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Sample records for large deviation principle

  1. A General Conditional Large Deviation Principle

    NASA Astrophysics Data System (ADS)

    La Cour, Brian R.; Schieve, William C.

    2015-10-01

    Given a sequence of Borel probability measures on a Hausdorff space which satisfy a large deviation principle (LDP), we consider the corresponding sequence of measures formed by conditioning on a set B. If the large deviation rate function I is good and effectively continuous, and the conditioning set has the property that (1) and (2) for all , then the sequence of conditional measures satisfies a LDP with the good, effectively continuous rate function , where if and otherwise.

  2. Large Deviations and Gallavotti-Cohen Principle for Dissipative PDEs with Rough Noise

    NASA Astrophysics Data System (ADS)

    Jakšić, V.; Nersesyan, V.; Pillet, C.-A.; Shirikyan, A.

    2015-05-01

    We study a class of dissipative PDEs perturbed by an unbounded kick force. Under some natural assumptions, the restrictions of solutions to integer times form a homogeneous Markov process. Assuming that the noise is rough with respect to the space variables and has a non-degenerate law, we prove that the system in question satisfies a large deviation principle (LDP) in τ-topology. Under some additional hypotheses, we establish a Gallavotti-Cohen type symmetry for the rate function of an entropy production functional and the strict positivity and finiteness of the mean entropy production rate in the stationary regime. The latter result is applicable to PDEs with strong nonlinear dissipation.

  3. Large Deviations for Finite State Markov Jump Processes with Mean-Field Interaction Via the Comparison Principle for an Associated Hamilton-Jacobi Equation

    NASA Astrophysics Data System (ADS)

    Kraaij, Richard

    2016-07-01

    We prove the large deviation principle (LDP) for the trajectory of a broad class of finite state mean-field interacting Markov jump processes via a general analytic approach based on viscosity solutions. Examples include generalized Ehrenfest models as well as Curie-Weiss spin flip dynamics with singular jump rates. The main step in the proof of the LDP, which is of independent interest, is the proof of the comparison principle for an associated collection of Hamilton-Jacobi equations. Additionally, we show that the LDP provides a general method to identify a Lyapunov function for the associated McKean-Vlasov equation.

  4. Large deviations and portfolio optimization

    NASA Astrophysics Data System (ADS)

    Sornette, Didier

    Risk control and optimal diversification constitute a major focus in the finance and insurance industries as well as, more or less consciously, in our everyday life. We present a discussion of the characterization of risks and of the optimization of portfolios that starts from a simple illustrative model and ends by a general functional integral formulation. A major item is that risk, usually thought of as one-dimensional in the conventional mean-variance approach, has to be addressed by the full distribution of losses. Furthermore, the time-horizon of the investment is shown to play a major role. We show the importance of accounting for large fluctuations and use the theory of Cramér for large deviations in this context. We first treat a simple model with a single risky asset that exemplifies the distinction between the average return and the typical return and the role of large deviations in multiplicative processes, and the different optimal strategies for the investors depending on their size. We then analyze the case of assets whose price variations are distributed according to exponential laws, a situation that is found to describe daily price variations reasonably well. Several portfolio optimization strategies are presented that aim at controlling large risks. We end by extending the standard mean-variance portfolio optimization theory, first within the quasi-Gaussian approximation and then using a general formulation for non-Gaussian correlated assets in terms of the formalism of functional integrals developed in the field theory of critical phenomena.

  5. The large deviation principle and steady-state fluctuation theorem for the entropy production rate of a stochastic process in magnetic fields

    NASA Astrophysics Data System (ADS)

    Chen, Yong; Ge, Hao; Xiong, Jie; Xu, Lihu

    2016-07-01

    Fluctuation theorem is one of the major achievements in the field of nonequilibrium statistical mechanics during the past two decades. There exist very few results for steady-state fluctuation theorem of sample entropy production rate in terms of large deviation principle for diffusion processes due to the technical difficulties. Here we give a proof for the steady-state fluctuation theorem of a diffusion process in magnetic fields, with explicit expressions of the free energy function and rate function. The proof is based on the Karhunen-Loève expansion of complex-valued Ornstein-Uhlenbeck process.

  6. Large Deviations in Fast-Slow Systems

    NASA Astrophysics Data System (ADS)

    Bouchet, Freddy; Grafke, Tobias; Tangarife, Tomás; Vanden-Eijnden, Eric

    2016-02-01

    The incidence of rare events in fast-slow systems is investigated via analysis of the large deviation principle (LDP) that characterizes the likelihood and pathway of large fluctuations of the slow variables away from their mean behavior—such fluctuations are rare on short time-scales but become ubiquitous eventually. Classical results prove that this LDP involves an Hamilton-Jacobi equation whose Hamiltonian is related to the leading eigenvalue of the generator of the fast process, and is typically non-quadratic in the momenta—in other words, the LDP for the slow variables in fast-slow systems is different in general from that of any stochastic differential equation (SDE) one would write for the slow variables alone. It is shown here that the eigenvalue problem for the Hamiltonian can be reduced to a simpler algebraic equation for this Hamiltonian for a specific class of systems in which the fast variables satisfy a linear equation whose coefficients depend nonlinearly on the slow variables, and the fast variables enter quadratically the equation for the slow variables. These results are illustrated via examples, inspired by kinetic theories of turbulent flows and plasma, in which the quasipotential characterizing the long time behavior of the system is calculated and shown again to be different from that of an SDE.

  7. Special ergodic theorems and dynamical large deviations

    NASA Astrophysics Data System (ADS)

    Kleptsyn, Victor; Ryzhov, Dmitry; Minkov, Stanislav

    2012-11-01

    Let f : M → M be a self-map of a compact Riemannian manifold M, admitting a global SRB measure μ. For a continuous test function \\varphi\\colon M\\to R and a constant α > 0, consider the set Kφ,α of the initial points for which the Birkhoff time averages of the function φ differ from its μ-space average by at least α. As the measure μ is a global SRB one, the set Kφ,α should have zero Lebesgue measure. The special ergodic theorem, whenever it holds, claims that, moreover, this set has a Hausdorff dimension less than the dimension of M. We prove that for Lipschitz maps, the special ergodic theorem follows from the dynamical large deviations principle. We also define and prove analogous result for flows. Applying the theorems of Young and of Araújo and Pacifico, we conclude that the special ergodic theorem holds for transitive hyperbolic attractors of C2-diffeomorphisms, as well as for some other known classes of maps (including the one of partially hyperbolic non-uniformly expanding maps) and flows.

  8. Convergence of large-deviation estimators.

    PubMed

    Rohwer, Christian M; Angeletti, Florian; Touchette, Hugo

    2015-11-01

    We study the convergence of statistical estimators used in the estimation of large-deviation functions describing the fluctuations of equilibrium, nonequilibrium, and manmade stochastic systems. We give conditions for the convergence of these estimators with sample size, based on the boundedness or unboundedness of the quantity sampled, and discuss how statistical errors should be defined in different parts of the convergence region. Our results shed light on previous reports of "phase transitions" in the statistics of free energy estimators and establish a general framework for reliably estimating large-deviation functions from simulation and experimental data and identifying parameter regions where this estimation converges. PMID:26651644

  9. Large Deviations: Advanced Probability for Undergrads

    ERIC Educational Resources Information Center

    Rolls, David A.

    2007-01-01

    In the branch of probability called "large deviations," rates of convergence (e.g. of the sample mean) are considered. The theory makes use of the moment generating function. So, particularly for sums of independent and identically distributed random variables, the theory can be made accessible to senior undergraduates after a first course in…

  10. Large deviations for Markov processes with resetting.

    PubMed

    Meylahn, Janusz M; Sabhapandit, Sanjib; Touchette, Hugo

    2015-12-01

    Markov processes restarted or reset at random times to a fixed state or region in space have been actively studied recently in connection with random searches, foraging, and population dynamics. Here we study the large deviations of time-additive functions or observables of Markov processes with resetting. By deriving a renewal formula linking generating functions with and without resetting, we are able to obtain the rate function of such observables, characterizing the likelihood of their fluctuations in the long-time limit. We consider as an illustration the large deviations of the area of the Ornstein-Uhlenbeck process with resetting. Other applications involving diffusions, random walks, and jump processes with resetting or catastrophes are discussed. PMID:26764673

  11. Stochastic quantum Zeno by large deviation theory

    NASA Astrophysics Data System (ADS)

    Gherardini, Stefano; Gupta, Shamik; Saverio Cataliotti, Francesco; Smerzi, Augusto; Caruso, Filippo; Ruffo, Stefano

    2016-01-01

    Quantum measurements are crucial for observing the properties of a quantum system, which, however, unavoidably perturb its state and dynamics in an irreversible way. Here we study the dynamics of a quantum system being subjected to a sequence of projective measurements applied at random times. In the case of independent and identically distributed intervals of time between consecutive measurements, we analytically demonstrate that the survival probability of the system to remain in the projected state assumes a large deviation (exponentially decaying) form in the limit of an infinite number of measurements. This allows us to estimate the typical value of the survival probability, which can therefore be tuned by controlling the probability distribution of the random time intervals. Our analytical results are numerically tested for Zeno-protected entangled states, which also demonstrate that the presence of disorder in the measurement sequence further enhances the survival probability when the Zeno limit is not reached (as it happens in experiments). Our studies provide a new tool for protecting and controlling the amount of quantum coherence in open complex quantum systems by means of tunable stochastic measurements.

  12. Large Deviation Analysis of Rapid Onset of Rain Showers.

    PubMed

    Wilkinson, Michael

    2016-01-01

    Rainfall from ice-free cumulus clouds requires collisions of large numbers of microscopic droplets to create every raindrop. The onset of rain showers can be surprisingly rapid, much faster than the mean time required for a single collision. Large-deviation theory is used to explain this observation. PMID:26799046

  13. Large Deviation Analysis of Rapid Onset of Rain Showers

    NASA Astrophysics Data System (ADS)

    Wilkinson, Michael

    2016-01-01

    Rainfall from ice-free cumulus clouds requires collisions of large numbers of microscopic droplets to create every raindrop. The onset of rain showers can be surprisingly rapid, much faster than the mean time required for a single collision. Large-deviation theory is used to explain this observation.

  14. Large deviations of spread measures for Gaussian matrices

    NASA Astrophysics Data System (ADS)

    Deelan Cunden, Fabio; Vivo, Pierpaolo

    2016-04-01

    For a large n× m Gaussian matrix, we compute the joint statistics, including large deviation tails, of generalized and total variance—the scaled log-determinant H and trace T of the corresponding n× n covariance matrix. Using a Coulomb gas technique, we find that the Laplace transform of their joint distribution {{P}n}(h,t) decays for large n, m (with c=m/n≥slant 1 fixed) as {{\\hat{P}}n}(s,w)≈ \\exp ≤ft(-β {{n}2}J(s,w)\\right) , where β is the Dyson index of the ensemble and J(s, w) is a β-independent large deviation function, which we compute exactly for any c. The corresponding large deviation functions in real space are worked out and checked with extensive numerical simulations. The results are complemented with a finite n, m treatment based on the Laguerre–Selberg integral. The statistics of atypically small log-determinants is shown to be driven by the split-off of the smallest eigenvalue, leading to an abrupt change in the large deviation speed.

  15. Large-deviation statistics of vorticity stretching in isotropic turbulence

    NASA Astrophysics Data System (ADS)

    Johnson, Perry L.; Meneveau, Charles

    2016-03-01

    A key feature of three-dimensional fluid turbulence is the stretching and realignment of vorticity by the action of the strain rate. It is shown in this paper, using the cumulant-generating function, that the cumulative vorticity stretching along a Lagrangian path in isotropic turbulence obeys a large deviation principle. As a result, the relevant statistics can be described by the vorticity stretching Cramér function. This function is computed from a direct numerical simulation data set at a Taylor-scale Reynolds number of Reλ=433 and compared to those of the finite-time Lyapunov exponents (FTLE) for material deformation. As expected, the mean cumulative vorticity stretching is slightly less than that of the most-stretched material line (largest FTLE), due to the vorticity's preferential alignment with the second-largest eigenvalue of strain rate and the material line's preferential alignment with the largest eigenvalue. However, the vorticity stretching tends to be significantly larger than the second-largest FTLE, and the Cramér functions reveal that the statistics of vorticity stretching fluctuations are more similar to those of the largest FTLE. In an attempt to relate the vorticity stretching statistics to the vorticity magnitude probability density function in statistically stationary conditions, a model Kramers-Moyal equation is constructed using the statistics encoded in the Cramér function. The model predicts a stretched-exponential tail for the vorticity magnitude probability density function, with good agreement for the exponent but significant difference (35%) in the prefactor.

  16. Small shape deviations causes complex dynamics in large electric generators

    NASA Astrophysics Data System (ADS)

    Lundström, Niklas L. P.; Grafström, Anton; Aidanpää, Jan-Olov

    2014-05-01

    We prove that combinations of small eccentricity, ovality and/or triangularity in the rotor and stator can produce complex whirling motions of an unbalanced rotor in large synchronous generators. It is concluded which structures of shape deviations that are more harmful, in the sense of producing complex whirling motions, than others. For each such structure, we derive simplified equations of motions from which we conclude analytically the relation between shape deviations and mass unbalance that yield non-smooth whirling motions. Finally we discuss validity of our results in the sense of modeling of the unbalanced magnetic pull force.

  17. Large deviation analysis of a simple information engine.

    PubMed

    Maitland, Michael; Grosskinsky, Stefan; Harris, Rosemary J

    2015-11-01

    Information thermodynamics provides a framework for studying the effect of feedback loops on entropy production. It has enabled the understanding of novel thermodynamic systems such as the information engine, which can be seen as a modern version of "Maxwell's Dæmon," whereby a feedback controller processes information gained by measurements in order to extract work. Here, we analyze a simple model of such an engine that uses feedback control based on measurements to obtain negative entropy production. We focus on the distribution and fluctuations of the information obtained by the feedback controller. Significantly, our model allows an analytic treatment for a two-state system with exact calculation of the large deviation rate function. These results suggest an approximate technique for larger systems, which is corroborated by simulation data. PMID:26651675

  18. From the Law of Large Numbers to Large Deviation Theory in Statistical Physics: An Introduction

    NASA Astrophysics Data System (ADS)

    Cecconi, Fabio; Cencini, Massimo; Puglisi, Andrea; Vergni, Davide; Vulpiani, Angelo

    This contribution aims at introducing the topics of this book. We start with a brief historical excursion on the developments from the law of large numbers to the central limit theorem and large deviations theory. The same topics are then presented using the language of probability theory. Finally, some applications of large deviations theory in physics are briefly discussed through examples taken from statistical mechanics, dynamical and disordered systems.

  19. Irreversible Langevin samplers and variance reduction: a large deviations approach

    NASA Astrophysics Data System (ADS)

    Rey-Bellet, Luc; Spiliopoulos, Konstantinos

    2015-07-01

    In order to sample from a given target distribution (often of Gibbs type), the Monte Carlo Markov chain method consists of constructing an ergodic Markov process whose invariant measure is the target distribution. By sampling the Markov process one can then compute, approximately, expectations of observables with respect to the target distribution. Often the Markov processes used in practice are time-reversible (i.e. they satisfy detailed balance), but our main goal here is to assess and quantify how the addition of a non-reversible part to the process can be used to improve the sampling properties. We focus on the diffusion setting (overdamped Langevin equations) where the drift consists of a gradient vector field as well as another drift which breaks the reversibility of the process but is chosen to preserve the Gibbs measure. In this paper we use the large deviation rate function for the empirical measure as a tool to analyze the speed of convergence to the invariant measure. We show that the addition of an irreversible drift leads to a larger rate function and it strictly improves the speed of convergence of ergodic average for (generic smooth) observables. We also deduce from this result that the asymptotic variance decreases under the addition of the irreversible drift and we give an explicit characterization of the observables whose variance is not reduced reduced, in terms of a nonlinear Poisson equation. Our theoretical results are illustrated and supplemented by numerical simulations.

  20. Locality and nonlocality of classical restrictions of quantum spin systems with applications to quantum large deviations and entanglement

    SciTech Connect

    De Roeck, W. E-mail: christian.maes@fys.kuleuven.be E-mail: marius.schutz@fys.kuleuven.be; Maes, C. E-mail: christian.maes@fys.kuleuven.be E-mail: marius.schutz@fys.kuleuven.be; Schütz, M. E-mail: christian.maes@fys.kuleuven.be E-mail: marius.schutz@fys.kuleuven.be; Netočný, K. E-mail: christian.maes@fys.kuleuven.be E-mail: marius.schutz@fys.kuleuven.be

    2015-02-15

    We study the projection on classical spins starting from quantum equilibria. We show Gibbsianness or quasi-locality of the resulting classical spin system for a class of gapped quantum systems at low temperatures including quantum ground states. A consequence of Gibbsianness is the validity of a large deviation principle in the quantum system which is known and here recovered in regimes of high temperature or for thermal states in one dimension. On the other hand, we give an example of a quantum ground state with strong nonlocality in the classical restriction, giving rise to what we call measurement induced entanglement and still satisfying a large deviation principle.

  1. Boundary driven Kawasaki process with long-range interaction: dynamical large deviations and steady states

    NASA Astrophysics Data System (ADS)

    Mourragui, Mustapha; Orlandi, Enza

    2013-01-01

    A particle system with a single locally-conserved field (density) in a bounded interval with different densities maintained at the two endpoints of the interval is under study here. The particles interact in the bulk through a long-range potential parametrized by β⩾0 and evolve according to an exclusion rule. It is shown that the empirical particle density under the diffusive scaling solves a quasilinear integro-differential evolution equation with Dirichlet boundary conditions. The associated dynamical large deviation principle is proved. Furthermore, when β is small enough, it is also demonstrated that the empirical particle density obeys a law of large numbers with respect to the stationary measures (hydrostatic). The macroscopic particle density solves a non-local, stationary, transport equation.

  2. Interpretation of large-scale deviations from the Hubble flow

    NASA Astrophysics Data System (ADS)

    Grinstein, B.; Politzer, H. David; Rey, S.-J.; Wise, Mark B.

    1987-03-01

    The theoretical expectation for large-scale streaming velocities relative to the Hubble flow is expressed in terms of statistical correlation functions. Only for objects that trace the mass would these velocities have a simple cosmological interpretation. If some biasing effects the objects' formation, then nonlinear gravitational evolution is essential to predicting the expected large-scale velocities, which also depend on the nature of the biasing.

  3. Large deviations of the current in a two-dimensional diffusive system

    SciTech Connect

    Perez-Espigares, C.; Pozo, J. J. del; Garrido, P. L.; Hurtado, P. I.

    2011-03-24

    In this notes we study the large deviations of the time-averaged current in the two-dimensional (2D) Kipnis-Marchioro-Presutti model of energy transport when subject to a boundary gradient. We use the tools of hydrodynamic fluctuation theory, supplemented with an appropriate generalization of the additivity principle. As compared to its one-dimensional counterpart, which amounts to assume that the optimal profiles responsible of a given current fluctuation are time-independent, the 2D additivity conjecture requires an extra assumption, i.e. that the optimal, divergence-free current vector field associated to a given fluctuation of the time-averaged current is in fact constant across the system. Within this context we show that the current distribution exhibits in general non-Gaussian tails. The ensuing optimal density profile can be either monotone for small current fluctuations, or non-monotone with a single maximum for large enough current deviations. Furthermore, this optimal profile remains invariant under arbitrary rotations of the current vector, providing a detailed example of the recently introduced Isometric Fluctuation Relation.

  4. On the concentration of large deviations for fat tailed distributions, with application to financial data

    NASA Astrophysics Data System (ADS)

    Filiasi, Mario; Livan, Giacomo; Marsili, Matteo; Peressi, Maria; Vesselli, Erik; Zarinelli, Elia

    2014-09-01

    Large deviations for fat tailed distributions, i.e. those that decay slower than exponential, are not only relatively likely, but they also occur in a rather peculiar way where a finite fraction of the whole sample deviation is concentrated on a single variable. The regime of large deviations is separated from the regime of typical fluctuations by a phase transition where the symmetry between the points in the sample is spontaneously broken. For stochastic processes with a fat tailed microscopic noise, this implies that, while typical realizations are well described by a diffusion process with continuous sample paths, large deviation paths are typically discontinuous. For eigenvalues of random matrices with fat tailed distributed elements, a large deviation where the trace of the matrix is anomalously large concentrates on just a single eigenvalue, whereas in the thin tailed world the large deviation affects the whole distribution. These results find a natural application to finance. Since the price dynamics of financial stocks are characterized by fat tailed increments, large fluctuations in stock prices are expected to be realized by discrete jumps. Interestingly, we find that large excursions of prices are more likely realized by continuous drifts rather than by discontinuous jumps. Indeed, auto correlations suppress the concentration of large deviations. Financial covariance matrices also exhibit an anomalously large eigenvalue, the market mode, as compared to the prediction of random matrix theory. We show that this is explained by a large deviation with excess covariance rather than by one with excess volatility.

  5. Synchronization of Stochastically Coupled Oscillators: Dynamical Phase Transitions and Large Deviations Theory (or Birds and Frogs)

    NASA Astrophysics Data System (ADS)

    Teodorescu, Razvan

    2009-10-01

    Systems of oscillators coupled non-linearly (stochastically or not) are ubiquitous in nature and can explain many complex phenomena: coupled Josephson junction arrays, cardiac pacemaker cells, swarms or flocks of insects and birds, etc. They are know to have a non-trivial phase diagram, which includes chaotic, partially synchronized, and fully synchronized phases. A traditional model for this class of problems is the Kuramoto system of oscillators, which has been studied extensively for the last three decades. The model is a canonical example for non-equilibrium, dynamical phase transitions, so little understood in physics. From a stochastic analysis point of view, the transition is described by the large deviations principle, which offers little information on the scaling behavior near the critical point. I will discuss a special case of the model, which allows a rigorous analysis of the critical properties of the model, and reveals a new, anomalous scaling behavior in the vicinity of the critical point.

  6. Back in the saddle: Large-deviation statistics of the cosmic log-density field

    NASA Astrophysics Data System (ADS)

    Uhlemann, C.; Codis, S.; Pichon, C.; Bernardeau, F.; Reimberg, P.

    2016-05-01

    We present a first principle approach to obtain analytical predictions for spherically-averaged cosmic densities in the mildly non-linear regime that go well beyond what is usually achieved by standard perturbation theory. A large deviation principle allows us to compute the leading-order cumulants of average densities in concentric cells. In this symmetry, the spherical collapse model leads to cumulant generating functions that are robust for finite variances and free of critical points when logarithmic density transformations are implemented. They yield in turn accurate density probability distribution functions (PDFs) from a straightforward saddle-point approximation valid for all density values. Based on this easy-to-implement modification, explicit analytic formulas for the evaluation of the one- and two-cell PDF are provided. The theoretical predictions obtained for the PDFs are accurate to a few percent compared to the numerical integration, regardless of the density under consideration and in excellent agreement with N-body simulations for a wide range of densities. This formalism should prove valuable for accurately probing the quasi-linear scales of low redshift surveys for arbitrary primordial power spectra.

  7. Back in the saddle: large-deviation statistics of the cosmic log-density field

    NASA Astrophysics Data System (ADS)

    Uhlemann, C.; Codis, S.; Pichon, C.; Bernardeau, F.; Reimberg, P.

    2016-08-01

    We present a first principle approach to obtain analytical predictions for spherically averaged cosmic densities in the mildly non-linear regime that go well beyond what is usually achieved by standard perturbation theory. A large deviation principle allows us to compute the leading order cumulants of average densities in concentric cells. In this symmetry, the spherical collapse model leads to cumulant generating functions that are robust for finite variances and free of critical points when logarithmic density transformations are implemented. They yield in turn accurate density probability distribution functions (PDFs) from a straightforward saddle-point approximation valid for all density values. Based on this easy-to-implement modification, explicit analytic formulas for the evaluation of the one- and two-cell PDF are provided. The theoretical predictions obtained for the PDFs are accurate to a few per cent compared to the numerical integration, regardless of the density under consideration and in excellent agreement with N-body simulations for a wide range of densities. This formalism should prove valuable for accurately probing the quasi-linear scales of low-redshift surveys for arbitrary primordial power spectra.

  8. Two-scale large deviations for chemical reaction kinetics through second quantization path integral

    NASA Astrophysics Data System (ADS)

    Li, Tiejun; Lin, Feng

    2016-04-01

    Motivated by the study of rare events for a typical genetic switching model in systems biology, in this paper we aim to establish the general two-scale large deviations for chemical reaction systems. We build a formal approach to explicitly obtain the large deviation rate functionals for the considered two-scale processes based upon the second quantization path integral technique. We get three important types of large deviation results when the underlying two timescales are in three different regimes. This is realized by singular perturbation analysis to the rate functionals obtained by the path integral. We find that the three regimes possess the same deterministic mean-field limit but completely different chemical Langevin approximations. The obtained results are natural extensions of the classical large volume limit for chemical reactions. We also discuss its implication on the single-molecule Michaelis-Menten kinetics. Our framework and results can be applied to understand general multi-scale systems including diffusion processes.

  9. Large deviations of the shifted index number in the Gaussian ensemble

    NASA Astrophysics Data System (ADS)

    Pérez Castillo, Isaac

    2016-06-01

    We show that, using the Coulomb fluid approach, we are able to derive a rate function \\Psi(c,x) of two variables that captures: (i) the large deviations of bulk eigenvalues; (ii) the large deviations of extreme eigenvalues (both left and right large deviations); (iii) the statistics of the fraction c of eigenvalues to the left of a position x. Thus, \\Psi(c,x) explains the full order statistics of the eigenvalues of large random Gaussian matrices as well as the statistics of the shifted index number. All our analytical findings are thoroughly compared with Monte Carlo simulations, obtaining excellent agreement. A summary of preliminary results has already been presented in Pérez Castillo (2014 Phys. Rev. E 90 040102) in the context of one-dimensional trapped spinless fermions in a harmonic potential.

  10. Efficiency and large deviations in time-asymmetric stochastic heat engines

    DOE PAGESBeta

    Gingrich, Todd R.; Rotskoff, Grant M.; Vaikuntanathan, Suriyanarayanan; Geissler, Phillip L.

    2014-10-24

    In a stochastic heat engine driven by a cyclic non-equilibrium protocol, fluctuations in work and heat give rise to a fluctuating efficiency. Using computer simulations and tools from large deviation theory, we have examined these fluctuations in detail for a model two-state engine. We find in general that the form of efficiency probability distributions is similar to those described by Verley et al (2014 Nat. Commun. 5 4721), in particular featuring a local minimum in the long-time limit. In contrast to the time-symmetric engine protocols studied previously, however, this minimum need not occur at the value characteristic of a reversible Carnot engine. Furthermore, while the local minimum may reside at the global minimum of a large deviation rate function, it does not generally correspond to the least likely efficiency measured over finite time. Lastly, we introduce a general approximation for the finite-time efficiency distribution,more » $$P(\\eta )$$, based on large deviation statistics of work and heat, that remains very accurate even when $$P(\\eta )$$ deviates significantly from its large deviation form.« less

  11. Efficiency and large deviations in time-asymmetric stochastic heat engines

    SciTech Connect

    Gingrich, Todd R.; Rotskoff, Grant M.; Vaikuntanathan, Suriyanarayanan; Geissler, Phillip L.

    2014-10-24

    In a stochastic heat engine driven by a cyclic non-equilibrium protocol, fluctuations in work and heat give rise to a fluctuating efficiency. Using computer simulations and tools from large deviation theory, we have examined these fluctuations in detail for a model two-state engine. We find in general that the form of efficiency probability distributions is similar to those described by Verley et al (2014 Nat. Commun. 5 4721), in particular featuring a local minimum in the long-time limit. In contrast to the time-symmetric engine protocols studied previously, however, this minimum need not occur at the value characteristic of a reversible Carnot engine. Furthermore, while the local minimum may reside at the global minimum of a large deviation rate function, it does not generally correspond to the least likely efficiency measured over finite time. Lastly, we introduce a general approximation for the finite-time efficiency distribution, $P(\\eta )$, based on large deviation statistics of work and heat, that remains very accurate even when $P(\\eta )$ deviates significantly from its large deviation form.

  12. Large Deviations, Guerra's and A.S.S. Schemes, and the Parisi Hypothesis

    NASA Astrophysics Data System (ADS)

    Talagrand, Michel

    2007-03-01

    We investigate the problem of computing lim_{N to infty}1/aNlog EZ_N^a for any value of a, where Z N is the partition function of the celebrated Sherrington-Kirkpatrick (SK) model, or of some of its natural generalizations. This is a natural "large deviation" problem. Its study helps to get a fresh look at some of the recent ideas introduced in the area, and raises a number of natural questions. We provide a complete solution for a ≥ 0.

  13. Multifractal analysis of the irregular set for almost-additive sequences via large deviations

    NASA Astrophysics Data System (ADS)

    Bomfim, Thiago; Varandas, Paulo

    2015-10-01

    In this paper we introduce a notion of free energy and large deviations rate function for asymptotically additive sequences of potentials via an approximation method by families of continuous potentials. We provide estimates for the topological pressure of the set of points whose non-additive sequences are far from the limit described through Kingman’s sub-additive ergodic theorem and give some applications in the context of Lyapunov exponents for diffeomorphisms and cocycles, and the Shannon-McMillan-Breiman theorem for Gibbs measures.

  14. Quadratic and rate-independent limits for a large-deviations functional

    NASA Astrophysics Data System (ADS)

    Bonaschi, Giovanni A.; Peletier, Mark A.

    2016-07-01

    We construct a stochastic model showing the relationship between noise, gradient flows and rate-independent systems. The model consists of a one-dimensional birth-death process on a lattice, with rates derived from Kramers' law as an approximation of a Brownian motion on a wiggly energy landscape. Taking various limits, we show how to obtain a whole family of generalized gradient flows, ranging from quadratic to rate-independent ones, connected via ` L log L' gradient flows. This is achieved via Mosco-convergence of the renormalized large-deviations rate functional of the stochastic process.

  15. Phase Diagram and Density Large Deviations of a Nonconserving ABC Model

    NASA Astrophysics Data System (ADS)

    Cohen, O.; Mukamel, D.

    2012-02-01

    The effect of particle-nonconserving processes on the steady state of driven diffusive systems is studied within the context of a generalized ABC model. It is shown that in the limit of slow nonconserving processes, the large deviation function of the overall particle density can be computed by making use of the steady-state density profile of the conserving model. In this limit one can define a chemical potential and identify first order transitions via Maxwell’s construction, similarly to what is done in equilibrium systems. This method may be applied to other driven models subjected to slow nonconserving dynamics.

  16. A large deviation analysis on the near-equivalence between external and internal reservoirs

    NASA Astrophysics Data System (ADS)

    Medeiros, João R.; Duarte Queirós, Sílvio M.

    2016-06-01

    Within the spirit of van Kampen's "Langevin approach", we discuss the limits of validity of rephrasing the non-equilibrium problem of a particle subject to an external (work) reservoir-a system where the fluctuation-dissipation relation is not verified-into the simpler case with an internal (heat) reservoir for which the fluctuations and the dissipation arise from the same source. Using a convenient mapping of the thermomechanical parameters we show that, counter-intuitively, such approach is not only valid for steady state time independent quantities, but also for time dependent thermostatistical quantities, namely the injected and dissipated fluxes. We connect this result with the problem of large deviations and conclude that, in this context, we can only distinguish reservoirs by analysing the "fluctuations of accumulated fluctuations". As a by-product, we learn that the best reference approximation to the large deviation functions of a non-Markovian external reservoir system is not the respective internal reservoir limit-as often assumed and suggested by the Langevin approach-but its internal reservoir analogue system obtained from the mapping of the original thermomechanical parameters.

  17. Level 2 and level 2.5 large deviation functionals for systems with and without detailed balance

    NASA Astrophysics Data System (ADS)

    Hoppenau, J.; Nickelsen, D.; Engel, A.

    2016-08-01

    Large deviation functions are an essential tool in the statistics of rare events. Often they can be obtained by contraction from a so-called level 2 or level 2.5 large deviation functional characterizing the empirical density and current of the underlying stochastic process. For Langevin systems obeying detailed balance, the explicit form of the level 2 functional has been known ever since the mathematical work of Donsker and Varadhan. We rederive the Donsker–Varadhan result using stochastic path-integrals. We than generalize the derivation to level 2.5 large deviation functionals for non-equilibrium steady states and elucidate the relation between the large deviation functionals and different notions of entropy production in stochastic thermodynamics. Finally, we discuss some aspects of the contractions to level 1 large deviation functions and illustrate our findings with examples.

  18. Large Deviations for Stationary Probabilities of a Family of Continuous Time Markov Chains via Aubry-Mather Theory

    NASA Astrophysics Data System (ADS)

    Lopes, Artur O.; Neumann, Adriana

    2015-05-01

    In the present paper, we consider a family of continuous time symmetric random walks indexed by , . For each the matching random walk take values in the finite set of states ; notice that is a subset of , where is the unitary circle. The infinitesimal generator of such chain is denoted by . The stationary probability for such process converges to the uniform distribution on the circle, when . Here we want to study other natural measures, obtained via a limit on , that are concentrated on some points of . We will disturb this process by a potential and study for each the perturbed stationary measures of this new process when . We disturb the system considering a fixed potential and we will denote by the restriction of to . Then, we define a non-stochastic semigroup generated by the matrix , where is the infinifesimal generator of . From the continuous time Perron's Theorem one can normalized such semigroup, and, then we get another stochastic semigroup which generates a continuous time Markov Chain taking values on . This new chain is called the continuous time Gibbs state associated to the potential , see (Lopes et al. in J Stat Phys 152:894-933, 2013). The stationary probability vector for such Markov Chain is denoted by . We assume that the maximum of is attained in a unique point of , and from this will follow that . Thus, here, our main goal is to analyze the large deviation principle for the family , when . The deviation function , which is defined on , will be obtained from a procedure based on fixed points of the Lax-Oleinik operator and Aubry-Mather theory. In order to obtain the associated Lax-Oleinik operator we use the Varadhan's Lemma for the process . For a careful analysis of the problem we present full details of the proof of the Large Deviation Principle, in the Skorohod space, for such family of Markov Chains, when . Finally, we compute the entropy of the invariant probabilities on the Skorohod space associated to the Markov Chains we analyze.

  19. Topology Trivialization and Large Deviations for the Minimum in the Simplest Random Optimization

    NASA Astrophysics Data System (ADS)

    Fyodorov, Yan V.; Le Doussal, Pierre

    2013-09-01

    Finding the global minimum of a cost function given by the sum of a quadratic and a linear form in N real variables over (N-1)-dimensional sphere is one of the simplest, yet paradigmatic problems in Optimization Theory known as the "trust region subproblem" or "constraint least square problem". When both terms in the cost function are random this amounts to studying the ground state energy of the simplest spherical spin glass in a random magnetic field. We first identify and study two distinct large-N scaling regimes in which the linear term (magnetic field) leads to a gradual topology trivialization, i.e. reduction in the total number {N}_{tot} of critical (stationary) points in the cost function landscape. In the first regime {N}_{tot} remains of the order N and the cost function (energy) has generically two almost degenerate minima with the Tracy-Widom (TW) statistics. In the second regime the number of critical points is of the order of unity with a finite probability for a single minimum. In that case the mean total number of extrema (minima and maxima) of the cost function is given by the Laplace transform of the TW density, and the distribution of the global minimum energy is expected to take a universal scaling form generalizing the TW law. Though the full form of that distribution is not yet known to us, one of its far tails can be inferred from the large deviation theory for the global minimum. In the rest of the paper we show how to use the replica method to obtain the probability density of the minimum energy in the large-deviation approximation by finding both the rate function and the leading pre-exponential factor.

  20. Large Deviations of Radial Statistics in the Two-Dimensional One-Component Plasma

    NASA Astrophysics Data System (ADS)

    Cunden, Fabio Deelan; Mezzadri, Francesco; Vivo, Pierpaolo

    2016-07-01

    The two-dimensional one-component plasma is an ubiquitous model for several vortex systems. For special values of the coupling constant β q^2 (where q is the particles charge and β the inverse temperature), the model also corresponds to the eigenvalues distribution of normal matrix models. Several features of the system are discussed in the limit of large number N of particles for generic values of the coupling constant. We show that the statistics of a class of radial observables produces a rich phase diagram, and their asymptotic behaviour in terms of large deviation functions is calculated explicitly, including next-to-leading terms up to order 1 / N. We demonstrate a split-off phenomenon associated to atypical fluctuations of the edge density profile. We also show explicitly that a failure of the fluid phase assumption of the plasma can break a genuine 1 / N-expansion of the free energy. Our findings are corroborated by numerical comparisons with exact finite-N formulae valid for β q^2=2.

  1. Heterogeneity-induced large deviations in activity and (in some cases) entropy production

    NASA Astrophysics Data System (ADS)

    Gingrich, Todd R.; Vaikuntanathan, Suriyanarayanan; Geissler, Phillip L.

    2014-10-01

    We solve a simple model that supports a dynamic phase transition and show conditions for the existence of the transition. Using methods of large deviation theory we analytically compute the probability distribution for activity and entropy production rates of the trajectories on a large ring with a single heterogeneous link. The corresponding joint rate function demonstrates two dynamical phases—one localized and the other delocalized, but the marginal rate functions do not always exhibit the underlying transition. Symmetries in dynamic order parameters influence the observation of a transition, such that distributions for certain dynamic order parameters need not reveal an underlying dynamical bistability. Solution of our model system furthermore yields the form of the effective Markov transition matrices that generate dynamics in which the two dynamical phases are at coexistence. We discuss the implications of the transition for the response of bacterial cells to antibiotic treatment, arguing that even simple models of a cell cycle lacking an explicit bistability in configuration space will exhibit a bistability of dynamical phases.

  2. Large Deviations of Radial Statistics in the Two-Dimensional One-Component Plasma

    NASA Astrophysics Data System (ADS)

    Cunden, Fabio Deelan; Mezzadri, Francesco; Vivo, Pierpaolo

    2016-09-01

    The two-dimensional one-component plasma is an ubiquitous model for several vortex systems. For special values of the coupling constant β q^2 (where q is the particles charge and β the inverse temperature), the model also corresponds to the eigenvalues distribution of normal matrix models. Several features of the system are discussed in the limit of large number N of particles for generic values of the coupling constant. We show that the statistics of a class of radial observables produces a rich phase diagram, and their asymptotic behaviour in terms of large deviation functions is calculated explicitly, including next-to-leading terms up to order 1 / N. We demonstrate a split-off phenomenon associated to atypical fluctuations of the edge density profile. We also show explicitly that a failure of the fluid phase assumption of the plasma can break a genuine 1 / N-expansion of the free energy. Our findings are corroborated by numerical comparisons with exact finite- N formulae valid for β q^2=2.

  3. Large-deviation joint statistics of the finite-time Lyapunov spectrum in isotropic turbulence

    NASA Astrophysics Data System (ADS)

    Johnson, Perry L.; Meneveau, Charles

    2015-08-01

    One of the hallmarks of turbulent flows is the chaotic behavior of fluid particle paths with exponentially growing separation among them while their distance does not exceed the viscous range. The maximal (positive) Lyapunov exponent represents the average strength of the exponential growth rate, while fluctuations in the rate of growth are characterized by the finite-time Lyapunov exponents (FTLEs). In the last decade or so, the notion of Lagrangian coherent structures (which are often computed using FTLEs) has gained attention as a tool for visualizing coherent trajectory patterns in a flow and distinguishing regions of the flow with different mixing properties. A quantitative statistical characterization of FTLEs can be accomplished using the statistical theory of large deviations, based on the so-called Cramér function. To obtain the Cramér function from data, we use both the method based on measuring moments and measuring histograms and introduce a finite-size correction to the histogram-based method. We generalize the existing univariate formalism to the joint distributions of the two FTLEs needed to fully specify the Lyapunov spectrum in 3D flows. The joint Cramér function of turbulence is measured from two direct numerical simulation datasets of isotropic turbulence. Results are compared with joint statistics of FTLEs computed using only the symmetric part of the velocity gradient tensor, as well as with joint statistics of instantaneous strain-rate eigenvalues. When using only the strain contribution of the velocity gradient, the maximal FTLE nearly doubles in magnitude, highlighting the role of rotation in de-correlating the fluid deformations along particle paths. We also extend the large-deviation theory to study the statistics of the ratio of FTLEs. The most likely ratio of the FTLEs λ1 : λ2 : λ3 is shown to be about 4:1:-5, compared to about 8:3:-11 when using only the strain-rate tensor for calculating fluid volume deformations. The results

  4. Large-deviation joint statistics of the finite-time Lyapunov spectrum in isotropic turbulence

    SciTech Connect

    Johnson, Perry L. Meneveau, Charles

    2015-08-15

    One of the hallmarks of turbulent flows is the chaotic behavior of fluid particle paths with exponentially growing separation among them while their distance does not exceed the viscous range. The maximal (positive) Lyapunov exponent represents the average strength of the exponential growth rate, while fluctuations in the rate of growth are characterized by the finite-time Lyapunov exponents (FTLEs). In the last decade or so, the notion of Lagrangian coherent structures (which are often computed using FTLEs) has gained attention as a tool for visualizing coherent trajectory patterns in a flow and distinguishing regions of the flow with different mixing properties. A quantitative statistical characterization of FTLEs can be accomplished using the statistical theory of large deviations, based on the so-called Cramér function. To obtain the Cramér function from data, we use both the method based on measuring moments and measuring histograms and introduce a finite-size correction to the histogram-based method. We generalize the existing univariate formalism to the joint distributions of the two FTLEs needed to fully specify the Lyapunov spectrum in 3D flows. The joint Cramér function of turbulence is measured from two direct numerical simulation datasets of isotropic turbulence. Results are compared with joint statistics of FTLEs computed using only the symmetric part of the velocity gradient tensor, as well as with joint statistics of instantaneous strain-rate eigenvalues. When using only the strain contribution of the velocity gradient, the maximal FTLE nearly doubles in magnitude, highlighting the role of rotation in de-correlating the fluid deformations along particle paths. We also extend the large-deviation theory to study the statistics of the ratio of FTLEs. The most likely ratio of the FTLEs λ{sub 1} : λ{sub 2} : λ{sub 3} is shown to be about 4:1:−5, compared to about 8:3:−11 when using only the strain-rate tensor for calculating fluid volume

  5. The large deviations of the whitening process in random constraint satisfaction problems

    NASA Astrophysics Data System (ADS)

    Braunstein, Alfredo; Dall’Asta, Luca; Semerjian, Guilhem; Zdeborová, Lenka

    2016-05-01

    Random constraint satisfaction problems undergo several phase transitions as the ratio between the number of constraints and the number of variables is varied. When this ratio exceeds the satisfiability threshold no more solutions exist; the satisfiable phase, for less constrained problems, is itself divided in an unclustered regime and a clustered one. In the latter solutions are grouped in clusters of nearby solutions separated in configuration space from solutions of other clusters. In addition the rigidity transition signals the appearance of so-called frozen variables in typical solutions: beyond this threshold most solutions belong to clusters with an extensive number of variables taking the same values in all solutions of the cluster. In this paper we refine the description of this phenomenon by estimating the location of the freezing transition, corresponding to the disappearance of all unfrozen solutions (not only typical ones). We also unveil phase transitions for the existence and uniqueness of locked solutions, in which all variables are frozen. From a technical point of view we characterize atypical solutions with a number of frozen variables different from the typical value via a large deviation study of the dynamics of a stripping process (whitening) that unveils the frozen variables of a solution, building upon recent works on atypical trajectories of the bootstrap percolation dynamics. Our results also bear some relevance from an algorithmic perspective, previous numerical studies having shown that heuristic algorithms of various kinds usually output unfrozen solutions.

  6. A Thermodynamic Formalism for Continuous Time Markov Chains with Values on the Bernoulli Space: Entropy, Pressure and Large Deviations

    NASA Astrophysics Data System (ADS)

    Lopes, Artur; Neumann, Adriana; Thieullen, Philippe

    2013-09-01

    Through this paper we analyze the ergodic properties of continuous time Markov chains with values on the one-dimensional spin lattice (also known as the Bernoulli space). Initially, we consider as the infinitesimal generator the operator [InlineEquation not available: see fulltext.], where [InlineEquation not available: see fulltext.] is a discrete time Ruelle operator (transfer operator), and is a given fixed Lipschitz function. The associated continuous time stationary Markov chain will define the a priori probability. Given a Lipschitz interaction , we are interested in Gibbs (equilibrium) state for such V. This will be another continuous time stationary Markov chain. In order to analyze this problem we will use a continuous time Ruelle operator (transfer operator) naturally associated to V. Among other things we will show that a continuous time Perron-Frobenius Theorem is true in the case V is a Lipschitz function. We also introduce an entropy, which is negative (see also Lopes et al. in Entropy and Variational Principle for one-dimensional Lattice Systems with a general a-priori probability: positive and zero temperature. Arxiv, 2012), and we consider a variational principle of pressure. Finally, we analyze large deviations properties for the empirical measure in the continuous time setting using results by Y. Kifer (Tamsui Oxf. J. Manag. Sci. 321(2):505-524, 1990). In the last appendix of the paper we explain why the techniques we develop here have the capability to be applied to the analysis of convergence of a certain version of the Metropolis algorithm.

  7. Simulation of heat waves in climate models using large deviation algorithms

    NASA Astrophysics Data System (ADS)

    Ragone, Francesco; Bouchet, Freddy; Wouters, Jeroen

    2016-04-01

    One of the goals of climate science is to characterize the statistics of extreme, potentially dangerous events (e.g. exceptionally intense precipitations, wind gusts, heat waves) in the present and future climate. The study of extremes is however hindered by both a lack of past observational data for events with a return time larger than decades or centuries, and by the large computational cost required to perform a proper sampling of extreme statistics with state of the art climate models. The study of the dynamics leading to extreme events is especially difficult as it requires hundreds or thousands of realizations of the dynamical paths leading to similar extremes. We will discuss here a new numerical algorithm, based on large deviation theory, that allows to efficiently sample very rare events in complex climate models. A large ensemble of realizations are run in parallel, and selection and cloning procedures are applied in order to oversample the trajectories leading to the extremes of interest. The statistics and characteristic dynamics of the extremes can then be computed on a much larger sample of events. This kind of importance sampling method belongs to a class of genetic algorithms that have been successfully applied in other scientific fields (statistical mechanics, complex biomolecular dynamics), allowing to decrease by orders of magnitude the numerical cost required to sample extremes with respect to standard direct numerical sampling. We study the applicability of this method to the computation of the statistics of European surface temperatures with the Planet Simulator (Plasim), an intermediate complexity general circulation model of the atmosphere. We demonstrate the efficiency of the method by comparing its performances against standard approaches. Dynamical paths leading to heat waves are studied, enlightening the relation of Plasim heat waves with blocking events, and the dynamics leading to these events. We then discuss the feasibility of this

  8. Mechanical principles of large mirror supports

    NASA Astrophysics Data System (ADS)

    Kärcher, Hans J.; Eisenträger, Peter; Süss, Martin

    2010-07-01

    Large thin meniscus mirrors use force-controlled shape actuators to obtain the required optical performance. The shape actuators can be interpreted as an advancement of classical mirror supports as whiffle trees or iso-static levers, which worked purely mechanical. The paper develops, after a short historical overview, the theoretical background of mirror mechanics. Different combinations of force-controlled shape actuators with mechanical, hydraulic or pneumatic whiffle trees or iso-static levers are analyzed in regard of their impact on optical performance, dynamic and control behavior. The investigations were the basis for the choice of the shape actuator system for the E-ELT M2, executed by MT Mechatronics under an ESO contract in 2008-09.

  9. Unification of Small and Large Time Scales for Biological Evolution: Deviations from Power Law

    NASA Astrophysics Data System (ADS)

    Chowdhury, Debashish; Stauffer, Dietrich; Kunwar, Ambarish

    2003-02-01

    We develop a unified model that describes both “micro” and “macro” evolutions within a single theoretical framework. The ecosystem is described as a dynamic network; the population dynamics at each node of this network describes the “microevolution” over ecological time scales (i.e., birth, ageing, and natural death of individual organisms), while the appearance of new nodes, the slow changes of the links, and the disappearance of existing nodes accounts for the “macroevolution” over geological time scales (i.e., the origination, evolution, and extinction of species). In contrast to several earlier claims in the literature, we observe strong deviations from power law in the regime of long lifetimes.

