessing the social and economic impacts of new parks. This study examined how the natural characteristics of a park, the recreation facilities and services inside a park

Marjo Neuvonen; Eija Pouta; Jenni Puustinen; Tuija Sievänen

2010-01-01

240

A low diffusive Lagrange-remap scheme for the simulation of violent ai-water free-surface flows  

NASA Astrophysics Data System (ADS)

In 2002, Després and Lagoutičre [17] proposed a low-diffusive advection scheme for pure transport equation problems, which is particularly accurate for step-shaped solutions, and thus suited for interface tracking procedure by a color function. This has been extended by Kokh and Lagoutičre [28] in the context of compressible multifluid flows using a five-equation model. In this paper, we explore a simplified variant approach for gas-liquid three-equation models. The Eulerian numerical scheme has two ingredients: a robust remapped Lagrange solver for the solution of the volume-averaged equations, and a low diffusive compressive scheme for the advection of the gas mass fraction. Numerical experiments show the performance of the computational approach on various flow reference problems: dam break, sloshing of a tank filled with water, wate-water impact and finally a case of Rayleigh-Taylor instability. One of the advantages of the present interface capturing solver is its natural implementation on parallel processors or computers. wave formation and wave breaking; wall wave impacts, local pressure peaks and pressure loadings; formation of air pockets; ejection, fragmentation of liquid droplets; Archimedes buoyancy effect with rising of bubbles and fall of droplets; effects of gas compressibility inducing a gas-to-liquid response by a pressure wave, etc. In this paper, we consider immiscible gas-liquid two-phase flow problems. The strong ratio of mass density between gas and liquid (typically 1:1000) is known to be a source of numerical stiffness and numerical instability. Therefore robust computational approaches supporting high density ratio have to be considered. Among the family of conservative Finite Volume methods (FVM), the Lagrange-remapped solvers (see e.g. [42,45,6,4,25,2]) provide both robustness and stability with achievement of mathematical properties of positiveness and entropy compatibility.Lagrange-remap numerical schemes (also referred to as Eule-Lagrange schemes) are a particular family of Eulerian FVM where, at each time step, the equations are solved according to a Lagrangian evolution with a mesh that is convected by the flow itself, then the "Lagrange solutions" are remapped on the initial mesh into a conservative way by estimating both fluxed mass and momentum. Because of the Lagrangian step of these methods, code coupling or coupling of different physics is made easier against conventional FV methods. Moreover, the Lagrangian description is very practical for multi-material flows of multi-phase flows because we are a natural control of the fluxed quantities material-by-material. Lagrange and Lagrange-remap solvers still know strong developments today with major contributions as e.g. energy-preserving compatible schemes for staggered methods [11], collocated variables and cell-centered entropy-satisfying schemes, see [18,32,12].In this paper, we rather consider a simpler staggered Lagrange-remap solver with a direction-by-direction remapping. More precisely, the 2D multidimensional Lagrange step (operator Lxy?t) completely solves the fluid equations while an operator splitting alternating direction (AD) for the projection (operators Rx and Ry respectively) is used to interpolate on the reference Cartesian Eulerian grid into a conservative manner, involving convective flux balances. Symmetrized operator splitting can be used to ensure second order accuracy. Both linear and nonlinear numerical stabilities are ensured by the use of standard pseudo-viscosity (viscous pressure) terms, detailed into Appendix B at the end of this paper. Actually, we use this simple Euler solver because of its simplicity of code implementation and because it can be vectorized/parallelized into a natural manner. Moreover, the aim of this paper is not about the hydrodynamics solver: the article mostly focuses on numerical antidiffusive methods for interface capturing, as part of a global multifluid hydrodynamics solver. At the present time, the antidiffusive approaches assume a direction-by-direction remapping whic

Bernard-Champmartin, Aude; De Vuyst, Florian

2014-10-01

241

Bleomycin and IL-1?–mediated pulmonary fibrosis is IL-17A dependent  

PubMed Central

Idiopathic pulmonary fibrosis (IPF) is a destructive inflammatory disease with limited therapeutic options. To better understand the inflammatory responses that precede and concur with collagen deposition, we used three models of pulmonary fibrosis and identify a critical mechanistic role for IL-17A. After exposure to bleomycin (BLM), but not Schistosoma mansoni eggs, IL-17A produced by CD4+ and ??+ T cells induced significant neutrophilia and pulmonary fibrosis. Studies conducted with C57BL/6 il17a?/? mice confirmed an essential role for IL-17A. Mechanistically, using ifn??/?, il10?/?, il10?/?il12p40?/?, and il10?/?il17a?/? mice and TGF-? blockade, we demonstrate that IL-17A–driven fibrosis is suppressed by IL-10 and facilitated by IFN-? and IL-12/23p40. BLM-induced IL-17A production was also TGF-? dependent, and recombinant IL-17A–mediated fibrosis required TGF-?, suggesting cooperative roles for IL-17A and TGF-? in the development of fibrosis. Finally, we show that fibrosis induced by IL-1?, which mimics BLM-induced fibrosis, is also highly dependent on IL-17A. IL-17A and IL-1? were also increased in the bronchoalveolar lavage fluid of patients with IPF. Together, these studies identify a critical role for IL-17A in fibrosis, illustrating the potential utility of targeting IL-17A in the treatment of drug and inflammation-induced fibrosis. PMID:20176803

Wilson, Mark S.; Madala, Satish K.; Ramalingam, Thirumalai R.; Gochuico, Bernadette R.; Rosas, Ivan O.; Cheever, Allen W.

2010-01-01

242

T PARK: AMBIENT INTELLIGENCE FOR SECURITY IN PUBLIC PARKS  

Microsoft Academic Search

In this paper, we present joint research activities in com- puter vision and sensor networks for a distributed surveil- lance of urban parks. Distributed visual surveillance of ur- ban environments is one of the most interesting scenario in Ambient Intelligence; in addition, the automated monitor- ing of public parks, often crowded by children and adults, is still a very difficult

Luca Benini; Elisabetta Farella

243

Garage Parking n Visitors may park in garages  

E-print Network

and students and do not require a permit Garage Parking Rates* 0 - 30 minutes No Charge 30 minutes - 1 hour $ 3 All spaces on campus require a valid UT Permit or the display of a paid parking receipt n All garages Computational Engineering & Sciences...B2 ADH Almetris Duren Residence Hall ..........A1 AFP Athletics Field

Raizen, Mark G.

244

MOLECULAR AND FUNCTIONAL CHARACTERIZATIONS OF IL-17  

Technology Transfer Automated Retrieval System (TEKTRAN)

In mammals, the IL-17 family of cytokines (IL-17A-F) has a very distinct expression pattern and a different biological function. IL-17 is mainly secreted by activated CD4+ T cells and has been implicated in autoimmune and inflammatory diseases. IL-17 has been shown to exert an important role in host...

245

Designing for ecology : the ecological park  

E-print Network

This thesis aims to define a) what an ecological park is, and b) whether it is a new model in park design. Reference to the literature on landscape ecology is used to analyze the natural ecological merit of these parks, ...

Power, Andres M

2006-01-01

246

Salute to the National Park Service  

ERIC Educational Resources Information Center

Current National Parks Service's design policy is summarized and the manner in which this policy produces national park transportation, planning, visitor center siting, architecture, preservation, and exhibits, is detailed. Organizations lobbying for better parks are listed. (BT)

Carpenter, Edward K.

1976-01-01

247

Characterization and favorable in vivo properties of heterodimeric soluble IL-15·IL-15R? cytokine compared to IL-15 monomer.  

PubMed

Interleukin-15 (IL-15), a 114-amino acid cytokine related to IL-2, regulates immune homeostasis and the fate of many lymphocyte subsets. We reported that, in the blood of mice and humans, IL-15 is present as a heterodimer associated with soluble IL-15 receptor ? (sIL-15R?). Here, we show efficient production of this noncovalently linked but stable heterodimer in clonal human HEK293 cells and release of the processed IL-15·sIL-15R? heterodimer in the medium. Purification of the IL-15 and sIL-15R? polypeptides allowed identification of the proteolytic cleavage site of IL-15R? and characterization of multiple glycosylation sites. Administration of the IL-15·sIL-15R? heterodimer reconstituted from purified subunits resulted in sustained plasma IL-15 levels and in robust expansion of NK and T cells in mice, demonstrating pharmacokinetics and in vivo bioactivity superior to single chain IL-15. These identified properties of heterodimeric IL-15 provide a strong rationale for the evaluation of this molecule for clinical applications. PMID:23649624

Chertova, Elena; Bergamaschi, Cristina; Chertov, Oleg; Sowder, Raymond; Bear, Jenifer; Roser, James D; Beach, Rachel K; Lifson, Jeffrey D; Felber, Barbara K; Pavlakis, George N

2013-06-21

248

Production of Mice Deficient in Genes for Interleukin (IL)-1 a , IL1 b , IL1 a \\/ b , and IL1 Receptor Antagonist Shows that IL1 b Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion  

Microsoft Academic Search

Summary Interleukin (IL)-1 is a major mediator of inflammation and exerts pleiotropic effects on the neuro-immuno-endocrine system. To elucidate pathophysiological roles of IL-1, we have first produced IL-1 a \\/ b doubly deficient (KO) mice together with mice deficient in either the IL-1 a , IL-1 b , or IL-1 receptor antagonist (IL-1ra) genes. These mice were born healthy, and

Reiko Horai; Masahide Asano; Katsuko Sudo; Hirotaka Kanuka; Masatoshi Suzuki; Masugi Nishihara; Michio Takahashi; Yoichiro Iwakura

249

National Park Service: Nature and Science  

NSDL National Science Digital Library

This is the nature and science portal for the National Park Service. Visitors can access information on air quality in the national parks, wildlife health and management, invasive species, threatened and endangered species, and others. Geologic materials include park geology tours, minerals management in and adjacent to parks, disturbed lands restoration, and others. Water-related materials include wetlands in parks, fisheries, water quality and flow issues, and others. Additional materials include park soundscapes, laws and regulations, publications, and news articles.

250

Geology Fieldnotes: Petrified Forest National Park, Arizona  

NSDL National Science Digital Library

Petrified Forest National Park was established to preserve large deposits of petrified wood and to prevent removal of the wood by the public. Site featues include park geology information, maps, photographs, related links, visitor information, multimedia resources, and resources for teaching geology with National Park examples. The park geology section discusses the park's geologic history, structural geology, petrified wood, and dinosaur fossils. The maps section includes a map of the park itself and the surrounding area.

251

Role of IL-38 and Its Related Cytokines in Inflammation  

PubMed Central

Interleukin- (IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22. IL-38 also inhibits the production of IL-8 induced by IL-36?, thus inhibiting inflammatory responses. IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses. The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future. PMID:25873772

Yuan, Xianli; Peng, Xiao; Li, Yan; Li, Mingcai

2015-01-01

252

Biology of IL-36 cytokines and their role in disease.  

PubMed

IL-36?, IL-36?, IL-36?, and IL-36Ra, collectively called IL-36 cytokines, are part of the IL-1 family. IL-36?, IL-36?, and IL-36? are IL-36 receptor (IL-36R) agonists, while IL-36Ra is a receptor antagonist that blocks the activation of IL-36R signaling. IL-36 cytokines require processing in order to become fully active, however the protease(s) responsible for this are currently not known. The IL-36 receptor pathway activates dendritic cells and plays a role in polarizing T-helper responses. The skin is the predominant site where IL-36 cytokines are expressed and several reports have established that they play a significant role in the pathogenesis of skin diseases. In this review the discovery and biological function of the cytokines IL-36?, IL-36?, IL-36? and IL-36Ra will be discussed, and their role in the pathogenesis of a wide variety of diseases. PMID:24355486

Gresnigt, Mark S; van de Veerdonk, Frank L

2013-12-15

253

IL-10 Implications in Psoriasis  

PubMed Central

Interleukin (IL)-10 is a pluripotent cytokine with effects on numerous cell populations, in particular circulating and resident immune cells as well as epithelial cells. With its potent immunoregulatory capacities, its main biological function seems to be the limitation and termination of inflammatory responses. Hence, its low level expression found in psoriasis may have pathophysiological relevance to this immune disease. Remarkably, the induction of IL-10 expression was found by conventional antipsoriatic therapies, supporting the hypothesis that it may be a key cytokine in psoriasis. Furthermore, the first use in clinical trials in patients with established psoriasis showed that it had moderate antipsoriatic effects and was well tolerated. Moreover, long-term application in psoriatic patients in remission showed that it decreases the incidence of relapse and prolongs the disease free interval. The IL-10 antipsoriatic activity is suggested to be due to the effects on different cell populations, including antigen presenting cells and T-cells (type 1 / type 2 balance shift), but not through direct effects on keratinocytes. In conclusion, IL-10 seems to have major clinical and therapeutic implications in psoriasis. Further multicenter, placebo-controlled, double blind trials are required to be an established antipsoriatic therapy. We can come to the conclusion that IL-10 genetic polymorphism and expression is potentially a key immune marker in psoriasis. PMID:21475472

Al-Robaee, Ahmad A.; Al-Zolibani, Abdullateef A.; Al-Shobili, Hani A.; Kazamel, Amira; Settin, Ahmad

2008-01-01

254

MIDDLE PARK Conservation Action Plan  

E-print Network

. 2009). Both species are listed as endangered under the Endangered Species Act by US Fish and WildlifeMIDDLE PARK Conservation Action Plan 2011 Update Plant Species of Focus: Kremmling milkvetch .......................................................................................................................... 15 Attachment 1. Additional key species and plant communities in the Middle Park area .... 16

255

Amusement park injuries and deaths  

Microsoft Academic Search

Media coverage of amusement park injuries has increased over the past several years, raising concern that amusement rides may be dangerous. Amusement park fatalities and increases in reported injuries have prompted proposed legislation to regulate the industry. Since 1979, the medical literature has published reports of 4 subdural hematomas, 4 internal carotid artery dissections, 2 vertebral artery dissections, 2 subarachnoid

Robert J. Braksiek; David J. Roberts

2002-01-01

256

An Amusement Park Physics Competition  

ERIC Educational Resources Information Center

Amusement park physics is a popular way to reinforce physics concepts and to motivate physics learners. This article describes a novel physics competition where students use simple tools to take amusement park ride measurements and use the data to answer challenging exam questions. Research into the impact of participating in the competition…

Moll, Rachel F.

2010-01-01

257

Hospital Specialty Clinics Park Center  

E-print Network

(MCW) A. Health Research Center B. MCW Medical Education Building C. MCW Basic Science Building D. MACCDrive Research Park Center Campus Map for Medical College of Wisconsin (MCW), Milwaukee Regional Medical Center Center Mental Health Complex Curative Blood Center Research Institute Research Park Center Fitness Center

258

Hospital Specialty Clinics Park Center  

E-print Network

* 18* 13 19* 1. Medical College of Wisconsin (MCW) A. Health Research Center B. MCW Medical Education's Hospital Offices) 15. Research Park Center 16. Froedtert & the Medical College of Wisconsin Sargeant Health Research Park (left) is shown reduced in scale compared to the Milwaukee Regional Medical Center (above

259

An Intelligent Parking Information System  

Microsoft Academic Search

With the increasing number of vehicle on the road, parking has become a huge problem for people in urban area such as Kuala Lumpur. The lack of information displayed while parking is taking place has frustrated many consumers mainly in shopping complexes and office buildings. One of the reasons is that the consumer has to take more time in searching

Yamani Idna Idris; Emran Mohd

260

Parking Services Rules and Regulations  

E-print Network

.4 Liability 3 2 Two Wheeled Vehicles 4 2.1 Motorcycles / Mopeds / Scooters 4 3 Parking Permits 4 3.1 General Immobilization 13 4.17 Suspension of Parking Privileges 13 5 Appeals 13 5.1 Submission of Appeals 13 5.2 Appeal. Exceptions to regulations, temporary regulations and enforcement suspensions are valid only for when and how

Moore, Paul A.

261

Can Twitter save Bletchley Park?  

Microsoft Academic Search

Bletchley Park is the historic site of secret British codebreaking activities during World War II and birthplace of the modern computer. The work carried out there is said to have shortened WWII by two years, saving possibly 22 million lives. The Park is now a museum, with a 26 acre site, many exhibitions and working rebuilds of machines such as

Sue Black; Jonathan P. Bowen; Kelsey Griffin

2010-01-01

262

Microbiology in Yellowstone National Park  

NSDL National Science Digital Library

This site describes how Yellowstone National Park is a focal point for cutting-edge microbiology research and how it provides a valuable setting for outreach education. Topics include questions for park officials, extremophiles, microbe diversity and evolution, educational outreach, and suggested reading.

Ward David

263

Nevada Division of State Parks  

NSDL National Science Digital Library

Based in Carson City, the Nevada Division of State Parks helps to preserve and promote notable parts of the Nevada natural and cultural environment. One of the goals of their website is to provide visitors with "an introduction to the other side of Nevada, the side that is wild scenic and full of western history." First-time visitors may wish to click on the "State parks map" area to learn more about the location of the state parks, and the interactive map also includes direct links to each site. Scholars and students of park management will want to click on over to the "Park General and Resource Management Plans" area. Here they can learn about the completed general management plans for parks such as the Mormon Station and the Valley of Fire, and learn about plans that are currently under review. Visitors looking for helpful information about upcoming events can look over the "Other Park News!" area on the right hand side of the homepage. Finally, there's also detailed information about park fees, several photo galleries, and news releases.

264

Role of fibroblasts in the regulation of proinflammatory interleukin IL-1, IL-6 and IL-8 levels induced by keratinocyte-derived IL-1.  

PubMed

In the epidermis, the keratinocytes are the first cells to be encountered by external stimuli and they are able to promote the inflammatory response by increased production and release of various cytokines. In their turn, these cytokines may directly affect the production of proinflammatory cytokines in human dermal fibroblasts. In addition, in both epithelial and mesenchymal cells cytokine production may be modulated by their mutual interaction, and thereby regulate the inflammatory response. The present study aimed to examine the role of fibroblasts in the regulation of proinflammatory IL-1, IL-6 and IL-8 levels induced by keratinocyte-derived IL-1. The data show that in fibroblasts exposed to conditioned media derived from cultures of normal human keratinocytes or squamous carcinoma cells (SCC-4), both the IL-8 and IL-6 mRNA expression as well as protein production were elevated. In addition, it was shown that these effects were induced by IL-1 alpha. The IL-1 alpha-induced increase in IL-8 and IL-6 production, both on the protein level as well as on the mRNA level, were concentration dependent and occurred almost simultaneously. While the induction of IL-6 and IL-8 occurred simultaneously, the IL-6 mRNA remained elevated for longer. In contrast to increased IL-6 and IL-8 production the IL-1 alpha levels markedly decreased upon culturing of fibroblasts in keratinocyte-derived conditioned medium. From internalization experiments it could be concluded that binding of IL-1 to IL-1 receptors, and its subsequent internalization and intracellular degradation is the most likely mechanism involved in the reduction of IL-1 levels by fibroblasts. Comparing the rate of IL-1 reduction in the presence of various cell types indicated that the rate of IL-1 reduction is directly related to the number of IL-1 receptors found on these cell types. In conclusion, these results indicate that the release of IL-1 alpha by activated keratinocytes may act as an inducer of IL-8 and IL-6 production in neighbouring fibroblasts. This may be an important pathway for the amplification of the inflammatory response. The amounts of both cytokines produced by fibroblasts were at least two to three orders of magnitude higher than those produced by keratinocytes, suggesting an important role of fibroblasts in the general inflammatory response. Furthermore, fibroblasts might be involved in turning off this inflammatory response by reducing IL-1 levels, most likely via IL-1 receptor-mediated uptake. PMID:8818187

Boxman, I L; Ruwhof, C; Boerman, O C; Löwik, C W; Ponec, M

1996-06-01

265

Wheeling and Dealing in the National Parks  

ERIC Educational Resources Information Center

Motor vehicles and commercialism have generated serious problems within the national park system. A Conservation Foundation suggests new directions in management for the National Park Service. (Editors)

Howe, Sydney

1973-01-01

266

Science in the National Parks  

NSDL National Science Digital Library

This new addition to The National Park Service's website provides an overview of a huge array of research projects being conducted in US National Parks. Scientific studies are listed and summarized here (by Park), and include research on Nitrogen fixation, Neotropical migratory birds, meadow restoration, glacier research, and monitoring of wolf populations, to name a few. In addition, a list of Partners in Scientific Research is available at the site, as are current and archived copies of the agency's quarterly research and resource management bulletin Park Science. The exceptional value of the site is that it provides what most researchers don't have: detailed insights into different components (and scales) of the same ecosystem. Application procedures are included for those interested in conducting research at National Parks.

United States. National Park Service.

267

National Park Service Photo Collection  

NSDL National Science Digital Library

Over the past century, a host of photographers have documented the grounds and buildings of the National Parks for the National Park Service, and in doing so have created a collection that contains over two million images. Some of these eminent photographers include such personages as Jack Boucher, Arno B. Cammerer, and Abbie Rowe. The National Park Service has recently placed 2000 of these images online, and added a fine search feature so that users can look for images by year, photographer, theme, parksite, or keyword. Some of these images included early photographs of the Virgin Islands National Park, rangers on location in Yosemite National Park, and Canyon de Chelly National Monument. The site is rounded out with links to other digital image archives, such as those housed on the American Memory website at the Library of Congress.

268

Serum IL-17 and IL-6 increased accompany with TGF-? and IL-13 respectively in ulcerative colitis patients  

PubMed Central

Purposes: To explorer the serum level of pro- and anti-inflammatory cytokines in the patients of ulcerative colitis and irritable bowel disease. And analyze the correlation between the cytokine’s levels and disease’s activity of ulcerative colitis patients. Methods: Serum cytokines of ulcerative colitis and irritable bowel syndrome with diarrhea patients including IL-6, IL-10, IL-13, IL-17, TNF-? and TGF-? were analyzed by enzyme linked immunosorbent assay, and ulcerative colitis activity were assessed by Mayo scoring system. The correlation of the serum level of cytokines and ulcerative colitis activity were analyzed by the SPSS 19.0 software. Results: Compared with healthy people, the serum level of IL-6, IL-10, IL-13, IL-17, TNF-? and TGF-? were elevated in ulcerative colitis patients. There is no direct correlation between each cytokines analyzed and the Mayo score. And the level of IL-6 is relevant to IL-13 (r=0.364, P=0.029), and the level of IL-17 is relevant to TGF-? (r=0.336, P=0.045). Conclusion: When the pro-inflammatory cytokines increase in the serum of ulcerative colitis, the anti-inflammatory cytokines were increased concomitantly, Some cytokines are positive correlated, such as IL-6 and IL-13, IL-17 and TGF-?, the mechanism of which is complex and needs further investigation. PMID:25664061

Feng, Jin-Shan; Yang, Zheng; Zhu, Yu-Zhen; Liu, Zhou; Guo, Can-Can; Zheng, Xue-Bao

2014-01-01

269

A Lagrange-multiplier-based XFEM to solve pressure Poisson equations in problems with quasi-static interfaces  

NASA Astrophysics Data System (ADS)

The XFEM (extended finite element method) has a lot of advantages over other numerical methods to resolve discontinuities across quasi-static interfaces due to the jump in fluidic parameters or surface tension. However, singularities corresponding to enriched degrees of freedom (DOFs) embedded in XFEM arise in the discrete pressure Poisson equations. In this paper, constraints on these DOFs are derived from the interfacial equilibrium condition and introduced in terms of stabilized Lagrange multipliers designed for non-boundary-fitted meshes to address this issue. Numerical results show that the weak and strong discontinuities in pressure with straight and circular interfaces are accurately reproduced by the constraints. Comparisons with the SUPG/PSPG (streamline upwind/pressure stabilizing Petrov-Galerkin) method without Lagrange multipliers validate the applicability and flexibility of the proposed constrained algorithm to model problems with quasi-static interfaces.

Liao, JianHui; Zhuang, Zhuo

2012-04-01

270

Cratylia mollis 1, 4 lectin: a new biotechnological tool in IL-6, IL-17A, IL-22, and IL-23 induction and generation of immunological memory.  

PubMed

Cratylia mollis lectin has already established cytokine induction in Th1 and Th2 pathways. Thereby, this study aimed to evaluate Cramoll 1, 4 in IL-6, IL-17A, IL-22, and IL-23 induction as well as analyze immunologic memory mechanism by reinducing lymphocyte stimulation. Initially we performed a screening in cultured splenocytes where Cramoll 1, 4 stimulated IL-6 production 5x more than ConA (P < 0.05). The same behavior was observed with IL-22 where the increase was greater than 4x. Nevertheless, IL-17A induction was similar for both lectins. In PBMCs, the same splenocytes course was observed for IL-6 and IL-17A. Concerning the stimulation of IL-22 and IL-23 Cramoll 1, 4 was more efficient than ConA in cytokines stimulation mainly in IL-23 (P < 0.01). Analyzing reinduced lymphocyte stimulation, IL-17A production was higher (P < 0.001) when the first stimulus was realized with Cramoll 1, 4 at 1 ? g/mL and the second at 5 ? g/mL. IL-22 shows significant differences (P < 0.01) at the same condition. Nevertheless, IL-23 revels the best response when the first stimuli was realized with Cramoll1, 4 at 100 ng/mL and the second with 5 ? g/mL. We conclude that the Cramoll 1, 4 is able to induce IL-6, IL-17A, IL-22, and IL-23 cytokines in vitro better than Concavalin A, besides immunologic memory generation, being a potential biotechnological tool in Th17 pathway studies. PMID:23586026

de Oliveira, Priscilla Stela Santana; Ręgo, Moacyr Jesus Barreto de Melo; da Silva, Rafael Ramos; Cavalcanti, Mariana Brayner; Galdino, Suely Lins; Correia, Maria Tereza dos Santos; Coelho, Luana Cassandra Breitenbach Barroso; Pitta, Maira Galdino da Rocha

2013-01-01

271

Quantitative analysis of IL-2 and IL-15 signal transduction in T lymphocytes  

E-print Network

IL-2 and IL-15 are common y-chain family cytokines critically involved in regulation of T cell differentiation and homeostasis. Both cytokines signal through a heterotrimeric surface receptor complex (IL-2/15R) composed ...

