Sample records for lat electron flux

  1. Searching for Dark Matter Signatures in the GLAST LAT Electron Flux

    NASA Technical Reports Server (NTRS)

    Moiseev, Alexander; Profumo, Stefano

    2008-01-01

    We explored several viable scenarios of how LAT might observe DM, when the spectral feature is predicted to be observed in the HE electron flux It has been demonstrated elsewhere that LAT will be capable to detect HE electrons flux in energy range from 20 GeV to - 1 TeV with 520% energy resolution and good statistics If there is a DM-caused feature in the HE electron flux (in the range 20 GeV - 1 TeV), LAT will be the best current instrument to observe it!

  2. Fermi LAT Observations of Cosmic-Ray Electrons

    NASA Technical Reports Server (NTRS)

    Moiseev, Alexander

    2011-01-01

    Designed as a gamma-ray instrument, the LAT is a capable detector of high energy cosmic ray electrons. The LAT is composed of a 4x4 array of identical towers. Each tower has a Tracker and a Calorimeter module. Entire LAT is covered by segmented Anti-Coincidence Detector (ACD). The electron data analysis is based on that developed for photons. The main challenge is to identify and separate electrons from all other charged species, mainly CR protons (for gamma-ray analysis this is provided by the Anti-Coincidence Detector)

  3. The Origins of the Gamma-Ray Flux Variations of NGC 1275 Based on Eight Years of Fermi-LAT Observations

    NASA Astrophysics Data System (ADS)

    Tanada, K.; Kataoka, J.; Arimoto, M.; Akita, M.; Cheung, C. C.; Digel, S. W.; Fukazawa, Y.

    2018-06-01

    We present an analysis of eight years of Fermi-LAT (>0.1 GeV) γ-ray data obtained for the radio galaxy NGC 1275. The γ-ray flux from NGC 1275 is highly variable on short (∼days to weeks) timescales, and has steadily increased over this eight year timespan. By examining the changes in its flux and spectral shape in the LAT energy band over the entire data set, we found that its spectral behavior changed around 2011 February (∼MJD 55600). The γ-ray spectra at early times evolved largely at high energies, while the photon indices were unchanged at later times despite rather large flux variations. To explain these observations, we suggest that the flux changes at the early times were caused by injection of high-energy electrons into the jet while, later, the γ-ray flares were caused by a changing Doppler factor owing to variations in the jet Lorentz factor and/or changes in the angle to our line of sight. To demonstrate the viability of these scenarios, we fit the broad band spectral energy distribution data with a one-zone synchrotron self-Compton (SSC) model for flaring and quiescent intervals before and after 2011 February. To explain the γ-ray spectral behavior in the context of the SSC model, the maximum electron Lorentz factor would have changed at the early times, while a modest change in the Doppler factor adequately fits the quiescent and flaring state γ-ray spectra at the later times.

  4. Theoretical Interpretation of Pass 8 Fermi -LAT e + + e - Data

    DOE PAGES

    Di Mauro, M.; Manconi, S.; Vittino, A.; ...

    2017-08-17

    The flux of positrons and electrons (e + + e -) has been measured by the Fermi Large Area Telescope (LAT) in the energy range between 7 GeV and 2 TeV. Here, we discuss a number of interpretations of Pass 8 Fermi-LAT e + + e - spectrum, combining electron and positron emission from supernova remnants (SNRs) and pulsar wind nebulae (PWNe), or produced by the collision of cosmic rays (CRs) with the interstellar medium. We also found that the Fermi-LAT spectrum is compatible with the sum of electrons from a smooth SNR population, positrons from cataloged PWNe, and amore » secondary component. If we include in our analysis constraints from the AMS-02 positron spectrum, we obtain a slightly worse fit to the e + + e - Fermi-LAT spectrum, depending on the propagation model. As an additional scenario, we replace the smooth SNR component within 0.7 kpc with the individual sources found in Green's catalog of Galactic SNRs. We find that separate consideration of far and near sources helps to reproduce the e + + e - Fermi-LAT spectrum. However, we show that the fit degrades when the radio constraints on the positron emission from Vela SNR (which is the main contributor at high energies) are taken into account. We find that a break in the power-law injection spectrum at about 100 GeV can also reproduce the measured e + + e -spectrum and, among the CR propagation models that we consider, no reasonable break of the power-law dependence of the diffusion coefficient can modify the electron flux enough to reproduce the observed shape.« less

  5. Theoretical Interpretation of Pass 8 Fermi -LAT e + + e - Data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Di Mauro, M.; Manconi, S.; Vittino, A.

    The flux of positrons and electrons (e + + e -) has been measured by the Fermi Large Area Telescope (LAT) in the energy range between 7 GeV and 2 TeV. Here, we discuss a number of interpretations of Pass 8 Fermi-LAT e + + e - spectrum, combining electron and positron emission from supernova remnants (SNRs) and pulsar wind nebulae (PWNe), or produced by the collision of cosmic rays (CRs) with the interstellar medium. We also found that the Fermi-LAT spectrum is compatible with the sum of electrons from a smooth SNR population, positrons from cataloged PWNe, and amore » secondary component. If we include in our analysis constraints from the AMS-02 positron spectrum, we obtain a slightly worse fit to the e + + e - Fermi-LAT spectrum, depending on the propagation model. As an additional scenario, we replace the smooth SNR component within 0.7 kpc with the individual sources found in Green's catalog of Galactic SNRs. We find that separate consideration of far and near sources helps to reproduce the e + + e - Fermi-LAT spectrum. However, we show that the fit degrades when the radio constraints on the positron emission from Vela SNR (which is the main contributor at high energies) are taken into account. We find that a break in the power-law injection spectrum at about 100 GeV can also reproduce the measured e + + e -spectrum and, among the CR propagation models that we consider, no reasonable break of the power-law dependence of the diffusion coefficient can modify the electron flux enough to reproduce the observed shape.« less

  6. Theoretical Interpretation of Pass 8 Fermi -LAT e {sup +} + e {sup −} Data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Di Mauro, M.; Manconi, S.; Donato, F.

    The flux of positrons and electrons ( e {sup +} + e {sup −}) has been measured by the Fermi Large Area Telescope (LAT) in the energy range between 7 GeV and 2 TeV. We discuss a number of interpretations of Pass 8 Fermi -LAT e {sup +} + e {sup −} spectrum, combining electron and positron emission from supernova remnants (SNRs) and pulsar wind nebulae (PWNe), or produced by the collision of cosmic rays (CRs) with the interstellar medium. We find that the Fermi -LAT spectrum is compatible with the sum of electrons from a smooth SNR population, positronsmore » from cataloged PWNe, and a secondary component. If we include in our analysis constraints from the AMS-02 positron spectrum, we obtain a slightly worse fit to the e {sup +} + e {sup −} Fermi -LAT spectrum, depending on the propagation model. As an additional scenario, we replace the smooth SNR component within 0.7 kpc with the individual sources found in Green’s catalog of Galactic SNRs. We find that separate consideration of far and near sources helps to reproduce the e {sup +} + e {sup −} Fermi -LAT spectrum. However, we show that the fit degrades when the radio constraints on the positron emission from Vela SNR (which is the main contributor at high energies) are taken into account. We find that a break in the power-law injection spectrum at about 100 GeV can also reproduce the measured e {sup +} + e {sup −} spectrum and, among the CR propagation models that we consider, no reasonable break of the power-law dependence of the diffusion coefficient can modify the electron flux enough to reproduce the observed shape.« less

  7. Constraints on dark matter models from a Fermi LAT search for high-energy cosmic-ray electrons from the Sun

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ajello, M.; Atwood, W. B.; Baldini, L.

    During its first year of data taking, the Large Area Telescope (LAT) onboard the Fermi Gamma-Ray Space Telescope has collected a large sample of high-energy cosmic-ray electrons and positrons (CREs). We present the results of a directional analysis of the CRE events, in which we searched for a flux excess correlated with the direction of the Sun. Two different and complementary analysis approaches were implemented, and neither yielded evidence of a significant CRE flux excess from the Sun. Here, we derive upper limits on the CRE flux from the Sun’s direction, and use these bounds to constrain two classes ofmore » dark matter models which predict a solar CRE flux: (1) models in which dark matter annihilates to CREs via a light intermediate state, and (2) inelastic dark matter models in which dark matter annihilates to CREs.« less

  8. Constraints on dark matter models from a Fermi LAT search for high-energy cosmic-ray electrons from the Sun

    DOE PAGES

    Ajello, M.; Atwood, W. B.; Baldini, L.; ...

    2011-08-15

    During its first year of data taking, the Large Area Telescope (LAT) onboard the Fermi Gamma-Ray Space Telescope has collected a large sample of high-energy cosmic-ray electrons and positrons (CREs). We present the results of a directional analysis of the CRE events, in which we searched for a flux excess correlated with the direction of the Sun. Two different and complementary analysis approaches were implemented, and neither yielded evidence of a significant CRE flux excess from the Sun. Here, we derive upper limits on the CRE flux from the Sun’s direction, and use these bounds to constrain two classes ofmore » dark matter models which predict a solar CRE flux: (1) models in which dark matter annihilates to CREs via a light intermediate state, and (2) inelastic dark matter models in which dark matter annihilates to CREs.« less

  9. Chandra and Swift Observations of Unidentified Fermi-LAT Objects

    NASA Astrophysics Data System (ADS)

    Donato, Davide; Cheung, T.; Gehrels, N.

    2010-03-01

    In the last year we targeted some of the unidentified Fermi-LAT objects (UFOs) at high Galactic latitude with Chandra and Swift in order to determine the basic properties (positions, fluxes, hardness ratios) of all X-ray sources within the Fermi-LAT localization circles. These satellites enable us to detect the X-ray conterparts with a flux limit that is at least an order of magnitude lower than achieved in extant RASS data and to further follow-up at other wavelengths, with the ultimate goal to reveal the nature of these enigmatic gamma-ray sources. Here we present the results obtained with 5 Chandra pointings of high Galactic latitude UFOs in the Fermi-LAT 3-months bright source list. The association of detected X-ray sources within the improved 11-months Fermi-LAT localization circles with available optical and radio observations is discussed.

  10. Fermi-LAT upper limits on gamma-ray emission from colliding wind binaries

    DOE PAGES

    Werner, Michael; Reimer, O.; Reimer, A.; ...

    2013-07-09

    Here, colliding wind binaries (CWBs) are thought to give rise to a plethora of physical processes including acceleration and interaction of relativistic particles. Observation of synchrotron radiation in the radio band confirms there is a relativistic electron population in CWBs. Accordingly, CWBs have been suspected sources of high-energy γ-ray emission since the COS-B era. Theoretical models exist that characterize the underlying physical processes leading to particle acceleration and quantitatively predict the non-thermal energy emission observable at Earth. Furthermore, we strive to find evidence of γ-ray emission from a sample of seven CWB systems: WR 11, WR 70, WR 125, WRmore » 137, WR 140, WR 146, and WR 147. Theoretical modelling identified these systems as the most favourable candidates for emitting γ-rays. We make a comparison with existing γ-ray flux predictions and investigate possible constraints. We used 24 months of data from the Large Area Telescope (LAT) on-board the Fermi Gamma Ray Space Telescope to perform a dedicated likelihood analysis of CWBs in the LAT energy range. As a result, we find no evidence of γ-ray emission from any of the studied CWB systems and determine corresponding flux upper limits. For some CWBs the interplay of orbital and stellar parameters renders the Fermi-LAT data not sensitive enough to constrain the parameter space of the emission models. In the cases of WR140 and WR147, the Fermi -LAT upper limits appear to rule out some model predictions entirely and constrain theoretical models over a significant parameter space. A comparison of our findings to the CWB η Car is made.« less

  11. Identifying Unidentified Fermi-LAT Objects (UFOs) at High-Latitude

    NASA Astrophysics Data System (ADS)

    Cheung, Chi Teddy

    2009-09-01

    We propose a Chandra study of 8 high Galactic latitude gamma-ray sources in the Fermi-LAT bright source list. These sources are currently unidentified, i.e., they are not clearly associated with established classes of gamma-ray emitters like blazars and pulsars. The proposed observations will determine the basic properties (fluxes, positions, hardness ratio/spectra) of all X-ray sources down to a 0.3-10 keV flux limit of 1.5e-14 erg/cm2/s within the Fermi-LAT localization circles. This will enable further follow-up at other wavelengths, with the ultimate goal to reveal the nature of these enigmatic gamma-ray sources.

  12. Fermi-LAT and Suzaku observations of the radio galaxy Centaurus B

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Katsuta, J.; Tanaka, Y. T.; Stawarz, Ł.

    2013-01-28

    Centaurus B is a nearby radio galaxy positioned in the southern hemisphere close to the Galactic plane. Here, in this work, we present a detailed analysis of about 43 months of accumulated Fermi-LAT data of the γ-ray counterpart of the source initially reported in the 2nd Fermi-LAT catalog, and of newly acquired Suzaku X-ray data. We confirm its detection at GeV photon energies and analyze the extension and variability of the γ-ray source in the LAT dataset, in which it appears as a steady γ-ray emitter. The X-ray core of Centaurus B is detected as a bright source of amore » continuum radiation. We do not detect, however, any diffuse X-ray emission from the known radio lobes, with the provided upper limit only marginally consistent with the previously claimed ASCA flux. Two scenarios that connect the X-ray and γ-ray properties are considered. In the first one, we assume that the diffuse non-thermal X-ray emission component is not significantly below the derived Suzaku upper limit. In this case, modeling the inverse-Compton emission shows that the observed γ-ray flux of the source may in principle be produced within the lobes. This association would imply that efficient in-situ acceleration of the radiating electrons is occurring and that the lobes are dominated by the pressure from the relativistic particles. In the second scenario, with the diffuse X-ray emission well below the Suzaku upper limits, the lobes in the system are instead dominated by the magnetic pressure. In this case, the observed γ-ray flux is not likely to be produced within the lobes, but instead within the nuclear parts of the jet. In conclusion, by means of synchrotron self-Compton modeling, we show that this possibility could be consistent with the broad-band data collected for the unresolved core of Centaurus B, including the newly derived Suzaku spectrum.« less

  13. Fermi LAT Stacking Analysis of Swift Localized GRBs

    DOE PAGES

    Ackermann, M.; Ajello, M.; Anderson, B.; ...

    2016-05-05

    In this paper, we perform a comprehensive stacking analysis of data collected by the Fermi Large Area Telescope (LAT) of γ-ray bursts (GRBs) localized by the Swift spacecraft, which were not detected by the LAT but which fell within the instrument's field of view at the time of trigger. We examine a total of 79 GRBs by comparing the observed counts over a range of time intervals to that expected from designated background orbits, as well as by using a joint likelihood technique to model the expected distribution of stacked counts. We find strong evidence for subthreshold emission at MeVmore » to GeV energies using both techniques. This observed excess is detected during intervals that include and exceed the durations typically characterizing the prompt emission observed at keV energies and lasts at least 2700 s after the co-aligned burst trigger. By utilizing a novel cumulative likelihood analysis, we find that although a burst's prompt γ-ray and afterglow X-ray flux both correlate with the strength of the subthreshold emission, the X-ray afterglow flux measured by Swift's X-ray Telescope at 11 hr post trigger correlates far more significantly. Overall, the extended nature of the subthreshold emission and its connection to the burst's afterglow brightness lend further support to the external forward shock origin of the late-time emission detected by the LAT. Finally, these results suggest that the extended high-energy emission observed by the LAT may be a relatively common feature but remains undetected in a majority of bursts owing to instrumental threshold effects.« less

  14. 3FHL: The Third Catalog of Hard Fermi -LAT Sources

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ajello, M.; Atwood, W. B.; Baldini, L.

    Here, we present a catalog of sources detected above 10 GeV by the Fermi Large Area Telescope (LAT) in the first 7 years of data using the Pass 8 event-level analysis. This is the Third Catalog of Hard Fermi-LAT Sources (3FHL), containing 1556 objects characterized in the 10 GeV–2 TeV energy range. The sensitivity and angular resolution are improved by factors of 3 and 2 relative to the previous LAT catalog at the same energies (1FHL). The vast majority of detected sources (79%) are associated with extragalactic counterparts at other wavelengths, including 16 sources located at very high redshift (zmore » > 2). Of the sources, 8% have Galactic counterparts and 13% are unassociated (or associated with a source of unknown nature). The high-latitude sky and the Galactic plane are observed with a flux sensitivity of 4.4 to 9.5 × 10 -11 ph cm -2 s -1, respectively (this is approximately 0.5% and 1% of the Crab Nebula flux above 10 GeV). The catalog includes 214 new γ-ray sources. The substantial increase in the number of photons (more than 4 times relative to 1FHL and 10 times to 2FHL) also allows us to measure significant spectral curvature for 32 sources and find flux variability for 163 of them. We also estimate that for the same flux limit of 10 -12 erg cm -2 s -1, the energy range above 10 GeV has twice as many sources as the range above 50 GeV, highlighting the importance, for future Cherenkov telescopes, of lowering the energy threshold as much as possible.« less

  15. 3FHL: The Third Catalog of Hard Fermi -LAT Sources

    DOE PAGES

    Ajello, M.; Atwood, W. B.; Baldini, L.; ...

    2017-09-27

    Here, we present a catalog of sources detected above 10 GeV by the Fermi Large Area Telescope (LAT) in the first 7 years of data using the Pass 8 event-level analysis. This is the Third Catalog of Hard Fermi-LAT Sources (3FHL), containing 1556 objects characterized in the 10 GeV–2 TeV energy range. The sensitivity and angular resolution are improved by factors of 3 and 2 relative to the previous LAT catalog at the same energies (1FHL). The vast majority of detected sources (79%) are associated with extragalactic counterparts at other wavelengths, including 16 sources located at very high redshift (zmore » > 2). Of the sources, 8% have Galactic counterparts and 13% are unassociated (or associated with a source of unknown nature). The high-latitude sky and the Galactic plane are observed with a flux sensitivity of 4.4 to 9.5 × 10 -11 ph cm -2 s -1, respectively (this is approximately 0.5% and 1% of the Crab Nebula flux above 10 GeV). The catalog includes 214 new γ-ray sources. The substantial increase in the number of photons (more than 4 times relative to 1FHL and 10 times to 2FHL) also allows us to measure significant spectral curvature for 32 sources and find flux variability for 163 of them. We also estimate that for the same flux limit of 10 -12 erg cm -2 s -1, the energy range above 10 GeV has twice as many sources as the range above 50 GeV, highlighting the importance, for future Cherenkov telescopes, of lowering the energy threshold as much as possible.« less

  16. 3FHL: The Third Catalog of Hard Fermi-LAT Sources

    NASA Astrophysics Data System (ADS)

    Ajello, M.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bellazzini, R.; Bissaldi, E.; Blandford, R. D.; Bloom, E. D.; Bonino, R.; Bregeon, J.; Britto, R. J.; Bruel, P.; Buehler, R.; Buson, S.; Cameron, R. A.; Caputo, R.; Caragiulo, M.; Caraveo, P. A.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Chekhtman, A.; Cheung, C. C.; Chiaro, G.; Ciprini, S.; Cohen, J. M.; Costantin, D.; Costanza, F.; Cuoco, A.; Cutini, S.; D'Ammando, F.; de Palma, F.; Desiante, R.; Digel, S. W.; Di Lalla, N.; Di Mauro, M.; Di Venere, L.; Domínguez, A.; Drell, P. S.; Dumora, D.; Favuzzi, C.; Fegan, S. J.; Ferrara, E. C.; Fortin, P.; Franckowiak, A.; Fukazawa, Y.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Giglietto, N.; Giommi, P.; Giordano, F.; Giroletti, M.; Glanzman, T.; Green, D.; Grenier, I. A.; Grondin, M.-H.; Grove, J. E.; Guillemot, L.; Guiriec, S.; Harding, A. K.; Hays, E.; Hewitt, J. W.; Horan, D.; Jóhannesson, G.; Kensei, S.; Kuss, M.; La Mura, G.; Larsson, S.; Latronico, L.; Lemoine-Goumard, M.; Li, J.; Longo, F.; Loparco, F.; Lott, B.; Lubrano, P.; Magill, J. D.; Maldera, S.; Manfreda, A.; Mazziotta, M. N.; McEnery, J. E.; Meyer, M.; Michelson, P. F.; Mirabal, N.; Mitthumsiri, W.; Mizuno, T.; Moiseev, A. A.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Negro, M.; Nuss, E.; Ohsugi, T.; Omodei, N.; Orienti, M.; Orlando, E.; Palatiello, M.; Paliya, V. S.; Paneque, D.; Perkins, J. S.; Persic, M.; Pesce-Rollins, M.; Piron, F.; Porter, T. A.; Principe, G.; Rainò, S.; Rando, R.; Razzano, M.; Razzaque, S.; Reimer, A.; Reimer, O.; Reposeur, T.; Saz Parkinson, P. M.; Sgrò, C.; Simone, D.; Siskind, E. J.; Spada, F.; Spandre, G.; Spinelli, P.; Stawarz, L.; Suson, D. J.; Takahashi, M.; Tak, D.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Torres, D. F.; Torresi, E.; Troja, E.; Vianello, G.; Wood, K.; Wood, M.

    2017-10-01

    We present a catalog of sources detected above 10 GeV by the Fermi Large Area Telescope (LAT) in the first 7 years of data using the Pass 8 event-level analysis. This is the Third Catalog of Hard Fermi-LAT Sources (3FHL), containing 1556 objects characterized in the 10 GeV-2 TeV energy range. The sensitivity and angular resolution are improved by factors of 3 and 2 relative to the previous LAT catalog at the same energies (1FHL). The vast majority of detected sources (79%) are associated with extragalactic counterparts at other wavelengths, including 16 sources located at very high redshift (z > 2). Of the sources, 8% have Galactic counterparts and 13% are unassociated (or associated with a source of unknown nature). The high-latitude sky and the Galactic plane are observed with a flux sensitivity of 4.4 to 9.5 × 10-11 ph cm-2 s-1, respectively (this is approximately 0.5% and 1% of the Crab Nebula flux above 10 GeV). The catalog includes 214 new γ-ray sources. The substantial increase in the number of photons (more than 4 times relative to 1FHL and 10 times to 2FHL) also allows us to measure significant spectral curvature for 32 sources and find flux variability for 163 of them. Furthermore, we estimate that for the same flux limit of 10-12 erg cm-2 s-1, the energy range above 10 GeV has twice as many sources as the range above 50 GeV, highlighting the importance, for future Cherenkov telescopes, of lowering the energy threshold as much as possible.

  17. 3FHL: The Third Catalog of Hard Fermi -LAT Sources

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ajello, M.; Atwood, W. B.; Baldini, L.

    We present a catalog of sources detected above 10 GeV by the Fermi Large Area Telescope (LAT) in the first 7 years of data using the Pass 8 event-level analysis. This is the Third Catalog of Hard Fermi -LAT Sources (3FHL), containing 1556 objects characterized in the 10 GeV–2 TeV energy range. The sensitivity and angular resolution are improved by factors of 3 and 2 relative to the previous LAT catalog at the same energies (1FHL). The vast majority of detected sources (79%) are associated with extragalactic counterparts at other wavelengths, including 16 sources located at very high redshift (more » z > 2). Of the sources, 8% have Galactic counterparts and 13% are unassociated (or associated with a source of unknown nature). The high-latitude sky and the Galactic plane are observed with a flux sensitivity of 4.4 to 9.5 × 10{sup −11} ph cm{sup −2} s{sup −1}, respectively (this is approximately 0.5% and 1% of the Crab Nebula flux above 10 GeV). The catalog includes 214 new γ -ray sources. The substantial increase in the number of photons (more than 4 times relative to 1FHL and 10 times to 2FHL) also allows us to measure significant spectral curvature for 32 sources and find flux variability for 163 of them. Furthermore, we estimate that for the same flux limit of 10{sup −12} erg cm{sup −2} s{sup −1}, the energy range above 10 GeV has twice as many sources as the range above 50 GeV, highlighting the importance, for future Cherenkov telescopes, of lowering the energy threshold as much as possible.« less

  18. New Results on High Energy Cosmic Ray Electrons Observed with Fermi LAT and Their Implications on the Models of Pulsars

    NASA Technical Reports Server (NTRS)

    Moiseev, Alexander

    2010-01-01

    This viewgraph presentation describes, in detail, the Fermi Large Area Telescope (LAT) and GLAST Burst Monitor (GBM). Observations made from the June 11, 2008 launch and a discussion of observations made of high energy cosmic ray electrons is also presented.

  19. Local H i emissivity measured with FERMI-LAT and implications for Cosmic-ray spectra

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Casandjian, Jean -Marc

    Cosmic-ray (CR) electrons and nuclei interact with the Galactic interstellar gas and produce high-energy γ-rays. The γ-ray emission rate per hydrogen atom, called emissivity, provides a unique indirect probe of the CR flux. We present the measurement and the interpretation of the emissivity in the solar neighborhood for γ-ray energy from 50 MeV to 50 GeV. We analyzed a subset of 4 yr of observations from the Large Area Telescope (LAT) aboard the Fermi Gamma-ray Space Telescope ( Fermi) restricted to absolute latitudesmore » $$10^\\circ \\lt | b| \\lt 70^\\circ $$. From a fit to the LAT data including atomic, molecular, and ionized hydrogen column density templates, as well as a dust optical depth map, we derived the emissivities, the molecular hydrogen–to–CO conversion factor $${X}_{\\mathrm{CO}}=(0.902\\pm 0.007)\\times {10}^{20}$$ cm–2 (K km s–1)–1, and the dust-to-gas ratio $${X}_{\\mathrm{DUST}}=(41.4\\pm 0.3)\\times {10}^{20}$$ cm–2 mag–1. Moreover, we detected for the first time γ-ray emission from ionized hydrogen. We compared the extracted emissivities to those calculated from γ-ray production cross sections and to CR spectra measured in the heliosphere. We observed that the experimental emissivities are reproduced only if the solar modulation is accounted for. This provides a direct detection of solar modulation observed previously through the anticorrelation between CR fluxes and solar activity. Lastly, we fitted a parameterized spectral form to the heliospheric CR observations and to the Fermi-LAT emissivity and obtained compatible local interstellar spectra for proton and helium kinetic energy per nucleon between between 1 and 100 GeV and for electron–positrons between 0.1 and 100 GeV.« less

  20. Local H i emissivity measured with FERMI-LAT and implications for Cosmic-ray spectra

    DOE PAGES

    Casandjian, Jean -Marc

    2015-06-20

    Cosmic-ray (CR) electrons and nuclei interact with the Galactic interstellar gas and produce high-energy γ-rays. The γ-ray emission rate per hydrogen atom, called emissivity, provides a unique indirect probe of the CR flux. We present the measurement and the interpretation of the emissivity in the solar neighborhood for γ-ray energy from 50 MeV to 50 GeV. We analyzed a subset of 4 yr of observations from the Large Area Telescope (LAT) aboard the Fermi Gamma-ray Space Telescope ( Fermi) restricted to absolute latitudesmore » $$10^\\circ \\lt | b| \\lt 70^\\circ $$. From a fit to the LAT data including atomic, molecular, and ionized hydrogen column density templates, as well as a dust optical depth map, we derived the emissivities, the molecular hydrogen–to–CO conversion factor $${X}_{\\mathrm{CO}}=(0.902\\pm 0.007)\\times {10}^{20}$$ cm–2 (K km s–1)–1, and the dust-to-gas ratio $${X}_{\\mathrm{DUST}}=(41.4\\pm 0.3)\\times {10}^{20}$$ cm–2 mag–1. Moreover, we detected for the first time γ-ray emission from ionized hydrogen. We compared the extracted emissivities to those calculated from γ-ray production cross sections and to CR spectra measured in the heliosphere. We observed that the experimental emissivities are reproduced only if the solar modulation is accounted for. This provides a direct detection of solar modulation observed previously through the anticorrelation between CR fluxes and solar activity. Lastly, we fitted a parameterized spectral form to the heliospheric CR observations and to the Fermi-LAT emissivity and obtained compatible local interstellar spectra for proton and helium kinetic energy per nucleon between between 1 and 100 GeV and for electron–positrons between 0.1 and 100 GeV.« less

  1. Communication: On the calculation of time-dependent electron flux within the Born-Oppenheimer approximation: A flux-flux reflection principle

    NASA Astrophysics Data System (ADS)

    Albert, Julian; Hader, Kilian; Engel, Volker

    2017-12-01

    It is commonly assumed that the time-dependent electron flux calculated within the Born-Oppenheimer (BO) approximation vanishes. This is not necessarily true if the flux is directly determined from the continuity equation obeyed by the electron density. This finding is illustrated for a one-dimensional model of coupled electronic-nuclear dynamics. There, the BO flux is in perfect agreement with the one calculated from a solution of the time-dependent Schrödinger equation for the coupled motion. A reflection principle is derived where the nuclear BO flux is mapped onto the electronic flux.

  2. Constraints on cosmological dark matter annihilation from the Fermi-LAT isotropic diffuse gamma-ray measurement

    DOE PAGES

    Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

    2010-04-01

    The first published Fermi large area telescope (Fermi-LAT) measurement of the isotropic diffuse gamma-ray emission is in good agreement with a single power law, and is not showing any signature of a dominant contribution from dark matter sources in the energy range from 20 to 100 GeV. Here, we use the absolute size and spectral shape of this measured flux to derive cross section limits on three types of generic dark matter candidates: annihilating into quarks, charged leptons and monochromatic photons. Predicted gamma-ray fluxes from annihilating dark matter are strongly affected by the underlying distribution of dark matter, and bymore » using different available results of matter structure formation we assess these uncertainties. We also quantify how the dark matter constraints depend on the assumed conventional backgrounds and on the Universe's transparency to high-energy gamma-rays. In reasonable background and dark matter structure scenarios (but not in all scenarios we consider) it is possible to exclude models proposed to explain the excess of electrons and positrons measured by the Fermi-LAT and PAMELA experiments. Derived limits also start to probe cross sections expected from thermally produced relics (e.g. in minimal supersymmetry models) annihilating predominantly into quarks. Finally, for the monochromatic gamma-ray signature, the current measurement constrains only dark matter scenarios with very strong signals.« less

  3. Atmospheric electron flux at airplane altitude

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Enomoto, R.; Chiba, J.; Ogawa, K.

    1991-12-01

    We have developed a new detector to systematically measure the cosmic-ray electron flux at airplane altitudes. We loaded a lead-glass-based electron telescope onto a commercial cargo airplane. The first experiment was carried out using the air route between Narita (Japan) and Sydney (Australia); during this flight we measured the electron flux at various altitudes and latitudes. The thresholds of the electron energies were 1, 2, and 4 GeV. The results agree with a simple estimation using one-dimensional shower theory. A comparison with a Monte Carlo calculation was made.

  4. Fermi LAT detection of enhanced gamma-ray emission from the Crab Nebula region

    NASA Astrophysics Data System (ADS)

    Ojha, Roopesh; Buehler, Rolf; Hays, Elizabeth; Dutka, Michael

    2012-07-01

    The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed a significant increase in the gamma-ray activity from a source positionally consistent with the Crab Nebula on July 3, 2012. Preliminary LAT analysis indicates that the daily-averaged gamma-ray emission (E >100 MeV) from the direction of the Crab doubled from (2.4 +/- 0.5) x 10^-6 ph/cm2/sec (statistical errors only) on July 2nd to (5.5 +/- 0.7) x 10^-6 ph/cm2/sec on July 3rd, a factor of 2 greater than the average flux of (2.75 +/- 0.10) x 10^-6 ph/cm2/sec reported in the second Fermi LAT catalog (2FGL, Nolan et al.

  5. Fermi LAT Results and Perspectives in Measurements of High Energy Galactic Cosmic Rays

    NASA Technical Reports Server (NTRS)

    Moiseev, Alexander

    2010-01-01

    Real breakthrough during last 1-1.5 years in cosmic ray electrons: ATIC, HESS, Pamela, and finally Fermi-LAT. New quality data have made it possible to start quantitative modeling. With the new data more puzzles than before on CR electrons origin. Need "multi-messenger" campaign: electrons, positrons, gammas, X-ray, radio, neutrino... It is viable that we are dealing with at least two distinct mechanisms of "primary" electron (both signs) production: a softer spectrum of negative electrons, and a harder spectrum of both e(+)+e(-). Exotic (e.g. DM) origin is not ruled out. Upper limits on CR electrons anisotropy are set. Good perspectives to have the Fermi LAT results on proton spectrum and positron fraction.

  6. Observational constraints on relativistic electron dynamics: temporal evolution of electron spectra and flux isotropization

    NASA Astrophysics Data System (ADS)

    Kanekal, S. G.; Selesnick, R. S.; Baker, D. N.; Blake, J. B.

    2007-05-01

    Models of energization of electrons in the Earth's outer radiation belts invoke two classes of processes, radial transport and in-situ wave-particle interactions. Temporal evolution of electron spectra and flux isotropization during energization events provide useful observational constraints on models of electron energization. Events dominated by radial diffusion result in pancake type pitch angle distributions whereas some in-situ wave-particle energization mechanisms include pitch angle scattering leading to rapid flux isotropization. We present a survey of flux isotrpization time scales and electron spectra during relativstic electron enhancement events. We will use data collected by detectors onboard SAMPEX in low earth orbit and Polar which measures electron fluxes at higher altitude to measure flux isotropization. Electron spectra are obtained by pulse height analyzed data from the PET detector onboard SAMPEX.SAMPEX measurements cover the entire outer zone for more than a decade from mid 1992 to mid 2004 and Polar covers the time period from mid 1996 to the present.

  7. Fermi LAT Observations of the Crab Nebula During the Exceptional April 2011 Outburst

    NASA Technical Reports Server (NTRS)

    Hays, Elizabeth

    2012-01-01

    The Crab Nebula, formerly thought to be steady in gamma rays, shows unexpected and occasionally dramatic variability in high-energy gamma rays. The Large Area Telescope (LAT) on Fermi recorded several strong outbursts, including dedicated pointed observations of the brightest yet seen, a spectacular flare in April 2011. These observations provide a particularly detailed look at the temporal and spectral characteristics of the nebula during the flare. The LAT data show an additional component in the spectral energy distribution that peaks at a maximum of $375\\pm26\\mathrm{MeV}$. In the probable scenario that this component is synchrotron emission, the electrons are accelerated to extreme energies that are difficult to reconcile with the very rapid change in flux and the expectation for acceleration processes and conditions occurring within the pulsar wind nebula. The physical location and mechanism driving the flares remains undetermined despite observations across the spectrum made by a variety of instruments including the Hubble Space Telescope, the Chandra X-ray Observatory, and the Very Large Array. I will present timing and spectral studies of the high-energy gamma-ray data, discuss implications for the origin of the flares, and highlight preparations for the next major flare.

  8. Fermi-LAT Detection of Gravitational Lens Delayed Gamma-Ray Flares from Blazar B0218+357

    NASA Technical Reports Server (NTRS)

    Cheung, C. C.; Larsson, S.; Scargle, J. D.; Amin, M. A.; Blandford, R. D.; Bulmash, D.; Chiang, J.; Ciprini, S.; Corbet, R. D. H.; Falco, E. E.; hide

    2014-01-01

    Using data from the Fermi Large Area Telescope (LAT), we report the first clear gamma-ray measurement of a delay between flares from the gravitationally lensed images of a blazar. The delay was detected in B0218+357, a known double-image lensed system, during a period of enhanced gamma-ray activity with peak fluxes consistently observed to reach greater than 20-50 times its previous average flux. An auto-correlation function analysis identified a delay in the gamma-ray data of 11.46 plus or minus 0.16 days (1 sigma) that is approximately 1 day greater than previous radio measurements. Considering that it is beyond the capabilities of the LAT to spatially resolve the two images, we nevertheless decomposed individual sequences of superposing gamma-ray flares/delayed emissions. In three such approximately 8-10 day-long sequences within an approximately 4-month span, considering confusion due to overlapping flaring emission and flux measurement uncertainties, we found flux ratios consistent with approximately 1, thus systematically smaller than those from radio observations. During the first, best-defined flare, the delayed emission was detailed with a Fermi pointing, and we observed flux doubling timescales of approximately 3-6 hours implying as well extremely compact gamma-ray emitting regions.

  9. Fermi-LAT Search for Pulsar Wind Nebulae around gamma-ray Pulsars

    DOE PAGES

    Ackermann, M.; Ajello, M.; Baldini, L.; ...

    2010-12-13

    The high sensitivity of the Fermi-LAT (Large Area Telescope) offers the first opportunity to study faint and extended GeV sources such as pulsar wind nebulae (PWNe). After one year of observation the LAT detected and identified three PWNe: the Crab Nebula, Vela-X, and the PWN inside MSH 15-52. In the meantime, the list of LAT detected pulsars increased steadily. These pulsars are characterized by high energy loss rates (more » $$\\dot{E}$$) from ~3 × 10 33 erg s –1 to 5 × 10 38 erg s –1 and are therefore likely to power a PWN. This paper summarizes the search for PWNe in the off-pulse windows of 54 LAT-detected pulsars using 16 months of survey observations. Ten sources show significant emission, seven of these likely being of magnetospheric origin. The detection of significant emission in the off-pulse interval offers new constraints on the γ-ray emitting regions in pulsar magnetospheres. The three other sources with significant emission are the Crab Nebula, Vela-X, and a new PWN candidate associated with the LAT pulsar PSR J1023–5746, coincident with the TeV source HESS J1023–575. Here, we further explore the association between the HESS and the Fermi source by modeling its spectral energy distribution. Lastly, flux upper limits derived for the 44 remaining sources are used to provide new constraints on famous PWNe that have been detected at keV and/or TeV energies.« less

  10. Fermi/LAT Observations of Swift/BAT Seyfert Galaxies: On the Contribution of Radio-Quiet Active Galactic Nuclei to the Extragalactic gamma-Ray Background

    NASA Technical Reports Server (NTRS)

    Teng, Stacy H.; Mushotzky, Richard F.; Sambruna, Rita M.; Davis, David S.; Reynolds, Christopher S.

    2011-01-01

    We present the analysis of 2.1 years of Fermi Large Area Telescope (LAT) data on 491 Seyfert galaxies detected by the Swift Burst Alert Telescope (BAT) survey. Only the two nearest objects, NGC 1068 and NGC 4945, which were identified in the Fermi first year catalog, are detected. Using Swift/BAT and radio 20 cm fluxes, we define a new radio-loudness parameter R(sub X,BAT) where radio-loud objects have logR(sub X,BAT) > -4.7. Based on this parameter, only radio-loud sources are detected by Fermi/LAT. An upper limit to the flux of the undetected sources is derived to be approx.2x10(exp -11) photons/sq cm/s, approximately seven times lower than the observed flux of NGC 1068. Assuming a median redshift of 0.031, this implies an upper limit to the gamma-ray (1-100 GeV) luminosity of < approx.3x10(exp 41) erg/s. In addition, we identified 120 new Fermi/LAT sources near the Swift/BAT Seyfert galaxies with significant Fermi/LAT detections. A majority of these objects do not have Swift/BAT counterparts, but their possible optical counterparts include blazars, flat-spectrum radio quasars, and quasars.

  11. FERMI/LAT OBSERVATIONS OF SWIFT/BAT SEYFERT GALAXIES: ON THE CONTRIBUTION OF RADIO-QUIET ACTIVE GALACTIC NUCLEI TO THE EXTRAGALACTIC {gamma}-RAY BACKGROUND

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Teng, Stacy H.; Mushotzky, Richard F.; Reynolds, Christopher S.

    2011-12-01

    We present the analysis of 2.1 years of Fermi Large Area Telescope (LAT) data on 491 Seyfert galaxies detected by the Swift Burst Alert Telescope (BAT) survey. Only the two nearest objects, NGC 1068 and NGC 4945, which were identified in the Fermi first year catalog, are detected. Using Swift/BAT and radio 20 cm fluxes, we define a new radio-loudness parameter R{sub X,BAT} where radio-loud objects have log R{sub X,BAT} > -4.7. Based on this parameter, only radio-loud sources are detected by Fermi/LAT. An upper limit to the flux of the undetected sources is derived to be {approx}2 Multiplication-Sign 10{supmore » -11} photons cm{sup -2} s{sup -1}, approximately seven times lower than the observed flux of NGC 1068. Assuming a median redshift of 0.031, this implies an upper limit to the {gamma}-ray (1-100 GeV) luminosity of {approx}< 3 Multiplication-Sign 10{sup 41} erg s{sup -1}. In addition, we identified 120 new Fermi/LAT sources near the Swift/BAT Seyfert galaxies with significant Fermi/LAT detections. A majority of these objects do not have Swift/BAT counterparts, but their possible optical counterparts include blazars, flat-spectrum radio quasars, and quasars.« less

  12. Search for Gamma-Ray Emission from Galactic Novae using Fermi-LAT Pass 8

    NASA Astrophysics Data System (ADS)

    Buson, Sara; Franckowiak, Anna; Cheung, Teddy; Jean, Pierre; Fermi-LAT Collaboration

    2016-01-01

    Recently Galactic novae have been identified as a new class of GeV gamma-ray emitters, with 6 detected so far with the Fermi Large Area Telescope (Fermi-LAT) data. Based on optical observations we have compiled a catalog of ~70 Galactic novae, which peak (in optical) during the operations of the Fermi mission. Based on the properties of known gamma-ray novae we developed a search procedure that we apply to all novae in the catalog to detect these slow transient sources or set flux upper limits using the Fermi-LAT Pass 8 data set. This is the first time a large sample of Galactic novae has been uniformly studied.

  13. Gamma-Ray Flaring Activity from the Gravitationally Lensed Blazar PKS 1830-211 Observed by Fermi LAT

    NASA Astrophysics Data System (ADS)

    Abdo, A. A.; Ackermann, M.; Ajello, M.; Allafort, A.; Amin, M. A.; Baldini, L.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Blandford, R. D.; Bonamente, E.; Borgland, A. W.; Bregeon, J.; Brigida, M.; Buehler, R.; Bulmash, D.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caraveo, P. A.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Cheung, C. C.; Chiang, J.; Chiaro, G.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Conrad, J.; Corbet, R. H. D.; Cutini, S.; D'Ammando, F.; de Angelis, A.; de Palma, F.; Dermer, C. D.; Drell, P. S.; Drlica-Wagner, A.; Favuzzi, C.; Finke, J.; Focke, W. B.; Fukazawa, Y.; Fusco, P.; Gargano, F.; Gasparrini, D.; Gehrels, N.; Giglietto, N.; Giordano, F.; Giroletti, M.; Glanzman, T.; Grenier, I. A.; Grove, J. E.; Guiriec, S.; Hadasch, D.; Hayashida, M.; Hays, E.; Hughes, R. E.; Inoue, Y.; Jackson, M. S.; Jogler, T.; Jóhannesson, G.; Johnson, A. S.; Kamae, T.; Knödlseder, J.; Kuss, M.; Lande, J.; Larsson, S.; Latronico, L.; Longo, F.; Loparco, F.; Lott, B.; Lovellette, M. N.; Lubrano, P.; Madejski, G. M.; Mazziotta, M. N.; Mehault, J.; Michelson, P. F.; Mizuno, T.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nemmen, R.; Nuss, E.; Ohno, M.; Ohsugi, T.; Paneque, D.; Perkins, J. S.; Pesce-Rollins, M.; Piron, F.; Pivato, G.; Porter, T. A.; Rainò, S.; Rando, R.; Razzano, M.; Reimer, A.; Reimer, O.; Reyes, L. C.; Ritz, S.; Romoli, C.; Roth, M.; Saz Parkinson, P. M.; Sgrò, C.; Siskind, E. J.; Spandre, G.; Spinelli, P.; Takahashi, H.; Takeuchi, Y.; Tanaka, T.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Tibaldo, L.; Tinivella, M.; Torres, D. F.; Tosti, G.; Troja, E.; Tronconi, V.; Usher, T. L.; Vandenbroucke, J.; Vasileiou, V.; Vianello, G.; Vitale, V.; Waite, A. P.; Werner, M.; Winer, B. L.; Wood, K. S.

    2015-02-01

    The Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope routinely detects the MeV-peaked flat-spectrum radio quasar PKS 1830-211 (z = 2.507). Its apparent isotropic γ-ray luminosity (E > 100 MeV), averaged over ~3 years of observations and peaking on 2010 October 14/15 at 2.9 × 1050 erg s-1, makes it among the brightest high-redshift Fermi blazars. No published model with a single lens can account for all of the observed characteristics of this complex system. Based on radio observations, one expects time-delayed variability to follow about 25 days after a primary flare, with flux about a factor of 1.5 less. Two large γ-ray flares of PKS 1830-211 have been detected by the LAT in the considered period, and no substantial evidence for such a delayed activity was found. This allows us to place a lower limit of about 6 on the γ-ray flux ratio between the two lensed images. Swift XRT observations from a dedicated Target of Opportunity program indicate a hard spectrum with no significant correlation of X-ray flux with the γ-ray variability. The spectral energy distribution can be modeled with inverse Compton scattering of thermal photons from the dusty torus. The implications of the LAT data in terms of variability, the lack of evident delayed flare events, and different radio and γ-ray flux ratios are discussed. Microlensing effects, absorption, size and location of the emitting regions, the complex mass distribution of the system, an energy-dependent inner structure of the source, and flux suppression by the lens galaxy for one image path may be considered as hypotheses for understanding our results.

  14. Gamma-ray flaring activity from the gravitationally lensed blazar PKS 1830-211 observed by Fermi LAT

    DOE PAGES

    Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

    2015-01-23

    We present that the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope routinely detects the MeV-peaked flat-spectrum radio quasar PKS 1830–211 (z = 2.507). Its apparent isotropic γ-ray luminosity (E > 100 MeV), averaged over ~3 years of observations and peaking on 2010 October 14/15 at 2.9 × 10 50 erg s –1, makes it among the brightest high-redshift Fermi blazars. No published model with a single lens can account for all of the observed characteristics of this complex system. Based on radio observations, one expects time-delayed variability to follow about 25 days after a primary flare,more » with flux about a factor of 1.5 less. Two large γ-ray flares of PKS 1830–211 have been detected by the LAT in the considered period, and no substantial evidence for such a delayed activity was found. This allows us to place a lower limit of about 6 on the γ-ray flux ratio between the two lensed images. Swift XRT observations from a dedicated Target of Opportunity program indicate a hard spectrum with no significant correlation of X-ray flux with the γ-ray variability. The spectral energy distribution can be modeled with inverse Compton scattering of thermal photons from the dusty torus. The implications of the LAT data in terms of variability, the lack of evident delayed flare events, and different radio and γ-ray flux ratios are discussed. Lastly, microlensing effects, absorption, size and location of the emitting regions, the complex mass distribution of the system, an energy-dependent inner structure of the source, and flux suppression by the lens galaxy for one image path may be considered as hypotheses for understanding our results.« less

  15. Overexpression of L-Type Amino Acid Transporter 1 (LAT1) and 2 (LAT2): Novel Markers of Neuroendocrine Tumors

    PubMed Central

    Barollo, Susi; Bertazza, Loris; Watutantrige-Fernando, Sara; Censi, Simona; Cavedon, Elisabetta; Galuppini, Francesca; Pennelli, Gianmaria; Fassina, Ambrogio; Citton, Marilisa; Rubin, Beatrice; Pezzani, Raffaele; Benna, Clara; Opocher, Giuseppe; Iacobone, Maurizio; Mian, Caterina

    2016-01-01

    Background 6-18F-fluoro-L-3,4-dihydroxyphenylalanine (18F-FDOPA) PET is a useful tool in the clinical management of pheochromocytoma (PHEO) and medullary thyroid carcinoma (MTC). 18F-FDOPA is a large neutral amino acid biochemically resembling endogenous L-DOPA and taken up by the L-type amino acid transporters (LAT1 and LAT2). This study was conducted to examine the expression of the LAT system in PHEO and MTC. Methods Real-time PCR and Western blot analyses were used to assess LAT1 and LAT2 gene and protein expression in 32 PHEO, 38 MTC, 16 normal adrenal medulla and 15 normal thyroid tissue samples. Immunohistochemistry method was applied to identify the proteins’ subcellular localization. Results LAT1 and LAT2 were overexpressed in both PHEO and MTC by comparison with normal tissues. LAT1 presented a stronger induction than LAT2, and their greater expression was more evident in PHEO (15.1- and 4.1-fold increases, respectively) than in MTC (9.9- and 4.1-fold increases, respectively). Furthermore we found a good correlation between LAT1/2 and GLUT1 expression levels. A positive correlation was also found between urinary noradrenaline and adrenaline levels and LAT1 gene expression in PHEO. The increased expression of LAT1 is also confirmed at the protein level, in both PHEO and MTC, with a strong cytoplasmic localization. Conclusions The present study is the first to provide experimental evidence of the overexpression in some NET cancers (such as PHEO or MTC) of L-type amino acid transporters, and the LAT1 isoform in particular, giving the molecular basis to explain the increase of the DOPA uptake seen in such tumor cells. PMID:27224648

  16. MULTIWAVELENGTH OBSERVATIONS AND MODELING OF 1ES 1959+650 IN A LOW FLUX STATE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aliu, E.; Errando, M.; Archambault, S.

    We report on the VERITAS observations of the high-frequency peaked BL Lac object 1ES 1959+650 in the period 2007-2011. This source is detected at TeV energies by VERITAS at 16.4 standard deviation ({sigma}) significance in 7.6 hr of observation in a low flux state. A multiwavelength spectral energy distribution (SED) is constructed from contemporaneous data from VERITAS, Fermi-LAT, RXTE PCA, and Swift UVOT. Swift XRT data is not included in the SED due to a lack of simultaneous observations with VERITAS. In contrast to the orphan {gamma}-ray flare exhibited by this source in 2002, the X-ray flux of the sourcemore » is found to vary by an order of magnitude, while other energy regimes exhibit less variable emission. A quasi-equilibrium synchrotron self-Compton model with an additional external radiation field is used to describe three SEDs corresponding to the lowest, highest, and average X-ray states. The variation in the X-ray spectrum is modeled by changing the electron injection spectral index, with minor adjustments of the kinetic luminosity in electrons. This scenario produces small-scale flux variability of the order of {approx}< 2 in the high energy (E > 1 MeV) and very high energy (E > 100 GeV) {gamma}-ray regimes, which is corroborated by the Fermi-LAT, VERITAS, and Whipple 10 m telescope light curves.« less

  17. Sunward-propagating Solar Energetic Electrons inside Multiple Interplanetary Flux Ropes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gómez-Herrero, Raúl; Hidalgo, Miguel A.; Carcaboso, Fernando

    2017-05-10

    On 2013 December 2 and 3, the SEPT and STE instruments on board STEREO-A observed two solar energetic electron events with unusual sunward-directed fluxes. Both events occurred during a time interval showing typical signatures of interplanetary coronal mass ejections (ICMEs). The electron timing and anisotropies, combined with extreme-ultraviolet solar imaging and radio wave spectral observations, are used to confirm the solar origin and the injection times of the energetic electrons. The solar source of the ICME is investigated using remote-sensing observations and a three-dimensional reconstruction technique. In situ plasma and magnetic field data combined with energetic electron observations and amore » flux-rope model are used to determine the ICME magnetic topology and the interplanetary electron propagation path from the Sun to 1 au. Two consecutive flux ropes crossed the STEREO-A location and each electron event occurred inside a different flux rope. In both cases, the electrons traveled from the solar source to 1 au along the longest legs of the flux ropes still connected to the Sun. During the December 2 event, energetic electrons propagated along the magnetic field, while during the December 3 event they were propagating against the field. As found by previous studies, the energetic electron propagation times are consistent with a low number of field line rotations N < 5 of the flux rope between the Sun and 1 au. The flux rope model used in this work suggests an even lower number of rotations.« less

  18. Fermi-LAT observation of nonblazar AGNs

    NASA Astrophysics Data System (ADS)

    Sahakyan, N.; Baghmanyan, V.; Zargaryan, D.

    2018-06-01

    Context. Fermi Large Area Telescope (Fermi-LAT) has recently detected γ-ray emission from active galactic nuclei (AGN) that do not show clear evidence for optical blazar characteristics or have jets pointing away from the observer (nonblazar AGNs). These are interesting γ-ray emitters providing an alternative approach to studying high energy emission processes. Aims: This paper investigates the spectral and temporal properties of γ-ray emission from nonblazar AGNs using the recent Fermi-LAT observational data. Methods: The data collected by Fermi-LAT during 2008-2015, from the observations of 26 nonblazar AGNs, including 11 Fanaroff-Riley Type I (FRI) and ten FRII radio galaxies and steep spectrum radio quasars (SSRQs) and five narrow line seyfert 1s (NLSy1s) are analysed using the new PASS 8 event selection and instrument response function. Possible spectral changes above GeV energies are investigated with a detailed spectral analysis. Light curves generated with normal and adaptive time bins are used to study the γ-ray flux variability. Results: Non-blazar AGNs have a γ-ray photon index in the range of 1.84-2.86 and a flux varying from a few times 10-9 photon cm-2 s-1 to 10-7 photon cm-2 s-1. Over long time periods, the power law provides an adequate description of the γ-ray spectra of almost all sources. Significant curvature is observed in the γ-ray spectra of NGC 1275, NGC 6251, SBS 0846 + 513, and PMN J0948 + 0022 and their spectra are better described by log parabola or by the power law with exponential cut-off models. The γ-ray spectra of PKS 0625-25 and 3C 380 show a possible deviation from a simple power-law shape, indicating a spectral cut-off around the observed photon energy of Ecut = 131.2 ± 88.04 GeV and Ecut = 55.57 ± 50.74 GeV, respectively. Our analysis confirms the previous finding of an unusual spectral turnover in the γ-ray spectrum of Cen A: the photon index changes from Γ = 2.75 ± 0.02 to 2.31 ± 0.1 at 2.35 ± 0.08 GeV. In the

  19. Millisecond resolution electron fluxes from the Cluster satellites: Calibrated EDI ambient electron data

    NASA Astrophysics Data System (ADS)

    Förster, Matthias; Rashev, Mikhail; Haaland, Stein

    2017-04-01

    The Electron Drift Instrument (EDI) onboard Cluster can measure 500 eV and 1 keV electron fluxes with high time resolution during passive operation phases in its Ambient Electron (AE) mode. Data from this mode is available in the Cluster Science Archive since October 2004 with a cadence of 16 Hz in the normal mode or 128 Hz for burst mode telemetry intervals. The fluxes are recorded at pitch angles of 0, 90, and 180 degrees. This paper describes the calibration and validation of these measurements. The high resolution AE data allow precise temporal and spatial diagnostics of magnetospheric boundaries and will be used for case studies and statistical studies of low energy electron fluxes in the near-Earth space. We show examples of applications.

  20. Increased neurovirulence and reactivation of the herpes simplex virus type 1 latency associated transcript (LAT) negative mutant dLAT2903 with a disrupted LAT miR-H2

    PubMed Central

    Jiang, Xianzhi; Brown, Don; Osorio, Nelson; Hsiang, Chinhui; BenMohamed, Lbachir; Wechsler, Steven L.

    2015-01-01

    At least six microRNAs (miRNAs) appear to be encoded by the latency associated transcript (LAT) of herpes simplex virus type 1 (HSV-1). The gene for ICP0, an important immediate early (IE) viral protein, is antisense to, and overlaps with, the region of LAT from which miRNA H2 (miR-H2) is derived. We recently reported that a mutant (McK-ΔH2) disrupted for miR-H2 on the wild type HSV-1 strain McKrae genomic background has increased ICP0 expression, increased neurovirulence, and slightly more rapid reactivation. We report here that HSV-1 mutants deleted for the LAT promoter nonetheless make significant amounts of miR-H2 during lytic tissue culture infection, presumably via readthrough transcription from an upstream promoter. To determine if miR-H2 might also play a role in the HSV-1 latency-reactivation cycle of a LAT negative mutant, we constructed dLAT-ΔH2, in which miR-H2 is disrupted in dLAT2903 without altering the predicted amino acid sequence of the overlapping ICP0 open reading frame. Similar to McK-ΔH2, dLAT-ΔH2 expressed more ICP0, was more neurovirulent, and had increased reactivation in the mouse TG explant induced reactivation model of HSV-1 compared to its parental virus. Interestingly, although the increased reactivation of McK-ΔH2 compared to its parental wt virus was subtle and only detected at very early times after explant TG induced reactivation, the increased reactivation of dLAT-ΔH2 compared to its dLAT2903 parental virus appeared more robust and was significantly increased even at late times after induction. These results confirm that miR-H2 plays a role in modulating the HSV-1 reactivation phenotype. PMID:26069184

  1. Forecast the energetic electron flux on geosynchronous orbit with interplanetary parameters

    NASA Astrophysics Data System (ADS)

    Xue, B.; Ye, Z.

    The high flux of energetic electron on geo-synchronous orbit can cause many kinds of malfunction of the satellite there, within which the bulk charging is the most significant that several broadcast satellite failures were confirmed to be due to this effect. The electron flux on geo-synchronous orbit varies in a large range even up to three orders accompanied the passage of interplanetary magnetic cloud and the following geomagnetic disturbances. Upon investigating electron flux, interplanetary solar wind data, and geomagnetic data as well, we found that: (1) The enhancement of energetic flux on the geo-synchronous orbit exhibits periodic recurrence of 27days. (2)Significant increase of electron flux relates to interplanetary index and characters of their distribution. (3)The electron flux also has relation to solar activity index. In our research work, artificial neural network was employed and constructed according to the job. The neural network, we call it full connecting network, was proved to be a sufficient tool to analyze the character of the evolving parameters, remember the omen of "electron storm", and establish the relationship between interplanetary parameters etc., and the fluence of high energetic electrons. The neural network was carefully constructed and trained to do the job mentioned above. Preliminary result showed that the accuracy forecast of electron flux 1 day ahead can reach 80%, and 70% for 2 days ahead.

  2. Search for Gamma-Ray Emission from the Coma Cluster with Six Years of Fermi-LAT Data

    NASA Technical Reports Server (NTRS)

    Ackermann, M.; Ajello, M.; Albert, A.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; hide

    2016-01-01

    We present results from gamma-ray observations of the Coma cluster incorporating six years of Fermi-LAT data and the newly released 'Pass 8' event-level analysis. Our analysis of the region reveals low-significance residual structures within the virial radius of the cluster that are too faint for a detailed investigation with the current data. Using a likelihood approach that is free of assumptions on the spectral shape we derive upper limits on the gamma-ray flux that is expected from energetic particle interactions in the cluster. We also consider a benchmark spatial and spectral template motivated by models in which the observed radio halo is mostly emission by secondary electrons. In this case, the median expected and observed upper limits for the flux above 100 MeV are 1.7 x 10(exp -9) ph cm(exp -2) s(exp -1) and 5.2 x 10(exp -9) ph cm(exp -2) s(exp -1) respectively (the latter corresponds to residual emission at the level of 1.8sigma). These bounds are comparable to or higher than predicted levels of hadronic gamma-ray emission in cosmic-ray (CR) models with or without reacceleration of secondary electrons, although direct comparisons are sensitive to assumptions regarding the origin and propagation mode of CRs and magnetic field properties. The minimal expected gamma-ray flux from radio and star-forming galaxies within the Coma cluster is roughly an order of magnitude below the median sensitivity of our analysis.

  3. Search for gamma-ray emission from the Coma Cluster with six years of Fermi-LAT data

    DOE PAGES

    Ackermann, M.

    2016-03-08

    We present results from γ-ray observations of the Coma cluster incorporating 6 years of Fermi-LAT data and the newly released “Pass 8” event-level analysis. Our analysis of the region reveals low-significance residual structures within the virial radius of the cluster that are too faint for a detailed investigation with the current data. Using a likelihood approach that is free of assumptions on the spectral shape we derive upper limits on the γ-ray flux that is expected from energetic particle interactions in the cluster. We also consider a benchmark spatial and spectral template motivated by models in which the observed radiomore » halo is mostly emission by secondary electrons. In this case, the median expected and observed upper limits for the flux above 100MeV are 1.7 x 10 -9 ph cm -2 s -1 and 5.2 x 10 -9 ph cm -2 s -1 respectively (the latter corresponds to residual emission at the level of 1:8σ). These bounds are comparable to or higher than predicted levels of hadronic gamma-ray emission in cosmic-ray models with or without reacceleration of secondary electrons, although direct comparisons are sensitive to assumptions regarding the origin and propagation mode of cosmic rays and magnetic field properties. The minimal expected γ-ray flux from radio and star-forming galaxies within the Coma cluster is roughly an order of magnitude below the median sensitivity of our analysis.« less

  4. DAMPE electron-positron excess in leptophilic Z' model

    NASA Astrophysics Data System (ADS)

    Ghorbani, Karim; Ghorbani, Parsa Hossein

    2018-05-01

    Recently the DArk Matter Particle Explorer (DAMPE) has reported an excess in the electron-positron flux of the cosmic rays which is interpreted as a dark matter particle with the mass about 1.5 TeV. We come up with a leptophilic Z' scenario including a Dirac fermion dark matter candidate which beside explaining the observed DAMPE excess, is able to pass various experimental/observational constraints including the relic density value from the WMAP/Planck, the invisible Higgs decay bound at the LHC, the LEP bounds in electron-positron scattering, the muon anomalous magnetic moment constraint, Fermi-LAT data, and finally the direct detection experiment limits from the XENON1t/LUX. By computing the electron-positron flux produced from a dark matter with the mass about 1.5 TeV we show that the model predicts the peak observed by the DAMPE.

  5. NuLat: A Novel Design for a Reactor Anti-Neutrino Detector

    NASA Astrophysics Data System (ADS)

    Rountree, S. Derek; NuLat Collaboration

    2015-04-01

    NuLat is a proposed very-short baseline (3-10m) reactor electron antineutrino (anti-νe) experiment that will probe the current best fit for light sterile neutrino mixing, the 5 MeV excess seen in current short baseline reactor experiments, and serve as a portable surface detector for cooperative (~ 30m baseline) surface monitoring of reactors. The NuLat detector will use an optically segmented 3D Raghavan optical lattice (ROL) detector that channels light via total internal reflection from a scintillation event down the 3 primary axes to the detector faces. The high degree of segmentation allows for each voxel's energy to be determined independently of other voxels, thus providing high temporal and spatial resolution and energy reconstruction independent of position. NuLat detects anti-νe via inverse beta decay (IBD), which produces a positron and a neutron. Most of the time, the positron deposits its kinetic energy into a single voxel allowing superior derivation of the incident anti-νe's energy. The final state neutron is captured via (n, α) on 6 Li or 10 B after a characteristic delay time giving a coincidence tag. This talk will discuss the physics reach of NuLat using a solid loaded scintillator, and the timeline of the NuLat reactor anti-νe program. This research has been funded in part by the National Science Foundation on Award Numbers 1001394 and 1001078.

  6. Effective doses and organ doses in the MIRD-5 phantom exposed to monoenergetic 0.1 MeV to 200 MeV electrons in the LAT direction.

    PubMed

    Katagiri, M; Hikoji, M; Kitaichi, M; Aoki, Y; Sawamura, S

    2001-01-01

    Organ doses and effective doses were calculated using the EGS-4 Monte Carlo simulation code and a MIRD-5 mathematical human phantom placed in a vacuum. For broad right and left lateral beams of monoenergetic (0.1-200 MeV) electrons, conversion coefficients from the incident fluence to organ dose, to effective dose, and to effective dose equivalent were obtained. There were no clear differences between the conversion coefficients in the case of left-lateral (LLAT) and right-lateral (RLAT) irradiation. Therefore, when investigating lateral geometries for electron exposure, it is not necessary to evaluate both directions independently. In general, conversion coefficients for lateral irradiation (LAT) were smaller than those for AP and PA. The difference between the AP and PA conversion coefficients and LAT became smaller with increasing incident energy; at 200 MeV the conversion coefficients were almost independent of the irradiation geometry. The agreement between the results of the present study and those of other studies was acceptable within the statistical uncertainties.

  7. A PLC-γ1-independent, RasGRP1-ERK dependent pathway drives lymphoproliferative disease in LAT-Y136F mutant mice

    PubMed Central

    Kortum, Robert L.; Rouquette-Jazdanian, Alexandre K.; Miyaji, Michihiko; Merrill, Robert K.; Markegard, Evan; Pinski, John M.; Wesselink, Amelia; Nath, Nandan N.; Alexander, Clayton P.; Li, Wenmei; Kedei, Noemi; Roose, Jeroen P.; Blumberg, Peter M.; Samelson, Lawrence E.; Sommers, Connie L.

    2012-01-01

    Mice expressing a germline mutation in the PLC-γ1 binding site of LAT (linker for activation of T cells) show progressive lymphoproliferation and ultimately die at 4–6 months of age. The hyper-activated T cells in these mice show defective TCR-induced calcium flux, but enhanced Ras/ERK activation that is critical for disease progression. Despite the loss of LAT-dependent PLC-γ1 binding and activation, genetic analysis revealed RasGRP1, and not Sos1 or Sos2, to be the major RasGEF responsible for ERK activation and the lymphoproliferative phenotype in these mice. Analysis of isolated CD4+ T cells from LAT-Y136F mice showed altered proximal TCR-dependent kinase signaling, which activated a Zap70- and LAT-independent pathway. Moreover, LAT-Y136F T cells showed ERK activation that was dependent on Lck and/or Fyn, PKCθ, and RasGRP1. These data demonstrate a novel route to Ras activation in vivo in a pathological setting. PMID:23209318

  8. Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan.

    PubMed

    Kühne, Annett; Kaiser, Rolf; Schirmer, Markus; Heider, Ulrike; Muhlke, Sabine; Niere, Wiebke; Overbeck, Tobias; Hohloch, Karin; Trümper, Lorenz; Sezer, Orhan; Brockmöller, Jürgen

    2007-07-01

    Melphalan is widely used in the treatment of multiple myeloma. Pharmacokinetics of this alkylating drug shows high inter-individual variability. As melphalan is a phenylalanine derivative, the pharmacokinetic variability may be determined by genetic polymorphisms in the L-type amino acid transporters LAT1 (SLC7A5) and LAT2 (SLC7A8). Pharmacokinetics were analysed in 64 patients after first administration of intravenous melphalan. Severity of side effects was documented according to WHO criteria. Genomic DNA was analysed for polymorphisms in LAT1 and LAT2 by sequencing of the entire coding region, intron-exon boundaries and 2 kb upstream promoter region. Selected polymorphisms in the common heavy chain of both transporters, the protein 4F2hc (SLC3A2), were analysed by single nucleotide primer extension. Melphalan pharmacokinetics was highly variable with up to 6.2-fold differences in total clearance. A total of 44 polymorphisms were identified in LAT1 and 21 polymorphisms in LAT2. From all variants, only five were in the coding region and only one heterozygous non-synonymous polymorphism (Ala94Thr) was found in LAT2. Numerous polymorphisms were found in the LAT1 and LAT2 5'-flanking regions but did not correlate with expression of the respective genes. No significant correlations could be observed between the polymorphisms in 4F2hc, LAT1, and LAT2 with melphalan pharmacokinetics or with melphalan side effects. The study confirmed that these transporter genes are highly conserved, particularly in the coding sequences. Genetic variation in 4F2hc, LAT1, and LAT2 does not appear to be a major cause of inter-individual variability in pharmacokinetics and of adverse reactions to melphalan.

  9. Fermi LAT detection of an increase in gamma-ray activity of the FSRQ S5 1044+71

    NASA Astrophysics Data System (ADS)

    Ojha, Roopesh; Carpen, Bryce

    2017-01-01

    The Large Area Telescope (LAT), on board the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar S5 1044+71 (also known as 3FGL J1048.4+7144, Acero et al. 2015, ApJS 218, 23) with radio coordinates R.A: 10h48m27.6199s, Dec: +71d43m35.938s (J2000; Johnston et al. 1995, AJ, 110, 880) and redshift z=1.15 (Polatidis et al. 1995, ApJS, 98, 1). Preliminary results indicate that S5 1044+71 showed a marked increase in activity on 2016 December 29, with a daily flux (E > 100 MeV) of (1.1+/-0.2) x10^-6 ph cm^-2 s^-1 (errors are statistical only) which is a factor of about 16 greater than the average flux reported in the third Fermi LAT catalog (3FGL).

  10. Frozen flux violation, electron demagnetization and magnetic reconnection

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Scudder, J. D.; Karimabadi, H.; Roytershteyn, V.

    2015-10-15

    We argue that the analogue in collisionless plasma of the collisional diffusion region of magnetic reconnection is properly defined in terms of the demagnetization of the plasma electrons that enable “frozen flux” slippage to occur. This condition differs from the violation of the “frozen-in” condition, which only implies that two fluid effects are involved, rather than the necessary slippage of magnetic flux as viewed in the electron frame. Using 2D Particle In Cell (PIC) simulations, this approach properly finds the saddle point region of the flux function. Our demagnetization conditions are the dimensionless guiding center approximation expansion parameters for electronsmore » which we show are observable and determined locally by the ratio of non-ideal electric to magnetic field strengths. Proxies for frozen flux slippage are developed that (a) are measurable on a single spacecraft, (b) are dimensionless with theoretically justified threshold values of significance, and (c) are shown in 2D simulations to recover distinctions theoretically possible with the (unmeasurable) flux function. A new potentially observable dimensionless frozen flux rate, Λ{sub Φ}, differentiates significant from anecdotal frozen flux slippage. A single spacecraft observable, ϒ, is shown with PIC simulations to be essentially proportional to the unobservable local Maxwell frozen flux rate. This relationship theoretically establishes electron demagnetization in 3D as the general cause of frozen flux slippage. In simple 2D cases with an isolated central diffusion region surrounded by separatrices, these diagnostics uniquely identify the traditional diffusion region (without confusing it with the two fluid “ion-diffusion” region) and clarify the role of the separatrices where frozen flux violations do occur but are not substantial. In the more complicated guide and asymmetric 2D cases, substantial flux slippage regions extend out along, but inside of, the preferred

  11. Inter-satellite calibration of FengYun 3 medium energy electron fluxes with POES electron measurements

    NASA Astrophysics Data System (ADS)

    Zhang, Yang; Ni, Binbin; Xiang, Zheng; Zhang, Xianguo; Zhang, Xiaoxin; Gu, Xudong; Fu, Song; Cao, Xing; Zou, Zhengyang

    2018-05-01

    We perform an L-shell dependent inter-satellite calibration of FengYun 3 medium energy electron measurements with POES measurements based on rough orbital conjunctions within 5 min × 0.1 L × 0.5 MLT. By comparing electron flux data between the U.S. Polar Orbiting Environmental Satellites (POES) and Chinese sun-synchronous satellites including FY-3B and FY-3C for a whole year of 2014, we attempt to remove less reliable data and evaluate systematic uncertainties associated with the FY-3B and FY-3C datasets, expecting to quantify the inter-satellite calibration factors for the 150-350 keV energy channel at L = 2-7. Compared to the POES data, the FY-3B and FY-3C data generally exhibit a similar trend of electron flux variations but more or less underestimate them within a factor of 5 for the medium electron energy 150-350 keV channel. Good consistency in the flux conjunctions after the inter-calibration procedures gives us certain confidence to generalize our method to calibrate electron flux measurements from various satellite instruments.

  12. Development of nanoscale structure in LAT-based signaling complexes

    PubMed Central

    2016-01-01

    ABSTRACT The adapter molecule linker for activation of T cells (LAT) plays a crucial role in forming signaling complexes induced by stimulation of the T cell receptor (TCR). These multi-molecular complexes are dynamic structures that activate highly regulated signaling pathways. Previously, we have demonstrated nanoscale structure in LAT-based complexes where the adapter SLP-76 (also known as LCP2) localizes to the periphery of LAT clusters. In this study, we show that initially LAT and SLP-76 are randomly dispersed throughout the clusters that form upon TCR engagement. The segregation of LAT and SLP-76 develops near the end of the spreading process. The local concentration of LAT also increases at the same time. Both changes require TCR activation and an intact actin cytoskeleton. These results demonstrate that the nanoscale organization of LAT-based signaling complexes is dynamic and indicates that different kinds of LAT-based complexes appear at different times during T cell activation. PMID:27875277

  13. NuLat: 3D Event Reconstruction of a ROL Detector for Neutrino Detection and Background Rejection

    NASA Astrophysics Data System (ADS)

    Yokley, Zachary; NuLat Collaboration

    2015-04-01

    NuLat is a proposed very-short baseline reactor antineutrino experiment that employs a unique detector design, a Ragahavan Optical Lattice (ROL), developed for the LENS solar neutrino experiment. The 3D lattice provides high spatial and temporal resolution and allows for energy deposition in each voxel to be determined independently of other voxels, as well as the time sequence associated with each voxel energy deposition. This unique feature arises from two independent means to spatially locate energy deposits: via timing and via optical channeling. NuLat, the first application of a ROL detector targeting physics results, will measure the reactor antineutrino flux at very short baselines via inverse beta decay (IBD). The ROL design of NuLat makes possible the reconstruction of positron energy with little contamination due to the annihilation gammas which smear the positron energy resolution in a traditional detector. IBD events are cleanly tagged via temporal and spatial coincidence of neutron capture in the vertex voxel or nearest neighbors. This talk will present work on IBD event reconstruction in NuLat and its likely impact on sterile neutrino detection via operation in higher background locations enabled by its superior rejection of backgrounds. This research has been funded in part by the National Science Foundation on Award Numbers 1001394 and 1001078.

  14. Involvement of LAT1 and LAT2 in the high- and low-affinity transport of L-leucine in human retinal pigment epithelial cells (ARPE-19 cells).

    PubMed

    Yamamoto, Atsushi; Akanuma, Shin-Ichi; Tachikawa, Masanori; Hosoya, Ken-Ichi

    2010-05-01

    System L, which is encoded by LAT1 and LAT2, is an amino acid transport system that transports neutral amino acids, including several essential amino acids in an Na+-independent manner. Due to its broad substrate selectivity, system L has been proposed to mediate the transport of amino-acid-related drugs across the blood-tissue barriers. We characterized L-leucine transport and its corresponding transporter in a human retinal pigment epithelial cell line (ARPE-19 cells) as an in vitro model of the outer blood-retinal barrier. [3H]L-leucine uptake by ARPE-19 cells took place in an Na+-, Cl(-)-independent and saturable manner with K(m) values of 8.71 and 220 microM. This process was more potently cis-inhibited by substrates of LAT1 than those of LAT2. [3H]L-leucine efflux from ARPE-19 cells was trans-stimulated by substrates of LAT1 and LAT2 through the obligatory exchange mechanism of system L. Although RT-PCR analysis demonstrated that LAT1 and LAT2 mRNA are expressed in ARPE-19 cells, the LAT1 mRNA concentration is 42-fold higher than that of LAT2. Moreover, immunoblot analysis demonstrated that LAT1 is expressed in ARPE-19 cells. In conclusion, although the transport function of LAT1 is greater than that of LAT2, LAT1 and LAT2 are involved in L-leucine transport in ARPE-19 cells.

  15. Detection of the Small Magellanic Cloud in gamma-rays with Fermi/LAT

    NASA Astrophysics Data System (ADS)

    Abdo, A. A.; Ackermann, M.; Ajello, M.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Berenji, B.; Blandford, R. D.; Bloom, E. D.; Bonamente, E.; Borgland, A. W.; Bouvier, A.; Brandt, T. J.; Bregeon, J.; Brez, A.; Brigida, M.; Bruel, P.; Buehler, R.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caraveo, P. A.; Carrigan, S.; Casandjian, J. M.; Cecchi, C.; Çelik, Ö.; Charles, E.; Chekhtman, A.; Cheung, C. C.; Chiang, J.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Conrad, J.; Dermer, C. D.; de Palma, F.; Digel, S. W.; Silva, E. Do Couto E.; Drell, P. S.; Dubois, R.; Dumora, D.; Favuzzi, C.; Fegan, S. J.; Fukazawa, Y.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Gehrels, N.; Germani, S.; Giglietto, N.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Grenier, I. A.; Grondin, M.-H.; Grove, J. E.; Guiriec, S.; Hadasch, D.; Harding, A. K.; Hayashida, M.; Hays, E.; Horan, D.; Hughes, R. E.; Jean, P.; Jóhannesson, G.; Johnson, A. S.; Johnson, W. N.; Kamae, T.; Katagiri, H.; Kataoka, J.; Kerr, M.; Knödlseder, J.; Kuss, M.; Lande, J.; Latronico, L.; Lee, S.-H.; Lemoine-Goumard, M.; Llena Garde, M.; Longo, F.; Loparco, F.; Lovellette, M. N.; Lubrano, P.; Makeev, A.; Martin, P.; Mazziotta, M. N.; McEnery, J. E.; Michelson, P. F.; Mitthumsiri, W.; Mizuno, T.; Monte, C.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nakamori, T.; Naumann-Godo, M.; Nolan, P. L.; Norris, J. P.; Nuss, E.; Ohsugi, T.; Okumura, A.; Omodei, N.; Orlando, E.; Ormes, J. F.; Panetta, J. H.; Parent, D.; Pelassa, V.; Pepe, M.; Pesce-Rollins, M.; Piron, F.; Porter, T. A.; Rainò, S.; Rando, R.; Razzano, M.; Reimer, A.; Reimer, O.; Reposeur, T.; Ripken, J.; Ritz, S.; Romani, R. W.; Sadrozinski, H. F.-W.; Sander, A.; Saz Parkinson, P. M.; Scargle, J. D.; Sgrò, C.; Siskind, E. J.; Smith, D. A.; Smith, P. D.; Spandre, G.; Spinelli, P.; Strickman, M. S.; Strong, A. W.; Suson, D. J.; Takahashi, H.; Takahashi, T.; Tanaka, T.; Thayer, J. B.; Thayer, J. G.; Thompson, D. J.; Tibaldo, L.; Torres, D. F.; Tosti, G.; Tramacere, A.; Uchiyama, Y.; Usher, T. L.; Vandenbroucke, J.; Vasileiou, V.; Vilchez, N.; Vitale, V.; Waite, A. P.; Wang, P.; Winer, B. L.; Wood, K. S.; Yang, Z.; Ylinen, T.; Ziegler, M.

    2010-11-01

    Context. The flux of gamma rays with energies greater than 100 MeV is dominated by diffuse emission coming from cosmic-rays (CRs) illuminating the interstellar medium (ISM) of our Galaxy through the processes of Bremsstrahlung, pion production and decay, and inverse-Compton scattering. The study of this diffuse emission provides insight into the origin and transport of cosmic rays. Aims: We searched for gamma-ray emission from the Small Magellanic Cloud (SMC) in order to derive constraints on the cosmic-ray population and transport in an external system with properties different from the Milky Way. Methods: We analysed the first 17 months of continuous all-sky observations by the Large Area Telescope (LAT) of the Fermi mission to determine the spatial distribution, flux and spectrum of the gamma-ray emission from the SMC. We also used past radio synchrotron observations of the SMC to study the population of CR electrons specifically. Results: We obtained the first detection of the SMC in high-energy gamma rays, with an integrated >100 MeV flux of (3.7±0.7) × 10-8 ph cm-2 s-1, with additional systematic uncertainty of ≤16%. The emission is steady and from an extended source ~3° in size. It is not clearly correlated with the distribution of massive stars or neutral gas, nor with known pulsars or supernova remnants, but a certain correlation with supergiant shells is observed. Conclusions: The observed flux implies an upper limit on the average CR nuclei density in the SMC of ~15% of the value measured locally in the Milky Way. The population of high-energy pulsars of the SMC may account for a substantial fraction of the gamma-ray flux, which would make the inferred CR nuclei density even lower. The average density of CR electrons derived from radio synchrotron observations is consistent with the same reduction factor but the uncertainties are large. From our current knowledge of the SMC, such a low CR density does not seem to be due to a lower rate of CR

  16. Beta electron fluxes inside a magnetic plasma cavern: Calculation and comparison with experiment

    NASA Astrophysics Data System (ADS)

    Stupitskii, E. L.; Smirnov, E. V.; Kulikova, N. A.

    2010-12-01

    We study the possibility of electrostatic blanking of beta electrons in the expanding spherical blob of a radioactive plasma in a rarefied ionosphere. From numerical studies on the dynamics of beta electrons departing a cavern, we obtain the form of a function that determines the portion of departing electrons and calculate the flux density of beta electrons inside the cavern in relation to the Starfish Prime nuclear blast. We show that the flux density of electrons in geomagnetic flux tubes and inside the cavern depend on a correct allowance for the quantity of beta electrons returning to the cavern. On the basis of a physical analysis, we determine the approximate criterion for the return of electrons from a geomagnetic flux tube to the cavern. We compare calculation results in terms of the flux density of beta electrons inside the cavern with the recently published experimental results from operation Starfish Prime.

  17. Latency-associated transcript (LAT) exon 1 controls herpes simplex virus species-specific phenotypes: reactivation in the guinea pig genital model and neuron subtype-specific latent expression of LAT.

    PubMed

    Bertke, Andrea S; Patel, Amita; Imai, Yumi; Apakupakul, Kathleen; Margolis, Todd P; Krause, Philip R

    2009-10-01

    Herpes simplex virus 1 (HSV-1) and HSV-2 cause similar acute infections but differ in their abilities to reactivate from trigeminal and lumbosacral dorsal root ganglia. During latency, HSV-1 and HSV-2 also preferentially express their latency-associated transcripts (LATs) in different sensory neuronal subtypes that are positive for A5 and KH10 markers, respectively. Chimeric virus studies showed that LAT region sequences influence both of these viral species-specific phenotypes. To further map the LAT region sequences responsible for these phenotypes, we constructed the chimeric virus HSV2-LAT-E1, in which exon 1 (from the LAT TATA to the intron splice site) was replaced by the corresponding sequence from HSV-1 LAT. In intravaginally infected guinea pigs, HSV2-LAT-E1 reactivated inefficiently relative to the efficiency of its rescuant and wild-type HSV-2, but it yielded similar levels of viral DNA, LAT, and ICP0 during acute and latent infection. HSV2-LAT-E1 preferentially expressed the LAT in A5+ neurons (as does HSV-1), while the chimeric viruses HSV2-LAT-P1 (LAT promoter swap) and HSV2-LAT-S1 (LAT sequence swap downstream of the promoter) exhibited neuron subtype-specific latent LAT expression phenotypes more similar to that of HSV-2 than that of HSV-1. Rescuant viruses displayed the wild-type HSV-2 phenotypes of efficient reactivation in the guinea pig genital model and a tendency to express LAT in KH10+ neurons. The region that is critical for HSV species-specific differences in latency and reactivation thus lies between the LAT TATA and the intron splice site, and minor differences in the 5' ends of chimeric sequences in HSV2-LAT-E1 and HSV2-LAT-S1 point to sequences immediately downstream of the LAT TATA.

  18. Activated PLC-γ1 is Catalytically Induced at LAT but Activated PLC-γ1 is Localized at both LAT- and TCR-Containing Complexes

    PubMed Central

    Cruz-Orcutt, Noemi; Vacaflores, Aldo; Connolly, Sean F.; Bunnell, Stephen C.; Houtman, Jon C.D.

    2014-01-01

    Phospholipase C-γ1 (PLC-γ1) is a key regulator of T cell receptor (TCR)-induced signaling. Activation of the TCR enhances PLC-γ1 enzymatic function, resulting in calcium influx and the activation of PKC family members and RasGRP. The current model is that phosphorylation of LAT tyrosine 132 facilitates the recruitment of PLC-γ1, leading to its activation and function at the LAT complex. In this study, we examined the phosphorylation kinetics of LAT and PLC-γ1 and the cellular localization of activated PLC-γ1. We observed that commencement of the phosphorylation of LAT tyrosine 132 and PLC-γ1 tyrosine 783 occurred simultaneously, supporting the current model. However, once begun, PLC-γ1 activation occurred more rapidly than LAT tyrosine 132. The association of LAT and PLC-γ1 was more transient than the interaction of LAT and Grb2 and a pool of activated PLC-γ1 translocated away from LAT to cellular structures containing the TCR. These studies demonstrate that LAT and PLC-γ1 form transient interactions that catalyze the activation of PLC-γ1, but that activated PLC-γ1 resides in both LAT and TCR clusters. Together, this work highlights that our current model is incomplete and the activation and function of PLC-γ1 in T cells is highly complex. PMID:24412752

  19. Communication: Electronic flux induced by crossing the transition state

    NASA Astrophysics Data System (ADS)

    Jia, Dongming; Manz, Jörn; Yang, Yonggang

    2018-01-01

    We present a new effect of chemical reactions, e.g., isomerizations, that occurs when the reactants pass along the transition state, on the way to products. It is based on the well-known fact that at the transition state, the electronic structure of one isomer changes to the other. We discover that this switch of electronic structure causes a strong electronic flux that is well distinguishable from the usual flux of electrons that travel with the nuclei. As a simple but clear example, the effect is demonstrated here for bond length isomerization of Na2 (21Σu+), with adiabatic crossing the barrier between the inner and outer wells of the double minimum potential that support different "Rydberg" and "ionic" type electronic structures, respectively.

  20. GUST LAT Multiwavelength Planning

    NASA Technical Reports Server (NTRS)

    Thompson, D. J.

    2004-01-01

    Because gamma-ray astrophysics profits in powerful ways from multi-wavelength studies, the GLAST Large Area Telescope (LAT) Collaboration has started multiwavelength planning well before the scheduled 2007 launch. Many aspects of this program are of direct interest to observers using VERITAS and other atmospheric Cerenkov telescopes, whose capabilities complement those of GLAST. This talk with describe some of the current developmental concepts for GLAST LAT multiwavelength work, including release of data for transient sources, nearly-continuous monitoring of selected time-variable sources, pulsar timing, follow-on observations for source identification, coordinated blazar campaigns, and cross-calibration with other high-energy telescopes. Although few details are firm at this stage of preparation for GLAST, the LAT Collaboration looks forward to cooperation with a broad cross-section of the multiwave-length community. The GLAST Large Area Telescope is an international effort, with U.S. funding provided by the Department of Energy and NASA.

  1. Intrinsic Magnetic Flux of the Electron's Orbital and Spin Motion

    NASA Astrophysics Data System (ADS)

    Wan, K. K.; Saglam, M.

    2006-06-01

    In analogy with the fact that there are magnetic moments associated respectively with the electron's orbital and spin motion in an atom we present several analyses on a proposal to introduce a concept of intrinsic magnetic flux associated with the electron's orbital and spin motion. It would be interesting to test or to demonstrate Faraday's and Lenz's laws of electromagnetic induction arising directly from the flux change due to transition of states in an atom and to examine applications of this concept of intrinsic flux.

  2. Temporal Characteristics of Electron Flux Events at Geosynchronous Orbit

    NASA Astrophysics Data System (ADS)

    Olson, D. K.; Larsen, B.; Henderson, M. G.

    2017-12-01

    Geosynchronous satellites such as the LANL-GEO fleet are exposed to hazardous conditions when they encounter regions of hot, intense plasma such as that from the plasma sheet. These conditions can lead to the build-up of charge on the surface of a spacecraft, with undesired, and often dangerous, side effects. Observation of electron flux levels at geosynchronous orbit (GEO) with multiple satellites provides a unique view of plasma sheet access to that region. Flux "events", or periods when fluxes are elevated continuously above the LANL-GEO spacecraft charging threshold, can be characterized by duration in two dimensions: a spatial dimension of local time, describing the duration of an event from the perspective of a single spacecraft, and a temporal dimension describing the duration in time in which high energy plasma sheet particles have access to geosynchronous orbit. We examine the statistical properties of the temporal duration of 8 keV electron flux events at geosynchronous orbit over a twelve-year period. These results, coupled with the spatial duration characteristics, provide the key information needed to formulate a statistical model for forecasting the electron flux conditions at GEO that are correlated with LANL-GEO surface charging. Forecasting models are an essential component to understanding space weather and mitigating the dangers of surface charging on our satellites. We also examine the correlation of flux event durations with solar wind parameters and geomagnetic indices, identifying the data needed to improve upon a statistical forecasting model

  3. A statistical approach to determining energetic outer radiation belt electron precipitation fluxes

    NASA Astrophysics Data System (ADS)

    Simon Wedlund, Mea; Clilverd, Mark A.; Rodger, Craig J.; Cresswell-Moorcock, Kathy; Cobbett, Neil; Breen, Paul; Danskin, Donald; Spanswick, Emma; Rodriguez, Juan V.

    2014-05-01

    Subionospheric radio wave data from an Antarctic-Arctic Radiation-Belt (Dynamic) Deposition VLF Atmospheric Research Konsortia (AARDDVARK) receiver located in Churchill, Canada, is analyzed to determine the characteristics of electron precipitation into the atmosphere over the range 3 < L < 7. The study advances previous work by combining signals from two U.S. transmitters from 20 July to 20 August 2010, allowing error estimates of derived electron precipitation fluxes to be calculated, including the application of time-varying electron energy spectral gradients. Electron precipitation observations from the NOAA POES satellites and a ground-based riometer provide intercomparison and context for the AARDDVARK measurements. AARDDVARK radiowave propagation data showed responses suggesting energetic electron precipitation from the outer radiation belt starting 27 July 2010 and lasting ~20 days. The uncertainty in >30 keV precipitation flux determined by the AARDDVARK technique was found to be ±10%. Peak >30 keV precipitation fluxes of AARDDVARK-derived precipitation flux during the main and recovery phase of the largest geomagnetic storm, which started on 4 August 2010, were >105 el cm-2 s-1 sr-1. The largest fluxes observed by AARDDVARK occurred on the dayside and were delayed by several days from the start of the geomagnetic disturbance. During the main phase of the disturbances, nightside fluxes were dominant. Significant differences in flux estimates between POES, AARDDVARK, and the riometer were found after the main phase of the largest disturbance, with evidence provided to suggest that >700 keV electron precipitation was occurring. Currently the presence of such relativistic electron precipitation introduces some uncertainty in the analysis of AARDDVARK data, given the assumption of a power law electron precipitation spectrum.

  4. Fermi-LAT and Suzaku Observations of the Radio Galaxy Centaurus B

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Katsuta, Junichiro; /Stanford U., HEPL /KIPAC, Menlo Park; Tanaka, Y.T.

    2012-08-17

    CentaurusB is a nearby radio galaxy positioned in the Southern hemisphere close to the Galactic plane. Here we present a detailed analysis of about 43 months accumulation of Fermi-LAT data and of newly acquired Suzaku X-ray data for Centaurus B. The source is detected at GeV photon energies, although we cannot completely exclude the possibility that it is an artifact due to incorrect modeling of the bright Galactic diffuse emission in the region. The LAT image provides a weak hint of a spatial extension of the {gamma} rays along the radio lobes, which is consistent with the lack of sourcemore » variability in the GeV range. We note that the extension cannot be established statistically due to the low number of the photons. Surprisingly, we do not detect any diffuse emission of the lobes at X-ray frequencies, with the provided upper limit only marginally consistent with the previously claimed ASCA flux. The broad-band modeling shows that the observed {gamma}-ray flux of the source may be produced within the lobes, if the diffuse non-thermal X-ray emission component is not significantly below the derived Suzaku upper limit. This association would imply that efficient in-situ acceleration of the ultrarelativistic particles is occurring and that the lobes are dominated by the pressure from the relativistic particles. However, if the diffuse X-ray emission is much below the Suzaku upper limits, the observed {gamma}-ray flux is not likely to be produced within the lobes, but instead within the unresolved core of Centaurus B. In this case, the extended lobes could be dominated by the pressure of the magnetic field.« less

  5. Rapid gamma-ray flux variability during the 2013 March Crab Nebula flare

    DOE PAGES

    Mayer, Michael; Buehler, Rolf; Hays, Elizabeth; ...

    2013-09-11

    Here, we report on a bright flare in the Crab Nebula detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. The period of significantly increased luminosity occurred in 2013 March and lasted for approximately two weeks. During this period, we observed flux variability on timescales of approximately 5 hr. The combined photon flux above 100 MeV from the pulsar and its nebula reached a peak value of (12.5 ± 0.8) • 10 –6 cm –2 s –1 on 2013 March 6. This value exceeds the average flux by almost a factor of six and impliesmore » a ~20 times higher flux for the synchrotron component of the nebula alone. This is the second brightest flare observed from this source. Spectral and temporal analysis of the LAT data collected during the outburst reveal a rapidly varying synchrotron component of the Crab Nebula while the pulsar emission remains constant in time.« less

  6. Detection of the Small Magellanic Cloud in gamma-rays with  Fermi /LAT

    DOE PAGES

    Abdo, A. A.

    2010-11-01

    Context. The flux of gamma rays with energies greater than 100 MeV is dominated by diffuse emission coming from cosmic-rays (CRs) illuminating the interstellar medium (ISM) of our Galaxy through the processes of Bremsstrahlung, pion production and decay, and inverse-Compton scattering. The study of this diffuse emission provides insight into the origin and transport of cosmic rays. Aims. We searched for gamma-ray emission from the Small Magellanic Cloud (SMC) in order to derive constraints on the cosmic-ray population and transport in an external system with properties different from the Milky Way. Methods. We analysed the first 17 months of continuousmore » all-sky observations by the Large Area Telescope (LAT) of the Fermi mission to determine the spatial distribution, flux and spectrum of the gamma-ray emission from the SMC. We also used past radio synchrotron observations of the SMC to study the population of CR electrons specifically. Results. We obtained the first detection of the SMC in high-energy gamma rays, with an integrated >100 MeV flux of (3.7 ± 0.7) × 10 -8 ph cm -2 s -1, with additional systematic uncertainty of ≤16%. The emission is steady and from an extended source ~3° in size. It is not clearly correlated with the distribution of massive stars or neutral gas, nor with known pulsars or supernova remnants, but a certain correlation with supergiant shells is observed. Conclusions. The observed flux implies an upper limit on the average CR nuclei density in the SMC of ~15% of the value measured locally in the Milky Way. The population of high-energy pulsars of the SMC may account for a substantial fraction of the gamma-ray flux, which would make the inferred CR nuclei density even lower. The average density of CR electrons derived from radio synchrotron observations is consistent with the same reduction factor but the uncertainties are large. From our current knowledge of the SMC, such a low CR density does not seem to be due to a lower rate

  7. Fermi/LAT observations of lobe-dominant radio galaxy 3C 207 and possible radiation region of γ-rays

    NASA Astrophysics Data System (ADS)

    Guo, Sheng-Chu; Zhang, Hai-Ming; Zhang, Jin; Liang, En-Wei

    2018-06-01

    3C 207 is a lobe-dominant radio galaxy with a one sided jet and bright knots, spanning a kpc-Mpc scale, which have been resolved in the radio, optical and X-ray bands. This target was confirmed as a γ-ray emitter with Fermi/LAT, but it is uncertain whether the γ-ray emission region is the core or knots due to the low spatial resolution of Fermi/LAT. We present an analysis of its Fermi/LAT data acquired during the past 9 years. Different from the radio and optical emission from the core, it is found that the γ-ray emission is steady without detection of flux variation at over a 2σ confidence level. This likely implies that the γ-ray emission is from its knots. We collect the radio, optical and X-ray data of knot-A, the closest knot from the core at 1.4″, and compile its spectral energy distribution (SED). Although the single-zone synchrotron+SSC+IC/CMB model that assumes knot-A is at rest can reproduce the SED in the radio-optical-X-ray band, the predicted γ-ray flux is lower than the LAT observations and the derived magnetic field strength deviates from the equipartition condition by 3 orders of magnitude. Assuming that knot-A is moving relativistically, its SED from radio to γ-ray bands would be represented well with the single-zone synchrotron+SSC+IC/CMB model under the equipartition condition. These results likely suggest that the γ-ray emission may be from knot-A via the IC/CMB process and the knot should have relativistical motion. The jet power derived from our model parameters is also roughly consistent with the kinetic power estimated with radio data.

  8. Fermi-LAT detection of increased gamma-ray activity from the FSRQ PKS 1004-217

    NASA Astrophysics Data System (ADS)

    Kreter, Michael

    2018-03-01

    The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed an increasing gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar (FSRQ) PKS 1004-217 (3FGL J1006.7-2159) with coordinates RA: 10h06m46.4136s, DEC: -21d59m20.410s, J2000 (Beasley et al. 2002, ApJS, 141, 13) and redshift z=0.331 (Hewitt & Burbidge 1989, ApJS, 69, 1). Preliminary analysis indicates that on 4 March 2018, this source was in a high-flux state with a daily averaged gamma-ray flux (E > 100MeV) of (0.84+/-0.08) X 10^-6 photons cm^-2 s^-1 (statistical uncertainties only).

  9. Nightside electron flux measurements at Mars by the Phobos-2 HARP instrument

    NASA Technical Reports Server (NTRS)

    Shutte, N.; Gringauz, K.; Kiraly, P.; Kotova, G.; Nagy, A. F.; Rosenbauer, H.; Szego, K.; Verigin, M.

    1995-01-01

    All the available nightside electron data obtained during circular orbits at Mars from the Phobos-2 Hyperbolic Retarded Potential Analyzer (HARP) instrument have been examined in detail and are summarized in this paper. An electron flux component with energies exceeding that of the unperturbed solar wind was observed inside the magnetosheath, indicating the presence of acceleration mechanism(s). The character of the electron fluxes measured in the magnetotail cannot be classified in any simple manner, however, there is a correlation between the electron fluxes measured well inside this region and the unperturbed solar wind ram pressure.

  10. THE FIRST FERMI LAT SUPERNOVA REMNANT CATALOG

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Acero, F.; Ballet, J.; Ackermann, M.

    2016-05-01

    To uniformly determine the properties of supernova remnants (SNRs) at high energies, we have developed the first systematic survey at energies from 1 to 100 GeV using data from the Fermi Large Area Telescope (LAT). Based on the spatial overlap of sources detected at GeV energies with SNRs known from radio surveys, we classify 30 sources as likely GeV SNRs. We also report 14 marginal associations and 245 flux upper limits. A mock catalog in which the positions of known remnants are scrambled in Galactic longitude allows us to determine an upper limit of 22% on the number of GeV candidates falsely identifiedmore » as SNRs. We have also developed a method to estimate spectral and spatial systematic errors arising from the diffuse interstellar emission model, a key component of all Galactic Fermi LAT analyses. By studying remnants uniformly in aggregate, we measure the GeV properties common to these objects and provide a crucial context for the detailed modeling of individual SNRs. Combining our GeV results with multiwavelength (MW) data, including radio, X-ray, and TeV, we demonstrate the need for improvements to previously sufficient, simple models describing the GeV and radio emission from these objects. We model the GeV and MW emission from SNRs in aggregate to constrain their maximal contribution to observed Galactic cosmic rays.« less

  11. Fermi LAT detection of increased gamma-ray activity from the blazar TXS 1318+225

    NASA Astrophysics Data System (ADS)

    Torresi, E.; D'Ammando, F.; Tanaka, Y.

    2012-11-01

    The Large Area Telescope (LAT) onboard the Fermi Gamma-ray Space Telescope, has observed an increase in the gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar TXS 1318+225 (z=0.943, Sowards-Emmerd et al. 2003, ApJ, 590, 109; RA=200.2966771 deg, Dec=22.2700300 deg, J2000), also known as 2FGL J1321.1+2215 (Nolan et al. 2012, ApJS, 199, 31).

  12. Searches for correlation between UHECR events and high-energy gamma-ray Fermi-LAT data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Álvarez, Ezequiel; Cuoco, Alessandro; Mirabal, Nestor

    The astrophysical sources responsible for ultra high-energy cosmic rays (UHECRs) continue to be one of the most intriguing mysteries in astrophysics. We present a comprehensive search for correlations between high-energy (∼> 1 GeV) gamma-ray events from the Fermi Large Area Telescope (LAT) and UHECRs (∼> 60 EeV) detected by the Telescope Array and the Pierre Auger Observatory. We perform two separate searches. First, we conduct a standard cross-correlation analysis between the arrival directions of 148 UHECRs and 360 gamma-ray sources in the Second Catalog of Hard Fermi-LAT sources (2FHL). Second, we search for a possible correlation between UHECR directions andmore » unresolved Fermi -LAT gamma-ray emission. For the latter, we use three different methods: a stacking technique with both a model-dependent and model-independent background estimate, and a cross-correlation function analysis. We also test for statistically significant excesses in gamma rays from signal regions centered on Cen A and the Telescope Array hotspot. No significant correlation is found in any of the analyses performed, except a weak (∼< 2σ) hint of signal with the correlation function method on scales ∼ 1°. Upper limits on the flux of possible power-law gamma-ray sources of UHECRs are derived.« less

  13. SUZAKU X-RAY IMAGING OF THE EXTENDED LOBE IN THE GIANT RADIO GALAXY NGC 6251 ASSOCIATED WITH THE FERMI-LAT SOURCE 2FGL J1629.4+8236

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Takeuchi, Y.; Kataoka, J.; Takahashi, Y.

    2012-04-10

    We report the results of a Suzaku X-ray imaging study of NGC 6251, a nearby giant radio galaxy with intermediate FR I/II radio properties. Our pointing direction was centered on the {gamma}-ray emission peak recently discovered with the Fermi Large Area Telescope (LAT) around the position of the northwest (NW) radio lobe 15 arcmin offset from the nucleus. After subtracting two 'off-source' pointings adjacent to the radio lobe and removing possible contaminants in the X-ray Imaging Spectrometer field of view, we found significant residual X-ray emission most likely diffuse in nature. The spectrum of the excess X-ray emission is wellmore » fitted by a power law with a photon index {Gamma} = 1.90 {+-} 0.15 and a 0.5-8 keV flux of 4 Multiplication-Sign 10{sup -13} erg cm{sup -2} s{sup -1}. We interpret this diffuse X-ray emission component as being due to inverse Compton upscattering of the cosmic microwave background photons by ultrarelativistic electrons within the lobe, with only a minor contribution from the beamed emission of the large-scale jet. Utilizing archival radio data for the source, we demonstrate by means of broadband spectral modeling that the {gamma}-ray flux of the Fermi-LAT source 2FGL J1629.4+8236 may well be accounted for by the high-energy tail of the inverse Compton continuum of the lobe. Thus, this claimed association of {gamma}-rays from the NW lobe of NGC 6251, together with the recent Fermi-LAT imaging of the extended lobes of Centaurus A, indicates that particles may be efficiently (re-)accelerated up to ultrarelativistic energies within extended radio lobes of nearby radio galaxies in general.« less

  14. Characterizing Relativistic Electrons Flux Enhancement Events using sensors onboard SAMPEX and POLAR

    NASA Astrophysics Data System (ADS)

    Kanekal, S. G.; Selesnick, R. S.; Baker, D. N.; Blake, J. B.