  10. Derivation of Stokes' Law from Kirkwood's Formula and the Green-Kubo Formula via Large Deviation Theory

    NASA Astrophysics Data System (ADS)

    Itami, Masato; Sasa, Shin-ichi

    2015-11-01

    We study the friction coefficient of a macroscopic sphere in a viscous fluid at low Reynolds number. First, Kirkwood's formula for the friction coefficient is reviewed on the basis of the Hamiltonian description of particle systems. According to this formula, the friction coefficient is expressed in terms of the stress correlation on the surface of the macroscopic sphere. Then, with the aid of large deviation theory, we relate the surface stress correlation to the stress correlation in the bulk of the fluid, where the latter is characterized by the viscosity in the Green-Kubo formula. By combining Kirkwood's formula and the Green-Kubo formula in large deviation theory, we derive Stokes' law without explicitly employing the hydrodynamic equations.

  11. Extending the Principles of Intensive Writing to Large Macroeconomics Classes

    ERIC Educational Resources Information Center

    Docherty, Peter; Tse, Harry; Forman, Ross; McKenzie, Jo

    2010-01-01

    The authors report on the design and implementation of a pilot program to extend the principles of intensive writing outlined by W. Lee Hansen (1998), Murray S. Simpson and Shireen E. Carroll (1999) and David Carless (2006) to large macroeconomics classes. The key aspect of this program was its collaborative nature, with staff from two specialist…

  12. Scrutiny of non-linear differential equations Euler-Bernoulli beam with large rotational deviation by AGM

    NASA Astrophysics Data System (ADS)

    Akbari, M. R.; Nimafar, M.; Ganji, D. D.; Akbarzade, M. M.

    2014-12-01

    The kinematic assumptions upon which the Euler-Bernoulli beam theory is founded allow it to be extended to more advanced analysis. Simple superposition allows for three-dimensional transverse loading. Using alternative constitutive equations can allow for viscoelastic or plastic beam deformation. Euler-Bernoulli beam theory can also be extended to the analysis of curved beams, beam buckling, composite beams and geometrically nonlinear beam deflection. In this study, solving the nonlinear differential equation governing the calculation of the large rotation deviation of the beam (or column) has been discussed. Previously to calculate the rotational deviation of the beam, the assumption is made that the angular deviation of the beam is small. By considering the small slope in the linearization of the governing differential equation, the solving is easy. The result of this simplification in some cases will lead to an excessive error. In this paper nonlinear differential equations governing on this system are solved analytically by Akbari-Ganji's method (AGM). Moreover, in AGM by solving a set of algebraic equations, complicated nonlinear equations can easily be solved and without any mathematical operations such as integration solving. The solution of the problem can be obtained very simply and easily. Furthermore, to enhance the accuracy of the results, the Taylor expansion is not needed in most cases via AGM manner. Also, comparisons are made between AGM and numerical method (Runge-Kutta 4th). The results reveal that this method is very effective and simple, and can be applied for other nonlinear problems.

  13. Deviations from the fundamental plane of early-type galaxies and large-scale cluster motions

    NASA Astrophysics Data System (ADS)

    Gibbons, Rachel Annette

    2002-11-01

    We fit the fundamental plane, FP, to over 400 early-type galaxies in 20 nearby clusters with cz ˜ 4000 11000 km s -1 using our own photometry and spectroscopy its well as measurements culled from the literature. We find that the duality-of- fit, rms(log σ), to the average fundamental plane, , varies substantially among these clusters. A statistically significant gap in the distribution of rms(log σ) separates the clusters with which fit well from those that do not. The average redshift, of the sample is 7200 km s-1 and the mean redshifts of the two subsamples are 6700 and 8000 km s -1 respectively. Both samples show a mean peculiar velocity of zero, within their errors. However, the 9 high-rms clusters exhibit a significantly higher scatter in their peculiar velocities compared to the other 11 clusters. Assuming early-type galaxies in clusters are drawn from a single underlying population, there should be no correlation between the scatter in peculiar velocity and rms(log σ). The source of the high values of rms(log σ) in this subset of clusters is not entirely known, but these clusters tend to have a problematic combination of intrinsic properties indicative of the presence of substructure, which could potentially bias the measured peculiar velocities. On the other hand, we find that all X-ray bright clusters in our sample fit the well. The evidence suggests that all-sky surveys which mix together both classes of clusters, as characterized by rms(log σ), may artificially inject signal into the observed peculiar velocity field. We therefore suggest using cluster X-ray luminosity or FP scatter to preselect clusters to derive relative distances via the FP. When such a pre-filter is applied to our sample a relatively quiescent Hubble flow is revealed and we are able to rule out some large bulk flows reported by other authors. The resulting subset of clusters exclude the Lauer & Postman (1994) and Willick (1999) frames as the natural rest frame of

  14. Large aperture spatial heterodyne imaging spectrometer: Principle and experimental results

    NASA Astrophysics Data System (ADS)

    Xiangli, Bin; Cai, Qisheng; Du, Shusong

    2015-12-01

    A large aperture spatial heterodyne imaging spectrometer (LASHIS) is proposed. It is a kind of pushbroom Fourier transform ultraspectral imager with no moving parts. This imaging spectrometer, based on a Sagnac lateral shearing interferometer combined with a pair of gratings, has the advantages of high spectral resolution, high throughput and robustness. The principle of LASHIS and its spectral retrieval method are introduced. The processing chain to convert raw images to ultraspectral datacube is also described. Experimental results demonstrate the high resolving power of LASHIS with the emission spectrum of a low pressure sodium lamp.

  15. Deviated Septum

    MedlinePlus

    ... only when he or she also has a "cold" (an upper respiratory tract infection). In these individuals, ... problems related to the deviated septum. Once the "cold" resolves, and the nasal inflammation subsides, symptoms of ...

  16. Large deviations in stochastic heat-conduction processes provide a gradient-flow structure for heat conduction

    SciTech Connect

    Peletier, Mark A.; Redig, Frank; Vafayi, Kiamars

    2014-09-01

    We consider three one-dimensional continuous-time Markov processes on a lattice, each of which models the conduction of heat: the family of Brownian Energy Processes with parameter m (BEP(m)), a Generalized Brownian Energy Process, and the Kipnis-Marchioro-Presutti (KMP) process. The hydrodynamic limit of each of these three processes is a parabolic equation, the linear heat equation in the case of the BEP(m) and the KMP, and a nonlinear heat equation for the Generalized Brownian Energy Process with parameter a (GBEP(a)). We prove the hydrodynamic limit rigorously for the BEP(m), and give a formal derivation for the GBEP(a). We then formally derive the pathwise large-deviation rate functional for the empirical measure of the three processes. These rate functionals imply gradient-flow structures for the limiting linear and nonlinear heat equations. We contrast these gradient-flow structures with those for processes describing the diffusion of mass, most importantly the class of Wasserstein gradient-flow systems. The linear and nonlinear heat-equation gradient-flow structures are each driven by entropy terms of the form -log ρ; they involve dissipation or mobility terms of order ρ² for the linear heat equation, and a nonlinear function of ρ for the nonlinear heat equation.

  17. Large fluctuations of the macroscopic current in diffusive systems: a numerical test of the additivity principle.

    PubMed

    Hurtado, Pablo I; Garrido, Pedro L

    2010-04-01

    Most systems, when pushed out of equilibrium, respond by building up currents of locally conserved observables. Understanding how microscopic dynamics determines the averages and fluctuations of these currents is one of the main open problems in nonequilibrium statistical physics. The additivity principle is a theoretical proposal that allows to compute the current distribution in many one-dimensional nonequilibrium systems. Using simulations, we validate this conjecture in a simple and general model of energy transport, both in the presence of a temperature gradient and in canonical equilibrium. In particular, we show that the current distribution displays a Gaussian regime for small current fluctuations, as prescribed by the central limit theorem, and non-Gaussian (exponential) tails for large current deviations, obeying in all cases the Gallavotti-Cohen fluctuation theorem. In order to facilitate a given current fluctuation, the system adopts a well-defined temperature profile different from that of the steady state and in accordance with the additivity hypothesis predictions. System statistics during a large current fluctuation is independent of the sign of the current, which implies that the optimal profile (as well as higher-order profiles and spatial correlations) are invariant upon current inversion. We also demonstrate that finite-time joint fluctuations of the current and the profile are well described by the additivity functional. These results suggest the additivity hypothesis as a general and powerful tool to compute current distributions in many nonequilibrium systems. PMID:20481672

  18. Large impurity effects in rubrene crystals: First-principles calculations

    SciTech Connect

    Tsetseris, L.; Pantelides, Sokrates T.

    2008-01-01

    Carrier mobilities of rubrene films are among the highest values reported for any organic semiconductor. Here, we probe with first-principles calculations the sensitivity of rubrene crystals on impurities. We find that isolated oxygen impurities create distinct peaks in the electronic density of states consistent with observations of defect levels in rubrene and that increased O content changes the position and shape of rubrene energy bands significantly. We also establish a dual role of hydrogen as individual H species and H impurity pairs create and annihilate deep carrier traps, respectively. The results are relevant to the performance and reliability of rubrene-based devices.

  19. Large vs. Small Lectures in the Principles Course: The Dilemma of the Small Department.

    ERIC Educational Resources Information Center

    Adams, Curtis H.; Britton, Charles R.

    Research results show that there is little loss in student productivity when changing from small lecture classes to large sections in principles of economics courses. A large lecture section of a college level principles of economics course with undergraduate tutors providing personal assistance to students was compared with six classes of 35 to…

  20. Final Technical Report - Large Deviation Methods for the Analysis and Design of Monte Carlo Schemes in Physics and Chemistry - DE-SC0002413

    SciTech Connect

    Dupuis, Paul

    2014-03-14

    This proposal is concerned with applications of Monte Carlo to problems in physics and chemistry where rare events degrade the performance of standard Monte Carlo. One class of problems is concerned with computation of various aspects of the equilibrium behavior of some Markov process via time averages. The problem to be overcome is that rare events interfere with the efficient sampling of all relevant parts of phase space. A second class concerns sampling transitions between two or more stable attractors. Here, rare events do not interfere with the sampling of all relevant parts of phase space, but make Monte Carlo inefficient because of the very large number of samples required to obtain variance comparable to the quantity estimated. The project uses large deviation methods for the mathematical analyses of various Monte Carlo techniques, and in particular for algorithmic analysis and design. This is done in the context of relevant application areas, mainly from chemistry and biology.

  1. Bioinspired Principles for Large-Scale Networked Sensor Systems: An Overview

    PubMed Central

    Jacobsen, Rune Hylsberg; Zhang, Qi; Toftegaard, Thomas Skjødeberg

    2011-01-01

    Biology has often been used as a source of inspiration in computer science and engineering. Bioinspired principles have found their way into network node design and research due to the appealing analogies between biological systems and large networks of small sensors. This paper provides an overview of bioinspired principles and methods such as swarm intelligence, natural time synchronization, artificial immune system and intercellular information exchange applicable for sensor network design. Bioinspired principles and methods are discussed in the context of routing, clustering, time synchronization, optimal node deployment, localization and security and privacy. PMID:22163841

  2. Characterizing Coherent Wind Structures using Large-Scale Particle Tracking Velocimetry: A Proof-of-Principle Study

    NASA Astrophysics Data System (ADS)

    Rosi, G. A.; la Bastide, B.; Gaebler, J.; Kinzel, M.; Rival, D. E.

    2014-12-01

    The following study proposes a two-dimensional large-scale particle tracking velocimetry (LS-PTV) system to characterize coherent wind structures. Seven minutes of LS-PTV data is collected via an apparatus that seeds fog-filled soap bubbles into the wind at a height of 6m from the ground. The LS-PTV data is compared to 20 minutes of data collected concurrently from a wind mast at the same site. The LS-PTV system recorded a mean streamwise velocity of 1.35m/s with a standard deviation of 0.23m/s at a mean height of 2.50m with a standard deviation of 0.7m, which agrees well with the velocity profile measured by the wind mast. Furthermore, the Reynolds stresses measured by the LS-PTV system are found to compare to those measured by the wind mast and by Klebanoff [1] for a canonical turbulent boundary layer. The current study assumes that the centre-of-curvature trajectories of the particle pathlines are representative of the trajectories followed by the spanwise vortices. As a proof-of-principle study, this work has been successful in accurately describing the vortex distribution very near to the ground. However, the trajectories followed by the centres-of- curvat.ure belonging to pathlines concurrently passing through the field-of-view were sporadic and uncorrelated.

  3. Coarse Grained Approach to First Principles Modeling of Radiation Cascade in Large Fe Supercells

    NASA Astrophysics Data System (ADS)

    Odbadrakh, Kh; Nicholson, D. M.; Rusanu, A.; Samolyuk, G. D.; Stoller, R. E.; Zhang, X.-G.; Stocks, G. M.

    2012-12-01

    Classical Molecular Dynamics (MD) simulations characterizing dislocations and radiation damage typically treat 105-107 atoms. First principles techniques employed to understand systems at an atomistic level are not practical for such large systems consisting of millions of atoms. We present an efficient coarse grained (CG) approach to calculate local electronic and magnetic properties of large MD-generated structures from the first principles. Local atomic magnetic moments in crystalline Fe are perturbed by the presence of radiation generated vacancies and interstitials. The effects are most pronounced near the defect cores and decay slowly as the strain field of the defects decrease with distance. We develop the CG technique based on the Locally Self-consistent Multiple Scattering (LSMS) method that exploits the near-sightedness of the electron Green function. The atomic positions were determined by MD with an embedded atom force field. The local moments in the neighborhood of the defect cores are calculated with first-principles based on full local structure information. Atoms in the rest of the system are modeled by representative atoms with approximated properties. The calculations result in local moments near the defect centers with first-principles accuracy, while capturing coarse-grained details of local moments at greater length scales. This CG approach makes these large scale structures amenable to first principles study.

  4. Implementing the "Marketing You" Project in Large Sections of Principles of Marketing

    ERIC Educational Resources Information Center

    Smith, Karen H.

    2004-01-01

    There is mounting pressure on business education to increase experiential learning at the same time that budget constraints are forcing universities to increase class size. This article explains the design and implementation of the "Marketing You" project in two large sections of Principles of Marketing to bring experiential learning into the…

  5. Convergence of the probability of large deviations in a model of correlated random variables having compact-support Q-Gaussians as limiting distributions

    NASA Astrophysics Data System (ADS)

    Jauregui, Max; Tsallis, Constantino

    2015-02-01

    We consider correlated random variables X1, …, Xn taking values in {0, 1} such that, for any permutation π of {1, …, n}, the random vectors (X1, …, Xn) and (Xπ(1), …, Xπ(n)) have the same distribution. This distribution, which was introduced by Rodríguez et al. [J. Stat. Mech. 2008, P09006] and then generalized by Hanel et al. [Eur. Phys. J. B 72, 263 (2009)], is scale-invariant and depends on a real parameter ν > 0 (ν → ∞ implies independence). Putting Sn = X1 + ⋯ + Xn, the distribution of Sn - n/2 approaches a Q-Gaussian distribution with compact support (Q = 1 - 1/(ν - 1) < 1) as n increases, after appropriate scaling. In the present article, we show that the distribution of Sn/n converges, as n → ∞, to a beta distribution with both parameters equal to ν. In particular, the law of large numbers does not hold since, if 0 ≤ x < 1/2, then ℙ(Sn/n ≤ x), which is the probability of the event {Sn/n ≤ x} (large deviation), does not converge to zero as n → ∞. For x = 0 and every real ν > 0, we show that ℙ(Sn = 0) decays to zero like a power law of the form 1/nν with a subdominant term of the form 1/nν+1. If 0 < x ≤ 1 and ν > 0 is an integer, we show that we can analytically find upper and lower bounds for the difference between ℙ(Sn/n ≤ x) and its (n → ∞) limit. We also show that these bounds vanish like a power law of the form 1/n with a subdominant term of the form 1/n2.

  6. On Large Time Behavior and Selection Principle for a Diffusive Carr-Penrose Model

    NASA Astrophysics Data System (ADS)

    Conlon, Joseph G.; Dabkowski, Michael; Wu, Jingchen

    2016-04-01

    This paper is concerned with the study of a diffusive perturbation of the linear LSW model introduced by Carr and Penrose. A main subject of interest is to understand how the presence of diffusion acts as a selection principle, which singles out a particular self-similar solution of the linear LSW model as determining the large time behavior of the diffusive model. A selection principle is rigorously proven for a model which is a semiclassical approximation to the diffusive model. Upper bounds on the rate of coarsening are also obtained for the full diffusive model.

  7. Dissociated Vertical Deviation

    MedlinePlus

    ... Eye Terms Conditions Frequently Asked Questions Español Condiciones Chinese Conditions Dissociated Vertical Deviation En Español Read in Chinese What is Dissociated Vertical Deviation (DVD)? DVD is ...

  8. Large-Scale First-Principles Molecular Dynamics Simulations with Electrostatic Embedding: Application to Acetylcholinesterase Catalysis

    DOE PAGESBeta

    Fattebert, Jean-Luc; Lau, Edmond Y.; Bennion, Brian J.; Huang, Patrick; Lightstone, Felice C.

    2015-10-22

    Enzymes are complicated solvated systems that typically require many atoms to simulate their function with any degree of accuracy. We have recently developed numerical techniques for large scale First-Principles molecular dynamics simulations and applied them to study the enzymatic reaction catalyzed by acetylcholinesterase. We carried out Density functional theory calculations for a quantum mechanical (QM) sub- system consisting of 612 atoms with an O(N) complexity finite-difference approach. The QM sub-system is embedded inside an external potential field representing the electrostatic effect due to the environment. We obtained finite temperature sampling by First-Principles molecular dynamics for the acylation reaction of acetylcholinemore » catalyzed by acetylcholinesterase. Our calculations shows two energies barriers along the reaction coordinate for the enzyme catalyzed acylation of acetylcholine. In conclusion, the second barrier (8.5 kcal/mole) is rate-limiting for the acylation reaction and in good agreement with experiment.« less

  9. Large-Scale First-Principles Molecular Dynamics Simulations with Electrostatic Embedding: Application to Acetylcholinesterase Catalysis

    SciTech Connect

    Fattebert, Jean-Luc; Lau, Edmond Y.; Bennion, Brian J.; Huang, Patrick; Lightstone, Felice C.

    2015-10-22

    Enzymes are complicated solvated systems that typically require many atoms to simulate their function with any degree of accuracy. We have recently developed numerical techniques for large scale First-Principles molecular dynamics simulations and applied them to study the enzymatic reaction catalyzed by acetylcholinesterase. We carried out Density functional theory calculations for a quantum mechanical (QM) sub- system consisting of 612 atoms with an O(N) complexity finite-difference approach. The QM sub-system is embedded inside an external potential field representing the electrostatic effect due to the environment. We obtained finite temperature sampling by First-Principles molecular dynamics for the acylation reaction of acetylcholine catalyzed by acetylcholinesterase. Our calculations shows two energies barriers along the reaction coordinate for the enzyme catalyzed acylation of acetylcholine. In conclusion, the second barrier (8.5 kcal/mole) is rate-limiting for the acylation reaction and in good agreement with experiment.

  10. Requirements and principles for the implementation and construction of large-scale geographic information systems

    NASA Technical Reports Server (NTRS)

    Smith, Terence R.; Menon, Sudhakar; Star, Jeffrey L.; Estes, John E.

    1987-01-01

    This paper provides a brief survey of the history, structure and functions of 'traditional' geographic information systems (GIS), and then suggests a set of requirements that large-scale GIS should satisfy, together with a set of principles for their satisfaction. These principles, which include the systematic application of techniques from several subfields of computer science to the design and implementation of GIS and the integration of techniques from computer vision and image processing into standard GIS technology, are discussed in some detail. In particular, the paper provides a detailed discussion of questions relating to appropriate data models, data structures and computational procedures for the efficient storage, retrieval and analysis of spatially-indexed data.

  11. Large-scale brain networks in cognition: emerging methods and principles.

    PubMed

    Bressler, Steven L; Menon, Vinod

    2010-06-01

    An understanding of how the human brain produces cognition ultimately depends on knowledge of large-scale brain organization. Although it has long been assumed that cognitive functions are attributable to the isolated operations of single brain areas, we demonstrate that the weight of evidence has now shifted in support of the view that cognition results from the dynamic interactions of distributed brain areas operating in large-scale networks. We review current research on structural and functional brain organization, and argue that the emerging science of large-scale brain networks provides a coherent framework for understanding of cognition. Critically, this framework allows a principled exploration of how cognitive functions emerge from, and are constrained by, core structural and functional networks of the brain. PMID:20493761

  12. Thermal Conductivity and Large Isotope Effect in GaN from First Principles

    SciTech Connect

    Lindsay, L.; Broido, D. A.; Reinecke, T. L.

    2012-08-28

    We present atomistic first principles results for the lattice thermal conductivity of GaN and compare them to those for GaP, GaAs, and GaSb. In GaN we find a large increase to the thermal conductivity with isotopic enrichment, ~65% at room temperature. We show that both the high thermal conductivity and its enhancement with isotopic enrichment in GaN arise from the weak coupling of heat-carrying acoustic phonons with optic phonons. This weak scattering results from stiff atomic bonds and the large Ga to N mass ratio, which give phonons high frequencies and also a pronounced energy gap between acoustic and optic phonons compared to other materials. Rigorous understanding of these features in GaN gives important insights into the interplay between intrinsic phonon-phonon scattering and isotopic scattering in a range of materials.

  13. The Force-From-Lipid (FFL) principle of mechanosensitivity, at large and in elements

    PubMed Central

    Teng, Jinfeng; Loukin, Stephen; Anishkin, Andriy; Kung, Ching

    2014-01-01

    Focus on touch and hearing distracts attention from numerous subconscious force sensors such as the vital control of blood pressure, systemic osmolarity, etc. and sensors in non-animals. Multifarious manifestations should not obscure invariant and fundamental physico-chemical principles. We advocate that force-from-lipid (FFL) is one such principle. It is based on the fact that the self-assembled bilayer necessitates inherent forces that are large, and anisotropic, even at life’s origin. Functional response of membrane proteins is governed by bilayer-force changes. Added stress can redirect these forces, leading to geometric changes of embedded proteins such as ion channels. The FFL principle was first demonstrated when purified bacterial MscL remained mechanosensitive (MS) after reconstituting into bilayers. This key experiment has recently been unequivocally replicated with two vertebrate MS K2p channels. Even the canonical Kv and the Drosophila TRPCs have now been shown to be MS in biophysical and in physiological contexts, supporting the universality of the FFL paradigm. We also review the deterministic role of mechanical force during stem-cell differentiation as well as the cell-cell and cell-matrix tethers that provide force communications. In both the ear hair cell and the worm’s touch neuron, deleting the cadherin or microtubule tethers reduces but does not eliminate MS-channel activities. We found no evidence to distinguish whether these tethers directly pulls on the channel protein or a surrounding lipid platform. Regardless of the implementation, pulling tether tenses up the bilayer. Membrane tenting is directly visible at the apexes of the stereocilia. PMID:24888690

  14. Jump rates for surface diffusion of large molecules from first principles

    SciTech Connect

    Shea, Patrick Kreuzer, Hans Jürgen

    2015-04-21

    We apply a recently developed stochastic model for the surface diffusion of large molecules to calculate jump rates for 9,10-dithioanthracene on a Cu(111) surface. The necessary input parameters for the stochastic model are calculated from first principles using density functional theory (DFT). We find that the inclusion of van der Waals corrections to the DFT energies is critical to obtain good agreement with experimental results for the adsorption geometry and energy barrier for diffusion. The predictions for jump rates in our model are in excellent agreement with measured values and show a marked improvement over transition state theory (TST). We find that the jump rate prefactor is reduced by an order of magnitude from the TST estimate due to frictional damping resulting from energy exchange with surface phonons, as well as a rotational mode of the diffusing molecule.

  15. Single-field consistency relations of large scale structure part III: test of the equivalence principle

    SciTech Connect

    Creminelli, Paolo; Gleyzes, Jérôme; Vernizzi, Filippo; Hui, Lam; Simonović, Marko E-mail: jerome.gleyzes@cea.fr E-mail: msimonov@sissa.it

    2014-06-01

    The recently derived consistency relations for Large Scale Structure do not hold if the Equivalence Principle (EP) is violated. We show it explicitly in a toy model with two fluids, one of which is coupled to a fifth force. We explore the constraints that galaxy surveys can set on EP violation looking at the squeezed limit of the 3-point function involving two populations of objects. We find that one can explore EP violations of order 10{sup −3}÷10{sup −4} on cosmological scales. Chameleon models are already very constrained by the requirement of screening within the Solar System and only a very tiny region of the parameter space can be explored with this method. We show that no violation of the consistency relations is expected in Galileon models.

  16. Integration of human factors principles in LARG organizations--a conceptual model.

    PubMed

    Figueira, Sara; Machado, V Cruz; Nunes, Isabel L

    2012-01-01

    Nowadays many companies are undergoing organizational transformations in order to meet the changing market demands. Thus, in order to become more competitive, supply chains (SC) are adopting new management paradigms to improve SC performance: lean, agile, resilient and green (LARG paradigms). The implementation of new production paradigms demands particular care with the issues related with Human Factors to avoid health and safety problems to workers and losses to companies. Thus, the successful introduction of these new production paradigms depends among others on a Human Factors oriented approach. This work presents a conceptual framework that allows integrating ergonomic and safety design principles during the different implementation phases of lean, agile, resilient and green practices. PMID:22316960

  17. A method of orbital analysis for large-scale first-principles simulations

    SciTech Connect

    Ohwaki, Tsukuru; Otani, Minoru; Ozaki, Taisuke

    2014-06-28

    An efficient method of calculating the natural bond orbitals (NBOs) based on a truncation of the entire density matrix of a whole system is presented for large-scale density functional theory calculations. The method recovers an orbital picture for O(N) electronic structure methods which directly evaluate the density matrix without using Kohn-Sham orbitals, thus enabling quantitative analysis of chemical reactions in large-scale systems in the language of localized Lewis-type chemical bonds. With the density matrix calculated by either an exact diagonalization or O(N) method, the computational cost is O(1) for the calculation of NBOs associated with a local region where a chemical reaction takes place. As an illustration of the method, we demonstrate how an electronic structure in a local region of interest can be analyzed by NBOs in a large-scale first-principles molecular dynamics simulation for a liquid electrolyte bulk model (propylene carbonate + LiBF{sub 4})

  18. Large magnetocrystalline anisotropy in bilayer transition metal phases from first-principles full-potential calculations

    NASA Astrophysics Data System (ADS)

    Ravindran, P.; Kjekshus, A.; Fjellvåg, H.; James, P.; Nordström, L.; Johansson, B.; Eriksson, O.

    2001-04-01

    The computational framework of this study is based on the local-spin-density approximation with first-principles full-potential linear muffin-tin orbital calculations including orbital polarization (OP) correction. We have studied the magnetic anisotropy for a series of bilayer CuAu(I)-type materials such as FeX, MnX (X=Ni,Pd,Pt), CoPt, NiPt, MnHg, and MnRh in a ferromagnetic state using experimental structural parameters to understand the microscopic origin of magnetic-anisotropy energy (MAE) in magnetic multilayers. Except for MnRh and MnHg, all these phases show perpendicular magnetization. We have analyzed our results in terms of angular momentum-, spin- and site-projected density of states, magnetic-angular-momentum-projected density of states, orbital-moment density of states, and total density of states. The orbital-moment number of states and the orbital-moment anisotropy for FeX (X=Ni,Pd,Pt) are calculated as a function of band filling to study its effect on MAE. The total and site-projected spin and orbital moments for all these systems are calculated with and without OP when the magnetization is along or perpendicular to the plane. The results are compared with available experimental as well as theoretical results. Our calculations show that OP always enhances the orbital moment in these phases and brings them closer to experimental values. The changes in MAE are analyzed in terms of exchange splitting, spin-orbit splitting, and tetragonal distortion/crystal-field splitting. The calculated MAE is found to be in good agreement with experimental values when the OP correction is included. Some of the materials considered here show large magnetic anisotropy of the order of meV. In particular we found that MnPt will have a very large MAE if it could be stabilized in a ferromagnetic configuration. Our analysis indicates that apart from large spin-orbit interaction and exchange interaction from at least one of the constituents, a large crystal-field splitting

  19. Subpixelic measurement of large 1D displacements: principle, processing algorithms, performances and software.

    PubMed

    Guelpa, Valérian; Laurent, Guillaume J; Sandoz, Patrick; Zea, July Galeano; Clévy, Cédric

    2014-01-01

    This paper presents a visual measurement method able to sense 1D rigid body displacements with very high resolutions, large ranges and high processing rates. Sub-pixelic resolution is obtained thanks to a structured pattern placed on the target. The pattern is made of twin periodic grids with slightly different periods. The periodic frames are suited for Fourier-like phase calculations-leading to high resolution-while the period difference allows the removal of phase ambiguity and thus a high range-to-resolution ratio. The paper presents the measurement principle as well as the processing algorithms (source files are provided as supplementary materials). The theoretical and experimental performances are also discussed. The processing time is around 3 µs for a line of 780 pixels, which means that the measurement rate is mostly limited by the image acquisition frame rate. A 3-σ repeatability of 5 nm is experimentally demonstrated which has to be compared with the 168 µm measurement range. PMID:24625736

  20. Electrostatic embedding in large-scale first principles quantum mechanical calculations on biomolecules.

    PubMed

    Fox, Stephen J; Pittock, Chris; Fox, Thomas; Tautermann, Christofer S; Malcolm, Noj; Skylaris, Chris-Kriton

    2011-12-14

    Biomolecular simulations with atomistic detail are often required to describe interactions with chemical accuracy for applications such as the calculation of free energies of binding or chemical reactions in enzymes. Force fields are typically used for this task but these rely on extensive parameterisation which in cases can lead to limited accuracy and transferability, for example for ligands with unusual functional groups. These limitations can be overcome with first principles calculations with methods such as density functional theory (DFT) but at a much higher computational cost. The use of electrostatic embedding can significantly reduce this cost by representing a portion of the simulated system in terms of highly localised charge distributions. These classical charge distributions are electrostatically coupled with the quantum system and represent the effect of the environment in which the quantum system is embedded. In this paper we describe and evaluate such an embedding scheme in which the polarisation of the electronic density by the embedding charges occurs self-consistently during the calculation of the density. We have implemented this scheme in a linear-scaling DFT program as our aim is to treat with DFT entire biomolecules (such as proteins) and large portions of the solvent. We test this approach in the calculation of interaction energies of ligands with biomolecules and solvent and investigate under what conditions these can be obtained with the same level of accuracy as when the entire system is described by DFT, for a variety of neutral and charged species. PMID:22168680

  1. Caudal septal deviation.

    PubMed

    Haack, Jason; Papel, Ira D

    2009-06-01

    The nasal septum is a structure poorly understood and appreciated by the lay public and the nonotolaryngologist--head and neck surgeon alike. Deviation of the caudal portion of the nasal septum may result in nasal obstruction, a crooked nose, and columellar irregularities. The correction of a severely deviated caudal septum is one of the most difficult challenges of the otolaryngologist and facial plastic surgeon. A variety of options are available for correction of mild, to the most severe, deflections. This condition, as with all challenges in medicine, should not be a one size fits all or one surgery fits all situation. The skilled surgeon should understand the multiple options available for surgical correction and tailor fit the procedure to the deformity. PMID:19486740

  2. Testing deviations from ΛCDM with growth rate measurements from six large-scale structure surveys at z = 0.06-1

    NASA Astrophysics Data System (ADS)

    Alam, Shadab; Ho, Shirley; Silvestri, Alessandra

    2016-03-01

    We use measurements from the Planck satellite mission and galaxy redshift surveys over the last decade to test three of the basic assumptions of the standard model of cosmology, ΛCDM (Λ cold dark matter): the spatial curvature of the universe, the nature of dark energy and the laws of gravity on large scales. We obtain improved constraints on several scenarios that violate one or more of these assumptions. We measure w0 = -0.94 ± 0.17 (18 per cent measurement) and 1 + wa = 1.16 ± 0.36 (31 per cent measurement) for models with a time-dependent equation of state, which is an improvement over current best constraints. In the context of modified gravity, we consider popular scalar-tensor models as well as a parametrization of the growth factor. In the case of one-parameter f(R) gravity models with a ΛCDM background, we constrain B0 < 1.36 × 10-5 (1σ C.L.), which is an improvement by a factor of 4 on the current best. We provide the very first constraint on the coupling parameters of general scalar-tensor theory and stringent constraint on the only free coupling parameter of Chameleon models. We also derive constraints on extended Chameleon models, improving the constraint on the coupling by a factor of 6 on the current best. The constraints on coupling parameter for Chameleon model rule out the value of β1 = 4/3 required for f(R) gravity. We also measure γ = 0.612 ± 0.072 (11.7 per cent measurement) for growth index parametrization. We improve all the current constraints by combining results from various galaxy redshift surveys in a coherent way, which includes a careful treatment of scale dependence introduced by modified gravity.

  3. Clickenomics: Using a Classroom Response System to Increase Student Engagement in a Large-Enrollment Principles of Economics Course

    ERIC Educational Resources Information Center

    Salemi, Michael K.

    2009-01-01

    One of the most important challenges facing college instructors of economics is helping students engage. Engagement is particularly important in a large-enrollment Principles of Economics course, where it can help students achieve a long-lived understanding of how economists use basic economic ideas to look at the world. The author reports how…

  4. Large-Scale First-Principles Molecular Dynamics Simulations on the BlueGene/L Platform using the Qbox Code

    SciTech Connect

    Gygi, F; Draeger, E W; de Supinski, B R; Yates, R K; Franchetti, F; Kral, S; Lorenz, J; Ueberhuber, C; Gunnels, J A; Sexton, J C

    2005-04-25

    We demonstrate that the Qbox code supports unprecedented large-scale First-Principles Molecular Dynamics (FPMD) applications on the BlueGene/L supercomputer. Qbox is an FPMD implementation specifically designed for large-scale parallel platforms such as BlueGene/L. Strong scaling tests for a Materials Science application show an 86% scaling efficiency between 1024 and 32,768 CPUs. Measurements of performance by means of hardware counters show that 37% of the peak FPU performance can be attained.

  5. Power fluctuations, large deviations and turbulence

    SciTech Connect

    Bandi, Mahesh M; Chumakov, Sergei; Connaughton, Colm P

    2008-01-01

    We study local power fluctuations in numerical simulations of stationary, homogenous, isotropic turbulence in two and three dimensions with Gaussian forcing. Due to the near-Gaussianity of the one-point velocity distribution, the probability distribution function (pdf) of the local power is well modeled by the pdf of the product of two joint normally distributed variables. In appropriate units, this distribution is calculated exactly and shown to satisfy a Fluctuation Relation (FR) with a coefficient which depends on {epsilon}.

  6. Pleasure and pain: teaching neuroscientific principles of hedonism in a large general education undergraduate course.

    PubMed

    Bodnar, Richard J; Stellar, James R; Kraft, Tamar T; Loiacono, Ilyssa; Bajnath, Adesh; Rotella, Francis M; Barrientos, Alicia; Aghanori, Golshan; Olsson, Kerstin; Coke, Tricia; Huang, Donald; Luger, Zeke; Mousavi, Seyed Ali Reza; Dindyal, Trisha; Naqvi, Naveen; Kim, Jung-Yo

    2013-01-01

    In a large (250 registrants) general education lecture course, neuroscience principles were taught by two professors as co-instructors, starting with simple brain anatomy, chemistry, and function, proceeding to basic brain circuits of pleasure and pain, and progressing with fellow expert professors covering relevant philosophical, artistic, marketing, and anthropological issues. With this as a base, the course wove between fields of high relevance to psychology and neuroscience, such as food addiction and preferences, drug seeking and craving, analgesic pain-inhibitory systems activated by opiates and stress, neuroeconomics, unconscious decision-making, empathy, and modern neuroscientific techniques (functional magnetic resonance imaging and event-related potentials) presented by the co-instructors and other Psychology professors. With no formal assigned textbook, all lectures were PowerPoint-based, containing links to supplemental public-domain material. PowerPoints were available on Blackboard several days before the lecture. All lectures were also video-recorded and posted that evening. The course had a Facebook page for after-class conversation and one of the co-instructors communicated directly with students on Twitter in real time during lecture to provide momentary clarification and comment. In addition to graduate student Teaching Assistants (TAs), to allow for small group discussion, ten undergraduate students who performed well in a previous class were selected to serve as discussion leaders. The Discussion Leaders met four times at strategic points over the semester with groups of 20-25 current students, and received one credit of Independent Study, thus creating a course within a course. The course grade was based on weighted scores from two multiple-choice exams and a five-page writing assignment in which each student reviewed three unique, but brief original peer-review research articles (one page each) combined with expository writing on the first

  7. Pleasure and Pain: Teaching Neuroscientific Principles of Hedonism in a Large General Education Undergraduate Course

    PubMed Central

    Bodnar, Richard J.; Stellar, James R.; Kraft, Tamar T.; Loiacono, Ilyssa; Bajnath, Adesh; Rotella, Francis M.; Barrientos, Alicia; Aghanori, Golshan; Olsson, Kerstin; Coke, Tricia; Huang, Donald; Luger, Zeke; Mousavi, Seyed Ali Reza; Dindyal, Trisha; Naqvi, Naveen; Kim, Jung-Yo

    2013-01-01

    In a large (250 registrants) general education lecture course, neuroscience principles were taught by two professors as co-instructors, starting with simple brain anatomy, chemistry, and function, proceeding to basic brain circuits of pleasure and pain, and progressing with fellow expert professors covering relevant philosophical, artistic, marketing, and anthropological issues. With this as a base, the course wove between fields of high relevance to psychology and neuroscience, such as food addiction and preferences, drug seeking and craving, analgesic pain-inhibitory systems activated by opiates and stress, neuroeconomics, unconscious decision-making, empathy, and modern neuroscientific techniques (functional magnetic resonance imaging and event-related potentials) presented by the co-instructors and other Psychology professors. With no formal assigned textbook, all lectures were PowerPoint-based, containing links to supplemental public-domain material. PowerPoints were available on Blackboard several days before the lecture. All lectures were also video-recorded and posted that evening. The course had a Facebook page for after-class conversation and one of the co-instructors communicated directly with students on Twitter in real time during lecture to provide momentary clarification and comment. In addition to graduate student Teaching Assistants (TAs), to allow for small group discussion, ten undergraduate students who performed well in a previous class were selected to serve as discussion leaders. The Discussion Leaders met four times at strategic points over the semester with groups of 20–25 current students, and received one credit of Independent Study, thus creating a course within a course. The course grade was based on weighted scores from two multiple-choice exams and a five-page writing assignment in which each student reviewed three unique, but brief original peer-review research articles (one page each) combined with expository writing on the first

  8. Large-Scale First-Principles Molecular Dynamics Simulations on the BlueGene/L Platform using the Qbox Code

    SciTech Connect

    Gygi, F; Draeger, E; de Supinski, B; Yates, R K; Franchetti, F; Kral, S; Lorenz, J; Ueberhueber, C; Gunnels, J A; Sexton, J

    2006-01-04

    First-Principles Molecular Dynamics (FPMD) is an accurate, atomistic simulation approach that is routinely applied to a variety of areas including solid-state physics, chemistry, biochemistry and nanotechnology. FPMD enables one to perform predictive materials simulations, as no empirical or adjustable parameters are used to describe a given system. Instead, a quantum mechanical description of electrons is obtained by solving the Kohn-Sham equations within a pseudopotential plane-wave formalism. This rigorous first-principles treatment of electronic structure is computationally expensive and limits the size of tractable systems to a few hundred atoms on most currently available parallel computers. Developed specifically for large parallel systems at LLNL's Center for Applied Scientific Computing, the Qbox implementation of the FPMD method shows unprecedented performance and scaling on BlueGene/L.

  9. Software engineering principles applied to large healthcare information systems--a case report.

    PubMed

    Nardon, Fabiane Bizinella; de A Moura, Lincoln

    2007-01-01

    São Paulo is the largest city in Brazil and one of the largest cities in the world. In 2004, São Paulo City Department of Health decided to implement a Healthcare Information System to support managing healthcare services and provide an ambulatory health record. The resulting information system is one of the largest public healthcare information systems ever built, with more than 2 million lines of code. Although statistics shows that most software projects fail, and the risks for the São Paulo initiative were enormous, the information system was completed on-time and on-budget. In this paper, we discuss the software engineering principles adopted that allowed to accomplish that project's goals, hoping that sharing the experience of this project will help other healthcare information systems initiatives to succeed. PMID:17911673

  10. The guided tissue regeneration principle in endodontic surgery: one-year postoperative results of large periapical lesions.

    PubMed

    Pecora, G; Kim, S; Celletti, R; Davarpanah, M

    1995-01-01

    Twenty patients with large endodontic lesions, which failed to respond to conventional endodontic therapy, were selected for this study. The lesions had a radiographic diameter of at least 10 mm, were removed by periradicular surgery, before retrofilling the apices with either super EBA or dessicated zinc oxide-eugenol. In 10 test sites large e-PTFE membranes (Gortex) were placed to cover the lesions, while at the control sites the lesions were not covered before resuturing. Radio-graphic analysis of the lesions at 3, 6, 9 and 12 months revealed that lesions covered with the membranes healed quicker than the control lesions, and that the quality and quantity of the regenerated bone was superior when membranes were used. Results of the study indicate that guided tissue regeneration (GTR) principles can be effectively applied to the healing of large periapical lesions, especially in through-and-through lesions. PMID:7642328

  11. Large piezoelectric response of quarternary wurtzite nitride alloys and its physical origin from first principles

    NASA Astrophysics Data System (ADS)

    Tholander, C.; Tasnádi, F.; Abrikosov, I. A.; Hultman, L.; Birch, J.; Alling, B.

    2015-11-01

    The potential of quarternary wurtzite TMx /2Mx /2Al1 -xN (TM =Ti , Zr, Hf; M =Mg , Ca, Zn) alloys for piezoelectric applications is investigated using first-principles calculations. All considered alloys show increased piezoelectric response compared to pure AlN, and competing with the best ternary system proven to date: ScAlN. (Zr,Hf)x /2(Mg,Ca)x /2Al1 -xN alloys are particularly promising. Calculations reveal positive mixing enthalpies indicative for phase separating systems; their values are smaller compared to related nitride alloys, which still can be grown as metastable thin films. The wurtzite phase of the alloys is lowest in energy at least up to x =0.5 and for Tix /2Znx /2Al1 -xN in the full composition range. Moreover, calculations reveal that wurtzite TM0.5Zn0.5N (TM =Ti , Zr, Hf) are piezoelectric alloys with d33 ,f=19.95 , 29.89, and 24.65 pC/N respectively, up to six times that of AlN. Finally, we discuss the physical origin behind the increased piezoelectric response and show that the energy difference between tetrahedrally coordinated zinc-blende (B3) and the layered hexagonal (Bk) phases of the TM0.5M0.5N alloy can be used as a descriptor in a high-throughput search for complex wurtzite alloys with high piezoelectric response.

  12. BrainModes: a principled approach to modeling and measuring large-scale neuronal activity.

    PubMed

    Breakspear, Michael J; Daffertshofer, Andreas; Ritter, Petra

    2009-09-30

    Complex systems, such as the brain, exhibit multiple levels of organization due to processes which support the separation of scales across time and/or space. That is, cooperative phenomena--or "modes" of activity--occurring at one scale give rise to coherent spatiotemporal structures at a coarser scale. In turn, structures at the coarser scale constrain--and hence influence--emerging activity at a finer scale. BrainModes is an annual scientific summit which seeks to bring together experimental, computational and theoretical neuroscientists engaged at different levels of organization, with the goal of advancing a principled approach to understanding brain function based on the concept of cooperative phenomena in complex systems. Phenomena of particular interest include synchronization, stochastic influences, and spatiotemporal processes in both healthy and pathological states such as seizures. This Special Issue reports the 2008 BrainModes Workshop, held in Amsterdam (December 2008) which focused on the application of this framework to the analysis of brain oscillations and synchronization phenomena across time scales. PMID:19607859

  13. Modeling optical properties of silicon clusters by first principles: From a few atoms to large nanocrystals

    SciTech Connect

    Nurbawono, Argo; Liu, Shuanglong; Zhang, Chun

    2015-04-21

    Time dependent density functional tight binding (TDDFTB) method is implemented with sparse matrix techniques and improved parallelization algorithms. The method is employed to calculate the optical properties of various Si nanocrystals (NCs). The calculated light absorption spectra of small Si NCs from TDDFTB were found to be comparable with many body perturbation methods utilizing planewave basis sets. For large Si NCs (more than a thousand atoms) that are beyond the reach of conventional approaches, the TDDFTB method is able to produce reasonable results that are consistent with prior experiments. We also employed the method to study the effects of surface chemistry on the optical properties of large Si NCs. We learned that the optical properties of Si NCs can be manipulated with small molecule passivations such as methyl, hydroxyl, amino, and fluorine. In general, the shifts and profiles in the absorption spectra can be tuned with suitably chosen passivants.

  14. Large-Scale Computations Leading to a First-Principles Approach to Nuclear Structure

    SciTech Connect

    Ormand, W E; Navratil, P

    2003-08-18

    We report on large-scale applications of the ab initio, no-core shell model with the primary goal of achieving an accurate description of nuclear structure from the fundamental inter-nucleon interactions. In particular, we show that realistic two-nucleon interactions are inadequate to describe the low-lying structure of {sup 10}B, and that realistic three-nucleon interactions are essential.

  15. A first principle particle mesh method for solution SAXS of large bio-molecular systems

    NASA Astrophysics Data System (ADS)

    Marchi, Massimo

    2016-07-01

    This paper will show that the solution small angle X-ray scattering (SAXS) intensity of globular and membrane proteins can be efficiently and accurately computed from molecular dynamics trajectories using 3D fast Fourier transforms (FFTs). A suitable particle meshing interpolation, similar to the one used in smooth particle mesh Ewald for electrostatic energies and forces, was combined with a uniform solvent density FFT padding scheme to obtain a convenient SAXS spectral resolution. The CPU time scaling of the method, as a function of system size, is highly favorable and its application to large systems such as solutions of solvated membrane proteins is computationally undemanding. Differently from other approaches, all contributions from the simulation cell are included. This means that the subtraction of the buffer from the solution scattering intensity is straightforward and devoid of artifact due to ad hoc definitions of proximal and distal solvent intensity contributions.

  16. A first principle particle mesh method for solution SAXS of large bio-molecular systems.

    PubMed

    Marchi, Massimo

    2016-07-28

    This paper will show that the solution small angle X-ray scattering (SAXS) intensity of globular and membrane proteins can be efficiently and accurately computed from molecular dynamics trajectories using 3D fast Fourier transforms (FFTs). A suitable particle meshing interpolation, similar to the one used in smooth particle mesh Ewald for electrostatic energies and forces, was combined with a uniform solvent density FFT padding scheme to obtain a convenient SAXS spectral resolution. The CPU time scaling of the method, as a function of system size, is highly favorable and its application to large systems such as solutions of solvated membrane proteins is computationally undemanding. Differently from other approaches, all contributions from the simulation cell are included. This means that the subtraction of the buffer from the solution scattering intensity is straightforward and devoid of artifact due to ad hoc definitions of proximal and distal solvent intensity contributions. PMID:27475396

  17. The PubChemQC project: A large chemical database from the first principle calculations

    NASA Astrophysics Data System (ADS)

    Maho, Nakata

    2015-12-01

    In this research, we have been constructing a large database of molecules by ab initio calculations. Currently, we have over 1.53 million entries of 6-31G* B3LYP optimized geometries and ten excited states by 6-31+G* TDDFT calculations. To calculate molecules, we only refer the InChI (International Chemical Identifier) representation of chemical formula by the International Union of Pure and Applied Chemistry (IUPAC), thus, no reference to experimental data. These results are open to public at http://pubchemqc.riken.jp/. The molecular data have been taken from the PubChem Project (http://pubchem.ncbi.nlm.nih.gov/) which is one of the largest in the world (approximately 63 million molecules are listed) and free (public domain) database. Our final goal is, using these data, to develop a molecular search engine or molecular expert system to find molecules which have desired properties.