Arneja, Abhinav

2013-01-01

272

Implementation of the Euler-Lagrange and poisson equations to extract one connected region  

NASA Astrophysics Data System (ADS)

This paper presents a numerical method that evolves an active contour toward the boundary of one connected image region. The numerical method implements a model which uses the solution of the Euler-Lagrange Differential Equation in order to minimize a "snake" functional. This functional is constructed as an integral of the so called internal and external energies. The internal energy is related to the moving contour. The external energy represents the image. The minimum of the functional falls on the boundaries of objects placed in the image. A half step numerical scheme implements the concepts. The contributions of the new model come from the use of the solution of the Poisson equation and development of a new penalty function to halt the contour on the object's boundary. In order to make the contour move across homogeneous regions and enlarge the capture range, we solve the Poisson equation with Dirichlet boundary conditions and generate a gradient vector field of the image. The numerical method is implemented with MatLab and uses a stop condition based on the gradient. The advantages of the model are that it has a large capture range, is accurate in detecting the boundaries of image objects, and is capable of surpassing noise. A disadvantage is that the user has to select the right values of three parameters. Several experiments with synthetic, weapon, and medical images have been conducted to validate the model. Our work continues with the goal of cutting the curve in the event multiple objects have been enveloped.

Bowden, A.; Todorov, M. D.; Sirakov, N. M.

2014-11-01

273

The Feasibility of Shading the Greenhouse with Dust Clouds at the Stable Lunar Lagrange Points  

E-print Network

There are many indications that anthropogenic global warming poses a serious threat to our civilization and its ecological support systems. Ideally this problem will be overcome by reducing greenhouse gas emissions. Various space-based methods, including large-scale solar shades, diffusers or atmospheric pollutants, have been considered to reduce the solar constant (input flux) and the warming in case emissions reductions are not achieved in a timely way. Here it is pointed out that proposed technologies for near-Earth orbiting comet deflection, suggest a different kind of space-based solar shade. This shade would be made up of micron-sized dust particles derived from comet fragments or lunar mining, and positioned in orbits near the triangular Lagrange points of the Earth-Moon system. Solar radiation pressure can render such orbits unstable, but a class of nearly resonant, and long-lived orbits is shown to exist, though the phase space volume of such orbits depends on dust grain size. Advantages and disadvantages of this scheme relative to others are considered.

Curtis Struck

2007-01-25

274

On the error propagation of semi-Lagrange and Fourier methods for advection problems?  

PubMed Central

In this paper we study the error propagation of numerical schemes for the advection equation in the case where high precision is desired. The numerical methods considered are based on the fast Fourier transform, polynomial interpolation (semi-Lagrangian methods using a Lagrange or spline interpolation), and a discontinuous Galerkin semi-Lagrangian approach (which is conservative and has to store more than a single value per cell). We demonstrate, by carrying out numerical experiments, that the worst case error estimates given in the literature provide a good explanation for the error propagation of the interpolation-based semi-Lagrangian methods. For the discontinuous Galerkin semi-Lagrangian method, however, we find that the characteristic property of semi-Lagrangian error estimates (namely the fact that the error increases proportionally to the number of time steps) is not observed. We provide an explanation for this behavior and conduct numerical simulations that corroborate the different qualitative features of the error in the two respective types of semi-Lagrangian methods. The method based on the fast Fourier transform is exact but, due to round-off errors, susceptible to a linear increase of the error in the number of time steps. We show how to modify the Cooley–Tukey algorithm in order to obtain an error growth that is proportional to the square root of the number of time steps. Finally, we show, for a simple model, that our conclusions hold true if the advection solver is used as part of a splitting scheme.

Einkemmer, Lukas; Ostermann, Alexander

2015-01-01

275

A Free-Lagrange method for unsteady compressible flow: simulation of a confined cylindrical blast wave  

NASA Astrophysics Data System (ADS)

A Free-Lagrange numerical procedure for the simulation of two-dimensional inviscid compressible flow is described in detail. The unsteady Euler equations are solved on an unstructured Lagrangian grid based on a density-weighted Voronoi mesh. The flow solver is of the Godunov type, utilising either the HLLE (2 wave) approximate Riemann solver or the more recent HLLC (3 wave) variant, each adapted to the Lagrangian frame. Within each mesh cell, conserved properties are treated as piece-wise linear, and a slope limiter of the MUSCL type is used to give non-oscillatory behaviour with nominal second order accuracy in space. The solver is first order accurate in time. Modifications to the slope limiter to minimise grid and coordinate dependent effects are described. The performances of the HLLE and HLLC solvers are compared for two test problems; a one-dimensional shock tube and a two-dimensional blast wave confined within a rigid cylinder. The blast wave is initiated by impulsive heating of a gas column whose centreline is parallel to, and one half of the cylinder radius from, the axis of the cylinder. For the shock tube problem, both solvers predict shock and expansion waves in good agreement with theory. For the HLLE solver, contact resolution is poor, especially in the blast wave problem. The HLLC solver achieves near-exact contact capture in both problems.

Ball, G. J.

1996-02-01

276

Parks, wilderness and recreation  

SciTech Connect

Parks and wilderness are a unique experiment in public ownership and management with no significant counterparts in our national experience. Despite occasional controversy, the propriety of large-scale federal land ownership and management was a settled issue long before the era of big national government or federal regulation began. This gave rise to a paradox with greater continuity in federal policy and public perception of land policy on one hand and the dislocating of old, established federal land management bureaucracies on the other. The author shows in the history of the wilderness movement that the American system is capable of producing real change; that reform is possible even if the methods are unexpected. Sharing the power among the administration, courts, and legislature opens the process to a range of interest groups with different opportunities for access. As values change, the system makes transitions manageable.

Sax, J.L.

1984-01-01

277

Lincoln Park Neighborhood Collection  

NSDL National Science Digital Library

Today, the Lincoln Park neighborhood on Chicago's North Side is a relatively affluent area, complete with Victorian mansions and rather tony elevator apartment buildings. By the late 1940s, the area was experiencing the same type of urban disinvestment as other inner-city neighborhoods throughout the United States. In the early 1960s, the city of Chicago, working with funds from the federal government, began an ambitious urban renewal program designed to reduce the density of the built environment in the community and to remove "blighted" properties. This excellent collection from the DePaul University Libraries Digital Collections contains over 400 documents related to this ambitious project, including maps, zoning documents, policy statements, neighborhood organization planning documents, and photographs. First-time visitors may wish to start with the first document here, "A Brief Explanation of the Urban Community Conservation Act." Moving on, visitors can view the rest of the documents by title, thumbnail, subject, and brief description.

278

Elevated Plasma IL-37, IL-18, and IL-18BP Concentrations in Patients with Acute Coronary Syndrome  

PubMed Central

Objective. More recently, evidence showed that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in the foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting that IL-37 is involved in atherosclerosis-related diseases. However, the plasma levels of IL-37 in patients with acute coronary syndrome (ACS, including unstable angina pectoris and acute myocardial infarction) have yet to be investigated. Methods. Plasma IL-37, IL-18, and IL-18BP levels were measured in 50 patients with stable angina pectoris (SAP), 75 patients with unstable angina pectoris (UAP), 67 patients with acute myocardial infarction (AMI), and 65 control patients. Results. The plasma IL-37, IL-18, and IL-18BP levels were significantly increased in ACS patients compared to SAP and control patients. A correlation analysis showed that the plasma biomarker levels were positively correlated with each other and with the levels of C-reactive protein (CRP), N-terminal probrain natriuretic peptide (NT-proBNP), and left ventricular end-diastolic dimension (LVEDD) but negatively correlated with left ventricular ejection fraction (LVEF). Furthermore, the plasma IL-37, IL-18, and IL-18BP had no correlation with the severity of the coronary artery stenosis. Conclusions. The results indicate that the plasma IL-37 levels are associated with the onset of ACS. PMID:24733959

Ji, Qingwei; Zeng, Qiutang; Huang, Ying; Shi, Ying; Lin, Yingzhong; Lu, Zhengde; Meng, Kai; Wu, Bangwei; Yu, Kunwu; Chai, Meng; Liu, Yuyang

2014-01-01

279

Chicago Public Library: Millennium Park  

NSDL National Science Digital Library

The transformation of the area east of Michigan Avenue from an industrial wasteland into the vibrant and heavily-used Millennium Park is truly a remarkable tale in Chicago's recent history. The apocryphal tale says that Mayor Richard M. Daley looked out from his dentist's office and envisioned a public park that would be comparable to other grand spaces in the city. The construction of Millennium Park took quite some time, but when the park was finished in 2004, most people were quite happy with it. This digital collection from the Chicago Public Library brings together over 5,100 images of the park at various phases of its construction. Visitors can view a highlights file of 154 images, and they can wander through topical areas like Cloud Gate, Crown Fountain, and Lurie Garden. Visitors interested in broad vistas of the entire setting should click on Full Park. Finally, visitors can use the tabs on the left-hand side of the page to look at architectural renderings and models of the park's various sections.

2012-03-16

280

Aftermath of Griffith Park Fire  

NASA Technical Reports Server (NTRS)

In mid-May 2007, wind-driven flames raced through Griffith Park in Los Angeles, forcing hasty evacuations and threatening numerous famous landmarks and tourist spots, such as the Los Angeles Zoo and the Hollywood Sign. Ultimately, no one was injured in the fire, which may have been started by a cigarette. About 800 acres burned in the urban park, which is itself a Hollywood landmark, having been the location for several movies, including Rebel Without A Cause. This image of the park was captured by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite on June 6, 2007, about a month after the fire. ASTER detects both visible and infrared wavelengths of light, and both kinds have been used to make this image. Vegetation appears in various shades of red, while the burned areas appear charcoal. Roads and dense urban areas appear purplish-gray or white. Water is dark blue. Large burned areas are evident in the northwest and southeast parts of the park, with scattered smaller patches along the southern margin. Some botanical gardens and parts of a bird sanctuary, as well as some park structures like restrooms, were destroyed. The park's unburned, natural vegetation appears brick red, while the irrigated golf courses adjacent to the park are bright red. NASA image created by Jesse Allen, using data provided courtesy of the NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.

2007-01-01

281

Dreaming of a Better ILS  

ERIC Educational Resources Information Center

What would technological librarians like to see in the next generation of Integrated Library Systems (ILS)? This question was asked of several well- known library technology experts, and their responses are presented in this article. Survey respondents expressed a clear desire for the following features and functionality: (1) Direct, read-only…

Bahr, Ellen

2007-01-01

282

A Novel Immunoregulatory Function for IL-23: Inhibition of IL-12 Dependent IFN-? Production  

PubMed Central

Summary Most studies investigating the function of IL-23 have concluded that it promotes IL-17 secreting T cells. While some reports have also characterized IL-23 as having redundant pro-inflammatory effects with IL-12, we have instead found that IL-23 antagonizes IL-12 induced secretion of IFN-?. When splenocytes or purified populations of T cells are cultured with IL-23, IFN-? secretion in response to IL-12 is dramatically reduced. The impact of IL-23 is most prominent in CD8 T cells, but is also observed in NK and CD4 T cells. Mechanistically, the IL-23 receptor is not required for this phenomenon, and IL-23 inhibits signaling through the IL-12 receptor by reducing IL-12 induced signal transducer and activator of transcription 4 (STAT4) phosphorylation. IL-23 is also able to reduce IFN-? secretion by antagonizing endogenously produced IL-12 from Listeria monocytogenes (LM) infected macrophages. In vivo, LM infection induces higher serum IFN-? levels and a greater percentage of IFN-?+CD8+ T cells in IL-23p19 deficient mice as compared to wild-type mice. This increase in IFN-? production coincides with increased LM clearance at days 2–3 post-infection. Our data suggest that IL-23 may be a key factor in determining the responsiveness of lymphocytes to IL-12 and their subsequent secretion of IFN-?. PMID:20458705

Sieve, Amy N.; Meeks, Karen D.; Lee, Suheung; Berg, Rance E.

2011-01-01

283

Untangling the Complex Web of IL-4- and IL-13-Mediated Signaling Pathways  

NSDL National Science Digital Library

Unraveling the exact signaling events mediating the distinct functions of the T cell–derived cytokines interleukin-4 (IL-4) and IL-13 has been challenging because they are structurally similar and share a functional signaling receptor chain. A study now proposes a potential molecular mechanism to explain the functional differences between IL-4 and IL-13 that involves the ability of IL-4, but not IL-13, to effectively activate the insulin receptor substrate–2 (IRS-2) signaling cascade through binding to its receptor. A better understanding of the interactions of IL-4 and IL-13 with their cognate receptors may facilitate the development of therapies without unintended side effects.

Marsha Wills-Karp (Cincinnati Children's Hospital Medical Center; Division of Immunobiology REV)

2008-12-23

284

Park and chill : redesign parking garage in Hong Kong  

E-print Network

What are the aesthetics of urban infrastructure? Urban infrastructure has remained isolated to human activities. We all share memory and experience with urban infrastructure, e.g. we drive on the same roads and park our ...

Ting, Sze Ngai

2011-01-01

285

1.OA At the Park  

NSDL National Science Digital Library

This is a task from the Illustrative Mathematics website that is one part of a complete illustration of the standard to which it is aligned. Each task has at least one solution and some commentary that addresses important asects of the task and its potential use. Here are the first few lines of the commentary for this task: There were 7 children at the park. Then 4 more showed up. How many children were at the park all together? There were 7 children at the park. Some more...

2012-05-01

286

Parking Slot Markings Recognition for Automatic Parking Assist System  

Microsoft Academic Search

This paper describes a monocular vision based parking-slot-markings recognition algorithm, which is used to automate the target position selection of automatic parking assist system. Peak-pair detection and clustering in Hough space recognize marking lines. Specially, one-dimensional filter in Hough space is designed to utilize a priori knowledge about the characteristics of marking lines in bird's eye view edge image. Modified

Ho Gi Jung; Dong Suk Kim; Pal Joo Yoon; Jaihie Kim

2006-01-01

287

Yellowstone National Park: Historic 3-D Photographs Featuring Park Geology  

NSDL National Science Digital Library

This source provides a series of 34 historic photographs of well-known geologic landmarks in Yellowstone National Park. The photographs can be viewed individually or as part of a tour that begins at Old Faithful and proceeds in a clockwise route around the park. The images were created by digital manipulation of antique stereographs and they may be viewed as black and white photos or in 3-D using special stereographic glasses.

Stoffer Phil

288

Autonomous parking carrier for intelligent vehicle  

Microsoft Academic Search

In this paper, we consider a parking method for autonomous vehicle in an underground car park. The implemented method is decomposed into three tasks. Starting from configuration given by the vehicle owner, the first one is the motion control of the vehicle from his residence to the car park. After joining the underground car park thanks to the implementation of

E. Seignez; A. Lambert; T. Maurin

2005-01-01

289

Nontraditional uses of the National parks  

Microsoft Academic Search

National parks are increasingly attracting visitors with diverse and sometimes unusual expectations, often referred to as nontraditional activities. The purposes of this study were: (1) identify which recreation activities were seen as inappropriate to national parks, (2) identify reasons for inappropriateness, (3) relate these reasons to perceptions of the meaning of national parks.Two hundred eleven visitors to seven Park Service

Robert G. White; Richard Schreyer

1981-01-01

290

Mojave National Preserve Joshua Tree National Park  

E-print Network

Death Valley Mojave National Preserve Joshua Tree National Park National Park National Training Los Angeles San Diego Needles Blythe Salton Sea Anza- Borrego State Park San Bernardino National Contingent Corridor Deleted Corridor Land Status BLM National Park Service Forest Service Military USFWS

Laughlin, Robert B.

291

Man Sik Park Symmetry and Separability In  

E-print Network

Man Sik Park Symmetry and Separability In Spatial-Temporal Processes Man Sik Park, Montserrat Fuentes Symmetry and Separability In Spatial-Temporal Processes 1 #12;Man Sik Park Motivation · In general-pollution data. Symmetry and Separability In Spatial-Temporal Processes 2 #12;Man Sik Park Research Objectives 1

292

The international politics of national parks  

Microsoft Academic Search

National parks are the keystone institutions of environmental conservation. Because national parks make certain lands part of the state itself, international agencies and nongovernmental organizations that promote national parks propose, in effect, to alter the state, as well as the local economy and state relations with social groups. Has international political pressure caused states to create national parks? I consider

Karen M. O'Neill

1996-01-01

293

February 2014 STAFF APPLICATION FOR CAR PARKING  

E-print Network

February 2014 STAFF APPLICATION FOR CAR PARKING Car Parks Office Security & Portering Services@cardiff.ac.uk The 2014 fee for staff car parking is 0.75% of gross annual salary or ÂŁ192.00, whichever is lower. Changes) Model (Focus) Colour 1. 2. Car Parks In Order Of Preference 1st : 2nd : 3rd : The following

Davies, Christopher

294

February 2014 STUDENT APPLICATION FOR CAR PARKING  

E-print Network

February 2014 STUDENT APPLICATION FOR CAR PARKING Car Parks Office Security & Portering Services@cardiff.ac.uk Limited spaces are available in the Cranbrook car parks for students living at Senghennydd Court only. The charge for car parking for session 2013/14 is ÂŁ132.00, exclusive of VAT, payable in advance. CHEQUES

Davies, Christopher

295

Standard structures For roadside, car parks,  

E-print Network

Standard structures For roadside, car parks, visitor information, wayfinding & waymarking Forestry visitor centres. Suitable locations At road entrance to car park/driveway Symbols Up to 5 symbols is for Entrances to medium-sized car parks Suitable locations At road entrance to car park Symbols Up to 3 symbols

296

Industrial park management in the Chinese environment  

Microsoft Academic Search

In China many investments especially from foreign companies are located in industry parks. However, the general situation and management perspectives of developing Chinese industrial parks are not very clear to the westerners. With the rapid development, industrial parks will play a key role in China's economy, therefore, those issues relating with China's industrial parks need to be further discussed. This

Yong Geng; Zhao Hengxin

2009-01-01

297

SPARK: A New VANET-Based Smart Parking Scheme for Large Parking Lots  

Microsoft Academic Search

Searching for a vacant parking space in a congested area or a large parking lot and preventing auto theft are major concerns to our daily lives. In this paper, we propose a new smart parking scheme for large parking lots through vehicular communication. The proposed scheme can provide the drivers with real-time parking navigation service, intelligent anti- theft protection, and

Rongxing Lu; Xiaodong Lin; Haojin Zhu; Xuemin Shen

2009-01-01

298

The socio?economic impact of an urban park: the case of Wilderness National Park  

Microsoft Academic Search

Most of South Africa’s national parks are based in rural areas, although a few parks – such as Wilderness National Park (WNP) – are situated in an urban area. This park differs from other national parks in several ways: it is not fenced in, it has very few animal species and it is a marine (fresh and salt water) reserve.

Melville Saayman; Petrus Van der Merwe; Andrea Saayman; Maria Elizabeth Mouton

2009-01-01

299

GEOGRAPHIC PERSPECTIVES OF A NATIONAL PARK AND A PROVINCIAL PARK ON THE GASPE PENINSULA  

Microsoft Academic Search

Forillon National Park and Bonaventure Island and Perce Rock National Park, on the Gaspe Peninsula, Quebec, both established in the I970s, mesh unique geologic landscapes, biogeographic ecosystems, and human geographic environments. While Forillon is a Canadian national park, Bonaventure Island and Perce Rock, though actually a Quebec provincial park, is referred to as a Quebec national park because of its

Margaret F. Boorstein

300

University of Aberdeen Car Parking Policy 1.0 Why have a car parking policy?  

E-print Network

Document1 University of Aberdeen Car Parking Policy 1.0 Why have a car parking policy to such an extent that its current car park capacity is not sufficient to provide parking for all staff to improve and develop the University further, there is a need to control our car parking facilities

Pym, David J.

301

Criteria for Car Parking Allocation System Criteria for Car Parking Allocation System  

E-print Network

Criteria for Car Parking Allocation System Criteria for Car Parking Allocation System 2014-15 Criteria for Car Parking All #12;The issue and control of car parking permits is vested in Estates Services. The annual charges are incorporated in the application form. The car parking charges will be deducted from

Mottram, Nigel

302

Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity  

PubMed Central

Interleukin 4 (IL-4) and IL-13 are critical for responses against parasitic helminthes. Here we used genetically engineered reporter mice to assess the temporal and spatial production of these cytokine in vivo. In lymph nodes, IL-4 was confined to T follicular helper (TFH) cells, however these cells did not make IL-13. In contrast, tissue type 2 helper T TH2 cells produce both cytokines. Divergent IL-4 and IL-13 production also occurred among innate immune cells, where basophils produced IL-4, while innate helper type 2 (Ih2) cells produced IL-13. IL-13 production by TH2 and Ih2 cells was dependent on high GATA-3 levels, in contrast to low GATA-3 levels in TFH cells and basophils. Distinct localization and cellular expression of IL-4 and IL-13 explains their unique roles during allergic immunity. PMID:22138715

Liang, Hong-Erh; Reinhardt, R. Lee; Bando, Jennifer K.; Sullivan, Brandon M.; Ho, I-Cheng; Locksley, Richard M.

2011-01-01

303

Views of the National Parks  

NSDL National Science Digital Library

There is no true substitute for visiting one of America's great national parks, but this website, designed "to present the natural, cultural, and historical resources of our national parks," is a nice surrogate for an in-person jaunt. On the homepage, visitors can select a park or theme from several dozen headings, including National Mall, Whiskeytown, Glaciers, and Devils Tower. Within each area, visitors can examine a series of high-quality images, along with four or five sections that address different aspects of each topic or specific park. Perhaps the most useful elements of the site are the very fine resources for teachers. Clicking on the Teachers' Lounge area will bring up a number of high-quality educational articles, lesson plans, and educational standards guidelines. All told, there are 14 different lesson plans here, which are complemented by links to external resources and additional readings. [KMG

304

Renovation proposal for Fenway Park  

E-print Network

As the oldest stadium in baseball history, the existing structure of Fenway Park presents problems such as limiting seating capacity and obstructed views, caused by the columns supporting the second level. Opened in 1912, ...

Aldana Urrutia, Luis Pedro

2009-01-01

305

MARY PARK HALL THE VILLAGE  

E-print Network

, forage, and habitat for bees, butterflies,and birds. Mary Park Hall Community Garden: Students can grow://sfbike.org/download/map.pdf Habitat Gardens: The Campus maintains gardens with over 150 species of native plants that provide food

306

Travel Operations College Park 300  

E-print Network

occurs first). 5. Estimated Expenses Fill in the estimated expenses for #5A through #5G. 5. A. Conference at an event (refer to 5.G.). #12;Travel Operations College Park 300 Em ail: travel@fu llerton .edu EMPLOYEE

de Lijser, Peter

307

Travel Operations College Park 300  

E-print Network

occurs first). 5. Estimated Expenses Fill in the estimated expenses for #5A through #5G. 5. A. Conference at an event (refer to 5.G.). #12;Travel Operations College Park 300 Email: travel@fullerton.edu EMPLOYEE

de Lijser, Peter

308

Morris Park Ave Rhinelander Ave  

E-print Network

Albert Einstein College of Medicine ALBERT EINSTEIN COLLEGE OF MEDICINE JACK AND PEARL RESNICK CAMPUS Building 19. Einstein Boiler Plant JACOBI MEDICAL CENTER 20. Nurses' Residence MEDICAL PARK EINSTEIN PROGRAM LOCATIONS Glass Building Ob/Gyn Private Practice

Kenny, Paraic

309

The Science Behind Jurassic Park  

NSDL National Science Digital Library

"The Science Behind Jurassic Park" is an html document describing how world renowned paleontologist Jack Horner is using computers and CAT scan machines to peer inside 30 million year old dinosaur fossils.

310

Tour of Park Geology: Colorado Plateau  

NSDL National Science Digital Library

This site provides links to geology fieldnotes about National Parks, Monuments, and Recreation Areas that are part of the Colorado Plateau. Each park site provides links to visitor information, photographs, park maps, multimedia resources, and teacher features (tools for teaching geology with National Park examples). Some of the areas linked to this site include: Dinosaur National Monument, Mesa Verde National Park, and Glen Canyon National Recreation Area.

311

Arches National Park - Nature and Science  

NSDL National Science Digital Library

This National Park Service (NPS) website highlights the natural resources of Arches National Park, in addition to the sandstone arches for which the park is famous. Details about the park include the animals that inhabit the area (amphibians, birds, mammals and reptiles), natural features (deserts, geologic formations, pools, potholes and soils), environmental factors facing the park (invasive species, perigrine falcons, bighorn sheep), and plants (cacti, grasses, lichens, mosses, liverworts, trees, shrubs and wildflowers).

312

INTELLIGENT CAR PARKING LOCATOR SERVICE  

Microsoft Academic Search

Abstract: This paper presents an InfoStation-based multi-agent system facilitating a Car Parking Locator service provision within a University Campus. The system network architecture is outlined, illustrating its functioning during the service provision. A detailed description of the Car Parking Locator service is given and the system entities’ interaction is described. System implementation approaches are also considered. Keywords: InfoStations, intelligent agents,multi-agent

Ivan Ganchev; Máirtín O'droma; Damien Meere

313

University of Campus Parking Garage  

E-print Network

University of Zurich Oerlikon Campus Parking Garage Eisfeld SChliErEn StatiOn OErlikOn StatiOn main Garage am Central University of Zurich irchel Campus University of Zurich Schlieren Campus limmat Parking-bill-PlatZ bahnhOf OErlikOn OSt SChliErEn StatiOn OErlikOn StatiOn SChliErEn ZEntrUm/ bahnhOf SChliErEn bahnh

Zürich, Universität

314

Circulating proinflammatory cytokines (IL-1 beta, TNF-alpha, and IL-6) and IL-1 receptor antagonist (IL-1Ra) in fulminant hepatic failure and acute hepatitis.  

