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Sample records for le calorimetre electromagnetique

  1. Quantification du champ electromagnetique et description quantique de la generation du second harmonique a l'interieur d'une microcavite

    NASA Astrophysics Data System (ADS)

    Collette, Marc

    L'existence de particules virtuelles qui surgissent spontanement du vide pour disparaitre tres peu de temps apres leur apparition (les fluctuations du vide) trouve son origine dans le principe d'incertitude de Heisenberg. Par ailleurs, on sait que le phenomene de resonance par confinement explique l'amplification de l'intensite lumineuse a l'interieur d'une cavite ouverte aux frequences de resonances de celle-ci. C'est pourquoi le taux d'apparition des photons virtuels au sein des modes propres d'une cavite est lui aussi amplifie par le resonateur. Mathematiquement, cet effet quantique est decrit par l'existence d'un commutateur " anomal " entre les operateurs d'annihilation et de creation des photons. Nous decrivons les consequences de ce commutateur sur la generation du second harmonique optique (GSH), un processus photonique ou, dans un materiau optiquement non lineaire, deux photons de meme energie fusionnent pour n'en former qu'un seul. On commence ce travail avec un traitement complet et original sur la quantification du champ electromagnetique. On montre ensuite que les fluctuations du vide stimulent le signal de la GSH a l'interieur du milieu confine. Cependant, on constate aussi que les fluctuations du vide jouent le role d'un inhibiteur au declenchement du processus, c'est-a-dire que le seuil de la GSH augmente (il est superieur au seuil minimal de deux photons seulement). En conclusion, les mecanismes intimes de certains processus optiques non lineaires doivent etre reconsideres lorsqu'ils surviennent en presence d'un confinement electromagnetique.

  2. Device for calorimetric measurement

    DOEpatents

    King, William P; Lee, Jungchul

    2015-01-13

    In one aspect, provided herein is a single crystal silicon microcalorimeter, for example useful for high temperature operation and long-term stability of calorimetric measurements. Microcalorimeters described herein include microcalorimeter embodiments having a suspended structure and comprising single crystal silicon. Also provided herein are methods for making calorimetric measurements, for example, on small quantities of materials or for determining the energy content of combustible material having an unknown composition.

  3. Calorimetric gas sensor

    DOEpatents

    Ricco, A.J.; Hughes, R.C.; Smith, J.H.; Moreno, D.J.; Manginell, R.P.; Senturia, S.D.; Huber, R.J.

    1998-11-10

    A combustible gas sensor is described that uses a resistively heated, noble metal-coated, micromachined polycrystalline Si filament to calorimetrically detect the presence and concentration of combustible gases. The filaments tested to date are 2 {micro}m thick {times} 10{micro}m wide {times} 100, 250, 500, or 1000 {micro}m-long polycrystalline Si; some are overcoated with a 0.25 {micro}m-thick protective CVD Si{sub 3}N{sub 4} layer. A thin catalytic Pt film was deposited by CVD from the precursor Pt(acac){sub 2} onto microfilaments resistively heated to approximately 500 C; Pt deposits only on the hot filament. Using a constant-resistance-mode feedback circuit, Pt-coated filaments operating at ca. 300 C (35 mW input power) respond linearly, in terms of the change in supply current required to maintain constant resistance (temperature), to H{sub 2} concentrations between 100 ppm and 1% in an 80/20 N{sub 2}/O{sub 2} mixture. Other catalytic materials can also be used. 11 figs.

  4. Calorimetric gas sensor

    DOEpatents

    Ricco, Antonio J.; Hughes, Robert C.; Smith, James H.; Moreno, Daniel J.; Manginell, Ronald P.; Senturia, Stephen D.; Huber, Robert J.

    1998-01-01

    A combustible gas sensor that uses a resistively heated, noble metal-coated, micromachined polycrystalline Si filament to calorimetrically detect the presence and concentration of combustible gases. The filaments tested to date are 2 .mu.m thick.times.10 .mu.m wide.times.100, 250, 500, or 1000 .mu.m-long polycrystalline Si; some are overcoated with a 0.25 .mu.m-thick protective CVD Si.sub.3 N.sub.4 layer. A thin catalytic Pt film was deposited by CVD from the precursor Pt(acac).sub.2 onto microfilaments resistively heated to approximately 500.degree. C.; Pt deposits only on the hot filament. Using a constant-resistance-mode feedback circuit, Pt-coated filaments operating at ca. 300.degree. C. (35 mW input power) respond linearly, in terms of the change in supply current required to maintain constant resistance (temperature), to H.sub.2 concentrations between 100 ppm and 1% in an 80/20 N.sub.2 /O.sub.2 mixture. Other catalytic materials can also be used.

  5. Calorimetric thermobarometry of experimentally shocked quartz

    NASA Technical Reports Server (NTRS)

    Ocker, Katherine D.; Gooding, James L.; Hoerz, Friedrich

    1994-01-01

    Structural damage in experimentally shock-metamorphosed, granular quartz is quantitatively measurable by differential scanning calorimetry (DSC). Shock-induced loss of crystallinity is witnessed by disappearance of the alpha/beta phase transformation and evolution of a broad endoenthalpic strain peak at 650-900 K. The strain-energy peak grows rapidly at less than 10 GPa but declines with increasing shock pressure; it approaches zero at 32 GPa where vitrification is extensive. Effects of grain size and post-shock thermal history must be better understood before calorimetric thermobarometry of naturally shocked samples becomes possible.

  6. Calorimetric and Magnetic Study of the Holmium

    NASA Astrophysics Data System (ADS)

    Henry, Laurence L.

    Calorimetric measurements have been performed on a series of cubic Laves phase compounds Ho(Co _{rm 1-x}Rh_ {rm x})_2 for x = 0.02, 0.05, 0.08, 0.12, 0.16, and 0.25. The heat capacity data show first-order type peaks at the ferromagnetic transition temperature T_{rm c} for concentrations with x- values between 0.02 and 0.08. For larger concentrations, the peaks at T_{rm c} are much broader and more suggestive of a second-order transition. Utilizing the "s-d" model in conjunction with the specific heat data suggests that the change from first- to second-order in the ferromagnetic transition for x _sp{ ~}{>} 0.10 is due to a reduction in the magnetic exchange interactions between the Ho 4f moments and the cobalt 3d electrons. In addition, the calorimetric data for x <=q 0.16 show another first-order peak at a lower temperature T _{rm sf} which can be associated with a change in the easy magnetization direction of the Ho moments.

  7. New calorimetric all-particle energy spectrum

    NASA Technical Reports Server (NTRS)

    Linsley, J.

    1985-01-01

    Both the maximum size N sub m and the sea level muon size N sub mu have been used separately to find the all-particle energy spectrum in the air shower domain. However the conversion required, whether from N sub m to E or from N sub mu to E, has customarily been carried out by means of calculations based on an assumed cascase model. It is shown here that by combining present data on N sub m and N sub mu spectra with data on: (1); the energy spectrum of air shower muons and (2) the average width of the electron profile, one can obtain empirical values of the N sub m to E and N sub mu to E conversion factors, and an empirical calorimetric all-particle spectrum, in the energy range 2 x 10 to the 6th power E 2 x 10 to the 9th power GeV.

  8. Radiation beam calorimetric power measurement system

    DOEpatents

    Baker, John; Collins, Leland F.; Kuklo, Thomas C.; Micali, James V.

    1992-01-01

    A radiation beam calorimetric power measurement system for measuring the average power of a beam such as a laser beam, including a calorimeter configured to operate over a wide range of coolant flow rates and being cooled by continuously flowing coolant for absorbing light from a laser beam to convert the laser beam energy into heat. The system further includes a flow meter for measuring the coolant flow in the calorimeter and a pair of thermistors for measuring the temperature difference between the coolant inputs and outputs to the calorimeter. The system also includes a microprocessor for processing the measured coolant flow rate and the measured temperature difference to determine the average power of the laser beam.

  9. Calorimetric study of peroxycarboxylic ester synthesis.

    PubMed

    Fritzsche, L; Knorr, A

    2009-04-30

    Exothermic reactions involving organic peroxides carry a high potential hazard and must be considered with care. A safe handling requires, among others, the assessment of thermal process safety, for which safety characteristics like overall heat production and the resulting adiabatic temperature rise are essential. The article presents the results of the calorimetric investigation of the synthesis of four peroxycarboxylic esters, three tert-Butyl and one tert-Amyl peroxycarboxylic ester. In the two-step synthesis the second one clearly shows the higher exothermic potential. The overall heat production lies in the range of 126-135 kJ/mol and is nearly independent of the carboxylic acid residual in the tert-Butyl peroxycarboxylic ester. The calculated adiabatic temperature rise is 70-80K. Influence of temperature and feed rate on the heat generation is discussed for one species. A grading of the synthesis with respect to temperature levels according to the criticality classes by Stoessel leads to the most critical for an exothermic reaction. PMID:18722058

  10. The CALorimetric Electron Telescope, CALET, Mission

    NASA Astrophysics Data System (ADS)

    Torii, Shoji

    We are developing the CALorimetric Electron Telescope, CALET, mission for the Japanese Experiment Module Exposed Facility, JEM-EF, of the International Space Station. Major scientific objectives are to search for nearby cosmic ray sources and dark matter by carrying out a precise measurement of the electrons in GeV 20 TeV and the gamma-rays in 20 MeV TeV. CALET has a unique capability to observe electrons and gamma-rays over 1 TeV since the hadron rejection power is more than 105 and the energy resolution better than a few percent over 100 GeV. The detector consists of an Imaging Calorimeter (IMC) with scintillating fiber belts and tungsten plates, a Total Absorption Calorimeter (TASC) with BGO logs, a Silicon Pixel Array (SIA) and a Scintillator Anti-Coincidence System (SACS). CALET has also a capability to measure protons and nuclei in 10 GeV 1000 TeV, and will have a function to monitor solar activity and gamma-ray bursts with additional instruments. The phase A study has started on a schedule of launch in 2013 by H-II Transfer Vehicle (HTV) for 5 years observation.

  11. Micro-calorimetric sensor for trace explosive particle detection

    NASA Astrophysics Data System (ADS)

    Olsen, Jesper K.; Greve, Anders; Privorotskaya, N.; Senesac, L.; Thundat, T.; King, W. P.; Boisen, A.

    2010-04-01

    A micro differential thermal analysis (DTA) system is used for detection of trace explosive particles. The DTA system consists of two silicon micro chips with integrated heaters and temperature sensors. One chip is used for reference and one for the measurement sample. The sensor is constructed as a small silicon nitride bridge incorporating heater elements and a temperature measurement resistor. In this manuscript the DTA system is described and tested by measuring calorimetric response of DNT (2,4-Dinitrotoluene). The design of the senor is described and the temperature uniformity investigated using finite element modelings and Raman temperature measurements. The functionality is tested using two different kinds of explosive deposition techniques and calorimetric responses are obtained. Under the framework of the Xsense project at the Technical University of Denmark (DTU) which combines four independent sensing techniques, these micro DNT sensors will be included in handheld explosives detectors with applications in homeland security and landmine clearance.

  12. Thermodynamic properties by non-calorimetric methods. Final report

    SciTech Connect

    Steele, W.V.; Chirico, R.D.; Collier, W.B.; Strube, M.M.; Klots, T.D. |

    1992-12-31

    This research program provided a valuable complement to the experimental programs currently in progress at NIPER for the Advanced Research and Technology Development (AR and TD) and Advanced Exploration and Process Technology (AEPT) divisions of the Department of Energy. These experimental programs are focused on the calorimetric determination of thermodynamic properties of key polynuclear heteroatom-containing aromatic molecules. The project for the Office of Energy Research focused on the non-calorimetric determination of thermodynamic properties through the extension of existing correlation methodologies and through molecular spectroscopy with statistical mechanics. The paper discusses the following studies: Group-contribution approach for polycyclic aromatic hydrocarbons (naphthalene, phenanthrene, anthracene, pyrene, 3-methylphenanthrene, benzoquinolines, biphenyl/hydrogen system); Group-contribution approach for key monocyclic organic compounds; Molecular spectroscopy and statistical mechanics; and Thermophysical property correlations.

  13. Measurement of the calorimetric energy scale in MINOS

    SciTech Connect

    Hartnell, Jeffrey J.

    2005-06-01

    MINOS is a long-baseline neutrino oscillation experiment. A neutrino beam is created at the Fermi National Accelerator Laboratory in Illinois and fired down through the Earth. Measurements of the energy spectra and composition of the neutrino beam are made both at the source using the Near detector and 735 km away at the Soudan Underground Laboratory in Minnesota using the Far detector. By comparing the spectrum and flavour composition of the neutrino beam between the two detectors neutrino oscillations can be observed. Such a comparison depends on the accuracy of the relative calorimetric energy scale. This thesis details a precise measurement of the calorimetric energy scale of the MINOS Far detector and Calibration detector using stopping muons with a new ''track window'' technique. These measurements are used to perform the relative calibration between the two detectors. This calibration has been accomplished to 1.7% in data and to significantly better than 2% in the Monte Carlo simulation, thus achieving the MINOS relative calibration target of 2%. A number of cross-checks have been performed to ensure the robustness of the calorimetric energy scale measurements. At the Calibration detector the test-beam energy between run periods is found to be consistent with the detector response to better than 2% after the relative calibration is applied. The muon energy loss in the MINOS detectors determined from Bethe-Bloch predictions, data and Monte Carlo are compared and understood. To estimate the systematic error on the measurement of the neutrino oscillation parameters caused by a relative miscalibration a study is performed. A 2% relative miscalibration is shown to cause a 0.6% bias in the values of {Delta}m{sup 2} and sin{sup 2}(2{theta}).

  14. A no-calorimetric method for measuring SAR in MRI

    NASA Astrophysics Data System (ADS)

    Romano, Rocco; Acernese, Fausto; Barone, Fabrizio

    2011-04-01

    During an MR procedure, the patient absorbs a portion of the transmitted RF energy, which may result in tissue heating and other adverse effects, such as alterations in visual, auditory and neural functions. The Specific Absorption Rate (SAR), in W/kg, is the RF power absorbed per unit mass of tissue and is one of the most important parameters related with thermal effects and acts as a guideline for MRI safety. Strict limits to the SAR levels are imposed by patient safety international regulations (CEI - EN 60601 - 2 - 33) and SAR measurements are required in order to verify its respect. The recommended methods for mean SAR measurement are quite problematic and often require a maintenance man intervention and long stop machine. For example, in the CEI recommended pulse energy method, the presence of a maintenance man is required in order to correctly connect the required instrumentation; furthermore, the procedure is complex and requires remarkable processing and calculus. Simpler are the calorimetric methods, also if in this case long acquisition times are required in order to have significant temperature variations and accurate heat capacity knowledge (CEI - EN 60601 - 2 - 33). The phase transition method is a new no-calorimetric method to measure SAR in MRI which has the advantages to be very simple and to overcome all the typical calorimetric method problems. It does not require in gantry temperature measurements, any specific heat or heat capacity knowledge, but only mass and time measurement. On the other hand, it is necessary to establish if all deposited power SAR can be considered acquired and measured. In this paper, that will be shown.

  15. The Level-0 calorimetric trigger of the NA62 experiment

    NASA Astrophysics Data System (ADS)

    Ammendola, R.; Barbanera, M.; Bizzarri, M.; Bonaiuto, V.; Ceccucci, A.; Checcucci, B.; De Simone, N.; Fantechi, R.; Federici, L.; Fucci, A.; Lupi, M.; Paoluzzi, G.; Papi, A.; Piccini, M.; Ryjov, V.; Salamon, A.; Salina, G.; Sargeni, F.; Venditti, S.

    2016-02-01

    The NA62 experiment at the CERN SPS aims at measuring the branching ratio of the very rare kaon decay K+ → π+ ν bar nu (expected 10-10) with a 10% background. Since an high-intensity kaon beam is required to collect enough statistics, the Level-0 trigger plays a fundamental role in both the background rejection and in the particle identification. The calorimetric trigger collects data from various calorimeters and it is able to identify clusters of energy deposit and determine their position, fine-time and energy. This paper describes the complete hardware commisioning and the setup of the trigger for the 2015 physics data taking.

  16. ASIC for calorimetric measurements in the astrophysical experiment NUCLEON

    NASA Astrophysics Data System (ADS)

    Atkin, E.; Voronin, A.; Karmanov, D.; Kudryashov, I.; Kovalev, I.; Shumikhin, V.

    2016-02-01

    A satellite with the NUCLEON apparatus was launched in Dec. 2014. The space NUCLEON project of ROSCOSMOS is designed to investigate cosmic ray nuclei energy spectra from 100 GeV to 1000 TeV as well as cosmic ray electron spectra from 20 GeV to 3 TeV. The method of energy determination by means of a silicon instrument for measuring the particle charge of cosmic rays and the calorimetric system were developed. The main parameters, that determine the quality of calorimetric systems are linearity of transfer characteristic and the dynamic range of input signals, which should reach 30 000 MIPs (minimum ionizing particles). The ASIC, satisfying these requirements, consisting of 32 channels with a unique dynamic range from 1 to 40000 MIPs, signal to noise ratio not less than 2.5 at a shaper peaking time of 2 μs and a low power consumption of 1.5 mW/channel has been designed. The first results of the ASIC functionality in space are presented.

  17. Adiabatic calorimetric decomposition studies of 50 wt.% hydroxylamine/water.

    PubMed

    Cisneros, L O; Rogers, W J; Mannan, M S

    2001-03-19

    Calorimetric data can provide a basis for determining potential hazards in reactions, storage, and transportation of process chemicals. This work provides calorimetric data for the thermal decomposition behavior in air of 50wt.% hydroxylamine/water (HA), both with and without added stabilizers, which was measured in closed cells with an automatic pressure tracking adiabatic calorimeter (APTAC). Among the data provided are onset temperatures, reaction order, activation energies, pressures of noncondensable products, thermal stability at 100 degrees C, and the effect of HA storage time. Discussed also are the catalytic effects of carbon steel, stainless steel, stainless steel with silica coating, inconel, titanium, and titanium with silica coating on the reaction self-heat rates and onset temperatures. In borosilicate glass cells, HA was relatively stable at temperatures up to 133 degrees C, where the HA decomposition self-heat rate reached 0.05 degrees C/min. The added stabilizers appeared to reduce HA decomposition rates in glass cells and at ambient temperatures. The tested metals and metal surfaces coated with silica acted as catalysts to lower the onset temperatures and increase the self-heat rates. PMID:11165058

  18. Novel micro-calorimetric spectroscopy for mine detection

    SciTech Connect

    Datskos, P.G. |; Rajic, S.; Egert, C.M.; Datskou, I.

    1998-03-01

    The authors have developed a novel micro-calorimetric spectroscopy technique that can be used in mine detection applications. In this technique target molecules are allowed to adsorb on the surface of sub-femtojoule sensitive micromechanical thermal detectors. The adsorption of molecules on the thermal detector surface causes a differential surface stress resulting in an initial trigger. By exposing each element in an array of thermal detectors to different photon wavelengths, an extremely sensitive and unique photothermal signature response can be obtained. The authors present their results on target chemicals adsorbed on the detector surface at sub-monolayer coverage levels. They will present infrared photothermal spectra for trace concentrations of diisopropyl methylphosphonate (DIMP), and trinitrotoluene (TNT) over the wavelength region 2.5 to 14.5 microns. They found that in the wavelength region 2.5 to 14.5 microns the photothermal spectra of DIMP and TNT exhibit a number of peaks and are in excellent agreement with infrared absorption spectra found in the literature. Chemical detectors based on micro-calorimetric spectroscopy can be used to sensitively sense small number of molecules adsorbed on a thermal detector surface. The photothermal signature resulting from photon irradiation can be used for improved chemical characterization.

  19. Determination of Nuclear Charge Distributions of Fission Fragments from ^{235}U (n_th, f) with Calorimetric Low Temperature Detectors

    NASA Astrophysics Data System (ADS)

    Grabitz, P.; Andrianov, V.; Bishop, S.; Blanc, A.; Dubey, S.; Echler, A.; Egelhof, P.; Faust, H.; Gönnenwein, F.; Gomez-Guzman, J. M.; Köster, U.; Kraft-Bermuth, S.; Mutterer, M.; Scholz, P.; Stolte, S.

    2016-08-01

    Calorimetric low temperature detectors (CLTD's) for heavy-ion detection have been combined with the LOHENGRIN recoil separator at the ILL Grenoble for the determination of nuclear charge distributions of fission fragments produced by thermal neutron-induced fission of ^{235}U. The LOHENGRIN spectrometer separates fission fragments according to their mass-to-ionic-charge ratio and their kinetic energy, but has no selectivity with respect to nuclear charges Z. For the separation of the nuclear charges, one can exploit the nuclear charge-dependent energy loss of the fragments passing through an energy degrader foil (absorber method). This separation requires detector systems with high energy resolution and negligible pulse height defect, as well as degrader foils which are optimized with respect to thickness, homogeneity, and energy loss straggling. In the present, contribution results of test measurements at the Maier Leibnitz tandem accelerator facility in Munich with ^{109}Ag and ^{127}I beams with the aim to determine the most suitable degrader material, as well as measurements at the Institut Laue-Langevin will be presented. These include a systematic study of the quality of Z-separation of fission fragments in the mass range 82le A le 132 and a systematic measurement of ^{92}Rb fission yields, as well as investigations of fission yields toward the symmetry region.

  20. Calorimetric study of tellurium rich Se-Te-Sn glasses

    NASA Astrophysics Data System (ADS)

    Heera, Pawan; Kumar, Anup; Jharwal, Manish; Sharma, Raman

    2016-05-01

    We report the calorimetric study of amorphous Se30Te70-x Snx alloys for x= 0, 1.5, 2.5, 4.5 in terms of kinetic parameters. The DSC curves recorded at four different heating rates are analyzed to determine the transition temperatures, activation energy, thermal stability, glass forming ability. The crystallization process has been investigated using Kissinger, Matusita, Augis and Bennett, and Gao and Wang models. Various kinetic parameters have been calculated for a better understanding of the growth mechanism. The glass transition temperatures Tg, onset crystallization Tc, peak crystallization Tp, and melting temperature Tm are found to increase with the increase in Sn content. The system under investigation is found to be thermally stable for at lower at% of Sn. The values of parameters HR, Hw, and S indicate that Glass forming ability (GFA) decays with an increase in Sn content.

  1. Preparation, structural, and calorimetric characterization of bicomponent metallic photonic crystals

    NASA Astrophysics Data System (ADS)

    Kozlov, M. E.; Murthy, N. S.; Udod, I.; Khayrullin, I. I.; Baughman, R. H.; Zakhidov, A. A.

    2007-03-01

    We report preparation and characterization of novel bicomponent metal-based photonic crystals having submicron three-dimensional (3D) periodicity. Fabricated photonic crystals include SiO2 sphere lattices infiltrated interstitially with metals, carbon inverse lattices filled with metal or metal alloy spheres, Sb inverse lattices, and Sb inverse lattices filled with Bi spheres. Starting from a face centered SiO2 lattice template, these materials were obtained by sequences of either templating and template extraction or templating, template extraction, and retemplating. Surprising high fidelity was obtained for all templating and template extraction steps. Scanning electron microscopy (SEM), small angle X-ray scattering (SAXS) and differential scanning calorimetry (DSC) were used to characterize the structure and the effects of the structure on calorimetric properties. To the best of our knowledge, SAXS data on metallic photonic crystals were collected for first time.

  2. Calorimetric determination of the enthalpy of formation for pyrophyllite

    NASA Astrophysics Data System (ADS)

    Ogorodova, L. P.; Kiseleva, I. A.; Mel'Chakova, L. V.; Vigasina, M. F.; Spiridonov, E. M.

    2011-09-01

    A calorimetric study of the natural pyrophyllite was performed by high-temperature melt calorimetry on a Tian-Calvet calorimeter. Based on experimentally determined in this work for pyrophyllite and gibbsite, as well as previously obtained for corundum and quartz, the total value of the enthalpy increment for the sample heated from room temperature to 973 K and the enthalpy of dissolution at 973 K by Hess's law, the enthalpy of formation of pyrophyllite of Al2[(OH)2/Si4O10] composed of elements was calculated at 298.15 K: Δf H {el/o}(298.15 K) = -5639.8 ± 5.7 kJ/mol.