  18. First principles study of lattice thermal conductivity and large isotope effect in materials

    NASA Astrophysics Data System (ADS)

    Broido, David; Lindsay, Lucas; Reinecke, Tom

    2014-03-01

    The isotope effect--the percent enhancement to a material's lattice thermal conductivity, k, with isotopic purification--depends on the interplay between phonon-isotope and phonon-phonon scattering. Diamond is known to have the largest measured room temperature (RT) isotope effect of any bulk crystal, achieving a k enhancement of 50%. Using an ab initioBoltzmann transport equation approach, we have identified several other materials with far larger RT isotope effects. In particular, we find that germanium carbide (GeC) and beryllium selenide (BeSe) have RT isotope effects of 450%, almost an order of magnitude higher than that in diamond. Isotopic purification in these materials gives surprisingly high intrinsic RT k values, over 1500 Wm-1K-1 for GeC and over 600 Wm-1 K-1 for BeSe, well above those of the best metals. These large values stem from fundamental material properties that give both enhanced phonon scattering by isotopes and weak anharmonic phonon-phonon scattering. The physical insights discussed in this work provide guidance for efficient manipulation of thermal transport properties of compound semiconductors through isotopic modification. This work was supported by ONR, DARPA and NSF.

  19. Computer generation of random deviates.

    PubMed

    Cormack, J; Shuter, B

    1991-06-01

    The need for random deviates arises in many scientific applications, such as the simulation of physical processes, numerical evaluation of complex mathematical formulae and the modeling of decision processes. In medical physics, Monte Carlo simulations have been used in radiology, radiation therapy and nuclear medicine. Specific instances include the modelling of x-ray scattering processes and the addition of random noise to images or curves in order to assess the effects of various processing procedures. Reliable sources of random deviates with statistical properties indistinguishable from true random deviates are a fundamental necessity for such tasks. This paper provides a review of computer algorithms which can be used to generate uniform random deviates and other distributions of interest to medical physicists, along with a few caveats relating to various problems and pitfalls which can occur. Source code listings for the generators discussed (in FORTRAN, Turbo-PASCAL and Data General ASSEMBLER) are available on request from the authors. PMID:1747086

  20. Electronic stopping in liquid water from first principles: An application of large-scale real-time TDDFT simulations

    NASA Astrophysics Data System (ADS)

    Reeves, Kyle; Yao, Yi; Kanai, Yosuke

    Electronic stopping describes the transfer of energy from a highly-energetic charged particle to electrons in a material. This process induces massive electronic excitations via interaction between the material and the highly localized electric field from the charged particle. Understanding this phenomenon in condensed matter systems under proton irradiation has implications in various modern technologies. First-principles simulations, based on our recently-developed large-scale real-time time-dependent density functional theory approach, provide a detailed description of how electrons are excited via a non-equilibrium energy transfer from protons on the attosecond time scale. We apply this computational approach to the important case of liquid water under proton irradiation. Our work reveals several key features of the excitation dynamics at the mesoscopic and molecular levels which support a clearer understanding of the water radiolysis mechanism under proton irradiation. Importantly, we will demonstrate a first-principles determination of the energy transfer rate, (i.e. electronic stopping power) in liquid water, and a comparison to existing empirical models will be presented. We will conclude by discussing how the exchange-correlation approximation influences the calculation of the electronic stopping power.

  1. Real-space method for first-principles electron transport calculations: Self-energy terms of electrodes for large systems

    NASA Astrophysics Data System (ADS)

    Ono, Tomoya; Tsukamoto, Shigeru

    2016-01-01

    We present a fast and stable numerical technique to obtain the self-energy terms of electrodes for first-principles electron transport calculations. Although first-principles calculations based on the real-space finite-difference method are advantageous for execution on massively parallel computers, large-scale transport calculations are hampered by the computational cost and numerical instability of the computation of the self-energy terms. Using the orthogonal complement vectors of the space spanned by the generalized Bloch waves that actually contribute to transport phenomena, the computational accuracy of transport properties is significantly improved with a moderate computational cost. To demonstrate the efficiency of the present technique, the electron transport properties of a Stone-Wales (SW) defect in graphene and silicene are examined. The resonance scattering of the SW defect is observed in the conductance spectrum of silicene since the σ* state of silicene lies near the Fermi energy. In addition, we found that one conduction channel is sensitive to a defect near the Fermi energy, while the other channel is hardly affected. This characteristic behavior of the conduction channels is interpreted in terms of the bonding network between the bilattices of the honeycomb structure in the formation of the SW defect. The present technique enables us to distinguish the different behaviors of the two conduction channels in graphene and silicene owing to its excellent accuracy.

  2. Systematic, spatial imaging of large multimolecular assemblies and the emerging principles of supramolecular order in biological systems

    PubMed Central

    Schubert, Walter

    2013-01-01

    Understanding biological systems at the level of their relational (emergent) molecular properties in functional protein networks relies on imaging methods, able to spatially resolve a tissue or a cell as a giant, non-random, topologically defined collection of interacting supermolecules executing myriads of subcellular mechanisms. Here, the development and findings of parameter-unlimited functional super-resolution microscopy are described—a technology based on the fluorescence imaging cycler (IC) principle capable of co-mapping thousands of distinct biomolecular assemblies at high spatial resolution and differentiation (<40 nm distances). It is shown that the subcellular and transcellular features of such supermolecules can be described at the compositional and constitutional levels; that the spatial connection, relational stoichiometry, and topology of supermolecules generate hitherto unrecognized functional self-segmentation of biological tissues; that hierarchical features, common to thousands of simultaneously imaged supermolecules, can be identified; and how the resulting supramolecular order relates to spatial coding of cellular functionalities in biological systems. A large body of observations with IC molecular systems microscopy collected over 20 years have disclosed principles governed by a law of supramolecular segregation of cellular functionalities. This pervades phenomena, such as exceptional orderliness, functional selectivity, combinatorial and spatial periodicity, and hierarchical organization of large molecular systems, across all species investigated so far. This insight is based on the high degree of specificity, selectivity, and sensitivity of molecular recognition processes for fluorescence imaging beyond the spectral resolution limit, using probe libraries controlled by ICs. © 2013 The Authors. Journal of Molecular Recognition published by John Wiley & Sons, Ltd. PMID:24375580

  3. 48 CFR 2001.404 - Class deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... REGULATORY COMMISSION ACQUISITION REGULATION SYSTEM Deviations From the FAR and the NRCAR 2001.404 Class deviations. Class deviations affect more than one contracting action. Where deviations from the FAR or...

  4. Standard Deviation for Small Samples

    ERIC Educational Resources Information Center

    Joarder, Anwar H.; Latif, Raja M.

    2006-01-01

    Neater representations for variance are given for small sample sizes, especially for 3 and 4. With these representations, variance can be calculated without a calculator if sample sizes are small and observations are integers, and an upper bound for the standard deviation is immediate. Accessible proofs of lower and upper bounds are presented for…

  5. Charge compensation in extremely large magnetoresistance materials LaSb and LaBi revealed by first-principles calculations

    NASA Astrophysics Data System (ADS)

    Guo, Peng-Jie; Yang, Huan-Cheng; Zhang, Bing-Jing; Liu, Kai; Lu, Zhong-Yi

    2016-06-01

    By the first-principles electronic structure calculations, we have systematically studied the electronic structures of recently discovered extremely large magnetoresistance (XMR) materials LaSb and LaBi. We find that both LaSb and LaBi are semimetals with the electron and hole carriers in balance. The calculated carrier densities on the order of 1020cm-3 are in good agreement with the experimental values, implying long mean-free time of carriers at low temperatures and thus high carrier mobilities. With a semiclassical two-band model, the charge compensation and high carrier mobilities naturally explain: (i) the XMR observed in LaSb and LaBi, (ii) the nonsaturating quadratic dependence of XMR on an external magnetic field, and (iii) the resistivity plateau in the turn-on temperature behavior at very low temperatures. The explanation of these features without resorting to the topological effect indicates that they should be the common characteristics of all electron-hole compensated semimetals.

  6. Adsorption and diffusion of Ru adatoms on Ru(0001)-supported graphene: Large-scale first-principles calculations

    DOE PAGESBeta

    Han, Yong; Evans, James W.

    2015-10-27

    Large-scale first-principles density functional theory calculations are performed to investigate the adsorption and diffusion of Ru adatoms on monolayer graphene (G) supported on Ru(0001). The G sheet exhibits a periodic moiré-cell superstructure due to lattice mismatch. Within a moiré cell, there are three distinct regions: fcc, hcp, and mound, in which the C6-ring center is above a fcc site, a hcp site, and a surface Ru atom of Ru(0001), respectively. The adsorption energy of a Ru adatom is evaluated at specific sites in these distinct regions. We find the strongest binding at an adsorption site above a C atom inmore » the fcc region, next strongest in the hcp region, then the fcc-hcp boundary (ridge) between these regions, and the weakest binding in the mound region. Behavior is similar to that observed from small-unit-cell calculations of Habenicht et al. [Top. Catal. 57, 69 (2014)], which differ from previous large-scale calculations. We determine the minimum-energy path for local diffusion near the center of the fcc region and obtain a local diffusion barrier of ~0.48 eV. We also estimate a significantly lower local diffusion barrier in the ridge region. These barriers and information on the adsorption energy variation facilitate development of a realistic model for the global potential energy surface for Ru adatoms. Furthermore, this in turn enables simulation studies elucidating diffusion-mediated directed-assembly of Ru nanoclusters during deposition of Ru on G/Ru(0001).« less

  7. Adsorption and diffusion of Ru adatoms on Ru(0001)-supported graphene: Large-scale first-principles calculations

    SciTech Connect

    Han, Yong; Evans, James W.

    2015-10-27

    Large-scale first-principles density functional theory calculations are performed to investigate the adsorption and diffusion of Ru adatoms on monolayer graphene (G) supported on Ru(0001). The G sheet exhibits a periodic moiré-cell superstructure due to lattice mismatch. Within a moiré cell, there are three distinct regions: fcc, hcp, and mound, in which the C6-ring center is above a fcc site, a hcp site, and a surface Ru atom of Ru(0001), respectively. The adsorption energy of a Ru adatom is evaluated at specific sites in these distinct regions. We find the strongest binding at an adsorption site above a C atom in the fcc region, next strongest in the hcp region, then the fcc-hcp boundary (ridge) between these regions, and the weakest binding in the mound region. Behavior is similar to that observed from small-unit-cell calculations of Habenicht et al. [Top. Catal. 57, 69 (2014)], which differ from previous large-scale calculations. We determine the minimum-energy path for local diffusion near the center of the fcc region and obtain a local diffusion barrier of ~0.48 eV. We also estimate a significantly lower local diffusion barrier in the ridge region. These barriers and information on the adsorption energy variation facilitate development of a realistic model for the global potential energy surface for Ru adatoms. Furthermore, this in turn enables simulation studies elucidating diffusion-mediated directed-assembly of Ru nanoclusters during deposition of Ru on G/Ru(0001).

  8. Adsorption and diffusion of Ru adatoms on Ru(0001)-supported graphene: Large-scale first-principles calculations

    SciTech Connect

    Han, Yong; Evans, James W.

    2015-10-28

    Large-scale first-principles density functional theory calculations are performed to investigate the adsorption and diffusion of Ru adatoms on monolayer graphene (G) supported on Ru(0001). The G sheet exhibits a periodic moiré-cell superstructure due to lattice mismatch. Within a moiré cell, there are three distinct regions: fcc, hcp, and mound, in which the C{sub 6}-ring center is above a fcc site, a hcp site, and a surface Ru atom of Ru(0001), respectively. The adsorption energy of a Ru adatom is evaluated at specific sites in these distinct regions. We find the strongest binding at an adsorption site above a C atom in the fcc region, next strongest in the hcp region, then the fcc-hcp boundary (ridge) between these regions, and the weakest binding in the mound region. Behavior is similar to that observed from small-unit-cell calculations of Habenicht et al. [Top. Catal. 57, 69 (2014)], which differ from previous large-scale calculations. We determine the minimum-energy path for local diffusion near the center of the fcc region and obtain a local diffusion barrier of ∼0.48 eV. We also estimate a significantly lower local diffusion barrier in the ridge region. These barriers and information on the adsorption energy variation facilitate development of a realistic model for the global potential energy surface for Ru adatoms. This in turn enables simulation studies elucidating diffusion-mediated directed-assembly of Ru nanoclusters during deposition of Ru on G/Ru(0001)

  9. Perception of aircraft Deviation Cues

    NASA Technical Reports Server (NTRS)

    Martin, Lynne; Azuma, Ronald; Fox, Jason; Verma, Savita; Lozito, Sandra

    2005-01-01

    To begin to address the need for new displays, required by a future airspace concept to support new roles that will be assigned to flight crews, a study of potentially informative display cues was undertaken. Two cues were tested on a simple plan display - aircraft trajectory and flight corridor. Of particular interest was the speed and accuracy with which participants could detect an aircraft deviating outside its flight corridor. Presence of the trajectory cue significantly reduced participant reaction time to a deviation while the flight corridor cue did not. Although non-significant, the flight corridor cue seemed to have a relationship with the accuracy of participants judgments rather than their speed. As this is the second of a series of studies, these issues will be addressed further in future studies.

  10. 48 CFR 1301.403 - Individual deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DEPARTMENT OF COMMERCE ACQUISITION REGULATIONS SYSTEM Deviations From the FAR 1301.403 Individual deviations. The designee authorized to approve individual deviations from the FAR is set forth in CAM 1301.70....

  11. 48 CFR 1401.403 - Individual deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DEPARTMENT OF THE INTERIOR ACQUISITION REGULATION SYSTEM Deviations from the FAR and DIAR 1401.403 Individual deviations. (a) The Director, PAM, is authorized to approve deviations of FAR provisions (see FAR 1.4)...

  12. 48 CFR 2001.403 - Individual deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... NUCLEAR REGULATORY COMMISSION ACQUISITION REGULATION SYSTEM Deviations From the FAR and the NRCAR 2001.403 Individual deviations. In individual cases, deviations from either the FAR or the NRCAR will be...

  13. 48 CFR 301.403 - Individual deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION REGULATION SYSTEM Deviations From the FAR 301.403 Individual deviations. Contracting activities shall prepare requests for individual deviations to either the FAR or HHSAR in accordance with 301.470....

  14. 48 CFR 2801.404 - Class deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... JUSTICE ACQUISITION REGULATIONS SYSTEM Deviations From the FAR and JAR 2801.404 Class deviations. Requests for class deviations from the FAR or the JAR shall be submitted to the PE. The PE will consult...

  15. 48 CFR 401.404 - Class deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION REGULATION SYSTEM Deviations From the FAR and AGAR 401.404 Class deviations. Where deviations from the FAR or AGAR are considered necessary for classes of contracts, requests for authority to...

  16. 48 CFR 401.404 - Class deviations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ACQUISITION REGULATION SYSTEM Deviations From the FAR and AGAR 401.404 Class deviations. Where deviations from the FAR or AGAR are considered necessary for classes of contracts, requests for authority to...

  17. Large Neutral Amino Acid Supplementation Exerts Its Effect through Three Synergistic Mechanisms: Proof of Principle in Phenylketonuria Mice

    PubMed Central

    van Vliet, Danique; Bruinenberg, Vibeke M.; Mazzola, Priscila N.; van Faassen, Martijn H. J. R.; de Blaauw, Pim; Kema, Ido P.; Heiner-Fokkema, M. Rebecca; van Anholt, Rogier D.; van der Zee, Eddy A.; van Spronsen, Francjan J.

    2015-01-01

    Background Phenylketonuria (PKU) was the first disorder in which severe neurocognitive dysfunction could be prevented by dietary treatment. However, despite this effect, neuropsychological outcome in PKU still remains suboptimal and the phenylalanine-restricted diet is very demanding. To improve neuropsychological outcome and relieve the dietary restrictions for PKU patients, supplementation of large neutral amino acids (LNAA) is suggested as alternative treatment strategy that might correct all brain biochemical disturbances caused by high blood phenylalanine, and thereby improve neurocognitive functioning. Objective As a proof-of-principle, this study aimed to investigate all hypothesized biochemical treatment objectives of LNAA supplementation (normalizing brain phenylalanine, non-phenylalanine LNAA, and monoaminergic neurotransmitter concentrations) in PKU mice. Methods C57Bl/6 Pah-enu2 (PKU) mice and wild-type mice received a LNAA supplemented diet, an isonitrogenic/isocaloric high-protein control diet, or normal chow. After six weeks of dietary treatment, blood and brain amino acid and monoaminergic neurotransmitter concentrations were assessed. Results In PKU mice, the investigated LNAA supplementation regimen significantly reduced blood and brain phenylalanine concentrations by 33% and 26%, respectively, compared to normal chow (p<0.01), while alleviating brain deficiencies of some but not all supplemented LNAA. Moreover, LNAA supplementation in PKU mice significantly increased brain serotonin and norepinephrine concentrations from 35% to 71% and from 57% to 86% of wild-type concentrations (p<0.01), respectively, but not brain dopamine concentrations (p = 0.307). Conclusions This study shows that LNAA supplementation without dietary phenylalanine restriction in PKU mice improves brain biochemistry through all three hypothesized biochemical mechanisms. Thereby, these data provide proof-of-concept for LNAA supplementation as a valuable alternative dietary

  18. 48 CFR 1401.404 - Class deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... THE INTERIOR ACQUISITION REGULATION SYSTEM Deviations from the FAR and DIAR 1401.404 Class deviations. (a) The Director, PAM, is authorized to approve class deviations of FAR or DIAR provisions which... actions which will be affected. (c) For a FAR class deviation the Director, PAM, shall consult with...

  19. 48 CFR 1.404 - Class deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION REGULATIONS SYSTEM Deviations from the FAR 1.404 Class deviations. Class deviations affect more... basis, it should propose a FAR revision, if appropriate. Civilian agencies, other than NASA, must furnish a copy of each approved class deviation to the FAR Secretariat. (a) For civilian agencies...

  20. 48 CFR 801.404 - Class deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Deviations from the FAR or VAAR 801.404 Class deviations. Authority to authorize class deviations from the FAR and VAAR is delegated to the SPE and is further delegated to the DSPE. The DSPE may authorize class deviations from the FAR and VAAR when a...

  1. 48 CFR 801.403 - Individual deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DEPARTMENT OF VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Deviations from the FAR or VAAR 801.403 Individual deviations. (a) Authority to authorize individual deviations from the FAR and VAAR is delegated to... deviate from the policies in the FAR or VAAR, the contracting officer, in accordance with...

  2. 14 CFR 125.3 - Deviation authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Deviation authority. 125.3 Section 125.3... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT General § 125.3 Deviation authority. (a... justification for the deviation requested. (d) After February 2, 2012, no deviation authority from the...

  3. 14 CFR 125.3 - Deviation authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Deviation authority. 125.3 Section 125.3... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT General § 125.3 Deviation authority. (a... justification for the deviation requested. (d) After February 2, 2012, no deviation authority from the...

  4. 14 CFR 125.3 - Deviation authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Deviation authority. 125.3 Section 125.3... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT General § 125.3 Deviation authority. (a... justification for the deviation requested. (d) After February 2, 2012, no deviation authority from the...

  5. 48 CFR 2501.404 - Class deviations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Class deviations. 2501.404 Section 2501.404 Federal Acquisition Regulations System NATIONAL SCIENCE FOUNDATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations From the FAR 2501.404 Class deviations. Class deviations may...

  6. 10 CFR 602.4 - Deviations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... proposed deviation from this part would be a deviation from 10 CFR part 600, the deviation must also be... 10 Energy 4 2014-01-01 2014-01-01 false Deviations. 602.4 Section 602.4 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL...

  7. 10 CFR 602.4 - Deviations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... proposed deviation from this part would be a deviation from 10 CFR part 600, the deviation must also be... 10 Energy 4 2013-01-01 2013-01-01 false Deviations. 602.4 Section 602.4 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL...

  8. 10 CFR 602.4 - Deviations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... proposed deviation from this part would be a deviation from 10 CFR part 600, the deviation must also be... 10 Energy 4 2010-01-01 2010-01-01 false Deviations. 602.4 Section 602.4 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL...

  9. 10 CFR 602.4 - Deviations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... proposed deviation from this part would be a deviation from 10 CFR part 600, the deviation must also be... 10 Energy 4 2012-01-01 2012-01-01 false Deviations. 602.4 Section 602.4 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL...

  10. 10 CFR 602.4 - Deviations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... proposed deviation from this part would be a deviation from 10 CFR part 600, the deviation must also be... 10 Energy 4 2011-01-01 2011-01-01 false Deviations. 602.4 Section 602.4 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL...

  11. 48 CFR 401.403 - Individual deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... AGRICULTURE ACQUISITION REGULATION SYSTEM Deviations From the FAR and AGAR 401.403 Individual deviations. In individual cases, deviations from either the FAR or the AGAR will be authorized only when essential to effect... AGAR, after coordinating with the General Counsel and the SPE. No deviations from the FAR or AGAR...

  12. 48 CFR 401.403 - Individual deviations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... AGRICULTURE ACQUISITION REGULATION SYSTEM Deviations From the FAR and AGAR 401.403 Individual deviations. In individual cases, deviations from either the FAR or the AGAR will be authorized only when essential to effect... AGAR, after coordinating with the General Counsel and the SPE. No deviations from the FAR or AGAR...

  13. 48 CFR 2501.404 - Class deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Class deviations. 2501.404 Section 2501.404 Federal Acquisition Regulations System NATIONAL SCIENCE FOUNDATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations From the FAR 2501.404 Class deviations. Class deviations may...

  14. 48 CFR 2501.404 - Class deviations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Class deviations. 2501.404 Section 2501.404 Federal Acquisition Regulations System NATIONAL SCIENCE FOUNDATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations From the FAR 2501.404 Class deviations. Class deviations may...

  15. 48 CFR 2501.404 - Class deviations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Class deviations. 2501.404 Section 2501.404 Federal Acquisition Regulations System NATIONAL SCIENCE FOUNDATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations From the FAR 2501.404 Class deviations. Class deviations may...

  16. 48 CFR 1501.403 - Individual deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Individual deviations. 1501.403 Section 1501.403 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL GENERAL Deviations 1501.403 Individual deviations. Requests for individual deviations from the FAR and the EPAAR shall be submitted to the Head...

  17. 48 CFR 1501.404 - Class deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Class deviations. 1501.404 Section 1501.404 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL GENERAL Deviations 1501.404 Class deviations. Requests for class deviations to the FAR and the EPAAR shall be submitted to the HCA for processing...

  18. 48 CFR 1501.404 - Class deviations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Class deviations. 1501.404 Section 1501.404 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL GENERAL Deviations 1501.404 Class deviations. Requests for class deviations to the FAR and the EPAAR shall be submitted to the HCA for processing...

  19. 48 CFR 1501.403 - Individual deviations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Individual deviations. 1501.403 Section 1501.403 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL GENERAL Deviations 1501.403 Individual deviations. Requests for individual deviations from the FAR and the EPAAR shall be submitted to the Head...

  20. 48 CFR 1501.403 - Individual deviations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Individual deviations. 1501.403 Section 1501.403 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL GENERAL Deviations 1501.403 Individual deviations. Requests for individual deviations from the FAR and the EPAAR shall be submitted to the Head...

  1. 48 CFR 1501.404 - Class deviations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Class deviations. 1501.404 Section 1501.404 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL GENERAL Deviations 1501.404 Class deviations. Requests for class deviations to the FAR and the EPAAR shall be submitted to the HCA for processing...

  2. Assessment and classification of protocol deviations

    PubMed Central

    Ghooi, Ravindra Bhaskar; Bhosale, Neelambari; Wadhwani, Reena; Divate, Pathik; Divate, Uma

    2016-01-01

    Introduction: Deviations from the approved trial protocol are common during clinical trials. They have been conventionally classified as deviations or violations, depending on their impact on the trial. Methods: A new method has been proposed by which deviations are classified in five grades from 1 to 5. A deviation of Grade 1 has no impact on the subjects’ well-being or on the quality of data. At the maximum, a deviation Grade 5 leads to the death of the subject. This method of classification was applied to deviations noted in the center over the last 3 years. Results: It was observed that most deviations were of Grades 1 and 2, with fewer falling in Grades 3 and 4. There were no deviations that led to the death of the subject (Grade 5). Discussion: This method of classification would help trial managers decide on the action to be taken on the occurrence of deviations, which would be based on their impact. PMID:27453830

  3. Allan deviation analysis of financial return series

    NASA Astrophysics Data System (ADS)

    Hernández-Pérez, R.

    2012-05-01

    We perform a scaling analysis for the return series of different financial assets applying the Allan deviation (ADEV), which is used in the time and frequency metrology to characterize quantitatively the stability of frequency standards since it has demonstrated to be a robust quantity to analyze fluctuations of non-stationary time series for different observation intervals. The data used are opening price daily series for assets from different markets during a time span of around ten years. We found that the ADEV results for the return series at short scales resemble those expected for an uncorrelated series, consistent with the efficient market hypothesis. On the other hand, the ADEV results for absolute return series for short scales (first one or two decades) decrease following approximately a scaling relation up to a point that is different for almost each asset, after which the ADEV deviates from scaling, which suggests that the presence of clustering, long-range dependence and non-stationarity signatures in the series drive the results for large observation intervals.

  4. Large-scale first principles and tight-binding density functional theory calculations on hydrogen-passivated silicon nanorods

    NASA Astrophysics Data System (ADS)

    Zonias, Nicholas; Lagoudakis, Pavlos; Skylaris, Chris-Kriton

    2010-01-01

    We present a computational study by density functional theory (DFT) of entire silicon nanorods with up to 1648 atoms without any periodicity or symmetry imposed. The nanorods have been selected to have varying aspect ratios and levels of surface passivation with hydrogen. The structures of the nanorods have been optimized using a density functional tight-binding approach, while energies and electronic properties have been computed using linear-scaling DFT with plane-wave accuracy with the ONETEP (Skylaris et al 2005 J. Chem. Phys. 122 084119) program. The aspect ratio and surface passivation (1 × 1 and 2 × 1 reconstructions) along with the size of the nanorods which leads to quantum confinement along all three dimensions, significantly affect their electronic properties. The structures of the nanorods also show interesting behaviour as, depending on their characteristics, they can in certain areas retain the structure of bulk silicon while in other parts significantly deviate from it.

  5. 48 CFR 501.403 - Individual deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... GENERAL SERVICES ADMINISTRATION ACQUISITION REGULATION SYSTEM Deviations From the FAR and GSAR 501.403... Contracting Activity (HCA) must approve an individual deviation to the FAR. The authority to grant...

  6. 14 CFR 139.113 - Deviations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... life or property, the certificate holder may deviate from any requirement of subpart D of this part, or..., notify the Regional Airports Division Manager of the nature, extent, and duration of the deviation....

  7. 48 CFR 1.403 - Individual deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Individual deviations. 1.403 Section 1.403 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations from the FAR 1.403 Individual deviations....

  8. 48 CFR 501.404 - Class deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SERVICES ADMINISTRATION ACQUISITION REGULATION SYSTEM Deviations From the FAR and GSAR 501.404 Class... an individual contract action. (1) A class deviation to the FAR must be forwarded by the cognizant HCA to GSA's SPE for approval. Prior to approving a class deviation to the FAR, the SPE will...

  9. 48 CFR 1201.404 - Class deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION REGULATIONS SYSTEM 70-Deviations From the FAR and TAR 1201.404 Class deviations. The SPE may grant in writing class deviations from the (FAR) 48 CFR chapter 1 and (TAR) 48 CFR chapter 12, unless (FAR) 48 CFR 1.405(e) applies....

  10. 48 CFR 1901.403 - Individual deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... THE BROADCASTING BOARD OF GOVERNORS ACQUISITION REGULATION SYSTEM Deviations From the FAR 1901.403 Individual deviations. Deviations from the IAAR or the FAR in individual cases shall be authorized by the Board Procurement Executive or a designee unless FAR 1.405(e) is applicable. The request shall cite...

  11. 10 CFR 961.4 - Deviations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Deviations. 961.4 Section 961.4 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE General § 961.4 Deviations. Requests for authority to deviate from this part shall be submitted in writing...

  12. 10 CFR 961.4 - Deviations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Deviations. 961.4 Section 961.4 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE General § 961.4 Deviations. Requests for authority to deviate from this part shall be submitted in writing...

  13. 10 CFR 961.4 - Deviations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Deviations. 961.4 Section 961.4 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE General § 961.4 Deviations. Requests for authority to deviate from this part shall be submitted in writing...

  14. 48 CFR 301.403 - Individual deviations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Individual deviations. 301.403 Section 301.403 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Deviations From the FAR 301.403 Individual deviations. Contracting...

  15. 48 CFR 301.404 - Class deviations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Class deviations. 301.404 Section 301.404 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Deviations From the FAR 301.404 Class deviations. Contracting activities shall...

  16. 48 CFR 301.403 - Individual deviations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Individual deviations. 301.403 Section 301.403 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Deviations From the FAR 301.403 Individual deviations. Contracting...

  17. 48 CFR 301.404 - Class deviations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Class deviations. 301.404 Section 301.404 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Deviations From the FAR 301.404 Class deviations. Contracting activities shall...

  18. Introducing the Mean Absolute Deviation "Effect" Size

    ERIC Educational Resources Information Center

    Gorard, Stephen

    2015-01-01

    This paper revisits the use of effect sizes in the analysis of experimental and similar results, and reminds readers of the relative advantages of the mean absolute deviation as a measure of variation, as opposed to the more complex standard deviation. The mean absolute deviation is easier to use and understand, and more tolerant of extreme…

  19. 48 CFR 2501.403 - Individual deviations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Individual deviations. 2501.403 Section 2501.403 Federal Acquisition Regulations System NATIONAL SCIENCE FOUNDATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations From the FAR 2501.403 Individual deviations....

  20. 10 CFR 961.4 - Deviations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the deviation and nuclear power reactor(s) affected; (e) A statement as to whether the deviation has... 10 Energy 4 2011-01-01 2011-01-01 false Deviations. 961.4 Section 961.4 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE...

  1. 48 CFR 2501.403 - Individual deviations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Individual deviations. 2501.403 Section 2501.403 Federal Acquisition Regulations System NATIONAL SCIENCE FOUNDATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations From the FAR 2501.403 Individual deviations....

  2. 48 CFR 2501.403 - Individual deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Individual deviations. 2501.403 Section 2501.403 Federal Acquisition Regulations System NATIONAL SCIENCE FOUNDATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations From the FAR 2501.403 Individual deviations....

  3. 48 CFR 2501.403 - Individual deviations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Individual deviations. 2501.403 Section 2501.403 Federal Acquisition Regulations System NATIONAL SCIENCE FOUNDATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations From the FAR 2501.403 Individual deviations....

  4. The Standard Deviation of Launch Vehicle Environments

    NASA Technical Reports Server (NTRS)

    Yunis, Isam

    2005-01-01

    Statistical analysis is used in the development of the launch vehicle environments of acoustics, vibrations, and shock. The standard deviation of these environments is critical to accurate statistical extrema. However, often very little data exists to define the standard deviation and it is better to use a typical standard deviation than one derived from a few measurements. This paper uses Space Shuttle and expendable launch vehicle flight data to define a typical standard deviation for acoustics and vibrations. The results suggest that 3dB is a conservative and reasonable standard deviation for the source environment and the payload environment.

  5. Structure of deviations from optimality in biological systems

    PubMed Central

    Pérez-Escudero, Alfonso; Rivera-Alba, Marta; de Polavieja, Gonzalo G.

    2009-01-01

    Optimization theory has been used to analyze evolutionary adaptation. This theory has explained many features of biological systems, from the genetic code to animal behavior. However, these systems show important deviations from optimality. Typically, these deviations are large in some particular components of the system, whereas others seem to be almost optimal. Deviations from optimality may be due to many factors in evolution, including stochastic effects and finite time, that may not allow the system to reach the ideal optimum. However, we still expect the system to have a higher probability of reaching a state with a higher value of the proposed indirect measure of fitness. In systems of many components, this implies that the largest deviations are expected in those components with less impact on the indirect measure of fitness. Here, we show that this simple probabilistic rule explains deviations from optimality in two very different biological systems. In Caenorhabditis elegans, this rule successfully explains the experimental deviations of the position of neurons from the configuration of minimal wiring cost. In Escherichia coli, the probabilistic rule correctly obtains the structure of the experimental deviations of metabolic fluxes from the configuration that maximizes biomass production. This approach is proposed to explain or predict more data than optimization theory while using no extra parameters. Thus, it can also be used to find and refine hypotheses about which constraints have shaped biological structures in evolution. PMID:19918070

  6. First-principles studies on vacancy-modified interstitial diffusion mechanism of oxygen in nickel, associated with large-scale atomic simulation techniques

    SciTech Connect

    Fang, H. Z.; Shang, S. L.; Wang, Y.; Liu, Z. K.; Alfonso, D.; Alman, D. E.; Shin, Y. K.; Zou, C. Y.; Duin, A. C. T. van; Lei, Y. K.; Wang, G. F.

    2014-01-28

    This paper is concerned with the prediction of oxygen diffusivities in fcc nickel from first-principles calculations and large-scale atomic simulations. Considering only the interstitial octahedral to tetrahedral to octahedral minimum energy pathway for oxygen diffusion in fcc lattice, greatly underestimates the migration barrier and overestimates the diffusivities by several orders of magnitude. The results indicate that vacancies in the Ni-lattice significantly impact the migration barrier of oxygen in nickel. Incorporation of the effect of vacancies results in predicted diffusivities consistent with available experimental data. First-principles calculations show that at high temperatures the vacancy concentration is comparable to the oxygen solubility, and there is a strong binding energy and a redistribution of charge density between the oxygen atom and vacancy. Consequently, there is a strong attraction between the oxygen and vacancy in the Ni lattice, which impacts diffusion.

  7. Accurate and Scalable O(N) Algorithm for First-Principles Molecular-Dynamics Computations on Large Parallel Computers

    NASA Astrophysics Data System (ADS)

    Osei-Kuffuor, Daniel; Fattebert, Jean-Luc

    2014-01-01

    We present the first truly scalable first-principles molecular dynamics algorithm with O(N) complexity and controllable accuracy, capable of simulating systems with finite band gaps of sizes that were previously impossible with this degree of accuracy. By avoiding global communications, we provide a practical computational scheme capable of extreme scalability. Accuracy is controlled by the mesh spacing of the finite difference discretization, the size of the localization regions in which the electronic wave functions are confined, and a cutoff beyond which the components of the overlap matrix can be omitted when computing selected elements of its inverse. We demonstrate the algorithm's excellent parallel scaling for up to 101 952 atoms on 23 328 processors, with a wall-clock time of the order of 1 min per molecular dynamics time step and numerical error on the forces of less than 7×10-4 Ha/Bohr.

  8. Accurate and Scalable O(N) Algorithm for First-Principles Molecular-Dynamics Computations on Large Parallel Computers

    SciTech Connect

    Osei-Kuffuor, Daniel; Fattebert, Jean-Luc

    2014-01-01

    We present the first truly scalable first-principles molecular dynamics algorithm with O(N) complexity and controllable accuracy, capable of simulating systems with finite band gaps of sizes that were previously impossible with this degree of accuracy. By avoiding global communications, we provide a practical computational scheme capable of extreme scalability. Accuracy is controlled by the mesh spacing of the finite difference discretization, the size of the localization regions in which the electronic wave functions are confined, and a cutoff beyond which the components of the overlap matrix can be omitted when computing selected elements of its inverse. We demonstrate the algorithm's excellent parallel scaling for up to 101 952 atoms on 23 328 processors, with a wall-clock time of the order of 1 min per molecular dynamics time step and numerical error on the forces of less than 7x10-4 Ha/Bohr.

  9. Phonon-isotope scattering and thermal conductivity in materials with a large isotope effect: A first-principles study

    NASA Astrophysics Data System (ADS)

    Lindsay, L.; Broido, D. A.; Reinecke, T. L.

    2013-10-01

    The interplay between phonon-isotope and phonon-phonon scattering in determining lattice thermal conductivities in semiconductors and insulators is examined using an ab initio Boltzmann transport equation approach. We identify materials with large enhancements to their thermal conductivities with isotopic purification, known as the isotope effect, and we focus in particular on results for beryllium-VI compounds and cubic germanium carbide. We find that germanium carbide and beryllium selenide have very large room temperature isotope effects of 450%, far larger than in any other material. Thus, isotopic purification in these materials gives surprisingly high intrinsic room temperature thermal conductivities, over 1500 Wm-1 K-1 for germanium carbide and over 600 Wm-1 K-1 for beryllium selenide, well above those of the best metals. In compound semiconductors, a large mass ratio of the constituent atoms and large isotope mixture for the heavier atom gives enhanced isotope scattering. A frequency gap between acoustic and optic phonons (also due to a large mass ratio) and bunching of the acoustic phonon branches give weak anharmonic scattering. Combined, weak anharmonic phonon scattering and strong isotope scattering give a large isotope effect in the materials examined here. The physical insights discussed in this work will help guide the efficient manipulation of thermal transport properties of compound semiconductors through isotopic modification.

  10. Nasal Septal Deviation and Facial Skeletal Asymmetries.

    PubMed

    Hartman, Christopher; Holton, Nathan; Miller, Steven; Yokley, Todd; Marshall, Steven; Srinivasan, Sreedevi; Southard, Thomas

    2016-03-01

    During ontogeny, the nasal septum exerts a morphogenetic influence on the surrounding facial skeleton. While the influence of the septum is well established in long snouted animal models, its role in human facial growth is less clear. If the septum is a facial growth center in humans, we would predict that deviated septal growth would be associated with facial skeletal asymmetries. Using computed tomographic (CT) scans of n = 55 adult subjects, the purpose of this study was to test whether there is a correlation between septal deviation and facial asymmetries using three-dimensional (3D) geometric morphometric techniques. We calculated deviation as a percentage of septal volume relative to the volume of a modeled non-deviated septum. We then recorded skeletal landmarks representing the nasal, palatal, and lateral facial regions. Landmark data were superimposed using Procrustes analysis. First, we examined the correlation between nasal septal deviation and the overall magnitude of asymmetry. Next, we assessed whether there was a relationship between nasal septal deviation and more localized aspects of asymmetry using multivariate regression analysis. Our results indicate that while there was no correlation between septal deviation and the overall magnitude of asymmetry, septal deviation was associated with asymmetry primarily in the nasal floor and the palatal region. Septal deviation was unassociated with asymmetries in the lateral facial skeleton. Though we did not test the causal relationship between nasal septal deviation and facial asymmetry, our results suggest that the nasal septum may have an influence on patterns of adult facial form. PMID:26677010

  11. A Scalable O(N) Algorithm for Large-Scale Parallel First-Principles Molecular Dynamics Simulations

    SciTech Connect

    Osei-Kuffuor, Daniel; Fattebert, Jean-Luc

    2014-01-01

    Traditional algorithms for first-principles molecular dynamics (FPMD) simulations only gain a modest capability increase from current petascale computers, due to their O(N3) complexity and their heavy use of global communications. To address this issue, we are developing a truly scalable O(N) complexity FPMD algorithm, based on density functional theory (DFT), which avoids global communications. The computational model uses a general nonorthogonal orbital formulation for the DFT energy functional, which requires knowledge of selected elements of the inverse of the associated overlap matrix. We present a scalable algorithm for approximately computing selected entries of the inverse of the overlap matrix, based on an approximate inverse technique, by inverting local blocks corresponding to principal submatrices of the global overlap matrix. The new FPMD algorithm exploits sparsity and uses nearest neighbor communication to provide a computational scheme capable of extreme scalability. Accuracy is controlled by the mesh spacing of the finite difference discretization, the size of the localization regions in which the electronic orbitals are confined, and a cutoff beyond which the entries of the overlap matrix can be omitted when computing selected entries of its inverse. We demonstrate the algorithm's excellent parallel scaling for up to O(100K) atoms on O(100K) processors, with a wall-clock time of O(1) minute per molecular dynamics time step.

  12. Large deviations of Rouse polymer chain: First passage problem

    NASA Astrophysics Data System (ADS)

    Cao, Jing; Zhu, Jian; Wang, Zuowei; Likhtman, Alexei E.

    2015-11-01

    The purpose of this paper is to investigate several analytical methods of solving first passage (FP) problem for the Rouse model, a simplest model of a polymer chain. We show that this problem has to be treated as a multi-dimensional Kramers' problem, which presents rich and unexpected behavior. We first perform direct and forward-flux sampling (FFS) simulations and measure the mean first-passage time τ(z) for the free end to reach a certain distance z away from the origin. The results show that the mean FP time is getting faster if the Rouse chain is represented by more beads. Two scaling regimes of τ(z) are observed, with transition between them varying as a function of chain length. We use these simulation results to test two theoretical approaches. One is a well known asymptotic theory valid in the limit of zero temperature. We show that this limit corresponds to fully extended chain when each chain segment is stretched, which is not particularly realistic. A new theory based on the well known Freidlin-Wentzell theory is proposed, where dynamics is projected onto the minimal action path. The new theory predicts both scaling regimes correctly, but fails to get the correct numerical prefactor in the first regime. Combining our theory with the FFS simulations leads us to a simple analytical expression valid for all extensions and chain lengths. One of the applications of polymer FP problem occurs in the context of branched polymer rheology. In this paper, we consider the arm-retraction mechanism in the tube model, which maps exactly on the model we have solved. The results are compared to the Milner-McLeish theory without constraint release, which is found to overestimate FP time by a factor of 10 or more.

  13. Large Deviation Statistics of Vorticity Stretching in Isotropic Turbulence

    NASA Astrophysics Data System (ADS)

    Johnson, Perry; Meneveau, Charles

    2015-11-01

    A key feature of 3D fluid turbulence is the stretching/re-alignment of vorticity by the action of the strain-rate. It is shown using the cumulant-generating function that cumulative vorticity stretching along a Lagrangian path in isotropic turbulence behaves statistically like a sum of i.i.d. variables. The Cramer function for vorticity stretching is computed from the JHTDB isotropic DNS (Reλ = 430) and compared to those of the finite-time Lyapunov exponents (FTLE) for material deformation. As expected the mean cumulative vorticity stretching is slightly less than that of the most-stretched material line (largest FTLE), due to the vorticity's preferential alignment with the second-largest eigenvalue of strain-rate and the material line's preferential alignment with the largest eigenvalue. However, the vorticity stretching tends to be significantly larger than the second-largest FTLE, and the Cramer functions reveal that the statistics of vorticity stretching fluctuations are more similar to those of largest FTLE. A model Fokker-Planck equation is constructed by approximating the viscous destruction of vorticity with a deterministic non-linear relaxation law matching conditional statistics, while the fluctuations in vorticity stretching are modelled by stochastic noise matching the statistics encoded in the Cramer function. The model predicts a stretched-exponential tail for the vorticity magnitude PDF, with good agreement for the exponent but significant error (30-40%) in the pre-factor. Supported by NSF Graduate Fellowship (DGE-1232825) and NSF Grant CMMI-0941530.

  14. Large deviations of Rouse polymer chain: First passage problem.

    PubMed

    Cao, Jing; Zhu, Jian; Wang, Zuowei; Likhtman, Alexei E

    2015-11-28

    The purpose of this paper is to investigate several analytical methods of solving first passage (FP) problem for the Rouse model, a simplest model of a polymer chain. We show that this problem has to be treated as a multi-dimensional Kramers' problem, which presents rich and unexpected behavior. We first perform direct and forward-flux sampling (FFS) simulations and measure the mean first-passage time τ(z) for the free end to reach a certain distance z away from the origin. The results show that the mean FP time is getting faster if the Rouse chain is represented by more beads. Two scaling regimes of τ(z) are observed, with transition between them varying as a function of chain length. We use these simulation results to test two theoretical approaches. One is a well known asymptotic theory valid in the limit of zero temperature. We show that this limit corresponds to fully extended chain when each chain segment is stretched, which is not particularly realistic. A new theory based on the well known Freidlin-Wentzell theory is proposed, where dynamics is projected onto the minimal action path. The new theory predicts both scaling regimes correctly, but fails to get the correct numerical prefactor in the first regime. Combining our theory with the FFS simulations leads us to a simple analytical expression valid for all extensions and chain lengths. One of the applications of polymer FP problem occurs in the context of branched polymer rheology. In this paper, we consider the arm-retraction mechanism in the tube model, which maps exactly on the model we have solved. The results are compared to the Milner-McLeish theory without constraint release, which is found to overestimate FP time by a factor of 10 or more. PMID:26627948

  15. 48 CFR 1001.404 - Class deviations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Class deviations. 1001.404 Section 1001.404 Federal Acquisition Regulations System DEPARTMENT OF THE TREASURY GENERAL DEPARTMENT OF THE TREASURY ACQUISITION REGULATION (DTAR) SYSTEM Deviations from the FAR 1001.404 Class...

  16. 48 CFR 1001.403 - Individual deviations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Individual deviations. 1001.403 Section 1001.403 Federal Acquisition Regulations System DEPARTMENT OF THE TREASURY GENERAL DEPARTMENT OF THE TREASURY ACQUISITION REGULATION (DTAR) SYSTEM Deviations from the FAR 1001.403...

  17. 34 CFR 74.4 - Deviations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false Deviations. 74.4 Section 74.4 Education Office of the Secretary, Department of Education ADMINISTRATION OF GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 74.4 Deviations. The Secretary, after consultation with the Office of...

  18. 34 CFR 74.4 - Deviations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Deviations. 74.4 Section 74.4 Education Office of the Secretary, Department of Education ADMINISTRATION OF GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 74.4 Deviations. The Secretary,...

  19. 49 CFR 19.4 - Deviations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Deviations. 19.4 Section 19.4 Transportation Office of the Secretary of Transportation UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 19.4 Deviations. The Office of Management and Budget...

  20. 22 CFR 518.4 - Deviations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Deviations. 518.4 Section 518.4 Foreign Relations BROADCASTING BOARD OF GOVERNORS UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 518.4 Deviations. The Office of Management and Budget...

  1. 22 CFR 518.4 - Deviations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Deviations. 518.4 Section 518.4 Foreign Relations BROADCASTING BOARD OF GOVERNORS UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 518.4 Deviations....

  2. 22 CFR 518.4 - Deviations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Deviations. 518.4 Section 518.4 Foreign Relations BROADCASTING BOARD OF GOVERNORS UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 518.4 Deviations....

  3. 22 CFR 145.4 - Deviations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Deviations. 145.4 Section 145.4 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 145.4 Deviations. The Office of Management...

  4. 22 CFR 145.4 - Deviations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Deviations. 145.4 Section 145.4 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 145.4 Deviations. The Office of Management...

  5. 20 CFR 435.4 - Deviations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Deviations. 435.4 Section 435.4 Employees' Benefits SOCIAL SECURITY ADMINISTRATION UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER NON-PROFIT ORGANIZATIONS, AND COMMERCIAL ORGANIZATIONS General § 435.4 Deviations. The...

  6. 22 CFR 145.4 - Deviations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Deviations. 145.4 Section 145.4 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 145.4 Deviations. The Office of Management and Budget (OMB) may grant exceptions for classes...

  7. 22 CFR 518.4 - Deviations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Deviations. 518.4 Section 518.4 Foreign Relations BROADCASTING BOARD OF GOVERNORS UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 518.4 Deviations....

  8. 48 CFR 1901.404 - Class deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... BROADCASTING BOARD OF GOVERNORS ACQUISITION REGULATION SYSTEM Deviations From the FAR 1901.404 Class deviations... Procurement Executive, unless FAR 1.405(e) is applicable, and shall be subject to the limitations set forth in FAR 1.404. Requests shall include the same information as cited in 1901.403....