PubMed Central

Fulminant hepatic failure (FHF) is characterized by massive necroinflammation of the liver tissue and is associated with high mortality. Serum concentrations of IL-1 beta, tumour necrosis factor-alpha (TNF-alpha), IL-6 and IL-1 receptor antagonist (IL-1Ra) were measured in 30 patients with FHF and in 23 patients with acute hepatitis (AH) before start of treatment and in 23 healthy controls. Levels of all four molecules were increased significantly in FHF compared with AH, in which values were higher than in the healthy controls. High serum levels of IL-1 beta and a significantly reduced ratio of IL-1Ra to IL-1 beta (IL-1Ra/IL-1 beta) were observed in FHF patients who subsequently died compared with subjects who survived. TNF-alpha and IL-6 concentrations were correlated with levels of human hepatocyte growth factor (hHGF), an index of hepatocyte regeneration. Although serum cytokine levels varied considerably between patients within each group studied, it is suggested that the striking elevation in proinflammatory cytokine levels in FHF may reflect both the insufficiency of hepatitis virus elimination and a failure to control a vicious cytokine cascade leading to overwhelming hepatocyte destruction rather than regeneration. The high cytokine levels observed in these patients and the significantly elevated IL-1Ra/IL-1 beta ratio in FHF patients who survived compared with those who did not suggest the possible therapeutic use of cytokine antagonists for the control of this life-threatening disease. PMID:7923888

Sekiyama, K D; Yoshiba, M; Thomson, A W

1994-01-01

315

Il pumping lemma Proprieta' di chiusura  

E-print Network

Il pumping lemma Proprieta' di chiusura Proprieta' di decisione Proprieta' dei linguaggi regolari Proprieta' dei linguaggi regolari #12;Il pumping lemma Proprieta' di chiusura Proprieta' di decisione Proprieta' dei Linguaggi regolari Pumping Lemma. Ogni linguaggio regolare soddisfa il pumping lemma. Se

Rossi, Francesca

316

The Dichotomous Pattern of IL-12R and IL-23R Expression Elucidates the Role of IL-12 and IL-23 in Inflammation  

PubMed Central

IL-12 and IL-23 cytokines respectively drive Th1 and Th17 type responses. Yet, little is known regarding the biology of these receptors. As the IL-12 and IL-23 receptors share a common subunit, it has been assumed that these receptors are co-expressed. Surprisingly, we find that the expression of each of these receptors is restricted to specific cell types, in both mouse and human. Indeed, although IL-12R?2 is expressed by NK cells and a subset of ?? T cells, the expression of IL-23R is restricted to specific T cell subsets, a small number of B cells and innate lymphoid cells. By exploiting an IL-12- and IL-23-dependent mouse model of innate inflammation, we demonstrate an intricate interplay between IL-12R?2 NK cells and IL-23R innate lymphoid cells with respectively dominant roles in the regulation of systemic versus local inflammatory responses. Together, these findings support an unforeseen lineage-specific dichotomy in the in vivo role of both the IL-12 and IL-23 pathways in pathological inflammatory states, which may allow more accurate dissection of the roles of these receptors in chronic inflammatory diseases in humans. PMID:24586521

Dominguez-Punaro, Maria C.; Beauchamp, Claudine; Guyon, Marie-Josée; Charron, Guy; Morin, Nicolas; Sivanesan, Durga; Kuchroo, Vijay; Xavier, Ramnik; Michnick, Stephen W.; Chemtob, Sylvain; Rioux, John D.; Lesage, Sylvie

2014-01-01

317

Multinational underground nuclear parks  

SciTech Connect

Newcomer countries expected to develop new nuclear power programs by 2030 are being encouraged by the International Atomic Energy Agency to explore the use of shared facilities for spent fuel storage and geologic disposal. Multinational underground nuclear parks (M-UNPs) are an option for sharing such facilities. Newcomer countries with suitable bedrock conditions could volunteer to host M-UNPs. M-UNPs would include back-end fuel cycle facilities, in open or closed fuel cycle configurations, with sufficient capacity to enable M-UNP host countries to provide for-fee waste management services to partner countries, and to manage waste from the M-UNP power reactors. M-UNP potential advantages include: the option for decades of spent fuel storage; fuel-cycle policy flexibility; increased proliferation resistance; high margin of physical security against attack; and high margin of containment capability in the event of beyond-design-basis accidents, thereby reducing the risk of Fukushima-like radiological contamination of surface lands. A hypothetical M-UNP in crystalline rock with facilities for small modular reactors, spent fuel storage, reprocessing, and geologic disposal is described using a room-and-pillar reference-design cavern. Underground construction cost is judged tractable through use of modern excavation technology and careful site selection. (authors)

Myers, C.W. [Nuclear Engineering and Nonproliferation Division, Los Alamos National Laboratory, MS F650, Los Alamos, NM 87544 (United States); Giraud, K.M. [Wolf Creek Nuclear Operating Corporation, 1550 Oxen Lane NE, P.O. Box 411, Burlington, KS 66839-0411 (United States)

2013-07-01

318

Role of Interleukin-23 (IL-23) Receptor Signaling for IL-17 Responses in Human Lyme Disease ?  

PubMed Central

Interleukin-23 (IL-23) is known to play a crucial role in the development and maintenance of T helper 17 cells. It has been previously demonstrated that IL-17 is involved in experimental Lyme arthritis, caused by Borrelia burgdorferi bacteria. However, the precise role of the IL-23 receptor (IL-23R) for the B. burgdorferi-induced IL-17 responses or human Lyme disease has not yet been elucidated. IL-23R single nucleotide polymorphism (SNP) rs11209026 was genotyped using the TaqMan assay. Functional studies were performed using peripheral blood mononuclear cells, and cytokines were measured using enzyme-linked immunosorbent assay (ELISA). Dose-dependent production of IL-23 and IL-17 by B. burgdorferi could be observed. Interestingly, when IL-23 bioactivity was inhibited by a specific antibody against IL-23p19, IL-17 production was significantly downregulated. In contrast, production of gamma interferon (IFN-?) was not affected after the blockade of IL-23 activity. Moreover, individuals bearing a single nucleotide polymorphism in the IL-23R gene (Arg381Gln) produced significantly less IL-17 after B. burgdorferi stimulation compared with that of the individuals bearing the wild type. Despite lower IL-17 production, the IL-23R gene polymorphism did not influence the development of chronic Lyme disease in a cohort of patients with Lyme disease. This study demonstrates that IL-23R signaling is needed for B. burgdorferi-induced IL-17 production in vitro and that an IL-23R gene SNP leads to impaired IL-17 production. However, the IL-23R gene polymorphism is not crucial for the pathogenesis of chronic Lyme. PMID:21896776

Oosting, Marije; ter Hofstede, Hadewych; van de Veerdonk, Frank L.; Sturm, Patrick; Kullberg, Bart-Jan; van der Meer, Jos W. M.; Netea, Mihai G.; Joosten, Leo A. B.

2011-01-01

319

Role of interleukin-23 (IL-23) receptor signaling for IL-17 responses in human Lyme disease.  

PubMed

Interleukin-23 (IL-23) is known to play a crucial role in the development and maintenance of T helper 17 cells. It has been previously demonstrated that IL-17 is involved in experimental Lyme arthritis, caused by Borrelia burgdorferi bacteria. However, the precise role of the IL-23 receptor (IL-23R) for the B. burgdorferi-induced IL-17 responses or human Lyme disease has not yet been elucidated. IL-23R single nucleotide polymorphism (SNP) rs11209026 was genotyped using the TaqMan assay. Functional studies were performed using peripheral blood mononuclear cells, and cytokines were measured using enzyme-linked immunosorbent assay (ELISA). Dose-dependent production of IL-23 and IL-17 by B. burgdorferi could be observed. Interestingly, when IL-23 bioactivity was inhibited by a specific antibody against IL-23p19, IL-17 production was significantly downregulated. In contrast, production of gamma interferon (IFN-?) was not affected after the blockade of IL-23 activity. Moreover, individuals bearing a single nucleotide polymorphism in the IL-23R gene (Arg381Gln) produced significantly less IL-17 after B. burgdorferi stimulation compared with that of the individuals bearing the wild type. Despite lower IL-17 production, the IL-23R gene polymorphism did not influence the development of chronic Lyme disease in a cohort of patients with Lyme disease. This study demonstrates that IL-23R signaling is needed for B. burgdorferi-induced IL-17 production in vitro and that an IL-23R gene SNP leads to impaired IL-17 production. However, the IL-23R gene polymorphism is not crucial for the pathogenesis of chronic Lyme. PMID:21896776

Oosting, Marije; ter Hofstede, Hadewych; van de Veerdonk, Frank L; Sturm, Patrick; Kullberg, Bart-Jan; van der Meer, Jos W M; Netea, Mihai G; Joosten, Leo A B

2011-11-01

320

Structural and Biophysical Studies of the Human IL-7/IL-7R[alpha] Complex  

SciTech Connect

IL-7 and IL-7R{alpha} bind the {gamma}{sub c} receptor, forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells. We report that the IL-7R{alpha} ectodomain uses glycosylation to modulate its binding constants to IL-7, unlike the other receptors in the {gamma}{sub c} family. IL-7 binds glycosylated IL-7R{alpha} 300-fold more tightly than unglycosylated IL-7R{alpha}, and the enhanced affinity is attributed primarily to an accelerated on rate. Structural comparison of IL-7 in complex to both forms of IL-7R{alpha} reveals that glycosylation does not participate directly in the binding interface. The SCID mutations of IL-7R{alpha} locate outside the binding interface with IL-7, suggesting that the expressed mutations cause protein folding defects in IL-7R{alpha}. The IL-7/IL-7R{alpha} structures provide a window into the molecular recognition events of the IL-7 signaling cascade and provide sites to target for designing new therapeutics to treat IL-7-related diseases.

McElroy, Craig A.; Dohm, Julie A.; Walsh, Scott T.R.; (OSU); (UPENN)

2009-03-06

321

Two-touch type parking slot marking recognition for target parking position designation  

Microsoft Academic Search

This paper proposes a target parking position designation method based on parking slot marking recognition for automatic parking system. To reduce the search range and memory requirement, the driver designates two seed-points which are the end-point of two line-segments separating the target parking slot from adjacent parking slots. As the method does not require marking line separating parking area from

Ho Gi Jung; Dong Suk Kim; Pal Joo Yoon; Jaihie Kim

2008-01-01

322

IL-33 promotes eosinophilia in vivo and antagonizes IL-5-dependent eosinophil hematopoiesis ex vivo  

PubMed Central

IL-33 is an IL-1 family cytokine that elicits IL-5-dependent eosinophilia in vivo. We show here that IL-33 promotes minimal eosinophil hematopoiesis via direct interactions with mouse bone marrow progenitors ex vivo and that it antagonizes eosinophil hematopoiesis promoted by IL-5 on SCF and Flt3L primed bone marrow progenitor cells in culture. SCF and Flt3L primed progenitors respond to IL-33 by acquiring an adherent, macrophage-like phenotype, and by releasing macrophage-associated cytokines into the culture medium. IL-33-mediated antagonism of IL-5 was reproduced in part by the addition of GM-CSF and was inhibited by the actions of neutralizing anti-GM-CSF antibody. These findings suggest that the direct actions of IL-33 on bone marrow progenitors primed with SCF and Flt3L are antagonistic to the actions of IL-5 and are mediated in part by GM-CSF. PMID:23246474

Dyer, Kimberly D; Percopo, Caroline M; Rosenberg, Helene F

2012-01-01

323

Roles of elevated intravitreal IL-1? and IL-10 levels in proliferative diabetic retinopathy  

PubMed Central

Purpose: To determine the roles of interleukin (IL)-1? and IL-10 in the vitreous of proliferative diabetic retinopathy (PDR). Materials and Methods: Vitreous samples were obtained from 26 eyes of 26 patients with PDR and from eight eyes of eight cases without PDR. The IL-1? and IL-10 concentration in the vitreous was measured by using an enzyme-linked immunosorbent assay (ELISA). Results: Levels of IL-1? and IL-10 in vitreous were higher in PDR patients compared with control group. And there was significantly negative correlation between IL-1? and IL-10 in control group (r = ?0.795; P = 0.032), whereas there was no significant correlation in PDR group (r = 0.176; P = 0.391). Conclusion: Levels of IL-1? and IL-10 were upregulated in vitreous of PDR patients, and these two cytokines play roles in regulating the development and progression of PDR. PMID:25005199

Mao, Chunjie; Yan, Hua

2014-01-01

324

IL-13 Signaling in Liver Fibrogenesis  

PubMed Central

Liver fibrosis is the final common pathway of chronic liver diseases irrespective of etiology. However, etiology deeply impacts progression and characteristics of liver fibrogenesis. IL-13 is the dominant pro-fibrotic cytokine in Schistosomiasis associated liver fibrogenesis. In vitro, IL-13 directly induces expression of fibrosis-associated genes, e.g., collagens or connective tissue growth factor, in hepatic stellate cells. Recently, potential effects of IL-13 in non-Schistosomiasis associated liver fibrosis have been uncovered. This review summarizes the potential roles of IL-13 in chronic liver disease of different etiologies, and the downstream events mediating IL-13 signaling in liver fibrogenesis. PMID:22593760

Liu, Yan; Munker, Stefan; Müllenbach, Roman; Weng, Hong-Lei

2012-01-01

325

Biological significance of soluble IL-2 receptor  

PubMed Central

A NUMBER of receptors for growth factors and differentiation antigens have been found to be secreted or released by cells. Following mononuclear cell (MNC) activation and interleukin-2 receptor (IL-2R) expression, a soluble form of the Alpha;-chain of IL-2R (sIL-2R) is released. The sIL-2R has been shown to be present in the culture supernatants of activated MNCs as well as in normal sera and, in higher amounts, in sera from subjects affected by several diseases including neoplastic, infectious and autoimmune ones, and in sera from transplanted patients suffering allograft rejection. The blood sIL-2R levels depend on the number of producing cells and the number of molecules per cell, so that sIL-2R blood values may represent an index of the number and the functional state of producing cells, both normal and neoplastic. Thus, monitoring of the immune system, mostly T-cells and haematological malignancies might be targets for the measurement of sIL-2R. Since many conditions may influence sIL-2R production, little diagnostic use may result from these measurements. However, since blood sIL-2R levels may correlate with disease progression and/or response to therapy, their measurement may be a useful index of activity and extent of disease. The precise biological role of the soluble form of the IL-2R is still a matter of debate. However, we know that increased sIL-2R levels may be observed in association with several immunological abnormalities and that sIL-2R is able to bind IL-2. It is conceivable then that in these conditions the excess sIL-2R released in vivo by activated lymphoid cells or by neoplastic cells may somehow regulate IL-2-dependent processes. On the other hand, it cannot exclude that sIL-2R is a by-product without biological significance. Finally, it is puzzling that in many conditions in which an increase of blood sIL-2R values has been observed, MNCs display a decreased in vitro capacity to produce sIL-2R. These seemingly contrasting findings are discussed in the light of the data showing that sIL-2R production correlates with IL-2 production. PMID:18475497

Candore, Giuseppina; Cigna, Diego; Colucci, Antonio Tobia; Modica, Maria Assunta

1993-01-01

326

Mesa Verde National Park: Educational Resources  

NSDL National Science Digital Library

This National Park Service site contains general information on planning a visit to the park; information on plants, animals, geology, cliff dwellings, surface archaeological sites, and history of the park; and a classroom activities section. School group activities at the park include identifying geologic formations, seeing museum videos and dioramas, going on trails and tours, and attending evening campground programs. Classroom activities involve the use of a park map, the development of ancestral Puebloan society from about AD 1 to AD 1300, and the history of the National Park Service.

327

Geology Fieldnotes: Badlands National Park, South Dakota  

NSDL National Science Digital Library

Badlands National Park, located in southwestern South Dakota, consists of 244,000 acres of sharply eroded buttes, pinnacles and spires blended with the largest, protected mixed grass prairie in the United States. Features include information on park geology, maps, photographs, visitor information, links to related publications, and lesson plans for teaching geology with National Park examples. The park geology section discusses the Park's geologic history during the Eocene and Oligocene epochs and the rich fossil deposits found there. Maps of the park and the surrounding area are included.

328

Tour of Park Geology: Mountain Building  

NSDL National Science Digital Library

This site provides links to tours of National Parks, National Monuments, and Recreation Areas associated with major mountain building periods. The parks are divided into groups by mountain building events: Appalachian, Laramide, and others. Where appropriate, links are provided to park geology, maps, photographs, geologic research, related links, visitor information, multi-media, and teacher features (resources for teaching geology with National Park examples). The list includes places such as: Delaware Water Gap National Recreation Area, Shenandoah National Park, Devils Tower National Monument, Mt. Rushmore National Monument, Yosemite National Park, and more.

329

Tour of Park Geology: Plate Tectonics  

NSDL National Science Digital Library

This National Park Service (NPS) site provides links to geology field notes providing information about National Parks, National Monuments, and National Recreation Areas that have to do with plate tectonics. The site also has illustrations and descriptions of different plate boundaries. The parks are divided into categories depending on which type of plate boundary they are located on. This includes divergent boundaries(active and ancient), convergent boundaries (ocean-ocean, continent-continent, continent-ocean), transform faults, hot spots, and accreted terrains. Parks referenced include Virgin Islands National Park, Florissant Fossil Beds National Monument, Hawaii Volcanoes National Park, and many more.

330

Second trimester maternal plasma levels of cytokines IL-1Ra, Il-6 and IL-10 and preterm birth  

PubMed Central

Objective To examine the interaction of the cytokines interleukin-1 receptor antagonist (IL)-1Ra, IL-6 and IL-10 to predict preterm birth (PTB) in pregnant Hispanic women (n = 470). Study Design In this prospective study, demographic data were obtained prenatally and birth outcome data were obtained from the medical chart. Cytokines were measured from plasma obtained at 22 to 24 weeks gestation. Data analysis utilized logistic regression. Result PTB was predicted by level of IL-1Ra (odds ratio (OR) = 2.55; 95% confidence interval (CI) = 1.24, 5.24). The interaction between IL-1Ra and IL-6 and between IL-1Ra and IL-10 was significant (Wald = 4.01, P = 0.04 and Wald = 8.84, P<0.003, respectively) and was also predictive of PTB. As IL-1Ra levels increased while IL-10 levels were low, the probability of PTB greatly increased. Conclusion The interactions of select cytokines and cytokine receptor antagonists were associated with PTB. Future research should focus on the changes in cytokines during pregnancy to identify critical periods of change, and examine predictors of the cytokine response. PMID:22460542

Ruiz, RJ; Jallo, N; Murphey, C; Marti, CN; Godbold, E; Pickler, RH

2012-01-01

331

Euler-Lagrange Modeling of Vortex Interaction with a Particle-Laden Turbulent Boundary Layer  

NASA Astrophysics Data System (ADS)

Rotorcraft operation in austere environments can result in difficult operating conditions, particularly in the vicinity of sandy areas. The uplift of sediment by rotorcraft downwash, a phenomenon known as brownout, hinders pilot visual cues and may result in a potentially dangerous situation. Brownout is a complex multiphase flow problem that is not unique and depends on both the characteristics of the rotorcraft and the sediment. The lack of fundamental understanding constrains models and limits development of technologies that could mitigate the adverse effects of brownout. This provides the over-arching motivation of the current work focusing on models of particle-laden sediment beds. The particular focus of the current investigations is numerical modeling of near-surface fluid-particle interactions in turbulent boundary layers with and without coherent vortices superimposed on the background flow, that model rotorcraft downwash. The simulations are performed with two groups of particles having different densities both of which display strong vortex-particle interaction close to the source location. The simulations include cases with inter-particle collisions and gravitational settling. Particle effects on the fluid are ignored. The numerical simulations are performed using an Euler- Lagrange method in which a fractional-step approach is used for the fluid and with the particulate phase advanced using Discrete Particle Simulation. The objectives are to gain insight into the fluid-particle dynamics that influence transport near the bed by analyzing the competing effects of the vortices, inter-particle collisions, and gravity. Following the introduction of coherent vortices into the domain, the structures convect downstream, dissipate, and then recover to an equilibrium state with the boundary layer. The particle phase displays an analogous return to an equilibrium state as the vortices dissipate and the boundary layer recovers, though this recovery is slower than for the fluid and is sensitive to the particle response time. The effects of inter-particle collisions are relatively strong and apparent throughout the flow, being most effective in the boundary layer. Gravitational settling increases the particle concentration near the wall and consequently increase inter-particle collisions.

Morales, Fernando

332

IL22/IL-22R Pathway Induces Cell Survival in Human Glioblastoma Cells  

PubMed Central

Interleukin-22 (IL-22) is a member of the IL-10 cytokine family that binds to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2. IL-22R expression was initially characterized on epithelial cells, and plays an essential role in a number of inflammatory diseases. Recently, a functional receptor was detected on cancer cells such as hepatocarcinoma and lung carcinoma, but its presence was not reported in glioblastoma (GBM). Two GBM cell lines and 10 primary cell lines established from patients undergoing surgery for malignant GBM were used to investigate the expression of IL-22 and IL-22R by using quantitative RT-PCR, western blotting and confocal microscopy studies. The role of IL-22 in proliferation and survival of GBM cell lines was investigated in vitro by BrdU and ELISA cell death assays. We report herein that the two subunits of the IL-22R complex are expressed on human GBM cells. Their activation, depending on exogenous IL-22, induced antiapoptotic effect and cell proliferation. IL-22 treatment of GBM cells resulted in increased levels of phosphorylated Akt, STAT3 signaling protein and its downstream antiapoptotic protein Bcl-xL and decreased level of phosphorylated ERK1/2. In addition, IL-22R subunits were expressed in all the 10 tested primary cell lines established from GBM tumors. Our results showed that IL-22R is expressed on GBM established and primary cell lines. Depending on STAT3, ERK1/2 and PI3K/Akt pathways, IL-22 induced GBM cell survival. These data are consistent with a potential role of IL-22R in tumorigenesis of GBM. Since endogenous IL-22 was not detected in all studied GBM cells, we hypothesize that IL-22R could be activated by immune microenvironmental IL-22 producing cells. PMID:25793261

Akil, Hussein; Abbaci, Amazigh; Lalloué, Fabrice; Bessette, Barbara; Costes, Léa M. M.; Domballe, Linda; Charreau, Sandrine; Guilloteau, Karline; Karayan-Tapon, Lucie; Bernard, François-Xavier; Morel, Franck

2015-01-01

333

The interleukin (IL)-31/IL-31R axis contributes to tumor growth in human follicular lymphoma.  

PubMed

Interleukin (IL)-31A binds to an heterodimer composed of IL-31 receptor A (IL-31RA) and Oncostatin M Receptor (OSMR). The IL-31/IL-31R complex is involved in the pathogenesis of various skin diseases, including cutaneous T-cell lymphoma. No information is available on the relations between the IL-31/IL-31R complex and B-cell lymphoma. Here we have addressed this issue in follicular lymphoma (FL), a prototypic germinal center(GC)-derived B-cell malignancy. IL-31 enhanced primary FL cell proliferation through IL-31R-driven signal transducer and activator of transcription factor 1/3 (STAT1/3), extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt phosphorylation. In contrast, GC B cells did not signal to IL-31 in spite of IL-31R expression. GC B cells expressed predominantly the inhibitory short IL-31RA isoform, whereas FL cells expressed predominantly the long signaling isoform. Moreover, GC B cells lacked expression of other IL-31RA isoforms potentially involved in the signaling pathway. IL-31 protein expression was significantly higher in surface membrane than in cytosol of both FL and GC B cells. IL-31 was detected in plasma membrane microvesicles from both cell types but not released in soluble form in culture supernatants. IL-31 and IL-31RA expression was higher in lymph nodes from FL patients with grade IIIa compared with grade I/II, suggesting a paracrine and/or autocrine role of IL-31/IL-31RA complex in tumor progression through microvesicle shedding. PMID:25283844

Ferretti, E; Tripodo, C; Pagnan, G; Guarnotta, C; Marimpietri, D; Corrias, M V; Ribatti, D; Zupo, S; Fraternali-Orcioni, G; Ravetti, J L; Pistoia, V; Corcione, A

2015-04-01

334

Increased IL-21/IL-21R expression and its proinflammatory effects in autoimmune thyroid disease.  

PubMed

To determine the potential role of interleukin-21 (IL-21) / IL-21 receptor (IL-21R) in the pathogenesis of autoimmune thyroid disease (AITD) mainly known as Graves' disease (GD) and Hashimoto's thyroiditis (HT). IL-21 and IL-21R of peripheral blood samples and/or thyroid tissues from AITD patients and healthy controls were analyzed by ELISA, quantitative real-time polymerase chain reaction (qRT-PCR), flow cytometry and immunohistochemistry. In vitro, the mRNA and protein of inflammatory cytokines of cultured peripheral blood mononuclear cells (PBMCs) upon recombinant human IL-21 (rhIL-21) stimulation were detected. There was an increased serum concentration of IL-21 in untreated GD and HT patients, and IL-21(+)CD3(+)CD8(-)T cells were significantly increased in PBMCs of HT patients compared with healthy volunteers. The IL-21 mRNA expression in PBMCs increased dramatically in GD and HT patients, and marked augmentations of IL-21 and IL-21R mRNA in thyroid tissues of HT patients were observed. Immunohistochemical staining confirmed the expression of IL-21R protein in HT thyroid cells and lymphocytes. In vitro, PBMCs from GD cultured with rhIL-21 induced increased IL-17A but decreased IL-4 production, while from HT stimulated by rhIL-21 induced augmented production of IFN-?. In conclusion, the expression of IL-21 and IL-21R were up-regulated in AITD and may be involved in the pathogenesis of the disease through augmenting aberrant immune cascade. PMID:25647271

Guan, Li-Juan; Wang, Xuan; Meng, Shuai; Shi, Liang-Feng; Jiang, Wen-Juan; Xiao, Ling; Shi, Xiao-Hong; Xu, Jian; Zhang, Jin-An

2015-04-01

335

IL-17A inhibits the expansion of IL-17A-producing T cells in mice through "short-loop" inhibition via IL-17 receptor.  