    2004-12-01

    Relativistic electron fluxes in the Earth's outer Van Allen belt are highly variable with flux enhancements of several orders of magnitude occurring on time scales of a few days. Radiation belt electrons often are energized to relativistic energies when the magnetosphere is subjected to high solar wind speed and the southward turning of the interplanetary magnetic field. Characterization of electron acceleration properties such as electron spectra and flux isotropization are important in understanding acceleration models. We use sensors onboard SAMPEX and POLAR to measure and survey systematically these properties. SAMPEX measurements cover the entire outer zone for more than a decade from mid 1992 to mid 2004 and POLAR covers the time period from mid 1996 to the present. We use the pulse height analyzed data from the PET detector onboard SAMPEX to measure electron spectra. Fluxes measured by the HIST detector onboard POLAR together with the PET measurements are used to characterize isotropization times. This paper presents electron spectra and isotropization time scales for a few representative events. We will eventually extend these measurements and survey the entire solar cycle 23.

  15. Why do intimate partners live apart? Evidence on LAT relationships across Europe

    PubMed Central

    Liefbroer, Aart C.; Poortman, Anne-Rigt; Seltzer, Judith A.

    2015-01-01

    BACKGROUND Most research asks whether or not cohabitation has come to rival marriage. Little is known about the meaning of living apart together (LAT) relationships, and whether LAT is an alternative to marriage and cohabitation or a dating relationship. OBJECTIVE We examine across Europe: (1) the prevalence of LAT, (2) the reasons for LAT, and (3) the correlates of (a) LAT relationships vis-à-vis being single, married, or cohabiting, and (b) different types of LAT union. METHODS Using Generations and Gender Survey data from ten Western and Eastern European countries, we present descriptive statistics about LATs and estimate multinominal logistic regression models to assess the correlates of being in different types of LAT unions. RESULTS LAT relationships are uncommon, but they are more common in Western than Eastern Europe. Most people in LAT unions intend to live together but are apart for practical reasons. LAT is more common among young people, those enrolled in higher education, people with liberal attitudes, highly educated people, and those who have previously cohabited or been married. Older people and divorced or widowed persons are more likely to choose LAT to maintain independence. Surprisingly, attitudinal and educational differences are more pronounced in Eastern Europe than in Western Europe. CONCLUSIONS A tentative conclusion is that LAT is more often a stage in the union formation process than an alternative to marriage and cohabitation. Yet some groups do view LAT as substituting for marriage and cohabitation, and these groups differ between East and West. In Eastern Europe a cultural, highly educated elite seems to be the first to resist traditional marriage norms and embrace LAT (and cohabitation) as alternative living arrangements, whereas this is less the case in Western Europe. In Western Europe, LAT unions are mainly an alternative for persons who have been married before or had children in a prior relationship. PMID:26085812

  16. Laser-assisted tympanostomy (LAT) in adult individuals

    NASA Astrophysics Data System (ADS)

    Prokopakis, E. P.; Lachanas, V. A.; Helidonis, Emmanuel S.; Velegrakis, G.

    2004-06-01

    Objectives: To assess outcome, in adult individuals undergone Laser Assisted Tympanostomy (LAT) without ventilation tube placement. Method: LAT was performed on a total of 95 ears (72 individuals). Indications included serous otitis media with effusion (44 ears/31 patients), eustachian tube dysfunction (32 ears/24 patients), acute otitis media (13 ears/11 patients), and endoscopic visualization of the middle ear (6 ears/6 patients). Results: Middle ear disease was resolved after the closure of tympanostomy in 48% of patients with serous otitis media with effusion. In 78% of patients with Eustachian tube dysfunction symptoms were diminished. All patients with acute otitis media had a satisfactory outcome. LAT was found quite effective in patients undergoing middle ear endoscopy. Conclusion: LAT without ventilation tubes provides a safe alternative surgical option in adult patients in certain cases. The selection criteria for this procedure are addressed in detail.

  17. Fermi LAT detection of a GeV flare from the FSRQ PKS 1004-217

    NASA Astrophysics Data System (ADS)

    Valverde, Janeth; Ojha, Roopesh

    2017-11-01

    The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed an increasing gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar (FSRQ) PKS 1004-217 with coordinates RA: 10h06m46.4136s, DEC: -21d59m20.410s, J2000 (Beasley et al. 2002, ApJS, 141, 13) and redshift z=0.330 (Browne & Savage, 1977, MNRAS, 179, 65). Preliminary analysis indicates that on 8 November 2017 and 9 November 2017, this source was in a high-flux state with a daily averaged gamma-ray flux (E > 100MeV) of (0.5+/-0.1) X 10^-6 photons cm^-2 s^-1 and (0.5+/-0.1) X 10^-6 photons cm^-2 s^-1, respectively (statistical uncertainties only).

  18. The association of spacecraft anomalies with electron/proton particle fluxes at different orbits

    NASA Astrophysics Data System (ADS)

    Yi, K.; Moon, Y. J.

    2016-12-01

    In this study, we investigate 195 satellite anomaly data from 1998 to 2010 from Satellite News Digest (SND) to understand the association between spacecraft anomaly and space weather condition. The spacecraft anomalies are classified into Attitude & Propulsion, Power, Control, Telemetry, Instrument and unknown. For the investigation we divide these data according to the spacecraft orbit and launched year. Spacecraft's orbits are classified into the following two groups : (1) high altitude and low inclination, and (2) low altitude and high inclination. Launched year of spacecraft are divided into two groups: 1991 1998 and 1999 2007. We examine the association between these anomaly data and daily peak particle (electron and proton) flux data from GOES as well as their occurrence rates. To determine the association, we use two criteria that electron criterion is >10,000 pfu and proton criterion is >100 pfu. Main results from this study are as follows. First, the number of days satisfying the criteria for electron flux has a peak near a week before the anomaly day and decreases from the peak day to the anomaly day, while that for proton flux has a peak near the anomaly day. Second, we found a similar pattern for the mean daily peak particle (electron and proton) flux as a function of day before the anomaly day. Third, an examination of multiple spacecraft anomaly events, which are likely to occur by severe space weather effects, shows that anomalies mostly occur either when electron fluxes are in the declining stage, or when daily proton peak fluxes are strongly enhanced. Fourth, the time delay between the anomaly day and the day having the highest daily peak electron flux for the recent launching period (1999-2007) is noticeably larger than those for the older periods, implying that the anomaly characteristics associated with electron flux change with time.

  19. RAPID GAMMA-RAY FLUX VARIABILITY DURING THE 2013 MARCH CRAB NEBULA FLARE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mayer, M.; Buehler, R.; Hays, E.

    2013-10-01

    We report on a bright flare in the Crab Nebula detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. The period of significantly increased luminosity occurred in 2013 March and lasted for approximately two weeks. During this period, we observed flux variability on timescales of approximately 5 hr. The combined photon flux above 100 MeV from the pulsar and its nebula reached a peak value of (12.5 ± 0.8) · 10{sup –6} cm{sup –2} s{sup –1} on 2013 March 6. This value exceeds the average flux by almost a factor of six and implies amore » ∼20 times higher flux for the synchrotron component of the nebula alone. This is the second brightest flare observed from this source. Spectral and temporal analysis of the LAT data collected during the outburst reveal a rapidly varying synchrotron component of the Crab Nebula while the pulsar emission remains constant in time.« less

  20. Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells: LAT1 is a promising molecular target for human cancer therapy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ohkawa, Mayumi; Ohno, Yoshiya; Masuko, Kazue

    Highlights: {yields} We established LAT1 amino-acid transporter-disrupted DT40 cells. {yields} LAT1-disrupted cells showed slow growth and lost the oncogenicity. {yields} siRNA and mAb inhibited human tumor growth in vitro and in vivo. {yields} LAT1 is a promising target molecule for cancer therapy. -- Abstract: L-type amino-acid transporter 1 (LAT1) is the first identified light chain of CD98 molecule, disulfide-linked to a heavy chain of CD98. Following cDNA cloning of chicken full-length LAT1, we have constructed targeting vectors for the disruption of chicken LAT1 gene from genomic DNA of chicken LAT1 consisting of 5.4 kb. We established five homozygous LAT1-disrupted (LAT1{supmore » -/-}) cell clones, derived from a heterozygous LAT1{sup +/-} clone of DT40 chicken B cell line. Reactivity of anti-chicken CD98hc monoclonal antibody (mAb) with LAT1{sup -/-} DT40 cells was markedly decreased compared with that of wild-type DT40 cells. All LAT1{sup -/-} cells were deficient in L-type amino-acid transporting activity, although alternative-splice variant but not full-length mRNA of LAT1 was detected in these cells. LAT1{sup -/-} DT40 clones showed outstandingly slow growth in liquid culture and decreased colony-formation capacity in soft agar compared with wild-type DT40 cells. Cell-cycle analyses indicated that LAT1{sup -/-} DT40 clones have prolonged cell-cycle phases compared with wild-type or LAT1{sup +/-} DT40 cells. Knockdown of human LAT1 by small interfering RNAs resulted in marked in vitro cell-growth inhibition of human cancer cells, and in vivo tumor growth of HeLa cells in athymic mice was significantly inhibited by anti-human LAT1 mAb. All these results indicate essential roles of LAT1 in the cell proliferation and occurrence of malignant phenotypes and that LAT1 is a promising candidate as a molecular target of human cancer therapy.« less

  1. Quantitative comparisons of type 3 radio burst intensity and fast electron flux at 1 AU

    NASA Technical Reports Server (NTRS)

    Fitzenreiter, R. J.; Evans, L. G.; Lin, R. P.

    1975-01-01

    The flux of fast solar electrons and the intensity of the type 111 radio emission generated by these particles were compared at one AU. Two regimes were found in the generation of type 111 radiation: one where the radio intensity is linearly proportional to the electron flux, and another, which occurs above a threshold electron flux, where the radio intensity is approximately proportional to the 2.4 power of the electron flux. This threshold appears to reflect a transition to a different emission mechanism.

  2. Prediction of MeV electron fluxes throughout the outer radiation belt using multivariate autoregressive models

    NASA Astrophysics Data System (ADS)

    Sakaguchi, Kaori; Nagatsuma, Tsutomu; Reeves, Geoffrey D.; Spence, Harlan E.

    2015-12-01

    The Van Allen radiation belts surrounding the Earth are filled with MeV-energy electrons. This region poses ionizing radiation risks for spacecraft that operate within it, including those in geostationary orbit (GEO) and medium Earth orbit. To provide alerts of electron flux enhancements, 16 prediction models of the electron log-flux variation throughout the equatorial outer radiation belt as a function of the McIlwain L parameter were developed using the multivariate autoregressive model and Kalman filter. Measurements of omnidirectional 2.3 MeV electron flux from the Van Allen Probes mission as well as >2 MeV electrons from the GOES 15 spacecraft were used as the predictors. Model explanatory parameters were selected from solar wind parameters, the electron log-flux at GEO, and geomagnetic indices. For the innermost region of the outer radiation belt, the electron flux is best predicted by using the Dst index as the sole input parameter. For the central to outermost regions, at L ≧ 4.8 and L ≧ 5.6, the electron flux is predicted most accurately by including also the solar wind velocity and then the dynamic pressure, respectively. The Dst index is the best overall single parameter for predicting at 3 ≦ L ≦ 6, while for the GEO flux prediction, the KP index is better than Dst. A test calculation demonstrates that the model successfully predicts the timing and location of the flux maximum as much as 2 days in advance and that the electron flux decreases faster with time at higher L values, both model features consistent with the actually observed behavior.

  3. Prediction of MeV electron fluxes throughout the outer radiation belt using multivariate autoregressive models

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sakaguchi, Kaori; Nagatsuma, Tsutomu; Reeves, Geoffrey D.

    The Van Allen radiation belts surrounding the Earth are filled with MeV-energy electrons. This region poses ionizing radiation risks for spacecraft that operate within it, including those in geostationary orbit (GEO) and medium Earth orbit. In order to provide alerts of electron flux enhancements, 16 prediction models of the electron log-flux variation throughout the equatorial outer radiation belt as a function of the McIlwain L parameter were developed using the multivariate autoregressive model and Kalman filter. Measurements of omnidirectional 2.3 MeV electron flux from the Van Allen Probes mission as well as >2 MeV electrons from the GOES 15 spacecraftmore » were used as the predictors. Furthermore, we selected model explanatory parameters from solar wind parameters, the electron log-flux at GEO, and geomagnetic indices. For the innermost region of the outer radiation belt, the electron flux is best predicted by using the Dst index as the sole input parameter. For the central to outermost regions, at L≥4.8 and L ≥5.6, the electron flux is predicted most accurately by including also the solar wind velocity and then the dynamic pressure, respectively. The Dst index is the best overall single parameter for predicting at 3 ≤ L ≤ 6, while for the GEO flux prediction, the K P index is better than Dst. Finally, a test calculation demonstrates that the model successfully predicts the timing and location of the flux maximum as much as 2 days in advance and that the electron flux decreases faster with time at higher L values, both model features consistent with the actually observed behavior.« less

  4. Prediction of MeV electron fluxes throughout the outer radiation belt using multivariate autoregressive models

    DOE PAGES

    Sakaguchi, Kaori; Nagatsuma, Tsutomu; Reeves, Geoffrey D.; ...

    2015-12-22

    The Van Allen radiation belts surrounding the Earth are filled with MeV-energy electrons. This region poses ionizing radiation risks for spacecraft that operate within it, including those in geostationary orbit (GEO) and medium Earth orbit. In order to provide alerts of electron flux enhancements, 16 prediction models of the electron log-flux variation throughout the equatorial outer radiation belt as a function of the McIlwain L parameter were developed using the multivariate autoregressive model and Kalman filter. Measurements of omnidirectional 2.3 MeV electron flux from the Van Allen Probes mission as well as >2 MeV electrons from the GOES 15 spacecraftmore » were used as the predictors. Furthermore, we selected model explanatory parameters from solar wind parameters, the electron log-flux at GEO, and geomagnetic indices. For the innermost region of the outer radiation belt, the electron flux is best predicted by using the Dst index as the sole input parameter. For the central to outermost regions, at L≥4.8 and L ≥5.6, the electron flux is predicted most accurately by including also the solar wind velocity and then the dynamic pressure, respectively. The Dst index is the best overall single parameter for predicting at 3 ≤ L ≤ 6, while for the GEO flux prediction, the K P index is better than Dst. Finally, a test calculation demonstrates that the model successfully predicts the timing and location of the flux maximum as much as 2 days in advance and that the electron flux decreases faster with time at higher L values, both model features consistent with the actually observed behavior.« less

  5. Fermi -LAT Observations of High-energy Behind-the-limb Solar Flares

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ackermann, M.; Buehler, R.; Allafort, A.

    2017-02-01

    We report on the Fermi -LAT detection of high-energy emission from the behind-the-limb (BTL) solar flares that occurred on 2013 October 11, and 2014 January 6 and September 1. The Fermi -LAT observations are associated with flares from active regions originating behind both the eastern and western limbs, as determined by STEREO . All three flares are associated with very fast coronal mass ejections (CMEs) and strong solar energetic particle events. We present updated localizations of the >100 MeV photon emission, hard X-ray (HXR) and EUV images, and broadband spectra from 10 keV to 10 GeV, as well as microwavemore » spectra. We also provide a comparison of the BTL flares detected by Fermi -LAT with three on-disk flares and present a study of some of the significant quantities of these flares as an attempt to better understand the acceleration mechanisms at work during these occulted flares. We interpret the HXR emission to be due to electron bremsstrahlung from a coronal thin-target loop top with the accelerated electron spectra steepening at semirelativistic energies. The >100 MeV gamma-rays are best described by a pion-decay model resulting from the interaction of protons (and other ions) in a thick-target photospheric source. The protons are believed to have been accelerated (to energies >10 GeV) in the CME environment and precipitate down to the photosphere from the downstream side of the CME shock and landed on the front side of the Sun, away from the original flare site and the HXR emission.« less

  6. Fermi-LAT Observations of High-energy Behind-the-limb Solar Flares

    DOE PAGES

    Ackermann, M.; Allafort, A.; Baldini, L.; ...

    2017-01-31

    In this paper, we report on the Fermi-LAT detection of high-energy emission from the behind-the-limb (BTL) solar flares that occurred on 2013 October 11, and 2014 January 6 and September 1. The Fermi-LAT observations are associated with flares from active regions originating behind both the eastern and western limbs, as determined by STEREO. All three flares are associated with very fast coronal mass ejections (CMEs) and strong solar energetic particle events. We present updated localizations of the >100 MeV photon emission, hard X-ray (HXR) and EUV images, and broadband spectra from 10 keV to 10 GeV, as well as microwavemore » spectra. We also provide a comparison of the BTL flares detected by Fermi-LAT with three on-disk flares and present a study of some of the significant quantities of these flares as an attempt to better understand the acceleration mechanisms at work during these occulted flares. We interpret the HXR emission to be due to electron bremsstrahlung from a coronal thin-target loop top with the accelerated electron spectra steepening at semirelativistic energies. The >100 MeV gamma-rays are best described by a pion-decay model resulting from the interaction of protons (and other ions) in a thick-target photospheric source. In conclusion, the protons are believed to have been accelerated (to energies >10 GeV) in the CME environment and precipitate down to the photosphere from the downstream side of the CME shock and landed on the front side of the Sun, away from the original flare site and the HXR emission.« less

  7. Searches for correlation between UHECR events and high-energy gamma-ray Fermi-LAT data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Álvarez, Ezequiel; Cuoco, Alessandro; Mirabal, Nestor

    The astrophysical sources responsible for ultra high-energy cosmic rays (UHECRs) continue to be one of the most intriguing mysteries in astrophysics. Here, we present a comprehensive search for correlations between high-energy (≳ 1 GeV) gamma-ray events from the Fermi Large Area Telescope (LAT) and UHECRs (≳ 60 EeV) detected by the Telescope Array and the Pierre Auger Observatory. We perform two separate searches. First, we conduct a standard cross-correlation analysis between the arrival directions of 148 UHECRs and 360 gamma-ray sources in the Second Catalog of Hard Fermi-LAT sources (2FHL). Second, we search for a possible correlation between UHECR directionsmore » and unresolved Fermi-LAT gamma-ray emission. For the latter, we use three different methods: a stacking technique with both a model-dependent and model-independent background estimate, and a cross-correlation function analysis. We also test for statistically significant excesses in gamma rays from signal regions centered on Cen A and the Telescope Array hotspot. There was no significant correlation is found in any of the analyses performed, except a weak (≲ 2σ) hint of signal with the correlation function method on scales ~ 1°. Upper limits on the flux of possible power-law gamma-ray sources of UHECRs are derived.« less

  8. Searches for correlation between UHECR events and high-energy gamma-ray Fermi-LAT data

    DOE PAGES

    Álvarez, Ezequiel; Cuoco, Alessandro; Mirabal, Nestor; ...

    2016-12-13

    The astrophysical sources responsible for ultra high-energy cosmic rays (UHECRs) continue to be one of the most intriguing mysteries in astrophysics. Here, we present a comprehensive search for correlations between high-energy (≳ 1 GeV) gamma-ray events from the Fermi Large Area Telescope (LAT) and UHECRs (≳ 60 EeV) detected by the Telescope Array and the Pierre Auger Observatory. We perform two separate searches. First, we conduct a standard cross-correlation analysis between the arrival directions of 148 UHECRs and 360 gamma-ray sources in the Second Catalog of Hard Fermi-LAT sources (2FHL). Second, we search for a possible correlation between UHECR directionsmore » and unresolved Fermi-LAT gamma-ray emission. For the latter, we use three different methods: a stacking technique with both a model-dependent and model-independent background estimate, and a cross-correlation function analysis. We also test for statistically significant excesses in gamma rays from signal regions centered on Cen A and the Telescope Array hotspot. There was no significant correlation is found in any of the analyses performed, except a weak (≲ 2σ) hint of signal with the correlation function method on scales ~ 1°. Upper limits on the flux of possible power-law gamma-ray sources of UHECRs are derived.« less

  9. FLaapLUC: A pipeline for the generation of prompt alerts on transient Fermi-LAT γ-ray sources

    NASA Astrophysics Data System (ADS)

    Lenain, J.-P.

    2018-01-01

    The large majority of high energy sources detected with Fermi-LAT are blazars, which are known to be very variable sources. High cadence long-term monitoring simultaneously at different wavelengths being prohibitive, the study of their transient activities can help shedding light on our understanding of these objects. The early detection of such potentially fast transient events is the key for triggering follow-up observations at other wavelengths. A Python tool, FLaapLUC, built on top of the Science Tools provided by the Fermi Science Support Center and the Fermi-LAT collaboration, has been developed using a simple aperture photometry approach. This tool can effectively detect relative flux variations in a set of predefined sources and alert potential users. Such alerts can then be used to trigger target of opportunity observations with other facilities. It is shown that FLaapLUC is an efficient tool to reveal transient events in Fermi-LAT data, providing quick results which can be used to promptly organise follow-up observations. Results from this simple aperture photometry method are also compared to full likelihood analyses. The FLaapLUC package is made available on GitHub and is open to contributions by the community.

  10. The role of electron heat flux in guide-field magnetic reconnection

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hesse, Michael; Kuznetsova, Masha; Birn, Joachim

    2004-12-01

    A combination of analytical theory and particle-in-cell simulations are employed in order to investigate the electron dynamics near and at the site of guide field magnetic reconnection. A detailed analysis of the contributions to the reconnection electric field shows that both bulk inertia and pressure-based quasiviscous processes are important for the electrons. Analytic scaling demonstrates that conventional approximations for the electron pressure tensor behavior in the dissipation region fail, and that heat flux contributions need to be accounted for. Based on the evolution equation of the heat flux three tensor, which is derived in this paper, an approximate form ofmore » the relevant heat flux contributions to the pressure tensor is developed, which reproduces the numerical modeling result reasonably well. Based on this approximation, it is possible to develop a scaling of the electron current layer in the central dissipation region. It is shown that the pressure tensor contributions become important at the scale length defined by the electron Larmor radius in the guide magnetic field.« less

  11. Measurement of neutrino flux from neutrino-electron elastic scattering

    NASA Astrophysics Data System (ADS)

    Park, J.; Aliaga, L.; Altinok, O.; Bellantoni, L.; Bercellie, A.; Betancourt, M.; Bodek, A.; Bravar, A.; Budd, H.; Cai, T.; Carneiro, M. F.; Christy, M. E.; Chvojka, J.; da Motta, H.; Dytman, S. A.; Díaz, G. A.; Eberly, B.; Felix, J.; Fields, L.; Fine, R.; Gago, A. M.; Galindo, R.; Ghosh, A.; Golan, T.; Gran, R.; Harris, D. A.; Higuera, A.; Kleykamp, J.; Kordosky, M.; Le, T.; Maher, E.; Manly, S.; Mann, W. A.; Marshall, C. M.; Martinez Caicedo, D. A.; McFarland, K. S.; McGivern, C. L.; McGowan, A. M.; Messerly, B.; Miller, J.; Mislivec, A.; Morfín, J. G.; Mousseau, J.; Naples, D.; Nelson, J. K.; Norrick, A.; Nuruzzaman; Osta, J.; Paolone, V.; Patrick, C. E.; Perdue, G. N.; Rakotondravohitra, L.; Ramirez, M. A.; Ray, H.; Ren, L.; Rimal, D.; Rodrigues, P. A.; Ruterbories, D.; Schellman, H.; Solano Salinas, C. J.; Tagg, N.; Tice, B. G.; Valencia, E.; Walton, T.; Wolcott, J.; Wospakrik, M.; Zavala, G.; Zhang, D.; Miner ν A Collaboration

    2016-06-01

    Muon-neutrino elastic scattering on electrons is an observable neutrino process whose cross section is precisely known. Consequently a measurement of this process in an accelerator-based νμ beam can improve the knowledge of the absolute neutrino flux impinging upon the detector; typically this knowledge is limited to ˜10 % due to uncertainties in hadron production and focusing. We have isolated a sample of 135 ±17 neutrino-electron elastic scattering candidates in the segmented scintillator detector of MINERvA, after subtracting backgrounds and correcting for efficiency. We show how this sample can be used to reduce the total uncertainty on the NuMI νμ flux from 9% to 6%. Our measurement provides a flux constraint that is useful to other experiments using the NuMI beam, and this technique is applicable to future neutrino beams operating at multi-GeV energies.

  12. Quantitative comparisons of type III radio burst intensity and fast electron flux at 1 AU

    NASA Technical Reports Server (NTRS)

    Fitzenreiter, R. J.; Evans, L. G.; Lin, R. P.

    1976-01-01

    We compare the flux of fast solar electrons and the intensity of the type III radio emission generated by these particles at 1 AU. We find that there are two regimes in the generation of type III radiation: one where the radio intensity is linearly proportional to the electron flux, and the second regime, which occurs above a threshold electron flux, where the radio intensity is proportional to the approximately 2.4 power of the electron flux. This threshold appears to reflect a transition to a different emission mechanism.

  13. Simulation of high-energy radiation belt electron fluxes using NARMAX-VERB coupled codes

    PubMed Central

    Pakhotin, I P; Drozdov, A Y; Shprits, Y Y; Boynton, R J; Subbotin, D A; Balikhin, M A

    2014-01-01

    This study presents a fusion of data-driven and physics-driven methodologies of energetic electron flux forecasting in the outer radiation belt. Data-driven NARMAX (Nonlinear AutoRegressive Moving Averages with eXogenous inputs) model predictions for geosynchronous orbit fluxes have been used as an outer boundary condition to drive the physics-based Versatile Electron Radiation Belt (VERB) code, to simulate energetic electron fluxes in the outer radiation belt environment. The coupled system has been tested for three extended time periods totalling several weeks of observations. The time periods involved periods of quiet, moderate, and strong geomagnetic activity and captured a range of dynamics typical of the radiation belts. The model has successfully simulated energetic electron fluxes for various magnetospheric conditions. Physical mechanisms that may be responsible for the discrepancies between the model results and observations are discussed. PMID:26167432

  14. Revisiting simplified dark matter models in terms of AMS-02 and Fermi-LAT

    NASA Astrophysics Data System (ADS)

    Li, Tong

    2018-01-01

    We perform an analysis of the simplified dark matter models in the light of cosmic ray observables by AMS-02 and Fermi-LAT. We assume fermion, scalar or vector dark matter particle with a leptophobic spin-0 mediator that couples only to Standard Model quarks and dark matter via scalar and/or pseudo-scalar bilinear. The propagation and injection parameters of cosmic rays are determined by the observed fluxes of nuclei from AMS-02. We find that the AMS-02 observations are consistent with the dark matter framework within the uncertainties. The AMS-02 antiproton data prefer 30 (50) GeV - 5 TeV dark matter mass and require an effective annihilation cross section in the region of 4 × 10-27 (7 × 10-27) - 4 × 10-24 cm3/s for the simplified fermion (scalar and vector) dark matter models. The cross sections below 2 × 10-26 cm3/s can evade the constraint from Fermi-LAT dwarf galaxies for about 100 GeV dark matter mass.

  15. Fermi LAT Detection of a GeV Flare from FSRQ PKS 2320-035

    NASA Astrophysics Data System (ADS)

    Carpenter, Bryce; Ojha, Roopesh

    2013-04-01

    The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar PKS 2320-035 (also known as 2FGL J2323.6-0316, Nolan et al. 2012, ApJS, 199, 31). PKS 2320-035 has coordinates RA=23h23m31.9537s DEC=-03d17m05.023s, J2000, (Johnston et al. 1995, AJ, 110, 880) and redshift z=1.41 (Browne et al.

  16. Extreme relativistic electron fluxes at geosynchronous orbit: Analysis of GOES E > 2 MeV electrons

    NASA Astrophysics Data System (ADS)

    Meredith, Nigel P.; Horne, Richard B.; Isles, John D.; Rodriguez, Juan V.

    2015-03-01

    Relativistic electrons (E > 1 MeV) cause internal charging on satellites and are an important space weather hazard. A key requirement in space weather research concerns extreme events and knowledge of the largest flux expected to be encountered over the lifetime of a satellite mission. This is interesting both from scientific and practical points of view since satellite operators, engineers, and the insurance industry need this information to better evaluate the effects of extreme events on their spacecraft. Here we conduct an extreme value analysis of daily averaged E > 2 MeV electron fluxes from the Geostationary Operational Environmental Satellites (GOES) during the 19.5 year period from 1 January 1995 to 30 June 2014. We find that the daily averaged flux measured at GOES West is typically a factor of about 2.5 higher than that measured at GOES East, and we conduct independent analyses for these two locations. The 1 in 10, 1 in 50, and 1 in 100 year daily averaged E > 2 MeV electron fluxes at GOES West are 1.84 ×105, 5.00 ×105, and 7.68 ×105 cm-2 s-1 sr-1, respectively. The corresponding fluxes at GOES East are 6.53 ×104, 1.98 ×105, and 3.25 ×105 cm-2 s-1 sr-1, respectively. The largest fluxes seen during the 19.5 year period on 29 July 2004 were particularly extreme and were seen by satellites at GOES West and GOES East. The extreme value analysis suggests that this event was a 1 in 50 year event.

  17. HF Accelerated Electron Fluxes, Spectra, and Ionization

    NASA Astrophysics Data System (ADS)

    Carlson, Herbert C.; Jensen, Joseph B.

    2015-10-01

    Wave particle interactions, an essential aspect of laboratory, terrestrial, and astrophysical plasmas, have been studied for decades by transmitting high power HF radio waves into Earth's weakly ionized space plasma, to use it as a laboratory without walls. Application to HF electron acceleration remains an active area of research (Gurevich in Usp Fizicheskikh Nauk 177(11):1145-1177, 2007) today. HF electron acceleration studies began when plasma line observations proved (Carlson et al. in J Atmos Terr Phys 44:1089-1100, 1982) that high power HF radio wave-excited processes accelerated electrons not to ~eV, but instead to -100 times thermal energy (10 s of eV), as a consequence of inelastic collision effects on electron transport. Gurevich et al (J Atmos Terr Phys 47:1057-1070, 1985) quantified the theory of this transport effect. Merging experiment with theory in plasma physics and aeronomy, enabled prediction (Carlson in Adv Space Res 13:1015-1024, 1993) of creating artificial ionospheres once ~GW HF effective radiated power could be achieved. Eventual confirmation of this prediction (Pedersen et al. in Geophys Res Lett 36:L18107, 2009; Pedersen et al. in Geophys Res Lett 37:L02106, 2010; Blagoveshchenskaya et al. in Ann Geophys 27:131-145, 2009) sparked renewed interest in optical inversion to estimate electron spectra in terrestrial (Hysell et al. in J Geophys Res Space Phys 119:2038-2045, 2014) and planetary (Simon et al. in Ann Geophys 29:187-195, 2011) atmospheres. Here we present our unpublished optical data, which combined with our modeling, lead to conclusions that should meaningfully improve future estimates of the spectrum of HF accelerated electron fluxes. Photometric imaging data can significantly improve detection of emissions near ionization threshold, and confirm depth of penetration of accelerated electrons many km below the excitation altitude. Comparing observed to modeled emission altitude shows future experiments need electron density profiles

  18. Fermi LAT detection of renewed gamma-ray activity from the FSRQ PKS 2326-502

    NASA Astrophysics Data System (ADS)

    D'Ammando, F.; Torresi, E.

    2012-06-01

    The Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope has observed an increasing gamma-ray flux from a source positionally consistent with the Flat Spectrum Radio Quasar PKS 2326-502 (also known as 2FGL J2329.2-4956, Nolan et al. 2012, ApJS, 199, 31; R.A.=23:29:20.880 Dec.=-49:55:40.68, J2000.0, Costa and Loyola 1996, A&AS, 115, 75) at redshift z=0.518 (Jauncey et al. 1984, ApJ, 286, 498).

  19. Searching for high-energy gamma-ray counterparts to gravitational-wave sources with Fermi-LAT: A needle in a haystack

    DOE PAGES

    Vianello, G.; Omodei, N.; Chiang, J.; ...

    2017-05-20

    At least a fraction of gravitational-wave (GW) progenitors are expected to emit an electromagnetic (EM) signal in the form of a short gamma-ray burst (sGRB). Discovering such a transient EM counterpart is challenging because the LIGO/VIRGO localization region is much larger (several hundreds of square degrees) than the field of view of X-ray, optical, and radio telescopes. The Fermi Large Area Telescope (LAT) has a wide field of view (~2.4 sr) and detects ~2–3 sGRBs per year above 100 MeV. It can detect them not only during the short prompt phase, but also during their long-lasting high-energy afterglow phase. If other wide-field, high-energy instruments such as Fermi-GBM, Swift-BAT, or INTEGRAL-ISGRI cannot detect or localize with enough precision an EM counterpart during the prompt phase, the LAT can potentially pinpoint it withmore » $$\\lesssim 10$$ arcmin accuracy during the afterglow phase. This routinely happens with gamma-ray bursts. Moreover, the LAT will cover the entire localization region within hours of any triggers during normal operations, allowing the γ-ray flux of any EM counterpart to be measured or constrained. As a result, we illustrate two new ad hoc methods to search for EM counterparts with the LAT and their application to the GW candidate LVT151012.« less

  20. Searching for high-energy gamma-ray counterparts to gravitational-wave sources with Fermi-LAT: A needle in a haystack

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vianello, G.; Omodei, N.; Chiang, J.

    At least a fraction of gravitational-wave (GW) progenitors are expected to emit an electromagnetic (EM) signal in the form of a short gamma-ray burst (sGRB). Discovering such a transient EM counterpart is challenging because the LIGO/VIRGO localization region is much larger (several hundreds of square degrees) than the field of view of X-ray, optical, and radio telescopes. The Fermi Large Area Telescope (LAT) has a wide field of view (~2.4 sr) and detects ~2–3 sGRBs per year above 100 MeV. It can detect them not only during the short prompt phase, but also during their long-lasting high-energy afterglow phase. If other wide-field, high-energy instruments such as Fermi-GBM, Swift-BAT, or INTEGRAL-ISGRI cannot detect or localize with enough precision an EM counterpart during the prompt phase, the LAT can potentially pinpoint it withmore » $$\\lesssim 10$$ arcmin accuracy during the afterglow phase. This routinely happens with gamma-ray bursts. Moreover, the LAT will cover the entire localization region within hours of any triggers during normal operations, allowing the γ-ray flux of any EM counterpart to be measured or constrained. As a result, we illustrate two new ad hoc methods to search for EM counterparts with the LAT and their application to the GW candidate LVT151012.« less

  1. Fermi-LAT Gamma-ray Bursts and Insight from Swift

    NASA Technical Reports Server (NTRS)

    Racusin, Judith L.

    2011-01-01

    A new revolution in GRB observation and theory has begun over the last 3 years since the launch of the Fermi gamma-ray space telescope. The new window into high energy gamma-rays opened by the Fermi-LAT is providing insight into prompt emission mechanisms and possibly also afterglow physics. The LAT detected GRBs appear to be a new unique subset of extremely energetic and bright bursts. In this talk I will discuss the context and recent discoveries from these LAT GRBs and the large database of broadband observations collected by Swift over the last 7 years and how through comparisons between the Swift, GBM, and LAT GRB samples, we can learn about the unique characteristics and relationships between each population.

  2. The First FERMI-LAT Gamma-Ray Burst Catalog

    NASA Technical Reports Server (NTRS)

    Ackermann, M.; Ajello, M.; Asano, K.; Axelsson, M.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; hide

    2013-01-01

    In three years of observations since the beginning of nominal science operations in 2008 August, the Large Area Telescope (LAT) on board the Fermi Gamma-Ray Space Telescope has observed high-energy great than (20 MeV) gamma-ray emission from 35 gamma-ray bursts (GRBs). Among these, 28 GRBs have been detected above 100 MeV and 7 GRBs above approximately 20 MeV. The first Fermi-LAT catalog of GRBs is a compilation of these detections and provides a systematic study of high-energy emission from GRBs for the first time. To generate the catalog, we examined 733 GRBs detected by the Gamma-Ray Burst Monitor (GBM) on Fermi and processed each of them using the same analysis sequence. Details of the methodology followed by the LAT collaboration for the GRB analysis are provided. We summarize the temporal and spectral properties of the LAT-detected GRBs. We also discuss characteristics of LAT-detected emission such as its delayed onset and longer duration compared with emission detected by the GBM, its power-law temporal decay at late times, and the fact that it is dominated by a power-law spectral component that appears in addition to the usual Band model.

  3. The first Fermi-LAT Gamma-Ray burst catalog

    DOE PAGES

    Ackermann, M.; Ajello, M.; Asano, K.; ...

    2013-10-23

    In three years of observations since the beginning of nominal science operations in 2008 August, the Large Area Telescope (LAT) on board the Fermi Gamma-Ray Space Telescope has observed high-energy (gsim 20 MeV) γ-ray emission from 35 gamma-ray bursts (GRBs). Among these, 28 GRBs have been detected above 100 MeV and 7 GRBs above ~20 MeV. The first Fermi-LAT catalog of GRBs is a compilation of these detections and provides a systematic study of high-energy emission from GRBs for the first time. To generate the catalog, we examined 733 GRBs detected by the Gamma-Ray Burst Monitor (GBM) on Fermi andmore » processed each of them using the same analysis sequence. Details of the methodology followed by the LAT collaboration for the GRB analysis are provided. Here, we summarize the temporal and spectral properties of the LAT-detected GRBs. We also discuss characteristics of LAT-detected emission such as its delayed onset and longer duration compared with emission detected by the GBM, its power-law temporal decay at late times, and the fact that it is dominated by a power-law spectral component that appears in addition to the usual Band model.« less

  4. Quasiperiodic modulations of energetic electron fluxes in the ULF range observed by the ERG satellite

    NASA Astrophysics Data System (ADS)

    Teramoto, M.; Hori, T.; Kurita, S.; Yoshizumi, M.; Saito, S.; Higashio, N.; Mitani, T.; Matsuoka, A.; Park, I.; Takashima, T.; Nomura, R.; Nose, M.; Fujimoto, A.; Tanaka, Y.; Shinohara, M.; Shinohara, I.

    2017-12-01

    Exploration of energization and Radiation in Geospace (ERG) satellite was successfully launched on December 20, 2016. The Extremely High-Energy Electron Experiment (XEP) and High-Energy Electron Experiments (HEP-L and HEP-H) are carried by the ERG satellite to observe energetic electrons. These instruments frequently observed quasiperiodic modulations of energetic electron fluxes with period of 100-600 sec. Continuous flux modulations with the period of 600 s appeared in the 700keV-3.6MeV energy range during the period 0920UT-1120UT on March 31, 2017 when the ERG satellite was located at L 5.5-6.1 and MLT 3-4 h. We compare these flux modulations with the magnetic field observed by the Magnetic Field Experiment (MGF) on the ERG satellite. It is found that these flux modulations are not accompanied by corresponding magnetic signatures. It indicates that these quasiperiodic flux modulations are not caused by drift-resonant interactions between ULF waves and energetic electrons, at least locally. In this study, we will show several events and discuss possible mechanism for quasiperiodic flux modulations of energetic electrons on XEP and HEP.

  5. High flux, narrow bandwidth compton light sources via extended laser-electron interactions

    DOEpatents

    Barty, V P

    2015-01-13

    New configurations of lasers and electron beams efficiently and robustly produce high flux beams of bright, tunable, polarized quasi-monoenergetic x-rays and gamma-rays via laser-Compton scattering. Specifically, the use of long-duration, pulsed lasers and closely-spaced, low-charge and low emittance bunches of electron beams increase the spectral flux of the Compton-scattered x-rays and gamma rays, increase efficiency of the laser-electron interaction and significantly reduce the overall complexity of Compton based light sources.

  6. The missing GeV γ-ray binary: Searching for HESS J0632+057 with Fermi-LAT

    DOE PAGES

    Caliandro, G. A.; Hill, A. B.; Torres, D. F.; ...

    2013-09-25

    The very high energy (VHE; >100 GeV) source HESS J0632+057 has been recently confirmed as a γ-ray binary, a subclass of the high-mass X-ray binary population, through the detection of an orbital period of 321 d. We performed a deep search for the emission of HESS J0632+057 in the GeV energy range using data from the Fermi Large Area Telescope (LAT). The analysis was challenging due to the source being located in close proximity to the bright γ-ray pulsar PSR J0633+0632 and lying in a crowded region of the Galactic plane where there is prominent diffuse emission. We formulated amore » Bayesian block algorithm adapted to work with weighted photon counts, in order to define the off-pulse phases of PSR J0633+0632. A detailed spectral-spatial model of a 5° circular region centred on the known location of HESS J0632+057 was generated to accurately model the LAT data. No significant emission from the location of HESS J0632+057 was detected in the 0.1–100 GeV energy range integrating over ~3.5 yr of data, with a 95 per cent flux upper limit of F0.1-100 GeV < 3 × 10 –8 ph cm –2 s –1. A search for emission over different phases of the orbit also yielded no significant detection. A search for source emission on shorter time-scales (days–months) did not yield any significant detections. We also report the results of a search for radio pulsations using the 100-m Green Bank Telescope. No periodic signals or individual dispersed bursts of a likely astronomical origin were detected. We estimated the flux density limit of < 90/40 μJy at 2/9 GHz. Furthermore, the LAT flux upper limits combined with the detection of HESS J0632+057 in the 136–400 TeV energy band by the MAGIC collaboration imply that the VHE spectrum must turn over at energies <136 GeV placing constraints on any theoretical models invoked to explain the γ-ray emission.« less

  7. Herpes Simplex Virus 2 Latency-Associated Transcript (LAT) region mutations do not identify a role for LAT-Associated Micro RNAs in viral reactivation in the Guinea Pig Genital Model.

    PubMed

    Kawamura, Yoshiki; Bosch-Marce, Marta; Tang, Shuang; Patel, Amita; Krause, Philip R

    2018-05-02

    Despite the long-standing observation that herpes simplex virus (HSV) Latency-Associated Transcript (LAT) promoter-deletion viruses show impaired recurrence phenotypes in relevant animal models, the mechanism by which these sequences exert this phenotypic effect is unknown. We constructed and evaluated four mutant HSV-2 viruses with targeted mutations in the LAT promoter and LAT-associated miRNAs affecting (1) the LAT TATA box, (2) the LAT ICP4-binding site, (3) miR-I and miR-II (miR-I/II), which both target ICP34.5, and (4) miR-III, which targets ICP0. While the LAT-TATA box mutant caused milder acute infections than wild-type (WT), there was no difference in recurrence phenotype between these viruses. LAT and miRNA expression during latency were not impaired by this mutation, suggesting that other promoter elements may be more important for latent HSV-2 LAT expression. Mutation of the LAT ICP4-binding site also did not cause an in vivo phenotypic difference between mutant and WT viruses. Acute infection and reactivation from latency of the miR-I/II mutant was similar to that of its rescuant, although slightly reduced in severity relative to the wild-type virus. The miR-III mutant also exhibited WT phenotypes in acute and recurrent phases of infection. While not ruling out an effect of these elements in human latency or reactivation, these findings do not identify a specific role for LAT or LAT-associated miRNAs in the HSV-2 LAT promoter deletion phenotype in guinea pigs. Thus, other sequences in this region may play a more important role in the long-studied LAT-associated phenotype in animals. IMPORTANCE While it has been known for several decades that specific HSV-1 and HSV-2 sequences near the LAT promoter are required for efficient viral reactivation in animal models, the mechanism is still not known. We constructed four mutant viruses with the goal of identifying critical sequence elements and of specifically testing the hypothesis that microRNAs that are

  8. Deriving the Contribution of Blazars to the Fermi-LAT Extragalactic γ-ray Background at E > 10 GeV with Efficiency Corrections and Photon Statistics

    NASA Astrophysics Data System (ADS)

    Di Mauro, M.; Manconi, S.; Zechlin, H.-S.; Ajello, M.; Charles, E.; Donato, F.

    2018-04-01

    The Fermi Large Area Telescope (LAT) Collaboration has recently released the Third Catalog of Hard Fermi-LAT Sources (3FHL), which contains 1556 sources detected above 10 GeV with seven years of Pass 8 data. Building upon the 3FHL results, we investigate the flux distribution of sources at high Galactic latitudes (| b| > 20^\\circ ), which are mostly blazars. We use two complementary techniques: (1) a source-detection efficiency correction method and (2) an analysis of pixel photon count statistics with the one-point probability distribution function (1pPDF). With the first method, using realistic Monte Carlo simulations of the γ-ray sky, we calculate the efficiency of the LAT to detect point sources. This enables us to find the intrinsic source-count distribution at photon fluxes down to 7.5 × 10‑12 ph cm‑2 s‑1. With this method, we detect a flux break at (3.5 ± 0.4) × 10‑11 ph cm‑2 s‑1 with a significance of at least 5.4σ. The power-law indexes of the source-count distribution above and below the break are 2.09 ± 0.04 and 1.07 ± 0.27, respectively. This result is confirmed with the 1pPDF method, which has a sensitivity reach of ∼10‑11 ph cm‑2 s‑1. Integrating the derived source-count distribution above the sensitivity of our analysis, we find that (42 ± 8)% of the extragalactic γ-ray background originates from blazars.

  9. Search For Gamma-Ray Emission From X-Ray-Selected Seyfert Galaxies With Fermi -LAT

    DOE PAGES

    Ackermann, M.

    2012-02-23

    We report on a systematic investigation of the γ-ray properties of 120 hard Xray– selected Seyfert galaxies classified as ‘radio-quiet’ objects, utilizing the threeyear accumulation of Fermi–LAT data. Our sample of Seyfert galaxies is selected using the Swift–BAT 58-month catalog, restricting the analysis to the bright sources with average hard X-ray fluxes F14-195 keV ≥ 2.5 × 10 -11 erg cm -2 s -1 at high Galactic latitudes (|b| > 10°). In order to remove ‘radio-loud’ objects from the sample, we use the ‘hard X-ray radio loudness parameter’, RrX , defined as the ratio of the total 1.4 GHz radiomore » to 14 - 195 keV hard X-ray energy fluxes. Among 120 X-ray bright Seyfert galaxies with RrX < 10-4, we did not find a statistically significant γ-ray excess (TS > 25) positionally coincident with any target Seyferts, with possible exceptions of ESO 323–G077 and NGC 6814. The mean value of the 95% confidence level γ-ray upper limit for the integrated photon flux above 100 MeV from the analyzed Seyferts is ≃ 4×10 -9 ph cm -2 s -1 , and the upper limits derived for several objects reach ≃ 1 × 10 -9 ph cm -2 s -1 . Our results indicate that no prominent γ-ray emission component related to active galactic nucleus activity is present in the spectra of Seyferts around GeV energies. The Fermi–LAT upper limits derived for our sample probe the ratio of γ-ray to X-ray luminosities L /LX < 0.1, and even < 0.01 in some cases. The obtained results impose novel constraints on the models for high energy radiation of ‘radio-quiet’ Seyfert galaxies.« less

  10. Fermi LAT detection of a GeV flare from the blazar PKS 0250-225

    NASA Astrophysics Data System (ADS)

    Dutka, Michael; Ojha, Roopesh

    2012-11-01

    The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar PKS 0250-225 (also known as 2FGL J0252.7-2218, Nolan et al. 2012 ApJS, 199, 31). PKS 0250-225 has the coordinates RA=02h52m47.9536s, DEC=-22d19m25.465s, J2000, (Beasley et al. 2002 ApJS, 141, 13) and redshift z=1.419 (Shaw et al.

  11. Fermi LAT detection of a new gamma-ray flare from FSRQ PKS 0502+049

    NASA Astrophysics Data System (ADS)

    Ojha, Roopesh; Dutka, Michael

    2013-03-01

    The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar PKS 0502+049 (also known as 2FGL J0505.5+0501, Nolan et al. 2012 ApJS, 199, 31). PKS 0502+049 has coordinates RA=05h05m23.1847s DEC=+04d59m42.725s, J2000, (Johnston et al. 1995, AJ, 110, 880) and redshift z=0.954 (Drinkwater et al.

  12. SUZAKU X-RAY FOLLOW-UP OBSERVATIONS OF SEVEN UNASSOCIATED FERMI-LAT GAMMA-RAY SOURCES AT HIGH GALACTIC LATITUDES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Takahashi, Y.; Kataoka, J.; Nakamori, T.

    2012-03-01

    We report on our second-year campaign of X-ray follow-up observations of unidentified Fermi Large Area Telescope (LAT) {gamma}-ray sources at high Galactic latitudes (|b| > 10 Degree-Sign ) using the X-ray Imaging Spectrometer on board the Suzaku X-ray Observatory. In this second year of the project, seven new targets were selected from the First Fermi-LAT Catalog, and studied with 20-40 ks effective Suzaku exposures. We detected an X-ray point source coincident with the position of the recently discovered millisecond pulsar (MSP) PSR J2302+4442 within the 95% confidence error circle of 1FGL J2302.8+4443. The X-ray spectrum of the detected counterpart wasmore » well fit by a blackbody model with temperature of kT {approx_equal} 0.3 keV, consistent with an origin of the observed X-ray photons from the surface of a rotating magnetized neutron star. For four other targets that were also recently identified with a normal pulsar (1FGL J0106.7+4853) and MSPs (1FGL J1312.6+0048, J1902.0-5110, and J2043.2+1709), only upper limits in the 0.5-10 keV band were obtained at the flux levels of {approx_equal} 10{sup -14} erg cm{sup -2} s{sup -1}. A weak X-ray source was found in the field of 1FGL J1739.4+8717, but its association with the variable {gamma}-ray emitter could not be confirmed with the available Suzaku data alone. For the remaining Fermi-LAT object 1FGL J1743.8-7620 no X-ray source was detected within the LAT 95% error ellipse. We briefly discuss the general properties of the observed high Galactic-latitude Fermi-LAT objects by comparing their multiwavelength properties with those of known blazars and MSPs.« less

  13. Fermi-LAT Observations of High-Energy Gamma-Ray Emission Toward the Galactic Center

    DOE PAGES

    Ajello, M.

    2016-02-26

    The Fermi Large Area Telescope (LAT) has provided the most detailed view to date of the emission towards the Galactic centre (GC) in high-energy γ-rays. This paper describes the analysis of data taken during the first 62 months of the mission in the energy range 1 - 100 GeV from a 15° X15° region about the direction of the GC, and implications for the interstellar emissions produced by cosmic ray (CR) particles interacting with the gas and radiation fields in the inner Galaxy and for the point sources detected. Specialised interstellar emission models (IEMs) are constructed that enable separation ofmore » the γ-ray emission from the inner ~ 1 kpc about the GC from the fore- and background emission from the Galaxy. Based on these models, the interstellar emission from CR electrons interacting with the interstellar radiation field via the inverse Compton (IC) process and CR nuclei inelastically scattering off the gas producing γ-rays via π⁰ decays from the inner ~ 1 kpc is determined. The IC contribution is found to be dominant in the region and strongly enhanced compared to previous studies. A catalog of point sources for the 15 °X 15 °region is self-consistently constructed using these IEMs: the First Fermi–LAT Inner Galaxy point source Catalog (1FIG). The spatial locations, fluxes, and spectral properties of the 1FIG sources are presented, and compared with γ-ray point sources over the same region taken from existing catalogs, including the Third Fermi–LAT Source Catalog (3FGL). In general, the spatial density of 1FIG sources differs from those in the 3FGL, which is attributed to the different treatments of the interstellar emission and energy ranges used by the respective analyses. Three 1FIG sources are found to spatially overlap with supernova remnants (SNRs) listed in Green’s SNR catalog; these SNRs have not previously been associated with high-energy γ-ray sources. Most 3FGL sources with known multi-wavelength counterparts are also found

  14. Analysis of Voyager Observed High-Energy Electron Fluxes in the Heliosheath Using MHD Simulations

    NASA Technical Reports Server (NTRS)

    Washimi, Haruichi; Webber, W. R.; Zank, Gary P.; Hu, Qiang; Florinski, Vladimir; Adams, James; Kubo, Yuki

    2011-01-01

    The Voyager spacecraft (V1 and V2) observed electrons of 6-14 MeV in the heliosheath which showed several incidences of flux variation relative to a background of gradually increasing flux with distance from the Sun. The increasing flux of background electrons is thought to result from inward radial diffusion. We compare the temporal electron flux variation with dynamical phenomena in the heliosheath that are obtained from our MHD simulations. Because our simulation is based on V2 observed plasma data before V2 crossed the termination shock, this analysis is effective up to late 2008, i.e., about a year after the V2-crossing, during which disturbances, driven prior to the crossing time, survived in the heliosheath. Several electron flux variations correspond to times directly associated with interplanetary shock events. One noteworthy example corresponds to various times associated with the March 2006 interplanetary shock, these being the collision with the termination shock, the passage past the V1 spacecraft, and the collision with the region near the heliopause, as identified by W.R. Webber et al. for proton/helium of 7-200 MeV. Our simulations indicate that all other electron flux variations, except one, correspond well to the times when a shock-driven magneto-sonic pulse and its reflection in the heliosheath either passed across V1/V2, or collided with the termination shock or with the plasma sheet near the heliopause. This result suggests that variation in the electron flux should be due to either direct or indirect effects of magnetosonic pulses in the heliosheath driven by interplanetary shocks

  15. Deriving the Contribution of Blazars to the Fermi-LAT Extragalactic γ-ray Background at E > 10 GeV with Efficiency Corrections and Photon Statistics

    DOE PAGES

    Di Mauro, M.; Manconi, S.; Zechlin, H. -S.; ...

    2018-03-29

    Here, the Fermi Large Area Telescope (LAT) Collaboration has recently released the Third Catalog of Hard Fermi-LAT Sources (3FHL), which contains 1556 sources detected above 10 GeV with seven years of Pass 8 data. Building upon the 3FHL results, we investigate the flux distribution of sources at high Galactic latitudes (more » $$|b| \\gt 20^\\circ $$), which are mostly blazars. We use two complementary techniques: (1) a source-detection efficiency correction method and (2) an analysis of pixel photon count statistics with the one-point probability distribution function (1pPDF). With the first method, using realistic Monte Carlo simulations of the γ-ray sky, we calculate the efficiency of the LAT to detect point sources. This enables us to find the intrinsic source-count distribution at photon fluxes down to 7.5 × 10 –12 ph cm –2 s –1. With this method, we detect a flux break at (3.5 ± 0.4) × 10 –11 ph cm –2 s –1 with a significance of at least 5.4σ. The power-law indexes of the source-count distribution above and below the break are 2.09 ± 0.04 and 1.07 ± 0.27, respectively. This result is confirmed with the 1pPDF method, which has a sensitivity reach of ~10 –11 ph cm –2 s –1. Integrating the derived source-count distribution above the sensitivity of our analysis, we find that (42 ± 8)% of the extragalactic γ-ray background originates from blazars.« less

  16. Deriving the Contribution of Blazars to the Fermi-LAT Extragalactic γ-ray Background at E > 10 GeV with Efficiency Corrections and Photon Statistics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Di Mauro, M.; Manconi, S.; Zechlin, H. -S.

    Here, the Fermi Large Area Telescope (LAT) Collaboration has recently released the Third Catalog of Hard Fermi-LAT Sources (3FHL), which contains 1556 sources detected above 10 GeV with seven years of Pass 8 data. Building upon the 3FHL results, we investigate the flux distribution of sources at high Galactic latitudes (more » $$|b| \\gt 20^\\circ $$), which are mostly blazars. We use two complementary techniques: (1) a source-detection efficiency correction method and (2) an analysis of pixel photon count statistics with the one-point probability distribution function (1pPDF). With the first method, using realistic Monte Carlo simulations of the γ-ray sky, we calculate the efficiency of the LAT to detect point sources. This enables us to find the intrinsic source-count distribution at photon fluxes down to 7.5 × 10 –12 ph cm –2 s –1. With this method, we detect a flux break at (3.5 ± 0.4) × 10 –11 ph cm –2 s –1 with a significance of at least 5.4σ. The power-law indexes of the source-count distribution above and below the break are 2.09 ± 0.04 and 1.07 ± 0.27, respectively. This result is confirmed with the 1pPDF method, which has a sensitivity reach of ~10 –11 ph cm –2 s –1. Integrating the derived source-count distribution above the sensitivity of our analysis, we find that (42 ± 8)% of the extragalactic γ-ray background originates from blazars.« less

  17. Energetic electron precipitation characteristics observed from Antarctica during a flux dropout event

    NASA Astrophysics Data System (ADS)

    Clilverd, Mark A.; Cobbett, Neil; Rodger, Craig J.; Brundell, James B.; Denton, Michael H.; Hartley, David P.; Rodriguez, Juan V.; Danskin, Donald; Raita, Tero; Spanswick, Emma L.

    2013-11-01

    from two autonomous VLF radio receiver systems installed in a remote region of the Antarctic in 2012 is used to take advantage of the juxtaposition of the L = 4.6 contour, and the Hawaii-Halley, Antarctica, great circle path as it passes over thick Antarctic ice shelf. The ice sheet conductivity leads to high sensitivity to changing D region conditions, and the quasi constant L shell highlights outer radiation belt processes. The ground-based instruments observed several energetic electron precipitation events over a moderately active 24 h period, during which the outer radiation belt electron flux declined at most energies and subsequently recovered. Combining the ground-based data with low and geosynchronous orbiting satellite observations on 27 February 2012, different driving mechanisms were observed for three precipitation events with clear signatures in phase space density and electron anisotropy. Comparison between flux measurements made by Polar-orbiting Operational Environmental Satellites (POES) in low Earth orbit and by the Antarctic instrumentation provides evidence of different cases of weak and strong diffusion into the bounce loss cone, helping to understand the physical mechanisms controlling the precipitation of energetic electrons into the atmosphere. Strong diffusion events occurred as the <600 keV fluxes began to recover as a result of adiabatic transport of electrons. One event appeared to have a factor of about 10 to 100 times more flux than was reported by POES, consistent with weak diffusion into the bounce loss cone. Two events had a factor of about 3 to 10 times more >30 keV flux than was reported by POES, more consistent with strong diffusion conditions.

  18. Extensive electron transport and energization via multiple, localized dipolarizing flux bundles

    NASA Astrophysics Data System (ADS)

    Gabrielse, Christine; Angelopoulos, Vassilis; Harris, Camilla; Artemyev, Anton; Kepko, Larry; Runov, Andrei