  9. 48 CFR 1201.403 - Individual deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Executive Service (SES) official or that of a Flag Officer, may authorize individual deviations (unless (FAR) 48 CFR 1.405(e) applies). However, see TAM 1201.403. ... FEDERAL ACQUISITION REGULATIONS SYSTEM 70-Deviations From the FAR and TAR 1201.403 Individual...

  10. 48 CFR 3001.404 - Class deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... is authorized to approve FAR class deviations, except (FAR) 48 CFR 30.201-3, and 30.201-4 (the requirements of the Cost Accounting Standards Board); 48 CFR Chapter 99 (FAR Appendix); and part 50. Prior to... class deviation requests shall be submitted to the CPO per (HSAR) 48 CFR subpart 3001.70...

  11. 34 CFR 74.4 - Deviations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Deviations. 74.4 Section 74.4 Education Office of the Secretary, Department of Education ADMINISTRATION OF GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 74.4 Deviations. The Secretary,...

  12. 22 CFR 145.4 - Deviations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Deviations. 145.4 Section 145.4 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 145.4 Deviations. The Office of Management...

  13. 48 CFR 2001.403 - Individual deviations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Individual deviations. 2001.403 Section 2001.403 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION GENERAL NUCLEAR REGULATORY COMMISSION ACQUISITION REGULATION SYSTEM Deviations From the FAR and the NRCAR...

  14. 48 CFR 2001.404 - Class deviations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Class deviations. 2001.404 Section 2001.404 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION GENERAL NUCLEAR REGULATORY COMMISSION ACQUISITION REGULATION SYSTEM Deviations From the FAR and the NRCAR 2001.404...

  15. 10 CFR 605.4 - Deviations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... would be a deviation from 10 CFR part 600, the deviation must also be authorized in accordance with the... ENERGY (CONTINUED) ASSISTANCE REGULATIONS THE OFFICE OF ENERGY RESEARCH FINANCIAL ASSISTANCE PROGRAM... or Deputy Director of ER or the Head of a Contracting Activity upon the written request of DOE...

  16. 2 CFR 215.4 - Deviations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Deviations. 215.4 Section 215.4 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE Reserved UNIFORM ADMINISTRATIVE... ORGANIZATIONS (OMB CIRCULAR A-110) General § 215.4 Deviations. The Office of Management and Budget (OMB)...

  17. 41 CFR 105-1.110 - Deviation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Deviation. 105-1.110 Section 105-1.110 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1.110 Deviation....

  18. 48 CFR 2901.404 - Class deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... through the Director, DAMS. (b) Requests for deviations under paragraph (a) of this section must be... contracting actions which will be affected. (c) For a FAR class deviation the Director, DAMS will consult with... Director, DAMS as required in FAR 1.404....

  19. 10 CFR 609.18 - Deviations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Deviations. 609.18 Section 609.18 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS LOAN GUARANTEES FOR PROJECTS THAT EMPLOY INNOVATIVE TECHNOLOGIES § 609.18 Deviations. To the extent that such requirements are not specified by the Act or other applicable statutes, DOE may authorize...

  20. Management of mandibular deviation after mandibulectomy by simplified approach.

    PubMed

    Arora, Varuni; Singh, Kamleshwar; Agrawal, Kaushal Kishor; Alvi, Habib Ahmed

    2013-01-01

    Unfavourable sequelae from mandibular surgeries include malocclusion and temporomandibular joint dysfunction. The management of the situation before these complications arise is largely based on experience. This report presents a case where mandibular deviation is decreased through an additional row of teeth in the maxillary removable partial denture, and by decreasing scar contracture in the surgical site by means of a simple exercise. PMID:23625665

  1. Large perpendicular magnetic anisotropy of single Co atom on MgO monolayer: A first-principles study

    SciTech Connect

    Shao, Bin; Shi, Wu-Jun; Feng, Min; Zuo, Xu

    2015-05-07

    Realizing the magnetic bit with a single atom is the ultimate goal for magnetic storage. Based on density functional theory, the magnetic anisotropy (MA) of single Co atom on MgO monolayer has been investigated. Results show that this two dimensional system possesses a large perpendicular MA, about 5.8 meV per Co atom. Besides, there exists remarkable unquenched orbital moments for different magnetization directions, which can be attributed to the reduction of coordination number in two dimensional system and is responsible for the enhanced MA. The Bloch pseudo-wavefunction and band structure of Co d-orbitals have been calculated to elucidate the origin of the perpendicular MA.

  2. Raypath deviation under stable and unstable conditions

    NASA Astrophysics Data System (ADS)

    Dion, Denis; Seiffer, Dirk; Stein, Karin; Forand, Luc; Potvin, Guy

    2005-10-01

    Ray-bending resulting from atmospheric refraction in the maritime environment has been shown to potentially produce significant effects on electro-optical target detection and imaging. Positive bending makes possible detection beyond the horizon while negative bending reduces the maximum inter-vision range (MIVR) and is likely to produce severe image distortion or mirages. It has been shown by many authors that these phenomena can be efficiently described using ray-tracing in conjunction with bulk estimations of the refractivity profiles based on the Monin-Obhukov theory. In this paper, the accuracy of bulk methods to describe ray bending is assessed by examining angular deviations of apparent target elevations with respect to the meteorological conditions. Prediction accuracy is shown for a large spectrum of conditions, characterized by the air-sea temperature difference, by combining measurements collected in the North Sea and in the Baltic Sea. Moreover, the use of bulk profiles as opposed to profiles measured at sea by using a buoy is discussed.

  3. Assessing the impact of large-scale computing on the size and complexity of first-principles electromagnetic models

    NASA Astrophysics Data System (ADS)

    Miller, E. K.

    There is a growing need to determine the electromagnetic performance of increasingly complex systems at ever higher frequencies. The ideal approach would be some appropriate combination of measurement, analysis, and computation so that system design and assessment can be achieved to a needed degree of accuracy at some acceptable cost. Both measurement and computation benefit from the continuing growth in computer power that, since the early 1950s, has increased by a factor of more than a million in speed and storage. For example, a CRAY2 has an effective throughput (not the clock rate) of about 10(exp 11) floating point operations (FLOPs) per hour compared with the approx. 10(exp 5) provided by the UNIVAC-1. The purpose of this discussion is to illustrate the computational complexity of modeling large (in wavelengths) electromagnetic problems. In particular the point is made that simply relying on faster computers for increasing the size and complexity of problems that can be modeled is less effective than might be anticipated from this raw increase in computer throughput. It is suggested that rather than depending on faster computers alone, various analytical and numerical alternatives need development for reducing the overall FLOP count required to acquire the information desired. One approach is to decrease the operation count of the basic model computation itself, by reducing the order of the frequency dependence of the various numerical operations or their multiplying coefficients. Another is to decrease the number of model evaluations that are needed, an example being the number of frequency samples required to define a wideband response, by using an auxiliary model of the expected behavior.

  4. Scaling Deviations for Neutrino Reactions in Aysmptotically Free Field Theories

    DOE R&D Accomplishments Database

    Wilczek, F. A.; Zee, A.; Treiman, S. B.

    1974-11-01

    Several aspects of deep inelastic neutrino scattering are discussed in the framework of asymptotically free field theories. We first consider the growth behavior of the total cross sections at large energies. Because of the deviations from strict scaling which are characteristic of such theories the growth need not be linear. However, upper and lower bounds are established which rather closely bracket a linear growth. We next consider in more detail the expected pattern of scaling deviation for the structure functions and, correspondingly, for the differential cross sections. The analysis here is based on certain speculative assumptions. The focus is on qualitative effects of scaling breakdown as they may show up in the X and y distributions. The last section of the paper deals with deviations from the Callan-Gross relation.

  5. The influence of geology on blasthole deviation

    SciTech Connect

    Singh, S.P.

    1996-12-31

    Blasthole deviation is a frequent, well documented and undesirable occurrence in mining operations. It is caused by the drill string mechanics, operating variables and the interaction between the drill bit and the rock mass characteristics. It is composed of three distinct components: collaring or marking error, alignment error and trajectory deviation. This study has focused on the dependence of trajectory or natural deviation on the geological features of the rock mass being drilled. The methodology involved the study of visible half barrels at road cuts, open pits, quarries, underground drifting and breasting operations. The effects of the following geological features on drillhole deviation have been investigated and discussed in this paper (1) strength and hardness of rocks (2) alternate layers of hard and soft rocks (3) anisotropy in rock mass (4) thickness and inclination of layers and bedding planes and (5) joints or other geological boundaries.

  6. Tertiary recovery method using inverted deviated holes

    SciTech Connect

    Goodhart, M.E.

    1987-03-13

    A method is described of recovering oil and the like from a subsurface earth formation comprising the steps of: establishing a substantially vertical shaft hole extending from the surface of the earth of the subsurface earth formation, boring from the vertical shaft initially in an essentially upward direction in the formation at least one deviated hole in the formation, the deviated hole having an upper end and communicating at its lower end with the vertical shaft, forming from an upper end in the vertical shaft in an essentially downward direction an outer borehole in the subsurface earth formation in proximity with the deviated hole, the outer borehole communicating with the vertical shaft and horizontally overlapping the deviated hole, and directing recovery enhancing fluids from the surface through the upper end of the vertical shaft to the outer borehole and injecting the fluids into the formation in proximity with the deviated hole whereby the fluids injected into the earth formation in proximity with the hole facilitates drainage of oil and the like into the upwardly directed deviated hole.

  7. Role of Extracorporeal Septoplasty in Deviated Noses.

    PubMed

    Ghaisas, Virendra; Parab, Sapna Ramkrishna

    2015-09-01

    Severe gross septal deviations present big surgical challenges for operating surgeon. Septal deviations has direct effect on aesthetic and functional part of nose. Correcting septal deviations during rhinoplasty is basic procedure. Extreme deviations of septum especially on dorsal and caudal end of cartilaginous septum are difficult to treat. The classical septoplasty approach becomes unsuitable for such severe deviations. Gubisch has first reported in 1995 about extracorporeal septoplasty. To report the experience of Extracorporeal septoplasty and the complication rates with the technique. Retrospective study of 112 patients who underwent extracorporeal septoplasty in primary rhinoplasty from May 2009 to June 2014. Patient's pre and postoperatively evaluation was done by photographs, nasal endoscopy and subjective by symptoms evaluation satisfaction scale 6 and 12 months postoperatively. Nasal endoscopy revealed significant improvement in nasal airway and nasal valve and subjective evaluation satisfaction score was very encouraging. Complications like septal perforation, bleeding, aesthetic complications were minimal (9 %) On basis of results obtained, shows that this technique, increases patients nasal airway and aesthetic look of the patients. Irrespective of extreme nasal deviations. PMID:26405652

  8. Attacks exploiting deviation of mean photon number in quantum key distribution and coin tossing

    NASA Astrophysics Data System (ADS)

    Sajeed, Shihan; Radchenko, Igor; Kaiser, Sarah; Bourgoin, Jean-Philippe; Pappa, Anna; Monat, Laurent; Legré, Matthieu; Makarov, Vadim

    2015-03-01

    The security of quantum communication using a weak coherent source requires an accurate knowledge of the source's mean photon number. Finite calibration precision or an active manipulation by an attacker may cause the actual emitted photon number to deviate from the known value. We model effects of this deviation on the security of three quantum communication protocols: the Bennett-Brassard 1984 (BB84) quantum key distribution (QKD) protocol without decoy states, Scarani-Acín-Ribordy-Gisin 2004 (SARG04) QKD protocol, and a coin-tossing protocol. For QKD we model both a strong attack using technology possible in principle and a realistic attack bounded by today's technology. To maintain the mean photon number in two-way systems, such as plug-and-play and relativistic quantum cryptography schemes, bright pulse energy incoming from the communication channel must be monitored. Implementation of a monitoring detector has largely been ignored so far, except for ID Quantique's commercial QKD system Clavis2. We scrutinize this implementation for security problems and show that designing a hack-proof pulse-energy-measuring detector is far from trivial. Indeed, the first implementation has three serious flaws confirmed experimentally, each of which may be exploited in a cleverly constructed Trojan-horse attack. We discuss requirements for a loophole-free implementation of the monitoring detector.

  9. Online Deviation Detection for Medical Processes

    PubMed Central

    Christov, Stefan C.; Avrunin, George S.; Clarke, Lori A.

    2014-01-01

    Human errors are a major concern in many medical processes. To help address this problem, we are investigating an approach for automatically detecting when performers of a medical process deviate from the acceptable ways of performing that process as specified by a detailed process model. Such deviations could represent errors and, thus, detecting and reporting deviations as they occur could help catch errors before harm is done. In this paper, we identify important issues related to the feasibility of the proposed approach and empirically evaluate the approach for two medical procedures, chemotherapy and blood transfusion. For the evaluation, we use the process models to generate sample process executions that we then seed with synthetic errors. The process models describe the coordination of activities of different process performers in normal, as well as in exceptional situations. The evaluation results suggest that the proposed approach could be applied in clinical settings to help catch errors before harm is done. PMID:25954343

  10. Fatigue, pilot deviations and time of day

    NASA Technical Reports Server (NTRS)

    Baker, Susan P.

    1989-01-01

    The relationships between pilot fatigue, pilot deviations, reported incidents, and time of day are examined. A sample of 200 Aviation Safety Reporting System (ASRS) reports were analyzed from 1985 and 200 reports from 1987, plus 100 reports from late 1987 and early 1988 that were selected because of possible association with fatigue. The FAA pilot deviation data and incident data were analyzed in relation to denominator data that summarized the hourly operations (landings and takeoffs of scheduled flights) at major U.S. airports. Using as numerators FAA data on pilot deviations and incidents reported to the FAA, the rates by time of day were calculated. Pilot age was also analyzed in relation to the time of day, phase of flight, and type of incident.

  11. Bernoulli's Principle

    ERIC Educational Resources Information Center

    Hewitt, Paul G.

    2004-01-01

    Some teachers have difficulty understanding Bernoulli's principle particularly when the principle is applied to the aerodynamic lift. Some teachers favor using Newton's laws instead of Bernoulli's principle to explain the physics behind lift. Some also consider Bernoulli's principle too difficult to explain to students and avoid teaching it…

  12. 20 CFR 435.4 - Deviations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Deviations. 435.4 Section 435.4 Employees' Benefits SOCIAL SECURITY ADMINISTRATION UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER NON-PROFIT ORGANIZATIONS, AND COMMERCIAL...

  13. 49 CFR 19.4 - Deviations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Deviations. 19.4 Section 19.4 Transportation Office of the Secretary of Transportation UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General §...

  14. 48 CFR 3001.403 - Individual deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CFR 30.201-3, 30.201-4; the requirements of the Cost Accounting Standards board rules and regulations at 48 CFR chapter 99 (FAR appendix); and part 50). Submit requests per (HSAR) 48 CFR 3001.7000... from the FAR and HSAR 3001.403 Individual deviations. Unless precluded by law, executive order,...

  15. 41 CFR 109-1.5304 - Deviations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... High Risk Personal Property § 109-1.5304 Deviations. (a) Life cycle control determinations. When the HFO approves a contractor program containing controls, other than life cycle control consistent with... Secretary for Procurement and Assistance Management. A HFO's decision not to provide life-cycle...

  16. 41 CFR 109-1.5304 - Deviations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... High Risk Personal Property § 109-1.5304 Deviations. (a) Life cycle control determinations. When the HFO approves a contractor program containing controls, other than life cycle control consistent with... Secretary for Procurement and Assistance Management. A HFO's decision not to provide life-cycle...

  17. 41 CFR 109-1.5304 - Deviations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... High Risk Personal Property § 109-1.5304 Deviations. (a) Life cycle control determinations. When the HFO approves a contractor program containing controls, other than life cycle control consistent with... Secretary for Procurement and Assistance Management. A HFO's decision not to provide life-cycle...

  18. 48 CFR 201.404 - Class deviations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Air Force, and the Directors of the Defense Commissary Agency, the Defense Contract Management Agency, and the Defense Logistics Agency, may approve any class deviation, other than those described in 201... department or agency; (B) Have a significant cost or administrative impact on contractors or offerors;...

  19. 48 CFR 201.404 - Class deviations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Air Force, and the Directors of the Defense Commissary Agency, the Defense Contract Management Agency, and the Defense Logistics Agency, may approve any class deviation, other than those described in 201... department or agency; (B) Have a significant cost or administrative impact on contractors or offerors;...

  20. Manifestations of Deviation in the Adolescent Subculture

    ERIC Educational Resources Information Center

    Sobkin, V. S.; Abrosimova, Z. B.; Adamchuk, D. V.; Baranova, E. V.

    2005-01-01

    In this article the authors look at questions relating to school students' attitudes toward types of deviation such as smoking and the use of alcohol and narcotics. The empirical material is divided into the following topics: how widespread these forms of behavior are; motives that cause adolescents to start smoking, using alcohol, and taking…

  1. 20 CFR 435.4 - Deviations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Deviations. 435.4 Section 435.4 Employees' Benefits SOCIAL SECURITY ADMINISTRATION UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH... will be permitted only in unusual circumstances. SSA may apply more restrictive requirements to a...

  2. 41 CFR 109-1.5304 - Deviations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... High Risk Personal Property § 109-1.5304 Deviations. (a) Life cycle control determinations. When the HFO approves a contractor program containing controls, other than life cycle control consistent with... Secretary for Procurement and Assistance Management. A HFO's decision not to provide life-cycle...

  3. 41 CFR 101-1.110 - Deviation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Deviation. 101-1.110 Section 101-1.110 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1-Regulation System § 101-1.110...

  4. 41 CFR 101-1.110 - Deviation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 2 2012-07-01 2012-07-01 false Deviation. 101-1.110 Section 101-1.110 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1-Regulation System § 101-1.110...

  5. 41 CFR 101-1.110 - Deviation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Deviation. 101-1.110 Section 101-1.110 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1-Regulation System § 101-1.110...

  6. 41 CFR 101-1.110 - Deviation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 2 2014-07-01 2012-07-01 true Deviation. 101-1.110 Section 101-1.110 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1-Regulation System § 101-1.110...

  7. 14 CFR 1260.7 - Deviations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...” within the meaning of the Paperwork Reduction Act (44 U.S.C. 35) and its implementation in 5 CFR part... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Deviations. 1260.7 Section 1260.7 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS...

  8. 14 CFR 1260.7 - Deviations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...” within the meaning of the Paperwork Reduction Act (44 U.S.C. 35) and its implementation in 5 CFR part... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Deviations. 1260.7 Section 1260.7 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS...

  9. 14 CFR 1260.7 - Deviations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...” within the meaning of the Paperwork Reduction Act (44 U.S.C. 35) and its implementation in 5 CFR part... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Deviations. 1260.7 Section 1260.7 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS...

  10. 14 CFR § 1260.7 - Deviations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...” within the meaning of the Paperwork Reduction Act (44 U.S.C. 35) and its implementation in 5 CFR part... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Deviations. § 1260.7 Section § 1260.7 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS...

  11. 14 CFR 1260.7 - Deviations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...” within the meaning of the Paperwork Reduction Act (44 U.S.C. 35) and its implementation in 5 CFR part... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Deviations. 1260.7 Section 1260.7 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS...

  12. Bodily Deviations and Body Image in Adolescence

    ERIC Educational Resources Information Center

    Vilhjalmsson, Runar; Kristjansdottir, Gudrun; Ward, Dianne S.

    2012-01-01

    Adolescents with unusually sized or shaped bodies may experience ridicule, rejection, or exclusion based on their negatively valued bodily characteristics. Such experiences can have negative consequences for a person's image and evaluation of self. This study focuses on the relationship between bodily deviations and body image and is based on a…

  13. 7 CFR 2502.3 - Deviations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Deviations. 2502.3 Section 2502.3 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ADVOCACY AND OUTREACH, DEPARTMENT OF AGRICULTURE AGRICULTURAL CAREER AND EMPLOYMENT (ACE) GRANTS PROGRAM General Information § 2502.3...

  14. Band crossing in isovalent semiconductor alloys with large size mismatch: First-principles calculations of the electronic structure of Bi and N incorporated GaAs

    NASA Astrophysics Data System (ADS)

    Deng, Hui-Xiong; Li, Jingbo; Li, Shu-Shen; Peng, Haowei; Xia, Jian-Bai; Wang, Lin-Wang; Wei, Su-Huai

    2010-11-01

    For large size- and chemical-mismatched isovalent semiconductor alloys, such as N and Bi substitution on As sites in GaAs, isovalent defect levels or defect bands are introduced. The evolution of the defect states as a function of the alloy concentration is usually described by the popular phenomenological band anticrossing (BAC) model. Using first-principles band-structure calculations we show that at the impurity limit the N- (Bi)-induced impurity level is above (below) the conduction- (valence-) band edge of GaAs. These trends reverse at high concentration, i.e., the conduction-band edge of GaAs1-xNx becomes an N-derived state and the valence-band edge of GaAs1-xBix becomes a Bi-derived state, as expected from their band characters. We show that this band crossing phenomenon cannot be described by the popular BAC model but can be naturally explained by a simple band broadening picture.

  15. Determination of real machine-tool settings and minimization of real surface deviation by computerized inspection

    NASA Technical Reports Server (NTRS)

    Litvin, Faydor L.; Kuan, Chihping; Zhang, YI

    1991-01-01

    A numerical method is developed for the minimization of deviations of real tooth surfaces from the theoretical ones. The deviations are caused by errors of manufacturing, errors of installment of machine-tool settings and distortion of surfaces by heat-treatment. The deviations are determined by coordinate measurements of gear tooth surfaces. The minimization of deviations is based on the proper correction of initially applied machine-tool settings. The contents of accomplished research project cover the following topics: (1) Descriptions of the principle of coordinate measurements of gear tooth surfaces; (2) Deviation of theoretical tooth surfaces (with examples of surfaces of hypoid gears and references for spiral bevel gears); (3) Determination of the reference point and the grid; (4) Determination of the deviations of real tooth surfaces at the points of the grid; and (5) Determination of required corrections of machine-tool settings for minimization of deviations. The procedure for minimization of deviations is based on numerical solution of an overdetermined system of n linear equations in m unknowns (m much less than n ), where n is the number of points of measurements and m is the number of parameters of applied machine-tool settings to be corrected. The developed approach is illustrated with numerical examples.

  16. Deviations from LTE in a stellar atmosphere

    NASA Technical Reports Server (NTRS)

    Kalkofen, W.; Klein, R. I.; Stein, R. F.

    1979-01-01

    Deviations for LTE are investigated in an atmosphere of hydrogen atoms with one bound level, satisfying the equations of radiative, hydrostatic, and statistical equilibrium. The departure coefficient and the kinetic temperature as functions of the frequency dependence of the radiative cross section are studied analytically and numerically. Near the outer boundary of the atmosphere, the departure coefficient is smaller than unity when the radiative cross section grows with frequency faster than with the square of frequency; it exceeds unity otherwise. Far from the boundary the departure coefficient tends to exceed unity for any frequency dependence of the radiative cross section. Overpopulation always implies that the kinetic temperature in the statistical-equilibrium atmosphere is higher than the temperature in the corresponding LTE atmosphere. Upper and lower bounds on the kinetic temperature are given for an atmosphere with deviations from LTE only in the optically shallow layers when the emergent intensity can be described by a radiation temperature.

  17. Equivalence Principle and Gravitational Redshift

    SciTech Connect

    Hohensee, Michael A.; Chu, Steven; Mueller, Holger; Peters, Achim

    2011-04-15

    We investigate leading order deviations from general relativity that violate the Einstein equivalence principle in the gravitational standard model extension. We show that redshift experiments based on matter waves and clock comparisons are equivalent to one another. Consideration of torsion balance tests, along with matter-wave, microwave, optical, and Moessbauer clock tests, yields comprehensive limits on spin-independent Einstein equivalence principle-violating standard model extension terms at the 10{sup -6} level.

  18. Electron density and transport in top-gated graphene nanoribbon devices: First-principles Green function algorithms for systems containing a large number of atoms

    NASA Astrophysics Data System (ADS)

    Areshkin, Denis A.; Nikolić, Branislav K.

    2010-04-01

    The recent fabrication of graphene nanoribbon (GNR) field-effect transistors poses a challenge for first-principles modeling of carbon nanoelectronics due to many thousand atoms present in the device. The state of the art quantum transport algorithms, based on the nonequilibrium Green function formalism combined with the density-functional theory (NEGF-DFT), were originally developed to calculate self-consistent electron density in equilibrium and at finite bias voltage (as a prerequisite to obtain conductance or current-voltage characteristics, respectively) for small molecules attached to metallic electrodes where only a few hundred atoms are typically simulated. Here we introduce combination of two numerically efficient algorithms which make it possible to extend the NEGF-DFT framework to device simulations involving large number of atoms. Our first algorithm offers an alternative to the usual evaluation of the equilibrium part of electron density via numerical contour integration of the retarded Green function in the upper complex half-plane. It is based on the replacement of the Fermi function f(E) with an analytic function f˜(E) coinciding with f(E) inside the integration range along the real axis, but decaying exponentially in the upper complex half-plane. Although f˜(E) has infinite number of poles, whose positions and residues are determined analytically, only a finite number of those poles have non-negligible residues. We also discuss how this algorithm can be extended to compute the nonequilibrium contribution to electron density, thereby evading cumbersome real-axis integration (within the bias voltage window) of NEGFs which is very difficult to converge for systems with large number of atoms while maintaining current conservation. Our second algorithm combines the recursive formulas with the geometrical partitioning of an arbitrary multiterminal device into nonuniform segments in order to reduce the computational complexity of the retarded Green

  19. Note Onset Deviations as Musical Piece Signatures

    PubMed Central

    Serrà, Joan; Özaslan, Tan Hakan; Arcos, Josep Lluis

    2013-01-01

    A competent interpretation of a musical composition presents several non-explicit departures from the written score. Timing variations are perhaps the most important ones: they are fundamental for expressive performance and a key ingredient for conferring a human-like quality to machine-based music renditions. However, the nature of such variations is still an open research question, with diverse theories that indicate a multi-dimensional phenomenon. In the present study, we consider event-shift timing variations and show that sequences of note onset deviations are robust and reliable predictors of the musical piece being played, irrespective of the performer. In fact, our results suggest that only a few consecutive onset deviations are already enough to identify a musical composition with statistically significant accuracy. We consider a mid-size collection of commercial recordings of classical guitar pieces and follow a quantitative approach based on the combination of standard statistical tools and machine learning techniques with the semi-automatic estimation of onset deviations. Besides the reported results, we believe that the considered materials and the methodology followed widen the testing ground for studying musical timing and could open new perspectives in related research fields. PMID:23935971

  20. Note onset deviations as musical piece signatures.

    PubMed

    Serrà, Joan; Özaslan, Tan Hakan; Arcos, Josep Lluis

    2013-01-01

    A competent interpretation of a musical composition presents several non-explicit departures from the written score. Timing variations are perhaps the most important ones: they are fundamental for expressive performance and a key ingredient for conferring a human-like quality to machine-based music renditions. However, the nature of such variations is still an open research question, with diverse theories that indicate a multi-dimensional phenomenon. In the present study, we consider event-shift timing variations and show that sequences of note onset deviations are robust and reliable predictors of the musical piece being played, irrespective of the performer. In fact, our results suggest that only a few consecutive onset deviations are already enough to identify a musical composition with statistically significant accuracy. We consider a mid-size collection of commercial recordings of classical guitar pieces and follow a quantitative approach based on the combination of standard statistical tools and machine learning techniques with the semi-automatic estimation of onset deviations. Besides the reported results, we believe that the considered materials and the methodology followed widen the testing ground for studying musical timing and could open new perspectives in related research fields. PMID:23935971

  1. Geometry of river networks. I. Scaling, fluctuations, and deviations

    SciTech Connect

    Dodds, Peter Sheridan; Rothman, Daniel H.

    2001-01-01

    This paper is the first in a series of three papers investigating the detailed geometry of river networks. Branching networks are a universal structure employed in the distribution and collection of material. Large-scale river networks mark an important class of two-dimensional branching networks, being not only of intrinsic interest but also a pervasive natural phenomenon. In the description of river network structure, scaling laws are uniformly observed. Reported values of scaling exponents vary, suggesting that no unique set of scaling exponents exists. To improve this current understanding of scaling in river networks and to provide a fuller description of branching network structure, here we report a theoretical and empirical study of fluctuations about and deviations from scaling. We examine data for continent-scale river networks such as the Mississippi and the Amazon and draw inspiration from a simple model of directed, random networks. We center our investigations on the scaling of the length of a subbasin's dominant stream with its area, a characterization of basin shape known as Hack's law. We generalize this relationship to a joint probability density, and provide observations and explanations of deviations from scaling. We show that fluctuations about scaling are substantial, and grow with system size. We find strong deviations from scaling at small scales which can be explained by the existence of a linear network structure. At intermediate scales, we find slow drifts in exponent values, indicating that scaling is only approximately obeyed and that universality remains indeterminate. At large scales, we observe a breakdown in scaling due to decreasing sample space and correlations with overall basin shape. The extent of approximate scaling is significantly restricted by these deviations, and will not be improved by increases in network resolution.

  2. Variability of Ocular Deviation in Strabismus

    PubMed Central

    Economides, John R.; Adams, Daniel L.; Horton, Jonathan C.

    2015-01-01

    IMPORTANCE In strabismus, the fixating eye conveys the direction of gaze while the fellow eye points at a peripheral location in space. The stability of the eyes may be reduced by the absence of a common target. OBJECTIVE To quantify the stability of eye position in strabismus and to measure variability in the ocular deviation. DESIGN, SETTING, AND PARTICIPANTS From 2010 to 2014, a prospective comparative case study of 25 patients with alternating exotropia with normal visual acuity in each eye and 25 control individuals was conducted in a laboratory at a tertiary eye center. A video eye tracker was used to measure the position of each eye while participants alternated fixation on the center of a cross under dichoptic conditions or scanned pictures of natural scenes. MAIN OUTCOMES AND MEASURES Spatial and temporal variability in the position of the fixating eye and the nonfixating eye in patients with strabismus and control individuals, quantified by the log area of ellipses containing 95% of eye positions or mean SDs of eye position. RESULTS In the 25 patients with strabismus, the mean (SD) age was 28 (14) years (range, 8–55 years) and the mean (SD) ocular deviation was 14.2° (5.9°) (range, 4.4°–22.4°). In the patients with strabismus, the mean position variability (1.80 log units; 95% CI, 1.66–1.93) for the deviating eye was greater than for the fixating eye (1.26 log units; 95% CI, 1.17–1.35) (P < .001). The fixating eye of patients with strabismus was more variable in position than the fixating eye of individuals without strabismus (0.98 log units; 95% CI, 0.88–1.08) (P < .005). CONCLUSIONS AND RELEVANCE In patients with strabismus, even without amblyopia, the deviated eye is more variable in position than the fixating eye. Both eyes are less stable in position than the eyes of control individuals, which indicates that strabismus impairs the ability to fixate targets steadily. Saccades contribute to variability of the deviation angle because they

  3. Electromagnetic modelling of superconductors with a smooth current-voltage relation: variational principle and coils from a few turns to large magnets

    NASA Astrophysics Data System (ADS)

    Pardo, Enric; Šouc, Ján; Frolek, Lubomir

    2015-04-01

    Many large-scale applications require electromagnetic modelling with extensive numerical computations, such as magnets or three-dimensional (3D) objects like transposed conductors or motors and generators. Therefore, it is necessary to develop computationally time-efficient but still accurate numerical methods. This article develops a general variational formalism for any {E}({J}) relation and applies it to model coated-conductor coils containing up to thousands of turns, taking magnetization currents fully into account. The variational principle, valid for any 3D situation, restricts the computations to the sample volume, reducing the computation time. However, no additional magnetic materials interacting with the superconductor are taken directly into account. Regarding the coil modelling, we use a power law E(J) relation with magnetic field-dependent critical current density, Jc, and power law exponent, n. We test the numerical model by comparing the results to analytical formulas for thin strips and experiments for stacks of pancake coils, finding a very good agreement. Afterwards, we model a magnet-size coil of 4000 turns (stack of 20 pancake coils of 200 turns each). We found that the ac loss is mainly due to magnetization currents. We also found that for an n exponent of 20, the magnetization currents are greatly suppressed after 1 h relaxation. In addition, in coated conductor coils magnetization currents have an important impact on the generated magnetic field; which should be taken into account for magnet design. In conclusion, the presented numerical method fulfills the requirements for electromagnetic design of coated conductor windings.

  4. Standard deviation of scatterometer measurements from space.

    NASA Technical Reports Server (NTRS)

    Fischer, R. E.

    1972-01-01

    The standard deviation of scatterometer measurements has been derived under assumptions applicable to spaceborne scatterometers. Numerical results are presented which show that, with sufficiently long integration times, input signal-to-noise ratios below unity do not cause excessive degradation of measurement accuracy. The effects on measurement accuracy due to varying integration times and changing the ratio of signal bandwidth to IF filter-noise bandwidth are also plotted. The results of the analysis may resolve a controversy by showing that in fact statistically useful scatterometer measurements can be made from space using a 20-W transmitter, such as will be used on the S-193 experiment for Skylab-A.

  5. Measuring and Plotting Surface-Contour Deviations

    NASA Technical Reports Server (NTRS)

    Aragon, Lino A.; Shuck, Thomas; Crockett, Leroy K.

    1987-01-01

    Hand-held device measures deviation of contour of surface from desired contour and provides output to x-y plotter. Carriage on device rolled along track representing desired contour, while spring-loaded stylus on device deflects perpendicularly to track to follow surface. Operator moves carriage of contour-measuring device on beamlike track. Stylus on carriage traces contour of surface above it. Carriage of measuring device holds transducer measuring cross-track displacement of surface from desired contour, and multiple-turn potentiometer measuring position along track.

  6. 2D design rule and layout analysis using novel large-area first-principles-based simulation flow incorporating lithographic and stress effects

    NASA Astrophysics Data System (ADS)

    Prins, Steven L.; Blatchford, James; Olubuyide, Oluwamuyiwa; Riley, Deborah; Chang, Simon; Hong, Qi-Zhong; Kim, T. S.; Borges, Ricardo; Lin, Li

    2009-03-01

    As design rules and corresponding logic standard cell layouts continue to shrink node-on-node in accordance with Moore's law, complex 2D interactions, both intra-cell and between cells, become much more prominent. For example, in lithography, lack of scaling of λ/NA implies aggressive use of resolution enhancement techniques to meet logic scaling requirements-resulting in adverse effects such as 'forbidden pitches'-and also implies an increasing range of optical influence relative to cell size. These adverse effects are therefore expected to extend well beyond the cell boundary, leading to lithographic marginalities that occur only when a given cell is placed "in context" with other neighboring cells in a variable design environment [1]. This context dependence is greatly exacerbated by increased use of strain engineering techniques such as SiGe and dual-stress liners (DSL) to enhance transistor performance, both of which also have interaction lengths on the order of microns. The use of these techniques also breaks the formerly straightforward connection between lithographic 'shapes' and end-of-line electrical performance, thus making the formulation of design rules that are robust to process variations and complex 2D interactions more difficult. To address these issues, we have developed a first-principles-based simulation flow to study contextdependent electrical effects in layout, arising not only from lithography, but also from stress and interconnect parasitic effects. This flow is novel in that it can be applied to relatively large layout clips- required for context-dependent analysis-without relying on semi-empirical or 'black-box' models for the fundamental electrical effects. The first-principles-based approach is ideal for understanding contextdependent effects early in the design phase, so that they can be mitigated through restrictive design rules. The lithographic simulations have been discussed elsewhere [1] and will not be presented in detail. The

  7. 48 CFR 2801.470 - Requests for class deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DEPARTMENT OF JUSTICE ACQUISITION REGULATIONS SYSTEM Deviations From the FAR and JAR 2801.470 Requests for class deviations. Requests for approval of class deviations from the FAR or the JAR shall be forwarded... deviations shall be submitted as far in advance as the exigencies of the situation permit and shall...

  8. Spotting deviations from R2 inflation

    NASA Astrophysics Data System (ADS)

    de la Cruz-Dombriz, Álvaro; Elizalde, Emilio; Odintsov, Sergei D.; Sáez-Gómez, Diego

    2016-05-01

    We discuss the soundness of inflationary scenarios in theories beyond the Starobinsky model, namely a class of theories described by arbitrary functions of the Ricci scalar and the K-essence field. We discuss the pathologies associated with higher-order equations of motion which will be shown to constrain the stability of this class of theories. We provide a general framework to calculate the slow-roll parameters and the corresponding mappings to the theory parameters. For paradigmatic gravitational models within the class of theories under consideration we illustrate the power of the Planck/Bicep2 latest results to constrain such gravitational Lagrangians. Finally, bounds for potential deviations from Starobinsky-like inflation are derived.

  9. Buridan's Principle

    NASA Astrophysics Data System (ADS)

    Lamport, Leslie

    2012-08-01

    Buridan's principle asserts that a discrete decision based upon input having a continuous range of values cannot be made within a bounded length of time. It appears to be a fundamental law of nature. Engineers aware of it can design devices so they have an infinitessimal probability of not making a decision quickly enough. Ignorance of the principle could have serious consequences.

  10. Principled Narrative

    ERIC Educational Resources Information Center

    MacBeath, John; Swaffield, Sue; Frost, David

    2009-01-01

    This article provides an overview of the "Carpe Vitam: Leadership for Learning" project, accounting for its provenance and purposes, before focusing on the principles for practice that constitute an important part of the project's legacy. These principles framed the dialogic process that was a dominant feature of the project and are presented,…

  11. Dynamic sealing principles

    NASA Technical Reports Server (NTRS)

    Zuk, J.

    1976-01-01

    The fundamental principles governing dynamic sealing operation are discussed. Different seals are described in terms of these principles. Despite the large variety of detailed construction, there appear to be some basic principles, or combinations of basic principles, by which all seals function, these are presented and discussed. Theoretical and practical considerations in the application of these principles are discussed. Advantages, disadvantages, limitations, and application examples of various conventional and special seals are presented. Fundamental equations governing liquid and gas flows in thin film seals, which enable leakage calculations to be made, are also presented. Concept of flow functions, application of Reynolds lubrication equation, and nonlubrication equation flow, friction and wear; and seal lubrication regimes are explained.

  12. Some Deviations Associated With Vector Perturbation Diffraction Theory

    NASA Astrophysics Data System (ADS)

    Stover, John C.; Hourmand, Bahrarr

    1985-01-01

    Last year at this conference our lab presented some data which strongly supports the use of the vector perturbation relationship between light scattered from smooth surfaces and the surface power spectral density (PSD). Last year's data showed that a consistent answer was obtained for the PSD for measurements taken with S and P polarization, with incident angles up to 45', for positive and negative sweeps, and for one and two dimensional samples. If in fact the theoretical relationship is correct then this must be the case, as the PSD is determined by a combination of surface topography and the scattering situation (geometry, polarization, wavelength, etc.). It appears, however that for large scatter angles (>700) and for large angles of incidence (>60 °) there is some deviation in the calculated PSD. In addition, the high angle scatter region is an area where a scatterometer with a semicircular detector sweep loses the one-to-one relationship between detector position and surface spatial frequency. Or, in other words, light diffracted to high scatter angles from single spatial frequencies appears over a small band on the observation semicircle instead of a diffraction limited point. Fata supporting these two deviations is presented. Although they are not regarded as serious violations of the vector perturbation theory they do impose a limit on the useful range over which the PSD may be calculated.

  13. Capturing deviation from ergodicity at different scales

    NASA Astrophysics Data System (ADS)

    Scott, Sherry E.; Redd, Thomas C.; Kuznetsov, Leonid; Mezić, Igor; Jones, Christopher K. R. T.

    2009-08-01

    We address here the issue of quantifying the extent to which a given dynamical system falls short of being ergodic and introduce a new multiscale technique which we call the “ergodicity defect”. Our approach is aimed at capturing both deviation from ergodicity and its dependence on scale. The method uses ergodic theory of dynamical systems and applies harmonic analysis, in particular the scaling analysis is motivated by wavelet theory. We base the definition of the ergodicity defect on the Birkhoff characterization. We systematically exploit the role of the observation function by using characteristic functions arising from a dyadic equipartition of the phase space. This allows us to view the dependence of the defect on scale. In order to build intuition, we consider the defect for specific examples with known dynamic properties and we are able to explicitly compute the defect for some of these simple examples. We focus on three distinctive cases of the dependence of the defect on scale: (1) a defect value that increases as the scale becomes finer, (2) a defect value decreasing with scale and (3) a defect value independent of scale, which occurs for instance when a map is ergodic. We explain the information contained in these three scenarios. We see more complicated behavior with an example which has invariant subsets at various scales.

  14. A strategy to objectively evaluate the necessity of correcting detected target deviations in image guided radiotherapy

    SciTech Connect

    Yue, Ning J.; Kim, Sung; Jabbour, Salma; Narra, Venkat; Haffty, Bruce G.

    2007-11-15

    Image guided radiotherapy technologies are being increasingly utilized in the treatment of various cancers. These technologies have enhanced the ability to detect temporal and spatial deviations of the target volume relative to planned radiation beams. Correcting these detected deviations may, in principle, improve the accuracy of dose delivery to the target. However, in many situations, a clinical decision has to be made as to whether it is necessary to correct some of the deviations since the relevant dosimetric impact may or may not be significant, and the corresponding corrective action may be either impractical or time consuming. Ideally this decision should be based on objective and reproducible criteria rather than subjective judgment. In this study, a strategy is proposed for the objective evaluation of the necessity of deviation correction during the treatment verification process. At the treatment stage, without any alteration from the planned beams, the treatment beams should provide the desired dose coverage to the geometric volume identical to the planning target volume (PTV). Given this fact, the planned dose distribution and PTV geometry were used to compute the dose coverage and PTV enclosure of the clinical target volume (CTV) that was detected from imaging during the treatment setup verification. The spatial differences between the detected CTV and the planning CTV are essentially the target deviations. The extent of the PTV enclosure of the detected CTV as well as its dose coverage were used as criteria to evaluate the necessity of correcting any of the target deviations. This strategy, in principle, should be applicable to any type of target deviations, including both target deformable and positional changes and should be independent of how the deviations are detected. The proposed strategy was used on two clinical prostate cancer cases. In both cases, gold markers were implanted inside the prostate for the purpose of treatment setup

  15. Large deviations in boundary-driven systems: Numerical evaluation and effective large-scale behavior

    NASA Astrophysics Data System (ADS)

    Bunin, Guy; Kafri, Yariv; Podolsky, Daniel

    2012-07-01

    We study rare events in systems of diffusive fields driven out of equilibrium by the boundaries. We present a numerical technique and use it to calculate the probabilities of rare events in one and two dimensions. Using this technique, we show that the probability density of a slowly varying configuration can be captured with a small number of long-wavelength modes. For a configuration which varies rapidly in space this description can be complemented by a local-equilibrium assumption.

  16. Experiences from Participants in Large-Scale Group Practice of the Maharishi Transcendental Meditation and TM-Sidhi Programs and Parallel Principles of Quantum Theory, Astrophysics, Quantum Cosmology, and String Theory: Interdisciplinary Qualitative Correspondences

    NASA Astrophysics Data System (ADS)

    Svenson, Eric Johan

    Participants on the Invincible America Assembly in Fairfield, Iowa, and neighboring Maharishi Vedic City, Iowa, practicing Maharishi Transcendental Meditation(TM) (TM) and the TM-Sidhi(TM) programs in large groups, submitted written experiences that they had had during, and in some cases shortly after, their daily practice of the TM and TM-Sidhi programs. Participants were instructed to include in their written experiences only what they observed and to leave out interpretation and analysis. These experiences were then read by the author and compared with principles and phenomena of modern physics, particularly with quantum theory, astrophysics, quantum cosmology, and string theory as well as defining characteristics of higher states of consciousness as described by Maharishi Vedic Science. In all cases, particular principles or phenomena of physics and qualities of higher states of consciousness appeared qualitatively quite similar to the content of the given experience. These experiences are presented in an Appendix, in which the corresponding principles and phenomena of physics are also presented. These physics "commentaries" on the experiences were written largely in layman's terms, without equations, and, in nearly every case, with clear reference to the corresponding sections of the experiences to which a given principle appears to relate. An abundance of similarities were apparent between the subjective experiences during meditation and principles of modern physics. A theoretic framework for understanding these rich similarities may begin with Maharishi's theory of higher states of consciousness provided herein. We conclude that the consistency and richness of detail found in these abundant similarities warrants the further pursuit and development of such a framework.

  17. Effect of stress on energy flux deviation of ultrasonic waves in GR/EP composites

    NASA Technical Reports Server (NTRS)

    Prosser, William H.; Kriz, R. D.; Fitting, Dale W.

    1990-01-01

    Ultrasonic waves suffer energy flux deviation in graphite/epoxy because of the large anisotropy. The angle of deviation is a function of the elastic coefficients. For nonlinear solids, these coefficients and thus the angle of deviation is a function of stress. Acoustoelastic theory was used to model the effect of stress on flux deviation for unidirectional T300/5208 using previously measured elastic coefficients. Computations were made for uniaxial stress along the x3 axis (fiber axis) and the x1 for waves propagating in the x1x3 plane. These results predict a shift as large as three degrees for the quasi-transverse wave. The shift in energy flux offers a new nondestructive technique of evaluating stress in composites.

  18. 14 CFR 21.609 - Approval for deviation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the civil aviation authority in that country to the FAA. ....609 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... deviation. (a) Each manufacturer who requests approval to deviate from any performance standard of a...

  19. The Role of Burden and Deviation in Ostracizing Others.

    PubMed

    Wesselmann, Eric D; Wirth, James H; Pryor, John B; Reeder, Glenn D; Williams, Kipling D

    2015-01-01

    Ostracism (being excluded and ignored) is a painful experience, so why do individuals ostracize others? Previous research suggests individuals often ostracize those who are deviate, but not always. We posit that there may be two types of deviation, burdensome and non-burdensome, and the former is most likely to be ostracized. Study 1 manipulated burdensome deviation by programming a group member to perform more slowly (8 or 16 sec.) than others (4 sec.) in a virtual ball-toss game. Participants perceived slower players as more burdensome and deviate than normal speed players. Additionally, participants ostracized (gave fewer ball tosses to) the slowest player. Study 2 examined participant responses to both burdensome deviation (8- and 16-sec. players) and non-burdensome deviation (goth appearance). Participants again perceived the slower players to be burdensome and deviate, and ostracized them. They perceived the goth player to be deviate but not burdensome and did not ostracize this player. PMID:26267129

  20. 48 CFR 601.470 - Deviations from the DOSAR

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Deviations from the DOSAR 601.470 Section 601.470 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL DEPARTMENT OF STATE ACQUISITION REGULATIONS SYSTEM Deviations from the FAR 601.470 Deviations from the DOSAR...

  1. 48 CFR 2901.403 - Individual deviations from the FAR.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the FAR. 2901.403 Section 2901.403 Federal Acquisition Regulations System DEPARTMENT OF LABOR GENERAL DEPARTMENT OF LABOR ACQUISITION REGULATION SYSTEM Deviations From the FAR and DOLAR 2901.403 Individual deviations from the FAR. (a) The Senior Procurement Executive is authorized to approve deviations from...

  2. 40 CFR 63.1965 - What is a deviation?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... described in 40 CFR 60.758(c)(1) of subpart WWW are exceeded. (b) A deviation occurs when 1 hour or more of... of the landfill monitoring and SSM plan requirements, deviations include the items in paragraphs (a.... (c) A deviation occurs when a SSM plan is not developed or maintained on site....

  3. 40 CFR 63.1965 - What is a deviation?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... described in 40 CFR 60.758(c)(1) of subpart WWW are exceeded. (b) A deviation occurs when 1 hour or more of... of the landfill monitoring and SSM plan requirements, deviations include the items in paragraphs (a.... (c) A deviation occurs when a SSM plan is not developed or maintained on site....

  4. 14 CFR 21.618 - Approval for deviation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... send requests for approval to deviate, together with all pertinent data, through the civil aviation....618 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... deviation. (a) Each manufacturer who requests approval to deviate from any performance standard of a...

  5. 14 CFR 21.618 - Approval for deviation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... send requests for approval to deviate, together with all pertinent data, through the civil aviation....618 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... deviation. (a) Each manufacturer who requests approval to deviate from any performance standard of a...