PubMed

IL-23 and IL-17A regulate granulopoiesis through G-CSF, the main granulopoietic cytokine. IL-23 is secreted by activated macrophages and dendritic cells and promotes the expansion of three subsets of IL-17A-expressing neutrophil-regulatory T (Tn) cells; CD4(-)CD8(-)alphabeta(low), CD4(+)CD8(-)alphabeta(+) (Th17), and gammadelta(+) T cells. In this study, we investigate the effects of IL-17A on circulating neutrophil levels using IL-17R-deficient (Il17ra(-/-)) mice and Il17ra(-/-)Itgb2(-/-) mice that lack both IL-17R and all four beta(2) integrins. IL-17R deficiency conferred a reduction in neutrophil numbers and G-CSF levels, as did Ab blockade against IL-17A in wild-type mice. Bone marrow transplantation revealed that IL-17R expression on nonhemopoietic cells had the greatest effects on regulating blood neutrophil counts. Although circulating neutrophil numbers were reduced, IL-17A expression, secretion, and the number of IL-17A-producing Tn cells were elevated in Il17ra(-/-) and Il17ra(-/-)Itgb2(-/-) mice, suggesting a negative feedback effect through IL-17R. The negative regulation of IL-17A-producing T cells and IL-17A and IL-17F gene expression through the interactions of IL-17A or IL-17F with IL-17R was confirmed in splenocyte cultures in vitro. We conclude that IL-17A regulates blood neutrophil counts by inducing G-CSF production mainly in nonhemopoietic cells. IL-17A controls the expansion of IL-17A-producing Tn cell populations through IL-17R. PMID:18606690

Smith, Emily; Stark, Matthew A; Zarbock, Alexander; Burcin, Tracy L; Bruce, Anthony C; Vaswani, Devin; Foley, Patricia; Ley, Klaus

2008-07-15

336

Lichens of the U. S. national parks  

USGS Publications Warehouse

Over 26,100 records of lichens present in 144 U.S. national park units were assembled from various sources into a database and analyzed. Within these 144 park units 2,435 species and 375 genera are reported, representing 63% and 74% of the North American flora, respectively. The park units are located in 41 states and Washington, D.C. The average number of species in a park is 104, but the median is 60, indicating there are many parks with a small number of species and a few with high numbers. Isle Royale National Park has the most species, 611, and twelve parks have only one species reported. The number of records of lichens present ranged from one for 25 parks, to 1,623 for Isle Royale. Physcia aipolia is the most frequently observed species, being found in 65 parks. One fourth of the park units are classified cultural resource parks, while the remainder are considered natural resource parks. This study was based on 453 sources, including literature citations, park reports and collections in the University of Minnesota Herbarium. Copyright ?? 2005 by the American Bryological and Lichenological Society, Inc.

Bennett, J.P.; Wetmore, C.M.

2005-01-01

337

Bibliography of Doctor Chul Park  

NASA Technical Reports Server (NTRS)

This document contains a comprehensive bibliography of the published works, and a short biography, of Dr. Chul Park. The contents of this bibliography were compiled primarily from the NASA RECON data base. The RECON citations have been modified to appear in a uniform format with all other listed citations . These other citations were located by computer searches in the INSPEC, NTIS, COMPENDEX, and Chemical Abstracts data bases, as well as through the cooperation of Dr. Chul Park, and his associates in the Reacting Flow Environments Branch at NASA Ames Research Center. All citations are presented in an approximate reverse chronological order from the present date. This work was created to honor the occasion of Dr. Chul Park's retirement on December 14, 1994, after 27 years of distinguished government service at the NASA Ames Research Center.

Gochberg, Lawrence A.; Venkatapathy, Ethiraj; Park, Chul

1995-01-01

338

Amusement park injuries and deaths.  

PubMed

Media coverage of amusement park injuries has increased over the past several years, raising concern that amusement rides may be dangerous. Amusement park fatalities and increases in reported injuries have prompted proposed legislation to regulate the industry. Since 1979, the medical literature has published reports of 4 subdural hematomas, 4 internal carotid artery dissections, 2 vertebral artery dissections, 2 subarachnoid hemorrhages, 1 intraparenchymal hemorrhage, and 1 carotid artery thrombosis with stroke, all related to roller coaster rides. In this article, we review reports of amusement park injuries in the medical literature and Consumer Product Safety Commission data on the overall risk of injury. We also discuss the physics and the physiologic effects of roller coasters that may influence the type and severity of injuries. Although the risk of injury is low, emergency physicians are advised to include participation on thrill rides as part of their history, particularly when evaluating patients presenting with neurologic symptoms. PMID:11782733

Braksiek, Robert J; Roberts, David J

2002-01-01

339

IL-15 Deficient Tax Mice Reveal a Role for IL-1? in Tumor Immunity  

PubMed Central

IL-15 is recognized as a promising candidate for tumor immunotherapy and has been described as both a promoter of cancer and a promoter of anti-cancer immunity. IL-15 was discovered in cells transformed by HTLV-1, the etiologic agent of adult T cell leukemia/lymphoma (ATL) and the human retrovirus that carries the Tax oncogene. We have developed the TAX-LUC mouse model of ATL in which Tax expression drives both malignant transformation and luciferase expression, enabling non-invasive imaging of tumorigenesis in real time. To identify the role of IL-15 in spontaneous development of lymphoma in vivo, an IL-15?/? TAX-LUC strain was developed and examined. The absence of IL-15 resulted in aggressive tumor growth and accelerated mortality and demonstrated that IL-15 was not required for Tax-mediated lymphoma but was essential for anti-tumor immunity. Further analysis revealed a unique transcriptional profile in tumor cells that arise in the absence of IL-15 that included a significant increase in the expression of IL-1? and IL-1?-regulated cytokines. Moreover, anti-IL-1? antibodies and an IL-1 receptor antagonist (Anakinra) were used to interrogate the potential of IL-1? targeted therapies in this model. Taken together, these findings identify IL-15 and IL-1? as therapeutic targets in lymphoma. PMID:24416335

Rauch, Daniel A.; Harding, John C.; Ratner, Lee

2014-01-01

340

The Possible Role of the Novel Cytokines IL-35 and IL-37 in Inflammatory Bowel Disease  

PubMed Central

Interleukin- (IL-) 35 and IL-37 are newly discovered immune-suppressing cytokines. They have been described in inflammatory diseases such as collagen-induced arthritis and asthma. However, their expressions in inflammatory bowel disease (IBD) patients have not been yet explored. Our aim was to evaluate serum and inflamed mucosal levels in IBD patients. In 20 ulcerative colitis (UC) patients, 7 Crohn's disease (CD) patients, and 15 healthy subjects, cytokine levels in serum were determined using ELISA and mucosal expression studies were performed by immunohistochemistry, quantitative real-time PCR, and Western blot. The results showed that serums IL-35 and IL-37 levels were significantly decreased in UC and CD patients compared with healthy subjects. The cytokines levels correlated inversely with UC activity. IL-35 was expressed in infiltrating immune cells while IL-37 in intestinal epithelial cells as well as inflammatory cells. IBD patients had significantly higher Ebi3, p35 (two subunits of IL-35), and IL-37b gene expressions; IL-35 and IL-37 protein expressions were higher in IBD patients compared with controls. The study showed that serums IL-35 and IL-37 might be potentially novel biomarkers for IBD. Intestinal IL-35 and IL-37 proteins are upregulated, suggesting that regulating the expression of the two cytokines may provide a new possible target for the treatment of IBD. PMID:25214710

Li, Yanmei; Wang, Yanan; Liu, Ying; Wang, Yatian; Zuo, Xiuli; Li, Yanqing; Lu, Xuefeng

2014-01-01

341

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.  

PubMed Central

We demonstrate that purified interleukin 2 (IL-2) can directly upregulate IL-2 receptor expression on phytohemagglutinin-activated T lymphocytes maintained in culture until IL-2 receptor expression had markedly declined. The IL-2-induced increase in IL-2 receptor number is maximal within 12 hr, requires new RNA and protein synthesis, and is mediated by an interaction of ligand with the high-affinity receptors for IL-2. IL-2 stimulation results in increased accumulation of IL-2 receptor mRNA within 4 hr, while an increase in IL-2 receptor gene transcription is detected within 30 min in isolated nuclei. In addition, IL-2 incubation results in increased amounts of c-myc and transferrin receptor mRNA, but it does not augment levels of mRNA encoding the beta chain of the T-cell receptor for antigen. These results demonstrate that IL-2 can directly upregulate transcription and expression of its own receptor and, therefore, indicate that IL-2 may regulate IL-2-dependent immune responses, in part, by influencing the expression of IL-2 receptors. Images PMID:2987968

Depper, J M; Leonard, W J; Drogula, C; Krönke, M; Waldmann, T A; Greene, W C

1985-01-01

342

IL-33 Exacerbates Acute Kidney Injury  

PubMed Central

Inflammation contributes to the pathogenesis of acute kidney injury (AKI). IL-33 is a proinflammatory cytokine, but its role in AKI is unknown. Here we observed increased protein expression of full-length IL-33 in the kidney following induction of AKI with cisplatin. To determine whether IL-33 promotes injury, we administered soluble ST2 (sST2), a fusion protein that neutralizes IL-33 activity by acting as a decoy receptor. Compared with cisplatin-induced AKI in untreated mice, mice treated with sST2 had fewer CD4 T cells infiltrate the kidney, lower serum creatinine, and reduced acute tubular necrosis (ATN) and apoptosis. In contrast, administration of recombinant IL-33 (rIL-33) exacerbated cisplatin-induced AKI, measured by an increase in CD4 T cell infiltration, serum creatinine, ATN, and apoptosis; this did not occur in CD4-deficient mice, suggesting that CD4 T cells mediate the injurious effect of IL-33. Wildtype mice that received cisplatin and rIL-33 also had higher levels of the proinflammatory chemokine CXCL1, which CD T cells produce, in the kidney compared with CD4-deficient mice. Mice deficient in the CXCL1 receptor also had lower serum creatinine, ATN, and apoptosis than wildtype mice following cisplatin-induced AKI. Taken together, IL-33 promotes AKI through CD4 T cell-mediated production of CXCL1. These data suggest that inhibiting IL-33 or CXCL1 may have therapeutic potential in AKI. PMID:21949094

Akcay, Ali; Nguyen, Quocan; He, Zhibin; Turkmen, Kultigin; Won Lee, Dong; Hernando, Ana Andres; Altmann, Christopher; Toker, Aysun; Pacic, Arijana; Ljubanovic, Danica Galesic; Jani, Alkesh; Faubel, Sarah

2011-01-01

343

IL-21 Receptor Expression in Human Tendinopathy  

PubMed Central

The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role. Increasing evidence points toward an early inflammatory infiltrate and associated inflammatory cytokine production in human and animal models of tendon disease. The IL-21/IL-21R axis is a proinflammatory cytokine complex that has been associated with chronic inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease. This project aimed to investigate the role and expression of the cytokine/receptor pair IL-21/IL-21R in human tendinopathy. We found significantly elevated expression of IL-21 receptor message and protein in human tendon samples but found no convincing evidence of the presence of IL-21 at message or protein level. The level of expression of IL-21R message/protein in human tenocytes was significantly upregulated by proinflammatory cytokines (TNF?/IL-1?) in vitro. These findings demonstrate that IL-21R is present in early human tendinopathy mainly expressed by tenocytes and macrophages. Despite a lack of IL-21 expression, these data again suggest that early tendinopathy has an inflammatory/cytokine phenotype, which may provide novel translational targets in the treatment of tendinopathy. PMID:24757284

Campbell, Abigail L.; Smith, Nicola C.; Reilly, James H.; Kerr, Shauna C.; Leach, William J.; Fazzi, Umberto G.; Rooney, Brian P.; Murrell, George A. C.; Millar, Neal L.

2014-01-01

344

76 FR 72003 - Paterson Great Falls National Historical Park  

Federal Register 2010, 2011, 2012, 2013, 2014

...1843-SZM] Paterson Great Falls National Historical Park AGENCY: National Park Service...to donate-- (aa) the Great Falls State Park, including facilities for...bb) any portion of the Great Falls State Park agreed to between the...

2011-11-21

345

76 FR 70483 - Gettysburg National Military Park Advisory Commission  

Federal Register 2010, 2011, 2012, 2013, 2014

...Operational Updates on Park Activities which will...Landscape Rehabilitation, Park Projects, FY12 Appropriations and the Citizens Open...ask questions on any park activity. [[Page...Superintendent, Gettysburg National Military Park,...

2011-11-14

346

75 FR 64148 - General Regulation: National Park System  

Federal Register 2010, 2011, 2012, 2013, 2014

...Mountains National Park, Tennessee; Grand Canyon National Park, Arizona; Everglades National Park, Florida; and Hawaii Volcanoes National Parks, Hawaii--preserve nature's many and varied gifts to the Nation. The other two-thirds of the...

2010-10-19

347

36 CFR 7.56 - Acadia National Park.  

Code of Federal Regulations, 2011 CFR

...2011-07-01 2011-07-01 false Acadia National Park. 7.56 Section 7.56 Parks, Forests...INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.56 Acadia National Park. (a) Designated Snowmobile...

2011-07-01

348

36 CFR 7.56 - Acadia National Park.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 2010-07-01 false Acadia National Park. 7.56 Section 7.56 Parks, Forests...INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.56 Acadia National Park. (a) Designated Snowmobile...

2010-07-01

349

36 CFR 7.56 - Acadia National Park.  

Code of Federal Regulations, 2013 CFR

...2013-07-01 2013-07-01 false Acadia National Park. 7.56 Section 7.56 Parks, Forests...INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.56 Acadia National Park. (a) Designated Snowmobile...

2013-07-01

350

36 CFR 7.56 - Acadia National Park.  

Code of Federal Regulations, 2014 CFR

...2014-07-01 2014-07-01 false Acadia National Park. 7.56 Section 7.56 Parks, Forests...INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.56 Acadia National Park. (a) Designated Snowmobile...

2014-07-01

351

36 CFR 7.56 - Acadia National Park.  

Code of Federal Regulations, 2012 CFR

...2012-07-01 2012-07-01 false Acadia National Park. 7.56 Section 7.56 Parks, Forests...INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.56 Acadia National Park. (a) Designated Snowmobile...

2012-07-01

352

In vitro responsiveness to IL-18 in combination with IL-12 or IL-2 by PBMC from patients with bronchial asthma and atopic dermatitis.  

PubMed

Interleukin (IL)-18 is a proinflammatory cytokine and is now recognized as an important regulator of both helper T cells (Th) 1 and 2 cytokine production. An increased IL-18 secretion has been reported in patients with allergic disorders. It is predominantly produced by activated macrophages, and synergizes with IL-12 and IL-2 to induce IFN-gamma synthesis, thereby promoting Th1 cytokine response. Paradoxically, IL-18, by itself, strongly induces immunoglobulin (Ig) E and allergic inflammation, indicating a role for IL-18 in promoting Th2 response. We investigated the inducing effect in vitro of combining IL-18 and Il-12 or Il-2 on Th1- and Th2-type cytokines production by peripheral blood mononuclear cells (PBMC) from patients with allergic diseases. PBMC derived from 44 allergic patients [23 bronchial asthma (BA) and 21 atopic dermatitis (AD)] and 20 healthy controls were cultured with IL-18 in the presence of phytohemagglutinin (PHA) and IL-12 or IL-2. The levels of IFN-gamma, IL-13, and IL-4 in the culture supernatants were measured using enzymatic immunoassaying. IFN-gamma production was detected in all cultures from nonallergic controls stimulated with IL-18 in the presence of IL-12; however, the results for five BA patients and five AD patients were under the detection limit for IFN-gamma. In collaboration with IL-2, IL-18 was able to induce IFN-gamma production by PBMCs from all nonallergic controls and all allergic patients, with the exception of one AD patient. Synergistic induction of IL-13 production was found in cultures with IL-18 + IL-2, and the IL-13 induction was significantly increased in BA patients when compared with that in nonallergic controls (P = 0.006). The stimulation by IL-18, even in combination with IL-2, failed to induce IL-4 production by PBMC from both nonallergic controls and allergic patients. Although the induction of IFN-gamma by IL-18 + IL-12 was impaired in around a quarter of the allergic patients, the impairment of the IFN-gamma production was completely restored by IL-2 in the presence of IL-18. Thus, IL-18 enhances IFN-gamma production through an IL-12-dependent pathway and exhibits synergism when combined with IL-2 in terms of enhanced IL-13 and IFN-gamma production, suggesting the involvement of IL-18/IL-12/IL-2 pathway in modulating Th1/Th2 cytokine response. PMID:15093553

El-Mezayen, R E H; Matsumoto, T

2004-04-01

353

IL-23/IL-27 Ratio in Peripheral Blood of Patients with Breast Cancer  

PubMed Central

Background: Interleukin (IL)-23 and IL-27 are two IL-12-related cytokines which their function may dramatically influence the inflammatory response to tumor development. IL-12 and IL-27 seem to have antagonistic roles with IL-23 in tumor site. In this study, IL-23 and IL-27 mRNA expressions were analyzed in peripheral blood of patients with breast cancer and healthy volunteers using quantitative real-time PCR. Methods: Peripheral blood samples were collected from 50 women with breast cancer and 50 healthy ones. The total RNA was extracted from peripheral blood after lysis with ammonium chloride and TRizol reagent and the cDNA was synthesized. The expression of IL-23 and IL-27 gene transcripts was determined with real-time polymerase chain reaction (qRT-PCR) using Syber Green PCR Master Mix. Results: It is found that IL-23 and IL-27 transcripts had significantly higher expression in peripheral blood of patients compared with the healthy controls. The ratio of IL-23 transcript expression to IL-27 was 3.4 fold lower in the studied patients compared with the normal individuals. Conclusion: It is concluded that the over expression of IL-23 and IL-27 gene transcript in peripheral blood of breast cancer patients may be an immune response against tumor development and the inflammatory response plays a critical role in tumor development via up regulating the corresponding cytokines. However, the IL-23/IL-27 ratio may play an important role in cytokine-based immunotherapy against cancer. Further research should be carried out to assess these cytokines in a larger sample size. . PMID:25031487

Khodadadi, Ali; Razmkhah, Mahboobeh; Eskandari, Ali-Reza; Hosseini, Ahmad; Habibagahi, Mojtaba; Ghaderi, Abbas; Jaberipour, Mansooreh

2014-01-01

354

IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells.  

PubMed

Osteosarcoma (OS) is the most common human primary malignant bone tumor in children and young adults with poor prognosis because of their high metastatic potential. Identification of key factors that could regulate the aggressive biologic behavior of OS, particularly with respect to metastasis, would be necessary if significant improvements in therapeutic outcome are to occur. In this study, we carefully evaluated the potential role of IL-17A/IL-17RA interaction in metastasis of OS. We found that serum IL-17A was higher in OS patients with metastasis and was associated with their clinical stage. The elevated expression of IL-17RA was observed in tumor tissue from OS patients with metastasis. Of note, we showed that IL-17A could promote the metastasis of U-2 OS cells which expression high IL-17RA, but not MG63 cells which expression low IL-17RA. Further, we revealed that downregulation of IL-17RA in U-2 cells could abrogated the enhanced metastasis induced by IL-17A, while upregulation of IL-17RA in MG63 cells could elevate their response to IL-17A and exerted enhanced metastasis. We observed that IL-17A/IL-17RA interaction promoted the expression of VEGF, MMP9 and CXCR4 in OS cells, which might partly explain the enhanced metastasis of OS cells. Furthermore, we showed that Stat3 activity was crucial for IL-17A/IL-17RA interaction to promote OS metastasis. Finally, we confirmed that IL-17A/IL-17RA interaction promoted the metastasis of OS in nude mice. Our findings might provide a mechanistic explanation for metastasis of OS in vivo, and suggested that targeting IL-17A signaling was a novel promising strategy to treat patients with OS. PMID:23192273

Wang, Mingmin; Wang, Luanqiu; Ren, Tao; Xu, Lin; Wen, Zhenke

2013-02-01

355

HLA-DQ2-restricted gluten-reactive T cells produce IL21 but not IL17 or IL22  

Microsoft Academic Search

We have analyzed the production of the effector cytokines interleukin (IL)-17, IL-21, and IL-22 in gluten-reactive CD4+ T cells of celiac disease patients, either cultured from small intestinal biopsies or isolated from peripheral blood after an oral gluten challenge. Combining intracellular cytokine staining with DQ2-?-II gliadin peptide tetramer staining of intestinal polyclonal T-cell lines, we found that gluten-specific T cells

M Bodd; M Ráki; S Tollefsen; L E Fallang; E Bergseng; K E A Lundin; L M Sollid

2010-01-01

356

IL-15.IL-15R? complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells  

PubMed Central

Interleukin (IL)-15 and its specific receptor chain, IL-15R?, support the development of various effector cells, including NK and CD8 T cells via a mechanism called trans-presentation. Whereas the dynamic of trans-presentation has been shown to involve the recycling of IL-15R? by presenting cells, the way responding cells integrate, or take advantage of this process has not been evaluated yet. To address this question, we set up a trans-presentation model using a membrane-bound IL-15.IL-15R? fusion protein, and found that IL-15 is detectable within responding cells following IL-15 trans-presentation. The role of the proteolytic cleavage of IL-15R? in this process was investigated by generating an uncleavable form of IL-15R?. We showed that IL-15 entry into responding cells necessitates the cleavage of IL-15.IL-15R? complex from the surface of IL-15 presenting cells, and observed that IL-15R? cleavage is associated with a decrease of the duration of Stat5 signaling. Once separated from presenting cells, responding cells are able to recycle IL-15.IL-15R? complexes via intracellular compartments, for residual proliferation in a time-limited manner. These studies define an unprecedented cytokine pathway in which the IL-15.IL-15R? complex cleaved from presenting cells allows responding cells to internalize, store and use IL-15.IL-15R? complex for their own proliferation and survival. PMID:24912180

Tamzalit, Fella; Barbieux, Isabelle; Plet, Ariane; Heim, Julie; Nedellec, Steven; Morisseau, Sébastien; Jacques, Yannick; Mortier, Erwan

2014-01-01

357

Maturing dendritic cells are an important source of IL29 and IL20 that may cooperatively increase the innate immunity of keratinocytes  

Microsoft Academic Search

IL-19, IL-20, IL-22, IL-24, IL-26, IL- 28, and IL-29 are new members of the IL-10 inter- feron family. Monocytes are well-known sources of IL-19, IL-20, and IL-24. We demonstrated here that monocytes also expressed IL-29, and monocyte dif- ferentiation into macrophages (M) or dendritic cells (DCs) strongly changed their production capacity of these cytokines. Maturation of DCs with bacterial stimuli

Kerstin Wolk; Katrin Witte; Ellen Witte; Susanna Proesch; Gundula Schulze-Tanzil; Katarzyna Nasilowska; John Thilo; Khusru Asadullah; Wolfram Sterry; Hans-Dieter Volk; Robert Sabat

2008-01-01

358

Parking & Transportation Department RESIDENT -PERSONAL INFORMATION  

E-print Network

Parking & Transportation Department RESIDENT - PERSONAL INFORMATION Date know if you are interested in: Public Transportation Car Pool Van Pool _____________________________________________________________________________________ Please be sure to contact the Parking & Transportation Department with any changes to your information, i

Oliver, Douglas L.

359

City of New York Parks & Recreation  

NSDL National Science Digital Library

New York City's Department of Parks & Recreation oversees 29,000 acres of land, and more than 1,700 parks, playgrounds, and recreation facilities located throughout the five boroughs. Their website provides a great starting point for a virtual visit undaunted by weather. Take a virtual tour along the Bronx River, watch video clips from "It's My Park" (also aired every weekday at 11:00 a.m. on NYC life (channel 25)), and browse the photo gallery, which includes selections from the Parks Photo Archive, dating back to 1856, and the Parks' Flickr Group, with visitor-contributed photos. There are also seasonal features: for February, Black History Month, there's an events listing, an inventory of permanent sculptures honoring African-Americans in the Parks, African American Namesake Parks, and a photo gallery entitled The African American Experience. And of course, there's a Groundhog Day page, presenting the history of weather prediction by the rodent in the NYC Parks.

360

Exact and efficient calculation of Lagrange multipliers in constrained biological polymers: Proteins and nucleic acids as example cases  

E-print Network

In order to accelerate molecular dynamics simulations, it is very common to impose holonomic constraints on their hardest degrees of freedom. In this way, the time step used to integrate the equations of motion can be increased, thus allowing, in principle, to reach longer total simulation times. The imposition of such constraints results in an aditional set of Nc equations (the equations of constraint) and unknowns (their associated Lagrange multipliers), that must be solved in one way or another at each time step of the dynamics. In this work it is shown that, due to the essentially linear structure of typical biological polymers, such as nucleic acids or proteins, the algebraic equations that need to be solved involve a matrix which is banded if the constraints are indexed in a clever way. This allows to obtain the Lagrange multipliers through a non-iterative procedure, which can be considered exact up to machine precision, and which takes O(Nc) operations, instead of the usual O(Nc3) for generic molecular...

García-Risueńo, Pablo; Alonso, José Luis

2011-01-01

361

Everglades National Park Including Biscayne National Park. Activity Book.  