  3. Nanoclay modified polycarbonate blend nanocomposites: Calorimetric and mechanical properties

    NASA Astrophysics Data System (ADS)

    Zicans, Janis; Meri, Remo Merijs; Ivanova, Tatjana; Berzina, Rita; Kalnins, Martins; Maksimovs, Roberts

    2014-05-01

    The research is devoted to characterization of polycarbonate (PC)/acrylonitrile-butadiene styrene (ABS) blend nanocomposites in respects to it mechanical and calorimetric properties. It is shown that PC blend with 10wt% of ABS is more suitable for development of polymer-clay nanocomposites than PC blend with 40wt.% of ABS. It is revealed that the greatest modulus and strength increment is observed for PC/10wt.%ABS blend nanocomposites, containing aromatic organomodifier treated clay (Dellite 43B). It is also determined that optimal nanofiller content for the investigated PC/10%ABS blend is 1.5 wt.%. Increase of mechanical characteristics of PC/10wt.%ABS blend nanocomposites is accompanied with the rise of glass transition temperatures of both polymeric phases, particularly that of PC.

  4. Remote calorimetric detection of urea via flow injection analysis.

    PubMed

    Gaddes, David E; Demirel, Melik C; Reeves, W Brian; Tadigadapa, Srinivas

    2015-12-01

    The design and development of a calorimetric biosensing system enabling relatively high throughput sample analysis are reported. The calorimetric biosensor system consists of a thin (∼20 μm) micromachined Y-cut quartz crystal resonator (QCR) as a temperature sensor placed in close proximity to a fluidic chamber packed with an immobilized enzyme. Layer by layer enzyme immobilization of urease is demonstrated and its activity as a function of the number of layers, pH, and time has been evaluated. This configuration enables a sensing system where a transducer element is physically separated from the analyte solution of interest and is thereby free from fouling effects typically associated with biochemical reactions occuring on the sensor surface. The performance of this biosensing system is demonstrated by detection of 1-200 mM urea in phosphate buffer via a flow injection analysis (FIA) technique. Miniaturized fluidic systems were used to provide continuous flow through a reaction column. Under this configuration the biosensor has an ultimate resolution of less than 1 mM urea and showed a linear response between 0-50 mM. This work demonstrates a sensing modality in which the sensor itself is not fouled or contaminated by the solution of interest and the enzyme immobilized Kapton® fluidic reaction column can be used as a disposable cartridge. Such a system enables reuse and reliability for long term sampling measurements. Based on this concept a biosensing system is envisioned which can perform rapid measurements to detect biomarkers such as glucose, creatinine, cholesterol, urea and lactate in urine and blood continuously over extended periods of time. PMID:26479269

  5. A calorimetric investigation of spessartine: Vibrational and magnetic heat capacity

    NASA Astrophysics Data System (ADS)

    Dachs, Edgar; Geiger, Charles A.; Withers, Anthony C.; Essene, Eric J.

    2009-06-01

    The heat capacity ( Cp) of two synthetic spessartine samples (Sps) was measured on 20-30 mg-size samples in the temperature range 2-864 K by relaxation calorimetry (RC) and differential scanning calorimetry (DSC). The polycrystalline spessartine samples were synthesized in two different laboratories at high pressures and temperatures from glass and oxide-mixture starting materials and characterized by X-ray powder diffraction and electron-microprobe analysis. The low-temperature heat capacity data show a prominent lambda transition with a peak at 6.2 K, which is interpreted to be the result of a paramagnetic-antiferromagnetic phase transition. The DSC data around ambient T agree excellently with the RC data and can be represented by the Cp polynomial for T > 250 K: CpSps=610-3060·T-0.5-1.45·107·T-2+1.82·109·T-3. Integration of the low temperature Cp data yields a calorimetric standard entropy for the two different samples of So = 334.6 ± 2.7 J/mol · K and 336.0 ± 2.7 J/mol · K. The preferred standard third-law entropy for spessartine is So = 335.3 ± 3.8 J/mol · K, which is the mean value from the two separate determinations. The lattice (vibrational) heat capacity of spessartine was calculated using the single-parameter phonon dispersion model of Komada and Westrum. The lattice entropy at 298.15 K is Svib298.15=297.7J/mol·K, which represents 89% of the calorimetric entropy. The magnetic heat capacity and entropy of spessartine, Smag, at 298.15 K were also calculated. The Smag of the two samples is 38.7 and 37.4 J/mol · K, which is 87% and 83% of the maximum possible magnetic entropy given by 3Rln6 = 44.7 J/mol · K. Published model-dependent lattice-dynamic calculations of Svib298.15 are analyzed and compared to the experimental data. Using the calorimetrically determined So and the Cp polynomial for spessartine, together with high P- T experimental phase-equilibrium data on Mn 2+-Mg partitioning between garnet and olivine, allows calculation of the

  6. Calorimetric and relaxation properties of xylitol-water mixtures

    NASA Astrophysics Data System (ADS)

    Elamin, Khalid; Sjöström, Johan; Jansson, Helén; Swenson, Jan

    2012-03-01

    We present the first broadband dielectric spectroscopy (BDS) and differential scanning calorimetry study of supercooled xylitol-water mixtures in the whole concentration range and in wide frequency (10-2-106 Hz) and temperature (120-365 K) ranges. The calorimetric glass transition, Tg, decreases from 247 K for pure xylitol to about 181 K at a water concentration of approximately 37 wt. %. At water concentrations in the range 29-35 wt. % a plentiful calorimetric behaviour is observed. In addition to the glass transition, almost simultaneous crystallization and melting events occurring around 230-240 K. At higher water concentrations ice is formed during cooling and the glass transition temperature increases to a steady value of about 200 K for all higher water concentrations. This Tg corresponds to an unfrozen xylitol-water solution containing 20 wt. % water. In addition to the true glass transition we also observed a glass transition-like feature at 220 K for all the ice containing samples. However, this feature is more likely due to ice dissolution [A. Inaba and O. Andersson, Thermochim. Acta, 461, 44 (2007)]. In the case of the BDS measurements the presence of water clearly has an effect on both the cooperative α-relaxation and the secondary β-relaxation. The α-relaxation shows a non-Arrhenius temperature dependence and becomes faster with increasing concentration of water. The fragility of the solutions, determined by the temperature dependence of the α-relaxation close to the dynamic glass transition, decreases with increasing water content up to about 26 wt. % water, where ice starts to form. This decrease in fragility with increasing water content is most likely caused by the increasing density of hydrogen bonds, forming a network-like structure in the deeply supercooled regime. The intensity of the secondary β-relaxation of xylitol decreases noticeably already at a water content of 2 wt. %, and at a water content above 5 wt. % it has been replaced by a

  7. Estimation of the diversity between DNA calorimetric profiles, differential melting curves and corresponding melting temperatures.

    PubMed

    Chang, Chun-Ling; Fridman, Alexander S; Grigoryan, Inessa E; Galyuk, Elena N; Murashko, Oleg N; Hu, Chin-Kun; Lando, Dmitri Y

    2016-11-01

    The Poland-Fixman-Freire formalism was adapted for modeling of calorimetric DNA melting profiles, and applied to plasmid pBR 322 and long random sequences. We studied the influence of the difference (HGC -HAT ) between the helix-coil transition enthalpies of AT and GC base pairs on the calorimetric melting profile and on normalized calorimetric melting profile. A strong alteration of DNA calorimetrical profile with HGC -HAT was demonstrated. In contrast, there is a relatively slight change in the normalized profiles and in corresponding ordinary (optical) normalized differential melting curves (DMCs). For fixed HGC -HAT , the average relative deviation (S) between DMC and normalized calorimetric profile, and the difference between their melting temperatures (Tcal -Tm ) are weakly dependent on peculiarities of the multipeak fine structure of DMCs. At the same time, both the deviation S and difference (Tcal -Tm ) enlarge with the temperature melting range of the helix-coil transition. It is shown that the local deviation between DMC and normalized calorimetric profile increases in regions of narrow peaks distant from the melting temperature. PMID:27422497

  8. Fructose-selective calorimetric biosensor in flow injection analysis.

    PubMed

    Bhand, Sunil G; Soundararajan, Srimathi; Surugiu-Wärnmark, Ioana; Milea, Jaqueline Simona; Dey, Estera Szwajcer; Yakovleva, Maria; Danielsson, Bengt

    2010-05-23

    A highly selective, interference free biosensor for the measurement of fructose in real syrup samples was developed. The assay is based on the phosphorylation of D(-)fructose to fructose-6-phosphate by hexokinase and subsequent conversion of fructose-6-phosphate to fructose-1,6-biphosphate by fructose-6-phosphate-kinase. The heat liberated in the second reaction is monitored using an enzyme thermistor. The major advantages of this biosensor are rapid and selective measurement of fructose without the need to eliminate glucose and inexpensive FIA-based, mediator-free calorimetric measurement suitable for regular fructose analysis. This method was optimised for parameters, such as pH, ionic strength, interference, operational stability and shelf life. Good and reproducible linearity (0.5-6.0 mM) with a detection limit of 0.12 mM was obtained. Fructose determination in commercial syrup samples and spiked samples confirmed the reliability of this set-up and technique. The biosensor gave reproducible results with good overall stability for continuous measurements over a period of three months besides a useful shelf life of six months. The method could be used for routine fructose monitoring in food samples. PMID:20457296

  9. Differential scanning calorimetric studies of nickel titanium rotary endodontic instruments.

    PubMed

    Brantley, W A; Svec, T A; Iijima, M; Powers, J M; Grentzer, T H

    2002-08-01

    Differential scanning calorimetric (DSC) analyses were performed between -130 degrees and 100 degrees C on specimens prepared from nickel-titanium (NiTi) rotary endodontic instruments: ProFile (n = 5), Lightspeed (n = 4), and Quantec (n = 3). The ProFile and Lightspeed instruments were in the as-received condition, whereas the Quantec instruments were randomly selected from a dental clinic and had unknown history. The DSC plots showed that the ProFile and Lightspeed instruments analyzed had the superelastic NiTi property, with an austenite-finish (Af) temperature of approximately 25 degrees C. Differences in DSC plots for the ProFile instruments and the starting wire blanks (n = 2) were attributed to the manufacturing process. The phase transformation behavior when the specimens were heated and cooled between -130 degrees and 100 degrees C, the temperature ranges for the phase transformations, and the resulting enthalpy changes were similar to those previously reported for nickel-titanium orthodontic wires having superelastic characteristics or shape memory behavior in the oral environment. The experiments demonstrated that DSC is a powerful tool for materials characterization of these rotary instruments, providing direct information not readily available from other analytical techniques about the NiTi phases present, which are fundamentally responsible for their clinical behavior. PMID:12184415

  10. Adiabatic Heat of Hydration Calorimetric Measurements for Reference Saltstone Waste

    SciTech Connect

    Bollinger, James

    2006-01-12

    The production of nuclear materials for weapons, medical, and space applications from the mid-1950's through the late-1980's at the Savannah River Site (SRS) generated approximately 35 million gallons of liquid high-level radioactive waste, which is currently being processed into vitrified glass for long-term storage. Upstream of the vitrification process, the waste is separated into three components: high activity insoluble sludge, high activity insoluble salt, and very low activity soluble salts. The soluble salt represents 90% of the 35 million gallons of overall waste and is processed at the SRS Saltstone Facility, where it mixed with cement, blast furnace slag, and flyash, creating a grout-like mixture. The resulting grout is pumped into aboveground storage vaults, where it hydrates into concrete monoliths, called saltstone, thus immobilizing the low-level radioactive salt waste. As the saltstone hydrates, it generates heat that slowly diffuses out of the poured material. To ensure acceptable grout properties for disposal and immobilization of the salt waste, the grout temperature must not exceed 95 C during hydration. Adiabatic calorimetric measurements of the heat generated for a representative sample of saltstone were made to determine the time-dependent heat source term. These measurements subsequently were utilized as input to a numerical conjugate heat transfer model to determine the expected peak temperatures for the saltstone vaults.

  11. Thermodynamic properties of chlorite and berthierine derived from calorimetric measurements

    NASA Astrophysics Data System (ADS)

    Blanc, Philippe; Gailhanou, Hélène; Rogez, Jacques; Mikaelian, Georges; Kawaji, Hitoshi; Warmont, Fabienne; Gaboreau, Stéphane; Grangeon, Sylvain; Grenèche, Jean-Marc; Vieillard, Philippe; Fialips, Claire I.; Giffaut, Eric; Gaucher, Eric C.; Claret, F.

    2014-09-01

    In the context of the deep waste disposal, we have investigated the respective stabilities of two iron-bearing clay minerals: berthierine ISGS from Illinois [USA; (Al0.975FeIII0.182FeII1.422Mg0.157Li0.035Mn0.002)(Si1.332Al0.668)O5(OH)4] and chlorite CCa-2 from Flagstaff Hill, California [USA; (Si2.633Al1.367)(Al1.116FeIII0.215Mg2.952FeII1.712Mn0.012Ca0.011)O10(OH)8]. For berthierine, the complete thermodynamic dataset was determined at 1 bar and from 2 to 310 K, using calorimetric methods. The standard enthalpies of formation were obtained by solution-reaction calorimetry at 298.15 K, and the heat capacities were measured by heat-pulse calorimetry. For chlorite, the standard enthalpy of formation is measured by solution-reaction calorimetry at 298.15 K. This is completing the entropy and heat capacity obtained previously by Gailhanou et al. (Geochim Cosmochim Acta 73:4738-4749, 2009) between 2 and 520 K, by using low-temperature adiabatic calorimetry and differential scanning calorimetry. For both minerals, the standard entropies and the Gibbs free energies of formation at 298.15 K were then calculated. An assessment of the measured properties could be carried out with respect to literature data. Eventually, the thermodynamic dataset allowed realizing theoretical calculations concerning the berthierine to chlorite transition. The latter showed that, from a thermodynamic viewpoint, the main factor controlling this transition is probably the composition of the berthierine and chlorite minerals and the nature of the secondary minerals rather than temperature.

  12. Calorimetric method for determination of {sup 51}Cr neutrino source activity

    SciTech Connect

    Veretenkin, E. P. Gavrin, V. N.; Danshin, S. N.; Ibragimova, T. V.; Kozlova, Yu. P.; Mirmov, I. N.

    2015-12-15

    Experimental study of nonstandard neutrino properties using high-intensity artificial neutrino sources requires the activity of the sources to be determined with high accuracy. In the BEST project, a calorimetric system for measurement of the activity of high-intensity (a few MCi) neutrino sources based on {sup 51}Cr with an accuracy of 0.5–1% is created. In the paper, the main factors affecting the accuracy of determining the neutrino source activity are discussed. The calorimetric system design and the calibration results using a thermal simulator of the source are presented.

  13. Heat capacty, relative enthalpy, and calorimetric entropy of silicate minerals: an empirical method of prediction.

    USGS Publications Warehouse

    Robinson, G.R., Jr.; Haas, J.L., Jr.

    1983-01-01

    Through the evaluation of experimental calorimetric data and estimates of the molar isobaric heat capacities, relative enthalpies and entropies of constituent oxides, a procedure for predicting the thermodynamic properties of silicates is developed. Estimates of the accuracy and precision of the technique and examples of its application are also presented. -J.A.Z.

  14. The calorimetric spectrum of the electron-capture decay of 163Ho. The spectral endpoint region

    NASA Astrophysics Data System (ADS)

    De Rújula, A.; Lusignoli, M.

    2016-05-01

    The electron-neutrino mass (or masses and mixing angles) may be directly measurable in weak electron-capture decays. The favoured experimental technique is "calorimetric". The optimal nuclide is 163Ho, and several experiments (ECHo, HOLMES and NuMECS) are currently studying its decay. The most relevant range of the calorimetric-energy spectrum extends for the last few hundred eV below its endpoint. It has not yet been well measured. We explore the theory, mainly in the cited range, of electron capture in 163Ho decay. A so far neglected process turns out to be most relevant: electron-capture accompanied by the shake-off of a second electron. Our two main conclusions are very encouraging: the counting rate close to the endpoint may be more than an order of magnitude larger than previously expected; the "pile-up" problem may be significantly reduced.

  15. An Improved Formulation for Calorimetric Emittance Testing of Spacecraft Thermal Control Coatings

    NASA Technical Reports Server (NTRS)

    Kauder, Lonny R.

    2008-01-01

    Spacecraft often really heavily on passive thermal control to maintain operating temperature. An important parameter in the spacecraft heat balance equation is the emittance of thermal control coatings as a function of coating temperature. One method for determining the emittance of spacecraft thermal control from elevated temperature to cryogenic temperatures relies on a calorimetric technique. The fundamental equation governing this test method can be found in numerous places in the literature and although it generally provides reasonable results, its formulation is based on a conceptual flaw that only becomes apparent when the sample temperature approaches the wall temperature during testing. This paper investigates the cause for this error and develops the correct formulation for calorimetric emittance testing. Experimental data will also be presented that illustrates the difference between the two formulations and the resulting difference in the calculated emittance.

  16. GYROTRON POWER BALANCE BASED ON CALORIMETRIC MEASUREMENTS IN THE DIII-D ECH SYSTEM

    SciTech Connect

    GORELOV,I.A; LOHR,J.M; BAITY,JR.,F.W; CAHALAN,P; CALLIS,R.W; PONCE,D; CHIU,H.K

    2003-10-01

    OAK-B135 A powerful microwave system operating at the second harmonic of the electron cyclotron frequency on the DIII-D tokamak was upgraded up to six assemblies of 110 GHz gyrotrons in 2003. three Gycom gyrotrons nominally generate 750 kW for 2 s pulses, with the pulse length limit resulting from the peak temperature allowed on the boron nitride rf output window. Three Communications and Power Industries (CPI) gyrotrons with diamond windows have been recently installed and have been tested to 0.9-1.0 MW for 5 s pulses. Heat loading on internal parts of the gyrotrons, the matching optics unit and the dummy loads is measured calorimetrically. This paper discusses the calorimetry system and calorimetric measurements of gyrotron performance.

  17. Ultra-Responsive Thermal Sensors for the Detection of Explosives Using Calorimetric Spectroscopy (CalSpec)

    SciTech Connect

    Datskos, P.G.; Datskou, I.; Marlar, T.A.; Rajic, S.

    1999-04-05

    We have developed a novel chemical detection technique based on infrared micro-calorimetric spectroscopy that can be used to identify the presence of trace amounts of very low vapor pressure target compounds. Unlike numerous recently developed low-cost sensor approaches, the selectivity is derived from the unique differential temperature spectrum and does not require the questionable reliability of highly selective coatings to achieve the required specificity. This is accomplished by obtaining the infrared micro-calorimetric absorption spectrum of a small number of molecules absorbed on the surface of a thermal detector after illumination through a scanning monochromator. We have obtained infrared micro-calorimetric spectra for explosives such as TNT over the wavelength region 2.5 to 14.5 Mu-m. Thus both sophisticated and relatively crude explosive compounds and components are detectable with these ultra-sensitive thermal-mechanical micro-structures. In addition to the above mentioned spectroscopy technique and associated data, the development of these advanced thermal detectors is also presented in detail.

  18. Nanowell-patterned TiO{sub 2} microcantilevers for calorimetric chemical sensing

    SciTech Connect

    Lee, Dongkyu Chae, Inseok; Thundat, Thomas; Kim, Seonghwan; Jeon, Sangmin

    2014-04-07

    A sensitive calorimetric sensor using a TiO{sub 2} microcantilever with nanowells patterned on one of its sides is described. This single material cantilever is sensitive to temperature change without relying on the metal deposition-based bimetallic effect. The thermomechanical sensitivity originates from the structure dependent variations in both the elastic modulus and thermal expansion coefficient due to the presence of ordered nanowells. These cantilever beams offer an alternate and efficient chemical sensing route for vapor phase analytes using photothermal spectroscopy. Selective and sensitive detection of organophosphorus compounds, as well as their photocatalytic decomposition under ultraviolet light exposure are demonstrated.

  19. Relativistic electron precipitation at International Space Station: Space weather monitoring by Calorimetric Electron Telescope

    NASA Astrophysics Data System (ADS)

    Kataoka, Ryuho; Asaoka, Yoichi; Torii, Shoji; Terasawa, Toshio; Ozawa, Shunsuke; Tamura, Tadahisa; Shimizu, Yuki; Akaike, Yosui; Mori, Masaki

    2016-05-01

    The charge detector (CHD) of the Calorimetric Electron Telescope (CALET) on board the International Space Station (ISS) has a huge geometric factor for detecting MeV electrons and is sensitive to relativistic electron precipitation (REP) events. During the first 4 months, CALET CHD observed REP events mainly at the dusk to midnight sector near the plasmapause, where the trapped radiation belt electrons can be efficiently scattered by electromagnetic ion cyclotron (EMIC) waves. Here we show that interesting 5-20 s periodicity regularly exists during the REP events at ISS, which is useful to diagnose the wave-particle interactions associated with the nonlinear wave growth of EMIC-triggered emissions.

  20. Calorimetric support of directional-hemispherical reflection measurements in the infrared spectral range.

    PubMed

    Richter, W; Sarge, S M; Kämmer, F

    1994-03-01

    Measurements of the directional-hemispherical reflectance ρ with the Physikalisch-Technische Bundesanstalt IR sphere reflectometer have been confirmed by calorimetric determination of the absorptance α in the same geometrical conditions (irradiation at 10°, hemispherical reflection). The good agreement of ρ with (1 - α) on both highly reflecting and low-reflecting surfaces indicates that in the mid-IR spectral range the integrating sphere reflectometer is capable of essentially correct reflectance measurements of diffusely reflecting surfaces, with an estimated uncertainty of 0.01 after correction for a small systematic deviation. This capability opens up the possibility of developing IR reflectance standards. PMID:20862150

  1. Thermodynamic Properties of Liquid Silver-Antimony-Tin Alloys Determined from Electrochemical and Calorimetric Measurements

    NASA Astrophysics Data System (ADS)

    Łapsa, Joanna; Onderka, Bogusław

    2016-05-01

    The thermodynamic properties of liquid Ag-Sb-Sn alloys were obtained through use of the drop solution calorimetric method and electromotive force (emf) measurements of galvanic cells with a yttria stabilized zirconia (YSZ) solid electrolyte. The experiments were carried out along Ag0.25Sb0.75, Ag0.5Sb0.5 and Ag0.75Sb0.25 sections of the ternary system in the temperature range from 973 K to 1223 K. From the measured emf, the tin activity in liquid solutions of Ag-Sb-Sn was determined for the first time. The partial and integral enthalpy of mixing were determined from calorimetric measurements at two temperatures. These measurements were performed along two cross-sections: Sb0.5Sn0.5 at 912 K and 1075 K, and Ag0.75Sb0.25 at 1075 K. Both experimental data sets were used to find ternary interaction parameters by applying the Redlich-Kister-Muggianu model of the substitutional solution. Consequently, the set of parameters describing the thermodynamic properties of the liquid phase was derived.

  2. Kinetics of degradation of diclofenac sodium in aqueous solution determined by a calorimetric method.

    PubMed

    Chadha, R; Kashid, N; Jain, D V S

    2003-09-01

    An isothermal heat conduction microcalorimeter has been used to study the stability of diclofenac sodium both alone and its inclusion complex with beta-cyclodextrin in aqueous solution. The rates of heat evolved during degradation of diclofenac sodium have been measured by a highly sensitive microcalorimetric technique as function of concentration, pH and temperature. The calorimetric accessible data have been incorporated in the equations for determination of rate constants, change in enthalpy and order of reaction. The decomposition of diclofenac sodium both alone and its inclusion complex with beta-cyclodextrin in solution corresponds to a pseudo-first order reaction. The values of rate constants, k's at 338.15 K, (calculated from the variation of heat evolution with the time) for the degradation of diclofenac sodium at pH 5, 6, 7, 8 and its inclusion complex with beta-cyclodextrin at pH 7 are found to be 4.71 x 10(-4), 5.69 x 10(-4), 6.12 x 10(-)4, 6.57 x 10(-4) and 4.26 x 10(-4) h(-1) respectively. There is good agreement between calorimetric determined t(0.5) and literature values. It has been found that beta-cyclodextrin retards the degradation of diclofenac sodium. The kinetic parameters have been calculated for the reaction. The negative entropy of activation suggests the formation of an ordered transition state. PMID:14531458

  3. Calorimetric method of ac loss measurement in a rotating magnetic field.

    PubMed

    Ghoshal, P K; Coombs, T A; Campbell, A M

    2010-07-01

    A method is described for calorimetric ac-loss measurements of high-T(c) superconductors (HTS) at 80 K. It is based on a technique used at 4.2 K for conventional superconducting wires that allows an easy loss measurement in parallel or perpendicular external field orientation. This paper focuses on ac loss measurement setup and calibration in a rotating magnetic field. This experimental setup is to demonstrate measuring loss using a temperature rise method under the influence of a rotating magnetic field. The slight temperature increase of the sample in an ac-field is used as a measure of losses. The aim is to simulate the loss in rotating machines using HTS. This is a unique technique to measure total ac loss in HTS at power frequencies. The sample is mounted on to a cold finger extended from a liquid nitrogen heat exchanger (HEX). The thermal insulation between the HEX and sample is provided by a material of low thermal conductivity, and low eddy current heating sample holder in vacuum vessel. A temperature sensor and noninductive heater have been incorporated in the sample holder allowing a rapid sample change. The main part of the data is obtained in the calorimetric measurement is used for calibration. The focus is on the accuracy and calibrations required to predict the actual ac losses in HTS. This setup has the advantage of being able to measure the total ac loss under the influence of a continuous moving field as experienced by any rotating machines. PMID:20687748

  4. Calorimetric method of ac loss measurement in a rotating magnetic field

    NASA Astrophysics Data System (ADS)

    Ghoshal, P. K.; Coombs, T. A.; Campbell, A. M.