    2017-05-01

    Using an analytical model of multiple dipolarizing flux bundles (DFBs) embedded in earthward traveling bursty bulk flows, we demonstrate how equatorially mirroring electrons can travel long distances and gain hundreds of keV from betatron acceleration. The model parameters are constrained by four Time History of Events and Macroscale Interactions during Substorms satellite observations, putting limits on the DFBs' speed, location, and magnetic and electric field magnitudes. We find that the sharp, localized peaks in magnetic field have such strong spatial gradients that energetic electrons ∇B drift in closed paths around the peaks as those peaks travel earthward. This is understood in terms of the third adiabatic invariant, which remains constant when the field changes on timescales longer than the electron's drift timescale: An energetic electron encircles a sharp peak in magnetic field in a closed path subtending an area of approximately constant flux. As the flux bundle magnetic field increases the electron's drift path area shrinks and the electron is prevented from escaping to the ambient plasma sheet, while it continues to gain energy via betatron acceleration. When the flux bundles arrive at and merge with the inner magnetosphere, where the background field is strong, the electrons suddenly gain access to previously closed drift paths around the Earth. DFBs are therefore instrumental in transporting and energizing energetic electrons over long distances along the magnetotail, bringing them to the inner magnetosphere and energizing them by hundreds of keV.Plain Language SummaryScientists have wondered how narrow flow channels in space could transport and energize <span class="hlt">electrons</span> enough before the <span class="hlt">electrons</span> escape the channel. They also wondered how narrow, localized magnetic field peaks (and their electric fields) contribute to <span class="hlt">electron</span> energization in comparison to wide, large-scale electromagnetic fields. We show</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016cosp...41E1150L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016cosp...41E1150L"><span>Fermi-<span class="hlt">LAT</span> observation on magnetars and associated SNRs</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Li, Jian; Rea, Nanda; De Ona Wilhelmi, Emma; Torres, Diego F.</p> <p>2016-07-01</p> <p>We report on the search for gamma-ray emission from several magnetars using 6 years of Fermi Large Area Telescope (<span class="hlt">LAT</span>) observations. No significant evidence for gamma-ray emission from any of the currently-known magnetars was found. We derived the most stringent upper limits to date on the 0.1-300 GeV emission from Galactic magnetars, which are estimated between ˜10^{-12} - 10^{-11} erg cm^{-2} s^{-1}. Gamma-ray pulsations were searched for the few sources having reliable ephemerides over the observing period, but none were detected. On the other hand, we studied the gamma-ray morphology and spectra of six SNRs associated with or adjacent to magnetars (namely: CTB109, Kes 73, W41, G337.0-00.1, HB9 and CTB 37A), that have 0.1-300 GeV <span class="hlt">fluxes</span> between 1.5-14×10^{-11} erg cm^{-2} s^{-1}.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/22322188','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/22322188"><span>Canine <span class="hlt">Lat</span>1: molecular structure, distribution and its expression in cancer samples.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ochiai, Hideharu; Morishita, Taiki; Onda, Ken; Sugiyama, Hiroki; Maruo, Takuya</p> <p>2012-07-01</p> <p>A full-length cDNA sequence of canine L-type amino acid transporter 1 (<span class="hlt">Lat</span>1) was determined from a canine brain. The sequence was 1828 bp long and was predicted to encode 485 amino acid polypeptides. The deduced amino acid sequence of canine <span class="hlt">Lat</span>1 showed 93.2% and 91.1% similarities to those of humans and rats, respectively. Northern blot analysis detected <span class="hlt">Lat</span>1 expression in the cerebellum at 4 kb, and Western blot analysis showed a single band at 40 kDa. RT-PCR analysis revealed a distinct expression of <span class="hlt">Lat</span>1 in the pancreas and testis in addition to the cerebrum and cerebellum. Notably, <span class="hlt">Lat</span>1 expression was observed in the tissues of thyroid cancer, melanoma and hemangiopericytoma. Although the cancer samples examined were not enough, <span class="hlt">Lat</span>1 may serve as a useful biomarker of cancer cells in veterinary clinic.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li class="active"><span>6</span></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_6 --> <div id="page_7" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li class="active"><span>7</span></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="121"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22375747-implications-fermi-lat-observations-origin-icecube-neutrinos','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22375747-implications-fermi-lat-observations-origin-icecube-neutrinos"><span>Implications of Fermi-<span class="hlt">LAT</span> observations on the origin of IceCube neutrinos</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Wang, Bin; Li, Zhuo; Zhao, Xiaohong, E-mail: wang_b@pku.edu.cn, E-mail: zhaoxh@ynao.ac.cn, E-mail: zhuo.li@pku.edu.cn</p> <p>2014-11-01</p> <p>The IceCube (IC) collaboration recently reported the detection of TeV-PeV extraterrestrial neutrinos whose origin is yet unknown. By the photon-neutrino connection in pp and pγ interactions, we use the Fermi-<span class="hlt">LAT</span> observations to constrain the origin of the IC detected neutrinos. We find that Galactic origins, i.e., the diffuse Galactic neutrinos due to cosmic ray (CR) propagation in the Milky Way, and the neutrinos from the Galactic point sources, may not produce the IC neutrino <span class="hlt">flux</span>, thus these neutrinos should be of extragalactic origin. Moreover, the extragalactic gamma-ray bursts (GRBs) may not account for the IC neutrino <span class="hlt">flux</span>, the jets ofmore » active galactic nuclei may not produce the IC neutrino spectrum, but the starburst galaxies (SBGs) may be promising sources. As suggested by the consistency between the IC detected neutrino <span class="hlt">flux</span> and the Waxman-Bahcall bound, GRBs in SBGs may be the sources of both the ultrahigh energy, ∼> 10{sup 19}eV, CRs and the 1–100 PeV CRs that produce the IC detected TeV-PeV neutrinos.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22680115-dipole-anisotropy-cosmic-electrons-positrons-inspection-local-sources','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22680115-dipole-anisotropy-cosmic-electrons-positrons-inspection-local-sources"><span>Dipole anisotropy in cosmic <span class="hlt">electrons</span> and positrons: inspection on local sources</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Manconi, S.; Donato, F.; Mauro, M. Di, E-mail: manconi@to.infn.it, E-mail: mdimauro@slac.stanford.edu, E-mail: donato@to.infn.it</p> <p></p> <p>The cosmic <span class="hlt">electrons</span> and positrons have been measured with unprecedented statistics up to several hundreds GeV, thus permitting to explore the role that close single sources can have in shaping the <span class="hlt">flux</span> at different energies. In the present analysis, we consider <span class="hlt">electrons</span> and positrons in cosmic rays to be produced by spallations of hadron <span class="hlt">fluxes</span> with the interstellar medium, by a smooth Supernova Remnant (SNR) population, by all the ATNF catalog pulsars, and by few discrete, local SNRs. We test several source models on the e {sup ++} e {sup −} and e {sup +} AMS-02 <span class="hlt">flux</span> data. For themore » configurations compatible with the data, we compute the dipole anisotropy in e {sup ++} e {sup −}, e {sup +}, e {sup +}/ e {sup −} from single sources. Our study includes a dedicated analysis to the Vela SNR. We show that Fermi -<span class="hlt">LAT</span> present data on dipole anisotropy of e {sup ++} e {sup −} start to explore some of the models for the Vela SNR selected by AMS-02 <span class="hlt">flux</span> data. We also investigate how the observed anisotropy could result from a combination of local sources. Our analysis shows that the search of anisotropy in the lepton <span class="hlt">fluxes</span> up to TeV energies can be an interesting tool for the inspection of properties of close SNRs, complementary to the high precision <span class="hlt">flux</span> data.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1355715','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1355715"><span>Search for gamma-ray emission from AE Aquarii with seven year of Fermi <span class="hlt">LAT</span> observations</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Li, Jian; Torres, Diego F.; Rea, Nanda</p> <p>2016-11-14</p> <p>AE Aquarii (AE Aqr) is a cataclysmic binary hosting one of the fastest rotating (more » $${P}_{\\mathrm{spin}}$$ = 33.08 s) white dwarfs (WDs) known. Based on seven years of Fermi Large Area Telescope (<span class="hlt">LAT</span>) Pass 8 data, we report on a deep search for gamma-ray emission from AE Aqr. When using X-ray observations from ASCA, XMM-Newton, Chandra, Swift, Suzaku, and NuSTAR, spanning 20 years, we substantially extend and improve the spin ephemeris of AE Aqr. Using this ephemeris, we searched for gamma-ray pulsations at the spin period of the WD. We detected no gamma-ray pulsations above 3σ significance. Neither phase-averaged gamma-ray emission nor gamma-ray variability of AE Aqr is detected by Fermi <span class="hlt">LAT</span>. We also impose the most restrictive upper limit to the gamma-ray <span class="hlt">flux</span> from AE Aqr to date: $$1.3\\times {10}^{-12}$$ erg cm -2 s -1 in the 100 MeV–300 GeV energy range, providing constraints on models.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1355694-fermi-lat-observations-ligo-event-gw150914','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1355694-fermi-lat-observations-ligo-event-gw150914"><span>Fermi-<span class="hlt">LAT</span> Observations of the LIGO Event GW150914</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Ackermann, M.; Ajello, M.; Albert, A.; ...</p> <p>2016-05-12</p> <p>The Fermi Large Area Telescope (<span class="hlt">LAT</span>) has an instantaneous field of view (FoV) covering ~1/5 of the sky and it completes a survey of the entire sky in high-energy gamma-rays every 3 hr. It enables searches for transient phenomena over timescales from milliseconds to years. Among these phenomena could be electromagnetic counterparts to gravitational wave (GW) sources. In this study, we present a detailed study of the <span class="hlt">LAT</span> observations relevant to Laser Interferometer Gravitational-wave Observatory (LIGO) event GW150914, which is the first direct detection of gravitational waves and has been interpreted as being due to the coalescence of two stellar-massmore » black holes. The localization region for GW150914 was outside the <span class="hlt">LAT</span> FoV at the time of the GW signal. However, as part of routine survey observations, the <span class="hlt">LAT</span> observed the entire LIGO localization region within ~70 minutes of the trigger and thus enabled a comprehensive search for a γ-ray counterpart to GW150914. Finally, the study of the <span class="hlt">LAT</span> data presented here did not find any potential counterparts to GW150914, but it did provide limits on the presence of a transient counterpart above 100 MeV on timescales of hours to days over the entire GW150914 localization region.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20170004000&hterms=fisica&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dfisica','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20170004000&hterms=fisica&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dfisica"><span>Fermi-<span class="hlt">LAT</span> Observations of the LIGO Event GW150914</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ackermann, M.; Ajello, M.; Albert, A.; Anderson, B.; Arimoto, M.; Atwood, W. B.; Axelsson, M.; Baldini, L.; Ballet, J.; Barbiellini, G.; <a style="text-decoration: none; " href="javascript:void(0); " onClick="displayelement('author_20170004000'); toggleEditAbsImage('author_20170004000_show'); toggleEditAbsImage('author_20170004000_hide'); "> <img style="display:inline; width:12px; height:12px; " src="images/arrow-up.gif" width="12" height="12" border="0" alt="hide" id="author_20170004000_show"> <img style="width:12px; height:12px; display:none; " src="images/arrow-down.gif" width="12" height="12" border="0" alt="hide" id="author_20170004000_hide"></p> <p>2016-01-01</p> <p>The Fermi Large Area Telescope (<span class="hlt">LAT</span>) has an instantaneous field of view (FoV) covering 1 5 of the sky and it completes a survey of the entire sky in high-energy gamma-rays every 3 hr. It enables searches for transient phenomena over timescales from milliseconds to years. Among these phenomena could be electromagnetic counterparts to gravitational wave (GW) sources. In this paper, we present a detailed study of the <span class="hlt">LAT</span> observations relevant to Laser Interferometer Gravitational-wave Observatory (LIGO) event GW150914, which is the first direct detection of gravitational waves and has been interpreted as being due to the coalescence of two stellar-mass black holes. The localization region for GW150914 was outside the <span class="hlt">LAT</span> FoV at the time of the GW signal. However, as part of routine survey observations, the <span class="hlt">LAT</span> observed the entire LIGO localization region within approx. 70 minutes of the trigger and thus enabled a comprehensive search for a gamma-ray counterpart to GW150914.The study of the <span class="hlt">LAT</span> data presented here did not find any potential counterparts to GW150914, but it did provide limits on the presence of a transient counterpart above 100 MeV on timescales of hours to days over the entire GW150914 localization region.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/AD1039276','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/AD1039276"><span><span class="hlt">Lat</span>Mix 2011 and 2012 Dispersion Analysis</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2017-05-15</p> <p>was to complete the analysis and write -up of additional manuscripts relating to <span class="hlt">Lat</span>Mix, and to further strengthen the results for multiple manuscripts...versus a propagation of energy upwards from small mixing events (e.g., via generation of vo rtices). A key technical goal of our work was to develop...raw waveforms co llected during the <span class="hlt">Lat</span>Mix 20 l I airborne lidar surveys, and completion of the analysis and write -up of major results stemming from</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25628642','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25628642"><span>New genetic variants of <span class="hlt">LATS</span>1 detected in urinary bladder and colon cancer.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Saadeldin, Mona K; Shawer, Heba; Mostafa, Ahmed; Kassem, Neemat M; Amleh, Asma; Siam, Rania</p> <p>2014-01-01</p> <p><span class="hlt">LATS</span>1, the large tumor suppressor 1 gene, encodes for a serine/threonine kinase protein and is implicated in cell cycle progression. <span class="hlt">LATS</span>1 is down-regulated in various human cancers, such as breast cancer, and astrocytoma. Point mutations in <span class="hlt">LATS</span>1 were reported in human sarcomas. Additionally, loss of heterozygosity of <span class="hlt">LATS</span>1 chromosomal region predisposes to breast, ovarian, and cervical tumors. In the current study, we investigated <span class="hlt">LATS</span>1 genetic variations including single nucleotide polymorphisms (SNPs), in 28 Egyptian patients with either urinary bladder or colon cancers. The <span class="hlt">LATS</span>1 gene was amplified and sequenced and the expression of <span class="hlt">LATS</span>1 at the RNA level was assessed in 12 urinary bladder cancer samples. We report, the identification of a total of 29 variants including previously identified SNPs within <span class="hlt">LATS</span>1 coding and non-coding sequences. A total of 18 variants were novel. Majority of the novel variants, 13, were mapped to intronic sequences and un-translated regions of the gene. Four of the five novel variants located in the coding region of the gene, represented missense mutations within the serine/threonine kinase catalytic domain. Interestingly, <span class="hlt">LATS</span>1 RNA steady state levels was lost in urinary bladder cancerous tissue harboring four specific SNPs (16045 + 41736 + 34614 + 56177) positioned in the 5'UTR, intron 6, and two silent mutations within exon 4 and exon 8, respectively. This study identifies novel single-base-sequence alterations in the <span class="hlt">LATS</span>1 gene. These newly identified variants could potentially be used as novel diagnostic or prognostic tools in cancer.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28984391','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28984391"><span>Tuning <span class="hlt">Electron</span> <span class="hlt">Flux</span> through Nitrogenase with Methanogen Iron Protein Homologues.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hiller, Caleb J; Stiebritz, Martin T; Lee, Chi Chung; Liedtke, Jasper; Hu, Yilin</p> <p>2017-11-16</p> <p>Nitrogenase uses a reductase component called Fe protein to deliver <span class="hlt">electrons</span> to its catalytic partner for substrate reduction. The essential role of Fe protein in catalysis makes it an ideal target for regulating the <span class="hlt">electron</span> <span class="hlt">flux</span> and enzymatic activity of nitrogenase without perturbing the cofactor site. This work reports that hybrids between the Fe protein homologs of Methanosarcina acetivorans and the catalytic components of Azotobacter vinelandii can trap substrate CO through reduced <span class="hlt">electron</span> <span class="hlt">fluxes</span>. In addition, homology modeling/in silico docking is used to define markers for binding energy and specificity between the component proteins that correlate with the experimentally determined activities. This homologue-based approach could be further developed to allow identification or design of hybrids between homologous nitrogenase components for mechanistic investigations of nitrogenase through capture of substrates/ intermediates or for transgenic expression of nitrogenase through synthetic biology. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017PhRvD..96f3009C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017PhRvD..96f3009C"><span>Realistic estimation for the detectability of dark matter subhalos using Fermi-<span class="hlt">LAT</span> catalogs</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Calore, Francesca; De Romeri, Valentina; Di Mauro, Mattia; Donato, Fiorenza; Marinacci, Federico</p> <p>2017-09-01</p> <p>Numerical simulations of structure formation have made remarkable progress in recent years, in particular due to the inclusion of baryonic physics evolving with the dark matter component. We generate Monte Carlo realizations of the dark matter subhalo population based on the results of the recent hydrodynamical simulation suite of Milky Way-sized galaxies [F. Marinacci, R. Pakmor, and V. Springel, Mon. Not. R. Astron. Soc. 437, 1750 (2014)., 10.1093/mnras/stt2003]. We then simulate the gamma-ray sky for both the setup of the 3FGL and 2FHL Fermi Large Area Telescope (<span class="hlt">LAT</span>) catalogs, including the contribution from the annihilation of dark matter in the subhalos. We find that the <span class="hlt">flux</span> sensitivity threshold strongly depends on the particle dark matter mass and, more mildly, also on its annihilation channel and the observation latitude. The results differ for the 3FGL and 2FHL catalogs, given their different energy thresholds. We also predict that the number of dark matter subhalos among the unassociated sources is very small. A null number of detectable subhalos in the Fermi-<span class="hlt">LAT</span> 3FGL catalog would imply upper limits on the dark matter annihilation cross section into b b ¯ of 2 ×10-26(5 ×10-25) cm3 /s with MDM=50 (1000 ) GeV . We find less than one extended subhalo in the Fermi-<span class="hlt">LAT</span> 3FGL catalog. As a matter of fact, the differences in the spatial and mass distribution of subhalos between hydrodynamic and dark matter-only runs do not have significant impact on the detectability of dark subhalos in gamma rays.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013ATel.4941....1O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013ATel.4941....1O"><span>Fermi <span class="hlt">LAT</span> detection of a gamma-ray flare from FSRQ S5 1044+71</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ojha, Roopesh; Carpenter, Bryce; Dutka, Michael</p> <p>2013-04-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray <span class="hlt">flux</span> from a source positionally consistent with the flat spectrum radio quasar S5 1044+71 (also known as 2FGL J1048.3+7144, Nolan et al. 2012, ApJS, 199, 31). Localization analysis has ruled out the nearby source 2FGL J1049.7+7240 as a possible counterpart. S5 1044+71 has coordinates RA=10h48m27.6199s DEC=+71d43m35.938s, J2000, (Johnston et al.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1183079-thermal-flux-limited-electron-kapitza-conductance-copper-niobium-multilayers','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1183079-thermal-flux-limited-electron-kapitza-conductance-copper-niobium-multilayers"><span>Thermal <span class="hlt">flux</span> limited <span class="hlt">electron</span> Kapitza conductance in copper-niobium multilayers</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Cheaito, Ramez; Hattar, Khalid Mikhiel; Gaskins, John T.; ...</p> <p>2015-03-05</p> <p>The interplay between the contributions of <span class="hlt">electron</span> thermal <span class="hlt">flux</span> and interface scattering to the Kapitza conductance across metal-metal interfaces through measurements of thermal conductivity of copper-niobium multilayers was studied. Thermal conductivities of copper-niobium multilayer films of period thicknesses ranging from 5.4 to 96.2 nm and sample thicknesses ranging from 962 to 2677 nm are measured by time-domain thermoreflectance over a range of temperatures from 78 to 500 K. The Kapitza conductances between the Cu and Nb interfaces in multilayer films are determined from the thermal conductivities using a series resistor model and are in good agreement with the <span class="hlt">electron</span> diffusemore » mismatch model. The results for the thermal boundary conductance between Cu and Nb are compared to literature values for the thermal boundary conductance across Al-Cu and Pd-Ir interfaces, and demonstrate that the interface conductance in metallic systems is dictated by the temperature derivative of the <span class="hlt">electron</span> energy <span class="hlt">flux</span> in the metallic layers, rather than <span class="hlt">electron</span> mean free path or scattering processes at the interface.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1997PhPl....4.4331S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1997PhPl....4.4331S"><span><span class="hlt">Electron</span> transport <span class="hlt">fluxes</span> in potato plateau regime</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Shaing, K. C.; Hazeltine, R. D.</p> <p>1997-12-01</p> <p><span class="hlt">Electron</span> transport <span class="hlt">fluxes</span> in the potato plateau regime are calculated from the solutions of the drift kinetic equation and fluid equations. It is found that the bootstrap current density remains finite in the region close to the magnetic axis, although it decreases with increasing collision frequency. This finite amount of the bootstrap current in the relatively collisional regime is important in modeling tokamak startup with 100% bootstrap current.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20020022517&hterms=balance+sheet&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D60%26Ntt%3Dbalance%2Bsheet','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20020022517&hterms=balance+sheet&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D60%26Ntt%3Dbalance%2Bsheet"><span><span class="hlt">Electron</span> Heat <span class="hlt">Flux</span> in Pressure Balance Structures at Ulysses</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Yamauchi, Yohei; Suess, Steven T.; Sakurai, Takashi; Whitaker, Ann F. (Technical Monitor)</p> <p>2001-01-01</p> <p>Pressure balance structures (PBSs) are a common feature in the high-latitude solar wind near solar minimum. Rom previous studies, PBSs are believed to be remnants of coronal plumes and be related to network activity such as magnetic reconnection in the photosphere. We investigated the magnetic structures of the PBSs, applying a minimum variance analysis to Ulysses/Magnetometer data. At 2001 AGU Spring meeting, we reported that PBSs have structures like current sheets or plasmoids, and suggested that they are associated with network activity at the base of polar plumes. In this paper, we have analyzed high-energy <span class="hlt">electron</span> data at Ulysses/SWOOPS to see whether bi-directional <span class="hlt">electron</span> flow exists and confirm the conclusions more precisely. As a result, although most events show a typical <span class="hlt">flux</span> directed away from the Sun, we have obtained evidence that some PBSs show bi-directional <span class="hlt">electron</span> <span class="hlt">flux</span> and others show an isotropic distribution of <span class="hlt">electron</span> pitch angles. The evidence shows that plasmoids are flowing away from the Sun, changing their flow direction dynamically in a way not caused by Alfven waves. From this, we have concluded that PBSs are generated due to network activity at the base of polar plumes and their magnetic structures axe current sheets or plasmoids.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFMSM43B2723B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFMSM43B2723B"><span>Magnetic Local Time Dependant Low Energy <span class="hlt">Electron</span> <span class="hlt">Flux</span> Models at Geostationary Earth Orbit</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Boynton, R.; Balikhin, M. A.; Walker, S. N.</p> <p>2017-12-01</p> <p>The low energy <span class="hlt">electron</span> <span class="hlt">fluxes</span> in the outer radiation belts at Geostationary Earth Orbit (GEO) can vary widely in Magnetic Local Time (MLT). This spatial variation is due to the convective and substorm-associated electric fields and can take place on short time scales. This makes it difficult to deduce a data based model of the low energy <span class="hlt">electrons</span>. For higher energies, where there is negligible spatial variation at a particular L-star, data based models employ averaged <span class="hlt">fluxes</span> over the orbit. This removes the diurnal variation as GEO passes through various L-star due to the structure of Earth's magnetic field. This study develops a number of models for the low energy <span class="hlt">electron</span> <span class="hlt">fluxes</span> measured by GOES 13 and 15 for different MLT to capture the dynamics of the spatial variations.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017APS..DPPBO7015H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017APS..DPPBO7015H"><span>Heat-<span class="hlt">Flux</span> Measurements in Laser-Produced Plasmas Using Thomson Scattering from <span class="hlt">Electron</span> Plasma Waves</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Henchen, R. J.; Goncharov, V. N.; Cao, D.; Katz, J.; Froula, D. H.; Rozmus, W.</p> <p>2017-10-01</p> <p>An experiment was designed to measure heat <span class="hlt">flux</span> in coronal plasmas using collective Thomson scattering. Adjustments to the <span class="hlt">electron</span> distribution function resulting from heat <span class="hlt">flux</span> affect the shape of the collective Thomson scattering features through wave-particle resonance. The amplitude of the Spitzer-Härm <span class="hlt">electron</span> distribution function correction term (f1) was varied to match the data and determines the value of the heat <span class="hlt">flux</span>. Independent measurements of temperature and density obtained from Thomson scattering were used to infer the classical heat <span class="hlt">flux</span> (q = - κ∇Te) . Time-resolved Thomson-scattering data were obtained at five locations in the corona along the target normal in a blowoff plasma formed from a planar Al target with 1.5 kJ of 351-nm laser light in a 2-ns square pulse. The <span class="hlt">flux</span> measured through the Thomson-scattering spectra is a factor of 5 less than the κ∇Te measurements. The lack of collisions of heat-carrying <span class="hlt">electrons</span> suggests a nonlocal model is needed to accurately describe the heat <span class="hlt">flux</span>. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JGRA..123.3646S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JGRA..123.3646S"><span>A Distributed Lag Autoregressive Model of Geostationary Relativistic <span class="hlt">Electron</span> <span class="hlt">Fluxes</span>: Comparing the Influences of Waves, Seed and Source <span class="hlt">Electrons</span>, and Solar Wind Inputs</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Simms, Laura; Engebretson, Mark; Clilverd, Mark; Rodger, Craig; Lessard, Marc; Gjerloev, Jesper; Reeves, Geoffrey</p> <p>2018-05-01</p> <p>Relativistic <span class="hlt">electron</span> <span class="hlt">flux</span> at geosynchronous orbit depends on enhancement and loss processes driven by ultralow frequency (ULF) Pc5, chorus, and electromagnetic ion cyclotron (EMIC) waves, seed <span class="hlt">electron</span> <span class="hlt">flux</span>, magnetosphere compression, the "Dst effect," and substorms, while solar wind inputs such as velocity, number density, and interplanetary magnetic field Bz drive these factors and thus correlate with <span class="hlt">flux</span>. Distributed lag regression models show the time delay of highest influence of these factors on log10 high-energy <span class="hlt">electron</span> <span class="hlt">flux</span> (0.7-7.8 MeV, Los Alamos National Laboratory satellites). Multiple regression with an autoregressive term (<span class="hlt">flux</span> persistence) allows direct comparison of the magnitude of each effect while controlling other correlated parameters. <span class="hlt">Flux</span> enhancements due to ULF Pc5 and chorus waves are of equal importance. The direct effect of substorms on high-energy <span class="hlt">electron</span> <span class="hlt">flux</span> is strong, possibly due to injection of high-energy <span class="hlt">electrons</span> by the substorms themselves. Loss due to electromagnetic ion cyclotron waves is less influential. Southward Bz shows only moderate influence when correlated processes are accounted for. Adding covariate compression effects (pressure and interplanetary magnetic field magnitude) allows wave-driven enhancements to be more clearly seen. Seed <span class="hlt">electrons</span> (270 keV) are most influential at lower relativistic energies, showing that such a population must be available for acceleration. However, they are not accelerated directly to the highest energies. Source <span class="hlt">electrons</span> (31.7 keV) show no direct influence when other factors are controlled. Their action appears to be indirect via the chorus waves they generate. Determination of specific effects of each parameter when studied in combination will be more helpful in furthering modeling work than studying them individually.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22660936-radio-diagnostics-electron-acceleration-sites-during-eruption-flux-rope-solar-corona','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22660936-radio-diagnostics-electron-acceleration-sites-during-eruption-flux-rope-solar-corona"><span>RADIO DIAGNOSTICS OF <span class="hlt">ELECTRON</span> ACCELERATION SITES DURING THE ERUPTION OF A <span class="hlt">FLUX</span> ROPE IN THE SOLAR CORONA</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Carley, Eoin P.; Gallagher, Peter T.; Vilmer, Nicole, E-mail: eoin.carley@obspm.fr</p> <p></p> <p><span class="hlt">Electron</span> acceleration in the solar corona is often associated with flares and the eruption of twisted magnetic structures known as <span class="hlt">flux</span> ropes. However, the locations and mechanisms of such particle acceleration during the flare and eruption are still subject to much investigation. Observing the exact sites of particle acceleration can help confirm how the flare and eruption are initiated and how they evolve. Here we use the Atmospheric Imaging Assembly to analyze a flare and erupting <span class="hlt">flux</span> rope on 2014 April 18, while observations from the Nançay Radio Astronomy Facility allow us to diagnose the sites of <span class="hlt">electron</span> acceleration duringmore » the eruption. Our analysis shows evidence of a pre-formed <span class="hlt">flux</span> rope that slowly rises and becomes destabilized at the time of a C-class flare, plasma jet, and the escape of ≳75 keV <span class="hlt">electrons</span> from the rope center into the corona. As the eruption proceeds, continued acceleration of <span class="hlt">electrons</span> with energies of ∼5 keV occurs above the <span class="hlt">flux</span> rope for a period over 5 minutes. At the flare peak, one site of <span class="hlt">electron</span> acceleration is located close to the flare site, while another is driven by the erupting <span class="hlt">flux</span> rope into the corona at speeds of up to 400 km s{sup −1}. Energetic <span class="hlt">electrons</span> then fill the erupting volume, eventually allowing the <span class="hlt">flux</span> rope legs to be clearly imaged from radio sources at 150–445 MHz. Following the analysis of Joshi et al. (2015), we conclude that the sites of energetic <span class="hlt">electrons</span> are consistent with <span class="hlt">flux</span> rope eruption via a tether cutting or <span class="hlt">flux</span> cancellation scenario inside a magnetic fan-spine structure. In total, our radio observations allow us to better understand the evolution of a <span class="hlt">flux</span> rope eruption and its associated <span class="hlt">electron</span> acceleration sites, from eruption initiation to propagation into the corona.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JGRA..123.1178K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JGRA..123.1178K"><span>An Energetic <span class="hlt">Electron</span> <span class="hlt">Flux</span> Dropout Due to Magnetopause Shadowing on 1 June 2013</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kang, Suk-Bin; Fok, Mei-Ching; Komar, Colin; Glocer, Alex; Li, Wen; Buzulukova, Natalia</p> <p>2018-02-01</p> <p>We examine the mechanisms responsible for the dropout of energetic <span class="hlt">electron</span> <span class="hlt">flux</span> during 31 May to 1 June 2013 using Van Allen Probe (Radiation Belt Storm Probes (RBSP)) <span class="hlt">electron</span> <span class="hlt">flux</span> data and simulations with the Comprehensive Inner Magnetosphere-Ionosphere (CIMI) model. During the storm main phase, L-shells at RBSP locations are greater than 8, which are connected to open drift shells. Consequently, diminished <span class="hlt">electron</span> <span class="hlt">fluxes</span> were observed over a wide range of energies. The combination of drift shell splitting, magnetopause shadowing, and drift loss all results in butterfly <span class="hlt">electron</span> pitch angle distributions (PADs) at the nightside. During storm sudden commencement, RBSP observations display <span class="hlt">electron</span> butterfly PADs over a wide range of energies. However, it is difficult to determine whether there are butterfly PADs during the storm main phase since the maximum observable equatorial pitch angle from RBSP is not larger than 40° during this period. To investigate the causes of the dropout, the CIMI model is used as a global 4-D kinetic inner magnetosphere model. The CIMI model reproduces the dropout with very similar timing and <span class="hlt">flux</span> levels and PADs along the RBSP trajectory for 593 keV. Furthermore, the CIMI simulation shows butterfly PADs for 593 keV during the storm main phase. Based on comparison of observations and simulations, we suggest that the dropout during this event mainly results from magnetopause shadowing.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014PhRvL.113l1102A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014PhRvL.113l1102A"><span><span class="hlt">Electron</span> and Positron <span class="hlt">Fluxes</span> in Primary Cosmic Rays Measured with the Alpha Magnetic Spectrometer on the International Space Station</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Aguilar, M.; Aisa, D.; Alvino, A.; Ambrosi, G.; Andeen, K.; Arruda, L.; Attig, N.; Azzarello, P.; Bachlechner, A.; Barao, F.; Barrau, A.; Barrin, L.; Bartoloni, A.; Basara, L.; Battarbee, M.; Battiston, R.; Bazo, J.; Becker, U.; Behlmann, M.; Beischer, B.; Berdugo, J.; Bertucci, B.; Bigongiari, G.; Bindi, V.; Bizzaglia, S.; Bizzarri, M.; Boella, G.; de Boer, W.; Bollweg, K.; Bonnivard, V.; Borgia, B.; Borsini, S.; Boschini, M. J.; Bourquin, M.; Burger, J.; Cadoux, F.; Cai, X. D.; Capell, M.; Caroff, S.; Casaus, J.; Cascioli, V.; Castellini, G.; Cernuda, I.; Cervelli, F.; Chae, M. J.; Chang, Y. H.; Chen, A. I.; Chen, H.; Cheng, G. M.; Chen, H. S.; Cheng, L.; Chikanian, A.; Chou, H. Y.; Choumilov, E.; Choutko, V.; Chung, C. H.; Clark, C.; Clavero, R.; Coignet, G.; Consolandi, C.; Contin, A.; Corti, C.; Coste, B.; Cui, Z.; Dai, M.; Delgado, C.; Della Torre, S.; Demirköz, M. B.; Derome, L.; Di Falco, S.; Di Masso, L.; Dimiccoli, F.; Díaz, C.; von Doetinchem, P.; Du, W. J.; Duranti, M.; D'Urso, D.; Eline, A.; Eppling, F. J.; Eronen, T.; Fan, Y. Y.; Farnesini, L.; Feng, J.; Fiandrini, E.; Fiasson, A.; Finch, E.; Fisher, P.; Galaktionov, Y.; Gallucci, G.; García, B.; García-López, R.; Gast, H.; Gebauer, I.; Gervasi, M.; Ghelfi, A.; Gillard, W.; Giovacchini, F.; Goglov, P.; Gong, J.; Goy, C.; Grabski, V.; Grandi, D.; Graziani, M.; Guandalini, C.; Guerri, I.; Guo, K. H.; Habiby, M.; Haino, S.; Han, K. C.; He, Z. H.; Heil, M.; Hoffman, J.; Hsieh, T. H.; Huang, Z. C.; Huh, C.; Incagli, M.; Ionica, M.; Jang, W. Y.; Jinchi, H.; Kanishev, K.; Kim, G. N.; Kim, K. S.; Kirn, Th.; Kossakowski, R.; Kounina, O.; Kounine, A.; Koutsenko, V.; Krafczyk, M. S.; Kunz, S.; La Vacca, G.; Laudi, E.; Laurenti, G.; Lazzizzera, I.; Lebedev, A.; Lee, H. T.; Lee, S. C.; Leluc, C.; Li, H. L.; Li, J. Q.; Li, Q.; Li, Q.; Li, T. X.; Li, W.; Li, Y.; Li, Z. H.; Li, Z. Y.; Lim, S.; Lin, C. H.; Lipari, P.; Lippert, T.; Liu, D.; Liu, H.; Lomtadze, T.; Lu, M. J.; Lu, Y. S.; Luebelsmeyer, K.; Luo, F.; Luo, J. Z.; Lv, S. S.; Majka, R.; Malinin, A.; Mañá, C.; Marín, J.; Martin, T.; Martínez, G.; Masi, N.; Maurin, D.; Menchaca-Rocha, A.; Meng, Q.; Mo, D. C.; Morescalchi, L.; Mott, P.; Müller, M.; Ni, J. Q.; Nikonov, N.; Nozzoli, F.; Nunes, P.; Obermeier, A.; Oliva, A.; Orcinha, M.; Palmonari, F.; Palomares, C.; Paniccia, M.; Papi, A.; Pedreschi, E.; Pensotti, S.; Pereira, R.; Pilo, F.; Piluso, A.; Pizzolotto, C.; Plyaskin, V.; Pohl, M.; Poireau, V.; Postaci, E.; Putze, A.; Quadrani, L.; Qi, X. M.; Rancoita, P. G.; Rapin, D.; Ricol, J. S.; Rodríguez, I.; Rosier-Lees, S.; Rozhkov, A.; Rozza, D.; Sagdeev, R.; Sandweiss, J.; Saouter, P.; Sbarra, C.; Schael, S.; Schmidt, S. M.; Schuckardt, D.; von Dratzig, A. Schulz; Schwering, G.; Scolieri, G.; Seo, E. S.; Shan, B. S.; Shan, Y. H.; Shi, J. Y.; Shi, X. Y.; Shi, Y. M.; Siedenburg, T.; Son, D.; Spada, F.; Spinella, F.; Sun, W.; Sun, W. H.; Tacconi, M.; Tang, C. P.; Tang, X. W.; Tang, Z. C.; Tao, L.; Tescaro, D.; Ting, Samuel C. C.; Ting, S. M.; Tomassetti, N.; Torsti, J.; Türkoǧlu, C.; Urban, T.; Vagelli, V.; Valente, E.; Vannini, C.; Valtonen, E.; Vaurynovich, S.; Vecchi, M.; Velasco, M.; Vialle, J. P.; Wang, L. Q.; Wang, Q. L.; Wang, R. S.; Wang, X.; Wang, Z. X.; Weng, Z. L.; Whitman, K.; Wienkenhöver, J.; Wu, H.; Xia, X.; Xie, M.; Xie, S.; Xiong, R. Q.; Xin, G. M.; Xu, N. S.; Xu, W.; Yan, Q.; Yang, J.; Yang, M.; Ye, Q. H.; Yi, H.; Yu, Y. J.; Yu, Z. Q.; Zeissler, S.; Zhang, J. H.; Zhang, M. T.; Zhang, X. B.; Zhang, Z.; Zheng, Z. M.; Zhuang, H. L.; Zhukov, V.; Zichichi, A.; Zimmermann, N.; Zuccon, P.; Zurbach, C.; AMS Collaboration</p> <p>2014-09-01</p> <p>Precision measurements by the Alpha Magnetic Spectrometer on the International Space Station of the primary cosmic-ray <span class="hlt">electron</span> <span class="hlt">flux</span> in the range 0.5 to 700 GeV and the positron <span class="hlt">flux</span> in the range 0.5 to 500 GeV are presented. The <span class="hlt">electron</span> <span class="hlt">flux</span> and the positron <span class="hlt">flux</span> each require a description beyond a single power-law spectrum. Both the <span class="hlt">electron</span> <span class="hlt">flux</span> and the positron <span class="hlt">flux</span> change their behavior at ˜30 GeV but the <span class="hlt">fluxes</span> are significantly different in their magnitude and energy dependence. Between 20 and 200 GeV the positron spectral index is significantly harder than the <span class="hlt">electron</span> spectral index. The determination of the differing behavior of the spectral indices versus energy is a new observation and provides important information on the origins of cosmic-ray <span class="hlt">electrons</span> and positrons.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFMSM21A2565C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFMSM21A2565C"><span>Statistical analysis of low-energy <span class="hlt">electron</span> <span class="hlt">fluxes</span> in the radiation belt: ERG LEP-e measurements</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Chang, T. F.; Chiang, C. Y.; Tam, S. W. Y.; Syugu, W. J.; Kazama, Y.; Wang, B. J.; Wang, S. Y.; Hori, T.; Yoshizumi, M.; Shinohara, I.</p> <p>2017-12-01</p> <p>The Exploration of energization and Radiation in Geospace (ERG) satellite, which is led by Institute of Space and Astronautical Science (ISAS), Japan Aerospace Exploration Agency (JAXA), has observed the Earth's radiation belts for several months. Through years of efforts, Taiwan team successfully delivered the low-energy particle experiments - <span class="hlt">electron</span> analyzer (LEP-e) for deployment on the ERG satellite. In Taiwan, the project is led by Academia Sinica Institute of Astronomy and Astrophysics (ASIAA) in partnership with National Cheng Kung University (NCKU). The LEP-e instrument measures a 3-D velocity distribution function of low energy <span class="hlt">electrons</span> ranging from 20 eV to 19 keV. We provide an overview of <span class="hlt">electron</span> <span class="hlt">fluxes</span> within the radiation belts using the LEP-e instrument data obtained in the past months. The L-shell plots are made upon 100 eV, 1 keV and 10 keV, respectively, to display the <span class="hlt">electron</span> <span class="hlt">flux</span> in various L-shells measured by the ERG satellite. The enhancement of the <span class="hlt">electron</span> <span class="hlt">fluxes</span> is found to show correspondence with the increase of ring current intensity. These <span class="hlt">electrons</span> are found to migrate inwards as the ring current increases. We also investigate the 3-D distribution of the <span class="hlt">electron</span> <span class="hlt">fluxes</span> and discuss the contribution of the energetic <span class="hlt">electrons</span> to the ring current.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li class="active"><span>7</span></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_7 --> <div id="page_8" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li class="active"><span>8</span></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="141"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1260266-measurement-neutrino-flux-from-neutrino-electron-elastic-scattering','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1260266-measurement-neutrino-flux-from-neutrino-electron-elastic-scattering"><span>Measurement of neutrino <span class="hlt">flux</span> from neutrino-<span class="hlt">electron</span> elastic scattering</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Park, J.; Aliaga, L.; Altinok, O.; ...</p> <p>2016-06-10</p> <p>Muon-neutrino elastic scattering on <span class="hlt">electrons</span> is an observable neutrino process whose cross section is precisely known. Consequently, a measurement of this process in an accelerator-based ν μ beam can improve the knowledge of the absolute neutrino <span class="hlt">flux</span> impinging upon the detector; typically this knowledge is limited to ~10% due to uncertainties in hadron production and focusing. We also isolated a sample of 135±17 neutrino-<span class="hlt">electron</span> elastic scattering candidates in the segmented scintillator detector of MINERvA, after subtracting backgrounds and correcting for efficiency. We show how this sample can be used to reduce the total uncertainty on the NuMI ν μ fluxmore » from 9% to 6%. Finally, our measurement provides a <span class="hlt">flux</span> constraint that is useful to other experiments using the NuMI beam, and this technique is applicable to future neutrino beams operating at multi-GeV energies.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFMSH32A..04S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFMSH32A..04S"><span>Control Mechanisms of the <span class="hlt">Electron</span> Heat <span class="hlt">Flux</span> in the Solar Wind: Observations in Comparison to Numerical Simulations</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Stverak, S.; Hellinger, P.; Landi, S.; Travnicek, P. M.; Maksimovic, M.</p> <p>2017-12-01</p> <p>Recent understanding of the heat transport and dissipation in the expanding solar wind propose number of complex control mechanisms down to the <span class="hlt">electron</span> kinetic scales. We investigate the evolution of <span class="hlt">electron</span> heat <span class="hlt">flux</span> properties and constraints along the expansion using in situ observations from Helios spacecraft in comparison to numerical kinetic simulations. In particular we focus on the roles of Coulomb collisions and wave-particle interactions in shaping the <span class="hlt">electron</span> velocity distribution functions and thus controlling the heat transported by the <span class="hlt">electron</span> heat <span class="hlt">flux</span>. We show the general evolution of the <span class="hlt">electron</span> heat <span class="hlt">flux</span> to be driven namely by the Coulomb collisions. Locally we demonstrate the wave-particle interactions related to the kinetic plasma instabilities to be providing effective constraints in case of extreme heat <span class="hlt">flux</span> levels.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25279617','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25279617"><span><span class="hlt">Electron</span> and positron <span class="hlt">fluxes</span> in primary cosmic rays measured with the alpha magnetic spectrometer on the international space station.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Aguilar, M; Aisa, D; Alvino, A; Ambrosi, G; Andeen, K; Arruda, L; Attig, N; Azzarello, P; Bachlechner, A; Barao, F; Barrau, A; Barrin, L; Bartoloni, A; Basara, L; Battarbee, M; Battiston, R; Bazo, J; Becker, U; Behlmann, M; Beischer, B; Berdugo, J; Bertucci, B; Bigongiari, G; Bindi, V; Bizzaglia, S; Bizzarri, M; Boella, G; de Boer, W; Bollweg, K; Bonnivard, V; Borgia, B; Borsini, S; Boschini, M J; Bourquin, M; Burger, J; Cadoux, F; Cai, X D; Capell, M; Caroff, S; Casaus, J; Cascioli, V; Castellini, G; Cernuda, I; Cervelli, F; Chae, M J; Chang, Y H; Chen, A I; Chen, H; Cheng, G M; Chen, H S; Cheng, L; Chikanian, A; Chou, H Y; Choumilov, E; Choutko, V; Chung, C H; Clark, C; Clavero, R; Coignet, G; Consolandi, C; Contin, A; Corti, C; Coste, B; Cui, Z; Dai, M; Delgado, C; Della Torre, S; Demirköz, M B; Derome, L; Di Falco, S; Di Masso, L; Dimiccoli, F; Díaz, C; von Doetinchem, P; Du, W J; Duranti, M; D'Urso, D; Eline, A; Eppling, F J; Eronen, T; Fan, Y Y; Farnesini, L; Feng, J; Fiandrini, E; Fiasson, A; Finch, E; Fisher, P; Galaktionov, Y; Gallucci, G; García, B; García-López, R; Gast, H; Gebauer, I; Gervasi, M; Ghelfi, A; Gillard, W; Giovacchini, F; Goglov, P; Gong, J; Goy, C; Grabski, V; Grandi, D; Graziani, M; Guandalini, C; Guerri, I; Guo, K H; Habiby, M; Haino, S; Han, K C; He, Z H; Heil, M; Hoffman, J; Hsieh, T H; Huang, Z C; Huh, C; Incagli, M; Ionica, M; Jang, W Y; Jinchi, H; Kanishev, K; Kim, G N; Kim, K S; Kirn, Th; Kossakowski, R; Kounina, O; Kounine, A; Koutsenko, V; Krafczyk, M S; Kunz, S; La Vacca, G; Laudi, E; Laurenti, G; Lazzizzera, I; Lebedev, A; Lee, H T; Lee, S C; Leluc, C; Li, H L; Li, J Q; Li, Q; Li, Q; Li, T X; Li, W; Li, Y; Li, Z H; Li, Z Y; Lim, S; Lin, C H; Lipari, P; Lippert, T; Liu, D; Liu, H; Lomtadze, T; Lu, M J; Lu, Y S; Luebelsmeyer, K; Luo, F; Luo, J Z; Lv, S S; Majka, R; Malinin, A; Mañá, C; Marín, J; Martin, T; Martínez, G; Masi, N; Maurin, D; Menchaca-Rocha, A; Meng, Q; Mo, D C; Morescalchi, L; Mott, P; Müller, M; Ni, J Q; Nikonov, N; Nozzoli, F; Nunes, P; Obermeier, A; Oliva, A; Orcinha, M; Palmonari, F; Palomares, C; Paniccia, M; Papi, A; Pedreschi, E; Pensotti, S; Pereira, R; Pilo, F; Piluso, A; Pizzolotto, C; Plyaskin, V; Pohl, M; Poireau, V; Postaci, E; Putze, A; Quadrani, L; Qi, X M; Rancoita, P G; Rapin, D; Ricol, J S; Rodríguez, I; Rosier-Lees, S; Rozhkov, A; Rozza, D; Sagdeev, R; Sandweiss, J; Saouter, P; Sbarra, C; Schael, S; Schmidt, S M; Schuckardt, D; Schulz von Dratzig, A; Schwering, G; Scolieri, G; Seo, E S; Shan, B S; Shan, Y H; Shi, J Y; Shi, X Y; Shi, Y M; Siedenburg, T; Son, D; Spada, F; Spinella, F; Sun, W; Sun, W H; Tacconi, M; Tang, C P; Tang, X W; Tang, Z C; Tao, L; Tescaro, D; Ting, Samuel C C; Ting, S M; Tomassetti, N; Torsti, J; Türkoğlu, C; Urban, T; Vagelli, V; Valente, E; Vannini, C; Valtonen, E; Vaurynovich, S; Vecchi, M; Velasco, M; Vialle, J P; Wang, L Q; Wang, Q L; Wang, R S; Wang, X; Wang, Z X; Weng, Z L; Whitman, K; Wienkenhöver, J; Wu, H; Xia, X; Xie, M; Xie, S; Xiong, R Q; Xin, G M; Xu, N S; Xu, W; Yan, Q; Yang, J; Yang, M; Ye, Q H; Yi, H; Yu, Y J; Yu, Z Q; Zeissler, S; Zhang, J H; Zhang, M T; Zhang, X B; Zhang, Z; Zheng, Z M; Zhuang, H L; Zhukov, V; Zichichi, A; Zimmermann, N; Zuccon, P; Zurbach, C</p> <p>2014-09-19</p> <p>Precision measurements by the Alpha Magnetic Spectrometer on the International Space Station of the primary cosmic-ray <span class="hlt">electron</span> <span class="hlt">flux</span> in the range 0.5 to 700 GeV and the positron <span class="hlt">flux</span> in the range 0.5 to 500 GeV are presented. The <span class="hlt">electron</span> <span class="hlt">flux</span> and the positron <span class="hlt">flux</span> each require a description beyond a single power-law spectrum. Both the <span class="hlt">electron</span> <span class="hlt">flux</span> and the positron <span class="hlt">flux</span> change their behavior at ∼30  GeV but the <span class="hlt">fluxes</span> are significantly different in their magnitude and energy dependence. Between 20 and 200 GeV the positron spectral index is significantly harder than the <span class="hlt">electron</span> spectral index. The determination of the differing behavior of the spectral indices versus energy is a new observation and provides important information on the origins of cosmic-ray <span class="hlt">electrons</span> and positrons.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013ATel.5001....1D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013ATel.5001....1D"><span>Fermi-<span class="hlt">LAT</span> detection of a gamma-ray flaring source in the vicinity of PKS 0507+17</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>D'Ammando, F.; Orienti, M.</p> <p>2013-04-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed an increasing gamma-ray <span class="hlt">flux</span> from a source positionally consistent with PKS 0507+17 (also known as 2FGL J0509.9+1802, Nolan et al. 2012, ApJS, 199, 31; R.A.= 05h10m02.3691s, Dec.= +18d00m41.582s, J2000.0, Johnston et al. 1995, AJ, 110, 880), a flat spectrum radio quasar at redshift z = 0.416 (Perlman et al.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013ATel.4706....1D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013ATel.4706....1D"><span>Fermi-<span class="hlt">LAT</span> detection of a gamma-ray flare from the high-z blazar PKS 2149-306</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>D'Ammando, F.; Orienti, M.</p> <p>2013-01-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed an increasing gamma-ray <span class="hlt">flux</span> from a source positionally consistent with PKS 2149-306 (also known as 2FGL J2151.5-3021, Nolan et al. 2012, ApJS, 199, 31; R.A.= 21h51m55.5239s, Dec.= -30d27m53.697s, J2000.0, Johnston et al. 1995, AJ, 110, 880), a flat spectrum radio quasar at redshift z = 2.345 (Wilkes 1986, MNRAS, 218, 331).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016ATel.8533....1C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016ATel.8533....1C"><span>Fermi-<span class="hlt">LAT</span> detection of a GeV gamma-ray flare from the blazar PKS 1313-333</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ciprini, Stefano</p> <p>2016-01-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray <span class="hlt">flux</span> from a source positionally consistent with the flat spectrum radio quasar PKS 1313-333 (also known as TXS 1313-333, OP -322, 2EG J1314-3430 and 3FGL J1316.0-3338), with radio counterpart position R.A.: 199.033275 deg, Dec.: -33.64977 deg, (J2000.0, Johnston et al. 1995, AJ, 110, 880) and with redshift z=1.210 (Jauncey et al. 1982, AJ, 87, 763).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20110005617','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20110005617"><span>Fermi-<span class="hlt">LAT</span> Gamma-Ray Bursts and Insights from Swift</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Racusin, Judith L.</p> <p>2010-01-01</p> <p>A new revolution in Gamma-ray Burst (GRB) observations and theory has begun over the last two years since the launch of the Fermi Gamma-ray Space Telescope. The new window into high energy gamma-rays opened by the Fermi-Large Area Telescope (<span class="hlt">LAT</span>) is providing insight into prompt emission mechanisms and possibly also afterglow physics. The <span class="hlt">LAT</span> detected GRBs appear to be a new unique subset of extremely energetic and bright bursts compared to the large sample detected by Swift over the last 6 years. In this talk, I will discuss the context and recent discoveries from these <span class="hlt">LAT</span> GRBs and the large database of broadband observations collected by the Swift X-ray Telescope (XRT) and UV/Optical Telescope (UVOT). Through comparisons between the GRBs detected by Swift-BAT, G8M, and <span class="hlt">LAT</span>, we can learn about the unique characteristics, physical differences, and the relationships between each population. These population characteristics provide insight into the different physical parameters that contribute to the diversity of observational GRB properties.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22617489-study-decoherence-system-superconducting-flux-qubits-interacting-ensemble-electrons','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22617489-study-decoherence-system-superconducting-flux-qubits-interacting-ensemble-electrons"><span>Study of decoherence in a system of superconducting <span class="hlt">flux</span>-qubits interacting with an ensemble of <span class="hlt">electrons</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Reboiro, M., E-mail: reboiro@fisica.unlp.edu.ar; Civitarese, O., E-mail: osvaldo.civitarese@fisica.unlp.edu.ar; Ramírez, R.</p> <p>2017-03-15</p> <p>The degree of coherence in a hybrid system composed of superconducting <span class="hlt">flux</span>-qubits and an <span class="hlt">electron</span> ensemble is analysed. Both, the interactions among the <span class="hlt">electrons</span> and among the superconducting <span class="hlt">flux</span>-qubits are taken into account. The time evolution of the hybrid system is solved exactly, and discussed in terms of the reduced density matrix of each subsystem. It is seen that the inclusion of a line width, for the <span class="hlt">electrons</span> and for the superconducting <span class="hlt">flux</span>-qubits, influences the pattern of spin-squeezing and the coherence of the superconducting <span class="hlt">flux</span> qubits. - Highlights: • The degree of coherence in a hybrid system, composed of superconductingmore » <span class="hlt">flux</span> qubits and an <span class="hlt">electron</span> ensemble, is analysed. • The time evolution of the hybrid system is solved exactly and discussed in terms of the reduced density matrix of each subsystem. • It is shown that the initial state of the system evolves to a stationary squeezed state.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017ATel10905....1G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017ATel10905....1G"><span>Fermi <span class="hlt">LAT</span> detection of a GeV gamma-ray flare from blazar CGRaBS J0809+5341 (87GB 080551.6+535010)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gasparrini, Dario</p> <p>2017-10-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), one of two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray emission from a source positionally consistent with the flat spectrum radio quasar CGRaBS J0809+5341 (also known as 87GB 080551.6+535010, BZQ J0809+5341 and 3FGL J0809.5+5342) with radio coordinates (J2000) R.A.: 122.4238862 deg, Dec.: 53.6903033 deg (Petrov et al. 2011, AJ, 142, 89). This blazar has a redshift z = 2.133 (Healey et al. 2008, ApJS, 175, 97). Preliminary analysis indicates that on 2017 October 26, CGRaBS J0809+5341 was in a high state with a daily averaged gamma-ray <span class="hlt">flux</span> (E > 100 MeV) of (0.23+/-0.15) X 10^-6 photons cm^-2 s^-1 (statistical uncertainty only), about 20 times greater than its four-year average <span class="hlt">flux</span> reported in the third Fermi-<span class="hlt">LAT</span> source catalog (3FGL, Acero et al. 2015, ApJS, 218, 23). Because Fermi operates in an all-sky scanning mode, regular gamma-ray monitoring of this source will continue.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1402660-empirical-predictive-models-daily-relativistic-electron-flux-geostationary-orbit-multiple-regression-analysis','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1402660-empirical-predictive-models-daily-relativistic-electron-flux-geostationary-orbit-multiple-regression-analysis"><span>Empirical predictive models of daily relativistic <span class="hlt">electron</span> <span class="hlt">flux</span> at geostationary orbit: Multiple regression analysis</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Simms, Laura E.; Engebretson, Mark J.; Pilipenko, Viacheslav; ...</p> <p>2016-04-07</p> <p>The daily maximum relativistic <span class="hlt">electron</span> <span class="hlt">flux</span> at geostationary orbit can be predicted well with a set of daily averaged predictor variables including previous day's <span class="hlt">flux</span>, seed <span class="hlt">electron</span> <span class="hlt">flux</span>, solar wind velocity and number density, AE index, IMF Bz, Dst, and ULF and VLF wave power. As predictor variables are intercorrelated, we used multiple regression analyses to determine which are the most predictive of <span class="hlt">flux</span> when other variables are controlled. Empirical models produced from regressions of <span class="hlt">flux</span> on measured predictors from 1 day previous were reasonably effective at predicting novel observations. Adding previous <span class="hlt">flux</span> to the parameter set improves the predictionmore » of the peak of the increases but delays its anticipation of an event. Previous day's solar wind number density and velocity, AE index, and ULF wave activity are the most significant explanatory variables; however, the AE index, measuring substorm processes, shows a negative correlation with <span class="hlt">flux</span> when other parameters are controlled. This may be due to the triggering of electromagnetic ion cyclotron waves by substorms that cause <span class="hlt">electron</span> precipitation. VLF waves show lower, but significant, influence. The combined effect of ULF and VLF waves shows a synergistic interaction, where each increases the influence of the other on <span class="hlt">flux</span> enhancement. Correlations between observations and predictions for this 1 day lag model ranged from 0.71 to 0.89 (average: 0.78). Furthermore, a path analysis of correlations between predictors suggests that solar wind and IMF parameters affect <span class="hlt">flux</span> through intermediate processes such as ring current ( Dst), AE, and wave activity.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1402660','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1402660"><span>Empirical predictive models of daily relativistic <span class="hlt">electron</span> <span class="hlt">flux</span> at geostationary orbit: Multiple regression analysis</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Simms, Laura E.; Engebretson, Mark J.; Pilipenko, Viacheslav</p> <p></p> <p>The daily maximum relativistic <span class="hlt">electron</span> <span class="hlt">flux</span> at geostationary orbit can be predicted well with a set of daily averaged predictor variables including previous day's <span class="hlt">flux</span>, seed <span class="hlt">electron</span> <span class="hlt">flux</span>, solar wind velocity and number density, AE index, IMF Bz, Dst, and ULF and VLF wave power. As predictor variables are intercorrelated, we used multiple regression analyses to determine which are the most predictive of <span class="hlt">flux</span> when other variables are controlled. Empirical models produced from regressions of <span class="hlt">flux</span> on measured predictors from 1 day previous were reasonably effective at predicting novel observations. Adding previous <span class="hlt">flux</span> to the parameter set improves the predictionmore » of the peak of the increases but delays its anticipation of an event. Previous day's solar wind number density and velocity, AE index, and ULF wave activity are the most significant explanatory variables; however, the AE index, measuring substorm processes, shows a negative correlation with <span class="hlt">flux</span> when other parameters are controlled. This may be due to the triggering of electromagnetic ion cyclotron waves by substorms that cause <span class="hlt">electron</span> precipitation. VLF waves show lower, but significant, influence. The combined effect of ULF and VLF waves shows a synergistic interaction, where each increases the influence of the other on <span class="hlt">flux</span> enhancement. Correlations between observations and predictions for this 1 day lag model ranged from 0.71 to 0.89 (average: 0.78). Furthermore, a path analysis of correlations between predictors suggests that solar wind and IMF parameters affect <span class="hlt">flux</span> through intermediate processes such as ring current ( Dst), AE, and wave activity.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018PhRvL.120g5101Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018PhRvL.120g5101Z"><span>Evidence for Secondary <span class="hlt">Flux</span> Rope Generated by the <span class="hlt">Electron</span> Kelvin-Helmholtz Instability in a Magnetic Reconnection Diffusion Region</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zhong, Z. H.; Tang, R. X.; Zhou, M.; Deng, X. H.; Pang, Y.; Paterson, W. R.; Giles, B. L.; Burch, J. L.; Tobert, R. B.; Ergun, R. E.; Khotyaintsev, Y. V.; Lindquist, P.-A.</p> <p>2018-02-01</p> <p>Secondary <span class="hlt">flux</span> ropes are suggested to play important roles in energy dissipation and particle acceleration during magnetic reconnection. However, their generation mechanism is not fully understood. In this Letter, we present the first direct evidence that a secondary <span class="hlt">flux</span> rope was generated due to the evolution of an <span class="hlt">electron</span> vortex, which was driven by the <span class="hlt">electron</span> Kelvin-Helmholtz instability in an ion diffusion region as observed by the Magnetospheric Multiscale mission. The subion scale (less than the ion inertial length) <span class="hlt">flux</span> rope was embedded within the <span class="hlt">electron</span> vortex, which contained a secondary <span class="hlt">electron</span> diffusion region at the trailing edge of the <span class="hlt">flux</span> rope. We propose that intense <span class="hlt">electron</span> shear flow produced by reconnection generated the <span class="hlt">electron</span> Kelvin-Helmholtz vortex, which induced a secondary reconnection in the exhaust of the primary X line and then led to the formation of the <span class="hlt">flux</span> rope. This result strongly suggests that secondary <span class="hlt">electron</span> Kelvin-Helmholtz instability is important for reconnection dynamics.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29542938','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29542938"><span>Evidence for Secondary <span class="hlt">Flux</span> Rope Generated by the <span class="hlt">Electron</span> Kelvin-Helmholtz Instability in a Magnetic Reconnection Diffusion Region.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Zhong, Z H; Tang, R X; Zhou, M; Deng, X H; Pang, Y; Paterson, W R; Giles, B L; Burch, J L; Tobert, R B; Ergun, R E; Khotyaintsev, Y V; Lindquist, P-A</p> <p>2018-02-16</p> <p>Secondary <span class="hlt">flux</span> ropes are suggested to play important roles in energy dissipation and particle acceleration during magnetic reconnection. However, their generation mechanism is not fully understood. In this Letter, we present the first direct evidence that a secondary <span class="hlt">flux</span> rope was generated due to the evolution of an <span class="hlt">electron</span> vortex, which was driven by the <span class="hlt">electron</span> Kelvin-Helmholtz instability in an ion diffusion region as observed by the Magnetospheric Multiscale mission. The subion scale (less than the ion inertial length) <span class="hlt">flux</span> rope was embedded within the <span class="hlt">electron</span> vortex, which contained a secondary <span class="hlt">electron</span> diffusion region at the trailing edge of the <span class="hlt">flux</span> rope. We propose that intense <span class="hlt">electron</span> shear flow produced by reconnection generated the <span class="hlt">electron</span> Kelvin-Helmholtz vortex, which induced a secondary reconnection in the exhaust of the primary X line and then led to the formation of the <span class="hlt">flux</span> rope. This result strongly suggests that secondary <span class="hlt">electron</span> Kelvin-Helmholtz instability is important for reconnection dynamics.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19890056315&hterms=dropout&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Ddropout','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19890056315&hterms=dropout&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Ddropout"><span><span class="hlt">Electron</span> heat <span class="hlt">flux</span> dropouts in the solar wind - Evidence for interplanetary magnetic field reconnection?</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Mccomas, D. J.; Gosling, J. T.; Phillips, J. L.; Bame, S. J.; Luhmann, J. G.; Smith, E. J.</p> <p>1989-01-01</p> <p>An examination of ISEE-3 data from 1978 reveal 25 <span class="hlt">electron</span> heat <span class="hlt">flux</span> dropout events ranging in duration from 20 min to over 11 hours. The heat <span class="hlt">flux</span> dropouts are found to occur in association with high plasma densities, low plasma velocities, low ion and <span class="hlt">electron</span> temperatures, and low magnetic field magnitudes. It is suggested that the heat <span class="hlt">flux</span> dropout intervals may indicate that the spacecraft is sampling plasma regimes which are magnetically disconnected from the sun and instead are connected to the outer heliosphere at both ends.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22016216-search-gamma-ray-emission-from-ray-selected-seyfert-galaxies-fermi-lat','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22016216-search-gamma-ray-emission-from-ray-selected-seyfert-galaxies-fermi-lat"><span>SEARCH FOR GAMMA-RAY EMISSION FROM X-RAY-SELECTED SEYFERT GALAXIES WITH FERMI-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Ackermann, M.; Ajello, M.; Allafort, A.</p> <p></p> <p>We report on a systematic investigation of the {gamma}-ray properties of 120 hard X-ray-selected Seyfert galaxies classified as 'radio-quiet' objects, utilizing the three-year accumulation of Fermi Large Area Telescope (<span class="hlt">LAT</span>) data. Our sample of Seyfert galaxies is selected using the Swift Burst Alert Telescope 58 month catalog, restricting the analysis to the bright sources with average hard X-ray <span class="hlt">fluxes</span> F{sub 14-195keV} {>=} 2.5 Multiplication-Sign 10{sup -11} erg cm{sup -2} s{sup -1} at high Galactic latitudes (|b| > 10 Degree-Sign ). In order to remove 'radio-loud' objects from the sample, we use the 'hard X-ray radio loudness parameter', R{sub rX}, definedmore » as the ratio of the total 1.4 GHz radio to 14-195 keV hard X-ray energy <span class="hlt">fluxes</span>. Among 120 X-ray bright Seyfert galaxies with R{sub rX} <10{sup -4}, we did not find a statistically significant {gamma}-ray excess (TS > 25) positionally coincident with any target Seyferts, with possible exceptions of ESO 323-G077 and NGC 6814. The mean value of the 95% confidence level {gamma}-ray upper limit for the integrated photon <span class="hlt">flux</span> above 100 MeV from the analyzed Seyferts is {approx_equal} 4 Multiplication-Sign 10{sup -9} photons cm{sup -2} s{sup -1} , and the upper limits derived for several objects reach {approx_equal} 1 Multiplication-Sign 10{sup -9} photons cm{sup -2} s{sup -1} . Our results indicate that no prominent {gamma}-ray emission component related to active galactic nucleus activity is present in the spectra of Seyferts around GeV energies. The Fermi-<span class="hlt">LAT</span> upper limits derived for our sample probe the ratio of {gamma}-ray to X-ray luminosities L{sub {gamma}}/L{sub X} < 0.1, and even <0.01 in some cases. The obtained results impose novel constraints on the models for high-energy radiation of 'radio-quiet' Seyfert galaxies.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1414121-critical-role-electron-heat-flux-bohm-criterion','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1414121-critical-role-electron-heat-flux-bohm-criterion"><span>Critical role of <span class="hlt">electron</span> heat <span class="hlt">flux</span> on Bohm criterion</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Tang, Xianzhu; Guo, Zehua</p> <p>2016-12-05</p> <p>Bohm criterion, originally derived for an isothermal-<span class="hlt">electron</span> and cold-ion plasma, is often used as a rule of thumb for more general plasmas. Here, we establish a more precise determination of the Bohm criterion that are quantitatively useful for understanding and modeling collisional plasmas that still have collisional mean-free-path much greater than plasma Debye length. Specifically, it is shown that <span class="hlt">electron</span> heat <span class="hlt">flux</span>, rather than the isothermal <span class="hlt">electron</span> assumption, is what sets the Bohm speed to bemore » $$\\sqrt{k_B(T_e||+3T_i||)/m_i}$$ with T e,i∥ the <span class="hlt">electron</span> and ion parallel temperature at the sheath entrance and m i the ion mass.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016PhPl...23l0701T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016PhPl...23l0701T"><span>Critical role of <span class="hlt">electron</span> heat <span class="hlt">flux</span> on Bohm criterion</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Tang, Xian-Zhu; Guo, Zehua</p> <p>2016-12-01</p> <p>Bohm criterion, originally derived for an isothermal-<span class="hlt">electron</span> and cold-ion plasma, is often used as a rule of thumb for more general plasmas. Here, we establish a more precise determination of the Bohm criterion that are quantitatively useful for understanding and modeling collisional plasmas that still have collisional mean-free-path much greater than plasma Debye length. Specifically, it is shown that <span class="hlt">electron</span> heat <span class="hlt">flux</span>, rather than the isothermal <span class="hlt">electron</span> assumption, is what sets the Bohm speed to be √{ k B ( T e ∥ + 3 T i ∥ ) / m i } with T e , i ∥ the <span class="hlt">electron</span> and ion parallel temperature at the sheath entrance and mi the ion mass.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1193436','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1193436"><span>An empirical model of <span class="hlt">electron</span> and ion <span class="hlt">fluxes</span> derived from observations at geosynchronous orbit</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Denton, M. H.; Thomsen, M. F.; Jordanova, V. K.</p> <p></p> <p>Knowledge of the plasma <span class="hlt">fluxes</span> at geosynchronous orbit is important to both scientific and operational investigations. We present a new empirical model of the ion <span class="hlt">flux</span> and the <span class="hlt">electron</span> <span class="hlt">flux</span> at geosynchronous orbit (GEO) in the energy range ~1 eV to ~40 keV. The model is based on a total of 82 satellite-years of observations from the Magnetospheric Plasma Analyzer instruments on Los Alamos National Laboratory satellites at GEO. These data are assigned to a fixed grid of 24 local-times and 40 energies, at all possible values of Kp. Bi-linear interpolation is used between grid points to provide the ionmore » <span class="hlt">flux</span> and the <span class="hlt">electron</span> <span class="hlt">flux</span> values at any energy and local-time, and for given values of geomagnetic activity (proxied by the 3-hour Kp index), and also for given values of solar activity (proxied by the daily F10.7 index). Initial comparison of the <span class="hlt">electron</span> <span class="hlt">flux</span> from the model with data from a Compact Environmental Anomaly Sensor II (CEASE-II), also located at geosynchronous orbit, indicate a good match during both quiet and disturbed periods. The model is available for distribution as a FORTRAN code that can be modified to suit user-requirements.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1193436-empirical-model-electron-ion-fluxes-derived-from-observations-geosynchronous-orbit','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1193436-empirical-model-electron-ion-fluxes-derived-from-observations-geosynchronous-orbit"><span>An empirical model of <span class="hlt">electron</span> and ion <span class="hlt">fluxes</span> derived from observations at geosynchronous orbit</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Denton, M. H.; Thomsen, M. F.; Jordanova, V. K.; ...</p> <p>2015-04-01</p> <p>Knowledge of the plasma <span class="hlt">fluxes</span> at geosynchronous orbit is important to both scientific and operational investigations. We present a new empirical model of the ion <span class="hlt">flux</span> and the <span class="hlt">electron</span> <span class="hlt">flux</span> at geosynchronous orbit (GEO) in the energy range ~1 eV to ~40 keV. The model is based on a total of 82 satellite-years of observations from the Magnetospheric Plasma Analyzer instruments on Los Alamos National Laboratory satellites at GEO. These data are assigned to a fixed grid of 24 local-times and 40 energies, at all possible values of Kp. Bi-linear interpolation is used between grid points to provide the ionmore » <span class="hlt">flux</span> and the <span class="hlt">electron</span> <span class="hlt">flux</span> values at any energy and local-time, and for given values of geomagnetic activity (proxied by the 3-hour Kp index), and also for given values of solar activity (proxied by the daily F10.7 index). Initial comparison of the <span class="hlt">electron</span> <span class="hlt">flux</span> from the model with data from a Compact Environmental Anomaly Sensor II (CEASE-II), also located at geosynchronous orbit, indicate a good match during both quiet and disturbed periods. The model is available for distribution as a FORTRAN code that can be modified to suit user-requirements.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1402605','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1402605"><span>Relativistic <span class="hlt">electron</span> microbursts and variations in trapped MeV <span class="hlt">electron</span> <span class="hlt">fluxes</span> during the 8-9 October 2012 storm: SAMPEX and Van Allen Probes observations</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Kurita, Satoshi; Miyoshi, Yoshizumi; Blake, J. Bernard</p> <p>2016-03-06</p> <p>It has been suggested that whistler mode chorus is responsible for both acceleration of MeV <span class="hlt">electrons</span> and relativistic <span class="hlt">electron</span> microbursts through resonant wave-particle interactions. Relativistic <span class="hlt">electron</span> microbursts have been considered as an important loss mechanism of radiation belt <span class="hlt">electrons</span>. Here in this paper we report on the observations of relativistic <span class="hlt">electron</span> microbursts and <span class="hlt">flux</span> variations of trapped MeV <span class="hlt">electrons</span> during the 8–9 October 2012 storm, using the SAMPEX and Van Allen Probes satellites. Observations by the satellites show that relativistic <span class="hlt">electron</span> microbursts correlate well with the rapid enhancement of trapped MeV <span class="hlt">electron</span> <span class="hlt">fluxes</span> by chorus wave-particle interactions, indicating that accelerationmore » by chorus is much more efficient than losses by microbursts during the storm. It is also revealed that the strong chorus wave activity without relativistic <span class="hlt">electron</span> microbursts does not lead to significant <span class="hlt">flux</span> variations of relativistic <span class="hlt">electrons</span>. Thus, effective acceleration of relativistic <span class="hlt">electrons</span> is caused by chorus that can cause relativistic <span class="hlt">electron</span> microbursts.« less</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li class="active"><span>8</span></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_8 --> <div id="page_9" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li class="active"><span>9</span></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="161"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016JGRA..121.4835H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016JGRA..121.4835H"><span>A survey of superthermal <span class="hlt">electron</span> <span class="hlt">flux</span> depressions, or "<span class="hlt">electron</span> holes," within the illuminated Martian induced magnetosphere</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Hall, B. E. S.; Lester, M.; Nichols, J. D.; Sánchez-Cano, B.; Andrews, D. J.; Opgenoorth, H. J.; Fränz, M.</p> <p>2016-05-01</p> <p>Since Mars lacks a global intrinsic magnetic field, the solar wind interacts directly with the Martian upper atmosphere and ionosphere. The presence of localized intense remnant crustal magnetic fields adds to this interaction, making the Martian plasma system a unique environment within the solar system. Rapid reductions in the <span class="hlt">electron</span> <span class="hlt">flux</span>, referred to as "<span class="hlt">electron</span> holes," occur within the Martian induced magnetosphere (IM). We present a statistical analysis of this phenomenon identified from proxy measurements of the <span class="hlt">electron</span> <span class="hlt">flux</span> derived from measurements by the Analyser of Space Plasmas and Energetic Neutral Atoms <span class="hlt">Electron</span> Spectrometer experiment on board the Mars Express (MEX) spacecraft. The study is completed for the period of 9 February 2004 to 9 May 2014. <span class="hlt">Electron</span> holes are observed within the IM in more than 56% of MEX orbits during this study period, occurring predominantly at altitudes less than 1300 km, with the majority in the negative X Mars-Centric Solar Orbital direction. The spatial distribution above the surface of Mars is observed to bear close resemblance to that of the crustal magnetic fields as predicted by the Cain et al. magnetic field model, suggesting that they play an important role in the formation of these phenomena.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1353474-searching-dark-matter-annihilation-recently-discovered-milky-way-satellites-fermi-lat','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1353474-searching-dark-matter-annihilation-recently-discovered-milky-way-satellites-fermi-lat"><span>Searching for Dark Matter annihilation in recently discovered Milky Way satellites with FERMI-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Albert, A.; Anderson, B.; Bechtol, K.; ...</p> <p>2017-01-06</p> <p>Here, we search for excess γ-ray emission coincident with the positions of confirmed and candidate Milky Way satellite galaxies using six years of data from the Fermi Large Area Telescope (<span class="hlt">LAT</span>). Our sample of 45 stellar systems includes 28 kinematically confirmed dark-matter-dominated dwarf spheroidal galaxies (dSphs) and 17 recently discovered systems that have photometric characteristics consistent with the population of known dSphs. For each of these targets, the relative predicted γ-ray <span class="hlt">flux</span> due to dark matter annihilation is taken from kinematic analysis if available, and estimated from a distance-based scaling relation otherwise, assuming that the stellar systems are DM-dominated dSphs. <span class="hlt">LAT</span> data coincident with four of the newly discovered targets show a slight preference (eachmore » $$\\sim $$2σ local) for γ-ray emission in excess of the background. However, the ensemble of derived γ-ray <span class="hlt">flux</span> upper limits for individual targets is consistent with the expectation from analyzing random blank-sky regions, and a combined analysis of the population of stellar systems yields no globally significant excess (global significance $$\\lt 1\\sigma $$). Our analysis has increased sensitivity compared to the analysis of 15 confirmed dSphs by Ackermann et al. The observed constraints on the DM annihilation cross section are statistically consistent with the background expectation, improving by a factor of ~2 for large DM masses ($${m}_{\\mathrm{DM},b\\bar{b}}\\gtrsim 1\\,\\mathrm{TeV}$$ and $${m}_{\\mathrm{DM},{\\tau }^{+}{\\tau }^{-}}\\gtrsim 70\\,\\mathrm{GeV}$$) and weakening by a factor of ~1.5 at lower masses relative to previously observed limits.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1353474','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1353474"><span>Searching for Dark Matter annihilation in recently discovered Milky Way satellites with FERMI-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Albert, A.; Anderson, B.; Bechtol, K.</p> <p></p> <p>Here, we search for excess γ-ray emission coincident with the positions of confirmed and candidate Milky Way satellite galaxies using six years of data from the Fermi Large Area Telescope (<span class="hlt">LAT</span>). Our sample of 45 stellar systems includes 28 kinematically confirmed dark-matter-dominated dwarf spheroidal galaxies (dSphs) and 17 recently discovered systems that have photometric characteristics consistent with the population of known dSphs. For each of these targets, the relative predicted γ-ray <span class="hlt">flux</span> due to dark matter annihilation is taken from kinematic analysis if available, and estimated from a distance-based scaling relation otherwise, assuming that the stellar systems are DM-dominated dSphs. <span class="hlt">LAT</span> data coincident with four of the newly discovered targets show a slight preference (eachmore » $$\\sim $$2σ local) for γ-ray emission in excess of the background. However, the ensemble of derived γ-ray <span class="hlt">flux</span> upper limits for individual targets is consistent with the expectation from analyzing random blank-sky regions, and a combined analysis of the population of stellar systems yields no globally significant excess (global significance $$\\lt 1\\sigma $$). Our analysis has increased sensitivity compared to the analysis of 15 confirmed dSphs by Ackermann et al. The observed constraints on the DM annihilation cross section are statistically consistent with the background expectation, improving by a factor of ~2 for large DM masses ($${m}_{\\mathrm{DM},b\\bar{b}}\\gtrsim 1\\,\\mathrm{TeV}$$ and $${m}_{\\mathrm{DM},{\\tau }^{+}{\\tau }^{-}}\\gtrsim 70\\,\\mathrm{GeV}$$) and weakening by a factor of ~1.5 at lower masses relative to previously observed limits.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/20658304','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/20658304"><span>Study of ring influence and <span class="hlt">electronic</span> response to proton transfer reactions. Reaction <span class="hlt">electronic</span> <span class="hlt">flux</span> analysis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Herrera, Barbara</p> <p>2011-05-01</p> <p>In this article, a theoretical study of 1-5 proton transfers is presented. Two model systems which represent 1-5 proton transfer, 3-hidroxy-2-propenimine and salicyldenaniline have been studied as shown in Fig. 1. For this purpose, a DFT/B3LYP/6-311+G**, reaction force and reaction <span class="hlt">electronic</span> <span class="hlt">flux</span> analysis is made. The obtained results indicate that both proton transfers exhibit energetic and <span class="hlt">electronic</span> differences emphasizing the role of the neighbor ring and the impact of conjugation on <span class="hlt">electronic</span> properties.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2007AIPC..963..345F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2007AIPC..963..345F"><span>The <span class="hlt">Electronic</span> <span class="hlt">Flux</span> in Chemical Reactions. Insights on the Mechanism of the Maillard Reaction</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Flores, Patricio; Gutiérrez-Oliva, Soledad; Herrera, Bárbara; Silva, Eduardo; Toro-Labbé, Alejandro</p> <p>2007-11-01</p> <p>The <span class="hlt">electronic</span> transfer that occurs during a chemical process is analysed in term of a new concept, the <span class="hlt">electronic</span> <span class="hlt">flux</span>, that allows characterizing the regions along the reaction coordinate where <span class="hlt">electron</span> transfer is actually taking place. The <span class="hlt">electron</span> <span class="hlt">flux</span> is quantified through the variation of the <span class="hlt">electronic</span> chemical potential with respect to the reaction coordinate and is used, together with the reaction force, to shed light on reaction mechanism of the Schiff base formation in the Maillard reaction. By partitioning the reaction coordinate in regions in which different process might be taking place, <span class="hlt">electronic</span> reordering associated to polarization and transfer has been identified and found to be localized at specific transition state regions where most bond forming and breaking occur.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20110023417','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20110023417"><span>On the Relationship Between High Speed Solar Wind Streams and Radiation Belt <span class="hlt">Electron</span> <span class="hlt">Fluxes</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Zheng, Yihua</p> <p>2011-01-01</p> <p>Both past and recent research results indicate that solar wind speed has a close connection to radiation belt <span class="hlt">electron</span> <span class="hlt">fluxes</span> [e.g., Paulikas and Blake, 1979; Reeves et aI., 2011]: a higher solar wind speed is often associated with a higher level of radiation <span class="hlt">electron</span> <span class="hlt">fluxes</span>. But the relationship can be very complex [Reeves et aI., 2011]. The study presented here provides further corroboration of this viewpoint by emphasizing the importance of a global perspective and time history. We find that all the events during years 2010 and 2011 where the >0.8 MeV integral <span class="hlt">electron</span> <span class="hlt">flux</span> exceeds 10(exp 5) particles/sq cm/sr/s (pfu) at GEO orbit are associated with the high speed streams (HSS) following the onset of the Stream Interaction Region (SIR), with most of them belonging to the long-lasting Corotating Interaction Region (CIR). Our preliminary results indicate that during HSS events, a maximum speed of 700 km/s and above is a sufficient but not necessary condition for the > 0.8 MeV <span class="hlt">electron</span> <span class="hlt">flux</span> to reach 10(exp 5) pfu. But in the exception cases of HSS events where the <span class="hlt">electron</span> <span class="hlt">flux</span> level exceeds the 10(exp 5) pfu value but the maximum solar wind speed is less than 700 km/s, a prior impact can be noted either from a CME or a transient SIR within 3-4 days before the arrival of the HSS - stressing the importance of time history. Through superposed epoch analysis and studies providing comparisons with the CME events and the HSS events where the <span class="hlt">flux</span> level fails to reach the 10(exp 5) pfu, we will present the quantitative assessment of behaviors and relationships of various quantities, such as the time it takes to reach the <span class="hlt">flux</span> threshold value from the stream interface and its dependence on different physical parameters (e.g., duration of the HSS event, its maximum or average of the solar wind speed, IMF Bz, Kp). The ultimate goal is to apply what is derived to space weather forecasting.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013ATel.4694....1D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013ATel.4694....1D"><span>Fermi-<span class="hlt">LAT</span> detection of a new gamma-ray flare from the NLSy1 PMN J0948+0022</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>D'Ammando, F.; Orienti, M.</p> <p>2013-01-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed an increasing gamma-ray <span class="hlt">flux</span> from a source positionally consistent with PMN J0948+0022 (also known as 2FGL J0948.8+0020, Nolan et al. 2012, ApJS, 199, 31; R.A.= 09h48m57.3201s, Dec.= +00d22'25.558", J2000, Beasley et al. 2002, ApJS, 141, 13), a radio-loud narrow-line Seyfert 1 at z=0.5846 (Sloan Digital Sky Survey, 2004, SDSS2.C).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19950057072&hterms=coverage&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D80%26Ntt%3Dcoverage','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19950057072&hterms=coverage&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D80%26Ntt%3Dcoverage"><span>Relativistic <span class="hlt">electron</span> <span class="hlt">flux</span> comparisons at low and high altitudes with fast time resolution and broad spatial coverage</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Imhof, W. L.; Gaines, E. E.; Mcglennon, J. P.; Baker, D. N.; Reeves, G. D.; Belian, R. D.</p> <p>1994-01-01</p> <p>Analyses are presented for the first high-time resolution multisatellite study of the spatial and temporal characteristics of a relativistic <span class="hlt">electron</span> enhancement event with a rapid onset. Measurements of MeV <span class="hlt">electrons</span> were made from two low-altitude polar orbiting satellites and three spacecraft at synchronous altitude. The <span class="hlt">electron</span> <span class="hlt">fluxes</span> observed by the low-altitude satellites include precipitating <span class="hlt">electrons</span> in both the bounce and drift loss cones as well as <span class="hlt">electrons</span> that are stably trapped, whereas the observations at geosynchronous altitude are dominated by the trapped population. The <span class="hlt">fluxes</span> of greater than 1 MeV <span class="hlt">electrons</span> at low-satellite altitude over a wide range of L shells tracked very well the <span class="hlt">fluxes</span> greater than 0.93 MeV at synchronous altitude.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011APS..DPPYI3003M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011APS..DPPYI3003M"><span>Nonlocal <span class="hlt">electron</span> energy transport and <span class="hlt">flux</span> inhibition in laser produced plasmas in one and two dimensions</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Manheimer, Wallace</p> <p>2011-10-01</p> <p>As the mean free path of the heat conducting <span class="hlt">electrons</span> in laser produced plasmas can, at certain points, be greater than the temperature gradient scale length, the classical, local model can be invalid. More energetic <span class="hlt">electrons</span> can advance ahead of the main heat front and preheat the fusion target. Also, experiments show that the main heat front does not propagate as rapidly as classical theory would predict, so there is heat <span class="hlt">flux</span> inhibition. This latter effect is usually treated by limiting the <span class="hlt">flux</span> to some arbitrary fraction f of the free streaming <span class="hlt">flux</span>; f's have ranged from 0.03 to 0.3. However the choice of <span class="hlt">flux</span> limit is arbitrary and the choice affects plasma temperature, which in turn affects thresholds for laser plasma instabilities; too low a limit has given too high a temperature and false optimism regarding instability threshold. We have developed a velocity dependent Krook model for nonlocal <span class="hlt">electron</span> energy transport. It shows preheat and <span class="hlt">flux</span> limitation are not separate effects, but are two sides of the same coin. The model gives an analytic solution for the nonlocal <span class="hlt">electron</span> energy <span class="hlt">flux</span>, and it is relatively simple and inexpensive to incorporate in a fluid simulation run at the ion time scale. It shows that in some sense, preheat is subtracted from the main <span class="hlt">electron</span> energy <span class="hlt">flux</span>, thereby giving rise to <span class="hlt">flux</span> limitation. We have developed the theory and compared it with Fokker Planck simulations of simple configurations. We have incorporated the model into our code FAST2D and used it to model foil acceleration and evaluate and compare a number of competing physical effects in one and two dimensions, and compared with experiments. We have investigated the effect on spherical implosions, especially the effect on corona temperature, pressure, fuel adiabat and preheat, and ultimately gain. Supported by ONR and NNSA/DoE.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018AAS...23125020T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018AAS...23125020T"><span>The Fermi <span class="hlt">LAT</span> Very Important Project (VIP) List of Active Galactic Nuclei</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Thompson, David J.; Fermi Large Area Telescope Collaboration</p> <p>2018-01-01</p> <p>Using nine years of Fermi Gamma-ray Space Telescope Large Area Telescope (<span class="hlt">LAT</span>) observations, we have identified 30 projects for Active Galactic Nuclei (AGN) that appear to provide strong prospects for significant scientific advances. This Very Important Project (VIP) AGN list includes AGNs that have good multiwavelength coverage, are regularly detected by the Fermi <span class="hlt">LAT</span>, and offer scientifically interesting timing or spectral properties. Each project has one or more <span class="hlt">LAT</span> scientists identified who are actively monitoring the source. They will be regularly updating the <span class="hlt">LAT</span> results for these VIP AGNs, working together with multiwavelength observers and theorists to maximize the scientific return during the coming years of the Fermi mission. See https://confluence.slac.stanford.edu/display/GLAMCOG/VIP+List+of+AGNs+for+Continued+Study</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016JGRA..121.6400S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016JGRA..121.6400S"><span>Nonstorm time dropout of radiation belt <span class="hlt">electron</span> <span class="hlt">fluxes</span> on 24 September 2013</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Su, Zhenpeng; Gao, Zhonglei; Zhu, Hui; Li, Wen; Zheng, Huinan; Wang, Yuming; Wang, Shui; Spence, H. E.; Reeves, G. D.; Baker, D. N.; Blake, J. B.; Funsten, H. O.; Wygant, J. R.</p> <p>2016-07-01</p> <p>Radiation belt <span class="hlt">electron</span> <span class="hlt">flux</span> dropouts during the main phase of geomagnetic storms have received increasing attention in recent years. Here we focus on a rarely reported nonstorm time dropout event observed by Van Allen Probes on 24 September 2013. Within several hours, the radiation belt <span class="hlt">electron</span> <span class="hlt">fluxes</span> exhibited a significant (up to 2 orders of magnitude) depletion over a wide range of radial distances (L > 4.5), energies (˜500 keV to several MeV) and equatorial pitch angles (0°≤αe≤180°). STEERB simulations show that the relativistic <span class="hlt">electron</span> loss in the region L = 4.5-6.0 was primarily caused by the pitch angle scattering of observed plasmaspheric hiss and electromagnetic ion cyclotron waves. Our results emphasize the complexity of radiation belt dynamics and the importance of wave-driven precipitation loss even during nonstorm times.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUFMSM41B2433G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUFMSM41B2433G"><span><span class="hlt">Electron</span> Injections: A Study of <span class="hlt">Electron</span> Acceleration by Multiple Dipolarizing <span class="hlt">Flux</span> Bundles Using an Analytical Model</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gabrielse, C.; Angelopoulos, V.; Artemyev, A.; Runov, A.; Harris, C.</p> <p>2016-12-01</p> <p>We study energetic <span class="hlt">electron</span> injections using an analytical model that self-consistently describes electric and magnetic field perturbations of transient, localized dipolarizing <span class="hlt">flux</span> bundles (DFBs). Previous studies using THEMIS, Van Allen Probes, and the Magnetospheric Multiscale Mission have shown that injections can occur on short (minutes) or long (10s of minutes) timescales. These studies suggest that the short timescale injections correspond to a single DFB, whereas long timescale injections are likely caused by an aggregate of multiple DFBs, each incrementally heating the particle population. We therefore model the effects of multiple DFBs on the <span class="hlt">electron</span> population using multi-spacecraft observations of the fields and particle <span class="hlt">fluxes</span> to constrain the model parameters. The analytical model is the first of its kind to model multiple dipolarization fronts in order to better understand the transport and acceleration process throughout the plasma sheet. It can reproduce most injection signatures at multiple locations simultaneously, reaffirming earlier findings that multiple earthward-traveling DFBs can both transport and accelerate <span class="hlt">electrons</span> to suprathermal energies, and can thus be considered the injections' primary driver.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5013661','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5013661"><span><span class="hlt">Electron-flux</span> infrared response to varying π-bond topology in charged aromatic monomers</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Álvaro Galué, Héctor; Oomens, Jos; Buma, Wybren Jan; Redlich, Britta</p> <p>2016-01-01</p> <p>The interaction of delocalized π-<span class="hlt">electrons</span> with molecular vibrations is key to charge transport processes in π-conjugated organic materials based on aromatic monomers. Yet the role that specific aromatic motifs play on charge transfer is poorly understood. Here we show that the molecular edge topology in charged catacondensed aromatic hydrocarbons influences the Herzberg-Teller coupling of π-<span class="hlt">electrons</span> with molecular vibrations. To this end, we probe the radical cations of picene and pentacene with benchmark armchair- and zigzag-edges using infrared multiple-photon dissociation action spectroscopy and interpret the recorded spectra via quantum-chemical calculations. We demonstrate that infrared bands preserve information on the dipolar π-<span class="hlt">electron-flux</span> mode enhancement, which is governed by the dynamical evolution of vibronically mixed and correlated one-<span class="hlt">electron</span> configuration states. Our results reveal that in picene a stronger charge π-<span class="hlt">flux</span> is generated than in pentacene, which could justify the differences of <span class="hlt">electronic</span> properties of armchair- versus zigzag-type families of technologically relevant organic molecules. PMID:27577323</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24762008','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24762008"><span>Monoterpene glycoside ESK246 from Pittosporum targets <span class="hlt">LAT</span>3 amino acid transport and prostate cancer cell growth.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wang, Qian; Grkovic, Tanja; Font, Josep; Bonham, Sarah; Pouwer, Rebecca H; Bailey, Charles G; Moran, Anne M; Ryan, Renae M; Rasko, John E J; Jormakka, Mika; Quinn, Ronald J; Holst, Jeff</p> <p>2014-06-20</p> <p>The L-type amino acid transporter (<span class="hlt">LAT</span>) family consists of four members (<span class="hlt">LAT</span>1-4) that mediate uptake of neutral amino acids including leucine. Leucine is not only important as a building block for proteins, but plays a critical role in mTORC1 signaling leading to protein translation. As such, <span class="hlt">LAT</span> family members are commonly upregulated in cancer in order to fuel increased protein translation and cell growth. To identify potential <span class="hlt">LAT</span>-specific inhibitors, we established a function-based high-throughput screen using a prefractionated natural product library. We identified and purified two novel monoterpene glycosides, ESK242 and ESK246, sourced from a Queensland collection of the plant Pittosporum venulosum. Using Xenopus laevis oocytes expressing individual <span class="hlt">LAT</span> family members, we demonstrated that ESK246 preferentially inhibits leucine transport via <span class="hlt">LAT</span>3, while ESK242 inhibits both <span class="hlt">LAT</span>1 and <span class="hlt">LAT</span>3. We further show in LNCaP prostate cancer cells that ESK246 is a potent (IC50 = 8.12 μM) inhibitor of leucine uptake, leading to reduced mTORC1 signaling, cell cycle protein expression and cell proliferation. Our study suggests that ESK246 is a <span class="hlt">LAT</span>3 inhibitor that can be used to study <span class="hlt">LAT</span>3 function and upon which new antiprostate cancer therapies may be based.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4068216','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4068216"><span>Monoterpene Glycoside ESK246 from Pittosporum Targets <span class="hlt">LAT</span>3 Amino Acid Transport and Prostate Cancer Cell Growth</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2014-01-01</p> <p>The l-type amino acid transporter (<span class="hlt">LAT</span>) family consists of four members (<span class="hlt">LAT</span>1–4) that mediate uptake of neutral amino acids including leucine. Leucine is not only important as a building block for proteins, but plays a critical role in mTORC1 signaling leading to protein translation. As such, <span class="hlt">LAT</span> family members are commonly upregulated in cancer in order to fuel increased protein translation and cell growth. To identify potential <span class="hlt">LAT</span>-specific inhibitors, we established a function-based high-throughput screen using a prefractionated natural product library. We identified and purified two novel monoterpene glycosides, ESK242 and ESK246, sourced from a Queensland collection of the plant Pittosporum venulosum. Using Xenopus laevis oocytes expressing individual <span class="hlt">LAT</span> family members, we demonstrated that ESK246 preferentially inhibits leucine transport via <span class="hlt">LAT</span>3, while ESK242 inhibits both <span class="hlt">LAT</span>1 and <span class="hlt">LAT</span>3. We further show in LNCaP prostate cancer cells that ESK246 is a potent (IC50 = 8.12 μM) inhibitor of leucine uptake, leading to reduced mTORC1 signaling, cell cycle protein expression and cell proliferation. Our study suggests that ESK246 is a <span class="hlt">LAT</span>3 inhibitor that can be used to study <span class="hlt">LAT</span>3 function and upon which new antiprostate cancer therapies may be based. PMID:24762008</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1355671-second-catalog-hard-fermi-lat-sources','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1355671-second-catalog-hard-fermi-lat-sources"><span>2FHL: The Second Catalog of Hard Fermi-<span class="hlt">LAT</span> Sources</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Ackermann, M.; Ajello, M.; Atwood, W. B.; ...</p> <p>2016-01-14</p> <p>We present a catalog of sources detected above 50 GeV by the Fermi-Large Area Telescope (<span class="hlt">LAT</span>) in 80 months of data. The newly delivered Pass 8 event-level analysis allows the detection and characterization of sources in the 50 GeV–2TeV energy range. In this energy band, Fermi - <span class="hlt">LAT</span> has detected 360 sources, which constitute the second catalog of hard Fermi -<span class="hlt">LAT</span> sources (2FHL). The improved angular resolution enables the precise localization of point sources (~1.'7 radius at 68 % C. L.) and the detection and characterization of spatially extended sources. We find that 86% of the sources can be associatedmore » with counterparts at other wavelengths, of which the majority (75%) are active galactic nuclei and the rest (11%) are Galactic sources. Only 25% of the 2FHL sources have been previously detected by Cherenkov telescopes, implying that the 2FHL provides a reservoir of candidates to be followed up at very high energies. This work closes the energy gap between the observations performed at GeV energies by Fermi -<span class="hlt">LAT</span> on orbit and the observations performed at higher energies by Cherenkov telescopes from the ground.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20170003190&hterms=hard&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3Dhard','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20170003190&hterms=hard&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3Dhard"><span>2FHL- The Second Catalog of Hard Fermi-<span class="hlt">LAT</span> Sources</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ackermann, M.; Ajello, M.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Gonzalez, J. Becerra; Bellazzini, R.; Bissaldi, E.; <a style="text-decoration: none; " href="javascript:void(0); " onClick="displayelement('author_20170003190'); toggleEditAbsImage('author_20170003190_show'); toggleEditAbsImage('author_20170003190_hide'); "> <img style="display:inline; width:12px; height:12px; " src="images/arrow-up.gif" width="12" height="12" border="0" alt="hide" id="author_20170003190_show"> <img style="width:12px; height:12px; display:none; " src="images/arrow-down.gif" width="12" height="12" border="0" alt="hide" id="author_20170003190_hide"></p> <p>2016-01-01</p> <p>We present a catalog of sources detected above 50 GeV by the Fermi-Large Area Telescope (<span class="hlt">LAT</span>) in 80 months of data. The newly delivered Pass8 event-level analysis allows the detection and characterization of sources in the 50 GeV-2 TeV energy range. In this energy band, Fermi-<span class="hlt">LAT</span> has detected 360 sources, which constitute the second catalog of hard Fermi-<span class="hlt">LAT</span> sources (2FHL). The improved angular resolution enables the precise localization of point sources (1.7 radius at 68% C.L.) and the detection and characterization of spatially extended sources. We find that 86% of the sources can be associated with counterparts at other wavelengths, of which the majority (75%) are active galactic nuclei and the rest (11%) are Galactic sources. Only 25% of the 2FHLsources have been previously detected by Cherenkov telescopes, implying that the 2FHL provides a reservoir of candidates to be followed up at very high energies. This work closes the energy gap between the observations performed at GeV energies by Fermi-<span class="hlt">LAT</span> on orbit and the observations performed at higher energies byCherenkov telescopes from the ground.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1355671','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1355671"><span>2FHL: The Second Catalog of Hard Fermi-<span class="hlt">LAT</span> Sources</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Ackermann, M.; Ajello, M.; Atwood, W. B.</p> <p></p> <p>We present a catalog of sources detected above 50 GeV by the Fermi-Large Area Telescope (<span class="hlt">LAT</span>) in 80 months of data. The newly delivered Pass 8 event-level analysis allows the detection and characterization of sources in the 50 GeV–2TeV energy range. In this energy band, Fermi - <span class="hlt">LAT</span> has detected 360 sources, which constitute the second catalog of hard Fermi -<span class="hlt">LAT</span> sources (2FHL). The improved angular resolution enables the precise localization of point sources (~1.'7 radius at 68 % C. L.) and the detection and characterization of spatially extended sources. We find that 86% of the sources can be associatedmore » with counterparts at other wavelengths, of which the majority (75%) are active galactic nuclei and the rest (11%) are Galactic sources. Only 25% of the 2FHL sources have been previously detected by Cherenkov telescopes, implying that the 2FHL provides a reservoir of candidates to be followed up at very high energies. This work closes the energy gap between the observations performed at GeV energies by Fermi -<span class="hlt">LAT</span> on orbit and the observations performed at higher energies by Cherenkov telescopes from the ground.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014ATel.5951....1A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014ATel.5951....1A"><span>Fermi <span class="hlt">LAT</span> detection of GeV flares from blazars PKS 0458-02 and B2 1144+40</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Antolini, Elisa; Buson, Sara</p> <p>2014-03-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray <span class="hlt">flux</span> from two sources positionally consistent with the flat spectrum radio quasars PKS 0458-02 (also known as 2FGL J0501.2-0155, Nolan et al. 2012 ApJS, 199, 31) and B2 1144+40 (also known as S4 1144+40 and 2FGL J1146.9+4000). PKS 0458-02 has the radio coordinates RA=05h01m12.8098s, Dec=-1d59m14.255s (J2000, Johnston et al.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013ATel.5457....1C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013ATel.5457....1C"><span>Fermi-<span class="hlt">LAT</span> detection of a GeV flare from the BL Lac object 1ES 2322-409</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ciprini, Stefano</p> <p>2013-10-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed an increasing gamma-ray <span class="hlt">flux</span> from a source positionally consistent with the BL Lac object 1ES 2322-409 (also know as 2FGL J2324.7-4042, Nolan et al. 2012, ApJS, 199, 31, and as 1FHL J2324.6-4041, Ackermann et al., ApJS, submitted, arXiv:1306.6772), with 2MASS counterpart coordinates, (J2000.0), R.A.: 351.18612 deg, Dec: -40.68036 deg (Mao 2011, New Ast., 16, 503).</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li class="active"><span>9</span></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_9 --> <div id="page_10" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li class="active"><span>10</span></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="181"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1291235-nonstorm-time-dropout-radiation-belt-electron-fluxes-september','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1291235-nonstorm-time-dropout-radiation-belt-electron-fluxes-september"><span>Nonstorm time dropout of radiation belt <span class="hlt">electron</span> <span class="hlt">fluxes</span> on 24 September 2013</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Su, Zhenpeng; Gao, Zhonglei; Reeves, Geoffrey D.; ...</p> <p>2016-07-01</p> <p>Radiation belt <span class="hlt">electron</span> <span class="hlt">flux</span> dropouts during the main phase of geomagnetic storms have received increasing attention in recent years. Here we focus on a rarely reported nonstorm time dropout event observed by Van Allen Probes on 24 September 2013. Within several hours, the radiation belt <span class="hlt">electron</span> <span class="hlt">fluxes</span> exhibited a significant (up to 2 orders of magnitude) depletion over a wide range of radial distances ( L > 4.5), energies (~500 keV to several MeV) and equatorial pitch angles (0° ≤ α e ≤ 180°). STEERB simulations show that the relativistic <span class="hlt">electron</span> loss in the region L = 4.5–6.0 was primarilymore » caused by the pitch angle scattering of observed plasmaspheric hiss and electromagnetic ion cyclotron waves. Furthermore, our results emphasize the complexity of radiation belt dynamics and the importance of wave-driven precipitation loss even during nonstorm times.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1291235','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1291235"><span>Nonstorm time dropout of radiation belt <span class="hlt">electron</span> <span class="hlt">fluxes</span> on 24 September 2013</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Su, Zhenpeng; Gao, Zhonglei; Reeves, Geoffrey D.</p> <p></p> <p>Radiation belt <span class="hlt">electron</span> <span class="hlt">flux</span> dropouts during the main phase of geomagnetic storms have received increasing attention in recent years. Here we focus on a rarely reported nonstorm time dropout event observed by Van Allen Probes on 24 September 2013. Within several hours, the radiation belt <span class="hlt">electron</span> <span class="hlt">fluxes</span> exhibited a significant (up to 2 orders of magnitude) depletion over a wide range of radial distances ( L > 4.5), energies (~500 keV to several MeV) and equatorial pitch angles (0° ≤ α e ≤ 180°). STEERB simulations show that the relativistic <span class="hlt">electron</span> loss in the region L = 4.5–6.0 was primarilymore » caused by the pitch angle scattering of observed plasmaspheric hiss and electromagnetic ion cyclotron waves. Furthermore, our results emphasize the complexity of radiation belt dynamics and the importance of wave-driven precipitation loss even during nonstorm times.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018MNRAS.475.1238K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018MNRAS.475.1238K"><span>The Fermi-<span class="hlt">LAT</span> detection of magnetar-like pulsar PSR J1846-0258 at high-energy gamma-rays</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kuiper, L.; Hermsen, W.; Dekker, A.</p> <p>2018-03-01</p> <p>We report the detection of the pulsed signal of the radio-quiet magnetar-like pulsar PSR J1846-0258 in the high-energy γ-ray data of the Fermi Large Area Telescope (Fermi <span class="hlt">LAT</span>). We produced phase-coherent timing models exploiting RXTE PCA and Swift XRT monitoring data for the post- (magnetar-like) outburst period from 2007 August 28 to 2016 September 4, with independent verification using INTEGRAL ISGRI and Fermi GBM data. Phase-folding barycentric arrival times of selected Fermi <span class="hlt">LAT</span> events from PSR J1846-0258 resulted in a 4.2σ detection (30-100 MeV) of a broad pulse consistent in shape and aligned in phase with the profiles that we measured with Swift XRT (2.5-10 keV), INTEGRAL ISGRI (20-150 keV), and Fermi GBM (20-300 keV). The pulsed <span class="hlt">flux</span> (30-100 MeV) is (3.91 ± 0.97) × 10-9 photons cm-2 s-1 MeV-1. Declining significances of the INTEGRAL ISGRI 20-150 keV pulse profiles suggest fading of the pulsed hard X-ray emission during the post-outburst epochs. We revisited with greatly improved statistics the timing and spectral characteristics of PSR B1509-58 as measured with the Fermi <span class="hlt">LAT</span>. The broad-band pulsed emission spectra (from 2 keV up to GeV energies) of PSR J1846-0258 and PSR B1509-58 can be accurately described with similarly curved shapes, with maximum luminosities at 3.5 ± 1.1 MeV (PSR J1846-0258) and 2.23 ± 0.11 MeV (PSR B1509-58). We discuss possible explanations for observational differences between Fermi <span class="hlt">LAT</span> detected pulsars that reach maximum luminosities at GeV energies, like the second magnetar-like pulsar PSR J1119-6127, and pulsars with maximum luminosities at MeV energies, which might be due to geometric differences rather than exotic physics in high-B fields.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/6765718-time-series-analysis-energetic-electron-fluxes-mev-geosynchronous-altitude-master-thesis','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/6765718-time-series-analysis-energetic-electron-fluxes-mev-geosynchronous-altitude-master-thesis"><span>Time-series analysis of energetic <span class="hlt">electron</span> <span class="hlt">fluxes</span> (1. 2 - 16 MeV) at geosynchronous altitude. Master's thesis</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Halpin, M.P.</p> <p></p> <p>This project used a Box and Jenkins time-series analysis of energetic <span class="hlt">electron</span> <span class="hlt">fluxes</span> measured at geosynchronous orbit in an effort to derive prediction models for the <span class="hlt">flux</span> in each of five energy channels. In addition, the technique of transfer function modeling described by Box and Jenkins was used in an attempt to derive input-output relationships between the <span class="hlt">flux</span> channels (viewed as the output) and the solar-wind speed or interplanetary magnetic field (IMF) north-south component, Bz, (viewed as the input). The transfer function modeling was done in order to investigate the theoretical dynamic relationship which is believed to exist between themore » solar wind, the IMF Bz, and the energetic <span class="hlt">electron</span> <span class="hlt">flux</span> in the magnetosphere. The models derived from the transfer-function techniques employed were also intended to be used in the prediction of <span class="hlt">flux</span> values. The results from this study indicate that the energetic <span class="hlt">electron</span> <span class="hlt">flux</span> changes in the various channels are dependent on more than simply the solar-wind speed or the IMF Bz.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017IAUS..324..115Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017IAUS..324..115Z"><span>What can Fermi <span class="hlt">LAT</span> observation of the Galactic Centre tell us about its active past?</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zaharijas, Gabrijela; Petrović, Jovana; Serpico, Pasquale</p> <p></p> <p>The Fermi-<span class="hlt">LAT</span> gamma-ray data in the inner Galaxy region show several prominent features possibly related to the past activity of the Milky Way's super massive black hole. At a large, 50 deg scale, the Fermi <span class="hlt">LAT</span> revealed symmetric hour glass structures with hard energy spectra extending up to 100 GeV (and dubbed `the Fermi bubbles'). More recently and closer to the Galactic centre, at the 10 deg scale, several groups have claimed evidence for excess gamma-ray emission that appears symmetric around the Galactic center and has an energy spectrum peaking at few GeVs. We explore here the possibility that this emission originates in inverse Compton emission from high-energy <span class="hlt">electrons</span> produced in a short duration, burst-like event injecting 1052 - 1053 erg, roughly 106 yrs ago. Several lines of evidence suggest that a series of `burst like' events happened in the vicinity of our black hole in the past and gamma-ray observations may offer a new view of that scenario.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20170002394&hterms=cluster&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3Dcluster','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20170002394&hterms=cluster&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3Dcluster"><span>Van Allen Probes, THEMIS, GOES, and Cluster Observations of EMIC Waves, ULF Pulsations, and an <span class="hlt">Electron</span> <span class="hlt">Flux</span> Dropout</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Sigsbee, K.; Kletzing, C. A.; Smith, C. W.; Macdowall, R.; Spence, H.; Reeves, G.; Blake, J. B.; Baker, D. N.; Green, J. C.; Singer, H. J.; <a style="text-decoration: none; " href="javascript:void(0); " onClick="displayelement('author_20170002394'); toggleEditAbsImage('author_20170002394_show'); toggleEditAbsImage('author_20170002394_hide'); "> <img style="display:inline; width:12px; height:12px; " src="images/arrow-up.gif" width="12" height="12" border="0" alt="hide" id="author_20170002394_show"> <img style="width:12px; height:12px; display:none; " src="images/arrow-down.gif" width="12" height="12" border="0" alt="hide" id="author_20170002394_hide"></p> <p>2016-01-01</p> <p>We examined an <span class="hlt">electron</span> <span class="hlt">flux</span> dropout during the 12-14 November 2012 geomagnetic storm using observations from seven spacecraft: the two Van Allen Probes, Time History of Events and Macroscale Interactions during Substorms (THEMIS)-A (P5), Cluster 2, and Geostationary Operational Environmental Satellites (GOES) 13, 14, and 15. The <span class="hlt">electron</span> <span class="hlt">fluxes</span> for energies greater than 2.0 MeV observed by GOES 13, 14, and 15 at geosynchronous orbit and by the Van Allen Probes remained at or near instrumental background levels for more than 24 h from 12 to 14 November. For energies of 0.8 MeV, the GOES satellites observed two shorter intervals of reduced <span class="hlt">electron</span> <span class="hlt">fluxes</span>. The first interval of reduced 0.8 MeV <span class="hlt">electron</span> <span class="hlt">fluxes</span> on 12-13 November was associated with an interplanetary shock and a sudden impulse. Cluster, THEMIS, and GOES observed intense He+ electromagnetic ion cyclotron (EMIC) waves from just inside geosynchronous orbit out to the magnetopause across the dayside to the dusk flank. The second interval of reduced 0.8 MeV <span class="hlt">electron</span> <span class="hlt">fluxes</span> on 13-14 November was associated with a solar sector boundary crossing and development of a geomagnetic storm with Dst<100 nT. At the start of the recovery phase, both the 0.8 and 2.0 MeV <span class="hlt">electron</span> <span class="hlt">fluxes</span> finally returned to near prestorm values, possibly in response to strong ultralow frequency (ULF) waves observed by the Van Allen Probes near dawn. A combination of adiabatic effects, losses to the magnetopause, scattering by EMIC waves, and acceleration by ULF waves can explain the observed <span class="hlt">electron</span> behavior.