ERIC Educational Resources Information Center

Intended to help elementary school children learn about the resources of the Everglades and Biscayne National Parks, this activity book includes information, puzzles, games, and quizzes. The booklet deals with concepts related to: (1) the seasons; (2) fire ecology; (3) water; (4) fish; (5) mammals; (6) mosquitos; (7) birds; (8) venomous snakes;…

Ruehrwein, Dick

362

The equations of Lagrange for a continuous deformable body with rigid body degrees of freedom, written in a momentum based formulation  

NASA Astrophysics Data System (ADS)

The present paper is concerned with Lagrange's Equations, applied to a deformable body in the presence of rigid body degrees of freedom. The Lagrange description of Continuum Mechanics is used. An exact version of the Equations is derived first. This version, which represents an identical extension of the Fundamental Law of Dynamics, does involve the idea of virtual motions. The virtual motion is described in the framework of the Ritz-Ansatz, but our derivation does not make use of D'Alemberts principle, the principle of virtual work, or variational principles. From the exact version, by involving arguments related to the Galerkin approximation technique, we derive an approximate Ritz type version of Lagrange's Equations. This approximate version coincides with the traditional one, which is based on the notion of kinetic energy. However, since our derivation stems from the Fundamental Law of Dynamics, we have at our disposal an alternative formulation, which is based on the notion of local momentum. This momentum based version, which is the main topic of the present contribution, can be used for the purpose of performing independent checks of the energy based version of Lagrange's Equations. The momentum based version also clarifies that and how certain terms in the energy based version do cancel out. The momentum based version is worked out in the framework of the Floating Frame of Reference Formulation of Multibody Dynamics. Explicit formulas for the single terms of Lagrange's Equations are derived for the translational, rotational and flexible degrees of freedom of the deformable body, respectively. Corresponding Lagrange's Equations are explained in the light of the relations of Balance of Total Momentum, Balance of Total Moment of Momentum, of the Mean Stress Theorem and the notion of Virial of Forces. An embedding into the literature is given.

Irschik, H.; Krommer, M.; Nader, M.; Vetyukov, Y.; von Garssen, H.-G.

2015-01-01

363

Chlamydia trachomatis mouse pneumonitis lung infection in IL-18 and IL-12 knockout mice: IL-12 is dominant over IL-18 for protective immunity.  

PubMed Central

BACKGROUND: Interferon (IFN)-gamma is a key to protective immunity against a variety of intracellular bacterial infections, including Chlamydia trachomatis. Interleukin (IL)-18, a recently identified Th1 cytokine, together with IL-12 is a strong stimulator for IFN-gamma production. We investigated the relative roles of IL-18 and IL- 12 in protective immunity to C. trachomatis mouse pneumonitis (MoPn) infection using gene knockout (KO) and wild-type (WT) mice. MATERIALS AND METHODS: Mice were intranasally infected with C. trachomatis MoPn and protective immunity was assessed among groups of mice by daily body weight changes, lung growth of MoPn, and histopathological appearances at day 10 postinfection. The corresponding immune responses for each group of mice at the same postinfection time point were evaluated by measuring antigen-specific antibody isotype responses and cytokine profiles. RESULTS: Our results showed that IL-18 deficiency had little or no influence on clearance of MoPn from the lung, although KO mice exhibited slightly more severe inflammatory reactions in lung tissues, as well as reduced systemic and local IFN-gamma production, compared with WT mice. Results with IL-18 KO mice were in sharp contrast to those observed with IL-12 KO mice that showed substantially reduced clearance of MoPn from the lungs, substantial reductions of antigen-specific systemic and lung IFN-gamma production, decreased ratio of MoPn-specific immunoglobulin G (IgG)2a/IgG1, and severe pathological changes in the lung with extensive polymorphonuclear, instead of mononuclear, cell infiltration. Exogenous IL-12 or IL-18 was able to increase IFN-gamma production in IL-18 KO mice; whereas, only exogenous IL-12, but not IL-18, enhanced IFN-gamma production in IL-12 KO mice. Caspase-1 is the key protease for activation of IL-18 precursor into the bioactive form, and caspase-1 KO mice also displayed similar bacterial clearance and body weight loss to that in WT mice at early stages of MoPn infection. This further confirmed that IL-18 was not essential for host defense against chlamydia infection. CONCLUSIONS: These results suggest that IL-12, rather than IL-18, plays the dominant role in the development of protective immunity against chlamydia lung infection, although both cytokines are involved in the in vivo regulation of IFN-gamma production. PMID:10997341

Lu, H.; Yang, X.; Takeda, K.; Zhang, D.; Fan, Y.; Luo, M.; Shen, C.; Wang, S.; Akira, S.; Brunham, R. C.

2000-01-01

364

The Floral Park Traverse, Glacier National Park Jen poses with Hidden Lake in the background.  

E-print Network

The Floral Park Traverse, Glacier National Park Jen poses with Hidden Lake in the background to Logan Pass) into Floral Park, where we had lunch. Me with Sperry Glacier and Gunsight Mountain on viewer along Avalanche Lake basin to the distant peaks in the north of the Park. It was beautiful off

Bardsley, John

365

Smart Parking Management Field Test: A Bay Area Rapid Transit (BART) District Parking Demonstration  

Microsoft Academic Search

In almost every major city in the U.S. and internationally, parking problems are ubiquitous. It is well known that the limited availability of parking contributes to roadway congestion, air pollution, and driver frustration and that the cost of expanding traditional parking capacity is frequently prohibitive. However, less research has addressed the effect of insufficient parking at transit stations on transit

Susan Shaheen

2005-01-01

366

Light Stripe Projection based Parking Space Detection for Intelligent Parking Assist System  

Microsoft Academic Search

This paper proposes a novel light stripe projection based free parking space recognition method in order to overcome the common drawbacks of existing vision based target parking position designation methods in dark indoor parking site. 3D information of parking site is recognized by light stripe projection method. By analyzing the 3D information, system can recognize discontinuous points, pivot, and opposite-site

Ho Gi Jung; Dong Suk Kim; Pal Joo Yoon; Jaihie Kim

2007-01-01

367

Welcome to Diamond Light Source Parking Visitors can park outside Diamond  

E-print Network

Welcome to Diamond Light Source Parking ­ Visitors can park outside Diamond House, or if that is full, in the Visitor car park. Users should park around the ring. On Arrival ­ Diamond does not have 8500). Then take a seat 2 and wait for your Diamond contact to collect you. Users ­ Fast track users

Crowther, Paul

368

An exploration of the relationship between use of parks and access, park appeal, and communication effectiveness  

E-print Network

as four objective distances from household to nearest park using both Euclidian and Network measures, and by subjective self-reported measures of ability to access parks on foot or by bicycle. Appeal is concerned with the influence of parks? perceived... Statistics for Network ?, ?, ? and 1 Mile ....................................................... 66 Table 4.3 Access on Foot or By Bicycle and Park User Simple Logistic Statistics...

Walker, Jamie Rae

2009-05-15

369

University of Aberdeen Car Parking Policy -v2 0.docx University of Aberdeen Car Parking Policy  

E-print Network

University of Aberdeen Car Parking Policy - v2 0.docx University of Aberdeen Car Parking Policy 1.0 Why have a car parking policy? The University of Aberdeen is aware of the importance of corporate. The University has developed to such an extent that its current car park capacity is not sufficient to provide

Levi, Ran

370

77 FR 75254 - List of Units of the National Park System Exempt From the Provisions of the National Parks Air...  

Federal Register 2010, 2011, 2012, 2013, 2014

...annually. Exempt parks are as follows: Big Bend National Park, TX Black Canyon of the Gunnison National Park, CO Capulin Volcano National Monument, NM Carlsbad Caverns National Park, NM Casa Grande Ruins National Monument, AZ Coronado National...

2012-12-19

371

75 FR 3488 - Acadia National Park; Bar Harbor, ME; Acadia National Park Advisory Commission; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013, 2014

...OF THE INTERIOR National Park Service Acadia National Park; Bar Harbor, ME; Acadia National Park Advisory Commission; Notice of Meeting...C. App. 1, Sec. 10), that the Acadia National Park Advisory Commission will hold a...

2010-01-21

372

Geology Fieldnotes: Capitol Reef National Park, Utah  

NSDL National Science Digital Library

This Capitol Reef National Park site contains park geology information, park maps, photographs, visitor information, and a teacher feature (resources for teaching geology with National Park examples). Geologic data includes descriptions of the Waterpocket Fold, a monocline formed in the Laramide Orogeny and made of sedimentary rock. Also covered is erosion, and details about the Cathedral Valley outcrop of gypsum. This formation is Permian to Cretaceous in age (270-80 million years old).

373

Acadia National Park - Nature and Science  

NSDL National Science Digital Library

This National Park Service (NPS) website highlights the natural resources of Acadia National Park. Resources discussed include animals (amphibians, birds and fish), plants (ferns, freshwater plants, grasses, mosses, liverworts and wildflowers), environmental factors (fire regime, pests, nonnative species, weather, water quality and air quality), and natural features of the park (beaches, coastline, forests, geologic formations, intertidal and subtidal zones, mountains, and wetlands). There are related documents about the park's air and water quality available to download.

374

Nature and Science at Canyonlands National Park  

NSDL National Science Digital Library

This National Park Service (NPS) website highlights the environment and ecosystems found in Canyonlands National Park. Topics include animals in the park (amphibians, reptiles, birds, fish and mammals), plant life (cacti, grasses, lichens, mosses, liverworts, trees, shrubs and wildflowers), environmental factors (air quality, invasive species, endangered fish, noise pollution, peregrine falcons and bighorn sheep), and natural features (deserts, pools, rivers and stream, geology). Links are provided to downloadable brochures and reports on park research activities and additional information on wildlife and plants.

375

Geology Fieldnotes: Grand Canyon National Park, Arizona  

NSDL National Science Digital Library

Visitors can access park geology information, photographs, related links, visitor information, multimedia resources, and resources for teaching geology with National Park examples. The park geology section discusses the Grand Canyon's geologic history, structural geology, and features a question-and-answer section about the canyon. The history of the canyon as a park and environmental issues surrounding it are also discussed. A geologic cross section of the canyon showing the various rock layers is included.

376

Urban Parks: The Value of Small Urban Parks, Plazas and Other Outdoor Spaces  

E-print Network

park can be as small as a single house lot. Some of the very best urban parks in America are smaller than 100 x 100 feet. The best size depends on the location of the park and its design. Design is what makes a park great. A well-designed park... social capital can form, and small, urban parks are some of the very best spaces for this. The most urgent need in most cities * Associate Professors, Recreation, Park and Tourism Sciences, and Extension Specialists, The Texas A&M University System...

Shafer, Carl Scott; Jacob, John

2006-11-27

377

Tour of Park Geology: Hot Springs/Geothermal  

NSDL National Science Digital Library

This National Park Service (NPS) site provides links to National Parks with hot springs or geothermal activity. Where appropriate, links are provided to geology, visitor information, photographs, park maps, multimedia resources, geologic research, and additional links. Parks at this site include Hot Springs National Park, Lassen Volcano National Park, and more.

378

Privacy Impact Assessment OFEO Smithsonian Parking  

E-print Network

Privacy Impact Assessment OFEO Smithsonian Parking I. System Identification 1. IT System Name and Operations Monthly Parking Program run by Office of Protection Services. II. Privacy Assessment 1. What of the parking facility. All privacy related information contained within the database is relevant

Mathis, Wayne N.

379

Yellowstone National Park Online Slide File  

NSDL National Science Digital Library

This Yellowstone National Park website contains thousands of photographs of the Park. Images are organized by category including fire, thermal features, mammals, park structures, petrified trees, water, weather, scenics, and more. The photographs may be freely downloaded and more are being added through time.

Yellowstone National Park

380

TA's WANTED PINGREE PARK --SUMMER 2012  

E-print Network

TA's WANTED PINGREE PARK -- SUMMER 2012 NR 220 Natural Resources Ecology & Measurements-0710, rocky.coleman@colostate.edu Pingree Park NR 220 website - http://warnercnr.colostate.edu/pingree-park include, but are not limited to, criminal history, national sex offender search and motor vehicle history

381

NORTH PARK PHACELIA Conservation Action Plan  

E-print Network

NORTH PARK PHACELIA Conservation Action Plan 2011 Update North Park phacelia © Frank Weston Plant Panjabi, S. and B. Neely. 2011. North Park Phacelia Conservation Action Plan 2011 Update. Prepared for the National Fish and Wildlife Foundation. #12;3 I. Introduction This document identifies conservation

382

Parking, energy consumption and air pollution  

Microsoft Academic Search

This paper examines the impacts of different ways of parking on environmental effects, mainly vehicle emissions and air pollution. Vehicle energy consumption and the urban air quality at street level, related to location and design of parking establishments, need to be assessed and quantified. In addition, the indoor parking environment needs attention.This paper gives a description of a methodological approach

Paul G. Höglund

2004-01-01

383

Air pollution vulnerabiity of 22 midwestern parks  

Microsoft Academic Search

Air pollution increases in United States national parks as sources grow closer. As this happens, biota will be increasingly affected. Can it be determined in advance which parks will be more impacted by these air pollutants that others? This study of 22 park units in the midwestern United States attempted to answer this question. Plant lists were compiled for the

J. P. Bennett; N. Banerjee

1995-01-01

384

Development of advanced parking assistance system  

Microsoft Academic Search

This paper is the first to apply a multilevel driver assistance system in the development of a system to aid in the parking process. The development of this system is described within the iCAN (intelligent car navigation systems) project framework. A parking assistance system, parking administration system, and employed sensor system are described. The general architecture of a driver assistance

Massaki Wada; Kang Sup Yoon; Hideki Hashimoto

2003-01-01

385

Intelligent parking reservation service on the Internet  

Microsoft Academic Search

The described intelligent parking service is a part of an ITS (intelligent transportation system) in which parking facilities are conceived of in terms of various new functions which they can provide. This service does not simply manage the internal operations of a parking facility; rather, it is designed to be compatible with a wide range of aspects that are intertwined

K. Inaba; M. Shibui; T. Naganawa; M. Ogiwara; N. Yoshikai

2001-01-01

386

Alluvial Fan, Rocky Mountain National Park  

USGS Multimedia Gallery

The Alluvial Fan is a fan-shaped area of disturbance in Rocky Mountain National Park. It was created on July 15, 1982, when the earthen Lawn Lake Dam above the area gave way, flooding the Park and nearby town of Estes Park with more than 200 million gallons of water. Enormous boulders were displaced...

387

78 FR 24323 - National Park Week, 2013  

Federal Register 2010, 2011, 2012, 2013, 2014

...Proclamation 8961 of April 19, 2013 National Park Week, 2013 By the President of the United States...to be passed on. During National Park Week, we celebrate the wonders entrusted to...summon us to experience it firsthand. This week, the National Park Service will make...

2013-04-24

388

Urban parks: green spaces or green walls?  

Microsoft Academic Search

Parks as an urban landscape feature serve many functions as providers of passive and active recreation, environmental benefits, and wildlife habitat. The research presented herein explores the concept that urban parks may also function as a boundary landscape separating neighborhoods of distinct socioeconomic characteristics. When an urban park functions as a boundary, it impoverishes neighborhoods because it often leads to

William D. Solecki; Joan M. Welch

1995-01-01

389

Public Responses to National Park Environmental Policy.  

ERIC Educational Resources Information Center

This study investigates the behavioral responses of urban and semirural residents to a newly initiated Canadian national park environmental policy. The policy involved the reduction of service facilities within the park and a concomitant emphasis on the park's natural environment. (BT)

Smith, Geoffrey C.; Alderdice, David

1979-01-01

390

Natural fire management in National Parks  

Microsoft Academic Search

An evolving understanding of ecological processes, together with ambiguities in National Park Service policy, have led to multiple interpretations of the role of management in our large natural area National Parks. National Park Service management policies must be dynamic and responsive to changes in scientific knowledge and societal values. We propose that the principal aim of NPS resource management in

David J. Parsons; David M. Graber; James K. Agee; Jan W. van Wagtendonk

1986-01-01

391

Geology Fieldnotes: Acadia National Park, Maine  

NSDL National Science Digital Library

This National Park Service website highlights the geology of Acadia National Park. The story begins 500 million years ago, and goes through rock cycles, formations (Ellsworth, Bar Harbor, and Cranberry formations), intrusions, the Ice Age, glacial features, and development of shore patterns. There are area and park maps, photos, and links to additional information.

392

Seeking Mountains Field Trip Jasper National Park  

E-print Network

Seeking Mountains Field Trip Jasper National Park December 14-15, 2012 Jasper National Park of Jasper is one of only four communities located in a Canadian national park. We have arranged a special. The field trip includes as follows: a welcome reception at the Jasper Yellowhead Museum and Archives

MacMillan, Andrew

393

Geology Fieldnotes: Glacier National Park, Montana  

NSDL National Science Digital Library

Glaciers have played an important role in shaping this park, which is part of the Rocky Mountain chain and shares a border with Canada's Waterton Lakes National Park. Information on this site includes park geology, visitor information, photographs, and links to other resources.

394

Moon Park: A research and educational facility  

NASA Technical Reports Server (NTRS)

Moon Park has been proposed as an International Space Year (ISY) event for international cooperative efforts. Moon Park will serve as a terrestrial demonstration of a prototype lunar base and provide research and educational opportunities. The kind of data that can be obtained in the Moon Park facilities is examined taking the minimum number of lunar base residents as an example.

Kuriki, Kyoichi; Saito, Takao; Ogawa, Yukimasa

1992-01-01

395

Performance Modeling of Intelligent Car Parking Systems  

E-print Network

Performance Modeling of Intelligent Car Parking Systems K´aroly Farkas1,3 , G´abor Horv´ath1 Abstract. The performance analysis of the car parking process in a parking lot with various levels the average time necessary for the user to reach the desired destination, the amount of cars moving

Telek, MiklĂłs

396

Pro-Inflammatory Signaling by IL-10 and IL-22: Bad Habit Stirred Up by Interferons?  

PubMed Central

Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of transcription (STAT)-3 as dominant signaling mode. IL-10, formerly known as cytokine synthesis inhibitory factor, is key to deactivation of monocytes/macrophages and dendritic cells. Accordingly, pre-clinical studies document its anti-inflammatory capacity. However, the outcome of clinical trials assessing the therapeutic potential of IL-10 in prototypic inflammatory disorders has been disappointing. In contrast to IL-10, IL-22 acts primarily on non-leukocytic cells, in particular epithelial cells of intestine, skin, liver, and lung. STAT3-driven proliferation, anti-apoptosis, and anti-microbial tissue protection is regarded a principal function of IL-22 at host/environment interfaces. In this hypothesis article, hidden/underappreciated pro-inflammatory characteristics of IL-10 and IL-22 are outlined and related to cellular priming by type I interferon. It is tempting to speculate that an inherent inflammatory potential of IL-10 and IL-22 confines their usage in tissue protective therapy and beyond that determines in some patients efficacy of type I interferon treatment. PMID:23382730

Mühl, Heiko

2013-01-01

397

Interleukin (IL)-18 Promotes the Development of Chronic Gastrointestinal Helminth Infection by Downregulating IL-13  

E-print Network

Expulsion of the gastrointestinal nematode Trichuris muris is mediated by a T helper (Th) 2 type response involving interleukin (IL)-4 and IL-13. Here we show that Th1 response–associated susceptibility involves prior activation of IL-18 and caspase-1 followed by IL-12 and interferon (IFN)- ? in the intestine. IL-18–deficient mice are highly resistant to chronic T. muris infection and in vivo treatment of normal mice with recombinant (r)IL-18 suppresses IL-13 and IL-4 secretion but does not affect IFN-?. In vivo treatment of T. muris–infected IFN-?–deficient mice with rIL-18 demonstrated that the inhibitory effect of IL-18 on IL-13 secretion is independent of IFN-?. Hence, IL-18 does not function as an IFN-?–inducing cytokine during chronic T. muris infection but rather as a direct regulator of Th2 cytokines. These results provide the first demonstration of the critical role of IL-18 in regulating Th cell responses during gastrointestinal nematode infection. Key words: Th cell • cytokine • mucosa • nematode • regulation

398

IL7 potential function in pulmonary TB  

Microsoft Academic Search

The study aims to find some other functions of IL-7 in control TB and screen a new host marker in small groups of TB patients and controls to identify promising markers for large- scale testing. Real-time RT-PCR is used to evaluate the stability of IL-4 and IL-7 mRNA in the presence of Actinomycin D in whole blood from active TB

F. G. Pan; Y. Y. Zhao; W. Y. Han; C. J. Sun; L. C. Lei; X. Feng; C. T. Du; S. S. Liu; S. Zhu

2011-01-01

399

IL20: biological functions and clinical implications  

Microsoft Academic Search

Summary  IL-20 belongs to the IL-10 family and plays a role in skin inflammation and the development of hematopoietic cells. Little is known about its other biological functions and clinical implications, however. Updated information about IL-20, such as its identification, expression, receptors, signaling, biological activities, and potential clinical implications, is illustrated in this review based on our research and on data

Chi-Chen Wei; Yu-Hsiang Hsu; Hsing-Hui Li; Yo-Ching Wang; Mei-Yi Hsieh; Wei-Yu Chen; Chung-Hsi Hsing; Ming-Shi Chang

2006-01-01

400

Serum IL-1beta, sIL-2R, IL-6, IL-8 and TNF-alpha in schizophrenic patients, relation with symptomatology and responsiveness to risperidone treatment.  

PubMed Central

Activation of the inflammatory response system and varied levels of cytokines in acute schizophrenia have been suggested by recent studies. Psychopharmacologic agents can differentially effect cytokine production, which suggests that therapeutic function of neuroleptics may involve immunomodulation. The present study was carried out to examine: (i) serum concentrations of interleukin (IL)-1beta, soluble interleukin-2 receptor (sIL-2R), IL-6, IL-8 and tumour necrosis factor (TNF)-alpha in schizophrenic patients; (ii) their relation with psychopathological assessment; and (iii) the relation of the initial cytokine levels with responsiveness to risperidone therapy. Thirty-four drug-free schizophrenic patients with acute exacerbation and 23 age- and gender-matched healthy controls were recruited for this study. Psychopathological assessments at admission and throughout risperidone treatment for 60 days were recorded. Serum cytokine concentrations were determined with chemilumunescence assays. According to our results, serum IL-1beta, sIL-2R, IL-6, IL-8 and TNF-alpha concentrations adjusted for age, gender, body mass index and smoking were no different in patients with schizophrenia and controls and among subtypes of schizophrenia. However, the initial TNF-alpha concentrations had a significant effect on Brief Psychiatric Rating Scale and Scale Assessment of Positive Symptoms scores. The initial cytokine concentrations of the patients responsive to risperidone were not significantly different from those of non-responsive patients. The present study demonstrates that plasma levels of IL-1beta, sIL-2R, IL-6, IL-8 and TNF-alpha adjusted for confounding factors are not altered in drug-free schizophrenic patients at acute exacerbation. We suggest that, if cytokine production is altered in schizophrenia, these alterations may not be detectable in systemic circulation. According to our results, the therapeutic effect of risperidone is not related to basal levels of the aforementioned cytokines. However, serum TNF-alpha may contribute to symptomatology in schizophrenia PMID:11545247

Erba?ci, A B; Herken, H; Köylüoglu, O; Yilmaz, N; Tarakçioglu, M

2001-01-01

401

Impact of IL-18 on inflammation.  

PubMed

IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic cells, and activated T cells stimulated by LPS. It is an important regulator of both innate and acquired immune responses. IL-18 plays a central role in rheumatoid arthritis since the T cells and macrophages that invade the synovial. These finding support a role for IL-18 in inflammation, allergy and immune diseases. PMID:21382268

Tripodi, D; Maccauro, G; Anogeianaki, A; Castellani, M L; Pandolfi, F; Felaco, P; Toniato, E; De Lutiis, M A; Fulcheri, M; Tetč, S; Galzio, R; Salini, V; Caraffa, A; Antinolfi, P; Frydas, I; Sabatino, G; Shaik-Dasthagirisaheb, Y B

2011-01-01

402

IL-27 regulates IL-10 and IL-17 from CD4+ cells in non-healing Leishmania major infection1  

PubMed Central

Control of infection caused by Leishmania major requires the development of IFN-?+CD4+ lymphocytes for the induction of microbicidal activity in host macrophages. We recently reported on the inability of conventionally resistant C57BL/6 mice to successfully resolve infection by an isolate of L. major, despite a strong IFN-? response by the host. Susceptibility was caused by antigen-specific IL-10 from CD4+ cells that were also producing IFN-?. In the present studies, we have explored the role for IL-27 in the regulation of IL-10 from Th1 cells in Leishmaniasis. Cytokine analysis of CD4+ cells in the lesions and draining lymph nodes of infected IL-27R deficient (WSX-1-/-) mice revealed diminished IL-10 from IFN-?+ CD4+ cells, which was accompanied by a reduction in total IFN-?+ CD4+ cells and an increase in IL-4. Despite the inhibition of IL-10 from CD4+ cells, no significant change in parasite numbers was observed, due both to the shift in the Th1/Th2 balance and to residual levels of IL-10. Strikingly, infected WSX-1-/- mice developed more severe lesions that were associated with the appearance of IL-17+ CD4+ cells, demonstrating a function for IL-27 in blocking the development of inappropriate Th17 cells during L. major infection. The results demonstrate the pleiotropic effects that IL-27 has on L. major-driven Th1, Th2, and Th17 development, and reinforce its function as a key regulatory cytokine that controls the balance between immunity and pathology. PMID:19748991

Anderson, Charles F.; Stumhofer, Jason S.; Hunter, Christopher A.; Sacks, David

2009-01-01

403

DIPLOSTOMOSIS IN NORTH PARK, COLORADO  

Microsoft Academic Search

The life cycle of Diplostoinuni spathaceuni (Rudobfi 1819), as it exists in North Park, Colorado, is elucidated. California gulls (Larus californicus), common mergansers (Mergus merganser) and Forster's terns (Sterna forsteri) act as definitive hosts. Two species of water snails, Phvsa gvrina and Lvnzneae elodes, act as first intermediate hosts with seven species of fish as second intermediate hosts: brassy minnows

ROBERT B. DAVIES; WALTER T. BURKHARDE; CHARLES P. HIBLER

1973-01-01

404

University Park Campus EMERGENCY MANAGEMENT  

E-print Network

assistance to those with special needs. If a building or area evacuation is ordered by the emergency and inform others to do the same (follow Emergency Evacuation Plan Procedures). ·Call 9-1-1 from a safeWelcome To University Park Campus EMERGENCY MANAGEMENT www.emergencymanagement.psu.edu Emergency

Yener, Aylin

405

Egmont National Park, New Zealand  

NASA Technical Reports Server (NTRS)

The lush forests of Egmont National Park, on New Zealand's North Island, contrast with the pasturelands outside the circular park boundaries. The unique shape of the park results from its first protection in 1881, which specified that a forest reserve would extend in a 9.6 km radius from the summit of Mt. Taranaki (named Mt. Egmont by Captain Cook). The park covers about 33,500 hectares and Mt. Egmont stands at 2518 m. The volcano began forming 70,000 years ago, and last erupted in 1755. A series of montane habitats occur in procession up the flanks of the volcano-from rainforest, to shrubs, to alpine, and finally snow cover. Image STS110-726-6, was taken by Space Shuttle crewmembers on 9 April 2002 using a Hasselblad film camera. Image provided by the Earth Sciences and Image Analysis Laboratory at Johnson Space Center. Additional images taken by astronauts and cosmonauts can be viewed at the NASA-JSC Gateway to Astronaut Photography of Earth.