    2010-07-01

    A method is described for calorimetric ac-loss measurements of high-Tc superconductors (HTS) at 80 K. It is based on a technique used at 4.2 K for conventional superconducting wires that allows an easy loss measurement in parallel or perpendicular external field orientation. This paper focuses on ac loss measurement setup and calibration in a rotating magnetic field. This experimental setup is to demonstrate measuring loss using a temperature rise method under the influence of a rotating magnetic field. The slight temperature increase of the sample in an ac-field is used as a measure of losses. The aim is to simulate the loss in rotating machines using HTS. This is a unique technique to measure total ac loss in HTS at power frequencies. The sample is mounted on to a cold finger extended from a liquid nitrogen heat exchanger (HEX). The thermal insulation between the HEX and sample is provided by a material of low thermal conductivity, and low eddy current heating sample holder in vacuum vessel. A temperature sensor and noninductive heater have been incorporated in the sample holder allowing a rapid sample change. The main part of the data is obtained in the calorimetric measurement is used for calibration. The focus is on the accuracy and calibrations required to predict the actual ac losses in HTS. This setup has the advantage of being able to measure the total ac loss under the influence of a continuous moving field as experienced by any rotating machines.

  5. Thermodynamic Properties of Liquid Silver-Antimony-Tin Alloys Determined from Electrochemical and Calorimetric Measurements

    NASA Astrophysics Data System (ADS)

    Łapsa, Joanna; Onderka, Bogusław

    2016-08-01

    The thermodynamic properties of liquid Ag-Sb-Sn alloys were obtained through use of the drop solution calorimetric method and electromotive force (emf) measurements of galvanic cells with a yttria stabilized zirconia (YSZ) solid electrolyte. The experiments were carried out along Ag0.25Sb0.75, Ag0.5Sb0.5 and Ag0.75Sb0.25 sections of the ternary system in the temperature range from 973 K to 1223 K. From the measured emf, the tin activity in liquid solutions of Ag-Sb-Sn was determined for the first time. The partial and integral enthalpy of mixing were determined from calorimetric measurements at two temperatures. These measurements were performed along two cross-sections: Sb0.5Sn0.5 at 912 K and 1075 K, and Ag0.75Sb0.25 at 1075 K. Both experimental data sets were used to find ternary interaction parameters by applying the Redlich-Kister-Muggianu model of the substitutional solution. Consequently, the set of parameters describing the thermodynamic properties of the liquid phase was derived.

  6. Comparison of the calorimetric and kinematic methods of neutrino energy reconstruction in disappearance experiments

    SciTech Connect

    Ankowski, Artur M.; Benhar, Omar; Coloma, Pilar; Huber, Patrick; Jen, Chun -Min; Mariani, Camillo; Meloni, Davide; Vagnoni, Erica

    2015-10-22

    To be able to achieve their physics goals, future neutrino-oscillation experiments will need to reconstruct the neutrino energy with very high accuracy. In this work, we analyze how the energy reconstruction may be affected by realistic detection capabilities, such as energy resolutions, efficiencies, and thresholds. This allows us to estimate how well the detector performance needs to be determined a priori in order to avoid a sizable bias in the measurement of the relevant oscillation parameters. We compare the kinematic and calorimetric methods of energy reconstruction in the context of two νμ → νμ disappearance experiments operating in different energy regimes. For the calorimetric reconstruction method, we find that the detector performance has to be estimated with an O(10%) accuracy to avoid a significant bias in the extracted oscillation parameters. Thus, in the case of kinematic energy reconstruction, we observe that the results exhibit less sensitivity to an overestimation of the detector capabilities.

  7. Calorimetric method of ac loss measurement in a rotating magnetic field

    SciTech Connect

    Ghoshal, P. K.; Coombs, T. A.; Campbell, A. M.

    2010-07-15

    A method is described for calorimetric ac-loss measurements of high-T{sub c} superconductors (HTS) at 80 K. It is based on a technique used at 4.2 K for conventional superconducting wires that allows an easy loss measurement in parallel or perpendicular external field orientation. This paper focuses on ac loss measurement setup and calibration in a rotating magnetic field. This experimental setup is to demonstrate measuring loss using a temperature rise method under the influence of a rotating magnetic field. The slight temperature increase of the sample in an ac-field is used as a measure of losses. The aim is to simulate the loss in rotating machines using HTS. This is a unique technique to measure total ac loss in HTS at power frequencies. The sample is mounted on to a cold finger extended from a liquid nitrogen heat exchanger (HEX). The thermal insulation between the HEX and sample is provided by a material of low thermal conductivity, and low eddy current heating sample holder in vacuum vessel. A temperature sensor and noninductive heater have been incorporated in the sample holder allowing a rapid sample change. The main part of the data is obtained in the calorimetric measurement is used for calibration. The focus is on the accuracy and calibrations required to predict the actual ac losses in HTS. This setup has the advantage of being able to measure the total ac loss under the influence of a continuous moving field as experienced by any rotating machines.

  8. Comparison of the calorimetric and kinematic methods of neutrino energy reconstruction in disappearance experiments

    DOE PAGESBeta

    Ankowski, Artur M.; Benhar, Omar; Coloma, Pilar; Huber, Patrick; Jen, Chun -Min; Mariani, Camillo; Meloni, Davide; Vagnoni, Erica

    2015-10-22

    To be able to achieve their physics goals, future neutrino-oscillation experiments will need to reconstruct the neutrino energy with very high accuracy. In this work, we analyze how the energy reconstruction may be affected by realistic detection capabilities, such as energy resolutions, efficiencies, and thresholds. This allows us to estimate how well the detector performance needs to be determined a priori in order to avoid a sizable bias in the measurement of the relevant oscillation parameters. We compare the kinematic and calorimetric methods of energy reconstruction in the context of two νμ → νμ disappearance experiments operating in different energymore » regimes. For the calorimetric reconstruction method, we find that the detector performance has to be estimated with an O(10%) accuracy to avoid a significant bias in the extracted oscillation parameters. Thus, in the case of kinematic energy reconstruction, we observe that the results exhibit less sensitivity to an overestimation of the detector capabilities.« less

  9. Calorimetric Thermoelectric Gas Sensor for the Detection of Hydrogen, Methane and Mixed Gases

    PubMed Central

    Park, Nam-Hee; Akamatsu, Takafumi; Itoh, Toshio; Izu, Noriya; Shin, Woosuck

    2014-01-01

    A novel miniaturized calorimeter-type sensor device with a dual-catalyst structure was fabricated by integrating different catalysts on the hot (Pd/θ-Al2O3) and cold (Pt/α-Al2O3) ends of the device. The device comprises a calorimeter with a thermoelectric gas sensor (calorimetric-TGS), combining catalytic combustion and thermoelectric technologies. Its response for a model fuel gas of hydrogen and methane was investigated with various combustor catalyst compositions. The calorimetric-TGS devices detected H2, CH4, and a mixture of the two with concentrations ranging between 200 and 2000 ppm at temperatures of 100–400 °C, in terms of the calorie content of the gases. It was necessary to reduce the much higher response voltage of the TGS to H2 compared to CH4. We enhanced the H2 combustion on the cold side so that the temperature differences and response voltages to H2 were reduced. The device response to H2 combustion was reduced by 50% by controlling the Pt concentration in the Pt/α-Al2O3 catalyst on the cold side to 3 wt%. PMID:24818660

  10. Stabilization of Cu(I) for binding and calorimetric measurements in aqueous solution†

    PubMed Central

    Johnson, Destinee K.; Stevenson, Michael J.; Almadidy, Zayed A.; Jenkins, Sharon E.; Wilcox, Dean. E.; Grossoehme, Nicholas E.

    2015-01-01

    Conditions have been developed for the comproportionation reaction of Cu2+ and copper metal to prepare aqueous solutions of Cu+ that are stabilized from disproportionation by MeCN and other Cu+-stabilizing ligands. These solutions were then used in ITC measurements to quantify the thermodynamics of formation of a set of Cu+ complexes (CuI(MeCN)3+, CuIMe6Trien+, CuI(BCA)23−, CuI(BCS)23−), which have stabilities ranging over 15 orders of magnitude, for their use in binding and calorimetric measurements of Cu+ interaction with proteins and other biological macromolecules. These complexes were then used to determine the stability and thermodynamics of formation of a 1 : 1 complex of Cu+ with the biologically important tri-peptide glutathione, GSH. These results identify Me6Trien as an attractive Cu+-stabilizing ligand for calorimetric experiments, and suggest that caution should be used with MeCN to stabilize Cu+ due to its potential for participating in unquantifiable ternary interactions. PMID:26327397

  11. Thermodynamic properties by non-calorimetric methods. Progress report, August 1, 1988--July 31, 1989

    SciTech Connect

    Steele, W.V.; Chirico, R.D.; Collier, W.B.; Strube, M.M. |

    1989-12-31

    This three year research program provides a valuable complement to the experimental programs currently in progress at NIPER for the Advanced Research and Technology Development (AR and TD) and Advanced Exploration and Process Technology (AEPT) divisions of the Department of Energy. These experimental programs are focused on the calorimetric determination of thermodynamic properties of key polynuclear heteroatom-containing aromatic molecules. This project for the Office of Energy Research focuses on the non-calorimetric determination of thermodynamic properties through the extension of existing correlation methodologies and through molecular spectroscopy with statistical mechanics. The paper discusses progress in three areas: (1) Improvement of thermochemical and thermophysical property predictions via enhancement of group-contribution methods using two approaches, namely, development and improvement of group-contribution parameters via correlations involving the expanded modern thermodynamics data base and development of group-contribution parameters via molecular spectroscopy and statistical mechanics of key monocyclic organic compounds; (2) Molecular spectroscopy and statistical mechanics: equipment development and developments in interpretation and assignment of spectra; and (3) Thermophysical property correlations.

  12. Le Indeterminacy in Spanish.

    ERIC Educational Resources Information Center

    Foster, David William

    The standard treatment of object pronouns in Latin American Spanish assigns a direct-object function to "lo" and "la" and an indirect-object function to "le." This study challenges this descriptive attribution in light of the contradictory and refractory evidence in Spanish morphosyntax. It is suggested that more detailed research, especially…

  13. Le Figaro. Revised.

    ERIC Educational Resources Information Center

    Crawford, Linda

    These instructional materials are designed for students with some French reading skills and vocabulary in late beginning or early intermediate senior high school French. The objectives are to introduce students to a French newspaper, "Le Figaro," and develop reading skills for skimming, gathering specific information, and relying on cognates. The…

  14. ESTIMATION OF BARE-SOIL EVAPORATION USING A CALORIMETRIC APPROACH WITH HEAT FLUX MEASURED AT MULTIPLE DEPTHS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    An assumption in calorimetric methods for soil heat flux is that sensible heat terms can be balanced (i.e., if the heat flux is known at one depth, the heat flux at another depth may be determined by monitoring the change in heat storage). Latent heat from water evaporation is assigned to the energy...

  15. Emittance characterization of thermal control paints, coatings and surfaces using a calorimetric technique

    NASA Technical Reports Server (NTRS)

    Jaworske, Donald A.

    1994-01-01

    Thermal control surfaces are used in every spacecraft thermal management system to dissipate heat through radiant heat transfer. This paper describes the thermal performance of several thermal control paints, coatings, and surfaces, as characterized by a calorimetric vacuum emissometer. The emissometer is designed to measure the functional emittance of a surface based on heat transfer from an underlying substrate to the surface and from the surface or near surface to a surrounding cold wall. Emittance measurements were made between 200 and 350 K. Polished aluminum, used here as a standard, was found to have a total hemispherical emittance of 0.06, as expected. A velvet black paint, also used here as a standard, was found to have an emittance of 0.94 at room temperature. Other surfaces of interest included a polyurethane-based black paint designated Z-306, a highly polished 316L stainless steel, and an atomic oxygen beam-textured carbon-carbon composite.

  16. Molecular mobility and relaxation process of isolated lignin studied by multifrequency calorimetric experiments.

    PubMed

    Guigo, Nathanael; Mija, Alice; Vincent, Luc; Sbirrazzuoli, Nicolas

    2009-02-28

    The glass transition of lignin has been studied by multifrequency calorimetric measurements in order to highlight the morphological changes and the dynamic aspects associated to this relaxation process. Influences of water sorption and thermal annealing on molecular mobility have been considered. Additional investigations by thermogravimetry, infra-red spectroscopy and rheometry have been performed to corroborate the claims. The relaxation process of annealed lignin shows a different behaviour as the consequence of micro-structural modifications of lignin. These are explained by redistribution of secondary bonds as well as formation of new interunit linkages. Concerning the dynamic aspects, apparent activation energy, E, and sizes of cooperatively rearranging region, V(crr), have been evaluated respectively from the frequency dependence and heat capacity measurements of the glass transition. Compared to dried lignin, both E and V(crr) significantly decrease in a water-sorbed matrix indicating that the three-dimensional structure presents a higher mobility and is less confined. PMID:19209367

  17. Biodegradable composites filled with halloysite nanonotubes: Calorimetric investigations and structural issues

    NASA Astrophysics Data System (ADS)

    Russo, Pietro; Vetrano, Barbara; Acierno, Domenico

    2012-07-01

    Halloysite nanotubes were dispersed in a commercially biodegradable blends by melt compounding. Bionanocomposites based on a film-grade commercial blend of poly(hydroxybutirate)-co-valerate PHBV and poly(butylene adipate-co-therephthalate) PBAT and containg up to 10% by weigth of tubular clays (HNTs) were prepared by using a twin-screw lab extruder and filmed by a film-blowing equipment. Film samples were subjected to thermal and structural investigations. Calorimetric analysis showed that signals shape is clearly affected by the heating and cooling rate, respectively. Structural investigations performed by X-Ray diffraction tests satisfactorily allowed to interpret thermal behavior highlighting the occurrence of different crystalline modifications, depending on the scanning thermal rate, the inclusion of filler and its chemical functionalization.

  18. A calorimetric study on interactions of colchicine with human serum albumin

    NASA Astrophysics Data System (ADS)

    Zhao, Qiang; Xu, Xiang-Yu; Sun, Xiang-Jun; Liu, Min; Sun, De-Zhi; Li, Lin-Wei

    2009-08-01

    Interaction of colchicine (COL) with human serum albumin (HSA) in buffer solutions (pH 7.2) has been investigated by isothermal titration calorimetry (ITC) combined with circular dichroism (CD) and UV-vis spectra. Heats of the interactions have been determined at 298.15 K. Based on the calorimetric data and reasonable suppositions for the bio-macromolecule - ligand binding process, the equilibrium constants, standard changes of enthalpy, entropy and Gibbs free energy of the processes are obtained. The results show that there are two classes of ligand binding sites. The first-class binding is mainly driven by entropy, while the second-class binding is synergistically driven by entropy and enthalpy. Circular dichroism (CD) and UV-vis spectra show that COL can change the secondary structure of HSA molecule.

  19. Calorimetric study on the effect of 60Co γ-rays on the growth of microorganisms

    NASA Astrophysics Data System (ADS)

    Wirkner, Sandra; Takahashi, Katsutada; Furuta, Masakazu; Hayashi, Toshio

    2002-03-01

    Using a calorimeter equipped with 24 sample units, the heat evolution from growing Saccharomyces cerevisiae, Escherichia coli and spores of Bacillus pumilus and Bacillus stearothermophilus was detected in the form of growth thermograms. Irradiation with 60Co γ-rays affected the growth pattern, which was used for a quantitative analysis of the effect on microorganisms. Irradiation of B. pumilus and B. stearothermophilus spores led to dose-dependent delays in growth, indicating a bactericidal effect. In case of 60Co γ-irradiated S. cerevisiae, a dose-dependent reduction of the growth rate constant was observed together with the retardation in growth, indicating a combination of bactericidal and bacteriostatic effects. An equation to determine the number of survivors on the basis of the retardation in growth tα and the growth rate constant μ was developed, which proved the opportunity to use the calorimetric technique in predictive microbiology.

  20. AC loss measurement of superconducting dipole magnets by the calorimetric method

    SciTech Connect

    Morita, Y.; Hara, K.; Higashi, N.; Kabe, A.

    1996-12-31

    AC losses of superconducting dipole magnets were measured by the calorimetric method. The magnets were model dipole magnets designed for the SSC. These were fabricated at KEK with 50-mm aperture and 1.3-m overall length. The magnet was set in a helium cryostat and cooled down to 1.8 K with 130 L of pressurized superfluid helium. Heat dissipated by the magnet during ramp cycles was measured by temperature rise of the superfluid helium. Heat leakage into the helium cryostat was 1.6 W and was subtracted from the measured heat to obtain AC loss of the magnet. An electrical measurement was carried out for calibration. Results of the two methods agreed within the experimental accuracy. The authors present the helium cryostat and measurement system in detail, and discuss the results of AC loss measurement.

  1. Total hemispherical emittance measured at high temperatures by the calorimetric method

    NASA Technical Reports Server (NTRS)

    Difilippo, Frank; Mirtich, Michael J.; Banks, Bruce A.; Stidham, Curtis; Kussmaul, Michael

    1989-01-01

    A calorimetric vacuum emissometer (CVE) capable of measuring total hemispherical emittance of surfaces at elevated temperatures was designed, built, and tested. Several materials with a wide range of emittances were measured in the CVE between 773 to 923 K. These results were compared to values calculated from spectral emittance curves measured in a room temperature Hohlraum reflectometer and in an open-air elevated temperature emissometer. The results differed by as much as 0.2 for some materials but were in closer agreement for the more highly-emitting, diffuse-reflecting samples. The differences were attributed to temperature, atmospheric, and directional effects, and errors in the Hohlraum and emissometer measurements (plus or minus 5 percent). The probable error of the CVE measurements was typically less than 1 percent.

  2. Calorimetric determination of thermal parameters for the Li/BrCl in SOCl2 (BCX) chemistry

    NASA Technical Reports Server (NTRS)

    Darcy, Eric C.; Kalu, Eric E.; White, Ralph E.

    1990-01-01

    The heat capacity of a Li-BCX DD-cell was found to be dependent on its state of charge by drop calorimetry measurements. The method of drop calorimetry involves measuring the energy (joules) gained or lost from a sample that is transferred from a bath at temperature A to one at temperature B. The thermoneutral potential is defined as the cell potential where the cell electrochemical reactions are neither exothermic nor endothermic. A Hart scientific calorimeter system, Model No. S77XX, designed for heat conduction calorimetry and drop calorimetry was used. Calorimetric analysis yielded a thermoneutral potential of 4.14 volts and a cell heat capacity dependent on the state of charge.

  3. Direct calorimetric verification of thermodynamic instability of lead halide hybrid perovskites.

    PubMed

    Nagabhushana, G P; Shivaramaiah, Radha; Navrotsky, Alexandra

    2016-07-12

    Hybrid perovskites, especially methylammonium lead iodide (MAPbI3), exhibit excellent solar power conversion efficiencies. However, their application is plagued by poor chemical and structural stability. Using direct calorimetric measurement of heats of formation, MAPbI3 is shown to be thermodynamically unstable with respect to decomposition to lead iodide and methylammonium iodide, even in the absence of ambient air or light or heat-induced defects, thus limiting its long-term use in devices. The formation enthalpy from binary halide components becomes less favorable in the order MAPbCl3, MAPbBr3, MAPbI3, with only the chloride having a negative heat of formation. Optimizing the geometric match of constituents as measured by the Goldschmidt tolerance factor provides a potentially quantifiable thermodynamic guide for seeking chemical substitutions to enhance stability. PMID:27357677

  4. Total hemispherical emittance measured at high temperatures by the calorimetric method

    SciTech Connect

    DiFilippo, F.; Mirtich, M.J.; Banks, B.A.; Stidham, C.; Kussmaul, M.

    1994-09-01

    A calorimetric vacuum emissometer (CVE) capable of measuring total hemispherical emittance of surfaces at elevated temperatures was designed, built, and tested. Several materials with a wide range of emittances were measured in the CVE between 773 to 923 K. These results were compared to values calculated from spectral emittance curves measured in a room temperature Hohlraum reflectometer and in an open-air elevated temperature emissometer. The results differed by as much as 0.2 for some materials but were in closer agreement for the more highly-emitting, diffuse-reflecting samples. The differences were attributed to temperature, atmospheric, and directional effects, and errors in the Hohlraum and emissometer measurements ({+-} 5 percent). The probable error of the CVE measurements was typically less than 1 percent.

  5. Calorimetric approach for 3D dosimetry of high intensity therapeutic electron beams

    NASA Astrophysics Data System (ADS)

    Lamanna, E.; Fiorillo, A. S.; Vena, R.; Berdondini, A.; Bettuzzi, M.; Brancaccio, R.; Casali, F.; Morigi, M. P.; Bilokon, H.; Barca, G.; Castrovillari, F.; Siaka, Y. F. T.

    2009-12-01

    The technique of High Dose Rate Intra-Operative Radiation Therapy (HDR-IORT) consists in the delivery of irradiation immediately after the removal of a cancerous mass, where the same incision is used to focalize the radiation to the tumour bed. Given its particular characteristics, IORT requires dose measurements that are different from those requested in external radiotherapy treatments. The main reason lies in the fact that in this case a single high dose must be delivered to a target volume whose extension and depth will be determined directly during the operation. Because of this peculiar characteristics, until now there is not a dosimetric system able to detect the electron beam giving at once a realtime response and an extensive spatial measure of the absorbed dose. Within the framework of a research project of the INFN (Italian National Institute of Nuclear Physics), we proposed a new system to overcome the problems, Dosiort. The final set-up is a solid phantom having a density approximately 1 g/cm3 with sensitive layers of scintillating fibres at fixed positions in a calorimetric configuration for the containment of electrons of energy 4-12 MeV. The prototype will be able to define the physical and geometrical characteristics of the electron beam (energy, isotropy, homogeneity, etc) and to measure the parameters needed to select the energy, the intensity and the Monitor Units (MU) for the exposition: percentage Depth Dose; beam profiles; isodose curves; values of dose per MU. In this work we present the results obtained by using two orthogonal layers of the calorimetric phantom Dosiort, in particular we report the measurement of the dynamic range of the read-out system and the first qualitative study of the results which can be extracted from the measurements taken in a test beam.

  6. Le mouvement du pôle

    NASA Astrophysics Data System (ADS)

    Bizouard, Christian

    2012-03-01

    Les variations de la rotation terrestre. En conditionnant à la fois notre vie quotidienne, notre perception du ciel, et bon nombre de phénomènes géophysiques comme la formation des cyclones, la rotation de la Terre se trouve au croisement de plusieurs disciplines. Si le phenomena se faisait uniformément, le sujet serait vite discuté, mais c'est parce que la rotation terrestre varie, même imperceptiblement pour nos sens, dans sa vitesse angulaire comme dans la direction de son axe, qu'elle suscite un grand intérêt. D'abord pour des raisons pratiques : non seulement les aléas de la rotation terrestre modi_ent à la longue les pointés astrométriques à un instant donné de la journée mais in_uencent aussi les mesures opérées par les techniques spatiales ; en consequence l'exploitation de ces mesures, par exemple pour déterminer les orbites des satellites impliqués ou pratiquer le positionnement au sol, nécessite une connaissance précise de ces variations. Plus fondamentalement, elles traduisent les propriétés globales de la Terre comme les processus physiques qui s'y déroulent, si bien qu'en analysant les causes des fluctuations observées, on dispose d'un moyen de mieux connaître notre globe. La découverte progressive des fluctuations de la rotation de la Terre a une longue histoire. Sous l'angle des techniques d'observation, trois époques se pro-celle du pointé astrométrique à l'oeil nu, à l'aide d'instruments en bois ou métalliques (quart de cercle muraux par exemple). À partir du XVIIe siècle débute l'astrométrie télescopique dont les pointés sont complétés par des datations de plus en plus précises grâce à l'invention d'horloges régulées par balancier. Cette deuxième époque se termine vers 1960, avec l'avènement des techniques spatiales : les pointés astrométriques sont délaissés au profit de la mesure ultra-précise de durées ou de fréquences de signaux électromagnétiques, grâce à l'invention des horloges

  7. Calorimetric output power measurements on a CW 20 kW 7.16 GHz microwave transmitter

    NASA Technical Reports Server (NTRS)

    Perez, Raul M.; Conroy, Bruce L.