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013hell.conf...16G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013hell.conf...16G"><span>Energetic <span class="hlt">electron</span> <span class="hlt">flux</span> enhancements during geospace magnetic storms associated with earthward penetration of Pc 4-5 waves?</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Georgiou, M.; Daglis, I.; Zesta, E.; Balasis, G., Tsinganos, K.</p> <p>2013-09-01</p> <p>ULF waves with frequencies of a few millihertz (mHz) have been associated with changes in the <span class="hlt">flux</span> levels among relativistic <span class="hlt">electrons</span> comprising the outer zone of the radiation belts. In particular, the <span class="hlt">fluxes</span> of <span class="hlt">electrons</span> with energies > 1 MeV in the outer radiation belt increase and decrease during geospace magnetic storms. For all storms studied by Reeves et al. [2003], only about half of them led to increased <span class="hlt">electron</span> <span class="hlt">fluxes</span>, one quarter led to decreased the <span class="hlt">fluxes</span>, and one quarter produced little or no change in the <span class="hlt">fluxes</span>. We focus on the increase of relativistic <span class="hlt">electrons</span> observed during a number of magnetic storms by GOES satellites at geosynchronous orbit. To minimise the effects caused by the Earth's magnetic field asymmetries, we apply a statistical reconstruction of the <span class="hlt">fluxes</span> to a common local time, which is chosen to be noon, a technique proposed by O’Brien et al. [2001]. Next, we look into multipoint observations from ground-based magnetometer arrays and the characteristics of Pc 4-5 waves during the different phases of the magnetic storms with particular emphasis on the distribution of Pc 4-5 wave power over the L shells that correspond to the radiation belts. With these observations as a starting point, we investigate whether Pc 4-5 wave power penetrates to lower L shells during periods of enhanced relativistic <span class="hlt">electron</span> <span class="hlt">fluxes</span>. We discuss, lastly, the implications to wave-particle interaction. The research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7-SPACE-2011-1) under grant agreement n. 284520 for the MAARBLE (Monitoring, Analyzing and Assessing Radiation Belt Energization and Loss) collaborative research project.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013AGUFMSM33A2171P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013AGUFMSM33A2171P"><span>Prediction of high-energy radiation belt <span class="hlt">electron</span> <span class="hlt">fluxes</span> using a combined VERB-NARMAX model</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Pakhotin, I. P.; Balikhin, M. A.; Shprits, Y.; Subbotin, D.; Boynton, R.</p> <p>2013-12-01</p> <p>This study is concerned with the modelling and forecasting of energetic <span class="hlt">electron</span> <span class="hlt">fluxes</span> that endanger satellites in space. By combining data-driven predictions from the NARMAX methodology with the physics-based VERB code, it becomes possible to predict <span class="hlt">electron</span> <span class="hlt">fluxes</span> with a high level of accuracy and across a radial distance from inside the local acceleration region to out beyond geosynchronous orbit. The model coupling also makes is possible to avoid accounting for seed <span class="hlt">electron</span> variations at the outer boundary. Conversely, combining a convection code with the VERB and NARMAX models has the potential to provide even greater accuracy in forecasting that is not limited to geostationary orbit but makes predictions across the entire outer radiation belt region.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1258442-van-allen-probes-themis-goes-cluster-observations-emic-waves-ulf-pulsations-electron-flux-dropout','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1258442-van-allen-probes-themis-goes-cluster-observations-emic-waves-ulf-pulsations-electron-flux-dropout"><span>Van Allen Probes, THEMIS, GOES, and cluster observations of EMIC waves, ULF pulsations, and an <span class="hlt">electron</span> <span class="hlt">flux</span> dropout</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Sigsbee, K.; Kletzing, C. A.; Smith, C. W.; ...</p> <p>2016-03-04</p> <p>We examined an <span class="hlt">electron</span> <span class="hlt">flux</span> dropout during the 12–14 November 2012 geomagnetic storm using observations from seven spacecraft: the two Van Allen Probes, Time History of Events and Macroscale Interactions during Substorms (THEMIS)-A (P5), Cluster 2, and Geostationary Operational Environmental Satellites (GOES) 13, 14, and 15. The <span class="hlt">electron</span> <span class="hlt">fluxes</span> for energies greater than 2.0 MeV observed by GOES 13, 14, and 15 at geosynchronous orbit and by the Van Allen Probes remained at or near instrumental background levels for more than 24 h from 12 to 14 November. For energies of 0.8 MeV, the GOES satellites observed two shorter intervalsmore » of reduced <span class="hlt">electron</span> <span class="hlt">fluxes</span>. The first interval of reduced 0.8 MeV <span class="hlt">electron</span> <span class="hlt">fluxes</span> on 12–13 November was associated with an interplanetary shock and a sudden impulse. Cluster, THEMIS, and GOES observed intense He + electromagnetic ion cyclotron (EMIC) waves from just inside geosynchronous orbit out to the magnetopause across the dayside to the dusk flank. The second interval of reduced 0.8 MeV <span class="hlt">electron</span> <span class="hlt">fluxes</span> on 13–14 November was associated with a solar sector boundary crossing and development of a geomagnetic storm with Dst <–100 nT. At the start of the recovery phase, both the 0.8 and 2.0 MeV <span class="hlt">electron</span> <span class="hlt">fluxes</span> finally returned to near prestorm values, possibly in response to strong ultralow frequency (ULF) waves observed by the Van Allen Probes near dawn. A combination of adiabatic effects, losses to the magnetopause, scattering by EMIC waves, and acceleration by ULF waves can explain the observed <span class="hlt">electron</span> behavior.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1258442','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1258442"><span>Van Allen Probes, THEMIS, GOES, and cluster observations of EMIC waves, ULF pulsations, and an <span class="hlt">electron</span> <span class="hlt">flux</span> dropout</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Sigsbee, K.; Kletzing, C. A.; Smith, C. W.</p> <p></p> <p>We examined an <span class="hlt">electron</span> <span class="hlt">flux</span> dropout during the 12–14 November 2012 geomagnetic storm using observations from seven spacecraft: the two Van Allen Probes, Time History of Events and Macroscale Interactions during Substorms (THEMIS)-A (P5), Cluster 2, and Geostationary Operational Environmental Satellites (GOES) 13, 14, and 15. The <span class="hlt">electron</span> <span class="hlt">fluxes</span> for energies greater than 2.0 MeV observed by GOES 13, 14, and 15 at geosynchronous orbit and by the Van Allen Probes remained at or near instrumental background levels for more than 24 h from 12 to 14 November. For energies of 0.8 MeV, the GOES satellites observed two shorter intervalsmore » of reduced <span class="hlt">electron</span> <span class="hlt">fluxes</span>. The first interval of reduced 0.8 MeV <span class="hlt">electron</span> <span class="hlt">fluxes</span> on 12–13 November was associated with an interplanetary shock and a sudden impulse. Cluster, THEMIS, and GOES observed intense He + electromagnetic ion cyclotron (EMIC) waves from just inside geosynchronous orbit out to the magnetopause across the dayside to the dusk flank. The second interval of reduced 0.8 MeV <span class="hlt">electron</span> <span class="hlt">fluxes</span> on 13–14 November was associated with a solar sector boundary crossing and development of a geomagnetic storm with Dst <–100 nT. At the start of the recovery phase, both the 0.8 and 2.0 MeV <span class="hlt">electron</span> <span class="hlt">fluxes</span> finally returned to near prestorm values, possibly in response to strong ultralow frequency (ULF) waves observed by the Van Allen Probes near dawn. A combination of adiabatic effects, losses to the magnetopause, scattering by EMIC waves, and acceleration by ULF waves can explain the observed <span class="hlt">electron</span> behavior.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20170003550&hterms=energy&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D80%26Ntt%3Denergy','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20170003550&hterms=energy&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D80%26Ntt%3Denergy"><span>Fermi-<span class="hlt">Lat</span> Observations of High-Energy Gamma-Ray Emission Toward the Galactic Center</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ajello, M.; Albert, A.; Atwood, W.B.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Bissaldi, E.; Blandford, R. D.; Brandt, T. J.; <a style="text-decoration: none; " href="javascript:void(0); " onClick="displayelement('author_20170003550'); toggleEditAbsImage('author_20170003550_show'); toggleEditAbsImage('author_20170003550_hide'); "> <img style="display:inline; width:12px; height:12px; " src="images/arrow-up.gif" width="12" height="12" border="0" alt="hide" id="author_20170003550_show"> <img style="width:12px; height:12px; display:none; " src="images/arrow-down.gif" width="12" height="12" border="0" alt="hide" id="author_20170003550_hide"></p> <p>2016-01-01</p> <p>The Fermi Large Area Telescope (<span class="hlt">LAT</span>) has provided the most detailed view to date of the emission toward the Galactic center (GC) in high-energy gamma-rays. This paper describes the analysis of data taken during the first 62 months of the mission in the energy range 1-100 GeV from a 15 degrees x 15 degrees region about the direction of the GC. Specialized interstellar emission models (IEMs) are constructed to enable the separation of the gamma-ray emissions produced by cosmic ray particles interacting with the interstellar gas and radiation fields in the Milky Way into that from the inner 1 kpc surrounding the GC, and that from the rest of the Galaxy. A catalog of point sources for the 15 degrees x 15 degrees region is self-consistently constructed using these IEMs: the First Fermi-<span class="hlt">LAT</span> Inner Galaxy Point SourceCatalog (1FIG). The spatial locations, <span class="hlt">fluxes</span>, and spectral properties of the 1FIG sources are presented, and compared with gamma-ray point sources over the same region taken from existing catalogs. After subtracting the interstellar emission and point-source contributions a residual is found. If templates that peak toward the GC areused to model the positive residual the agreement with the data improves, but none of the additional templates tried account for all of its spatial structure. The spectrum of the positive residual modeled with these templates has a strong dependence on the choice of IEM.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018PPCF...60f5002K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018PPCF...60f5002K"><span>Intermittent <span class="hlt">electron</span> density and temperature fluctuations and associated <span class="hlt">fluxes</span> in the Alcator C-Mod scrape-off layer</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kube, R.; Garcia, O. E.; Theodorsen, A.; Brunner, D.; Kuang, A. Q.; LaBombard, B.; Terry, J. L.</p> <p>2018-06-01</p> <p>The Alcator C-Mod mirror Langmuir probe system has been used to sample data time series of fluctuating plasma parameters in the outboard mid-plane far scrape-off layer. We present a statistical analysis of one second long time series of <span class="hlt">electron</span> density, temperature, radial electric drift velocity and the corresponding particle and <span class="hlt">electron</span> heat <span class="hlt">fluxes</span>. These are sampled during stationary plasma conditions in an ohmically heated, lower single null diverted discharge. The <span class="hlt">electron</span> density and temperature are strongly correlated and feature fluctuation statistics similar to the ion saturation current. Both <span class="hlt">electron</span> density and temperature time series are dominated by intermittent, large-amplitude burst with an exponential distribution of both burst amplitudes and waiting times between them. The characteristic time scale of the large-amplitude bursts is approximately 15 μ {{s}}. Large-amplitude velocity fluctuations feature a slightly faster characteristic time scale and appear at a faster rate than <span class="hlt">electron</span> density and temperature fluctuations. Describing these time series as a superposition of uncorrelated exponential pulses, we find that probability distribution functions, power spectral densities as well as auto-correlation functions of the data time series agree well with predictions from the stochastic model. The <span class="hlt">electron</span> particle and heat <span class="hlt">fluxes</span> present large-amplitude fluctuations. For this low-density plasma, the radial <span class="hlt">electron</span> heat <span class="hlt">flux</span> is dominated by convection, that is, correlations of fluctuations in the <span class="hlt">electron</span> density and radial velocity. Hot and dense blobs contribute only a minute fraction of the total fluctuation driven heat <span class="hlt">flux</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFMSM51C..07K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFMSM51C..07K"><span>Relativistic <span class="hlt">electron</span> <span class="hlt">flux</span> dropout due to field line curvature during the storm on 1 June 2013</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kang, S. B.; Fok, M. C. H.; Engebretson, M. J.; Li, W.; Glocer, A.</p> <p>2017-12-01</p> <p>Significant <span class="hlt">electron</span> <span class="hlt">flux</span> depletion over a wide range of L-shell and energy, referred as a dropout, was observed by Van Allen Probes during the storm main phase on June 1, 2013. During the same period, MeV <span class="hlt">electron</span> precipitation with isotropic pitch-angle distribution was also observed in the evening sector from POES but no EMIC waves were detected from either space- or ground-based magnetometers. Based on Tsyganenko empirical magnetic field model, magnetic field lines are highly non-dipolar and stretched at the night side in the inner magnetosphere. This condition can break the first adiabatic invariant (conservation of magnetic moment) and generate pitch-angle scattering of relativistic <span class="hlt">electron</span> to the loss cone. To understand the relative roles of different physical mechanisms on this dropout event, we simulate <span class="hlt">flux</span> and phase space density of relativistic <span class="hlt">electrons</span> with event specific plasma wave intensities using the Comprehensive Inner Magnetosphere and Ionosphere (CIMI) model, as a global 4-D inner magnetosphere model. We also employ pitch-angle scattering due to field line curvature in the CIMI model. We re-configure magnetic field every minute and update electric field every 20 seconds to capture radial transport. CIMI-simulation with pitch-angle scattering due to field line curvature shows more depletion of relativistic <span class="hlt">electron</span> <span class="hlt">fluxes</span> and better agreement to observation than CIMI-simulation with radial transport only. We conclude that pitch-angle scattering due to field line curvature is one of the dominant processes for the relativistic <span class="hlt">electron</span> <span class="hlt">flux</span> dropout.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19840004988','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19840004988"><span>The Mimas ghost revisited: An analysis of the <span class="hlt">electron</span> <span class="hlt">flux</span> and <span class="hlt">electron</span> microsignatures observed in the vicinity of Mimas at Saturn</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Chenette, D. L.; Stone, E. C.</p> <p>1983-01-01</p> <p>An analysis of the <span class="hlt">electron</span> absorption signature observed by the Cosmic Ray System (CRS) on Voyage 2 near the orbit of Mimas is presented. We find that these observations cannot be explained as the absorption signature of Mimas. Combing Pioneer 11 and Voyager 2 measurements of the <span class="hlt">electron</span> <span class="hlt">flux</span> at Mimas's orbit (L=3.1), we find an <span class="hlt">electron</span> spectrum where most of the <span class="hlt">flux</span> above approx 100 keV is concentrated near 1 to 3 MeV. The expected Mimas absorption signature is calculated from this spectrum neglecting radial diffusion. A lower limit on the diffusion coefficient for MeV <span class="hlt">electrons</span> is obtained. With a diffusion coefficient this large, both the Voyager 2 and the Pioneer 11 small-scale <span class="hlt">electron</span> absorption signature observations in Mimas's orbit are enigmatic. Thus we refer to the mechanism for producing these signatures as the Mimas ghost. A cloud of material in orbit with Mimas may account for the observed <span class="hlt">electron</span> signature if the cloud is at least 1% opaque to <span class="hlt">electrons</span> across a region extending over a few hundred kilometers.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013ATel.5344....1C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013ATel.5344....1C"><span>Fermi <span class="hlt">LAT</span> Detection of a GeV Flare from the Radio-Loud Narrow-Line Sy1 1H 0323+342</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Carpenter, Bryce; Ojha, Roopesh</p> <p>2013-08-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray <span class="hlt">flux</span> from a source positionally consistent with 1H 0323+342 (RA=03h24m41.1613s, Dec=+34d10m45.856s, J2000; Beasley et al. 2002, ApJS, 141, 13) at z= 0.061 (Marcha et al. 1996, MNRAS, 281, 425). This is the second nearest radio-loud Narrow-Line Seyfert 1 galaxy, a small and important class of gamma-ray loud AGN (Abdo et al.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017PhPl...24b2109I','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017PhPl...24b2109I"><span>Transport coefficients and heat <span class="hlt">fluxes</span> in non-equilibrium high-temperature flows with <span class="hlt">electronic</span> excitation</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Istomin, V. A.; Kustova, E. V.</p> <p>2017-02-01</p> <p>The influence of <span class="hlt">electronic</span> excitation on transport processes in non-equilibrium high-temperature ionized mixture flows is studied. Two five-component mixtures, N 2 / N2 + / N / N + / e - and O 2 / O2 + / O / O + / e - , are considered taking into account the <span class="hlt">electronic</span> degrees of freedom for atomic species as well as the rotational-vibrational-<span class="hlt">electronic</span> degrees of freedom for molecular species, both neutral and ionized. Using the modified Chapman-Enskog method, the transport coefficients (thermal conductivity, shear viscosity and bulk viscosity, diffusion and thermal diffusion) are calculated in the temperature range 500-50 000 K. Thermal conductivity and bulk viscosity coefficients are strongly affected by <span class="hlt">electronic</span> states, especially for neutral atomic species. Shear viscosity, diffusion, and thermal diffusion coefficients are not sensible to <span class="hlt">electronic</span> excitation if the size of excited states is assumed to be constant. The limits of applicability for the Stokes relation are discussed; at high temperatures, this relation is violated not only for molecular species but also for <span class="hlt">electronically</span> excited atomic gases. Two test cases of strongly non-equilibrium flows behind plane shock waves corresponding to the spacecraft re-entry (Hermes and Fire II) are simulated numerically. Fluid-dynamic variables and heat <span class="hlt">fluxes</span> are evaluated in gases with <span class="hlt">electronic</span> excitation. In inviscid flows without chemical-radiative coupling, the flow-field is weakly affected by <span class="hlt">electronic</span> states; however, in viscous flows, their influence can be more important, in particular, on the convective heat <span class="hlt">flux</span>. The contribution of different dissipative processes to the heat transfer is evaluated as well as the effect of reaction rate coefficients. The competition of diffusion and heat conduction processes reduces the overall effect of <span class="hlt">electronic</span> excitation on the convective heating, especially for the Fire II test case. It is shown that reliable models of chemical reaction rates are of great</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JGRA..12211428B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JGRA..12211428B"><span><span class="hlt">Electron</span> <span class="hlt">Flux</span> Dropouts at L ˜ 4.2 From Global Positioning System Satellites: Occurrences, Magnitudes, and Main Driving Factors</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Boynton, R. J.; Mourenas, D.; Balikhin, M. A.</p> <p>2017-11-01</p> <p>Dropouts in <span class="hlt">electron</span> <span class="hlt">fluxes</span> at L ˜ 4.2 were investigated for a broad range of energies from 120 keV to 10 MeV, using 16 years of <span class="hlt">electron</span> <span class="hlt">flux</span> data from Combined X-ray Dosimeter on board Global Positioning System (GPS) satellites. Dropouts were defined as <span class="hlt">flux</span> decreases by at least a factor 4 in 12 h, or 24 h during which a decrease by at least a factor of 1.5 must occur during each 12 h time bin. Such fast and strong dropouts were automatically identified from the GPS <span class="hlt">electron</span> <span class="hlt">flux</span> data and statistics of dropout magnitudes, and occurrences were compiled as a function of <span class="hlt">electron</span> energy. Moreover, the Error Reduction Ratio analysis was employed to search for nonlinear relationships between <span class="hlt">electron</span> <span class="hlt">flux</span> dropouts and various solar wind and geomagnetic activity indices, in order to identify potential external causes of dropouts. At L ˜ 4.2, the main driving factor for the more numerous and stronger 1-10 MeV <span class="hlt">electron</span> dropouts turns out to be the southward interplanetary magnetic field Bs, suggesting an important effect from precipitation loss due to combined electromagnetic ion cyclotron and whistler mode waves in a significant fraction of these events, supplementing magnetopause shadowing and outward radial diffusion which are also effective at lower energies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1354847-constraints-intergalactic-magnetic-field-gamma-ray-observations-blazars','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1354847-constraints-intergalactic-magnetic-field-gamma-ray-observations-blazars"><span>CONSTRAINTS ON THE INTERGALACTIC MAGNETIC FIELD WITH GAMMA-RAY OBSERVATIONS OF BLAZARS</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Finke, Justin D.; Reyes, Luis C.; Georganopoulos, Markos; ...</p> <p>2015-11-12</p> <p>Distant BL Lacertae objects emit γ rays which interact with the extragalactic background light (EBL), creating <span class="hlt">electron</span>-positron pairs, and reducing the <span class="hlt">flux</span> measured by ground-based imaging atmospheric Cherenkov telescopes (IACTs) at very-high energies (VHE). These pairs can Comptonscatter the cosmic microwave background, creating a γ-ray signature at slightly lower energies observable by the Fermi Large Area Telescope (<span class="hlt">LAT</span>). This signal is strongly dependent on the intergalactic magnetic field (IGMF) strength (B) and its coherence length (LB). We use IACT spectra taken from the literature for 5 VHE-detected BL Lac objects, and combine it with <span class="hlt">LAT</span> spectra for these sources tomore » constrain these IGMF parameters. Low B values can be ruled out by the constraint that the cascade <span class="hlt">flux</span> cannot exceed that observed by the <span class="hlt">LAT</span>. High values of B can be ruled out from the constraint that the EBL-deabsorbed IACT spectrum cannot be greater than the <span class="hlt">LAT</span> spectrum extrapolated into the VHE band, unless the cascade spectrum contributes a sizable fraction of the <span class="hlt">LAT</span> <span class="hlt">flux</span>. We rule out low B values (B . 10 -19 G for LB ≥ 1 Mpc) at > 5σ in all trials with different EBL models and data selection, except when« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27237470','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27237470"><span>Chemical potential and reaction <span class="hlt">electronic</span> <span class="hlt">flux</span> in symmetry controlled reactions.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Vogt-Geisse, Stefan; Toro-Labbé, Alejandro</p> <p>2016-07-15</p> <p>In symmetry controlled reactions, orbital degeneracies among orbitals of different symmetries can occur along a reaction coordinate. In such case Koopmans' theorem and the finite difference approximation provide a chemical potential profile with nondifferentiable points. This results in an ill-defined reaction <span class="hlt">electronic</span> <span class="hlt">flux</span> (REF) profile, since it is defined as the derivative of the chemical potential with respect to the reaction coordinate. To overcome this deficiency, we propose a new way for the calculation of the chemical potential based on a many orbital approach, suitable for reactions in which symmetry is preserved. This new approach gives rise to a new descriptor: symmetry adapted chemical potential (SA-CP), which is the chemical potential corresponding to a given irreducible representation of a symmetry group. A corresponding symmetry adapted reaction <span class="hlt">electronic</span> <span class="hlt">flux</span> (SA-REF) is also obtained. Using this approach smooth chemical potential profiles and well defined REFs are achieved. An application of SA-CP and SA-REF is presented by studying the Cs enol-keto tautomerization of thioformic acid. Two SA-REFs are obtained, JA'(ξ) and JA'' (ξ). It is found that the tautomerization proceeds via an in-plane delocalized 3-center 4-<span class="hlt">electron</span> O-H-S hypervalent bond which is predicted to exist only in the transition state (TS) region. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015AGUFMSM51A2518S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015AGUFMSM51A2518S"><span>Calibrating MMS <span class="hlt">Electron</span> Drift Instrument (EDI) Ambient <span class="hlt">Electron</span> <span class="hlt">Flux</span> Measurements and Characterizing 3D Electric Field Signatures of Magnetic Reconnection</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Shuster, J. R.; Torbert, R. B.; Vaith, H.; Argall, M. R.; Li, G.; Chen, L. J.; Ergun, R. E.; Lindqvist, P. A.; Marklund, G. T.; Khotyaintsev, Y. V.; Russell, C. T.; Magnes, W.; Le Contel, O.; Pollock, C. J.; Giles, B. L.</p> <p>2015-12-01</p> <p>The <span class="hlt">electron</span> drift instruments (EDIs) onboard each MMS spacecraft are designed with large geometric factors (~0.01cm2 str) to facilitate detection of weak (~100 nA) <span class="hlt">electron</span> beams fired and received by the two gun-detector units (GDUs) when EDI is in its "electric field mode" to determine the local electric and magnetic fields. A consequence of the large geometric factor is that "ambient mode" <span class="hlt">electron</span> <span class="hlt">flux</span> measurements (500 eV <span class="hlt">electrons</span> having 0°, 90°, or 180° pitch angle) can vary depending on the orientation of the EDI instrument with respect to the magnetic field, a nonphysical effect that requires a correction. Here, we present determinations of the θ- and ø-dependent correction factors for the eight EDI GDUs, where θ (ø) is the polar (azimuthal) angle between the GDU symmetry axis and the local magnetic field direction, and compare the corrected <span class="hlt">fluxes</span> with those measured by the fast plasma instrument (FPI). Using these corrected, high time resolution (~1,000 samples per second) ambient <span class="hlt">electron</span> <span class="hlt">fluxes</span>, combined with the unprecedentedly high resolution 3D electric field measurements taken by the spin-plane and axial double probes (SDP and ADP), we are equipped to accurately detect <span class="hlt">electron</span>-scale current layers and electric field waves associated with the non-Maxwellian (anisotropic and agyrotropic) particle distribution functions predicted to exist in the reconnection diffusion region. We compare initial observations of the diffusion region with distributions and wave analysis from PIC simulations of asymmetric reconnection applicable for modeling reconnection at the Earth's magnetopause, where MMS will begin Science Phase 1 as of September 1, 2015.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li class="active"><span>10</span></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_10 --> <div id="page_11" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li class="active"><span>11</span></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="201"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20120016756','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20120016756"><span>Limits on Large Extra Dimensions Based on Observations of Neutron Stars with the Fermi-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ferrara, E. C.; Scargle, J. D.; Troja, E.</p> <p>2012-01-01</p> <p>We present limits for the compactification scale in the theory of Large Extra Dimensions (LED) proposed by Arkani-Hamed, Dimopoulos, and Dvali. We use 11 months of data from the Fermi Large Area Telescope (Fermi-<span class="hlt">LAT</span>) to set gamma ray <span class="hlt">flux</span> limits for 6 gamma-ray faint neutron stars (NS). To set limits on LED we use the model of Hannestad and Raffelt (HR) that calculates the Kaluza-Klein (KK) graviton production in supernova cores and the large fraction subsequently gravitationally bound around the resulting NS. The predicted decay of the bound KK gravitons to should contribute to the <span class="hlt">flux</span> from NSs. Considering 2 to 7 extra dimensions of the same size in the context of the HR model, we use Monte Carlo techniques to calculate the expected differential <span class="hlt">flux</span> of gamma-rays arising from these KK gravitons, including the effects of the age of the NS, graviton orbit, and absorption of gamma-rays in the magnetosphere of the NS. We compare our Monte Carlo-based differential <span class="hlt">flux</span> to the experimental differential <span class="hlt">flux</span> using maximum likelihood techniques to obtain our limits on LED. Our limits are more restrictive than past EGRET-based optimistic limits that do not include these important corrections. Additionally, our limits are more stringent than LHC based limits for 3 or fewer LED, and comparable for 4 LED. We conclude that if the effective Planck scale is around a TeV, then for 2 or 3 LED the compactification topology must be more complicated than a torus.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1049752','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1049752"><span>Limits on Large Extra Dimensions Based on Observations of Neutron Stars with the Fermi-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Ajello, M.; /SLAC /KIPAC, Menlo Park; Baldini, L.</p> <p></p> <p>We present limits for the compactification scale in the theory of Large Extra Dimensions (LED) proposed by Arkani-Hamed, Dimopoulos, and Dvali. We use 11 months of data from the Fermi Large Area Telescope (Fermi-<span class="hlt">LAT</span>) to set gamma ray <span class="hlt">flux</span> limits for 6 gamma-ray faint neutron stars (NS). To set limits on LED we use the model of Hannestad and Raffelt (HR) that calculates the Kaluza-Klein (KK) graviton production in supernova cores and the large fraction subsequently gravitationally bound around the resulting NS. The predicted decay of the bound KK gravitons to {gamma}{gamma} should contribute to the <span class="hlt">flux</span> from NSs. Consideringmore » 2 to 7 extra dimensions of the same size in the context of the HR model, we use Monte Carlo techniques to calculate the expected differential <span class="hlt">flux</span> of gamma-rays arising from these KK gravitons, including the effects of the age of the NS, graviton orbit, and absorption of gamma-rays in the magnetosphere of the NS. We compare our Monte Carlo-based differential <span class="hlt">flux</span> to the experimental differential <span class="hlt">flux</span> using maximum likelihood techniques to obtain our limits on LED. Our limits are more restrictive than past EGRET-based optimistic limits that do not include these important corrections. Additionally, our limits are more stringent than LHC based limits for 3 or fewer LED, and comparable for 4 LED. We conclude that if the effective Planck scale is around a TeV, then for 2 or 3 LED the compactification topology must be more complicated than a torus.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22279743-limits-large-extra-dimensions-based-observations-neutron-stars-fermi-lat','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22279743-limits-large-extra-dimensions-based-observations-neutron-stars-fermi-lat"><span>Limits on large extra dimensions based on observations of neutron stars with the Fermi-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Ajello, M.; Bechtol, K.; Berenji, B.</p> <p></p> <p>We present limits for the compactification scale in the theory of Large Extra Dimensions (LED) proposed by Arkani-Hamed, Dimopoulos, and Dvali. We use 11 months of data from the Fermi Large Area Telescope (Fermi-<span class="hlt">LAT</span>) to set gamma ray <span class="hlt">flux</span> limits for 6 gamma-ray faint neutron stars (NS). To set limits on LED we use the model of Hannestad and Raffelt (HR) that calculates the Kaluza-Klein (KK) graviton production in supernova cores and the large fraction subsequently gravitationally bound around the resulting NS. The predicted decay of the bound KK gravitons to γγ should contribute to the <span class="hlt">flux</span> from NSs. Consideringmore » 2 to 7 extra dimensions of the same size in the context of the HR model, we use Monte Carlo techniques to calculate the expected differential <span class="hlt">flux</span> of gamma-rays arising from these KK gravitons, including the effects of the age of the NS, graviton orbit, and absorption of gamma-rays in the magnetosphere of the NS. We compare our Monte Carlo-based differential <span class="hlt">flux</span> to the experimental differential <span class="hlt">flux</span> using maximum likelihood techniques to obtain our limits on LED. Our limits are more restrictive than past EGRET-based optimistic limits that do not include these important corrections. Additionally, our limits are more stringent than LHC based limits for 3 or fewer LED, and comparable for 4 LED. We conclude that if the effective Planck scale is around a TeV, then for 2 or 3 LED the compactification topology must be more complicated than a torus.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1356765-limits-large-extra-dimensions-based-observations-neutron-stars-fermi-lat','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1356765-limits-large-extra-dimensions-based-observations-neutron-stars-fermi-lat"><span>Limits on large extra dimensions based on observations of neutron stars with the Fermi-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Ajello, M.</p> <p>2012-02-01</p> <p>We present limits for the compactification scale in the theory of Large Extra Dimensions (LED) proposed by Arkani-Hamed, Dimopoulos, and Dvali. We use 11 months of data from the Fermi Large Area Telescope (Fermi-<span class="hlt">LAT</span>) to set gamma ray <span class="hlt">flux</span> limits for 6 gamma-ray faint neutron stars (NS). To set limits on LED we use the model of Hannestad and Raffelt (HR) that calculates the Kaluza-Klein (KK) graviton production in supernova cores and the large fraction subsequently gravitationally bound around the resulting NS. The predicted decay of the bound KK gravitons to γγ should contribute to the <span class="hlt">flux</span> from NSs. Consideringmore » 2 to 7 extra dimensions of the same size in the context of the HR model, we use Monte Carlo techniques to calculate the expected differential <span class="hlt">flux</span> of gamma-rays arising from these KK gravitons, including the effects of the age of the NS, graviton orbit, and absorption of gamma-rays in the magnetosphere of the NS. We compare our Monte Carlo-based differential <span class="hlt">flux</span> to the experimental differential <span class="hlt">flux</span> using maximum likelihood techniques to obtain our limits on LED. Our limits are more restrictive than past EGRET-based optimistic limits that do not include these important corrections. Additionally, our limits are more stringent than LHC based limits for 3 or fewer LED, and comparable for 4 LED. We conclude that if the effective Planck scale is around a TeV, then for 2 or 3 LED the compactification topology must be more complicated than a torus.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4018440','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4018440"><span>Cerebral Cortex Hyperthyroidism of Newborn Mct8-Deficient Mice Transiently Suppressed by <span class="hlt">Lat</span>2 Inactivation</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Núñez, Bárbara; Martínez de Mena, Raquel; Obregon, Maria Jesus; Font-Llitjós, Mariona; Nunes, Virginia; Palacín, Manuel; Dumitrescu, Alexandra M.; Morte, Beatriz; Bernal, Juan</p> <p>2014-01-01</p> <p>Thyroid hormone entry into cells is facilitated by transmembrane transporters. Mutations of the specific thyroid hormone transporter, MCT8 (Monocarboxylate Transporter 8, SLC16A2) cause an X-linked syndrome of profound neurological impairment and altered thyroid function known as the Allan-Herndon-Dudley syndrome. MCT8 deficiency presumably results in failure of thyroid hormone to reach the neural target cells in adequate amounts to sustain normal brain development. However during the perinatal period the absence of Mct8 in mice induces a state of cerebral cortex hyperthyroidism, indicating increased brain access and/or retention of thyroid hormone. The contribution of other transporters to thyroid hormone metabolism and action, especially in the context of MCT8 deficiency is not clear. We have analyzed the role of the heterodimeric aminoacid transporter <span class="hlt">Lat</span>2 (Slc7a8), in the presence or absence of Mct8, on thyroid hormone concentrations and on expression of thyroid hormone-dependent cerebral cortex genes. To this end we generated <span class="hlt">Lat</span>2-/-, and Mct8-/y<span class="hlt">Lat</span>2 -/- mice, to compare with wild type and Mct8-/y mice during postnatal development. As described previously the single Mct8 KO neonates had a transient increase of 3,5,3′-triiodothyronine concentration and expression of thyroid hormone target genes in the cerebral cortex. Strikingly the absence of <span class="hlt">Lat</span>2 in the double Mct8<span class="hlt">Lat</span>2 KO prevented the effect of Mct8 inactivation in newborns. The <span class="hlt">Lat</span>2 effect was not observed from postnatal day 5 onwards. On postnatal day 21 the Mct8 KO displayed the typical pattern of thyroid hormone concentrations in plasma, decreased cortex 3,5,3′-triiodothyronine concentration and Hr expression, and concomitant <span class="hlt">Lat</span>2 inactivation produced little to no modifications. As <span class="hlt">Lat</span>2 is expressed in neurons and in the choroid plexus, the results support a role for <span class="hlt">Lat</span>2 in the supply of thyroid hormone to the cerebral cortex during early postnatal development. PMID:24819605</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24819605','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24819605"><span>Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by <span class="hlt">lat</span>2 inactivation.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Núñez, Bárbara; Martínez de Mena, Raquel; Obregon, Maria Jesus; Font-Llitjós, Mariona; Nunes, Virginia; Palacín, Manuel; Dumitrescu, Alexandra M; Morte, Beatriz; Bernal, Juan</p> <p>2014-01-01</p> <p>Thyroid hormone entry into cells is facilitated by transmembrane transporters. Mutations of the specific thyroid hormone transporter, MCT8 (Monocarboxylate Transporter 8, SLC16A2) cause an X-linked syndrome of profound neurological impairment and altered thyroid function known as the Allan-Herndon-Dudley syndrome. MCT8 deficiency presumably results in failure of thyroid hormone to reach the neural target cells in adequate amounts to sustain normal brain development. However during the perinatal period the absence of Mct8 in mice induces a state of cerebral cortex hyperthyroidism, indicating increased brain access and/or retention of thyroid hormone. The contribution of other transporters to thyroid hormone metabolism and action, especially in the context of MCT8 deficiency is not clear. We have analyzed the role of the heterodimeric aminoacid transporter <span class="hlt">Lat</span>2 (Slc7a8), in the presence or absence of Mct8, on thyroid hormone concentrations and on expression of thyroid hormone-dependent cerebral cortex genes. To this end we generated <span class="hlt">Lat</span>2-/-, and Mct8-/y<span class="hlt">Lat</span>2-/- mice, to compare with wild type and Mct8-/y mice during postnatal development. As described previously the single Mct8 KO neonates had a transient increase of 3,5,3'-triiodothyronine concentration and expression of thyroid hormone target genes in the cerebral cortex. Strikingly the absence of <span class="hlt">Lat</span>2 in the double Mct8<span class="hlt">Lat</span>2 KO prevented the effect of Mct8 inactivation in newborns. The <span class="hlt">Lat</span>2 effect was not observed from postnatal day 5 onwards. On postnatal day 21 the Mct8 KO displayed the typical pattern of thyroid hormone concentrations in plasma, decreased cortex 3,5,3'-triiodothyronine concentration and Hr expression, and concomitant <span class="hlt">Lat</span>2 inactivation produced little to no modifications. As <span class="hlt">Lat</span>2 is expressed in neurons and in the choroid plexus, the results support a role for <span class="hlt">Lat</span>2 in the supply of thyroid hormone to the cerebral cortex during early postnatal development.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24727689','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24727689"><span>Observation of the magnetic <span class="hlt">flux</span> and three-dimensional structure of skyrmion lattices by <span class="hlt">electron</span> holography.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Park, Hyun Soon; Yu, Xiuzhen; Aizawa, Shinji; Tanigaki, Toshiaki; Akashi, Tetsuya; Takahashi, Yoshio; Matsuda, Tsuyoshi; Kanazawa, Naoya; Onose, Yoshinori; Shindo, Daisuke; Tonomura, Akira; Tokura, Yoshinori</p> <p>2014-05-01</p> <p>Skyrmions are nanoscale spin textures that are viewed as promising candidates as information carriers in future spintronic devices. Skyrmions have been observed using neutron scattering and microscopy techniques. Real-space imaging using <span class="hlt">electrons</span> is a straightforward way to interpret spin configurations by detecting the phase shifts due to electromagnetic fields. Here, we report the first observation by <span class="hlt">electron</span> holography of the magnetic <span class="hlt">flux</span> and the three-dimensional spin configuration of a skyrmion lattice in Fe(0.5)Co(0.5)Si thin samples. The magnetic <span class="hlt">flux</span> inside and outside a skyrmion was directly visualized and the handedness of the magnetic <span class="hlt">flux</span> flow was found to be dependent on the direction of the applied magnetic field. The <span class="hlt">electron</span> phase shifts φ in the helical and skyrmion phases were determined using samples with a stepped thickness t (from 55 nm to 510 nm), revealing a linear relationship (φ = 0.00173 t). The phase measurements were used to estimate the three-dimensional structures of both the helical and skyrmion phases, demonstrating that <span class="hlt">electron</span> holography is a useful tool for studying complex magnetic structures and for three-dimensional, real-space mapping of magnetic fields.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014PhRvD..90d3508L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014PhRvD..90d3508L"><span>Fitting the Fermi-<span class="hlt">LAT</span> GeV excess: On the importance of including the propagation of <span class="hlt">electrons</span> from dark matter</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Lacroix, Thomas; BÅ`hm, Céline; Silk, Joseph</p> <p>2014-08-01</p> <p>An excess of gamma rays at GeV energies has been pointed out in the Fermi-<span class="hlt">LAT</span> data. This signal comes from a narrow region centred around the Galactic center and has been interpreted as possible evidence for light dark matter particles annihilating either into a mixture of leptons-antileptons and bb ¯ or into bb ¯ only. Focusing on the prompt gamma-ray emission, previous works found that the best fit to the data corresponds to annihilations proceeding predominantly into bb ¯. However, here we show that omitting the photon emission originating from primary and secondary <span class="hlt">electrons</span> produced in dark matter annihilations, and undergoing diffusion through the Galactic magnetic field, can actually lead to the wrong conclusion. Accounting for this emission, we find that not only are annihilations of ˜10 GeV particles into a purely leptonic final state allowed, but the democratic scenario actually provides a better fit to the spectrum of the excess than the pure bb ¯ channel. We conclude our work with a discussion on constraints on these leptophilic scenarios based on the AMS data and the morphology of the excess.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1045803','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1045803"><span>Search for Spatially Extended Fermi-<span class="hlt">LAT</span> Sources Using Two Years of Data</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Lande, Joshua; Ackermann, Markus; Allafort, Alice</p> <p>2012-07-13</p> <p>Spatial extension is an important characteristic for correctly associating {gamma}-ray-emitting sources with their counterparts at other wavelengths and for obtaining an unbiased model of their spectra. We present a new method for quantifying the spatial extension of sources detected by the Large Area Telescope (<span class="hlt">LAT</span>), the primary science instrument on the Fermi Gamma-ray Space Telescope (Fermi). We perform a series of Monte Carlo simulations to validate this tool and calculate the <span class="hlt">LAT</span> threshold for detecting the spatial extension of sources. We then test all sources in the second Fermi -<span class="hlt">LAT</span> catalog (2FGL) for extension. We report the detection of sevenmore » new spatially extended sources.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19750049989&hterms=MONITORING+ELECTRONIC&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3DMONITORING%2BELECTRONIC','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19750049989&hterms=MONITORING+ELECTRONIC&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3DMONITORING%2BELECTRONIC"><span>Automatic solar image motion measurements. [<span class="hlt">electronic</span> disk <span class="hlt">flux</span> monitoring</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Colgate, S. A.; Moore, E. P.</p> <p>1975-01-01</p> <p>The solar seeing image motion has been monitored <span class="hlt">electronically</span> and absolutely with a 25 cm telescope at three sites along the ridge at the southern end of the Magdalena Mountains west of Socorro, New Mexico. The uncorrelated component of the variations of the optical <span class="hlt">flux</span> from two points at opposite limbs of the solar disk was continually monitored in 3 frequencies centered at 0.3, 3 and 30 Hz. The frequency band of maximum signal centered at 3 Hz showed the average absolute value of image motion to be somewhat less than 2sec. The observer estimates of combined blurring and image motion were well correlated with <span class="hlt">electronically</span> measured image motion, but the observer estimates gave a factor 2 larger value.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29610403','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29610403"><span>Cooperation of Antiporter <span class="hlt">LAT</span>2/CD98hc with Uniporter TAT1 for Renal Reabsorption of Neutral Amino Acids.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Vilches, Clara; Boiadjieva-Knöpfel, Emilia; Bodoy, Susanna; Camargo, Simone; López de Heredia, Miguel; Prat, Esther; Ormazabal, Aida; Artuch, Rafael; Zorzano, Antonio; Verrey, François; Nunes, Virginia; Palacín, Manuel</p> <p>2018-04-02</p> <p>Background Reabsorption of amino acids (AAs) across the renal proximal tubule is crucial for intracellular and whole organism AA homeostasis. Although the luminal transport step is well understood, with several diseases caused by dysregulation of this process, the basolateral transport step is not understood. In humans, only cationic aminoaciduria due to malfunction of the basolateral transporter y + <span class="hlt">LAT</span>1/CD98hc (SLC7A7/SLC3A2), which mediates the export of cationic AAs, has been described. Thus, the physiologic roles of basolateral transporters of neutral AAs, such as the antiporter <span class="hlt">LAT</span>2/CD98hc (SLC7A8/SLC3A2), a heterodimer that exports most neutral AAs, and the uniporter TAT1 (SLC16A10), which exports only aromatic AAs, remain unclear. Functional cooperation between TAT1 and <span class="hlt">LAT</span>2/CD98hc has been suggested by in vitro studies but has not been evaluated in vivo Methods To study the functional relationship of TAT1 and <span class="hlt">LAT</span>2/CD98hc in vivo , we generated a double-knockout mouse model lacking TAT1 and <span class="hlt">LAT</span>2, the catalytic subunit of <span class="hlt">LAT</span>2/CD98hc (dKO <span class="hlt">LAT</span>2-TAT1 mice). Results Compared with mice lacking only TAT1 or <span class="hlt">LAT</span>2, dKO <span class="hlt">LAT</span>2-TAT1 mice lost larger amounts of aromatic and other neutral AAs in their urine due to a tubular reabsorption defect. Notably, dKO mice also displayed decreased tubular reabsorption of cationic AAs and increased expression of y + <span class="hlt">LAT</span>1/CD98hc. Conclusions The <span class="hlt">LAT</span>2/CD98hc and TAT1 transporters functionally cooperate in vivo , and y + <span class="hlt">LAT</span>1/CD98hc may compensate for the loss of <span class="hlt">LAT</span>2/CD98hc and TAT1, functioning as a neutral AA exporter at the expense of some urinary loss of cationic AAs. Cooperative and compensatory mechanisms of AA transporters may explain the lack of basolateral neutral aminoacidurias in humans. Copyright © 2018 by the American Society of Nephrology.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20170003140&hterms=energy&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Denergy','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20170003140&hterms=energy&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Denergy"><span><span class="hlt">Electron</span> <span class="hlt">Flux</span> Models for Different Energies at Geostationary Orbit</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Boynton, R. J.; Balikhin, M. A.; Sibeck, D. G.; Walker, S. N.; Billings, S. A.; Ganushkina, N.</p> <p>2016-01-01</p> <p>Forecast models were derived for energetic <span class="hlt">electrons</span> at all energy ranges sampled by the third-generation Geostationary Operational Environmental Satellites (GOES). These models were based on Multi-Input Single-Output Nonlinear Autoregressive Moving Average with Exogenous inputs methodologies. The model inputs include the solar wind velocity, density and pressure, the fraction of time that the interplanetary magnetic field (IMF) was southward, the IMF contribution of a solar wind-magnetosphere coupling function proposed by Boynton et al. (2011b), and the Dst index. As such, this study has deduced five new 1 h resolution models for the low-energy <span class="hlt">electrons</span> measured by GOES (30-50 keV, 50-100 keV, 100-200 keV, 200-350 keV, and 350-600 keV) and extended the existing >800 keV and >2 MeV Geostationary Earth Orbit <span class="hlt">electron</span> <span class="hlt">fluxes</span> models to forecast at a 1 h resolution. All of these models were shown to provide accurate forecasts, with prediction efficiencies ranging between 66.9% and 82.3%.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19008013','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19008013"><span><span class="hlt">LATS</span>2 tumour specific mutations and down-regulation of the gene in non-small cell carcinoma.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Strazisar, Mojca; Mlakar, Vid; Glavac, Damjan</p> <p>2009-06-01</p> <p><span class="hlt">LATS</span>2 is a new member of the <span class="hlt">LATS</span> tumour suppressor family. The human <span class="hlt">LATS</span>2 gene is located at chromosome 13q11-12, a hot spot (67%) for loss of heterozygosity (LOH) in non-small cell lung cancer (NSCLC). We screened 129 non-small cell lung cancer samples and 13 lung cancer cell lines, initially for mutations in the <span class="hlt">LATS</span>2 gene and subsequently for mutations in P53 and K-RAS genes. Either polymorphisms or mutations were identified in over 50 percent of analysed tumours. A novel missense mutation, S1073R, and a large deletion of 8 amino acids in the PAPA-repeat region were detected in 9 and 2 NSCLC tumours, respectively. Those mutations were not identified in the 13 lung cancer cell lines. Mutations were tumour specific and were absent from adjacent normal tissue and healthy controls. Down-regulation of the <span class="hlt">LATS</span>2 gene was observed in most NSCLC tumours but was not related to any mutation or polymorphism. Tumours with a <span class="hlt">LATS</span>2 mutation often also harbour a P53 but not K-RAS gene mutation and were mostly in an advanced stage of development, with regional lymph node involvement.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014AAS...22325127C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014AAS...22325127C"><span>Five Years of the Fermi <span class="hlt">LAT</span> Flare Advocate</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Carpenter, Bryce; Ojha, R.; Gasparrini, D.; Ciprini, S.; Fermi LAT Collaboration; Fermi LAT Flare Advocates</p> <p>2014-01-01</p> <p>Since the launch of the Fermi satellite, the Fermi Large Area Telescope (<span class="hlt">LAT</span>) team has run a program that provides a daily review of the the gamma-ray sky as soon as Fermi <span class="hlt">LAT</span> data becomes available. The Flare Advocate/Gamma-ray Sky Watcher (FA-GSW) program allows a rapid analysis of the Automatic Science Processing (ASP) products and triggers dedicated followup analyses by several <span class="hlt">LAT</span> science groups such as those studying Galactic transients, extragalactic sources and new gamma-ray sources. Significant gamma-ray detections also trigger rapid communications to the entire astrophysical community via astronomical telegrams and gamma-ray coordination network notices. The FA-GSW program plays a key role in maximizing the science return from Fermi by increasing the rate of multi-frequency observations of sources in an active gamma-ray state. In the past ~5 years blazar flaring activity of varying strength and duty cycles, gravitationally lensed blazars, flares from Galactic sources (like Nova Delphini and the Crab Nebula), unidentified transients near and off the Galactic plane, and emission from the quiet and flaring Sun, represent the range of detections made. Flare Advocates have published about 250 Astronomical Telegrams and they publish a weekly blog. Timely, extensive multi-frequency campaigns have been organized to follow-up on these phenomena leading to some of Fermi’s most interesting results.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17178387','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17178387"><span>Trichostatin A down-regulates ZAP-70, <span class="hlt">LAT</span> and SLP-76 content in Jurkat T cells.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Januchowski, Radosław; Jagodzinski, Paweł P</p> <p>2007-02-01</p> <p>We exploited Jurkat leukemia T cell clone E6-1 as a model of Trichostatin A (TSA) effect on cellular levels of ZAP-70, <span class="hlt">LAT</span> and SLP-76 molecules involved in the signal transduction pathway from T cell receptor to nucleus. Using reverse transcription real-time quantitative PCR and Western blotting analysis we observed that TSA resulted in ZAP-70, <span class="hlt">LAT</span> and SLP-76 transcript and protein down-regulation in Jurkat leukemia T cells. We also found that TSA reduced half-life of ZAP-70, <span class="hlt">LAT</span> and SLP-76 mRNAs from 4.8, 3.5, and 4.8 to approximately 2.3, 1.9 and 1.7 h, respectively. Employing the protein biosynthesis inhibitor cycloheximide, we demonstrated the involvement of RNase and/or mRNA stabilization protein in ZAP-70, <span class="hlt">LAT</span> and SLP-76 mRNAs stabilization. The effect of TSA on ZAP-70, <span class="hlt">LAT</span> and SLP-76 content in T cells confirms an immunosuppressive effect by TSA, and the usefulness of this histone deacetylase inhibitor in the treatment of autoimmune diseases.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1258662-first-fermi-lat-supernova-remnant-catalog','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1258662-first-fermi-lat-supernova-remnant-catalog"><span>The first Fermi <span class="hlt">LAT</span> supernova remnant catalog</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Acero, F.</p> <p>2016-05-16</p> <p>To uniformly determine the properties of supernova remnants (SNRs) at high energies, we have developed the first systematic survey at energies from 1 to 100 GeV using data from the Fermi Large Area Telescope. Based on the spatial overlap of sources detected at GeV energies with SNRs known from radio surveys, we classify 30 sources as likely GeV SNRs. We also report 14 marginal associations and 245 <span class="hlt">flux</span> upper limits. A mock catalog in which the positions of known remnants are scrambled in Galactic longitude, allows us to determine an upper limit of 22% on the number of GeV candidatesmore » falsely identified as SNRs. We have also developed a method to estimate spectral and spatial systematic errors arising from the diffuse interstellar emission model, a key component of all Galactic Fermi <span class="hlt">LAT</span> analyses. By studying remnants uniformly in aggregate, we measure the GeV properties common to these objects and provide a crucial context for the detailed modeling of individual SNRs. Combining our GeV results with multiwavelength (MW) data, including radio, X-ray, and TeV, demonstrates the need for improvements to previously sufficient, simple models describing the GeV and radio emission from these objects. As a result, we model the GeV and MW emission from SNRs in aggregate to constrain their maximal contribution to observed Galactic cosmic rays.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014A%26A...562A.145H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014A%26A...562A.145H"><span>Search for extended γ-ray emission around AGN with H.E.S.S. and Fermi-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>H. E. S. S. Collaboration; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Angüner, E.; Anton, G.; Backes, M.; Balenderan, S.; Balzer, A.; Barnacka, A.; Becherini, Y.; Becker Tjus, J.; Bernlöhr, K.; Birsin, E.; Bissaldi, E.; Biteau, J.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Brucker, J.; Brun, F.; Brun, P.; Bulik, T.; Carrigan, S.; Casanova, S.; Chadwick, P. M.; Chalme-Calvet, R.; Chaves, R. C. G.; Cheesebrough, A.; Chrétien, M.; Colafrancesco, S.; Cologna, G.; Conrad, J.; Couturier, C.; Cui, Y.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; deWilt, P.; Dickinson, H. J.; Djannati-Atäı, A.; Domainko, W.; Drury, L. O'C.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Edwards, T.; Egberts, K.; Eger, P.; Espigat, P.; Farnier, C.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fernandez, D.; Fiasson, A.; Fontaine, G.; Förster, A.; Füßling, M.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Grondin, M.-H.; Grudzińska, M.; Häffner, S.; Hahn, J.; Harris, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Holler, M.; Horns, D.; Jacholkowska, A.; Jahn, C.; Jamrozy, M.; Janiak, M.; Jankowsky, F.; Jung, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kaufmann, S.; Khélifi, B.; Kieffer, M.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kneiske, T.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Krayzel, F.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lefaucheur, J.; Lemie`re, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; McComb, T. J. L.; Méhault, J.; Meintjes, P. J.; Menzler, U.; Meyer, M.; Moderski, R.; Mohamed, M.; Moulin, E.; Murach, T.; Naumann, C. L.; de Naurois, M.; Niemiec, J.; Nolan, S. J.; Oakes, L.; Odaka, H.; Ohm, S.; de Oña Wilhelmi, E.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perez, J.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Poon, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Raue, M.; Reichardt, I.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Rob, L.; Romoli, C.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Sanchez, D. A.; Santangelo, A.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Sol, H.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tluczykont, M.; Trichard, C.; Valerius, K.; van Eldik, C.; van Soelen, B.; Vasileiadis, G.; Venter, C.; Viana, A.; Vincent, P.; Völk, H. J.; Volpe, F.; Vorster, M.; Vuillaume, T.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; Ward, M.; Weidinger, M.; Weitzel, Q.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zacharias, M.; Zdziarski, A. A.; Zech, A.; Zechlin, H.-S.; Malyshev, D.</p> <p>2014-02-01</p> <p>Context. Very-high-energy (VHE; E > 100 GeV) γ-ray emission from blazars inevitably gives rise to <span class="hlt">electron</span>-positron pair production through the interaction of these γ-rays with the extragalactic background light (EBL). Depending on the magnetic fields in the proximity of the source, the cascade initiated from pair production can result in either an isotropic halo around an initially beamed source or a magnetically broadened cascade <span class="hlt">flux</span>. Aims: Both extended pair-halo (PH) and magnetically broadened cascade (MBC) emission from regions surrounding the blazars 1ES 1101-232, 1ES 0229+200, and PKS 2155-304 were searched for using VHE γ-ray data taken with the High Energy Stereoscopic System (H.E.S.S.) and high-energy (HE; 100 MeV < E < 100 GeV) γ-ray data with the Fermi Large Area Telescope (<span class="hlt">LAT</span>). Methods: By comparing the angular distributions of the reconstructed γ-ray events to the angular profiles calculated from detailed theoretical models, the presence of PH and MBC was investigated. Results: Upper limits on the extended emission around 1ES 1101-232, 1ES 0229+200, and PKS 2155-304 are found to be at a level of a few per cent of the Crab nebula <span class="hlt">flux</span> above 1 TeV, depending on the assumed photon index of the cascade emission. Assuming strong extra-Galactic magnetic field (EGMF) values, >10-12 G, this limits the production of pair haloes developing from electromagnetic cascades. For weaker magnetic fields, in which electromagnetic cascades would result in MBCs, EGMF strengths in the range (0.3-3)× 10-15 G were excluded for PKS 2155-304 at the 99% confidence level, under the assumption of a 1 Mpc coherence length.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5114644','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5114644"><span>High <span class="hlt">flux</span> circularly polarized gamma beam factory: coupling a Fabry-Perot optical cavity with an <span class="hlt">electron</span> storage ring</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Chaikovska, I.; Cassou, K.; Chiche, R.; Cizeron, R.; Cornebise, P.; Delerue, N.; Jehanno, D.; Labaye, F.; Marie, R.; Martens, A.; Peinaud, Y.; Soskov, V.; Variola, A.; Zomer, F.; Cormier, E.; Lhermite, J.; Dolique, V.; Flaminio, R.; Michel, C.; Pinard, L.; Sassolas, B.; Akagi, T.; Araki, S.; Honda, Y.; Omori, T.; Terunuma, N.; Urakawa, J.; Miyoshi, S.; Takahashi, T.; Yoshitama, H.</p> <p>2016-01-01</p> <p>We report and discuss high-<span class="hlt">flux</span> generation of circularly polarized γ-rays by means of Compton scattering. The γ-ray beam results from the collision of an external-cavity-enhanced infrared laser beam and a low emittance relativistic <span class="hlt">electron</span> beam. By operating a non-planar bow-tie high-finesse optical Fabry-Perot cavity coupled to a storage ring, we have recorded a <span class="hlt">flux</span> of up to (3.5 ± 0.3) × 108 photons per second with a mean measured energy of 24 MeV. The γ-ray <span class="hlt">flux</span> has been sustained for several hours. In particular, we were able to measure a record value of up to 400 γ-rays per collision in a full bandwidth. Moreover, the impact of Compton scattering on the <span class="hlt">electron</span> beam dynamics could be observed resulting in a reduction of the <span class="hlt">electron</span> beam lifetime correlated to the laser power stored in the Fabry-Perot cavity. We demonstrate that the <span class="hlt">electron</span> beam lifetime provides an independent and consistent determination of the γ-ray <span class="hlt">flux</span>. Furthermore, a reduction of the γ-ray <span class="hlt">flux</span> due to intrabeam scattering has clearly been identified. These results, obtained on an accelerator test facility, warrant potential scaling and revealed both expected and yet unobserved effects. They set the baseline for further scaling of the future Compton sources under development around the world. PMID:27857146</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015ApJ...814...20F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015ApJ...814...20F"><span>Constraints on the Intergalactic Magnetic Field with Gamma-Ray Observations of Blazars</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Finke, Justin D.; Reyes, Luis C.; Georganopoulos, Markos; Reynolds, Kaeleigh; Ajello, Marco; Fegan, Stephen J.; McCann, Kevin</p> <p>2015-11-01</p> <p>Distant BL Lacertae objects emit γ-rays that interact with the extragalactic background light (EBL), creating <span class="hlt">electron</span>-positron pairs, and reducing the <span class="hlt">flux</span> measured by ground-based imaging atmospheric Cherenkov telescopes (IACTs) at very-high energies (VHE). These pairs can Compton-scatter the cosmic microwave background, creating a γ-ray signature at slightly lower energies that is observable by the Fermi Large Area Telescope (<span class="hlt">LAT</span>). This signal is strongly dependent on the intergalactic magnetic field (IGMF) strength (B) and its coherence length (LB). We use IACT spectra taken from the literature for 5 VHE-detected BL Lac objects and combine them with <span class="hlt">LAT</span> spectra for these sources to constrain these IGMF parameters. Low B values can be ruled out by the constraint that the cascade <span class="hlt">flux</span> cannot exceed that observed by the <span class="hlt">LAT</span>. High values of B can be ruled out from the constraint that the EBL-deabsorbed IACT spectrum cannot be greater than the <span class="hlt">LAT</span> spectrum extrapolated into the VHE band, unless the cascade spectrum contributes a sizable fraction of the <span class="hlt">LAT</span> <span class="hlt">flux</span>. We rule out low B values (B ≲ 10-19 G for LB ≥ 1 Mpc) at >5σ in all trials with different EBL models and data selection, except when using >1 GeV spectra and the lowest EBL models. We were not able to constrain high values of B.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20140005254','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20140005254"><span>Constraints on the Galactic Halo Dark Matter from Fermi-<span class="hlt">LAT</span> Diffuse Measurements</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ackermann, M.; Ajello, M.; Atwood, W. B.; Baldini, L.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Blandford, R. D.; Bloom, E. D.; <a style="text-decoration: none; " href="javascript:void(0); " onClick="displayelement('author_20140005254'); toggleEditAbsImage('author_20140005254_show'); toggleEditAbsImage('author_20140005254_hide'); "> <img style="display:inline; width:12px; height:12px; " src="images/arrow-up.gif" width="12" height="12" border="0" alt="hide" id="author_20140005254_show"> <img style="width:12px; height:12px; display:none; " src="images/arrow-down.gif" width="12" height="12" border="0" alt="hide" id="author_20140005254_hide"></p> <p>2012-01-01</p> <p>We have performed an analysis of the diffuse gamma-ray emission with the Fermi Large Area Telescope (<span class="hlt">LAT</span>) in the Milky Way halo region, searching for a signal from dark matter annihilation or decay. In the absence of a robust dark matter signal, constraints are presented. We consider both gamma rays produced directly in the dark matter annihilation/decay and produced by inverse Compton scattering of the e+/e- produced in the annihilation/decay. Conservative limits are derived requiring that the dark matter signal does not exceed the observed diffuse gamma-ray emission. A second set of more stringent limits is derived based on modeling the foreground astrophysical diffuse emission using the GALPROP code. Uncertainties in the height of the diffusive cosmic-ray halo, the distribution of the cosmic-ray sources in the Galaxy, the index of the injection cosmic-ray <span class="hlt">electron</span> spectrum, and the column density of the interstellar gas are taken into account using a profile likelihood formalism, while the parameters governing the cosmic-ray propagation have been derived from fits to local cosmic-ray data. The resulting limits impact the range of particle masses over which dark matter thermal production in the early universe is possible, and challenge the interpretation of the PAMELA/Fermi-<span class="hlt">LAT</span> cosmic ray anomalies as the annihilation of dark matter.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li class="active"><span>11</span></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_11 --> <div id="page_12" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li class="active"><span>12</span></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="221"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1356606-constraints-galactic-halo-dark-matter-from-fermi-lat-diffuse-measurements','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1356606-constraints-galactic-halo-dark-matter-from-fermi-lat-diffuse-measurements"><span>Constraints on the Galactic Halo Dark Matter From FERMI-<span class="hlt">LAT</span> Diffuse Measurements</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Ackermann, M.; Ajello, M.; Atwood, W. B.; ...</p> <p>2012-11-28</p> <p>For this study, we have performed an analysis of the diffuse gamma-ray emission with the Fermi Large Area Telescope (<span class="hlt">LAT</span>) in the Milky Way halo region, searching for a signal from dark matter annihilation or decay. In the absence of a robust dark matter signal, constraints are presented. We consider both gamma rays produced directly in the dark matter annihilation/decay and produced by inverse Compton scattering of the e +/e – produced in the annihilation/decay. Conservative limits are derived requiring that the dark matter signal does not exceed the observed diffuse gamma-ray emission. A second set of more stringent limitsmore » is derived based on modeling the foreground astrophysical diffuse emission using the GALPROP code. Uncertainties in the height of the diffusive cosmic-ray halo, the distribution of the cosmic-ray sources in the Galaxy, the index of the injection cosmic-ray <span class="hlt">electron</span> spectrum, and the column density of the interstellar gas are taken into account using a profile likelihood formalism, while the parameters governing the cosmic-ray propagation have been derived from fits to local cosmic-ray data. In conclusion, the resulting limits impact the range of particle masses over which dark matter thermal production in the early universe is possible, and challenge the interpretation of the PAMELA/Fermi-<span class="hlt">LAT</span> cosmic ray anomalies as the annihilation of dark matter.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018yCat..18190044A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018yCat..18190044A"><span>VizieR Online Data Catalog: First Fermi-<span class="hlt">LAT</span> Inner Galaxy point source catalog (Ajello+, 2016)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ajello, M.; Albert, A.; Atwood, W. B.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Bissaldi, E.; Blandford, R. D.; Bloom, E. D.; Bonino, R.; Bottacini, E.; Brandt, T. J.; Bregeon, J.; Bruel, P.; Buehler, R.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caputo, R.; Caragiulo, M.; Caraveo, P. A.; Cecchi, C.; Chekhtman, A.; Chiang, J.; Chiaro, G.; Ciprini, S.; Cohen-Tanugi, J.; Cominsky, L. R.; Conrad, J.; Cutini, S.; D'Ammando, F.; de Angelis, A.; de Palma, F.; Desiante, R.; di Venere, L.; Drell, P. S.; Favuzzi, C.; Ferrara, E. C.; Fusco, P.; Gargano, F.; Gasparrini, D.; Giglietto, N.; Giommi, P.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Gomez-Vargas, G. A.; Grenier, I. A.; Guiriec, S.; Gustafsson, M.; Harding, A. K.; Hewitt, J. W.; Hill, A. B.; Horan, D.; Jogler, T.; Johannesson, G.; Johnson, A. S.; Kamae, T.; Karwin, C.; Knodlseder, J.; Kuss, M.; Larsson, S.; Latronico, L.; Li, J.; Li, L.; Longo, F.; Loparco, F.; Lovellette, M. N.; Lubrano, P.; Magill, J.; Maldera, S.; Malyshev, D.; Manfreda, A.; Mayer, M.; Mazziotta, M. N.; Michelson, P. F.; Mitthumsiri, W.; Mizuno, T.; Moiseev, A. A.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nuss, E.; Ohno, M.; Ohsugi, T.; Omodei, N.; Orlando, E.; Ormes, J. F.; Paneque, D.; Pesce-Rollins, M.; Piron, F.; Pivato, G.; Porter, T. A.; Raino, S.; Rando, R.; Razzano, M.; Reimer, A.; Reimer, O.; Ritz, S.; Sanchez-Conde, M.; Parkinson, P. M. S.; Sgro, C.; Siskind, E. J.; Smith, D. A.; Spada, F.; Spandre, G.; Spinelli, P.; Suson, D. J.; Tajima, H.; Takahashi, H.; Thayer, J. B.; Torres, D. F.; Tosti, G.; Troja, E.; Uchiyama, Y.; Vianello, G.; Winer, B. L.; Wood, K. S.; Zaharijas, G.; Zimmer, S.</p> <p>2018-01-01</p> <p>The Fermi Large Area Telescope (<span class="hlt">LAT</span>) has provided the most detailed view to date of the emission toward the Galactic center (GC) in high-energy γ-rays. This paper describes the analysis of data taken during the first 62 months of the mission in the energy range 1-100GeV from a 15°x15° region about the direction of the GC. Specialized interstellar emission models (IEMs) are constructed to enable the separation of the γ-ray emissions produced by cosmic ray particles interacting with the interstellar gas and radiation fields in the Milky Way into that from the inner ~1kpc surrounding the GC, and that from the rest of the Galaxy. A catalog of point sources for the 15°x15° region is self-consistently constructed using these IEMs: the First Fermi-<span class="hlt">LAT</span> Inner Galaxy Point Source Catalog (1FIG). The spatial locations, <span class="hlt">fluxes</span>, and spectral properties of the 1FIG sources are presented, and compared with γ-ray point sources over the same region taken from existing catalogs. After subtracting the interstellar emission and point-source contributions a residual is found. If templates that peak toward the GC are used to model the positive residual the agreement with the data improves, but none of the additional templates tried account for all of its spatial structure. The spectrum of the positive residual modeled with these templates has a strong dependence on the choice of IEM. (2 data files).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26795154','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26795154"><span>How high do ion <span class="hlt">fluxes</span> go? A re-evaluation of the two-mechanism model of K(+) transport in plant roots.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Coskun, Devrim; Britto, Dev T; Kochian, Leon V; Kronzucker, Herbert J</p> <p>2016-02-01</p> <p>Potassium (K(+)) acquisition in roots is generally described by a two-mechanism model, consisting of a saturable, high-affinity transport system (HATS) operating via H(+)/K(+) symport at low (<1mM) external [K(+)] ([K(+)]ext), and a linear, low-affinity system (<span class="hlt">LATS</span>) operating via ion channels at high (>1mM) [K(+)]ext. Radiotracer measurements in the <span class="hlt">LATS</span> range indicate that the linear rise in influx continues well beyond nutritionally relevant concentrations (>10mM), suggesting K(+) transport may be pushed to extraordinary, and seemingly limitless, capacity. Here, we assess this rise, asking whether <span class="hlt">LATS</span> measurements faithfully report transmembrane <span class="hlt">fluxes</span>. Using (42)K(+)-isotope and electrophysiological methods in barley, we show that this <span class="hlt">flux</span> is part of a K(+)-transport cycle through the apoplast, and masks a genuine plasma-membrane influx that displays Michaelis-Menten kinetics. Rapid apoplastic cycling of K(+) is corroborated by an absence of transmembrane (42)K(+) efflux above 1mM, and by the efflux kinetics of PTS, an apoplastic tracer. A linear apoplastic influx, masking a saturating transmembrane influx, was also found in Arabidopsis mutants lacking the K(+) transporters AtHAK5 and AtAKT1. Our work significantly revises the model of K(+) transport by demonstrating a surprisingly modest upper limit for plasma-membrane influx, and offers insight into sodium transport under salt stress. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/1434406-high-flux-femtosecond-ray-emission-from-electron-hose-instability-laser-wakefield-accelerators','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/1434406-high-flux-femtosecond-ray-emission-from-electron-hose-instability-laser-wakefield-accelerators"><span>High <span class="hlt">flux</span> femtosecond x-ray emission from the <span class="hlt">electron</span>-hose instability in laser wakefield accelerators</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Dong, C. F.; Zhao, T. Z.; Behm, K.</p> <p></p> <p>Here, bright and ultrashort duration x-ray pulses can be produced by through betatron oscillations of <span class="hlt">electrons</span> during laser wakefield acceleration (LWFA). Our experimental measurements using the Hercules laser system demonstrate a dramatic increase in x-ray <span class="hlt">flux</span> for interaction distances beyond the depletion/dephasing lengths, where the initial <span class="hlt">electron</span> bunch injected into the first wake bucket catches up with the laser pulse front and the laser pulse depletes. A transition from an LWFA regime to a beam-driven plasma wakefield acceleration regime consequently occurs. The drive <span class="hlt">electron</span> bunch is susceptible to the <span class="hlt">electron</span>-hose instability and rapidly develops large amplitude oscillations in its tail,more » which leads to greatly enhanced x-ray radiation emission. We measure the x-ray <span class="hlt">flux</span> as a function of acceleration length using a variable length gas cell. 3D particle-in-cell simulations using a Monte Carlo synchrotron x-ray emission algorithm elucidate the time-dependent variations in the radiation emission processes.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018PhRvS..21d1303D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018PhRvS..21d1303D"><span>High <span class="hlt">flux</span> femtosecond x-ray emission from the <span class="hlt">electron</span>-hose instability in laser wakefield accelerators</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Dong, C. F.; Zhao, T. Z.; Behm, K.; Cummings, P. G.; Nees, J.; Maksimchuk, A.; Yanovsky, V.; Krushelnick, K.; Thomas, A. G. R.</p> <p>2018-04-01</p> <p>Bright and ultrashort duration x-ray pulses can be produced by through betatron oscillations of <span class="hlt">electrons</span> during laser wakefield acceleration (LWFA). Our experimental measurements using the Hercules laser system demonstrate a dramatic increase in x-ray <span class="hlt">flux</span> for interaction distances beyond the depletion/dephasing lengths, where the initial <span class="hlt">electron</span> bunch injected into the first wake bucket catches up with the laser pulse front and the laser pulse depletes. A transition from an LWFA regime to a beam-driven plasma wakefield acceleration regime consequently occurs. The drive <span class="hlt">electron</span> bunch is susceptible to the <span class="hlt">electron</span>-hose instability and rapidly develops large amplitude oscillations in its tail, which leads to greatly enhanced x-ray radiation emission. We measure the x-ray <span class="hlt">flux</span> as a function of acceleration length using a variable length gas cell. 3D particle-in-cell simulations using a Monte Carlo synchrotron x-ray emission algorithm elucidate the time-dependent variations in the radiation emission processes.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1434406-high-flux-femtosecond-ray-emission-from-electron-hose-instability-laser-wakefield-accelerators','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1434406-high-flux-femtosecond-ray-emission-from-electron-hose-instability-laser-wakefield-accelerators"><span>High <span class="hlt">flux</span> femtosecond x-ray emission from the <span class="hlt">electron</span>-hose instability in laser wakefield accelerators</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Dong, C. F.; Zhao, T. Z.; Behm, K.; ...</p> <p>2018-04-24</p> <p>Here, bright and ultrashort duration x-ray pulses can be produced by through betatron oscillations of <span class="hlt">electrons</span> during laser wakefield acceleration (LWFA). Our experimental measurements using the Hercules laser system demonstrate a dramatic increase in x-ray <span class="hlt">flux</span> for interaction distances beyond the depletion/dephasing lengths, where the initial <span class="hlt">electron</span> bunch injected into the first wake bucket catches up with the laser pulse front and the laser pulse depletes. A transition from an LWFA regime to a beam-driven plasma wakefield acceleration regime consequently occurs. The drive <span class="hlt">electron</span> bunch is susceptible to the <span class="hlt">electron</span>-hose instability and rapidly develops large amplitude oscillations in its tail,more » which leads to greatly enhanced x-ray radiation emission. We measure the x-ray <span class="hlt">flux</span> as a function of acceleration length using a variable length gas cell. 3D particle-in-cell simulations using a Monte Carlo synchrotron x-ray emission algorithm elucidate the time-dependent variations in the radiation emission processes.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29695141','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29695141"><span>Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, <span class="hlt">LAT</span>1.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Singh, Natesh; Ecker, Gerhard F</p> <p>2018-04-24</p> <p>The large neutral amino acid transporter 1 (<span class="hlt">LAT</span>1, or SLC7A5) is a sodium- and pH-independent transporter, which supplies essential amino acids (e.g., leucine, phenylalanine) to cells. It plays an important role at the Blood⁻Brain Barrier (BBB) where it facilitates the transport of thyroid hormones, pharmaceuticals (e.g., l-DOPA, gabapentin), and metabolites into the brain. Moreover, its expression is highly upregulated in various types of human cancer that are characterized by an intense demand for amino acids for growth and proliferation. Therefore, <span class="hlt">LAT</span>1 is believed to be an important drug target for cancer treatment. With the crystallization of the arginine/agmatine antiporter (AdiC) from Escherichia Coli , numerous homology models of <span class="hlt">LAT</span>1 have been built to elucidate the substrate binding site, ligand⁻transporter interaction, and structure⁻function relationship. The use of these models in combination with molecular docking and experimental testing has identified novel chemotypes of ligands of <span class="hlt">LAT</span>1. Here, we highlight the structure, function, transport mechanism, and homology modeling of <span class="hlt">LAT</span>1. Additionally, results from structure⁻function studies performed on <span class="hlt">LAT</span>1 are addressed, which have enhanced our knowledge of the mechanism of substrate binding and translocation. This is followed by a discussion on ligand- and structure-based approaches, with an emphasis on elucidating the molecular basis of <span class="hlt">LAT</span>1 inhibition. Finally, we provide an exhaustive summary of different <span class="hlt">LAT</span>1 inhibitors that have been identified so far, including the recently discovered irreversible covalent inhibitors.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19840030076&hterms=ghosts&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dghosts','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19840030076&hterms=ghosts&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dghosts"><span>The Mimas ghost revisited - An analysis of the <span class="hlt">electron</span> <span class="hlt">flux</span> and <span class="hlt">electron</span> microsignatures observed in the vicinity of Mimas at Saturn</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Chenette, D. L.; Stone, E. C.</p> <p>1983-01-01</p> <p>An analysis of the <span class="hlt">electron</span>-absorption signature observed by the cosmic-ray system on Voyager 2 near the orbit of Mimas is presented. It is found that these observations cannot be explained as the absorption signature of Mimas. By combining Pioneer 11 and Voyager 2 measurements of the <span class="hlt">electron</span> <span class="hlt">flux</span> at Mimas's orbit (L = 3.1), an <span class="hlt">electron</span> spectrum is found in which most of the <span class="hlt">flux</span> above about 100 keV is concentrated near 1 to 3 MeV. This spectral form is qualitatively consistent with the bandpass filter model of Van Allen et al. (1980). The expected Mimas absorption signature is calculated from this spectrum neglecting radial diffusion. Since no Mimas absorption signature was observed in the inbound Voyager 2 data, a lower limit on the diffusion coefficient for MeV <span class="hlt">electrons</span> at L = 3.1 of D greater than 10 to the -8th sq Saturn radii/sec is obtained. With a diffusion coefficient this large, both the Voyager 2 and the Pioneer 11 small-scale <span class="hlt">electron</span>-absorption-signature observations in Mimas's orbit are enigmatic. Thus the mechanism for producing these signatures is referred to as the Mimas ghost. A cloud of material in orbit with Mimas may account for the observed <span class="hlt">electron</span> signature if the cloud is at least 1-percent opaque to <span class="hlt">electrons</span> across a region extending over a few hundred kilometers.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25205473','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25205473"><span>Quantitative insight into the design of compounds recognized by the L-type amino acid transporter 1 (<span class="hlt">LAT</span>1).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ylikangas, Henna; Malmioja, Kalle; Peura, Lauri; Gynther, Mikko; Nwachukwu, Emmanuel O; Leppänen, Jukka; Laine, Krista; Rautio, Jarkko; Lahtela-Kakkonen, Maija; Huttunen, Kristiina M; Poso, Antti</p> <p>2014-12-01</p> <p>L-Type amino acid transporter 1 (<span class="hlt">LAT</span>1) is a transmembrane protein expressed abundantly at the blood-brain barrier (BBB), where it ensures the transport of hydrophobic acids from the blood to the brain. Due to its unique substrate specificity and high expression at the BBB, <span class="hlt">LAT</span>1 is an intriguing target for carrier-mediated transport of drugs into the brain. In this study, a comparative molecular field analysis (CoMFA) model with considerable statistical quality (Q(2) =0.53, R(2) =0.75, Q(2) SE=0.77, R(2) SE=0.57) and good external predictivity (CCC=0.91) was generated. The model was used to guide the synthesis of eight new prodrugs whose affinity for <span class="hlt">LAT</span>1 was tested by using an in situ rat brain perfusion technique. This resulted in the creation of a novel <span class="hlt">LAT</span>1 prodrug with L-tryptophan as the promoiety; it also provided a better understanding of the molecular features of <span class="hlt">LAT</span>1-targeted high-affinity prodrugs, as well as their promoiety and parent drug. The results obtained will be beneficial in the rational design of novel <span class="hlt">LAT</span>1-binding prodrugs and other compounds that bind to <span class="hlt">LAT</span>1. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29486121','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29486121"><span>Reaction <span class="hlt">Electronic</span> <span class="hlt">Flux</span> Perspective on the Mechanism of the Zimmerman Di-π-methane Rearrangement.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Matute, Ricardo A; Pérez, Patricia; Chamorro, Eduardo; Villegas-Escobar, Nery; Cortés-Arriagada, Diego; Herrera, Barbara; Gutiérrez-Oliva, Soledad; Toro-Labbé, Alejandro</p> <p>2018-06-01</p> <p>The reaction <span class="hlt">electronic</span> <span class="hlt">flux</span> (REF) offers a powerful tool in the analysis of reaction mechanisms. Noteworthy, the relationship between aromaticity and REF can eventually reveal subtle <span class="hlt">electronic</span> events associated with reactivity in aromatic systems. In this work, this relationship was studied for the triplet Zimmerman di-π-methane rearrangement. The aromaticity loss and gain taking place during the reaction is well acquainted by the REF, thus shedding light on the <span class="hlt">electronic</span> nature of reactions involving dibenzobarrelenes.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1213722-structural-basis-mob1-dependent-activation-core-mstlats-kinase-cascade-hippo-signaling','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1213722-structural-basis-mob1-dependent-activation-core-mstlats-kinase-cascade-hippo-signaling"><span>Structural basis for Mob1-dependent activation of the core Mst–<span class="hlt">Lats</span> kinase cascade in Hippo signaling</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Ni, Lisheng; Zheng, Yonggang; Hara, Mayuko; ...</p> <p>2015-06-24</p> <p>The Mst–<span class="hlt">Lats</span> kinase cascade is central to the Hippo tumor-suppressive pathway that controls organ size and tissue homeostasis. The adaptor protein Mob1 promotes <span class="hlt">Lats</span> activation by Mst, but the mechanism remains unknown. Here, we show that human Mob1 binds to autophosphorylated docking motifs in active Mst2. This binding enables Mob1 phosphorylation by Mst2. Phosphorylated Mob1 undergoes conformational activation and binds to <span class="hlt">Lats</span>1. We determine the crystal structures of phospho-Mst2–Mob1 and phospho-Mob1–<span class="hlt">Lats</span>1 complexes, revealing the structural basis of both phosphorylation-dependent binding events. Further biochemical and functional analyses demonstrate that Mob1 mediates <span class="hlt">Lats</span>1 activation through dynamic scaffolding and allosteric mechanisms. Thus, Mob1more » acts as a phosphorylation-regulated coupler of kinase activation by virtue of its ability to engage multiple ligands. We propose that stepwise, phosphorylation-triggered docking interactions of nonkinase elements enhance the specificity and robustness of kinase signaling cascades.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20120001578&hterms=Parkinsons&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3DParkinsons','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20120001578&hterms=Parkinsons&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3DParkinsons"><span>The X-Ray Counterpart to <span class="hlt">LAT</span> PSR J2021+4026 and Its Interesting Spectrum</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Weisskopf, Martin C.; Becker, W.; Carraminana, A.; De Luca, A.; Dormandy, M.; Harding, A.; Kanbach, G.; O'Dell, S. L.; Parkinson, P. Saz; Ray, P.; <a style="text-decoration: none; " href="javascript:void(0); " onClick="displayelement('author_20120001578'); toggleEditAbsImage('author_20120001578_show'); toggleEditAbsImage('author_20120001578_hide'); "> <img style="display:inline; width:12px; height:12px; " src="images/arrow-up.gif" width="12" height="12" border="0" alt="hide" id="author_20120001578_show"> <img style="width:12px; height:12px; display:none; " src="images/arrow-down.gif" width="12" height="12" border="0" alt="hide" id="author_20120001578_hide"></p> <p>2011-01-01</p> <p>We report on the likely identification of the X-ray counterpart to <span class="hlt">LAT</span> PSR J2021+4026, using the Chandra X-Ray Observatory ACIS-S3 and timing analysis of Large Area telescope (<span class="hlt">LAT</span>) data from the Fermi satellite. The X-ray source that lies closest (10 arcsec) to the position determined from the Fermi-<span class="hlt">LAT</span> timing solution has no cataloged infrared-to-visible counterpart and we have set an upper limit to its optical I and R band emission. The source exhibits a X-ray spectrum which is different when compared to Geminga and CTA 1, and this may have implications for the evolutionary track of radio-quiet gamma-ray pulsars.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/AD1013850','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/AD1013850"><span>Influence of Herpes Simplex Virus Latency-Associated Transcript (<span class="hlt">LAT</span>) on the Distribution of Latently Infected Neurons</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2007-03-20</p> <p>part of my life, who knows more about herpesviruses than any 8-year-old should, for making me tea and snacks when I was studying or writing, for...of latency (2, 13, 36, 45, 76, 77, 81). However, HSV-2 <span class="hlt">LAT</span> has not been shown to inhibit apoptosis of neuronal cells. HSV has several anti ...apoptotic genes, including ICP27, ICP22, US3, US5, ICP4, and HSV-1 <span class="hlt">LAT</span> (4). Only <span class="hlt">LAT</span> is expressed during latency, suggesting that its anti -apoptotic</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015JGRA..12010175F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015JGRA..12010175F"><span>Counterstreaming <span class="hlt">electrons</span> in small interplanetary magnetic <span class="hlt">flux</span> ropes</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Feng, H. Q.; Zhao, G. Q.; Wang, J. M.</p> <p>2015-12-01</p> <p>Small interplanetary magnetic <span class="hlt">flux</span> ropes (SIMFRs) are commonly observed by spacecraft at 1 AU, and their origin still remains disputed. We investigated the counterstreaming suprathermal <span class="hlt">electron</span> (CSE) signatures of 106 SIMFRs measured by Wind during 1995-2005. We found that 79 (75%) of the 106 <span class="hlt">flux</span> ropes contain CSEs, and the percentages of counterstreaming vary from 8% to 98%, with a mean value of 51%. CSEs are often observed in magnetic clouds (MCs), and this indicates these MCs are still attached to the Sun at both ends. CSEs are also related to heliospheric current sheets (HCSs) and the Earth's bow shock. We divided the SIMFRs into two categories: The first category is far from HCSs, and the second category is in the vicinity of HCSs. The first category has 57 SIMFRs, and only 7 of 57 ropes have no CSEs. This ratio is similar to that of MCs. The second category has 49 SIMFRs; however, 20 of the 49 events have no CSEs. This ratio is larger than that of MCs. These two categories have different origins. One category originates from the solar corona, and most ropes are still connected to the Sun at both ends. The other category is formed near HCSs in the interplanetary space.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29902238','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29902238"><span><span class="hlt">Lat</span>Y136F knock-in mouse model for human IgG4-related disease.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Yamada, Kazunori; Zuka, Masahiko; Ito, Kiyoaki; Mizuguchi, Keishi; Kakuchi, Yasushi; Onoe, Tamehito; Suzuki, Yasunori; Yamagishi, Masakazu; Izui, Shozo; Malissen, Marie; Malissen, Bernard; Kawano, Mitsuhiro</p> <p>2018-01-01</p> <p>The adaptor protein Linker for activation of T cell (<span class="hlt">LAT</span>) is a key signaling hub used by the T cell antigen receptor. Mutant mice expressing loss-of-function mutations affecting <span class="hlt">LAT</span> and including a mutation in which tyrosine 136 is replaced by a phenylalanine (<span class="hlt">Lat</span>Y136F) develop lymphoproliferative disorder involving T helper type 2 effector cells capable of triggering a massive polyclonal B cell activation that leads to hypergammaglobulinemia G1 and E and to non-resolving inflammation and autoimmunity. The purpose of this study was to evaluate whether the phenotypes of <span class="hlt">Lat</span>Y136F knock-in mice resemble the immunohistopathological features of immunoglobulin G4-related disease (IgG4-RD). <span class="hlt">Lat</span>Y136F knock-in mice were sacrificed at 4-20 weeks of age, and pancreas, kidney, salivary gland and lung were obtained. All organs were stained with hematoxylin-eosin and with Azan for estimation of collagen in fibrosis, and the severity scores of inflammation and fibrosis were evaluated. Immunostainings were performed to analyze the types of infiltrating cells. In addition, the effects of corticosteroid treatment on the development of tissue lesions and serum levels of IgG1 were assessed. Tissue lesions characterized by inflammatory mononuclear cell infiltration and fibrosis were detected in pancreas, kidney, and salivary gland starting from 6 weeks of age. Immunostainings showed pronounced infiltration of plasma cells, CD4-positive T cells, and macrophages. Infiltrating plasma cells predominantly expressed IgG1. The extent of inflammation in pancreas and salivary glands was markedly reduced by corticosteroid treatment. <span class="hlt">Lat</span>Y136F knock-in mice displayed increased production of Th2-type IgG1 (a homologue of human IgG4) and developed multiple organ tissue lesions reminiscent of those seen in patients with IgG4-RD. Moreover, the development of these tissue lesions was highly sensitive to corticosteroid treatment like in IgG4-RD. For these reasons we consider the <span class="hlt">Lat</span>Y136F knock-in mouse</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014ATel.6292....1C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014ATel.6292....1C"><span>Fermi <span class="hlt">LAT</span> detection of a GeV flare from blazar TXS 0943+105</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ciprini, S.</p> <p>2014-07-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar TXS 0943+105, also known as GB6 J0946+1016, MG1 J094636+1017 and 2FGL J0946.5+1015 in the second Fermi <span class="hlt">LAT</span> catalog (2FGL, Nolan et al. ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/7184371-investigations-ionosphere-kosmos-anisotropy-electron-fluxes-kev-high-latitudes','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/7184371-investigations-ionosphere-kosmos-anisotropy-electron-fluxes-kev-high-latitudes"><span>Investigations in the ionosphere on Kosmos 378. V. Anisotropy of <span class="hlt">electron</span> <span class="hlt">fluxes</span> of 0. 5-12 keV at high latitudes</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Khokhlov, M.Z.</p> <p>1975-01-01</p> <p><span class="hlt">Electron</span> <span class="hlt">fluxes</span> directed upward and earthward were compared by means of electrostatic analyzers oriented in opposite directions. The reflection coefficients reached 0.3-0.45 in the loss cone and were frequently less than 1 outside the cone. In some cases the <span class="hlt">fluxes</span> of reflected <span class="hlt">electrons</span> exceeded those of incident <span class="hlt">electrons</span>. The direction of the current carried by such <span class="hlt">electrons</span> was mostly opposite to the adopted direction of the system of field-aligned currents in the magnetosphere, which is determined by <span class="hlt">electrons</span> of much lower energies. 17 references.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFMSM43C2729B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFMSM43C2729B"><span>The Role of the Dynamic Plasmapause on Outer Radiation Belt <span class="hlt">Electron</span> <span class="hlt">Flux</span> Enhancement and Three-Belt Structure Formation</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bruff, M.; Jaynes, A. N.; Zhao, H.; Malaspina, D.</p> <p>2017-12-01</p> <p>The plasmasphere is a highly dynamic toroidal region of cold, dense plasma around Earth. Plasma waves exist both inside and outside this region and can contribute to the loss and acceleration of high energy outer radiation belt <span class="hlt">electrons</span>. Early observational studies found an apparent correlation on long time scales between the observed inner edge of the outer radiation belt and the simulated innermost plasmapause location. More recent work using high resolution Van Allen Probe satellite data has found a more complex relationship. The aim of this project was to provide a systematic study of the location and dynamics of the plasmapause compared to the MeV <span class="hlt">electrons</span> in the outer radiation belt. We used spin-averaged <span class="hlt">electron</span> <span class="hlt">flux</span> data from the Relativistic <span class="hlt">Electron</span> Proton Telescope (REPT) and density data derived from the EFW instrument on the Van Allen Probe satellites. We analyzed these data to determine the standoff distance of the location of peak <span class="hlt">electron</span> <span class="hlt">flux</span> of the outer belt MeV <span class="hlt">electrons</span> from the plasmapause. We found that the location of peak <span class="hlt">flux</span> was consistently outside but within ΔL=2.5 from the innermost location of the plasmapause at enhancement times, with an average standoff distance ΔL=1.0 +/- 0.5. This is consistent with the current model of chorus enhancement and previous observations of chorus activity. Finally, we identified "three-belt" structure events where a second outer belt formed and found a repeated pattern of plasmapause dynamics associated with specific changes in <span class="hlt">electron</span> <span class="hlt">flux</span> required to generate and sustain these structures. This study is significant to improving our understanding of how the plasmasphere under differing conditions can both shield Earth from or worsen the impacts of geomagnetic activity.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011JApA...32..169B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011JApA...32..169B"><span>Fermi-<span class="hlt">LAT</span> View of Bright Flaring Gamma-Ray Blazars</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bastieri, D.; Ciprini, S.; Gasparrini, D.</p> <p>2011-06-01</p> <p>The Fermi <span class="hlt">LAT</span> provides a continuous and uniform monitoring of the Universe in the gamma-ray band. During the first year many gamma-ray blazar flares, some unidentified transients and emission by the Sun while in a quiet state were promptly detected. This is mainly due to the design of the mission, featuring a detector, the <span class="hlt">LAT</span> with a wide field of view, and to the operation of the spacecraft itself, that can cover every region of the sky every 3 hours. Nevertheless, the scientific exploitation of this monitoring is more fruitful when early information about transients reaches a broader community. In this respect, the indefatigable activity of flare advocates, who worked on weekly shifts to validate the results and quickly broadcast information about flares and new detections, was the key to most scientific results.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1355738','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1355738"><span>A Search for Transitions between States in Redbacks and Black Widows Using Seven Years of Fermi-<span class="hlt">LAT</span> Observations</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Torres, Diego F.; Ji, Long; Li, Jian</p> <p></p> <p>Considering about seven years of Fermi-Large Area Telescope (<span class="hlt">LAT</span>) data, we present a systematic search for variability that is possibly related to transitions between states in redbacks and black widow systems. In addition, the transitions are characterized by sudden and significant changes in the gamma-ray <span class="hlt">flux</span> that persist on a timescale that is much larger than the orbital period. This phenomenology was already detected in the case of two redback systems, PSR J1023+0038 and PSR J1227-4853, which we present here. We show the existence of only one transition for each of these systems over the past seven years. We determinemore » their spectra, establishing high-energy cutoffs at a few GeV for the high gamma-ray state of PSR J1023+0038, and for both states of PSR J1227-4853. The surveying capability of the Fermi-<span class="hlt">LAT</span> allows further study of whether similar phenomenology has occurred in other sources. Although we have not found any evidence of a state transition for most of the studied pulsars, we note two black-widow systems, PSR J2234+0944 and PSR J1446-4701, whose apparent variabilities are reminiscent of the transitions in PSR J1023+0038 and PSR J1227-4853. Finally, for the other systems, we set limits on potential transitions in their measured gamma-ray light curves.« less</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li class="active"><span>12</span></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_12 --> <div id="page_13" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li class="active"><span>13</span></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="241"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22663847-search-transitions-between-states-redbacks-black-widows-using-seven-years-fermi-lat-observations','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22663847-search-transitions-between-states-redbacks-black-widows-using-seven-years-fermi-lat-observations"><span>A Search for Transitions between States in Redbacks and Black Widows Using Seven Years of Fermi -<span class="hlt">LAT</span> Observations</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Torres, Diego F.; Li, Jian; Rea, Nanda</p> <p></p> <p>Considering about seven years of Fermi -Large Area Telescope (<span class="hlt">LAT</span>) data, we present a systematic search for variability that is possibly related to transitions between states in redbacks and black widow systems. The transitions are characterized by sudden and significant changes in the gamma-ray <span class="hlt">flux</span> that persist on a timescale that is much larger than the orbital period. This phenomenology was already detected in the case of two redback systems, PSR J1023+0038 and PSR J1227−4853, which we present here. We show the existence of only one transition for each of these systems over the past seven years. We determine theirmore » spectra, establishing high-energy cutoffs at a few GeV for the high gamma-ray state of PSR J1023+0038, and for both states of PSR J1227−4853. The surveying capability of the Fermi -<span class="hlt">LAT</span> allows further study of whether similar phenomenology has occurred in other sources. Although we have not found any evidence of a state transition for most of the studied pulsars, we note two black-widow systems, PSR J2234+0944 and PSR J1446−4701, whose apparent variabilities are reminiscent of the transitions in PSR J1023+0038 and PSR J1227−4853. For the other systems, we set limits on potential transitions in their measured gamma-ray light curves.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1355738-search-transitions-between-states-redbacks-black-widows-using-seven-years-fermi-lat-observations','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1355738-search-transitions-between-states-redbacks-black-widows-using-seven-years-fermi-lat-observations"><span>A Search for Transitions between States in Redbacks and Black Widows Using Seven Years of Fermi-<span class="hlt">LAT</span> Observations</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Torres, Diego F.; Ji, Long; Li, Jian; ...</p> <p>2017-02-08</p> <p>Considering about seven years of Fermi-Large Area Telescope (<span class="hlt">LAT</span>) data, we present a systematic search for variability that is possibly related to transitions between states in redbacks and black widow systems. In addition, the transitions are characterized by sudden and significant changes in the gamma-ray <span class="hlt">flux</span> that persist on a timescale that is much larger than the orbital period. This phenomenology was already detected in the case of two redback systems, PSR J1023+0038 and PSR J1227-4853, which we present here. We show the existence of only one transition for each of these systems over the past seven years. We determinemore » their spectra, establishing high-energy cutoffs at a few GeV for the high gamma-ray state of PSR J1023+0038, and for both states of PSR J1227-4853. The surveying capability of the Fermi-<span class="hlt">LAT</span> allows further study of whether similar phenomenology has occurred in other sources. Although we have not found any evidence of a state transition for most of the studied pulsars, we note two black-widow systems, PSR J2234+0944 and PSR J1446-4701, whose apparent variabilities are reminiscent of the transitions in PSR J1023+0038 and PSR J1227-4853. Finally, for the other systems, we set limits on potential transitions in their measured gamma-ray light curves.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2748022','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2748022"><span>Latency-Associated Transcript (<span class="hlt">LAT</span>) Exon 1 Controls Herpes Simplex Virus Species-Specific Phenotypes: Reactivation in the Guinea Pig Genital Model and Neuron Subtype-Specific Latent Expression of LAT▿</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Bertke, Andrea S.; Patel, Amita; Imai, Yumi; Apakupakul, Kathleen; Margolis, Todd P.; Krause, Philip R.</p> <p>2009-01-01</p> <p>Herpes simplex virus 1 (HSV-1) and HSV-2 cause similar acute infections but differ in their abilities to reactivate from trigeminal and lumbosacral dorsal root ganglia. During latency, HSV-1 and HSV-2 also preferentially express their latency-associated transcripts (<span class="hlt">LATs</span>) in different sensory neuronal subtypes that are positive for A5 and KH10 markers, respectively. Chimeric virus studies showed that <span class="hlt">LAT</span> region sequences influence both of these viral species-specific phenotypes. To further map the <span class="hlt">LAT</span> region sequences responsible for these phenotypes, we constructed the chimeric virus HSV2-<span class="hlt">LAT</span>-E1, in which exon 1 (from the <span class="hlt">LAT</span> TATA to the intron splice site) was replaced by the corresponding sequence from HSV-1 <span class="hlt">LAT</span>. In intravaginally infected guinea pigs, HSV2-<span class="hlt">LAT</span>-E1 reactivated inefficiently relative to the efficiency of its rescuant and wild-type HSV-2, but it yielded similar levels of viral DNA, <span class="hlt">LAT</span>, and ICP0 during acute and latent infection. HSV2-<span class="hlt">LAT</span>-E1 preferentially expressed the <span class="hlt">LAT</span> in A5+ neurons (as does HSV-1), while the chimeric viruses HSV2-<span class="hlt">LAT</span>-P1 (<span class="hlt">LAT</span> promoter swap) and HSV2-<span class="hlt">LAT-S</span>1 (<span class="hlt">LAT</span> sequence swap downstream of the promoter) exhibited neuron subtype-specific latent <span class="hlt">LAT</span> expression phenotypes more similar to that of HSV-2 than that of HSV-1. Rescuant viruses displayed the wild-type HSV-2 phenotypes of efficient reactivation in the guinea pig genital model and a tendency to express <span class="hlt">LAT</span> in KH10+ neurons. The region that is critical for HSV species-specific differences in latency and reactivation thus lies between the <span class="hlt">LAT</span> TATA and the intron splice site, and minor differences in the 5′ ends of chimeric sequences in HSV2-<span class="hlt">LAT</span>-E1 and HSV2-<span class="hlt">LAT-S</span>1 point to sequences immediately downstream of the <span class="hlt">LAT</span> TATA. PMID:19641003</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1356758-search-dark-matter-satellites-using-fermi-lat','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1356758-search-dark-matter-satellites-using-fermi-lat"><span>Search For Dark Matter Satellites Using Fermi-<span class="hlt">Lat</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Ackermann, M.</p> <p>2012-02-23</p> <p>Numerical simulations based on the ΛCDM model of cosmology predict a large number of as yet unobserved Galactic dark matter satellites. We report the results of a Large Area Telescope (<span class="hlt">LAT</span>) search for these satellites via the γ-ray emission expected from the annihilation of weakly interacting massive particle (WIMP) dark matter. Some dark matter satellites are expected to have hard γ-ray spectra, finite angular extents, and a lack of counterparts at other wavelengths. We sought to identify <span class="hlt">LAT</span> sources with these characteristics, focusing on γ-ray spectra consistent with WIMP annihilation through themore » $$b \\bar{b}$$ channel. We found no viable dark matter satellite candidates using one year of data, and we present a framework for interpreting this result in the context of numerical simulations to constrain the velocity-averaged annihilation cross section for a conventional 100 GeV WIMP annihilating through the $$b \\bar{b}$$ channel.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012ATel.4158....1C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012ATel.4158....1C"><span>Fermi <span class="hlt">LAT</span> detection of renewed GeV gamma-ray activity from the gravitationally lensed blazar PKS 1830-211</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ciprini, Stefano</p> <p>2012-06-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray <span class="hlt">flux</span> from a source positionally consistent with PKS 1830-211 (also known as 2FGL J1833.6-2104, Nolan et al. 2012, ApJS, 199, 31, placed at RA: 18h 33m 39.9s, Dec -21d 03m 40s, J2000, van Ommen et al., 1995, ApJ, 444, 561). PKS 1830-211 (z=2.507, Lovell et al. 1998, ApJ, 508, L51) is a distant and peculiar flat spectrum radio quasar with intervening absorption systems and being subject to gravitational lensing by a galaxy placed at z=0.886 (Wiklind & Combes 1996, Nature, 379, 11).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017ATel10925....1J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017ATel10925....1J"><span>Fermi <span class="hlt">LAT</span> Detection of a GeV Gamma-Ray Flare from the Be-Pulsar Binary System PSR B1259-63 with Rapid Variability</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Johnson, T. J.; Wood, K. S.; Ray, P. S.; Ferrara, E. C.; Kerr, M. T.; Cheung, C. C.</p> <p>2017-11-01</p> <p>Using data from the Large Area Telescope (<span class="hlt">LAT</span>), one of the two instruments on board the Fermi Gamma-ray Space Telescope, we have detected a > 100 MeV flare from PSR B1259-63 over the time interval 2017-11-02 01:47:25 UTC to 2017-11-03 06:29:13 UTC with a significance of approximately 10 sigma, a preliminary photon <span class="hlt">flux</span> (from 100 MeV to 300 GeV) of (3.1 +/- 0.4) x 10^-6 ph/cm^2/s, and a power-law photon index of 2.6 +/- 0.1, quoted uncertainties are statistical only.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1986Geo....14..111M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1986Geo....14..111M"><span>East Pacific Rise at <span class="hlt">lat</span> 19°S: Evidence for a recent ridge jump</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Morton, Janet L.; Ballard, Robert D.</p> <p>1986-02-01</p> <p>A detailed ANGUS (Acoustically Navigated Geological Undersea Surveyor) photographic and bathymetric survey of the East Pacific Rise (EPR) near <span class="hlt">lat</span> 19°S reveals a small jump of the ridge axis to the west. The axial block in this region consists of two parallel ridges 3 km apart and separated by a 200-m-deep valley. South of <span class="hlt">lat</span> 19°06‧S the plate boundary is a single, narrow (<1 km) ridge. The eastern ridge near <span class="hlt">lat</span> 19°S is shallower than the western ridge and is morphologically a continuation of the narrow, active ridge axis to the south. ANGUS photographs along both ridges and in the intervening valley, however, show that the western ridge is the currently active plate boundary. We suggest that spreading shifted westward from the eastern ridge to its present position within the past 40 000 yr. The EPR in the general region has been characterized by asymmetric spreading for the past 2.4 m.y. The sense of the ridge jump near <span class="hlt">lat</span> 19°S is consistent with the asymmetric spreading, which could have been produced by a series of such jumps.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19760043543&hterms=frequency+modulation&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dfrequency%2Bmodulation','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19760043543&hterms=frequency+modulation&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dfrequency%2Bmodulation"><span>Modulation of auroral <span class="hlt">electron</span> <span class="hlt">fluxes</span> in the frequency range 50 kHz to 10 MHz</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Spiger, R. J.; Murphree, J. S.; Anderson, H. R.; Loewenstein, R. F.</p> <p>1976-01-01</p> <p>A sounding rocket-borne <span class="hlt">electron</span> detector of high time resolution is used to search for modulation of auroral <span class="hlt">electron</span> <span class="hlt">fluxes</span> in the frequency range 50 kHz to 10 MHz and energy range 5-7 keV. Data were telemetered to ground via a 93-kHz subcarrier. A cross-correlation analysis of the data collected indicates low-level modulation near the detection threshold of the instrument. Two U-1 events are observed which are interpreted as indications of modulation. The two modulation events occur during a period of increasing <span class="hlt">flux</span> for a region marking the boundary between two current sheets detected by the payload magnetometer. The strongest argument against interference contamination is the lack of any observable modulation at times other than those mentioned in the study.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4821889','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4821889"><span>Zyxin-Siah2–<span class="hlt">Lats</span>2 axis mediates cooperation between Hippo and TGF-β signalling pathways</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ma, Biao; Cheng, Hongcheng; Gao, Ruize; Mu, Chenglong; Chen, Ling; Wu, Shian; Chen, Quan; Zhu, Yushan</p> <p>2016-01-01</p> <p>The evolutionarily conserved Hippo pathway is a regulator that controls organ size, cell growth and tissue homeostasis. Upstream signals of the Hippo pathway have been widely studied, but how microenvironmental factors coordinately regulate this pathway remains unclear. In this study, we identify LIM domain protein Zyxin, as a scaffold protein, that in response to hypoxia and TGF-β stimuli, forms a ternary complex with <span class="hlt">Lats</span>2 and Siah2 and stabilizes their interaction. This interaction facilitates <span class="hlt">Lats</span>2 ubiquitination and degradation, Yap dephosphorylation and subsequently activation. We show that Zyxin is required for TGF-β and hypoxia-induced <span class="hlt">Lats</span>2 downregulation and deactivation of Hippo signalling in MDA-MB-231 cells. Depletion of Zyxin impairs the capability of cell migration, proliferation and tumourigenesis in a xenograft model. Zyxin is upregulated in human breast cancer and positively correlates with histological stages and metastasis. Our study demonstrates that Zyxin-<span class="hlt">Lats</span>2–Siah2 axis may serve as a potential therapeutic target in cancer treatment. PMID:27030211</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1046941','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1046941"><span>Fermi-<span class="hlt">LAT</span> Discovery of Extended Gamma-Ray Emission in the Direction of Supernova Remnant W51C</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Abdo, A.A.; /Naval Research Lab, Wash., D.C. /Federal City Coll.; Ackermann, M.