  6. 14 CFR 21.618 - Approval for deviation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... send requests for approval to deviate, together with all pertinent data, through the civil aviation....618 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... deviation. (a) Each manufacturer who requests approval to deviate from any performance standard of a...

  7. Multidirectional lip-closing force in adults with mandibular deviation.

    PubMed

    Kawabata, A; Kobayashi, T; Takagi, A; Kuroyanagi, F; Washino, K; Sabashi, K; Kitai, N

    2013-09-01

    The purpose of this study was to investigate the relationship between multidi-rectional lip-closing force and facial soft tissue morphology in adults with mandibular deviation. Fifteen Japanese adults with mandibular deviation participated in this study. The deviation value was defined as the horizontal distance between soft tissue menton and the facial midline. The side of the soft tissue menton relative to the facial midline was defined as the deviated side and the opposite side as the non-deviated side. The signals of directional lip-closing force (DLCF) were investigated in 8 directions. Total lip-closing force (TLCF) was calculated by adding DLCFs in 8 directions. Correlations and differences between the variables were analysed statistically. Significant positive correlations between TLCF and DLCFs were determined in six directions with the exception of the horizontal direction. Significant positive correlations for seven pairs of opposing DLCFs were found. The lower non-deviated DLCF was smaller than the three pairs of opposing lip-closing forces. Negative significant correlation was found between the deviation value and the upper deviated DLCF (P < 0·05). In individuals with mandibular deviation, lip-closing force in the lower non-deviated direction was found to be smaller than the opposing lip-closing forces. When mandibular deviation was greater, the upper deviated lip-closing force was smaller. PMID:23855528

  8. 14 CFR 21.609 - Approval for deviation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Approval for deviation. 21.609 Section 21.609 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... deviation. (a) Each manufacturer who requests approval to deviate from any performance standard of a...

  9. Thermodynamic Lower Bounds of Deviation from Instantaneous Canonical State

    NASA Astrophysics Data System (ADS)

    Monnai, Takaaki

    2016-04-01

    We address the issue of the characterization of the nonequilibrium states for the time-dependent processes of a system interacting with a large reservoir, which is initially prepared in an equilibrium state. During the time evolution, we apply an external force to the system so that the actual density matrix is quantitatively different from the canonical state specified by the time-dependent system Hamiltonian. To express how the external forcing causes the deviation from equilibrium, we give a class of thermodynamic expressions for the lower bounds of the distance between the actual nonequilibrium state and the corresponding canonical state. The lower bounds are thermodynamically expressed only in terms of the strength of the forcing and its consequent entropy production rate.

  10. Inspirational airflow patterns in deviated noses: a numerical study.

    PubMed

    Zhu, Jian Hua; Lee, Heow Pueh; Lim, Kian Meng; Lee, Shu Jin; San, Lynette Teo Li; Wang, De Yun

    2013-01-01

    This study attempts to evaluate the effects of deviation of external nose to nasal airflow patterns. Four typical subjects were chosen for model reconstruction based on computed tomography images of undeviated, S-shaped deviated, C-shaped deviated and slanted deviated noses. To study the hypothetical influence of deviation of external nasal wall on nasal airflow (without internal blockage), the collapsed region along the turbinate was artificially reopened in all the three cases with deviated noses. Computational fluid dynamics simulations were carried out in models of undeviated, original deviated and reopened nasal cavities at both flow rates of 167 and 500 ml/s. The shape of the anterior nasal roof was found to be collapsed on one side of the nasal airways in all the deviated noses. High wall shear stress region was found around the collapsed anterior nasal roof. The nasal resistances in cavities with deviated noses were considerably larger than healthy nasal cavity. Patterns of path-line distribution and wall shear stress distribution were similar between original deviated and reopened models. In conclusion, the deviation of an external nose is associated with the collapse of one anterior nasal roof. The crooked external nose induced a larger nasal resistance compared to the undeviated case, while the internal blockage of the airway along the turbinates further increased it. PMID:22515677

  11. Fighting the curse of dimensionality in first-principles semiclassical calculations: non-local reference states for large number of dimensions.

    PubMed

    Ceotto, Michele; Tantardini, Gian Franco; Aspuru-Guzik, Alán

    2011-12-01

    Semiclassical methods face numerical challenges as the dimensionality of the system increases. In the general context of the theory of differential equations, this is known as the "curse of dimensionality." In the present manuscript, we apply the recently-introduced multi-coherent states semiclassical initial value representation (MC-SC-IVR) approach to extend the applicability of first-principles semiclassical calculations. The proposed strategy involves the use of non-local coherent states with the goal of increasing accuracy in the Fourier transforms, and on the other hand, allows for the selection of peaks of different frequencies. The ability to filter desired peaks is important for analyzing the power spectra of complex systems. The MC-SC-IVR approach allows us to solve a 19-dimensional test system and to resolve on-the-fly the power spectra of the formaldehyde molecule with very few classical trajectories. PMID:22149780

  12. Visible-light absorption and large band-gap bowing of GaN1-xSbx from first principles

    SciTech Connect

    Sheetz, R. Michael; Richter, Ernst; Andriotis, Antonis N.; Lisenkov, Sergey; Pendyala, Chandrashekhar; Sunkara, Mahendra K.; Menon, Madhu

    2011-08-01

    Applicability of the Ga(Sbx)N1-x alloys for practical realization of photoelectrochemical water splitting is investigated using first-principles density functional theory incorporating the local density approximation and generalized gradient approximation plus the Hubbard U parameter formalism. Our calculations reveal that a relatively small concentration of Sb impurities is sufficient to achieve a significant narrowing of the band gap, enabling absorption of visible light. Theoretical results predict that Ga(Sbx)N1-x alloys with 2-eV band gaps straddle the potential window at moderate to low pH values, thus indicating that dilute Ga(Sbx)N1-x alloys could be potential candidates for splitting water under visible light irradiation.

  13. Visible-light absorption and large band-gap bowing of GaN1-xSbx from first principles

    DOE PAGESBeta

    Sheetz, R. Michael; Richter, Ernst; Andriotis, Antonis N.; Lisenkov, Sergey; Pendyala, Chandrashekhar; Sunkara, Mahendra K.; Menon, Madhu

    2011-08-01

    Applicability of the Ga(Sbx)N1-x alloys for practical realization of photoelectrochemical water splitting is investigated using first-principles density functional theory incorporating the local density approximation and generalized gradient approximation plus the Hubbard U parameter formalism. Our calculations reveal that a relatively small concentration of Sb impurities is sufficient to achieve a significant narrowing of the band gap, enabling absorption of visible light. Theoretical results predict that Ga(Sbx)N1-x alloys with 2-eV band gaps straddle the potential window at moderate to low pH values, thus indicating that dilute Ga(Sbx)N1-x alloys could be potential candidates for splitting water under visible light irradiation.

  14. The Idiom Principle Revisited

    ERIC Educational Resources Information Center

    Siyanova-Chanturia, Anna; Martinez, Ron

    2015-01-01

    John Sinclair's Idiom Principle famously posited that most texts are largely composed of multi-word expressions that "constitute single choices" in the mental lexicon. At the time that assertion was made, little actual psycholinguistic evidence existed in support of that holistic, "single choice," view of formulaic language. In…

  15. The gait standard deviation, a single measure of kinematic variability.

    PubMed

    Sangeux, Morgan; Passmore, Elyse; Graham, H Kerr; Tirosh, Oren

    2016-05-01

    Measurement of gait kinematic variability provides relevant clinical information in certain conditions affecting the neuromotor control of movement. In this article, we present a measure of overall gait kinematic variability, GaitSD, based on combination of waveforms' standard deviation. The waveform standard deviation is the common numerator in established indices of variability such as Kadaba's coefficient of multiple correlation or Winter's waveform coefficient of variation. Gait data were collected on typically developing children aged 6-17 years. Large number of strides was captured for each child, average 45 (SD: 11) for kinematics and 19 (SD: 5) for kinetics. We used a bootstrap procedure to determine the precision of GaitSD as a function of the number of strides processed. We compared the within-subject, stride-to-stride, variability with the, between-subject, variability of the normative pattern. Finally, we investigated the correlation between age and gait kinematic, kinetic and spatio-temporal variability. In typically developing children, the relative precision of GaitSD was 10% as soon as 6 strides were captured. As a comparison, spatio-temporal parameters required 30 strides to reach the same relative precision. The ratio stride-to-stride divided by normative pattern variability was smaller in kinematic variables (the smallest for pelvic tilt, 28%) than in kinetic and spatio-temporal variables (the largest for normalised stride length, 95%). GaitSD had a strong, negative correlation with age. We show that gait consistency may stabilise only at, or after, skeletal maturity. PMID:27131201

  16. Constraints on deviations from ΛCDM within Horndeski gravity

    NASA Astrophysics Data System (ADS)

    Bellini, Emilio; Cuesta, Antonio J.; Jimenez, Raul; Verde, Licia

    2016-02-01

    Recent anomalies found in cosmological datasets such as the low multipoles of the Cosmic Microwave Background or the low redshift amplitude and growth of clustering measured by e.g., abundance of galaxy clusters and redshift space distortions in galaxy surveys, have motivated explorations of models beyond standard ΛCDM. Of particular interest are models where general relativity (GR) is modified on large cosmological scales. Here we consider deviations from ΛCDM+GR within the context of Horndeski gravity, which is the most general theory of gravity with second derivatives in the equations of motion. We adopt a parametrization in which the four additional Horndeski functions of time αi(t) are proportional to the cosmological density of dark energy ΩDE(t). Constraints on this extended parameter space using a suite of state-of-the art cosmological observations are presented for the first time. Although the theory is able to accommodate the low multipoles of the Cosmic Microwave Background and the low amplitude of fluctuations from redshift space distortions, we find no significant tension with ΛCDM+GR when performing a global fit to recent cosmological data and thus there is no evidence against ΛCDM+GR from an analysis of the value of the Bayesian evidence ratio of the modified gravity models with respect to ΛCDM, despite introducing extra parameters. The posterior distribution of these extra parameters that we derive return strong constraints on any possible deviations from ΛCDM+GR in the context of Horndeski gravity. We illustrate how our results can be applied to a more general frameworks of modified gravity models.

  17. Staphylococcus aureus vaccines: Deviating from the carol.

    PubMed

    Missiakas, Dominique; Schneewind, Olaf

    2016-08-22

    Staphylococcus aureus, a commensal of the human nasopharynx and skin, also causes invasive disease, most frequently skin and soft tissue infections. Invasive disease caused by drug-resistant strains, designated MRSA (methicillin-resistant S. aureus), is associated with failure of antibiotic therapy and elevated mortality. Here we review polysaccharide-conjugate and subunit vaccines that were designed to prevent S. aureus infection in patients at risk of bacteremia or surgical wound infection but failed to reach their clinical endpoints. We also discuss vaccines with ongoing trials for combinations of polysaccharide-conjugates and subunits. S. aureus colonization and invasive disease are not associated with the development of protective immune responses, which is attributable to a large spectrum of immune evasion factors. Two evasive strategies, assembly of protective fibrin shields via coagulases and protein A-mediated B cell superantigen activity, are discussed as possible vaccine targets. Although correlates for protective immunity are not yet known, opsonophagocytic killing of staphylococci by phagocytic cells offers opportunities to establish such criteria. PMID:27526714

  18. Branching ratio deviations from statistical behavior in core photoionization

    NASA Astrophysics Data System (ADS)

    Di Tommaso, Devis; Decleva, Piero

    2005-08-01

    Accurate calculations of carbon 1s photoionization cross sections have been performed at the density functional level with the B-spline linear combination of atomic orbitals approach. The molecules considered are FCCH, FCCCH3, FCCCN, F2CCH2, CF3COOCH2CH3, and C3H5O. The variation of the branching ratios relative to inequivalent C 1s ionizations have been evaluated from threshold to about 100 eV photoelectron kinetic energy. Large deviations from the statistical ratios are observed at low energies, which remain often significant several tens of eV above threshold. The importance of taking into account core branching ratios for peak deconvolution and quantitative analysis, as well as an additional tool for structural information, is pointed out. Strong shape resonant effects are found to largely cancel in branching ratios. Their nature and variation along the series is analyzed in the framework of excitations into σ* valence orbitals.

  19. [Evolutionary deviations from the universal genetic code in ciliates].

    PubMed

    Lukashenko, N P

    2009-04-01

    The review surveys the information, including the most recent data, on the evolution of genetic code in ciliates, which is among the few codes deviating from the universal one. We discuss the cases of recurrent, independently arising deviations from the assignments of standard codons of polypeptide chain termination in the mitochondrial and nuclear genomes of ciliates and some other protozoans. Possible molecular mechanisms are considered, which underlie deviations from standard termination code to coding glutamine (codon UAA and UAG) and cystein or tryptophane (codon UAG) in the nuclear genome. Critical analysis of the main hypotheses on the evolution of secondary deviations from the universal code in ciliates is presented. PMID:19507697

  20. First principles calculation of a large variation in dielectric tensor through the spin crossover in the CsFe[Cr(CN){sub 6}] Prussian blue analogue

    SciTech Connect

    Middlemiss, Derek S. E-mail: R.J.Deeth@warwick.ac.uk; Deeth, Robert J. E-mail: R.J.Deeth@warwick.ac.uk

    2014-04-14

    The dielectric response of spin-crossover (SCO) materials is a key property facilitating their use in next-generation information processing technologies. Solid state hybrid density functional theory calculations show that the temperature-induced and strongly hysteretic SCO transition in the Cs{sup +}Fe{sup 2+}[Cr{sup 3+}(CN{sup −}){sub 6}] Prussian blue analogue (PBA) is associated with a large change (Δ) in both the static, Δε{sup 0}(HS − LS), and high frequency, Δε{sup ∞}(HS − LS) dielectric constants. The SCO-induced variation in CsFe[Cr(CN){sub 6}] is significantly greater than the experimental Δε values observed previously in other SCO materials. The phonon contribution, Δε{sup phon}(HS − LS), determined within a lattice dynamics approach, dominates over the clamped nuclei term, Δε{sup ∞}(HS − LS), and is in turn dominated by the low-frequency translational motions of Cs{sup +} cations within the cubic voids of the Fe[Cr(CN){sub 6}]{sup −} framework. The Cs{sup +} translational modes couple strongly to the large unit cell volume change occurring through the SCO transition. PBAs and associated metal-organic frameworks emerge as a potentially fruitful class of materials in which to search for SCO transitions associated with large changes in dielectric response and other macroscopic properties.

  1. Nonlinear Elastic Effects on the Energy Flux Deviation of Ultrasonic Waves in GR/EP Composites

    NASA Technical Reports Server (NTRS)

    Prosser, William H.; Kriz, R. D.; Fitting, Dale W.

    1992-01-01

    In isotropic materials, the direction of the energy flux (energy per unit time per unit area) of an ultrasonic plane wave is always along the same direction as the normal to the wave front. In anisotropic materials, however, this is true only along symmetry directions. Along other directions, the energy flux of the wave deviates from the intended direction of propagation. This phenomenon is known as energy flux deviation and is illustrated. The direction of the energy flux is dependent on the elastic coefficients of the material. This effect has been demonstrated in many anisotropic crystalline materials. In transparent quartz crystals, Schlieren photographs have been obtained which allow visualization of the ultrasonic waves and the energy flux deviation. The energy flux deviation in graphite/epoxy (gr/ep) composite materials can be quite large because of their high anisotropy. The flux deviation angle has been calculated for unidirectional gr/ep composites as a function of both fiber orientation and fiber volume content. Experimental measurements have also been made in unidirectional composites. It has been further demonstrated that changes in composite materials which alter the elastic properties such as moisture absorption by the matrix or fiber degradation, can be detected nondestructively by measurements of the energy flux shift. In this research, the effects of nonlinear elasticity on energy flux deviation in unidirectional gr/ep composites were studied. Because of elastic nonlinearity, the angle of the energy flux deviation was shown to be a function of applied stress. This shift in flux deviation was modeled using acoustoelastic theory and the previously measured second and third order elastic stiffness coefficients for T300/5208 gr/ep. Two conditions of applied uniaxial stress were considered. In the first case, the direction of applied uniaxial stress was along the fiber axis (x3) while in the second case it was perpendicular to the fiber axis along the

  2. 33 CFR 164.51 - Deviations from rules: Emergency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Deviations from rules: Emergency. 164.51 Section 164.51 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY...: Emergency. Except for the requirements of § 164.53(b), in an emergency, any person may deviate from any...

  3. 33 CFR 164.51 - Deviations from rules: Emergency.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Deviations from rules: Emergency. 164.51 Section 164.51 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY...: Emergency. Except for the requirements of § 164.53(b), in an emergency, any person may deviate from any...

  4. The Relationship Between Inhibition of Return and Saccade Trajectory Deviations

    ERIC Educational Resources Information Center

    Godijn, Richard; Theeuwes, Jan

    2004-01-01

    After presentation of a peripheral cue, a subsequent saccade to the cued location is delayed (inhibition of return: IOR). Furthermore, saccades typically deviate away from the cued location. The present study examined the relationship between these inhibitory effects. IOR and saccade trajectory deviations were found after central (endogenous) and…

  5. 21 CFR 114.89 - Deviations from scheduled processes.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (CONTINUED) FOOD FOR HUMAN CONSUMPTION ACIDIFIED FOODS Production and Process Controls § 114.89 Deviations from scheduled processes. Whenever any process operation deviates from the scheduled process for any... processor of the acidified food shall either: (a) Fully reprocess that portion of the food by a...

  6. Developmental Dyslexia, Neurolinguistic Theory and Deviations in Brain Morphology.

    ERIC Educational Resources Information Center

    Hynd, George W.; And Others

    1991-01-01

    Reviews computer tomography and magnetic resonance imaging studies examining deviations in brain morphology. Discusses methodological and technical issues. Concludes that dyslexics show variations in specific brain regions. Suggests that neuroimaging procedures appear to provide direct evidence supporting the importance of deviations in normal…

  7. Refraction in Terms of the Deviation of the Light.

    ERIC Educational Resources Information Center

    Goldberg, Fred M.

    1985-01-01

    Discusses refraction in terms of the deviation of light. Points out that in physics courses where very little mathematics is used, it might be more suitable to describe refraction entirely in terms of the deviation, rather than by introducing Snell's law. (DH)

  8. 38 CFR 36.4304 - Deviations; changes of identity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... identity. 36.4304 Section 36.4304 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS... Deviations; changes of identity. A deviation of more than 5 percent between the estimates upon which a... change in the identity of the property upon which the original appraisal was based, will invalidate...

  9. 45 CFR 63.19 - Budget revisions and minor deviations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Budget revisions and minor deviations. 63.19... ADMINISTERED BY THE OFFICE OF THE ASSISTANT SECRETARY FOR PLANNING AND EVALUATION Financial Provisions § 63.19 Budget revisions and minor deviations. Pursuant to § 74.102(d) of this title, paragraphs (b)(3) and...

  10. 33 CFR 164.51 - Deviations from rules: Emergency.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Deviations from rules: Emergency. 164.51 Section 164.51 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY NAVIGATION SAFETY REGULATIONS § 164.51 Deviations from...

  11. 33 CFR 164.51 - Deviations from rules: Emergency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Deviations from rules: Emergency. 164.51 Section 164.51 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY NAVIGATION SAFETY REGULATIONS § 164.51 Deviations from...

  12. 45 CFR 63.19 - Budget revisions and minor deviations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Budget revisions and minor deviations. 63.19 Section 63.19 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION GRANT PROGRAMS... Budget revisions and minor deviations. Pursuant to § 74.102(d) of this title, paragraphs (b)(3) and...

  13. 45 CFR 63.19 - Budget revisions and minor deviations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Budget revisions and minor deviations. 63.19 Section 63.19 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION GRANT PROGRAMS... Budget revisions and minor deviations. Pursuant to § 74.102(d) of this title, paragraphs (b)(3) and...

  14. 45 CFR 63.19 - Budget revisions and minor deviations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Budget revisions and minor deviations. 63.19 Section 63.19 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION GRANT PROGRAMS... Budget revisions and minor deviations. Pursuant to § 74.102(d) of this title, paragraphs (b)(3) and...

  15. 45 CFR 63.19 - Budget revisions and minor deviations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Budget revisions and minor deviations. 63.19 Section 63.19 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION GRANT PROGRAMS... Budget revisions and minor deviations. Pursuant to § 74.102(d) of this title, paragraphs (b)(3) and...

  16. On combination of strict Bayesian principles with model reduction technique or how stochastic model calibration can become feasible for large-scale applications

    NASA Astrophysics Data System (ADS)

    Oladyshkin, S.; Schroeder, P.; Class, H.; Nowak, W.

    2013-12-01

    Predicting underground carbon dioxide (CO2) storage represents a challenging problem in a complex dynamic system. Due to lacking information about reservoir parameters, quantification of uncertainties may become the dominant question in risk assessment. Calibration on past observed data from pilot-scale test injection can improve the predictive power of the involved geological, flow, and transport models. The current work performs history matching to pressure time series from a pilot storage site operated in Europe, maintained during an injection period. Simulation of compressible two-phase flow and transport (CO2/brine) in the considered site is computationally very demanding, requiring about 12 days of CPU time for an individual model run. For that reason, brute-force approaches for calibration are not feasible. In the current work, we explore an advanced framework for history matching based on the arbitrary polynomial chaos expansion (aPC) and strict Bayesian principles. The aPC [1] offers a drastic but accurate stochastic model reduction. Unlike many previous chaos expansions, it can handle arbitrary probability distribution shapes of uncertain parameters, and can therefore handle directly the statistical information appearing during the matching procedure. We capture the dependence of model output on these multipliers with the expansion-based reduced model. In our study we keep the spatial heterogeneity suggested by geophysical methods, but consider uncertainty in the magnitude of permeability trough zone-wise permeability multipliers. Next combined the aPC with Bootstrap filtering (a brute-force but fully accurate Bayesian updating mechanism) in order to perform the matching. In comparison to (Ensemble) Kalman Filters, our method accounts for higher-order statistical moments and for the non-linearity of both the forward model and the inversion, and thus allows a rigorous quantification of calibrated model uncertainty. The usually high computational costs of

  17. Small Atomic Orbital Basis Set First-Principles Quantum Chemical Methods for Large Molecular and Periodic Systems: A Critical Analysis of Error Sources.

    PubMed

    Sure, Rebecca; Brandenburg, Jan Gerit; Grimme, Stefan

    2016-04-01

    In quantum chemical computations the combination of Hartree-Fock or a density functional theory (DFT) approximation with relatively small atomic orbital basis sets of double-zeta quality is still widely used, for example, in the popular B3LYP/6-31G* approach. In this Review, we critically analyze the two main sources of error in such computations, that is, the basis set superposition error on the one hand and the missing London dispersion interactions on the other. We review various strategies to correct those errors and present exemplary calculations on mainly noncovalently bound systems of widely varying size. Energies and geometries of small dimers, large supramolecular complexes, and molecular crystals are covered. We conclude that it is not justified to rely on fortunate error compensation, as the main inconsistencies can be cured by modern correction schemes which clearly outperform the plain mean-field methods. PMID:27308221

  18. Small Atomic Orbital Basis Set First‐Principles Quantum Chemical Methods for Large Molecular and Periodic Systems: A Critical Analysis of Error Sources

    PubMed Central

    Sure, Rebecca; Brandenburg, Jan Gerit

    2015-01-01

    Abstract In quantum chemical computations the combination of Hartree–Fock or a density functional theory (DFT) approximation with relatively small atomic orbital basis sets of double‐zeta quality is still widely used, for example, in the popular B3LYP/6‐31G* approach. In this Review, we critically analyze the two main sources of error in such computations, that is, the basis set superposition error on the one hand and the missing London dispersion interactions on the other. We review various strategies to correct those errors and present exemplary calculations on mainly noncovalently bound systems of widely varying size. Energies and geometries of small dimers, large supramolecular complexes, and molecular crystals are covered. We conclude that it is not justified to rely on fortunate error compensation, as the main inconsistencies can be cured by modern correction schemes which clearly outperform the plain mean‐field methods. PMID:27308221

  19. [The crooked nose: correction of dorsal and caudal septal deviations].

    PubMed

    Foda, H M T

    2010-09-01

    The deviated nose represents a complex cosmetic and functional problem. Septal surgery plays a central role in the successful management of the externally deviated nose. This study included 800 patients seeking rhinoplasty to correct external nasal deviations; 71% of these suffered from variable degrees of nasal obstruction. Septal surgery was necessary in 736 (92%) patients, not only to improve breathing, but also to achieve a straight, symmetric external nose. A graduated surgical approach was adopted to allow correction of the dorsal and caudal deviations of the nasal septum without weakening its structural support to the nasal dorsum or nasal tip. The approach depended on full mobilization of deviated cartilage, followed by straightening of the cartilage and its fixation in the corrected position by using bony splinting grafts through an external rhinoplasty approach. PMID:20809379

  20. Drastic deviations from stoichiometry transfer during pulsed laser deposition

    NASA Astrophysics Data System (ADS)

    Dittrich, Arne; Eberl, Christian; Schlenkrich, Susanne; Schlenkrich, Felix; Döring, Florian; Krebs, Hans-Ulrich

    2016-04-01

    In common, one of the most characteristic properties of pulsed laser deposition is the stoichiometry transfer between target and substrate, which has been used heavily for many complex systems. In this paper we show that it is yet possible to obtain drastic deviations from stoichiometry transfer in a binary system by just varying the fluence during laser deposition. In the W-Cu system, the W concentration of films grown from a composite W60Cu40 target (60 wt% W) was indeed continuously changed over an unprecedented large range of 0-70 wt% W. Close to the deposition threshold, pure Cu films are formed due to the much higher vapor pressure of Cu. At higher laser fluences, more and more W-rich W-Cu alloy samples are obtained, since ion implantation and intermixing processes occur. These alloys can reach W contents even higher than that of the target because of enhanced resputtering and reflection of the lighter Cu atoms at the film surface. Stoichiometric films with 60 wt% of W are only obtained at laser fluences around 2.7 J/cm2, when the strong Cu evaporation from the target and reflection and resputtering effects of Cu at the film surface are in balance.

  1. On Testing the Equivalence Principle with Extragalactic Bursts

    NASA Astrophysics Data System (ADS)

    Nusser, Adi

    2016-04-01

    An interesting test of Einstein’s equivalence principle (EEP) relies on the observed lag in the arrival times of photons emitted from extragalactic transient sources. Attributing the lag between photons of different energies to the gravitational potential of the Milky Way (MW), several authors derive new constraints on deviations from EEP. It is shown here that potential fluctuations from the large-scale structure are at least two orders of magnitude larger than the gravitational potential of the MW. Combined with the larger distances, for sources at redshift z≳ 0.5 the rms of the contribution from these fluctuations exceeds the MW by more than four orders of magnitude. We provide actual constraints for several objects based on a statistical calculation of the large-scale fluctuations in the standard ΛCDM cosmological model.

  2. Relative entropy: Free energy associated with equilibrium fluctuations and nonequilibrium deviations

    NASA Astrophysics Data System (ADS)

    Qian, Hong

    2001-04-01

    Using a one-dimensional macromolecule in aqueous solution as an illustration, we demonstrate that the relative entropy from information theory, ∑kpk ln(pk/p*k), has a natural role in the energetics of equilibrium and nonequilibrium conformational fluctuations of the single molecule. It is identified as the free energy difference associated with a fluctuating density in equilibrium, and is associated with the distribution deviate from the equilibrium in nonequilibrium relaxation. This result can be generalized to any other isothermal macromolecular system using the mathematical theories of large deviations and Markov processes, and at the same time provides the well-known mathematical results with interesting physical interpretations.

  3. Identification of characteristic model-observation deviations for coupled data assimilation

    NASA Astrophysics Data System (ADS)

    Geppert, Gernot; Ament, Felix

    2016-04-01

    Exchange fluxes of water and energy between the land surface and the atmosphere lead to the propagation of errors from one model component to the other. Data assimilation can correct such errors in two ways, either by correcting the observed state directly or by changing the state that caused the exchange fluxes. The land surface, for example, strongly determines the temperature in the atmospheric boundary layer. The assimilation of boundary layer temperature can then correct the model's temperature directly. Or the assimilation of boundary layer temperature can act on the model's land surface state. A coupled data assimilation system should exploit these links and enable the second type of correction across model components. Data assimilation relies on instantaneous deviations between model forecasts and observations. Such instantaneous deviations are often hard to relate to errors in specific model components. Therefore, model verification builds on more sophisticated statistics such as long-term biases, gradients, phase shifts, or conditional differences that yield characteristic differences between model forecasts and observations. Compared to the instantaneous deviations in data assimilation, the characteristic deviations in model verification are more closely linked to errors in specific model components. Consequently, such characteristic deviations can potentially be used for data assimilation across model components where instantaneous deviations are not sufficiently informative. As a first step towards data assimilation with characteristic deviations (here named fingerprints), we use ensembles of simulations with the Icosahedral Non-hydrostatic (ICON) model to identify applicable statistics of observable variables. We run ICON in a large eddy simulation configuration on a small, limited domain and systematically perturb soil and land-surface parameters and states to produce the ensembles. Subsequently, we test statistics of boundary layer observables to

  4. A Note on Standard Deviation and Standard Error

    ERIC Educational Resources Information Center

    Hassani, Hossein; Ghodsi, Mansoureh; Howell, Gareth

    2010-01-01

    Many students confuse the standard deviation and standard error of the mean and are unsure which, if either, to use in presenting data. In this article, we endeavour to address these questions and cover some related ambiguities about these quantities.

  5. Curvatons and inhomogeneous scenarios with deviation from slow-roll

    SciTech Connect

    Matsuda, Tomohiro

    2008-12-15

    The spectral index is studied at the point where scalar fields deviate from slow-roll during inflation. Considering the deviation, which may cause a significant difference in the time derivative of the Hubble parameter and also in the terms in the evolution equation, we show how the deviation affects the spectral index of the curvature perturbations. Considering conventional inflation, curvatons and other inhomogeneous scenarios as mechanisms for generating the cosmological perturbation, we examine whether the spectral index induced by the deviation from the standard slow-roll can explain the spectral index n-1>0 at k = 0.002 Mpc{sup -1} while keeping n-1<0 at a smaller scale.

  6. A hybrid method with deviational particles for spatial inhomogeneous plasma

    NASA Astrophysics Data System (ADS)

    Yan, Bokai

    2016-03-01

    In this work we propose a Hybrid method with Deviational Particles (HDP) for a plasma modeled by the inhomogeneous Vlasov-Poisson-Landau system. We split the distribution into a Maxwellian part evolved by a grid based fluid solver and a deviation part simulated by numerical particles. These particles, named deviational particles, could be both positive and negative. We combine the Monte Carlo method proposed in [31], a Particle in Cell method and a Macro-Micro decomposition method [3] to design an efficient hybrid method. Furthermore, coarse particles are employed to accelerate the simulation. A particle resampling technique on both deviational particles and coarse particles is also investigated and improved. This method is applicable in all regimes and significantly more efficient compared to a PIC-DSMC method near the fluid regime.

  7. Comparison of estimators of standard deviation for hydrologic time series.

    USGS Publications Warehouse

    Tasker, Gary D.; Gilroy, E.J.

    1982-01-01

    Unbiasing factors as a function of serial correlation, rho, and sample size, n for the sample standard deviation of a lag one autoregressive model were generated by random number simulation. Monte Carlo experiments were used to compare the performance of several alternative methods for estimating the standard deviation sigma of a lag one autoregressive model in terms of bias, root mean square error, probability of underestimation, and expected opportunity design loss. -from Authors

  8. Nasal Septal Deviations: A Systematic Review of Classification Systems

    PubMed Central

    Teixeira, Jeffrey; Certal, Victor; Chang, Edward T.; Camacho, Macario

    2016-01-01

    Objective. To systematically review the international literature for internal nasal septal deviation classification systems and summarize them for clinical and research purposes. Data Sources. Four databases (including PubMed/MEDLINE) were systematically searched through December 16, 2015. Methods. Systematic review, adhering to PRISMA. Results. After removal of duplicates, this study screened 952 articles for relevance. A final comprehensive review of 50 articles identified that 15 of these articles met the eligibility criteria. The classification systems defined in these articles included C-shaped, S-shaped, reverse C-shaped, and reverse S-shaped descriptions of the septal deviation in both the cephalocaudal and anteroposterior dimensions. Additional studies reported use of computed tomography and categorized deviation based on predefined locations. Three studies graded the severity of septal deviations based on the amount of deflection. The systems defined in the literature also included an evaluation of nasal septal spurs and perforations. Conclusion. This systematic review ascertained that the majority of the currently published classification systems for internal nasal septal deviations can be summarized by C-shaped or reverse C-shaped, as well as S-shaped or reverse S-shaped deviations in the anteroposterior and cephalocaudal dimensions. For imaging studies, predefined points have been defined along the septum. Common terminology can facilitate future research. PMID:26933510

  9. Design and diagnosis of deviated rod-pumped wells

    SciTech Connect

    Gibbs, S.G. )

    1992-07-01

    Commonly used methods for designing rod-pumping installations presume vertical wells. This paper introduces a wave equation methodology that applies to deviated wells, whether they are deviated intentionally or unintentionally. Restrictions on surface locations and interest in horizontal drilling are increasing the need for deviated wells. Together with long-standing crooked-hole problems, these are promising subjects for further study. This paper describes a predictive method that applies to 3D problems. A well deemed too crooked to pump is studies, and a procedure for designing intentionally deviated wells is presented. The relative friction effects of rod guides are discussed, and the effect of borehole path on power consumption is treated. Deviated wells can be adequately designed with wave equation methods, and highly deviated wells can be produced with rod-pumping equipment when care is taken to control the path of the borehole. This paper should be considered as a progress report because much remains to be learned about the application of this petroleum technology.

  10. Dynamic consequences of electromagnetic pull due to deviations in generator shape

    NASA Astrophysics Data System (ADS)

    Lundström, Niklas L. P.; Aidanpää, Jan-Olov

    2007-03-01

    Results from earlier measurements on hydropower generators have indicated relatively large eccentricities and shape deviations in the rotor and stator. These non-symmetric geometries produce an attraction force between the rotor and the stator, called unbalanced magnetic pull (UMP). The UMP force can produce large vibrations which can be dangerous to the machine. A mathematical model is developed to describe the shapes of the rotor and stator, and the corresponding UMP is obtained through the law of energy conservation. The target of the paper is to analyse the dynamics of a generator due to shape deviations in the rotor and stator. As rotor-model, a balanced Jeffcott rotor is used. A linearization of the UMP indicates the importance of considering the nonlinear effects. The stability of some attractors are analysed and the generator dynamics are further investigated by simulating the basin of attraction. The magnitudes are approximately obtained when the shape deviations become dangerous for the generator. It is concluded which shape deviations that are more dangerous than others. In hydropower generator maintenance the shapes of the rotor and stator are frequently measured. The results from this paper can be used to evaluate such measurements and estimate the stability and robustness by simulations.

  11. Effect of Stress on Energy Flux Deviation of Ultrasonic Waves in Ultrasonic Waves in GR/EP Composites

    NASA Technical Reports Server (NTRS)

    Prosser, William H.; Kriz, R. D.; Fitting, Dale W.

    1990-01-01

    Ultrasonic waves suffer energy flux deviation in graphite/epoxy because of the large anisotropy. The angle of deviation is a function of the elastic coefficients. For nonlinear solids, these coefficients and thus the angle of deviation is a function of stress. Acoustoelastic theory was used to model the effect of stress on flux deviation for unidirectional T300/5208 using previously measured elastic coefficients. Computations were made for uniaxial stress along the x3 axis fiber axis) and the x1 axis for waves propagating in the x1x3 plane. These results predict a shift as large as three degrees for the quasi-transverse wave. The shift in energy flux offers new nondestructive technique of evaluating stress in composites.

  12. Cosolvency and deviations from log-linear solubilization.

    PubMed

    Rubino, J T; Yalkowsky, S H

    1987-06-01

    The solubilities of three nonpolar drugs, phenytoin, diazepam, and benzocaine, have been measured in 14 cosolvent-water binary mixtures. The observed solubilities were examined for deviations from solubilities calculated by the equation log Sm = f log Sc + (1 - f) log Sw, where Sm is the solubility of the drug in the cosolvent-water mixture, Sc is the solubility of the drug in neat cosolvent, f is the volume fraction of cosolvent, and Sw is the solubility of the drug in water. When presented graphically, the patterns of the deviations were similar for all three drugs in mixtures of amphiprotic cosolvents (glycols, polyols, and alcohols) and water as well as nonpolar, aprotic cosolvents (dioxane, triglyme, dimethyl isosorbide) and water. The deviations were positive for phenytoin and benzocaine but negative for diazepam in mixtures of dipolar, aprotic cosolvents (dimethylsulfoxide, dimethylformamide, and dimethylacetamide) and water. The source of the deviations could not consistently be attributed to physical properties of the cosolvent-water mixtures or to alterations in the solute crystal. Similarities between the results of this study and those of previous investigations suggest that changes in the structure of the solvent play a role in the deviations from the expected solubilities. PMID:3509286

  13. The precautionary principle: is it safe.

    PubMed

    Gignon, Maxime; Ganry, Olivier; Jardé, Olivier; Manaouil, Cécile

    2013-06-01

    The precautionary principle is generally acknowledged to be a powerful tool for protecting health but it was originally invoked by policy makers for dealing with environmental issues. In the 1990s, the principle was incorporated into many legislative and regulatory texts in international law. One can consider that the precautionary principle has turned into "precautionism" necessary to prove to the people, taking account of risk in decisions. There is now a risk that these abuses will deprive the principle of its meaning and value. When pushed to its limits, the precautionary principle can even be dangerous when applied to the healthcare field. This is why a critical analysis of the principle is necessary. Through the literature, it sometimes seems to deviate somehow from the essence of the precautionary principle as it is commonly used in relation to health. We believe that educational work is necessary to familiarize professionals, policy makers and public opinion of the precautionary principle and avoid confusion. We propose a critical analysis of the use and misuse of the precautionary principle. PMID:23984492

  14. Base station prehospital care: judgement errors and deviations from protocol.

    PubMed

    Wasserberger, J; Ordog, G J; Donoghue, G; Balasubramaniam, S

    1987-08-01

    During a three-year period 5,944 paramedic runs were reviewed at the King/Drew Medical Center for deviations from prehospital management protocols established by the Los Angeles Paramedic Training Institute, and from standard medical practice. An overall compliance to the prehospital management protocols of 94% was found. Compliance to standard medical care was 97%. The most common deviations were failure to administer prophylactic lidocaine to patients having chest pain suggestive of myocardial ischemia and failure to apply cervical spine precautions in patients with suspected head trauma. Fifty percent of the radio operators who deviated from algorithms also were found to be making errors in judgment in standard medical care. PMID:3619166

  15. Deviation from Curie-Weiss behavior in relaxor ferroelectrics

    NASA Astrophysics Data System (ADS)

    Viehland, Dwight; Jang, S. J.; Cross, L. Eric; Wuttig, Manfred

    1992-10-01

    The deviation from Cure-Weiss behavior has been investigated in lead magnesium niobate relaxor ferroelectrics. At high temperatures, the susceptibility was found to follow the Curie-Weiss relationship. A Curie constant and temperature of 1.2×105 and 398 K, respectively, were obtained. With decreasing temperature the deviation was found to increase. It is proposed that this deviation arises due to short-range correlations between polar regions, and that these correlations at high temperatures are the precursor to a freezing of the polarization fluctuations into a glassy state. A local (glassy) order parameter was calculated from the susceptibility by analogy to spin glasses [D. Sherrington and S. Kirkpatrick, Phys. Rev. Lett. 35, 1972 (1975)]. These results are compared to the rms polarization [G. Burns and F. Dacol, Solid State Commun. 48, 853 (1983)] and to the measured remanent polarization. The frequency and field dependence has also been investigated.

  16. High septal osteotomy in rhinoplasty for the deviated nose.

    PubMed

    Jameson, John J; Perry, Adam D; Ritter, Edmond F

    2006-01-01

    When attempting to straighten a patient's healed, deviated bony nasal dorsum, deviation of the central structure (high dorsal septum and medial nasal bones) must be addressed following the completion of medial and lateral osteotomies. When hump resection is not performed, blunt fracture (digitally or with forceps) of the deviated central structure is not a reliable method of mobilization, often leading to postoperative nasal drift. An intranasal osteotomy technique to mobilize the central structure of the nose is described, called "high septal osteotomy." Review of 25 cases suggests high septal osteotomy, supplemented as needed by resection of overlapping septal elements, can be performed safely and efficaciously, permitting stable midline reduction of the nasal pyramid. The technique is not advocated when hump resection is performed, as it is unnecessary and could destabilize the dorsum. Even aggressive maneuvers to mobilize the bony dorsum may fail if not performed properly with meticulous attention to completion of all osteotomies. PMID:16374094

  17. Gulf Stream model. [which considers surface elevation deviations

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Surface elevation deviations in the Gulf Stream region off the eastern coast of the United States between Wallops Island, Virginia and Miami, Florida were investigated. The main causes of surface elevation deviations are geoid perturbations due to the continental shelf and the geostrophic adjustment of the density field due to the Gulf Stream. Quantitative surface elevation profiles were calculated based on geophysical measurements of gravity anomalies and hydrographic data. The results are presented graphically along with contemporaneous weather data. Comparisons are made between the profiles based on hydrographic data and a mean theoretical model. The theory of geostrophic flows including some classical Gulf Stream models is also presented briefly.

  18. [Deviation index of eye and mouth on peripheral facial paralysis].

    PubMed

    Li, Xue; Liao, Pin-Dong; Luo, Min; Zhu, Bin-Ye

    2011-09-01

    Differences of some points, levels and angles of the healthy and affected sides of patients with peripheral facial paralysis were picked out according to photographs. Through analysis of the index between the healthy and affected side of the patients and the difference between healthy people and patients, it is approved that those special points, levels and angles, which are called as deviation index of eye and mouth, can evaluate peripheral facial paralysis objectively and judge the degree of deviation. Therefore, it provides references for the diagnosis of facial paralysis and its degree judgement. PMID:21972641

  19. Equivalence principles and electromagnetism

    NASA Technical Reports Server (NTRS)

    Ni, W.-T.

    1977-01-01

    The implications of the weak equivalence principles are investigated in detail for electromagnetic systems in a general framework. In particular, it is shown that the universality of free-fall trajectories (Galileo weak equivalence principle) does not imply the validity of the Einstein equivalence principle. However, the Galileo principle plus the universality of free-fall rotation states does imply the Einstein principle.

  20. Bioreactor principles

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Cells cultured on Earth (left) typically settle quickly on the bottom of culture vessels due to gravity. In microgravity (right), cells remain suspended and aggregate to form three-dimensional tissue. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators.

  1. Strong deviations from jellium behavior in the valence electron dynamics of potassium

    NASA Astrophysics Data System (ADS)

    Huotari, Simo; Sternemann, Christian; Troparevsky, M. Claudia; Eguiluz, Adolfo G.; Volmer, Martin; Sternemann, Henning; Müller, Harald; Monaco, Giulio; Schülke, Winfried

    2009-10-01

    We present experimental and ab initio theoretical determination of the dynamics of valence electrons in potassium by investigating the dynamical structure factor at nonvanishing momentum transfers. The spectra show large deviations from a jellium-type behavior due to the presence of d -type states above the Fermi level. In particular, we identify two well-defined interband excitations that have a direct correspondence with the density of states above the Fermi level.

  2. Velocity Structure Determination Through Seismic Waveform Modeling and Time Deviations

    NASA Astrophysics Data System (ADS)

    Savage, B.; Zhu, L.; Tan, Y.; Helmberger, D. V.

    2001-12-01

    Through the use of seismic waveforms recorded by TriNet, a dataset of earthquake focal mechanisms and deviations (time shifts) relative to a standard model facilitates the investigation of the crust and uppermost mantle of southern California. The CAP method of focal mechanism determination, in use by TriNet on a routine basis, provides time shifts for surface waves and Pnl arrivals independently relative to the reference model. These shifts serve as initial data for calibration of local and regional seismic paths. Time shifts from the CAP method are derived by splitting the Pnl section of the waveform, the first arriving Pn to just before the arrival of the S wave, from the much slower surface waves then cross-correlating the data with synthetic waveforms computed from a standard model. Surface waves interact with the entire crust, but the upper crust causes the greatest effect. Whereas, Pnl arrivals sample the deeper crust, upper mantle, and source region. This natural division separates the upper from lower crust for regional calibration and structural modeling and allows 3-D velocity maps to be created using the resulting time shifts. Further examination of Pnl and other arrivals which interact with the Moho illuminate the complex nature of this boundary. Initial attempts at using the first 10 seconds of the Pnl section to determine upper most mantle structure have proven insightful. Two large earthquakes north of southern California in Nevada and Mammoth Lakes, CA allow the creation of record sections from 200 to 600 km. As the paths swing from east to west across southern California, simple 1-D models turn into complex structure, dramatically changing the waveform character. Using finite difference models to explain the structure, we determine that a low velocity zone is present at the base of the crust and extends to 100 km in depth. Velocity variations of 5 percent of the mantle in combination with steeply sloping edges produces complex waveform variations

  3. Fast Hough transform analysis: pattern deviation from line segment

    NASA Astrophysics Data System (ADS)

    Ershov, E.; Terekhin, A.; Nikolaev, D.; Postnikov, V.; Karpenko, S.

    2015-12-01

    In this paper, we analyze properties of dyadic patterns. These pattern were proposed to approximate line segments in the fast Hough transform (FHT). Initially, these patterns only had recursive computational scheme. We provide simple closed form expression for calculating point coordinates and their deviation from corresponding ideal lines.

  4. 33 CFR 161.5 - Deviations from the rules.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Deviations from the rules. 161.5 Section 161.5 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY VESSEL TRAFFIC MANAGEMENT Vessel Traffic Services General Rules §...

  5. 49 CFR 110.120 - Deviation from this part.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Deviation from this part. 110.120 Section 110.120 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS AND OIL TRANSPORTATION HAZARDOUS MATERIALS PUBLIC SECTOR TRAINING AND PLANNING...

  6. 24. DETAIL VIEW OF COLUMN #072 DEVIATING FROM VERTICAL IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. DETAIL VIEW OF COLUMN #072 DEVIATING FROM VERTICAL IN ROW OF INTACT COLUMNS, LOOKING NORTHEAST TO SOUTHWEST. (NOTE BOLTED BLOCK SCABBED TO COLUMN AS JOIST/TRUSS SUPPORT) - Oakland Army Base, Transit Shed, East of Dunkirk Street & South of Burma Road, Oakland, Alameda County, CA

  7. 40 CFR 63.1965 - What is a deviation?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 12 2010-07-01 2010-07-01 true What is a deviation? 63.1965 Section 63.1965 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for Hazardous Air Pollutants:...

  8. 40 CFR 63.1965 - What is a deviation?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 13 2014-07-01 2014-07-01 false What is a deviation? 63.1965 Section 63.1965 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air...

  9. 40 CFR 63.1965 - What is a deviation?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true What is a deviation? 63.1965 Section 63.1965 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for Hazardous Air Pollutants:...

  10. 21 CFR 211.100 - Written procedures; deviations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... production and process control designed to assure that the drug products have the identity, strength, quality... approved by the appropriate organizational units and reviewed and approved by the quality control unit. (b... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Written procedures; deviations. 211.100...

  11. Identifying specific erotic cues in sexual deviations by audiotaped descriptions.

    PubMed Central

    Abel, G G; Blanchard, E B; Barlow, D H; Mavissakalian, M

    1975-01-01

    Using audiotaped descriptions of sexual experiences and a direct measure of penile erection, it is possible to specify more precisely erotic cues in sexual deviates. Results indicated that such cues are highly idiosyncratic. Some tentative conclusions and suggested application for the method are discussed. PMID:1184490

  12. 21 CFR 211.100 - Written procedures; deviations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 4 2011-04-01 2011-04-01 false Written procedures; deviations. 211.100 Section 211.100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Production...

  13. 21 CFR 211.100 - Written procedures; deviations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 4 2012-04-01 2012-04-01 false Written procedures; deviations. 211.100 Section 211.100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Production...