    1991-01-01

    A calorimetric measurement technique developed for NASA's Deep Space Network (DSN) transmitters that does not require data on the coolant's thermal parameters is described. Calibration of the measurement system is achieved by measuring the DC input power to the klystron and relating coolant temperature increases to this known power dissipation. Agreement between calorimetric and electrical measurements of total system power was good, the difference being less than 2 percent. The operation of the system was not greatly affected by the composition of the coolant, which was varied from pure water to 40 percent ethylene glycol by mass. Good accuracy was also shown at output power levels, which varied over a 3.6:1 range.

  8. Differential scanning calorimetric evaluation of human meibomian gland secretions and model lipid mixtures: transition temperatures and cooperativity of melting

    PubMed Central

    Lu, Hua; Wojtowicz, Jadwiga C.; Butovich, Igor A.

    2013-01-01

    Meibomian gland secretions (or meibum) are produced by holocrine meibomian glands and are secreted in melted form onto the ocular surface of humans and animals to form a protective tear film lipid layer (TFLL). Its protective effect strongly depends on the composition and, hence, thermotropic behavior of meibum. The goal of our study was to quantitatively evaluate the melting characteristics of human meibum and model lipid mixtures using differential scanning microcalorimetry. Standard calorimetric parameters, e.g. changes in calorimetric enthalpy, transition temperatures T(m), cooperativity of melting etc. were assessed. We found that thermotropic behavior of meibum resembled that of relatively simple mixtures of unsaturated wax esters, but showed a lower change in calorimetric enthalpy, which can be indicative of a looser packing of lipids in meibum compared with pure standards and their simple mixtures. The cooperativity of melting of meibomian lipids was comparable to that of an equimolar mixture of four oleic-acid based wax esters. We demonstrated that the phase transitions in meibum start at about 10 to 15 °C and end at 35-36 °C, with T(m) being about 30 °C. The highly asymmetrical shape of the thermotropic peak of meibum is important for the physiology and biophysics of TFLL. PMID:23578711

  9. Electron energy and charge albedos - calorimetric measurement vs Monte Carlo theory

    SciTech Connect

    Lockwood, G.J.; Ruggles, L.E.; Miller, G.H.; Halbleib, J.A.

    1981-11-01

    A new calorimetric method has been employed to obtain saturated electron energy albedos for Be, C, Al, Ti, Mo, Ta, U, and UO/sub 2/ over the range of incident energies from 0.1 to 1.0 MeV. The technique was so designed to permit the simultaneous measurement of saturated charge albedos. In the cases of C, Al, Ta, and U the measurements were extended down to about 0.025 MeV. The angle of incidence was varied from 0/sup 0/ (normal) to 75/sup 0/ in steps of 15/sup 0/, with selected measurements at 82.5/sup 0/ in Be and C. In each case, state-of-the-art predictions were obtained from a Monte Carlo model. The generally good agreement between theory and experiment over this extensive parameter space represents a strong validation of both the theoretical model and the new experimental method. Nevertheless, certain discrepancies at low incident energies, especially in high-atomic-number materials, and at all energies in the case of the U energy albedos are not completely understood.

  10. Algorithms for Identification of Nearly-Coincident Events in Calorimetric Sensors

    NASA Astrophysics Data System (ADS)

    Alpert, B.; Ferri, E.; Bennett, D.; Faverzani, M.; Fowler, J.; Giachero, A.; Hays-Wehle, J.; Maino, M.; Nucciotti, A.; Puiu, A.; Swetz, D.; Ullom, J.

    2015-12-01

    For experiments with high arrival rates, reliable identification of nearly-coincident events can be crucial. For calorimetric measurements to directly measure the neutrino mass such as HOLMES, unidentified pulse pile-ups are expected to be a leading source of experimental error. Although Wiener filtering can be used to recognize pile-up, it suffers from errors due to pulse shape variation from detector nonlinearity, readout dependence on subsample arrival times, and stability issues from the ill-posed deconvolution problem of recovering Dirac delta-functions from smooth data. Due to these factors, we have developed a processing method that exploits singular value decomposition to (1) separate single-pulse records from piled-up records in training data and (2) construct a model of single-pulse records that accounts for varying pulse shape with amplitude, arrival time, and baseline level, suitable for detecting nearly-coincident events. We show that the resulting processing advances can reduce the required performance specifications of the detectors and readout system or, equivalently, enable larger sensor arrays and better constraints on the neutrino mass.

  11. The CALorimetric Electron Telescope (CALET) for high-energy astroparticle physics on the International Space Station

    NASA Astrophysics Data System (ADS)

    Adriani, O.; Akaike, Y.; Asano, K.; Asaoka, Y.; Bagliesi, M. G.; Bigongiari, G.; Binns, W. R.; Bonechi, S.; Bongi, M.; Buckley, J. H.; Castellini, G.; Cherry, M. L.; Collazuol, G.; Ebisawa, K.; Di Felice, V.; Fuke, H.; Guzik, T. G.; Hams, T.; Hareyama, M.; Hasebe, N.; Hibino, K.; Ichimura, M.; Ioka, K.; Israel, M. H.; Javaid, A.; Kamioka, E.; Kasahara, K.; Kataoka, J.; Kataoka, R.; Katayose, Y.; Kawanaka, N.; Kitamura, H.; Kotani, T.; Krawczynski, H. S.; Krizmanic, J. F.; Kubota, A.; Kuramata, S.; Lomtadze, T.; Maestro, P.; Marcelli, L.; Marrocchesi, P. S.; Mitchell, J. W.; Miyake, S.; Mizutani, K.; Moiseev, A. A.; Mori, K.; Mori, M.; Mori, N.; Motz, H. M.; Munakata, K.; Murakami, H.; Nakagawa, Y. E.; Nakahira, S.; Nishimura, J.; Okuno, S.; Ormes, J. F.; Ozawa, S.; Palma, F.; Papini, P.; Rauch, B. F.; Ricciarini, S. B.; Sakamoto, T.; Sasaki, M.; Shibata, M.; Shimizu, Y.; Shiomi, A.; Sparvoli, R.; Spillantini, P.; Takahashi, I.; Takayanagi, M.; Takita, M.; Tamura, T.; Tateyama, N.; Terasawa, T.; Tomida, H.; Torii, S.; Tunesada, Y.; Uchihori, Y.; Ueno, S.; Vannuccini, E.; Wefel, J. P.; Yamaoka, K.; Yanagita, S.; Yoshida, A.; Yoshida, K.; Yuda, T.

    2015-08-01

    The CALorimetric Electron Telescope (CALET) is a space experiment, currently under development by Japan in collaboration with Italy and the United States, which will measure the flux of cosmic-ray electrons (and positrons) up to 20 TeV energy, of gamma rays up to 10 TeV, of nuclei with Z from 1 to 40 up to 1 PeV energy, and will detect gamma-ray bursts in the 7 keV to 20 MeV energy range during a 5 year mission. These measurements are essential to investigate possible nearby astrophysical sources of high energy electrons, study the details of galactic particle propagation and search for dark matter signatures. The main detector of CALET, the Calorimeter, consists of a module to identify the particle charge, followed by a thin imaging calorimeter (3 radiation lengths) with tungsten plates interleaving scintillating fibre planes, and a thick energy measuring calorimeter (27 radiation lengths) composed of lead tungstate logs. The Calorimeter has the depth, imaging capabilities and energy resolution necessary for excellent separation between hadrons, electrons and gamma rays. The instrument is currently being prepared for launch (expected in 2015) to the International Space Station ISS, for installation on the Japanese Experiment Module - Exposure Facility (JEM-EF).

  12. The CALorimetric Electron Telescope (CALET) for high-energy astroparticle physics on the International Space Station

    NASA Astrophysics Data System (ADS)

    Adriani, O.; Akaike, Y.; Asano, K.; Asaoka, Y.; Bagliesi, M. G.; Bigongiari, G.; Binns, W. R.; Bonechi, S.; Bongi, M.; Buckley, J. H.; Castellini, G.; Cherry, M. L.; Collazuol, G.; Ebisawa, K.; Di Felice, V.; Fuke, H.; Guzik, T. G.; Hams, T.; Hareyama, M.; Hasebe, N.; Hibino, K.; Ichimura, M.; Ioka, K.; Israel, M. H.; Javaid, A.; Kamioka, E.; Kasahara, K.; Kataoka, J.; Kataoka, R.; Katayose, Y.; Kawanaka, N.; Kitamura, H.; Kotani, T.; Krawczynski, H. S.; Krizmanic, J. F.; Kubota, A.; Kuramata, S.; Lomtadze, T.; Maestro, P.; Marcelli, L.; Marrocchesi, P. S.; Mitchell, J. W.; Miyake, S.; Mizutani, K.; Moiseev, A. A.; Mori, K.; Mori, M.; Mori, N.; Motz, H. M.; Munakata, K.; Murakami, H.; Nakagawa, Y. E.; Nakahira, S.; Nishimura, J.; Okuno, S.; Ormes, J. F.; Ozawa, S.; Palma, F.; Papini, P.; Rauch, B. F.; Ricciarini, S. B.; Sakamoto, T.; Sasaki, M.; Shibata, M.; Shimizu, Y.; Shiomi, A.; Sparvoli, R.; Spillantini, P.; Takahashi, I.; Takayanagi, M.; Takita, M.; Tamura, T.; Tateyama, N.; Terasawa, T.; Tomida, H.; Torii, S.; Tunesada, Y.; Uchihori, Y.; Ueno, S.; Vannuccini, E.; Wefel, J. P.; Yamaoka, K.; Yanagita, S.; Yoshida, A.; Yoshida, K.; Yuda, T.

    2015-05-01

    The CALorimetric Electron Telescope (CALET) is a space experiment, currently under development by Japan in collaboration with Italy and the United States, which will measure the flux of cosmic-ray electrons (and positrons) up to 20 TeV energy, of gamma rays up to 10 TeV, of nuclei with Z from 1 to 40 up to 1 PeV energy, and will detect gamma-ray bursts in the 7 keV to 20 MeV energy range during a 5 year mission. These measurements are essential to investigate possible nearby astrophysical sources of high energy electrons, study the details of galactic particle propagation and search for dark matter signatures. The main detector of CALET, the Calorimeter, consists of a module to identify the particle charge, followed by a thin imaging calorimeter (3 radiation lengths) with tungsten plates interleaving scintillating fibre planes, and a thick energy measuring calorimeter (27 radiation lengths) composed of lead tungstate logs. The Calorimeter has the depth, imaging capabilities and energy resolution necessary for excellent separation between hadrons, electrons and gamma rays. The instrument is currently being prepared for launch (expected in 2015) to the International Space Station ISS, for installation on the Japanese Experiment Module - Exposure Facility (JEM-EF).

  13. Calorimetric method for adjusting the mass of culture fluid in a bioreactor

    NASA Astrophysics Data System (ADS)

    Kotelnikov, G. V.; Moiseyeva, S. P.; Krayev, V. P.

    1998-05-01

    A new calorimetric method for adjusting the mass of culture fluid in a bioreactor and the results of its experimental testing are described. The method is based on constant heat capacity of liquids in the presence of disturbing factors accompanying biotechnology processes. A new measuring parameter independent of thermal noise induced by the stirrer, the flow of fluids, chemical and physical interactions of substances in the bioreactor was used for adjusting the mass of culture fluid. This parameter is Ph, the power increment in the heater under steady-state conditions of heating the bioreactor. The scanning calorimetry principle was used to make the measurements. It was shown that it is necessary to provide a constant heating rate V for the bioreactor and a high-speed response of the automated control system (ACS) for bioreactor temperature. The ACS developed on the base of the dynamic error and transient response h(t) calculated by the inverse Laplace transform with the use of the closed-loop transfer function gives V=const and the control time of about several seconds. The experimental data reported show the adjustment of the mass of culture fluid in a 3 l bioreactor with an error of no more than 10 g. This enables an accurate evaluation of the biomass amount in the bioreactor, specific growth rate, and other growth parameters determined using specific growth rate.

  14. First calorimetric determination of heat of extraction of 248Cm in a bi-phasic system

    SciTech Connect

    Leigh R. Martin; Peter R. Zalupski

    2011-06-01

    This report presents a summary of the work performed to meet FCR&D level 2 milestone M21SW050201, 'Complete the first calorimetric determination of heat of extraction of 248Cm in a bi-phasic system'. This work was carried out under the auspices of the Thermodynamics and Kinetics FCR&D work package. To complement previous work undertaken under this work package we have extended out heat of extraction studies by di-2-ethyl-hexyl-phosphoric acid to curium. This report also details the heat of extraction of samarium in the same system. This work was performed to not only test the methodology but also to check for consistency with the heats of extraction obtained with those in the prior literature. The heat of extraction for samarium that was obtained in this study was -9.6 kJ mol-1, which is in reasonable agreement with the previously obtained value of -10.9 kJ mol-1. The curium heat of extraction was performed under two sets of conditions and the obtained heats of extraction were in reasonable agreement with each other at -16.0 {+-} 1.1 and -16.8 {+-} 1.5 kJ mol-1.

  15. A calorimetric study of the hydrolysis and peroxide complex formation of the uranyl(VI) ion.

    PubMed

    Zanonato, Pier Luigi; Di Bernardo, Plinio; Grenthe, Ingmar

    2014-02-14

    The enthalpies of reaction for the formation of uranyl(vi) hydroxide {[(UO2)2(OH)2](2+), [(UO2)3(OH)4](2+), [(UO2)3(OH)5](+), [(UO2)3(OH)6](aq), [(UO2)3(OH)7](-), [(UO2)3(OH)8](2-), [(UO2)(OH)3](-), [(UO2)(OH)4](2-)} and peroxide complexes {[UO2(O2)(OH)](-) and [(UO2)2(O2)2(OH)](-)} have been determined from calorimetric titrations at 25 °C in a 0.100 M tetramethyl ammonium nitrate ionic medium. The hydroxide data have been used to test the consistency of the extensive thermodynamic database published by the Nuclear Energy Agency (I. Grenthe, J. Fuger, R. J. M. Konings, R. J. Lemire, A. B. Mueller, C. Nguyen-Trung and H. Wanner, Chemical Thermodynamics of Uranium, North-Holland, Amsterdam, 1992 and R. Guillaumont, T. Fanghänel, J. Fuger, I. Grenthe, V. Neck, D. J. Palmer and M. R. Rand, Update on the Chemical Thermodynamics of Uranium, Neptunium, Plutonium, Americium and Technetium, Elsevier, Amsterdam, 2003). A brief discussion is given about a possible structural relationship between the trinuclear complexes [(UO2)3(OH)n](6-n), n = 4-8. PMID:24301256

  16. Optical and Calorimetric Studies of Cholesterol-Rich Filamentous, Helical Ribbon and Crystal Microstructures

    SciTech Connect

    Miroshnikova, Y. A.; Elsenbeck, M.; Zastavker, Y. V.; Kashuri, K; Iannacchione, G. S.

    2009-04-19

    Formation of biological self-assemblies at all scales is a focus of studies in fields ranging from biology to physics to biomimetics. Understanding the physico-chemical properties of these self-assemblies may lead to the design of bio-inspired structures and technological applications. Here we examine self-assembled filamentous, helical ribbon, and crystal microstructures formed in chemically defined lipid concentrate (CDLC), a model system for cholesterol crystallization in gallbladder bile. CDLC consists of cholesterol, bilayer-forming amphiphiles, micelle-forming amphiphiles, and water. Phase contrast and differential interference contrast (DIC) microscopy indicate the presence of three microstructure types in all samples studied, and allow for an investigation of the structures' unique geometries. Additionally, confocal microscopy is used for qualitative assessment of surface and internal composition. To complement optical observations, calorimetric (differential-scanning and modulation) experiments, provide the basis for an in-depth understanding of collective and individual thermal behavior. Observed ''transition'' features indicate clustering and ''straightening'' of helical ribbons into short, increasingly thickening, filaments that dissolve with increasing temperature. These results suggest that all microstructures formed in CDLC may coexist in a metastable chemical equilibrium. Further investigation of the CDLC thermal profile should uncover the process of cholesterol crystallization as well as the unique design and function of microstructures formed in this system.

  17. Calorimetric studies of the ammonia-water system with application to the outer solar system

    NASA Astrophysics Data System (ADS)

    Yarger, J.; Lunine, J. I.; Burke, M.

    1993-07-01

    A series of heating experiments was performed on the condensed ammonia-water system using a differential scanning calorimeter (DSC). The water-rich samples were cooled quickly to below 130 K, then heated at a variety of rates. Rather than a single peritectic melt at 176 K, expected for the equilibrium system of water ice and ammonia dihydrate, four enthalpic transitions were repeatedly seen in the temperature range 150-176 K. These transitions are generally consistent with the earlier calorimetric results of Van Kasteren (1973), who interpreted the lowest temperature exotherm as crystallization of an amorphous ammonia-water compound formed during cooling. We propose that both sets of experiments are seeing the crystallization of ammonia monohydrate, which is metastable relative to the dihydrate, followed by partial remelting and crystallization of dihydrate upon further heating. The apparent stability of the monohydrate in the dihydrate equilibrium field implies a potentially complex behavior of ammonia-water ices in satellites. Possible self-heating of the mixture by several tens of degrees up to the 170 K eutectic could make mobilization of ammonia-water liquids in icy satellite interiors energetically easier than previously thought.

  18. Calorimetric measurement of electron energy deposition in extended media. Theory vs experiment

    SciTech Connect

    Lockwood, G.J.; Ruggles, L.E.; Miller, G.H.; Halbleib, J.A.

    1980-01-01

    A new calorimetric technique has been developed for measuring electron energy deposition profiles in one dimension. The experimental procedures and theoretical analyses required in the application of the new method are reviewed. Extensive results are presented for electron energy deposition profiles in semi-infinite homogeneous and multilayer configurations. These data cover a range of elements from beryllium through uranium at source energies from 0.3 to 1.0 MeV (selected data at 0.5 and 0.1 MeV) and at incident angles from 0/sup 0/ to 60/sup 0/. In every case, the experimental profiles are compared with the predictions of a coupled electron/photon Monte Carlo transport code. Overall agreement between theory and experiment is very good. However, there appears to be a tendency for the theoretical profiles to be higher near the peaks and lower near the tails, especially in high-Z materials. There is also a discrepancy between theory and experiment in low-Z materials near high-Z/low-Z interfaces.

  19. Thermodynamic model for calorimetric and phase coexistence properties of coal derived fluids

    SciTech Connect

    Kabadi, V.N.

    1990-01-01

    A model for phase equilibria of coal derived liquids is to be extended to include calorimetric properties as well. To accomplish this satisfactorily, the proposed work includes three tasks: (1) Refinement of the characterization procedure to include distribution of sulfur, oxygen, and nitrogen heteroatoms in coal liquids; (2) Measurement of high temperature (up to 400{degrees}C) and high pressure (up to 1000 psi) VLE data for binary systems of selected model compounds; and (3) Development of the thermodynamic model. The final product will include a computer program which with measurable properties of coal liquids as input, will give results for phase coexistence properties and excess enthalpies in the liquid phase. Efforts are continuing to apply the new thermodynamic model for VLE and enthalpy predictions for coal liquids by the methods of continuous thermodynamics. Recently, Thompson, Brobst and Hankinson have developed an equation of state that represents compressibilities of liquids very well. The authors have undertaken the task of combining this equation of state with their thermodynamic model to provide a comprehensive model for high pressure liquid mixtures. Calibration and preliminary set-up procedure for the VLE apparatus with the new liquid level sensor have been completed. The apparatus is currently being tested with the binary system quinoline-tetralin. Chromatographic characterization work was delayed because of complexities of the calibration procedure and tedious calculations necessary for number average and weight average molecular weights. Results on the chromatographic studies are being deferred until computer software is received.

  20. The Calorimetric Electron Telescope (CALET) for High Energy Astroparticle Physics on the International Space Station

    NASA Astrophysics Data System (ADS)

    Torii, Shoji

    The Calorimetric Electron Telescope, CALET, space experiment, currently under development by Japan in collaboration with Italy and the United States, will measure the flux of Cosmic Ray electrons (and positrons) t o 20 TeV, gamma rays to 10 TeV , nuclei with Z=1 to 40 up to 1,000 TeV, and Gamma-ray bursts in the 7 keV- 10 MeV energy range during a five year mission. These measurements are essential to investigate possible nearby astrophysical sources of high energy electrons, study the details of galactic particle propagation and search for dark matter signatures. The main detector of Calet, the Calorimeter, consists of a module to identify the particle charge, followed by a thin imaging calorimeter (3 radiation lengths) with tungsten plates interleaving scintillating fiber planes, and a thick energy measuring calorimeter (27 radiation lengths) composed of lead tungstate logs. The Calorimeter has the depth, imaging capabilities and energy resolution necessary for excellent separation between hadrons, electrons and gamma rays. The instrument is currently being prepared for launch, during the Japan Fiscal Year (April, 2014- March, 2015) time frame, to the International Space Station (ISS) for installation on the Japanese Experiment Module - Exposure Facility (JEM-EF).

  1. Status and performance of the CALorimetric Electron Telescope (CALET) on the International Space Station

    NASA Astrophysics Data System (ADS)

    Adriani, O.; Akaike, Y.; Asaoka, Y.; Asano, K.; Bagliesi, M. G.; Bigongiari, G.; Binns, W. R.; Bongi, M.; Buckley, J. H.; Cassese, A.; Castellini, G.; Cherry, M. L.; Collazuol, G.; Ebisawa, K.; Di Felice, V.; Fuke, H.; Guzik, T. G.; Hams, T.; Hasebe, N.; Hareyama, M.; Hibino, K.; Ichimura, M.; Ioka, K.; Israel, M. H.; Javaid, A.; Kamioka, E.; Kasahara, K.; Katayose, Y.; Kataoka, J.; Kataoka, R.; Kawanaka, N.; Kitamura, H.; Kotani, T.; Krawczynski, H. S.; Krizmanic, J. F.; Kubota, A.; Kuramata, S.; Lomtadze, T.; Maestro, P.; Marcelli, L.; Marrocchesi, P. S.; Mitchell, J. W.; Miyake, S.; Mizutani, K.; Motz, H. M.; Moiseev, A. A.; Mori, K.; Mori, M.; Mori, N.; Munakata, K.; Murakami, H.; Nakagawa, Y. E.; Nakahira, S.; Nishimura, J.; Okuno, S.; Ormes, J. F.; Ozawa, S.; Palma, F.; Papini, P.; Rauch, B. F.; Ricciarini, S.; Sakamoto, T.; Sasaki, M.; Shibata, M.; Shimizu, Y.; Shiomi, A.; Sparvoli, R.; Spillantini, P.; Takahashi, I.; Takayanagi, M.; Takita, M.; Tamura, T.; Tateyama, N.; Terasawa, T.; Tomida, H.; Torii, S.; Tunesada, Y.; Uchihori, Y.; Ueno, S.; Vannuccini, E.; Wefel, J. P.; Yamaoka, K.; Yanagita, S.; Yoshida, A.; Yoshida, K.; Yuda, T.

    2014-11-01

    The CALorimetric Electron Telescope (CALET) space experiment, currently under development by Japan in collaboration with Italy and the United States, will measure the flux of cosmic-ray electrons (including positrons) to 20 TeV, gamma rays to 10 TeV and nuclei with Z=1 to 40 up to 1,000 TeV during a two-year mission on the International Space Station (ISS), extendable to five years. These measurements are essential to search for dark matter signatures, investigate the mechanism of cosmic-ray acceleration and propagation in the Galaxy and discover possible astrophysical sources of high-energy electrons nearby the Earth. The instrument consists of two layers of segmented plastic scintillators for the cosmic-ray charge identification (CHD), a 3 radiation length thick tungsten-scintillating fiber imaging calorimeter (IMC) and a 27 radiation length thick lead-tungstate calorimeter (TASC). CALET has sufficient depth, imaging capabilities and excellent energy resolution to allow for a clear separation between hadrons and electrons and between charged particles and gamma rays. The instrument will be launched to the ISS within 2014 Japanese Fiscal Year (by the end of March 2015) and installed on the Japanese Experiment Module-Exposed Facility (JEM-EF). In this paper, we will review the status and main science goals of the mission and describe the instrument configuration and performance.