</p> <p></p> <p>The discovery of bright gamma-ray emission coincident with supernova remnant (SNR) W51C is reported using the Large Area Telescope (<span class="hlt">LAT</span>) onboard the Fermi Gamma-ray Space Telescope. W51C is a middle-aged remnant ({approx}10{sup 4} yr) with intense radio synchrotron emission in its shell and known to be interacting with a molecular cloud. The gamma-ray emission is spatially extended, broadly consistent with the radio and X-ray extent of SNR W51C. The energy spectrum in the 0.2-50 GeV band exhibits steepening toward high energies. The luminosity is greater than 1 x 10{sup 36} erg s{sup -1} given the distance constraint of D >more » 5.5 kpc, which makes this object one of the most luminous gamma-ray sources in our Galaxy. The observed gamma-rays can be explained reasonably by a combination of efficient acceleration of nuclear cosmic rays at supernova shocks and shock-cloud interactions. The decay of neutral p mesons produced in hadronic collisions provides a plausible explanation for the gamma-ray emission. The product of the average gas density and the total energy content of the accelerated protons amounts to {bar n}{sub H} W{sub p} {approx_equal} 5 x 10{sup 51} (D/6 kpc){sup 2} erg cm{sup -3}. <span class="hlt">Electron</span> density constraints from the radio and X-ray bands render it difficult to explain the <span class="hlt">LAT</span> signal as due to inverse Compton scattering. The Fermi <span class="hlt">LAT</span> source coincident with SNR W51C sheds new light on the origin of Galactic cosmic rays.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1357434-fermi-lat-discovery-extended-gamma-ray-emission-direction-supernova-remnant-w51c','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1357434-fermi-lat-discovery-extended-gamma-ray-emission-direction-supernova-remnant-w51c"><span>FERMI <span class="hlt">LAT</span> Discovery of Extended Gamma-Ray Emission in the Direction of Supernova Remnant W51C</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Abdo, A. A.; Ackermann, M.; Ajello, M.; ...</p> <p>2009-10-27</p> <p>In this paper, the discovery of bright gamma-ray emission coincident with supernova remnant (SNR) W51C is reported using the Large Area Telescope (<span class="hlt">LAT</span>) onboard the Fermi Gamma-ray Space Telescope. W51C is a middle-aged remnant (~10 4 yr) with intense radio synchrotron emission in its shell and known to be interacting with a molecular cloud. The gamma-ray emission is spatially extended, broadly consistent with the radio and X-ray extent of SNR W51C. The energy spectrum in the 0.2-50 GeV band exhibits steepening toward high energies. The luminosity is greater than 1 × 10 36 erg s –1 given the distance constraint of D > 5.5 kpc, which makes this object one of the most luminous gamma-ray sources in our Galaxy. The observed gamma-rays can be explained reasonably by a combination of efficient acceleration of nuclear cosmic rays at supernova shocks and shock-cloud interactions. The decay of neutral π mesons produced in hadronic collisions provides a plausible explanation for the gamma-ray emission. The product of the average gas density and the total energy content of the accelerated protons amounts tomore » $$\\bar{n}_{\\rm H}W_p \\simeq 5\\times 10^{51}\\ (D/6\\ {\\rm kpc})^2\\ \\rm erg\\ cm^{-3}$$. <span class="hlt">Electron</span> density constraints from the radio and X-ray bands render it difficult to explain the <span class="hlt">LAT</span> signal as due to inverse Compton scattering. Finally, the Fermi <span class="hlt">LAT</span> source coincident with SNR W51C sheds new light on the origin of Galactic cosmic rays.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20100019267&hterms=Vasileiou&qs=N%3D0%26Ntk%3DAuthor-Name%26Ntx%3Dmode%2Bmatchall%26Ntt%3DVasileiou','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20100019267&hterms=Vasileiou&qs=N%3D0%26Ntk%3DAuthor-Name%26Ntx%3Dmode%2Bmatchall%26Ntt%3DVasileiou"><span>Afterglow Population Studies from Swift Follow-Up Observations of Fermi <span class="hlt">LAT</span> GRBs</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Racusin, Judith L.; Oates, S. R.; McEnery, J.; Vasileiou, V.; Troja, E.; Gehrels, N.</p> <p>2010-01-01</p> <p>The small population of Fermi <span class="hlt">LAT</span> detected GRBs discovered over the last year has been providing interesting and unexpected clues into GRB prompt and afterglow emission mechanisms. Over the last 5 years, it has been Swift that has provided the robust data set of UV/optical and X-ray afterglow observations that opened many windows into other components of GRB emission structure. We explore the new ability to utilize both of these observatories to study the same GRBs over 10 orders of magnitude in energy, although not always concurrently. Almost all <span class="hlt">LAT</span> GRBs that have been followed-up by Swift within 1-day have been clearly detected and carefully observed. We will present the context of the lower-energy afterglows of this special subset of GRBs that has > 100 MeV emission compared to the hundreds in the Swift database that may or may not have been observed by <span class="hlt">LAT</span>, and theorize upon the relationship between these properties and the origin of the high energy gamma-ray emission.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4192586','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4192586"><span>Detergent-Induced Stabilization and Improved 3D Map of the Human Heteromeric Amino Acid Transporter 4F2hc-<span class="hlt">LAT</span>2</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Harder, Daniel; Stauffer, Mirko; Jeckelmann, Jean-Marc; Brühlmann, Béla; Rosell, Albert; Ilgü, Hüseyin; Kovar, Karin; Palacín, Manuel; Fotiadis, Dimitrios</p> <p>2014-01-01</p> <p>Human heteromeric amino acid transporters (HATs) are membrane protein complexes that facilitate the transport of specific amino acids across cell membranes. Loss of function or overexpression of these transporters is implicated in several human diseases such as renal aminoacidurias and cancer. HATs are composed of two subunits, a heavy and a light subunit, that are covalently connected by a disulphide bridge. Light subunits catalyse amino acid transport and consist of twelve transmembrane α-helix domains. Heavy subunits are type II membrane N-glycoproteins with a large extracellular domain and are involved in the trafficking of the complex to the plasma membrane. Structural information on HATs is scarce because of the difficulty in heterologous overexpression. Recently, we had a major breakthrough with the overexpression of a recombinant HAT, 4F2hc-<span class="hlt">LAT</span>2, in the methylotrophic yeast Pichia pastoris. Microgram amounts of purified protein made possible the reconstruction of the first 3D map of a human HAT by negative-stain transmission <span class="hlt">electron</span> microscopy. Here we report the important stabilization of purified human 4F2hc-<span class="hlt">LAT</span>2 using a combination of two detergents, i.e., n-dodecyl-β-D-maltopyranoside and lauryl maltose neopentyl glycol, and cholesteryl hemisuccinate. The superior quality and stability of purified 4F2hc-<span class="hlt">LAT</span>2 allowed the measurement of substrate binding by scintillation proximity assay. In addition, an improved 3D map of this HAT could be obtained. The detergent-induced stabilization of the purified human 4F2hc-<span class="hlt">LAT</span>2 complex presented here paves the way towards its crystallization and structure determination at high-resolution, and thus the elucidation of the working mechanism of this important protein complex at the molecular level. PMID:25299125</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25299125','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25299125"><span>Detergent-induced stabilization and improved 3D map of the human heteromeric amino acid transporter 4F2hc-<span class="hlt">LAT</span>2.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Meury, Marcel; Costa, Meritxell; Harder, Daniel; Stauffer, Mirko; Jeckelmann, Jean-Marc; Brühlmann, Béla; Rosell, Albert; Ilgü, Hüseyin; Kovar, Karin; Palacín, Manuel; Fotiadis, Dimitrios</p> <p>2014-01-01</p> <p>Human heteromeric amino acid transporters (HATs) are membrane protein complexes that facilitate the transport of specific amino acids across cell membranes. Loss of function or overexpression of these transporters is implicated in several human diseases such as renal aminoacidurias and cancer. HATs are composed of two subunits, a heavy and a light subunit, that are covalently connected by a disulphide bridge. Light subunits catalyse amino acid transport and consist of twelve transmembrane α-helix domains. Heavy subunits are type II membrane N-glycoproteins with a large extracellular domain and are involved in the trafficking of the complex to the plasma membrane. Structural information on HATs is scarce because of the difficulty in heterologous overexpression. Recently, we had a major breakthrough with the overexpression of a recombinant HAT, 4F2hc-<span class="hlt">LAT</span>2, in the methylotrophic yeast Pichia pastoris. Microgram amounts of purified protein made possible the reconstruction of the first 3D map of a human HAT by negative-stain transmission <span class="hlt">electron</span> microscopy. Here we report the important stabilization of purified human 4F2hc-<span class="hlt">LAT</span>2 using a combination of two detergents, i.e., n-dodecyl-β-D-maltopyranoside and lauryl maltose neopentyl glycol, and cholesteryl hemisuccinate. The superior quality and stability of purified 4F2hc-<span class="hlt">LAT</span>2 allowed the measurement of substrate binding by scintillation proximity assay. In addition, an improved 3D map of this HAT could be obtained. The detergent-induced stabilization of the purified human 4F2hc-<span class="hlt">LAT</span>2 complex presented here paves the way towards its crystallization and structure determination at high-resolution, and thus the elucidation of the working mechanism of this important protein complex at the molecular level.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29487715','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29487715"><span>Biophysical studies and NMR structure of YAP2 WW domain - <span class="hlt">LATS</span>1 PPxY motif complexes reveal the basis of their interaction.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Verma, Apoorva; Jing-Song, Fan; Finch-Edmondson, Megan L; Velazquez-Campoy, Adrian; Balasegaran, Shanker; Sudol, Marius; Sivaraman, Jayaraman</p> <p>2018-01-30</p> <p>YES-associated protein (YAP) is a major effector protein of the Hippo tumor suppressor pathway, and is phosphorylated by the serine/threonine kinase <span class="hlt">LATS</span>. Their binding is mediated by the interaction between WW domains of YAP and PPxY motifs of <span class="hlt">LATS</span>. Their isoforms, YAP2 and <span class="hlt">LATS</span>1 contain two WW domains and two PPxY motifs respectively. Here, we report the study of the interaction of these domains both in vitro and in human cell lines, to better understand the mechanism of their binding. We show that there is a reciprocal binding preference of YAP2-WW1 with <span class="hlt">LATS</span>1-PPxY2, and YAP2-WW2 with <span class="hlt">LATS</span>1-PPxY1. We solved the NMR structures of these complexes and identified several conserved residues that play a critical role in binding. We further created a YAP2 mutant by swapping the WW domains, and found that YAP2 phosphorylation at S127 by <span class="hlt">LATS</span>1 is not affected by the spatial configuration of its WW domains. This is likely because the region between the PPxY motifs of <span class="hlt">LATS</span>1 is unstructured, even upon binding with its partner. Based on our observations, we propose possible models for the interaction between YAP2 and <span class="hlt">LATS</span>1.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5814282','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5814282"><span>Biophysical studies and NMR structure of YAP2 WW domain - <span class="hlt">LATS</span>1 PPxY motif complexes reveal the basis of their interaction</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Verma, Apoorva; Jing-Song, Fan; Finch-Edmondson, Megan L.; Velazquez-Campoy, Adrian; Balasegaran, Shanker; Sudol, Marius; Sivaraman, Jayaraman</p> <p>2018-01-01</p> <p>YES-associated protein (YAP) is a major effector protein of the Hippo tumor suppressor pathway, and is phosphorylated by the serine/threonine kinase <span class="hlt">LATS</span>. Their binding is mediated by the interaction between WW domains of YAP and PPxY motifs of <span class="hlt">LATS</span>. Their isoforms, YAP2 and <span class="hlt">LATS</span>1 contain two WW domains and two PPxY motifs respectively. Here, we report the study of the interaction of these domains both in vitro and in human cell lines, to better understand the mechanism of their binding. We show that there is a reciprocal binding preference of YAP2-WW1 with <span class="hlt">LATS</span>1-PPxY2, and YAP2-WW2 with <span class="hlt">LATS</span>1-PPxY1. We solved the NMR structures of these complexes and identified several conserved residues that play a critical role in binding. We further created a YAP2 mutant by swapping the WW domains, and found that YAP2 phosphorylation at S127 by <span class="hlt">LATS</span>1 is not affected by the spatial configuration of its WW domains. This is likely because the region between the PPxY motifs of <span class="hlt">LATS</span>1 is unstructured, even upon binding with its partner. Based on our observations, we propose possible models for the interaction between YAP2 and <span class="hlt">LATS</span>1. PMID:29487715</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015ApJ...811..154C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015ApJ...811..154C"><span>Spectra of Cosmic Ray <span class="hlt">Electrons</span> and Diffuse Gamma Rays with the Constraints of AMS-02 and HESS Data</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Chen, Ding; Huang, Jing; Jin, Hong-Bo</p> <p>2015-10-01</p> <p>Recently, AMS-02 reported their results of cosmic ray (CR) observations. In addition to the AMS-02 data, we add HESS data to estimate the spectra of CR <span class="hlt">electrons</span> and the diffuse gamma rays above TeV. In the conventional diffusion model, a global analysis is performed on the spectral features of CR <span class="hlt">electrons</span> and the diffuse gamma rays by the GALRPOP package. The results show that the spectrum structure of the primary component of CR <span class="hlt">electrons</span> cannot be fully reproduced by a simple power law and that the relevant break is around 100 GeV. At the 99% confidence level (C.L.) the injection indices above the break decrease from 2.54 to 2.35, but the ones below the break are only in the range of 2.746-2.751. The spectrum of CR <span class="hlt">electrons</span> does not need to add TeV cutoff to also match the features of the HESS data. Based on the difference between the <span class="hlt">fluxes</span> of CR <span class="hlt">electrons</span> and their primary components, the predicted excess of CR positrons is consistent with the interpretation that these positrons originate from a pulsar or dark matter. In the analysis of the Galactic diffuse gamma rays with the indirect constraint of AMS-02 and HESS data, it is found that the <span class="hlt">fluxes</span> of Galactic diffuse gamma rays are consistent with the GeV data of the Fermi-Large Area Telescope (<span class="hlt">LAT</span>) in the high-latitude regions. The results indicate that inverse Compton scattering is the dominant component in the range of hundreds of GeV to tens of TeV, respectively from the high-latitude regions to the low ones, and in all of the regions of the Galaxy the <span class="hlt">flux</span> of diffuse gamma rays is less than that of CR <span class="hlt">electrons</span> at the energy scale of 20 TeV.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22525298-spectra-cosmic-ray-electrons-diffuse-gamma-rays-constraints-ams-hess-data','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22525298-spectra-cosmic-ray-electrons-diffuse-gamma-rays-constraints-ams-hess-data"><span>SPECTRA OF COSMIC RAY <span class="hlt">ELECTRONS</span> AND DIFFUSE GAMMA RAYS WITH THE CONSTRAINTS OF AMS-02 AND HESS DATA</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Chen, Ding; Jin, Hong-Bo; Huang, Jing, E-mail: hbjin@bao.ac.cn</p> <p>2015-10-01</p> <p>Recently, AMS-02 reported their results of cosmic ray (CR) observations. In addition to the AMS-02 data, we add HESS data to estimate the spectra of CR <span class="hlt">electrons</span> and the diffuse gamma rays above TeV. In the conventional diffusion model, a global analysis is performed on the spectral features of CR <span class="hlt">electrons</span> and the diffuse gamma rays by the GALRPOP package. The results show that the spectrum structure of the primary component of CR <span class="hlt">electrons</span> cannot be fully reproduced by a simple power law and that the relevant break is around 100 GeV. At the 99% confidence level (C.L.) the injectionmore » indices above the break decrease from 2.54 to 2.35, but the ones below the break are only in the range of 2.746–2.751. The spectrum of CR <span class="hlt">electrons</span> does not need to add TeV cutoff to also match the features of the HESS data. Based on the difference between the <span class="hlt">fluxes</span> of CR <span class="hlt">electrons</span> and their primary components, the predicted excess of CR positrons is consistent with the interpretation that these positrons originate from a pulsar or dark matter. In the analysis of the Galactic diffuse gamma rays with the indirect constraint of AMS-02 and HESS data, it is found that the <span class="hlt">fluxes</span> of Galactic diffuse gamma rays are consistent with the GeV data of the Fermi-Large Area Telescope (<span class="hlt">LAT</span>) in the high-latitude regions. The results indicate that inverse Compton scattering is the dominant component in the range of hundreds of GeV to tens of TeV, respectively from the high-latitude regions to the low ones, and in all of the regions of the Galaxy the <span class="hlt">flux</span> of diffuse gamma rays is less than that of CR <span class="hlt">electrons</span> at the energy scale of 20 TeV.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1357531-fermi-lat-observations-geminga-pulsar','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1357531-fermi-lat-observations-geminga-pulsar"><span>Fermi -<span class="hlt">Lat</span> Observations Of The Geminga Pulsar</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Abdo, A. A.</p> <p>2010-08-09</p> <p>We report on the Fermi-<span class="hlt">LAT</span> observations of the Geminga pulsar, the second brightest non-variable GeV source in the γ-ray sky and the first example of a radio-quiet γ-ray pulsar. The observations cover one year, from the launch of the Fermi satellite through 2009 June 15. A data sample of over 60,000 photons enabled us to build a timing solution based solely on γ-rays. Timing analysis shows two prominent peaks, separated by Δphgr = 0.497 ± 0.004 in phase, which narrow with increasing energy. Pulsed γ-rays are observed beyond 18 GeV, precluding emission below 2.7 stellar radii because of magnetic absorption.more » The phase-averaged spectrum was fitted with a power law with exponential cutoff of spectral index Γ = (1.30 ± 0.01 ± 0.04), cutoff energy E 0 = (2.46 ± 0.04 ± 0.17) GeV, and an integral photon <span class="hlt">flux</span> above 0.1 GeV of (4.14 ± 0.02 ± 0.32) × 10 –6 cm –2 s –1. The first uncertainties are statistical and the second ones are systematic. The phase-resolved spectroscopy shows a clear evolution of the spectral parameters, with the spectral index reaching a minimum value just before the leading peak and the cutoff energy having maxima around the peaks. The phase-resolved spectroscopy reveals that pulsar emission is present at all rotational phases. The spectral shape, broad pulse profile, and maximum photon energy favor the outer magnetospheric emission scenarios.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20120013877','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20120013877"><span>PSR J2030+364I: Radio Discovery and Gamma-ray Study of a Middle-aged Pulsar in the Now Identified Fermi-<span class="hlt">LAT</span> Source 1FGL J2030.0+3641</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Camilo, F.; Kerr, M.; Ray, P. S.; Ransom, S. M.; Johnston, S.; Romani, R. W.; Parent, D.; Decesar, M. E.; Harding, A. K.; Donato, D.; <a style="text-decoration: none; " href="javascript:void(0); " onClick="displayelement('author_20120013877'); toggleEditAbsImage('author_20120013877_show'); toggleEditAbsImage('author_20120013877_hide'); "> <img style="display:inline; width:12px; height:12px; " src="images/arrow-up.gif" width="12" height="12" border="0" alt="hide" id="author_20120013877_show"> <img style="width:12px; height:12px; display:none; " src="images/arrow-down.gif" width="12" height="12" border="0" alt="hide" id="author_20120013877_hide"></p> <p>2011-01-01</p> <p>In a radio search with the Green Bank Telescope of three unidentified low Galactic latitude Fermi-<span class="hlt">LAT</span> sources, we have discovered the middle-aged pulsar J2030+3641, associated with IFGL J2030.0+3641 (2FGL J2030.0+3640). Following the detection of gamma-ray pulsations using a radio ephemeris, we have obtained a phase-coherent timing solution based on gamma-ray and radio pulse arrival times that spans the entire Fermi mission. With a rotation period of 0.28, spin-down luminosity of 3 x 10(exp 34) erg/s, and characteristic age of 0.5 Myr, PSR J2030+3641 is a middle-aged neutron star with spin parameters similar to those of the exceedingly gamma-ray-bright and radio-undetected Geminga. Its gamma-ray <span class="hlt">flux</span> is 1 % that of Geminga, primarily because of its much larger distance, as suggested by the large integrated column density of free <span class="hlt">electrons</span>, DM = 246 pc/cu cm. We fit the gamma-ray light curve, along with limited radio polarimetric constraints, to four geometrical models of magnetospheric emission, and while none of the fits have high significance some are encouraging and suggest that further refinements of these models may be worthwhile. We argue that not many more non-millisecond radio pulsars may be detected along the Galactic plane that are responsible for <span class="hlt">LAT</span> sources, but that modified methods to search for gamma-ray pulsations should be productive - PSR J2030+364 I would have been found blindly in gamma rays if only > or approx. 0.8 GeV photons had been considered, owing to its relatively flat spectrum and location in a region of high soft background.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li class="active"><span>13</span></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_13 --> <div id="page_14" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li class="active"><span>14</span></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="261"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20120009480','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20120009480"><span>Search for Dark Matter Satellites Using the Fermi-<span class="hlt">Lat</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ackermann, M.; Albert, A.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Blandford, R. D.; Bloom, E. D.; <a style="text-decoration: none; " href="javascript:void(0); " onClick="displayelement('author_20120009480'); toggleEditAbsImage('author_20120009480_show'); toggleEditAbsImage('author_20120009480_hide'); "> <img style="display:inline; width:12px; height:12px; " src="images/arrow-up.gif" width="12" height="12" border="0" alt="hide" id="author_20120009480_show"> <img style="width:12px; height:12px; display:none; " src="images/arrow-down.gif" width="12" height="12" border="0" alt="hide" id="author_20120009480_hide"></p> <p>2012-01-01</p> <p>Numerical simulations based on the ACDM model of cosmology predict a large number of as yet unobserved Galactic dark matter satellites. We report the results of a Large Area Telescope (<span class="hlt">LAT</span>) search for these satellites via the gamma-ray emission expected from the annihilation of weakly interacting massive particle (WIMP) dark matter. Some dark matter satellites are expected to have hard gamma-ray spectra, finite angular extents, and a lack of counterparts at other wavelengths. We sought to identify <span class="hlt">LAT</span> sources with these characteristics, focusing on gamma-ray spectra consistent with WIMP annihilation through the bb(sup raised bar) channel. We found no viable dark matter satellite candidates using one year of data, and we present a framework for interpreting this result in the context of numerical simulations to constrain the velocity-averaged annihilation cross section for a conventional 100 Ge V WIMP annihilating through the bb(sup raised bar) channel.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015PhPro..74..246A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015PhPro..74..246A"><span>Gamma-telescopes Fermi/<span class="hlt">LAT</span> and GAMMA-400 Trigger Systems Event Recognizing Methods Comparison</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Arkhangelskaja, I. V.; Murchenko, A. E.; Chasovikov, E. N.; Arkhangelskiy, A. I.; Kheymits, M. D.</p> <p></p> <p> value because of its calorimeter thickness is only ∼10 X0 and energy of registered particles is defined by shower profile analysis. Less than 3% photons will be wrongly recognized as <span class="hlt">electrons</span> or protons in double-layer ACtop taking into account both temporal and amplitude trigger marker analysis methods during onboard processing in the counting and triggers signals formation system of GAMMA-400. The proton rejection factor will be ∼10-5. The Fermi/<span class="hlt">LAT</span> based on a 4 × 4 array of identical towers each contains a tracker, calorimeter and data acquisition module. Each tracker consists of 18 x-y silicon-strip layers. The calorimeter in each tower made of eight layers in a hodoscopic arrangement for measure the three-dimensional profiles of showers permits corrections for energy leakage and enhances the capability to discriminate hadronic cosmic rays. The each layer consists of 12 CsI(Tl) based bars. The segmented anticoincidence shield covers the array of towers. Unfortunately, several types of biases lead to systematic effects caused high values of relative systematic uncertainties of the exposure, the number of signal events, the induced fractional signal and so on. For example non confirmed announcement of ∼133 GeV line detection and lost sources in different Fermi catalogues (1FGL, 2FGL, 3FGL) - just well seen in 2FGL Cygnus X-3 (J2032.1+4049) does not appear in 3FGL. It allows to conclude sufficient biases in <span class="hlt">LAT</span> characteristics obtained methods and event recognized algorithms. Now Fermi/<span class="hlt">LAT</span> operates during ∼ 7 years but effective caveats methods continuously to be proposed. Respectively, continuation of measurements with use of other telescopes is necessary, and realization of GAMMA-400 will allow improving the results.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015PhRvA..92f2706R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015PhRvA..92f2706R"><span>Modification of the quantum mechanical <span class="hlt">flux</span> formula for <span class="hlt">electron</span>-hydrogen ionization through Bohm's velocity field</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Randazzo, J. M.; Ancarani, L. U.</p> <p>2015-12-01</p> <p>For the single differential cross section (SDCS) for hydrogen ionization by <span class="hlt">electron</span> impact (e -H problem), we propose a correction to the <span class="hlt">flux</span> formula given by R. Peterkop [Theory of Ionization of Atoms by <span class="hlt">Electron</span> Impact (Colorado Associated University Press, Boulder, 1977)]. The modification is based on an alternative way of defining the kinetic energy fraction, using Bohm's definition of velocities instead of the usual asymptotic kinematical, or geometrical, approximation. It turns out that the solution-dependent, modified energy fraction is equally related to the components of the probability <span class="hlt">flux</span>. Compared to what is usually observed, the correction yields a finite and well-behaved SDCS value in the asymmetrical situation where one of the continuum <span class="hlt">electrons</span> carries all the energy while the other has zero energy. We also discuss, within the S -wave model of the e -H ionization process, the continuity of the SDCS derivative at the equal energy sharing point, a property not so clearly observed in published benchmark results obtained with integral and S -matrix formulas with unequal final states.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017SuScT..30d4002Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017SuScT..30d4002Z"><span>A nanocryotron comparator can connect single-<span class="hlt">flux</span>-quantum circuits to conventional <span class="hlt">electronics</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zhao, Qing-Yuan; McCaughan, Adam N.; Dane, Andrew E.; Berggren, Karl K.; Ortlepp, Thomas</p> <p>2017-04-01</p> <p>Integration with conventional <span class="hlt">electronics</span> offers a straightforward and economical approach to upgrading existing superconducting technologies, such as scaling up superconducting detectors into large arrays and combining single <span class="hlt">flux</span> quantum (SFQ) digital circuits with semiconductor logic gates and memories. However, direct output signals from superconducting devices (e.g., Josephson junctions) are usually not compatible with the input requirements of conventional devices (e.g., transistors). Here, we demonstrate the use of a single three-terminal superconducting-nanowire device, called the nanocryotron (nTron), as a digital comparator to combine SFQ circuits with mature semiconductor circuits such as complementary metal oxide semiconductor (CMOS) circuits. Since SFQ circuits can digitize output signals from general superconducting devices and CMOS circuits can interface existing CMOS-compatible <span class="hlt">electronics</span>, our results demonstrate the feasibility of a general architecture that uses an nTron as an interface to realize a ‘super-hybrid’ system consisting of superconducting detectors, superconducting quantum <span class="hlt">electronics</span>, CMOS logic gates and memories, and other conventional <span class="hlt">electronics</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016ApJ...826..142C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016ApJ...826..142C"><span>Fermi-<span class="hlt">LAT</span> Gamma-Ray Detections of Classical Novae V1369 Centauri 2013 and V5668 Sagittarii 2015</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Cheung, C. C.; Jean, P.; Shore, S. N.; Stawarz, Ł.; Corbet, R. H. D.; Knödlseder, J.; Starrfield, S.; Wood, D. L.; Desiante, R.; Longo, F.; Pivato, G.; Wood, K. S.</p> <p>2016-08-01</p> <p>We report the Fermi Large Area Telescope (<span class="hlt">LAT</span>) detections of high-energy (>100 MeV) γ-ray emission from two recent optically bright classical novae, V1369 Centauri 2013 and V5668 Sagittarii 2015. At early times, Fermi target-of-opportunity observations prompted by their optical discoveries provided enhanced <span class="hlt">LAT</span> exposure that enabled the detections of γ-ray onsets beginning ˜2 days after their first optical peaks. Significant γ-ray emission was found extending to 39-55 days after their initial <span class="hlt">LAT</span> detections, with systematically fainter and longer-duration emission compared to previous γ-ray-detected classical novae. These novae were distinguished by multiple bright optical peaks that encompassed the time spans of the observed γ-rays. The γ-ray light curves and spectra of the two novae are presented along with representative hadronic and leptonic models, and comparisons with other novae detected by the <span class="hlt">LAT</span> are discussed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22242097-new-treatment-human-malignant-melanoma-targeting-type-amino-acid-transporter-lat1-pilot-study-canine-model','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22242097-new-treatment-human-malignant-melanoma-targeting-type-amino-acid-transporter-lat1-pilot-study-canine-model"><span>A new treatment for human malignant melanoma targeting L-type amino acid transporter 1 (<span class="hlt">LAT</span>1): A pilot study in a canine model</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Fukumoto, Shinya; Hanazono, Kiwamu; Fu, Dah-Renn</p> <p>2013-09-13</p> <p>Highlights: •<span class="hlt">LAT</span>1 is highly expressed in tumors but at low levels in normal tissues. •We examine <span class="hlt">LAT</span>1 expression and function in malignant melanoma (MM). •<span class="hlt">LAT</span>1 expression in MM tissues and cell lines is higher than those in normal tissues. •<span class="hlt">LAT</span>1 selective inhibitors inhibit amino acid uptake and cell growth in MM cells. •New chemotherapeutic protocols including <span class="hlt">LAT</span>1 inhibitors are effective for treatment. -- Abstract: L-type amino acid transporter 1 (<span class="hlt">LAT</span>1), an isoform of amino acid transport system L, transports branched or aromatic amino acids essential for fundamental cellular activities such as cellular growth, proliferation and maintenance. This amino acid transportermore » recently has received attention because of its preferential and up-regulated expression in a variety of human tumors in contrast to its limited distribution and low-level expression in normal tissues. In this study, we explored the feasibility of using <span class="hlt">LAT</span>1 inhibitor as a new therapeutic agent for human malignant melanomas (MM) using canine spontaneous MM as a model for human MM. A comparative study of <span class="hlt">LAT</span> expression was performed in 48 normal tissues, 25 MM tissues and five cell lines established from MM. The study observed <span class="hlt">LAT</span>1 mRNA levels from MM tissues and cell lines that were significantly (P < 0.01) higher than in normal tissues. Additionally, MM with distant metastasis showed a higher expression than those without distant metastasis. Functional analysis of <span class="hlt">LAT</span>1 was performed on one of the five cell lines, CMeC-1. [{sup 3}H]L-Leucine uptake and cellular growth activities in CMeC-1 were inhibited in a dose-dependent manner by selective <span class="hlt">LAT</span>1 inhibitors (2-amino-2-norbornane-carboxylic acid, BCH and melphalan, LPM). Inhibitory growth activities of various conventional anti-cancer drugs, including carboplatin, cyclophosphamide, dacarbazine, doxorubicin, mitoxantrone, nimustine, vinblastine and vincristine, were significantly (P < 0.05) enhanced by combination use with BCH or</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22320380-cap-trade-schemes-waste-management-case-study-landfill-allowance-trading-scheme-lats-england','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22320380-cap-trade-schemes-waste-management-case-study-landfill-allowance-trading-scheme-lats-england"><span>Cap and trade schemes on waste management: A case study of the Landfill Allowance Trading Scheme (<span class="hlt">LATS</span>) in England</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Calaf-Forn, Maria, E-mail: mcalaf@ent.cat; ENT Environment and Management, Carrer Sant Joan 39, First Floor, E-08800 Vilanova i la Geltrú, Barcelona; Roca, Jordi</p> <p></p> <p>Highlights: • <span class="hlt">LATS</span> has been effective to achieve a reduction of the amount of landfilled waste. • <span class="hlt">LATS</span> has been one of the few environmental instruments for waste management with a cap and trade methodology. • <span class="hlt">LATS</span> has achieved to increase recycling of the biodegradable and other waste fractions. - Abstract: The Landfill Allowance Trading Scheme (<span class="hlt">LATS</span>) is one of the main instruments used in England to enforce the landfill diversion targets established in the Directive 1999/31/EC of the European Parliament and of the Council of 26 April 1999 on the landfill of waste (Landfill Directive). Through the <span class="hlt">LATS</span>, biodegradablemore » municipal waste (BMW) allowances for landfilling are allocated to each local authority, otherwise known as waste disposal authorities (WDAs). The quantity of landfill allowances received is expected to decrease continuously from 2005/06 to 2019/20 so as to meet the objectives of the Landfill Directive. To achieve their commitments, WDAs can exchange, buy, sell or transfer allowances among each other, or may re-profile their own allocation through banking and/or borrowing. Despite the goals for the first seven years – which included two target years (2005/06 and 2009/10) – being widely achieved (the average allocation of allowances per WDA was 22.9% higher than those finally used), market activity among WDAs was high and prices were not very stable. Results in terms of waste reduction and recycling levels have been satisfactory. The reduction of BMW landfilled (in percentage) was higher during the first seven years of the <span class="hlt">LATS</span> period (2005/06–2011/12) (around 7% annually) than during the previous period (2001/02–2004/05) (4.2% annually). Since 2008, the significance of the <span class="hlt">LATS</span> diminished because of an increase in the rate of the UK Landfill Tax. The <span class="hlt">LATS</span> was suppressed after the 2012/13 target year, before what it was initially scheduled. The purpose of this paper is to describe the particularities of the <span class="hlt">LATS</span>, analyse its</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.dtic.mil/docs/citations/AD1014430','DTIC-ST'); return false;" href="http://www.dtic.mil/docs/citations/AD1014430"><span><span class="hlt">Lat</span>Mix 2011 and 2012 Dispersion Analysis</span></a></p> <p><a target="_blank" href="http://www.dtic.mil/">DTIC Science & Technology</a></p> <p></p> <p>2015-09-30</p> <p>work included the airborne lidar operations as well as a substantial part of the field operations and analysis. A primary objective of our <span class="hlt">Lat</span>Mix... lidar ) surveys of evolving dye experiments as a tool for studying submesoscale lateral dispersion. 2 Numerous papers by our group relating to the...drifter / lidar effort, however, there are additional aspects of the data and analysis that are beyond the scope of these already-in-progress</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1212474-background-correction-algorithm-van-allen-probes-mageis-electron-flux-measurements','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1212474-background-correction-algorithm-van-allen-probes-mageis-electron-flux-measurements"><span>A background correction algorithm for Van Allen Probes MagEIS <span class="hlt">electron</span> <span class="hlt">flux</span> measurements</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Claudepierre, S. G.; O'Brien, T. P.; Blake, J. B.; ...</p> <p>2015-07-14</p> <p>We describe an automated computer algorithm designed to remove background contamination from the Van Allen Probes Magnetic <span class="hlt">Electron</span> Ion Spectrometer (MagEIS) <span class="hlt">electron</span> <span class="hlt">flux</span> measurements. We provide a detailed description of the algorithm with illustrative examples from on-orbit data. We find two primary sources of background contamination in the MagEIS <span class="hlt">electron</span> data: inner zone protons and bremsstrahlung X-rays generated by energetic <span class="hlt">electrons</span> interacting with the spacecraft material. Bremsstrahlung X-rays primarily produce contamination in the lower energy MagEIS <span class="hlt">electron</span> channels (~30–500 keV) and in regions of geospace where multi-M eV <span class="hlt">electrons</span> are present. Inner zone protons produce contamination in all MagEIS energymore » channels at roughly L < 2.5. The background-corrected MagEIS <span class="hlt">electron</span> data produce a more accurate measurement of the <span class="hlt">electron</span> radiation belts, as most earlier measurements suffer from unquantifiable and uncorrectable contamination in this harsh region of the near-Earth space environment. These background-corrected data will also be useful for spacecraft engineering purposes, providing ground truth for the near-Earth <span class="hlt">electron</span> environment and informing the next generation of spacecraft design models (e.g., AE9).« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1355708-fermi-lat-gamma-ray-detections-classical-novae-v1369-centauri-v5668-sagittarii','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1355708-fermi-lat-gamma-ray-detections-classical-novae-v1369-centauri-v5668-sagittarii"><span>Fermi-<span class="hlt">LAT</span> gamma ray detections of classical novae V1369 centauri 2013 and V5668 Sagittarii 2015</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Cheung, C. C.; Jean, P.; Shore, S. N.; ...</p> <p>2016-07-27</p> <p>Here, we report the Fermi Large Area Telescope (<span class="hlt">LAT</span>) detections of high-energy (>100 MeV) γ-ray emission from two recent optically bright classical novae, V1369 Centauri 2013 and V5668 Sagittarii 2015. Furthermore, at early times, Fermi target-of-opportunity observations prompted by their optical discoveries provided enhanced <span class="hlt">LAT</span> exposure that enabled the detections of γ-ray onsets beginning ~2 days after their first optical peaks. Significant γ-ray emission was found extending to 39–55 days after their initial <span class="hlt">LAT</span> detections, with systematically fainter and longer-duration emission compared to previous γ-ray-detected classical novae. These novae were distinguished by multiple bright optical peaks that encompassed the timemore » spans of the observed γ-rays. Finally, we discussed the γ-ray light curves and spectra of the two novae are presented along with representative hadronic and leptonic models, and comparisons with other novae detected by the <span class="hlt">LAT</span>.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016ATel.9594....1C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016ATel.9594....1C"><span>Fermi-<span class="hlt">LAT</span> Gamma-ray Observations of Nova Lupus 2016 (ASASSN-16kt)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Cheung, C. C.; Jean, P.; Shore, S. N.; Fermi Large Area Telescope Collaboration</p> <p>2016-10-01</p> <p>The Fermi Gamma-ray Space Telescope performed a ~6-day Target of Opportunity (ToO) observation of Nova Lupus 2016 (ATel #9538, #9539, CBET #4322) that commenced on September 28. Considering earlier all-sky survey Large Area Telescope (<span class="hlt">LAT</span>) observations as well, preliminary analysis indicates gamma-ray emission at ~2 sigma was detected around 1 to 2 days after the optical peak on September 25th (pre-validated AAVSO visual lightcurve; ATel #9550, CBET #4322) when the optical spectra show opaque ejecta, similar to previous gamma-ray detected novae (Fermi-<span class="hlt">LAT</span> collaboration, 2014 Science 345, 554; Cheung et al. 2016 ApJ 826, 142).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005JGRA..110.4201V','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005JGRA..110.4201V"><span>Solar, interplanetary, and magnetospheric parameters for the radiation belt energetic <span class="hlt">electron</span> <span class="hlt">flux</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Vassiliadis, D.; Fung, S. F.; Klimas, A. J.</p> <p>2005-04-01</p> <p>In developing models of the radiation belt energetic <span class="hlt">electron</span> <span class="hlt">flux</span>, it is important to include the states of the interplanetary medium and the magnetosphere, as well as the solar activity. In this study we choose the log <span class="hlt">flux</span> je(t;L;E) at 2-6 MeV, as measured by the Proton-<span class="hlt">Electron</span> Telescope (PET) on SAMPEX in the period 1993-2002, as a representative <span class="hlt">flux</span> variable and evaluate the usefulness of 17 interplanetary and magnetospheric (IP/MS) parameters in its specification. The reference parameter is the solar wind velocity, chosen because of its known high geoeffectiveness. We use finite impulse response filters to represent the effective coupling of the individual parameters to the log <span class="hlt">flux</span>. We measure the temporal and spatial scales of the coupling using the impulse response function and the input's geoeffectiveness using the data-model correlation. The correlation profile as a function of L is complex, and we identify its peaks in reference to the radial regions P0 (L = 3.1-4.0, inner edge of the outer belt), P1 (4.1-7.5, main outer belt), and P2 (>7.5, quasi-trapped population), whose boundaries are determined from a radial correlative analysis (Vassiliadis et al., 2003b). Using the profiles, we classify the IP/MS parameters in four categories: (1) For the solar wind velocity and pressure the correlation is high and largely independent of L across P0 and P1, reaching its maximum in L = 4.8-6.1, or the central part of P1. (2) The IMF BSouth component and related IP/MS parameters have a bimodal correlation function, with peaks in region P0 (L = 3.0-4.1) and the geosynchronous orbit region within P1. (3) The IMF BNorth and four other interplanetary or solar irradiance parameters have a minimum correlation in P1, while the highest correlation is in the slot-outer belt boundary (L = 2.5). (4) Finally, the solar wind density has a unique correlation profile, which is anticorrelated with that of the solar wind velocity for certain L shells. We verify this</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1356589-hess-fermi-lat-discovery-rays-from-blazar','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1356589-hess-fermi-lat-discovery-rays-from-blazar"><span>HESS and Fermi-<span class="hlt">LAT</span> discovery of γ-rays from the blazar 1ES 1312-423</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Abramowski, A.; Acero, F.; Aharonian, F.; ...</p> <p>2013-08-01</p> <p>In this study, a deep observation campaign carried out by the High Energy Stereoscopic System (HESS) on Centaurus A enabled the discovery of γ-rays from the blazar 1ES 1312-423, 2° away from the radio galaxy. With a differential <span class="hlt">flux</span> at 1 TeV of (Φ1 TeV) = (1.9 ± 0.6stat ± 0.4sys) × 10 -13 cm -2 s -1 TeV -1 corresponding to 0.5 percent of the Crab nebula differential <span class="hlt">flux</span> and a spectral index Γ = 2.9 ± 0.5stat ± 0.2sys, 1ES 1312-423 is one of the faintest sources ever detected in the very high energy (E > 100 GeV)more » extragalactic sky. A careful analysis using three and a half years of Fermi Large Area Telescope (Fermi-<span class="hlt">LAT</span>) data allows the discovery at high energies (E > 100 MeV) of a hard spectrum (Γ = 1.4 ± 0.4stat ± 0.2sys) source coincident with 1ES 1312-423. Radio, optical, UV and X-ray observations complete the spectral energy distribution of this blazar, now covering 16 decades in energy. Lastly, the emission is successfully fitted with a synchrotron self-Compton model for the non-thermal component, combined with a blackbody spectrum for the optical emission from the host galaxy.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1356762','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1356762"><span>Psr J2030+3641: Radio Discovery And Gamma-Ray Study Of A Middle-Aged Pulsar In The Now Identified Fermi -<span class="hlt">Lat</span> Source 1FGL J2030.0+3641</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Camilo, F.; Kerr, M.; Ray, P. S.</p> <p>2012-01-23</p> <p>In a radio search with the Green Bank Telescope of three unidentified low Galactic latitude Fermi-<span class="hlt">LAT</span> sources, we have discovered the middle-aged pulsar J2030+3641, associated with 1FGL J2030.0+3641 (2FGL J2030.0+3640). Following the detection of gamma-ray pulsations using a radio ephemeris, we have obtained a phase-coherent timing solution based on gamma-ray and radio pulse arrival times that spans the entire Fermi mission. With a rotation period of 0.2 s, spin-down luminosity of 3X10 34 erg s -1, and characteristic age of 0.5 Myr, PSR J2030+3641 is a middle-aged neutron star with spin parameters similar to those of the exceedingly gamma-ray-bright andmore » radio-undetected Geminga. Its gamma-ray <span class="hlt">flux</span> is 1% that of Geminga, primarily because of its much larger distance, as suggested by the large integrated column density of free <span class="hlt">electrons</span>, DM = 246 pc cm-3. We fit the gamma-ray light curve, along with limited radio polarimetric constraints, to four geometrical models of magnetospheric emission, and while none of the fits have high significance some are encouraging and suggest that further refinements of these models may be worthwhile. We argue that not many more non-millisecond radio pulsars may be detected along the Galactic plane that are responsible for <span class="hlt">LAT</span> sources, but that modified methods to search for gamma-ray pulsations should be productive — PSR J2030+3641 would have been found blindly in gamma rays if only & 0:8 GeV photons had been considered, owing to its relatively flat spectrum and location in a region of high soft background.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/874724','DOE-PATENT-XML'); return false;" href="https://www.osti.gov/servlets/purl/874724"><span>Fast <span class="hlt">flux</span> locked loop</span></a></p> <p><a target="_blank" href="http://www.osti.gov/doepatents">DOEpatents</a></p> <p>Ganther, Jr., Kenneth R.; Snapp, Lowell D.</p> <p>2002-09-10</p> <p>A <span class="hlt">flux</span> locked loop for providing an electrical feedback signal, the <span class="hlt">flux</span> locked loop employing radio-frequency components and technology to extend the <span class="hlt">flux</span> modulation frequency and tracking loop bandwidth. The <span class="hlt">flux</span> locked loop of the present invention has particularly useful application in read-out <span class="hlt">electronics</span> for DC SQUID magnetic measurement systems, in which case the electrical signal output by the <span class="hlt">flux</span> locked loop represents an unknown magnetic <span class="hlt">flux</span> applied to the DC SQUID.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1356739-fermi-lat-observations-diffuse-ray-emission-implications-cosmic-rays-interstellar-medium','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1356739-fermi-lat-observations-diffuse-ray-emission-implications-cosmic-rays-interstellar-medium"><span>Fermi-<span class="hlt">LAT</span> observations of the diffuse γ-ray emission: Implications for cosmic rays and the interstellar medium</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Ackermann, M.; Ajello, M.; Atwood, W. B.; ...</p> <p>2012-04-09</p> <p>The γ-ray sky >100 MeV is dominated by the diffuse emissions from interactions of cosmic rays with the interstellar gas and radiation fields of the Milky Way. Our observations of these diffuse emissions provide a tool to study cosmic-ray origin and propagation, and the interstellar medium. We present measurements from the first 21 months of the Fermi Large Area Telescope (Fermi-<span class="hlt">LAT</span>) mission and compare with models of the diffuse γ-ray emission generated using the GALPROP code. The models are fitted to cosmic-ray data and incorporate astrophysical input for the distribution of cosmic-ray sources, interstellar gas, and radiation fields. In ordermore » to assess uncertainties associated with the astrophysical input, a grid of models is created by varying within observational limits the distribution of cosmic-ray sources, the size of the cosmic-ray confinement volume (halo), and the distribution of interstellar gas. An all-sky maximum-likelihood fit is used to determine the X CO factor, the ratio between integrated CO-line intensity and H2 column density, the <span class="hlt">fluxes</span> and spectra of the γ-ray point sources from the first Fermi-<span class="hlt">LAT</span> catalog, and the intensity and spectrum of the isotropic background including residual cosmic rays that were misclassified as γ-rays, all of which have some dependency on the assumed diffuse emission model. The models are compared on the basis of their maximum-likelihood ratios as well as spectra, longitude, and latitude profiles. Here, we provide residual maps for the data following subtraction of the diffuse emission models. The models are consistent with the data at high and intermediate latitudes but underpredict the data in the inner Galaxy for energies above a few GeV. Possible explanations for this discrepancy are discussed, including the contribution by undetected point-source populations and spectral variations of cosmic rays throughout the Galaxy. In the outer Galaxy, we find that the data prefer models with a flatter</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22034580-fermi-lat-observations-diffuse-gamma-ray-emission-implications-cosmic-rays-interstellar-medium','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22034580-fermi-lat-observations-diffuse-gamma-ray-emission-implications-cosmic-rays-interstellar-medium"><span>FERMI-<span class="hlt">LAT</span> OBSERVATIONS OF THE DIFFUSE {gamma}-RAY EMISSION: IMPLICATIONS FOR COSMIC RAYS AND THE INTERSTELLAR MEDIUM</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Ackermann, M.; Ajello, M.; Bechtol, K.</p> <p></p> <p>The {gamma}-ray sky >100 MeV is dominated by the diffuse emissions from interactions of cosmic rays with the interstellar gas and radiation fields of the Milky Way. Observations of these diffuse emissions provide a tool to study cosmic-ray origin and propagation, and the interstellar medium. We present measurements from the first 21 months of the Fermi Large Area Telescope (Fermi-<span class="hlt">LAT</span>) mission and compare with models of the diffuse {gamma}-ray emission generated using the GALPROP code. The models are fitted to cosmic-ray data and incorporate astrophysical input for the distribution of cosmic-ray sources, interstellar gas, and radiation fields. To assess uncertaintiesmore » associated with the astrophysical input, a grid of models is created by varying within observational limits the distribution of cosmic-ray sources, the size of the cosmic-ray confinement volume (halo), and the distribution of interstellar gas. An all-sky maximum-likelihood fit is used to determine the X{sub CO} factor, the ratio between integrated CO-line intensity and H{sub 2} column density, the <span class="hlt">fluxes</span> and spectra of the {gamma}-ray point sources from the first Fermi-<span class="hlt">LAT</span> catalog, and the intensity and spectrum of the isotropic background including residual cosmic rays that were misclassified as {gamma}-rays, all of which have some dependency on the assumed diffuse emission model. The models are compared on the basis of their maximum-likelihood ratios as well as spectra, longitude, and latitude profiles. We also provide residual maps for the data following subtraction of the diffuse emission models. The models are consistent with the data at high and intermediate latitudes but underpredict the data in the inner Galaxy for energies above a few GeV. Possible explanations for this discrepancy are discussed, including the contribution by undetected point-source populations and spectral variations of cosmic rays throughout the Galaxy. In the outer Galaxy, we find that the data prefer models with a</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1356739','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1356739"><span>Fermi-<span class="hlt">LAT</span> observations of the diffuse γ-ray emission: Implications for cosmic rays and the interstellar medium</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Ackermann, M.; Ajello, M.; Atwood, W. B.</p> <p></p> <p>The γ-ray sky >100 MeV is dominated by the diffuse emissions from interactions of cosmic rays with the interstellar gas and radiation fields of the Milky Way. Our observations of these diffuse emissions provide a tool to study cosmic-ray origin and propagation, and the interstellar medium. We present measurements from the first 21 months of the Fermi Large Area Telescope (Fermi-<span class="hlt">LAT</span>) mission and compare with models of the diffuse γ-ray emission generated using the GALPROP code. The models are fitted to cosmic-ray data and incorporate astrophysical input for the distribution of cosmic-ray sources, interstellar gas, and radiation fields. In ordermore » to assess uncertainties associated with the astrophysical input, a grid of models is created by varying within observational limits the distribution of cosmic-ray sources, the size of the cosmic-ray confinement volume (halo), and the distribution of interstellar gas. An all-sky maximum-likelihood fit is used to determine the X CO factor, the ratio between integrated CO-line intensity and H2 column density, the <span class="hlt">fluxes</span> and spectra of the γ-ray point sources from the first Fermi-<span class="hlt">LAT</span> catalog, and the intensity and spectrum of the isotropic background including residual cosmic rays that were misclassified as γ-rays, all of which have some dependency on the assumed diffuse emission model. The models are compared on the basis of their maximum-likelihood ratios as well as spectra, longitude, and latitude profiles. Here, we provide residual maps for the data following subtraction of the diffuse emission models. The models are consistent with the data at high and intermediate latitudes but underpredict the data in the inner Galaxy for energies above a few GeV. Possible explanations for this discrepancy are discussed, including the contribution by undetected point-source populations and spectral variations of cosmic rays throughout the Galaxy. In the outer Galaxy, we find that the data prefer models with a flatter</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012ApJ...750....3A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012ApJ...750....3A"><span>Fermi-<span class="hlt">LAT</span> Observations of the Diffuse γ-Ray Emission: Implications for Cosmic Rays and the Interstellar Medium</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ackermann, M.; Ajello, M.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Berenji, B.; Blandford, R. D.; Bloom, E. D.; Bonamente, E.; Borgland, A. W.; Brandt, T. J.; Bregeon, J.; Brigida, M.; Bruel, P.; Buehler, R.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caraveo, P. A.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Chekhtman, A.; Chiang, J.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Conrad, J.; Cutini, S.; de Angelis, A.; de Palma, F.; Dermer, C. D.; Digel, S. W.; Silva, E. do Couto e.; Drell, P. S.; Drlica-Wagner, A.; Falletti, L.; Favuzzi, C.; Fegan, S. J.; Ferrara, E. C.; Focke, W. B.; Fortin, P.; Fukazawa, Y.; Funk, S.; Fusco, P.; Gaggero, D.; Gargano, F.; Germani, S.; Giglietto, N.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Grove, J. E.; Guiriec, S.; Gustafsson, M.; Hadasch, D.; Hanabata, Y.; Harding, A. K.; Hayashida, M.; Hays, E.; Horan, D.; Hou, X.; Hughes, R. E.; Jóhannesson, G.; Johnson, A. S.; Johnson, R. P.; Kamae, T.; Katagiri, H.; Kataoka, J.; Knödlseder, J.; Kuss, M.; Lande, J.; Latronico, L.; Lee, S.-H.; Lemoine-Goumard, M.; Longo, F.; Loparco, F.; Lott, B.; Lovellette, M. N.; Lubrano, P.; Mazziotta, M. N.; McEnery, J. E.; Michelson, P. F.; Mitthumsiri, W.; Mizuno, T.; Monte, C.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Naumann-Godo, M.; Norris, J. P.; Nuss, E.; Ohsugi, T.; Okumura, A.; Omodei, N.; Orlando, E.; Ormes, J. F.; Paneque, D.; Panetta, J. H.; Parent, D.; Pesce-Rollins, M.; Pierbattista, M.; Piron, F.; Pivato, G.; Porter, T. A.; Rainò, S.; Rando, R.; Razzano, M.; Razzaque, S.; Reimer, A.; Reimer, O.; Sadrozinski, H. F.-W.; Sgrò, C.; Siskind, E. J.; Spandre, G.; Spinelli, P.; Strong, A. W.; Suson, D. J.; Takahashi, H.; Tanaka, T.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Tibaldo, L.; Tinivella, M.; Torres, D. F.; Tosti, G.; Troja, E.; Usher, T. L.; Vandenbroucke, J.; Vasileiou, V.; Vianello, G.; Vitale, V.; Waite, A. P.; Wang, P.; Winer, B. L.; Wood, K. S.; Wood, M.; Yang, Z.; Ziegler, M.; Zimmer, S.</p> <p>2012-05-01</p> <p>The γ-ray sky >100 MeV is dominated by the diffuse emissions from interactions of cosmic rays with the interstellar gas and radiation fields of the Milky Way. Observations of these diffuse emissions provide a tool to study cosmic-ray origin and propagation, and the interstellar medium. We present measurements from the first 21 months of the Fermi Large Area Telescope (Fermi-<span class="hlt">LAT</span>) mission and compare with models of the diffuse γ-ray emission generated using the GALPROP code. The models are fitted to cosmic-ray data and incorporate astrophysical input for the distribution of cosmic-ray sources, interstellar gas, and radiation fields. To assess uncertainties associated with the astrophysical input, a grid of models is created by varying within observational limits the distribution of cosmic-ray sources, the size of the cosmic-ray confinement volume (halo), and the distribution of interstellar gas. An all-sky maximum-likelihood fit is used to determine the X CO factor, the ratio between integrated CO-line intensity and H2 column density, the <span class="hlt">fluxes</span> and spectra of the γ-ray point sources from the first Fermi-<span class="hlt">LAT</span> catalog, and the intensity and spectrum of the isotropic background including residual cosmic rays that were misclassified as γ-rays, all of which have some dependency on the assumed diffuse emission model. The models are compared on the basis of their maximum-likelihood ratios as well as spectra, longitude, and latitude profiles. We also provide residual maps for the data following subtraction of the diffuse emission models. The models are consistent with the data at high and intermediate latitudes but underpredict the data in the inner Galaxy for energies above a few GeV. Possible explanations for this discrepancy are discussed, including the contribution by undetected point-source populations and spectral variations of cosmic rays throughout the Galaxy. In the outer Galaxy, we find that the data prefer models with a flatter distribution of cosmic</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27890657','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27890657"><span>Targeting tumor highly-expressed <span class="hlt">LAT</span>1 transporter with amino acid-modified nanoparticles: Toward a novel active targeting strategy in breast cancer therapy.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Li, Lin; Di, Xingsheng; Wu, Mingrui; Sun, Zhisu; Zhong, Lu; Wang, Yongjun; Fu, Qiang; Kan, Qiming; Sun, Jin; He, Zhonggui</p> <p>2017-04-01</p> <p>Designing active targeting nanocarriers with increased cellular accumulation of chemotherapeutic agents is a promising strategy in cancer therapy. Herein, we report a novel active targeting strategy based on the large amino acid transporter 1 (<span class="hlt">LAT</span>1) overexpressed in a variety of cancers. Glutamate was conjugated to polyoxyethylene stearate as a targeting ligand to achieve <span class="hlt">LAT</span>1-targeting PLGA nanoparticles. The targeting efficiency of nanoparticles was investigated in HeLa and MCF-7 cells. Significant increase in cellular uptake and cytotoxicity was observed in <span class="hlt">LAT</span>1-targeting nanoparticles compared to the unmodified ones. More interestingly, the internalized <span class="hlt">LAT</span>1 together with targeting nanoparticles could recycle back to the cell membrane within 3 h, guaranteeing sufficient transporters on cell membrane for continuous cellular uptake. The <span class="hlt">LAT</span>1 targeting nanoparticles exhibited better tumor accumulation and antitumor effects. These results suggested that the overexpressed <span class="hlt">LAT</span>1 on cancer cells holds a great potential to be a high-efficiency target for the rational design of active-targeting nanosystems. Copyright © 2016 Elsevier Inc. All rights reserved.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li class="active"><span>14</span></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_14 --> <div id="page_15" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li class="active"><span>15</span></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="281"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013ATel.4885....1C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013ATel.4885....1C"><span>Fermi <span class="hlt">LAT</span> detection of a GeV flare from blazar S5 1217+71</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ciprini, Stefano</p> <p>2013-03-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar S5 1217+71, also known as TXS 1217+713 and 2FGL J1219.2+7107 in the second Fermi <span class="hlt">LAT</span> catalog (2FGL, Nolan et al. 2012, ApJS, 199, 31) with VLBI coordinates, (J2000.0), R.A: 185.015118 deg, Dec.: +71.091981 deg (Petrov et al.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1357565-vela-pulsar-results-from-first-year-fermi-lat-observations','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1357565-vela-pulsar-results-from-first-year-fermi-lat-observations"><span>The vela pulsar: results from the first year of FERMI <span class="hlt">lat</span> observations</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Abdo, A. A.; Ackermann, M.; Ajello, M.; ...</p> <p>2010-03-18</p> <p>Here, we report on analysis of timing and spectroscopy of the Vela pulsar using 11 months of observations with the Large Area Telescope (<span class="hlt">LAT</span>) on the Fermi Gamma-ray Space Telescope. The intrinsic brightness of Vela at GeV energies combined with the angular resolution and sensitivity of the <span class="hlt">LAT</span> allows us to make the most detailed study to date of the energy-dependent light curves and phase-resolved spectra, using a <span class="hlt">LAT</span>-derived timing model. The light curve consists of two peaks (P1 and P2) connected by bridge emission containing a third peak (P3). We have confirmed the strong decrease of the P1/P2 ratiomore » with increasing energy seen with EGRET and previous Fermi <span class="hlt">LAT</span> data, and observe that P1 disappears above 20 GeV. The increase with energy of the mean phase of the P3 component can be followed with much greater detail, showing that P3 and P2 are present up to the highest energies of pulsation. We find significant pulsed emission at phases outside the main profile, indicating that magnetospheric emission exists over 80% of the pulsar period. With increased high-energy counts the phase-averaged spectrum is seen to depart from a power law with simple exponential cutoff, and is better fit with a more gradual cutoff. The spectra in fixed-count phase bins are well fit with power laws with exponential cutoffs, revealing a strong and complex phase dependence of the cutoff energy, especially in the peaks. Finally, by combining these results with predictions of the outer magnetosphere models that map emission characteristics to phase, it will be possible to probe the particle acceleration and the structure of the pulsar magnetosphere with unprecedented detail.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3126262','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3126262"><span>The Role of <span class="hlt">LAT</span> in Increased CD8+ T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1▿</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Allen, Sariah J.; Hamrah, Pedram; Gate, David; Mott, Kevin R.; Mantopoulos, Dimosthenis; Zheng, Lixin; Town, Terrence; Jones, Clinton; von Andrian, Ulrich H.; Freeman, Gordon J.; Sharpe, Arlene H.; BenMohamed, Lbachir; Ahmed, Rafi; Wechsler, Steven L.; Ghiasi, Homayon</p> <p>2011-01-01</p> <p>Herpes simplex virus (HSV) infection is a classic example of latent viral infection in humans and experimental animal models. The HSV-1 latency-associated transcript (<span class="hlt">LAT</span>) plays a major role in the HSV-1 latency reactivation cycle and thus in recurrent disease. Whether the presence of <span class="hlt">LAT</span> leads to generation of dysfunctional T cell responses in the trigeminal ganglia (TG) of latently infected mice is not known. To address this issue, we used <span class="hlt">LAT</span>-positive [<span class="hlt">LAT</span>(+)] and <span class="hlt">LAT</span>-deficient [<span class="hlt">LAT</span>(−)] viruses to evaluate the effect of <span class="hlt">LAT</span> on CD8 T cell exhaustion in TG of latently infected mice. The amount of latency as determined by quantitative reverse transcription-PCR (qRT-PCR) of viral DNA in total TG extracts was 3-fold higher with <span class="hlt">LAT</span>(+) than with <span class="hlt">LAT</span>(−) virus. <span class="hlt">LAT</span> expression and increased latency correlated with increased mRNA levels of CD8, PD-1, and Tim-3. PD-1 is both a marker for exhaustion and a primary factor leading to exhaustion, and Tim-3 can also contribute to exhaustion. These results suggested that <span class="hlt">LAT</span>(+) TG contain both more CD8+ T cells and more CD8+ T cells expressing the exhaustion markers PD-1 and Tim-3. This was confirmed by flow cytometry analyses of expression of CD3/CD8/PD-1/Tim-3, HSV-1, CD8+ T cell pentamer (specific for a peptide derived from residues 498 to 505 of glycoprotein B [gB498–505]), interleukin-2 (IL-2), and tumor necrosis factor alpha (TNF-α). The functional significance of PD-1 and its ligands in HSV-1 latency was demonstrated by the significantly reduced amount of HSV-1 latency in PD-1- and PD-L1-deficient mice. Together, these results may suggest that both PD-1 and Tim-3 are mediators of CD8+ T cell exhaustion and latency in HSV-1 infection. PMID:21307196</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19855327','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19855327"><span>Electromyographic analysis of three different types of <span class="hlt">lat</span> pull-down.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sperandei, Sandro; Barros, Marcos A P; Silveira-Júnior, Paulo C S; Oliveira, Carlos G</p> <p>2009-10-01</p> <p>The purpose of this work was to evaluate the activity of the primary motor muscles during the performance of 3 <span class="hlt">lat</span> pull-down techniques through surface electromyography (EMG). Twenty-four trained adult men performed 5 repetitions of behind-the-neck (BNL), front-of-the-neck (FNL), and V-bar exercises at 80% of 1 repetition maximum. For each technique, the root mean square from the EMG signal was registered from the pectoralis major (PM), latissimus dorsi (LD), posterior deltoid (PD), and biceps brachii (BB) and further normalized in respect to that which presented the highest value of all the techniques. A series of two-way repeated measures analysis of variance was used to compare the results, with Tukey-Kramer as the post hoc test and alpha = 0.05. During the concentric phase, PM value showed the FNL to be significantly higher than V-bar/BNL and V-bar higher than BNL. During the eccentric phase, FNL/V-bar was higher than BNL. For LD, there was no difference between techniques. PD presented BNL higher than FNL/V-bar and FNL higher than V-bar in the concentric phase and BNL higher than V-bar in the eccentric phase. BB exhibited BNL higher than V-bar/FNL and V-bar higher than FNL in both concentric and eccentric phases. Considering the main objectives of <span class="hlt">lat</span> pull-down, we concluded that FNL is the better choice, whereas BNL is not a good <span class="hlt">lat</span> pull-down technique and should be avoided. V-bar could be used as an alternative.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1356721-adaptive-binning-method-generating-constant-uncertainty-constant-significance-light-curves-fermi-lat-data','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1356721-adaptive-binning-method-generating-constant-uncertainty-constant-significance-light-curves-fermi-lat-data"><span>An adaptive-binning method for generating constant-uncertainty/constant-significance light curves with Fermi -<span class="hlt">LAT</span> data</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Lott, B.; Escande, L.; Larsson, S.; ...</p> <p>2012-07-19</p> <p>Here, we present a method enabling the creation of constant-uncertainty/constant-significance light curves with the data of the Fermi-Large Area Telescope (<span class="hlt">LAT</span>). The adaptive-binning method enables more information to be encapsulated within the light curve than with the fixed-binning method. Although primarily developed for blazar studies, it can be applied to any sources. Furthermore, this method allows the starting and ending times of each interval to be calculated in a simple and quick way during a first step. The reported mean <span class="hlt">flux</span> and spectral index (assuming the spectrum is a power-law distribution) in the interval are calculated via the standard LATmore » analysis during a second step. In the absence of major caveats associated with this method Monte-Carlo simulations have been established. We present the performance of this method in determining duty cycles as well as power-density spectra relative to the traditional fixed-binning method.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017ApJ...837...13P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017ApJ...837...13P"><span>Seven-year Collection of Well-monitored Fermi-<span class="hlt">LAT</span> Gamma-Ray Burst Afterglows</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Panaitescu, A.</p> <p>2017-03-01</p> <p>We present the light curves and spectra of 24 afterglows that have been monitored by Fermi-<span class="hlt">LAT</span> at 0.1-100 GeV over more than a decade. All light curves (except 130427) are consistent with a single power law starting from their peaks, which occur in most cases before the burst end. The light curves display a brightness-decay rate correlation, with all but one (130427) of the bright afterglows decaying faster than the dimmer afterglows. We attribute this dichotomy to the quick deposition of relativistic ejecta energy in the external shock for the brighter/faster-decaying afterglows and to an extended energy injection in the afterglow shock for the dimmer/slower-decaying light curves. The spectra of six afterglows (090328, 100414, 110721, 110731, 130427, 140619B) indicate the existence of a harder component above a spectral dip or ankle at energies of 0.3-3 GeV, offering evidence for inverse-Compton emission at higher energies and suggesting that the harder power-law spectra of five other <span class="hlt">LAT</span> afterglows (130327B, 131231, 150523, 150627, 160509) could also be inverse-Compton, while the remaining, softer <span class="hlt">LAT</span> afterglows should be synchrotron emission. Marginal evidence for a spectral break and softening at higher energies is found for two afterglows (090902B and 090926).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29535383','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29535383"><span>A <span class="hlt">LATS</span> biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Azad, T; Janse van Rensburg, H J; Lightbody, E D; Neveu, B; Champagne, A; Ghaffari, A; Kay, V R; Hao, Y; Shen, H; Yeung, B; Croy, B A; Guan, K L; Pouliot, F; Zhang, J; Nicol, C J B; Yang, X</p> <p>2018-03-13</p> <p>The Hippo pathway is a central regulator of tissue development and homeostasis, and has been reported to have a role during vascular development. Here we develop a bioluminescence-based biosensor that monitors the activity of the Hippo core component <span class="hlt">LATS</span> kinase. Using this biosensor and a library of small molecule kinase inhibitors, we perform a screen for kinases modulating <span class="hlt">LATS</span> activity and identify VEGFR as an upstream regulator of the Hippo pathway. We find that VEGFR activation by VEGF triggers PI3K/MAPK signaling, which subsequently inhibits <span class="hlt">LATS</span> and activates the Hippo effectors YAP and TAZ. We further show that the Hippo pathway is a critical mediator of VEGF-induced angiogenesis and tumor vasculogenic mimicry. Thus, our work offers a biosensor tool for the study of the Hippo pathway and suggests a role for Hippo signaling in regulating blood vessel formation in physiological and pathological settings.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JGRA..123.1191B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JGRA..123.1191B"><span>Variations of the <span class="hlt">Electron</span> <span class="hlt">Fluxes</span> in the Terrestrial Radiation Belts Due To the Impact of Corotating Interaction Regions and Interplanetary Coronal Mass Ejections</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Benacquista, R.; Boscher, D.; Rochel, S.; Maget, V.</p> <p>2018-02-01</p> <p>In this paper, we study the variations of the radiation belts <span class="hlt">electron</span> <span class="hlt">fluxes</span> induced by the interaction of two types of solar wind structures with the Earth magnetosphere: the corotating interaction regions and the interplanetary coronal mass ejections. We use a statistical method based on the comparison of the preevent and postevent <span class="hlt">fluxes</span>. Applied to the National Oceanic and Atmospheric Administration-Polar Operational Environmental Satellites data, this gives us the opportunity to extend previous studies focused on relativistic <span class="hlt">electrons</span> at geosynchronous orbit. We enlighten how corotating interaction regions and Interplanetary Coronal Mass Ejections can impact differently the <span class="hlt">electron</span> belts depending on the energy and the L shell. In addition, we provide a new insight concerning these variations by considering their amplitude. Finally, we show strong relations between the intensity of the magnetic storms related to the events and the variation of the <span class="hlt">flux</span>. These relations concern both the capacity of the events to increase the <span class="hlt">flux</span> and the deepness of these increases.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1354852-spectral-analysis-fermi-lat-blazars-above-gev','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1354852-spectral-analysis-fermi-lat-blazars-above-gev"><span>SPECTRAL ANALYSIS OF FERMI -<span class="hlt">LAT</span> BLAZARS ABOVE 50 GEV</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Domínguez, Alberto; Ajello, Marco</p> <p>2015-11-04</p> <p>We present an analysis of the intrinsic (unattenuated by the extragalactic background light, EBL) power-law spectral indices of 128 extragalactic sources detected up to z ~ 2 with the Fermi-Large Area Telescope (<span class="hlt">LAT</span>) at very high energies (VHEs, E ≥50 GeV). The median of the intrinsic index distribution is 2.20 (versus 2.54 for the observed distribution). We also analyze the observed spectral breaks (i.e., the difference between the VHE and high energy, HE, 100 MeV ≤ E ≤ 300 GeV, spectral indices). The Fermi-<span class="hlt">LAT</span> has now provided a large sample of sources detected both at VHE and HE with comparablemore » exposure that allows us to test models of extragalactic γ-ray photon propagation. We find that our data are compatible with simulations that include intrinsic blazar curvature and EBL attenuation. There is also no evidence of evolution with redshift of the physics that drives the photon emission in high-frequency synchrotron peak (HSP) blazars. This makes HSP blazars excellent probes of the EBL.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19970025515','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19970025515"><span>Achieving Zero Current for Polar Wind Outflow on Open <span class="hlt">Flux</span> Tubes Subjected to Large Photoelectron <span class="hlt">Fluxes</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Wilson, G. R.; Khazanov, G.; Horwitz, J. L.</p> <p>1997-01-01</p> <p>In this study we investigate how the condition of zero current on open <span class="hlt">flux</span> tubes with polar wind outflow, subjected to large photoelectron <span class="hlt">fluxes</span>, can be achieved. We employ a steady state collisionless semikinetic model to determine the density profiles of O(+), H(+), thermal <span class="hlt">electrons</span> and photoelectrons coming from the ionosphere along with H(+), ions and <span class="hlt">electrons</span> coming from the magnetosphere. The model solution attains a potential distribution which both satisfies the condition of charge neutrality and zero current. For the range of parameters considered in this study we find that a 45-60 volt discontinuous potential drop may develop to reflect most of the photoelectrons back toward the ionosphere. This develops because the downward <span class="hlt">flux</span> of <span class="hlt">electrons</span> from the magnetosphere to the ionosphere on typical open <span class="hlt">flux</span> tubes (e.g. the polar rain) appears to be insufficient to balance the photoelectron <span class="hlt">flux</span> from the ionosphere.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012ApJ...755..118A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012ApJ...755..118A"><span>Multiwavelength Observations of the AGN 1ES 0414+009 with VERITAS, Fermi-<span class="hlt">LAT</span>, Swift-XRT, and MDM</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Aliu, E.; Archambault, S.; Arlen, T.; Aune, T.; Beilicke, M.; Benbow, W.; Böttcher, M.; Bouvier, A.; Bugaev, V.; Cannon, A.; Cesarini, A.; Ciupik, L.; Collins-Hughes, E.; Connolly, M. P.; Cui, W.; Dickherber, R.; Dumm, J.; Errando, M.; Falcone, A.; Federici, S.; Feng, Q.; Finley, J. P.; Finnegan, G.; Fortson, L.; Furniss, A.; Galante, N.; Gall, D.; Godambe, S.; Griffin, S.; Grube, J.; Gyuk, G.; Hanna, D.; Holder, J.; Huan, H.; Hughes, G.; Hui, C. M.; Imran, A.; Jameil, O.; Kaaret, P.; Karlsson, N.; Kertzman, M.; Kerr, J.; Khassen, Y.; Kieda, D.; Krawczynski, H.; Krennrich, F.; Lang, M. J.; Lee, K.; Madhavan, A. S.; Majumdar, P.; McArthur, S.; McCann, A.; Moriarty, P.; Mukherjee, R.; Nelson, T.; O'Faoláin de Bhróithe, A.; Ong, R. A.; Orr, M.; Otte, A. N.; Park, N.; Perkins, J. S.; Pichel, A.; Pohl, M.; Quinn, J.; Ragan, K.; Reynolds, P. T.; Roache, E.; Ruppel, J.; Saxon, D. B.; Schroedter, M.; Sembroski, G. H.; Şentürk, G. D.; Smith, A. W.; Staszak, D.; Stroh, M.; Telezhinsky, I.; Tešić, G.; Theiling, M.; Thibadeau, S.; Tsurusaki, K.; Varlotta, A.; Vassiliev, V. V.; Vivier, M.; Wakely, S. P.; Ward, J. E.; Weinstein, A.; Welsing, R.; Williams, D. A.; Zitzer, B.</p> <p>2012-08-01</p> <p>We present observations of the BL Lac object 1ES 0414+009 in the >200 GeV gamma-ray band by the VERITAS array of Cherenkov telescopes. 1ES 0414+009 was observed by VERITAS between 2008 January and 2011 February, resulting in 56.2 hr of good quality pointed observations. These observations resulted in a detection of 822 events from the source corresponding to a statistical significance of 6.4 standard deviations (6.4σ) above the background. The source <span class="hlt">flux</span>, showing no evidence for variability, is measured as (5.2 ± 1.1stat ± 2.6sys) × 10-12 photons cm-2 s-1 above 200 GeV, equivalent to approximately 2% of the Crab Nebula <span class="hlt">flux</span> above this energy. The differential photon spectrum from 230 GeV to 850 GeV is well fit by a power law with a photon index of Γ = 3.4 ± 0.5stat ± 0.3sys and a <span class="hlt">flux</span> normalization of (1.6 ± 0.3stat ± 0.8sys) × 10-11 photons cm-2 s-1 at 300 GeV. We also present multiwavelength results taken in the optical (MDM), x-ray (Swift-XRT), and GeV (Fermi-<span class="hlt">LAT</span>) bands and use these results to construct a broadband spectral energy distribution (SED). Modeling of this SED indicates that homogenous one-zone leptonic scenarios are not adequate to describe emission from the system, with a lepto-hadronic model providing a better fit to the data.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/26944194','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/26944194"><span>Aryl hydrocarbon receptor (AHR) regulation of L-Type Amino Acid Transporter 1 (<span class="hlt">LAT</span>-1) expression in MCF-7 and MDA-MB-231 breast cancer cells.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tomblin, Justin K; Arthur, Subha; Primerano, Donald A; Chaudhry, Ateeq R; Fan, Jun; Denvir, James; Salisbury, Travis B</p> <p>2016-04-15</p> <p>The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is regulated by environmental toxicants that function as AHR agonists such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). L-Type Amino Acid Transporter 1 (<span class="hlt">LAT</span>1) is a leucine transporter that is overexpressed in cancer. The regulation of <span class="hlt">LAT</span>1 by AHR in MCF-7 and MDA-MB-231 breast cancer cells (BCCs) was investigated in this report. Ingenuity pathway analysis (IPA) revealed a significant association between TCDD-regulated genes (TRGs) and molecular transport. Overlapping the TCDD-RNA-Seq dataset obtained in this study with a published TCDD-ChIP-seq dataset identified <span class="hlt">LAT</span>1 as a primary target of AHR-dependent TCDD induction. Short interfering RNA (siRNA)-directed knockdown of AHR confirmed that TCDD-stimulated increases in <span class="hlt">LAT</span>1 mRNA and protein required AHR expression. TCDD-stimulated increases in <span class="hlt">LAT</span>1 mRNA were also inhibited by the AHR antagonist CH-223191. Upregulation of <span class="hlt">LAT</span>1 by TCDD coincided with increases in leucine uptake by MCF-7 cells in response to TCDD. Chromatin immunoprecipitation-quantitative PCR (ChIP-qPCR) assays revealed increases in AHR, AHR nuclear translocator (ARNT) and p300 binding and histone H3 acetylation at an AHR binding site in the <span class="hlt">LAT</span>1 gene in response to TCDD. In MCF-7 and MDA-MB-231 cells, endogenous levels of <span class="hlt">LAT</span>1 mRNA and protein were reduced in response to knockdown of AHR expression. Knockdown experiments demonstrated that proliferation of MCF-7 and MDA-MB-231 cells is dependent on both <span class="hlt">LAT</span>1 and AHR. Collectively, these findings confirm the dependence of cancer cells on leucine uptake and establish a mechanism for extrinsic and intrinsic regulation of <span class="hlt">LAT</span>1 by AHR. Copyright © 2016 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/8305449','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/8305449"><span>Partitioning of <span class="hlt">electron</span> <span class="hlt">flux</span> between the respiratory chains of the yeast Candida parapsilosis: parallel working of the two chains.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Guerin, M G; Camougrand, N M</p> <p>1994-02-08</p> <p>Partitioning of the <span class="hlt">electron</span> <span class="hlt">flux</span> between the classical and the alternative respiratory chains of the yeast Candida parapsilosis, was measured as a function of the oxidation rate and of the Q-pool redox poise. At low respiration rate, <span class="hlt">electrons</span> from external NADH travelled preferentially through the alternative pathway as indicated by the antimycin A-insensitivity of <span class="hlt">electron</span> flow. Inhibition of the alternative pathway by SHAM restored full antimycin A-sensitivity to the remaining electro flow. The dependence of the respiratory rate on the redox poise of the quinone pool was investigated when the <span class="hlt">electron</span> <span class="hlt">flux</span> was mediated either by the main respiratory chain (growth in the absence of antimycin A) or by the second respiratory chain (growth in the presence of antimycin A). In the former case, a linear relationship was found between these two parameters. In contrast, in the latter case, the relationship between Q-pool reduction level and <span class="hlt">electron</span> <span class="hlt">flux</span> was non-linear, but it could be resolved into two distinct curves. This second quinone is not reducible in the presence of antimycin A but only in the presence of high concentrations of myxothiazol or cyanide. Since two quinone species exist in C. parapsilosis, UQ9 and Qx (C33H54O4), we hypothesized that these two curves could correspond to the functioning of the second quinone engaged during the alternative pathway activity. Partitioning of <span class="hlt">electrons</span> between both respiratory chains could occur upstream of complex III with the second chain functioning in parallel to the main one, and with the additional possibility of merging into the main one at the complex IV level.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24661742','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24661742"><span>Cap and trade schemes on waste management: a case study of the landfill allowance trading scheme (<span class="hlt">LATS</span>) in England.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Calaf-Forn, Maria; Roca, Jordi; Puig-Ventosa, Ignasi</p> <p>2014-05-01</p> <p>The Landfill Allowance Trading Scheme (<span class="hlt">LATS</span>) is one of the main instruments used in England to enforce the landfill diversion targets established in the Directive 1999/31/EC of the European Parliament and of the Council of 26 April 1999 on the landfill of waste (Landfill Directive). Through the <span class="hlt">LATS</span>, biodegradable municipal waste (BMW) allowances for landfilling are allocated to each local authority, otherwise known as waste disposal authorities (WDAs). The quantity of landfill allowances received is expected to decrease continuously from 2005/06 to 2019/20 so as to meet the objectives of the Landfill Directive. To achieve their commitments, WDAs can exchange, buy, sell or transfer allowances among each other, or may re-profile their own allocation through banking and/or borrowing. Despite the goals for the first seven years - which included two target years (2005/06 and 2009/10) - being widely achieved (the average allocation of allowances per WDA was 22.9% higher than those finally used), market activity among WDAs was high and prices were not very stable. Results in terms of waste reduction and recycling levels have been satisfactory. The reduction of BMW landfilled (in percentage) was higher during the first seven years of the <span class="hlt">LATS</span> period (2005/06-2011/12) (around 7% annually) than during the previous period (2001/02-2004/05) (4.2% annually). Since 2008, the significance of the <span class="hlt">LATS</span> diminished because of an increase in the rate of the UK Landfill Tax. The <span class="hlt">LATS</span> was suppressed after the 2012/13 target year, before what it was initially scheduled. The purpose of this paper is to describe the particularities of the <span class="hlt">LATS</span>, analyse its performance as a waste management policy, make a comparison with the Landfill Tax, discuss its main features as regards efficiency, effectiveness and the application of the "polluter pays" principle and finally discuss if the effect of the increase in the Landfill Tax is what made the <span class="hlt">LATS</span> ultimately unnecessary. Copyright © 2014</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018ATel11546....1J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018ATel11546....1J"><span>Fermi-<span class="hlt">LAT</span> Bright Gamma-ray Detection of Nova ASASSN-18fv</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Jean, P.; Cheung, C. C.; Ojha, R.; van Zyl, P.; Angioni, R.</p> <p>2018-04-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), one of two instruments on the Fermi Gamma-ray Space Telescope, has observed bright gamma-ray emission from a source positionally consistent with the bright optical nova ASASSN-18fv (ATel #11454, #11456, #11460, #11467, #11508).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016NPPP..273.2351G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016NPPP..273.2351G"><span><span class="hlt">Electron</span>/proton separation and analysis techniques used in the AMS-02 (e+ + e-) <span class="hlt">flux</span> measurement</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Graziani, Maura; AMS-02 Collaboration</p> <p>2016-04-01</p> <p>AMS-02 is a large acceptance cosmic ray detector which has been installed on the International Space Station (ISS) in May 2011, where it is collecting cosmic rays up to TeV energies. The search for Dark Matter indirect signatures in the rare components of the cosmic ray <span class="hlt">fluxes</span> is among the main objectives of the experiment. AMS-02 is providing cosmic <span class="hlt">electrons</span> and positrons data with an unprecedented precision. This is achieved by means to the excellent hadron/<span class="hlt">electron</span> separation power obtained combining the independent measurements from the Transition Radiation Detector, electromagnetic Calorimeter and Tracker detectors. In this contribution we will detail the analysis techniques used to distinguish <span class="hlt">electrons</span> from the hadronic background and show the in-flight performances of these detectors relevant for the <span class="hlt">electron</span>/positron measurements.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1351224-seven-year-collection-well-monitored-fermi-lat-gamma-ray-burst-afterglows','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1351224-seven-year-collection-well-monitored-fermi-lat-gamma-ray-burst-afterglows"><span>Seven-year Collection of Well-monitored Fermi -<span class="hlt">LAT</span> Gamma-Ray Burst Afterglows</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Panaitescu, Alin-Daniel</p> <p>2017-02-27</p> <p>Here we present the light curves and spectra of 24 afterglows that have been monitored by Fermi-<span class="hlt">LAT</span> at 0.1–100 GeV over more than a decade. All light curves (except 130427) are consistent with a single power law starting from their peaks, which occur in most cases before the burst end. The light curves display a brightness–decay rate correlation, with all but one (130427) of the bright afterglows decaying faster than the dimmer afterglows. We attribute this dichotomy to the quick deposition of relativistic ejecta energy in the external shock for the brighter/faster-decaying afterglows and to an extended energy injection inmore » the afterglow shock for the dimmer/slower-decaying light curves. The spectra of six afterglows (090328, 100414, 110721, 110731, 130427, 140619B) indicate the existence of a harder component above a spectral dip or ankle at energies of 0.3–3 GeV, offering evidence for inverse-Compton emission at higher energies and suggesting that the harder power-law spectra of five other <span class="hlt">LAT</span> afterglows (130327B, 131231, 150523, 150627, 160509) could also be inverse-Compton, while the remaining, softer <span class="hlt">LAT</span> afterglows should be synchrotron emission. Finally, marginal evidence for a spectral break and softening at higher energies is found for two afterglows (090902B and 090926).« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1351224','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1351224"><span>Seven-year Collection of Well-monitored Fermi -<span class="hlt">LAT</span> Gamma-Ray Burst Afterglows</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Panaitescu, Alin-Daniel</p> <p></p> <p>Here we present the light curves and spectra of 24 afterglows that have been monitored by Fermi-<span class="hlt">LAT</span> at 0.1–100 GeV over more than a decade. All light curves (except 130427) are consistent with a single power law starting from their peaks, which occur in most cases before the burst end. The light curves display a brightness–decay rate correlation, with all but one (130427) of the bright afterglows decaying faster than the dimmer afterglows. We attribute this dichotomy to the quick deposition of relativistic ejecta energy in the external shock for the brighter/faster-decaying afterglows and to an extended energy injection inmore » the afterglow shock for the dimmer/slower-decaying light curves. The spectra of six afterglows (090328, 100414, 110721, 110731, 130427, 140619B) indicate the existence of a harder component above a spectral dip or ankle at energies of 0.3–3 GeV, offering evidence for inverse-Compton emission at higher energies and suggesting that the harder power-law spectra of five other <span class="hlt">LAT</span> afterglows (130327B, 131231, 150523, 150627, 160509) could also be inverse-Compton, while the remaining, softer <span class="hlt">LAT</span> afterglows should be synchrotron emission. Finally, marginal evidence for a spectral break and softening at higher energies is found for two afterglows (090902B and 090926).« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018PhRvD..97i1701H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018PhRvD..97i1701H"><span>Origins of sharp cosmic-ray <span class="hlt">electron</span> structures and the DAMPE excess</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Huang, Xian-Jun; Wu, Yue-Liang; Zhang, Wei-Hong; Zhou, Yu-Feng</p> <p>2018-05-01</p> <p>Nearby sources may contribute to cosmic-ray <span class="hlt">electron</span> (CRE) structures at high energies. Recently, the first DAMPE results on the CRE <span class="hlt">flux</span> hinted at a narrow excess at energy ˜1.4 TeV . We show that in general a spectral structure with a narrow width appears in two scenarios. The first is spectrum broadening for the continuous sources with a δ -function-like injection spectrum. In this scenario, a finite width can develop after propagation through the Galaxy, which can reveal the distance of the source. Well-motivated sources include minispikes and subhalos formed by dark matter (DM) particles χs which annihilate directly into e+e- pairs. The second is phase-space shrinking for burstlike sources with a power-law-like injection spectrum. The spectrum after propagation can shrink at a cooling-related cutoff energy and form a sharp spectral peak. The peak can be more prominent due to the energy-dependent diffusion. In this scenario, the width of the excess constrains both the power index and the distance of the source. Possible such sources are pulsar wind nebulae (PWNe) and supernova remnants (SNRs). We analysis the DAMPE excess and find that the continuous DM sources should be fairly close within ˜0.3 kpc , and the annihilation cross sections are close to the thermal value. For the burstlike source, the narrow width of the excess suggests that the injection spectrum must be hard with power index significantly less than two, the distance is within ˜(3 - 4 ) kpc , and the age of the source is ˜0.16 Myr . In both scenarios, large anisotropies in the CRE <span class="hlt">flux</span> are predicted. We identify possible candidates of minispike and PWN sources in the current Fermi-<span class="hlt">LAT</span> 3FGL and ATNF catalog, respectively. The diffuse γ -rays from these sources can be well below the Galactic diffuse γ -ray backgrounds and less constrained by the Fermi-<span class="hlt">LAT</span> data, if they are located at the low Galactic latitude regions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/862745','DOE-PATENT-XML'); return false;" href="https://www.osti.gov/servlets/purl/862745"><span>Apparatus for measuring a <span class="hlt">flux</span> of neutrons</span></a></p> <p><a target="_blank" href="http://www.osti.gov/doepatents">DOEpatents</a></p> <p>Stringer, James L.</p> <p>1977-01-01</p> <p>A <span class="hlt">flux</span> of neutrons is measured by disposing a detector in the <span class="hlt">flux</span> and applying <span class="hlt">electronic</span> correlation techniques to discriminate between the electrical signals generated by the neutron detector and the unwanted interfering electrical signals generated by the incidence of a neutron <span class="hlt">flux</span> upon the cables connecting the detector to the <span class="hlt">electronic</span> measuring equipment at a remote location.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li class="active"><span>15</span></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_15 --> <div id="page_16" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active"><span>16</span></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="301"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018ChPhC..42b5102Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018ChPhC..42b5102Z"><span>Searching for γ-ray emission from Reticulum II by Fermi-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zhao, Yi; Bi, Xiao-Jun; Yin, Peng-Fei; Zhang, Xinmin</p> <p>2018-02-01</p> <p>Recently, many new dwarf spheroidal satellites (dSphs) have been discovered by the Dark Energy Survey (DES). These dSphs are ideal candidates for probing for gamma-ray emissions from dark matter (DM) annihilation. However, no significant signature has been found by the Fermi-<span class="hlt">LAT</span> dSph observations. In this work, we reanalyze the Fermi-<span class="hlt">LAT</span> Pass 8 data from the direction of Reticulum II, where a slight excess has been reported by some previous studies. We treat Reticulum II (DES J0335.6-5403) as a spatially extended source, and find that no significant gamma-ray signature is observed. Based on this result, we set upper-limits on the DM annihilation cross section. Supported by National Natural Science Foundation of China (11121092, 11033005, 11375202, 11475191, 11475189), the CAS pilot B program (XDB23020000) and the National Key Program for Research and Development (2016YFA0400200)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015APS..DPPJO5002H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015APS..DPPJO5002H"><span>Heat-<span class="hlt">Flux</span> Measurements from Collective Thomson-Scattering Spectra</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Henchen, R. J.; Hu, S. X.; Katz, J.; Froula, D. H.; Rozmus, W.</p> <p>2015-11-01</p> <p>Collective Thomson scattering was used to measure heat <span class="hlt">flux</span> in coronal plasmas. The relative amplitude of the Thomson-scattered power into the up- and downshifted <span class="hlt">electron</span> plasma wave features was used to determine the <span class="hlt">flux</span> of <span class="hlt">electrons</span> moving along the temperature gradient at three to four times the <span class="hlt">electron</span> thermal velocity. Simultaneously, the ion-acoustic wave features were measured. Their relative amplitude is used to measure the <span class="hlt">flux</span> of the return-current <span class="hlt">electrons</span>. The frequencies of these ion-acoustic and <span class="hlt">electron</span> plasma wave features provide local measurements of the <span class="hlt">electron</span> temperature and density. These spectra were obtained at five locations along the temperature gradient in a laser-produced blowoff plasma. These measurements of plasma parameters are used to infer the Spitzer -Härm <span class="hlt">flux</span> <m:mfenced close=")" open="(" separators="">qSH = - κ∇Te </m:mfenced> and are in good agreement with the values of the heat <span class="hlt">flux</span> measured from the scattering-feature asymmetries. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1357203-cross-correlation-study-fermi-lat-ray-diffuse-extragalactic-signal','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1357203-cross-correlation-study-fermi-lat-ray-diffuse-extragalactic-signal"><span>A cross-correlation study of the Fermi-<span class="hlt">LAT</span> γ-ray diffuse extragalactic signal</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Xia, Jun -Qing; Cuoco, Alessandro; Branchini, Enzo; ...</p> <p>2011-09-12</p> <p>In this work, starting from 21 months of data from the Fermi Large Area Telescope (<span class="hlt">LAT</span>), we derive maps of the residual isotropic γ-ray emission, a relevant fraction of which is expected to be contributed by the extragalactic diffuse γ-ray background (EGB). We search for the auto-correlation signals in the above γ-ray maps and for the cross-correlation signal with the angular distribution of different classes of objects that trace the large-scale structure of the Universe. We compute the angular two-point auto-correlation function of the residual Fermi-<span class="hlt">LAT</span> maps at energies E > 1 GeV, E > 3 GeV and E >more » 30 GeV well above the Galactic plane and find no significant correlation signal. This is, indeed, what is expected if the EGB were contributed by BL Lacertae (BLLacs), Flat Spectrum Radio Quasars (FSRQs) or star-forming galaxies, since, in this case, the predicted signal is very weak. Then, we search for the Integrated Sachs–Wolfe (ISW) signature by cross-correlating the Fermi-<span class="hlt">LAT</span> maps with the 7-year Wilkinson Microwave Anisotropy Probe ( WMAP7) cosmic microwave background map. We find a cross-correlation consistent with zero, even though the expected signal is larger than that of the EGB auto-correlation. Lastly, in an attempt to constrain the nature of the γ-ray background, we cross-correlate the Fermi-<span class="hlt">LAT</span> maps with the angular distributions of objects that may contribute to the EGB: quasi-stellar objects (QSOs) in the Sloan Digital Sky Survey Data Release 6 (SDSS-DR6) catalogue, NRAO VLA Sky Survey (NVSS) galaxies, Two Micron All Sky Survey (2MASS) galaxies and Luminous Red Galaxies (LRGs) in the SDSS catalogue. The cross-correlation is always consistent with zero, in agreement with theoretical expectations, but we find (with low statistical significance) some interesting features that may indicate that some specific classes of objects contribute to the EGB. A χ 2 analysis confirms that the correlation properties of the 21-month data do not provide</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19920059359&hterms=dropout&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Ddropout','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19920059359&hterms=dropout&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Ddropout"><span>Interplanetary magnetic field connection to the sun during <span class="hlt">electron</span> heat <span class="hlt">flux</span> dropouts in the solar wind</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Lin, R. P.; Kahler, S. W.</p> <p>1992-01-01</p> <p>The paper discusses observations of 2- to 8.5-keV <span class="hlt">electrons</span>, made by measurements aboard the ISEE 3 spacecraft during the periods of heat <span class="hlt">flux</span> decreases (HFDs) reported by McComas et al. (1989). In at least eight of the total of 25 HFDs observed, strong streaming of <span class="hlt">electrons</span> that were equal to or greater than 2 keV outward from the sun was recorded. In one HFD, an impulsive solar <span class="hlt">electron</span> event was observed with an associated type III radio burst, which could be tracked from the sun to about 1 AU. It is concluded that, in many HFDs, the interplanetary field is still connected to the sun and that some energy-dependent process may produce HFDs without significantly perturbing <span class="hlt">electrons</span> of higher energies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20120009947&hterms=polarimetry&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dpolarimetry','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20120009947&hterms=polarimetry&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dpolarimetry"><span>Characteristics of Gamma-Ray Loud Blazars in the VLBA Imaging and Polarimetry Survey</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Linford, J. D.; Taylor, G. B.; Romani, R. W.; Healey, S. E.; Helmboldt, J. F.; Readhead, A. C.; Reeves, R.; Richards, J. L.; Cotter, G.</p> <p>2010-01-01</p> <p>The radio properties of blazars detected by the Large Area Telescope (<span class="hlt">LAT</span>) on board the Fermi Gamma-ray Space Telescope have been observed as part of the VLBA Imaging and Polarimetry Survey. This large, <span class="hlt">flux</span>-limited sample of active galactic nuclei (AGNs) provides insights into the mechanism that produces strong gamma-ray emission. At lower <span class="hlt">flux</span> levels, radio <span class="hlt">flux</span> density does not directly correlate with gamma-ray <span class="hlt">flux</span>. We find that the <span class="hlt">LAT</span>-detected BL Lac objects tend to be similar to the non-<span class="hlt">LAT</span> BL Lac objects, but that the <span class="hlt">LAT</span>-detected FSRQs are often significantly different from the non-<span class="hlt">LAT</span> FSRQs. The differences between the gamma-ray loud and quiet FSRQS can be explained by Doppler boosting; these objects appear to require larger Doppler factors than those of the BL Lac objects. It is possible that the gamma-ray loud FSRQs are fundamentally different from the gamma-ray quiet FSRQs. Strong polarization at the base of the jet appears to be a signature for gamma-ray loud AGNs.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014PhDT.......119R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014PhDT.......119R"><span>Oxygen <span class="hlt">flux</span> and dielectric response study of Mixed Ionic-<span class="hlt">Electronic</span> Conducting (MIEC) heterogeneous functional materials</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Rabbi, Fazle</p> <p></p> <p>Dense mixed ionic-<span class="hlt">electronic</span> conducting (MIEC) membranes consisting of ionic conductive perovskite-type and/or fluorite-type oxides and high <span class="hlt">electronic</span> conductive spinel type oxides, at elevated temperature can play a useful role in a number of energy conversion related systems including the solid oxide fuel cell (SOFC), oxygen separation and permeation membranes, partial oxidization membrane reactors for natural gas processing, high temperature electrolysis cells, and others. This study will investigate the impact of different heterogeneous characteristics of dual phase ionic and <span class="hlt">electronic</span> conductive oxygen separation membranes on their transport mechanisms, in an attempt to develop a foundation for the rational design of such membranes. The dielectric behavior of a material can be an indicator for MIEC performance and can be incorporated into computational models of MIEC membranes in order to optimize the composition, microstructure, and ultimately predict long term membrane performance. The dielectric behavior of the MIECs can also be an indicator of the transport mechanisms and the parameters they are dependent upon. For this study we chose a dual phase MIEC oxygen separation membrane consisting of an ionic conducting phase: gadolinium doped ceria-Ce0.8 Gd0.2O2 (GDC) and an <span class="hlt">electronic</span> conductive phase: cobalt ferrite-CoFe2O4 (CFO). The membranes were fabricated from mixtures of Nano-powder of each of the phases for different volume percentages, sintered with various temperatures and sintering time to form systematic micro-structural variations, and characterized by structural analysis (XRD), and micro-structural analysis (SEM-EDS). Performance of the membranes was tested for variable partial pressures of oxygen across the membrane at temperatures from 850°C-1060°C using a Gas Chromatography (GC) system. Permeated oxygen did not directly correlate with change in percent mixture. An intermediate mixture 60%GDC-40%CFO had the highest <span class="hlt">flux</span> compared to the 50%GDC</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016NPPP..273.2348C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016NPPP..273.2348C"><span>Inert Higgs Doublet Dark Matter in Type-II Seesaw</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Chen, Chuan-Hung; Nomura, Takaaki</p> <p>2016-04-01</p> <p>Weakly interacting massive particle (WIMP) as a dark matter (DM) candidate is further inspired by recent AMS-02 data, which confirm the excess of positron fraction observed earlier by PAMELA and Fermi-<span class="hlt">LAT</span> experiments. Additionally, the excess of positron+<span class="hlt">electron</span> <span class="hlt">flux</span> is still significant in the measurement of Fermi-<span class="hlt">LAT</span>. For solving the problem of massive neutrinos and observed excess of cosmic-ray by DM annihilation, we study the model with an inert Higgs doublet (IHD) in the framework of type-II seesaw mechanism by imposing a Z2 symmetry on the IHD, where the lightest particle of IHD is the DM candidate while the neutrino masses origin from the Higgs triplet in type-II seesaw model. We calculate the cosmic-ray production in our model and find that if leptonic triplet decays are dominant, the observed excess of positron/<span class="hlt">electron</span> <span class="hlt">flux</span> could be explained well in normal ordered neutrino mass spectrum, when the constraints of DM relic density and comic-ray antiproton spectrum are taken into account.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1990Icar...85..216B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1990Icar...85..216B"><span>Auroral and photoelectron <span class="hlt">fluxes</span> in cometary ionospheres</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bhardwaj, A.; Haider, S. A.; Spinghal, R. P.</p> <p>1990-05-01</p> <p>The analytical yield spectrum method has been used to ascertain photoelectron and auroral <span class="hlt">electron</span> <span class="hlt">fluxes</span> in cometary ionospheres, with a view to determining the effects of cometocentric distances, solar zenith angle, and solar minimum and maximum conditions. Auroral <span class="hlt">electron</span> <span class="hlt">fluxes</span> are thus calculated for monoenergetic and observed primary <span class="hlt">electron</span> spectra; auroral <span class="hlt">electrons</span> are found to make a larger contribution to the observed <span class="hlt">electron</span> spectrum than EUV-generated photoelectrons. Good agreement is established with extant theoretical works.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20130012838','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20130012838"><span>Multiwavelength Observations of the AGN 1ES 0414+009 with Veritas, Fermi-<span class="hlt">LAT</span>, Swift-XRT, and MDM</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Aliu, E.; Archambault, S.; Arlen, T.; Aune, T.; Beilicke, M.; Benbow, W.; Boettcher, M.; Bouvier, A.; Bugaev, V.; Cannon, A.; <a style="text-decoration: none; " href="javascript:void(0); " onClick="displayelement('author_20130012838'); toggleEditAbsImage('author_20130012838_show'); toggleEditAbsImage('author_20130012838_hide'); "> <img style="display:inline; width:12px; height:12px; " src="images/arrow-up.gif" width="12" height="12" border="0" alt="hide" id="author_20130012838_show"> <img style="width:12px; height:12px; display:none; " src="images/arrow-down.gif" width="12" height="12" border="0" alt="hide" id="author_20130012838_hide"></p> <p>2012-01-01</p> <p>We present observations of the BL Lac object 1ES 0414+009 in the greater than 200 GeV gamma-ray band by the VERITAS array of Cherenkov telescopes. 1ES 0414+009 was observed by VERITAS between January 2008 and February 2011, resulting in 56.2 hours of good quality pointed observations. These observations resulted in a detection of 822 events from the source corresponding to a statistical significance of 6.4 standard deviations (6.4 sigma) above the background. The source <span class="hlt">flux</span>, showing no evidence for variability, is measured as (5.2 plus or minus 1.1(sub stat) plus or minus 2.6(sub sys) x 10(exp 12) photons per square centimeter per second above 200 GeV, equivalent to approximately 2% of the Crab Nebula <span class="hlt">flux</span> above this energy. The differential photon spectrum from 230 GeV to 850 GeV is well fit by a power law with an photon index of TAU = 3.4 plus or minus 0.5(sub stat) plus or minus 0.3(sub sys) and a <span class="hlt">flux</span> normalization of (1.6 plus or minus 0.3(sub stat) plus or minus 0.8(sub sys) x 10(exp -11) photons per square centimeter per second at 300 GeV. We also present multiwavelength results taken in the optical (MDM), X-ray (Swift-XRT), and GeV (Fermi-<span class="hlt">LAT</span>) bands and use these results to construct a broadband spectral energy distribution (SED). Modeling of this SED indicates that homogenous one-zone leptonic scenarios are not adequate to describe emission from the system, with a lepto-hadronic model providing a better fit to the data.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1357421-fermi-large-area-telescope-gamma-ray-detection-radio-galaxy-m87','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1357421-fermi-large-area-telescope-gamma-ray-detection-radio-galaxy-m87"><span>FERMI Large Area Telescope Gamma-Ray Detection of the Radio Galaxy M87</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Abdo, A. A.; Ackermann, M.; Ajello, M.; ...</p> <p>2009-11-17</p> <p>Here, we report the Fermi Large Area Telescope (<span class="hlt">LAT</span>) discovery of high-energy (MeV/GeV) γ-ray emission positionally consistent with the center of the radio galaxy M87, at a source significance of over 10σ in 10 months of all-sky survey data. Following the detections of Cen A and Per A, this makes M87 the third radio galaxy seen with the <span class="hlt">LAT</span>. The faint point-like γ-ray source has a >100 MeV <span class="hlt">flux</span> of 2.45 (±0.63) × 10 –8 photons cm –2 s –1 (photon index = 2.26 ± 0.13) with no significant variability detected within the <span class="hlt">LAT</span> observation. This <span class="hlt">flux</span> is comparable withmore » the previous EGRET upper limit (<2.18 × 10 –8 photons cm –2 s –1, 2σ), thus there is no evidence for a significant MeV/GeV flare on decade timescales. Contemporaneous Chandra and Very Long Baseline Array data indicate low activity in the unresolved X-ray and radio core relative to previous observations, suggesting M87 is in a quiescent overall level over the first year of Fermi-<span class="hlt">LAT</span> observations. The <span class="hlt">LAT</span> γ-ray spectrum is modeled as synchrotron self-Compton (SSC) emission from the <span class="hlt">electron</span> population producing the radio-to-X-ray emission in the core. The resultant SSC spectrum extrapolates smoothly from the <span class="hlt">LAT</span> band to the historical-minimum TeV emission. Lastly, alternative models for the core and possible contributions from the kiloparsec-scale jet in M87 are considered, and cannot be excluded.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3534042','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3534042"><span><span class="hlt">LAT</span> Region Factors Mediating Differential Neuronal Tropism of HSV-1 and HSV-2 Do Not Act in Trans</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Bertke, Andrea S.; Apakupakul, Kathleen; Ma, AyeAye; Imai, Yumi; Gussow, Anne M.; Wang, Kening; Cohen, Jeffrey I.; Bloom, David C.; Margolis, Todd P.</p> <p>2012-01-01</p> <p>After HSV infection, some trigeminal ganglion neurons support productive cycle gene expression, while in other neurons the virus establishes a latent infection. We previously demonstrated that HSV-1 and HSV-2 preferentially establish latent infection in A5+ and KH10+ sensory neurons, respectively, and that exchanging the latency-associated transcript (<span class="hlt">LAT</span>) between HSV-1 and HSV-2 also exchanges the neuronal preference. Since many viral genes besides the <span class="hlt">LAT</span> are functionally interchangeable between HSV-1 and HSV-2, we co-infected HSV-1 and HSV-2, both in vivo and in vitro, to determine if trans-acting viral factors regulate whether HSV infection follows a productive or latent pattern of gene expression in sensory neurons. The pattern of HSV-1 and HSV-2 latent infection in trigeminal neurons was no different following co-infection than with either virus alone, consistent with the hypothesis that a trans-acting viral factor is not responsible for the different patterns of latent infection of HSV-1 and HSV-2 in A5+ and KH10+ neurons. Since exchanging the <span class="hlt">LAT</span> regions between the viruses also exchanges neuronal preferences, we infected transgenic mice that constitutively express 2.8 kb of the <span class="hlt">LAT</span> region with the heterologous viral serotype. Endogenous expression of <span class="hlt">LAT</span> did not alter the pattern of latent infection after inoculation with the heterologous serotype virus, demonstrating that the <span class="hlt">LAT</span> region does not act in trans to direct preferential establishment of latency of HSV-1 and HSV-2. Using HSV1-RFP and HSV2-GFP in adult trigeminal ganglion neurons in vitro, we determined that HSV-1 and HSV-2 do not exert trans-acting effects during acute infection to regulate neuron specificity. Although some neurons were productively infected with both HSV-1 and HSV-2, no A5+ or KH10+ neurons were productively infected with both viruses. Thus, trans-acting viral factors do not regulate preferential permissiveness of A5+ and KH10+ neurons for productive HSV infection and</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/23300908','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/23300908"><span><span class="hlt">LAT</span> region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bertke, Andrea S; Apakupakul, Kathleen; Ma, AyeAye; Imai, Yumi; Gussow, Anne M; Wang, Kening; Cohen, Jeffrey I; Bloom, David C; Margolis, Todd P</p> <p>2012-01-01</p> <p>After HSV infection, some trigeminal ganglion neurons support productive cycle gene expression, while in other neurons the virus establishes a latent infection. We previously demonstrated that HSV-1 and HSV-2 preferentially establish latent infection in A5+ and KH10+ sensory neurons, respectively, and that exchanging the latency-associated transcript (<span class="hlt">LAT</span>) between HSV-1 and HSV-2 also exchanges the neuronal preference. Since many viral genes besides the <span class="hlt">LAT</span> are functionally interchangeable between HSV-1 and HSV-2, we co-infected HSV-1 and HSV-2, both in vivo and in vitro, to determine if trans-acting viral factors regulate whether HSV infection follows a productive or latent pattern of gene expression in sensory neurons. The pattern of HSV-1 and HSV-2 latent infection in trigeminal neurons was no different following co-infection than with either virus alone, consistent with the hypothesis that a trans-acting viral factor is not responsible for the different patterns of latent infection of HSV-1 and HSV-2 in A5+ and KH10+ neurons. Since exchanging the <span class="hlt">LAT</span> regions between the viruses also exchanges neuronal preferences, we infected transgenic mice that constitutively express 2.8 kb of the <span class="hlt">LAT</span> region with the heterologous viral serotype. Endogenous expression of <span class="hlt">LAT</span> did not alter the pattern of latent infection after inoculation with the heterologous serotype virus, demonstrating that the <span class="hlt">LAT</span> region does not act in trans to direct preferential establishment of latency of HSV-1 and HSV-2. Using HSV1-RFP and HSV2-GFP in adult trigeminal ganglion neurons in vitro, we determined that HSV-1 and HSV-2 do not exert trans-acting effects during acute infection to regulate neuron specificity. Although some neurons were productively infected with both HSV-1 and HSV-2, no A5+ or KH10+ neurons were productively infected with both viruses. Thus, trans-acting viral factors do not regulate preferential permissiveness of A5+ and KH10+ neurons for productive HSV infection and</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/15180924','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/15180924"><span>The dopamine precursor L-dihydroxyphenylalanine is transported by the amino acid transporters rBAT and <span class="hlt">LAT</span>2 in renal cortex.