  14. 21 CFR 211.100 - Written procedures; deviations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 4 2013-04-01 2013-04-01 false Written procedures; deviations. 211.100 Section 211.100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Production...

  15. 21 CFR 211.100 - Written procedures; deviations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 4 2014-04-01 2014-04-01 false Written procedures; deviations. 211.100 Section 211.100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Production...

  16. 48 CFR 225.1070 - Clause deviations in overseas contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Clause deviations in overseas contracts. 225.1070 Section 225.1070 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Additional...

  17. 48 CFR 225.1070 - Clause deviations in overseas contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Clause deviations in overseas contracts. 225.1070 Section 225.1070 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Additional...

  18. 48 CFR 225.1070 - Clause deviations in overseas contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Clause deviations in overseas contracts. 225.1070 Section 225.1070 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Additional...

  19. 48 CFR 225.1070 - Clause deviations in overseas contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Clause deviations in overseas contracts. 225.1070 Section 225.1070 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Additional...

  20. 48 CFR 225.1070 - Clause deviations in overseas contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Clause deviations in overseas contracts. 225.1070 Section 225.1070 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Additional...

  1. Effects of Simulated Marker Placement Deviations on Running Kinematics and Evaluation of a Morphometric-Based Placement Feedback Method.

    PubMed

    Osis, Sean T; Hettinga, Blayne A; Macdonald, Shari; Ferber, Reed

    2016-01-01

    In order to provide effective test-retest and pooling of information from clinical gait analyses, it is critical to ensure that the data produced are as reliable as possible. Furthermore, it has been shown that anatomical marker placement is the largest source of inter-examiner variance in gait analyses. However, the effects of specific, known deviations in marker placement on calculated kinematic variables are unclear, and there is currently no mechanism to provide location-based feedback regarding placement consistency. The current study addresses these disparities by: applying a simulation of marker placement deviations to a large (n = 411) database of runners; evaluating a recently published method of morphometric-based deviation detection; and pilot-testing a system of location-based feedback for marker placements. Anatomical markers from a standing neutral trial were moved virtually by up to 30 mm to simulate deviations. Kinematic variables during running were then calculated using the original, and altered static trials. Results indicate that transverse plane angles at the knee and ankle are most sensitive to deviations in marker placement (7.59 degrees of change for every 10 mm of marker error), followed by frontal plane knee angles (5.17 degrees for every 10 mm). Evaluation of the deviation detection method demonstrated accuracies of up to 82% in classifying placements as deviant. Finally, pilot testing of a new methodology for providing location-based feedback demonstrated reductions of up to 80% in the deviation of outcome kinematics. PMID:26765846

  2. Follicle and endocrine dynamics during experimental follicle deviation in mares.

    PubMed

    Ginther, O J; Meira, C; Beg, M A; Bergfelt, D R

    2002-09-01

    Deviation during a follicular wave in mares begins when the largest follicle (F1) reaches a mean diameter of 22.5 mm and is characterized by continued growth of F1 to become the dominant follicle and regression of F2 to become the largest subordinate follicle. In the present study, F1 was ablated at the expected beginning of deviation (Hour 0) to provide a reference point for characterizing the intrafollicular changes preceding experimental deviation between F2 and F3. Diameters and concentrations of follicular fluid factors in F2 and F3 were determined in F1-ablated mares at Hours 0, 12, 24, 48, or 72 (n = 8 mares/group). Circulating FSH concentrations were greater (P < 0.05) in the Hour 72 ablation group than in controls 12 h after ablation and then progressively decreased. The diameters of F2 and F3 increased (P < 0.05) during Hours 0 to 24. Thereafter, F2 continued to increase but F3 did not, indicating that experimental deviation began at Hour 24. The diameter of F2 and circulating FSH concentration at Hour 24 were similar (P > 0.1) to the diameter of F1 and FSH concentration at Hour 0, respectively. A differential change between F2 and F3 was not detected in follicular fluid concentrations of estradiol, inhibin-A, and activin-A by the beginning of experimental deviation. However, estradiol was higher in F2 at Hours 0 and 12 and inhibin-A was higher in F2 throughout the experiment, and both factors could have been involved in experimental deviation. Free insulin-like growth factor-1 (IGF-1) increased (P < 0.05) in F2 beginning at Hour 12 and was higher (P < 0.05) in F2 than in F3 by the beginning of experimental deviation. Temporally, this result indicated that intrafollicular IGF-1 was involved in conversion of F2 from a destined subordinate follicle to a dominant follicle. PMID:12193395

  3. "C.R.E.A.T.E."-ing Unique Primary-Source Research Paper Assignments for a Pleasure and Pain Course Teaching Neuroscientific Principles in a Large General Education Undergraduate Course.

    PubMed

    Bodnar, Richard J; Rotella, Francis M; Loiacono, Ilyssa; Coke, Tricia; Olsson, Kerstin; Barrientos, Alicia; Blachorsky, Lauren; Warshaw, Deena; Buras, Agata; Sanchez, Ciara M; Azad, Raihana; Stellar, James R

    2016-01-01

    A large (250 registrants) General Education lecture course, Pleasure and Pain, presented basic neuroscience principles as they related to animal and human models of pleasure and pain by weaving basic findings related to food and drug addiction and analgesic states with human studies examining empathy, social neuroscience and neuroeconomics. In its first four years, the course grade was based on weighted scores from two multiple-choice exams and a five-page review of three unique peer-reviewed research articles. Although well-registered and well-received, 18% of the students received Incomplete grades, primarily due to failing to submit the paper that went largely unresolved and eventually resulted in a failing grade. To rectify this issue, a modified version of the C.R.E.A.T.E. (Consider, Read, Elucidate hypotheses, Analyze and interpret data, Think of the next Experiment) method replaced the paper with eight structured assignments focusing on an initial general-topic article, the introduction-methods, and results-discussion of each of three related peer-review neuroscience-related articles, and a final summary. Compliance in completing these assignments was very high, resulting in only 11 INC grades out of 228 students. Thus, use of the C.R.E.A.T.E. method reduced the percentage of problematic INC grades from 18% to 4.8%, a 73% decline, without changing the overall grade distribution. Other analyses suggested the students achieved a deeper understanding of the scientific process using the C.R.E.A.T.E. method relative to the original term paper assignment. PMID:27385918

  4. “C.R.E.A.T.E.”-ing Unique Primary-Source Research Paper Assignments for a Pleasure and Pain Course Teaching Neuroscientific Principles in a Large General Education Undergraduate Course

    PubMed Central

    Bodnar, Richard J.; Rotella, Francis M.; Loiacono, Ilyssa; Coke, Tricia; Olsson, Kerstin; Barrientos, Alicia; Blachorsky, Lauren; Warshaw, Deena; Buras, Agata; Sanchez, Ciara M.; Azad, Raihana; Stellar, James R.

    2016-01-01

    A large (250 registrants) General Education lecture course, Pleasure and Pain, presented basic neuroscience principles as they related to animal and human models of pleasure and pain by weaving basic findings related to food and drug addiction and analgesic states with human studies examining empathy, social neuroscience and neuroeconomics. In its first four years, the course grade was based on weighted scores from two multiple-choice exams and a five-page review of three unique peer-reviewed research articles. Although well-registered and well-received, 18% of the students received Incomplete grades, primarily due to failing to submit the paper that went largely unresolved and eventually resulted in a failing grade. To rectify this issue, a modified version of the C.R.E.A.T.E. (Consider, Read, Elucidate hypotheses, Analyze and interpret data, Think of the next Experiment) method replaced the paper with eight structured assignments focusing on an initial general-topic article, the introduction-methods, and results-discussion of each of three related peer-review neuroscience-related articles, and a final summary. Compliance in completing these assignments was very high, resulting in only 11 INC grades out of 228 students. Thus, use of the C.R.E.A.T.E. method reduced the percentage of problematic INC grades from 18% to 4.8%, a 73% decline, without changing the overall grade distribution. Other analyses suggested the students achieved a deeper understanding of the scientific process using the C.R.E.A.T.E. method relative to the original term paper assignment. PMID:27385918

  5. Predicting leptonic CP phase by considering deviations in charged lepton and neutrino sectors

    NASA Astrophysics Data System (ADS)

    Sruthilaya, M.; Soumya, C.; Deepthi, K. N.; Mohanta, R.

    2015-08-01

    Recently, the reactor mixing angle {θ }13 has been measured precisely by Daya Bay, RENO, and T2K experiments with a moderately large value. However, the standard form of neutrino mixing patterns such as bimaximal, tri-bimaximal, golden ratio of types A and B, hexagonal, etc., which are based on certain flavor symmetries, predict vanishing {θ }13. Using the fact that the neutrino mixing matrix can be represented as {V}{PMNS}={U}l\\dagger {U}ν {P}ν , where Ul and {U}ν result from the diagonalization of the charged lepton and neutrino mass matrices and {P}ν is a diagonal matrix containing Majorana phases, we explore the possibility of accounting for the large reactor mixing angle by considering deviations both in the charged lepton and neutrino sector. In the charged lepton sector we consider the deviation as an additional rotation in the (12) and (13) planes, whereas in the neutrino sector we consider deviations to various neutrino mixing patterns through (13) and (23) rotations. We find that with the inclusion of these deviations it is possible to accommodate the observed large reactor mixing angle {θ }13, and one can also obtain limits on the charge-conjugation parity-violating Dirac phase{δ }{CP} and Jarlskog invariant JCP for most of the cases. We then explore whether our findings can be tested in the currently running NuMI Off-axis ve Appearance experiment with three years of data taking in neutrino mode followed by three years with the anti-neutrino mode.

  6. Understanding positive and negative deviations in polarity of ionic liquid mixtures by pseudo-solvent approach.

    PubMed

    Beniwal, Vijay; Kumar, Anil

    2016-08-24

    Physico-chemical properties of liquid mixtures in general display large deviations from linear behaviour, arising out of complex specific and non-specific intermolecular interactions. The polarity of liquid mixtures displaying large positive and negative deviations can be minimized and linear mixing can be achieved in liquids using a pseudo-solvent methodology. The work described herein is designed to investigate the influence of different physical parameters on the linear pseudo-solvent composition in ionic liquid mixtures. For this purpose, we have determined the deviations from linearity, ΔE values (defined as given by ) for binary mixtures of a variety of ionic liquids, including two molecular solvents, DMSO and formamide. Firstly, the investigations were carried out in three 1-butyl-3-methylimidazolium cation based aprotic ionic liquids and the roles of anionic structure and hydrogen bond acceptor basicities (β values) of the ionic liquids were determined. The influence of the cationic structure, i.e., the hydrogen bond donor acidity (α values) and non-associative nature of the ionic liquids, was determined using C2-methylated analogs, 1-butyl-2,3-dimethylimidazolium cation based ionic liquids. The role of the protic nature of ionic liquids was studied in two protic ionic liquids, viz., 1-methylimidazolium formate and 1-methylimidazolium acetate. The effects of the temperature, pseudo-solvent structure and solvatochromic probe structure on the ΔE values were also explored. PMID:27523572

  7. First-Principles Momentum-Dependent Local Ansatz Wavefunction and Momentum Distribution Function Bands of Iron

    NASA Astrophysics Data System (ADS)

    Kakehashi, Yoshiro; Chandra, Sumal

    2016-04-01

    We have developed a first-principles local ansatz wavefunction approach with momentum-dependent variational parameters on the basis of the tight-binding LDA+U Hamiltonian. The theory goes beyond the first-principles Gutzwiller approach and quantitatively describes correlated electron systems. Using the theory, we find that the momentum distribution function (MDF) bands of paramagnetic bcc Fe along high-symmetry lines show a large deviation from the Fermi-Dirac function for the d electrons with eg symmetry and yield the momentum-dependent mass enhancement factors. The calculated average mass enhancement m*/m = 1.65 is consistent with low-temperature specific heat data as well as recent angle-resolved photoemission spectroscopy (ARPES) data.

  8. Deviation from the superparamagnetic behaviour of fine-particle systems

    NASA Astrophysics Data System (ADS)

    Mălăescu, I.; Marin, C. N.

    2000-07-01

    Studies concerning superparamagnetic behaviour of fine magnetic particle systems were performed using static and radiofrequency measurements, in the range 1-60 MHz. The samples were: a ferrofluid with magnetite particles dispersed in kerosene (sample A), magnetite powder (sample B) and the same magnetite powder dispersed in a polymer (sample C). Radiofrequency measurements indicated a maximum in the imaginary part of the complex magnetic susceptibility, for each of the samples, at frequencies with the magnitude order of tens of MHz, the origin of which was assigned to Néel-type relaxation processes. The static measurements showed a Langevin-type dependence of magnetisation M and of susceptibility χ, on the magnetic field for sample A. For samples B and C deviations from this type of dependence were found. These deviations were analysed qualitatively and explained in terms of the interparticle interactions, dispersion medium influence and surface effects.

  9. Deviations from Liquidlike Behavior in Molten Polymer Films at Interfaces

    NASA Astrophysics Data System (ADS)

    Seo, Young-Soo; Koga, T.; Sokolov, J.; Rafailovich, M. H.; Tolan, M.; Sinha, S.

    2005-04-01

    We have performed x-ray specular and diffuse scattering on liquid polymer films and analyzed the spectra as a function of film thickness and molecular weight. The results show that films whose molecular weight is close to the entanglement length behave as simple liquids except that the shortest wavelength is determined by the radius of gyration (Rg) rather than the monomer-monomer distance. When the molecular weight is higher than the entanglement length, the strong deviations from liquidlike behavior are observed. We find that the long wavelength cutoff vector, ql,c, scales with film thickness, d as d-1.1±0.1 rather than the usual d-2 expected for simple liquids. If we assume that these deviations are due to surface pinning of the polymer chains, then our results are consistent with the formalism developed by Fredrickson et al. to explain the capillary wave spectrum that can propagate in a polymer brush.

  10. Dissociated vertical deviation-a clinical and laboratory study.

    PubMed Central

    Helveston, E M

    1980-01-01

    The previously reported nomenclature and clinical characteristics of dissociated vertical deviation have been recorded. The incidence and characteristics of DVD have been determined by evaluation of 1,000 consecutive strabismus or nystagmus patients, and with selected chart study carried out on the 111 DVD patients found in this series. Electro-oculographic studies of selected patients with DVD provided objective evidence of the speed and amplitude of the ocular movements in DVD. Bell phenomenon, strabismus sursoadductorius and the Bielschowsky phenomenon were recorded and compared to clinical findings of strabismus patients with DVD. The technique for the results of surgery for DVD were described. Dissociated vertical deviation was characterized as a component of the overall strabismus picture. Images FIGURE 1 A FIGURE 1 B FIGURE 1 C FIGURE 1 D FIGURE 1 E FIGURE 2 A FIGURE 2 B FIGURE 2 C FIGURE 3 A FIGURE 3 B FIGURE 3 C FIGURE 4 A FIGURE 4 B PMID:7020216

  11. The Laplace method for small deviations of Gaussian processes of Wiener type

    NASA Astrophysics Data System (ADS)

    Fatalov, V. R.

    2005-04-01

    Results on the exact asymptotics of the probabilities \\displaystyle \\mathsf P\\biggl\\{\\,\\int_0^1\\vert\\xi(t)\\vert^p\\,dt \\le\\varepsilon^p\\biggr\\},\\qquad\\varepsilon\\to 0,for p>0 are proved for two Gaussian processes \\xi(t): the Wiener process and the Brownian bridge. The method of study is the Laplace method in Banach spaces and the approach to the probabilities of small deviations based on the theory of large deviations for the occupation time. The calculations are carried out for the cases p=1 and p=2 as a result of solving the extremal problem for the action functional and studying the corresponding Schrödinger equations.

  12. OSMOSIS: A CAUSE OF APPARENT DEVIATIONS FROM DARCY'S LAW.

    USGS Publications Warehouse

    Olsen, Harold W.

    1985-01-01

    This review of the existing evidence shows that osmosis causes intercepts in flow rate versus hydraulic gradient relationships that are consistent with the observed deviations from Darcy's law at very low gradients. Moreover, it is suggested that a natural cause of osmosis in laboratory samples could be chemical reactions such as those involved in aging effects. This hypothesis is analogous to the previously proposed occurrence of electroosmosis in nature generated by geochemical weathering reactions. Refs.

  13. Geometric deviation modeling by kinematic matrix based on Lagrangian coordinate

    NASA Astrophysics Data System (ADS)

    Liu, Weidong; Hu, Yueming; Liu, Yu; Dai, Wanyi

    2015-09-01

    Typical representation of dimension and geometric accuracy is limited to the self-representation of dimension and geometric deviation based on geometry variation thinking, yet the interactivity affection of geometric variation and gesture variation of multi-rigid body is not included. In this paper, a kinematic matrix model based on Lagrangian coordinate is introduced, with the purpose of unified model for geometric variation and gesture variation and their interactive and integrated analysis. Kinematic model with joint, local base and movable base is built. The ideal feature of functional geometry is treated as the base body; the fitting feature of functional geometry is treated as the adjacent movable body; the local base of the kinematic model is fixed onto the ideal geometry, and the movable base of the kinematic model is fixed onto the fitting geometry. Furthermore, the geometric deviation is treated as relative location or rotation variation between the movable base and the local base, and it's expressed by the Lagrangian coordinate. Moreover, kinematic matrix based on Lagrangian coordinate for different types of geometry tolerance zones is constructed, and total freedom for each kinematic model is discussed. Finally, the Lagrangian coordinate library, kinematic matrix library for geometric deviation modeling is illustrated, and an example of block and piston fits is introduced. Dimension and geometric tolerances of the shaft and hole fitting feature are constructed by kinematic matrix and Lagrangian coordinate, and the results indicate that the proposed kinematic matrix is capable and robust in dimension and geometric tolerances modeling.

  14. Quantifying prosthetic gait deviation using simple outcome measures

    PubMed Central

    Kark, Lauren; Odell, Ross; McIntosh, Andrew S; Simmons, Anne

    2016-01-01

    AIM: To develop a subset of simple outcome measures to quantify prosthetic gait deviation without needing three-dimensional gait analysis (3DGA). METHODS: Eight unilateral, transfemoral amputees and 12 unilateral, transtibial amputees were recruited. Twenty-eight able-bodied controls were recruited. All participants underwent 3DGA, the timed-up-and-go test and the six-minute walk test (6MWT). The lower-limb amputees also completed the Prosthesis Evaluation Questionnaire. Results from 3DGA were summarised using the gait deviation index (GDI), which was subsequently regressed, using stepwise regression, against the other measures. RESULTS: Step-length (SL), self-selected walking speed (SSWS) and the distance walked during the 6MWT (6MWD) were significantly correlated with GDI. The 6MWD was the strongest, single predictor of the GDI, followed by SL and SSWS. The predictive ability of the regression equations were improved following inclusion of self-report data related to mobility and prosthetic utility. CONCLUSION: This study offers a practicable alternative to quantifying kinematic deviation without the need to conduct complete 3DGA. PMID:27335814

  15. Deviated nasal septum hinders intranasal sprays: A computer simulation study

    PubMed Central

    Frank, Dennis O.; Kimbell, Julia S.; Cannon, Daniel; Pawar, Sachin S.; Rhee, John S.

    2013-01-01

    Background This study investigates how deviated nasal septum affects the quantity and distribution of spray particles, and examines the effects of inspiratory airflow and head position on particle transport. Methods Deposition of spray particles was analysed using a three-dimensional computational fluid dynamics model created from a computed tomography scan of a human nose with leftward septal deviation and a right inferior turbinate hypertrophy. Five simulations were conducted using Fluent™ software, with particle sizes ranging from 20-110μm, a spray speed of 3m/s, plume angle of 68°, and with steady state inspiratory airflow either present (15.7L/min) or absent at varying head positions. Results With inspiratory airflow present, posterior deposition on the obstructed side was approximately four times less than the contralateral side, regardless of head position, and was statistically significant (p<0.05). When airflow was absent, predicted deposition beyond the nasal valve on the left and right sides were between 16% and 69% lower and positively influenced by a dependent head position. Conclusions Simulations predicted that septal deviation significantly diminished drug delivery on the obstructed side. Furthermore, increased particle penetration was associated with presence of nasal airflow. Head position is an important factor in particle deposition patterns when inspiratory airflow is absent. PMID:22888490

  16. Lateral and axial resolutions of an angle-deviation microscope for different numerical apertures: experimental results

    NASA Astrophysics Data System (ADS)

    Chiu, Ming-Hung; Lai, Chin-Fa; Tan, Chen-Tai; Lin, Yi-Zhi

    2011-03-01

    This paper presents a study of the lateral and axial resolutions of a transmission laser-scanning angle-deviation microscope (TADM) with different numerical aperture (NA) values. The TADM is based on geometric optics and surface plasmon resonance principles. The surface height is proportional to the phase difference between two marginal rays of the test beam, which is passed through the test medium. We used common-path heterodyne interferometry to measure the phase difference in real time, and used a personal computer to calculate and plot the surface profile. The experimental results showed that the best lateral and axial resolutions for NA = 0.41 were 0.5 μm and 3 nm, respectively, and the lateral resolution breaks through the diffraction limits.

  17. Determining Statistically Significant Deviations from a Model Crater Production Function for Estimating Resurfacing Events

    NASA Astrophysics Data System (ADS)

    Weaver, B. P.; Hilbe, J. M.; Robbins, S. J.; Plesko, C. S.; Riggs, J. D.

    2015-05-01

    Many crater analysts will search for deviations of observed crater population data from model crater populations and treat those deviations as a modification event - usually resurfacing. We will discuss how to assign confidences for these deviations.

  18. A gait index may underestimate changes of gait: a comparison of the Movement Deviation Profile and the Gait Deviation Index.

    PubMed

    Barton, Gabor J; Hawken, Malcolm B; Holmes, Gill; Schwartz, Michael H

    2015-01-01

    The ability of the Movement Deviation Profile (MDP) and Gait Deviation Index (GDI) to detect gait changes was compared in a child with cerebral palsy who underwent game training. Conventional gait analysis showed that sagittal plane angles became mirrored about normality after training. Despite considerable gait changes, the GDI showed minimal change, while the MDP detected a difference equal to a shift between 10-9 on the Functional Assessment Questionnaire scale. Responses of the GDI and MDP were examined during a synthetic transition of the patient's curves from before intervention to a state mirrored about normality. The GDI showed a symmetric response on the two opposite sides of normality but the neural network based MDP gave an asymmetric response reflecting faithfully the unequal biomechanical consequences of joint angle changes. In conclusion, the MDP can detect altered gait even if the changes are missed by the GDI. PMID:23521124

  19. Analysis and interpretation of stress indicators in deviated wells of the Coso Geothermal Field

    NASA Astrophysics Data System (ADS)

    Schoenball, Martin; Glen, Jonathan M. G.; Davatzes, Nicholas C.

    2016-04-01

    Characterizing the tectonic stress field is an integral part for the development of hydrothermal systems, especially enhanced geothermal systems (EGS). With a known stress field, critically stressed faults can be identified. Faults that are critically oriented with respect to the in-situ stress field exhibit a high tendency for slip, and thus are likely candidates for reactivation during the creation of an EGS. Reactivated faults are known to serve as dominant fluid pathways during hydrothermal circulation and the characteristics of this process determine the potential for damaging earthquakes; should extensive portions of well-oriented, large features be reactivated. As part of the FORGE initiative at the West Flank of the Coso Geothermal Field, we analyze a large set of image logs obtained from wells distributed across the geothermal field for details about the stress state revealed by indicators such as borehole breakouts and drilling-induced tensile fractures. Previous stress analyses at Coso have ignored deviated well sections, since their interpretation for the orientation of the stress tensor is non-unique with respect to varying stress magnitudes. Using interpreted borehole-induced structures, we perform a grid search over all possible Andersonian stress states and find a best fitting vertical stress tensor for each stress state characterized by principal stress magnitudes. By including deviated well sections and recently drilled wells, we considerably expand the suite of stress measurements in the Coso Geothermal Field. Along individual wells, this analysis also reveals local meter length-scale deviations from the best-fitting mean stress orientation. While most wells show consistent horizontal principal stress orientations with standard deviations of about 10°, other wells show large standard deviations on the order of 25°. Several regions have logged well trajectories with lateral spacing below 1 km. This enables us to trace changes of the stress

  20. A model of curved saccade trajectories: spike rate adaptation in the brainstem as the cause of deviation away.

    PubMed

    Kruijne, Wouter; Van der Stigchel, Stefan; Meeter, Martijn

    2014-03-01

    The trajectory of saccades to a target is often affected whenever there is a distractor in the visual field. Distractors can cause a saccade to deviate towards their location or away from it. The oculomotor mechanisms that produce deviation towards distractors have been thoroughly explored in behavioral, neurophysiological and computational studies. The mechanisms underlying deviation away, on the other hand, remain unclear. Behavioral findings suggest a mechanism of spatially focused, top-down inhibition in a saccade map, and deviation away has become a tool to investigate such inhibition. However, this inhibition hypothesis has little neuroanatomical or neurophysiological support, and recent findings go against it. Here, we propose that deviation away results from an unbalanced saccade drive from the brainstem, caused by spike rate adaptation in brainstem long-lead burst neurons. Adaptation to stimulation in the direction of the distractor results in an unbalanced drive away from it. An existing model of the saccade system was extended with this theory. The resulting model simulates a wide range of findings on saccade trajectories, including findings that have classically been interpreted to support inhibition views. Furthermore, the model replicated the effect of saccade latency on deviation away, but predicted this effect would be absent with large (400 ms) distractor-target onset asynchrony. This prediction was confirmed in an experiment, which demonstrates that the theory both explains classical findings on saccade trajectories and predicts new findings. PMID:24486387

  1. Teaching Standard Deviation by Building from Student Invention

    ERIC Educational Resources Information Center

    Day, James; Nakahara, Hiroko; Bonn, Doug

    2010-01-01

    First-year physics laboratories are often driven by a mix of goals that includes the illustration or discovery of basic physics principles and a myriad of technical skills involving specific equipment, data analysis, and report writing. The sheer number of such goals seems guaranteed to produce cognitive overload, even when highly detailed…

  2. Deviation from Gaussian behavior in the self-correlation function of the proton motion in polybutadiene

    NASA Astrophysics Data System (ADS)

    Zorn, R.

    1997-03-01

    In this article neutron-scattering experiments using the backscattering instrument IN13 on the glass-forming polymer polybutadiene are reported. As compared to other neutron spectrometers IN13 has a large range of wave vectors Q accessible. Therefore, a better statement can be made about the spatial extent of the observed motions. In order to obtain reliable results for the Q dependence a multiple scattering correction of the intensities has been performed. The Q dependence of the incoherent scattering from polybutadiene shows strong deviations from the Gaussian approximation at high Q. These deviations are interpreted under different microscopical model assumptions. Finally, a picture of a distribution of anharmonic potentials can give account for the observed deviation from Gaussian behavior in the incoherent intermediate scattering function at low temperatures. At higher temperatures the fast motion in these potentials is superimposed by a long-range diffusional motion. The latter may be extracted assuming a model for the fast motion. It shows certain characteristics of fractal diffusion but defies a simple scaling approach.

  3. Quality Assessment of Vertical Angular Deviations for Photometer Calibration Benches

    NASA Astrophysics Data System (ADS)

    Silva Ribeiro, A.; Costa Santos, A.; Alves Sousa, J.; Forbes, A. B.

    2015-02-01

    Lighting, both natural and electric, constitutes one of the most important aspects of the life of human beings, allowing us to see and perform our daily tasks in outdoor and indoor environments. The safety aspects of lighting are self-evident in areas such as road lighting, urban lighting and also indoor lighting. The use of photometers to measure lighting levels requires traceability obtained in accredited laboratories, which must provide an associated uncertainty. It is therefore relevant to study the impact of known uncertainty sources like the vertical angular deviation of photometer calibration benches, in order to define criteria to its quality assessment.

  4. How the “main condition” of phase stability can explain the effect of the velocity deviation of secondary electrons in DC-biased single-sided multipactors

    SciTech Connect

    Mostajeran, M.

    2014-11-15

    In this work, a “main condition” for phase stability has been employed to investigate the effects of the velocity deviation of the electrons in DC-biased single-sided multipactors (MPs). In a previous study [M. Mostajeran, Phys. Plasmas 21, 053108 (2014)], a stability equation was derived, where the secondary electron was assumed to have zero initial velocity and the phase deviation from the resonant phase was considered. In this work, both deviations in phase and velocity from the resonant condition are taken into account, assuming nonzero initial velocity for the secondary electrons. Using the main condition for stability, it is shown that MP discharge can rise in situations, where large velocity deviations from initial velocity and large phase deviations from resonant phase exist. This is contrary to what can be predicted on the basis of the “simple stability condition.” This result is further confirmed by numerical simulations.

  5. Fast and slow flexural waves in a deviated borehole in homogeneous and layered anisotropic formations

    NASA Astrophysics Data System (ADS)

    He, Xiao; Hu, Hengshan; Guan, Wei

    2010-04-01

    Dipole acoustic fields in an arbitrarily deviated well penetrating a homogeneous as well as a stratified transversely isotropic formation are simulated using a 3-D finite-difference time-domain algorithm in cylindrical coordinates. The modelling results show that a dipole source can excite a fast- and a slow-flexural mode due to the shear wave anisotropy when the borehole is inclined with respect to the symmetry axis of transverse isotropy. Both flexural slownesses change with the wellbore deviation angle. The splitting of flexural modes is prominent in full wave arrays when the shear anisotropy is strong enough. It is revealed that the dipole orientation influences the relative amplitudes of the fast- and slow-flexural waves but it has no effect on their slownesses or phases. In a vertical well parallel to the symmetry axis, the two flexural waves degenerate and propagate at the same speed. The degenerated flexural wave travels approximately at the shear speed along the borehole wall except in a few formations. Our study shows, for example, that it is about 10 per cent slower than the shear wave in Mesaverde clayshale 5501. Even in that kind of formations, however, extraction of the fast- and slow-shear velocities from the flexural modes is still possible if the borehole deviation is large enough. To examine the effect of layering, we modelled the full waves in a formation with a sandwich. When the well is perpendicular to the layer interfaces, reflection is obvious and can be recognized. It becomes weaker or even invisible as the deviation angle increases, so it is difficult to detect a thin layer embedded in a formation directly from reflected waves. The sandwich can, instead, be recognized from the irregularity in the spectra of the full waveforms displayed versus depth. [Correction added after online publication 25th February 2009; the original spelling of `homogenous' in the title has been corrected to `homogeneous'.[

  6. Altitude deviations: Breakdowns of an error-tolerant system

    NASA Technical Reports Server (NTRS)

    Palmer, Everett A.; Hutchins, Edwin L.; Ritter, Richard D.; Vancleemput, Inge

    1993-01-01

    Pilot reports of aviation incidents to the Aviation Safety Reporting System (ASRS) provide a window on the problems occurring in today's airline cockpits. The narratives of 10 pilot reports of errors made in the automation-assisted altitude-change task are used to illustrate some of the issues of pilots interacting with automatic systems. These narratives are then used to construct a description of the cockpit as an information processing system. The analysis concentrates on the error-tolerant properties of the system and on how breakdowns can occasionally occur. An error-tolerant system can detect and correct its internal processing errors. The cockpit system consists of two or three pilots supported by autoflight, flight-management, and alerting systems. These humans and machines have distributed access to clearance information and perform redundant processing of information. Errors can be detected as deviations from either expected behavior or as deviations from expected information. Breakdowns in this system can occur when the checking and cross-checking tasks that give the system its error-tolerant properties are not performed because of distractions or other task demands. Recommendations based on the analysis for improving the error tolerance of the cockpit system are given.

  7. [Congenital penile deviation: an integral diagnostic approach to correction].

    PubMed

    Koroleva, S V; Kovalev, V A; Burov, V N; Danovich, V M; Leshcheva, N V; Orlova, E V

    2005-01-01

    A comparative analysis of diagnostic examination of 130 men with isolated congenital erectile penile deviation (EPD) aged 14-22 years (mean age 17 years) has demonstrated that true EPD can be determined objectively only at adequate erection. Therefore, the diagnosis should be based not on subjective opinion of the patient but on the results of artificial pharmacological erection or viagra-test in combination with visual erotic and genital stimulation. Vacuum erection test is not justified. In patients with congenital EPD rigidity depends much on correlation between perfusion volume and functional volume of the penis (cavernous volume). The problem of congenital EPD can be formulated as the problem of "long penis". Measurements of the penis in the group of 54 patients with congenital EPD registered a low penile coefficient in 67% cases while a mean length of the penis in all the examinees was longer than a mean standard one and was about 13 cm in relaxed condition. EPD patients often suffer from asthenodepressive disorders deteriorating the copulative function. Psychotherapy and medication of the depressive syndrome result in stabilization of the psychological condition improving quality of life 1.3 times. Thus, an integrative diagnostic and therapeutic approach, due selection of the patients for operative correction of penile deviation can improve quality of the treatment aimed both at correction of erectile malformation and psychosexual adaptation of the patients. PMID:16281840

  8. Deviations from the local field approximation in negative streamer heads

    NASA Astrophysics Data System (ADS)

    Li, Chao; Brok, W. J. M.; Ebert, Ute; van der Mullen, J. J. A. M.

    2007-06-01

    Negative streamer ionization fronts in nitrogen under normal conditions are investigated both in a particle model and in a fluid model in local field approximation. The parameter functions for the fluid model are derived from swarm experiments in the particle model. The front structure on the inner scale is investigated in a one-dimensional setting, allowing reasonable run time and memory consumption and high numerical accuracy without introducing superparticles. If the reduced electric field immediately before the front is ⩽50kV/(cmbar), solutions of fluid and particle model agree very well. If the field increases up to 200kV/(cmbar), the solutions of particle and fluid model deviate, in particular, the ionization level behind the front becomes up to 60% higher in the particle model while the velocity is rather insensitive. Particle and fluid model deviate because electrons with high energies do not yet fully run away from the front, but are somewhat ahead. This leads to increasing ionization rates in the particle model at the very tip of the front. The energy overshoot of electrons in the leading edge of the front actually agrees quantitatively with the energy overshoot in the leading edge of an electron swarm or avalanche in the same electric field.

  9. Maximum acceptable forces for repetitive ulnar deviation of the wrist.

    PubMed

    Snook, S H; Vaillancourt, D R; Ciriello, V M; Webster, B S

    1997-07-01

    The purpose of this experiment was to quantify maximum acceptable forces for ulnar deviation motions of the wrist at various repetition rates. Subjects grasped a handle with a power grip and moved it through a 1.40 rad (80 degrees) ulnar deviation wrist motion (similar to a knife cutting task). A psychophysical methodology was used in which the subject adjusted the resistance on the handle and the experiment manipulated or controlled all other variables. Two series of experiments were conducted. Thirteen subjects completed the first series, which investigated repetition rates of 15 and 20 motions per minute. Eleven subjects completed the second series, which investigated 15, 20, and 25 motions per minute. Subjects performed for 7 hours per day, 5 days per week, for 4 weeks in the first series and 5 weeks in the second series. The subjects were instructed to work as if they were on an incentive basis, getting paid for the amount of work they performed. Symptoms were recorded by the subjects during the last 5 minutes of each hour. The results are presented and compared with maximum acceptable forces for wrist flexion and extension. PMID:9208467

  10. The Time Deviation in Packet-Based Synchronization.

    PubMed

    Weiss, M A; Shenoi, Kishan

    2016-04-01

    The telecommunications industry has used the time deviation (TDEV) very effectively for specifying network equipment clock performance as well as the performance of timing signals generated by Central Office equipment such as primary reference clocks and building integrated timing supplies (BITS) and synchronization supply units (SSUs). We discuss here the development of TDEV, and the variations of TDEV motivated by the advent of packet-switching and the steady transformation of the telecom network from circuit-switched-based to packet-switched-based. We illustrate these with simulation of the performance of the precise time protocol (PTP) across a packet-switched network. We then apply published methods to automatically determine noise types, and use these to predict time dispersion from a master clock for a slave clock using these PTP packets to stay synchronized. The result shows how TDEV and the other deviations provide an extensive array of tools for telecom networks, as well as for general time and frequency applications. PMID:26529756

  11. Deviations from Curie-Weiss behavior in spin-glasses

    NASA Astrophysics Data System (ADS)

    Rao, K. V.; Fähnle, M.; Figueroa, E.; Beckman, O.; Hedman, L.

    1983-03-01

    The magnetic susceptibility in the spin-glass concentration regime of amorphous alloys (FexNi1-x)75P16B6Al3 with x=0.04, 0.06, and 0.08 has been measured using a superconducting quantum interference detector magnetometer with an external field of 5 Oe for temperatures 5<=T<=60.5 K, and a Faraday balance with an external field of 5 kOe for 4.3<=T<=300 K. We observe a high-temperature (T>20Tf) Curie-Weiss law with positive values for the paramagnetic Curie temperature, indicating predominantly ferromagnetic exchange couplings. At temperatures approaching the spin-glass freezing temperature, however, there are strong deviations from Curie-Weiss behavior. A simple theory is developed which allows a determination of the angular spin correlations in the spin-glass ground state from these deviations. The number of such correlated spins (1.5 to 4.4) determined from our data compares well with computer-simulation studies by Walker and Walstedt as well as data obtained by other authors for Au-Fe, Cu-Mn, and Co- and Mn-aluminosilicate spin-glasses.

  12. Chemical Principls Exemplified

    ERIC Educational Resources Information Center

    Plumb, Robert C.

    1973-01-01

    Two topics are discussed: (1) Stomach Upset Caused by Aspirin, illustrating principles of acid-base equilibrium and solubility; (2) Physical Chemistry of the Drinking Duck, illustrating principles of phase equilibria and thermodynamics. (DF)

  13. Principles of project management

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The basic principles of project management as practiced by NASA management personnel are presented. These principles are given as ground rules and guidelines to be used in the performance of research, development, construction or operational assignments.

  14. Principles of Modern Soccer.

    ERIC Educational Resources Information Center

    Beim, George

    This book is written to give a better understanding of the principles of modern soccer to coaches and players. In nine chapters the following elements of the game are covered: (1) the development of systems; (2) the principles of attack; (3) the principles of defense; (4) training games; (5) strategies employed in restarts; (6) physical fitness…

  15. Chemical Principles Exemplified

    ERIC Educational Resources Information Center

    Plumb, Robert C.

    1970-01-01

    This is the first of a new series of brief ancedotes about materials and phenomena which exemplify chemical principles. Examples include (1) the sea-lab experiment illustrating principles of the kinetic theory of gases, (2) snow-making machines illustrating principles of thermodynamics in gas expansions and phase changes, and (3) sunglasses that…

  16. 48 CFR 1.405 - Deviations pertaining to treaties and executive agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations from the FAR 1.405 Deviations... United States is a party. (b) Any deviation from the FAR required to comply with a treaty to which the United States is a party is authorized, unless the deviation would be inconsistent with FAR...

  17. Temperature deviation index and elderly mortality in Japan

    NASA Astrophysics Data System (ADS)

    Lim, Youn-Hee; Reid, Colleen E.; Honda, Yasushi; Kim, Ho

    2015-10-01

    Few studies have examined how the precedence of abnormal temperatures in previous neighboring years affects the population's health. In the present study, we attempted to quantify the health effects of abnormal weather patterns by creating a metric called the temperature deviation index (TDI) and estimated the effects of TDI on mortality in Japan. We used data from 47 prefectures in Japan to compute the TDI on days between May and September from 1966 to 2010. The TDI is a summed product of an indicator of absence of high temperatures in the neighboring years, and more weights were assigned to the years closest to the current year. To estimate the TDI effects on elderly mortality, we used generalized linear modeling with a Poisson distribution after adjusting for apparent temperature, barometric pressure, day of the week, and time trend. For each prefecture, we estimated the TDI effects and pooled the estimates to yield a national average for 1991-2010 in Japan. The estimated effects of TDI in middle- or high-latitude prefectures were greater than in low-latitude prefectures. The estimated national average of TDI effects was a 0.5 % (95 % confidence intervals [CI], 0.1, 1.0) increase in elderly mortality per 1-unit (around 1 standard deviation) increase in the TDI. The significant pooled estimation of TDI effects was mainly due to the TDI effects on summer days with moderate temperature (25th-49th percentile, mean temperature 22.9 °C): a 1.9 % (95 % CI, 1.1, 2.6) increase in elderly mortality per 1-unit increase in the TDI. However, TDI effects were insignificant in other temperature ranges. These findings suggest that elderly deaths increased on moderate temperature days in the summer that differed substantially from days during that time window in the neighboring years. Therefore, not only high temperature itself but also temperature deviation compared to previous years could be considered to be a risk factor for elderly mortality in the summer.

  18. Temperature deviation index and elderly mortality in Japan

    NASA Astrophysics Data System (ADS)

    Lim, Youn-Hee; Reid, Colleen E.; Honda, Yasushi; Kim, Ho

    2016-07-01

    Few studies have examined how the precedence of abnormal temperatures in previous neighboring years affects the population's health. In the present study, we attempted to quantify the health effects of abnormal weather patterns by creating a metric called the temperature deviation index (TDI) and estimated the effects of TDI on mortality in Japan. We used data from 47 prefectures in Japan to compute the TDI on days between May and September from 1966 to 2010. The TDI is a summed product of an indicator of absence of high temperatures in the neighboring years, and more weights were assigned to the years closest to the current year. To estimate the TDI effects on elderly mortality, we used generalized linear modeling with a Poisson distribution after adjusting for apparent temperature, barometric pressure, day of the week, and time trend. For each prefecture, we estimated the TDI effects and pooled the estimates to yield a national average for 1991-2010 in Japan. The estimated effects of TDI in middle- or high-latitude prefectures were greater than in low-latitude prefectures. The estimated national average of TDI effects was a 0.5 % (95 % confidence intervals [CI], 0.1, 1.0) increase in elderly mortality per 1-unit (around 1 standard deviation) increase in the TDI. The significant pooled estimation of TDI effects was mainly due to the TDI effects on summer days with moderate temperature (25th-49th percentile, mean temperature 22.9 °C): a 1.9 % (95 % CI, 1.1, 2.6) increase in elderly mortality per 1-unit increase in the TDI. However, TDI effects were insignificant in other temperature ranges. These findings suggest that elderly deaths increased on moderate temperature days in the summer that differed substantially from days during that time window in the neighboring years. Therefore, not only high temperature itself but also temperature deviation compared to previous years could be considered to be a risk factor for elderly mortality in the summer.

  19. Temperature deviation index and elderly mortality in Japan.

    PubMed

    Lim, Youn-Hee; Reid, Colleen E; Honda, Yasushi; Kim, Ho

    2016-07-01

    Few studies have examined how the precedence of abnormal temperatures in previous neighboring years affects the population's health. In the present study, we attempted to quantify the health effects of abnormal weather patterns by creating a metric called the temperature deviation index (TDI) and estimated the effects of TDI on mortality in Japan. We used data from 47 prefectures in Japan to compute the TDI on days between May and September from 1966 to 2010. The TDI is a summed product of an indicator of absence of high temperatures in the neighboring years, and more weights were assigned to the years closest to the current year. To estimate the TDI effects on elderly mortality, we used generalized linear modeling with a Poisson distribution after adjusting for apparent temperature, barometric pressure, day of the week, and time trend. For each prefecture, we estimated the TDI effects and pooled the estimates to yield a national average for 1991-2010 in Japan. The estimated effects of TDI in middle- or high-latitude prefectures were greater than in low-latitude prefectures. The estimated national average of TDI effects was a 0.5 % (95 % confidence intervals [CI], 0.1, 1.0) increase in elderly mortality per 1-unit (around 1 standard deviation) increase in the TDI. The significant pooled estimation of TDI effects was mainly due to the TDI effects on summer days with moderate temperature (25th-49th percentile, mean temperature 22.9 °C): a 1.9 % (95 % CI, 1.1, 2.6) increase in elderly mortality per 1-unit increase in the TDI. However, TDI effects were insignificant in other temperature ranges. These findings suggest that elderly deaths increased on moderate temperature days in the summer that differed substantially from days during that time window in the neighboring years. Therefore, not only high temperature itself but also temperature deviation compared to previous years could be considered to be a risk factor for elderly mortality in the summer. PMID

  20. Deviation from Universality in Collisions of Ultracold Li26 Molecules

    NASA Astrophysics Data System (ADS)

    Wang, Tout T.; Heo, Myoung-Sun; Rvachov, Timur M.; Cotta, Dylan A.; Ketterle, Wolfgang

    2013-04-01

    Collisions of Li26 molecules with free Li6 atoms reveal a striking deviation from universal predictions based on long-range van der Waals interactions. Li2 closed-channel molecules are formed in the highest vibrational state near a narrow Feshbach resonance and decay via two-body collisions with Li2, Li, and Na. For Li2+Li2 and Li2+Na, the decay rates agree with the universal predictions of the quantum Langevin model. In contrast, the rate for Li2+Li is exceptionally small, with an upper bound 10 times smaller than the universal prediction. This can be explained by the low density of available decay states in systems of light atoms [G. Quéméner, J.-M. Launay, and P. Honvault, Phys. Rev. A 75, 050701 (2007)PLRAAN1050-2947], for which such collisions have not been studied before.

  1. The deviation of growth model for transparent conductive graphene

    PubMed Central

    2014-01-01

    An approximate growth model was employed to predict the time required to grow a graphene film by chemical vapor deposition (CVD). Monolayer graphene films were synthesized on Cu foil at various hydrogen flow rates from 10 to 50 sccm. The sheet resistance of the graphene film was 310Ω/□ and the optical transmittance was 97.7%. The Raman intensity ratio of the G-peak to the 2D peak of the graphene film was as high as ~4 when the hydrogen flow rate was 30 sccm. The fitting curve obtained by the deviation equation of growth model closely matches the data. We believe that under the same conditions and with the same setup, the presented growth model can help manufacturers and academics to predict graphene growth time more accurately. PMID:25364316

  2. Deviations from uniform power law scaling in nonstationary time series

    NASA Technical Reports Server (NTRS)

    Viswanathan, G. M.; Peng, C. K.; Stanley, H. E.; Goldberger, A. L.

    1997-01-01

    A classic problem in physics is the analysis of highly nonstationary time series that typically exhibit long-range correlations. Here we test the hypothesis that the scaling properties of the dynamics of healthy physiological systems are more stable than those of pathological systems by studying beat-to-beat fluctuations in the human heart rate. We develop techniques based on the Fano factor and Allan factor functions, as well as on detrended fluctuation analysis, for quantifying deviations from uniform power-law scaling in nonstationary time series. By analyzing extremely long data sets of up to N = 10(5) beats for 11 healthy subjects, we find that the fluctuations in the heart rate scale approximately uniformly over several temporal orders of magnitude. By contrast, we find that in data sets of comparable length for 14 subjects with heart disease, the fluctuations grow erratically, indicating a loss of scaling stability.

  3. Deviations from ideal behavior in isotopic mixtures of ammonia

    NASA Astrophysics Data System (ADS)

    Lopes, J. N. Canongia; Rebelo, L. P. N.; Calado, J. C. G.

    2001-09-01

    The vapor pressure isotope effect between samples of isotopically substituted ammonia, NH3, ND3 and 15NH3, and their mixtures was measured as a function of temperature (225deviations from ideality in such "almost ideal" systems.

  4. Image contrast enhancement based on a local standard deviation model

    SciTech Connect

    Chang, Dah-Chung; Wu, Wen-Rong

    1996-12-31

    The adaptive contrast enhancement (ACE) algorithm is a widely used image enhancement method, which needs a contrast gain to adjust high frequency components of an image. In the literature, the gain is usually inversely proportional to the local standard deviation (LSD) or is a constant. But these cause two problems in practical applications, i.e., noise overenhancement and ringing artifact. In this paper a new gain is developed based on Hunt`s Gaussian image model to prevent the two defects. The new gain is a nonlinear function of LSD and has the desired characteristic emphasizing the LSD regions in which details are concentrated. We have applied the new ACE algorithm to chest x-ray images and the simulations show the effectiveness of the proposed algorithm.