  2. Calorimetric studies of the ammonia-water system with application to the outer solar system

    NASA Technical Reports Server (NTRS)

    Yarger, Jeffery; Lunine, Jonathan I.; Burke, Michael

    1993-01-01

    A series of heating experiments was performed on the condensed ammonia-water system using a differential scanning calorimeter (DSC). The water-rich samples were cooled quickly to below 130 K, then heated at a variety of rates. Rather than a single peritectic melt at 176 K, expected for the equilibrium system of water ice and ammonia dihydrate, four enthalpic transitions were repeatedly seen in the temperature range 150-176 K. These transitions are generally consistent with the earlier calorimetric results of Van Kasteren (1973), who interpreted the lowest temperature exotherm as crystallization of an amorphous ammonia-water compound formed during cooling. We propose that both sets of experiments are seeing the crystallization of ammonia monohydrate, which is metastable relative to the dihydrate, followed by partial remelting and crystallization of dihydrate upon further heating. The apparent stability of the monohydrate in the dihydrate equilibrium field implies a potentially complex behavior of ammonia-water ices in satellites. Possible self-heating of the mixture by several tens of degrees up to the 170 K eutectic could make mobilization of ammonia-water liquids in icy satellite interiors energetically easier than previously thought.

  3. Effect of sulfoxides on the thermal denaturation of hen lysozyme: A calorimetric and Raman study

    NASA Astrophysics Data System (ADS)

    Torreggiani, A.; Di Foggia, M.; Manco, I.; De Maio, A.; Markarian, S. A.; Bonora, S.

    2008-11-01

    A multidisciplinary study of the thermal denaturation of lysozyme in the presence of three sulfoxides with different length in hydrocarbon chain (DMSO, DESO, and DPSO) was carried out by means of DSC, Raman spectroscopy, and SDS-PAGE techniques. In particular, the Td and Δ H values obtained from the calorimetric measurements showed that lysozyme is partially unfolded by sulfoxides but most of the conformation holds native state. The sulfoxide denaturing ability increases in the order DPSO > DESO > DMSO. Moreover, only DMSO and DESO have a real effect in preventing the heat-induced inactivation of the protein and their maximum heat-protective ability is reached when the DMSO and DESO amount is ⩾25% w/w. The sulfoxide ability to act as effective protective agents against the heat-induced inactivation was confirmed by the protein analysis. The enzymatic activity, as well as the SDS-PAGE analysis, suggested that DESO, having a low hydrophobic character and a great ability to stabilise the three-dimensional water structure, is the most heat-protective sulfoxide. An accurate evaluation of the heat-induced conformational changes of the lysozyme structure before and after sulfoxide addition was obtained by the analysis of the Raman spectra. The addition of DMSO or DESO in low concentration resulted to sensitively decrease the heat-induced structural modifications of the protein.

  4. Characterization of commercial Li-ion batteries using electrochemical-calorimetric measurements

    NASA Astrophysics Data System (ADS)

    Al Hallaj, S.; Prakash, J.; Selman, J. R.

    Commercial Li-ion cells of Type 18650 dimensions and prismatic designs from different manufacturers have been tested to evaluate their performance and to study their thermal behavior using electrochemical-calorimetric methods. All cells tested in this work showed good performance and cyclability under normal operating conditions. The measured heat effect for the cells were exothermic during discharge and partially endothermic during charge. Cell impedance was measured for selected cells and showed some dependence on the state of charge or depth of discharge, with significant increase at the end of discharge due to concentration polarization. The entropy coefficient (d Eeq/d T) for the A&T (18650) and Panasonic (CGR 18650) cells were measured using potentiometric methods at different depths of discharge (DOD). The measured values for both cells showed some dependence on the DOD with some perturbation near 4.0 V, where the measured d Eeq/d T for Panasonic cell had an unexpected positive value. This was found to be consistent with the measured endothermic heat effect during discharge for the Panasonic cell near Eeq=4.0 V. This may be related to a phase change in the LiCoO 2 cathode material, as reported in the literature, and to structural transformation in the graphite used as anode material, in the Panasonic cell.

  5. Calorimetric and theoretical study of the interaction between some saccharides and sodium halide in water.

    PubMed

    Zhuo, Kelei; Fu, Yingyi; Bai, Guangyue; Wang, Jianji; Yan, Haike; Wang, Hanqing

    2012-08-23

    Dilution enthalpies and mixing enthalpies of sodium halide and some saccharides (glucose, galactose, xylose, arabinose, fructose, and sucrose) in aqueous solution were determined by calorimetric measurements at 298.15 K. The values were used to determine enthalpic pair interaction parameters. Combined with Gibbs energy pair parameters, entropic pair interaction parameters were also obtained. Theoretical calculations at the B3LYP/6-311++G(d,p) level were carried out to provide the information of structures and thermodynamic functions. The information reveals the thermodynamic essence of the interactions between sodium halide and saccharides in aqueous solutions. The experimental results and theoretical calculations show that the sign of enthalpic pair interaction parameter 2υh(ES) is determined by the direct interaction between saccharides and ions, whereas the difference in value of 2υh(ES) for different saccharides or electrolytes depends on the partial dehydration of saccharides or anions in aqueous solution. The difference in value of entropic pair interaction parameters depends partly on the different dominant interactions in the process of partial dehydration of saccharides or ions. An enthalpy-entropy compensation relationship was observed for the sodium bromide-aldopyranose-water systems. Remarkably, it can be conjectured that the hydration entropy of glucose is lower than for other monosaccharides. Perhaps it is one of the reasons why glucose plays an important role in living organisms rather than other monosaccharides. PMID:22779908

  6. Algorithms for Identification of Nearly-Coincident Events in Calorimetric Sensors

    NASA Astrophysics Data System (ADS)

    Alpert, B.; Ferri, E.; Bennett, D.; Faverzani, M.; Fowler, J.; Giachero, A.; Hays-Wehle, J.; Maino, M.; Nucciotti, A.; Puiu, A.; Swetz, D.; Ullom, J.

    2016-07-01

    For experiments with high arrival rates, reliable identification of nearly-coincident events can be crucial. For calorimetric measurements to directly measure the neutrino mass such as HOLMES, unidentified pulse pile-ups are expected to be a leading source of experimental error. Although Wiener filtering can be used to recognize pile-up, it suffers from errors due to pulse shape variation from detector nonlinearity, readout dependence on subsample arrival times, and stability issues from the ill-posed deconvolution problem of recovering Dirac delta-functions from smooth data. Due to these factors, we have developed a processing method that exploits singular value decomposition to (1) separate single-pulse records from piled-up records in training data and (2) construct a model of single-pulse records that accounts for varying pulse shape with amplitude, arrival time, and baseline level, suitable for detecting nearly-coincident events. We show that the resulting processing advances can reduce the required performance specifications of the detectors and readout system or, equivalently, enable larger sensor arrays and better constraints on the neutrino mass.

  7. An IR and Calorimetric Investigation of the Structural, Crystal-Chemical and Thermodynamic Properties of Hydrogrossular

    NASA Astrophysics Data System (ADS)

    Geiger, C. A.; Dachs, E.

    2012-04-01

    their collective interactions measurably affect the lattice dynamic (i.e. thermodynamic) behavior. The low temperature heat capacity behavior was investigated with a commercially designed relaxation calorimeter between 5 and 300 K on a mg-sized sample. The heat capacity data are well behaved at T < 300 K and show a monotonic decrease in magnitude with decreasing temperature. A standard third-law entropy value of So = 421.7 ± 1.6 J/mol·K was calculated. Using this new calorimetric-based So value and published standard enthalpy of formation data for katoite, a calorimetric-based Gibbs free energy of formation at 298 K can be obtained as ΔG°f = -5021.2 kJ/mol. The Cp data show no evidence for any phase transition as possibly expected by the change in OH-mode behavior with decreasing temperature. We have no explanation for the appearance of the additional modes. It is worth noting that the katoite crystal structure in terms of lattice dynamic or thermodynamic behavior should be thought of having OH groups and not O4H4 clusters or polyhedral units as is often written in the literature. The single crystallographic OH group in katoite shows very weak, if any, hydrogen bonding and the H atoms have large amplitudes of vibration. The weak H bonding controls the nature of low energy OH-related vibrations and this leads to its large So value.

  8. Seasonal Variability in Calorimetric Energy Content of Two Caribbean Mesophotic Corals.

    PubMed

    Brandtneris, Viktor W; Brandt, Marilyn E; Glynn, Peter W; Gyory, Joanna; Smith, Tyler B

    2016-01-01

    Energetic responses of zooxanthellate reef corals along depth gradients have relevance to the refugia potential of mesophotic coral ecosystems (MCEs). Previous observations suggested that MCEs in the Caribbean are thermally buffered during the warmest parts of the year and occur within or just below the chlorophyll maximum, suggesting abundant trophic resources. However, it is not known if mesophotic corals can maintain constant energy needs throughout the year with changing environmental and biological conditions. The energetic content of tissues from the stony coral species Orbicella faveolata and Agaricia lamarcki was measured on the southern insular shelf of St. Thomas, US Virgin Islands (USVI), using micro-bomb calorimetry. Three sites for each species, at depths of 6m, 25m, 38m and 63m, were selected to capture energetic differences across the major vertical range extent of both species in the USVI-and sampled over five periods from April 2013 to April 2014. Mesophotic colonies of O. faveolata exhibited a significant reduction in energetic content during the month of September 2013 compared to mid-depth and shallow colonies (p = 0.032), whereas A. lamarcki experienced similar energetic variability, but with a significant reduction in energy content that occurred in July 2013 for colonies at sites deeper than 25m (p = 0.014). The results of calorimetric analyses indicate that O. faveolata may be at risk during late summer stress events, possibly due to the timing of reproductive activities. The low-point of A. lamarcki energy content, which may also coincide with reproduction, occurs prior to seasonal stress events, indicating contrasting, species-specific responses to environmental variability on MCEs. PMID:27050430

  9. Calorimetric Study of Magnetic Field-Induced Phase Transitions in - Fulvalenium) -

    NASA Astrophysics Data System (ADS)

    Fortune, Nathanael Alexander

    The particular class of organic conductors known as the Bechgaard salts exhibit a variety of highly anisotropic magnetic, thermal, and electrical phenomena. At low temperatures (below 10 kelvin), the application of a strong magnetic field establishes an effectively lower-dimensional anisotropic Fermi surface, as manifested in a variety of quasi one dimensional and quasi two dimensional thermodynamic and transport properties. Most dramatically, an increasing magnetic field--after suppression of superconductivity, induces a second order phase transition from a metallic to a spin density wave semimetal, followed by a series of first order phase transitions between density wave semimetallic states. This thesis concerns the thermodynamic nature of the low temperature magnetic field induced phase transitions in the Bechgaard charge-transfer salt (TMTSF)2-Cl(O)4. Presented here are the first measurements of the specific heat in magnetic fields up to 30 tesla, as well as the design and construction of a small sample calorimeter capable of operating at dilution refrigerator temperatures in the challenging environment of the high field resistive Bitter magnets. From transport measurements, the existence of a magnetic field induced reentrance into the metallic state has previously been inferred. In this thesis, the unambiguous bulk thermodynamic character of the reentrance is calorimetrically demonstrated. The behavior of the electronic specific heat at the reentrant transition is shown to be consistent with magnetic field enhanced localization. Additionally, quantum oscillations in the high field semimetallic state and the presence of additional structure above the reentrant field are observed. Although these oscillations have also been observed in magnetoresistance and magnetization, the magnitude of the oscillations in the specific heat calls into question all known models for the physical origin of these oscillations.

  10. Thermodynamic model for calorimetric and phase coexistence properties of coal derived fluids. Final technical report

    SciTech Connect

    Kabadi, V.N.

    1992-10-01

    The work on this project was initiated on September 1, 1989. The project consisted of three different tasks. 1. A thermodynamic model to predict VLE and calorimetric properties of coal liquids. 2. VLE measurements at high temperature and high pressure for coal model compounds and 3. Chromatographic characterization of coal liquids for distribution of heteroatoms. The thermodynamic model developed is an extension of the previous model developed for VLE of coal derived fluids (DOE Grant no. FG22-86PC90541). The model uses the modified UNIFAC correlation for the liquid phase. Some unavailable UNIFAC interactions parameters have been regressed from experimental VLE and excess enthalpy data. The model is successful in predicting binary VLE and excess enthalpy data. Further refinements of the model are suggested. An apparatus for the high pressure high temperature VLE data measurements has been built and tested. Tetralin-Quinoline is the first binary system selected for data measurements. The equipment was tested by measuring 325{degree}C isotherm for this system and comparing it with literature data. Additional isotherms at 350{degree}C and 370{degree}C have been measured. The framework for a characterization procedure for coal derived liquids has been developed. A coal liquid is defined by a true molecular weight distribution and distribution of heteroatoms as a function of molecular weights. Size exclusions liquid chromatography, elemental analysis and FTIR spectroscopy methods are used to obtain the molecular weight and hetroatom distributions. Further work in this area should include refinements of the characterization procedure, high temperature high pressure VLE data measurements for selective model compound binary systems, and improvement of the thermodynamic model using the new measured data and consistent with the developments in the characterization procedure.

  11. Calorimetric measurement of afterheat in target materials for the accelerator production of tritium

    SciTech Connect

    Perry, R.B.; Zucker, M.S.

    1994-06-01

    The estimate of afterheat in a spallation target of lead (Pb) or tungsten (W), by calorimetry, is the purpose of this experiment in support of the Accelerator Production of Tritium (APT). Such measurements are needed to confirm code calculations, these being the only practical way of gaining this type of information in a form suitable to aid the design of the APT machine. Knowledge of the magnitude and duration of afterheat resulting from decay of activation products produced by proton bombardment of the target is necessary to quantify APT safety assumptions, to design target cooling and safety systems, and to reduce technical risk. Direct calorimetric measurement of the afterheat for the appropriate incident proton energies is more reliable than the available alternative, which is indirect, based on data from gamma-ray spectroscopy measurements. The basic concept, a direct measurement of decay afterheat which bypasses the laborious classical way of determining this quantity, has been demonstrated to work. The gamma-ray energy given off by the decay products produced in the activation of lead or tungsten with high-energy protons apparently does represent a significant fraction of the total decay energy. A calorimeter designed for measurement of isotopes decaying by alpha emission must be modified to reduce energy lost with escaping gamma rays. Replacement of the aluminum liner with a tungsten liner in the SSC measurement chamber resulted in a 270% increase in measured heat, proving that the energy loss in the earlier (1992) measurements was significant. Gamma-ray measurements are needed to confirm the gamma-ray absorption calculations for the calorimeter to determine the correction for loss of heat due to transmission of high-energy gamma rays through the calorimeter walls. The experiments at BLIP have shown that calorimetry can be a useful tool in measuring the afterheat in APT target materials.

  12. Calorimetric studies of the kinetic unfreezing of molecular motions in hydrated lysozyme, hemoglobin, and myoglobin.

    PubMed Central

    Sartor, G; Mayer, E; Johari, G P

    1994-01-01

    Differential scanning calorimetric (DSC) studies of the glassy states of as-received and hydrated lysozyme, hemoglobin, and myoglobin powders, with water contents of < or = 0.25, < or = 0.30, and < or = 0.29 g/g of protein, show that their heat capacity slowly increases with increasing temperature, without showing an abrupt increase characteristic of glass-->liquid transition. Annealing (also referred to as physical aging) of the hydrated proteins causes their DSC scans to show an endothermic region, similar to an overshoot, immediately above the annealing temperature. This annealing effect appears at all temperatures between approximately 150 and 300 K. The area under these peaks increases with increasing annealing time at a fixed temperature. The effects are attributed to the presence of a large number of local structures in which macromolecular segments diffuse at different time scales over a broad range. The lowest time scale corresponds to the > N-H and -O-H group motions which become kinetically unfrozen at approximately 150-170 K on heating at a rate of 30 K min-1 and which have a relaxation time of 5-10 s in this temperature range. The annealing effects confirm that the individual glass transition of the relaxing local regions is spread over a temperature range up to the denaturation temperature region of the proteins. The interpretation is supported by simulation of DSC scans in which the distribution of relaxation times is assumed to be exceptionally broad and in which annealing done at several temperatures over a wide range produces endothermic effects (or regions of DSC scans) qualitatively similar to those observed for the hydrated proteins. PMID:8130342

  13. Seasonal Variability in Calorimetric Energy Content of Two Caribbean Mesophotic Corals

    PubMed Central

    Brandtneris, Viktor W.; Brandt, Marilyn E.; Glynn, Peter W.; Gyory, Joanna; Smith, Tyler B.

    2016-01-01

    Energetic responses of zooxanthellate reef corals along depth gradients have relevance to the refugia potential of mesophotic coral ecosystems (MCEs). Previous observations suggested that MCEs in the Caribbean are thermally buffered during the warmest parts of the year and occur within or just below the chlorophyll maximum, suggesting abundant trophic resources. However, it is not known if mesophotic corals can maintain constant energy needs throughout the year with changing environmental and biological conditions. The energetic content of tissues from the stony coral species Orbicella faveolata and Agaricia lamarcki was measured on the southern insular shelf of St. Thomas, US Virgin Islands (USVI), using micro-bomb calorimetry. Three sites for each species, at depths of 6m, 25m, 38m and 63m, were selected to capture energetic differences across the major vertical range extent of both species in the USVI—and sampled over five periods from April 2013 to April 2014. Mesophotic colonies of O. faveolata exhibited a significant reduction in energetic content during the month of September 2013 compared to mid-depth and shallow colonies (p = 0.032), whereas A. lamarcki experienced similar energetic variability, but with a significant reduction in energy content that occurred in July 2013 for colonies at sites deeper than 25m (p = 0.014). The results of calorimetric analyses indicate that O. faveolata may be at risk during late summer stress events, possibly due to the timing of reproductive activities. The low-point of A. lamarcki energy content, which may also coincide with reproduction, occurs prior to seasonal stress events, indicating contrasting, species-specific responses to environmental variability on MCEs. PMID:27050430

  14. NEP facilities (LeRC)

    NASA Astrophysics Data System (ADS)

    Vetrone, Robert H.

    The topics are presented in viewgraph form and include the following: the Electric Propulsion Research Building (no. 16) the Electric Power Laboratory (BLDG. 301); the Tank 6 Vacuum Facility; and test facilities for electric propulsion and LeRC.

  15. Le bégaiement

    PubMed Central

    Perez, Hector R.; Stoeckle, James H.

    2016-01-01

    Résumé Objectif Fournir une mise à jour sur l’épidémiologie, l’hérédité, la physiopathologie, le diagnostic et le traitement du bégaiement développemental. Qualité des données Une recherche d’études récentes ou non portant sur l’épidémiologie, l’hérédité, la physiopathologie, le diagnostic et le traitement du bégaiement développemental a été effectuée dans les bases de données MEDLINE et Cochrane. La plupart des recommandations s’appuient sur des études de petite envergure, des données probantes de qualité limitée ou des consensus. Message principal Le bégaiement est un trouble d’élocution fréquent chez les personnes de tous âges, il altère la fluidité verbale normale et l’enchaînement du discours. Le bégaiement a été lié à des différences de l’anatomie, du fonctionnement et de la régulation dopaminergique du cerveau qui seraient de source génétique. Il importe de poser le diagnostic avec attention et de faire les recommandations qui conviennent chez les enfants, car de plus en plus, le consensus veut que l’intervention précoce par un traitement d’orthophonie soit cruciale chez les enfants bègues. Chez les adultes, le bégaiement est lié à une morbidité psychosociale substantielle, dont l’anxiété sociale et une piètre qualité de vie. Les traitements pharmacologiques ont soulevé l’intérêt depuis quelques années, mais les données cliniques sont limitées. Le traitement des enfants et des adultes repose sur l’orthophonie. Conclusion De plus en plus de recherches ont tenté de lever le voile sur la physiopathologie du bégaiement. La meilleure solution pour les enfants et les adultes bègues demeure la recommandation à un traitement d’orthophonie.

  16. Analbite - Sanidine Thermodynamic Mixing Properties: Highly Precise HF Solution Calorimetric Data Across A Twenty-Member Crystalline Solution Series

    NASA Astrophysics Data System (ADS)

    Hovis, G. L.

    2013-12-01

    Enthalpies of K-Na mixing for the analbite - sanidine feldspar series were investigated by Hovis (1988, J. Petrology) in the early 80's. That work was based on data at a limited number of compositions, owing to the large sample sizes required for HF solution calorimetric measurements at the time. Thermodynamic mixing properties for mineral series, especially those exhibiting compositionally asymmetric mixing quantities, are best defined when samples at a large number of compositions are utilized. Enabled by the small sample sizes now possible for HF solution calorimetric dissolutions (Hovis et al., 1998, Amer. Mineral.), we revisit feldspar thermodynamic properties, having synthesized an analbite - sanidine series consisting of samples at 20 compositions. Solution calorimetric experiments on these samples at 50 °C in 20.1 wt% HF under isoperibolic conditions have resulted in highly precise calorimetric data (standard deviation per sample averaging 0.06 % of the heat of solution). Although enthalpies of K-Na mixing based on the new data display some degree of compositional asymmetry, with a maximum value of 4.8 kJ/mol at a mole fraction potassium of 0.47, the distribution of enthalpy-of-mixing values remains nearly symmetric with respect to K content. This contrasts significantly with data for Al-Si ordered low albite - microcline crystalline solutions, reinvestigated via synthesis of a 21-member series, which show significantly higher mixing magnitudes and considerably greater asymmetry with respect to composition. The maximization of enthalpies of K-Na mixing at sodic compositions correlates well with the sodic critical compositions for both solvi. The lower mixing magnitudes for analbite - sanidine are consistent with the comparatively lower critical temperature of the analbite - sanidine solvus (e.g., Smith & Parsons, 1974, Mineral. Mag.) relative to that for low albite - microcline (Bachinski & Müller, 1971, J. Petrology). Entropies of K-Na mixing for

  17. Analbite - Sanidine Thermodynamic Mixing Properties: Highly Precise HF Solution Calorimetric Data Across A Twenty-Member Crystalline Solution Series

    NASA Astrophysics Data System (ADS)

    Hovis, G. L.

    2012-12-01

    Enthalpies of K-Na mixing for the analbite - sanidine feldspar series were investigated by Hovis (1988, J. Petrology) in the early 80's. That work was based on data at a limited number of compositions, owing to the large sample sizes required for HF solution calorimetric measurements at the time. Thermodynamic mixing properties for mineral series, especially those exhibiting compositionally asymmetric mixing quantities, are best defined when samples at a large number of compositions are utilized. Enabled by the small sample sizes now possible for HF solution calorimetric dissolutions (Hovis et al., 1998, Amer. Mineral.), we revisit feldspar thermodynamic properties, having synthesized an analbite - sanidine series consisting of samples at 20 compositions. Solution calorimetric experiments on these samples at 50 °C in 20.1 wt% HF under isoperibolic conditions have resulted in highly precise calorimetric data (standard deviation per sample averaging 0.06 % of the heat of solution). Although enthalpies of K-Na mixing based on the new data display some degree of compositional asymmetry, with a maximum value of 4.8 kJ/mol at a mole fraction potassium of 0.47, the distribution of enthalpy-of-mixing values remains nearly symmetric with respect to K content. This contrasts significantly with data for Al-Si ordered low albite - microcline crystalline solutions, reinvestigated via synthesis of a 21-member series, which show significantly higher mixing magnitudes and considerably greater asymmetry with respect to composition. The maximization of enthalpies of K-Na mixing at sodic compositions correlates well with the sodic critical compositions for both solvi. The lower mixing magnitudes for analbite - sanidine are consistent with the comparatively lower critical temperature of the analbite - sanidine solvus (e.g., Smith & Parsons, 1974, Mineral. Mag.) relative to that for low albite - microcline (Bachinski & Müller, 1971, J. Petrology). Entropies of K-Na mixing for

  18. Investigation of ferroelectric phase transitions of water in nanoporous silicates in simultaneous electrical noise and calorimetric measurements

    NASA Astrophysics Data System (ADS)

    Bordonskiy, G. S.; Orlov, A. O.

    2014-08-01

    The phase transitions of water in the nanoporous silicate materials SBA-15 and MCM-41 with an ordered system of cylindrical pores have been investigated. Measurements of low-frequency electrical noises (Barkhausen noises) in the frequency range of 1-100 Hz have been performed simultaneously with relative calorimetric measurements. It has been found that the voltage of electrical fluctuations increases approximately 100 times in the temperature range from -30 to -50°C, which is associated with the first-order and second-order ferroelectric phase transitions. It has been assumed that the ferroelectric ice XI can be formed in capillary pores of the materials under investigations.