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Quiñones, Henry; Collazo, Roberto; Moe, Orson W</p> <p>2004-07-01</p> <p>The intrarenal autocrine-paracrine dopamine (DA) system is critical for Na(+) homeostasis. l-Dihydroxyphenylalanine (l-DOPA) uptake from the glomerular filtrate and plasma provides the substrate for DA generation by the renal proximal tubule. The transporter(s) responsible for proximal tubule l-DOPA uptake has not been characterized. Renal cortical poly-A(+) RNA injected into Xenopus laevis oocytes induced l-DOPA uptake in a time- and dose-dependent fashion with biphasic K(m)s in the millimolar and micromolar range and independent of inward Na(+), K(+), or H(+) gradients, suggesting the presence of low- and high-affinity l-DOPA carriers. Complementary RNA from two amino acid transporters yielded l-DOPA uptake significantly above water-injected controls the rBAT/b(0,+)AT dimer (rBAT) and the <span class="hlt">LAT</span>2/4F2 dimer (<span class="hlt">LAT</span>2). In contradistinction to renal cortical poly-A(+), l-DOPA kinetics of rBAT and <span class="hlt">LAT</span>2 showed classic Michaelis-Menton kinetics with K(m)s in the micromolar and millimolar range, respectively. Sequence-specific antisense oligonucleotides to rBAT or <span class="hlt">LAT</span>2 (AS) caused inhibition of rBAT and <span class="hlt">LAT</span>2 cRNA-induced l-DOPA transport and cortical poly-A(+)-induced arginine and phenylalanine transport. However, the same ASs only partially blocked poly-A(+)-induced l-DOPA transport. In cultured kidney cells, silencing inhibitory RNA (siRNA) to rBAT significantly inhibited l-DOPA uptake. We conclude that rBAT and <span class="hlt">LAT</span>2 can mediate apical and basolateral l-DOPA uptake into the proximal tubule, respectively. Additional l-DOPA transport mechanisms exist in the renal cortex that remain to be identified.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015A%26A...584A..20W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015A%26A...584A..20W"><span>Gamma-ray activity of Seyfert galaxies and constraints on hot accretion flows</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Wojaczyński, Rafał; Niedźwiecki, Andrzej; Xie, Fu-Guo; Szanecki, Michał</p> <p>2015-12-01</p> <p>Aims: We check how the Fermi/<span class="hlt">LAT</span> data constrain the physics of hot accretion flows that are most likely present in low-luminosity AGNs. Methods: Using a precise model of emission from hot flows, we studied the flow γ-ray emission resulting from proton-proton interactions. We explored the dependence of the γ-ray luminosity on the accretion rate, the black hole spin, the magnetic field strength, the <span class="hlt">electron</span> heating efficiency, and the particle distribution. Then, we compared the hadronic γ-ray luminosities predicted by the model for several nearby Seyfert 1 galaxies with the results of our analysis of 6.4 years of Fermi/<span class="hlt">LAT</span> observations of these AGNs. Results: In agreement with previous studies, we find a significant γ-ray detection in NGC 6814. We were only able to derive upper limits for the remaining objects, although we report marginally significant (~3σ) signals at the positions of NGC 4151 and NGC 4258. The derived upper limits for the <span class="hlt">flux</span> above 1 GeV allow us to constrain the proton acceleration efficiency in flows with heating of <span class="hlt">electrons</span> dominated by Coulomb interactions, which case is favored by the X-ray spectral properties. In these flows, at most ~10% of the accretion power can be used for a relativistic acceleration of protons. Upper limits for the <span class="hlt">flux</span> below 1 GeV can constrain the magnetic field strength and black hole spin value; we find these constraints for NGC 7213 and NGC 4151. We also note that the spectral component above ~4 GeV previously found in the Fermi/<span class="hlt">LAT</span> data of Centaurus A may be due to hadronic emission from a flow within the above constraint. We rule out this origin of the γ-ray emission for NGC 6814. For models with a strong magnetohydrodynamic heating of <span class="hlt">electrons</span>, the hadronic γ-ray <span class="hlt">fluxes</span> are below the Fermi/<span class="hlt">LAT</span> sensitivity even for the closest AGNs. In these models, nonthermal Compton radiation may dominate in the γ-ray range if <span class="hlt">electrons</span> are efficiently accelerated and the acceleration index is hard; for the index </p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014AAS...22325601T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014AAS...22325601T"><span>The Third Fermi <span class="hlt">LAT</span> Catalog of High-Energy Gamma-ray Sources</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Thompson, David J.; Ballet, J.; Burnett, T.; Fermi Large Area Telescope Collaboration</p> <p>2014-01-01</p> <p>The Fermi Gamma-ray Space Telescope Large Area Telescope (<span class="hlt">LAT</span>) has been gathering science data since August 2008, surveying the full sky every three hours. The second source catalog (2FGL, Nolan et al 2012, ApJS 199, 31) was based on 2 years of data. We are preparing a third source catalog (3FGL) based on 4 years of reprocessed data. The reprocessing introduced a more accurate description of the instrument, which resulted in a narrower point spread function. Both the localization and the detection threshold for hard-spectrum sources have been improved. The new catalog also relies on a refined model of Galactic diffuse emission, particularly important for low-latitude soft-spectrum sources. The process for associating <span class="hlt">LAT</span> sources with those at other wavelengths has also improved, thanks to dedicated multiwavelength follow-up, new surveys and better ways to extract sources likely to be gamma-ray counterparts. We describe the construction of this new catalog, its characteristics, and its remaining limitations.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014APS..APR.L1022B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014APS..APR.L1022B"><span>The Third Fermi-<span class="hlt">LAT</span> Catalog of High-Energy Gamma-ray Sources</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Burnett, Toby</p> <p>2014-03-01</p> <p>The Fermi Gamma-ray Space Telescope Large Area Telescope (<span class="hlt">LAT</span>) has been gathering science data since August 2008, surveying the full sky every three hours. The second source catalog (2FGL, Nolan et al. 2012, ApJS 199, 31) was based on 2 years of data. We are preparing a third source catalog (3FGL) based on 4 years of reprocessed data. The reprocessing introduced a more accurate description of the instrument, which resulted in a narrower point spread function. Both the localization and the detection threshold for hard-spectrum sources have been improved. The new catalog also relies on a refined model of Galactic diffuse emission, particularly important for low-latitude soft-spectrum sources. The process for associating <span class="hlt">LAT</span> sources with those at other wavelengths has also improved, thanks to dedicated multiwavelength follow-up, new surveys and better ways to extract sources likely to be gamma-ray counterparts. We describe the construction of this new catalog, its characteristics, and its remaining limitations.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20110010995','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20110010995"><span>High Energy Cosmic <span class="hlt">Electrons</span>: Messengers from Nearby Cosmic Ray Sources or Dark Matter?</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Moiseev, Alexander</p> <p>2011-01-01</p> <p>This slide presentation reviews the recent discoveries by the Large Area Telescope (<span class="hlt">LAT</span>) and the Gamma-ray Burst Monitor (GBM) on board the Fermi Gamma-Ray Telescope in reference to high energy cosmic <span class="hlt">electrons</span>, and whether their source is cosmic rays or dark matter. Specific interest is devoted to Cosmic Ray <span class="hlt">electrons</span> anisotropy,</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015yCat..17710057A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015yCat..17710057A"><span>VizieR Online Data Catalog: Fermi-<span class="hlt">LAT</span> flaring gamma-ray sources from FAVA (Ackermann+, 2013)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ackermann, M.; Ajello, M.; Albert, A.; Allafort, A.; Antolini, E.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Blandford, R. D.; Bloom, E. D.; Bonamente, E.; Bottacini, E.; Bouvier, A.; Brandt, T. J.; Bregeon, J.; Brigida, M.; Bruel, P.; Buehler, R.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caraveo, P. A.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Chekhtman, A.; Cheung, C. C.; Chiang, J.; Chiaro, G.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Conrad, J.; Cutini, S.; Dalton, M.; D'Ammando, F.; de Angelis, A.; de Palma, F.; Dermer, C. D.; di Venere, L.; Drell, P. S.; Drlica-Wagner, A.; Favuzzi, C.; Fegan, S. J.; Ferrara, E. C.; Focke, W. B.; Franckowiak, A.; Fukazawa, Y.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Germani, S.; Giglietto, N.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Grenier, I. A.; Grondin, M.-H.; Grove, J. E.; Guiriec, S.; Hadasch, D.; Hanabata, Y.; Harding, A. K.; Hayashida, M.; Hays, E.; Hewitt, J.; Hill, A. B.; Horan, D.; Hou, X.; Hughes, R. E.; Inoue, Y.; Jackson, M. S.; Jogler, T.; Johannesson, G.; Johnson, W. N.; Kamae, T.; Kataoka, J.; Kawano, T.; Knodlseder, J.; Kuss, M.; Lande, J.; Larsson, S.; Latronico, L.; Lemoine-Goumard, M.; Longo, F.; Loparco, F.; Lott, B.; Lovellette, M. N.; Lubrano, P.; Mayer, M.; Mazziotta, M. N.; McEnery, J. E.; Michelson, P. F.; Mitthumsiri, W.; Mizuno, T.; Monte, C.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nemmen, R.; Nuss, E.; Ohsugi, T.; Okumura, A.; Omodei, N.; Orienti, M.; Orlando, E.; Ormes, J. F.; Paneque, D.; Panetta, J. H.; Perkins, J. S.; Pesce-Rollins, M.; Piron, F.; Pivato, G.; Porter, T. A.; Raino, S.; Rando, R.; Razzano, M.; Reimer, A.; Reimer, O.; Romoli, C.; Roth, M.; Sanchez-Conde, M.; Scargle, J. D.; Schulz, A.; Sgro, C.; Siskind, E. J.; Spandre, G.; Spinelli, P.; Suson, D. J.; Takahashi, H.; Takeuchi, Y.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Tibaldo, L.; Tinivella, M.; Torres, D. F.; Tosti, G.; Troja, E.; Tronconi, V.; Usher, T. L.; Vandenbroucke, J.; Vasileiou, V.; Vianello, G.; Vitale, V.; Winer, B. L.; Wood, K. S.; Wood, M.; Yang, Z.</p> <p>2015-01-01</p> <p>We applied FAVA (Fermi All-sky Variability Analysis) to the first 47 months of Fermi/<span class="hlt">LAT</span> observations (2008 August 4 to 2012 July 16 UTC), in weekly time intervals. The total number of weeks is 206. We considered two ranges of gamma-ray energy, E>100MeV and E>800MeV, to increase the sensitivity for spectrally soft and hard flares, respectively. We generate measured and expected count maps with a resolution of 0.25deg2 per pixel. We found <span class="hlt">LAT</span> counterparts for 192 of the 215 FAVA sources. Most of the associated sources, 177, are AGNs. (2 data files).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20020001784','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20020001784"><span>A 7.5-Year Dataset of SSM/I-Derived Surface Turbulent <span class="hlt">Fluxes</span> Over Global Oceans</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Chou, Shu-Hsien; Shie, Chung-Lin; Atlas, Robert M.; Adizzone, Joe; Nelkin, Eric; Starr, David OC. (Technical Monitor)</p> <p>2001-01-01</p> <p>The global air-sea turbulent <span class="hlt">fluxes</span> are needed for driving ocean models and validating coupled ocean-atmosphere global models. A method was developed to retrieve surface air humidity from the radiances measured by the Special Sensor Microwave/Imager (SSM/I) Using both SSM/I-retrieved surface wind and air humidity, they computed daily turbulent <span class="hlt">fluxes</span> over global oceans with a stability-dependent bulk scheme. Based on this method, we have produced Version 1 of Goddard Satellite-Based Surface Turbulent <span class="hlt">Fluxes</span> (GSSTF) dataset from the SSM/I data and other data. It provides daily- and monthly-mean surface turbulent <span class="hlt">fluxes</span> and some relevant parameters over global oceans for individual F8, F10, and F11 satellites covering the period July 1987-December 1994. It also provides 1988-94 annual- and monthly-mean climatologies of the same variables, using only F8 and F1 1 satellite data. It has a spatial resolution of 2.0 degrees x 2.5 degrees <span class="hlt">lat</span>-long and is archived at the NASA/GSFC DAAC. The purpose of this paper is to present an updated assessment of the GSSTF 1.0 dataset.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4618093','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4618093"><span>Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency associated transcript (<span class="hlt">LAT</span>) mutant using the in vivo mouse UV-B model of induced reactivation</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>BenMohamed, Lbachir; Osorio, Nelson; Srivastava, Ruchi; Khan, Arif A.; Simpson, Jennifer L.; Wechsler, Steven L.</p> <p>2015-01-01</p> <p>Blinding ocular herpetic disease in humans is due to herpes simplex virus type 1 (HSV-1) reactivations from latency, rather than to primary acute infection. The cellular and molecular mechanisms that control the HSV-1 latency-reactivation cycle remain to be fully elucidated. The aim of this study was to determine if reactivation of the HSV-1 latency associated transcript (<span class="hlt">LAT</span>) deletion mutant (d<span class="hlt">LAT</span>2903) was impaired in this model, as it is in the rabbit model of induced and spontaneous reactivation and in the explant TG induced reactivation model in mice. The eyes of mice latently infected with wild type HSV-1 strain McKrae (<span class="hlt">LAT</span>(+) virus) or d<span class="hlt">LAT</span>2903 (<span class="hlt">LAT</span>(−) virus) were irradiated with UV-B and reactivation was determined. We found that compared to <span class="hlt">LAT</span>(−) virus, <span class="hlt">LAT</span>(+) virus reactivated at a higher rate as determined by shedding of virus in tears on days 3 to 7 after UV-B treatment. Thus, the UV-B induced reactivation model of HSV-1 appears to be a useful small animal model for studying the mechanisms involved in how <span class="hlt">LAT</span> enhances the HSV-1 reactivation phenotype. The utility of the model for investigating the immune evasion mechanisms regulating the HSV-1 latency/reactivation cycle and for testing the protective efficacy of candidate therapeutic vaccines and drugs are discussed. PMID:26002839</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active"><span>16</span></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_16 --> <div id="page_17" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="321"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29099056','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29099056"><span>Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y⁺<span class="hlt">LAT</span>2 Carrier-Mediated Loss.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Milewski, Krzysztof; Bogacińska-Karaś, Małgorzata; Fręśko, Inez; Hilgier, Wojciech; Jaźwiec, Radosław; Albrecht, Jan; Zielińska, Magdalena</p> <p>2017-11-02</p> <p>Previously we had shown that ammonia stimulates nitric oxide (NO) synthesis in astrocytes by increasing the uptake of the precursor amino acid, arginine via the heteromeric arginine/glutamine transporter y⁺<span class="hlt">LAT</span>2. Ammonia also increases the concentration in the brain of the endogenous inhibitor of nitric oxide synthases (NOS), asymmetric dimethylarginine (ADMA), but distribution of ADMA surplus between the intraastrocytic and extracellular compartments of the brain has not been studied. Here we tested the hypothesis that ammonia modulates the distribution of ADMA and its analog symmetric dimethylarginine (SDMA) between the two compartments of the brain by competition with arginine for the y⁺<span class="hlt">LAT</span>2 transporter. In extension of the hypothesis we analyzed the ADMA/Arg interaction in endothelial cells forming the blood-brain barrier. We measured by high-performance liquid chromatography (HPLC) and mass spectrometry (MS) technique the concentration of arginine, ADMA and SDMA in cultured cortical astrocytes and in a rat brain endothelial cell line (RBE-4) treated with ammonia and the effect of silencing the expression of a gene coding y⁺<span class="hlt">LAT</span>2. We also tested the expression of ADMA metabolism enzymes: protein arginine methyltransferase (PRMT) and dimethylarginine dimethyl aminohydrolase (DDAH) and arginine uptake to astrocytes. Treatment for 48 h with 5 mM ammonia led to an almost 50% reduction of ADMA and SDMA concentration in both cell types, and the effect in astrocytes was substantially attenuated by silencing of the Slc7a6 gene. Moreover, the y⁺<span class="hlt">LAT</span>2-dependent component of ammonia-evoked arginine uptake in astrocytes was reduced in the presence of ADMA in the medium. Our results suggest that increased ADMA efflux mediated by upregulated y⁺<span class="hlt">LAT</span>2 may be a mechanism by which ammonia interferes with intra-astrocytic (and possibly intra-endothelial cell) ADMA content and subsequently, NO synthesis in both cell types.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012cosp...39.1309M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012cosp...39.1309M"><span>Progress towards a measurement of the UHE cosmic ray <span class="hlt">electron</span> <span class="hlt">flux</span> using the CREST Instrument</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Musser, Jim; Wakely, Scott; Coutu, Stephane; Geske, Matthew; Nutter, Scott; Tarle, Gregory; Park, Nahee; Schubnell, Michael; Gennaro, Joseph; Muller, Dietrich</p> <p>2012-07-01</p> <p><span class="hlt">Electrons</span> of energy beyond about 3 TeV have never been detected in the <span class="hlt">flux</span> of cosmic rays at Earth despite strong evidence of their presence in a number of supernova remnants (e.g., SN 1006). The detection of high energy <span class="hlt">electrons</span> at Earth would be extremely significant, yielding information about the spatial distribution of nearby cosmic ray sources. With the Cosmic Ray <span class="hlt">Electron</span> Synchrotron Telescope (CREST), our collaboration has adopted a novel approach to the detection of <span class="hlt">electrons</span> of energies between 2 and 50 TeV which results in a substantial increase in the acceptance and sensitivity of the apparatus relative to its physics size. The first LDB flight of the CREST detector took place in January 2012, with a float duration of approximately 10 days. In this paper we describe the flight performance of the instrument, and progress in the analysis of the data obtained in this flight.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/5021315-tectonic-significance-magnetic-gravity-data-across-northern-california-lat-degree-lat-degree','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/5021315-tectonic-significance-magnetic-gravity-data-across-northern-california-lat-degree-lat-degree"><span>Tectonic significance of magnetic and gravity data across northern California (<span class="hlt">lat</span>. 39[degree]N. to <span class="hlt">lat</span>. 41[degree]N. )</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Griscom, A.; Roberts, C.W.; Halvorson, P.F.</p> <p>1993-04-01</p> <p>Aeromagnetic and isostatic residual gravity maps of an east-west transect across northern California show important tectonic features. A linear magnetic anomaly and west-sloping gradient extends over 300 km along the Franciscan-Great Valley contact (FGC) and across the Klamath Mountains province (KM) north to <span class="hlt">lat</span>. 40[degree]45'N. The anomaly source lies at depths of 5--10 km beneath the KM and the FGC, and implies that the Franciscan complex of the Coast Ranges is thrust (and wedged) at least 80 km eastward beneath the KM to approximately long. 122[degree]40 minutes W. Calculations on a circular gravity low of [minus]50 mGal centered at themore » circular Bald Rock pluton (diameter about 15 km) in the Sierran foothills indicate a pluton thickness of about 15 km. The nearby Cascade and Merrimac plutons are located on the gradients of this gravity anomaly, have a relatively minor effect on it, and thus are interpreted to be thick (up to 5 km) laccolithic sills that emanate from the Bald Rock pluton, thinning away from it to a feather edge. Model studies indicate that the northeast contact of the Feather River periodotite body (FRPB) north of <span class="hlt">lat</span>. 39[degree]40 minutes N. generally dips steeply northeast or vertical. The same contact south of this latitude dips east at angles of about 45[degree] to depths of at least 10 km. Magnetic patterns extending from the northern Sierra across the Cascades to the Klamath Mountains suggest that the FRPB may correlate with the Trinity ophiolite.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19574346','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19574346"><span>Detection of 16 gamma-ray pulsars through blind frequency searches using the Fermi <span class="hlt">LAT</span>.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Abdo, A A; Ackermann, M; Ajello, M; Anderson, B; Atwood, W B; Axelsson, M; Baldini, L; Ballet, J; Barbiellini, G; Baring, M G; Bastieri, D; Baughman, B M; Bechtol, K; Bellazzini, R; Berenji, B; Bignami, G F; Blandford, R D; Bloom, E D; Bonamente, E; Borgland, A W; Bregeon, J; Brez, A; Brigida, M; Bruel, P; Burnett, T H; Caliandro, G A; Cameron, R A; Caraveo, P A; Casandjian, J M; Cecchi, C; Celik, O; Chekhtman, A; Cheung, C C; Chiang, J; Ciprini, S; Claus, R; Cohen-Tanugi, J; Conrad, J; Cutini, S; Dermer, C D; de Angelis, A; de Luca, A; de Palma, F; Digel, S W; Dormody, M; do Couto e Silva, E; Drell, P S; Dubois, R; Dumora, D; Farnier, C; Favuzzi, C; Fegan, S J; Fukazawa, Y; Funk, S; Fusco, P; Gargano, F; Gasparrini, D; Gehrels, N; Germani, S; Giebels, B; Giglietto, N; Giommi, P; Giordano, F; Glanzman, T; Godfrey, G; Grenier, I A; Grondin, M-H; Grove, J E; Guillemot, L; Guiriec, S; Gwon, C; Hanabata, Y; Harding, A K; Hayashida, M; Hays, E; Hughes, R E; Jóhannesson, G; Johnson, R P; Johnson, T J; Johnson, W N; Kamae, T; Katagiri, H; Kataoka, J; Kawai, N; Kerr, M; Knödlseder, J; Kocian, M L; Kuss, M; Lande, J; Latronico, L; Lemoine-Goumard, M; Longo, F; Loparco, F; Lott, B; Lovellette, M N; Lubrano, P; Madejski, G M; Makeev, A; Marelli, M; Mazziotta, M N; McConville, W; McEnery, J E; Meurer, C; Michelson, P F; Mitthumsiri, W; Mizuno, T; Monte, C; Monzani, M E; Morselli, A; Moskalenko, I V; Murgia, S; Nolan, P L; Norris, J P; Nuss, E; Ohsugi, T; Omodei, N; Orlando, E; Ormes, J F; Paneque, D; Parent, D; Pelassa, V; Pepe, M; Pesce-Rollins, M; Pierbattista, M; Piron, F; Porter, T A; Primack, J R; Rainò, S; Rando, R; Ray, P S; Razzano, M; Rea, N; Reimer, A; Reimer, O; Reposeur, T; Ritz, S; Rochester, L S; Rodriguez, A Y; Romani, R W; Ryde, F; Sadrozinski, H F-W; Sanchez, D; Sander, A; Saz Parkinson, P M; Scargle, J D; Sgrò, C; Siskind, E J; Smith, D A; Smith, P D; Spandre, G; Spinelli, P; Starck, J-L; Strickman, M S; Suson, D J; Tajima, H; Takahashi, H; Takahashi, T; Tanaka, T; Thayer, J G; Thompson, D J; Tibaldo, L; Tibolla, O; Torres, D F; Tosti, G; Tramacere, A; Uchiyama, Y; Usher, T L; Van Etten, A; Vasileiou, V; Vilchez, N; Vitale, V; Waite, A P; Wang, P; Watters, K; Winer, B L; Wolff, M T; Wood, K S; Ylinen, T; Ziegler, M</p> <p>2009-08-14</p> <p>Pulsars are rapidly rotating, highly magnetized neutron stars emitting radiation across the electromagnetic spectrum. Although there are more than 1800 known radio pulsars, until recently only seven were observed to pulse in gamma rays, and these were all discovered at other wavelengths. The Fermi Large Area Telescope (<span class="hlt">LAT</span>) makes it possible to pinpoint neutron stars through their gamma-ray pulsations. We report the detection of 16 gamma-ray pulsars in blind frequency searches using the <span class="hlt">LAT</span>. Most of these pulsars are coincident with previously unidentified gamma-ray sources, and many are associated with supernova remnants. Direct detection of gamma-ray pulsars enables studies of emission mechanisms, population statistics, and the energetics of pulsar wind nebulae and supernova remnants.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28538176','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28538176"><span>Tonic <span class="hlt">LAT</span>-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Myers, Darienne R; Lau, Tannia; Markegard, Evan; Lim, Hyung W; Kasler, Herbert; Zhu, Minghua; Barczak, Andrea; Huizar, John P; Zikherman, Julie; Erle, David J; Zhang, Weiguo; Verdin, Eric; Roose, Jeroen P</p> <p>2017-05-23</p> <p>CD4 + T cells differentiate into T helper cell subsets in feedforward manners with synergistic signals from the T cell receptor (TCR), cytokines, and lineage-specific transcription factors. Naive CD4 + T cells avoid spontaneous engagement of feedforward mechanisms but retain a prepared state. T cells lacking the adaptor molecule <span class="hlt">LAT</span> demonstrate impaired TCR-induced signals yet cause a spontaneous lymphoproliferative T helper 2 (T H 2) cell syndrome in mice. Thus, <span class="hlt">LAT</span> constitutes an unexplained maintenance cue. Here, we demonstrate that tonic signals through <span class="hlt">LAT</span> constitutively export the repressor HDAC7 from the nucleus of CD4 + T cells. Without such tonic signals, HDAC7 target genes Nur77 and Irf4 are repressed. We reveal that Nur77 suppresses CD4 + T cell proliferation and uncover a suppressive role for Irf4 in T H 2 polarization; halving Irf4 gene-dosage leads to increases in GATA3 + and IL-4 + cells. Our studies reveal that naive CD4 + T cells are dynamically tuned by tonic <span class="hlt">LAT</span>-HDAC7 signals. Published by Elsevier Inc.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017yCat..18100085C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017yCat..18100085C"><span>VizieR Online Data Catalog: Observation of first Fermi-<span class="hlt">LAT</span> sources at Parkes (Camilo+, 2015)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Camilo, F.; Kerr, M.; Ray, P. S.; Ransom, S. M.; Sarkissian, J.; Cromartie, H. T.; Johnston, S.; Reynolds, J. E.; Wolff, M. T.; Freire, P. C. C.; Bhattacharyya, B.; Ferrara, E. C.; Keith, M.; Michelson, P. F.; Parkinson, P. M. S.; Wood, K. S.</p> <p>2017-10-01</p> <p>Keith et al. (2011MNRAS.414.1292K) used a digital filterbank at Parkes to search 11 unidentified sources from the first Fermi-<span class="hlt">LAT</span> catalog (1FGL; Abdo et al. 2010, J/ApJS/188/405). Two MSPs and one slow pulsar were discovered in single observations of each target at a central frequency of 1.4 GHz. Subsequently, one of these MSPs was found to be associated with the corresponding <span class="hlt">LAT</span> source. At nearly the same time, in late 2009, we used an analog filterbank at Parkes to search 14 unidentified 1FGL sources (Kerr et al. 2012ApJ...748L...2K). The single observations of these targets resulted in the detection of six MSPs, five of them discoveries. However, confirmation of some of these MSPs was not easy: the search observations lasted for 1-2 hr each, but some of the pulsars were not detected in equivalent initial confirmation attempts, owing to the effects of interstellar scintillation. These and other selection effects (see Section 2.2 for details) led us to search some promising unidentified <span class="hlt">LAT</span> sources repeatedly. (1 data file).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22664038-topology-canonical-flux-tubes-flared-jet-geometry','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22664038-topology-canonical-flux-tubes-flared-jet-geometry"><span>THE TOPOLOGY OF CANONICAL <span class="hlt">FLUX</span> TUBES IN FLARED JET GEOMETRY</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Lavine, Eric Sander; You, Setthivoine, E-mail: Slavine2@uw.edu, E-mail: syou@aa.washington.edu</p> <p>2017-01-20</p> <p>Magnetized plasma jets are generally modeled as magnetic <span class="hlt">flux</span> tubes filled with flowing plasma governed by magnetohydrodynamics (MHD). We outline here a more fundamental approach based on <span class="hlt">flux</span> tubes of canonical vorticity, where canonical vorticity is defined as the circulation of the species’ canonical momentum. This approach extends the concept of magnetic <span class="hlt">flux</span> tube evolution to include the effects of finite particle momentum and enables visualization of the topology of plasma jets in regimes beyond MHD. A flared, current-carrying magnetic <span class="hlt">flux</span> tube in an ion-<span class="hlt">electron</span> plasma with finite ion momentum is thus equivalent to either a pair of <span class="hlt">electron</span> andmore » ion flow <span class="hlt">flux</span> tubes, a pair of <span class="hlt">electron</span> and ion canonical momentum <span class="hlt">flux</span> tubes, or a pair of <span class="hlt">electron</span> and ion canonical vorticity <span class="hlt">flux</span> tubes. We examine the morphology of all these <span class="hlt">flux</span> tubes for increasing electrical currents, different radial current profiles, different <span class="hlt">electron</span> Mach numbers, and a fixed, flared, axisymmetric magnetic geometry. Calculations of gauge-invariant relative canonical helicities track the evolution of magnetic, cross, and kinetic helicities in the system, and show that ion flow fields can unwind to compensate for an increasing magnetic twist. The results demonstrate that including a species’ finite momentum can result in a very long collimated canonical vorticity <span class="hlt">flux</span> tube even if the magnetic <span class="hlt">flux</span> tube is flared. With finite momentum, particle density gradients must be normal to canonical vorticities, not to magnetic fields, so observations of collimated astrophysical jets could be images of canonical vorticity <span class="hlt">flux</span> tubes instead of magnetic <span class="hlt">flux</span> tubes.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19850049084&hterms=max+planck&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Dmax%2Bplanck','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19850049084&hterms=max+planck&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Dmax%2Bplanck"><span>Energetic particle characteristics of magnetotail <span class="hlt">flux</span> ropes</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Scholer, M.; Klecker, B.; Hovestadt, D.; Gloeckler, G.; Ipavich, F. M.; Galvin, A. B.</p> <p>1985-01-01</p> <p>During the recent ISEE-3 Geotail Mission three events have been identified from the magnetometer data which are consistent with a spacecraft crossing of a magnetotail <span class="hlt">flux</span> rope. Energetic <span class="hlt">electron</span> and proton observations obtained by the Max-Planck-Institut/University of Maryland sensor system during two of the possible <span class="hlt">flux</span> rope events are presented. During one event remote sensing of the <span class="hlt">flux</span> rope with energetic protons reveals that the <span class="hlt">flux</span> rope is crossed by the spacecraft from south to north. This allows determination of the bandedness of the magnetic field twist and of the <span class="hlt">flux</span> rope velocity relative to the spacecraft. A minimal <span class="hlt">flux</span> rope radius of 3 earth radii is derived. Energetic proton intensity is highest just inside of the <span class="hlt">flux</span> rope and decreases towards the core. Energetic <span class="hlt">electrons</span> are streaming tailward near the outer boundary, indicating openness of the field lines, and are isotropic through the inner part of the <span class="hlt">flux</span> rope.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AGUOSPO23A..03S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AGUOSPO23A..03S"><span>Heat and salt budgets over the Gulf Stream North Wall during <span class="hlt">Lat</span>Mix survey in winter 2012.</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Sanchez-Rios, A.; Shearman, R. K.; D'Asaro, E. A.; Lee, C.; Gula, J.; Klymak, J. M.</p> <p>2016-02-01</p> <p>As part of the ONR-sponsored <span class="hlt">Lat</span>Mix Experiment, ship-based and glider-based observations following a Lagrangian float are used to examine the evolution of temperature, salinity and density along the Gulf Stream north wall in wintertime. Satellite observations during the survey and the in-situ measurements showed the presence of submesoscale (<10 km) features along the front. Models have successfully reproduced similar features, but observations are lacking, particularly at the small scales needed to understand their role in the transport of heat and salt across the front and out of the mixed layer. Calculating the trend in time at each depth and cross-front location we found an increase of heat and salinity in regions where the strongest cross-front gradients of velocity were observed at the mixed layer and around 150m depth, these changes are density compensated and suggest isopycnal mixing and a connection between the mixed layer and subsurface layers. The large Rossby number (Ro>1) calculated for this regions corroborates the possibility of submesoscale dynamics. Using a heat and salinity budget, we show that surface forcing, entrainment from below and advection by the mean flow velocities are not sufficient to explain the observed rate of change of heat and salinity in the mixed layer. Although confidence estimates prevent an accurate <span class="hlt">flux</span> divergence calculation, Reynold <span class="hlt">flux</span> estimates are consistent with a cross-frontal exchange that can reproduce the observed temporal trends.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/21192402-electron-impact-emission-spectroscopy-flux-sensor-monitoring-deposition-rate-high-background-gas-pressure-improved-accuracy','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/21192402-electron-impact-emission-spectroscopy-flux-sensor-monitoring-deposition-rate-high-background-gas-pressure-improved-accuracy"><span>An <span class="hlt">electron</span> impact emission spectroscopy <span class="hlt">flux</span> sensor for monitoring deposition rate at high background gas pressure with improved accuracy</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Lu, C.; Blissett, C. D.; Diehl, G.</p> <p>2008-07-15</p> <p><span class="hlt">Electron</span> impact emission spectroscopy (EIES) has been proven to be a critical tool for film composition control during codeposition processes for the fabrication of multicomponent thin film materials including the high-efficiency copper-indium-gallium-diselenide photovoltaic cells. This technique is highly specific to atomic species because the emission spectrum of each element is unique, and the typical width of atomic emission lines is very narrow. Noninterfering emission lines can generally be allocated to different atomic species. However, the <span class="hlt">electron</span> impact emission spectra of many molecular species are often broadband in nature. When the optical emission from an EIES sensor is measured by usingmore » a wavelength selection device with a modest resolution, such as an optical filter or monochromator, the emissions from common residual gases may interfere with that from the vapor <span class="hlt">flux</span> and cause erroneous <span class="hlt">flux</span> measurement. The interference is most pronounced when measuring low <span class="hlt">flux</span> density with the presence of gases such as in reactive deposition processes. This problem is solved by using a novel EIES sensor that has two <span class="hlt">electron</span> impact excitation sources in separate compartments but with one common port for optical output. The vapor <span class="hlt">flux</span> is allowed to pass through one compartment only. Using a tristate excitation scheme and appropriate signal processing technique, the interfering signals from residual gases can be completely eliminated from the output signal of the EIES monitor for process control. Data obtained from Cu and Ga evaporations with the presence of common residual gases such as CO{sub 2} and H{sub 2}O are shown to demonstrate the improvement in sensor performance. The new EIES sensor is capable of eliminating the effect of interfering residual gases with pressure as high as in the upper 10{sup -5} Torr range.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/18464161','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/18464161"><span>Critical role of FcR gamma-chain, <span class="hlt">LAT</span>, PLCgamma2 and thrombin in arteriolar thrombus formation upon mild, laser-induced endothelial injury in vivo.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kalia, Neena; Auger, Jocelyn M; Atkinson, Ben; Watson, Steve P</p> <p>2008-05-01</p> <p>The role of collagen receptor complex GPVI-FcR gamma-chain, PLCgamma2 and <span class="hlt">LAT</span> in laser-induced thrombosis is unclear. Controversy surrounds whether collagen is exposed in this model or whether thrombosis is dependent on thrombin. This study hypothesized that collagen exposure plays a critical role in thrombus formation in this model, which was tested by investigating contributions of FcR gamma-chain, <span class="hlt">LAT</span>, PLCgamma2 and thrombin. Thrombi were monitored using intravital microscopy in anesthetized wild-type and FcR gamma-chain, <span class="hlt">LAT</span> and PLCgamma2 knockout mice. Hirudin (thrombin inhibitor) was administered to wild-type and FcR gamma-chain knockout mice. Significantly reduced thrombus formation was observed in FcR gamma-chain and PLCgamma2 knockouts with a greater decrease observed in <span class="hlt">LAT</span> knockouts. Dramatic reduction was observed in wild-types treated with hirudin, with abolished thrombus formation only observed in FcR gamma-chain knockouts treated with hirudin. GPVI-FcR gamma-chain, <span class="hlt">LAT</span> and PLCgamma2 are essential for thrombus generation and stability in this laser-induced model of injury. More importantly, a greater role for <span class="hlt">LAT</span> was identified, which may reflect a role for it downstream of a second matrix protein receptor. However, inhibition of platelet activation by matrix proteins and thrombin generation are both required to maximally prevent thrombus formation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1357445-detection-gamma-ray-pulsars-through-blind-frequency-searches-using-fermi-lat','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1357445-detection-gamma-ray-pulsars-through-blind-frequency-searches-using-fermi-lat"><span>Detection of 16 Gamma-Ray Pulsars Through Blind Frequency Searches Using the Fermi <span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Abdo, A. A.; Ackermann, M.; Ajello, M.; ...</p> <p>2009-07-02</p> <p>Pulsars are rapidly rotating, highly magnetized neutron stars emitting radiation across the electromagnetic spectrum. Although there are more than 1800 known radio pulsars, until recently only seven were observed to pulse in gamma rays, and these were all discovered at other wavelengths. The Fermi Large Area Telescope (<span class="hlt">LAT</span>) makes it possible to pinpoint neutron stars through their gamma-ray pulsations. In this paper, we report the detection of 16 gamma-ray pulsars in blind frequency searches using the <span class="hlt">LAT</span>. Most of these pulsars are coincident with previously unidentified gamma-ray sources, and many are associated with supernova remnants. Finally, direct detection of gamma-raymore » pulsars enables studies of emission mechanisms, population statistics, and the energetics of pulsar wind nebulae and supernova remnants.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22462006-mir-modulates-resistance-hr-hpv-positive-cervical-cancer-cells-radiation-through-targeting-lats1','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22462006-mir-modulates-resistance-hr-hpv-positive-cervical-cancer-cells-radiation-through-targeting-lats1"><span>miR-21 modulates resistance of HR-HPV positive cervical cancer cells to radiation through targeting <span class="hlt">LATS</span>1</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Liu, Shikai; Song, Lili, E-mail: commasll@163.com; Zhang, Liang</p> <p></p> <p>Although multiple miRNAs are found involved in radioresistance development in HR-HPV positive (+) cervical cancer, only limited studies explored the regulative mechanism of the miRNAs. miR-21 is one of the miRNAs significantly upregulated in HR-HPV (+) cervical cancer is also significantly associated with radioresistance. However, the detailed regulative network of miR-21 in radioresistance is still not clear. In this study, we confirmed that miR-21 overexpression was associated with higher level of radioresistance in HR-HPV (+) cervical cancer patients and thus decided to further explore its role. Findings of this study found miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervicalmore » cancer cells and decrease radiation induced G2/M block and increase S phase accumulation. By using dual luciferase assay, we verified a binding site between miR-21 and 3′-UTR of large tumor suppressor kinase 1 (<span class="hlt">LATS</span>1). Through direct binding, miR-21 can regulate <span class="hlt">LATS</span>1 expression in cervical cancer cells. <span class="hlt">LATS</span>1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment. These results suggested that miR-21-<span class="hlt">LATS</span>1 axis plays an important role in regulating radiosensitivity. - Highlights: • miR-21 is highly expressed in HR-HPV (+) radioresistant cervical cancer patients. • miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells. • miR-21 can decrease radiation induced G2/M block and increase S phase accumulation. • miR-21 modulates radiosensitivity cervical cancer cell by directly targeting <span class="hlt">LATS</span>1.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018MNRAS.475..942F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018MNRAS.475..942F"><span>An image-based search for pulsars among Fermi unassociated <span class="hlt">LAT</span> sources</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Frail, D. A.; Ray, P. S.; Mooley, K. P.; Hancock, P.; Burnett, T. H.; Jagannathan, P.; Ferrara, E. C.; Intema, H. T.; de Gasperin, F.; Demorest, P. B.; Stovall, K.; McKinnon, M. M.</p> <p>2018-03-01</p> <p>We describe an image-based method that uses two radio criteria, compactness, and spectral index, to identify promising pulsar candidates among Fermi Large Area Telescope (<span class="hlt">LAT</span>) unassociated sources. These criteria are applied to those radio sources from the Giant Metrewave Radio Telescope all-sky survey at 150 MHz (TGSS ADR1) found within the error ellipses of unassociated sources from the 3FGL catalogue and a preliminary source list based on 7 yr of <span class="hlt">LAT</span> data. After follow-up interferometric observations to identify extended or variable sources, a list of 16 compact, steep-spectrum candidates is generated. An ongoing search for pulsations in these candidates, in gamma rays and radio, has found 6 ms pulsars and one normal pulsar. A comparison of this method with existing selection criteria based on gamma-ray spectral and variability properties suggests that the pulsar discovery space using Fermi may be larger than previously thought. Radio imaging is a hitherto underutilized source selection method that can be used, as with other multiwavelength techniques, in the search for Fermi pulsars.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22277691-hunting-dark-matter-gamma-ray-lines-fermi-lat','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22277691-hunting-dark-matter-gamma-ray-lines-fermi-lat"><span>Hunting dark matter gamma-ray lines with the Fermi <span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Vertongen, Gilles; Weniger, Christoph, E-mail: gilles.vertongen@desy.de, E-mail: weniger@mppmu.mpg.de</p> <p>2011-05-01</p> <p>Monochromatic photons could be produced in the annihilation or decay of dark matter particles. At high energies, the search for such line features in the cosmic gamma-ray spectrum is essentially background free because plausible astrophysical processes are not expected to produce such a signal. The observation of a gamma-ray line would hence be a 'smoking-gun' signature for dark matter, making the search for such signals particularly attractive. Among the different dark matter models predicting gamma-ray lines, the local supersymmetric extension of the standard model with small R-parity violation and gravitino LSP is of particular interest because it provides a frameworkmore » where primordial nucleosynthesis, gravitino dark matter and thermal leptogenesis are naturally consistent. Using the two-years Fermi <span class="hlt">LAT</span> data, we present a dedicated search for gamma-ray lines coming from dark matter annihilation or decay in the Galactic halo. Taking into account the full detector response, and using a binned profile likelihood method, we search for significant line features in the energy spectrum of the diffuse <span class="hlt">flux</span> observed in different regions of the sky. No evidence for a line signal at the 5σ level is found for photon energies between 1 and 300 GeV, and conservative bounds on dark matter decay rates and annihilation cross sections are presented. Implications for gravitino dark matter in presence of small R-parity violation are discussed, as well as the impact of our results on the prospect for seeing long-lived neutralinos or staus at the LHC.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1995PhRvB..51..381J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1995PhRvB..51..381J"><span>Spin <span class="hlt">flux</span> and magnetic solitons in an interacting two-dimensional <span class="hlt">electron</span> gas: Topology of two-valued wave functions</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>John, Sajeev; Golubentsev, Andrey</p> <p>1995-01-01</p> <p>It is suggested that an interacting many-<span class="hlt">electron</span> system in a two-dimensional lattice may condense into a topological magnetic state distinct from any discussed previously. This condensate exhibits local spin-1/2 magnetic moments on the lattice sites but is composed of a Slater determinant of single-<span class="hlt">electron</span> wave functions which exist in an orthogonal sector of the <span class="hlt">electronic</span> Hilbert space from the sector describing traditional spin-density-wave or spiral magnetic states. These one-<span class="hlt">electron</span> spinor wave functions have the distinguishing property that they are antiperiodic along a closed path encircling any elementary plaquette of the lattice. This corresponds to a 2π rotation of the internal coordinate frame of the <span class="hlt">electron</span> as it encircles the plaquette. The possibility of spinor wave functions with spatial antiperiodicity is a direct consequence of the two-valuedness of the internal <span class="hlt">electronic</span> wave function defined on the space of Euler angles describing its spin. This internal space is the topologically, doubly-connected, group manifold of SO(3). Formally, these antiperiodic wave functions may be described by passing a <span class="hlt">flux</span> which couples to spin (rather than charge) through each of the elementary plaquettes of the lattice. When applied to the two-dimensional Hubbard model with one <span class="hlt">electron</span> per site, this new topological magnetic state exhibits a relativistic spectrum for charged, quasiparticle excitations with a suppressed one-<span class="hlt">electron</span> density of states at the Fermi level. For a topological antiferromagnet on a square lattice, with the standard Hartree-Fock, spin-density-wave decoupling of the on-site Hubbard interaction, there is an exact mapping of the low-energy one-<span class="hlt">electron</span> excitation spectrum to a relativistic Dirac continuum field theory. In this field theory, the Dirac mass gap is precisely the Mott-Hubbard charge gap and the continuum field variable is an eight-component Dirac spinor describing the components of physical <span class="hlt">electron</span>-spin amplitude on each of</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017ATel10791....1T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017ATel10791....1T"><span>Fermi-<span class="hlt">LAT</span> detection of increased gamma-ray activity of TXS 0506+056, located inside the IceCube-170922A error region.</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Tanaka, Yasuyuki T.; Buson, Sara; Kocevski, Daniel</p> <p>2017-09-01</p> <p>We searched for Fermi-<span class="hlt">LAT</span> sources inside the extremely high-energy (EHE) IceCube-170922A neutrino event error region (https://gcn.gsfc.nasa.gov/gcn3/21916.gcn3, see also ATels 10773, 10787) with all-sky survey data from the Large Area Telescope (<span class="hlt">LAT</span>), on board the Fermi Gamma-ray Space Telescope.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/25769949','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/25769949"><span>miR-21 modulates resistance of HR-HPV positive cervical cancer cells to radiation through targeting <span class="hlt">LATS</span>1.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Liu, Shikai; Song, Lili; Zhang, Liang; Zeng, Saitian; Gao, Fangyuan</p> <p>2015-04-17</p> <p>Although multiple miRNAs are found involved in radioresistance development in HR-HPV positive (+) cervical cancer, only limited studies explored the regulative mechanism of the miRNAs. miR-21 is one of the miRNAs significantly upregulated in HR-HPV (+) cervical cancer is also significantly associated with radioresistance. However, the detailed regulative network of miR-21 in radioresistance is still not clear. In this study, we confirmed that miR-21 overexpression was associated with higher level of radioresistance in HR-HPV (+) cervical cancer patients and thus decided to further explore its role. Findings of this study found miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells and decrease radiation induced G2/M block and increase S phase accumulation. By using dual luciferase assay, we verified a binding site between miR-21 and 3'-UTR of large tumor suppressor kinase 1 (<span class="hlt">LATS</span>1). Through direct binding, miR-21 can regulate <span class="hlt">LATS</span>1 expression in cervical cancer cells. <span class="hlt">LATS</span>1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment. These results suggested that miR-21-<span class="hlt">LATS</span>1 axis plays an important role in regulating radiosensitivity. Copyright © 2015 Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20170003553&hterms=six&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dsix','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20170003553&hterms=six&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dsix"><span>Deep View of the Large Magellanic Cloud with Six Years of Fermi-<span class="hlt">LAT</span> Observations</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ackermann, M.; Albert, A.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bellazzini, R.; Bissaldi, E.; Bloom, E. D.; <a style="text-decoration: none; " href="javascript:void(0); " onClick="displayelement('author_20170003553'); toggleEditAbsImage('author_20170003553_show'); toggleEditAbsImage('author_20170003553_hide'); "> <img style="display:inline; width:12px; height:12px; " src="images/arrow-up.gif" width="12" height="12" border="0" alt="hide" id="author_20170003553_show"> <img style="width:12px; height:12px; display:none; " src="images/arrow-down.gif" width="12" height="12" border="0" alt="hide" id="author_20170003553_hide"></p> <p>2016-01-01</p> <p>Context. The nearby Large Magellanic Cloud (LMC) provides a rare opportunity of a spatially resolved view of an external star-forming galaxy in gamma-rays. The LMC was detected at 0.1-100 GeV as an extended source with CGRO/EGRET and using early observations with the Fermi-<span class="hlt">LAT</span>. The emission was found to correlate with massive star-forming regions and to be particularly bright towards 30 Doradus. Aims. Studies of the origin and transport of cosmic rays (CRs) in the Milky Way are frequently hampered by line-of-sight confusion and poor distance determination. The LMC offers a complementary way to address these questions by revealing whether and how the gamma-ray emission is connected to specific objects, populations of objects, and structures in the galaxy. Methods. We revisited the gamma-ray emission from the LMC using about 73 months of Fermi-<span class="hlt">LAT</span> P7REP data in the 0.2-100 GeV range. We developed a complete spatial and spectral model of the LMC emission, for which we tested several approaches: a simple geometrical description, template-fitting, and a physically driven model for CR-induced interstellar emission. Results. In addition to identifying PSR J0540-6919 through its pulsations, we find two hard sources positionally coincident with plerion N 157B and supernova remnant N 132D, which were also detected at TeV energies with H.E.S.S. We detect an additional soft source that is currently unidentified. Extended emission dominates the total <span class="hlt">flux</span> from the LMC. It consists of an extended component of about the size of the galaxy and additional emission from three to four regions with degree-scale sizes. If it is interpreted as CRs interacting with interstellar gas, the large-scale emission implies a large-scale population of approximately 1-100 GeV CRs with a density of approximately 30% of the local Galactic value. On top of that, the three to four small-scale emission regions would correspond to enhancements of the CR density by factors 2 to 6 or higher, possibly more</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1355679-deep-view-large-magellanic-cloud-six-years-fermi-lat-observations','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1355679-deep-view-large-magellanic-cloud-six-years-fermi-lat-observations"><span>Deep view of the Large Magellanic Cloud with six years of Fermi -<span class="hlt">LAT</span> observations</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Ackermann, M.</p> <p>2016-01-27</p> <p>Context. The nearby Large Magellanic Cloud (LMC) provides a rare opportunity of a spatially resolved view of an external star-forming galaxy in -rays. The LMC was detected at 0.1–100 GeV as an extended source with CGRO/EGRET and using early observations with the Fermi-<span class="hlt">LAT</span>. The emission was found to correlate with massive star-forming regions and to be particularly bright towards 30 Doradus. Aims. Studies of the origin and transport of cosmic rays (CRs) in the Milky Way are frequently hampered by line-of-sight confusion and poor distance determination. The LMC offers a complementary way to address these questions by revealing whether andmore » how the -ray emission is connected to specific objects, populations of objects, and structures in the galaxy. Methods. We revisited the -ray emission from the LMC using about 73 months of Fermi-<span class="hlt">LAT</span> P7REP data in the 0.2–100 GeV range. We developed a complete spatial and spectral model of the LMC emission, for which we tested several approaches: a simple geometrical description, template-fitting, and a physically driven model for CR-induced interstellar emission. Results. In addition to identifying PSR J0540-6919 through its pulsations, we find two hard sources positionally coincident with plerion N 157B and supernova remnant N 132D, which were also detected at TeV energies with H.E.S.S. We detect an additional soft source that is currently unidentified. Extended emission dominates the total <span class="hlt">flux</span> from the LMC. It consists of an extended component of about the size of the galaxy and additional emission from three to four regions with degree-scale sizes. If it is interpreted as CRs interacting with interstellar gas, the large-scale emission implies a large-scale population of ~1–100GeV CRs with a density of ~30% of the local Galactic value. On top of that, the three to four small-scale emission regions would correspond to enhancements of the CR density by factors 2 to 6 or higher, possibly more energetic and younger</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_17 --> <div id="page_18" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="341"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFMSM43B2714K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFMSM43B2714K"><span>Variation Process of Radiation Belt <span class="hlt">Electron</span> <span class="hlt">Fluxes</span> due to Interaction With Chorus and EMIC Rising-tone Emissions Localized in Longitude</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kubota, Y.; Omura, Y.</p> <p>2017-12-01</p> <p>Using results of test particle simulations of a large number of <span class="hlt">electrons</span> interacting with a pair of chorus emissions, we create Green's functions to model the <span class="hlt">electron</span> distribution function after all of the possible interactions with the waves [Omura et al., 2015]. Assuming that the waves are generated in a localized range of longitudes in the dawn side, we repeat taking the convolution integral of the Green's function with the distribution function of the <span class="hlt">electrons</span> injected into the generation region of the localized waves. From numerical and theoretical analyses, we find that <span class="hlt">electron</span> acceleration process only takes place efficiently below 4 MeV. Because extremely relativistic <span class="hlt">electrons</span> go through the wave generation region rapidly due to grad-B0 and curvature drift, they don't have enough interaction time to be accelerated. In setting up the <span class="hlt">electrons</span> after all interaction with chorus emissions as initial <span class="hlt">electron</span> distribution function, we also compute the loss process of radiation belt <span class="hlt">electron</span> <span class="hlt">fluxes</span> due to interaction with EMIC rising-tone emissions generated in a localized range of longitudes in the dusk side [Kubota and Omura,2017]. References: (1) Omura, Y., Y. Miyashita, M. Yoshikawa, D. Summers, M. Hikishima, Y. Ebihara, and Y. Kubota (2015), Formation process of relativistic <span class="hlt">electron</span> <span class="hlt">flux</span> through interaction with chorus emissions in the Earth's inner magnetosphere, J. Geophys. Res. Space Physics, 120, 9545-9562, doi:10.1002/2015JA021563. (2) Kubota, Y., and Y. Omura (2017), Rapid precipitation of radiation belt <span class="hlt">electrons</span> induced by EMIC rising tone emissions localized in longitude inside and outside the plasmapause, J. Geophys. Res. Space Physics, 122, 293-309, doi:10.1002/2016JA023267.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018RAA....18...40Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018RAA....18...40Z"><span><span class="hlt">Flux</span> and spectral variation characteristics of 3C 454.3 at the GeV band</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zhang, Hai-Ming; Zhang, Jin; Lu, Rui-Jing; Yi, Ting-Feng; Huang, Xiao-Li; Liang, En-Wei</p> <p>2018-04-01</p> <p>We analyze the long-term lightcurve of 3C 454.3 observed with Fermi/<span class="hlt">LAT</span> and investigate its relation to <span class="hlt">flux</span> in the radio, optical and X-ray bands. By fitting the 1-day binned GeV lightcurve with multiple Gaussian functions (MGF), we propose that the typical variability timescale in the GeV band is 1–10 d. The GeV <span class="hlt">flux</span> variation is accompanied by the spectral variation characterized as <span class="hlt">flux</span>-tracking, i.e., “harder when brighter.” The GeV <span class="hlt">flux</span> is correlated with the optical and X-ray <span class="hlt">fluxes</span>, and a weak correlation between γ-ray <span class="hlt">flux</span> and radio <span class="hlt">flux</span> is also observed. The γ-ray <span class="hlt">flux</span> is not correlated with the optical linear polarization degree for the global lightcurves, but they show a correlation for the lightcurves before MJD 56000. The power density spectrum of the global lightcurve shows an obvious turnover at ∼ 7.7 d, which may indicate a typical variability timescale of 3C 454.3 in the γ-ray band. This is also consistent with the derived timescales by fitting the global lightcurve with MGF. The spectral evolution and an increase in the optical linear polarization degree along with the increase in γ-ray <span class="hlt">flux</span> may indicate that the radiation particles are accelerated and the magnetic field is ordered by the shock processes during the outbursts. In addition, the nature of 3C 454.3 may be consistent with a self-organized criticality system, similar to Sagittarius A*, and thus the outbursts could be from plasmoid ejections driven by magnetic reconnection. This may further support the idea that the jet radiation regions are magnetized.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015AGUFMSM21A2456P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015AGUFMSM21A2456P"><span>ULF waves: the main periodicities and their relationships with solar wind structures and magnetospheric <span class="hlt">electron</span> <span class="hlt">flux</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Piersanti, M.; Alberti, T.; Lepreti, F.; Vecchio, A.; Villante, U.; Carbone, V.; Waters, C. L.</p> <p>2015-12-01</p> <p>We use high latitude ULF wave power in the range 2-7 mHz (Pc5 geomagnetic micropulsations), solar wind speed and dynamic pressure, and relativistic magnetospheric <span class="hlt">electron</span> <span class="hlt">flux</span> (E > 0.6 MeV), in the period January - September 2008, in order to detect typical periodicities and physical mechanisms involved into the solar wind-magnetosphere coupling during the declining phase of the 23th solar cycle. Using the Empirical Mode Decomposition (EMD) and applying a statistical test and cross-correlation analysis,we investigate the timescales and the physical mechanisms involved into the solar wind-magnetosphere coupling.Summarizing, we obtain the following results:1. We note the existence of two different timescales into the four datasets which are related to the short-term dynamics, with a characteristic timescale τ<3 days, and to the longer timescale dynamics, with a timescale between 7 and 80 days. The short-term variations could be related to the fluctuations around a characteristic mean value, while longer timescales dynamics can be associated with solar rotational periodicity and mechanisms regarding the occurrence of high-speed streams and corotating interaction regions but also with stream-stream interactions and synodic solar rotation.2. The cross-correlation analysis highlights the relevant role of the dynamical coupling between solar wind and magnetosphere via pressure balance and direct transfer of compressional waves into the magnetosphere. Moreover, it shows that the Kelvin-Helmholtz instability is not the primary source of geomagnetic ultra-low frequency wave activity. These results are in agreement with previous works [Engebretson et al, 1998].3. The cross-correlation coefficient between Pc5 wave power and relativistic <span class="hlt">electron</span> <span class="hlt">flux</span> longscale reconstructions shows that Pc5 wave activity leads enhancements in magnetospheric <span class="hlt">electron</span> <span class="hlt">flux</span> to relativistic energy with a characteristic time delay of about 54 hours, which is in agreement with the lag of about 2</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29730476','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29730476"><span>AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors <span class="hlt">LATS</span> 1 and 2.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Philippe, Chloé; Pinson, Benoît; Dompierre, Jim; Pantesco, Véronique; Viollet, Benoît; Daignan-Fornier, Bertrand; Moenner, Michel</p> <p>2018-06-01</p> <p>AICAR (Acadesine) is a pharmacological precursor of purine nucleotide biosynthesis with anti-tumoral properties. Although recognized as an AMP mimetic activator of the protein kinase AMPK, the AICAR monophosphate derivative ZMP was also shown to mediate AMPK-independent effects. In order to unveil these AMPK-independent functions, we performed a transcriptomic analysis in AMPKα1/α2 double knockout murine embryonic cells. Kinetic analysis of the cellular response to AICAR revealed the up-regulation of the large tumor suppressor kinases (<span class="hlt">Lats</span>) 1 and 2 transcripts, followed by the repression of numerous genes downstream of the transcriptional regulators Yap1 and Taz. This transcriptional signature, together with the observation of increased levels in phosphorylation of <span class="hlt">Lats</span>1 and Yap1 proteins, suggested that the Hippo signaling pathway was activated by AICAR. This effect was observed in both fibroblasts and epithelial cells. Knockdown of <span class="hlt">Lats</span>1/2 prevented the cytoplasmic delocalization of Yap1/Taz proteins in response to AICAR and conferred a higher resistance to the drug. These results indicate that activation of the most downstream steps of the Hippo cascade participates to the antiproliferative effects of AICAR. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018ApJ...860...69C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018ApJ...860...69C"><span>Leaked GeV CRs from a Broken Shell: Explaining 9 Years of Fermi-<span class="hlt">LAT</span> Data of SNR W28</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Cui, Yudong; Yeung, Paul K. H.; Tam, P. H. Thomas; Pühlhofer, Gerd</p> <p>2018-06-01</p> <p>Supernova remnant (SNR)W28 is well known for its classic hadronic scenario, in which the TeV cosmic rays (CRs) released at the early stage of this intermediate-age SNR illuminate nearby molecular clouds (MCs). Overwhelming evidence has shown that the northeastern part of the SNR (W28-North) has already encountered the MC clumps. Through this broken shell W28-North, CRs with an energy down to <1 GeV may be able to be injected into nearby MCs. To further verify this hadronic scenario, we first analyze nine years of Fermi-<span class="hlt">LAT</span> data in/around W28 with energies down to 0.3 GeV. Our Fermi-<span class="hlt">LAT</span> analysis displays a 10–200 GeV skymap that spatially matches the known TeV sources HESS J1801–233 (W28-North) and HESS J1800–240 A, B, and C (240 A B and C) well. At low energy bands, we have discovered a 0.5–1 GeV blob located to the south of 240 B and C, and a low <span class="hlt">flux</span> of 0.3–1 GeV at 240 A. A hadronic model is build to explain our analysis results and previous multiwavelength observations of W28. Our model consists of three CR sources: the run-away CRs escaped from a strong shock, the leaked GeV CRs from the broken shell W28-North, and the local CR sea. Through modeling the SNR evolution and the CR acceleration and release, we explain the GeV–TeV emission in/around SNR W28 (except for 240 A) in one model. The damping of the magnetic waves by the neutrals and the decreased acceleration efficiency are both taken into account in our model due to the intermediate age of SNR W28.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2926458','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2926458"><span>Monitoring Mitochondrial <span class="hlt">Electron</span> <span class="hlt">Fluxes</span> Using NAD(P)H-Flavoprotein Fluorometry Reveals Complex Action of Isoflurane on Cardiomyocytes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Sedlic, Filip; Pravdic, Danijel; Hirata, Naoyuki; Mio, Yasushi; Sepac, Ana; Camara, Amadou K.; Wakatsuki, Tetsuro; Bosnjak, Zeljko J.; Bienengraeber, Martin</p> <p>2010-01-01</p> <p>Mitochondrial bioenergetic studies mostly rely on isolated mitochondria thus excluding the regulatory role of other cellular compartments important for the overall mitochondrial function. In intact cardiomyocytes, we followed the dynamics of <span class="hlt">electron</span> <span class="hlt">fluxes</span> along specific sites of the <span class="hlt">electron</span> transport chain (ETC) by simultaneous detection of NAD(H)P and flavoprotein (FP) fluorescence intensities using a laser-scanning confocal microscope. This method was used to delineate the effects of isoflurane, a volatile anesthetic and cardioprotective agent, on the ETC. Comparison to the effects of well-characterized ETC inhibitors and uncoupling agent revealed two distinct effects of isoflurane: uncoupling-induced mitochondrial depolarization and inhibition of ETC at the level of complex I. In correlation, oxygen consumption measurements in cardiomyocytes confirmed a dose-dependent, dual effect of isoflurane, and in isolated mitochondria an obstruction of the ETC primarily at the level of complex I. These effects are likely responsible for the reported mild stimulation of mitochondrial reactive oxygen species (ROS) production required for the cardioprotective effects of isoflurane. In conclusion, isoflurane exhibits complex effects on the ETC in intact cardiomyocytes, altering its <span class="hlt">electron</span> <span class="hlt">fluxes</span>, and thereby enhancing ROS production. The NAD(P)H-FP fluorometry is a useful method for exploring the effect of drugs on mitochondria and identifying their specific sites of action within the ETC of intact cardiomyocytes. PMID:20646994</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1357566-fermi-large-area-telescope-observations-vela-pulsar-wind-nebula','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1357566-fermi-large-area-telescope-observations-vela-pulsar-wind-nebula"><span>FERMI large area telescope observations of the vela-x pulsar wind nebula</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Abdo, A. A.; Ackermann, M.; Ajello, M.; ...</p> <p>2010-03-18</p> <p>Here, we report on gamma-ray observations in the off-pulse window of the Vela pulsar PSR B0833–45 using 11 months of survey data from the Fermi Large Area Telescope (<span class="hlt">LAT</span>). This pulsar is located in the 8° diameter Vela supernova remnant, which contains several regions of non-thermal emission detected in the radio, X-ray, and gamma-ray bands. The gamma-ray emission detected by the <span class="hlt">LAT</span> lies within one of these regions, the 2° × 3° area south of the pulsar known as Vela-X. The <span class="hlt">LAT</span> <span class="hlt">flux</span> is significantly spatially extended with a best-fit radius of 0°more » $$_.$$88 ± 0°$$_.$$12 for an assumed radially symmetric uniform disk. The 200 MeV to 20 GeV <span class="hlt">LAT</span> spectrum of this source is well described by a power law with a spectral index of 2.41 ± 0.09 ± 0.15 and integral <span class="hlt">flux</span> above 100 MeV of (4.73 ± 0.63 ± 1.32) × 10 –7 cm –2 s –1. The first errors represent the statistical error on the fit parameters, while the second ones are the systematic uncertainties. Detailed morphological and spectral analyses give strong constraints on the energetics and magnetic field of the pulsar wind nebula system and favor a scenario with two distinct <span class="hlt">electron</span> populations.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20090007929&hterms=magnetic+particles&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dmagnetic%2Bparticles','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20090007929&hterms=magnetic+particles&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dmagnetic%2Bparticles"><span>Analysis of the Variation of Energetic <span class="hlt">Electron</span> <span class="hlt">Flux</span> with Respect to Longitude and Distance Normal to the Magnetic Equatorial Plane for Galileo Energetic Particle Detector Data</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Swimm, Randall; Garrett, Henry B.; Jun, Insoo; Evans, Robin W.</p> <p>2004-01-01</p> <p>In this study we examine ten-minute omni-directional averages of energetic <span class="hlt">electron</span> data measured by the Galileo spacecraft Energetic Particle Detector (EPD). Count rates from <span class="hlt">electron</span> channels B1, DC2, and DC3 are evaluated using a power law model to yield estimates of the differential <span class="hlt">electron</span> <span class="hlt">fluxes</span> from 1 MeV to 11 MeV at distances between 8 and 51 Jupiter radii. Whereas the orbit of the Galileo spacecraft remained close to the rotational equatorial plane of Jupiter, the approximately 11 degree tilt of the magnetic axis of Jupiter relative to its rotational axis allowed the EPD instrument to sample high energy <span class="hlt">electrons</span> at limited distances normal to the magnetic equatorial plane. We present a Fourier analysis of the semi-diurnal variation of <span class="hlt">electron</span> <span class="hlt">fluxes</span> with longitude.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20160005333&hterms=ballet&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dballet','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20160005333&hterms=ballet&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dballet"><span>The First Fermi-<span class="hlt">LAT</span> Catalog of Sources Above 10 GeV</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ackermann, M.; Ajello, M.; Allafort, A.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Moiseev, Alexander A.</p> <p>2013-01-01</p> <p>We present a catalog of gamma-ray sources at energies above 10 GeV based on data from the Large Area Telescope (<span class="hlt">LAT</span>) accumulated during the first 3 yr of the Fermi Gamma-ray Space Telescope mission. The first Fermi-<span class="hlt">LAT</span> catalog of >10 GeV sources (1FHL) has 514 sources. For each source we present location, spectrum, a measure of variability, and associations with cataloged sources at other wavelengths. We found that 449 (87%) could be associated with known sources, of which 393 (76% of the 1FHL sources) are active galactic nuclei. Of the 27 sources associated with known pulsars, we find 20 (12) to have significant pulsations in the range >10 GeV (>25 GeV). In this work we also report that, at energies above 10 GeV, unresolved sources account for 27% +/- 8% of the isotropic ? -ray background, while the unresolved Galactic population contributes only at the few percent level to the Galactic diffuse background. We also highlight the subset of the 1FHL sources that are best candidates for detection at energies above 50-100 GeV with current and future ground-based ? -ray observatories.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22462044-mir-mir-simultaneously-target-lats2-regulate-proliferation-invasion-gastric-adenocarcinoma-gac-cells','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22462044-mir-mir-simultaneously-target-lats2-regulate-proliferation-invasion-gastric-adenocarcinoma-gac-cells"><span>miR-107 and miR-25 simultaneously target <span class="hlt">LATS</span>2 and regulate proliferation and invasion of gastric adenocarcinoma (GAC) cells</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Zhang, Mingjun; Wang, Xiaolei; Li, Wanhu</p> <p></p> <p>Although a series of oncogenes and tumor suppressors were identified in the pathological development of gastric adenocarcinoma (GAC), the underlying molecule mechanism were still not fully understood. The current study explored the expression profile of miR-107 and miR-25 in GAC patients and their downstream regulative network. qRT-PCR analysis was performed to quantify the expression of these two miRNAs in serum samples from both patients and healthy controls. Dual luciferase assay was conducted to verify their putative bindings with <span class="hlt">LATS</span>2. MTT assay, cell cycle assay and transwell assay were performed to explore how miR-107 and miR-25 regulate proliferation and invasion ofmore » gastric cancer cells. Findings of this study demonstrated that total miR-107 or miR-25 expression might be overexpressed in gastric cancer patients and they can simultaneously and synchronically regulate <span class="hlt">LATS</span>2 expression, thereby affecting gastric cancer cell growth and invasion. Therefore, the miR-25/miR-107-<span class="hlt">LATS</span>2 axis might play an important role in proliferation and invasion of the gastric cancer cells. - Highlights: • Total miR-107 and miR-25 expression is significantly increased in GAC patients. • Both miR-107 and miR-25 can promote proliferation and invasion of GAC cells. • Both miR-107 and miR-25 can target <span class="hlt">LATS</span>2 and regulate its expression. • miR-107 and miR-25 regulate proliferation and invasion of GAC cells though <span class="hlt">LATS</span>2.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20170003242&hterms=comparative&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dcomparative','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20170003242&hterms=comparative&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dcomparative"><span>Comparative Analysis of NOAA REFM and SNB3GEO Tools for the Forecast of the <span class="hlt">Fluxes</span> of High-Energy <span class="hlt">Electrons</span> at GEO</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Balikhin, M. A.; Rodriguez, J. V.; Boynton, R. J.; Walker, S. N.; Aryan, Homayon; Sibeck, D. G.; Billings, S. A.</p> <p>2016-01-01</p> <p>Reliable forecasts of relativistic <span class="hlt">electrons</span> at geostationary orbit (GEO) are important for the mitigation of their hazardous effects on spacecraft at GEO. For a number of years the Space Weather Prediction Center at NOAA has provided advanced online forecasts of the fluence of <span class="hlt">electrons</span> with energy >2 MeV at GEO using the Relativistic <span class="hlt">Electron</span> Forecast Model (REFM). The REFM forecasts are based on real-time solar wind speed observations at L1. The high reliability of this forecasting tool serves as a benchmark for the assessment of other forecasting tools. Since 2012 the Sheffield SNB3GEO model has been operating online, providing a 24 h ahead forecast of the same <span class="hlt">fluxes</span>. In addition to solar wind speed, the SNB3GEO forecasts use solar wind density and interplanetary magnetic field B(sub z) observations at L1. The period of joint operation of both of these forecasts has been used to compare their accuracy. Daily averaged measurements of <span class="hlt">electron</span> <span class="hlt">fluxes</span> by GOES 13 have been used to estimate the prediction efficiency of both forecasting tools. To assess the reliability of both models to forecast infrequent events of very high <span class="hlt">fluxes</span>, the Heidke skill score was employed. The results obtained indicate that SNB3GEO provides a more accurate 1 day ahead forecast when compared to REFM. It is shown that the correction methodology utilized by REFM potentially can improve the SNB3GEO forecast.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27642268','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27642268"><span>Comparative analysis of NOAA REFM and SNB3GEO tools for the forecast of the <span class="hlt">fluxes</span> of high-energy <span class="hlt">electrons</span> at GEO.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Balikhin, M A; Rodriguez, J V; Boynton, R J; Walker, S N; Aryan, H; Sibeck, D G; Billings, S A</p> <p>2016-01-01</p> <p>Reliable forecasts of relativistic <span class="hlt">electrons</span> at geostationary orbit (GEO) are important for the mitigation of their hazardous effects on spacecraft at GEO. For a number of years the Space Weather Prediction Center at NOAA has provided advanced online forecasts of the fluence of <span class="hlt">electrons</span> with energy >2 MeV at GEO using the Relativistic <span class="hlt">Electron</span> Forecast Model (REFM). The REFM forecasts are based on real-time solar wind speed observations at L1. The high reliability of this forecasting tool serves as a benchmark for the assessment of other forecasting tools. Since 2012 the Sheffield SNB 3 GEO model has been operating online, providing a 24 h ahead forecast of the same <span class="hlt">fluxes</span>. In addition to solar wind speed, the SNB 3 GEO forecasts use solar wind density and interplanetary magnetic field B z observations at L1.The period of joint operation of both of these forecasts has been used to compare their accuracy. Daily averaged measurements of <span class="hlt">electron</span> <span class="hlt">fluxes</span> by GOES 13 have been used to estimate the prediction efficiency of both forecasting tools. To assess the reliability of both models to forecast infrequent events of very high <span class="hlt">fluxes</span>, the Heidke skill score was employed. The results obtained indicate that SNB 3 GEO provides a more accurate 1 day ahead forecast when compared to REFM. It is shown that the correction methodology utilized by REFM potentially can improve the SNB 3 GEO forecast.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1357229-anisotropies-diffuse-gamma-ray-background-from-dark-matter-fermi-lat-closer-look','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1357229-anisotropies-diffuse-gamma-ray-background-from-dark-matter-fermi-lat-closer-look"><span>Anisotropies in the diffuse gamma-ray background from dark matter with Fermi <span class="hlt">LAT</span>: A closer look</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Cuoco, A.; Sellerholm, A.; Conrad, J.; ...</p> <p>2011-06-21</p> <p>We perform a detailed study of the sensitivity to the anisotropies related to dark matter (DM) annihilation in the isotropic gamma-ray background (IGRB) as measured by the Fermi Large Area Telescope ( Fermi <span class="hlt">LAT</span>). For the first time, we take into account the effects of the Galactic foregrounds and use a realistic representation of the Fermi <span class="hlt">LAT</span>. We implement an analysis pipeline which simulates Fermi <span class="hlt">LAT</span> data sets starting from model maps of the Galactic foregrounds, the Fermi-resolved point sources, the extragalactic diffuse emission and the signal from DM annihilation. The effects of the detector are taken into account bymore » convolving the model maps with the Fermi <span class="hlt">LAT</span> instrumental response. We then use the angular power spectrum to characterize the anisotropy properties of the simulated data and to study the sensitivity to DM. We consider DM anisotropies of extragalactic origin and of Galactic origin (which can be generated through annihilation in the Milky Way substructures) as opposed to a background of anisotropies generated by sources of astrophysical origin, blazars for example. We find that with statistics from 5 yr of observation, Fermi is sensitive to a DM contribution at the level of 1–10 per cent of the measured IGRB depending on the DM mass m χ and annihilation mode. In terms of the thermally averaged cross-section , this corresponds to ~10 –25 cm 3 s –1, i.e. slightly above the typical expectations for a thermal relic, for low values of the DM mass m χ≲ 100 GeV. As a result, the anisotropy method for DM searches has a sensitivity comparable to the usual methods based only on the energy spectrum and thus constitutes an independent and complementary piece of information in the DM puzzle.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22679957-search-sharp-smooth-spectral-signatures-ssm-gravitino-dark-matter-fermi-lat','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22679957-search-sharp-smooth-spectral-signatures-ssm-gravitino-dark-matter-fermi-lat"><span>Search for sharp and smooth spectral signatures of μνSSM gravitino dark matter with Fermi-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Gómez-Vargas, Germán A.; López-Fogliani, Daniel E.; Perez, Andres D.</p> <p></p> <p>The μνSSM solves the μ problem of supersymmetric models and reproduces neutrino data, simply using couplings with right-handed neutrinos ν's. Given that these couplings break explicitly R parity, the gravitino is a natural candidate for decaying dark matter in the μνSSM. In this work we carry out a complete analysis of the detection of μνSSM gravitino dark matter through γ-ray observations. In addition to the two-body decay producing a sharp line, we include in the analysis the three-body decays producing a smooth spectral signature. We perform first a deep exploration of the low-energy parameter space of the μνSSM taking intomore » account that neutrino data must be reproduced. Then, we compare the γ-ray <span class="hlt">fluxes</span> predicted by the model with Fermi -<span class="hlt">LAT</span> observations. In particular, with the 95% CL upper limits on the total diffuse extragalactic γ-ray background using 50 months of data, together with the upper limits on line emission from an updated analysis using 69.9 months of data. For standard values of bino and wino masses, gravitinos with masses larger than about 4 GeV, or lifetimes smaller than about 10{sup 28} s, produce too large <span class="hlt">fluxes</span> and are excluded as dark matter candidates. However, when limiting scenarios with large and close values of the gaugino masses are considered, the constraints turn out to be less stringent, excluding masses larger than 17 GeV and lifetimes smaller than 4 × 10{sup 25} s.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JCAP...03..047G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JCAP...03..047G"><span>Search for sharp and smooth spectral signatures of μνSSM gravitino dark matter with Fermi-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gómez-Vargas, Germán A.; López-Fogliani, Daniel E.; Muñoz, Carlos; Perez, Andres D.; Ruiz de Austri, Roberto</p> <p>2017-03-01</p> <p>The μνSSM solves the μ problem of supersymmetric models and reproduces neutrino data, simply using couplings with right-handed neutrinos ν's. Given that these couplings break explicitly R parity, the gravitino is a natural candidate for decaying dark matter in the μνSSM. In this work we carry out a complete analysis of the detection of μνSSM gravitino dark matter through γ-ray observations. In addition to the two-body decay producing a sharp line, we include in the analysis the three-body decays producing a smooth spectral signature. We perform first a deep exploration of the low-energy parameter space of the μνSSM taking into account that neutrino data must be reproduced. Then, we compare the γ-ray <span class="hlt">fluxes</span> predicted by the model with Fermi-<span class="hlt">LAT</span> observations. In particular, with the 95% CL upper limits on the total diffuse extragalactic γ-ray background using 50 months of data, together with the upper limits on line emission from an updated analysis using 69.9 months of data. For standard values of bino and wino masses, gravitinos with masses larger than about 4 GeV, or lifetimes smaller than about 1028 s, produce too large <span class="hlt">fluxes</span> and are excluded as dark matter candidates. However, when limiting scenarios with large and close values of the gaugino masses are considered, the constraints turn out to be less stringent, excluding masses larger than 17 GeV and lifetimes smaller than 4 × 1025 s.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22654558-new-alma-fermi-lat-observations-large-scale-jet-pks-strengthen-case-against-ic-cmb-model','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22654558-new-alma-fermi-lat-observations-large-scale-jet-pks-strengthen-case-against-ic-cmb-model"><span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Meyer, Eileen T.; Breiding, Peter; Georganopoulos, Markos</p> <p></p> <p>The Chandra X-ray observatory has discovered several dozen anomalously X-ray-bright jets associated with powerful quasars. A popular explanation for the X-ray <span class="hlt">flux</span> from the knots in these jets is that relativistic synchrotron-emitting <span class="hlt">electrons</span> inverse-Compton scatter cosmic microwave background (CMB) photons to X-ray energies (the IC/CMB model). This model predicts a high gamma-ray <span class="hlt">flux</span> that should be detectable by the Fermi /Large Area Telescope (<span class="hlt">LAT</span>) for many sources. GeV-band upper limits from Fermi /<span class="hlt">LAT</span> for the well-known anomalous X-ray jet in PKS 0637−752 were previously shown in Meyer et al. to violate the predictions of the IC/CMB model. Previously, measurements ofmore » the jet synchrotron spectrum, important for accurately predicting the gamma-ray <span class="hlt">flux</span> level, were lacking between radio and infrared wavelengths. Here, we present new Atacama Large Millimeter/submillimeter Array (ALMA) observations of the large-scale jet at 100, 233, and 319 GHz, which further constrain the synchrotron spectrum, supporting the previously published empirical model. We also present updated limits from the Fermi /<span class="hlt">LAT</span> using the new “Pass 8” calibration and approximately 30% more time on source. With these deeper limits, we rule out the IC/CMB model at the 8.7 σ level. Finally, we demonstrate that complete knowledge of the synchrotron SED is critical in evaluating the IC/CMB model.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JCAP...01..021B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JCAP...01..021B"><span>Fermi-<span class="hlt">LAT</span> kills dark matter interpretations of AMS-02 data. Or not?</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Belotsky, Konstantin; Budaev, Ruslan; Kirillov, Alexander; Laletin, Maxim</p> <p>2017-01-01</p> <p>A number of papers attempt to explain the positron anomaly in cosmic rays, observed by PAMELA and AMS-02, in terms of dark matter (DM) decays or annihilations. However, the recent progress in cosmic gamma-ray studies challenges these attempts. Indeed, as we show, any rational DM model explaining the positron anomaly abundantly produces final state radiation and Inverse Compton gamma rays, which inevitably leads to a contradiction with Fermi-<span class="hlt">LAT</span> isotropic diffuse gamma-ray background measurements. Furthermore, the Fermi-<span class="hlt">LAT</span> observation of Milky Way dwarf satellites, supposed to be rich in DM, revealed no significant signal in gamma rays. We propose a generic approach in which the major contribution to cosmic rays comes from the dark matter disc and prove that the tension between the DM origin of the positron anomaly and the cosmic gamma-ray observations can be relieved. We consider both a simple model, in which DM decay/annihilate into charged leptons, and a model-independent minimal case of particle production, and we estimate the optimal thickness of DM disk. Possible mechanisms of formation and its properties are briefly discussed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22679537-inverse-compton-ray-emission-from-tev-blazar-mrk-during-historical-low-flux-state-observed-nustar','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22679537-inverse-compton-ray-emission-from-tev-blazar-mrk-during-historical-low-flux-state-observed-nustar"><span>INVERSE COMPTON X-RAY EMISSION FROM TeV BLAZAR MRK 421 DURING A HISTORICAL LOW-<span class="hlt">FLUX</span> STATE OBSERVED WITH NuSTAR</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Kataoka, Jun; Stawarz, Łukasz, E-mail: kataoka.jun@waseda.jp</p> <p>2016-08-10</p> <p>We report on the detection of excess hard X-ray emission from the TeV BL Lac object Mrk 421 during the historical low-<span class="hlt">flux</span> state of the source in 2013 January. Nuclear Spectroscopic Telescope Array observations were conducted four times between MJD 56294 and MJD 56312 with a total exposure of 80.9 ks. The source <span class="hlt">flux</span> in the 3–40 keV range was nearly constant, except for MJD 56307 when the average <span class="hlt">flux</span> level increased by a factor of three. Throughout the exposure, the X-ray spectra of Mrk 421 were well represented by a steep power-law model with a photon index of Γmore » ≃ 3.1, although a significant excess was noted above 20 keV in the MJD 56302 data when the source was in its faintest state. Moreover, Mrk 421 was detected at more than the 4 σ level in the 40–79 keV count maps for both MJD 56307 and MJD 56302 but not during the remaining two observations. The detected excess hard X-ray emission connects smoothly with the extrapolation of the high-energy γ -ray continuum of the blazar constrained by Fermi -<span class="hlt">LAT</span> during source quiescence. These findings indicate that while the overall X-ray spectrum of Mrk 421 is dominated by the highest-energy tail of the synchrotron continuum, the variable excess hard X-ray emission above 20 keV (on the timescale of a week) is related to the inverse Compton emission component. We discuss the resulting constraints on the variability and spectral properties of the low-energy segment of the <span class="hlt">electron</span> energy distribution in the source.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27751180','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27751180"><span>Legal assessment tool (<span class="hlt">LAT</span>): an interactive tool to address privacy and data protection issues for data sharing.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kuchinke, Wolfgang; Krauth, Christian; Bergmann, René; Karakoyun, Töresin; Woollard, Astrid; Schluender, Irene; Braasch, Benjamin; Eckert, Martin; Ohmann, Christian</p> <p>2016-07-07</p> <p>In an unprecedented rate data in the life sciences is generated and stored in many different databases. An ever increasing part of this data is human health data and therefore falls under data protected by legal regulations. As part of the BioMedBridges project, which created infrastructures that connect more than 10 ESFRI research infrastructures (RI), the legal and ethical prerequisites of data sharing were examined employing a novel and pragmatic approach. We employed concepts from computer science to create legal requirement clusters that enable legal interoperability between databases for the areas of data protection, data security, Intellectual Property (IP) and security of biosample data. We analysed and extracted access rules and constraints from all data providers (databases) involved in the building of data bridges covering many of Europe's most important databases. These requirement clusters were applied to five usage scenarios representing the data flow in different data bridges: Image bridge, Phenotype data bridge, Personalised medicine data bridge, Structural data bridge, and Biosample data bridge. A matrix was built to relate the important concepts from data protection regulations (e.g. pseudonymisation, identifyability, access control, consent management) with the results of the requirement clusters. An interactive user interface for querying the matrix for requirements necessary for compliant data sharing was created. To guide researchers without the need for legal expert knowledge through legal requirements, an interactive tool, the Legal Assessment Tool (<span class="hlt">LAT</span>), was developed. <span class="hlt">LAT</span> provides researchers interactively with a selection process to characterise the involved types of data and databases and provides suitable requirements and recommendations for concrete data access and sharing situations. The results provided by <span class="hlt">LAT</span> are based on an analysis of the data access and sharing conditions for different kinds of data of major databases in Europe</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28766610','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28766610"><span>Optical properties and magnetic <span class="hlt">flux</span>-induced <span class="hlt">electronic</span> band tuning of a T-graphene sheet and nanoribbon.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bandyopadhyay, Arka; Nandy, Atanu; Chakrabarti, Arunava; Jana, Debnarayan</p> <p>2017-08-16</p> <p>Tetragonal graphene (T-graphene) is a theoretically proposed dynamically stable, metallic allotrope of graphene. In this theoretical investigation, a tight binding (TB) model is used to unravel the metal to semiconductor transition of this 2D sheet under the influence of an external magnetic <span class="hlt">flux</span>. In addition, the environment under which the sheet exposes an appreciable direct band gap of 1.41 ± 0.01 eV is examined. Similarly, the <span class="hlt">electronic</span> band structure of the narrowest armchair T-graphene nanoribbon (NATGNR) also gets modified with different combinations of magnetic <span class="hlt">fluxes</span> through the elementary rings. The band tuning parameters are critically identified for both systems. It is observed that the induced band gaps vary remarkably with the tuning parameters. We have also introduced an exact analytical approach to address the band structure of the NATGNR in the absence of any magnetic <span class="hlt">flux</span>. Finally, the optical properties of the sheet and NATGNR are also critically analysed for both parallel and perpendicular polarizations with the help of density functional theory (DFT). Our study predicts that this material and its nanoribbons can be used in optoelectronic devices.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_18 --> <div id="page_19" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="361"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1304819-improved-empirical-model-electron-ion-fluxes-geosynchronous-orbit-based-upstream-solar-wind-conditions','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1304819-improved-empirical-model-electron-ion-fluxes-geosynchronous-orbit-based-upstream-solar-wind-conditions"><span>An improved empirical model of <span class="hlt">electron</span> and ion <span class="hlt">fluxes</span> at geosynchronous orbit based on upstream solar wind conditions</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Denton, M. H.; Henderson, M. G.; Jordanova, V. K.; ...</p> <p>2016-07-01</p> <p>In this study, a new empirical model of the <span class="hlt">electron</span> <span class="hlt">fluxes</span> and ion <span class="hlt">fluxes</span> at geosynchronous orbit (GEO) is introduced, based on observations by Los Alamos National Laboratory (LANL) satellites. The model provides <span class="hlt">flux</span> predictions in the energy range ~1 eV to ~40 keV, as a function of local time, energy, and the strength of the solar wind electric field (the negative product of the solar wind speed and the z component of the magnetic field). Given appropriate upstream solar wind measurements, the model provides a forecast of the <span class="hlt">fluxes</span> at GEO with a ~1 h lead time. Model predictionsmore » are tested against in-sample observations from LANL satellites and also against out-of-sample observations from the Compact Environmental Anomaly Sensor II detector on the AMC-12 satellite. The model does not reproduce all structure seen in the observations. However, for the intervals studied here (quiet and storm times) the normalized root-mean-square deviation < ~0.3. It is intended that the model will improve forecasting of the spacecraft environment at GEO and also provide improved boundary/input conditions for physical models of the magnetosphere.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015JEMat..44.1116V','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015JEMat..44.1116V"><span>Solder <span class="hlt">Flux</span> Residues and Humidity-Related Failures in <span class="hlt">Electronics</span>: Relative Effects of Weak Organic Acids Used in No-Clean <span class="hlt">Flux</span> Systems</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Verdingovas, Vadimas; Jellesen, Morten Stendahl; Ambat, Rajan</p> <p>2015-04-01</p> <p>This paper presents the results of humidity testing of weak organic acids (WOAs), namely adipic, succinic, glutaric, dl-malic, and palmitic acids, which are commonly used as activators in no-clean solder <span class="hlt">fluxes</span>. The study was performed under humidity conditions varying from 60% relative humidity (RH) to ˜99%RH at 25°C. The following parameters were used for characterization of WOAs: mass gain due to water adsorption and deliquescence of the WOA (by quartz crystal microbalance), resistivity of the water layer formed on the printed circuit board (by impedance spectroscopy), and leakage current measured using the surface insulation resistance pattern in the potential range from 0 V to 10 V. The combined results indicate the importance of the WOA chemical structure for the water adsorption and therefore conductive water layer formation on the printed circuit board assembly (PCBA). A substantial increase of leakage currents and probability of electrochemical migration was observed at humidity levels above the RH corresponding to the deliquescence point of WOAs present as contaminants on the printed circuit boards. The results suggest that use of solder <span class="hlt">fluxes</span> with WOAs having higher deliquescence point could improve the reliability of <span class="hlt">electronics</span> operating under circumstances in which exposure to high humidity is likely to occur.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22348508-multiwavelength-observations-tev-binary-ls-+61-veritas-fermi-lat-swift-xrt-during-tev-outburst','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22348508-multiwavelength-observations-tev-binary-ls-+61-veritas-fermi-lat-swift-xrt-during-tev-outburst"><span>Multiwavelength observations of the TeV binary LS I +61° 303 with Veritas, Fermi-<span class="hlt">LAT</span>, and Swift/xrt during a TeV outburst</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Aliu, E.; Archambault, S.; Behera, B.</p> <p>2013-12-10</p> <p>We present the results of a multiwavelength observational campaign on the TeV binary system LS I +61° 303 with the VERITAS telescope array (>200 GeV), Fermi-<span class="hlt">LAT</span> (0.3-300 GeV), and Swift/XRT (2-10 keV). The data were taken from 2011 December through 2012 January and show a strong detection in all three wavebands. During this period VERITAS obtained 24.9 hr of quality selected livetime data in which LS I +61° 303 was detected at a statistical significance of 11.9σ. These TeV observations show evidence for nightly variability in the TeV regime at a post-trial significance of 3.6σ. The combination of the simultaneouslymore » obtained TeV and X-ray <span class="hlt">fluxes</span> do not demonstrate any evidence for a correlation between emission in the two bands. For the first time since the launch of the Fermi satellite in 2008, this TeV detection allows the construction of a detailed MeV-TeV spectral energy distribution from LS I +61° 303. This spectrum shows a distinct cutoff in emission near 4 GeV, with emission seen by the VERITAS observations following a simple power-law above 200 GeV. This feature in the spectrum of LS I +61° 303, obtained from overlapping observations with Fermi-<span class="hlt">LAT</span> and VERITAS, may indicate that there are two distinct populations of accelerated particles producing the GeV and TeV emission.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014EGUGA..16.6154P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014EGUGA..16.6154P"><span>Determination of <span class="hlt">Flux</span>-Gate Magnetometer Spin Axis Offsets with the <span class="hlt">Electron</span> Drift Instrument</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Plaschke, Ferdinand; Nakamura, Rumi; Giner, Lukas; Teubenbacher, Robert; Chutter, Mark; Leinweber, Hannes K.; Magnes, Werner</p> <p>2014-05-01</p> <p>Spin-stabilization of spacecraft enormously supports the in-flight calibration of onboard <span class="hlt">flux</span>-gate magnetometers (FGMs): eight out of twelve calibration parameters can be determined by minimization of spin tone and harmonics in the calibrated magnetic field measurements. From the remaining four parameters, the spin axis offset is usually obtained by analyzing observations of Alfvénic fluctuations in the solar wind. If solar wind measurements are unavailable, other methods for spin axis offset determination need to be used. We present two alternative methods that are based on the comparison of FGM and <span class="hlt">electron</span> drift instrument (EDI) data: (1) EDI measures the gyration periods of instrument-emitted <span class="hlt">electrons</span> in the ambient magnetic field. They are inversely proportional to the magnetic field strength. Differences between FGM and EDI measured field strengths can be attributed to inaccuracies in spin axis offset, if the other calibration parameters are accurately known. (2) For EDI <span class="hlt">electrons</span> to return to the spacecraft, they have to be sent out in perpendicular direction to the ambient magnetic field. Minimization of the variance of <span class="hlt">electron</span> beam directions with respect to the FGM-determined magnetic field direction also yields an estimate of the spin axis offset. Prior to spin axis offset determination, systematic inaccuracies in EDI gyration period measurements and in the transformation of EDI beam directions into the FGM spin-aligned reference coordinate system have to be corrected. We show how this can be done by FGM/EDI data comparison, as well.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016APS..DPPYO8001H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016APS..DPPYO8001H"><span>Classical Heat-<span class="hlt">Flux</span> Measurements in Coronal Plasmas from Collective Thomson-Scattering Spectra</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Henchen, R. J.; Hu, S. X.; Katz, J.; Froula, D. H.; Rozmus, W.</p> <p>2016-10-01</p> <p>Collective Thomson scattering was used to measure heat <span class="hlt">flux</span> in coronal plasmas. The relative amplitude of the Thomson-scattered power into the up- and downshifted <span class="hlt">electron</span> plasma wave features was used to determine the <span class="hlt">flux</span> of <span class="hlt">electrons</span> moving along the temperature gradient at three to four times the <span class="hlt">electron</span> thermal velocity. Simultaneously, the ion-acoustic wave features were measured. Their relative amplitude was used to measure the <span class="hlt">flux</span> of the return-current <span class="hlt">electrons</span>. The frequencies of these ion-acoustic and <span class="hlt">electron</span> plasma wave features provide local measurements of the <span class="hlt">electron</span> temperature and density. These spectra were obtained at five locations along the temperature gradient in a laser-produced blowoff plasma. These measurements of plasma parameters are used to infer the Spitzer-Härm <span class="hlt">flux</span> (qSH = - κ∇Te ) and are in good agreement with the values of the heat <span class="hlt">flux</span> measured from the scattering-feature asymmetries. Additional experiments probed plasma waves perpendicular to the temperature gradient. The data show small effects resulting from heat <span class="hlt">flux</span> compared to probing waves along the temperature gradient. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016A%26A...586A..71A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016A%26A...586A..71A"><span>Deep view of the Large Magellanic Cloud with six years of Fermi-<span class="hlt">LAT</span> observations</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ackermann, M.; Albert, A.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bellazzini, R.; Bissaldi, E.; Bloom, E. D.; Bonino, R.; Brandt, T. J.; Bregeon, J.; Bruel, P.; Buehler, R.; Caliandro, G. A.; Cameron, R. A.; Caragiulo, M.; Caraveo, P. A.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Chekhtman, A.; Chiang, J.; Chiaro, G.; Ciprini, S.; Cohen-Tanugi, J.; Cutini, S.; D'Ammando, F.; de Angelis, A.; de Palma, F.; Desiante, R.; Digel, S. W.; Drell, P. S.; Favuzzi, C.; Ferrara, E. C.; Focke, W. B.; Franckowiak, A.; Fusco, P.; Gargano, F.; Gasparrini, D.; Giglietto, N.; Giordano, F.; Godfrey, G.; Grenier, I. A.; Grondin, M.-H.; Guillemot, L.; Guiriec, S.; Harding, A. K.; Hill, A. B.; Horan, D.; Jóhannesson, G.; Knödlseder, J.; Kuss, M.; Larsson, S.; Latronico, L.; Li, J.; Li, L.; Longo, F.; Loparco, F.; Lubrano, P.; Maldera, S.; Martin, P.; Mayer, M.; Mazziotta, M. N.; Michelson, P. F.; Mizuno, T.; Monzani, M. E.; Morselli, A.; Murgia, S.; Nuss, E.; Ohsugi, T.; Orienti, M.; Orlando, E.; Ormes, J. F.; Paneque, D.; Pesce-Rollins, M.; Piron, F.; Pivato, G.; Porter, T. A.; Rainò, S.; Rando, R.; Razzano, M.; Reimer, A.; Reimer, O.; Romani, R. W.; Sánchez-Conde, M.; Schulz, A.; Sgrò, C.; Siskind, E. J.; Smith, D. A.; Spada, F.; Spandre, G.; Spinelli, P.; Suson, D. J.; Takahashi, H.; Thayer, J. B.; Tibaldo, L.; Torres, D. F.; Tosti, G.; Troja, E.; Vianello, G.; Wood, M.; Zimmer, S.</p> <p>2016-02-01</p> <p>Context. The nearby Large Magellanic Cloud (LMC) provides a rare opportunity of a spatially resolved view of an external star-forming galaxy in γ-rays. The LMC was detected at 0.1-100 GeV as an extended source with CGRO/EGRET and using early observations with the Fermi-<span class="hlt">LAT</span>. The emission was found to correlate with massive star-forming regions and to be particularly bright towards 30 Doradus. Aims: Studies of the origin and transport of cosmic rays (CRs) in the Milky Way are frequently hampered by line-of-sight confusion and poor distance determination. The LMC offers a complementary way to address these questions by revealing whether and how the γ-ray emission is connected to specific objects, populations of objects, and structures in the galaxy. Methods: We revisited the γ-ray emission from the LMC using about 73 months of Fermi-<span class="hlt">LAT</span> P7REP data in the 0.2-100 GeV range. We developed a complete spatial and spectral model of the LMC emission, for which we tested several approaches: a simple geometrical description, template-fitting, and a physically driven model for CR-induced interstellar emission. Results: In addition to identifying PSR J0540-6919 through its pulsations, we find two hard sources positionally coincident with plerion N 157B and supernova remnant N 132D, which were also detected at TeV energies with H.E.S.S. We detect an additional soft source that is currently unidentified. Extended emission dominates the total <span class="hlt">flux</span> from the LMC. It consists of an extended component of about the size of the galaxy and additional emission from three to four regions with degree-scale sizes. If it is interpreted as CRs interacting with interstellar gas, the large-scale emission implies a large-scale population of ~1-100 GeV CRs with a density of ~30% of the local Galactic value. On top of that, the three to four small-scale emission regions would correspond to enhancements of the CR density by factors 2 to 6 or higher, possibly more energetic and younger populations</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015PhPro..61..694G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015PhPro..61..694G"><span>Gamma-ray and Neutrino <span class="hlt">Fluxes</span> from Heavy Dark Matter in the Galactic Center</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gammaldi, V.; Cembranos, J. A. R.; de la Cruz-Dombriz, A.; Lineros, R. A.; Maroto, A. L.</p> <p></p> <p>We present a study of the Galactic Center region as a possible source of both secondary gamma-ray and neutrino <span class="hlt">fluxes</span> from annihilating dark matter. We have studied the gamma-ray <span class="hlt">flux</span> observed by the High Energy Stereoscopic System (HESS) from the J1745-290 Galactic Center source. The data are well fitted as annihilating dark matter in combination with an astrophysical background. The analysis was performed by means of simulated gamma spectra produced by Monte Carlo event generators packages. We analyze the differences in the spectra obtained by the various Monte Carlo codes developed so far in particle physics. We show that, within some uncertainty, the HESS data can be fitted as a signal from a heavy dark matter density distribution peaked at the Galactic Center, with a power-law for the background with a spectral index which is compatible with the Fermi-Large Area Telescope (<span class="hlt">LAT</span>) data from the same region. If this kind of dark matter distribution generates the gamma-ray <span class="hlt">flux</span> observed by HESS, we also expect to observe a neutrino <span class="hlt">flux</span>. We show prospective results for the observation of secondary neutrinos with the Astronomy with a Neutrino Telescope and Abyss environmental RESearch project (ANTARES), Ice Cube Neutrino Observatory (Ice Cube) and the Cubic Kilometer Neutrino Telescope (KM3NeT). Prospects solely depend on the device resolution angle when its effective area and the minimum energy threshold are fixed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/16338960','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/16338960"><span>Photoinactivation of ascorbate peroxidase in isolated tobacco chloroplasts: Galdieria partita APX maintains the <span class="hlt">electron</span> <span class="hlt">flux</span> through the water-water cycle in transplastomic tobacco plants.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Miyake, Chikahiro; Shinzaki, Yuki; Nishioka, Minori; Horiguchi, Sayaka; Tomizawa, Ken-Ichi</p> <p>2006-02-01</p> <p>We evaluated the H2O2-scavenging activity of the water-water cycle (WWC) in illuminated intact chloroplasts isolated from tobacco leaves. Illumination under conditions that limited photosynthesis [red light (>640 nm), 250 micromol photons m(-2) s(-1) in the absence of HCO3-] caused chloroplasts to take up O2 and accumulate H2O2. Concomitant with the O2 uptake, both ascorbate peroxidase (APX) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) lost their activities. However, superoxide dismutase (SOD), monodehydroascorbate radical reductase (MDAR), dehydroascorbate reductase (DHAR) and glutathione reductase (GR) activities remained unaffected. The extent to which the photosynthetic linear <span class="hlt">electron</span> flow decreased was small compared with the decline in APX activity. Therefore, the loss of APX activity lowered the <span class="hlt">electron</span> <span class="hlt">flux</span> through the WWC, as evidenced by a decrease in relative <span class="hlt">electron</span> <span class="hlt">flux</span> through PSII [Phi(PSII)xPFD]. To verify these interpretations, we created a transplastomic tobacco line in which an H2O2-insensitive APX from the red alga, Galdieria partita, was overproduced in the chloroplasts. In intact transplastomic chloroplasts which were illuminated under conditions that limited photosynthesis, neither O2 uptake nor H2O2 accumulation occurred. Furthermore, the <span class="hlt">electron</span> <span class="hlt">flux</span> through the WWC and the activity of GAPDH were maintained. The present work is the first report of APX inactivation by endogenous H2O2 in intact chloroplasts.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2008JASTP..70.1810V','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2008JASTP..70.1810V"><span>Response of the radiation belt <span class="hlt">electron</span> <span class="hlt">flux</span> to the solar wind velocity: Parameterization by radial distance and energy</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Vassiliadis, D.</p> <p>2008-11-01</p> <p>The solar wind velocity is the primary driver of the <span class="hlt">electron</span> <span class="hlt">flux</span> variability in Earth's radiation belts. The response of the logarithmic <span class="hlt">flux</span> ("log-<span class="hlt">flux</span>") to this driver has been determined at the geosynchronous orbit and at a fixed energy [Baker, D.N., McPherron, R.L., Cayton, T.E., Klebesadel, R.W., 1990. Linear prediction filter analysis of relativistic <span class="hlt">electron</span> properties at 6.6 RE. Journal of Geophysical Research 95(A9), 15,133-15,140) and as a function of L shell and fixed energy [Vassiliadis, D., Klimas, A.J., Kanekal, S.G., Baker, D.N., Weigel, R.S., 2002. Long-term average, solar-cycle, and seasonal response of magnetospheric energetic <span class="hlt">electrons</span> to the solar wind speed. Journal of Geophysical Research 107, doi:10.1029/2001JA000506). In this paper we generalize the response model as a function of particle energy (0.8-6.4 MeV) using POLAR HIST measurements. All three response peaks identified earlier figure prominently in the high-altitude POLAR measurements. The positive response around the geosynchronous orbit is peak P1 ([tau]=2±1 d; L=5.8±0.5; E=0.8-6.4 MeV), associated with high-speed, low-density streams and the ULF wave activity they produce. Deeper in the magnetosphere, the response is dominated by a positive peak P0 (0±1 d; 2.9±0.5RE; 0.8-1.1 MeV), of a shorter duration and producing lower-energy <span class="hlt">electrons</span>. The P0 response occurs during the passage of geoeffective structures containing high IMF and high-density parts, such as ICMEs and other mass ejecta. Finally, the negative peak V1 (0±0.5 d; 5.7±0.5RE; 0.8-6.4 MeV) is associated with the "Dst effect" or the quasiadiabatic transport produced by ring-current intensifications. As energies increase, the P1 and V1 peaks appear at lower L, while the Dst effect becomes more pronounced in the region L<3. The P0 effectively disappears for E>1.6 MeV because of low statistics, although it is evident in individual events. The continuity of the response across radial and energy scales supports the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1993STIN...9413730F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1993STIN...9413730F"><span>High <span class="hlt">flux</span> heat exchanger</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Flynn, Edward M.; Mackowski, Michael J.</p> <p>1993-01-01</p> <p>This interim report documents the results of the first two phases of a four-phase program to develop a high <span class="hlt">flux</span> heat exchanger for cooling future high performance aircraft <span class="hlt">electronics</span>. Phase 1 defines future needs for high <span class="hlt">flux</span> heat removal in advanced military <span class="hlt">electronics</span> systems. The results are sorted by broad application categories: (1) commercial digital systems, (2) military data processors, (3) power processors, and (4) radar and optical systems. For applications expected to be fielded in five to ten years, the outlook is for steady state <span class="hlt">flux</span> levels of 30-50 W/sq cm for digital processors and several hundred W/sq cm for power control applications. In Phase 1, a trade study was conducted on emerging cooling technologies which could remove a steady state chip heat <span class="hlt">flux</span> of 100 W/sq cm while holding chip junction temperature to 90 C. Constraints imposed on heat exchanger design, in order to reflect operation in a fighter aircraft environment, included a practical lower limit on coolant supply temperature, the preference for a nontoxic, nonflammable, and nonfreezing coolant, the need to minimize weight and volume, and operation in an accelerating environment. The trade study recommended the Compact High Intensity Cooler (CHIC) for design, fabrication, and test in the final two phases of this program.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1356555-first-fermi-lat-catalog-sources-above-gev','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1356555-first-fermi-lat-catalog-sources-above-gev"><span>The first Fermi-<span class="hlt">LAT</span> catalog of sources above 10 GeV</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Ackermann, M.; Ajello, M.; Allafort, A.; ...</p> <p>2013-11-14</p> <p>Here, we present a catalog of γ-ray sources at energies above 10 GeV based on data from the Large Area Telescope (<span class="hlt">LAT</span>) accumulated during the first 3 yr of the Fermi Gamma-ray Space Telescope mission. The first Fermi-<span class="hlt">LAT</span> catalog of >10 GeV sources (1FHL) has 514 sources. For each source we present location, spectrum, a measure of variability, and associations with cataloged sources at other wavelengths. We found that 449 (87%) could be associated with known sources, of which 393 (76% of the 1FHL sources) are active galactic nuclei. Of the 27 sources associated with known pulsars, we find 20more » (12) to have significant pulsations in the range >10 GeV (>25 GeV). In this work we also report that, at energies above 10 GeV, unresolved sources account for 27% ± 8% of the isotropic γ-ray background, while the unresolved Galactic population contributes only at the few percent level to the Galactic diffuse background. We also highlight the subset of the 1FHL sources that are best candidates for detection at energies above 50-100 GeV with current and future ground-based γ-ray observatories.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1046943','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1046943"><span>Fermi <span class="hlt">LAT</span> Detection of Pulsed Gamma-Rays From the Vela-Like Pulsars PSR J1048-5832 and PSR J2229+6114</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Abdo, A.A.; /Naval Research Lab, Wash., D.C. /Federal City Coll.; Ackermann, M.</p> <p></p> <p>We report the detection of {gamma}-ray pulsations ({ge}0.1 GeV) from PSR J2229+6114 and PSR J1048-5832, the latter having been detected as a low-significance pulsar by EGRET. Data in the {gamma}-ray band were acquired by the Large Area Telescope (<span class="hlt">LAT</span>) aboard the Fermi Gamma-ray Space Telescope, while the radio rotational ephemerides used to fold the {gamma}-ray light curves were obtained using the Green Bank Telescope, the Lovell telescope at Jodrell Bank, and the Parkes Telescope. The two young radio pulsars, located within the error circles of the previously unidentified EGRET sources 3EG J1048-5840 and 3EG J2227+6122, present spin-down characteristics similar tomore » the Vela pulsar. PSR J1048-5832 shows two sharp peaks at phases 0.15 {+-} 0.01 and 0.57 {+-} 0.01 relative to the radio pulse confirming the EGRET light curve, while PSR J2229+6114 presents a very broad peak at phase 0.49 {+-} 0.01. The {gamma}-ray spectra above 0.1 GeV of both pulsars are fit with power laws having exponential cutoffs near 3 GeV, leading to integral photon <span class="hlt">fluxes</span> of (2.19 {+-} 0.22 {+-} 0.32) x 10{sup -7} cm{sup -2} s{sup -1} for PSR J1048-5832 and (3.77 {+-} 0.22 {+-} 0.44) x 10{sup -7} cm{sup -2} s{sup -1} for PSR J2229+6114. The first uncertainty is statistical and the second is systematic. PSR J1048-5832 is one of the two <span class="hlt">LAT</span> sources which were entangled together as 3EG J1048-5840. These detections add to the growing number of young {gamma}-ray pulsars that make up the dominant population of GeV {gamma}-ray sources in the Galactic plane.