  5. Spine deviations and orthodontic treatment of asymmetric malocclusions in children

    PubMed Central

    2012-01-01

    Background The aim of this randomized clinical trial was to assess the effect of early orthodontic treatment for unilateral posterior cross bite in the late deciduous and early mixed dentition using orthopedic parameters. Methods Early orthodontic treatment was performed by initial maxillary expansion and subsequent activator therapy (Münster treatment concept). The patient sample was initially comprised of 80 patients with unilateral posterior cross bite (mean age 7.3 years, SD 2.1 years). After randomization, 77 children attended the initial examination appointment (therapy = 37, control = 40); 31 children in the therapy group and 35 children in the control group were monitored at the follow-up examination (T2). The mean interval between T1 and T2 was 1.1 years (SD 0.2 years). Rasterstereography was used for back shape analysis at T1 and T2. Using the profile, the kyphotic and lordotic angle, the surface rotation, the lateral deviation, pelvic tilt and pelvic torsion, statistical differences at T1 and T2 between the therapy and control groups were calculated (t-test). Our working hypothesis was, that early orthodontic treatment can induce negative therapeutic changes in body posture through thoracic and lumbar position changes in preadolescents with uniltaral cross bite. Results No clinically relevant differences between the control and the therapy groups at T1 and T2 were found for the parameters of kyphotic and lordotic angle, the surface rotation, lateral deviation, pelvic tilt, and pelvic torsion. Conclusions Our working hypothesis was tested to be not correct (within the limitations of this study). This randomized clinical trial demonstrates that in a juvenile population with unilateral posterior cross bite the selected early orthodontic treatment protocol does not affect negatively the postural parameters. Trial registration DRKS00003497 on DRKS PMID:22906114

  6. Deviations of the energy-momentum tensor from equilibrium in the initial state for hydrodynamics from transport approaches

    NASA Astrophysics Data System (ADS)

    Oliinychenko, D.; Petersen, H.

    2016-03-01

    Many hybrid models of heavy ion collisions construct the initial state for hydrodynamics from transport models. Hydrodynamics requires that the energy-momentum tensor Tμ ν and four-currents jμ do not deviate considerably from the equilibrium ideal-fluid form, but the ones constructed from transport do not necessarily possess this property. In this work we investigate the space-time picture of Tμ ν deviations from equilibrium in Au+Au collisions using a coarse-grained transport approach. The collision energy is varied in the range Elab=5 -160 A GeV . The sensitivity of Tμ ν deviations from equilibrium to collision centrality, and other parameters such as the switching criterion, the amount of statistics used to construct the initial state, and the smearing parameter σ are investigated. For low statistics, deviations of Tμ ν from equilibrium are large and dominated by the effect of finite sampling. For large statistics, the pressure anisotropy plays the most significant role, while the off-diagonal components of Tμ ν are small in a large volume during the whole evolution. For all considered energies and centralities the pressure anisotropy exhibits a similar feature: there is a narrow interval of time when it rapidly drops in a considerable volume. This allows us to introduce an "isotropization time," which is found to decrease with energy and slightly increase with centrality. The isotropization times are larger than times typically used for initializing hydrodynamics.

  7. Driving Toward Guiding Principles

    PubMed Central

    Buckovich, Suzy A.; Rippen, Helga E.; Rozen, Michael J.

    1999-01-01

    As health care moves from paper to electronic data collection, providing easier access and dissemination of health information, the development of guiding privacy, confidentiality, and security principles is necessary to help balance the protection of patients' privacy interests against appropriate information access. A comparative review and analysis was done, based on a compilation of privacy, confidentiality, and security principles from many sources. Principles derived from ten identified sources were compared with each of the compiled principles to assess support level, uniformity, and inconsistencies. Of 28 compiled principles, 23 were supported by at least 50 percent of the sources. Technology could address at least 12 of the principles. Notable consistencies among the principles could provide a basis for consensus for further legislative and organizational work. It is imperative that all participants in our health care system work actively toward a viable resolution of this information privacy debate. PMID:10094065

  8. Deviation from Power Law Behavior in Landslide Phenomenon

    NASA Astrophysics Data System (ADS)

    Li, L.; Lan, H.; Wu, Y.

    2013-12-01

    Power law distribution of magnitude is widely observed in many natural hazards (e.g., earthquake, floods, tornadoes, and forest fires). Landslide is unique as the size distribution of landslide is characterized by a power law decrease with a rollover in the small size end. Yet, the emergence of the rollover, i.e., the deviation from power law behavior for small size landslides, remains a mystery. In this contribution, we grouped the forces applied on landslide bodies into two categories: 1) the forces proportional to the volume of failure mass (gravity and friction), and 2) the forces proportional to the area of failure surface (cohesion). Failure occurs when the forces proportional to volume exceed the forces proportional to surface area. As such, given a certain mechanical configuration, the failure volume to failure surface area ratio must exceed a corresponding threshold to guarantee a failure. Assuming all landslides share a uniform shape, which means the volume to surface area ratio of landslide regularly increase with the landslide volume, a cutoff of landslide volume distribution in the small size end can be defined. However, in realistic landslide phenomena, where heterogeneities of landslide shape and mechanical configuration are existent, a simple cutoff of landslide volume distribution does not exist. The stochasticity of landslide shape introduce a probability distribution of the volume to surface area ratio with regard to landslide volume, with which the probability that the volume to surface ratio exceed the threshold can be estimated regarding values of landslide volume. An experiment based on empirical data showed that this probability can induce the power law distribution of landslide volume roll down in the small size end. We therefore proposed that the constraints on the failure volume to failure surface area ratio together with the heterogeneity of landslide geometry and mechanical configuration attribute for the deviation from power law

  9. Criteria for deviation from predictions by the concentration addition model.

    PubMed

    Takeshita, Jun-Ichi; Seki, Masanori; Kamo, Masashi

    2016-07-01

    Loewe's additivity (concentration addition) is a well-known model for predicting the toxic effects of chemical mixtures under the additivity assumption of toxicity. However, from the perspective of chemical risk assessment and/or management, it is important to identify chemicals whose toxicities are additive when present concurrently, that is, it should be established whether there are chemical mixtures to which the concentration addition predictive model can be applied. The objective of the present study was to develop criteria for judging test results that deviated from the predictions by the concentration addition chemical mixture model. These criteria were based on the confidence interval of the concentration addition model's prediction and on estimation of errors of the predicted concentration-effect curves by toxicity tests after exposure to single chemicals. A log-logit model with 2 parameters was assumed for the concentration-effect curve of each individual chemical. These parameters were determined by the maximum-likelihood method, and the criteria were defined using the variances and the covariance of the parameters. In addition, the criteria were applied to a toxicity test of a binary mixture of p-n-nonylphenol and p-n-octylphenol using the Japanese killifish, medaka (Oryzias latipes). Consequently, the concentration addition model using confidence interval was capable of predicting the test results at any level, and no reason for rejecting the concentration addition was found. Environ Toxicol Chem 2016;35:1806-1814. © 2015 SETAC. PMID:26660330

  10. Gait Deviations in Children with Autism Spectrum Disorders: A Review

    PubMed Central

    Kindregan, Deirdre; Gallagher, Louise; Gormley, John

    2015-01-01

    In recent years, it has become clear that children with autism spectrum disorders (ASDs) have difficulty with gross motor function and coordination, factors which influence gait. Knowledge of gait abnormalities may be useful for assessment and treatment planning. This paper reviews the literature assessing gait deviations in children with ASD. Five online databases were searched using keywords “gait” and “autism,” and 11 studies were found which examined gait in childhood ASD. Children with ASD tend to augment their walking stability with a reduced stride length, increased step width and therefore wider base of support, and increased time in the stance phase. Children with ASD have reduced range of motion at the ankle and knee during gait, with increased hip flexion. Decreased peak hip flexor and ankle plantar flexor moments in children with ASD may imply weakness around these joints, which is further exhibited by a reduction in ground reaction forces at toe-off in children with ASD. Children with ASD have altered gait patterns to healthy controls, widened base of support, and reduced range of motion. Several studies refer to cerebellar and basal ganglia involvement as the patterns described suggest alterations in those areas of the brain. Further research should compare children with ASD to other clinical groups to improve assessment and treatment planning. PMID:25922766

  11. Deviation from corresponding-states behaviour for polar fluids

    NASA Astrophysics Data System (ADS)

    van Leeuwen, M. E.

    The influence of the strength of the reduced dipole moment μ* of a Stockmayer fluid on thermodynamic phase behaviour is systematically investigated by means of computer simulations. Gibbs ensemble simulation data are presented for Stockmayer fluids with μ*2=5 and μ*2=6 in the reduced temperature range of 0·78-0·98 (respectively 0·99). Critical properties are estimated from Gibbs ensemble Monte Carlo data. The critical temperature increases strongly with increasing dipole moment, and the critical density shows a decrease for higher dipole moment values. The critical pressure increases only slightly, with the resulting reduced compressibility factor showing a clear decreasing trend. These trends are correlated with the reduced dipole moment. The Padé approximation of perturbation theory, compared with four other theories, follows the 'exact' critical-property correlations closest. The simulation results show that dipolar forces alone are sufficient to induce a deviation from corresponding-states behaviour: with increasing reduced dipole moment, the saturated-liquid densities and enthalpies of vaporization increase.

  12. Weighted Wilcoxon-type Smoothly Clipped Absolute Deviation Method

    PubMed Central

    Wang, Lan; Li, Runze

    2009-01-01

    Summary Shrinkage-type variable selection procedures have recently seen increasing applications in biomedical research. However, their performance can be adversely influenced by outliers in either the response or the covariate space. This paper proposes a weighted Wilcoxon-type smoothly clipped absolute deviation (WW-SCAD) method, which deals with robust variable selection and robust estimation simultaneously. The new procedure can be conveniently implemented with the statistical software R. We establish that the WW-SCAD correctly identifies the set of zero coefficients with probability approaching one and estimates the nonzero coefficients with the rate n−1/2. Moreover, with appropriately chosen weights the WW-SCAD is robust with respect to outliers in both the x and y directions. The important special case with constant weights yields an oracle-type estimator with high efficiency at the presence of heavier-tailed random errors. The robustness of the WW-SCAD is partly justified by its asymptotic performance under local shrinking contamination. We propose a BIC-type tuning parameter selector for the WW-SCAD. The performance of the WW-SCAD is demonstrated via simulations and by an application to a study that investigates the effects of personal characteristics and dietary factors on plasma beta-carotene level. PMID:18647294

  13. Teaching Standard Deviation by Building from Student Invention

    NASA Astrophysics Data System (ADS)

    Day, James; Nakahara, Hiroko; Bonn, Doug

    2010-11-01

    First-year physics laboratories are often driven by a mix of goals that includes the illustration or discovery of basic physics principles and a myriad of technical skills involving specific equipment, data analysis, and report writing. The sheer number of such goals seems guaranteed to produce cognitive overload, even when highly detailed "cookbook" instructions are given. Recent studies indicate that this approach leaves students with a poor conceptual understanding of one of the most important features of laboratory physics and of the real world of science, in general: the development of an understanding of the nature of measurement and its attendant uncertainty . While students might be able to reproduce certain technical manipulations of data, as novice thinkers they lack the mental scaffolding that allows an expert to organize and apply this knowledge.2,3 Our goal is to put novices on the path to expertise, so that they will be able to transfer their knowledge to novel situations.

  14. Spectral Relative Standard Deviation: A Practical Benchmark in Metabolomics

    EPA Science Inventory

    Metabolomics datasets, by definition, comprise of measurements of large numbers of metabolites. Both technical (analytical) and biological factors will induce variation within these measurements that is not consistent across all metabolites. Consequently, criteria are required to...

  15. New identification method for Hammerstein models based on approximate least absolute deviation

    NASA Astrophysics Data System (ADS)

    Xu, Bao-Chang; Zhang, Ying-Dan

    2016-07-01

    Disorder and peak noises or large disturbances can deteriorate the identification effects of Hammerstein non-linear models when using the least-square (LS) method. The least absolute deviation technique can be used to resolve this problem; however, its absolute value cannot meet the need of differentiability required by most algorithms. To improve robustness and resolve the non-differentiable problem, an approximate least absolute deviation (ALAD) objective function is established by introducing a deterministic function that exhibits the characteristics of absolute value under certain situations. A new identification method for Hammerstein models based on ALAD is thus developed in this paper. The basic idea of this method is to apply the stochastic approximation theory in the process of deriving the recursive equations. After identifying the parameter matrix of the Hammerstein model via the new algorithm, the product terms in the matrix are separated by calculating the average values. Finally, algorithm convergence is proven by applying the ordinary differential equation method. The proposed algorithm has a better robustness as compared to other LS methods, particularly when abnormal points exist in the measured data. Furthermore, the proposed algorithm is easier to apply and converges faster. The simulation results demonstrate the efficacy of the proposed algorithm.

  16. A model for the transport of cuttings in highly deviated wells

    SciTech Connect

    Gavignet, A.A.; Sobey, I.J.

    1986-01-01

    At present, drilling of highly deviated wells is complicated by the possibility of the formation of a thick bed of cuttings at low flow rates. The bed of cuttings can cause large torque loads on drill pipe and can fall back around the bit resulting in a stuck bit. Previous investigators have made experimental observations which show that bed formation is characterized by a relatively rapid increase in bed thickness as either the flow rate is lowered past some critical value, or as the deviation from the vertical increases. The authors present a simple model which explains these observations. The model shows that the bed thickness is controlled by the interfacial stress caused by the different velocities of the mud and the cuttings layer. The results confirm previous observations that bed formation is relatively insensitive to mud rheology. Eccentricity of the drill pipe in the hole is an important factor. The model is used to determine critical flow rate needed to prevent the formation of a thick bed of cuttings and the inclination, hole size and rate of penetration are varied.

  17. On the superposition principle in interference experiments

    PubMed Central

    Sinha, Aninda; H. Vijay, Aravind; Sinha, Urbasi

    2015-01-01

    The superposition principle is usually incorrectly applied in interference experiments. This has recently been investigated through numerics based on Finite Difference Time Domain (FDTD) methods as well as the Feynman path integral formalism. In the current work, we have derived an analytic formula for the Sorkin parameter which can be used to determine the deviation from the application of the principle. We have found excellent agreement between the analytic distribution and those that have been earlier estimated by numerical integration as well as resource intensive FDTD simulations. The analytic handle would be useful for comparing theory with future experiments. It is applicable both to physics based on classical wave equations as well as the non-relativistic Schrödinger equation. PMID:25973948

  18. Guiding Principles for Evaluators.

    ERIC Educational Resources Information Center

    Shadish, William R., Ed.; And Others

    1995-01-01

    The 12 articles (including an index) of this theme issue are devoted to documenting and critiquing the American Evaluation Association's "Guiding Principles for Evaluators," a code of ethics and standards. The development of these principles is traced, and their strengths and weaknesses are analyzed at general and specific levels. (SLD)

  19. Assessment Principles and Tools

    PubMed Central

    Golnik, Karl C.

    2014-01-01

    The goal of ophthalmology residency training is to produce competent ophthalmologists. Competence can only be determined by appropriately assessing resident performance. There are accepted guiding principles that should be applied to competence assessment methods. These principles are enumerated herein and ophthalmology-specific assessment tools that are available are described. PMID:24791100

  20. Principled Grammar Teaching

    ERIC Educational Resources Information Center

    Batstone, Rob; Ellis, Rod

    2009-01-01

    A key aspect of the acquisition of grammar for second language learners involves learning how to make appropriate connections between grammatical forms and the meanings which they typically signal. We argue that learning form/function mappings involves three interrelated principles. The first is the Given-to-New Principle, where existing world…

  1. Hamilton's Principle for Beginners

    ERIC Educational Resources Information Center

    Brun, J. L.

    2007-01-01

    I find that students have difficulty with Hamilton's principle, at least the first time they come into contact with it, and therefore it is worth designing some examples to help students grasp its complex meaning. This paper supplies the simplest example to consolidate the learning of the quoted principle: that of a free particle moving along a…

  2. The genetic difference principle.

    PubMed

    Farrelly, Colin

    2004-01-01

    In the newly emerging debates about genetics and justice three distinct principles have begun to emerge concerning what the distributive aim of genetic interventions should be. These principles are: genetic equality, a genetic decent minimum, and the genetic difference principle. In this paper, I examine the rationale of each of these principles and argue that genetic equality and a genetic decent minimum are ill-equipped to tackle what I call the currency problem and the problem of weight. The genetic difference principle is the most promising of the three principles and I develop this principle so that it takes seriously the concerns of just health care and distributive justice in general. Given the strains on public funds for other important social programmes, the costs of pursuing genetic interventions and the nature of genetic interventions, I conclude that a more lax interpretation of the genetic difference principle is appropriate. This interpretation stipulates that genetic inequalities should be arranged so that they are to the greatest reasonable benefit of the least advantaged. Such a proposal is consistent with prioritarianism and provides some practical guidance for non-ideal societies--that is, societies that do not have the endless amount of resources needed to satisfy every requirement of justice. PMID:15186680

  3. The Principles of Leadership.

    ERIC Educational Resources Information Center

    Burns, Gerald P.

    The primary but not exclusive concern in this monograph is the principles and qualities of dynamic leaders of people rather than of ideas or cultural and artistic pursuits. Theories of leadership in the past, present, and future are discussed, as are the principles, rewards, exercise, and philosophy of leadership. A bibliography is included. (MSE)

  4. Government Information Policy Principles.

    ERIC Educational Resources Information Center

    Hernon, Peter

    1991-01-01

    Analyzes the utility of policy principles advanced by professional associations for public access to government information. The National Commission on Libraries and Information Science (NCLIS), the Information Industry Association (IIA), and the Office of Technology Assessment (OTA) urge the adoption of principles for the dissemination of public…

  5. Surgical management of unilateral elevator deficiency associated with horizontal deviation using a modified Knapp's procedure.

    PubMed

    Kamlesh; Dadeya, Subhash

    2003-01-01

    Both horizontal recti are transpositioned in unilateral elevator deficiency, leaving no alternative to correct any significant ipsilateral horizontal deviation. An effective method to correct vertical and horizontal deviations simultaneously is reported. A modified Knapp's procedure was performed by transposition of the superior half of equally divided (up to 15 mm) medial and lateral recti for vertical deviation and the inferior half after suitable recession or resection for horizontal deviation. This procedure was performed in ten patients who had type II unilateral elevator deficiency with horizontal deviation ranging from 18 to 45 prism diopters (PD). We were able to correct 20 PD of horizontal deviation and 25 PD of vertical deviation with a modified Knapp's procedure without any significant adverse effects after a follow-up of 21 months. A modified Knapp's procedure is recommended for unilateral elevator deficiency associated with horizontal deviation. PMID:12757102

  6. 48 CFR 2901.405 - Deviations pertaining to treaties and executive agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DOLAR 2901.405 Deviations pertaining to treaties and executive agreements. (a) The Director, DAMS is... deviations not authorized by FAR 1.405(b) or (c), the Director, DAMS, will process the request for...

  7. Principlism and communitarianism.

    PubMed

    Callahan, D

    2003-10-01

    The decline in the interest in ethical theory is first outlined, as a background to the author's discussion of principlism. The author's own stance, that of a communitarian philosopher, is then described, before the subject of principlism itself is addressed. Two problems stand in the way of the author's embracing principlism: its individualistic bias and its capacity to block substantive ethical inquiry. The more serious problem the author finds to be its blocking function. Discussing the four scenarios the author finds that the utility of principlism is shown in the two scenarios about Jehovah's Witnesses but that when it comes to selling kidneys for transplantation and germline enhancement, principlism is of little help. PMID:14519838

  8. Simulation study on slant-to-vertical deviation in two dimensional TEC mapping over the ionosphere equatorial anomaly

    NASA Astrophysics Data System (ADS)

    Yu, Tao; Mao, Tian; Wang, Yungang; Zeng, Zhongcao; Xia, Chunliang; Wu, Fenglei; Wang, Le

    2014-08-01

    With the rapid increase of GPS/GNSS receivers being deployed and operated in China, real-time GPS data from nearly a thousand sites are available at the National Center for Space Weather, China Meteorology Administration. However, it is challenging to generate a high-quality regional total electron content (TEC) map with the traditional two-dimensional (2-D) retrieval scheme because a large horizontal gradient has been reported over east-south Asia due to the northern equatorial ionization anomaly. We developed an Ionosphere Data Assimilation Analysis System (IDAAS), which is described in this study, using an International Reference Ionosphere (IRI) model as the background and applying a Kalman filter for updated observations. The IDAAS can reconstruct a three-dimensional ionosphere with the GPS slant TEC. The inverse slant TEC correlates well with observations both for GPS sites involved in the reconstruction and sites that are not involved. Based on the IDAAS, simulations were performed to investigate the deviation relative to the slant-to-vertical conversion (STV). The results indicate that the relative deviation induced by slant-to-vertical conversion may be significant in certain instances, and the deviation varies from 0% to 40% when the elevation decreases from 90° to 15°, while the relative IDAAS deviation is much smaller and varies from -5% to 15% without an elevation dependence. Compared with ‘true TEC’ map derived from the model, there is large difference in STV TEC map but no obvious discrepancy in IDAAS map. Generally, the IDAAS TEC map is much closer to the “true TEC” than is STV TEC map is. It is suggested that three-dimensional inversion technique is necessary for GPS observations of low elevation at an equatorial anomaly region, wherein the high horizontal electron density gradient may produce significant slant-to-vertical deviations using the two-dimensional STV inversion method.

  9. Principles for system level electrochemistry

    NASA Technical Reports Server (NTRS)

    Thaller, L. H.

    1986-01-01

    The higher power and higher voltage levels anticipated for future space missions have required a careful review of the techniques currently in use to preclude battery problems that are related to the dispersion characteristics of the individual cells. Not only are the out-of-balance problems accentuated in these larger systems, but the thermal management considerations also require a greater degree of accurate design. Newer concepts which employ active cooling techniques are being developed which permit higher rates of discharge and tighter packing densities for the electrochemical components. This paper will put forward six semi-independent principles relating to battery systems. These principles will progressively address cell, battery and finally system related aspects of large electrochemical storage systems.

  10. 48 CFR 601.405 - Deviations pertaining to treaties and executive agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DEPARTMENT OF STATE GENERAL DEPARTMENT OF STATE ACQUISITION REGULATIONS SYSTEM Deviations from the FAR 601... determine whether a deviation pertaining to treaties and executive agreements is authorized under FAR 1.405 or that a request for deviation is required under FAR 1.405(e)....

  11. Revisiting a 90-Year-Old Debate: The Advantages of the Mean Deviation

    ERIC Educational Resources Information Center

    Gorard, Stephen

    2005-01-01

    This paper discusses the reliance of numerical analysis on the concept of the standard deviation, and its close relative the variance. It suggests that the original reasons why the standard deviation concept has permeated traditional statistics are no longer clearly valid, if they ever were. The absolute mean deviation, it is argued here, has many…

  12. Giant effective mass deviations near the magnetic field-induced minigap in double quantum wells

    SciTech Connect

    Harff, N.E. |; Simmons, J.A.; Lyo, S.K.; Klem, J.F.; Goodnick, S.M.

    1994-09-01

    The authors report major deviations in the electron effective mass m* near the partial energy gap, or minigap, formed in strongly coupled double quantum wells (QWs) by an anticrossing of the two QW dispersion curves. The anticrossing and minigap are induced by an in-plane magnetic field B{sub {parallel}} and give rise to large distortions in the Fermi surface and density of states, including a Van Hove singularity. Sweeping B{sub {parallel}} moves the minigap through the Fermi level, with the upper and lower gap edges producing a sharp maximum and minimum in the low-temperature in-plane conductance, in agreement with theoretical calculations. The temperature dependence of Shubnikov-de Haas (SdH) oscillations appearing in a tilted magnetic field yield a decreased m* {le} 1/3 m*{sub GaAs} near the upper gap edge, and indicate an increase in m* near the lower gap edge.

  13. Optical glass: deviation of relative partial dispersion from the normal line-need for a common definition

    NASA Astrophysics Data System (ADS)

    Hartmann, Peter

    2015-10-01

    The design of high-quality imaging lenses continues to strive for the best color trueness over wider and wider wavelength ranges such as for multiwavelength fluorescence microscopy or hyperspectral imaging. Glasses suitable for sharp images at more than two wavelengths must differ in their dispersion from the classical crown and flint glass types, which gather along a straight line in a plot of the relative partial dispersion against the Abbe number. Glasses suitable for multicolor correction can be recognized by a considerable deviation of their relative partial dispersion from this normal line. Originally, the normal lines for different relative partial dispersions were defined by using the SCHOTT glass types K7 and F2. Today's data sheets of all glass manufacturers contain numerical values for deviations of relative partial dispersions from the normal lines. A comparison of almost identical glasses shows differences between these deviations being too large, obviously coming from different versions of K7 and F2 dispersion curves used. For preselection in designs and for direct comparison of glass types, it is necessary to agree on common dispersion curves each for K7 and for F2 in order to obtain really comparable values for deviations of the relative partial dispersion from the normal line.

  14. What Metadata Principles Apply to Scientific Data?

    NASA Astrophysics Data System (ADS)

    Mayernik, M. S.

    2014-12-01

    Information researchers and professionals based in the library and information science fields often approach their work through developing and applying defined sets of principles. For example, for over 100 years, the evolution of library cataloging practice has largely been driven by debates (which are still ongoing) about the fundamental principles of cataloging and how those principles should manifest in rules for cataloging. Similarly, the development of archival research and practices over the past century has proceeded hand-in-hand with the emergence of principles of archival arrangement and description, such as maintaining the original order of records and documenting provenance. This project examines principles related to the creation of metadata for scientific data. The presentation will outline: 1) how understandings and implementations of metadata can range broadly depending on the institutional context, and 2) how metadata principles developed by the library and information science community might apply to metadata developments for scientific data. The development and formalization of such principles would contribute to the development of metadata practices and standards in a wide range of institutions, including data repositories, libraries, and research centers. Shared metadata principles would potentially be useful in streamlining data discovery and integration, and would also benefit the growing efforts to formalize data curation education.

  15. Deviation of permeable coarse-grained boundary resistance from Nikuradse's observations

    NASA Astrophysics Data System (ADS)

    Cheng, Nian-Sheng; Liu, Xingnian; Chen, Xingwei; Qiao, Changkai

    2016-02-01

    Nikuradse's (1933) rough pipe study is enormously influential in the understanding of flow resistance over a sediment bed. However, the rough boundary employed in Nikuradse's study differs from permeable sediment beds in rivers. This implies that the results derived from the rough pipe experiments may not be applicable for flows over a permeable coarse-grained bed. The present study aimed to explore to what extent the flow resistance of a permeable coarse-grained boundary deviates from the Nikuradse's observations. Experiments were conducted with rough pipes, which were prepared by overlaying the inner wall with one to four layers of spherical beads. The single layer roughness resembles the experimental setup reported in Nikuradse's study, while the multilayer of grains allows significant flow to pass through the porous roughness layer. In addition, the ratio of grain diameter, k, to pipe diameter, d, was chosen to be one to two orders greater than the range (0.001 < k/d < 0.033) adopted in Nikuradse's experiments. The data show that the friction factor deviates significantly from the prediction based on Nikuradse's rough pipe relation. For hydraulically rough pipes, the friction factor is found to be proportional to the squared ratio of the grain diameter to nominal pipe diameter. This result is different from the one-third power function as implied by Nikuradse's rough pipe relation or the Manning-Strickler formula but agrees well with laboratory observations of open channel resistance in the presence of large-scale roughness. The measurements also suggest the existence of a laminar flow regime, in which the friction factor is inversely proportional to the Reynolds number. The observed variations in the flow resistance are attributed to both wall permeability and large-scale roughness.

  16. Physical Principles of Evolution

    NASA Astrophysics Data System (ADS)

    Schuster, Peter

    Theoretical biology is incomplete without a comprehensive theory of evolution, since evolution is at the core of biological thought. Evolution is visualized as a migration process in genotype or sequence space that is either an adaptive walk driven by some fitness gradient or a random walk in the absence of (sufficiently large) fitness differences. The Darwinian concept of natural selection consisting in the interplay of variation and selection is based on a dichotomy: All variations occur on genotypes whereas selection operates on phenotypes, and relations between genotypes and phenotypes, as encapsulated in a mapping from genotype space into phenotype space, are central to an understanding of evolution. Fitness is conceived as a function of the phenotype, represented by a second mapping from phenotype space into nonnegative real numbers. In the biology of organisms, genotype-phenotype maps are enormously complex and relevant information on them is exceedingly scarce. The situation is better in the case of viruses but so far only one example of a genotype-phenotype map, the mapping of RNA sequences into RNA secondary structures, has been investigated in sufficient detail. It provides direct information on RNA selection in vitro and test-tube evolution, and it is a basis for testing in silico evolution on a realistic fitness landscape. Most of the modeling efforts in theoretical and mathematical biology today are done by means of differential equations but stochastic effects are of undeniably great importance for evolution. Population sizes are much smaller than the numbers of genotypes constituting sequence space. Every mutant, after all, has to begin with a single copy. Evolution can be modeled by a chemical master equation, which (in principle) can be approximated by a stochastic differential equation. In addition, simulation tools are available that compute trajectories for master equations. The accessible population sizes in the range of 10^7le Nle 10

  17. Deviation from the formulated target weight of ingredients loaded into high milk yield cow recipes on California dairies.

    PubMed

    Trillo, Y; Lago, A; Silva-Del-Río, N

    2016-07-01

    Nutrient composition of the feed and formulated ration often differ depending on uncertainties in DM content and nutrient composition of ingredients, as well as from feeder errors during loading. The objective of this study was to describe the deviation from target weight for the high-producing cow ration (HCR) and premix (HCP) on 26 California dairies ranging in size from 1,100 to 6,900 cows. Records from a consecutive 12-mo period were extracted from FeedWatch 7 (Valley Agricultural Software Inc., Tulare, CA), a feeding management software. Variables extracted and studied were date, recipe type, recipe number, ingredient, loading sequence, target weight, weight, and tolerance level (TL, deviation allowed per ingredient during loading). Based on the distribution of the deviation from target weight for the 8 most common ingredients, loading accuracy (quartile 1; small: |<10| kg; medium |10| to |20| kg; large |>20| kg), loading precision (interquartile range=quartile 3 to 1; small: <20kg; medium: 20 to 40kg; large >40kg), and extreme observations (quartile 3; small: |<25| kg; medium: |25| to |40| kg; large: |>40| kg) were described. Descriptive statistics were conducted with SAS 9.4 (SAS Institute Inc., Cary, NC). The median TL assigned to ingredients across dairies ranged from 0 to 90kg. At the ingredient level, the TL allowed a deviation from the median ingredient target weight of 0 to 2 (53.9%), >2 to 5 (25.5%), >5 to 10 (11.6%), or >10% (8.9%). A total of 2.5% of the loads did not reach the target weight set by the TL, ranging from 0.1 to 21.1% loads across dairies. Ingredient deviation from the formulated target weight across dairies was below target 49.1% of the time [<-10 (2.5%), -10 to <-5 (4.8%), -5 to <-2 (8.9%), -2 to <0% (32.8%)] or at or above target 50.9% of the time [0 (3.9%), >0 to 2 (36.7%), >2 to 5 (8.9%), >5 to 10 (1.2%), >10% (0.2%)]. Five dairies loaded ingredients with adequate accuracy (small to medium, quartile 1) and adequate precision

  18. Archimedes' Principle in Action

    ERIC Educational Resources Information Center

    Kires, Marian

    2007-01-01

    The conceptual understanding of Archimedes' principle can be verified in experimental procedures which determine mass and density using a floating object. This is demonstrated by simple experiments using graduated beakers. (Contains 5 figures.)

  19. Chemical Principles Exemplified

    ERIC Educational Resources Information Center

    Plumb, Robert C.

    1972-01-01

    Collection of two short descriptions of chemical principles seen in life situations: the autocatalytic reaction seen in the bombardier beetle, and molecular potential energy used for quick roasting of beef. Brief reference is also made to methanol lighters. (PS)

  20. Global ethics and principlism.

    PubMed

    Gordon, John-Stewart

    2011-09-01

    This article examines the special relation between common morality and particular moralities in the four-principles approach and its use for global ethics. It is argued that the special dialectical relation between common morality and particular moralities is the key to bridging the gap between ethical universalism and relativism. The four-principles approach is a good model for a global bioethics by virtue of its ability to mediate successfully between universal demands and cultural diversity. The principle of autonomy (i.e., the idea of individual informed consent), however, does need to be revised so as to make it compatible with alternatives such as family- or community-informed consent. The upshot is that the contribution of the four-principles approach to global ethics lies in the so-called dialectical process and its power to deal with cross-cultural issues against the background of universal demands by joining them together. PMID:22073817

  1. Principles of Tendon Transfer.

    PubMed

    Wilbur, Danielle; Hammert, Warren C

    2016-08-01

    Tendon transfers provide a substitute, either temporary or permanent, when function is lost due to neurologic injury in stroke, cerebral palsy or central nervous system lesions, peripheral nerve injuries, or injuries to the musculotendinous unit itself. This article reviews the basic principles of tendon transfer, which are important when planning surgery and essential for an optimal outcome. In addition, concepts for coapting the tendons during surgery and general principles to be followed during the rehabilitation process are discussed. PMID:27387072

  2. Hulls for Large Seaplanes

    NASA Technical Reports Server (NTRS)

    Magaldi, Giulio

    1925-01-01

    In reality, the principle of similitude is not applicable to the hulls, the designing of which increases in difficulty with increasing size of the seaplanes. In order to formulate, at least in a general way, the basic principles of calculation, we must first summarize the essential characteristics of a hull with reference to its gradual enlargement. In this study, we will disregard hulls with wing stubs, as being inapplicable to large seaplanes.

  3. Deviations from Boltzmann-Gibbs Statistics in Confined Optical Lattices.

    PubMed

    Dechant, Andreas; Kessler, David A; Barkai, Eli

    2015-10-23

    We investigate the semiclassical phase-space probability distribution P(x,p) of cold atoms in a Sisyphus cooling lattice with an additional harmonic confinement. We pose the question of whether this nonequilibrium steady state satisfies the equivalence of energy and probability. This equivalence is the foundation of Boltzmann-Gibbs and generalized thermostatic statistics, and a prerequisite for the description in terms of a temperature. At large energies, P(x,p) depends only on the Hamiltonian H(x,p) and the answer to the question is yes. In distinction to the Boltzmann-Gibbs state, the large-energy tails are power laws P(x,p)∝H(x,p)(-1/D), where D is related to the depth of the optical lattice. At intermediate energies, however, P(x,p) cannot be expressed as a function of the Hamiltonian and the equivalence between energy and probability breaks down. As a consequence the average potential and kinetic energy differ and no well-defined temperature can be assigned. The Boltzmann-Gibbs state is regained only in the limit of deep optical lattices. For strong confinement relative to the damping, we derive an explicit expression for the stationary phase-space distribution. PMID:26551114

  4. Significance of root-mean-square deviation in comparing three-dimensional structures of globular proteins.

    PubMed

    Maiorov, V N; Crippen, G M

    1994-01-14

    In the study of globular protein conformations, one customarily measures the similarity in three-dimensional structure by the root-mean-square deviation (RMSD) of the C alpha atomic coordinates after optimal rigid body superposition. Even when the two protein structures each consist of a single chain having the same number of residues so that the matching of C alpha atoms is obvious, it is not clear how to interpret the RMSD. A very large value means they are dissimilar, and zero means they are identical in conformation, but at what intermediate values are they particularly similar or clearly dissimilar? While many workers in the field have chosen arbitrary cutoffs, and others have judged values of RMSD according to the observed distribution of RMSD for random structures, we propose a self-referential, non-statistical standard. We take two conformers to be intrinsically similar if their RMSD is smaller than that when one of them is mirror inverted. Because the structures considered here are not arbitrary configurations of point atoms, but are compact, globular, polypeptide chains, our definition is closely related to similarity in radius of gyration and overall chain folding patterns. Being strongly similar in our sense implies that the radii of gyration must be nearly identical, the root-mean-square deviation in interatomic distances is linearly related to RMSD, and the two chains must have the same general fold. Only when the RMSD exceeds this level can parts of the polypeptide chain undergo nontrivial rearrangements while remaining globular. This enables us to judge when a prediction of a protein's conformation is "correct except for minor perturbations", or when the ensemble of protein structures deduced from NMR experiments are "basically in mutual agreement". PMID:8289285

  5. Oxidation photochemistry in the Southern Atlantic boundary layer: unexpected deviations of photochemical steady state

    NASA Astrophysics Data System (ADS)

    Hosaynali Beygi, Z.; Fischer, H.; Harder, H. D.; Martinez, M.; Sander, R.; Williams, J.; Brookes, D. M.; Monks, P. S.; Lelieveld, J.

    2011-03-01

    Ozone (O3) is a photochemical oxidant, an air pollutant and a greenhouse gas. As the main precursor of the hydroxyl radical (OH) it strongly affects the oxidation power of the atmosphere. The remote marine boundary layer (MBL) is considered an important region in terms of chemical O3 loss; however surface-based atmospheric observations are sparse and the photochemical processes are not well understood. To investigate the photochemistry under the clean background conditions of the Southern Atlantic Ocean, ship measurements of NO, NO2, O3, JNO2, J(O1D), HO2, OH, ROx and a range of meteorological parameters were carried out. The concentrations of NO and NO2 measured on board the French research vessel Marion-Dufresne (28° S-57° S, 46° W-34° E) in March 2007, are among the lowest yet observed. The data is evaluated for consistency with photochemical steady state (PSS) conditions, and the calculations indicate substantial deviations from PSS (Φ>1). The deviations observed under low NOx conditions (5-25 pptv) demonstrate a remarkable upward tendency in the Leighton ratio (used to characterize PSS) with increasing NOx mixing ratio and JNO2 intensity. It is a paradigm in atmospheric chemistry that OH largely controls the oxidation efficiency of the atmosphere. However, evidence is growing that for unpolluted low-NOx (NO + NO2) conditions the atmospheric oxidant budget is poorly understood. Nevertheless, for the very cleanest conditions, typical for the remote marine boundary layer, good model agreement with measured OH and HO2 radicals has been interpreted as accurate understanding of baseline photochemistry. Here we show that such agreement can be deceptive and that a yet unidentified oxidant is needed to explain the photochemical conditions observed at 40°-60° S over the Atlantic Ocean.

  6. Oxidation photochemistry in the Southern Atlantic boundary layer: unexpected deviations of photochemical steady state

    NASA Astrophysics Data System (ADS)

    Hosaynali Beygi, Z.; Fischer, H.; Harder, H. D.; Martinez, M.; Sander, R.; Williams, J.; Brookes, D. M.; Monks, P. S.; Lelieveld, J.

    2011-08-01

    Ozone (O3) is a photochemical oxidant, an air pollutant and a greenhouse gas. As the main precursor of the hydroxyl radical (OH) it strongly affects the oxidation power of the atmosphere. The remote marine boundary layer (MBL) is considered an important region in terms of chemical O3 loss; however surface-based atmospheric observations are sparse and the photochemical processes are not well understood. To investigate the photochemistry under the clean background conditions of the Southern Atlantic Ocean, ship measurements of NO, NO2, O3, JNO2, J(O1D), HO2, OH, ROx and a range of meteorological parameters were carried out. The concentrations of NO and NO2 measured on board the French research vessel Marion-Dufresne (28° S-57° S, 46° W-34° E) in March 2007, are among the lowest yet observed. The data is evaluated for consistency with photochemical steady state (PSS) conditions, and the calculations indicate substantial deviations from PSS (Φ>1). The deviations observed under low NOx conditions (5-25 pptv) demonstrate a remarkable upward tendency in the Leighton ratio (used to characterize PSS) with increasing NOx mixing ratio and JNO2 intensity. It is a paradigm in atmospheric chemistry that OH largely controls the oxidation efficiency of the atmosphere. However, evidence is growing that for unpolluted low-NOx (NO + NO2) conditions the atmospheric oxidant budget is poorly understood. Nevertheless, for the very cleanest conditions, typical for the remote marine boundary layer, good model agreement with measured OH and HO2 radicals has been interpreted as accurate understanding of baseline photochemistry. Here we show that such agreement can be deceptive and that a yet unidentified oxidant is needed to explain the photochemical conditions observed at 40°-60° S over the Atlantic Ocean.

  7. The traveltime holographic principle

    NASA Astrophysics Data System (ADS)

    Huang, Yunsong; Schuster, Gerard T.

    2015-01-01

    Fermat's interferometric principle is used to compute interior transmission traveltimes τpq from exterior transmission traveltimes τsp and τsq. Here, the exterior traveltimes are computed for sources s on a boundary B that encloses a volume V of interior points p and q. Once the exterior traveltimes are computed, no further ray tracing is needed to calculate the interior times τpq. Therefore this interferometric approach can be more efficient than explicitly computing interior traveltimes τpq by ray tracing. Moreover, the memory requirement of the traveltimes is reduced by one dimension, because the boundary B is of one fewer dimension than the volume V. An application of this approach is demonstrated with interbed multiple (IM) elimination. Here, the IMs in the observed data are predicted from the migration image and are subsequently removed by adaptive subtraction. This prediction is enabled by the knowledge of interior transmission traveltimes τpq computed according to Fermat's interferometric principle. We denote this principle as the `traveltime holographic principle', by analogy with the holographic principle in cosmology where information in a volume is encoded on the region's boundary.

  8. Applying the four principles.

    PubMed

    Macklin, R

    2003-10-01

    Gillon is correct that the four principles provide a sound and useful way of analysing moral dilemmas. As he observes, the approach using these principles does not provide a unique solution to dilemmas. This can be illustrated by alternatives to Gillon's own analysis of the four case scenarios. In the first scenario, a different set of factual assumptions could yield a different conclusion about what is required by the principle of beneficence. In the second scenario, although Gillon's conclusion is correct, what is open to question is his claim that what society regards as the child's best interest determines what really is in the child's best interest. The third scenario shows how it may be reasonable for the principle of beneficence to take precedence over autonomy in certain circumstances, yet like the first scenario, the ethical conclusion relies on a set of empirical assumptions and predictions of what is likely to occur. The fourth scenario illustrates how one can draw different conclusions based on the importance given to the precautionary principle. PMID:14519836

  9. Full-field transmission-type angle-deviation optical microscope with reflectivity-height transformation

    PubMed Central

    Chiu, Ming-Hung; Tan, Chen-Tai; Tsai, Ming-Hung; Yang, Ya-Hsin

    2015-01-01

    This full-field transmission-type three-dimensional (3D) optical microscope is constructed based on the angle deviation method (ADM) and the algorithm of reflectivity-height transformation (RHT). The surface height is proportional to the deviation angle of light passing through the object. The angle deviation and surface height can be measured based on the reflectivity closed to the critical angle using a parallelogram prism and two CCDs. PMID:26504645

  10. Spaceborne receivers: Basic principles

    NASA Technical Reports Server (NTRS)

    Stacey, J. M.

    1984-01-01

    The underlying principles of operation of microwave receivers for space observations of planetary surfaces were examined. The design philosophy of the receiver as it is applied to operate functionally as an efficient receiving system, the principle of operation of the key components of the receiver, and the important differences among receiver types are explained. The operating performance and the sensitivity expectations for both the modulated and total power receiver configurations are outlined. The expressions are derived from first principles and are developed through the important intermediate stages to form practicle and easily applied equations. The transfer of thermodynamic energy from point to point within the receiver is illustrated. The language of microwave receivers is applied statistics.

  11. Nonlinear elastic effects on the energy flux deviation of ultrasonic waves in gr/ep composites

    NASA Technical Reports Server (NTRS)

    Prosser, William H.; Kriz, R. D.; Fitting, Dale W.

    1992-01-01

    The effects of nonlinear elasticity on energy flux deviation in undirectional gr/ep composites are examined. The shift in the flux deviation is modeled using acoustoelasticity theory and the second- and third-order elastic stiffness coefficients for T300/5208 gr/ep. Two conditions of applied uniaxial stress are considered. In the first case, the direction of applied uniaxial stress was along the fiber axis (x3), while in the second case it was perpendicular to the fiber axis along the laminate stacking direction (x1). For both conditions, the change in the energy flux deviation angle from the condition of zero applied stress is computed over the range of propagation directions of 0 to 60 deg from the fiber axis at two-degree intervals. A positive flux deviation angle implies the energy deviates away from the fiber direction toward the x1 axis, while a negative deviation means that the energy deviates toward the fibers. Over this range of fiber orientation angles, the energy of the quasi-longitudinal and pure mode transverse waves deviates toward the fibers, while that of the quasi-transverse mode deviates away from the fibers.

  12. Minimization of deviations of gear real tooth surfaces determined by coordinate measurements

    NASA Technical Reports Server (NTRS)

    Litvin, F. L.; Kuan, C.; Wang, J.-C.; Handschuh, R. F.; Masseth, J.; Maruyama, N.

    1992-01-01

    The deviations of a gear's real tooth surface from the theoretical surface are determined by coordinate measurements at the grid of the surface. A method was developed to transform the deviations from Cartesian coordinates to those along the normal at the measurement locations. Equations are derived that relate the first order deviations with the adjustment to the manufacturing machine-tool settings. The deviations of the entire surface are minimized. The minimization is achieved by application of the least-square method for an overdetermined system of linear equations. The proposed method is illustrated with a numerical example for hypoid gear and pinion.

  13. Teaching/learning principles

    NASA Technical Reports Server (NTRS)

    Hankins, D. B.; Wake, W. H.

    1981-01-01

    The potential remote sensing user community is enormous, and the teaching and training tasks are even larger; however, some underlying principles may be synthesized and applied at all levels from elementary school children to sophisticated and knowledgeable adults. The basic rules applying to each of the six major elements of any training course and the underlying principle involved in each rule are summarized. The six identified major elements are: (1) field sites for problems and practice; (2) lectures and inside study; (3) learning materials and resources (the kit); (4) the field experience; (5) laboratory sessions; and (6) testing and evaluation.

  14. Itch Management: General Principles.

    PubMed

    Misery, Laurent

    2016-01-01

    Like pain, itch is a challenging condition that needs to be managed. Within this setting, the first principle of itch management is to get an appropriate diagnosis to perform an etiology-oriented therapy. In several cases it is not possible to treat the cause, the etiology is undetermined, there are several causes, or the etiological treatment is not effective enough to alleviate itch completely. This is also why there is need for symptomatic treatment. In all patients, psychological support and associated pragmatic measures might be helpful. General principles and guidelines are required, yet patient-centered individual care remains fundamental. PMID:27578069

  15. Oil-water flow in vertical and deviated wells

    NASA Astrophysics Data System (ADS)

    Flores, Jose Gonzalo

    1997-08-01

    Oil-water flow in vertical and inclined pipes has been investigated theoretically and experimentally to identify and characterize the flow patterns, and to model the flow pattern transitions, holdup and pressure drop for conditions pertinent to oil-water producing wells. A comprehensive new oil-water flow pattern classification is proposed based on data acquired in a transparent test section (2 in. ID, 51 ft long) using a mineral oil and water (ρo/ρw = 0.85, μo/μw = 20.0 and σo-w = 33.5 dyne/cm at 90oF). The tests covered inclination angles of 90o, 75o, 60o and 45o from the horizontal. The oil-water flow patterns have been grouped into two major categories based on the status of the continuous phase, including water dominated and oil dominated flow patterns. Water dominated flow patterns generally show significant slippage but relatively low frictional pressure gradients. In contrast, oil dominated flow patterns show negligible slippage but significantly large frictional pressure gradients. Six flow patterns have been characterized in vertical flow, three were water dominated and three were oil dominated. In inclined flow there were also three water dominated flow patterns, three oil dominated and a transitional flow pattern. Flow pattern maps for each of the tested inclination angles are presented. Flow parameters, including frictional pressure drop, holdup and spatial phase distribution are functions of the oil-water flow patterns and can be effectively used in flow pattern identification. A newly designed conductance probe assisted significantly in the objective identification of the oil-water flow patterns. Mechanistic models are proposed to predict oil-water flow pattern transitions, and to calculate water holdup and pressure drop in vertical wells. The transitions to very fine dispersed flows were evaluated by combining the turbulent kinetic energy with the surface free energy of the droplets, while the transition to churn flow was predicted based on the

  16. The August Krogh principle applies to plants

    NASA Technical Reports Server (NTRS)

    Wayne, R.; Staves, M. P.