  19. Le pompage optique naturel dans le milieu astrophysique

    NASA Astrophysics Data System (ADS)

    Pecker, J.-C.

    The title of this lecture abstracts only a part of it : the importance in astrophysics of the study of non-LTE situations has become considerable, as well in the stellar atmospheres as, still more, in the study of fortuitous coincidences as a mechanism of formation of emission line nebular spectra, or of molecular interstellar « masers ». Another part of this talk underlines the role of Kastler in his time, and describes his warm personality through his public reactions in front of the nuclear armement, of the Viet-Nam and Algerian wars, of the problems of political refugees... Kastler was a great scientist ; he was also a courageous humanist. 1976 : Les accords nucléaires du Brésil : allocution d'ouverture (19 mars). Colloque sur le sujet ci-dessus. 1976 : La promotion de la culture dans le nouvel ordre économique international, allocution à l'occasion d'une table ronde sur ce thème par l'UNESCO (23-27 juin 1976) ; « Sciences et Techniques », octobre 1976. 1979 : La bête immonde (avec J.-C. Pecker), « Le Matin », 20 mars. 1979 : Appel à nos ministres (avec J.-C. Pecker), « Le Monde », 13 décembre. 1979 : Le flou, le ténébreux, l'irrationnel (avec J.-C. Pecker), « Le Monde », 14 septembre. 1980 : Education à la paix, Préface, in : Publ. UNESCO. 1981 : Le vrai danger, « Le Monde », 6 août 1981. 1982 : Nucléaire civil et militaire, « Le Monde », 1er juin 1982. 1982 : Les scientifiques face à la perspective d'holocauste nucléaire (texte inédit). Le titre de cette communication en résume seulement une partie : l'importance prise en astrophysique par l'analyse des situations hors ETL est devenue considérable, qu'il s'agisse des atmosphères stellaires, ou plus encore, des coïncidences fortuites de la formation des spectres d'émission nébulaires, ou des « masers » moléculaires interstellaires. Une autre partie de cet exposé souligne lele de Kastler dans son époque, et décrit sa personnalité généreuse à travers ses r

  20. Calorimetric and spectroscopic studies of aminoglycoside binding to AT-rich DNA triple helices

    PubMed Central

    Xi, Hongjuan; Kumar, Sunil; Dosen-Micovic, Ljiljana; Arya, Dev P.

    2013-01-01

    Calorimetric and fluorescence techniques were used to characterize the binding of aminoglycosides-neomycin, paromomycin, and ribostamycin, with 5′-dA12-x-dT12-x-dT12-3′ intramolecular DNA triplex (x = hexaethylene glycol) and poly(dA).2poly(dT) triplex. Our results demonstrate the following features: (1) UV thermal analysis reveals that the Tm for triplex decreases with increasing pH value in the presence of neomycin, while the Tm for the duplex remains unchanged. (2) The binding affinity of neomycin decreases with increased pH, although there is an increase in observed binding enthalpy. (3) ITC studies conducted in two buffers (sodium cacodylate and MOPS) yield the number of protonated drug amino groups (Δn) as 0.29 and 0.40 for neomycin and paromomycin interaction with 5′-dA12-x-dT12-x-dT12-3′, respectively. (4) The specific heat capacity change (ΔCp) determined by ITC studies is negative, with more negative values at lower salt concentrations. From 100 mM to 250 mM KCl, the ΔCp ranges from −402 to −60 cal/(mol K) for neomycin. At pH 5.5, a more positive ΔCp is observed, with a value of −98 cal/(mol K) at 100 mM KCl. ΔCp is not significantly affected by ionic strength. (5) Salt dependence studies reveal that there are at least three amino groups of neomycin participating in the electrostatic interactions with the triplex. (6) FID studies using thiazole orange were used to derive the AC50 (aminoglycoside concentration needed to displace 50% of the dye from the triplex) values. Neomycin shows a seven fold higher affinity than paromomycin and eleven fold higher affinity than ribostamycin at pH 6.8. (7) Modeling studies, consistent with UV and ITC results, show the importance of an additional positive charge in triplex recognition by neomycin. The modeling and thermodynamic studies indicate that neomycin binding to the DNA triplex depends upon significant contributions from charge as well as shape complementarity of the drug to the DNA triplex

  1. Investigation of a zirconia co-fired ceramic calorimetric microsensor for high-temperature flow measurements

    NASA Astrophysics Data System (ADS)

    Lekholm, Ville; Persson, Anders; Klintberg, Lena; Thornell, Greger

    2015-06-01

    This paper describes the design, fabrication and characterization of a flow sensor for high-temperature, or otherwise aggressive, environments, like, e.g. the propulsion system of a small spacecraft. The sensor was fabricated using 8 mol% yttria stabilized zirconia (YSZ8) high-temperature co-fired ceramic (HTCC) tape and screen printed platinum paste. A calorimetric flow sensor design was used, with five 80 µm wide conductors, separated by 160 µm, in a 0.4 mm wide, 0.1 mm deep and 12.5 mm long flow channel. The central conductor was used as a heater for the sensor, and the two adjacent conductors were used to resistively measure the heat transferred from the heater by forced convection. The two outermost conductors were used to study the influence of an auxiliary heat source on the sensor. The resistances of the sensor conductors were measured using four-point connections, as the gas flow rate was slowly increased from 0 to 40 sccm, with different power supplied through the central heater, as well as with an upstream or downstream heater powered. In this study, the thermal and electrical integrability of microcomponents on the YSZ8 substrate was of particular interest and, hence, the influence of thermal and ionic conduction in the substrate was studied in detail. The effect of the ion conductivity of YSZ8 was studied by measuring the resistance of a platinum conductor and the resistance between two adjacent conductors on YSZ8, in a furnace at temperatures from 20 to 930 °C and by measuring the resistance with increasing current through a conductor. With this design, the influence of ion conductivity through the substrate became apparent above 700 °C. The sensitivity of the sensor was up to 1 mΩ sccm-1 in a range of 0-10 sccm. The results show that the signal from the sensor is influenced by the integrated auxiliary heating conductors and that these auxiliary heaters provide a way to balance disturbing heat sources, e.g. thrusters or other electronics, in

  2. Development of Metallic Magnetic Calorimeters for High Precision Measurements of Calorimetric Re-187 and Ho-163 Spectra

    NASA Technical Reports Server (NTRS)

    Ranitzsch, P. C.-O.; Porst, J.-P.; Kempf, S.; Pies, C.; Schafer, S.; Hengstler, D.; Fleischmann, A.; Enss, C.; Gastaldo, L.

    2012-01-01

    The measurement of calorimetric spectra following atomic weak decays, beta (b) and electron capture (EC), of nuclides having a very low Q-value, can provide an impressively high sensitivity to a non-vanishing neutrino mass. The achievable sensitivity in this kind of experiments is directly connected to the performance of the used detectors. In particular an energy resolution of a few eV and a pulse formation time well below 1 microsecond are required. Low temperature Metallic Magnetic Calorimeters (MMCs) for soft X-rays have already shown an energy resolution of 2.0 eV FWHM and a pulse rise-time of about 90 ns for fully micro-fabricated detectors. We present the use of MMCs for high precision measurements of calorimetric spectra following the beta-decay of Re-187 and the EC of Ho-163. We show results obtained with detectors optimized for Re-187 and for Ho-163 experiments respectively. While the detectors equipped with superconducting Re absorbers have not yet reached the aimed performance, a first detector prototype with a Au absorber having implanted Ho-163 ions already shows excellent results. An energy resolution of 12 eV FWHM and a rise time of 90 ns were measured.

  3. Urea-induced dissociation and unfolding of dodecameric glutamine synthetase from Escherichia coli: calorimetric and spectral studies.

    PubMed Central

    Zolkiewski, M.; Nosworthy, N. J.; Ginsburg, A.

    1995-01-01

    Urea-induced dissociation and unfolding of manganese.glutamine synthetase (Mn.GS) have been studied at 37 degrees C (pH 7) by spectroscopic and calorimetric methods. In 0 to approximately 2 M urea, Mn.GS retains its dodecameric structure and full catalytic activity. Mn.GS is dissociated into subunits in 6 M urea, as evidenced by a 12-fold decrease in 90 degrees light scattering and a monomer molecular weight of 51,800 in sedimentation equilibrium studies. The light scattering decrease in 4 M urea parallels the time course of Trp exposure but occurs more rapidly than changes in secondary structure and Tyr exposure. Early and late kinetic steps appear to involve predominantly disruption of intra-ring and inter-ring subunit contacts, respectively, in the layered hexagonal structure of Mn.GS. The enthalpies for transferring Mn.GS into urea solutions have been measured by titration calorimetry. After correcting for the enthalpy of binding urea to the protein, the enthalpy of dissociation and unfolding of Mn.GS is 14 +/- 4 cal/g. A net proton uptake of approximately 50 H+/dodecamer accompanies unfolding reactions. The calorimetric data are consistent with urea binding to multiple, independent sites in Mn.GS and the number of binding sites increasing approximately 9-fold during the protein unfolding. PMID:8520480

  4. Le LHC, un tunnel cosmique

    ScienceCinema

    None

    2011-10-06

    Et si la lumière au bout du tunnel du LHC était cosmique ? En d?autres termes, qu?est-ce que le LHC peut nous apporter dans la connaissance de l?Univers ? Car la montée en énergie des accélérateurs de particules nous permet de mieux appréhender l?univers primordial, chaud et dense. Mais dans quel sens dit-on que le LHC reproduit des conditions proches du Big bang ? Quelles informations nous apporte-t-il sur le contenu de l?Univers ? La matière noire est-elle détectable au LHC ? L?énergie noire ? Pourquoi l?antimatière accumulée au CERN est-elle si rare dans l?Univers ? Et si le CERN a bâti sa réputation sur l?exploration des forces faibles et fortes qui opèrent au sein des atomes et de leurs noyaux, est-ce que le LHC peut nous apporter des informations sur la force gravitationnelle qui gouverne l?évolution cosmique ? Depuis une trentaine d?années, notre compréhension de l?univers dans ses plus grandes dimensions et l?appréhension de son comportement aux plus petites distances sont intimement liées : en quoi le LHC va-t-il tester expérimentalement cette vision unifiée ? Tout public, entrée libre / Réservations au +41 (0)22 767 76 76

  5. Thermogravimetric and calorimetric characteristics during co-pyrolysis of municipal solid waste components.

    PubMed

    Ansah, Emmanuel; Wang, Lijun; Shahbazi, Abolghasem

    2016-10-01

    The thermogravimetric and calorimetric characteristics during pyrolysis of wood, paper, textile and polyethylene terephthalate (PET) plastic in municipal solid wastes (MSW), and co-pyrolysis of biomass-derived and plastic components with and without torrefaction were investigated. The active pyrolysis of the PET plastic occurred at a much higher temperature range between 360°C and 480°C than 220-380°C for the biomass derived components. The plastic pyrolyzed at a heating rate of 10°C/min had the highest maximum weight loss rate of 18.5wt%/min occurred at 420°C, followed by 10.8wt%/min at 340°C for both paper and textile, and 9.9wt%/min at 360°C for wood. At the end of the active pyrolysis stage, the final mass of paper, wood, textile and PET was 28.77%, 26.78%, 21.62% and 18.31%, respectively. During pyrolysis of individual MSW components at 500°C, the wood required the least amount of heat at 665.2J/g, compared to 2483.2J/g for textile, 2059.4J/g for paper and 2256.1J/g for PET plastic. The PET plastic had much higher activation energy of 181.86kJ/mol, compared to 41.47kJ/mol for wood, 50.01kJ/mol for paper and 36.65kJ/mol for textile during pyrolysis at a heating rate of 10°C/min. H2O and H2 peaks were observed on the MS curves for the pyrolysis of three biomass-derived materials but there was no obvious H2O and H2 peaks on the MS curves of PET plastic. There was a significant interaction between biomass and PET plastic during co-pyrolysis if the biomass fraction was dominant. The amount of heat required for the co-pyrolysis of the biomass and plastic mixture increased with the increase of plastic mass fraction in the mixture. Torrefaction at a proper temperature and time could improve the grindability of PET plastic. The increase of torrefaction temperature and time did not affect the temperature where the maximum pyrolytic rates occurred for both biomass and plastic but decreased the maximum pyrolysis rate of biomass and increased the maximum pyrolysis

  6. Le Planetaire (Around the World)

    ERIC Educational Resources Information Center

    Rebouillet, Andre; And Others

    1977-01-01

    This section, "Le Planetaire," contains an interview with Anne Slack on the American Association of Teachers of French and contemporary French culture, a review of a dictionary of familiar French for students, dates to remember, events of interest to French teachers and a general bibliography. (Text is in French.) (AMH)

  7. Calorimetric study of Te15(Se100- x Bi x )85 glassy alloys using differential thermal analysis

    NASA Astrophysics Data System (ADS)

    Kumar, Kameshwar; Thakur, Nagesh; Bhatt, S. S.; Sharma, Pankaj

    2010-10-01

    A calorimetric study of Te15(Se100- x Bi x )85 glassy alloys (x = 0, 1, 2, 3 and 4 at. %) is reported. Differential thermal analysis (DTA) was performed at heating rates of 10, 15, 20 and 25 K/min. The spectra were used to determine the glass transition temperature, Tg , the crystallisation temperature, Tc and the melting temperature, Tm . All these parameters shift to higher values with increasing heating rate, β. The glass transition temperature and the melting temperature increase, and the crystallisation temperature decreases, with increase in the Bi content, x. The activation energy of the glass transition, Eg , was evaluated using the Moynihan and Kissinger methods. The activation energy of crystallisation, Ec , was calculated using modified Kissinger and Matusita approaches. The thermal stability of these glasses has been studied and found to decrease with increase in Bi content. The results obtained are explained on the basis of a chemically ordered network model and an average coordination number.

  8. A micromachined calorimetric gas sensor: an application of electrodeposited nanostructured palladium for the detection of combustible gases.

    PubMed

    Bartlett, Philip N; Guerin, Samuel

    2003-01-01

    Palladium films with regular nanoarchitectures were electrochemically deposited from the hexagonal (H1) lyotropic liquid crystalline phase of the nonionic surfactant octaethyleneglycol monohexadecyl ether (C16EO8) onto micromachined silicon hotplate structures. The H1-e Pd films were shown to have high surface areas (approximately 28 m2 g(-1)) and to act as effective and stable catalysts for the detection of methane in air on heating to 500 degrees C. The response of the H1-e Pd-coated planar pellistors was found to be linearly proportional to the concentration of methane between 0 and 2.5% in air with a detection limit below 0.125%. Our results show that the electrochemical deposition of nanostructured metal films offers a promising approach to the fabrication of micromachined calorimetric gas sensors for combustible gases. PMID:12530828

  9. In re LePage.

    PubMed

    2001-01-01

    Court Decision: 18 Pacific Reporter, 3d Series 1177; 2001 Mar 8 (date of decision). The Supreme Court of Wyoming held that the state Department of Health was not authorized to inquire about the sincerity of a mother's religious beliefs when determining whether her daughter was exempt from a public school immunization requirement. Susan LePage submitted a request to the Department of Health seeking to exempt her daughter from receiving the hepatitis B vaccination. The Department of Health inquired into the sincerity of LePage's religious beliefs against vaccination and determined that her objections were of a personal or philosophical nature and not on religious grounds. The Department of Health denied LePage's request. The Supreme Court of Wyoming held that state law requires the Department of Health to grant an exemption upon the submission of a written objection and does not allow the Department of Health to make an inquiry into the sincerity of the requestor's religious beliefs. The court balanced a valid state interest in protecting schoolchildren from disease with the relatively low number of requests for exemption and its confidence in parents to make decisions in the best interest of their children's physical and spiritual health. Since there was no justification within the statute to allow a religious inquiry, the court held that the Department of Health had exceeded its authority with LePage. Furthermore, state law did not require a religious waiver to exempt a child from this particular vaccine. The lower court's holding was reversed. PMID:16479706

  10. Le Fevre [Le Fèvre; LeFebvre], Jean (1652-1706)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Born in Lisieux, France, became an associate of JEAN PICARD and PHILIPPE DE LA HIRE, became a member of the Académie des Sciences and worked on rather routine work calculating ephemeredes, and surveying. Le Fevre accused La Hire of stealing his tables after Philippe de La Hire published Tabulae Astronomicae in 1687. In 1701, resentful at not having been named official publisher of ephemerides to ...

  11. A Calorimetric Study of Almandine: Are the Thermodynamic Properties of the End-Member Aluminosilicate Garnets Finally Known Quantitatively?

    NASA Astrophysics Data System (ADS)

    Dachs, E.; Geiger, C. A.; Benisek, A.

    2012-12-01

    The aluminosilicate garnets (E3Al2Si3O12 with E = Fe2+, Mn2+, Ca, Mg) form an important rock-forming mineral group. Much study has been directed toward determining their thermodynamic properties. The iron end-member almandine (Fe3Al2Si3O12) is a key phase in many petrologic investigations. As part of an ongoing calorimetric and thermodynamic study of the aluminosilicate garnets, the heat capacity of three synthetic well-characterized polycrystalline almandine garnets and one natural almandine-rich single crystal was measured. The various garnets were characterized by optical microscopy, electron-microprobe analysis, X-ray powder diffraction and 57Fe Mössbauer spectroscopy. Heat capacity measurements were performed in the temperature range 3 to 300 K using relaxation calorimetry and between 282 and 764 K using DSC methods. From the former, So values between 336.7 ± 0.8 and 337.8 ± 0.8 J/molK are calculated for the different samples. The smaller value is considered the best So for end-member stoichiometric almandine, because it derives from the "best" Fe3+-free synthetic sample. The Cp behavior for almandine at T > 298 K is given by the polynomial (in J/molK): Cp = 649.06(±4) - 3837.57(±122)T-0.5 - 1.44682(±0.06)107T-2 + 1.94834(±0.09)109T-3, which is calculated using DSC data together with one published heat-content datum determined by transposed-drop calorimetry along with a new determination that gives H1181K - H302K = 415.0 ± 3.2 kJ/mole. Almandine shows a λ-type heat-capacity anomaly at low temperatures resulting from a paramagnetic-antiferromagnetic phase transition at about 9 K. The lattice heat capacity was calculated using the single-parameter phonon dispersion model of Komada and Westrum (1997), which allows the non-lattice heat capacity (Cex) behavior to be modelled. An analysis shows the presence of an electronic heat-capacity contribution (Cel - Schottky anomaly) around 17 K that is superimposed on a larger magnetic heat-capacity effect (Cmag

  12. Portevin-Le chatelier effect

    PubMed

    Franklin; Mertens; Marder

    2000-12-01

    Aluminum subjected to smooth mechanical loading does not often deform in a correspondingly smooth manner. Typically it deforms inhomogeneously through the propagation of deformation fronts that slowly traverse the sample. These are called Portevin-Le Chatelier fronts; what determines their velocity has been somewhat mysterious. We present a phenomenological theory for deformation fronts that centers on a nonlocal rate dependence of the flow stress. In a one-dimensional idealization the equations can be solved exactly, and compared directly with experiment. Many significant features of deformation fronts are captured, including a well-known transition from hopping to continuous front motion. The phenomenology's predictions are confirmed by our experiments. PMID:11138118

  13. Refractive-index-based calorimetric studies of RNAse T1 unfolding in small volumes using microinterferometric backscatter

    NASA Astrophysics Data System (ADS)

    Houlne, Michael P.; Hubbard, Darren S.; Makhatadze, George I.; Bornhop, Darryl J.

    1997-05-01

    Micro-interferometry, a novel technique developed by the authors, employs a linearly polarized laser, a fused silica capillary tube housing for the sample and a charged coupled device as a detector. A back scattered interference pattern, observed as a high contrast fringes, is produced when the laser is directed onto the capillary containing the sample. The positional change of the fringe pattern is a function of the refractive index of the media in the capillary. In the present work, the RNA enzyme RNase T1 is heated in the sample cell over a temperature range of 30 degrees C to 60 degrees C. Over this temperature range the molecule unfolds form the quaternary to the tertiary structure. This structure change is manifested as a refractive index change and is observed by monitoring the fringe position while ramping the cell temperature in a controlled fashion. From the refractive index response over the temperature range, the Gibbs free energy associated with unfolding is calculated. The authors show milli-degree temperature stability with a 0.1 micro-liter probe volume, thus demonstrating the application of this device in micro- calorimetric investigations.

  14. Calorimetric Low-Temperature Detectors for X-Ray Spectroscopy on Trapped Highly-Charged Heavy Ions

    NASA Technical Reports Server (NTRS)

    Kilbourne, Caroline; Kraft-Bermuth, S.; Andrianov, V.; Bleile, A.; Echler, A.; Egelhof, P.; Ilieva, S.; Kilbourne, C.; McCammon, D.

    2012-01-01

    The application of Calorimetric Low-Temperature Detectors (CLTDs) has been proposed at the Heavy-Ion TRAP facility HITRAP which is currently being installed at the Helmholtz Research Center for Heavy Ion Research GSI. This cold ion trap setup will allow the investigation of X-rays from ions practically at rest, for which the excellent energy resolution of CLTDs can be used to its full advantage. However, the relatively low intensities at HITRAP demand larger solid angles and an optimized cryogenic setup. The influence of external magnetic fields has to be taken into account. CLTDs will also be a substantial part of the instrumental equipment at the future Facility for Antiproton and Heavy Ion Research (FAIR), for which a wide variety of high-precision X-ray spectroscopy experiments has been proposed. This contribution will give an overview on the chances and challenges for the application of CLTDs at HITRAP as well as perspectives for future experiments at the FAIR facility.

  15. Surfactants induced release of a red emitting dye from the nanocavity of a molecular container: A spectroscopic and calorimetric study.

    PubMed

    Ahmed, Sayeed Ashique; Chatterjee, Aninda; Maity, Banibrata; Seth, Debabrata

    2016-08-01

    Supramolecular interaction of a red emitting dye Nile blue A (NBA) with Cucurbit[7]uril (CB7) in aqueous solution was studied and the release of the dye from the hydrophobic cavity of CB7 was reported. To investigate the supramolecular host-guest complex formation and release of dye, we have used the steady state absorption, fluorescence and time resolved fluorescence emission spectroscopy, (1)H NMR spectroscopy and isothermal titration calorimetry (ITC). The spectral properties of NBA were changed in the presence of CB7. The change in spectral features of NBA in presence of CB7 indicates the formation of supramolecular host-guest complexes. By using the SED equation the diameter of the complex was estimated. The complex formation further affirmed by the (1)H NMR study. Upfield and downfield shifts of the protons of NBA was observed in both the aliphatic and aromatic region. From the ITC measurement, we have drawn up the forces involved for the complexation of NBA with CB7. We have studied the release of NBA from the hydrophobic cavity of CB7 by using ionic, neutral surfactants and ionic liquid with the help of spectroscopic and calorimetric techniques. It is observed that on addition of SDS and ionic liquid (

  16. Calorimetric study of the superconducting and normal state properties of Ca(Fe1-xCox)2As2

    NASA Astrophysics Data System (ADS)

    Abdel-Hafiez, M.; Harnagea, L.; Singh, S.; Stockert, U.; Wurmehl, S.; Leps, N.; Klingeler, R.; Wolter, A. U. B.; Büchner, B.

    2012-12-01

    We present a calorimetric study on single crystals of Ca(Fe1-xCox)2As2 (x = 0, 0.032, 0.051, 0.056, 0.063, and 0.146). The combined first order spin-density wave/structural transition occurs in the parent CaFe2As2 compound at 168 K and gradually shifts to lower temperature for low doping levels (x = 0.032 and x = 0.051). It is completely suppressed upon higher doping x >= 0.056. Simultaneously, superconductivity appears at lower temperature with a transition temperature around Tc ~ 14.1 K for Ca(Fe0.937Co0.063)2As2. The phase diagram of Ca(Fe0.937Co0.063)2As2 has been derived and the upper critical field is found to be μ0H(c)2 = 11.5 T and μ0H(ab)c2 = 19.4 T for the c and ab directions, respectively.

  17. Kinetic and calorimetric study of the adsorption of dyes on mesoporous activated carbon prepared from coconut coir dust.