2002-01-01

406

Digital Rights Management Jaehong Park  

E-print Network

song to Bob for review § Alice doesn't want Chris to listen the song Chris Undesirable distribution leakage (e.x. intelligence community, health care) © Jaehong Park 2001 6 The DRM Origin n item à 106 to 108 recipients n Some leakage is acceptable or even desirable n Music, popular books

Sandhu, Ravi

407

Parking garage threats and countermeasures.  

PubMed

Preventing and dealing with crime in hospital parking facilities poses a serious challenge to administration and security. Multiple methods to effectively combat the threats are described by the author, but their implementation depends on how seriously a healthcare organization views its responsibility to provide a safe and secure environment for its staff, patients and visitors. PMID:15457923

Clark, Sam

2004-01-01

408

JOHNSON PARK RUTGERS GOLF COURSE  

E-print Network

JOHNSON PARK RUTGERS GOLF COURSE MITCHELL AVE TOOLANST HOES LN MARIONCT HOES LN W GATES AVE RIVER Lab Allen Hall Crosby Hall Judson HallMorrow Hall Buell Apartments Winkler HallThomas Hall Mattia Hall McCormick Hall Richardson Apartments Russell Apartments Johnson Apartments Waksman Greenhouse Civil

Hanson, Stephen José

409

National Park Glaciers Knowledge Center  

NSDL National Science Digital Library

This interactive resource explains what glaciers are, where they are found, how they form, and how they move. The types and parts of glaciers are discussed, as well as ice ages, the different types of landforms that may result from glaciation, and how scientists monitor glaciers. Examples from our national parks are also highlighted as case studies to illustrate how glaciers have created landscapes.

2005-08-01

410

Romanticism and American National Parks  

Microsoft Academic Search

The national park idea was conceived at a time when nature romanticism dominated Americans' sense of landscape aesthetics. Among the basic tenets of romantic philosophy discussed are the specific definitions of the picturesque and the sublime, importance of historical and romantic associations, role of emotional response to natural scenery, perception of God in nature, restorative powers of nature, and perceptions

Stanford E. Demars

1990-01-01

411

UV - RESEARCH TRIANGLE PARK NC  

EPA Science Inventory

Brewer 087 is located in Research Triangle Park NC, measuring ultraviolet solar radiation. Irradiance and column ozone are derived from this data. Ultraviolet solar radiation is measured with a Brewer Mark IV, single-monochrometer, spectrophotometer manufactured by SCI-TEC Instru...

412

Lake Manyara Park / Ngorongoro Highlands  

E-print Network

Olduvai Gorge Grumeti Game Reserve Lake Victoria Optional Extension: Rwanda Mountain Gorilla Trek h Safari­10: Serengeti National Park (Western Corridor ­ Grumeti) / Lake Victoria (B,L,D) Acacia woodland, fishing. Discoverlocalpeopleandcultureswith unique village and schoolvisitstoMto Wa Mbu andafishing villageonthe shoreofLakeVictoria. Activity

Shapiro, Benjamin

413

SmartParking: A Secure and Intelligent Parking System Using NOTICE  

Microsoft Academic Search

Parking is costly and limited in almost every major city in the world. Innovative parking systems for meeting near-term parking demand are needed. In this paper, we propose a novel, secure and intelligent parking system based on the concept and framework of NOTICE [WO07], a secure and privacy-aware architecture for the notification of traffic incidents. The proposed system, called SmartParking,

Gongjun Yan; Stephan Olariu; Michele C. Weigle; Mahmoud Abuelela

2008-01-01

414

Alternative Transportation and Travel Information Technologies: Monitoring Parking Lot Conditions Over Three Summer Seasons at Acadia National Park  

Microsoft Academic Search

Executive Summary: Parking lots are an important transportation re- source of Acadia National Park, as they provide visitors convenient access to some of the most desirable destinations within the park. However, during the summer, parking at some of the most popular destinations is in short supply. Drivers often park vehicles outside designated parking spaces within the lots and along the

John J. Daigle; Carol A. Zimmerman

415

IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells  

PubMed Central

Interleukin 4 (IL-4) can suppress delayed-type hypersensitivity reactions (DTHRs), including organ-specific autoimmune diseases in mice and humans. Despite the broadly documented antiinflammatory effect of IL-4, the underlying mode of action remains incompletely understood, as IL-4 also promotes IL-12 production by dendritic cells (DCs) and IFN-?–producing TH1 cells in vivo. Studying the impact of IL-4 on the polarization of human and mouse DCs, we found that IL-4 exerts opposing effects on the production of either IL-12 or IL-23. While promoting IL-12–producing capacity of DCs, IL-4 completely abrogates IL-23. Bone marrow chimeras proved that IL-4–mediated suppression of DTHRs relies on the signal transducer and activator of transcription 6 (STAT6)-dependent abrogation of IL-23 in antigen-presenting cells. Moreover, IL-4 therapy attenuated DTHRs by STAT6- and activating transcription factor 3 (ATF3)-dependent suppression of the IL-23/TH17 responses despite simultaneous enhancement of IL-12/TH1 responses. As IL-4 therapy also improves psoriasis in humans and suppresses IL-23/TH17 responses without blocking IL-12/TH1, selective IL-4–mediated IL-23/TH17 silencing is promising as treatment against harmful inflammation, while sparing the IL-12–dependent TH1 responses. PMID:25646481

Guenova, Emmanuella; Skabytska, Yuliya; Hoetzenecker, Wolfram; Sauer, Karin; Tham, Manuela; Kim, Kyu-Won; Park, Ji-Hyeon; Seo, Ji Hae; Ignatova, Desislava; Cozzio, Antonio; Levesque, Mitchell P.; Volz, Thomas; Köberle, Martin; Kaesler, Susanne; Thomas, Peter; Mailhammer, Reinhard; Ghoreschi, Kamran; Schäkel, Knut; Amarov, Boyko; Eichner, Martin; Schaller, Martin; Clark, Rachael A.; Röcken, Martin; Biedermann, Tilo

2015-01-01

416

IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells.  

PubMed

Interleukin 4 (IL-4) can suppress delayed-type hypersensitivity reactions (DTHRs), including organ-specific autoimmune diseases in mice and humans. Despite the broadly documented antiinflammatory effect of IL-4, the underlying mode of action remains incompletely understood, as IL-4 also promotes IL-12 production by dendritic cells (DCs) and IFN-?-producing TH1 cells in vivo. Studying the impact of IL-4 on the polarization of human and mouse DCs, we found that IL-4 exerts opposing effects on the production of either IL-12 or IL-23. While promoting IL-12-producing capacity of DCs, IL-4 completely abrogates IL-23. Bone marrow chimeras proved that IL-4-mediated suppression of DTHRs relies on the signal transducer and activator of transcription 6 (STAT6)-dependent abrogation of IL-23 in antigen-presenting cells. Moreover, IL-4 therapy attenuated DTHRs by STAT6- and activating transcription factor 3 (ATF3)-dependent suppression of the IL-23/TH17 responses despite simultaneous enhancement of IL-12/TH1 responses. As IL-4 therapy also improves psoriasis in humans and suppresses IL-23/TH17 responses without blocking IL-12/TH1, selective IL-4-mediated IL-23/TH17 silencing is promising as treatment against harmful inflammation, while sparing the IL-12-dependent TH1 responses. PMID:25646481

Guenova, Emmanuella; Skabytska, Yuliya; Hoetzenecker, Wolfram; Weindl, Günther; Sauer, Karin; Tham, Manuela; Kim, Kyu-Won; Park, Ji-Hyeon; Seo, Ji Hae; Ignatova, Desislava; Cozzio, Antonio; Levesque, Mitchell P; Volz, Thomas; Köberle, Martin; Kaesler, Susanne; Thomas, Peter; Mailhammer, Reinhard; Ghoreschi, Kamran; Schäkel, Knut; Amarov, Boyko; Eichner, Martin; Schaller, Martin; Clark, Rachael A; Röcken, Martin; Biedermann, Tilo

2015-02-17

417

Ethanol suppresses T cell proliferation without inhibiting interleukin 2 (IL2) production and IL2 receptor (IL2R) expression  

SciTech Connect

The effect of extended ethanol consumption of young C57BL/6J mice on T cell proliferation was studied. Splenic cells of young mice, fed with one of three different liquid diets for 6-7 weeks were cultured with Con A to assess T cell proliferation and production of IL2. Then, the proliferative response of splenic cells to PMA/ionomycin was assessed. Finally, Con A-activated T blast cells were assessed for their ability to express IL2R and to respond to IL2. The results showed that both Con A-induced mitogenesis and IL2-dependent proliferation of T cells from ethanol diet-fed mice were diminished as compared to that of maltose-substitute diet or standard liquid diet. However, the ability of T cells from ethanol diet-fed mice to produce IL2 and to express IL2R was not affected. Furthermore, the magnitude of ethanol-mediated suppression of T cell proliferation induced by PMA/ionomycin was comparable to that induced by Con A. These results taken together suggest that ethanol suppresses T cell proliferation by interfering with events following the IL2-IL2R interaction.

Chang, M.P.; Norman, D.C. (VA Medical Center, West Los Angeles, CA (United States) Univ. of California, Los Angeles (United States))

1991-03-11

418

Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1?, TNF? and oncostatin M.  

PubMed

Keratinocyte differentiation program leading to an organized epidermis plays a key role in maintaining the first line of defense of the skin. Epidermal integrity is regulated by a tight communication between keratinocytes and leucocytes, particularly under cytokine control. Imbalance of the cytokine network leads to inflammatory diseases such as psoriasis. Our attempt to model skin inflammation showed that the combination of IL-17A, IL-22, IL-1?, OSM and TNF? (Mix M5) synergistically increases chemokine and antimicrobial-peptide expression, recapitulating some features of psoriasis. Other characteristics of psoriasis are acanthosis and down-regulation of keratinocyte differentiation markers. Our aim was to characterize the specific roles of these cytokines on keratinocyte differentiation, and to compare with psoriatic lesion features. All cytokines decrease keratinocyte differentiation markers, but IL-22 and OSM were the most powerful, and the M5 strongly synergized the effects. In addition, IL-22 and OSM induced epidermal hyperplasia in vitro and M5 induced epidermal thickening and decreased differentiation marker expression in a mouse model, as observed in human psoriatic skin lesions. This study highlights the precise role of cytokines in the skin inflammatory response. IL-22 and OSM more specifically drive epidermal hyperplasia and differentiation loss while IL-1?, IL-17A and TNF? were more involved in the activation of innate immunity. PMID:25010647

Rabeony, Hanitriniaina; Petit-Paris, Isabelle; Garnier, Julien; Barrault, Christine; Pedretti, Nathalie; Guilloteau, Karline; Jegou, Jean-François; Guillet, Gérard; Huguier, Vincent; Lecron, Jean-Claude; Bernard, François-Xavier; Morel, Franck

2014-01-01

419

Inhibition of Keratinocyte Differentiation by the Synergistic Effect of IL-17A, IL-22, IL-1?, TNF? and Oncostatin M  

PubMed Central

Keratinocyte differentiation program leading to an organized epidermis plays a key role in maintaining the first line of defense of the skin. Epidermal integrity is regulated by a tight communication between keratinocytes and leucocytes, particularly under cytokine control. Imbalance of the cytokine network leads to inflammatory diseases such as psoriasis. Our attempt to model skin inflammation showed that the combination of IL-17A, IL-22, IL-1?, OSM and TNF? (Mix M5) synergistically increases chemokine and antimicrobial-peptide expression, recapitulating some features of psoriasis. Other characteristics of psoriasis are acanthosis and down-regulation of keratinocyte differentiation markers. Our aim was to characterize the specific roles of these cytokines on keratinocyte differentiation, and to compare with psoriatic lesion features. All cytokines decrease keratinocyte differentiation markers, but IL-22 and OSM were the most powerful, and the M5 strongly synergized the effects. In addition, IL-22 and OSM induced epidermal hyperplasia in vitro and M5 induced epidermal thickening and decreased differentiation marker expression in a mouse model, as observed in human psoriatic skin lesions. This study highlights the precise role of cytokines in the skin inflammatory response. IL-22 and OSM more specifically drive epidermal hyperplasia and differentiation loss while IL-1?, IL-17A and TNF? were more involved in the activation of innate immunity. PMID:25010647

Rabeony, Hanitriniaina; Petit-Paris, Isabelle; Garnier, Julien; Barrault, Christine; Pedretti, Nathalie; Guilloteau, Karline; Jegou, Jean-François; Guillet, Gérard; Huguier, Vincent; Lecron, Jean-Claude; Bernard, François-Xavier; Morel, Franck

2014-01-01

420

www.tau.ac.il/cenlib/ www.tau.ac.il/cenlib/wie  

E-print Network

, , . . , , . www.tau.ac.il/cenlib/ www.tau.ac.il/cenlib/wie ner/ " '-' 9:00-99:00 '-9:00 91:00 '-' 9:00-10:00 '-9:00 91:00 " www.tau.ac.il/soclib/ "- '-'-3:00 10:00 '-9:00 91:54 '-'- 3:00­ 10:00 '-9:00 91:54 - " http://medlib.tau.ac.il/heb rew

Shamir, Ron

421

Image guided thermal ablation of tumors increases the plasma level of IL-6 and IL-10  

PubMed Central

PURPOSE To identify changes in plasma cytokine levels following image-guided thermal ablation of human tumors and to identify the factors that independently predict changes in plasma cytokine levels. MATERIALS AND METHODS Whole blood samples were collected from 36 patients at 3 time points: pre-ablation, post-ablation (within 48 hours), and in follow-up (1–5 weeks after ablation). Plasma levels of IL-1a, IL-2, IL-6, IL-10 and TNFa were measured using a multiplex immunoassay. Univariate and multivariate analyses were performed using cytokine level as the dependent variable and sample collection, time, age, sex, primary diagnosis, metastatic status, ablation site, and ablation type as the independent variables. RESULTS There was a significant increase in the plasma level of IL-6 post-ablation when compared to pre-ablation (9.6+/?31 fold, p<0.002). IL-10 also showed a significant increase postablation (1.9 +/?2.8 fold, p<0.02). Plasma levels of IL-1a, IL-2, and TNFa were not significantly changed after ablation. Cryoablation resulted in the largest change in IL-6 level (>54 fold), while radiofrequency and microwave ablation showed 3.6 and 3.4-fold changes, respectively. Ablation of melanomas showed the largest change in IL-6 48 hours after ablation (92×), followed by ablation of kidney (26×), liver (8×), and lung (6×) cancers. Multivariate analysis revealed that ablation type (p<0.0003), and primary diagnosis (p<0.03) were independent predictors of changes to IL-6 following ablation. Age was the only independent predictor of IL-10 levels following ablation (p<0.019). CONCLUSION Image guided thermal ablation of tumors increases the plasma level of IL-6 and IL-10, without increasing the plasma level of IL-1a, IL-2, or TNFa. PMID:23582441

Erinjeri, Joseph P; Thomas, Contessa T; Samoila, Alaiksandra; Fleisher, Martin; Gonen, Mithat; Sofocleous, Constantinos T.; Thornton, Raymond H; Siegelbaum, Robert H.; Covey, Anne M.; Brody, Lynn A.; Alago, William; Maybody, Majid; Brown, Karen T.; Getrajdman, George; Solomon, Stephen B.

2014-01-01

422

Differential expression of interleukins IL13 and IL15 in normal ovarian tissue and ovarian carcinomas  

Microsoft Academic Search

Objective. To determine the temporal and spatial expression of interleukins (IL)-13 and IL-15 in ovarian carcinoma compared to normal ovarian tissue.Methods. Quantitative RT-PCR, ELISA and immunohistochemistry.Results. Q-RT-PCR, ELISA and immunohistochemical analysis indicates that IL-13 and IL-15 mRNA and protein are expressed in normal ovary at various phases of the menstrual cycle with immunoreactive proteins detected in granulosa\\/theca and luteal cells

Daylene Ripley; Brenda Shoup; Andrew Majewski; Nasser Chegini

2004-01-01

423

Effects of interleukin (IL)-17A and IL17F in human rheumatoid arthritis synoviocytes  

Microsoft Academic Search

Rheumatoid arthritis (RA) is a chronic inflammatory disease where the contribution of T cells is now supported by clinical results. Among the cytokines produced by T cells, interleukin (IL)-17A (previously known as IL-17) and IL-17F constitute the signature cytokines of the newly described Th17 T helper cell subset. While the effects of IL-17A on RA synoviocytes been well described, those

Arnaud Hot; Pierre Miossec

2011-01-01

424

Urban Parks: Volunteers and Civic Engagement  

E-print Network

&M University System. New Department of Recreation, Park and Tourism Sciences ? www.rpts.tamu.edu Adopt-A-Park ? Austin, Texas Through this program, citizen volunteers are involved in cleaning up parks and in other activities (http://www. ci.austin.tx... engagement is beneficial not only for citi- zens and park and recreation agencies, but for schools and businesses as well, and it can lead * Associate Professor and Extension Specialist in Recreation, Park and Tourism Sciences, The Texas A&M University...

Schuett, Michael A.

2007-03-02

425

IL-33: A Sheep in Wolf's Clothing?  

NSDL National Science Digital Library

Cytokines are soluble factors that regulate intercellular communication by binding to specific cell-surface receptors and activating cellular responses. A small subset of cytokines, however, has been recognized to act in an intracrine manner without being secreted. These molecules enter the nucleus and regulate gene transcription by binding nuclear coactivators or repressors. Interleukin-33 (IL-33), a cytokine with high sequence and structural similarity to IL-1 and IL-18, has now been identified as another member of this group of "double agents." The activity of IL-33, however, appears to be the opposite of other dual-activity molecules such as the proinflammatory molecules, IL-1? and HMBG1 (high-mobility group box 1). Soluble IL-33 binds the Toll-interleukin 1 (IL-1) receptor (TIR) domain-containing receptor ST2 and has T helper 2 (Th2) immunoregulatory activity. ST2 also inhibits the activity of Toll-like receptors (TLRs) by sequestering the TLR adaptor molecules MyD88 and Mal. The HMBG1 receptor pairs with TLRs and helps drive responses to infections, raising the possibility that ST2, acting as a coreceptor for TLRs, could modulate and perhaps limit immune responses to pathogens. The nuclear targets of IL-33 are still unknown, but the expression of IL-33 in inflamed tissues, its nuclear repressor activity, and the antagonistic properties of ST2 suggest that it could decrease inflammation, opposing the activity of factors like IL-1. If this holds true, IL-33 has potential as a novel therapeutic in autoimmune and inflammatory diseases.

Massimo Gadina (Queen's University Belfast; Centre for Cancer Research and Cell Biology REV)

2007-06-12

426

The Unique Functions of the Type-II IL-4 Receptor are revealed in IL-13Rż1-deficient mice  

Technology Transfer Automated Retrieval System (TEKTRAN)

The IL-4 receptor is a central mediator of Th2-mediated diseases and associates with either the common gamma chain (type-I IL-4R) or IL-13Ra1 (type-II IL-4R) to form two receptor complexes. Here, using IL-13Ra1-/- mice, we characterized the distinct functions of the type-II IL-4R. In contrast to IL-...

427

Eccrine Sweat Contains IL-1?, IL-1? and IL-31 and Activates Epidermal Keratinocytes as a Danger Signal  

PubMed Central

Eccrine sweat is secreted onto the skin's surface and is not harmful to normal skin, but can exacerbate eczematous lesions in atopic dermatitis. Although eccrine sweat contains a number of minerals, proteins, and proteolytic enzymes, how it causes skin inflammation is not clear. We hypothesized that it stimulates keratinocytes directly, as a danger signal. Eccrine sweat was collected from the arms of healthy volunteers after exercise, and levels of proinflammatory cytokines in the sweat were quantified by ELISA. We detected the presence of IL-1?, IL-1?, and high levels of IL-31 in sweat samples. To investigate whether sweat activates keratinocytes, normal human keratinocytes were stimulated with concentrated sweat. Western blot analysis demonstrated the activation of NF-?B, ERK, and JNK signaling in sweat-stimulated keratinocytes. Real-time PCR using total RNA and ELISA analysis of supernatants showed the upregulation of IL-8 and IL-1? by sweat. Furthermore, pretreatment with IL-1R antagonist blocked sweat-stimulated cytokine production and signal activation, indicating that bioactive IL-1 is a major factor in the activation of keratinocytes by sweat. Moreover, IL-31 seems to be another sweat stimulator that activates keratinocytes to produce inflammatory cytokine, CCL2. Sweat is secreted onto the skin's surface and does not come into contact with keratinocytes in normal skin. However, in skin with a defective cutaneous barrier, such as atopic dermatitis-affected skin, sweat cytokines can directly act on epidermal keratinocytes, resulting in their activation. In conclusion, eccrine sweat contains proinflammatory cytokines, IL-1 and IL-31, and activates epidermal keratinocytes as a danger signal. PMID:23874436

Dai, Xiuju; Okazaki, Hidenori; Hanakawa, Yasushi; Murakami, Masamoto; Tohyama, Mikiko; Shirakata, Yuji; Sayama, Koji

2013-01-01

428

Species in Parks: Flora and Fauna Database  

NSDL National Science Digital Library

The Information Center of the Environment and the US National Park Service (NPS) have developed a "preliminary" data base of vascular plants and vertebrates located on National Park Service Lands. Although the database is not a complete list of species residing on NPS lands, it contains relatively complete lists for both small and large parks. Users can search for plants and animals by species or park name. Within each park, one can search a list of species by taxa (e.g., birds, mammals, fish, etc.) and then learn in what other parks that species is found. Links to the home pages for all NPS property (from American Samoa to Zion National Park) are featured. Both plant and animal databases are available for downloading for Windows or DOS users (.exe).

1997-01-01

429

Topological visual navigation in large environments IlPyung Park and John R. Kender  

E-print Network

, the map­maker and the navigator. Given a source and a goal, the map­maker derives a navigational path map generated by the map­maker, the nav­ igating robot looks for events that are characterized by spatial properties of the environment. The map­maker and navigator are implemented using two cameras

430

Svelato il codice genetico del lievito enologico  

Microsoft Academic Search

Primi al mondo, i ricercatori del 'The Australian Wine Research Institute' hanno completato il sequenziamento del genoma di un lievito enologico, descrivendo le 'ricette vitali' che danno forma all'amico dell'enologo. Questa ricerca apre la strada allo sviluppo di nuovi ceppi di lievito, in grado di offrire soluzioni innovative per il problema degli arresti di fermentazione, e di aumentare la gamma

Anthony R. Borneman; Angus H. Forgan; Paul J. Chambers; Isak S. Pretorius

431

Start up Italy: il talento delle idee  

E-print Network

Start up Italy: il talento delle idee Le start up come opportunità per i giovani di dare spazio persona fisica > Essere residente in Italia Contributo da parte di Bain & Company Italy: > Bain offrirà Istituzioni Finanziarie Giuria: > La giuria è composta da Partner e Manager di Bain & Company Italy Il

Robbiano, Lorenzo

432

IL-1 Blockade in Autoinflammatory Syndromes1  

PubMed Central

Monogenic autoinflammatory syndromes present with excessive systemic inflammation including fever, rashes, arthritis, and organ-specific inflammation and are caused by defects in single genes encoding proteins that regulate innate inflammatory pathways. Pathogenic variants in two interleukin-1 (IL-1)–regulating genes, NLRP3 and IL1RN, cause two severe and early-onset autoinflammatory syndromes, CAPS (cryopyrin associated periodic syndromes) and DIRA (deficiency of IL-1 receptor antagonist). The discovery of the mutations that cause CAPS and DIRA led to clinical and basic research that uncovered the key role of IL-1 in an extended spectrum of immune dysregulatory conditions. NLRP3 encodes cryopyrin, an intracellular “molecular sensor” that forms a multimolecular platform, the NLRP3 inflammasome, which links “danger recognition” to the activation of the proinflammatory cytokine IL-1?. The success and safety profile of drugs targeting IL-1 in the treatment of CAPS and DIRA have encouraged their wider use in other autoinflammatory syndromes including the classic hereditary periodic fever syndromes (familial Mediterranean fever, TNF receptor–associated periodic syndrome, and hyperimmunoglobulinemia D with periodic fever syndrome) and additional immune dysregulatory conditions that are not genetically well defined, including Still’s, Behcet’s, and Schnitzler diseases. The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1?-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease. PMID:24422572

Jesus, Adriana A.; Goldbach-Mansky, Raphaela

2014-01-01

433

The specific IL-1 inhibitor from the human M20 cell line is distinct from the IL-1 receptor antagonist.  