    1996-01-01

    The Krogh principle refers to the use of a large number of animals to study the large number of physiological problems, rather than limiting study to a particular organism for all problems. There may be organisms that are more suited to study of a particular problem than others. This same principle applies to plants. The authors are concerned with the recent trend in plant biology of using Arabidopsis thaliana as the "organism of choice." Arabidopsis is an excellent organism for molecular genetic research, but other plants are superior models for other research areas of plant biology. The authors present examples of the successful use of the Krogh principle in plant cell biology research, emphasizing the particular characteristics of the selected research organisms that make them the appropriate choice.

  17. Reprographic Principles Made Easy.

    ERIC Educational Resources Information Center

    Young, J. B.

    Means for reproducing graphic materials are explained. There are several types of processes: those using light sensitive material, those using heat sensitive material, those using photo conductive materials (electrophotography), and duplicating processes using ink. For each of these, the principles behind them are explained, the necessary…

  18. PRINCIPLES OF WATER FILTRATION

    EPA Science Inventory

    This paper reviews principles involved in the processes commonly used to filter drinking water for public water systems. he most common approach is to chemically pretreat water and filter it through a deep (2-1/2 to 3 ft) bed of granuu1ar media (coal or sand or combinations of th...

  19. Extended Mach Principle.

    ERIC Educational Resources Information Center

    Rosen, Joe

    1981-01-01

    Discusses the meaning of symmetry of the laws of physics and symmetry of the universe and the connection between symmetries and asymmetries of the laws of physics and those of the universe. An explanation of Hamilton's principle is offered. The material is suitable for informal discussions with students. (Author/SK)

  20. Basic Comfort Heating Principles.

    ERIC Educational Resources Information Center

    Dempster, Chalmer T.

    The material in this beginning book for vocational students presents fundamental principles needed to understand the heating aspect of the sheet metal trade and supplies practical experience to the student so that he may become familiar with the process of determining heat loss for average structures. Six areas covered are: (1) Background…

  1. Matters of Principle.

    ERIC Educational Resources Information Center

    Martz, Carlton

    1999-01-01

    This issue of "Bill of Rights in Action" looks at individuals who have stood on principle against authority or popular opinion. The first article investigates John Adams and his defense of British soldiers at the Boston Massacre trials. The second article explores Archbishop Thomas Becket's fatal conflict with England's King Henry II. The final…

  2. Principles of Biomedical Ethics

    PubMed Central

    Athar, Shahid

    2012-01-01

    In this presentation, I will discuss the principles of biomedical and Islamic medical ethics and an interfaith perspective on end-of-life issues. I will also discuss three cases to exemplify some of the conflicts in ethical decision-making. PMID:23610498

  3. Fermat's Principle Revisited.

    ERIC Educational Resources Information Center

    Kamat, R. V.

    1991-01-01

    A principle is presented to show that, if the time of passage of light is expressible as a function of discrete variables, one may dispense with the more general method of the calculus of variations. The calculus of variations and the alternative are described. The phenomenon of mirage is discussed. (Author/KR)

  4. Design Principles of the ESCOT Math Environments.

    ERIC Educational Resources Information Center

    Underwood, Jody S.; Hoadley, Chris; DiGiano, Chris; Stohl, Hollylynne; Hollebrands, Karen

    This paper describes the Educational Software Components of Tomorrow (ESCOT) project. The focus of the project was on principles that support problem-solving and learner-centered design issues, and the purpose was to garner lessons from a large educational software development project to share with the learning sciences and other interested…

  5. 48 CFR 501.404-71 - Deviations to the nonregulatory GSAM.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Deviations to the nonregulatory GSAM. 501.404-71 Section 501.404-71 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION GENERAL GENERAL SERVICES ADMINISTRATION ACQUISITION REGULATION SYSTEM Deviations From the FAR...

  6. 48 CFR 1401.405 - Deviations pertaining to treaties and executive agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the FAR and DIAR 1401.405 Deviations pertaining to treaties and executive agreements. (a) The Director, PAM, is responsible for transmitting to the FAR Secretariat the information required in FAR 1.405(d). (b) For deviations not authorized by FAR 1.405(b) or (c), the Director, PAM, shall process...

  7. 14 CFR 119.57 - Obtaining deviation authority to perform an emergency operation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... supplies for the protection of life or property; and (2) The Administrator finds that a deviation is... to the certificate holder's operations specifications; or (2) If the nature of the emergency does not... deviation orally; and (ii) The certificate holder shall provide documentation describing the nature of...

  8. 21 CFR 600.14 - Reporting of biological product deviations by licensed manufacturers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Reporting of biological product deviations by... HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL PRODUCTS: GENERAL Establishment Standards § 600.14 Reporting of biological product deviations by licensed manufacturers. (a) Who must report...

  9. 21 CFR 600.14 - Reporting of biological product deviations by licensed manufacturers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Reporting of biological product deviations by... HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL PRODUCTS: GENERAL Establishment Standards § 600.14 Reporting of biological product deviations by licensed manufacturers. (a) Who must report...

  10. 21 CFR 600.14 - Reporting of biological product deviations by licensed manufacturers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Reporting of biological product deviations by... HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS BIOLOGICAL PRODUCTS: GENERAL Establishment Standards § 600.14 Reporting of biological product deviations by licensed manufacturers. (a) Who must report...

  11. 14 CFR 99.17 - Deviation from flight plans and ATC clearances and instructions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Deviation from flight plans and ATC clearances and instructions. 99.17 Section 99.17 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SECURITY CONTROL OF AIR TRAFFIC General § 99.17 Deviation from...

  12. Quark condensate and deviations from string-like behaviour of meson spectra

    NASA Astrophysics Data System (ADS)

    Afonin, S. S.

    2003-12-01

    I analyze the hypothesis that deviations from the linear meson mass spectra appear due to the dynamical chiral symmetry breaking in QCD. It is shown that the linear mass spectrum for the light, non-strange vector and axial-vector mesons is then parametrized by the constant fπ, being successful phenomenologically. The toy model for deviations from linearity is proposed.

  13. Defending the beauty of the Invariance Principle

    NASA Astrophysics Data System (ADS)

    Barkana, Itzhak

    2014-01-01

    Customary stability analysis methods for nonlinear nonautonomous systems seem to require a strict condition of uniform continuity. Although extensions of LaSalle's Invariance Principle to nonautonomous systems that mitigate this condition have been available for a long time, they have remained surprisingly unknown or open to misinterpretations. The large scope of the Principle might have misled the prospective users and its application to Control problems has been received with amazing yet clear uneasiness. Counterexamples have been used in order to claim that the Invariance Principle cannot be applied to nonlinear nonautonomous systems. Because the original formulation of the Invariance Principle still imposes conditions that are not necessarily needed, this paper presents a new Invariance Principle that further mitigates previous conditions and thus further expands the scope of stability analysis. A brief comparative review of various alternatives to stability analysis of nonautonomous nonlinear systems and their implications is also presented in order to illustrate that thorough analysis of same examples may actually confirm the efficiency of the Invariance Principle approach when dealing with stability of nonautonomous nonlinear systems problems that may look difficult or even unsolvable otherwise.

  14. Illusory shadow person causing paradoxical gaze deviations during temporal lobe seizures.

    PubMed

    Zijlmans, M; van Eijsden, P; Ferrier, C H; Kho, K H; van Rijen, P C; Leijten, F S S

    2009-06-01

    Generally, activation of the frontal eye field during seizures can cause versive (forced) gaze deviation, while non-versive head deviation is hypothesised to result from ictal neglect after inactivation of the ipsilateral temporo-parietal area. Almost all non-versive head deviations occurring during temporal lobe seizures are directed to the side of seizure onset, so in derogatory cases it is worth while explaining the paradoxical event. We present a patient with a paradoxical direction of gaze deviation during temporal lobe seizures with an unexpected explanation. Electrocortical stimulation of the temporo-parieto-occipital junction elicited an irrepressible urge to look towards an illusory shadow person besides the patient. Paradoxical non-versive gaze deviations in temporal lobe seizures may be due to illusory experiences masked by postictal amnesia. PMID:19448096

  15. Secondary flow spanwise deviation model for the stators of NASA middle compressor stages

    NASA Technical Reports Server (NTRS)

    Roberts, W. B.; Sandercock, D. M.

    1984-01-01

    A model of the spanwise variation of deviation for stator blades is presented. Deviation is defined as the difference between the passage mean flow angle and the metal angle at the outlet of a blade element of an axial compressor stage. The variation of deviation is taken as the difference above or below that predicted by blade element, (i.e., two-dimensional) theory at any spanwise location. The variation of deviation is dependent upon the blade camber, solidity and inlet boundary layer thickness at the hub or tip end-wall, and the blade channel aspect ratio. If these parameters are known or can be calculated, the model provides a reasonable approximation of the spanwise variation of deviation for most compressor middle stage stators operating at subsonic inlet Mach numbers.

  16. The role of septal surgery in management of the deviated nose.

    PubMed

    Foda, Hossam M T

    2005-02-01

    The deviated nose represents a complex cosmetic and functional problem. Septal surgery plays a central role in the successful management of the externally deviated nose. This study included 260 patients seeking rhinoplasty to correct external nasal deviations; 75 percent of them had various degrees of nasal obstruction. Septal surgery was necessary in 232 patients (89 percent), not only to improve breathing but also to achieve a straight, symmetrical, external nose as well. A graduated surgical approach was adopted to allow correction of the dorsal and caudal deviations of the nasal septum without weakening its structural support to the dorsum or nasal tip. The approach depended on full mobilization of deviated cartilage, followed by straightening of the cartilage and its fixation in the corrected position by using bony splinting grafts through an external rhinoplasty approach. PMID:15692343

  17. Reliable detection of fluence anomalies in EPID-based IMRT pretreatment quality assurance using pixel intensity deviations

    SciTech Connect

    Gordon, J. J.; Gardner, J. K.; Wang, S.; Siebers, J. V.

    2012-08-15

    Purpose: This work uses repeat images of intensity modulated radiation therapy (IMRT) fields to quantify fluence anomalies (i.e., delivery errors) that can be reliably detected in electronic portal images used for IMRT pretreatment quality assurance. Methods: Repeat images of 11 clinical IMRT fields are acquired on a Varian Trilogy linear accelerator at energies of 6 MV and 18 MV. Acquired images are corrected for output variations and registered to minimize the impact of linear accelerator and electronic portal imaging device (EPID) positioning deviations. Detection studies are performed in which rectangular anomalies of various sizes are inserted into the images. The performance of detection strategies based on pixel intensity deviations (PIDs) and gamma indices is evaluated using receiver operating characteristic analysis. Results: Residual differences between registered images are due to interfraction positional deviations of jaws and multileaf collimator leaves, plus imager noise. Positional deviations produce large intensity differences that degrade anomaly detection. Gradient effects are suppressed in PIDs using gradient scaling. Background noise is suppressed using median filtering. In the majority of images, PID-based detection strategies can reliably detect fluence anomalies of {>=}5% in {approx}1 mm{sup 2} areas and {>=}2% in {approx}20 mm{sup 2} areas. Conclusions: The ability to detect small dose differences ({<=}2%) depends strongly on the level of background noise. This in turn depends on the accuracy of image registration, the quality of the reference image, and field properties. The longer term aim of this work is to develop accurate and reliable methods of detecting IMRT delivery errors and variations. The ability to resolve small anomalies will allow the accuracy of advanced treatment techniques, such as image guided, adaptive, and arc therapies, to be quantified.

  18. Two universal physical principles shape the power-law statistics of real-world networks

    PubMed Central

    Lorimer, Tom; Gomez, Florian; Stoop, Ruedi

    2015-01-01

    The study of complex networks has pursued an understanding of macroscopic behaviour by focusing on power-laws in microscopic observables. Here, we uncover two universal fundamental physical principles that are at the basis of complex network generation. These principles together predict the generic emergence of deviations from ideal power laws, which were previously discussed away by reference to the thermodynamic limit. Our approach proposes a paradigm shift in the physics of complex networks, toward the use of power-law deviations to infer meso-scale structure from macroscopic observations. PMID:26202858

  19. Two universal physical principles shape the power-law statistics of real-world networks

    NASA Astrophysics Data System (ADS)

    Lorimer, Tom; Gomez, Florian; Stoop, Ruedi

    2015-07-01

    The study of complex networks has pursued an understanding of macroscopic behaviour by focusing on power-laws in microscopic observables. Here, we uncover two universal fundamental physical principles that are at the basis of complex network generation. These principles together predict the generic emergence of deviations from ideal power laws, which were previously discussed away by reference to the thermodynamic limit. Our approach proposes a paradigm shift in the physics of complex networks, toward the use of power-law deviations to infer meso-scale structure from macroscopic observations.

  20. Sea level rise of semi-enclosed basins: deviation of Adriatic and Baltic sea level from the mean global value.

    NASA Astrophysics Data System (ADS)

    Scarascia, Luca; Lionello, Piero

    2015-04-01

    Future sea level rise (SL), which represents today one of the major threats that are caused by climate change, will not be uniform. Regional differences are crucial for 40% of the world population, which is located in the coastal zone. To explore the mechanisms linking regional SL to climate variables is very important in order to provide reliable future projections. This study focuses on two semi-enclosed basins, the Adriatic and Baltic Sea and investigates the deviation of their SL from the mean global value. In fact, past deviations of the SL of these two basins from the global value have been observed and can be attributed to large scale factors (such as teleconnections) and regional factors, such as the inverse barometric effect, the wind stress, the thermosteric and halosteric effects. The final goal of this work is to assess to which extent the Adriatic and Baltic SL will depart from the mean global value in the next decades and at the end of 21st century. This is achieved by analyzing deviations of the mean SL of the Baltic and Adriatic Sea from the global mean SL during the 20th century and investigating which factors can explain such deviations. A multivariate linear regression model is built and used to describe the link between three large scale climate variables which are used as predictors (mean sea level pressure, surface air temperature and precipitation), and the regional SL deviation (the predictand), computed as the difference between the regional and the global SL. At monthly scale this linear regression model provides a good reconstruction of the past variability in the cold season during which it explains 60%-70% of the variance. Summer reconstruction is substantially less successful and it represents presently the main limit of the model skill. This linear regression model, forced by predictors extracted from CMIP5 multi-model simulations, is used to provide projections of SL in the Adriatic and Baltic Sea. On the basis of the projections

  1. The Impact of Advanced Technologies on Treatment Deviations in Radiation Treatment Delivery

    SciTech Connect

    Marks, Lawrence B. Light, Kim L.; Hubbs, Jessica L.; Georgas, Debra L.; Jones, Ellen L.; Wright, Melanie C.; Willett, Christopher G.; Yin Fangfang

    2007-12-01

    Purpose: To assess the impact of new technologies on deviation rates in radiation therapy (RT). Methods and Materials: Treatment delivery deviations in RT were prospectively monitored during a time of technology upgrade. In January 2003, our department had three accelerators, none with 'modern' technologies (e.g., without multileaf collimators [MLC]). In 2003 to 2004, we upgraded to five new accelerators, four with MLC, and associated advanced capabilities. The deviation rates among patients treated on 'high-technology' versus 'low-technology' machines (defined as those with vs. without MLC) were compared over time using the two-tailed Fisher's exact test. Results: In 2003, there was no significant difference between the deviation rate in the 'high-technology' versus 'low-technology' groups (0.16% vs. 0.11%, p = 0.45). In 2005 to 2006, the deviation rate for the 'high-technology' groups was lower than the 'low-technology' (0.083% vs. 0.21%, p = 0.009). This difference was caused by a decline in deviations on the 'high-technology' machines over time (p = 0.053), as well as an unexpected trend toward an increase in deviations over time on the 'low-technology' machines (p = 0.15). Conclusions: Advances in RT delivery systems appear to reduce the rate of treatment deviations. Deviation rates on 'high-technology' machines with MLC decline over time, suggesting a learning curve after the introduction of new technologies. Associated with the adoption of 'high-technology' was an unexpected increase in the deviation rate with 'low-technology' approaches, which may reflect an over-reliance on tools inherent to 'high-technology' machines. With the introduction of new technologies, continued diligence is needed to ensure that staff remain proficient with 'low-technology' approaches.

  2. Positronium, antihydrogen, light, and the equivalence principle

    NASA Astrophysics Data System (ADS)

    Karshenboim, Savely G.

    2016-07-01

    While discussing a certain generic difference in effects of gravity on particles and antiparticles, various neutral particles (i.e. the particles which are identical with their antiparticles) could be a perfect probe. One such neutral particles is the positronium atom, which has been available for precision experiments for a few decades. The other important neutral particle is the photon. Behavior of light in the presence of a gravitational field has been the key both to build and develop the theory of general relativity and to verify it experimentally. The very idea of antigravity for antimatter strongly contradicts both the principles of general relativity and its experimentally verified consequences. Consideration of existing experimental results on photons and positrons makes antigravity impossible and leads to a conclusion that the deviation of the ratio of acceleration of the free fall of particles and antiparticles cannot exceed the level of 1× {10}-5.

  3. Principles of Natural Photosynthesis.

    PubMed

    Krewald, Vera; Retegan, Marius; Pantazis, Dimitrios A

    2016-01-01

    Nature relies on a unique and intricate biochemical setup to achieve sunlight-driven water splitting. Combined experimental and computational efforts have produced significant insights into the structural and functional principles governing the operation of the water-oxidizing enzyme Photosystem II in general, and of the oxygen-evolving manganese-calcium cluster at its active site in particular. Here we review the most important aspects of biological water oxidation, emphasizing current knowledge on the organization of the enzyme, the geometric and electronic structure of the catalyst, and the role of calcium and chloride cofactors. The combination of recent experimental work on the identification of possible substrate sites with computational modeling have considerably limited the possible mechanistic pathways for the critical O-O bond formation step. Taken together, the key features and principles of natural photosynthesis may serve as inspiration for the design, development, and implementation of artificial systems. PMID:26099285

  4. Common Principles and Multiculturalism

    PubMed Central

    Zahedi, Farzaneh; Larijani, Bagher

    2009-01-01

    Judgment on rightness and wrongness of beliefs and behaviors is a main issue in bioethics. Over centuries, big philosophers and ethicists have been discussing the suitable tools to determine which act is morally sound and which one is not. Emerging the contemporary bioethics in the West has resulted in a misconception that absolute westernized principles would be appropriate tools for ethical decision making in different cultures. We will discuss this issue by introducing a clinical case. Considering various cultural beliefs around the world, though it is not logical to consider all of them ethically acceptable, we can gather on some general fundamental principles instead of going to the extremes of relativism and absolutism. Islamic teachings, according to the presented evidence in this paper, fall in with this idea. PMID:23908720

  5. Deviation of Long-Period Tides from Equilibrium: Kinematics and Geostrophy

    NASA Technical Reports Server (NTRS)

    Egbert, Gary D.; Ray, Richard D.

    2003-01-01

    New empirical estimates of the long-period fortnightly (Mf) tide obtained from TOPEX/Poseidon (T/P) altimeter data confirm significant basin-scale deviations from equilibrium. Elevations in the low-latitude Pacific have reduced amplitude and lag those in the Atlantic by 30 deg or more. These interbasin amplitude and phase variations are robust features that are reproduced by numerical solutions of the shallow-water equations, even for a constant-depth ocean with schematic interconnected rectangular basins. A simplified analytical model for cooscillating connected basins also reproduces the principal features observed in the empirical solutions. This simple model is largely kinematic. Zonally averaged elevations within a simple closed basin would be nearly in equilibrium with the gravitational potential, except for a constant offset required to conserve mass. With connected basins these offsets are mostly eliminated by interbasin mass flux. Because of rotation, this flux occurs mostly in a narrow boundary layer across the mouth and at the western edge of each basin, and geostrophic balance in this zone supports small residual offsets (and phase shifts) between basins. The simple model predicts that this effect should decrease roughly linearly with frequency, a result that is confirmed by numerical modeling and empirical T/P estimates of the monthly (Mm) tidal constituent. This model also explains some aspects of the anomalous nonisostatic response of the ocean to atmospheric pressure forcing at periods of around 5 days.

  6. The dustier early-type galaxies deviate from late-type galaxies' scaling relations

    NASA Astrophysics Data System (ADS)

    Lianou, S.; Xilouris, E.; Madden, S. C.; Barmby, P.

    2016-09-01

    Several dedicated surveys focusing on early-type galaxies (ETGs) reveal that significant fractions of them are detectable in all interstellar medium phases studied to date. We select ETGs from the Herschel Reference Survey that have both far-infrared Herschel and either H I or CO detection (or both). We derive their star formation rates (SFRs), stellar masses and dust masses via modelling their spectral energy distributions. We combine these with literature information on their atomic and molecular gas properties, in order to relate their star formation, total gas mass and dust mass on global scales. The ETGs deviate from the dust mass-SFR relation and the Schmidt-Kennicutt relation that SDSS star-forming galaxies define: compared to SDSS galaxies, ETGs have more dust at the same SFR, or less SFR at the same dust mass. When placing them in the M⋆-SFR plane, ETGs show a much lower specific SFR as compared to normal star-forming galaxies. ETGs show a large scatter compared to the Schmidt-Kennicutt relation found locally within our Galaxy, extending to lower SFRs and gas mass surface densities. Using an ETG's SFR and the Schmidt-Kennicutt law to predict its gas mass leads to an underestimate. ETGs have similar observed-gas-to-modelled-dust mass ratios to star-forming galaxies of the same stellar mass, as well as they exhibit a similar scatter.

  7. Pathological torsional eye deviation during voluntary saccades: a violation of Listing's law.

    PubMed Central

    Helmchen, C; Glasauer, S; Büttner, U

    1997-01-01

    BACKGROUND: Under normal conditions, there are no torsional eye movements during voluntary saccades when the head is stationary (Listing's law). METHODS AND RESULTS: Using dual search coils for three dimensional eye movement recordings, a patient is reported who had direction specific rapid deviations of torsional eye position (up to 10.5 degrees) during voluntary saccades followed by a slow exponential torsional drift after the end of the saccade ("blip") towards the initial torsional eye position. In the absence of spontaneous nystagmus, this transient torsion means a violation of Listing's law for voluntary saccades and was associated with a lesion involving the cerebellar vermis, its deep nuclei, and the dorsolateral medulla. Amplitudes of the blip were larger for ipsilesional (hypermetric) than contralesional (hypometric) horizontal saccades. For comparison transient torsion during and after saccades was also examined in six normal subjects. Using the same in vivo calibration, there were no blips larger than 1.2 degrees in any of them. CONCLUSION: Transient torsion with large amplitudes can be clinically seen on bedside examination and might thus be a new clinical sign in the diagnosis of saccadic disorders. Images PMID:9069480

  8. A correspondence principle

    NASA Astrophysics Data System (ADS)

    Hughes, Barry D.; Ninham, Barry W.

    2016-02-01

    A single mathematical theme underpins disparate physical phenomena in classical, quantum and statistical mechanical contexts. This mathematical "correspondence principle", a kind of wave-particle duality with glorious realizations in classical and modern mathematical analysis, embodies fundamental geometrical and physical order, and yet in some sense sits on the edge of chaos. Illustrative cases discussed are drawn from classical and anomalous diffusion, quantum mechanics of single particles and ideal gases, quasicrystals and Casimir forces.

  9. Pauli Exclusion Principle

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    A principle of quantum theory, devised in 1925 by Wolfgang Pauli (1900-58), which states that no two fermions may exist in the same quantum state. The quantum state of a particle is defined by a set of numbers that describe quantities such as energy, angular momentum and spin. Fermions are particles such as quarks, protons, neutrons and electrons, that have spin = ½ (in units of h/2π, where h is ...

  10. Computational principles of memory.

    PubMed

    Chaudhuri, Rishidev; Fiete, Ila

    2016-03-01

    The ability to store and later use information is essential for a variety of adaptive behaviors, including integration, learning, generalization, prediction and inference. In this Review, we survey theoretical principles that can allow the brain to construct persistent states for memory. We identify requirements that a memory system must satisfy and analyze existing models and hypothesized biological substrates in light of these requirements. We also highlight open questions, theoretical puzzles and problems shared with computer science and information theory. PMID:26906506

  11. Principles of nuclear geology

    SciTech Connect

    Aswathanarayana, U.

    1985-01-01

    This book treats the basic principles of nuclear physics and the mineralogy, geochemistry, distribution and ore deposits of uranium and thorium. The application of nuclear methodology in radiogenic heat and thermal regime of the earth, radiometric prospecting, isotopic age dating, stable isotopes and cosmic-ray produced isotopes is covered. Geological processes, such as metamorphic chronology, petrogenesis, groundwater movement, and sedimentation rate are focussed on.

  12. Heisenberg's observability principle

    NASA Astrophysics Data System (ADS)

    Wolff, Johanna

    2014-02-01

    Werner Heisenberg's 1925 paper 'Quantum-theoretical re-interpretation of kinematic and mechanical relations' marks the beginning of quantum mechanics. Heisenberg famously claims that the paper is based on the idea that the new quantum mechanics should be 'founded exclusively upon relationships between quantities which in principle are observable'. My paper is an attempt to understand this observability principle, and to see whether its employment is philosophically defensible. Against interpretations of 'observability' along empiricist or positivist lines I argue that such readings are philosophically unsatisfying. Moreover, a careful comparison of Heisenberg's reinterpretation of classical kinematics with Einstein's argument against absolute simultaneity reveals that the positivist reading does not fit with Heisenberg's strategy in the paper. Instead the appeal to observability should be understood as a specific criticism of the causal inefficacy of orbital electron motion in Bohr's atomic model. I conclude that the tacit philosophical principle behind Heisenberg's argument is not a positivistic connection between observability and meaning, but the idea that a theory should not contain causally idle wheels.

  13. Optimality Principles of Undulatory Swimming

    NASA Astrophysics Data System (ADS)

    Nangia, Nishant; Bale, Rahul; Patankar, Neelesh

    2015-11-01

    A number of dimensionless quantities derived from a fish's kinematic and morphological parameters have been used to describe the hydrodynamics of swimming. In particular, body/caudal fin swimmers have been found to swim within a relatively narrow range of these quantities in nature, e.g., Strouhal number or the optimal specific wavelength. It has been hypothesized or shown that these constraints arise due to maximization of swimming speed, efficiency, or cost of transport in certain domains of this large dimensionless parameter space. Using fully resolved simulations of undulatory patterns, we investigate the existence of various optimality principles in fish swimming. Using scaling arguments, we relate various dimensionless parameters to each other. Based on these findings, we make design recommendations on how kinematic parameters for a swimming robot or vehicle should be chosen. This work is supported by NSF Grants CBET-0828749, CMMI-0941674, CBET-1066575 and the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1324585.

  14. History and Principles of Humanitarian Action.

    PubMed

    Rysaback-Smith, Heather

    2015-10-01

    Humanitarian aid has been present in some form throughout human history, yet the modern concept of humanitarian aid has only truly emerged since the later half of the 20th century. Through a complex progression of world events and largely brought about in response to armed conflict, modern humanitarian aid is provided by a multitude of organizations and actors. The purpose of this chapter is to provide a brief overview of the history of humanitarian action, a review of the principles of humanitarian aid and an overview of the major documents which delineate those principles. PMID:27437525

  15. Mechanisms that Amplify, Attenuate and Deviate Glacier Response to Climate Change in Central East Greenland. (Invited)

    NASA Astrophysics Data System (ADS)

    Jiskoot, H.

    2013-12-01

    A multidecadal review of glacier fluctuations and case-studies of glacier processes and environments in central East Greenland will be used to demonstrate Mechanisms that Amplify, Attenuate and Deviate glacier response to climate forcings (MAAD). The different spatial and temporal scales at which MAAD affect mass balance and ice flow may complicate interpretation and longterm extrapolation of glacier response to climate change. A framework of MAAD characterisation and best-practice for interpreting climate signals while taking into account MAAD will be proposed. Glaciers in the Watkins Bjerge, Geikie Plateau and Stauning Alps regions of central East Greenland (68°-72°N) contain about 50000 km2 of glacierized area peripheral to the Greenland Ice Sheet. Within the region, large north-south and coast-inland climatic gradients, as well as complicated topography and glacier dynamics, result in discrepant glacier behaviour. Average retreat rates have doubled from about 2 to 4 km2 a-1 between the late 20th and early 21st centuries. However, glaciers terminating along the Atlantic coast display two times the retreat, thinning, and acceleration rates compared to glaciers terminating in inland fjords or on land. Despite similar climatic forcing variable glacier behaviour is apparent: individual glacier length change ranges from +57 m a-1 to -428 m a-1, though most retreat -20 to -100 m a-1. Interacting dynamic, mass balance and glacio-morphological mechanisms can amplify, attenuate or deviate glacier response (MAAD) to climate change, thus complicating the climatological interpretation of glacier length, area, and thickness changes. East Greenland MAAD include a range of common positive and negative feedback mechanisms in surface mass balance and terminus and subglacial boundary conditions affecting ice flow, but also mechanisms that have longterm or delayed effects. Certain MAAD may affect glacier change interpretation on multiple timescales: e.g. surging glaciers do not

  16. Generalized convective quasi-equilibrium principle

    NASA Astrophysics Data System (ADS)

    Yano, Jun-Ichi; Plant, Robert S.

    2016-03-01

    A generalization of Arakawa and Schubert's convective quasi-equilibrium principle is presented for a closure formulation of mass-flux convection parameterization. The original principle is based on the budget of the cloud work function. This principle is generalized by considering the budget for a vertical integral of an arbitrary convection-related quantity. The closure formulation includes Arakawa and Schubert's quasi-equilibrium, as well as both CAPE and moisture closures as special cases. The formulation also includes new possibilities for considering vertical integrals that are dependent on convective-scale variables, such as the moisture within convection. The generalized convective quasi-equilibrium is defined by a balance between large-scale forcing and convective response for a given vertically-integrated quantity. The latter takes the form of a convolution of a kernel matrix and a mass-flux spectrum, as in the original convective quasi-equilibrium. The kernel reduces to a scalar when either a bulk formulation is adopted, or only large-scale variables are considered within the vertical integral. Various physical implications of the generalized closure are discussed. These include the possibility that precipitation might be considered as a potentially-significant contribution to the large-scale forcing. Two dicta are proposed as guiding physical principles for the specifying a suitable vertically-integrated quantity.

  17. Differential processing of melodic, rhythmic and simple tone deviations in musicians--an MEG study.

    PubMed

    Lappe, Claudia; Lappe, Markus; Pantev, Christo

    2016-01-01

    Rhythm and melody are two basic characteristics of music. Performing musicians have to pay attention to both, and avoid errors in either aspect of their performance. To investigate the neural processes involved in detecting melodic and rhythmic errors from auditory input we tested musicians on both kinds of deviations in a mismatch negativity (MMN) design. We found that MMN responses to a rhythmic deviation occurred at shorter latencies than MMN responses to a melodic deviation. Beamformer source analysis showed that the melodic deviation activated superior temporal, inferior frontal and superior frontal areas whereas the activation pattern of the rhythmic deviation focused more strongly on inferior and superior parietal areas, in addition to superior temporal cortex. Activation in the supplementary motor area occurred for both types of deviations. We also recorded responses to similar pitch and tempo deviations in a simple, non-musical repetitive tone pattern. In this case, there was no latency difference between the MMNs and cortical activation was smaller and mostly limited to auditory cortex. The results suggest that prediction and error detection of musical stimuli in trained musicians involve a broad cortical network and that rhythmic and melodic errors are processed in partially different cortical streams. PMID:26436712

  18. Nonasymptotic homogenization of periodic electromagnetic structures: Uncertainty principles

    NASA Astrophysics Data System (ADS)

    Tsukerman, Igor; Markel, Vadim A.

    2016-01-01

    We show that artificial magnetism of periodic dielectric or metal/dielectric structures has limitations and is subject to at least two "uncertainty principles." First, the stronger the magnetic response (the deviation of the effective permeability tensor from identity), the less accurate ("certain") the predictions of any homogeneous model. Second, if the magnetic response is strong, then homogenization cannot accurately reproduce the transmission and reflection parameters and, simultaneously, power dissipation in the material. These principles are general and not confined to any particular method of homogenization. Our theoretical analysis is supplemented with a numerical example: a hexahedral lattice of cylindrical air holes in a dielectric host. Even though this case is highly isotropic, which might be thought of as conducive to homogenization, the uncertainty principles remain valid.

  19. Welding deviation detection algorithm based on extremum of molten pool image contour

    NASA Astrophysics Data System (ADS)

    Zou, Yong; Jiang, Lipei; Li, Yunhua; Xue, Long; Huang, Junfen; Huang, Jiqiang

    2016-01-01

    The welding deviation detection is the basis of robotic tracking welding, but the on-line real-time measurement of welding deviation is still not well solved by the existing methods. There is plenty of information in the gas metal arc welding(GMAW) molten pool images that is very important for the control of welding seam tracking. The physical meaning for the curvature extremum of molten pool contour is revealed by researching the molten pool images, that is, the deviation information points of welding wire center and the molten tip center are the maxima and the local maxima of the contour curvature, and the horizontal welding deviation is the position difference of these two extremum points. A new method of weld deviation detection is presented, including the process of preprocessing molten pool images, extracting and segmenting the contours, obtaining the contour extremum points, and calculating the welding deviation, etc. Extracting the contours is the premise, segmenting the contour lines is the foundation, and obtaining the contour extremum points is the key. The contour images can be extracted with the method of discrete dyadic wavelet transform, which is divided into two sub contours including welding wire and molten tip separately. The curvature value of each point of the two sub contour lines is calculated based on the approximate curvature formula of multi-points for plane curve, and the two points of the curvature extremum are the characteristics needed for the welding deviation calculation. The results of the tests and analyses show that the maximum error of the obtained on-line welding deviation is 2 pixels(0.16 mm), and the algorithm is stable enough to meet the requirements of the pipeline in real-time control at a speed of less than 500 mm/min. The method can be applied to the on-line automatic welding deviation detection.

  20. Deviations of the glass transition temperature in amorphous conjugated polymer thin films

    NASA Astrophysics Data System (ADS)

    Liu, Dan; Osuna Orozco, Rodrigo; Wang, Tao

    2013-08-01

    The deviations of the glass transition temperature (Tg) in thin films of an amorphous conjugated polymer poly(9,9-dioctylfluorene-co-N-(4-butylphenyl)diphenylamine) (TFB) are reported. Monotonic and nonmonotonic Tg deviations are observed in TFB thin films supported on Si-SiOx and poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS), respectively. A three-layer model is developed to fit both monotonic and nonmonotonic Tg deviations in these films. A 5-nm PEDOT:PSS capping layer was not found to be effective to remove the free-surface effect in Si-SiOx supported TFB films.

  1. Deviations of the exciton level spectrum in Cu2O from the hydrogen series

    NASA Astrophysics Data System (ADS)

    Schöne, F.; Krüger, S.-O.; Grünwald, P.; Stolz, H.; Scheel, S.; Aßmann, M.; Heckötter, J.; Thewes, J.; Fröhlich, D.; Bayer, M.

    2016-02-01

    Recent high-resolution absorption spectroscopy on excited excitons in cuprous oxide [Nature (London) 514, 343 (2014), 10.1038/nature13832] has revealed significant deviations of their spectrum from that of the ideal hydrogen-like series. Here we show that the complex band dispersion of the crystal, which determines the kinetic energy of electrons and holes, strongly affects the exciton binding energy. Specifically, we show that the nonparabolicity of the band dispersion is the main cause of the deviation from the hydrogen series. Experimental data collected from high-resolution absorption spectroscopy in electric fields validate the assignment of the deviation to the nonparabolicity of the band dispersion.

  2. Toward Instructional Design Principles: Inducing Faraday's Law with Contrasting Cases

    ERIC Educational Resources Information Center

    Kuo, Eric; Wieman, Carl E.

    2016-01-01

    Although physics education research (PER) has improved instructional practices, there are not agreed upon principles for designing effective instructional materials. Here, we illustrate how close comparison of instructional materials could support the development of such principles. Specifically, in discussion sections of a large, introductory…

  3. Elucidation of DC Magnetic Deviation in Converter Transformers Used for a Self-Commutated BTB System during Single-Line-to-Ground Faults

    NASA Astrophysics Data System (ADS)

    Hagiwara, Makoto; Pham, Phuong Viet; Akagi, Hirofumi

    This paper deals with a 50-MW self-commutated BTB (Back-To-Back) system intended for power-flow control between transmission networks. It focuses on the dynamic behavior of the BTB system during single-line-to-ground (SLG) faults. During an SLG fault, a dc magnetic deviation appears in the converter-transformers used for the BTB system just after the occurrence and restoration of the fault. It is indispensable to understand an amount of deviation because it may bring magnetic saturation as well as a large amount of magnetizing current to the transformers. This paper derives theoretical equations related to the deviation during the SLG fault. The theoretical analysis developed in this paper would make significant contributions to designing the transformers.

  4. Principles of tendon transfers.

    PubMed

    Coulet, B

    2016-04-01

    Tendon transfers are carried out to restore functional deficits by rerouting the remaining intact muscles. Transfers are highly attractive in the context of hand surgery because of the possibility of restoring the patient's ability to grip. In palsy cases, tendon transfers are only used when a neurological procedure is contraindicated or has failed. The strategy used to restore function follows a common set of principles, no matter the nature of the deficit. The first step is to clearly distinguish between deficient muscles and muscles that could be transferred. Next, the type of palsy will dictate the scope of the program and the complexity of the gripping movements that can be restored. Based on this reasoning, a surgical strategy that matches the means (transferable muscles) with the objectives (functions to restore) will be established and clearly explained to the patient. Every paralyzed hand can be described using three parameters. 1) Deficient segments: wrist, thumb and long fingers; 2) mechanical performance of muscles groups being revived: high energy-wrist extension and finger flexion that require strong transfers with long excursion; low energy-wrist flexion and finger extension movements that are less demanding mechanically, because they can be accomplished through gravity alone in some cases; 3) condition of the two primary motors in the hand: extrinsics (flexors and extensors) and intrinsics (facilitator). No matter the type of palsy, the transfer surgery follows the same technical principles: exposure, release, fixation, tensioning and rehabilitation. By performing an in-depth analysis of each case and by following strict technical principles, tendon transfer surgery leads to reproducible results; this allows the surgeon to establish clear objectives for the patient preoperatively. PMID:27117119

  5. Protection - Principles and practice.

    NASA Technical Reports Server (NTRS)

    Graham, G. S.; Denning, P. J.

    1972-01-01

    The protection mechanisms of computer systems control the access to objects, especially information objects. The principles of protection system design are formalized as a model (theory) of protection. Each process has a unique identification number which is attached by the system to each access attempted by the process. Details of system implementation are discussed, taking into account the storing of the access matrix, aspects of efficiency, and the selection of subjects and objects. Two systems which have protection features incorporating all the elements of the model are described.

  6. The principle of reciprocity.

    PubMed

    Hoult, D I

    2011-12-01

    The circumstances surrounding the realisation that NMR signal reception could be quantified in a simple fundamental manner using Lorentz's Principle of Reciprocity are described. The poor signal-to-noise ratio of the first European superconducting magnet is identified as a major motivating factor, together with the author's need to understand phenomena at a basic level. A summary is then given of the thought processes leading to the very simple pseudo-static formula that has been the basis of signal-to-noise calculations for over a generation. PMID:21889377

  7. Talus fractures: surgical principles.

    PubMed

    Rush, Shannon M; Jennings, Meagan; Hamilton, Graham A

    2009-01-01

    Surgical treatment of talus fractures can challenge even the most skilled foot and ankle surgeon. Complicated fracture patterns combined with joint dislocation of variable degrees require accurate assessment, sound understanding of principles of fracture care, and broad command of internal fixation techniques needed for successful surgical care. Elimination of unnecessary soft tissue dissection, a low threshold for surgical reduction, liberal use of malleolar osteotomy to expose body fracture, and detailed attention to fracture reduction and joint alignment are critical to the success of treatment. Even with the best surgical care complications are common and seem to correlate with injury severity and open injuries. PMID:19121756

  8. Nonequilibrium quantum Landauer principle.

    PubMed

    Goold, John; Paternostro, Mauro; Modi, Kavan

    2015-02-13

    Using the operational framework of completely positive, trace preserving operations and thermodynamic fluctuation relations, we derive a lower bound for the heat exchange in a Landauer erasure process on a quantum system. Our bound comes from a nonphenomenological derivation of the Landauer principle which holds for generic nonequilibrium dynamics. Furthermore, the bound depends on the nonunitality of dynamics, giving it a physical significance that differs from other derivations. We apply our framework to the model of a spin-1/2 system coupled to an interacting spin chain at finite temperature. PMID:25723198

  9. Principles of smile design

    PubMed Central

    Bhuvaneswaran, Mohan

    2010-01-01

    An organized and systematic approach is required to evaluate, diagnose and resolve esthetic problems predictably. It is of prime importance that the final result is not dependent only on the looks alone. Our ultimate goal as clinicians is to achieve pleasing composition in the smile by creating an arrangement of various esthetic elements. This article reviews the various principles that govern the art of smile designing. The literature search was done using PubMed search and Medline. This article will provide a basic knowledge to the reader to bring out a functional stable smile. PMID:21217950

  10. Efficient Levenberg-Marquardt minimization of the maximum likelihood estimator for Poisson deviates

    SciTech Connect

    Laurence, T; Chromy, B

    2009-11-10

    Histograms of counted events are Poisson distributed, but are typically fitted without justification using nonlinear least squares fitting. The more appropriate maximum likelihood estimator (MLE) for Poisson distributed data is seldom used. We extend the use of the Levenberg-Marquardt algorithm commonly used for nonlinear least squares minimization for use with the MLE for Poisson distributed data. In so doing, we remove any excuse for not using this more appropriate MLE. We demonstrate the use of the algorithm and the superior performance of the MLE using simulations and experiments in the context of fluorescence lifetime imaging. Scientists commonly form histograms of counted events from their data, and extract parameters by fitting to a specified model. Assuming that the probability of occurrence for each bin is small, event counts in the histogram bins will be distributed according to the Poisson distribution. We develop here an efficient algorithm for fitting event counting histograms using the maximum likelihood estimator (MLE) for Poisson distributed data, rather than the non-linear least squares measure. This algorithm is a simple extension of the common Levenberg-Marquardt (L-M) algorithm, is simple to implement, quick and robust. Fitting using a least squares measure is most common, but it is the maximum likelihood estimator only for Gaussian-distributed data. Non-linear least squares methods may be applied to event counting histograms in cases where the number of events is very large, so that the Poisson distribution is well approximated by a Gaussian. However, it is not easy to satisfy this criterion in practice - which requires a large number of events. It has been well-known for years that least squares procedures lead to biased results when applied to Poisson-distributed data; a recent paper providing extensive characterization of these biases in exponential fitting is given. The more appropriate measure based on the maximum likelihood estimator (MLE

  11. Measurement based simulation of microscope deviations for evaluation of stitching algorithms for the extension of Fourier-based alignment

    NASA Astrophysics Data System (ADS)

    Engelke, Florian; Kästner, Markus; Reithmeier, Eduard

    2013-05-01

    Image stitching is a technique used to measure large surface areas with high resolution while maintaining a large field of view. We work on improving data fusion by stitching in the field of microscopic analysis of technical surfaces for structures and roughness. Guidance errors and imaging errors such as noise cause problems for seamless image fusion of technical surfaces. The optical imaging errors of 3D Microscopes, such as confocal microscopes and white light interferometers, as well as the guidance errors of their automated positioning systems have been measured to create a software to simulate automated measurements of known surfaces with specific deviations to test new stitching algorithms. We measured and incorporated radial image distortion, interferometer reference mirror shape deviations, statistical noise, drift of the positional axis, on-axis-accuracy and repeatability of the used positioning stages and misalignment of the CCD-Chip with respect to the axes of motion. We used the resulting simulation of the measurement process to test a new image registration technique that allows for the use of correlation of images by fast fourier transform for small overlaps between single measurements.

  12. Approaching sub-50 nanoradian measurements by reducing the saw-tooth deviation of the autocollimator in the Nano-Optic-Measuring Machine

    NASA Astrophysics Data System (ADS)

    Qian, Shinan; Geckeler, Ralf D.; Just, Andreas; Idir, Mourad; Wu, Xuehui

    2015-06-01

    Since the development of the Nano-Optic-Measuring Machine (NOM), the accuracy of measuring the profile of an optical surface has been enhanced to the 100-nrad rms level or better. However, to update the accuracy of the NOM system to sub-50 nrad rms, the large saw-tooth deviation (269 nrad rms) of an existing electronic autocollimator, the Elcomat 3000/8, must be resolved. We carried out simulations to assess the saw-tooth-like deviation. We developed a method for setting readings to reduce the deviation to sub-50 nrad rms, suitable for testing plane mirrors. With this method, we found that all the tests conducted in a slowly rising section of the saw-tooth show a small deviation of 28.8 to <40 nrad rms. We also developed a dense-measurement method and an integer-period method to lower the saw-tooth deviation during tests of sphere mirrors. Further research is necessary for formulating a precise test for a spherical mirror. We present a series of test results from our experiments that verify the value of the improvements we made.

  13. Academic Principles: A Brief Introduction

    ERIC Educational Resources Information Center

    Association of American Universities, 2013

    2013-01-01

    For many decades certain core principles have guided the conduct of teaching, research, and scholarship at American universities, as well as the ways in which these institutions are governed. There is ample evidence that these principles have strongly contributed to the quality of American universities. The principles have also made these…

  14. Archimedes' Principle in General Coordinates

    ERIC Educational Resources Information Center

    Ridgely, Charles T.

    2010-01-01

    Archimedes' principle is well known to state that a body submerged in a fluid is buoyed up by a force equal to the weight of the fluid displaced by the body. Herein, Archimedes' principle is derived from first principles by using conservation of the stress-energy-momentum tensor in general coordinates. The resulting expression for the force is…

  15. Principles of climate service development

    NASA Astrophysics Data System (ADS)

    Buontempo, Carlo; Liggins, Felicity; Newton, Paula

    2015-04-01

    In November 2014, a group of 30 international experts in climate service development gathered in Honiton, UK, to discuss and identify the key principles that should be considered when developing new climate services by all the actors involved. Through an interactive and dynamic workshop the attendees identified seven principles. This contribution summarises these principles.

  16. 40 CFR 60.2958 - What must I include in the deviation report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Qualification Recordkeeping and Reporting § 60.2958 What must I include in the deviation report? In each report... incidents (other than downtime associated with zero, span, and other routine calibration checks)....

  17. 40 CFR 60.2958 - What must I include in the deviation report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Qualification Recordkeeping and Reporting § 60.2958 What must I include in the deviation report? In each report... incidents (other than downtime associated with zero, span, and other routine calibration checks)....

  18. 41 CFR 102-33.10 - May we request approval to deviate from these rules?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...,” revised May 22, 1992. You should consult with GSA's Aircraft Management Policy Division (MTA) before you request a deviation. Also, you should fax a copy of your letter of request to MTA at 202-501-6742 at...

  19. Estimation of deviation angle for axial-flow compressor blade sections using inviscid-flow solutions

    NASA Technical Reports Server (NTRS)

    Miller, M. J.

    1974-01-01

    Development of a method of estimating deviation angles by analytical procedures was begun. Solutions for inviscid, irrotational flow in the blade-to-blade plane were obtained with a finite-difference calculation method. Deviation angles for a plane cascade with a rounded trailing edge were estimated by using the inviscid-flow solutions and three trailing-edge hypotheses. The estimated deviation angles were compared with existing experimental data over a range of incidence angles at inlet flow angles of 30 deg and 60 deg. The results indicate that deviation angles can be estimated accurately (within 1 deg) by using one of the three trailing-edge hypotheses, but only when pressure losses are low. A new trailing-edge hypotheses is presented which is suitable (for the cascade considered) for both low- and high-loss operating points.

  20. 49 CFR 192.943 - When can an operator deviate from these reassessment intervals?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Gas Transmission Pipeline Integrity Management § 192.943 When can an operator deviate from these...