    PubMed

    Macedo, Jeremias de Souza; da Costa Júnior, Nivan Bezerra; Almeida, Luis Eduardo; Vieira, Eunice Fragoso da Silva; Cestari, Antonio Reinaldo; Gimenez, Iara de Fátima; Villarreal Carreño, Neftali Lênin; Barreto, Ledjane Silva

    2006-06-15

    Mesoporous activated carbon has been prepared from coconut coir dust as support for adsorption of some model dye molecules from aqueous solutions. The methylene blue (MB) and remazol yellow (RY) molecules were chosen for study of the adsorption capacity of cationic and anionic dyes onto prepared activated carbon. The adsorption kinetics was studied with the Lagergren first- and pseudo-second-order kinetic models as well as the intraparticle diffusion model. The results for both dyes suggested a multimechanism sorption process. The adsorption mechanisms in the systems dyes/AC follow pseudo-second-order kinetics with a significant contribution of intraparticle diffusion. The samples simultaneously present acidic and basic sites able to act as anchoring sites for basic and acidic dyes, respectively. Calorimetric studies reveal that dyes/AC interaction forces are correlated with the pH of the solution, which can be related to the charge distribution on the AC surface. These AC samples also exhibited very short equilibrium times for the adsorption of both dyes, which is an economically favorable requisite for the activated carbon described in this work, in addition to the local abundance of the raw material. PMID:16497318

  18. Spectroscopic and calorimetric investigations on the binding of phenazinium dyes safranine-O and phenosafranine to double stranded RNA polynucleotides.

    PubMed

    Saha, Baishakhi; Kumar, Gopinatha Suresh

    2016-08-01

    RNA targeting through small molecules that can selectively bind specific RNA structures is an important current strategy in therapeutic drug development. Towards this strategy a comparative study on the interaction of two phenazinium dyes, safranine-O and phenosafranine to double stranded RNAs, poly(I).poly(C), poly(A).poly(U) and poly(C).poly(G) was performed. Spectrophotometric and spectrofluorimetric studies revealed non-cooperative binding of the dyes to the duplex RNA with binding constants of the order 10(5)M(-1) with a higher affinity of safranine-O to poly(I).poly(C) followed by poly(A).poly(U) and poly(C).poly(G). Anisotropy and fluorescence quenching results confirmed an intercalation mode of binding for the dyes on these RNAs. Binding induced conformational changes in the RNA polynucleotides were revealed from circular dichroism data. Thermal melting study and DSC experiments demonstrated stabilization of dye-RNA complexes. Calorimetric studies revealed that the binding was accompanied by a large positive entropy term with a small negative enthalpy contributions. Significant hydrophobic forces in the complexation of the double stranded RNAs with the dyes were confirmed from the negative heat capacity changes. Enthalpy-entropy compensation was also observed in the binding. Parsing of the Gibbs energy suggested a larger non-electrostatic contribution in all the cases. The results presented here may be helpful to design new types of RNA-based therapeutic agents. PMID:27236048

  19. Calorimetric AC loss measurement of MgB2 superconducting tape in an alternating transport current and direct magnetic field

    NASA Astrophysics Data System (ADS)

    See, K. W.; Xu, X.; Horvat, J.; Cook, C. D.; Dou, S. X.

    2012-11-01

    Applications of MgB2 superconductors in electrical engineering have been widely reported, and various studies have been made to define their alternating current (AC) losses. However, studies on the transport losses with an applied transverse DC magnetic field have not been conducted, even though this is one of the favored conditions in applications of practical MgB2 tapes. Methods and techniques used to characterize and measure these losses have so far been grouped into ‘electrical’ and ‘calorimetric’ approaches with external conditions set to resemble the application conditions. In this paper, we present a new approach to mounting the sample and employ the calorimetric method to accurately determine the losses in the concurrent application of AC transport current and DC magnetic fields that are likely to be experienced in practical devices such as generators and motors. This technique provides great simplification compared to the pickup coil and lock-in amplifier methods and is applied to a long length (˜10 cm) superconducting tape. The AC loss data at 20 and 30 K will be presented in an applied transport current of 50 Hz under external DC magnetic fields. The results are found to be higher than the theoretical predictions because of the metallic fraction of the tape that contributes quite significantly to the total losses. The data, however, will allow minimization of losses in practical MgB2 coils and will be used in the verification of numerical coil models.

  20. pH-tuneable binding of 2′-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study

    SciTech Connect

    Ciulli, Alessio; Lobley, Carina M. C.; Tuck, Kellie L.; Smith, Alison G.; Blundell, Tom L.; Abell, Chris

    2007-02-01

    A combined crystallographic, calorimetric and mutagenic study has been used to show how changes in pH give rise to two distinct binding modes of 2′-phospho-ADP-ribose to ketopantoate reductase. The crystal structure of Escherichia coli ketopantoate reductase in complex with 2′-monophosphoadenosine 5′-diphosphoribose, a fragment of NADP{sup +} that lacks the nicotinamide ring, is reported. The ligand is bound at the enzyme active site in the opposite orientation to that observed for NADP{sup +}, with the adenine ring occupying the lipophilic nicotinamide pocket. Isothermal titration calorimetry with R31A and N98A mutants of the enzyme is used to show that the unusual ‘reversed binding mode’ observed in the crystal is triggered by changes in the protonation of binding groups at low pH. This research has important implications for fragment-based approaches to drug design, namely that the crystallization conditions and the chemical modification of ligands can have unexpected effects on the binding modes.

  1. Determination of Nuclear Charge Distributions of Fission Fragments from ^{235} U (n_th , f) with Calorimetric Low Temperature Detectors

    NASA Astrophysics Data System (ADS)

    Grabitz, P.; Andrianov, V.; Bishop, S.; Blanc, A.; Dubey, S.; Echler, A.; Egelhof, P.; Faust, H.; Gönnenwein, F.; Gomez-Guzman, J. M.; Köster, U.; Kraft-Bermuth, S.; Mutterer, M.; Scholz, P.; Stolte, S.

    2016-03-01

    Calorimetric low temperature detectors (CLTD's) for heavy-ion detection have been combined with the LOHENGRIN recoil separator at the ILL Grenoble for the determination of nuclear charge distributions of fission fragments produced by thermal neutron-induced fission of ^{235} U. The LOHENGRIN spectrometer separates fission fragments according to their mass-to-ionic-charge ratio and their kinetic energy, but has no selectivity with respect to nuclear charges Z. For the separation of the nuclear charges, one can exploit the nuclear charge-dependent energy loss of the fragments passing through an energy degrader foil (absorber method). This separation requires detector systems with high energy resolution and negligible pulse height defect, as well as degrader foils which are optimized with respect to thickness, homogeneity, and energy loss straggling. In the present, contribution results of test measurements at the Maier Leibnitz tandem accelerator facility in Munich with ^{109} Ag and ^{127} I beams with the aim to determine the most suitable degrader material, as well as measurements at the Institut Laue-Langevin will be presented. These include a systematic study of the quality of Z-separation of fission fragments in the mass range 82≤ A ≤ 132 and a systematic measurement of ^{92} Rb fission yields, as well as investigations of fission yields toward the symmetry region.

  2. Design and performance tests of the calorimetric tract of a Compton Camera for small-animals imaging

    NASA Astrophysics Data System (ADS)

    Rossi, P.; Baldazzi, G.; Battistella, A.; Bello, M.; Bollini, D.; Bonvicini, V.; Fontana, C. L.; Gennaro, G.; Moschini, G.; Navarria, F.; Rashevsky, A.; Uzunov, N.; Zampa, G.; Zampa, N.; Vacchi, A.

    2011-02-01

    The bio-distribution and targeting capability of pharmaceuticals may be assessed in small animals by imaging gamma-rays emitted from radio-isotope markers. Detectors that exploit the Compton concept allow higher gamma-ray efficiency compared to conventional Anger cameras employing collimators, and feature sub-millimeter spatial resolution and compact geometry. We are developing a Compton Camera that has to address several requirements: the high rates typical of the Compton concept; detection of gamma-rays of different energies that may range from 140 keV ( 99 mTc) to 511 keV ( β+ emitters); presence of gamma and beta radiation with energies up to 2 MeV in case of 188Re. The camera consists of a thin position-sensitive Tracker that scatters the gamma ray, and a second position-sensitive detection system to totally absorb the energy of the scattered photons (Calorimeter). In this paper we present the design and discuss the realization of the calorimetric tract, including the choice of scintillator crystal, pixel size, and detector geometry. Simulations of the gamma-ray trajectories from source to detectors have helped to assess the accuracy of the system and decide on camera design. Crystals of different materials, such as LaBr 3 GSO and YAP, and of different size, in continuous or segmented geometry, have been optically coupled to a multi-anode Hamamatsu H8500 detector, allowing measurements of spatial resolution and efficiency.

  3. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2008-09-01

    Fragmentation et astéroïdes binaires; Astéroïde géocroiseur triple; Rosetta sort de son hibernation; Messenger; Transit lunaire vu par Deep Impact; Titan; Phobos; Phoenix; Einstein avait raison; Le ballet des taches rouges; Le poids des lentilles;

  4. Le syndrome d'apert

    PubMed Central

    Benmiloud, Sarra; Chaouki, Sana; Atmani, Samir; Hida, Moustapha

    2013-01-01

    Le syndrome d'Apert est une affection congénitale rare, caractérisée par une sténose cranio-faciale associée à une syndactylie des mains et des pieds. Sa prise en charge doit être précoce et multidisciplinaire. Sa gravité réside dans la coexistence de plusieurs malformations avec un risque d'hypertension intracrânienne chronique responsable d'une cécité et d'une débilité mentale. Les auteurs rapportent une nouvelle observation à travers laquelle ils illustrent les aspects cliniques et évolutifs ainsi que les difficultés thérapeutiques de cette affection. PMID:23565313

  5. Intraday LeBaron effects

    PubMed Central

    Bianco, Simone; Corsi, Fulvio; Renò, Roberto

    2009-01-01

    We study the relation at intraday level between serial correlation and volatility of the Standard and Poor (S&P) 500 stock index futures returns. At daily and weekly levels, serial correlation and volatility forecasts have been found to be negatively correlated (LeBaron effect). After finding a significant attenuation of the original effect over time, we show that a similar but more pronounced effect holds by using intraday measures, by such as realized volatility and variance ratio. We also test the impact of unexpected volatility, defined as the part of volatility which cannot be forecasted, on the presence of intraday serial correlation in the time series by employing a model for realized volatility based on the heterogeneous market hypothesis. We find that intraday serial correlation is negatively correlated to volatility forecasts, whereas it is positively correlated to unexpected volatility.

  6. Thermogravimetric, Calorimetric, and Structural Studies of the Co3 O4 /CoO Oxidation/Reduction Reaction

    NASA Astrophysics Data System (ADS)

    Unruh, Karl; Cichocki, Ronald; Kelly, Brian; Poirier, Gerald

    2015-03-01

    To better assess the potential of cobalt oxide for thermal energy storage (TES), the Co3O4/CoO oxidation/reduction reaction has been studied by thermogravimetric (TGA), calorimetric (DSC), and x-ray diffraction (XRD) measurements in N2 and atmospheric air environments. TGA measurements showed an abrupt mass loss of about 6.6% in both N2 and air, consistent with the stoichiometric reduction of Co3O4 to CoO and structural measurements. The onset temperature of the reduction of Co3O4 in air was only weakly dependent on the sample heating rate and occurred at about 910 °C. The onset temperature for the oxidation of CoO varied between about 850 and 875 °C for cooling rates between 1 and 20 °C/min, but complete re-conversion to Co3O4 could only be achieved at the slowest cooling rates. Due to the dependence of the rate constant on the oxygen partial pressure, the oxidation of Co3O4 in a N2 environment occurred at temperatures between about 775 and 825 °C for heating rates between 1 and 20 °C/min and no subsequent re-oxidation of the reduced Co3O4 was observed on cooling to room temperature. In conjunction with a measured transition heat of about 600 J/g of Co3O4, these measurements indicate that cobalt oxide is a viable TES material.

  7. Spectroscopic and calorimetric studies on the binding of an indoloquinoline drug to parallel and antiparallel DNA triplexes.

    PubMed

    Riechert-Krause, Fanny; Autenrieth, Karolin; Eick, Andrea; Weisz, Klaus

    2013-01-01

    11-Phenyl-substituted indoloquinolines have been found to exhibit significant antiproliferative potency in cancer cells but to show only moderate affinity toward genomic double-helical DNA. In this study, parallel as well as antiparallel triple-helical DNA targets are employed to evaluate the triplex binding of these ligands. UV melting experiments with parallel triplexes indicate considerable interactions with the drug and a strong preference for TAT-rich triplexes in line with an increasing number of potential intercalation sites of similar binding strength between two TAT base triads. Via substitution of a singly charged aminoethylamine side chain by a longer and doubly charged bis(aminopropyl)amine substituent at the ligand, binding affinities increase and also start to exhibit long-range effects as indicated by a strong correlation between the binding affinity and the overall length of the TAT tract within the triplex stem. Compared to parallel triplexes, an antiparallel triplex with a GT-containing third strand constitutes a preferred target for the indoloquinoline drug. On the basis of pH-dependent titration experiments and corroborated by a Job analysis of continuous variation, binding of the drug to the GT triplex not only is strongly enhanced when the solution pH is lowered from 7 to 5 but also reveals a pH-dependent stoichiometry upon formation of the complex. Calorimetric data demonstrate that stronger binding of a protonated drug at acidic pH is associated with a more exothermic binding process. However, at pH 7 and 5, binding is enthalpically driven with additional favorable entropic contributions. PMID:23234257

  8. Calorimetric and spectroscopic studies on solvation energetics for H2 storage in the CO2/HCOOH system.

    PubMed

    Fink, Cornel; Katsyuba, Sergey; Laurenczy, Gabor

    2016-04-20

    Solvents playing a crucial role in many chemical reactions and additives can be used to shift the reaction equilibrium. Herein we study the enthalpy of mixing for selected solvents (aqueous, organic) and basic additives (amines, aqueous KOH) when mixed with formic acid with the aim to optimize hydrogen storage/delivery in the CO2/HCOOH system. Formic acid, resulting from carbon dioxide hydrogenation, reaches highest yields when effectively "removed" from the reaction equilibrium. In terms of energy efficiency, any heat released during CO2 hydrogenation has to be reused in the reverse reaction, during the production of hydrogen. In any scenario, the usage of basic chemicals, non-innocent solvents, causes higher energy release in CO2 hydrogenation, which has to be reused in the hydrogen delivery process. Therefore, the enthalpy of mixing is a valuable parameter for designing hydrogen storage devices since it allows the estimation of energy balance for the CO2 hydrogenation/H2 liberation cycle. The highest formic acid concentrations in direct catalytic CO2 hydrogenation under acidic conditions were reached in DMSO. DMSO exhibits considerably stronger interactions with formic acid compared to water as was observed in calorimetric measurements. This difference can be ascribed, at least partly, to stronger hydrogen bonding of FA to DMSO than to water in the corresponding solutions, examined by a combination of IR spectroscopic and quantum chemical studies. Furthermore, the investigation of DMSO/FA- and water/FA systems by (1)H- and (13)C-NMR spectroscopy revealed that only 1 : 1 aggregates are formed in the DMSO solutions of FA in a broad concentration range, while the stoichiometry and the number of the FA-water aggregates essentially depend on the concentration of aqueous solutions. PMID:26890151

  9. Calorimetric investigation of triazole-bridged Fe(II) spin-crossover one-dimensional materials: measuring the cooperativity.

    PubMed

    Roubeau, Olivier; Castro, Miguel; Burriel, Ramón; Haasnoot, Jaap G; Reedijk, Jan

    2011-03-31

    The relevance of abrupt magnetic and optical transitions exhibiting bistability in spin-crossover solids has been pointed out for their potential applications in optical or memory devices. In this respect, triazole-based one-dimensional coordination polymers are widely recognized as one of the most interesting systems. The measure of the interaction among spin-crossover centers at the origin of such cooperative behavior is of paramount importance and has so far been realized through modeling of spin-crossover curves derived mostly from magnetic measurements. Here, a new series of triazole-based one-dimensional coordination polymers of formula [Fe(Rtrz)(3)](A)(2)·xH(2)O with R = methoxyethyl and A = monovalent anion has been prepared that show complete and abrupt spin-crossover phenomenon as shown by magnetic measurements. The spin-crossover transition in these and related compounds is studied by differential scanning calorimetry, and the thermodynamic excess enthalpies and entropies associated with the phenomenon are derived systematically. Then the cooperative character of the spin-crossover in these materials is quantified by use of two widely used models, so-called Slichter and Drickamer and domain models. The same procedure is applied to spin-crossover curves of similar compounds available in the literature and for which calorimetric studies have been reported. The experimental thermodynamic figures, in particular the excess enthalpies, are shown to be clearly correlated to the output parameters of both models, thus providing a direct, experimental, quantitative measure of the cooperative character of the spin-crossover phenomenon. PMID:21381636

  10. Exploring the comparative binding aspects of benzophenanthridine plant alkaloid chelerythrine with RNA triple and double helices: a spectroscopic and calorimetric approach.

    PubMed

    Haque, Lucy; Pradhan, Ankur Bikash; Bhuiya, Sutanwi; Das, Suman

    2015-07-14

    A comparative study on the interaction of a benzophenanthridine alkaloid chelerythrine (CHL) with RNA triplex poly(U).poly(A)*poly(U) (hereafter U.A*U, .(dot) and *(asterisk) represent Watson-Crick and Hoogsteen base pairing respectively) and its parent duplex poly(A).poly(U) (A.U) was carried out by using a combination of various spectroscopic, viscometric and calorimetric techniques. The interaction was characterized by hypochromic and bathochromic effects in the absorption spectrum, the increase of thermal melting temperature, enhancement in solution viscosity, and perturbation in the circular dichroic spectrum. The binding constant calculated by using spectrophotometric data was in the order of 10(5) for both forms of RNA, but it was greater for triplex RNA (30.2 × 10(5) M(-1)) than duplex RNA (3.6 × 10(5) M(-1)). Isothermal titration calorimetric data are in good agreement with the spectrophotometric data. The data indicated stronger binding of CHL to the triplex structure of RNA compared to the native duplex structure. Thermal melting studies indicated greater stabilization of the Hoogsteen base paired third strand of the RNA triplex compared to its Watson-Crick strands. The mode of binding of CHL to both U.A*U and A.U was intercalation as revealed from fluorescence quenching, viscosity measurements and sensitization of the fluorescence experiment. Thermodynamic data obtained from isothermal calorimetric measurements revealed that association was favoured by both a negative enthalpy change and a positive entropy change. Taken together, our results suggest that chelerythrine binds and stabilizes the RNA triplex more strongly than its respective parent duplex. The results presented here may be useful for formulating effective antigene strategies involving benzophenanthridine alkaloids and the RNA triplex. PMID:26073991

  11. LeSTIG1, an extracellular binding partner for the pollen receptor kinases LePRK1 and LePRK2, promotes pollen tube growth in vitro.

    PubMed

    Tang, Weihua; Kelley, Dior; Ezcurra, Inés; Cotter, Robyn; McCormick, Sheila

    2004-08-01

    As pollen tubes grow through the pistil they are thought to perceive and respond to diverse signals. The tomato pollen-specific receptor kinases LePRK1 and LePRK2 might participate in signaling during pollen tube growth. We previously showed that the extracellular domain of LePRK2 interacts with a pollen protein, LAT52, before but not after pollen germination. To determine whether LePRK2 might have different binding partner(s) after pollen germination, we characterized two more proteins that, like LAT52, were identified in yeast two-hybrid screens using the extracellular domains of LePRK1 and LePRK2 as baits. We show that LeSHY, a leucine-rich repeat protein from pollen, and LeSTIG1, a small cysteine-rich protein from pistil, can bind the extracellular domains of both LePRK1 and LePRK2 in vitro. In vitro binding assays with the extracellular domain of LePRK2 suggested that LeSTIG1 could displace binding of LAT52, consistent with the idea that LePRK1 and LePRK2 might interact with different ligands at different stages of pollen tube growth. Exogenous LeSTIG1 promotes pollen tube growth in vitro. The interaction of these pollen kinases with LeSTIG1 supports the notion that LePRK1 and LePRK2 are involved in mediating pollen-pistil interactions. PMID:15255864

  12. Jan Potocki et le "Gothic Novel"

    ERIC Educational Resources Information Center

    Finne, Jacques

    1970-01-01

    Establishes a parallel between the supernatural and fantastic qualities of Le Comte Jan Potocki's literary works, and the English gothic novels by comparing the elements of terror, mysterious atmosphere, and the supernatural beings involved. (DS)

  13. Trophic relay and prey switching - A stomach contents and calorimetric investigation of an ambassid fish and their saltmarsh prey

    NASA Astrophysics Data System (ADS)

    McPhee, Jack J.; Platell, Margaret E.; Schreider, Maria J.

    2015-12-01

    Trophic relay is an ecological model that involves the movement of biomass and energy from vegetation, such as saltmarshes, within estuaries to the open sea via a series of predator-prey relationships. Any potential for trophic relay is therefore affected by water movements within an estuary and by the ability of a predator to "switch" prey in response to fluctuating abundances of those prey. Saltmarsh-dwelling grapsid crabs, which feed on saltmarsh-derived detritus and microphytobenthos, release zoeae into ebbing tides that inundate saltmarshes during spring-tide cycles within tidally-dominated estuaries, such as Brisbane Water Estuary, therefore providing an opportunity to examine whether prey-switching and/or trophic relay may occur in fish that feed on those zoeae (such as the highly abundant estuarine ambassid, Ambassis jacksoniensis). This model was examined by sampling A. jacksoniensis near saltmarshes in a large, temperate south-eastern Australian estuary during flood and ebb tides on days of saltmarsh inundation and non-inundation over four spring-tide events in 2012. Stomach fullnesses of A. jacksoniensis were generally highest during ebb tides on days of saltmarsh inundation, implying that feeding was most marked at these times. Caridean decapods dominated diets during flood tides and on days of no saltmarsh inundation, while crab zoeae dominated diets during ebb tides and on days of inundation, suggesting that, when saltmarsh-derived zoeae became abundant, A. jacksoniensis switched to feeding on those prey. Three potential zooplankton prey (calanoid copepods, caridean decapods and crab zoeae) did not differ calorimetrically, indicating that switching of prey by A. jacksoniensis is not directly related to their preying on energetically greater prey, but reflects opportunistic feeding on more abundant and/or less elusive prey. As A. jacksoniensis is able to switch prey from estuarine caridean decapods to saltmarsh-derived crab zoeae, this very abundant

  14. Calorimetric and acoustic emission study of martensitic transformation in single-crystalline Ni2MnGa alloys

    NASA Astrophysics Data System (ADS)

    Tóth, László Z.; Szabó, Sándor; Daróczi, Lajos; Beke, Dezső L.

    2014-12-01

    The jerky character of austenite-martensite phase transformation in Ni2MnGa single crystals (with 10M martensite structure) has been investigated by thermal cycling using a differential scanning calorimeter (DSC) and by detection of acoustic emissions (AEs) at low cooling and heating rates (0.1 K/min and below). It is illustrated that, besides the low cooling and heating rate, mass and surface roughness are also important parameters in optimizing the best signal/noise ratio in order to obtain individual peaks suitable for statistical analysis. Three types of samples, differing in the twin structure and twin boundary behavior, were investigated with and without surface roughening made by electro-erosion. The statistical analysis, carried out for both (thermal and acoustic) types of signals, provided power-law behavior. In calorimetric measurements the energy exponents, obtained in cooling, were the same within the experimental errors (ɛ =1.7 ±0.2 ) for the three samples investigated. In acoustic emission experiments the energy and amplitude, α , exponents were determined both for cooling and heating. The exponents for cooling and heating runs are slightly different. They are larger for heating for both α and ɛ , in accordance with the asymmetric acoustic activity: we observed higher acoustic activity (higher number of hits) during cooling. The effect of the surface roughness is negligible in the exponents (but higher acoustic activity corresponds to higher roughness) and the following values were obtained: ɛ =1.5 ±0.1 and α =2.1 ±0.1 for cooling as well as ɛ =1.8 ±0.1 and α =2.6 ±0.1 for heating. Our results are in accordance with the results of Gallardo et al. [Phys. Rev. B 81, 174102 (2010), 10.1103/PhysRevB.81.174102] obtained in Cu based alloys: the exponents of the energy distributions, for both DSC and AE signals, were the same within the experimental errors. Furthermore, our exponents obtained from the AE measurements are close to the values

  15. Micromechanical calorimetric sensor

    DOEpatents

    Thundat, Thomas G.; Doktycz, Mitchel J.