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014EGUGA..1613929G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014EGUGA..1613929G"><span>Storm-time fingerprints of Pc 4-5 waves on energetic <span class="hlt">electron</span> <span class="hlt">flux</span> at geosynchronous orbit</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Georgiou, Marina; Daglis, Ioannis A.; Zesta, Eftyhia; Balasis, George; Mann, Ian R.; Tsinganos, Kanaris</p> <p>2014-05-01</p> <p>Geospace magnetic storms, associated with either coronal mass ejections (CMEs) or high speed solar streams, involve global variations of the geomagnetic field as well as acceleration of charged particles in the magnetosphere. Ultra low frequency (ULF) waves with frequencies in the range of a few mHz (Pc 4-5 waves) can be generated externally by compressive variations in the solar wind or shear flow along the magnetopause unstable to the Kelvin-Helmholtz effect. Furthermore, low frequency instabilities of ring current ions are also considered as a possible internal driver of ULF wave growth. We examine power enhancements of ULF waves during four successive magnetic storms, which occurred in July 2004 and were characterized by a decreasing minimum of the Dst index, from -76 nT down to -197 nT. During the course of the magnetic storms, ULF wave power variations have been observed nearly simultaneously at different magnetic latitudes and longitudes by the ground-based CARISMA, IMAGE, 210 MM and SAMBA magnetometer networks. Nonetheless, stronger magnetic storms were accompanied by greater ULF wave power enhancements tending to be more pronounced at magnetic stations located at lower L shells. Furthermore, the generation and penetration of ULF wave power deep into the inner magnetosphere seems to be contributing to the energization and transport of relativistic <span class="hlt">electrons</span>. Except for the magnetic storm on 25 July 2000, the three magnetic storms on 17, 23 and 27 July 2004 were characterized by a significant increase in the <span class="hlt">flux</span> of <span class="hlt">electrons</span> with energies higher than 1 MeV, as measured by GOES-10 and -12 during the recovery phase of each storm. On the other hand, when looking at the magnetic storm on 17 August 2001, the initial decrease was followed by an increase six days after the commencement of the storm. The <span class="hlt">electron</span> <span class="hlt">flux</span> decrease was more than two orders of magnitude and remained low after the recovery of the Dst index. These observations provided us the basis for</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28893265','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28893265"><span>Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating <span class="hlt">LATS</span>1 expression.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Zhang, Jing; Liu, Hui; Hou, Lidan; Wang, Ge; Zhang, Rui; Huang, Yanxia; Chen, Xiaoyu; Zhu, Jinshui</p> <p>2017-09-11</p> <p>Non-coding RNAs (ncRNAs) have been shown to regulate gene expression involved in tumor progression of multiple malignancies. Our previous studies indicated that large tumor suppressor kinase 1 (<span class="hlt">LATS</span>1), a core part of Hippo signaling pathway, functions as a tumor suppressor in gastric cancer (GC). But, the underlying molecular mechanisms by which ncRNAs modulate <span class="hlt">LATS</span>1 expression in GC remain undetermined. The correlation of <span class="hlt">LATS</span>1 and has-miR-424-5p (miR-424) expression with clinicopathological characteristics and prognosis of GC patients was analyzed by TCGA RNA-sequencing data. A novel circular RNA_LARP4 (circLARP4) was identified to sponge miR-424 by circRNA expression profile and bioinformatic analysis. The binding site between miR-424 and <span class="hlt">LATS</span>1 or circLARP4 was verified using dual luciferase assay and RNA immunoprecipitation (RIP) assay. The expression and localization of circLARP4 in GC tissues were investigated by fluorescence in situ hybridization (FISH). MTT, colony formation, Transwell and EdU assays were performed to assess the effects of miR-424 or circLARP4 on cell proliferation and invasion. Increased miR-424 expression or decreased <span class="hlt">LATS</span>1 expression was associated with pathological stage and unfavorable prognosis of GC patients. Ectopic expression of miR-424 promoted proliferation and invasion of GC cells by targeting <span class="hlt">LATS</span>1 gene. Furthermore, circLARP4 was mainly localized in the cytoplasm and inhibited biological behaviors of GC cells by sponging miR-424. The expression of circLARP4 was downregulated in GC tissues and represented an independent prognostic factor for overall survival of GC patients. circLARP4 may act as a novel tumor suppressive factor and a potential biomarker in GC.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/29901195','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/29901195"><span>Interaction of S100A1 with <span class="hlt">LATS</span>1 promotes cell growth through regulation of the Hippo pathway in hepatocellular carcinoma.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Guo, Qingping; Wang, Jiale; Cao, Zeyu; Tang, Yongchang; Feng, Chao; Huang, Feizhou</p> <p>2018-06-05</p> <p>Despite advances in surgery and chemotherapy, the prognosis of patients with hepatocellular carcinoma (HCC) remains poor. In the present study, the role of S100A1 in the progression of HCC was investigated. Immunohistochemical staining was used to measure the expression of S100A1 in HCC tissues. S100A1 was knocked down by siRNA. A battery of experiments was used to evaluate the biology functions of S100A1. It was found that S100A1 was upregulated in HCC tissues, and its upregulation was associated with a large tumor size, low differentiation and shorter survival time. The biological experiments demonstrated that S100A1 functions as an oncogene in HCC. It was also found that S100A1 knockdown enhanced the inhibitory effects of cisplatin on HCC cells. The results showed that the downregulation of S100A1 induced the phosphorylation of yes‑associated protein (YAP), and treatment with CHX demonstrated that the downregulation of S100A1 accelerated YAP protein degradation. The downregulation of S100A1 did not alter the expression of mammalian sterile 20‑like kinase (MST)1/2 or phosphorylated MST1/2, but upregulated the phosphorylation of large tumor suppressor kinase 1 (<span class="hlt">LATS</span>1). It was further confirmed that S100A1 interacted with <span class="hlt">LATS</span>1. <span class="hlt">LATS</span>1 depletion significantly reduced the effects of S100A1 on cell growth rate and apoptosis, and there was a positive correlation between phosphorylated <span class="hlt">LATS</span>1 and S100A1 in clinical samples, indicating that <span class="hlt">LATS</span>1 was responsible for the S100A1-induced changes in cancer cell growth and Hippo signaling. In conclusion, the results of the present study indicated that S100A1 functions as an oncogene and may be a biomarker for the prognosis of patients with HCC. S100A1 exerted its oncogenic function by interacting with <span class="hlt">LATS</span>1 and activating YAP. S100A1 may serve as a target for novel therapies in HCC.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018EPJWC.17405001T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018EPJWC.17405001T"><span>Multi-GEM Detectors in High Particle <span class="hlt">Fluxes</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Thuiner, P.; Resnati, F.; Franchino, S.; Gonzalez Diaz, D.; Hall-Wilton, R.; Müller, H.; Oliveri, E.; Pfeiffer, D.; Ropelewski, L.; Van Stenis, M.; Streli, C.; Veenhof, R.</p> <p>2018-02-01</p> <p>Gaseous <span class="hlt">Electron</span> Multipliers (GEM) are well known for stable operation at high particle <span class="hlt">fluxes</span>. We present a study of the intrinsic limits of GEMdetectors when exposed to very high particle <span class="hlt">fluxes</span> of the order of MHz/mm2. We give an interpretation to the variations of the effective gain, which, as a function of the particle <span class="hlt">flux</span>, first increases and then decreases. We also discuss the reduction of the ion back-flow with increasing <span class="hlt">flux</span>. We present measurements and simulations of a triple GEM detector, describing its behaviour in terms of accumulation of positive ions that results in changes of the transfer fields and the amplification fields. The behaviour is expected to be common to all multi-stage amplification devices where the efficiency of transferring the <span class="hlt">electrons</span> from one stage to the next one is not 100%.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22680098-fermi-lat-kills-dark-matter-interpretations-ams-data','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22680098-fermi-lat-kills-dark-matter-interpretations-ams-data"><span>Fermi-<span class="hlt">LAT</span> kills dark matter interpretations of AMS-02 data. Or not?</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Belotsky, Konstantin; Budaev, Ruslan; Kirillov, Alexander</p> <p>2017-01-01</p> <p>A number of papers attempt to explain the positron anomaly in cosmic rays, observed by PAMELA and AMS-02, in terms of dark matter (DM) decays or annihilations. However, the recent progress in cosmic gamma-ray studies challenges these attempts. Indeed, as we show, any rational DM model explaining the positron anomaly abundantly produces final state radiation and Inverse Compton gamma rays, which inevitably leads to a contradiction with Fermi-<span class="hlt">LAT</span> isotropic diffuse gamma-ray background measurements. Furthermore, the Fermi-<span class="hlt">LAT</span> observation of Milky Way dwarf satellites, supposed to be rich in DM, revealed no significant signal in gamma rays. We propose a generic approachmore » in which the major contribution to cosmic rays comes from the dark matter disc and prove that the tension between the DM origin of the positron anomaly and the cosmic gamma-ray observations can be relieved. We consider both a simple model, in which DM decay/annihilate into charged leptons, and a model-independent minimal case of particle production, and we estimate the optimal thickness of DM disk. Possible mechanisms of formation and its properties are briefly discussed.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22525000-limits-dark-matter-annihilation-cross-section-from-combined-analysis-magic-fermi-lat-observations-dwarf-satellite-galaxies','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22525000-limits-dark-matter-annihilation-cross-section-from-combined-analysis-magic-fermi-lat-observations-dwarf-satellite-galaxies"><span>Limits to dark matter annihilation cross-section from a combined analysis of MAGIC and Fermi-<span class="hlt">LAT</span> observations of dwarf satellite galaxies</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>MAGIC Collaboration</p> <p>2016-02-01</p> <p>We present the first joint analysis of gamma-ray data from the MAGIC Cherenkov telescopes and the Fermi Large Area Telescope (<span class="hlt">LAT</span>) to search for gamma-ray signals from dark matter annihilation in dwarf satellite galaxies. We combine 158 hours of Segue 1 observations with MAGIC with 6-year observations of 15 dwarf satellite galaxies by the Fermi-<span class="hlt">LAT</span>. We obtain limits on the annihilation cross-section for dark matter particle masses between 10 GeV and 100 TeV—the widest mass range ever explored by a single gamma-ray analysis. These limits improve on previously published Fermi-<span class="hlt">LAT</span> and MAGIC results by up to a factor of twomore » at certain masses. Our new inclusive analysis approach is completely generic and can be used to perform a global, sensitivity-optimized dark matter search by combining data from present and future gamma-ray and neutrino detectors.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016JCAP...02..039M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016JCAP...02..039M"><span>Limits to dark matter annihilation cross-section from a combined analysis of MAGIC and Fermi-<span class="hlt">LAT</span> observations of dwarf satellite galaxies</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>MAGIC Collaboration; Ahnen, M. L.; Ansoldi, S.; Antonelli, L. A.; Antoranz, P.; Babic, A.; Banerjee, B.; Bangale, P.; Barres de Almeida, U.; Barrio, J. A.; Becerra González, J.; Bednarek, W.; Bernardini, E.; Biasuzzi, B.; Biland, A.; Blanch, O.; Bonnefoy, S.; Bonnoli, G.; Borracci, F.; Bretz, T.; Carmona, E.; Carosi, A.; Chatterjee, A.; Clavero, R.; Colin, P.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; Da Vela, P.; Dazzi, F.; De Angelis, A.; De Lotto, B.; de Oña Wilhelmi, E.; Delgado Mendez, C.; Di Pierro, F.; Dominis Prester, D.; Dorner, D.; Doro, M.; Einecke, S.; Eisenacher Glawion, D.; Elsaesser, D.; Fernández-Barral, A.; Fidalgo, D.; Fonseca, M. V.; Font, L.; Frantzen, K.; Fruck, C.; Galindo, D.; García López, R. J.; Garczarczyk, M.; Garrido Terrats, D.; Gaug, M.; Giammaria, P.; Godinović, N.; González Muñoz,; A.; Guberman, D.; Hahn, A.; Hanabata, Y.; Hayashida, M.; Herrera, J.; Hose, J.; Hrupec, D.; Hughes, G.; Idec, W.; Kodani, K.; Konno, Y.; Kubo, H.; Kushida, J.; La Barbera, A.; Lelas, D.; Lindfors, E.; Lombardi, S.; Longo, F.; López-Coto, M. López R.; López-Oramas, A.; Lorenz, E.; Majumdar, P.; Makariev, M.; Mallot, K.; Maneva, G.; Manganaro, M.; Mannheim, K.; Maraschi, L.; Marcote, B.; Mariotti, M.; Martínez, M.; Mazin, D.; Menzel, U.; Miranda, J. M.; Mirzoyan, R.; Moralejo, A.; Moretti, E.; Nakajima, D.; Neustroev, V.; Niedzwiecki, A.; Nievas Rosillo, M.; Nilsson, K.; Nishijima, K.; Noda, K.; Orito, R.; Overkemping, A.; Paiano, S.; Palacio, J.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Paredes-Fortuny, X.; Persic, M.; Poutanen, J.; Prada Moroni, P. G.; Prandini, E.; Puljak, I.; Rhode, W.; Ribó, M.; Rico, J.; Rodriguez Garcia, J.; Saito, T.; Satalecka, K.; Schultz, C.; Schweizer, T.; Shore, S. N.; Sillanpää, A.; Sitarek, J.; Snidaric, I.; Sobczynska, D.; Stamerra, A.; Steinbring, T.; Strzys, M.; Takalo, L.; Takami, H.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Tescaro, D.; Teshima, M.; Thaele, J.; Torres, D. F.; Toyama, T.; Treves, A.; Verguilov, V.; Vovk, I.; Ward, J. E.; Will, M.; Wup, M. H.; Zanins, R.; Aleksić, J.; Wood, M.; Anderson, B.; Bloom, E. D.; Cohen-Tanugi, J.; Drlica-Wagner, A.; Mazziotta, M. N.; Sánchez-Condeai, M.; Strigarian, L.</p> <p>2016-02-01</p> <p>We present the first joint analysis of gamma-ray data from the MAGIC Cherenkov telescopes and the Fermi Large Area Telescope (<span class="hlt">LAT</span>) to search for gamma-ray signals from dark matter annihilation in dwarf satellite galaxies. We combine 158 hours of Segue 1 observations with MAGIC with 6-year observations of 15 dwarf satellite galaxies by the Fermi-<span class="hlt">LAT</span>. We obtain limits on the annihilation cross-section for dark matter particle masses between 10 GeV and 100 TeV—the widest mass range ever explored by a single gamma-ray analysis. These limits improve on previously published Fermi-<span class="hlt">LAT</span> and MAGIC results by up to a factor of two at certain masses. Our new inclusive analysis approach is completely generic and can be used to perform a global, sensitivity-optimized dark matter search by combining data from present and future gamma-ray and neutrino detectors.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28709952','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28709952"><span>Potent inhibitors of human <span class="hlt">LAT</span>1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Napolitano, Lara; Scalise, Mariafrancesca; Koyioni, Maria; Koutentis, Panayiotis; Catto, Marco; Eberini, Ivano; Parravicini, Chiara; Palazzolo, Luca; Pisani, Leonardo; Galluccio, Michele; Console, Lara; Carotti, Angelo; Indiveri, Cesare</p> <p>2017-11-01</p> <p>The <span class="hlt">LAT</span>1 transporter is acknowledged as a pharmacological target of tumours since it is strongly overexpressed in many human cancers. The purpose of this work was to find novel compounds exhibiting potent and prolonged inhibition of the transporter. To this aim, compounds based on dithiazole and dithiazine scaffold have been screened in the proteoliposome experimental model. Inhibition was tested on the antiport catalysed by h<span class="hlt">LAT</span>1 as transport of extraliposomal [ 3 H]histidine in exchange with intraliposomal histidine. Out of 59 compounds tested, 8 compounds, showing an inhibition higher than 90% at 100µM concentration, were subjected to dose-response analysis. Two of them exhibited IC 50 lower than 1µM. Inhibition kinetics, performed on the two best inhibitors, indicated a mixed type of inhibition with respect to the substrate. Furthermore, inhibition of the transporter was still present after removal of the compounds from the reaction mixture, but was reversed on addition of dithioerythritol, a S-S reducing agent, indicating the formation of disulfide(s) between the compounds and the protein. Molecular docking of the two best inhibitors on the h<span class="hlt">LAT</span>1 homology structural model, highlighted interaction with the substrate binding site and formation of a covalent bond with the residue C407. Indeed, the inhibition was impaired in the h<span class="hlt">LAT</span>1 mutant C407A confirming the involvement of that Cys residue. Treatment of SiHa cells expressing h<span class="hlt">LAT</span>1 at relatively high level, with the two most potent inhibitors led to cell death which was not observed after treatment with a compound exhibiting very poor inhibitory effect. Copyright © 2017 Elsevier Inc. All rights reserved.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_19 --> <div id="page_20" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="381"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21993757','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21993757"><span>Coherent coupling of a superconducting <span class="hlt">flux</span> qubit to an <span class="hlt">electron</span> spin ensemble in diamond.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Zhu, Xiaobo; Saito, Shiro; Kemp, Alexander; Kakuyanagi, Kosuke; Karimoto, Shin-ichi; Nakano, Hayato; Munro, William J; Tokura, Yasuhiro; Everitt, Mark S; Nemoto, Kae; Kasu, Makoto; Mizuochi, Norikazu; Semba, Kouichi</p> <p>2011-10-12</p> <p>During the past decade, research into superconducting quantum bits (qubits) based on Josephson junctions has made rapid progress. Many foundational experiments have been performed, and superconducting qubits are now considered one of the most promising systems for quantum information processing. However, the experimentally reported coherence times are likely to be insufficient for future large-scale quantum computation. A natural solution to this problem is a dedicated engineered quantum memory based on atomic and molecular systems. The question of whether coherent quantum coupling is possible between such natural systems and a single macroscopic artificial atom has attracted considerable attention since the first demonstration of macroscopic quantum coherence in Josephson junction circuits. Here we report evidence of coherent strong coupling between a single macroscopic superconducting artificial atom (a <span class="hlt">flux</span> qubit) and an ensemble of <span class="hlt">electron</span> spins in the form of nitrogen-vacancy colour centres in diamond. Furthermore, we have observed coherent exchange of a single quantum of energy between a <span class="hlt">flux</span> qubit and a macroscopic ensemble consisting of about 3 × 10(7) such colour centres. This provides a foundation for future quantum memories and hybrid devices coupling microwave and optical systems.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005AGUFMSM41A1175K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005AGUFMSM41A1175K"><span>Precipitated <span class="hlt">Fluxes</span> of Radiation Belt <span class="hlt">Electrons</span> via Injection of Whistler-Mode Waves</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kulkarni, P.; Inan, U. S.; Bell, T. F.</p> <p>2005-12-01</p> <p>Inan et al. (U.S. Inan et al., Controlled precipitation of radiation belt <span class="hlt">electrons</span>, Journal of Geophysical Research-Space Physics, 108 (A5), 1186, doi: 10.1029/2002JA009580, 2003.) suggested that the lifetime of energetic (a few MeV) <span class="hlt">electrons</span> in the inner radiation belts may be moderated by in situ injection of whistler mode waves at frequencies of a few kHz. We use the Stanford 2D VLF raytracing program (along with an accurate estimation of the path-integrated Landau damping based on data from the HYDRA instrument on the POLAR spacecraft) to determine the distribution of wave energy throughout the inner radiation belts as a function of injection point, wave frequency and injection wave normal angle. To determine the total wave power injected and its initial distribution in k-space (i.e., wave-normal angle), we apply the formulation of Wang and Bell ( T.N.C. Wang and T.F. Bell, Radiation resistance of a short dipole immersed in a cold magnetoionic medium, Radio Science, 4 (2), 167-177, February 1969) for an electric dipole antenna placed at a variety of locations throughout the inner radiation belts. For many wave frequencies and wave normal angles the results establish that most of the radiated power is concentrated in waves whose wave normals are located near the resonance cone. The combined use of the radiation pattern and ray-tracing including Landau damping allows us to make quantitative estimates of the magnetospheric distribution of wave power density for different source injection points. We use these results to estimate the number of individual space-based transmitters needed to significantly impact the lifetimes of energetic <span class="hlt">electrons</span> in the inner radiation belts. Using the wave power distribution, we finally determine the energetic <span class="hlt">electron</span> pitch angle scattering and the precipitated <span class="hlt">flux</span> signatures that would be detected.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title50-vol9/pdf/CFR-2010-title50-vol9-part660-app3.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title50-vol9/pdf/CFR-2010-title50-vol9-part660-app3.pdf"><span>50 CFR Table 3 (north) to Part 660... - 2010 Trip Limits for Open Access Gears North of 40°10′ N. <span class="hlt">Lat</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false 2010 Trip Limits for Open Access Gears North of 40°10â² N. <span class="hlt">Lat</span>. 3 Table 3 (North) to Part 660, Subpart F Wildlife and Fisheries FISHERY... Limits for Open Access Gears North of 40°10′ N. <span class="hlt">Lat</span>. ER01OC10.020 ER01OC10.021 ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title50-vol9/pdf/CFR-2010-title50-vol9-part660-app3-id77.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title50-vol9/pdf/CFR-2010-title50-vol9-part660-app3-id77.pdf"><span>50 CFR Table 3 (south) to Part 660... - 2010 Trip Limits for Open Access Gears South of 40°10′ N. <span class="hlt">Lat</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false 2010 Trip Limits for Open Access Gears South of 40°10â² N. <span class="hlt">Lat</span>. 3 Table 3 (South) to Part 660, Subpart F Wildlife and Fisheries FISHERY... Limits for Open Access Gears South of 40°10′ N. <span class="hlt">Lat</span>. ER01OC10.022 ER01OC10.023 ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013JGRA..118.7810R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013JGRA..118.7810R"><span>Comparison between POES energetic <span class="hlt">electron</span> precipitation observations and riometer absorptions: Implications for determining true precipitation <span class="hlt">fluxes</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Rodger, Craig J.; Kavanagh, Andrew J.; Clilverd, Mark A.; Marple, Steve R.</p> <p>2013-12-01</p> <p><span class="hlt">electron</span> precipitation (EEP) impacts the chemistry of the middle atmosphere with growing evidence of coupling to surface temperatures at high latitudes. To better understand this link, it is essential to have realistic observations to properly characterize precipitation and which can be incorporated into chemistry-climate models. The Polar-orbiting Operational Environmental Satellite (POES) detectors measure precipitating particles but only integral <span class="hlt">fluxes</span> and only in a fraction of the bounce loss cone. Ground-based riometers respond to precipitation from the whole bounce loss cone; they measure the cosmic radio noise absorption (CNA), a qualitative proxy with scant direct information on the energy <span class="hlt">flux</span> of EEP. POES observations should have a direct relationship with ΔCNA and comparing the two will clarify their utility in studies of atmospheric change. We determined ionospheric changes produced by the EEP measured by the POES spacecraft in ~250 overpasses of an imaging riometer in northern Finland. The ΔCNA modeled from the POES data is 10-15 times less than the observed ΔCNA when the >30 keV <span class="hlt">flux</span> is reported as <106 cm-2 s-1 sr-1. Above this level, there is relatively good agreement between the space-based and ground-based measurements. The discrepancy occurs mostly during periods of low geomagnetic activity, and we contend that weak diffusion is dominating the pitch angle scattering into the bounce loss cone at these times. A correction to the calculation using measurements of the trapped <span class="hlt">flux</span> considerably reduces the discrepancy and provides further support to our hypothesis that weak diffusion leads to underestimates of the EEP.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/24841118','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/24841118"><span>Insights into <span class="hlt">electron</span> <span class="hlt">flux</span> through manipulation of fermentation conditions and assessment of protein expression profiles in Clostridium thermocellum.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rydzak, Thomas; Grigoryan, Marina; Cunningham, Zack J; Krokhin, Oleg V; Ezzati, Peyman; Cicek, Nazim; Levin, David B; Wilkins, John A; Sparling, Richard</p> <p>2014-01-01</p> <p>While annotation of the genome sequence of Clostridium thermocellum has allowed predictions of pathways catabolizing cellobiose to end products, ambiguities have persisted with respect to the role of various proteins involved in <span class="hlt">electron</span> transfer reactions. A combination of growth studies modulating carbon and <span class="hlt">electron</span> flow and multiple reaction monitoring (MRM) mass spectrometry measurements of proteins involved in central metabolism and <span class="hlt">electron</span> transfer was used to determine the key enzymes involved in channeling <span class="hlt">electrons</span> toward fermentation end products. Specifically, peptides belonging to subunits of ferredoxin-dependent hydrogenase and NADH:ferredoxin oxidoreductase (NFOR) were low or below MRM detection limits when compared to most central metabolic proteins measured. The significant increase in H2 versus ethanol synthesis in response to either co-metabolism of pyruvate and cellobiose or hypophosphite mediated pyruvate:formate lyase inhibition, in conjunction with low levels of ferredoxin-dependent hydrogenase and NFOR, suggest that highly expressed putative bifurcating hydrogenases play a substantial role in reoxidizing both reduced ferredoxin and NADH simultaneously. However, product balances also suggest that some of the additional reduced ferredoxin generated through increased <span class="hlt">flux</span> through pyruvate:ferredoxin oxidoreductase must be ultimately converted into NAD(P)H either directly via NADH-dependent reduced ferredoxin:NADP(+) oxidoreductase (NfnAB) or indirectly via NADPH-dependent hydrogenase. While inhibition of hydrogenases with carbon monoxide decreased H2 production 6-fold and redirected <span class="hlt">flux</span> from pyruvate:ferredoxin oxidoreductase to pyruvate:formate lyase, the decrease in CO2 was only 20 % of that of the decrease in H2, further suggesting that an alternative redox system coupling ferredoxin and NAD(P)H is active in C. thermocellum in lieu of poorly expressed ferredoxin-dependent hydrogenase and NFOR.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20000004926','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20000004926"><span>Crres Observations of Particle <span class="hlt">Flux</span> Dropout Events</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Fennell, J.; Roeder, J.; Spence, H.; Singer, H.; Korth, A.; Grande, M.; Vampola, A.</p> <p>1999-01-01</p> <p>The complete disappearance of energetic <span class="hlt">electrons</span> was observed by CRRES in the near geosynchronous region in 7.5% of the orbits examined. These total <span class="hlt">flux</span> dropouts were defined by the <span class="hlt">fluxes</span> rapidly dropping to levels below the sensitivity of the MEA energetic <span class="hlt">electron</span> spectrometer on the CRRES satellite. They were separated into those that were only energetic <span class="hlt">electron</span> dropouts and those that were associated with energetic ion and plasma dropouts. Approximately 20% of the events showed dropouts of 0 particle <span class="hlt">fluxes</span>, and these were usually coincident with large increases in the local magnetic intensity and signatures of strong current systems. The energetic particle instruments and magnetometer on CRRES provide a detailed picture of the particle and field responses to these unusual conditions. Both the local morning and dusk events were associated with strong azimuthal (eastward) and radial changes in the magnetic field indicative of a strong current system approaching and sometimes crossing the CRRES position at the time of the <span class="hlt">flux</span> dropouts. The direction of the field changes and the details of particle observations are consistent with CRRES passing through the plasma sheet boundary layer and entering the tail lobe for a significant number of the events.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22127011-bidirectional-fluxes-nearly-relativistic-electrons-during-onset-solar-energetic-particle-events','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22127011-bidirectional-fluxes-nearly-relativistic-electrons-during-onset-solar-energetic-particle-events"><span>BIDIRECTIONAL <span class="hlt">FLUXES</span> OF NEARLY RELATIVISTIC <span class="hlt">ELECTRONS</span> DURING THE ONSET OF SOLAR ENERGETIC PARTICLE EVENTS</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Sun, L. P.; Li, C., E-mail: pmo_sunlp@msn.com</p> <p>2013-03-10</p> <p>We report intensity and anisotropy measurements of energetic <span class="hlt">electrons</span> in the energy range of {approx}27-{approx}500 keV as observed with the Wind and Advanced Composition Explorer (ACE) spacecraft in 2000 June for several solar energetic particle (SEP) events. The solar sources of the SEP events are inferred from observations from the Solar and Heliospheric Observatory spacecraft. All of the events originate from the western limb active regions (ARs), which are well connected by interplanetary magnetic field (IMF) lines linking the Sun to near-Earth space. The observations on board Wind show bimodal pitch angle distributions (PADs), whereas ACE shows PADs with onemore » peak, as is usually observed for impulsive injection of <span class="hlt">electrons</span> at the Sun. During the time of observations, Wind was located, upstream of the Earth's bow shock in the dawn-noon sector, at distances of {approx}40-{approx}80 R{sub E} from the Earth, and we infer that it was magnetically connected to the quasi-parallel bow shock. Meanwhile, ACE, orbiting the Sun-Earth libration point L1, was not connected to the bow shock. The <span class="hlt">electron</span> intensity-time profiles and the energy spectra show that the backstreaming <span class="hlt">electrons</span> observed at Wind are not of magnetospheric origin. The observations suggest rather that the bidirectional <span class="hlt">electron</span> <span class="hlt">fluxes</span> are due to reflection or scattering by an obstacle located at a distance of less than {approx}150 R{sub E} in the anti-sunward direction, which is compatible with the obstacle being the Earth's bow shock or magnetosheath.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://eric.ed.gov/?q=dream+AND+act&pg=4&id=ED514754','ERIC'); return false;" href="https://eric.ed.gov/?q=dream+AND+act&pg=4&id=ED514754"><span>Suenos Indocumentados: Using <span class="hlt">Lat</span>Crit to Explore the Testimonios of Undocumented and U.S. Born Chicana College Students on Discourses of Racist Nativism in Education</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Huber, Lindsay Perez</p> <p>2010-01-01</p> <p>Latina/o critical race theory (<span class="hlt">Lat</span>Crit) is used as an overarching framework that examines the intersectionality of race, class, and gender while also acknowledging the unique forms of subordination within the Latina/o community based on immigration status, language, phenotype, and ethnicity. <span class="hlt">Lat</span>Crit allows for the specific examination of race and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=208374','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=208374"><span>Localization of the lysine epsilon-aminotransferase (<span class="hlt">lat</span>) and delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase (pcbAB) genes from Streptomyces clavuligerus and production of lysine epsilon-aminotransferase activity in Escherichia coli.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Tobin, M B; Kovacevic, S; Madduri, K; Hoskins, J A; Skatrud, P L; Vining, L C; Stuttard, C; Miller, J R</p> <p>1991-01-01</p> <p>Lysine epsilon-aminotransferase (<span class="hlt">LAT</span>) in the beta-lactam-producing actinomycetes is considered to be the first step in the antibiotic biosynthetic pathway. Cloning of restriction fragments from Streptomyces clavuligerus, a beta-lactam producer, into Streptomyces lividans, a nonproducer that lacks <span class="hlt">LAT</span> activity, led to the production of <span class="hlt">LAT</span> in the host. DNA sequencing of restriction fragments containing the putative <span class="hlt">lat</span> gene revealed a single open reading frame encoding a polypeptide with an approximately Mr 49,000. Expression of this coding sequence in Escherichia coli led to the production of <span class="hlt">LAT</span> activity. Hence, <span class="hlt">LAT</span> activity in S. clavuligerus is derived from a single polypeptide. A second open reading frame began immediately downstream from <span class="hlt">lat</span>. Comparison of this partial sequence with the sequences of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D valine (ACV) synthetases from Penicillium chrysogenum and Cephalosporium acremonium and with nonribosomal peptide synthetases (gramicidin S and tyrocidine synthetases) found similarities among the open reading frames. Since mapping of the putative N and C termini of S. clavuligerus pcbAB suggests that the coding region occupies approximately 12 kbp and codes for a polypeptide related in size to the fungal ACV synthetases, the molecular characterization of the beta-lactam biosynthetic cluster between pcbC and cefE (approximately 25 kbp) is nearly complete. Images PMID:1917855</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018AAS...23133005R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018AAS...23133005R"><span>Probing the debris disks of nearby stars with Fermi-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Riley, Alexander; Strigari, Louis; Porter, Troy; Blandford, Roger</p> <p>2018-01-01</p> <p>Many nearby stars are known to host circumstellar debris disks, similar to our Sun's asteroid and Kuiper belts, that are believed to be the birthplace of extrasolar planets. The bodies in these objects passively emit gamma radiation resulting from interactions with cosmic rays, as previously observed from measurements of the gamma ray albedo of the Moon. We apply a point source analysis to four nearby debris disks using the past nine years of data taken by Fermi-<span class="hlt">LAT</span>, and report on the updated prospects for detecting gamma-ray emission from these sources.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1275501-limits-dark-matter-annihilation-cross-section-from-combined-analysis-magic-fermi-lat-observations-dwarf-satellite-galaxies','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1275501-limits-dark-matter-annihilation-cross-section-from-combined-analysis-magic-fermi-lat-observations-dwarf-satellite-galaxies"><span>Limits to dark matter annihilation cross-section from a combined analysis of MAGIC and Fermi-<span class="hlt">LAT</span> observations of dwarf satellite galaxies</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Ahnen, M. L.</p> <p>2016-02-16</p> <p>Here, we present the first joint analysis of gamma-ray data from the MAGIC Cherenkov telescopes and the Fermi Large Area Telescope (<span class="hlt">LAT</span>) to search for gamma-ray signals from dark matter annihilation in dwarf satellite galaxies. We combine 158 hours of Segue 1 observations with MAGIC with 6-year observations of 15 dwarf satellite galaxies by the Fermi-<span class="hlt">LAT</span>. We obtain limits on the annihilation cross-section for dark matter particle masses between 10 GeV and 100 TeV - the widest mass range ever explored by a single gamma-ray analysis. These limits improve on previously published Fermi-<span class="hlt">LAT</span> and MAGIC results by up to amore » factor of two at certain masses. Our new inclusive analysis approach is completely generic and can be used to perform a global, sensitivity-optimized dark matter search by combining data from present and future gamma-ray and neutrino detectors.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014ATel.6085....1B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014ATel.6085....1B"><span>Fermi <span class="hlt">LAT</span> detection of increased gamma-ray activity from blazar S5 0716+71</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Buson, S.</p> <p>2014-04-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), one of two instruments on-board the Fermi Gamma-ray Space Telescope, has observed an increase in gamma-ray activity from a source positionally coincident with the BL Lac object S5 0716+71 (also known as 2FGL J0721.9+7120, Nolan et al. ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19950045515&hterms=lanchester&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dlanchester','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19950045515&hterms=lanchester&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Dlanchester"><span>Energy <span class="hlt">flux</span> and characteristic energy of an elemental auroral structure</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Lanchester, B. S.; Palmer, J. R.; Rees, M. H.; Lummerzheim, D.; Kaila, K.; Turunen, T.</p> <p>1994-01-01</p> <p><span class="hlt">Electron</span> density profiles acquired with the EISCAT radar at 0.2 s time resolution, together with TV images and photometric intensities, were used to study the characteristics of thin (less than 1 km) auroral arc structures that drifted through the field of view of the instruments. It is demonstrated that both high time and space resolution are essential for deriving the input parameters of the <span class="hlt">electron</span> <span class="hlt">flux</span> responsible for the elemental auroral structures. One such structure required a 400 mW/sq m (erg/sq cm s) downward energy <span class="hlt">flux</span> carried by an 8 keV monochromatic <span class="hlt">electron</span> <span class="hlt">flux</span> equivalent to a current density of 50 micro Angstrom/sq m.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFMSH13C2488V','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFMSH13C2488V"><span>Measurements of the Canonical Helicity Evolution of a Gyrating Kinked <span class="hlt">Flux</span> Rope</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>von der Linden, J.; Sears, J.; Intrator, T.; You, S.</p> <p>2017-12-01</p> <p>Magnetic structures in the solar corona and planetary magnetospheres are often modelled as magnetic <span class="hlt">flux</span> ropes governed by magnetohydrodynamics (MHD); however, inside these structures, as exhibited in reconnection, conversions between magnetic and kinetic energies occur over a wide range of scales. <span class="hlt">Flux</span> ropes based on the <span class="hlt">flux</span> of canonical momentum circulation extend the <span class="hlt">flux</span> rope concept to include effects of finite particle momentum and present the distinct advantage of reconciling all plasma regimes - e.g. kinetic, two-fluid, and MHD - with the topological concept of helicity: twists, writhes, and linkages. This presentation shows the first visualization and analysis of the 3D dynamics of canonical <span class="hlt">flux</span> ropes and their relative helicity evolution from laboratory measurements. Ion and <span class="hlt">electron</span> canonical <span class="hlt">flux</span> ropes are visualized from a dataset of Mach, triple, and Ḃ probe measurements at over 10,000 spatial locations of a gyrating kinked <span class="hlt">flux</span> rope. The <span class="hlt">flux</span> ropes co-gyrate with the peak density and <span class="hlt">electron</span> temperature in and out of a measurement volume. The <span class="hlt">electron</span> and ion canonical <span class="hlt">flux</span> ropes twist with opposite handedness and the ion <span class="hlt">flux</span> ropes writhe around the <span class="hlt">electron</span> <span class="hlt">flux</span> ropes. The relative cross helicity between the magnetic and ion flow vorticity <span class="hlt">flux</span> ropes dominates the relative ion canonical helicity and is anti-correlated with the relative magnetic helicity. The 3D nature of the kink and a reverse eddy current affect the helicity evolution. This work is supported by DOE Grant DE-SC0010340 and the DOE Office of Science Graduate Student Research Program and prepared in part by LLNL under Contract DE-AC52-07NA27344. LLNL-ABS-735426</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1353465-constraints-neutrino-flux-nova-using-near-detector-data','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1353465-constraints-neutrino-flux-nova-using-near-detector-data"><span>Constraints on the neutrino <span class="hlt">flux</span> in NOvA using the near detector data</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Maan, Kuldeep K.</p> <p>2016-12-19</p> <p>NOvA, a long-baseline neutrino oscillation experiment at Fermilab, is designed to measure <span class="hlt">electron</span>-neutrino appearance and muon-neutrino disappearance in the NuMI beam. NOvA comprises of two finely segmented liquid scintillator detectors at 14 mrad off-axis in the NuMI beam. An accurate prediction of the neutrino <span class="hlt">flux</span> is needed for precision oscillation and cross-section measurements. Data from the hadron-production experiments and, importantly, from the NOvA Near Detector provide powerful constraints on the muon-neutrino and <span class="hlt">electron</span>-neutrino <span class="hlt">fluxes</span>. In particular, the measurement of the neutrino-<span class="hlt">electron</span> elastic scattering provides an in situ constraint on the absolute <span class="hlt">flux</span>. Lastly, this poster presents the data-driven predictions ofmore » the NOvA muonneutrino and <span class="hlt">electron</span>-neutrino <span class="hlt">flux</span>, and outlines future improvements in the <span class="hlt">flux</span> determination.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1354932','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1354932"><span>Rapid variability of blazar 3C 279 during flaring states in 2013-2014 with joint FERMI-<span class="hlt">LAT</span>, NuSTAR, SWIFT, and ground-based multi-wavelength observations</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Hayashida, M.; Nalewajko, K.; Madejski, G. M.</p> <p>2015-07-02</p> <p>Here we report the results of a multiband observing campaign on the famous blazar 3C 279 conducted during a phase of increased activity from 2013 December to 2014 April, including first observations of it with NuSTAR. The γ-ray emission of the source measured by Fermi-<span class="hlt">LAT</span> showed multiple distinct flares reaching the highest <span class="hlt">flux</span> level measured in this object since the beginning of the Fermi mission, with F(E>100 MeV) of 10 -5 photons cm -2 s -1, and with a <span class="hlt">flux</span>-doubling time scale as short as 2 hr. The γ-ray spectrum during one of the flares was very hard, with an index of Γ γ =1.7±0.1, which is rarely seen in flat-spectrum radio quasars. The lack of concurrent optical variability implies a very high Compton dominance parameter L γ/L syn > 300. Two 1 day NuSTAR observations with accompanying Swift pointings were separated by 2 weeks, probing different levels of source activity. While the 0.5-70 keV X-ray spectrum obtained during the first pointing, and fitted jointly with Swift-XRT is well-described by a simple power law, the second joint observation showed an unusual spectral structure: the spectrum softens by ΔΓ xmore » $$\\simeq$$ 0.4 at ~ keV. Modeling the broadband spectral energy distribution during this flare with the standard synchrotron plus inverse-Compton model requires: (1) the location of the γ-ray emitting region is comparable with the broad-line region radius, (2) a very hard <span class="hlt">electron</span> energy distribution index p $$\\simeq$$ 1, (3) total jet power significantly exceeding the accretion-disk luminosity L j/L d ≳ 10, and (4) extremely low jet magnetization with L B/L j ≲ 10 -4. In conclusion, we also find that single-zone models that match the observed γ-ray and optical spectra cannot satisfactorily explain the production of X-ray emission.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/6481619-some-results-radiation-belt-electrons-from-observations-satellite-borne-semiconductor-electron-detector','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/6481619-some-results-radiation-belt-electrons-from-observations-satellite-borne-semiconductor-electron-detector"><span>Some results on radiation belt <span class="hlt">electrons</span> from observations of satellite-borne semiconductor <span class="hlt">electron</span> detector</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Cheng Doug-yuan; Wu Ji-ping</p> <p>1987-04-01</p> <p>This paper presents some results from observations of a Chinese satellite-borne semiconductor <span class="hlt">electron</span> detector. Data analysis yields typical values of <span class="hlt">electron</span> <span class="hlt">fluxes</span> in the central region of the inner radiation belt. The omnidirectional <span class="hlt">fluxes</span> of <span class="hlt">electrons</span> having energies greater than 0.5 MeV and 1.0 MeV are 1.9 x 10/sup 8/ and 6.7 x 10/sup 7/ elec./s-cm/sup 2/, respectively. The <span class="hlt">electron-flux</span> profile on a typical orbit as a function of time is also given. In addition, the omnidirectional <span class="hlt">fluxes</span> at the synchronous altitude for the two <span class="hlt">electron</span>-energy levels mentioned are 2.43 x 10/sup 6/ and 4.25 x 10/sup 5/ elec./s-cm/sup 2/.more » The diurnal variations of <span class="hlt">electrons</span> in the outer radiation belt observed at the synchronous altitude are also given. The results agree with those observed abroad.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22679714-multiple-wavelength-variability-quasi-periodic-oscillation-pmn-j0948+0022','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22679714-multiple-wavelength-variability-quasi-periodic-oscillation-pmn-j0948+0022"><span>Multiple-wavelength Variability and Quasi-periodic Oscillation of PMN J0948+0022</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Zhang, Jin; Zhang, Hai-Ming; Zhu, Yong-Kai</p> <p></p> <p>We present a comprehensive analysis of multiple-wavelength observational data of the first GeV-selected narrow-line Seyfert 1 galaxy PMN J0948+0022. We derive its light curves in the γ -ray and X-ray bands from the data observed with Fermi /<span class="hlt">LAT</span> and Swift /XRT, and generate the optical and radio light curves by collecting the data from the literature. These light curves show significant <span class="hlt">flux</span> variations. With the <span class="hlt">LAT</span> data we show that this source is analogous to typical flat spectrum radio quasars in the L {sub γ} –Γ {sub γ} plane, where L {sub γ} and Γ {sub γ} are the luminositymore » and spectral index in the <span class="hlt">LAT</span> energy band. The γ -ray <span class="hlt">flux</span> is correlated with the V-band <span class="hlt">flux</span> with a lag of ∼44 days, and a moderate quasi-periodic oscillation (QPO) with a periodicity of ∼490 days observed in the <span class="hlt">LAT</span> light curve. A similar QPO signature is also found in the V-band light curve. The γ -ray <span class="hlt">flux</span> is not correlated with the radio <span class="hlt">flux</span> in 15 GHz, and no similar QPO signature is found at a confidence level of 95%. Possible mechanisms of the QPO are discussed. We propose that gravitational-wave observations in the future may clarify the current plausible models for the QPO.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1379525-phosphotyrosine-mediated-lat-assembly-membranes-drives-kinetic-bifurcation-recruitment-dynamics-ras-activator-sos','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1379525-phosphotyrosine-mediated-lat-assembly-membranes-drives-kinetic-bifurcation-recruitment-dynamics-ras-activator-sos"><span>Phosphotyrosine-mediated <span class="hlt">LAT</span> assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Huang, William Y. C.; Yan, Qingrong; Lin, Wan-Chen; ...</p> <p>2016-07-01</p> <p>The assembly of cell surface receptors with downstream signaling molecules is a commonly occurring theme in multiple signaling systems. However, little is known about how these assemblies modulate reaction kinetics and the ultimate propagation of signals. Here, we reconstitute phosphotyrosine-mediated assembly of extended linker for the activation of T cells (<span class="hlt">LAT</span>):growth factor receptor-bound protein 2 (Grb2):Son of Sevenless (SOS) networks, derived from the T-cell receptor signaling system, on supported membranes. Single-molecule dwell time distributions reveal two, well-differentiated kinetic species for both Grb2 and SOS on the <span class="hlt">LAT</span> assemblies. The majority fraction of membrane-recruited Grb2 and SOS both exhibit fast kineticsmore » and single exponential dwell time distributions, with average dwell times of hundreds of milliseconds. The minor fraction exhibits much slower kinetics, extending the dwell times to tens of seconds. Considering this result in the context of the multistep process by which the Ras GEF (guanine nucleotide exchange factor) activity of SOS is activated indicates that kinetic stabilization from the <span class="hlt">LAT</span> assembly may be important. This kinetic proofreading effect would additionally serve as a stochastic noise filter by reducing the relative probability of spontaneous SOS activation in the absence of receptor triggering. In conclusion, the generality of receptor-mediated assembly suggests that such effects may play a role in multiple receptor proximal signaling processes.« less</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_20 --> <div id="page_21" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="401"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4961118','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4961118"><span>Phosphotyrosine-mediated <span class="hlt">LAT</span> assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Huang, William Y. C.; Yan, Qingrong; Lin, Wan-Chen; Chung, Jean K.; Hansen, Scott D.; Christensen, Sune M.; Tu, Hsiung-Lin; Kuriyan, John; Groves, Jay T.</p> <p>2016-01-01</p> <p>The assembly of cell surface receptors with downstream signaling molecules is a commonly occurring theme in multiple signaling systems. However, little is known about how these assemblies modulate reaction kinetics and the ultimate propagation of signals. Here, we reconstitute phosphotyrosine-mediated assembly of extended linker for the activation of T cells (<span class="hlt">LAT</span>):growth factor receptor-bound protein 2 (Grb2):Son of Sevenless (SOS) networks, derived from the T-cell receptor signaling system, on supported membranes. Single-molecule dwell time distributions reveal two, well-differentiated kinetic species for both Grb2 and SOS on the <span class="hlt">LAT</span> assemblies. The majority fraction of membrane-recruited Grb2 and SOS both exhibit fast kinetics and single exponential dwell time distributions, with average dwell times of hundreds of milliseconds. The minor fraction exhibits much slower kinetics, extending the dwell times to tens of seconds. Considering this result in the context of the multistep process by which the Ras GEF (guanine nucleotide exchange factor) activity of SOS is activated indicates that kinetic stabilization from the <span class="hlt">LAT</span> assembly may be important. This kinetic proofreading effect would additionally serve as a stochastic noise filter by reducing the relative probability of spontaneous SOS activation in the absence of receptor triggering. The generality of receptor-mediated assembly suggests that such effects may play a role in multiple receptor proximal signaling processes. PMID:27370798</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27370798','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27370798"><span>Phosphotyrosine-mediated <span class="hlt">LAT</span> assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Huang, William Y C; Yan, Qingrong; Lin, Wan-Chen; Chung, Jean K; Hansen, Scott D; Christensen, Sune M; Tu, Hsiung-Lin; Kuriyan, John; Groves, Jay T</p> <p>2016-07-19</p> <p>The assembly of cell surface receptors with downstream signaling molecules is a commonly occurring theme in multiple signaling systems. However, little is known about how these assemblies modulate reaction kinetics and the ultimate propagation of signals. Here, we reconstitute phosphotyrosine-mediated assembly of extended linker for the activation of T cells (<span class="hlt">LAT</span>):growth factor receptor-bound protein 2 (Grb2):Son of Sevenless (SOS) networks, derived from the T-cell receptor signaling system, on supported membranes. Single-molecule dwell time distributions reveal two, well-differentiated kinetic species for both Grb2 and SOS on the <span class="hlt">LAT</span> assemblies. The majority fraction of membrane-recruited Grb2 and SOS both exhibit fast kinetics and single exponential dwell time distributions, with average dwell times of hundreds of milliseconds. The minor fraction exhibits much slower kinetics, extending the dwell times to tens of seconds. Considering this result in the context of the multistep process by which the Ras GEF (guanine nucleotide exchange factor) activity of SOS is activated indicates that kinetic stabilization from the <span class="hlt">LAT</span> assembly may be important. This kinetic proofreading effect would additionally serve as a stochastic noise filter by reducing the relative probability of spontaneous SOS activation in the absence of receptor triggering. The generality of receptor-mediated assembly suggests that such effects may play a role in multiple receptor proximal signaling processes.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012ATel.4421....1O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012ATel.4421....1O"><span>Fermi <span class="hlt">LAT</span> detection of increase gamma-ray emission from OJ 248</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Orienti, M.; D'Ammando, F.</p> <p>2012-09-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), on board the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar OJ 248 (also known as 2FGL J0830.5+2407, Nolan et al. 2012, ApJS, 199, 31) with radio coordinates R.A.: 127.7170254 deg, Dec: 24.1832836 deg (J2000, Johnston et al. 1995, AJ, 110, 880) at redshift z=0.94 (Hewitt & Burbidge 1993, ApJS, 87, 451).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016PhRvL.117i1103A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016PhRvL.117i1103A"><span>Antiproton <span class="hlt">Flux</span>, Antiproton-to-Proton <span class="hlt">Flux</span> Ratio, and Properties of Elementary Particle <span class="hlt">Fluxes</span> in Primary Cosmic Rays Measured with the Alpha Magnetic Spectrometer on the International Space Station</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Aguilar, M.; Ali Cavasonza, L.; Alpat, B.; Ambrosi, G.; Arruda, L.; Attig, N.; Aupetit, S.; Azzarello, P.; Bachlechner, A.; Barao, F.; Barrau, A.; Barrin, L.; Bartoloni, A.; Basara, L.; Başeǧmez-du Pree, S.; Battarbee, M.; Battiston, R.; Bazo, J.; Becker, U.; Behlmann, M.; Beischer, B.; Berdugo, J.; Bertucci, B.; Bindi, V.; Boella, G.; de Boer, W.; Bollweg, K.; Bonnivard, V.; Borgia, B.; Boschini, M. J.; Bourquin, M.; Bueno, E. F.; Burger, J.; Cadoux, F.; Cai, X. D.; Capell, M.; Caroff, S.; Casaus, J.; Castellini, G.; Cernuda, I.; Cervelli, F.; Chae, M. J.; Chang, Y. H.; Chen, A. I.; Chen, G. M.; Chen, H. S.; Cheng, L.; Chou, H. Y.; Choumilov, E.; Choutko, V.; Chung, C. H.; Clark, C.; Clavero, R.; Coignet, G.; Consolandi, C.; Contin, A.; Corti, C.; Coste, B.; Creus, W.; Crispoltoni, M.; Cui, Z.; Dai, Y. M.; Delgado, C.; Della Torre, S.; Demirköz, M. B.; Derome, L.; Di Falco, S.; Dimiccoli, F.; Díaz, C.; von Doetinchem, P.; Dong, F.; Donnini, F.; Duranti, M.; D'Urso, D.; Egorov, A.; Eline, A.; Eronen, T.; Feng, J.; Fiandrini, E.; Finch, E.; Fisher, P.; Formato, V.; Galaktionov, Y.; Gallucci, G.; García, B.; García-López, R. J.; Gargiulo, C.; Gast, H.; Gebauer, I.; Gervasi, M.; Ghelfi, A.; Giovacchini, F.; Goglov, P.; Gómez-Coral, D. M.; Gong, J.; Goy, C.; Grabski, V.; Grandi, D.; Graziani, M.; Guerri, I.; Guo, K. H.; Habiby, M.; Haino, S.; Han, K. C.; He, Z. H.; Heil, M.; Hoffman, J.; Hsieh, T. H.; Huang, H.; Huang, Z. C.; Huh, C.; Incagli, M.; Ionica, M.; Jang, W. Y.; Jinchi, H.; Kang, S. C.; Kanishev, K.; Kim, G. N.; Kim, K. S.; Kirn, Th.; Konak, C.; Kounina, O.; Kounine, A.; Koutsenko, V.; Krafczyk, M. S.; La Vacca, G.; Laudi, E.; Laurenti, G.; Lazzizzera, I.; Lebedev, A.; Lee, H. T.; Lee, S. C.; Leluc, C.; Li, H. S.; Li, J. Q.; Li, J. Q.; Li, Q.; Li, T. X.; Li, W.; Li, Z. H.; Li, Z. Y.; Lim, S.; Lin, C. H.; Lipari, P.; Lippert, T.; Liu, D.; Liu, Hu; Lu, S. Q.; Lu, Y. S.; Luebelsmeyer, K.; Luo, F.; Luo, J. Z.; Lv, S. S.; Majka, R.; Mañá, C.; Marín, J.; Martin, T.; Martínez, G.; Masi, N.; Maurin, D.; Menchaca-Rocha, A.; Meng, Q.; Mo, D. C.; Morescalchi, L.; Mott, P.; Nelson, T.; Ni, J. Q.; Nikonov, N.; Nozzoli, F.; Nunes, P.; Oliva, A.; Orcinha, M.; Palmonari, F.; Palomares, C.; Paniccia, M.; Pauluzzi, M.; Pensotti, S.; Pereira, R.; Picot-Clemente, N.; Pilo, F.; Pizzolotto, C.; Plyaskin, V.; Pohl, M.; Poireau, V.; Putze, A.; Quadrani, L.; Qi, X. M.; Qin, X.; Qu, Z. Y.; Räihä, T.; Rancoita, P. G.; Rapin, D.; Ricol, J. S.; Rodríguez, I.; Rosier-Lees, S.; Rozhkov, A.; Rozza, D.; Sagdeev, R.; Sandweiss, J.; Saouter, P.; Schael, S.; Schmidt, S. M.; Schulz von Dratzig, A.; Schwering, G.; Seo, E. S.; Shan, B. S.; Shi, J. Y.; Siedenburg, T.; Son, D.; Song, J. W.; Sun, W. H.; Tacconi, M.; Tang, X. W.; Tang, Z. C.; Tao, L.; Tescaro, D.; Ting, Samuel C. C.; Ting, S. M.; Tomassetti, N.; Torsti, J.; Türkoǧlu, C.; Urban, T.; Vagelli, V.; Valente, E.; Vannini, C.; Valtonen, E.; Vázquez Acosta, M.; Vecchi, M.; Velasco, M.; Vialle, J. P.; Vitale, V.; Vitillo, S.; Wang, L. Q.; Wang, N. H.; Wang, Q. L.; Wang, X.; Wang, X. Q.; Wang, Z. X.; Wei, C. C.; Weng, Z. L.; Whitman, K.; Wienkenhöver, J.; Willenbrock, M.; Wu, H.; Wu, X.; Xia, X.; Xiong, R. Q.; Xu, W.; Yan, Q.; Yang, J.; Yang, M.; Yang, Y.; Yi, H.; Yu, Y. J.; Yu, Z. Q.; Zeissler, S.; Zhang, C.; Zhang, J.; Zhang, J. H.; Zhang, S. D.; Zhang, S. W.; Zhang, Z.; Zheng, Z. M.; Zhu, Z. Q.; Zhuang, H. L.; Zhukov, V.; Zichichi, A.; Zimmermann, N.; Zuccon, P.; AMS Collaboration</p> <p>2016-08-01</p> <p>A precision measurement by AMS of the antiproton <span class="hlt">flux</span> and the antiproton-to-proton <span class="hlt">flux</span> ratio in primary cosmic rays in the absolute rigidity range from 1 to 450 GV is presented based on 3.49 ×1 05 antiproton events and 2.42 ×1 09 proton events. The <span class="hlt">fluxes</span> and <span class="hlt">flux</span> ratios of charged elementary particles in cosmic rays are also presented. In the absolute rigidity range ˜60 to ˜500 GV , the antiproton p ¯, proton p , and positron e+ <span class="hlt">fluxes</span> are found to have nearly identical rigidity dependence and the <span class="hlt">electron</span> e- <span class="hlt">flux</span> exhibits a different rigidity dependence. Below 60 GV, the (p ¯/p ), (p ¯/e+), and (p /e+) <span class="hlt">flux</span> ratios each reaches a maximum. From ˜60 to ˜500 GV , the (p ¯/p ), (p ¯/e+), and (p /e+) <span class="hlt">flux</span> ratios show no rigidity dependence. These are new observations of the properties of elementary particles in the cosmos.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22687870-aryl-hydrocarbon-receptor-dependent-up-regulation-heterodimeric-amino-acid-transporter-lat1-slc7a5-cd98hc-slc3a2-diesel-exhaust-particle-extract-human-bronchial-epithelial-cells','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22687870-aryl-hydrocarbon-receptor-dependent-up-regulation-heterodimeric-amino-acid-transporter-lat1-slc7a5-cd98hc-slc3a2-diesel-exhaust-particle-extract-human-bronchial-epithelial-cells"><span>Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter <span class="hlt">LAT</span>1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Le Vee, Marc; Jouan, Elodie; Lecureur, Valérie</p> <p></p> <p>The heterodimeric L-type amino acid transporter (<span class="hlt">LAT</span>) 1/CD98hc is overexpressed in lung cancers with a poor prognosis factor. Factors that contribute to <span class="hlt">LAT</span>1/CD98hc overexpression in lung cells remain however to be determined, but the implication of atmospheric pollution can be suspected. The present study was therefore designed to analyze the effects of diesel exhaust particle (DEP) extract (DEPe) on <span class="hlt">LAT</span>1/CD98hc expression in bronchial epithelial BEAS-2B cells. Exposure to DEPe up-regulated <span class="hlt">LAT</span>1 and CD98hc mRNA levels in a concentration-dependent manner, with DEPe EC{sub 50} values (around 0.2 μg/mL) relevant to environmental situations. DEPe concomitantly induced <span class="hlt">LAT</span>1/CD98hc protein expression and <span class="hlt">LAT</span>1-mediated leucinemore » accumulation in BEAS-2B cells. Inhibition of the aryl hydrocarbon receptor (AhR) pathway through the use of a chemical AhR antagonist or the siRNA-mediated silencing of AhR expression was next found to prevent DEPe-mediated induction of <span class="hlt">LAT</span>1/CD98hc, indicating that this regulation depends on AhR, known to be activated by major chemical DEP components like polycyclic aromatic hydrocarbons. DEPe exposure was finally shown to induce mRNA expression and activity of matrix metalloproteinase (MMP)-2 in BEAS-2B cells, in a CD98hc/focal adhesion kinase (FAK)/extracellular regulated kinase (ERK) manner, thus suggesting that DEPe-mediated induction of CD98hc triggers activation of the integrin/FAK/ERK signaling pathway known to be involved in MMP-2 regulation. Taken together, these data demonstrate that exposure to DEPe induces functional overexpression of the amino acid transporter <span class="hlt">LAT</span>1/CD98hc in lung cells. Such a regulation may participate to pulmonary carcinogenic effects of DEPs, owing to the well-documented contribution of <span class="hlt">LAT</span>1 and CD98hc to cancer development. - Highlights: • The amino acid transporter <span class="hlt">LAT</span>1/CD98hc is up-regulated in DEPe-treated lung cells. • The aryl hydrocarbon receptor is involved in DEPe-triggered induction of <span class="hlt">LAT</span>1/CD</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19850026767','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19850026767"><span>Additional <span class="hlt">flux</span> of particles and albedo-<span class="hlt">electrons</span> in upper atmosphere</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Aitbaev, F. B.; Dyuisembaev, B. M.; Kolomeets, E. V.</p> <p>1985-01-01</p> <p>The results are presented of the Monte Carlo simulation of albedo <span class="hlt">flux</span> from the dense layers of the Earth's atmosphere and the dependence of angular distribution on the rigidity of geomagnetic cut off and additional <span class="hlt">flux</span> of particles at the depth in the atmosphere 15-20 g/sq sm. Influence of geomagnetic field on the propagation of charged particles was not taken into account.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014JPhG...41e5006L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014JPhG...41e5006L"><span>Testing no-scale supergravity with the Fermi Space Telescope <span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Li, Tianjun; Maxin, James A.; Nanopoulos, Dimitri V.; Walker, Joel W.</p> <p>2014-05-01</p> <p>We describe a methodology for testing no-scale supergravity by the <span class="hlt">LAT</span> instrument onboard the Fermi Space Telescope via observation of gamma ray emissions from lightest supersymmetric (SUSY) neutralino annihilations. For our test vehicle we engage the framework of the SUSY grand unified model no-scale flipped SU(5) with extra vector-like flippon multiplets derived from F-theory, known as { F}-SU(5). We show that through compression of the light stau and light bino neutralino mass difference, where internal bremsstrahlung photons give a dominant contribution, the photon yield from annihilation of SUSY dark matter can be elevated to a number of events potentially observable by the Fermi-<span class="hlt">LAT</span> in the coming years. Likewise, the increased yield in no-scale { F}-SU(5) may also have rendered the existing observation of a 133 GeV monochromatic gamma ray line visible, if additional data should exclude systematic or statistical explanations. The question of intensity aside, no-scale { F}-SU(5) can indeed provide a natural weakly interacting massive particle candidate with a mass in the correct range to yield γγ and γZ emission lines at mχ ˜ 133 GeV and mχ ˜ 145 GeV, respectively. Additionally, we elucidate the emerging empirical connection between recent Planck satellite data and no-scale supergravity cosmological models which mimic the Starobinsky model of inflation. Together, these experiments furnish rich alternate avenues for testing no-scale { F}-SU(5), and similarly structured models, the results of which may lend independent credence to observations made at the Large Hadron Collider.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012yCat..21990031N','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012yCat..21990031N"><span>VizieR Online Data Catalog: Fermi <span class="hlt">LAT</span> second source catalog (2FGL) (Nolan+, 2012)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Nolan, P. L.; Abdo, A. A.; Ackermann, M.; Ajello, M.; Allafort, A.; Antolini, E.; Atwood, W. B.; Axelsson, M.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Belfiore, A.; Bellazzini, R.; Berenji, B.; Bignami, G. F.; Blandford, R. D.; Bloom, E. D.; Bonamente, E.; Bonnell, J.; Borgland, A. W.; Bottacini, E.; Bouvier, A.; Brandt, T. J.; Bregeon, J.; Brigida, M.; Bruel, P.; Buehler, R.; Burnett, T. H.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Campana, R.; Canadas, B.; Cannon, A.; Caraveo, P. A.; Casandjian, J. M.; Cavazzuti, E.; Ceccanti, M.; Cecchi, C.; Celik, O.; Charles, E.; Chekhtman, A.; Cheung, C. C.; Chiang, J.; Chipaux, R.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Cominsky, L. R.; Conrad, J.; Corbet, R.; Cutini, S.; D'Ammando, F.; Davis, D. S.; de Angelis, A.; Decesar, M. E.; Deklotz, M.; de Luca A.; den Hartog, P. R.; de Palma, F.; Dermer, C. D.; Digel, S. W.; Do Couto, E. Silva E.; Drell, P. S.; Drlica-Wagner, A.; Dubois, R.; Dumora, D.; Enoto, T.; Escande, L.; Fabiani, D.; Falletti, L.; Favuzzi, C.; Fegan, S. J.; Ferrara, E. C.; Focke, W. B.; Fortin, P.; Frailis, M.; Fukazawa, Y.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Gehrels, N.; Germani, S.; Giebels, B.; Giglietto, N.; Giommi, P.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Grenier, I. A.; Grondin, M.-H.; Grove, J. E.; Guillemot, L.; Guiriec, S.; Gustafsson, M.; Hadasch, D.; Hanabata, Y.; Harding, A. K.; Hayashida, M.; Hays, E.; Hill, A. B.; Horan, D.; Hou, X.; Hughes, R. E.; Iafrate, G.; Itoh, R.; Johannesson, G.; Johnson, R. P.; Johnson, T. E.; Johnson, A. S.; Johnson, T. J.; Kamae, T.; Katagiri, H.; Kataoka, J.; Katsuta, J.; Kawai, N.; Kerr, M.; Knodlseder, J.; Kocevski, D.; Kuss, M.; Lande, J.; Landriu, D.; Latronico, L.; Lemoine-Goumard, M.; Lionetto, A. M.; Llena Garde, M.; Longo, F.; Loparco, F.; Lott, B.; Lovellette, M. N.; Lubrano, P.; Madejski, G. M.; Marelli, M.; Massaro, E.; Mazziotta, M. N.; McConville, W.; McEnery, J. E.; Mehault, J.; Michelson, P. F.; Minuti, M.; Mitthumsiri, W.; Mizuno, T.; Moiseev, A. A.; Mongelli, M.; Monte, C.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nakamori, T.; Naumann-God, O. M.; Norris, J. P.; Nuss, E.; Nymark, T.; Ohno, M.; Ohsugi, T.; Okumura, A.; Omodei, N.; Orlando, E.; Ormes, J. F.; Ozaki, M.; Paneque, D.; Panetta, J. H.; Parent, D.; Perkins, J. S.; Pesce-Rollins, M.; Pierbattista, M.; Pinchera, M.; Piron, F.; Pivato, G.; Porter, T. A.; Racusin, J. L.; Raino, S.; Rando, R.; Razzano, M.; Razzaque, S.; Reimer, A.; Reimer, O.; Reposeur, T.; Ritz, S.; Rochester, L. S.; Romani, R. W.; Roth, M.; Rousseau, R.; Ryde, F.; Sadrozinski, H. F.-W.; Salvetti, D.; Sanchez, D. A.; Saz Parkinson, P. M.; Sbarra, C.; Scargle, J. D.; Schalk, T. L.; Sgro, C.; Shaw, M. S.; Shrader, C.; Siskind, E. J.; Smith, D. A.; Spandre, G.; Spinelli, P.; Stephens, T. E.; Strickman, M. S.; Suson, D. J.; Tajima, H.; Takahashi, H.; Takahashi, T.; Tanaka, T.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Tibaldo, L.; Tibolla, O.; Tinebra, F.; Tinivella, M.; Torres, D. F.; Tosti, G.; Troja, E.; Uchiyama, Y.; Vandenbroucke, J.; van Etten, A.; van Klaveren, B.; Vasileiou, V.; Vianello, G.; Vitale, V.; Waite, A. P.; Wallace, E.; Wang, P.; Werner, M.; Winer, B. L.; Wood, D. L.; Wood, K. S.; Wood, M.; Yang, Z.; Zimmer, S.</p> <p>2012-06-01</p> <p>This paper presents a catalog of high-energy γ-ray sources detected, in the 100MeV-100GeV energy range, in the first two years of the Fermi Gamma-ray Space Telescope mission by the Large Area Telescope (<span class="hlt">LAT</span>), during the period 2008 August 4 (15:43 UTC)-2010 August 1 (01:17 UTC). (4 data files).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018ATel11590....1L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018ATel11590....1L"><span>Bright gamma-ray emission from TCP J04432130+4721280 (V392 Per) detected by Fermi-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Li, Kwan-Lok; Chomiuk, Laura; Strader, Jay</p> <p>2018-05-01</p> <p>We report the Fermi-<span class="hlt">LAT</span> detection of the optical transient TCP J04432130+4721280 (V392 Per), which was discovered by Yuji Nakamura on 2018-04-29.4740 (CBET #4515) and later identified as a Galactic nova by Wagner et al. (ATel #11588).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3068929','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3068929"><span>Reactive Oxygen Species Production by Forward and Reverse <span class="hlt">Electron</span> <span class="hlt">Fluxes</span> in the Mitochondrial Respiratory Chain</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Selivanov, Vitaly A.; Votyakova, Tatyana V.; Pivtoraiko, Violetta N.; Zeak, Jennifer; Sukhomlin, Tatiana; Trucco, Massimo; Roca, Josep; Cascante, Marta</p> <p>2011-01-01</p> <p>Reactive oxygen species (ROS) produced in the mitochondrial respiratory chain (RC) are primary signals that modulate cellular adaptation to environment, and are also destructive factors that damage cells under the conditions of hypoxia/reoxygenation relevant for various systemic diseases or transplantation. The important role of ROS in cell survival requires detailed investigation of mechanism and determinants of ROS production. To perform such an investigation we extended our rule-based model of complex III in order to account for <span class="hlt">electron</span> transport in the whole RC coupled to proton translocation, transmembrane electrochemical potential generation, TCA cycle reactions, and substrate transport to mitochondria. It fits respiratory <span class="hlt">electron</span> <span class="hlt">fluxes</span> measured in rat brain mitochondria fueled by succinate or pyruvate and malate, and the dynamics of NAD+ reduction by reverse <span class="hlt">electron</span> transport from succinate through complex I. The fitting of measured characteristics gave an insight into the mechanism of underlying processes governing the formation of free radicals that can transfer an unpaired <span class="hlt">electron</span> to oxygen-producing superoxide and thus can initiate the generation of ROS. Our analysis revealed an association of ROS production with levels of specific radicals of individual <span class="hlt">electron</span> transporters and their combinations in species of complexes I and III. It was found that the phenomenon of bistability, revealed previously as a property of complex III, remains valid for the whole RC. The conditions for switching to a state with a high content of free radicals in complex III were predicted based on theoretical analysis and were confirmed experimentally. These findings provide a new insight into the mechanisms of ROS production in RC. PMID:21483483</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1357544-fermi-lat-observations-supernova-remnant-w28-g6','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1357544-fermi-lat-observations-supernova-remnant-w28-g6"><span>Fermi <span class="hlt">LAT</span> Observations of the Supernova Remnant W28 (G6.4-0.1)</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Abdo, A. A.; Ackermann, M.; Ajello, M.; ...</p> <p>2010-06-30</p> <p>Here, we present detailed analysis of two gamma-ray sources, 1FGL J1801.3–2322c and 1FGL J1800.5–2359c, that have been found toward the supernova remnant (SNR) W28 with the Large Area Telescope (<span class="hlt">LAT</span>) on board the Fermi Gamma-ray Space Telescope. 1FGL J1801.3–2322c is found to be an extended source within the boundary of SNR W28, and to extensively overlap with the TeV gamma-ray source HESS J1801–233, which is associated with a dense molecular cloud interacting with the SNR. The gamma-ray spectrum measured with the <span class="hlt">LAT</span> from 0.2 to 100 GeV can be described by a broken power-law function with a break at ~1more » GeV and photon indices of 2.09 ± 0.08 (stat) ± 0.28 (sys) below the break and 2.74 ± 0.06 (stat) ± 0.09 (sys) above the break. Given the clear association between HESS J1801–233 and the shocked molecular cloud and a smoothly connected spectrum in the GeV-TeV band, we consider the origin of the gamma-ray emission in both GeV and TeV ranges to be the interaction between particles accelerated in the SNR and the molecular cloud. The decay of neutral pions produced in interactions between accelerated hadrons and dense molecular gas provides a reasonable explanation for the broadband gamma-ray spectrum. 1FGL J1800.5–2359c, located outside the southern boundary of SNR W28, cannot be resolved. An upper limit on the size of the gamma-ray emission was estimated to be ~16' using events above ~2 GeV under the assumption of a circular shape with uniform surface brightness. It appears to coincide with the TeV source HESS J1800–240B, which is considered to be associated with a dense molecular cloud that contains the ultra compact H II region W28A2 (G5.89–0.39). In conclusion, we found no significant gamma-ray emission in the <span class="hlt">LAT</span> energy band at the positions of TeV sources HESS J1800–230A and HESS J1800–230C. The <span class="hlt">LAT</span> data for HESS J1800–230A combined with the TeV data points indicate a spectral break between 10 GeV and 100 GeV.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1221230-limits-dark-matter-annihilation-signals-from-fermi-lat-year-measurement-isotropic-gamma-ray-background','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1221230-limits-dark-matter-annihilation-signals-from-fermi-lat-year-measurement-isotropic-gamma-ray-background"><span>Limits on dark matter annihilation signals from the Fermi <span class="hlt">LAT</span> 4-year measurement of the isotropic gamma-ray background</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Ackermann, M.</p> <p>2015-09-02</p> <p>We search for evidence of dark matter (DM) annihilation in the isotropic gamma-ray background (IGRB) measured with 50 months of Fermi Large Area Telescope (<span class="hlt">LAT</span>) observations. An improved theoretical description of the cosmological DM annihilation signal, based on two complementary techniques and assuming generic weakly interacting massive particle (WIMP) properties, renders more precise predictions compared to previous work. More specifically, we estimate the cosmologically-induced gamma-ray intensity to have an uncertainty of a factor ~ 20 in canonical setups. We consistently include both the Galactic and extragalactic signals under the same theoretical framework, and study the impact of the former onmore » the IGRB spectrum derivation. We find no evidence for a DM signal and we set limits on the DM-induced isotropic gamma-ray signal. Our limits are competitive for DM particle masses up to tens of TeV and, indeed, are the strongest limits derived from Fermi <span class="hlt">LAT</span> data at TeV energies. This is possible thanks to the new Fermi <span class="hlt">LAT</span> IGRB measurement, which now extends up to an energy of 820 GeV. As a result, we quantify uncertainties in detail and show the potential this type of search offers for testing the WIMP paradigm with a complementary and truly cosmological probe of DM particle signals.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22525468-limits-dark-matter-annihilation-signals-from-fermi-lat-year-measurement-isotropic-gamma-ray-background','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22525468-limits-dark-matter-annihilation-signals-from-fermi-lat-year-measurement-isotropic-gamma-ray-background"><span>Limits on dark matter annihilation signals from the Fermi <span class="hlt">LAT</span> 4-year measurement of the isotropic gamma-ray background</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Collaboration: Fermi LAT Collaboration</p> <p>2015-09-01</p> <p>We search for evidence of dark matter (DM) annihilation in the isotropic gamma-ray background (IGRB) measured with 50 months of Fermi Large Area Telescope (<span class="hlt">LAT</span>) observations. An improved theoretical description of the cosmological DM annihilation signal, based on two complementary techniques and assuming generic weakly interacting massive particle (WIMP) properties, renders more precise predictions compared to previous work. More specifically, we estimate the cosmologically-induced gamma-ray intensity to have an uncertainty of a factor ∼ 20 in canonical setups. We consistently include both the Galactic and extragalactic signals under the same theoretical framework, and study the impact of the former on themore » IGRB spectrum derivation. We find no evidence for a DM signal and we set limits on the DM-induced isotropic gamma-ray signal. Our limits are competitive for DM particle masses up to tens of TeV and, indeed, are the strongest limits derived from Fermi <span class="hlt">LAT</span> data at TeV energies. This is possible thanks to the new Fermi <span class="hlt">LAT</span> IGRB measurement, which now extends up to an energy of 820 GeV. We quantify uncertainties in detail and show the potential this type of search offers for testing the WIMP paradigm with a complementary and truly cosmological probe of DM particle signals.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/27610839','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/27610839"><span>Antiproton <span class="hlt">Flux</span>, Antiproton-to-Proton <span class="hlt">Flux</span> Ratio, and Properties of Elementary Particle <span class="hlt">Fluxes</span> in Primary Cosmic Rays Measured with the Alpha Magnetic Spectrometer on the International Space Station.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Aguilar, M; Ali Cavasonza, L; Alpat, B; Ambrosi, G; Arruda, L; Attig, N; Aupetit, S; Azzarello, P; Bachlechner, A; Barao, F; Barrau, A; Barrin, L; Bartoloni, A; Basara, L; Başeǧmez-du Pree, S; Battarbee, M; Battiston, R; Bazo, J; Becker, U; Behlmann, M; Beischer, B; Berdugo, J; Bertucci, B; Bindi, V; Boella, G; de Boer, W; Bollweg, K; Bonnivard, V; Borgia, B; Boschini, M J; Bourquin, M; Bueno, E F; Burger, J; Cadoux, F; Cai, X D; Capell, M; Caroff, S; Casaus, J; Castellini, G; Cernuda, I; Cervelli, F; Chae, M J; Chang, Y H; Chen, A I; Chen, G M; Chen, H S; Cheng, L; Chou, H Y; Choumilov, E; Choutko, V; Chung, C H; Clark, C; Clavero, R; Coignet, G; Consolandi, C; Contin, A; Corti, C; Coste, B; Creus, W; Crispoltoni, M; Cui, Z; Dai, Y M; Delgado, C; Della Torre, S; Demirköz, M B; Derome, L; Di Falco, S; Dimiccoli, F; Díaz, C; von Doetinchem, P; Dong, F; Donnini, F; Duranti, M; D'Urso, D; Egorov, A; Eline, A; Eronen, T; Feng, J; Fiandrini, E; Finch, E; Fisher, P; Formato, V; Galaktionov, Y; Gallucci, G; García, B; García-López, R J; Gargiulo, C; Gast, H; Gebauer, I; Gervasi, M; Ghelfi, A; Giovacchini, F; Goglov, P; Gómez-Coral, D M; Gong, J; Goy, C; Grabski, V; Grandi, D; Graziani, M; Guerri, I; Guo, K H; Habiby, M; Haino, S; Han, K C; He, Z H; Heil, M; Hoffman, J; Hsieh, T H; Huang, H; Huang, Z C; Huh, C; Incagli, M; Ionica, M; Jang, W Y; Jinchi, H; Kang, S C; Kanishev, K; Kim, G N; Kim, K S; Kirn, Th; Konak, C; Kounina, O; Kounine, A; Koutsenko, V; Krafczyk, M S; La Vacca, G; Laudi, E; Laurenti, G; Lazzizzera, I; Lebedev, A; Lee, H T; Lee, S C; Leluc, C; Li, H S; Li, J Q; Li, J Q; Li, Q; Li, T X; Li, W; Li, Z H; Li, Z Y; Lim, S; Lin, C H; Lipari, P; Lippert, T; Liu, D; Liu, Hu; Lu, S Q; Lu, Y S; Luebelsmeyer, K; Luo, F; Luo, J Z; Lv, S S; Majka, R; Mañá, C; Marín, J; Martin, T; Martínez, G; Masi, N; Maurin, D; Menchaca-Rocha, A; Meng, Q; Mo, D C; Morescalchi, L; Mott, P; Nelson, T; Ni, J Q; Nikonov, N; Nozzoli, F; Nunes, P; Oliva, A; Orcinha, M; Palmonari, F; Palomares, C; Paniccia, M; Pauluzzi, M; Pensotti, S; Pereira, R; Picot-Clemente, N; Pilo, F; Pizzolotto, C; Plyaskin, V; Pohl, M; Poireau, V; Putze, A; Quadrani, L; Qi, X M; Qin, X; Qu, Z Y; Räihä, T; Rancoita, P G; Rapin, D; Ricol, J S; Rodríguez, I; Rosier-Lees, S; Rozhkov, A; Rozza, D; Sagdeev, R; Sandweiss, J; Saouter, P; Schael, S; Schmidt, S M; Schulz von Dratzig, A; Schwering, G; Seo, E S; Shan, B S; Shi, J Y; Siedenburg, T; Son, D; Song, J W; Sun, W H; Tacconi, M; Tang, X W; Tang, Z C; Tao, L; Tescaro, D; Ting, Samuel C C; Ting, S M; Tomassetti, N; Torsti, J; Türkoğlu, C; Urban, T; Vagelli, V; Valente, E; Vannini, C; Valtonen, E; Vázquez Acosta, M; Vecchi, M; Velasco, M; Vialle, J P; Vitale, V; Vitillo, S; Wang, L Q; Wang, N H; Wang, Q L; Wang, X; Wang, X Q; Wang, Z X; Wei, C C; Weng, Z L; Whitman, K; Wienkenhöver, J; Willenbrock, M; Wu, H; Wu, X; Xia, X; Xiong, R Q; Xu, W; Yan, Q; Yang, J; Yang, M; Yang, Y; Yi, H; Yu, Y J; Yu, Z Q; Zeissler, S; Zhang, C; Zhang, J; Zhang, J H; Zhang, S D; Zhang, S W; Zhang, Z; Zheng, Z M; Zhu, Z Q; Zhuang, H L; Zhukov, V; Zichichi, A; Zimmermann, N; Zuccon, P</p> <p>2016-08-26</p> <p>A precision measurement by AMS of the antiproton <span class="hlt">flux</span> and the antiproton-to-proton <span class="hlt">flux</span> ratio in primary cosmic rays in the absolute rigidity range from 1 to 450 GV is presented based on 3.49×10^{5} antiproton events and 2.42×10^{9} proton events. The <span class="hlt">fluxes</span> and <span class="hlt">flux</span> ratios of charged elementary particles in cosmic rays are also presented. In the absolute rigidity range ∼60 to ∼500  GV, the antiproton p[over ¯], proton p, and positron e^{+} <span class="hlt">fluxes</span> are found to have nearly identical rigidity dependence and the <span class="hlt">electron</span> e^{-} <span class="hlt">flux</span> exhibits a different rigidity dependence. Below 60 GV, the (p[over ¯]/p), (p[over ¯]/e^{+}), and (p/e^{+}) <span class="hlt">flux</span> ratios each reaches a maximum. From ∼60 to ∼500  GV, the (p[over ¯]/p), (p[over ¯]/e^{+}), and (p/e^{+}) <span class="hlt">flux</span> ratios show no rigidity dependence. These are new observations of the properties of elementary particles in the cosmos.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2010AnGeo..28..455S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2010AnGeo..28..455S"><span>Bi-layer structure of counterstreaming energetic <span class="hlt">electron</span> <span class="hlt">fluxes</span>: a diagnostic tool of the acceleration mechanism in the Earth's magnetotail</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Sarafopoulos, D. V.</p> <p>2010-02-01</p> <p>For the first time we identify a bi-layer structure of energetic <span class="hlt">electron</span> <span class="hlt">fluxes</span> in the Earth's magnetotail and establish (using datasets mainly obtained by the Geotail Energetic Particles and Ion Composition (EPIC/ICS) instrument) that it actually provides strong evidence for a purely spatial structure. Each bi-layer event is composed of two distinct layers with counterstreaming energetic <span class="hlt">electron</span> <span class="hlt">fluxes</span>, parallel and antiparallel to the local ambient magnetic field lines; in particular, the tailward directed <span class="hlt">fluxes</span> always occur in a region adjacent to the lobes. Adopting the X-line as a standard reconnection model, we determine the occurrence of bi-layer events relatively to the neutral point, in the substorm frame; four (out of the shown seven) events are observed earthward and three tailward, a result implying that four events probably occurred with the substorm's local recovery phase. We discuss the bi-layer events in terms of the X-line model; they add more constraints for any candidate <span class="hlt">electron</span> acceleration mechanism. It should be stressed that until this time, none proposed <span class="hlt">electron</span> acceleration mechanism has discussed or predicted these layered structures with all their properties. Then we discuss the bi-layer events in terms of the much promising "akis model", as introduced by Sarafopoulos (2008). The akis magnetic field topology is embedded in a thinned plasma sheet and is potentially causing charge separation. We assume that as the Rc curvature radius of the magnetic field line tends to become equal to the ion gyroradius rg, then the ions become non-adiabatic. At the limit Rc=rg the demagnetization process is also under way and the frozen-in magnetic field condition is violated by strong wave turbulence; hence, the ion particles in this geometry are stochastically scattered. In addition, ion diffusion probably takes place across the magnetic field, since an intense pressure gradient is directed earthward; hence, ions are ejected tailward of akis. This</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JGRA..12211961B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JGRA..12211961B"><span>Time-Integral Correlations of Multiple Variables With the Relativistic-<span class="hlt">Electron</span> <span class="hlt">Flux</span> at Geosynchronous Orbit: The Strong Roles of Substorm-Injected <span class="hlt">Electrons</span> and the Ion Plasma Sheet</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Borovsky, Joseph E.</p> <p>2017-12-01</p> <p>Time-integral correlations are examined between the geosynchronous relativistic <span class="hlt">electron</span> <span class="hlt">flux</span> index Fe1.2 and 31 variables of the solar wind and magnetosphere. An "evolutionary algorithm" is used to maximize correlations. Time integrations (into the past) of the variables are found to be superior to time-lagged variables for maximizing correlations with the radiation belt. Physical arguments are given as to why. Dominant correlations are found for the substorm-injected <span class="hlt">electron</span> <span class="hlt">flux</span> at geosynchronous orbit and for the pressure of the ion plasma sheet. Different sets of variables are constructed and correlated with Fe1.2: some sets maximize the correlations, and some sets are based on purely solar wind variables. Examining known physical mechanisms that act on the radiation belt, sets of correlations are constructed (1) using magnetospheric variables that control those physical mechanisms and (2) using the solar wind variables that control those magnetospheric variables. Fe1.2-increasing intervals are correlated separately from Fe1.2-decreasing intervals, and the introduction of autoregression into the time-integral correlations is explored. A great impediment to discerning physical cause and effect from the correlations is the fact that all solar wind variables are intercorrelated and carry much of the same information about the time sequence of the solar wind that drives the time sequence of the magnetosphere.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016ATel.9771....1L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016ATel.9771....1L"><span>Fermi-<span class="hlt">LAT</span> Observations of Continued Gamma-ray Activity from Nova ASASSN-16ma</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Li, Kwan-Lok; Chomiuk, Laura; Strader, Jay; Cheung, C. C.; Jean, P.; Shore, S. N.; Fermi Large Area Telescope Collaboration</p> <p>2016-11-01</p> <p>Following the report of a sudden gamma-ray onset detection of nova ASASSN-16ma coincident with the optical peak of 5.5 mag on November 8 (ATel #9736), ASASSN-16ma was observed to slowly decrease in gamma-rays but has remained bright enough to be detectable with Fermi-<span class="hlt">LAT</span> over the last 9 days (test statistic, TS > 10 per day, except for November 17 with TS=5).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JEMat..47.4190P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JEMat..47.4190P"><span>Parametric Study of Solder <span class="hlt">Flux</span> Hygroscopicity: Impact of Weak Organic Acids on Water Layer Formation and Corrosion of <span class="hlt">Electronics</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Piotrowska, Kamila; Ud Din, Rameez; Grumsen, Flemming Bjerg; Jellesen, Morten Stendahl; Ambat, Rajan</p> <p>2018-07-01</p> <p>The presence of solder <span class="hlt">flux</span> residues on the printed circuit board assembly surface is an important factor contributing to humidity-related reliability issues that affect device lifetime. This investigation focuses on understanding the hygroscopic nature of typical wave solder <span class="hlt">flux</span> activators—weak organic acids—under varied temperature conditions. In situ x-ray diffraction measurements assessed the effect of high temperature on the crystal structure of organic activators. The hygroscopicity studies were carried out under relative humidity (RH) levels varying from 30% to ˜ 99% and at temperatures 25°C, 40°C, and 60°C. Water absorption levels were determined using the gravimetric method, and the influence on reliability was assessed using electrochemical impedance and leak current measurements performed on the surface insulation resistance comb patterns. The corrosion studies were correlated with the hygroscopicity results and solubility data. Corrosion morphology was analysed using the optical microscopy and scanning <span class="hlt">electron</span> microscopy. The results show that the hygroscopic nature of typical solder <span class="hlt">flux</span> residue depends on its chemical structure and temperature. An increase of temperature shifts the critical RH level for water vapour absorption towards lower RH range, accelerating the formation of a conductive electrolyte and the occurrence of ion transport-induced electrochemical migration. The overall ranking of <span class="hlt">flux</span> activators with the increasing order of aggressivity is: palmitic < suberic < adipic < succinic < glutaric < dl-malic acid.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JEMat.tmp.2673P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JEMat.tmp.2673P"><span>Parametric Study of Solder <span class="hlt">Flux</span> Hygroscopicity: Impact of Weak Organic Acids on Water Layer Formation and Corrosion of <span class="hlt">Electronics</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Piotrowska, Kamila; Ud Din, Rameez; Grumsen, Flemming Bjerg; Jellesen, Morten Stendahl; Ambat, Rajan</p> <p>2018-04-01</p> <p>The presence of solder <span class="hlt">flux</span> residues on the printed circuit board assembly surface is an important factor contributing to humidity-related reliability issues that affect device lifetime. This investigation focuses on understanding the hygroscopic nature of typical wave solder <span class="hlt">flux</span> activators—weak organic acids—under varied temperature conditions. In situ x-ray diffraction measurements assessed the effect of high temperature on the crystal structure of organic activators. The hygroscopicity studies were carried out under relative humidity (RH) levels varying from 30% to ˜ 99% and at temperatures 25°C, 40°C, and 60°C. Water absorption levels were determined using the gravimetric method, and the influence on reliability was assessed using electrochemical impedance and leak current measurements performed on the surface insulation resistance comb patterns. The corrosion studies were correlated with the hygroscopicity results and solubility data. Corrosion morphology was analysed using the optical microscopy and scanning <span class="hlt">electron</span> microscopy. The results show that the hygroscopic nature of typical solder <span class="hlt">flux</span> residue depends on its chemical structure and temperature. An increase of temperature shifts the critical RH level for water vapour absorption towards lower RH range, accelerating the formation of a conductive electrolyte and the occurrence of ion transport-induced electrochemical migration. The overall ranking of <span class="hlt">flux</span> activators with the increasing order of aggressivity is: palmitic < suberic < adipic < succinic < glutaric < uc(dl)-malic acid.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016ApJ...827...41Y','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016ApJ...827...41Y"><span>Studying the SGR 1806-20/Cl* 1806-20 Region Using the Fermi Large Area Telescope</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Yeung, Paul K. H.; Kong, Albert K. H.; Tam, P. H. Thomas; Lin, Lupin C. C.; Hui, C. Y.; Hu, Chin-Ping; Cheng, K. S.</p> <p>2016-08-01</p> <p>The region around SGR 1806-20 and its host stellar cluster Cl* 1806-20 is a potentially important site of particle acceleration. The soft γ-ray repeater and Cl* 1806-20, which also contains several very massive stars including a luminous blue variable hypergiant LBV 1806-20, are capable of depositing a large amount of energy to the surroundings. Using the data taken with the Fermi Large Area Telescope (<span class="hlt">LAT</span>), we identified an extended <span class="hlt">LAT</span> source to the southwest of Cl* 1806-20. The centroid of the 1-50 GeV emission is consistent with that of HESS J1808-204 (until now unidentified). The <span class="hlt">LAT</span> spectrum is best-fit by a broken power law with the break energy {E}{{b}}=297+/- 15 {MeV}. The index above E b is 2.60 ± 0.04 and is consistent with the <span class="hlt">flux</span> and spectral index above 100 GeV for HESS J1808-204, suggesting an association between the two sources. Meanwhile, the interacting supernova remnant SNR G9.7-0.0 is also a potential contributor to the <span class="hlt">LAT</span> <span class="hlt">flux</span>. A tentative <span class="hlt">flux</span> enhancement at the MeV band during a 45 day interval (2011 January 21-March 7) is also reported. We discuss possible origins of the extended <span class="hlt">LAT</span> source in the context of both leptonic and hadronic scenarios.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_21 --> <div id="page_22" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="421"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22664011-contribution-fermi-blazars-diffuse-tevpev-neutrino-flux','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22664011-contribution-fermi-blazars-diffuse-tevpev-neutrino-flux"><span>THE CONTRIBUTION OF FERMI -2LAC BLAZARS TO DIFFUSE TEV–PEV NEUTRINO <span class="hlt">FLUX</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Aartsen, M. G.; Abraham, K.; Ackermann, M.</p> <p>2017-01-20</p> <p>The recent discovery of a diffuse cosmic neutrino <span class="hlt">flux</span> extending up to PeV energies raises the question of which astrophysical sources generate this signal. Blazars are one class of extragalactic sources which may produce such high-energy neutrinos. We present a likelihood analysis searching for cumulative neutrino emission from blazars in the 2nd Fermi -<span class="hlt">LAT</span> AGN catalog (2LAC) using IceCube neutrino data set 2009-12, which was optimized for the detection of individual sources. In contrast to those in previous searches with IceCube, the populations investigated contain up to hundreds of sources, the largest one being the entire blazar sample in themore » 2LAC catalog. No significant excess is observed, and upper limits for the cumulative <span class="hlt">flux</span> from these populations are obtained. These constrain the maximum contribution of 2LAC blazars to the observed astrophysical neutrino <span class="hlt">flux</span> to 27% or less between around 10 TeV and 2 PeV, assuming the equipartition of flavors on Earth and a single power-law spectrum with a spectral index of −2.5. We can still exclude the fact that 2LAC blazars (and their subpopulations) emit more than 50% of the observed neutrinos up to a spectral index as hard as −2.2 in the same energy range. Our result takes into account the fact that the neutrino source count distribution is unknown, and it does not assume strict proportionality of the neutrino <span class="hlt">flux</span> to the measured 2LAC γ -ray signal for each source. Additionally, we constrain recent models for neutrino emission by blazars.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22220612-benchmarking-gyrokinetic-simulations-toroidal-flux-tube','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22220612-benchmarking-gyrokinetic-simulations-toroidal-flux-tube"><span>Benchmarking gyrokinetic simulations in a toroidal <span class="hlt">flux</span>-tube</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Chen, Y.; Parker, S. E.; Wan, W.</p> <p>2013-09-15</p> <p>A <span class="hlt">flux</span>-tube model is implemented in the global turbulence code GEM [Y. Chen and S. E. Parker, J. Comput. Phys. 220, 839 (2007)] in order to facilitate benchmarking with Eulerian codes. The global GEM assumes the magnetic equilibrium to be completely given. The initial <span class="hlt">flux</span>-tube implementation simply selects a radial location as the center of the <span class="hlt">flux</span>-tube and a radial size of the <span class="hlt">flux</span>-tube, sets all equilibrium quantities (B, ∇B, etc.) to be equal to the values at the center of the <span class="hlt">flux</span>-tube, and retains only a linear radial profile of the safety factor needed for boundary conditions. This implementationmore » shows disagreement with Eulerian codes in linear simulations. An alternative <span class="hlt">flux</span>-tube model based on a complete local equilibrium solution of the Grad-Shafranov equation [J. Candy, Plasma Phys. Controlled Fusion 51, 105009 (2009)] is then implemented. This results in better agreement between Eulerian codes and the particle-in-cell (PIC) method. The PIC algorithm based on the v{sub ||}-formalism [J. Reynders, Ph.D. dissertation, Princeton University, 1992] and the gyrokinetic ion/fluid <span class="hlt">electron</span> hybrid model with kinetic <span class="hlt">electron</span> closure [Y. Chan and S. E. Parker, Phys. Plasmas 18, 055703 (2011)] are also implemented in the <span class="hlt">flux</span>-tube geometry and compared with the direct method for both the ion temperature gradient driven modes and the kinetic ballooning modes.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20150009314','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20150009314"><span>Milagro Observations of Potential TeV Emitters</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Abdo, A. A.; Abeysekara, A. U.; Allen, B. T.; Aune, T.; Barber, A. S.; Berley, D.; Braun, J.; Chen, C.; Christopher, G. E.; DeYoung, T.; <a style="text-decoration: none; " href="javascript:void(0); " onClick="displayelement('author_20150009314'); toggleEditAbsImage('author_20150009314_show'); toggleEditAbsImage('author_20150009314_hide'); "> <img style="display:inline; width:12px; height:12px; " src="images/arrow-up.gif" width="12" height="12" border="0" alt="hide" id="author_20150009314_show"> <img style="width:12px; height:12px; display:none; " src="images/arrow-down.gif" width="12" height="12" border="0" alt="hide" id="author_20150009314_hide"></p> <p>2014-01-01</p> <p>This paper reports the results from three targeted searches of Milagro TeV sky maps: two extragalactic point source lists and one pulsar source list. The first extragalactic candidate list consists of 709 candidates selected from the Fermi-<span class="hlt">LAT</span> 2FGL catalog. The second extragalactic candidate list contains 31 candidates selected from the TeVCat source catalog that have been detected by imaging atmospheric Cherenkov telescopes (IACTs). In both extragalactic candidate lists Mkn 421 was the only source detected by Milagro. This paper presents the Milagro TeV <span class="hlt">flux</span> for Mkn 421 and <span class="hlt">flux</span> limits for the brighter Fermi- <span class="hlt">LAT</span> extragalactic sources and for all TeVCat candidates. The pulsar list extends a previously published Milagro targeted search for Galactic sources. With the 32 new gamma-ray pulsars identified in 2FGL, the number of pulsars that are studied by both Fermi-<span class="hlt">LAT</span> and Milagro is increased to 52. In this sample, we find that the probability of Milagro detecting a TeV emission coincident with a pulsar increases with the GeV <span class="hlt">flux</span> observed by the Fermi-<span class="hlt">LAT</span> in the energy range from 0.1 GeV to 100 GeV.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19900000331&hterms=current+feedback&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dcurrent%2Bfeedback','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19900000331&hterms=current+feedback&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dcurrent%2Bfeedback"><span><span class="hlt">Flux</span>-Feedback Magnetic-Suspension Actuator</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Groom, Nelson J.</p> <p>1990-01-01</p> <p><span class="hlt">Flux</span>-feedback magnetic-suspension actuator provides magnetic suspension and control forces having linear transfer characteristics between force command and force output over large range of gaps. Hall-effect devices used as sensors for <span class="hlt">electronic</span> feedback circuit controlling currents flowing in electromagnetic windings to maintain <span class="hlt">flux</span> linking suspended element at substantially constant value independent of changes in length of gap. Technique provides effective method for maintenance of constant <span class="hlt">flux</span> density in gap and simpler than previous methods. Applications include magnetic actuators for control of shapes and figures of antennas and of precise segmented reflectors, magnetic suspensions in devices for storage of angular momentum and/or kinetic energy, and systems for control, pointing, and isolation of instruments.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1356551-einstein-home-discovery-four-young-gamma-ray-pulsars-fermi-lat-data','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1356551-einstein-home-discovery-four-young-gamma-ray-pulsars-fermi-lat-data"><span>Einstein@home discovery of four young gamma-ray pulsars in Fermi <span class="hlt">LAT</span> data</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Pletsch, Holger J.; Guillemot, L.; Allen, B.; ...</p> <p>2013-11-26</p> <p>Here, we report the discovery of four gamma-ray pulsars, detected in computing-intensive blind searches of data from the Fermi Large Area Telescope (<span class="hlt">LAT</span>). The pulsars were found using a novel search approach, combining volunteer distributed computing via Einstein@Home and methods originally developed in gravitational-wave astronomy. The pulsars PSRs J0554+3107, J1422–6138, J1522–5735, and J1932+1916 are young and energetic, with characteristic ages between 35 and 56 kyr and spin-down powers in the range 6 × 10 34—10 36 erg s –1. They are located in the Galactic plane and have rotation rates of less than 10 Hz, among which the 2.1 Hzmore » spin frequency of PSR J0554+3107 is the slowest of any known gamma-ray pulsar. For two of the new pulsars, we find supernova remnants coincident on the sky and discuss the plausibility of such associations. Deep radio follow-up observations found no pulsations, suggesting that all four pulsars are radio-quiet as viewed from Earth. These discoveries, the first gamma-ray pulsars found by volunteer computing, motivate continued blind pulsar searches of the many other unidentified <span class="hlt">LAT</span> gamma-ray sources.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013ApJ...763L..13R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013ApJ...763L..13R"><span>Radio Detection of the Fermi-<span class="hlt">LAT</span> Blind Search Millisecond Pulsar J1311-3430</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ray, P. S.; Ransom, S. M.; Cheung, C. C.; Giroletti, M.; Cognard, I.; Camilo, F.; Bhattacharyya, B.; Roy, J.; Romani, R. W.; Ferrara, E. C.; Guillemot, L.; Johnston, S.; Keith, M.; Kerr, M.; Kramer, M.; Pletsch, H. J.; Saz Parkinson, P. M.; Wood, K. S.</p> <p>2013-01-01</p> <p>We report the detection of radio emission from PSR J1311-3430, the first millisecond pulsar (MSP) discovered in a blind search of Fermi Large Area Telescope (<span class="hlt">LAT</span>) gamma-ray data. We detected radio pulsations at 2 GHz, visible for <10% of ~4.5 hr of observations using the Green Bank Telescope (GBT). Observations at 5 GHz with the GBT and at several lower frequencies with Parkes, Nançay, and the Giant Metrewave Radio Telescope resulted in non-detections. We also report the faint detection of a steep spectrum continuum radio source (0.1 mJy at 5 GHz) in interferometric imaging observations with the Jansky Very Large Array. These detections demonstrate that PSR J1311-3430 is not radio quiet and provide additional evidence that radio-quiet MSPs are rare. The radio dispersion measure of 37.8 pc cm-3 provides a distance estimate of 1.4 kpc for the system, yielding a gamma-ray efficiency of 30%, typical of <span class="hlt">LAT</span>-detected MSPs. We see apparent excess delay in the radio pulses as the pulsar appears from eclipse and we speculate on possible mechanisms for the non-detections of the pulse at other orbital phases and observing frequencies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20130013677','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20130013677"><span>Radio Detection of the Fermi-<span class="hlt">LAT</span> Blind Search Millisecond Pulsar J1311-3430</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ray, P. S.; Ransom, S. M.; Cheung, C. C.; Giroletti, M.; Cognard, I.; Camilo, F.; Bhattacharyya, B.; Roy, J.; Romani, R. W.; Ferrara, E. C.; <a style="text-decoration: none; " href="javascript:void(0); " onClick="displayelement('author_20130013677'); toggleEditAbsImage('author_20130013677_show'); toggleEditAbsImage('author_20130013677_hide'); "> <img style="display:inline; width:12px; height:12px; " src="images/arrow-up.gif" width="12" height="12" border="0" alt="hide" id="author_20130013677_show"> <img style="width:12px; height:12px; display:none; " src="images/arrow-down.gif" width="12" height="12" border="0" alt="hide" id="author_20130013677_hide"></p> <p>2013-01-01</p> <p>We report the detection of radio emission from PSR J1311.3430, the first millisecond pulsar (MSP) discovered in a blind search of Fermi Large Area Telescope (<span class="hlt">LAT</span>) gamma-ray data. We detected radio pulsations at 2 GHz, visible for less than 10% of approximately 4.5 hr of observations using the Green Bank Telescope (GBT). Observations at 5 GHz with the GBT and at several lower frequencies with Parkes, Nan cay, and the Giant Metrewave Radio Telescope resulted in non-detections. We also report the faint detection of a steep spectrum continuum radio source (0.1 mJy at 5 GHz) in interferometric imaging observations with the Jansky Very Large Array. These detections demonstrate that PSR J1311.3430 is not radio quiet and provide additional evidence that radio-quiet MSPs are rare. The radio dispersion measure of 37.8 pc cm(exp -3) provides a distance estimate of 1.4 kpc for the system, yielding a gamma-ray efficiency of 30%, typical of <span class="hlt">LAT</span>-detected MSPs. We see apparent excess delay in the radio pulses as the pulsar appears from eclipse and we speculate on possible mechanisms for the non-detections of the pulse at other orbital phases and observing frequencies.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22364093-einstein-home-discovery-four-young-gamma-ray-pulsars-fermi-lat-data','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22364093-einstein-home-discovery-four-young-gamma-ray-pulsars-fermi-lat-data"><span>EINSTEIN@HOME DISCOVERY OF FOUR YOUNG GAMMA-RAY PULSARS IN FERMI <span class="hlt">LAT</span> DATA</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Pletsch, H. J.; Allen, B.; Aulbert, C.</p> <p>2013-12-10</p> <p>We report the discovery of four gamma-ray pulsars, detected in computing-intensive blind searches of data from the Fermi Large Area Telescope (<span class="hlt">LAT</span>). The pulsars were found using a novel search approach, combining volunteer distributed computing via Einstein@Home and methods originally developed in gravitational-wave astronomy. The pulsars PSRs J0554+3107, J1422–6138, J1522–5735, and J1932+1916 are young and energetic, with characteristic ages between 35 and 56 kyr and spin-down powers in the range 6 × 10{sup 34}—10{sup 36} erg s{sup –1}. They are located in the Galactic plane and have rotation rates of less than 10 Hz, among which the 2.1 Hz spin frequency of PSR J0554+3107 ismore » the slowest of any known gamma-ray pulsar. For two of the new pulsars, we find supernova remnants coincident on the sky and discuss the plausibility of such associations. Deep radio follow-up observations found no pulsations, suggesting that all four pulsars are radio-quiet as viewed from Earth. These discoveries, the first gamma-ray pulsars found by volunteer computing, motivate continued blind pulsar searches of the many other unidentified <span class="hlt">LAT</span> gamma-ray sources.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22078321-radio-detection-fermi-lat-blind-search-millisecond-pulsar-j1311','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22078321-radio-detection-fermi-lat-blind-search-millisecond-pulsar-j1311"><span>RADIO DETECTION OF THE FERMI-<span class="hlt">LAT</span> BLIND SEARCH MILLISECOND PULSAR J1311-3430</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Ray, P. S.; Wood, K. S.; Ransom, S. M.</p> <p>2013-01-20</p> <p>We report the detection of radio emission from PSR J1311-3430, the first millisecond pulsar (MSP) discovered in a blind search of Fermi Large Area Telescope (<span class="hlt">LAT</span>) gamma-ray data. We detected radio pulsations at 2 GHz, visible for <10% of {approx}4.5 hr of observations using the Green Bank Telescope (GBT). Observations at 5 GHz with the GBT and at several lower frequencies with Parkes, Nancay, and the Giant Metrewave Radio Telescope resulted in non-detections. We also report the faint detection of a steep spectrum continuum radio source (0.1 mJy at 5 GHz) in interferometric imaging observations with the Jansky Very Largemore » Array. These detections demonstrate that PSR J1311-3430 is not radio quiet and provide additional evidence that radio-quiet MSPs are rare. The radio dispersion measure of 37.8 pc cm{sup -3} provides a distance estimate of 1.4 kpc for the system, yielding a gamma-ray efficiency of 30%, typical of <span class="hlt">LAT</span>-detected MSPs. We see apparent excess delay in the radio pulses as the pulsar appears from eclipse and we speculate on possible mechanisms for the non-detections of the pulse at other orbital phases and observing frequencies.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/28777601','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/28777601"><span>Diffuse Cosmic Rays Shining in the Galactic Center: A Novel Interpretation of H.E.S.S. and Fermi-<span class="hlt">LAT</span> γ-Ray Data.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gaggero, D; Grasso, D; Marinelli, A; Taoso, M; Urbano, A</p> <p>2017-07-21</p> <p>We present a novel interpretation of the γ-ray diffuse emission measured by Fermi-<span class="hlt">LAT</span> and H.E.S.S. in the Galactic center (GC) region and the Galactic ridge (GR). In the first part we perform a data-driven analysis based on PASS8 Fermi-<span class="hlt">LAT</span> data: We extend down to a few GeV the spectra measured by H.E.S.S. and infer the primary cosmic-ray (CR) radial distribution between 0.1 and 3 TeV. In the second part we adopt a CR transport model based on a position-dependent diffusion coefficient. Such behavior reproduces the radial dependence of the CR spectral index recently inferred from the Fermi-<span class="hlt">LAT</span> observations. We find that the bulk of the GR emission can be naturally explained by the interaction of the diffuse steady-state Galactic CR sea with the gas present in the central molecular zone. Although we confirm the presence of a residual radial-dependent emission associated with a central source, the relevance of the large-scale diffuse component prevents to claim a solid evidence of GC pevatrons.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018PhRvD..97h3007L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018PhRvD..97h3007L"><span>Study of the boxlike dark matter signals from dwarf spheroidal galaxies with Fermi-<span class="hlt">LAT</span> data</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Li, Shang; Liang, Yun-Feng; Xia, Zi-Qing; Zu, Lei; Duan, Kai-Kai; Shen, Zhao-Qiang; Feng, Lei; Yuan, Qiang; Fan, Yi-Zhong</p> <p>2018-04-01</p> <p>The observation of a special spectral feature in the gamma-ray data would be one of the best ways to identify dark matter (DM). The box-shaped gamma-ray spectra could be generated by the decay of intermediate particles produced by DM annihilation or decay. It provides another kind of signal that can be relatively easily distinguished from astrophysical backgrounds besides the linelike signals. Dwarf spheroidal galaxies are expected to be dominated by DM and may be one of the most promising targets for indirect DM searches. In this paper, we study the box-shaped DM signals with Fermi-<span class="hlt">LAT</span> observations of dwarf spheroidal galaxies. We analyze 106 months of Fermi-<span class="hlt">LAT</span> data to derive the upper limits on the annihilation cross section or the decay timescale of DM. In addition, we compare the results for different sample selections and DM density distributions. We expect that more dwarf spheroidal galaxies will be found and the sensitivity of box-shaped gamma-ray signal searches will be significantly improved in the future.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017MNRAS.470.1291S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017MNRAS.470.1291S"><span>3FGLzoo: classifying 3FGL unassociated Fermi-<span class="hlt">LAT</span> γ-ray sources by artificial neural networks</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Salvetti, D.; Chiaro, G.; La Mura, G.; Thompson, D. J.</p> <p>2017-09-01</p> <p>In its first four years of operation, the Fermi-Large Area Telescope (<span class="hlt">LAT</span>) detected 3033 γ-ray emitting sources. In the Fermi-<span class="hlt">LAT</span> Third Source Catalogue (3FGL) about 50 per cent of the sources have no clear association with a likely γ-ray emitter. We use an artificial neural network algorithm aimed at distinguishing BL Lacs from FSRQs to investigate the source subclass of 559 3FGL unassociated sources characterized by γ-ray properties very similar to those of active galactic nuclei. Based on our method, we can classify 271 objects as BL Lac candidates, 185 as FSRQ candidates, leaving only 103 without a clear classification. We suggest a new zoo for γ-ray objects, where the percentage of sources of uncertain type drops from 52 per cent to less than 10 per cent. The result of this study opens up new considerations on the population of the γ-ray sky, and it will facilitate the planning of significant samples for rigorous analyses and multiwavelength observational campaigns.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1051385','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1051385"><span>Search for Large Extra Dimensions Based on Observations of Neutron Stars with the Fermi-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Berenji, Bijan</p> <p></p> <p>Large extra dimensions (LED) have been proposed to account for the apparent weakness of gravitation. These theories also indicate that the postulated massive Kaluza-Klein (KK) gravitons may be produced by nucleon-nucleon bremsstrahlung in the course of core collapse of supernovae. Hannestad and Raffelt have predicted energy spectra of gamma ray emission from the decay of KK gravitons trapped by the gravity of the remnant neutron stars (NS). These and other authors have used EGRET data on NS to obtain stringent limits on LED. Fermi-<span class="hlt">LAT</span> is observing radio pulsar positions obtained from radio and x-ray catalogs. NS with certain characteristics aremore » unlikely emitter of gamma rays, and emit in radio and perhaps x-rays. This talk will focus on the blind analysis we plan to perform, which has been developed using the 1st 2 months of all sky data and Monte Carlo simulations, to obtain limits on LED based on about 1 year of Fermi-<span class="hlt">LAT</span> data. Preliminary limits from this analysis using these first 2 months of data will be also be discussed.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014JHEP...09..120C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014JHEP...09..120C"><span>Inert dark matter in type-II seesaw</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Chen, Chuan-Hung; Nomura, Takaaki</p> <p>2014-09-01</p> <p>Weakly interacting massive particle (WIMP) as a dark matter (DM) candidate is further inspired by recent AMS-02 data, which confirm the excess of positron fraction observed earlier by PAMELA and Fermi-<span class="hlt">LAT</span> experiments. Additionally, the excess of positron+<span class="hlt">electron</span> <span class="hlt">flux</span> is still significant in the measurement of Fermi-<span class="hlt">LAT</span>. For solving the problems of massive neutrinos and observed excess of cosmic-ray, we study the model with an inert Higgs doublet (IHD) in the framework of type-II seesaw model by imposing a Z 2 symmetry on the IHD, where the lightest particle of IHD is the DM candidate and the neutrino masses originate from the Yukawa couplings of Higgs triplet and leptons. We calculate the cosmic-ray production in our model by using three kinds of neutrino mass spectra, which are classified by normal ordering, inverted ordering and quasi-degeneracy. We find that when the constraints of DM relic density and comic-ray antiproton spectrum are taken into account, the observed excess of positron/<span class="hlt">electron</span> <span class="hlt">flux</span> could be explained well in normal ordered neutrino mass spectrum. Moreover, excess of comic-ray neutrinos is implied in our model. We find that our results on < σv> are satisfied with and close to the upper limit of IceCube analysis. More data from comic-ray neutrinos could test our model.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018GeoRL..45.3768M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018GeoRL..45.3768M"><span>Evidence for Neutrals-Foreshock <span class="hlt">Electrons</span> Impact at Mars</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Mazelle, C. X.; Meziane, K.; Mitchell, D. L.; Garnier, P.; Espley, J. R.; Hamza, A. M.; Halekas, J.; Jakosky, B. M.</p> <p>2018-05-01</p> <p>Backstreaming <span class="hlt">electrons</span> emanating from the bow shock of Mars reported from the Mars Atmosphere and Volatile EvolutioN/Solar Wind <span class="hlt">Electron</span> Analyzer observations show a <span class="hlt">flux</span> fall off with the distance from the shock. This feature is not observed at the terrestrial foreshock. The <span class="hlt">flux</span> decay is observed only for <span class="hlt">electron</span> energy E ≥ 29 eV. A reported recent study indicates that Mars foreshock <span class="hlt">electrons</span> are produced at the shock in a mirror reflection of a portion of the solar wind <span class="hlt">electrons</span>. In this context, and given that the <span class="hlt">electrons</span> are sufficiently energetic to not be affected by the interplanetary magnetic field fluctuations, the observed <span class="hlt">flux</span> decrease appears problematic. We investigate the possibility that the <span class="hlt">flux</span> fall off with distance results from the impact of backstreaming <span class="hlt">electrons</span> with Mars exospheric neutral hydrogen. We demonstrate that the <span class="hlt">flux</span> fall off is consistent with the <span class="hlt">electron</span>-atomic hydrogen impact cross section for a large range of energy. A better agreement is obtained for energy where the impact cross section is the highest. One important consequence is that foreshock <span class="hlt">electrons</span> can play an important role in the production of pickup ions at Mars far exosphere.