PubMed

Several inhibitors of IL-1 have been described. Four appear to be the same: one purified from urine of patients with monocytic leukemia, another from IgG-stimulated monocytes, a third from PMA-induced U937 cels, and a fourth from keratinocytes. Because these IL-1 inhibitors compete with bona fide IL-1 for occupancy of IL-1 receptors, they are now called the IL-1 receptor antagonist (IL-1ra) or IL-1 receptor antagonist protein (IRAP). We have described another IL-1-specific inhibitor produced by the human myelomonocytic leukemia cell line, M20. This inhibitor specifically blocks IL-1-induced effects both in vitro and in vivo. In the present study, we compared the M20 IL-1 inhibitor with IL-1ra using neutralization in an IL-1 bioassay and immunoblotting with an anti-IL-1ra antibody that recognizes natural IL-1ra. Neutralization experiments, immunoblotting, and western blotting obtained after transfer from SDS-PAGE revealed that anti-IL-1ra does not recognize the M20 IL-1 inhibitor. In addition, the isoelectric point and molecular weight of the M20 IL-1 inhibitor were different from those of the IL-1ra. From these data, we conclude that the M20 IL-1 inhibitor is antigenically unrelated to the IL-1ra but is a distinct and specific IL-1 inhibitor. PMID:1839505

Barak, V; Peritt, D; Flechner, I; Yanai, P; Halperin, T; Treves, A J; Dinarello, C A

1991-12-01

434

Computational methods of Gaussian Particle Swarm Optimization (GPSO) and Lagrange Multiplier on economic dispatch issues (case study on electrical system of Java-Bali IV area)  

NASA Astrophysics Data System (ADS)

The objective in this paper is about economic dispatch problem of electric power generation where scheduling the committed generating units outputs so as to meet the required load demand at minimum operating cost, while satisfying all units and system equality and inequality constraint. In the operating of electric power system, an economic planning problem is one of variables that its must be considered since economically planning will give more efficiency in operational cost. In this paper the economic dispatch problem which has non linear cost function solved by using swarm intelligent method is Gaussian Particle Swarm Optimization (GPSO) and Lagrange Multiplier. GPSO is a population-based stochastic algorithms which their moving inspired by swarm intelligent and probabilities theories. To analize its accuracy, the economic dispatch solution by GPSO method will be compared with Lagrange multiplier method. From the running test result the GPSO method give economically planning calculation which it better than Lagrange multiplier method and the GPSO method faster to getting error convergence. Therefore the GPSO method have better performance to getting global best solution than the Lagrange method.

Komsiyah, S.

2014-03-01

435

A discontinuous Galerkin method with plane waves and Lagrange multipliers for the solution of short wave exterior Helmholtz problems on unstructured meshes  

Microsoft Academic Search

Recently, a discontinuous Galerkin method with plane wave basis functions and Lagrange multiplier degrees of freedom was proposed for the efficient solution of the Helmholtz equation in the mid-frequency regime. This method was fully developed however only for regular meshes, and demonstrated only for interior Helmholtz problems. In this paper, we extend it to irregular meshes and exterior Helmholtz problems

Charbel Farhat; Paul Wiedemann-Goiran; Radek Tezaur

2004-01-01

436

Correlation between serum levels of IL-15 and IL-17 in patients with idiopathic inflammatory myopathies.  

PubMed

Objectives: To assess the serum levels of interleukin (IL)-15 and IL-17 in patients with idiopathic inflammatory myopathies (IIM) and correlate them with levels of IL-1 receptor antagonist (IL-1ra), IL-6, IL-10, interferon (IFN)-?, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1?, and MIP-1?. Possible correlations with disease activity parameters were also evaluated. Method: Sera from 14 patients with new-onset polymyositis (PM), 10 with dermatomyositis (DM), seven with anti-synthetase syndrome (ASS) and 19 healthy controls (HC) were analysed by multiplex immunoassay. Sera from 19 patients were analysed after a median follow-up of 5 months. All patients underwent physical examination, manual muscle testing (MMT) using the five-point MMT scales, the Health Assessment Questionnaire (HAQ), and serum creatine kinase (CK) measurement. All patients received glucocorticoids, and 13 were taking immunosuppressive therapy. Results: At baseline, serum levels of IL-15, IL-17, MCP-1, and MIP-1? were significantly higher in IIM patients than in HC. IL-17 serum levels were directly correlated (r = 0.39, p = 0.02) with disease duration while a significant inverse correlation was detected between IL-17 levels and MMT scores (r = -0.4, p = 0.02). The highest IL-15 levels were present in DM patients (p = 0.02 vs. PM). The most striking finding was the strong correlation between IL-15 and IL-17 levels (r = 0.60, p = 0.0001), and this correlation was even stronger in DM patients (r = 0.82, p = 0.006). Conclusions: The strong correlation between IL-15 and IL-17 in IIM patients, and especially in DM, suggests that there may be an interplay between the two cytokines in the pathogenesis of myositis. Further studies of larger patient cohorts and of muscle biopsies are needed to confirm these preliminary data. PMID:25379698

Notarnicola, A; Lapadula, G; Natuzzi, D; Lundberg, Ie; Iannone, F

2014-11-01

437

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL2, IL4, IL7, IL13, and IL15  

Microsoft Academic Search

To understand the molecular bases for cytokine redundancy and plelotropy, we have compared the Stat proteins activated in peripheral blood lymphocytes (PBLs) by cytokines with shared and distinct actions. Interleukin-2 (IL-2) rapidly activated Stat5 in fresh PBL, and Stat3 and StatS in preactivated PBL. IL-7 and IL-15 induced the same complexes as IL-2, a feature explained by the existence of

Jian-Xin Lin; Thi-Sau Migone; Monica Tseng; Michael Friedmann; James A. Weatherbee; Li Zhou; Akira Yamauchi; Eda T. Bloom; Judy Mietz; Susan John; Warren J. Leonard

1995-01-01

438

Analysis of complex elastic structures by a Rayleigh-Ritz component modes method using Lagrange multipliers. Ph.D. Thesis  

NASA Technical Reports Server (NTRS)

The free vibrations of elastic structures of arbitrary complexity were analyzed in terms of their component modes. The method was based upon the use of the normal unconstrained modes of the components in a Rayleigh-Ritz analysis. The continuity conditions were enforced by means of Lagrange Multipliers. Examples of the structures considered are: (1) beams with nonuniform properties; (2) airplane structures with high or low aspect ratio lifting surface components; (3) the oblique wing airplane; and (4) plate structures. The method was also applied to the analysis of modal damping of linear elastic structures. Convergence of the method versus the number of modes per component and/or the number of components is discussed and compared to more conventional approaches, ad-hoc methods, and experimental results.

Klein, L. R.

1974-01-01

439

Science Enabled by the Ares V: A Large Monolithic Telescope Placed at the Second Sun-Earth Lagrange Point  

NASA Technical Reports Server (NTRS)

The payload mass and volume capabilities of the planned Ares V launch vehicle provide the science community with unprecedented opportunities to place large science payloads into low earth orbit and beyond. One example, the outcome of a recent study conducted at the NASA Marshall Space Flight Center, is a large, monolithic telescope with a primary mirror diameter of 6.2 meters placed into a halo orbit about the second Sun-Earth Lagrange point, or L2, approximately 1.5 million kin beyond Earth's orbit. Operating in the visible and ultraviolet regions of the electromagnetic spectrum, such a large telescope would allow astronomers to detect bio-signatures and characterize the atmospheres of transiting exoplanets, provide high resolution imaging three or more times better than the Hubble Space Telescope and the James Webb Space Telescope, and observe the ultraviolet light from warm baryonic matter.

Hopkins, Randall C.; Stahl, H. Philip

2007-01-01

440

The Lagrange Street story: the prevention of aromatics air pollution during the last nine years in a European city  

NASA Astrophysics Data System (ADS)

Benzene, toluene and xylenes (BTX) air pollution is a very important topic for environmental health, due to the toxicity and/or mutagenetic or carcinogenetic properties of these aromatics and the commercialisation of the unleaded gasoline containing amount of BTX. We measured BTX in the air of Turin city, the capital of Piedmont region (north-western Italy), during 10 years, from 1989 to 1998. The sampling site selected was Lagrange Street (LS), an "urban canyon" placed in the centre of the city. The behaviour of BTX in LS was conditioned by some local and national legislative measures enforced during 1990s for the reduction of automotive traffic and BTX air pollution, respectively. Taking into account the existence of similar measures undertaken also in several cities in the developed countries, largely described but never discussed, the aim of this study was to verify in LS the preventive effects of these regulatory actions by means of a longitudinal survey extended over 10 years. Results obtained in Lagrange Street highlight seasonal trends, typical of this kind of pollutants, and an important reduction (from 42.6 to 15.9 ppbv) of aromatic hydrocarbons (sum of benzene, toluene and xylenes) in atmospheric air from 1990 to 1997. In particular, the annual level of benzene in air showed a mean from 9.2 ppbv in 1990 to 2.0 ppbv in 1997, almost half of the 3.1 ppbv imposed by law since 31 December 1998. In conclusion, the present findings induce a consistent optimism about the usefulness and the effectiveness of these types of regulatory actions enforced to reduce the human exposure to BTX, which could be extended also to other trafficated sites where the aromatics air pollution has to be reduced.

Bono, Roberto; Bugliosi, Elva H.; Schilirň, Tiziana; Gilli, Giorgio

441

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis  

PubMed Central

Aberrant cytokine expression has been proposed as an underlying cause of psoriasis, although it is unclear which cytokines play critical roles. Interleukin (IL)-23 is expressed in human psoriasis and may be a master regulator cytokine. Direct intradermal administration of IL-23 in mouse skin, but not IL-12, initiates a tumor necrosis factor–dependent, but IL-17A–independent, cascade of events resulting in erythema, mixed dermal infiltrate, and epidermal hyperplasia associated with parakeratosis. IL-23 induced IL-19 and IL-24 expression in mouse skin, and both genes were also elevated in human psoriasis. IL-23–dependent epidermal hyperplasia was observed in IL-19?/? and IL-24?/? mice, but was inhibited in IL-20R2?/? mice. These data implicate IL-23 in the pathogenesis of psoriasis and support IL-20R2 as a novel therapeutic target. PMID:17074928

Chan, Jason R.; Blumenschein, Wendy; Murphy, Erin; Diveu, Caroline; Wiekowski, Maria; Abbondanzo, Susan; Lucian, Linda; Geissler, Richard; Brodie, Scott; Kimball, Alexa B.; Gorman, Daniel M.; Smith, Kathleen; de Waal Malefyt, Rene; Kastelein, Robert A.; McClanahan, Terrill K.; Bowman, Edward P.

2006-01-01

442

Oregon State Parks and Recreation  

NSDL National Science Digital Library

What can you do in the great Oregon outdoors? From the world of Cannon Beach to the wild and rugged Snake River, the experiences are diverse, to say the least. The homepage features dramatic vistas, isolated lighthouses, and a whole range of wonderful images to entice visitors. In the Visit area, there is an interactive map of the state that will help plan any trip. Here visitors can select Activities and Facilities to look for specific amenities. Moving along, the Event Calendar area allows visitors to look for upcoming events at a specific park or by category. Policy folks will appreciate the About Us area, as it includes detailed information on the Oregon Parks and Recreation Department's budget, their annual report, information about upcoming initiatives, and construction projects.

443

National Association for Olmsted Parks  

NSDL National Science Digital Library

Established in 1980, the National Association for Olmsted Parks (NAOP) is a coalition of various design and preservation professionals concerned with the legacy of landscape work left by noted landscape designer Frederick Law Olmsted Sr. and his colleagues. On their website, visitors can learn about Olmsted's primary works via a master list of design projects by his firm and some profiles of some of his most prominent work, including Central Park and the landscape at the Biltmore Estate. Scholars will want to look through the "Research" area for resources that include a set of suggested links and an extensive bibliography. Visitors will also want to look at the "News and Publications" area for more details about the NAOP's work and their newsletter.

444

Buddingtonite in Menlo Park, California  

USGS Publications Warehouse

The mineral buddingtonite, named after A.F. Buddington, long-time professor of petrology at Princeton University, was first identified at the Sulfur Bank mine in Lake County, California (Erd and others, 1964). The ammonium feldspar was recognized in Menlo Park, California, in 1964 by the author, with Erd's help, shortly before publication of the original description of the new mineral. Subsequently, buddingtonite has been widely recognized in hydrothermal mineral deposits and has been used in remote-sensing applications by the mineral industry. Buddingtonite also has been identified in the Phosphoria Formation and in oil shales of the Green River Formation. This paper briefly describes the geologic setting and mineralogy of the occurrences of buddingtonite and other ammonium-bearing minerals in the vicinity of Menlo Park.

Pampeyan, Earl H.

2010-01-01

445

The Bronx Park Postcard Collection  

NSDL National Science Digital Library

Over the years since its origins in the late 1880s, the Bronx Park has been expanded several times. In 1891, the city of New York allotted 250 acres of the park to the New York Botanical Garden, and in 1897 assigned 250 more to the Bronx Zoo. This particular digital collection brings together postcards of the grounds held by the Wildlife Conservation Society Library and the Garden's LuEsther T. Mertz Library. The collection here includes over 450 postcards, which visitors can browse by subject headings, including Zoo animals, Paths and walkways, and Bronx River. The Zoo animals area is well worth a look, as it features a range of animals, including a Noah's Ark exhibit, camels, and Indian elephants. It's an amazing archive of documents related to one of the most famous zoos in the United States, and historians and others will find it quite marvelous.

446

National Park Service Web Cameras  

NSDL National Science Digital Library

The National Park Service (NPS) operates digital cameras at many parks in the lower 48 states, Alaska, and Hawaii to help educate the public on air quality issues. These cameras often show the effects of air pollution, especially visibility impairment. Because the cameras are typically located near air quality monitoring sites, their web pages display other information along with the photo, such as current levels of ozone, particulate matter, or sulfur dioxide, visual range, and weather conditions. The digital photos are usually updated every 15 minutes, while air quality data values are revised hourly. Charts of the last ten days of hourly weather, ozone, particulate matter, or sulfur dioxide data are also available. The cameras are accessible by clicking on an interactive map.

447

Hyde Park Herald Digital Collections  

NSDL National Science Digital Library

Hyde Park is a well-known urban neighborhood eight miles south of Chicago's Loop, and residents in and around the neighborhood have a long tradition of independent journalism. The Hyde Park Herald was started in 1882, and it documented the community's earliest history, including the years before the neighborhood was annexed to Chicago. Recently, a group of concerned citizens donated money to digitize the newspaper's back issues, and it was done to celebrate the leadership of Bruce Sagan, who has published the newspaper since 1953. Visitors can view the newspaper from 1882 to the present day, and despite a gap between the years 1889 and 1918, the coverage is quite good. Some good starting points include the WWII years and the late 1950s, which was when the first urban renewal project started in the neighborhood. Also, visitors may wish to perform a detailed search across the entire collection and then can also learn a bit more about the paper's history here.

448

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies.  

PubMed

The inflammasome is a cytoplasmic multiprotein complex that promotes proinflammatory cytokine maturation in response to host- and pathogen-derived signals. Missense mutations in cryopyrin (NLRP3) result in a hyperactive inflammasome that drives overproduction of the proinflammatory cytokines IL-1? and IL-18, leading to the cryopyrin-associated periodic syndromes (CAPS) disease spectrum. Mouse lines harboring CAPS-associated mutations in Nlrp3 have elevated levels of IL-1? and IL-18 and closely mimic human disease. To examine the role of inflammasome-driven IL-18 in murine CAPS, we bred Nlrp3 mutations onto an Il18r-null background. Deletion of Il18r resulted in partial phenotypic rescue that abolished skin and visceral disease in young mice and normalized serum cytokines to a greater extent than breeding to Il1r-null mice. Significant systemic inflammation developed in aging Nlrp3 mutant Il18r-null mice, indicating that IL-1 and IL-18 drive pathology at different stages of the disease process. Ongoing inflammation in double-cytokine knockout CAPS mice implicated a role for caspase-1-mediated pyroptosis and confirmed that CAPS is inflammasome dependent. Our results have important implications for patients with CAPS and residual disease, emphasizing the need to explore other NLRP3-mediated pathways and the potential for inflammasome-targeted therapy. PMID:24084736

Brydges, Susannah D; Broderick, Lori; McGeough, Matthew D; Pena, Carla A; Mueller, James L; Hoffman, Hal M

2013-11-01

449

Alan Turing and Bletchley Park  

Microsoft Academic Search

This month marks the 100th anniversary of Alan Turing's birth. His ground-breaking work in the 1940s continues to have an impact on computer science as we know it. The first featured Web extra at http:\\/\\/youtu.be\\/5nK_ft0Lf1s is a video interview with Paul Kellar, Kevin Murrell, and Joel Greenberg of the National Museum of Computing at Bletchley Park celebrating the 100th anniversary

Charles Severance

2012-01-01

450

Bridgeview Park facility solar retrofit  

SciTech Connect

The weatherization and insulation of a presently unheated frame park building and the installation of a Trombe wall on the south side of the structure for passive solar heating are planned. The major objectives of the project are to increase the exposure of local residents and visitors to passive solar technology and to demonstrate the applicability of passive solar technology to residential, commercial and recreational buildings. Some changes in the original plans are discussed. Five blueprints illustrate the planned improvements. (LEW)

Not Available

1981-01-01

451

Yellowstone National Park Online Tours  

NSDL National Science Digital Library

This Yellowstone National Park website provides an array of online tours, videos, and other information. Nature and history tours are among those featured on the site. The nature tours cover the Old Faithful area, the Norris Geyser Basin, the Fountain Paint Pots, the Mammoth Hot Springs, and the Grand Canyon of the Yellowstone. Each of these tours highlights prominent natural features with photos and descriptions.

Yellowstone National Park

452

VARIAZIONI DATE DI INIZIO LEZIONI -Il corso di RELATIVITA' GENERALE tenuto dalla prof.ssa V. Ferrari inizier il 2  

E-print Network

ed. Marconi - Il corso di LABORATORIO DI FISICA (prof. F. Bordi) inizia Mercoledì 1 ottobre - Il RELATIVISTICA (prof. M. Grilli) inizierà mercoledi 8 Ottobre. - Il corso di LABORATORIO DI SEGNALI E SISTEMI Ottobre #12;- Il primo incontro con gli studenti per il corso di INTRODUZIONE ALLA GRAVITA' QUANTISTICA

Roma "La Sapienza", UniversitĂ  di

453

Dual Role of IL-22 in Allergic Airway Inflammation and its Cross-talk with IL-17A  

E-print Network

allergic asthma and its cross- talk with IL-17A. Methods: IL-22 expression was assessed in patient samples, the effects of recombinant IL-22 and IL-17A neutralizing antibodies were investigated. Measurements and Main Results: Increased pulmonary IL-22 expres- sion is found in the serum of patients with asthma and mice

454

A Pivotal Role for CD40-Mediated IL-6 Production by Dendritic Cells during IL-17 Induction In Vivo1  

E-print Network

A Pivotal Role for CD40-Mediated IL-6 Production by Dendritic Cells during IL-17 Induction In Vivo1- and IL-6 in the Th17 induction process (8­10), and the current understanding is that TGF- and IL-6 population (9) in a process rein- forced by IL-21 (11­13). The involvement of TGF- in both Th17

MacDonald, Andrew

455

Coordinating OBS Parks in Europe  

NASA Astrophysics Data System (ADS)

Within Europe there are more than 380 Ocean Bottom Seismometers (OBS) distributed across 10 instrument parks in 6 countries. At least 120 of these OBS are wideband or broadband, over 260 can be deployed for at least 6 months at a time and 140 for at least one year. New parks are planned in two other European countries, which should add over 70 OBSs to this "fleet". However, these parks are under the control of individual countries or universities and hence to date this has made it difficult to organize large-scale experiments, especially for seismologists without marine experience. There has recently been an initiative to coordinate the use of these distributed instruments and their data products, to encourage large-scale experiments, possibly with onshore and offshore components, by seismologists who have not necessarily used OBSs before. The ongoing or planned developments include: Helping scientists with marine-specific formalities such as ship requests; clearer explanations of the noise floors of OBS instrumentation; improved clarity of instrument pricing and availability; standardized data output formats and data validation; and archiving in established seismological data centers. These efforts should allow improved experiment design in scientifically interesting regions with an offshore component and an easier, clearer way to organize large-scale, multi-country experiments. We will present details of this initiative to help organize large-scale experiments, the particularities of OBS sensors and marine deployments, the available instrumentation and new developments.

Crawford, W.; Brisbourne, A.; D'Anna, G.; Flüh, E. R.; Galve, A.; Graindorge, D.; Harmon, N.; Henstock, T.; Klingelhöfer, F.; Mangano, G.; Matias, L.; Peirce, C.; Sallares, V.; Schmidt-Aursch, M.; Tilmann, F.; Voss, P.

2012-04-01

456

IL-4/IL-13-Dependent Alternative Activation of Macrophages but Not Microglial Cells Is Associated with Uncontrolled Cerebral Cryptococcosis  

PubMed Central

Both interleukin (IL)-4- and IL-13-dependent Th2-mediated immune mechanisms exacerbate murine Cryptococcus neoformans-induced bronchopulmonary disease. To study the roles of IL-4 and IL-13 in cerebral cryptococcosis, IL-4 receptor ?-deficient (IL-4R??/?), IL-4-deficient (IL-4?/?), IL-13-deficient (IL-13?/?), IL-13 transgenic (IL-13T/+), and wild-type mice were infected intranasally. IL-13T/+ mice displayed a higher fungal brain burden than wild-type mice, whereas the brain burdens of IL-4R??/?, IL-4?/?, and IL-13?/? mice were significantly lower as compared with wild-type mice. On infection, 68% of wild-type mice and 88% of IL-13-overexpressing IL-13T/+ mice developed significant cerebral lesions. In contrast, only a few IL-4R??/?, IL-4?/?, and IL-13?/? mice had small lesions in their brains. Furthermore, IL-13T/+ mice harbored large pseudocystic lesions in the central nervous system parenchyma, bordered by voluminous foamy alternatively activated macrophages (aaMphs) that contained intracellular cryptococci, without significant microglial activation. In wild-type mice, aaMphs tightly bordered pseudocystic lesions as well, and these mice, in addition, showed microglial cell activation. Interestingly, in resistant IL-4?/?, IL-13?/?, and IL-4R??/? mice, no aaMphs were discernible. Microglial cells of all mouse genotypes neither internalized cryptococci nor expressed markers of alternative activation, although they displayed similar IL-4R? expression levels as macrophages. These data provide the first evidence of the development of aaMphs in a central nervous system infectious disease model, pointing to distinct roles of macrophages versus microglial cells in the central nervous system immune response against C. neoformans. PMID:19147811

Stenzel, Werner; Müller, Uwe; Köhler, Gabriele; Heppner, Frank L.; Blessing, Manfred; McKenzie, Andrew N.J.; Brombacher, Frank; Alber, Gottfried

2009-01-01

457

IL-17/miR-192/IL-17Rs Regulatory Feedback Loop Facilitates Multiple Myeloma Progression  

PubMed Central

Multiple myeloma (MM) is a clonal plasma cell disorder which constitutes the second most common hematological malignancy, and remains an incurable tumor with poor survival. Recently, interleukin-17 (IL-17), produced locally in the tumor microenvironment, has been reported to play a crucial role in tumor immunity. In this study, we determined that exposure of MM cells to IL-17 had various promotive influences on different aspects of tumor progression. IL-17 significantly induced cell proliferation, inhibited cellular apoptosis, repressed cell adhesion to fibronectin and collagen I, and facilitated cell migration. Exposure to IL-17 also resulted in epithelial-mesenchymal transition (EMT), as evidenced by repression of the epithelial marker E-cadherin, and induction of the mesenchymal marker Vimentin, and EMT transcription factors Snail and Slug. Further experiments showed that IL-17 activated the oncogenic p65 transcription factor, which directly repressed the miR-192 gene via binding to the miR-192 promoter. Loss of miR-192 in MM cells can mimic the effects of IL-17, and was required for the above oncogenic effects of IL-17 on MM. Furthermore, we found that miR-192, and its homologous miR-215 directly targeted the 3?-untranslated regions of IL-17Rs, including IL-17RA and RE mRNA. By examining bone marrow specimens derived from MM patients, a negative correlation between miR-192 expression and IL-17 or IL-17RA expression was observed. Also, IL-17 was negatively correlated with E-cadherin and positively with Vimentin. Taken together, our study provides evidence that the IL-17/miR-192/IL-17Rs regulatory feedback loop is manifest in MM and might represent a promising and efficient prognostic marker and therapeutic target for MM. PMID:25489847

Sun, Yuanyuan; Pan, Jing; Mao, Shudan; Jin, Jieping

2014-01-01

458

COMUNICATO STAMPA Convegno internazionale Tra memoria e utopia: il samizdat  

E-print Network

COMUNICATO STAMPA Convegno internazionale Tra memoria e utopia: il samizdat come simbolo della'Universitŕ degli Studi di Padova (Sala Nievo, Palazzo del Bo) il convegno internazionale Tra memoria e utopia: il

Cesare, Bernardo

459

Decreto n. 6259 IL RETTORE dipartimento risorse umane e organizzazione  

E-print Network

Direttore del Dipartimento di Biomedicina dell'Età Evolutiva per il triennio accademico 2007/2010; VISTO il del Dipartimento di Biomedicina dell'Età Evolutiva per il triennio accademico 2010/2013. Bari, lì 20

Malerba, Donato

460

Interrelationship between IL-3 and mast cells.  

PubMed

It is well established that mast cells, which are found in the tissues in the proximity of small blood vessels and post-capillary venules, play a key role in the early phase of IgE-mediated allergic reactions. A greatly expanded understanding of the biology of IL-3 has emerged since the early 1980s. IL-3 is a specific factor that stimulates the growth of hematopoietic stem and progenitor cells of a variety of lineages and can promote the proliferation of certain classes of lymphocytes distinct from those that are dependent on IL-2. IL-3 has been identified among the most important cytokines for regulation of mast cell growth and differentiation, migration and effector function activities of many hematopoietic cells. IL-3 termed multi colony-stimulating-factor (multi-CSF) or mast cell growth factor (MCGF) is a haematopoietic growth factor which stimulates the formation of colonies for erythroid, megakaryocytic, granulocytic and monocytic lineages. It is predominantly produced by activated T cells, natural killer (NK) cells and mast cells and supports the growth-promoting effects of SCF on mast cell precursors. IL-3 causes severe hypersensivity reactions and plays a pivotal role in exacerbating the inflammatory response in vivo. Here we report the interrelationship between IL-3 and mast cells. PMID:24750787

Kritas, S K; Saggini, A; Cerulli, G; Caraffa, A; Antinolfi, P; Pantalone, A; Saggini, R; Frydas, S; Rosati, M; Tei, M; Speziali, A; Pandolfi, F; Conti, P

2014-01-01

461

Extracorporeal Photopheresis Promotes IL-1? Production.  