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21282515','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21282515"><span>Role of two adaptor molecules SLP-76 and <span class="hlt">LAT</span> in the PI3K signaling pathway in activated T cells.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Shim, Eun Kyung; Jung, Seung Hee; Lee, Jong Ran</p> <p>2011-03-01</p> <p>Previously, we identified p85, a subunit of PI3K, as one of the molecules that interacts with the N-terminal region of Src homology 2 domain-containing leukocyte protein of 76 kDa (SLP-76). We also demonstrated that tyrosine phosphorylation either at the 113 and/or 128 position is sufficient for the association of SLP-76 with the Src homology 2 domain near the N terminus of p85. The present study further examines the role of the association of these two molecules on the activation of PI3K signaling cascade. Experiments were done to determine the role of SLP-76, either wild-type, tyrosine mutants, or membrane-targeted forms of various SLP-76 constructs, on the membrane localization and phosphorylation of Akt, which is an event downstream of PI3K activation. Reconstitution studies with these various SLP-76 constructs in a Jurkat variant cell line that lacks SLP-76 or linker for activation of T cells (<span class="hlt">LAT</span>) show that the activation of PI3K pathway following TCR ligation requires both SLP-76 and <span class="hlt">LAT</span> adaptor proteins. The results suggest that SLP-76 associates with p85 after T cell activation and that <span class="hlt">LAT</span> recruits this complex to the membrane, leading to Akt activation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19850026433','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19850026433"><span>Two types of <span class="hlt">electron</span> events in solar flares</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Daibog, E. I.; Kurt, V. G.; Logachev, Y. I.; Stolpovsky, V. G.</p> <p>1985-01-01</p> <p>The <span class="hlt">fluxes</span> and spectra of the flare <span class="hlt">electrons</span> measured on board Venera-I3 and I4 space probes are compared with the parameters of the hard (E sub x approximately 55 keV) and thermal X-ray bursts. The <span class="hlt">electron</span> <span class="hlt">flux</span> amplitude has been found to correlate with flare importance in the thermal X-ray range (r approximately 0.8). The following two types of flare events have been found in the <span class="hlt">electron</span> component of SCR. The <span class="hlt">electron</span> <span class="hlt">flux</span> increase is accompanied by a hard X-ray burst and the <span class="hlt">electron</span> spectrum index in the approximately 25 to 200 keV energy range is gamma approximately 2 to 3. The <span class="hlt">electron</span> <span class="hlt">flux</span> increase is not accompanied by a hard X-ray burst and the <span class="hlt">electron</span> spectrum is softer (Delta gamma approximately 0.7 to 1.0).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20170003543&hterms=fisica&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3Dfisica','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20170003543&hterms=fisica&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3Dfisica"><span>Deep Morphological and Spectral Study of the SNR RCW 86 with Fermi-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ajello, M.; Baldini, L.; Barbiellini, G.; Bastieri, D.; Bellazzini, R.; Bissaldi, E.; Bloom, E. D.; Bonino, R.; Bottacini, E.; Brandt, T. J.; <a style="text-decoration: none; " href="javascript:void(0); " onClick="displayelement('author_20170003543'); toggleEditAbsImage('author_20170003543_show'); toggleEditAbsImage('author_20170003543_hide'); "> <img style="display:inline; width:12px; height:12px; " src="images/arrow-up.gif" width="12" height="12" border="0" alt="hide" id="author_20170003543_show"> <img style="width:12px; height:12px; display:none; " src="images/arrow-down.gif" width="12" height="12" border="0" alt="hide" id="author_20170003543_hide"></p> <p>2016-01-01</p> <p>RCW 86 is a young supernova remnant (SNR) showing a shell-type structure at several wavelengths and is thought to be an efficient cosmic-ray (CR) accelerator. Earlier Fermi Large Area Telescope results reported the detection of gamma-ray emission coincident with the position of RCW 86 but its origin (leptonic or hadronic) remained unclear due to the poor statistics. Thanks to 6.5 years of data acquired by the Fermi-<span class="hlt">LAT</span> and the new event reconstruction Pass 8, we report the significant detection of spatially extended emission coming from RCW 86. The spectrum is described by a power-law function with a very hard photon index (Gamma = 1.42 +/- 0.1(sub stat) +/- 0.06(sub syst)) in the 0.1-500 GeV range and an energy <span class="hlt">flux</span> above 100 MeV of (2.91 +/- 0.8(sub stat) +/- 0.12(sub syst)) x 10(exp -11) erg/(sq cms). Gathering all the available multiwavelength (MWL) data, we perform a broadband modeling of the non-thermal emission of RCW 86 to constrain parameters of the nearby medium and bring new hints about the origin of the gamma-ray emission. For the whole SNR, the modeling favors a leptonic scenario in the framework of a two-zone model with an average magnetic field of 10.2 +/- 0.7 microG and a limit on the maximum energy injected into protons of 2 x 10(exp 49) erg for a density of 1 per cu cm. In addition, parameter values are derived for the north-east and south-west (SW) regions of RCW 86, providing the first indication of a higher magnetic field in the SW region.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/19238334','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/19238334"><span>The expression of COX-2, hTERT, MDM2, <span class="hlt">LATS</span>2 and S100A2 in different types of non-small cell lung cancer (NSCLC).</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Strazisar, Mojca; Mlakar, Vid; Glavac, Damjan</p> <p>2009-01-01</p> <p>Several studies have reported different expression levels of certain genes in NSCLC, mostly related to the stage and advancement of the tumours. We investigated 65 stage I-III NSCLC tumours: 32 adenocarcinomas (ADC), 26 squamous cell carcinomas (SCC) and 7 large cell carcinomas (LCC). Using the real-time reverse transcription polymerase chain reaction (RT-PCR), we analysed the expression of the COX-2, hTERT, MDM2, <span class="hlt">LATS</span>2 and S100A2 genes and researched the relationships between the NSCLC types and the differences in expression levels. The differences in the expression levels of the <span class="hlt">LATS</span>2, S100A2 and hTERT genes in different types of NSCLC are significant. hTERT and COX-2 were over-expressed and <span class="hlt">LATS</span>2 under-expressed in all NSCLC. We also detected significant relative differences in the expression of <span class="hlt">LATS</span>2 and MDM2, hTERT and MDM2 in different types of NSCLC. There was a significant difference in the average expression levels in S100A2 for ADC and SCC. Our study shows differences in the expression patterns within the NSCLC group, which may mimic the expression of the individual NSCLC type, and also new relationships in the expression levels for different NSCLC types.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JGRA..122.1531M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JGRA..122.1531M"><span>Martian <span class="hlt">electron</span> foreshock from MAVEN observations</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Meziane, K.; Mazelle, C. X.; Romanelli, N.; Mitchell, D. L.; Espley, J. R.; Connerney, J. E. P.; Hamza, A. M.; Halekas, J.; McFadden, J. P.; Jakosky, B. M.</p> <p>2017-02-01</p> <p><span class="hlt">Flux</span> enhancements of energetic <span class="hlt">electrons</span> are always observed when the Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft is magnetically connected to the shock. The observations indicate that the foreshock <span class="hlt">electrons</span> consist of two populations. The most energetic (E≥237 eV) originate from a narrow region at the nearly perpendicular shock. They always appear as spikes, and their <span class="hlt">flux</span> level reaches a maximum when the angle θBn approaches 90°. The other population emanates from the entire Martian bow shock surface, and the <span class="hlt">flux</span> level decreases slightly from the quasi-parallel to quasi-perpendicular regions. A detailed examination of the pitch angle distribution shows that the enhanced <span class="hlt">fluxes</span> are associated with <span class="hlt">electrons</span> moving sunward. Annulus centered along the interplanetary magnetic field direction is the most stringent feature of the 3-D angular distribution. The gyrotropic character is observed over the whole range of shock geometry. Although such signatures in the <span class="hlt">electron</span> pitch angle distribution function strongly suggest that the reflection off the shock of a fraction of the solar wind <span class="hlt">electrons</span> is the main mechanism for the production of Martian foreshock <span class="hlt">electrons</span>, the decay of the <span class="hlt">flux</span> of the second population on the other hand has yet to be understood.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_22 --> <div id="page_23" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="441"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014AGUFMSM51A4236K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014AGUFMSM51A4236K"><span>Relationship between Relativistic <span class="hlt">Electron</span> <span class="hlt">Flux</span> in the Inner Magnetosphere and ULF Pulsation on the Ground Associated with Long-term Variations of Solar Wind</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kitamura, K.; Nagatsuma, T.; Troshichev, O. A.; Obara, T.; Koshiishi, H.; Saita, S.; Yoshikawa, A.; Yumoto, K.</p> <p>2014-12-01</p> <p>In the present study the relativistic <span class="hlt">electron</span> <span class="hlt">flux</span> (0.59-1.18MeV) measured by Standard Dose Monitor (SDOM) onboard DRTS (KODAMA) satellite at the Geostationary Earth Orbit (GEO) is analyzed to investigate the long term (from 2002 to 2014) variations of the <span class="hlt">electron</span> <span class="hlt">flux</span> enhancement (REF) during the passage of Corotating Interaction Regions (CIRs) and/or Coronal Mass Ejection (CMEs). The long term variations of the REF clearly shows the 27-days period associated with the high speed solar wind velocity caused by the CIRs, whereas it is very few that the enhancement of REF lasts for several days after passage of CMEs. The 27-days period enhancement of REF represents the quite strong peak in 2003 when the high speed stream of the solar wind were quit active. We also conducted the same analysis for the Pc5 pulsations observed on the ground. The ground magnetic variations data globally observed by National Institute of Information and Communications Technology (NICT) and International Center for Space Weather Science and Education (ICSWSE) Kyushu University are used to investigate the long term variations of Pc5 power. The same signature in the REF variations is shown in the time variability of the Pc5 power on the ground. These results indicate that the solar wind condition strongly affects the acceleration process of the relativistic <span class="hlt">electron</span> <span class="hlt">flux</span> by the ULF wave. In particular the dependence of the REF and Pc5 variations on the sector structures and their seasonal variations strongly suggest that the relationship between Pc5 and REF variations could be controlled by the Russell-McPherron effect.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20070034013','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20070034013"><span>The Synergy between the <span class="hlt">LAT</span> and GBM in GLAST's Study of Gamma-Ray Bursts</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Band, David L.</p> <p>2007-01-01</p> <p>Using semi-analytic calculations I characterize the gamma-ray bursts to which GLAST's <span class="hlt">LAT</span> and GBM detectors will be sensitive. The thresholds of both instruments are at approximately the same vfv proportional to E(sup 2)N(E) values, i.e., the thresholds can be connected by an E(sup -2) spectrum. Therefore simultaneous detections by both instruments will be biased towards spectral components flatter than E(sup -2).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1356603-radio-detection-fermi-lat-blind-search-millisecond-pulsar-j13113430','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1356603-radio-detection-fermi-lat-blind-search-millisecond-pulsar-j13113430"><span>Radio Detection of the FERMI-<span class="hlt">LAT</span> Blind Search Millisecond Pulsar J1311–3430</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Ray, P. S.; Ransom, S. M.; Cheung, C. C.; ...</p> <p>2013-01-02</p> <p>In this article, we report the detection of radio emission from PSR J1311–3430, the first millisecond pulsar (MSP) discovered in a blind search of Fermi Large Area Telescope (<span class="hlt">LAT</span>) gamma-ray data. We detected radio pulsations at 2 GHz, visible for <10% of ~4.5 hr of observations using the Green Bank Telescope (GBT). Observations at 5 GHz with the GBT and at several lower frequencies with Parkes, Nançay, and the Giant Metrewave Radio Telescope resulted in non-detections. We also report the faint detection of a steep spectrum continuum radio source (0.1 mJy at 5 GHz) in interferometric imaging observations with themore » Jansky Very Large Array. These detections demonstrate that PSR J1311–3430 is not radio quiet and provide additional evidence that radio-quiet MSPs are rare. The radio dispersion measure of 37.8 pc cm –3 provides a distance estimate of 1.4 kpc for the system, yielding a gamma-ray efficiency of 30%, typical of <span class="hlt">LAT</span>-detected MSPs. Lastly, we see apparent excess delay in the radio pulses as the pulsar appears from eclipse and we speculate on possible mechanisms for the non-detections of the pulse at other orbital phases and observing frequencies.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1328739-runaway-electrons-magnetic-island-confinement','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1328739-runaway-electrons-magnetic-island-confinement"><span>Runaway <span class="hlt">electrons</span> and magnetic island confinement</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Boozer, Allen H.</p> <p>2016-08-19</p> <p>The breakup of magnetic surfaces is a central feature of ITER planning for the avoidance of damage due to runaway <span class="hlt">electrons</span>. Rapid thermal quenches, which lead to large accelerating voltages, are thought to be due to magnetic surface breakup. Impurity injection to avoid and to mitigate both halo and runaway <span class="hlt">electron</span> currents utilizes massive gas injection or shattered pellets. The actual deposition is away from the plasma center, and the breakup of magnetic surfaces is thought to spread the effects of the impurities across the plasma cross section. The breakup of magnetic surfaces would prevent runaway <span class="hlt">electrons</span> from reaching relativisticmore » energies were it not for the persistence of non-intercepting <span class="hlt">flux</span> tubes. These are tubes of magnetic field lines that do not intercept the walls. In simulations and in magnetic field models, non-intercepting <span class="hlt">flux</span> tubes are found to persist near the magnetic axis and in the cores of magnetic islands even when a large scale magnetic surface breakup occurs. As long as a few magnetic surfaces reform before all of the non-intercepting <span class="hlt">flux</span> tubes dissipate, energetic <span class="hlt">electrons</span> confined and accelerated in these <span class="hlt">flux</span> tubes can serve as the seed <span class="hlt">electrons</span> for a transfer of the overall plasma current from thermal to relativistic carriers. The acceleration of <span class="hlt">electrons</span> is particularly strong because of the sudden changes in the poloidal <span class="hlt">flux</span> that naturally occur in a rapid magnetic relaxation. Furthermore, the physics of magnetic islands as non-intercepting <span class="hlt">flux</span> tubes is studied. Expressions are derived for (1) the size of islands required to confine energetic runaway <span class="hlt">electrons</span>, (2) the accelerating electric field in an island, (3) the increase or reduction in the size of an island by the runaway <span class="hlt">electron</span> current, (4) the approximate magnitude of the runaway current in an island, and (5) the time scale for the evolution of an island.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22599889-runaway-electrons-magnetic-island-confinement','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22599889-runaway-electrons-magnetic-island-confinement"><span>Runaway <span class="hlt">electrons</span> and magnetic island confinement</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Boozer, Allen H., E-mail: ahb17@columbia.edu</p> <p></p> <p>The breakup of magnetic surfaces is a central feature of ITER planning for the avoidance of damage due to runaway <span class="hlt">electrons</span>. Rapid thermal quenches, which lead to large accelerating voltages, are thought to be due to magnetic surface breakup. Impurity injection to avoid and to mitigate both halo and runaway <span class="hlt">electron</span> currents utilizes massive gas injection or shattered pellets. The actual deposition is away from the plasma center, and the breakup of magnetic surfaces is thought to spread the effects of the impurities across the plasma cross section. The breakup of magnetic surfaces would prevent runaway <span class="hlt">electrons</span> from reaching relativisticmore » energies were it not for the persistence of non-intercepting <span class="hlt">flux</span> tubes. These are tubes of magnetic field lines that do not intercept the walls. In simulations and in magnetic field models, non-intercepting <span class="hlt">flux</span> tubes are found to persist near the magnetic axis and in the cores of magnetic islands even when a large scale magnetic surface breakup occurs. As long as a few magnetic surfaces reform before all of the non-intercepting <span class="hlt">flux</span> tubes dissipate, energetic <span class="hlt">electrons</span> confined and accelerated in these <span class="hlt">flux</span> tubes can serve as the seed <span class="hlt">electrons</span> for a transfer of the overall plasma current from thermal to relativistic carriers. The acceleration of <span class="hlt">electrons</span> is particularly strong because of the sudden changes in the poloidal <span class="hlt">flux</span> that naturally occur in a rapid magnetic relaxation. The physics of magnetic islands as non-intercepting <span class="hlt">flux</span> tubes is studied. Expressions are derived for (1) the size of islands required to confine energetic runaway <span class="hlt">electrons</span>, (2) the accelerating electric field in an island, (3) the increase or reduction in the size of an island by the runaway <span class="hlt">electron</span> current, (4) the approximate magnitude of the runaway current in an island, and (5) the time scale for the evolution of an island.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1328739','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1328739"><span>Runaway <span class="hlt">electrons</span> and magnetic island confinement</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Boozer, Allen H.</p> <p></p> <p>The breakup of magnetic surfaces is a central feature of ITER planning for the avoidance of damage due to runaway <span class="hlt">electrons</span>. Rapid thermal quenches, which lead to large accelerating voltages, are thought to be due to magnetic surface breakup. Impurity injection to avoid and to mitigate both halo and runaway <span class="hlt">electron</span> currents utilizes massive gas injection or shattered pellets. The actual deposition is away from the plasma center, and the breakup of magnetic surfaces is thought to spread the effects of the impurities across the plasma cross section. The breakup of magnetic surfaces would prevent runaway <span class="hlt">electrons</span> from reaching relativisticmore » energies were it not for the persistence of non-intercepting <span class="hlt">flux</span> tubes. These are tubes of magnetic field lines that do not intercept the walls. In simulations and in magnetic field models, non-intercepting <span class="hlt">flux</span> tubes are found to persist near the magnetic axis and in the cores of magnetic islands even when a large scale magnetic surface breakup occurs. As long as a few magnetic surfaces reform before all of the non-intercepting <span class="hlt">flux</span> tubes dissipate, energetic <span class="hlt">electrons</span> confined and accelerated in these <span class="hlt">flux</span> tubes can serve as the seed <span class="hlt">electrons</span> for a transfer of the overall plasma current from thermal to relativistic carriers. The acceleration of <span class="hlt">electrons</span> is particularly strong because of the sudden changes in the poloidal <span class="hlt">flux</span> that naturally occur in a rapid magnetic relaxation. Furthermore, the physics of magnetic islands as non-intercepting <span class="hlt">flux</span> tubes is studied. Expressions are derived for (1) the size of islands required to confine energetic runaway <span class="hlt">electrons</span>, (2) the accelerating electric field in an island, (3) the increase or reduction in the size of an island by the runaway <span class="hlt">electron</span> current, (4) the approximate magnitude of the runaway current in an island, and (5) the time scale for the evolution of an island.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015SpWea..13...16G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015SpWea..13...16G"><span>Nowcast model for low-energy <span class="hlt">electrons</span> in the inner magnetosphere</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ganushkina, N. Yu.; Amariutei, O. A.; Welling, D.; Heynderickx, D.</p> <p>2015-01-01</p> <p>We present the nowcast model for low-energy (<200 keV) <span class="hlt">electrons</span> in the inner magnetosphere, which is the version of the Inner Magnetosphere Particle Transport and Acceleration Model (IMPTAM) for <span class="hlt">electrons</span>. Low-energy <span class="hlt">electron</span> <span class="hlt">fluxes</span> are very important to specify when hazardous satellite surface-charging phenomena are considered. The presented model provides the low-energy <span class="hlt">electron</span> <span class="hlt">flux</span> at all L shells and at all satellite orbits, when necessary. The model is driven by the real-time solar wind and interplanetary magnetic field (IMF) parameters with 1 h time shift for propagation to the Earth's magnetopause and by the real time Dst index. Real-time geostationary GOES 13 or GOES 15 (whenever each is available) data on <span class="hlt">electron</span> <span class="hlt">fluxes</span> in three energies, such as 40 keV, 75 keV, and 150 keV, are used for comparison and validation of IMPTAM running online. On average, the model provides quite reasonable agreement with the data; the basic level of the observed <span class="hlt">fluxes</span> is reproduced. The best agreement between the modeled and the observed <span class="hlt">fluxes</span> are found for <100 keV <span class="hlt">electrons</span>. At the same time, not all the peaks and dropouts in the observed <span class="hlt">electron</span> <span class="hlt">fluxes</span> are reproduced. For 150 keV <span class="hlt">electrons</span>, the modeled <span class="hlt">fluxes</span> are often smaller than the observed ones by an order of magnitude. The normalized root-mean-square deviation is found to range from 0.015 to 0.0324. Though these metrics are buoyed by large standard deviations, owing to the dynamic nature of the <span class="hlt">fluxes</span>, they demonstrate that IMPTAM, on average, predicts the observed <span class="hlt">fluxes</span> satisfactorily. The computed binary event tables for predicting high <span class="hlt">flux</span> values within each 1 h window reveal reasonable hit rates being 0.660-0.318 for <span class="hlt">flux</span> thresholds of 5 ·104-2 ·105 cm-2 s-1 sr-1 keV-1 for 40 keV <span class="hlt">electrons</span>, 0.739-0.367 for <span class="hlt">flux</span> thresholds of 3 ·104-1 ·105 cm-2 s-1 sr-1 keV-1 for 75 keV <span class="hlt">electrons</span>, and 0.485-0.438 for <span class="hlt">flux</span> thresholds of 3 ·103-3.5 ·103 cm-2 s-1 sr-1 keV-1 for 150 keV <span class="hlt">electrons</span> but rather small Heidke</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016ApPhA.122..650B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016ApPhA.122..650B"><span><span class="hlt">Flux</span> growth and characterization of cuprorivaite: the influence of temperature, <span class="hlt">flux</span>, and silica source</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bloise, A.; Abd El Salam, S.; De Luca, R.; Crisci, G. M.; Miriello, D.</p> <p>2016-07-01</p> <p>Single crystals of cuprorivaite (CaCuSi4O10), one of the oldest synthetic color pigments of Egyptian history, have been synthesized by slow-cooling <span class="hlt">flux</span> method. Several runs were carried out at temperatures between 800 and 960 °C and with reaction times ranging from 10 to 72 h. The starting materials and run products were characterized by binocular microscope, X-ray powder diffraction, scanning <span class="hlt">electron</span> microscopy with annexed energy-dispersive spectrometry, and μ-Raman spectroscopy. The effects of growth parameters (temperature, <span class="hlt">flux</span>, silica source) on yield and size of crystals were studied. The growth of cuprorivaite depends greatly on the starting materials: they are observed as run products only using natron as <span class="hlt">flux</span>. Furthermore, colorimetric analysis performed on the synthesizing pigment was compared with the archeological samples present in the literature in order to value similarities and differences.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017AGUFMSM11A2286T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017AGUFMSM11A2286T"><span>The Role of Kinetic Alfven Waves in Plasma Transport in an Ion-scale <span class="hlt">Flux</span> Rope</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Tang, B.; Li, W.; Wang, C.; Dai, L.</p> <p>2017-12-01</p> <p>Magnetic <span class="hlt">flux</span> ropes, if generated by multiply X-line reconnections, would be born as a crater type one, meaning the plasma density within is relatively high. They will then evolve into typical <span class="hlt">flux</span> ropes as plasma are transported away along the magnetic field lines [Zhang et al., 2010]. In this study, we report an ion-scale <span class="hlt">flux</span> rope observed by MMS on November 28, 2016, which is accompanied by strong kinetic Alfven waves (KAW). The related wave parallel electric field can effectively accelerate <span class="hlt">electrons</span> inside the <span class="hlt">flux</span> rope by Landau resonance, resulting into a significant decrease of the <span class="hlt">electron</span> at 90° pitch angle. The change of <span class="hlt">electron</span> pitch angle distribution would cause the rapid plasma transport along the magnetic field lines, and help the <span class="hlt">flux</span> rope evolve into a strong magnetic core in a short time. This wave-particle interaction would be a candidate mechanism to explain the rareness of crater <span class="hlt">flux</span> ropes in reality.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title50-vol13/pdf/CFR-2014-title50-vol13-part660-app1c.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title50-vol13/pdf/CFR-2014-title50-vol13-part660-app1c.pdf"><span>50 CFR Table 1c to Part 660... - Sablefish North of 36° N. <span class="hlt">lat</span>. Allocations, 2013</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Sablefish North of 36° N. <span class="hlt">lat</span>. Allocations, 2013 1c Table 1c to Part 660, Subpart C Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JAP...122j3301Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JAP...122j3301Z"><span><span class="hlt">Electron</span> kinetics in capacitively coupled plasmas modulated by <span class="hlt">electron</span> injection</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zhang, Ya; Peng, Yanli; Innocenti, Maria Elena; Jiang, Wei; Wang, Hong-yu; Lapenta, Giovanni</p> <p>2017-09-01</p> <p>The controlling effect of an <span class="hlt">electron</span> injection on the <span class="hlt">electron</span> energy distribution function (EEDF) and on the energetic <span class="hlt">electron</span> <span class="hlt">flux</span>, in a capacitive radio-frequency argon plasma, is studied using a one-dimensional particle-in-cell/Monte Carlo collisions model. The input power of the <span class="hlt">electron</span> beam is as small as several tens of Watts with laboratory achievable emission currents and energies. With the <span class="hlt">electron</span> injection, the <span class="hlt">electron</span> temperature decreases but with a significant high energy tail. The <span class="hlt">electron</span> density, <span class="hlt">electron</span> temperature in the sheath, and <span class="hlt">electron</span> heating rate increase with the increasing emission energy. This is attributed to the extra heating of the energetic <span class="hlt">electrons</span> in the EEDF tail. The non-equilibrium EEDF is obtained for strong non-local distributions of the electric field, <span class="hlt">electron</span> heating rate, excitation, and ionization rate, indicating the discharge has transited from a volume heating (α-mode dominated) into a sheath heating (γ-mode dominated) type. In addition, the <span class="hlt">electron</span> injection not only modifies the self-bias voltage, but also enhances the <span class="hlt">electron</span> <span class="hlt">flux</span> that can reach the electrodes. Moreover, the relative population of energetic <span class="hlt">electrons</span> significantly increases with the <span class="hlt">electron</span> injection compared to that without the <span class="hlt">electron</span> injection, relevant for modifying the gas and surface chemistry reactions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20040081418','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20040081418"><span>Radiation Dose from Reentrant <span class="hlt">Electrons</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Badhwar, G.D.; Cleghorn, T. E.; Watts, J.</p> <p>2003-01-01</p> <p>In estimating the crew exposures during an EVA, the contribution of reentrant <span class="hlt">electrons</span> has always been neglected. Although the <span class="hlt">flux</span> of these <span class="hlt">electrons</span> is small compared to the <span class="hlt">flux</span> of trapped <span class="hlt">electrons</span>, their energy spectrum extends to several GeV compared to about 7 MeV for trapped <span class="hlt">electrons</span>. This is also true of splash <span class="hlt">electrons</span>. Using the measured reentrant <span class="hlt">electron</span> energy spectra, it is shown that the dose contribution of these <span class="hlt">electrons</span> to the blood forming organs (BFO) is more than 10 times greater than that from the trapped <span class="hlt">electrons</span>. The calculations also show that the dose-depth response is a very slowly changing function of depth, and thus adding reasonable amounts of additional shielding would not significantly lower the dose to BFO.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2018JEMat..47.3254M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2018JEMat..47.3254M"><span>High-Throughput Screening of Sulfide Thermoelectric Materials Using <span class="hlt">Electron</span> Transport Calculations with OpenMX and BoltzTraP</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Miyata, Masanobu; Ozaki, Taisuke; Takeuchi, Tsunehiro; Nishino, Shunsuke; Inukai, Manabu; Koyano, Mikio</p> <p>2018-06-01</p> <p>The <span class="hlt">electron</span> transport properties of 809 sulfides have been investigated using density functional theory (DFT) calculations in the relaxation time approximation, and a material design rule established for high-performance sulfide thermoelectric (TE) materials. Benchmark <span class="hlt">electron</span> transport calculations were performed for Cu12Sb4S13 and Cu26V2Ge6S32, revealing that the ratio of the scattering probability of <span class="hlt">electrons</span> and phonons ( κ <span class="hlt">lat</span> τ el -1 ) was constant at about 2 × 1014 W K-1 m-1 s-1. The calculated thermopower S dependence of the theoretical dimensionless figure of merit ZT DFT of the 809 sulfides showed a maximum at 140 μV K-1 to 170 μV K-1. Under the assumption of constant κ <span class="hlt">lat</span> τ el -1 of 2 × 1014 W K-1 m-1 s-1 and constant group velocity v of <span class="hlt">electrons</span>, a slope of the density of states of 8.6 states eV-2 to 10 states eV-2 is suitable for high- ZT sulfide TE materials. The Lorenz number L dependence of ZT DFT for the 809 sulfides showed a maximum at L of approximately 2.45 × 10-8 V2 K-2. This result demonstrates that the potential of high- ZT sulfide materials is highest when the <span class="hlt">electron</span> thermal conductivity κ el of the symmetric band is equal to that of the asymmetric band.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20110020749','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20110020749"><span>New Theoretical Estimates of the Contribution of Unresolved Star-Forming Galaxies to the Extragalactic Gamma-Ray Background (EGB) as Measured by EGRET and the Fermi-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Venters, Tonia M.</p> <p>2011-01-01</p> <p>We present new theoretical estimates of the contribution of unresolved star-forming galaxies to the extragalactic gamma-ray background (EGB) as measured by EGRET and the Fermi-<span class="hlt">LAT</span>. We employ several methods for determining the star-forming galaxy contribution the the EGB, including a method positing a correlation between the gamma-ray luminosity of a galaxy and its rate of star formation as calculated from the total infrared luminosity, and a method that makes use of a model of the evolution of the galaxy gas mass with cosmic time. We find that depending on the model, unresolved star-forming galaxies could contribute significantly to the EGB as measured by the Fermi-<span class="hlt">LAT</span> at energies between approx. 300 MeV and approx. few GeV. However, the overall spectrum of unresolved star-forming galaxies can explain neither the EGRET EGB spectrum at energies between 50 and 200 MeV nor the Fermi-<span class="hlt">LAT</span> EGB spectrum at energies above approx. few GeV.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JGRA..12212274S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JGRA..12212274S"><span><span class="hlt">Flux</span> Enhancements of > 30 keV <span class="hlt">Electrons</span> at Low Drift Shells L < 1.2 During Last Solar Cycles</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Suvorova, A. V.</p> <p>2017-12-01</p> <p>We present results of statistical analysis of enhancements of >30 keV <span class="hlt">electrons</span> observed by the NOAA/POES satellites during solar cycles 23 and 24 (1998-2016) at low drift shells L < 1.2, so-called forbidden zone. We collected 1,750 days ( 25% of the total time) when <span class="hlt">fluxes</span> of the forbidden energetic <span class="hlt">electrons</span> (FEE) exceeded 103 (cm2 s sr)-1. We found 530 days, when FEE <span class="hlt">fluxes</span> reached high intensity from 104 up to 107 (cm2 s sr)-1. It was found that the FEE enhancements were observed mostly often at the declining phases and solar minimum. More than 85% of the events occurred under fast solar wind (V > 450 km/s), high substorm activity (AL >150 nT), and enhanced interplanetary electric field perturbations (VδB > 1.5 mV/m). The FEE occurrence rate peaks around the local midnight. We have also found a quite unexpected annual variation of the FEE occurrence rate with a pronounced maximum from May to September, a minor peak in December-January, and minima at the equinoxes. The May-September peak, persisting at different solar cycle phases, was assumed to originate from high conductivity in the auroral ionosphere, which is controlled by the dipole tilt angle and provides better conditions for penetration of electric field perturbations into the inner magnetosphere. This allows explanation of the shape and amplitude of annual variation in the FEE occurrence rate from the convolution of the solar wind driver with the penetration conditions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/21736290','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/21736290"><span>QTAIM charge-charge <span class="hlt">flux</span>-dipole <span class="hlt">flux</span> interpretation of electronegativity and potential models of the fluorochloromethane mean dipole moment derivatives.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Silva, Arnaldo F; da Silva, João V; Haiduke, R L A; Bruns, Roy E</p> <p>2011-11-17</p> <p>Infrared fundamental vibrational intensities and quantum theory atoms in molecules (QTAIM) charge-charge <span class="hlt">flux</span>-dipole <span class="hlt">flux</span> (CCFDF) contributions to the polar tensors of the fluorochloromethanes have been calculated at the QCISD/cc-pVTZ level. A root-mean-square error of 20.0 km mol(-1) has been found compared to an experimental error estimate of 14.4 and 21.1 km mol(-1) for MP2/6-311++G(3d,3p) results. The errors in the QCISD polar tensor elements and mean dipole moment derivatives are 0.059 e when compared with the experimental values. Both theoretical levels provide results showing that the dynamical charge and dipole <span class="hlt">fluxes</span> provide significant contributions to the mean dipole moment derivatives and tend to be of opposite signs canceling one another. Although the experimental mean dipole moment derivative values suggest that all the fluorochloromethane molecules have <span class="hlt">electronic</span> structures consistent with a simple electronegativity model with transferable atomic charges for their terminal atoms, the QTAIM/CCFDF models confirm this only for the fluoromethanes. Whereas the fluorine atom does not suffer a saturation effect in its capacity to drain <span class="hlt">electronic</span> charge from carbon atoms that are attached to other fluorine and chlorine atoms, the zero <span class="hlt">flux</span> <span class="hlt">electronic</span> charge of the chlorine atom depends on the number and kind of the other substituent atoms. Both the QTAIM carbon charges (r = 0.990) and mean dipole moment derivatives (r = 0.996) are found to obey Siegbahn's potential model for carbon 1s <span class="hlt">electron</span> ionization energies at the QCISD/cc-pVTZ level. The latter is a consequence of the carbon mean derivatives obeying the electronegativity model and not necessarily to their similarities with atomic charges. Atomic dipole contributions to the neighboring atom electrostatic potentials of the fluorochloromethanes are found to be of comparable size to the atomic charge contributions and increase the accuracy of Siegbahn's model for the QTAIM charge model results</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1355683-deep-morphological-spectral-study-snr-rcw-fermi-lat','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1355683-deep-morphological-spectral-study-snr-rcw-fermi-lat"><span>Deep morphological and spectral study of the SNR RCW 86 with Fermi-<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Ajello, M.</p> <p>2016-03-02</p> <p>RCW 86 is a young supernova remnant (SNR) showing a shell-type structure at several wavelengths and is thought to be an efficient cosmic-ray (CR) accelerator. Earlier Fermi Large Area Telescope results reported the detection of γ-ray emission coincident with the position of RCW 86 but its origin (leptonic or hadronic) remained unclear due to the poor statistics. Thanks to 6.5 years of data acquired by the Fermi -<span class="hlt">LAT</span> and the new event reconstruction Pass 8, we report the significant detection of spatially extended emission coming from RCW 86. The spectrum is described by a power-law function with a very hardmore » photon index (Γ = 1.42±0.1 stat ±0.06 syst) in the 0.1–500 GeV range and an energy <span class="hlt">flux</span> above 100 MeV of (2.91 ± 0.8stat ± 0.12 syst) × 10- 11 erg cm -2 s -1. Gathering all the available multiwavelength (MWL) data, we perform a broadband modeling of the nonthermal emission of RCW 86 to constrain parameters of the nearby medium and bring new hints about the origin of the γ-ray emission. For the whole SNR, the modeling favors a leptonic scenario in the framework of a two-zone model with an average magnetic field of 10.2 ± 0.7 μG and a limit on the maximum energy injected into protons of 2 × 10 49 erg for a density of 1 cm -3. In addition, parameter values are derived for the North-East (NE) and South-West (SW) regions of RCW 86, providing the first indication of a higher magnetic field in the SW region.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1355725-fermi-lat-detection-transient-gamma-ray-flare-vicinity-binary-star-dg-cvn','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1355725-fermi-lat-detection-transient-gamma-ray-flare-vicinity-binary-star-dg-cvn"><span>Fermi/<span class="hlt">LAT</span> detection of a transient gamma-ray flare in the vicinity of the binary star DG CVn</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Loh, Alan; Corbel, Stéphane; Dubus, Guillaume</p> <p>2017-02-16</p> <p>Solar flares are regularly detected by the Large Area Telescope (<span class="hlt">LAT</span>) on board the Fermi satellite, however no γ-ray emission from other stellar eruptions has ever been captured. The Swift detection in 2014 April of a powerful outburst originating from DG CVn, with associated optical and radio emissions, enticed us to search for possible 0.1–100 GeV emission from this flaring nearby binary star using the Fermi/<span class="hlt">LAT</span>. No γ-ray emission is detected from DG CVn in 2014, but we report a significant γ-ray excess in 2012 November, at a position consistent with that of the binary. There are no reports ofmore » contemporary flaring at other wavelengths from DG CVn or any other source within the error circle of the γ-ray source. As a result, we argue that the γ-ray flare is more likely to have been associated with a background blazar than with DG CVn and identify a candidate for follow-up study.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22663870-hall-effectmediated-magnetic-flux-transport-protoplanetary-disks','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22663870-hall-effectmediated-magnetic-flux-transport-protoplanetary-disks"><span>Hall Effect–Mediated Magnetic <span class="hlt">Flux</span> Transport in Protoplanetary Disks</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Bai, Xue-Ning; Stone, James M.</p> <p>2017-02-10</p> <p>The global evolution of protoplanetary disks (PPDs) has recently been shown to be largely controlled by the amount of poloidal magnetic <span class="hlt">flux</span> threading the disk. The amount of magnetic <span class="hlt">flux</span> must also coevolve with the disk, as a result of magnetic <span class="hlt">flux</span> transport, a process that is poorly understood. In weakly ionized gas as in PPDs, magnetic <span class="hlt">flux</span> is largely frozen in the <span class="hlt">electron</span> fluid, except when resistivity is large. When the disk is largely laminar, we show that the relative drift between the <span class="hlt">electrons</span> and ions (the Hall drift), and the ions and neutral fluids (ambipolar drift) can playmore » a dominant role on the transport of magnetic <span class="hlt">flux</span>. Using two-dimensional simulations that incorporate the Hall effect and ambipolar diffusion (AD) with prescribed diffusivities, we show that when large-scale poloidal field is aligned with disk rotation, the Hall effect rapidly drags magnetic <span class="hlt">flux</span> inward at the midplane region, while it slowly pushes <span class="hlt">flux</span> outward above/below the midplane. This leads to a highly radially elongated field configuration as a global manifestation of the Hall-shear instability. This field configuration further promotes rapid outward <span class="hlt">flux</span> transport by AD at the midplane, leading to instability saturation. In quasi-steady state, magnetic <span class="hlt">flux</span> is transported outward at approximately the same rate at all heights, and the rate is comparable to the Hall-free case. For anti-aligned field polarity, the Hall effect consistently transports magnetic <span class="hlt">flux</span> outward, leading to a largely vertical field configuration in the midplane region. The field lines in the upper layer first bend radially inward and then outward to launch a disk wind. Overall, the net rate of outward <span class="hlt">flux</span> transport is about twice as fast as that of the aligned case. In addition, the rate of <span class="hlt">flux</span> transport increases with increasing disk magnetization. The absolute rate of transport is sensitive to disk microphysics, which remains to be explored in future studies.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20090020530','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20090020530"><span>First Results on the High Energy Cosmic Ray <span class="hlt">Electron</span> Spectrum from Fermi <span class="hlt">Lat</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Moiseev, Alexander</p> <p>2009-01-01</p> <p>This viewgraph presentation addresses energy reconstruction, <span class="hlt">electron</span>-hadron separation, validation of Monte Carlo with flight data and an assessment of systematic errors from the Fermi Large Area Telescope.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_23 --> <div id="page_24" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="461"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.ncbi.nlm.nih.gov/pubmed/17616111','PUBMED'); return false;" href="https://www.ncbi.nlm.nih.gov/pubmed/17616111"><span>Quantum theory of atoms in molecules charge-charge <span class="hlt">flux</span>-dipole <span class="hlt">flux</span> models for the infrared intensities of X(2)CY (X = H, F, Cl; Y = O, S) molecules.</span></a></p> <p><a target="_blank" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Faria, Sergio H D M; da Silva, João Viçozo; Haiduke, Roberto L A; Vidal, Luciano N; Vazquez, Pedro A M; Bruns, Roy E</p> <p>2007-08-16</p> <p>The molecular dipole moments, their derivatives, and the fundamental IR intensities of the X2CY (X = H, F, Cl; Y = O, S) molecules are determined from QTAIM atomic charges and dipoles and their <span class="hlt">fluxes</span> at the MP2/6-311++G(3d,3p) level. Root-mean-square errors of +/-0.03 D and +/-1.4 km mol(-1) are found for the molecular dipole moments and fundamental IR intensities calculated using quantum theory of atoms in molecules (QTAIM) parameters when compared with those obtained directly from the MP2/6-311++G(3d,3p) calculations and +/-0.05 D and 51.2 km mol(-1) when compared with the experimental values. Charge (C), charge <span class="hlt">flux</span> (CF), and dipole <span class="hlt">flux</span> (DF) contributions are reported for all the normal vibrations of these molecules. A large negative correlation coefficient of -0.83 is calculated between the charge <span class="hlt">flux</span> and dipole <span class="hlt">flux</span> contributions and indicates that <span class="hlt">electronic</span> charge transfer from one side of the molecule to the other during vibrations is accompanied by a relaxation effect with <span class="hlt">electron</span> density polarization in the opposite direction. The characteristic substituent effect that has been observed for experimental infrared intensity parameters and core <span class="hlt">electron</span> ionization energies has been applied to the CCFDF/QTAIM parameters of F2CO, Cl2CO, F2CS, and Cl2CS. The individual atomic charge, atomic charge <span class="hlt">flux</span>, and atomic dipole <span class="hlt">flux</span> contributions are seen to obey the characteristic substituent effect equation just as accurately as the total dipole moment derivative. The CH, CF, and CCl stretching normal modes of these molecules are shown to have characteristic sets of charge, charge <span class="hlt">flux</span>, and dipole <span class="hlt">flux</span> contributions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014MeScT..25j5008P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014MeScT..25j5008P"><span><span class="hlt">Flux</span>-gate magnetometer spin axis offset calibration using the <span class="hlt">electron</span> drift instrument</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Plaschke, Ferdinand; Nakamura, Rumi; Leinweber, Hannes K.; Chutter, Mark; Vaith, Hans; Baumjohann, Wolfgang; Steller, Manfred; Magnes, Werner</p> <p>2014-10-01</p> <p>Spin-stabilization of spacecraft immensely supports the in-flight calibration of on-board <span class="hlt">flux</span>-gate magnetometers (FGMs). From 12 calibration parameters in total, 8 can be easily obtained by spectral analysis. From the remaining 4, the spin axis offset is known to be particularly variable. It is usually determined by analysis of Alfvénic fluctuations that are embedded in the solar wind. In the absence of solar wind observations, the spin axis offset may be obtained by comparison of FGM and <span class="hlt">electron</span> drift instrument (EDI) measurements. The aim of our study is to develop methods that are readily usable for routine FGM spin axis offset calibration with EDI. This paper represents a major step forward in this direction. We improve an existing method to determine FGM spin axis offsets from EDI time-of-flight measurements by providing it with a comprehensive error analysis. In addition, we introduce a new, complementary method that uses EDI beam direction data instead of time-of-flight data. Using Cluster data, we show that both methods yield similarly accurate results, which are comparable yet more stable than those from a commonly used solar wind-based method.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1357511-eight-ray-pulsars-discovered-blind-frequency-searches-fermi-lat-data','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1357511-eight-ray-pulsars-discovered-blind-frequency-searches-fermi-lat-data"><span>Eight γ-Ray Pulsars Discovered In Blind Frequency Searches Of Fermi <span class="hlt">Lat</span> Data</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Saz Parkinson, P. M.; Dormody, M.; Ziegler, M.; ...</p> <p>2010-11-19</p> <p>We report the discovery of eight γ-ray pulsars in blind frequency searches of ~650 source positions using the Large Area Telescope (<span class="hlt">LAT</span>), on board the Fermi Gamma-ray Space Telescope. We present the timing models, light curves, and detailed spectral parameters of the new pulsars. PSRs J1023-5746, J1044-5737, J1413-5205, J1429-5911, and J1954+2836 are young (τ c < 100 kyr), energetic (more » $$\\dot{E} \\gtrsim 10^{36}$$ erg s–1), and located within the Galactic plane (|b| < 3°). The remaining three pulsars, PSRs J1846+0919, J1957+5033, and J2055+25, are less energetic, and located off the plane. Five pulsars are associated with sources included in the Fermi-<span class="hlt">LAT</span> bright γ-ray source list, but only one, PSR J1413–6205, is clearly associated with an EGRET source. PSR J1023–5746 has the smallest characteristic age (τ c = 4.6 kyr) and is the most energetic ($$\\dot{E} = 1.1 \\times 10^{37}$$ erg s–1) of all γ-ray pulsars discovered so far in blind searches. By analyzing >100 ks of publicly available archival Chandra X-ray data, we have identified the likely counterpart of PSR J1023–5746 as a faint, highly absorbed source, CXOU J102302.8-574606. The large X-ray absorption indicates that this could be among the most distant γ-ray pulsars detected so far. PSR J1023–5746 is positionally coincident with the TeV source HESS J1023–575, located near the young stellar cluster Westerlund 2, while PSR J1954+2836 is coincident with a 4.3σ excess reported by Milagro at a median energy of 35 TeV. PSRs J1957+5033 and J2055+25 have the largest characteristic ages (τ c ~ 1 Myr) and are the least energetic ($$\\dot{E} \\sim 5\\times 10^{33}$$ erg s–1) of the newly discovered pulsars. We used recent XMM observations to identify the counterpart of PSR J2055+25 as XMMU J205549.4+253959. Deep radio follow-up observations of the eight pulsars resulted in no detections of pulsations and upper limits comparable to the faintest known radio pulsars, indicating that these</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013AGUFMSM11B2117F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013AGUFMSM11B2117F"><span>Dynamics of Single <span class="hlt">Flux</span> Rope in the Reconnection Scaling Experiment</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Feng, Y.; Sears, J.; Intrator, T.; Weber, T.; Swan, H.; Dunn, J. P.; Gao, K.; Chapdelaine, L.</p> <p>2013-12-01</p> <p>A magnetic <span class="hlt">flux</span> tube threaded by current is a <span class="hlt">flux</span> rope with helically twisted field lines. In the Reconnection Scaling Experiment (RSX) we use a plasma gun to generate a single <span class="hlt">flux</span> rope with a choice of axial boundary conditions. If this <span class="hlt">flux</span> rope is driven hard enough, i.e., when J●B /B2 is larger than the kink instability threshold, we measure a helically distorted kinked structure. Rather than exploding in an Alfvén time, this kink appears to saturate to a steady amplitude, helical, gyrating <span class="hlt">flux</span> rope, which persists as long as the plasma gun sources the current. To understand it, we have experimentally measured three-dimensional (3D) profiles of various quantities of this <span class="hlt">flux</span> rope. These quantities include magnetic field B, plasma density n and potential φ, ion flow velocity vi, so that current density J, <span class="hlt">electron</span> flow velocity ve and <span class="hlt">electron</span> pressure Pe can also be derived. Consequently we can analyze the single <span class="hlt">flux</span> rope dynamics systematically in 3D. Besides gyrating (writhe), we also find the <span class="hlt">flux</span> rope has a spin (twist) center, around which the J×B - ▽Pe ≠ 0 suggesting that there should be other forces for the radial balance. We also find that there is a reverse current moving around with the <span class="hlt">flux</span> rope at some locations, i.e. there are local induced currents that are not at all apparent from measurements outside the 3D volume. Work supported by LANL-DOE, DOE Fusion Energy Sciences DE-AC52-06NA25396, NASA Geospace NNHIOA044I Basic, CMSO, SULI, NUF.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=19920053480&hterms=Radon&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D60%26Ntt%3DRadon','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=19920053480&hterms=Radon&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D60%26Ntt%3DRadon"><span>On the modulation of X ray <span class="hlt">fluxes</span> in thunderstorms</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Mccarthy, Michael P.; Parks, George K.</p> <p>1992-01-01</p> <p>The production of X-ray <span class="hlt">fluxes</span> in thunderstorms has been attributed to bremsstrahlung. Assuming this, another question arises. How can a thunderstorm modulate the number density of <span class="hlt">electrons</span> which are sufficiently energetic to produce X-rays? As a partial answer to this question, the effects of typical thunderstorm electric fields on a background population of energetic <span class="hlt">electrons</span>, such as produced by cosmic ray secondaries and their decays or the decay of airborne radionuclides, are considered. The observed variation of X-ray <span class="hlt">flux</span> is shown to be accounted for by a simple model involving typical electric field strengths. A necessary background <span class="hlt">electron</span> number density is found from the model and is determined to be more than 2 orders of magnitude higher than that available from radon decay and a factor of 8 higher than that available from cosmic ray secondaries. The ionization enhancement due to energetic <span class="hlt">electrons</span> and X-rays is discussed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20140009234','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20140009234"><span>Chandra X-Ray Observations of the Two Brightest Unidentified High Galactic Latitude Fermi-<span class="hlt">LAT</span> Gamma-Ray Sources</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Cheung, C. C.; Donato, D.; Gehrels, N.; Sokolovsky, K. V.; Giroletti, M.</p> <p>2012-01-01</p> <p>We present Chandra ACIS-I X-ray observations of 0FGL J1311.9-3419 and 0FGL J1653.4-0200, the two brightest high Galactic latitude (absolute value (beta) >10 deg) gamma-ray sources from the three-month Fermi Large Area Telescope (<span class="hlt">LAT</span>) bright source list that are still unidentified. Both were also detected previously by EGRET, and despite dedicated multi-wavelength follow-up, they are still not associated with established classes of gamma-ray emitters like pulsars or radio-loud active galactic nuclei. X-ray sources found in the ACIS-I fields of view are cataloged, and their basic properties are determined. These are discussed as candidate counterparts to 0FGL J1311.9-3419 and 0FGL J1653.4-0200, with particular emphasis on the brightest of the 9 and 13 Chandra sources detected within the respective Fermi-<span class="hlt">LAT</span> 95% confidence regions. Further follow-up studies, including optical photometric and spectroscopic observations, are necessary to identify these X-ray candidate counterparts in order to ultimately reveal the nature of these enigmatic gamma-ray objects.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://ntrs.nasa.gov/search.jsp?R=20040088452&hterms=splash&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dsplash','NASA-TRS'); return false;" href="https://ntrs.nasa.gov/search.jsp?R=20040088452&hterms=splash&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3Dsplash"><span>Radiation dose from reentrant <span class="hlt">electrons</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Badhwar, G. D.; Watts, J.; Cleghorn, T. E.</p> <p>2001-01-01</p> <p>In estimating the crew exposures during an extra vehicular activity (EVA), the contribution of reentrant <span class="hlt">electrons</span> has always been neglected. Although the <span class="hlt">flux</span> of these <span class="hlt">electrons</span> is small compared to the <span class="hlt">flux</span> of trapped <span class="hlt">electrons</span>, their energy spectrum extends to several GeV compared to about 7 MeV for trapped <span class="hlt">electrons</span>. This is also true of splash <span class="hlt">electrons</span>. Using the measured reentrant <span class="hlt">electron</span> energy spectra, it is shown that the dose contribution of these <span class="hlt">electrons</span> to the blood forming organs (BFO) is more that 10 times greater than that from the trapped <span class="hlt">electrons</span>. The calculations also show that the dose-depth response is a very slowly changing function of depth, and thus adding reasonable amounts of additional shielding would not significantly lower the dose to BFO. Published by Elsevier Science Ltd.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015ApJ...809..102L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015ApJ...809..102L"><span>GeV γ-ray Emission Detected by Fermi-<span class="hlt">LAT</span> Probably Associated with the Thermal Composite Supernova Remnant Kesteven 41 in a Molecular Environment</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Liu, Bing; Chen, Yang; Zhang, Xiao; Zhang, Gao-Yuan; Xing, Yi; Pannuti, Thomas G.</p> <p>2015-08-01</p> <p>Hadronic emission from supernova remnant (SNR)-molecular cloud (MC) association systems has been widely regarded as a probe of shock-accelerated cosmic-ray protons. Here, we report on the detection of a γ-ray emission source with a significance of 24σ in 0.2-300 GeV, projected to lie to the northwest of the thermal composite SNR Kesteven 41, using 5.6 years of Fermi-Large Area Telescope (<span class="hlt">LAT</span>) observation data. No significant long-term variability in the energy range 0.2-300 GeV is detected around this source. The 3σ error circle, 0.09° in radius, covers the 1720 MHz OH maser and is essentially consistent with the location of the VLSR˜ -50 km s-1 MC with which the SNR interacts. The source emission has an exponential cutoff power-law spectrum with a photon index of 1.9 ± 0.1 and a cutoff energy of 4.0+/- 0.9 GeV, and the corresponding 0.2-300 GeV luminosity is ˜ 1.3× 1036 erg s-1 at a distance of 12 kpc. There is no radio pulsar in the 3σ circle responsible for the high γ-ray luminosity. While the inverse Compton scattering scenario would lead to difficulty in the <span class="hlt">electron</span> energy budget, the source emission can naturally be explained by the hadronic interaction between the relativistic protons accelerated by the shock of SNR Kesteven 41 and the adjacent northwestern MC. In this paper, we present a list of Galactic thermal composite SNRs detected at GeV γ-ray energies by Fermi-<span class="hlt">LAT</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014ApJ...794L..16L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014ApJ...794L..16L"><span>HESS J1640-465 and HESS J1641-463: Two Intriguing TeV Sources in Light of New Fermi-<span class="hlt">LAT</span> Observations</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Lemoine-Goumard, M.; Grondin, M.-H.; Acero, F.; Ballet, J.; Laffon, H.; Reposeur, T.</p> <p>2014-10-01</p> <p>We report on γ-ray analysis of the region containing the bright TeV source HESS J1640-465 and the close-by TeV source HESS J1641-463 using 64 months of observations with the Fermi Large Area Telescope (<span class="hlt">LAT</span>). Previously only one GeV source was reported in this region and was associated with HESS J1640-465. With an increased data set and the improved sensitivity afforded by the reprocessed data (P7REP) of the <span class="hlt">LAT</span>, we now report the detection, morphological study, and spectral analysis of two distinct sources above 100 MeV. The softest emission in this region comes from the TeV source HESS J1641-463 which is well fitted with a power law of index Γ = 2.47 ± 0.05 ± 0.06 and presents no significant γ-ray signal above 10 GeV, which contrasts with its hard spectrum at TeV energies. The Fermi-<span class="hlt">LAT</span> spectrum of the second TeV source, HESS J1640-465 is well described by a power-law shape of index Γ = 1.99 ± 0.04 ± 0.07 that links up naturally with the spectral data points obtained by the High Energy Stereoscopic System (H.E.S.S.). These new results provide new constraints concerning the identification of these two puzzling γ-ray sources.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012ATel.4660....1C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012ATel.4660....1C"><span>Fermi <span class="hlt">LAT</span> detection of renewed GeV flaring activity from PKS 0426-380</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ciprini, Stefano</p> <p>2012-12-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the BL Lac object PKS 0426-380 (also known as 2FGL J0428.6-3756, Nolan et al. 2012, ApJS, 199, 31, and RX J0428.6-3756) with radio coordinates R.A.: 67.16843 deg, Dec: -37.93877 deg, J2000 (Johnston et al. 1995, AJ, 110, 880) and redshift z=1.111 (Heidt et al....</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016ATel.9008....1V','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016ATel.9008....1V"><span>Fermi/<span class="hlt">LAT</span> search for counterpart to the IceCube event 67093193 (run 127853)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Vianello, G.; Magill, J. D.; Omodei, N.; Kocevski, D.; Ajello, M.; Buson, S.; Krauss, F.; Chiang, J.</p> <p>2016-04-01</p> <p>on behalf of the Fermi-<span class="hlt">LAT</span> team: We have searched the Fermi Large Area Telescope data for a high-energy gamma-ray counterpart for the IceCube High Energy Starting Event (HESE) 67093193, detected in run 127853 on 2016-04-27 05:52:32.00 UT (AMON GCN notice rev. 2, http://gcn.gsfc.nasa.gov/notices_amon/67093193_127853.amon . See http://gcn.gsfc.nasa.gov/doc/Public_Doc_AMON_IceCube_GCN_Alerts_v2.pdf for a description of HESE events and related GCN notices).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015A%26A...574A..27H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015A%26A...574A..27H"><span>Probing the gamma-ray emission from HESS J1834-087 using H.E.S.S. and Fermi <span class="hlt">LAT</span> observations</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>H. E. S. S. Collaboration; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Angüner, E.; Anton, G.; Backes, M.; Balenderan, S.; Balzer, A.; Barnacka, A.; Becherini, Y.; Becker Tjus, J.; Bernlöhr, K.; Birsin, E.; Bissaldi, E.; Biteau, J.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Brucker, J.; Brun, F.; Brun, P.; Bulik, T.; Carrigan, S.; Casanova, S.; Chadwick, P. M.; Chalme-Calvet, R.; Chaves, R. C. G.; Cheesebrough, A.; Chrétien, M.; Colafrancesco, S.; Cologna, G.; Conrad, J.; Couturier, C.; Cui, Y.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; deWilt, P.; Dickinson, H. J.; Djannati-Ataï, A.; Domainko, W.; O'C. Drury, L.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Edwards, T.; Egberts, K.; Eger, P.; Espigat, P.; Farnier, C.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fernandez, D.; Fiasson, A.; Fontaine, G.; Förster, A.; Füßling, M.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Grondin, M.-H.; Grudzińska, M.; Häffner, S.; Hahn, J.; Harris, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Holler, M.; Horns, D.; Jacholkowska, A.; Jahn, C.; Jamrozy, M.; Janiak, M.; Jankowsky, F.; Jung, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kaufmann, S.; Khélifi, B.; Kieffer, M.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kneiske, T.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Krayzel, F.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lefaucheur, J.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; McComb, T. J. L.; Méhault, J.; Meintjes, P. J.; Menzler, U.; Meyer, M.; Moderski, R.; Mohamed, M.; Moulin, E.; Murach, T.; Naumann, C. L.; de Naurois, M.; Niemiec, J.; Nolan, S. J.; Oakes, L.; Odaka, H.; Ohm, S.; de Oña Wilhelmi, E.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perez, J.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Poon, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Raue, M.; Reichardt, I.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Rob, L.; Romoli, C.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Sanchez, D. A.; Santangelo, A.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Sol, H.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tluczykont, M.; Trichard, C.; Valerius, K.; van Eldik, C.; van Soelen, B.; Vasileiadis, G.; Venter, C.; Viana, A.; Vincent, P.; Völk, H. J.; Volpe, F.; Vorster, M.; Vuillaume, T.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; Ward, M.; Weidinger, M.; Weitzel, Q.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zacharias, M.; Zdziarski, A. A.; Zech, A.; Zechlin, H.-S.</p> <p>2015-02-01</p> <p>Aims: Previous observations with the High Energy Stereoscopic System (H.E.S.S.) have revealed an extended very-high-energy (VHE; E> 100 GeV) γ-ray source, HESS J1834-087, coincident with the supernova remnant (SNR) W41. The origin of the γ-ray emission was investigated in more detail with the H.E.S.S. array and the Large Area Telescope (<span class="hlt">LAT</span>) onboard the Fermi Gamma-ray Space Telescope. Methods: The γ-ray data provided by 61 h of observations with H.E.S.S., and four years with the Fermi <span class="hlt">LAT</span> were analyzed, covering over five decades in energy from 1.8 GeV up to 30 TeV. The morphology and spectrum of the TeV and GeV sources were studied and multiwavelength data were used to investigate the origin of the γ-ray emission toward W41. Results: The TeV source can be modeled with a sum of two components: one point-like and one significantly extended (σTeV = 0.17° ± 0.01°), both centered on SNR W41 and exhibiting spectra described by a power law with index ΓTeV ≃ 2.6. The GeV source detected with Fermi <span class="hlt">LAT</span> is extended (σGeV = 0.15° ± 0.03°) and morphologically matches the VHE emission. Its spectrum can be described by a power-law model with an index ΓGeV = 2.15 ± 0.12 and smoothly joins the spectrum of the whole TeV source. A break appears in the γ-ray spectra around 100 GeV. No pulsations were found in the GeV range. Conclusions: Two main scenarios are proposed to explain the observed emission: a pulsar wind nebula (PWN) or the interaction of SNR W41 with an associated molecular cloud. X-ray observations suggest the presence of a point-like source (a pulsar candidate) near the center of the remnant and nonthermal X-ray diffuse emission that could arise from the possibly associated PWN. The PWN scenario is supported by the compatible positions of the TeV and GeV sources with the putative pulsar. However, the spectral energy distribution from radio to γ-rays is reproduced by a one-zone leptonic model only if an excess of low-energy <span class="hlt">electrons</span> is injected</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016PhRvD..94a4014H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016PhRvD..94a4014H"><span>Charm contribution to the atmospheric neutrino <span class="hlt">flux</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Halzen, Francis; Wille, Logan</p> <p>2016-07-01</p> <p>We revisit the estimate of the charm particle contribution to the atmospheric neutrino <span class="hlt">flux</span> that is expected to dominate at high energies because long-lived high-energy pions and kaons interact in the atmosphere before decaying into neutrinos. We focus on the production of forward charm particles which carry a large fraction of the momentum of the incident proton. In the case of strange particles, such a component is familiar from the abundant production of K+Λ pairs. These forward charm particles can dominate the high-energy atmospheric neutrino <span class="hlt">flux</span> in underground experiments. Modern collider experiments have no coverage in the very large rapidity region where charm forward pair production dominates. Using archival accelerator data as well as IceCube measurements of atmospheric <span class="hlt">electron</span> and muon neutrino <span class="hlt">fluxes</span>, we obtain an upper limit on forward D¯0Λc pair production and on the associated <span class="hlt">flux</span> of high-energy atmospheric neutrinos. We conclude that the prompt <span class="hlt">flux</span> may dominate the much-studied central component and represent a significant contribution to the TeV atmospheric neutrino <span class="hlt">flux</span>. Importantly, it cannot accommodate the PeV <span class="hlt">flux</span> of high-energy cosmic neutrinos, or the excess of events observed by IceCube in the 30-200 TeV energy range indicating either structure in the <span class="hlt">flux</span> of cosmic accelerators, or a presence of more than one component in the cosmic <span class="hlt">flux</span> observed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013JETP..116...59P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013JETP..116...59P"><span>Variable gamma-ray sky at 1 GeV</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Pshirkov, M. S.; Rubtsov, G. I.</p> <p>2013-01-01</p> <p>We search for the long-term variability of the gamma-ray sky in the energy range E > 1 GeV with 168 weeks of the gamma-ray telescope Fermi-<span class="hlt">LAT</span> data. We perform a full sky blind search for regions with variable <span class="hlt">flux</span> looking for deviations from uniformity. We bin the sky into 12288 pixels using the HEALPix package and use the Kolmogorov-Smirnov test to compare weekly photon counts in each pixel with the constant <span class="hlt">flux</span> hypothesis. The weekly exposure of Fermi-<span class="hlt">LAT</span> for each pixel is calculated with the Fermi-<span class="hlt">LAT</span> tools. We consider <span class="hlt">flux</span> variations in a pixel significant if the statistical probability of uniformity is less than 4 × 10-6, which corresponds to 0.05 false detections in the whole set. We identified 117 variable sources, 27 of which have not been reported variable before. The sources with previously unidentified variability contain 25 active galactic nuclei (AGN) belonging to the blazar class (11 BL Lacs and 14 FSRQs), one AGN of an uncertain type, and one pulsar PSR J0633+1746 (Geminga).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/21562657-fermi-gamma-ray-space-telescope-observations-gamma-ray-outburst-from-november','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/21562657-fermi-gamma-ray-space-telescope-observations-gamma-ray-outburst-from-november"><span>FERMI GAMMA-RAY SPACE TELESCOPE OBSERVATIONS OF THE GAMMA-RAY OUTBURST FROM 3C454.3 IN NOVEMBER 2010</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Abdo, A. A.; Ackermann, M.; Ajello, M.</p> <p></p> <p>The flat-spectrum radio quasar 3C454.3 underwent an extraordinary 5 day {gamma}-ray outburst in 2010 November when the daily <span class="hlt">flux</span> measured with the Fermi Large Area Telescope (<span class="hlt">LAT</span>) at photon energies E > 100 MeV reached (66 {+-} 2) x 10{sup -6} photons cm{sup -2} s{sup -1}. This is a factor of three higher than its previous maximum <span class="hlt">flux</span> recorded in 2009 December and {approx}> 5 times brighter than the Vela pulsar, which is normally the brightest source in the {gamma}-ray sky. The 3 hr peak <span class="hlt">flux</span> was (85 {+-} 5)x10{sup -6} photons cm{sup -2} s{sup -1}, corresponding to an apparentmore » isotropic luminosity of (2.1 {+-} 0.2)x10{sup 50} erg s{sup -1}, the highest ever recorded for a blazar. In this Letter, we investigate the features of this exceptional event in the {gamma}-ray band of the Fermi-<span class="hlt">LAT</span>. In contrast to previous flares of the same source observed with the Fermi-<span class="hlt">LAT</span>, clear spectral changes are observed during the flare.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2011ApJ...733L..26A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2011ApJ...733L..26A"><span>Fermi Gamma-ray Space Telescope Observations of the Gamma-ray Outburst from 3C454.3 in November 2010</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Abdo, A. A.; Ackermann, M.; Ajello, M.; Allafort, A.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bellazzini, R.; Berenji, B.; Blandford, R. D.; Bloom, E. D.; Bonamente, E.; Borgland, A. W.; Bouvier, A.; Bregeon, J.; Brigida, M.; Bruel, P.; Buehler, R.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caraveo, P. A.; Casandjian, J. M.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Chekhtman, A.; Cheung, C. C.; Chiang, J.; Ciprini, S.; Claus, R.; Conrad, J.; Cutini, S.; D'Ammando, F.; de Angelis, A.; de Palma, F.; Dermer, C. D.; Digel, S. W.; Silva, E. do Couto e.; Drell, P. S.; Dubois, R.; Dumora, D.; Escande, L.; Favuzzi, C.; Fegan, S. J.; Ferrara, E. C.; Fortin, P.; Fukazawa, Y.; Fusco, P.; Gargano, F.; Gasparrini, D.; Gehrels, N.; Germani, S.; Giglietto, N.; Giommi, P.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Grenier, I. A.; Grove, J. E.; Guiriec, S.; Hadasch, D.; Hayashida, M.; Hays, E.; Horan, D.; Itoh, R.; Jóhannesson, G.; Johnson, A. S.; Kamae, T.; Katagiri, H.; Kataoka, J.; Knödlseder, J.; Kuss, M.; Lande, J.; Larsson, S.; Latronico, L.; Lee, S.-H.; Longo, F.; Loparco, F.; Lott, B.; Lovellette, M. N.; Lubrano, P.; Madejski, G. M.; Makeev, A.; Mazziotta, M. N.; McConville, W.; McEnery, J. E.; Michelson, P. F.; Mitthumsiri, W.; Mizuno, T.; Moiseev, A. A.; Monte, C.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Naumann-Godo, M.; Nishino, S.; Nolan, P. L.; Norris, J. P.; Nuss, E.; Ohsugi, T.; Okumura, A.; Orlando, E.; Ormes, J. F.; Paneque, D.; Pelassa, V.; Pesce-Rollins, M.; Pierbattista, M.; Piron, F.; Porter, T. A.; Rainò, S.; Rando, R.; Razzaque, S.; Reimer, A.; Reimer, O.; Ritz, S.; Roth, M.; Sadrozinski, H. F.-W.; Sanchez, D.; Scargle, J. D.; Schalk, T. L.; Sgrò, C.; Siskind, E. J.; Smith, P. D.; Spandre, G.; Spinelli, P.; Strickman, M. S.; Takahashi, H.; Takahashi, T.; Tanaka, T.; Tanaka, Y.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Tibaldo, L.; Torres, D. F.; Tosti, G.; Tramacere, A.; Troja, E.; Vandenbroucke, J.; Vasileiou, V.; Vianello, G.; Vilchez, N.; Vitale, V.; Waite, A. P.; Wang, P.; Winer, B. L.; Wood, K. S.; Yang, Z.; Ziegler, M.</p> <p>2011-06-01</p> <p>The flat-spectrum radio quasar 3C454.3 underwent an extraordinary 5 day γ-ray outburst in 2010 November when the daily <span class="hlt">flux</span> measured with the Fermi Large Area Telescope (<span class="hlt">LAT</span>) at photon energies E > 100 MeV reached (66 ± 2) × 10-6 photons cm-2 s-1. This is a factor of three higher than its previous maximum <span class="hlt">flux</span> recorded in 2009 December and >~ 5 times brighter than the Vela pulsar, which is normally the brightest source in the γ-ray sky. The 3 hr peak <span class="hlt">flux</span> was (85 ± 5)×10-6 photons cm-2 s-1, corresponding to an apparent isotropic luminosity of (2.1 ± 0.2)×1050 erg s-1, the highest ever recorded for a blazar. In this Letter, we investigate the features of this exceptional event in the γ-ray band of the Fermi-<span class="hlt">LAT</span>. In contrast to previous flares of the same source observed with the Fermi-<span class="hlt">LAT</span>, clear spectral changes are observed during the flare.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012ATel.4409....1O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012ATel.4409....1O"><span>Fermi <span class="hlt">LAT</span> detection of a continuing increase of gamma-ray activity of CTA 102</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Orienti, M.; D'Ammando, F.</p> <p>2012-09-01</p> <p>The Large Area Telescope (<span class="hlt">LAT</span>), on board the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar CTA 102 (also known as 2FGL J2232.4+1143, Nolan et al. 2012, ApJS, 199, 31) with radio coordinates R.A.: 338.1517038 deg, Dec: 11.7308067 deg (J2000, Johnston et al. 1995, AJ, 110, 880) at redshift z=1.037 (Schmidt 1965, ApJ, 141, 1295).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1356526-contemporaneous-observations-radio-galaxy-ngc-from-radio-very-high-energy-rays','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1356526-contemporaneous-observations-radio-galaxy-ngc-from-radio-very-high-energy-rays"><span>Contemporaneous observations of the radio galaxy NGC 1275 from radio to very high energy γ -rays</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Aleksić, J.; Ansoldi, S.; Antonelli, L. A.; ...</p> <p>2014-03-27</p> <p>The radio galaxy NGC 1275, recently identified as a very high energy (VHE, >100 GeV) γ-ray emitter by MAGIC, is one of the few non-blazar active galactic nuclei detected in the VHE regime. The purpose of this work is to better understand the origin of the γ-ray emission and locate it within the galaxy. We studied contemporaneous multifrequency observations of NGC 1275 and modeled the overall spectral energy distribution. We analyzed unpublished MAGIC observations carried out between October 2009 and February 2010, and the previously published observations taken between August 2010 and February 2011. Here, we studied the multiband variabilitymore » and correlations by analyzing data of Fermi-<span class="hlt">LAT</span> in the 100 MeV–100 GeV energy band, as well as Chandra (X-ray), KVA (optical), and MOJAVE (radio) data taken during the same period. Using customized Monte Carlo simulations corresponding to early MAGIC stereoscopic data, we detect NGC 1275 also in the earlier MAGIC campaign. The <span class="hlt">flux</span> level and energy spectra are similar to the results of the second campaign. The monthly light curve above 100 GeV shows a hint of variability at the 3.6σ level. In the Fermi-<span class="hlt">LAT</span> band, both <span class="hlt">flux</span> and spectral shape variabilities are reported. Furthermore, the optical light curve is also variable and shows a clear correlation with the γ-ray <span class="hlt">flux</span> above 100 MeV. In radio, three compact components are resolved in the innermost part of the jet. One of these components shows a similar trend as the Fermi-<span class="hlt">LAT</span> and KVA light curves. The γ-ray spectra measured simultaneously with MAGIC and Fermi-<span class="hlt">LAT</span> from 100 MeV to 650 GeV can be well fitted either by a log-parabola or by a power-law with a subexponential cutoff for the two observation campaigns. A single-zone synchrotron-self-Compton model, with an <span class="hlt">electron</span> spectrum following a power-law with an exponential cutoff, can explain the broadband spectral energy distribution and the multifrequency behavior of the source. But, this model suggests an</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19740007949','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19740007949"><span>Radiation environment for ATS-F. [including ambient trapped particle <span class="hlt">fluxes</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Stassinopoulos, E. G.</p> <p>1974-01-01</p> <p>The ambient trapped particle <span class="hlt">fluxes</span> incident on the ATS-F satellite were determined. Several synchronous circular flight paths were evaluated and the effect of parking longitude on vehicle encountered intensities was investigated. Temporal variations in the <span class="hlt">electron</span> environment were considered and partially accounted for. Magnetic field calculations were performed with a current field model extrapolated to a later epoch with linear time terms. Orbital <span class="hlt">flux</span> integrations were performed with the latest proton and <span class="hlt">electron</span> environment models using new improved computational methods. The results are presented in graphical and tabular form; they are analyzed, explained, and discussed. Estimates of energetic solar proton <span class="hlt">fluxes</span> are given for a one year mission at selected integral energies ranging from 10 to 100 Mev, calculated for a year of maximum solar activity during the next solar cycle.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017ATel10109....1L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017ATel10109....1L"><span>Enhanced high-energy gamma-ray emission from the microquasar Cygnus X-3 detected by Fermi/<span class="hlt">LAT</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Loh, Alan; Corbel, Stephane</p> <p>2017-02-01</p> <p>Following the recent decrease of the hard X-ray emission from the high-mass X-ray binary Cygnus X-3 as seen by the Swift/Burst Alert Telescope (https://swift.gsfc.nasa.gov/results/transients/CygX-3/), the Large Area Telescope (<span class="hlt">LAT</span>), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed significant gamma-ray emission originating from the microquasar.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_24 --> <div id="page_25" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="481"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2010APS..DPPTP9069B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2010APS..DPPTP9069B"><span>Measurements of plasma sheath heat <span class="hlt">flux</span> in the Alcator C-Mod divertor</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Brunner, Dan; Labombard, Brian; Terry, Jim; Reinke, Matt</p> <p>2010-11-01</p> <p>Heat <span class="hlt">flux</span> is one of the most important parameters controlling the lifetime of first-wall components in fusion experiments and reactors. The sheath heat <span class="hlt">flux</span> coefficient (γ) is a parameter relating heat <span class="hlt">flux</span> (from a plasma to a material surface) to the <span class="hlt">electron</span> temperature and ion saturation current. Being such a simple expression for a kinetic process, it is of great interest to plasma edge fluid modelers. Under the assumptions of equal ion and <span class="hlt">electron</span> temperatures, no secondary <span class="hlt">electron</span> emission, and no net current to the surface the value of γ is approximately 7 [1]. Alcator C-Mod provides a unique opportunity among today's experiments to measure reactor-relevant heat <span class="hlt">fluxes</span> (100's of MW/m^2 parallel to the magnetic field) in reactor-like divertor geometry. Motivated by the DoE 2010 joint milestone to measure heat <span class="hlt">flux</span> footprints, the lower outer divertor of Alcator has been instrumented with a suite of Langmuir probes, novel surface thermocouples, and calorimeters in tiles purposefully ramped to eliminate shadowing; all within view of an IR camera. Initial results indicate that the experimentally inferred values of γ are found to agree with simple theory in the sheath limited regime and diverges to lower values as the density increases.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/servlets/purl/1179571','SCIGOV-STC'); return false;" href="https://www.osti.gov/servlets/purl/1179571"><span>Extending the Fermi-<span class="hlt">LAT</span> data processing pipeline to the grid</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Zimmer, S.; Arrabito, L.; Glanzman, T.</p> <p>2015-05-12</p> <p>The Data Handling Pipeline ("Pipeline") has been developed for the Fermi Gamma-Ray Space Telescope (Fermi) Large Area Telescope (<span class="hlt">LAT</span>) which launched in June 2008. Since then it has been in use to completely automate the production of data quality monitoring quantities, reconstruction and routine analysis of all data received from the satellite and to deliver science products to the collaboration and the Fermi Science Support Center. Aside from the reconstruction of raw data from the satellite (Level 1), data reprocessing and various event-level analyses are also reasonably heavy loads on the pipeline and computing resources. These other loads, unlike Levelmore » 1, can run continuously for weeks or months at a time. Additionally, it receives heavy use in performing production Monte Carlo tasks.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JInst..12C2045T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JInst..12C2045T"><span>Characterisation of Redlen high-<span class="hlt">flux</span> CdZnTe</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Thomas, B.; Veale, M. C.; Wilson, M. D.; Seller, P.; Schneider, A.; Iniewski, K.</p> <p>2017-12-01</p> <p>CdZnTe is a promising material for the current generation of free <span class="hlt">electron</span> laser light sources and future laser-driven γ-ray sources which require detectors capable of high <span class="hlt">flux</span> imaging at X-ray and γ-ray energies (> 10 keV) . However, at high <span class="hlt">fluxes</span> CdZnTe has been shown to polarise due to hole trapping, leading to poor performance. Novel Redlen CdZnTe material with improved hole transport properties has been designed for high <span class="hlt">flux</span> applications. Small pixel CdZnTe detectors were fabricated by Redlen Technologies and flip-chip bonded to PIXIE ASICs. An XIA Digital Gamma Finder PIXIE-16 system was used to digitise each of the nine analogue signals with a timing resolution of 10 ns. Pulse shape analysis was used to extract the rise times and amplitude of signals. These were measured as a function of applied bias voltage and used to calculate the mobility (μ) and mobility-lifetime (μτ) of <span class="hlt">electrons</span> and holes in the material for three identical detectors. The measured values of the transport properties of <span class="hlt">electrons</span> in the high-<span class="hlt">flux</span>-capable material was lower than previously reported for Redlen CdZnTe material (μeτe ~ 1 × 10-3 cm2V-1 and μe ~ 1000 cm2V-1s-1) while the hole transport properties were found to have improved (μhτh ~ 3 × 10-4 cm2V-1 and μh ~ 100 cm2V-1s-1).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/21513045-fermi-lat-observations-cosmic-ray-electrons-from-gev-tev','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/21513045-fermi-lat-observations-cosmic-ray-electrons-from-gev-tev"><span>Fermi <span class="hlt">LAT</span> observations of cosmic-ray <span class="hlt">electrons</span> from 7 GeV to 1 TeV</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Ackermann, M.; Ajello, M.; Bechtol, K.</p> <p></p> <p>We present the results of our analysis of cosmic-ray <span class="hlt">electrons</span> using about 8x10{sup 6} <span class="hlt">electron</span> candidates detected in the first 12 months on-orbit by the Fermi Large Area Telescope. This work extends our previously published cosmic-ray <span class="hlt">electron</span> spectrum down to 7 GeV, giving a spectral range of approximately 2.5 decades up to 1 TeV. We describe in detail the analysis and its validation using beam-test and on-orbit data. In addition, we describe the spectrum measured via a subset of events selected for the best energy resolution as a cross-check on the measurement using the full event sample. Our <span class="hlt">electron</span> spectrummore » can be described with a power law {proportional_to}E{sup -3.08{+-}0.05} with no prominent spectral features within systematic uncertainties. Within the limits of our uncertainties, we can accommodate a slight spectral hardening at around 100 GeV and a slight softening above 500 GeV.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19720021632','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19720021632"><span>Analysis of auroral particle <span class="hlt">fluxes</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Chappell, C. R.</p> <p>1972-01-01</p> <p>The physical processes which describe the interaction of auroral <span class="hlt">electrons</span> with the atmosphere appear to be more complex than just the Coulomb scattering of the incident primary <span class="hlt">electrons</span> with a subsequent loss of energy. The comparison of the measured backscattered <span class="hlt">electron</span> spectra with spectra predicted using a theoretical scattering calculation has led to a discrepancy for energies below about 1 to 2 keV. It was found that the very high ratio (100%) of backscattered to incident <span class="hlt">fluxes</span> for these energies could be most reasonably explained by a parallel downward-directed electric field which prevents these lower energy <span class="hlt">electrons</span> from entering the atmospheric scattering region. This parallel field with potential drop of about 1 keV is thought to have its origin in waveparticle interactions in the turbulent auroral ionosphere.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2001PhDT.........1O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2001PhDT.........1O"><span>Empirical analysis of storm-time energetic <span class="hlt">electron</span> enhancements</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>O'Brien, Thomas Paul, III</p> <p></p> <p>This Ph.D. thesis documents a program for studying the appearance of energetic <span class="hlt">electrons</span> in the Earth's outer radiation belts that is associated with many geomagnetic storms. The dynamic evolution of the <span class="hlt">electron</span> radiation belts is an outstanding empirical problem in both theoretical space physics and its applied sibling, space weather. The project emphasizes the development of empirical tools and their use in testing several theoretical models of the energization of the <span class="hlt">electron</span> belts. First, I develop the Statistical Asynchronous Regression technique to provide proxy <span class="hlt">electron</span> <span class="hlt">fluxes</span> throughout the parts of the radiation belts explored by geosynchronous and GPS spacecraft. Next, I show that a theoretical adiabatic model can relate the local time asymmetry of the proxy geosynchronous <span class="hlt">fluxes</span> to the asymmetry of the geomagnetic field. Then, I perform a superposed epoch analysis on the proxy <span class="hlt">fluxes</span> at local noon to identify magnetospheric and interplanetary precursors of relativistic <span class="hlt">electron</span> enhancements. Finally, I use statistical and neural network phase space analyses to determine the hourly evolution of <span class="hlt">flux</span> at a virtual stationary monitor. The dynamic equation quantitatively identifies the importance of different drivers of the <span class="hlt">electron</span> belts. This project provides empirical constraints on theoretical models of <span class="hlt">electron</span> acceleration.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2017JGRA..122.2900O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2017JGRA..122.2900O"><span>Energetic <span class="hlt">electron</span> precipitation in weak to moderate corotating interaction region-driven storms</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ødegaard, Linn-Kristine Glesnes; Tyssøy, Hilde Nesse; Søraas, Finn; Stadsnes, Johan; Sandanger, Marit Irene</p> <p>2017-03-01</p> <p>High-energy <span class="hlt">electron</span> precipitation from the radiation belts can penetrate deep into the mesosphere and increase the production rate of NOx and HOx, which in turn will reduce ozone in catalytic processes. The mechanisms for acceleration and loss of <span class="hlt">electrons</span> in the radiation belts are not fully understood, and most of the measurements of the precipitating <span class="hlt">flux</span> into the atmosphere have been insufficient for estimating the loss cone <span class="hlt">flux</span>. In the present study the <span class="hlt">electron</span> <span class="hlt">flux</span> measured by the NOAA POES Medium Energy Proton and <span class="hlt">Electron</span> Detectors 0° and 90° detectors is combined together with theory of pitch angle diffusion by wave-particle interaction to quantify the <span class="hlt">electron</span> <span class="hlt">flux</span> lost below 120 km altitude. Using this method, 41 weak and moderate geomagnetic storms caused by corotating interaction regions during 2006-2010 are studied. The dependence of the energetic <span class="hlt">electron</span> precipitation <span class="hlt">fluxes</span> upon solar wind parameters and geomagnetic indices is investigated. Nine storms give increased precipitation of >˜750 keV <span class="hlt">electrons</span>. Nineteen storms increase the precipitation of >˜300 keV <span class="hlt">electrons</span>, but not the >˜750 keV population. Thirteen storms either do not change or deplete the <span class="hlt">fluxes</span> at those energies. Storms that have an increase in the <span class="hlt">flux</span> of <span class="hlt">electrons</span> with energy >˜300 keV are characterized by an elevated solar wind velocity for a longer period compared to the storms that do not. Storms with increased precipitation of >˜750 keV <span class="hlt">flux</span> are distinguished by higher-energy input from the solar wind quantified by the ɛ parameter and corresponding higher geomagnetic activity.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2003AGUFMSM51E..05G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2003AGUFMSM51E..05G"><span>Examining Relativistic <span class="hlt">Electron</span> Loss in the Outer Radiation Belt</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Green, J. C.; Onsager, T. G.; O'Brien, P.</p> <p>2003-12-01</p> <p>Since the discovery of earth's radiation belts researchers have sought to identify the mechanisms that dictate the seemingly erratic relativistic <span class="hlt">electron</span> <span class="hlt">flux</span> levels in the outer belt. Contrary to intuition, relativistic <span class="hlt">electron</span> <span class="hlt">flux</span> levels do not always increase during geomagnetic storms even though these storms signify enhanced energy input from the solar wind to the magnetosphere [Reeves et al., 2003; O'Brien et al., 2001]. The fickle response of the radiation belt <span class="hlt">electrons</span> to geomagnetic activity suggests that <span class="hlt">flux</span> levels are determined by the outcome of a continuous competition between acceleration and loss. Some progress has been made developing and testing acceleration mechanisms but little is known about how relativistic <span class="hlt">electrons</span> are lost. We examine relativistic <span class="hlt">electron</span> losses in the outer belt focusing our attention on <span class="hlt">flux</span> decrease events of the type first described by Onsager et al. [2002]. The study showed a sudden decrease of geosynchronous >2MeV <span class="hlt">electron</span> <span class="hlt">flux</span> occurring simultaneously with local stretching of the magnetic field. The decrease was first observed near 15:00 MLT and progressed to all local times after a period of ˜10 hours. Expanding on the work of Onsager et al. [2002], we have identified ˜ 51 such <span class="hlt">flux</span> decrease events in the GOES and LANL data and present the results of a superposed epoch analysis of solar wind data, geomagnetic activity indicators, and locally measured magnetic field and plasma data. The analysis shows that <span class="hlt">flux</span> decreases occur after 1-2 days of quiet condition. They begin when either the solar wind dynamic pressure increases or Bz turns southward pushing hot dense plasma earthward to form a partial ring current and stretched magnetic field at dusk. Adiabatic <span class="hlt">electron</span> motion in response to the stretched magnetic field may explain the initial <span class="hlt">flux</span> reduction; however, often the <span class="hlt">flux</span> does not recover with the magnetic field recovery, indicating that true loss from the magnetosphere is occurring. Using Polar and</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016JPhCS.773a2089H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016JPhCS.773a2089H"><span>A miniaturized human-motion energy harvester using <span class="hlt">flux</span>-guided magnet stacks</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Halim, M. A.; Park, J. Y.</p> <p>2016-11-01</p> <p>We present a miniaturized electromagnetic energy harvester (EMEH) using two <span class="hlt">flux</span>-guided magnet stacks to harvest energy from human-generated vibration such as handshaking. Each <span class="hlt">flux</span>-guided magnet stack increases (40%) the magnetic <span class="hlt">flux</span> density by guiding the <span class="hlt">flux</span> lines through a soft magnetic material. The EMEH has been designed to up-convert the applied human-motion vibration to a high-frequency oscillation by mechanical impact of a spring-less structure. The high-frequency oscillator consists of the analyzed 2-magnet stack and a customized helical compression spring. A standard AAA battery sized prototype (3.9 cm3) can generate maximum 203 μW average power from human hand-shaking vibration. It has a maximum average power density of 52 μWcm-3 which is significantly higher than the current state-of-the-art devices. A 6-stage multiplier and rectifier circuit interfaces the harvester with a wearable <span class="hlt">electronic</span> load (wrist watch) to demonstrate its capability of powering small- scale <span class="hlt">electronic</span> systems from human-generated vibration.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20120013334','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20120013334"><span>Fermi-<span class="hlt">LAT</span> Constraints on the Pulsar Wind Nebula Nature of HESS J1857+026</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Rousseau, R.; Grondin, M.-H.; VanEtten, A.; Lemoine-Goumard, M.; Bogdanov, S.; Hessels, J. W. T.; Kaspi, V. M.; Arzoumanian, Z.; Camilo, F.; Casandjian, J. M.; <a style="text-decoration: none; " href="javascript:void(0); " onClick="displayelement('author_20120013334'); toggleEditAbsImage('author_20120013334_show'); toggleEditAbsImage('author_20120013334_hide'); "> <img style="display:inline; width:12px; height:12px; " src="images/arrow-up.gif" width="12" height="12" border="0" alt="hide" id="author_20120013334_show"> <img style="width:12px; height:12px; display:none; " src="images/arrow-down.gif" width="12" height="12" border="0" alt="hide" id="author_20120013334_hide"></p> <p>2012-01-01</p> <p>Since its launch, the Fermi satellite has firmly identified 5 pulsar wind nebulae plus a large number of candidates, all powered by young and energetic pulsars. HESS J1857+026 is a spatially extended gamma-ray source detected by H.E.S.S. and classified as a possible pulsar wind nebula candidate powered by PSR J1856+0245. Aims. We search for -ray pulsations from PSR J1856+0245 and explore the characteristics of its associated pulsar wind nebula. Methods. Using a rotational ephemeris obtained from the Lovell telescope at Jodrell Bank Observatory at 1.5 GHz, we phase.fold 36 months of gamma-ray data acquired by the Large Area Telescope (<span class="hlt">LAT</span>) aboard Fermi. We also perform a complete gamma-ray spectral and morphological analysis. Results. No pulsation was detected from PSR J1856+0245. However, significant emission is detected at a position coincident with the TeV source HESS J1857+026. The gamma-ray spectrum is well described by a simple power law with a spectral index of Gamma = 1.53 +/- 0.11(sub stat) +/- 0.55(sub syst) and an energy <span class="hlt">flux</span> of G(0.1 C100 GeV) = (2.71 +/- 0.52(sub stat) +/- 1.51(sub syst) X 10(exp -11) ergs/ sq cm/s. This implies a gamma.ray efficiency of approx 5 %, assuming a distance of 9 kpc, the gamma-ray luminosity of L(sub gamma) (sub PWN) (0.1 C100 GeV) = (2.5 +/- 0.5(sub stat) +/- 1.5(sub syst)) X 10(exp 35)(d/(9kpc))(exp 2) ergs/s and E-dot = 4.6 X 10(exp 36) erg /s, in the range expected for pulsar wind nebulae. Detailed multi-wavelength modeling provides new constraints on its pulsar wind nebula nature.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012A%26A...544A...3R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012A%26A...544A...3R"><span>Fermi-<span class="hlt">LAT</span> constraints on the pulsar wind nebula nature of HESS J1857+026</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Rousseau, R.; Grondin, M.-H.; Van Etten, A.; Lemoine-Goumard, M.; Bogdanov, S.; Hessels, J. W. T.; Kaspi, V. M.; Arzoumanian, Z.; Camilo, F.; Casandjian, J. M.; Espinoza, C. M.; Johnston, S.; Lyne, A. G.; Smith, D. A.; Stappers, B. W.; Caliandro, G. A.</p> <p>2012-08-01</p> <p>Context. Since its launch, the Fermi satellite has firmly identified 5 pulsar wind nebulae plus a large number of candidates, all powered by young and energetic pulsars. HESS J1857 + 026 is a spatially extended γ-ray source detected by H.E.S.S. and classified as a possible pulsar wind nebula candidate powered by PSR J1856 + 0245. Aims: We search for γ-ray pulsations from PSR J1856+0245 and explore the characteristics of its associated pulsar wind nebula. Methods: Using a rotational ephemeris obtained from the Lovell telescope at Jodrell Bank Observatory at 1.5 GHz, we phase-fold 36 months of γ-ray data acquired by the Large Area Telescope (<span class="hlt">LAT</span>) aboard Fermi. We also perform a complete γ-ray spectral and morphological analysis. Results: No γ-ray pulsations were detected from PSR J1856+0245. However, significant emission is detected at a position coincident with the TeV source HESS J1857 + 026. The γ-ray spectrum is well described by a simple power-law with a spectral index of Γ = 1.53 ± 0.11stat ± 0.55syst and an energy <span class="hlt">flux</span> of G(0.1-100 GeV) = (2.71 ± 0.52stat ± 1.51syst) × 10-11 erg cm-2 s-1. The γ-ray luminosity is LPWNγ (0.1-100 GeV)=(2.5 ± 0.5stat ± 1.5syst) × 1035 (d/9 kpc)2 erg s-1, assuming a distance of 9 kpc. This implies a γ-ray efficiency of ~5% for Ė = 4.6 × 1036 erg s-1, in the range expected for pulsar wind nebulae. Detailed multi-wavelength modeling provides new constraints on its pulsar wind nebula nature.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1356692-fermi-lat-constraints-pulsar-wind-nebula-nature-hess-j1857+026','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1356692-fermi-lat-constraints-pulsar-wind-nebula-nature-hess-j1857+026"><span>Fermi -<span class="hlt">LAT</span> constraints on the pulsar wind nebula nature of HESS J1857+026</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Rousseau, R.; Grondin, M. -H.; Van Etten, A.; ...</p> <p>2012-07-17</p> <p>Since its launch, the Fermi satellite has firmly identified 5 pulsar wind nebulae plus a large number of candidates, all powered by young and energetic pulsars. HESS J1857 + 026 is a spatially extended γ-ray source detected by H.E.S.S. and classified as a possible pulsar wind nebula candidate powered by PSR J1856 + 0245. Here, we search for γ-ray pulsations from PSR J1856+0245 and explore the characteristics of its associated pulsar wind nebula. Using a rotational ephemeris obtained from the Lovell telescope at Jodrell Bank Observatory at 1.5 GHz, we phase-fold 36 months of γ-ray data acquired by the Large Area Telescope (<span class="hlt">LAT</span>) aboard Fermi. We also perform a complete γ-ray spectral and morphological analysis. No γ-ray pulsations were detected from PSR J1856+0245. But, significant emission is detected at a position coincident with the TeV source HESS J1857 + 026. The γ-ray spectrum is well described by a simple power-law with a spectral index of Γ = 1.53 ± 0.11 stat ± 0.55 syst and an energy <span class="hlt">flux</span> of G(0.1–100 GeV) = (2.71 ± 0.52 stat ± 1.51 syst) × 10 -11 erg cm -2 s -1. The γ-ray luminosity is L PWN γ (0.1–100 GeV)=(2.5 ± 0.5 stat ± 1.5 syst) × 10 35 (d/9 kpc) 2 erg s -1, assuming a distance of 9 kpc. This implies a γ-ray efficiency of ~5% formore » $$\\dot{E}$$ = 4.6 × 10 36 erg s -1, in the range expected for pulsar wind nebulae. This detailed multi-wavelength modeling provides new constraints on its pulsar wind nebula nature.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/22660895-electron-acceleration-pulsar-wind-termination-shocks-application-crab-nebula-gamma-ray-flares','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/22660895-electron-acceleration-pulsar-wind-termination-shocks-application-crab-nebula-gamma-ray-flares"><span><span class="hlt">ELECTRON</span> ACCELERATION IN PULSAR-WIND TERMINATION SHOCKS: AN APPLICATION TO THE CRAB NEBULA GAMMA-RAY FLARES</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Kroon, John J.; Becker, Peter A.; Dermer, Charles D.</p> <p></p> <p>The γ -ray flares from the Crab Nebula observed by AGILE and Fermi -<span class="hlt">LAT</span> reaching GeV energies and lasting several days challenge the standard models for particle acceleration in pulsar-wind nebulae because the radiating <span class="hlt">electrons</span> have energies exceeding the classical radiation-reaction limit for synchrotron. Previous modeling has suggested that the synchrotron limit can be exceeded if the <span class="hlt">electrons</span> experience electrostatic acceleration, but the resulting spectra do not agree very well with the data. As a result, there are still some important unanswered questions about the detailed particle acceleration and emission processes occurring during the flares. We revisit the problem usingmore » a new analytical approach based on an <span class="hlt">electron</span> transport equation that includes terms describing electrostatic acceleration, stochastic wave-particle acceleration, shock acceleration, synchrotron losses, and particle escape. An exact solution is obtained for the <span class="hlt">electron</span> distribution, which is used to compute the associated γ -ray synchrotron spectrum. We find that in our model the γ -ray flares are mainly powered by electrostatic acceleration, but the contributions from stochastic and shock acceleration play an important role in producing the observed spectral shapes. Our model can reproduce the spectra of all the Fermi -<span class="hlt">LAT</span> and AGILE flares from the Crab Nebula, using magnetic field strengths in agreement with the multi-wavelength observational constraints. We also compute the spectrum and duration of the synchrotron afterglow created by the accelerated <span class="hlt">electrons</span>, after they escape into the region on the downstream side of the pulsar-wind termination shock. The afterglow is expected to fade over a maximum period of about three weeks after the γ -ray flare.« less</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3415458','PMC'); return false;" href="https://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3415458"><span>HSV-1 Genome Subnuclear Positioning and Associations with Host-Cell PML-NBs and Centromeres Regulate <span class="hlt">LAT</span> Locus Transcription during Latency in Neurons</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Catez, Frédéric; Picard, Christel; Held, Kathrin; Gross, Sylvain; Rousseau, Antoine; Theil, Diethilde; Sawtell, Nancy; Labetoulle, Marc; Lomonte, Patrick</p> <p>2012-01-01</p> <p>Major human pathologies are caused by nuclear replicative viruses establishing life-long latent infection in their host. During latency the genomes of these viruses are intimately interacting with the cell nucleus environment. A hallmark of herpes simplex virus type 1 (HSV-1) latency establishment is the shutdown of lytic genes expression and the concomitant induction of the latency associated (<span class="hlt">LAT</span>) transcripts. Although the setting up and the maintenance of the latent genetic program is most likely dependent on a subtle interplay between viral and nuclear factors, this remains uninvestigated. Combining the use of in situ fluorescent-based approaches and high-resolution microscopic analysis, we show that HSV-1 genomes adopt specific nuclear patterns in sensory neurons of latently infected mice (28 days post-inoculation, d.p.i.). Latent HSV-1 genomes display two major patterns, called “Single” and “Multiple”, which associate with centromeres, and with promyelocytic leukemia nuclear bodies (PML-NBs) as viral DNA-containing PML-NBs (DCP-NBs). 3D-image reconstruction of DCP-NBs shows that PML forms a shell around viral genomes and associated Daxx and ATRX, two PML partners within PML-NBs. During latency establishment (6 d.p.i.), infected mouse TGs display, at the level of the whole TG and in individual cells, a substantial increase of PML amount consistent with the interferon-mediated antiviral role of PML. “Single” and “Multiple” patterns are reminiscent of low and high-viral genome copy-containing neurons. We show that <span class="hlt">LAT</span> expression is significantly favored within the “Multiple” pattern, which underlines a heterogeneity of <span class="hlt">LAT</span> expression dependent on the viral genome copy number, pattern acquisition, and association with nuclear domains. Infection of PML-knockout mice demonstrates that PML/PML-NBs are involved in virus nuclear pattern acquisition, and negatively regulate the expression of the <span class="hlt">LAT</span>. This study demonstrates that nuclear domains</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/pages/biblio/1355168-probing-gamma-ray-emission-from-hess-j1834087-using-fermilat-observations','SCIGOV-DOEP'); return false;" href="https://www.osti.gov/pages/biblio/1355168-probing-gamma-ray-emission-from-hess-j1834087-using-fermilat-observations"><span>Probing the gamma-ray emission from HESS J1834–087 using H.E.S.S. and Fermi<span class="hlt">LAT</span> observations</span></a></p> <p><a target="_blank" href="http://www.osti.gov/pages">DOE PAGES</a></p> <p>Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; ...</p> <p>2015-01-20</p> <p>Aims. Previous observations with the High Energy Stereoscopic System (H.E.S.S.) have revealed an extended very-high-energy (VHE; E> 100 GeV) γ-ray source, HESS J1834-087, coincident with the supernova remnant (SNR) W41. The origin of the γ-ray emission was investigated in more detail with the H.E.S.S. array and the Large Area Telescope (<span class="hlt">LAT</span>) onboard the Fermi Gamma-ray Space Telescope. Methods. For this research, the γ-ray data provided by 61 h of observations with H.E.S.S., and four years with the Fermi <span class="hlt">LAT</span> were analyzed, covering over five decades in energy from 1.8 GeV up to 30 TeV. The morphology and spectrum of themore » TeV and GeV sources were studied and multiwavelength data were used to investigate the origin of the γ-ray emission toward W41. Results. The TeV source can be modeled with a sum of two components: one point-like and one significantly extended (σ TeV = 0.17° ± 0.01°), both centered on SNR W41 and exhibiting spectra described by a power law with index Γ TeV ≃ 2.6. The GeV source detected with Fermi <span class="hlt">LAT</span> is extended (σ GeV = 0.15° ± 0.03°) and morphologically matches the VHE emission. Its spectrum can be described by a power-law model with an index Γ GeV = 2.15 ± 0.12 and smoothly joins the spectrum of the whole TeV source. A break appears in the γ-ray spectra around 100 GeV. No pulsations were found in the GeV range. Conclusions. Two main scenarios are proposed to explain the observed emission: a pulsar wind nebula (PWN) or the interaction of SNR W41 with an associated molecular cloud. X-ray observations suggest the presence of a point-like source (a pulsar candidate) near the center of the remnant and nonthermal X-ray diffuse emission that could arise from the possibly associated PWN. The PWN scenario is supported by the compatible positions of the TeV and GeV sources with the putative pulsar. However, the spectral energy distribution from radio to γ-rays is reproduced by a one-zone leptonic model only if an excess of low</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20110015879','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20110015879"><span>Evaluation of the Monotonic Lagrangian Grid and <span class="hlt">Lat</span>-Long Grid for Air Traffic Management</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Kaplan, Carolyn; Dahm, Johann; Oran, Elaine; Alexandrov, Natalia; Boris, Jay</p> <p>2011-01-01</p> <p>The Air Traffic Monotonic Lagrangian Grid (ATMLG) is used to simulate a 24 hour period of air traffic flow in the National Airspace System (NAS). During this time period, there are 41,594 flights over the United States, and the flight plan information (departure and arrival airports and times, and waypoints along the way) are obtained from an Federal Aviation Administration (FAA) Enhanced Traffic Management System (ETMS) dataset. Two simulation procedures are tested and compared: one based on the Monotonic Lagrangian Grid (MLG), and the other based on the stationary Latitude-Longitude (<span class="hlt">Lat</span>- Long) grid. Simulating one full day of air traffic over the United States required the following amounts of CPU time on a single processor of an SGI Altix: 88 s for the MLG method, and 163 s for the <span class="hlt">Lat</span>-Long grid method. We present a discussion of the amount of CPU time required for each of the simulation processes (updating aircraft trajectories, sorting, conflict detection and resolution, etc.), and show that the main advantage of the MLG method is that it is a general sorting algorithm that can sort on multiple properties. We discuss how many MLG neighbors must be considered in the separation assurance procedure in order to ensure a five-mile separation buffer between aircraft, and we investigate the effect of removing waypoints from aircraft trajectories. When aircraft choose their own trajectory, there are more flights with shorter duration times and fewer CD&R maneuvers, resulting in significant fuel savings.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014IAUS..303..414G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014IAUS..303..414G"><span>Dark matter and pulsar model constraints from Galactic center Fermi/<span class="hlt">LAT</span> γ-ray observations</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gordon, Chris; Macias, Oscar</p> <p>2014-05-01</p> <p>Employing Fermi/<span class="hlt">LAT</span> γ-ray observations, several independent groups have found excess extended γ-ray emission at the Galactic center (GC). Both, annihilating dark matter (DM) or a population of ~ 103 unresolved millisecond pulsars (MSPs) are regarded as well motivated possible explanations. However, there is significant uncertainties in the diffuse Galactic background at the GC. We have performed a revaluation of these two models for the extended γ-ray source at the GC by accounting for the systematic uncertainties of the Galactic diffuse emission model. We also marginalize over point source and diffuse background parameters in the region of interest. We show that the excess emission is significantly more extended than a point source. We find that the DM (or pulsar population) signal is larger than the systematic errors and therefore proceed to determine the sectors of parameter space that provide an acceptable fit to the data. We found that a population of several thousand MSPs with parameters consistent with the average spectral shape of Fermi/<span class="hlt">LAT</span> measured MSPs was able to fit the GC excess emission. For DM, we found that a pure τ+τ- annihilation channel is not a good fit to the data. But a mixture of τ+τ- and b<overline>b</overline> with a <σ v> of order the thermal relic value and a DM mass of around 20 to 60 GeV provides an adequate fit.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013PhRvD..88h3521G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013PhRvD..88h3521G"><span>Dark matter and pulsar model constraints from Galactic Center Fermi-<span class="hlt">LAT</span> gamma-ray observations</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gordon, Chris; Macías, Oscar</p> <p>2013-10-01</p> <p>Employing Fermi-<span class="hlt">LAT</span> gamma-ray observations, several independent groups have found excess extended gamma-ray emission at the Galactic Center (GC). Both annihilating dark matter (DM) or a population of ˜103 unresolved millisecond pulsars (MSPs) are regarded as well-motivated possible explanations. However, there are significant uncertainties in the diffuse galactic background at the GC. We have performed a revaluation of these two models for the extended gamma-ray source at the GC by accounting for the systematic uncertainties of the Galactic diffuse emission model. We also marginalize over point-source and diffuse background parameters in the region of interest. We show that the excess emission is significantly more extended than a point source. We find that the DM (or pulsar-population) signal is larger than the systematic errors and therefore proceed to determine the sectors of parameter space that provide an acceptable fit to the data. We find that a population of 1000-2000 MSPs with parameters consistent with the average spectral shape of Fermi-<span class="hlt">LAT</span> measured MSPs is able to fit the GC excess emission. For DM, we find that a pure τ+τ- annihilation channel is not a good fit to the data. But a mixture of τ+τ- and bb¯ with a ⟨σv⟩ of order the thermal relic value and a DM mass of around 20 to 60 GeV provides an adequate fit.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.osti.gov/biblio/21474410-eight-gamma-ray-pulsars-discovered-blind-frequency-searches-fermi-lat-data','SCIGOV-STC'); return false;" href="https://www.osti.gov/biblio/21474410-eight-gamma-ray-pulsars-discovered-blind-frequency-searches-fermi-lat-data"><span>EIGHT {gamma}-RAY PULSARS DISCOVERED IN BLIND FREQUENCY SEARCHES OF FERMI <span class="hlt">LAT</span> DATA</span></a></p> <p><a target="_blank" href="http://www.osti.gov/search">DOE Office of Scientific and Technical Information (OSTI.GOV)</a></p> <p>Saz Parkinson, P. M.; Dormody, M.; Ziegler, M.</p> <p>2010-12-10</p> <p>We report the discovery of eight {gamma}-ray pulsars in blind frequency searches of {approx}650 source positions using the Large Area Telescope (<span class="hlt">LAT</span>), on board the Fermi Gamma-ray Space Telescope. We present the timing models, light curves, and detailed spectral parameters of the new pulsars. PSRs J1023-5746, J1044-5737, J1413-5205, J1429-5911, and J1954+2836 are young ({tau}{sub c} < 100 kyr), energetic (E-dot {approx}>10{sup 36} erg s{sup -1}), and located within the Galactic plane (|b| < 3{sup 0}). The remaining three pulsars, PSRs J1846+0919, J1957+5033, and J2055+25, are less energetic, and located off the plane. Five pulsars are associated with sources included inmore » the Fermi-<span class="hlt">LAT</span> bright {gamma}-ray source list, but only one, PSR J1413-6205, is clearly associated with an EGRET source. PSR J1023-5746 has the smallest characteristic age ({tau}{sub c} = 4.6 kyr) and is the most energetic (E-dot = 1.1x10{sup 37} erg s{sup -1}) of all {gamma}-ray pulsars discovered so far in blind searches. By analyzing >100 ks of publicly available archival Chandra X-ray data, we have identified the likely counterpart of PSR J1023-5746 as a faint, highly absorbed source, CXOU J102302.8-574606. The large X-ray absorption indicates that this could be among the most distant {gamma}-ray pulsars detected so far. PSR J1023-5746 is positionally coincident with the TeV source HESS J1023-575, located near the young stellar cluster Westerlund 2, while PSR J1954+2836 is coincident with a 4.3{sigma} excess reported by Milagro at a median energy of 35 TeV. PSRs J1957+5033 and J2055+25 have the largest characteristic ages ({tau}{sub c} {approx} 1 Myr) and are the least energetic (E-dot {approx}5x10{sup 33} erg s{sup -1}) of the newly discovered pulsars. We used recent XMM observations to identify the counterpart of PSR J2055+25 as XMMU J205549.4+253959. Deep radio follow-up observations of the eight pulsars resulted in no detections of pulsations and upper limits comparable to the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title50-vol13/pdf/CFR-2014-title50-vol13-part660-app2c.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title50-vol13/pdf/CFR-2014-title50-vol13-part660-app2c.pdf"><span>50 CFR Table 2c to Part 660... - Sablefish North of 36° N. <span class="hlt">lat</span>. Allocations, 2014 and Beyond</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Sablefish North of 36° N. <span class="hlt">lat</span>. Allocations, 2014 and Beyond 2c Table 2c to Part 660, Subpart C Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_25 --> <div class="footer-extlink text-muted" style="margin-bottom:1rem; text-align:center;">Some links on this page may take you to non-federal websites. 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