PubMed

Extracorporeal photopheresis (ECP) is a widely used clinical cell-based therapy exhibiting efficacy in heterogenous immune-mediated diseases such as cutaneous T cell lymphoma, graft-versus-host disease, and organ allograft rejection. Despite its documented efficacy in cancer immunotherapy, little is known regarding the induction of immunostimulatory mediators by ECP. In this article, we show that ECP promotes marked release of the prototypic immunostimulatory cytokine IL-1?. ECP primes IL-1? production and activates IL-1? maturation and release in the context of caspase-1 activation in monocytes and myeloid dendritic cells. Of interest, IL-1? maturation by ECP was fully intact in murine cells deficient in caspase-1, suggesting the predominance of an inflammasome-independent pathway for ECP-dependent IL-1? maturation. Clinically, patient analysis revealed significantly increased IL-1? production in stimulated leukapheresis concentrates and peripheral blood samples after ECP. Collectively, these results provide evidence for promotion of IL-1? production by ECP and offer new insight into the immunostimulatory capacity of ECP. PMID:25681340

Yakut, Erhan; Jakobs, Christopher; Peric, Adriana; Michel, Gabriela; Baal, Nelli; Bein, Gregor; Brüne, Bernhard; Hornung, Veit; Hackstein, Holger

2015-03-15

462

Geology Fieldnotes: Theodore Roosevelt National Park, North Dakota  

NSDL National Science Digital Library

This Theodore Roosevelt National Park site contains park geology information, park maps, photographs, related links, visitor information, and teacher features (resources for teaching geology with National Park examples). The park geology section discusses the Park's geologic history and the region's role in shaping Theodore Roosevelt's conservation efforts while he was President. The section also contains a link to information on the geology of Theodore Roosevelt National Park. The park maps section contains an area map as well as two maps detailing the North and South Units of the Park.

463

Lipopolysaccharide stimulates platelets through an IL-1? autocrine loop  

PubMed Central

Lipopolysaccharide (LPS) activates platelets through TLR4, aiding productive sepsis, with stimulated splicing and translation of stored heteronuclear pro-Interleukin-1? (IL-1?)RNA. Although the IL1R1 receptor for IL1 shares downstream components with the TLR4 receptor, platelets are not known to express IL1R1, nor are they known to respond to this cytokine. We show by flow cytometry and western blotting that platelets express IL1R1, and that IL-1? and IL-1? stimulate heteronuclear I-1? splicing and translation of the newly made mRNA in platelets. Platelets also respond to the IL-1? they make, which is exclusively associated with shed microparticles. Specific blockade of IL1R1 with IL1 receptor antagonist (IL1Ra) suppressed platelet stimulation by IL1, so IL-1? stimulates its own synthesis in an autocrine signaling loop. Strikingly, IL1Ra inhibition, pharmacologic or genetic suppression of pro-IL-1? processing to active cytokine by caspase-1, or blockade of de novo protein synthesis also blocked LPS-induced IL-1? mRNA production. Robust stimulation of platelets by LPS therefore also required IL-1? amplification. Activated platelets made IL-1? in vivo as IL-1? rapidly accumulated in occluded murine carotid arteries by post-transcriptional RNA splicing unique to platelets. We conclude IL-1? is a platelet agonist, that IL-1? acts through an autocrine stimulatory loop, that an IL-1? autocrine loop is required to amplify platelet activation by LPS, and that platelets immobilized in occlusive thrombi are activated over time to produce IL-1?. IL1 is a new platelet agonist that promotes its own synthesis, connecting thrombosis with immunity. PMID:24081990

Li, Wei; Silverstein, Roy L.; McIntyre, Thomas M.

2013-01-01

464

IL-6 trans-signaling enhances CCL20 production from IL-1?-stimulated human periodontal ligament cells.  

PubMed

CC chemokine ligand 20 (CCL20) plays a central role in the recruitment of CCR6-expressing cells, including Th17 cells which are related to bone resorption in periodontal lesions and thus in the development of periodontal disease. IL-6 is an important cytokine that is associated with the pathogenesis of periodontitis. However, the effect of IL-6 on CCL20 production is uncertain. The aim of this study was to examine whether IL-6 could modify CCL20 expression in human periodontal ligament cells (HPDLCs). HPDLCs expressed gp130 but did not express IL-6R on the surface of HPDLCs. So, IL-6 trans-signaling is important to recognize IL-6 by HPDLCs. IL-6/sIL-6R stimulation enhanced CCL20 production in IL-1?-stimulated HPDLCs. IL-6 produced from IL-1?-stimulated HPDLCs with sIL-6R could increase CCL20 production in HPDLCs with sIL-6R. Signal transducer and activator of transcription (STAT)3 activation was related to CCL20 production in IL-1? and IL-6/sIL-6R-stimulated HPDLCs. Our data suggests that HPDLCs, in response to IL-6, sIL-6R, and IL-1?, may shift chemokine production to that favoring CCR6-expressing cells recruitment in periodontal lesions. PMID:24081898

Hosokawa, Yoshitaka; Shindo, Satoru; Hosokawa, Ikuko; Ozaki, Kazumi; Matsuo, Takashi

2014-04-01

465

National Park Service, Nature & Science: Teacher Resources  

NSDL National Science Digital Library

The National Park Service has developed this exemplary set of educational resources which draws on their greatest assets, namely national parks from Maine to Utah. The materials are specifically designed for teaching geology, but it's easy to see how these items could be incorporated into general science classes. The main area on their homepage features over a dozen teacher guides and park programs that feature detailed geology lessons that draw on the landscapes of Yosemite National Park and the dynamic volcanoes of Hawaii. On the right side of the page, visitors can scan through the "Highlights" area to learn more about online park images, park maps, and even peruse a calendar of upcoming educator workshops. The site is rounded out by the "Geology Books and Media" area, which features information about technical reports, textbooks, and geology-themed children's books.

466

Il17A autoantibody induced by recombinant protein Ag85A-Il17A.  

PubMed

IL17A is a widely studied cytokine which plays an important role in autoimmune diseases as well as asthma. In this study, murine IL17a gene fragment was inserted into pET28a-Ag85A and it was expressed as a fusion protein named Ag85A-IL17A. Recombinant protein Ag85A-IL17A was expressed as an open reading frame of 1,287 bp, encoding a polypeptide of 429 amino acid residues with a predicted molecular mass of 50 kDa. It was expressed in Escherichia coli. BL21 and purified by metal affinity chromatography using a nickel-nitrilotriacetic acid column. Bioinformatics revealed that Ag85A-IL17A contained B cell epitopes of IL17A. Purified proteins Ag85A-IL17A and Ag85A were injected with adjuvants into mice then antibody responses in sera were measured by enzyme-linked immunosorbent assay and western blot assay. Experiments showed that purified protein Ag85-IL17A could bind to a standard IL17A antibody and could induce IL17A autoantibody in mice. PMID:23239413

Jin, Rong; Guo, Sheng; Wu, Liangxia; Fan, Xiaoyong; Ma, Hui; Lowrie, Douglas B; Zhang, Jianhua

2013-01-01

467

Photodynamic therapy affects the expression of IL-6 and IL-10 in vivo  

NASA Astrophysics Data System (ADS)

Photodynamic therapy (PDT), which can effectively destroy malignant tissue, also induces a complex immune response which potentiates anti-tumor immunity, but also inhibits skin contact hypersensitivity (CHS) and prolongs skin graft survival. The underlying mechanisms responsible for these effects are poorly understood, but are likely to involve meditation by cytokines. We demonstrate in a BALB/c mouse model that PDT delivered to normal and tumor tissue in vivo causes marked changes in the expression of cytokines interleukin (IL)-6 and IL-10. IL-6 mRNA and protein are rapidly and strongly enhanced in the PDT treated EMT6 tumor. Previous studies have shown that intratumoral injection of IL- 6 or transduction of the IL-6 gene into tumor cells can enhance tumor immunogenicity and inhibit tumor growth in experimental murine tumor systems. Thus, PDT may enhance local anti-tumor immunity by up-regulating IL-6. PDT also results in an increase in IL-10 mRNA and protein in the skin. The same PDT regime which enhances IL-10 production in the skin has been shown to strongly inhibit the CHS response. The kinetics of IL-10 expression coincide with the known kinetics of PDT induced CHS suppression and we propose that the enhanced IL-10 expression plays a role in the observed suppression of cell mediated responses seen following PDT.

Gollnick, Sandra O.; Musser, David A.; Henderson, Barbara W.

1998-05-01

468

Intrathymic IL-7: The where, when, and why of IL-7 signaling during T cell development  

PubMed Central

The thymus is the birthplace of all T lineage cells. But the thymus is also a cradle as it provides the environment for further maturation and differentiation of immature thymocytes. While many factors contribute to make the thymus a unique place for T cell development, here we review the essential role of intrathymic interleukin-7 (IL-7). In the absence of IL-7 signaling, survival, proliferation and differentiation of immature thymocytes are all severely impaired. Consequently, IL-7 is critical to nurture and guide T precursor cells through the diverse steps of thymic maturation. Interestingly, even as IL-7 signaling is such a critical factor, IL-7 signaling must be also actively suppressed during specific stages of T cell differentiation. These contradictory observations are puzzling but can be satisfactorily explained when understanding the developmental context of IL-7 signaling. In this regard, here we will discuss the spatiotemporal expression of intrathymic IL-7 and address the stage-specific effects of IL-7 signaling in developing thymocytes. Specifically, we will review other facets of intrathymic IL-7 beyond its role as a pro-survival factor and so clarify and reaffirm the unique role of IL-7 as a prime factor in T cell development and differentiation. PMID:22421571

Hong, Changwan; Luckey, Megan; Park, Jung-Hyun

2012-01-01

469

The use of molecular tools in Parks Canada Agency  

E-print Network

restoration Protected areas management #12;Parks Canada and conservation · Parks Canada is a world leader Parks Canada is the world's first national park service. #12;Outline · Taxonomic identification Taxonomic Identification #12;Taxonomic Identification Nahanni National Park Reserve Issues: #12;Taxonomic

Blouin-Demers, Gabriel

470

Yosemite National Park: the continuous evolution of humanblack bear conflict  

E-print Network

Yosemite National Park: the continuous evolution of human­black bear conflict management Joseph s, particularly in Yosemite National Park. Yosemite National Park encompasses >3,077 km2 and attracts nearly 3 as Yosemite Valley, and approximately 77% of the park's human­bear conflicts occur in this area (National Park

471

"Humanities in the Parks" Internships University of Colorado  

E-print Network

of parks to people. National parks and cities are no longer seen as distant and disconnected from one opportunity for the National Park Service. People have always visited the national parks as a break from) in National Park System areas to serve as interns to help interpret the natural and cultural resources

Colorado at Boulder, University of

472

Geology Fieldnotes: Death Valley National Park, California/Nevada  

NSDL National Science Digital Library

This Death Valley National Park site contains park geology information, park maps, photographs, visitor information, and teacher features (resources for teaching geology using National Park examples). The Park Geology section contains an exaggerated cross-section showing the vertical rise within Death Valley. A link is provided to Death Valley's expanded geology page.

473

Smart parking reservation system using short message services (SMS)  

Microsoft Academic Search

This paper proposes a smart parking system to solve the problem of unnecessary time consumption in finding parking spot in commercial car park areas. A parking reservation system is developed in such a way that users book their parking spots through short message services (SMS). The SMS sent will be processed by a wireless communication instrumentation device called micro-RTU (Remote

N. H. H. M. Hanif; M. H. Badiozaman; H. Daud

2010-01-01

474

Wireless Mobile-Based Shopping Mall Car Parking System (WMCPS)  

Microsoft Academic Search

The existing car parking system in Malaysia usually required the car drivers to search an empty parking space in the car park without providing detail direction toward the available parking space. As the result, drivers may waste a lot of time and unnecessary energy while they turn around in the car park without direction and may cause car traffic congestion

Soh Chun Khang; Teoh Jie Hong; Tan Saw Chin; Shengqiong Wang

2010-01-01

475

Real time car parking system using image processing  

Microsoft Academic Search

Car parking lots are an important object class in many traffic and civilian applications. With the problems of increasing urban traffic congestion and the ever increasing shortage of space, these car parking lots are needed to be well equipped with automatic parking Information and Guidance systems. Goals of intelligent parking lot management include counting the number of parked cars, and

Sayanti Banerjee; Pallavi Choudekar; M. K. Muju

2011-01-01

476

Water resources management plan: Great Basin National Park  

Microsoft Academic Search

The enabling legislation creating Great Basin National Park calls for the National Park Service (NPS) to protect, manage, and administer the park in such manner as to conserve and protect the scenery as well as the natural, geologic, historic, and archaeological resources of the park. NPS policies require that each unit of the National Park System develop and implement a

R. W. Jacobs; M. Flora

1994-01-01

477

Status of biotic inventories in US national parks  

Microsoft Academic Search

It is the policy and obligation of the National Park Service to conduct baseline inventories of natural resources preserved in its 32 million hectare National Park System. We evaluated the status of natural resources information in 252 national parks and monuments: those park units that contain significant natural resources. Results show that few parks contain relatively complete systematic inventories for

Gary S. Waggoner

1995-01-01

478

2. SOUTH SIDE, FROM PARK ACROSS PARKING LOT/F STREET, LOOKING ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. SOUTH SIDE, FROM PARK ACROSS PARKING LOT/F STREET, LOOKING NORTH. - Oakland Naval Supply Center, Administration Building-Dental Annex-Dispensary, Between E & F Streets, East of Third Street, Oakland, Alameda County, CA

479

Serum sIL2r, IL6, IL10 and TNF-? level in familial Mediterranean fever patients  

Microsoft Academic Search

In this study we investigated cytokine levels in patients with familial Mediterranean fever (FMF). Twenty patients and 20\\u000a healthy controls were included. Ten patients had acute attacks of FMF, whereas the other 10 were in the silent period. Patients\\u000a with the acute exacerbation of FMF had higher soluble interleukin-2 receptor (sIL-2r), interleukin-6 (IL-6), tumour necrosis\\u000a factor-?, erythrocyte sedimentation rate (ESR),

Y. Baykal; K. Saglam; M. I. Yilmaz; A. Taslipinar; S. B. Akinci; A. Inal

2003-01-01

480

The expressions of mRNAs for interleukin-6 (IL6) and the IL6 receptor (IL6R) in the rat hypothalamus and midbrain during restraint stress  

Microsoft Academic Search

Over the past few years, it has been reported that physical and psychological stress elevate plasma interleukin-6 (IL-6), and that neural cells can produce IL-6 and have receptors for IL-6 (IL-6R). However, it is unknown whether IL-6 plays a role in regulating the functions of neural cells in response to stress. We demonstrated recently, using the reverse transcriptase-polymerase chain reaction

Koji Shizuya; Teruhisa Komori; Ryoichi Fujiwara; Satoru Miyahara; Masaki Ohmori; Junichi Nomura

1998-01-01

481

Evaluation of Noise Pollution in Urban Parks  

Microsoft Academic Search

The present study provides an evaluation of noise pollution in six Urban Parks located in the city of Curitiba, Brazil. Equivalent\\u000a noise levels (L\\u000a eq) were measured in 303 points (each point measured during 3 min) spread throughout the Parks. Measured values were confronted\\u000a with local legislation (Law 10625) allowed limits, and the Parks were thus classified as “acoustically polluted

Paulo Henrique Trombetta Zannin; Andressa Maria Coelho Ferreira; Bani Szeremetta

2006-01-01

482

Geology Fieldnotes: Arches National Park, Utah  

NSDL National Science Digital Library

This park is located on the Colorado Plateau near Moab, Utah, and contains many arches and sculpted sedimentary rocks. The visible rock formations in the park are the Entrada and Navajo sandstones. Covered topics include the formation of arches in stages, different types of arches, as well as sizes and names (Delicate Arch being the most famous). The site also provides visitor information, photos, maps, additional links, and a teacher feature (tools for teaching geology with National Park examples).

Annabelle Foos

483

Geology Fieldnotes: Mesa Verde National Park, Colorado  

NSDL National Science Digital Library

This National Park Service (NPS) site provides information about Mesa Verde National Park in southwestern Colorado, including geology, visitor information, illustrations, and additional links for more details. This park was home to the Anasazi people who were cliff dwellers in this area. Today you can see artifacts, native dwellings made of sandstone bricks, and learn about the Anasazi way of life, dating back to around 550 AD.

484

Off?Street Parking Policy without Parking Requirements: A Need for Market Fostering and Regulation  

Microsoft Academic Search

This paper addresses and extends upon the recent upsurge of interest in market?oriented reform of parking policy, which has been reinvigorated by the work of Donald Shoup. His market?oriented approach to parking policy is shown to be the more ambitious of two distinct challenges to the conventional supply?focused approach. The other is ‘parking management’. However, off?street parking markets and their

Paul A. Barter

2010-01-01

485

Neighborhood Poverty, Park Use, and Park-Based Physical Activity in a Southern California City  

PubMed Central

A rich literature indicates that individuals of lower socio-economic status engage in less leisure time physical activity than individuals of higher socio-economic status. However, the source of the difference is believed to be, in part, due to differential access to resources that support physical activity. However, it has not been shown as to whether equal access to parks can mitigate differences in leisure time physical activity. Using systematic direct observation, we quantified physical activity in neighborhood parks in a large Southern California city located in areas with high, medium, and a low percentage of households in poverty. We documented how neighborhood parks are managed and programmed and also interviewed both a sample of park users and a random sample of households within a mile radius of the parks. We found that parks are used less in high-poverty areas compared to medium- and low-poverty area parks, even after accounting for differences in size, staffing, and programming. The strongest correlates of park use were the number of part time staff, the number of supervised and organized programs, and knowing the park staff. Perceptions of safety were not relevant to park use among those interviewed in the park, however it had a small relationship with reported frequency of park use among local residents. Among park users, time spent watching electronic media was negatively correlated with the frequency of visiting the park. Future research should test whether increasing park staffing and programming will lead to increased park use in high-poverty neighborhoods. PMID:23010338

Cohen, Deborah; Han, Bing; Derose, Kathryn; Williamson, Stephanie; Marsh, Terry; Rudick, Jodi; McKenzie, Thomas L.

2013-01-01

486

Eco-industrial parks: stimulating sustainable development in mixed industrial parks  

Microsoft Academic Search

In several industrialised countries, there have occurred initiatives to establish eco-industrial parks. Originally, these were mainly based upon the exchange of resources between heavy industries in industrial complexes. These initiatives are generally referred to with the concepts of industrial symbiosis and eco-industrial parks. Since then, the concept of eco-industrial parks has been extended to another relevant type of industrial park,

A. J. D Lambert; F. A Boons

2002-01-01

487

WIND DATA REPORT Deer Island Parking Lot  

E-print Network

WIND DATA REPORT Deer Island Parking Lot May 1, 2003 ­ July 15, 2003 Prepared for Massachusetts...................................................................................................................... 7 Wind Speed Time Series............................................................................................................. 7 Wind Speed Distributions

Massachusetts at Amherst, University of

488

Effectiveness of parks in protecting tropical biodiversity.  

PubMed

We assessed the impacts of anthropogenic threats on 93 protected areas in 22 tropical countries to test the hypothesis that parks are an effective means to protect tropical biodiversity. We found that the majority of parks are successful at stopping land clearing, and to a lesser degree effective at mitigating logging, hunting, fire, and grazing. Park effectiveness correlates with basic management activities such as enforcement, boundary demarcation, and direct compensation to local communities, suggesting that even modest increases in funding would directly increase the ability of parks to protect tropical biodiversity. PMID:11141563

Bruner, A G; Gullison, R E; Rice, R E; da Fonseca, G A

2001-01-01

489

75 FR 20885 - National Park Week, 2010  

Federal Register 2010, 2011, 2012, 2013, 2014

...Proclamation 8498--National Park Week, 2010 Proclamation 8499--National Crime Victims' Rights Week, 2010 Proclamation 8500--National Volunteer Week, 2010 Proclamation 8501--National Day of Service and...

2010-04-21

490

Tour of Park Geology: Sand Dunes  

NSDL National Science Digital Library

This Park Geology site provides links to tours of individual National Parks, Monuments, and Recreation Areas with sand dunes. Where appropriate for each park, links are provided to maps, photographs, geologic research, related links, visitor information, and teacher features (resources for teaching geology with National Park examples). The list includes places such as Death Valley and Mojave National Preserve, along with less well-known areas such as the Pictured Rocks National Lakeshore in Michigan and the Wright Brothers National Memorial in North Carolina.

491

Parking Functions And Generalized Catalan Numbers  

E-print Network

, and showed that this generalized the relationship between parking functions and non-crossing partitions given earlier by Stanley[2]. Loehr, Haglund, and Haiman have explored the connections between parking functions and q,t-Catalan structures, as well as a.... (N.A. Loehr[19]) Corollary B.5. LT n+1 ? = LD n Proof. This is a combination of B.4 and B.2. Let IP n be the set of non-decreasing parking functions, i.e.,those parking func- tions (a 1 a 2 ...a n )wherea i ? a i+1 for all 1 ? i ? n ? 1. Let D n...

Schumacher, Paul R.

2010-01-14

492

IL13, IL4R?, and Stat6 Are Required for the Expulsion of the Gastrointestinal Nematode Parasite Nippostrongylus brasiliensis  

Microsoft Academic Search

Although IL-4 induces expulsion of the gastrointestinal nematode parasite, Nippostrongylus brasiliensis, from immunodeficient mice, this parasite is expelled normally by IL-4-deficient mice. This apparent paradox is explained by observations that IL-4 receptor ? chain (IL-4R?)-deficient mice and Stat6-deficient mice fail to expel N. brasiliensis, and a specific antagonist for IL-13, another activator of Stat6 through IL-4R?, prevents worm expulsion. Thus,

Joseph F Urban Jr.; Nancy Noben-Trauth; Debra D Donaldson; Kathleen B Madden; Suzanne C Morris; Mary Collins; Fred D Finkelman

1998-01-01

493

NATIONAL ENVIRONMENTAL RESEARCH PARKS A National Environmental Research Park is an outdoor laboratory where research may be  

E-print Network

CHARTER NATIONAL ENVIRONMENTAL RESEARCH PARKS A National Environmental Research Park is an outdoor for a quality environment into environmental goals, and the National Environmental Research Parks network DIRECTIVES FOR THE NATIONAL ENVIRONMENTAL RESEARCH PARKS PROGRAM The network of research parks was formally

Georgia, University of

494

76 FR 39048 - Special Regulations; Areas of the National Park System, Yellowstone National Park  

Federal Register 2010, 2011, 2012, 2013, 2014

...its use in the park would be prohibited...emissions of HC and CO greater than the proposed...allowed to enter the park. It would be...operated on the Cave Falls road, which extends...Emission Limit no greater than 120 g/kW-hr...operated in the park for a period not...operated on the Cave Falls Road in...

2011-07-05

495

78 FR 63069 - Special Regulations; Areas of the National Park System; Yellowstone National Park; Winter Use  

Federal Register 2010, 2011, 2012, 2013, 2014

...its use in the park will be prohibited...of HC and CO to greater than the emission...not enter the park. It is the responsibility...operating on the Cave Falls Road, which extends...apply to the Cave Falls Road and use by...affiliated with the park, the final rule...1051 to a FEL no greater than a total...

2013-10-23

496

78 FR 22470 - Special Regulations; Areas of the National Park System; Yellowstone National Park; Winter Use  

Federal Register 2010, 2011, 2012, 2013, 2014

...its use in the park would be prohibited...of HC and CO to greater than the proposed...allowed to enter the park. It would be...operating on the Cave Falls Road, which extends...apply to the Cave Falls Road, the proposed...operated in the park. Sec. 7.13...1051 to a FEL no greater than a total...

2013-04-16

497

Parks as Resources for Knowledge in Science (PARKS) National Program Evaluation Final Report.  

ERIC Educational Resources Information Center

This document evaluates the Parks as Resources for Knowledge in Science (PARKS) project which supports environmental education in 36 National Parks across the United States and provides curriculum-based learning opportunities that integrate National Science Education Standards for teachers and students. Contents include: (1) "Executive…

Wiltz, L. Kate

498

Water Resources Management Plan: Arches National Park & Canyonlands National Park, Utah  

Microsoft Academic Search

The National Park Service recognizes the importance of preserving, conserving, and protecting water resources within its boundaries. Water resources, whether as large as the Colorado River or as small as a seep in Ernie's Country of Canyonlands National Park, play a distinctive role in linking ecosystems and , in general, provide habitat for a number of organisms. To protect park

Lynn Cudlip; Kevin Berghoff; David Vana-Miller

1999-01-01

499

Pupils and Parks: Environmental Education in National Parks of Developing Countries.  

ERIC Educational Resources Information Center

Describes two conservation education programs that target local primary schools and use national parks in Malaysian Borneo (Kinabalu Park) and central Brazil (Morro do Diabo Park). Both were designed using a comprehensive systems evaluation model and both resulted in cognitive and affective gains for students. (LB)

Jacobson, Susan K.; Padua, Suzana M.

1992-01-01

500

Threats to beach resources and park boundaries caused by shoreline migration in an urban estuarine park  

Microsoft Academic Search

An evaluation of coastal processes, shoreline erosion, and shore management options for Conference House Park, New York, USA, reveals the problems associated with lack of congruence between jurisdictional boundaries and boundaries required for maintenance of beaches and shorefront park land. Rates of shoreline change are high despite low wave energies because bay beaches contain small amounts of sand. The park

Karl F. Nordstrom; Nancy L. Jackson; John P. Tiefenbacher

1990-01-01