    2000-01-01

    A calorimeter sensor apparatus is developed utilizing microcantilevered spring elements for detecting thermal changes within a sample containing biomolecules which undergo chemical and biochemical reactions. The spring element includes a bimaterial layer of chemicals on a coated region on at least one surface of the microcantilever. The chemicals generate a differential thermal stress across the surface upon reaction of the chemicals with an analyte or biomolecules within the sample due to the heat of chemical reactions in the sample placed on the coated region. The thermal stress across the spring element surface creates mechanical bending of the microcantilever. The spring element has a low thermal mass to allow detection and measuring of heat transfers associated with chemical and biochemical reactions within a sample placed on or near the coated region. A second surface may have a different material, or the second surface and body of microcantilever may be of an inert composition. The differential thermal stress between the surfaces of the microcantilever create bending of the cantilever. Deflections of the cantilever are detected by a variety of detection techniques. The microcantilever may be approximately 1 to 200 .mu.m long, approximately 1 to 50 .mu.m wide, and approximately 0.3 to 3.0 .mu.m thick. A sensitivity for detection of deflections is in the range of 0.01 nanometers. The microcantilever is extremely sensitive to thermal changes in samples as small as 30 microliters.

  16. Calorimetric system and method

    DOEpatents

    Gschneidner, K.A. Jr.; Pecharsky, V.K.; Moorman, J.O.

    1998-09-15

    Apparatus is described for measuring heat capacity of a sample where a series of measurements are taken in succession comprises a sample holder in which a sample to be measured is disposed, a temperature sensor and sample heater for providing a heat pulse thermally connected to the sample, and an adiabatic heat shield in which the sample holder is positioned and including an electrical heater. An electrical power supply device provides an electrical power output to the sample heater to generate a heat pulse. The electrical power from a power source to the heat shield heater is adjusted by a control device, if necessary, from one measurement to the next in response to a sample temperature-versus-time change determined before and after a previous heat pulse to provide a subsequent sample temperature-versus-time change that is substantially linear before and after the subsequent heat pulse. A temperature sensor is used and operable over a range of temperatures ranging from approximately 3K to 350K depending upon the refrigerant used. The sample optionally can be subjected to dc magnetic fields such as from 0 to 12 Tesla (0 to 120 kOe). 18 figs.

  17. Calorimetric system and method

    DOEpatents

    Gschneidner, Jr., Karl A.; Pecharsky, Vitalij K.; Moorman, Jack O.

    1998-09-15

    Apparatus for measuring heat capacity of a sample where a series of measurements are taken in succession comprises a sample holder in which a sample to be measured is disposed, a temperature sensor and sample heater for providing a heat pulse thermally connected to the sample, and an adiabatic heat shield in which the sample holder is positioned and including an electrical heater. An electrical power supply device provides an electrical power output to the sample heater to generate a heat pulse. The electrical power from a power source to the heat shield heater is adjusted by a control device, if necessary, from one measurement to the next in response to a sample temperature-versus-time change determined before and after a previous heat pulse to provide a subsequent sample temperature-versus-time change that is substantially linear before and after the subsequent heat pulse. A temperature sensor is used and operable over a range of temperatures ranging from approximately 3K to 350K depending upon the refrigerant used. The sample optionally can be subjected to dc magnetic fields such as from 0 to 12 Tesla (0 to 120 kOe).

  18. Entrevue avec le Dr Charley Zeanah

    PubMed Central

    2013-01-01

    Le Dr Charles Zeanah est titulaire de la chaire de psychiatrie Mary K. Sellars-Polchow, professeur de pédiatrie clinique et vice-président de la pédopsychiatrie au département de psychiatrie et des sciences du comportement de la faculté de médecine de l’Université Tulane, à la Nouvelle-Orléans. Il est également directeur général de l’institut de la santé mentale des nourrissons et des jeunes enfants de Tulane. Il est récipiendaire de nombreux prix, notamment le prix de prévention Irving Phillips (AACAP), la mention élogieuse présidentielle pour sa recherche et son leadership exceptionnels en santé mentale des nourrissons (American Orthopsychiatric Association), le prix d’excellence clinique Sarah Haley Memorial (International Society for Traumatic Stress Studies), le prix de recherche en pédopsychiatrie Blanche F. Ittelson (APA), et le prix Serge Lebovici Award soulignant les contributions internationales à la santé mentale des nourrissons (World Association for Infant Mental Health). Le Dr Zeanah est fellow distingué de l’AACAP, fellow distingué de l’APA et membre du conseil d’administration de Zero to Three. Il est l’éditeur scientifique de Handbook of Infant Mental Health (3e édition) qui est considéré comme étant le manuel de pointe et la référence de base du domaine de la santé mentale des nourrissons.

  19. Calorimetric Study of Phase Stability and Phase Transformation in U- xZr ( x = 2, 5, 10 wt pct) Alloys

    NASA Astrophysics Data System (ADS)

    Rai, Arun Kumar; Subramanian, Raju; Hajra, Raj Narayan; Tripathy, Haraprasanna; Rengachari, Mythili; Saibaba, Saroja

    2015-11-01

    A comprehensive calorimetric study of high-temperature phase equilibria and phase transformation characteristics in U- xZr ( x = 2, 5, 10 wt pct) alloys has been undertaken, as a function of heating and cooling rates. It is found that the following sequence of phase transformation takes place upon slow heating in annealed U-2 wt pct Zr alloy: α + α' + δ-UZr2 → α + γ 2 → β + γ 2 → β + γ 1 → γ. For alloys of 5 and 10 wt pct Zr, the additional presence of a miscibility gap ( γ 1 U-rich bcc + γ 2 Zr-rich bcc) in the high-temperature γ(bcc) phase region resulted in the following transformation sequence: α + α' + δ-UZr2 → α + γ 2 → β + γ 2 → γ 1 + γ 2 → γ. Further, it has been demonstrated that depending on the nature of starting microstructure, namely whether it is α eq + δ-UZr2, or a mix of α' + α eq + δ-UZr2 phases, the relative extents of two possible co-occurring modes of the first on-heating phase transformation step differ. In case of starting microstructure having mixture of three phases α' + α eq + δ-UZr2, it is found that α'-martensite relaxation via α' + α eq + δ-UZr2 → α eq + δ-UZr2 constitutes the first on-heating thermal response. The α'-martensitic relaxation is very closely followed by the dissolution of δ-UZr2. The co-occurrence of these two events gives rise to a composite thermal arrest in a normal dynamic calorimetry profile. However, if the starting microstructure is the one having the equilibrium mix of α eq and δ-UZr2, then only the peritectoidal dissolution of δ-UZr2 is found in the calorimetry profile. Unless, a very slow cooling rate of the order of 0.1 K min-1 is adopted from high-temperature γ(bcc) phase, it is not possible to obtain 100 pct of α eq phase along with equilibrium amount of δ-UZr2. At normal and high cooling rates, it is possible to suppress the diffusional decomposition of γ to varying extents. The direct γ → α'-martensite transformation has been observed at

  20. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2014-06-01

    Future lune ? - L'âge de la Lune - Des volcans actifs sur Vénus - Un lac dans le cratère Gusev ? - Météorites et atmosphère martiennes - L’hexagone de Saturne - Pluton - Exo-Terre - Bêta Pictoris b - Cérès et Vesta depuis Mars - Naine froide - Parallaxes par Hubble - L2 Puppis et le sort du Soleil - Supernova et lentille gravitationnelle - Champ magnétique galactique - L’objet de Sakurai - Fermi et la matière noire - Lentille naine

  1. A spectroscopic and calorimetric study of the melting behaviors of a "bent" and a "normal" DNA duplex: [d(GA4T4C)]2 versus [d(GT4A4C)]2.

    PubMed Central

    Park, Y W; Breslauer, K J

    1991-01-01

    We have calorimetrically detected and energetically characterized a premelting event in the "bent" duplex [d(GA4T4C)]2 that is absent in the "normal" duplex [d(GT4A4C)]2. This premelting may correspond to the thermally induced "unbending" of the duplex. Specifically, we have used a combination of spectroscopic and calorimetric techniques to evaluate whether differences in the electrophoretic and hydrogen exchange properties of the bent duplex, [d(GA4T4C)]2, and the normal duplex, [d(GT4A4C)]2, are paralleled by differences in the equilibrium melting properties of these duplexes. Our results reveal that the bimolecular global meltings of both duplexes exhibit two-state behavior and are characterized by the expected thermodynamic changes, as well as the expected salt-dependencies. Significantly, however, at temperatures below duplex melting and over a similar temperature range in which the aberrant electrophoretic mobility is observed (approximately less than 35 degrees C), the bent duplex exhibits calorimetric premelting behavior absent in the normal duplex. Analysis of the calorimetric data in this preglobal melting domain (approximately less than 35 degrees C) allows us to estimate a lower-limit value of 1.6 kcal/(mol-base pair) for the thermally induced unbending of the decameric duplex. PMID:1996356

  2. 23. VIEW OF LE CLAIRE LOCK (19211925), SHOWING OPERATING MACHINERY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. VIEW OF LE CLAIRE LOCK (1921-1925), SHOWING OPERATING MACHINERY, DOWSTREAM GATES, UPSTREAM SIDE - Mississippi River 9-Foot Channel, Lock & Dam No. 14, Upper Mississippi River, Le Claire, Scott County, IA

  3. 20. VIEW OF LE CLAIRE LOCK (19211925), SHOWING UPSTREAM GATES, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. VIEW OF LE CLAIRE LOCK (1921-1925), SHOWING UPSTREAM GATES, DOWNSTREAM SIDE AND SOUTH LOCKWALL - Mississippi River 9-Foot Channel, Lock & Dam No. 14, Upper Mississippi River, Le Claire, Scott County, IA

  4. 30. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE, LE CLAIRE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE, LE CLAIRE BASE COMPOUND, LOOKING EAST - Mississippi River 9-Foot Channel, Lock & Dam No. 14, Upper Mississippi River, Le Claire, Scott County, IA

  5. 29. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE BUILDING, LE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE BUILDING, LE CLAIRE BASE COMPOUND, LOOKING WEST - Mississippi River 9-Foot Channel, Lock & Dam No. 14, Upper Mississippi River, Le Claire, Scott County, IA

  6. Development of a new type of high pressure calorimetric cell, mechanically agitated and equipped with a dynamic pressure control system: Application to the characterization of gas hydrates

    SciTech Connect

    Plantier, F. Missima, D.; Torré, J.-P.; Marlin, L.

    2013-12-15

    A novel prototype of calorimetric cell has been developed allowing experiments under pressure with an in situ agitation system and a dynamic control of the pressure inside the cell. The use of such a system opens a wide range of potential practical applications for determining properties of complex fluids in both pressurized and agitated conditions. The technical details of this prototype and its calibration procedure are described, and an application devoted to the determination of phase equilibrium and phase change enthalpy of gas hydrates is presented. Our results, obtained with a good precision and reproducibility, were found in fairly good agreement with those found in literature, illustrate the various interests to use this novel apparatus.

  7. Calorimetric Studies of the Energetics of Order-Disorder in the System Mg(1-x)Fe(x)Ca(CO(3))(2)

    SciTech Connect

    Brady, P.; Dooley, D.; Navrotsky, A.; Reeder, R.

    1999-02-10

    Calorimetric studies by Chai and Navrotsky (1996) on dolomite-ankerite energetic have been extended by including two additional types of samples: a very disordered stoichiometric MgCa(CO{sub 3}){sub 2} prepared from low temperature aqueous solution and three largely ordered natural samples of intermediate iron content. Combining these data with previous work, three distinct trends of energetic can be seen: those for samples with nearly complete order, nearly complete disorder, and intermediate order. From these trends, the enthalpy of complete disordering is estimated to be 33 {+-} 6 kJ/mol for MgCa(CO{sub 3}){sub 2} and 18 {+-} 5 kJ/mol for FeCa(CO{sub 3}){sub 2}.

  8. A Search for Low-Mass Weakly Interacting Massive Particles Using Voltage-Assisted Calorimetric Ionization Detection in the SuperCDMS Experiment

    SciTech Connect

    Agnese, R.; Anderson, A. J.; Asai, M.; Balakishiyeva, D.; Basu Thakur, R.; Bauer, D. A.; Billard, J.; Borgland, A.; Bowles, M. A.; Brandt, D.; Brink, P. L.; Bunker, R.; Cabrera, B.; Caldwell, D. O.; Cerdeno, D. G.; Chagani, H.; Cooley, J.; Cornell, B.; Crewdson, C. H.; Cushman, Priscilla B.; Daal, M.; Di Stefano, P. C.; Doughty, T.; Esteban, L.; Fallows, S.; Figueroa-Feliciano, E.; Godfrey, G. L.; Golwala, S. R.; Hall, Jeter C.; Harris, H. R.; Hertel, S. A.; Hofer, T.; Holmgren, D.; Hsu, L.; Huber, M. E.; Jastram, A.; Kamaev, O.; Kara, B.; Kelsey, M. H.; Kennedy, A.; Kiveni, M.; Koch, K.; Loer, B.; Lopez Asamar, E.; Mahapatra, R.; Mandic, V.; Martinez, C.; McCarthy, K. A.; Mirabolfathi, N.; Moffatt, R. A.; Moore, D. C.; Nadeau, P.; Nelson, R. H.; Page, K.; Partridge, R.; Pepin, M.; Phipps, A.; Prasad, K.; Pyle, M.; Qiu, H.; Rau, W.; Redi, P.; Reisetter, A.; Ricci, Y.; Saab, T.; Sadoulet, B.; Sander, J.; Schneck, K.; Schnee, Richard; Scorza, S.; Serfass, B.; Shank, B.; Speller, D.; Villano, A. N.; Welliver, B.; Wright, D. H.; Yellin, S.; Yen, J. J.; Young, B. A.; Zhang, J.

    2014-01-27

    SuperCDMS is an experiment designed to directly detect weakly interacting massive particles (WIMPs), a favored candidate for dark matter ubiquitous in the Universe. In this Letter, we present WIMP-search results using a calorimetric technique we call CDMSlite, which relies on voltage-assisted Luke-Neganov amplification of the ionization energy deposited by particle interactions. The data were collected with a single 0.6 kg germanium detector running for ten live days at the Soudan Underground Laboratory. A low energy threshold of (electron equivalent) was obtained, which allows us to constrain new WIMP-nucleon spin-independent parameter space for WIMP masses below 6 GeV/c2.

  9. Search for Low-Mass Weakly Interacting Massive Particles Using Voltage-Assisted Calorimetric Ionization Detection in the SuperCDMS Experiment

    NASA Astrophysics Data System (ADS)

    Agnese, R.; Anderson, A. J.; Asai, M.; Balakishiyeva, D.; Basu Thakur, R.; Bauer, D. A.; Billard, J.; Borgland, A.; Bowles, M. A.; Brandt, D.; Brink, P. L.; Bunker, R.; Cabrera, B.; Caldwell, D. O.; Cerdeno, D. G.; Chagani, H.; Cooley, J.; Cornell, B.; Crewdson, C. H.; Cushman, P.; Daal, M.; Di Stefano, P. C. F.; Doughty, T.; Esteban, L.; Fallows, S.; Figueroa-Feliciano, E.; Godfrey, G. L.; Golwala, S. R.; Hall, J.; Harris, H. R.; Hertel, S. A.; Hofer, T.; Holmgren, D.; Hsu, L.; Huber, M. E.; Jastram, A.; Kamaev, O.; Kara, B.; Kelsey, M. H.; Kennedy, A.; Kiveni, M.; Koch, K.; Loer, B.; Lopez Asamar, E.; Mahapatra, R.; Mandic, V.; Martinez, C.; McCarthy, K. A.; Mirabolfathi, N.; Moffatt, R. A.; Moore, D. C.; Nadeau, P.; Nelson, R. H.; Page, K.; Partridge, R.; Pepin, M.; Phipps, A.; Prasad, K.; Pyle, M.; Qiu, H.; Rau, W.; Redl, P.; Reisetter, A.; Ricci, Y.; Saab, T.; Sadoulet, B.; Sander, J.; Schneck, K.; Schnee, R. W.; Scorza, S.; Serfass, B.; Shank, B.; Speller, D.; Villano, A. N.; Welliver, B.; Wright, D. H.; Yellin, S.; Yen, J. J.; Young, B. A.; Zhang, J.; SuperCDMS Collaboration

    2014-01-01

    SuperCDMS is an experiment designed to directly detect weakly interacting massive particles (WIMPs), a favored candidate for dark matter ubiquitous in the Universe. In this Letter, we present WIMP-search results using a calorimetric technique we call CDMSlite, which relies on voltage-assisted Luke-Neganov amplification of the ionization energy deposited by particle interactions. The data were collected with a single 0.6 kg germanium detector running for ten live days at the Soudan Underground Laboratory. A low energy threshold of 170 eVee (electron equivalent) was obtained, which allows us to constrain new WIMP-nucleon spin-independent parameter space for WIMP masses below 6 GeV /c2.

  10. Calorimetric determination of the magnetic phase diagram of underdoped ortho II YBa2Cu3O6.54 single crystals

    PubMed Central

    Marcenat, C.; Demuer, A.; Beauvois, K.; Michon, B.; Grockowiak, A.; Liang, R.; Hardy, W.; Bonn, D. A.; Klein, T.

    2015-01-01

    The recent discovery of a charge order in underdoped YBa2Cu3Oy raised the question of the interplay between superconductivity and this competing phase. Understanding the normal state of high-temperature superconductors is now an essential step towards the description of the pairing mechanism in those materials and determining the upper critical field is therefore of fundamental importance. We present here a calorimetric determination of the field–temperature phase diagram in underdoped YBa2Cu3Oy single crystals. We show that the specific heat saturates in high magnetic fields. This saturation is consistent with a normal state without any significant superconducting contribution and a total Sommerfeld coefficient γN∼6.5±1.5 mJ mol−1 K−2 putting strong constraints on the theoretical models for the Fermi surface reconstruction. PMID:26294047

  11. Le Francais Courant: Part V, French.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Instructional objectives of the Dade County Public Schools Quinmester Program in French for use with "Le Francais Courant: Part 5" focus on the development of mastery of the basic numbering system and other grammatical structures. Structures include the formation of the present tense of the irregular verbs "vouloir,""pouvoir," and "venir,"…

  12. Le Francais Moderne: Part I, French.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Instructional objectives of the Dade County Public Schools Quinmester Program in French for use with "Le Francais Moderne: Part 1" focus on the development of vocabulary and mastery of grammatical structures. The formation of the passe compose with "avoir," object pronouns, the present tense of regular "-ir" verbs, and the irregular verbs…

  13. Le Chatelier's principle in replicator dynamics

    NASA Astrophysics Data System (ADS)

    Allahverdyan, Armen E.; Galstyan, Aram

    2011-10-01

    The Le Chatelier principle states that physical equilibria are not only stable, but they also resist external perturbations via short-time negative-feedback mechanisms: a perturbation induces processes tending to diminish its results. The principle has deep roots, e.g., in thermodynamics it is closely related to the second law and the positivity of the entropy production. Here we study the applicability of the Le Chatelier principle to evolutionary game theory, i.e., to perturbations of a Nash equilibrium within the replicator dynamics. We show that the principle can be reformulated as a majorization relation. This defines a stability notion that generalizes the concept of evolutionary stability. We determine criteria for a Nash equilibrium to satisfy the Le Chatelier principle and relate them to mutualistic interactions (game-theoretical anticoordination) showing in which sense mutualistic replicators can be more stable than (say) competing ones. There are globally stable Nash equilibria, where the Le Chatelier principle is violated even locally: in contrast to the thermodynamic equilibrium a Nash equilibrium can amplify small perturbations, though both types of equilibria satisfy the detailed balance condition.

  14. Restart function of the LE-5 engine

    NASA Astrophysics Data System (ADS)

    Hirata, Kunio; Koyari, Yukio; Yanagawa, Koji; Katsuta, Hideaki; Taniguchi, Hirofumi; Torii, Yoshihiro

    1993-10-01

    This report presents the restart function of the LE-5 (Liquid Engine-5). The development of a de/anti-ice system and a sufficient pump precooling system was key in establishing this function. To ensure high reliability, a contingency device was also adopted. The functions were proved through actual flights.

  15. A Colorful Demonstration of Le Chbtelier's Principle.

    ERIC Educational Resources Information Center

    Last, Arthur M.; Slade, Peter W.

    1997-01-01

    Le Chbtelier's Principle states that, when a system at equilibrium is subjected to stress, the system will respond in such a way as to minimize the effect of the stress. Describes a lecture demonstration that illustrates shifts in the position of equilibrium caused by a variety of factors. The equilibrium mixture contains iron (III) and…

  16. Thermodynamic properties of illite, smectite and beidellite by calorimetric methods: Enthalpies of formation, heat capacities, entropies and Gibbs free energies of formation

    NASA Astrophysics Data System (ADS)

    Gailhanou, H.; Blanc, P.; Rogez, J.; Mikaelian, G.; Kawaji, H.; Olives, J.; Amouric, M.; Denoyel, R.; Bourrelly, S.; Montouillout, V.; Vieillard, P.; Fialips, C. I.; Michau, N.; Gaucher, E. C.

    2012-07-01

    The thermodynamic properties of three aluminous 2:1 clay minerals were acquired at 1.013 bars and at temperatures between 5 and 500 K using various calorimetric methods. Calorimetric measurements were performed on hydrated and dehydrated <2 μm clay fractions of smectite MX-80 (Wyoming), illite IMt-2 (Silver Hill) and beidellite SBId-1 (Black Jack Mine). After purification, the mineralogical analyses gave the following structural formulae: Na0.409K0.024Ca0.009 (Si3.738Al0.262) (Al1.598Mg0.214Fe 0.173 3 + Fe 0.035 2 +)O10(OH)2,K0.762Na0.044 (Si3.387Al0.613) (Al1.427Mg0.241Fe 0.292 3 + Fe 0.084 2 +)O10(OH)2 and Ca0.185K0.104 (Si3.574Al0.426) (Al1.812Mg0.09Fe 0.112 3 +)O10(OH)2 for smectite MX-80, illite IMt-2 and beidellite SBId-1, respectively. Heat capacities were measured by low temperature adiabatic calorimetry and differential scanning calorimetry, from 5 to 500 K. Standard enthalpies of formation were obtained from solution-reaction calorimetry at 298.15 K. The standard Gibbs free energies of formation of the clay minerals were also calculated, together with the equilibrium constants at 25 °C, for anhydrous and hydrated minerals. A comparison between these experimental data and estimated values obtained from prediction models available in the literature, enabled the calculation method that appears to be the most relevant to be selected, at least for aluminous 2:1 clay minerals.

  17. Type-1 chain histo-blood group antigens (Le(a), monosialosyl-Le(a), disialosyl-Le(a), Le(b), and H) in normal and malignant human endometrium.

    PubMed

    Ravn, V; Mandel, U; Svenstrup, B; Dabelsteen, E

    1994-01-01

    Type-1 chain histo-blood group antigens such as the Lewis (Le)a, monosialosyl-Le(a), Le(b) and H antigens show an increased expression in endometrial carcinomas. However, the possibility that these antigens are expressed under genetic or hormonal influence in endometrial carcinomas has not been considered. In the present study, the expression of type-1 chain carbohydrate antigens in normal and malignant endometrium was evaluated by immunohistochemistry and related to both genetic and hormonal factors. The glands of normal, non-secretory endometria expressed, in contrast with surface epithelial cells, Le(a), Le(b), disialosyl-Le(a), and H determinants infrequently. Adenomatous hyperplasias and endometrial carcinomas showed an increased expression of type-1 chain carbohydrates that was qualitatively influenced by the erythrocyte Lewis phenotype and the secretor status. Whereas Le(a+b-) non-secretors mainly accumulated Le(a) antigen, and only limited amounts of Le(b) antigen, Le(a-b+) secretors expressed H, Le(b) and Le(a) antigens. The expression of type-1 chain antigens showed no association with the serum-oestrogen level or to the hormone-receptor status. Thus the Lewis secretor status has a qualitative influence on the increased expression of type-1 chain antigens, which, however, seem to be unrelated to hormonal factors. Our findings suggest an increased activity of the Se-gene-defined or a closely related fucosyl-transferase in neoplastic endometrial epithelial cells. PMID:8032530

  18. Le syndrome d’alcoolisme foetal

    PubMed Central

    2002-01-01

    L’alcool est un tératogène physique et comportemental. Le syndrome d’alcoolisme foetal (SAF) est un trouble courant mais encore sous-diagnostiqué découlant de la consommation d’alcool par la mère pendant la grossesse. Bien qu’il puisse être prévenu, le SAF est également invalidant. Même si le SAF est présent dans tous les groupes socioéconomiques du Canada, sa prévalence est élevée dans certaines communautés inuites et des Premières nations du Canada. Le présent énoncé porte sur la prévention, le diagnostic, le dépistage précoce et la prise en charge du SAF par les professionnels de la santé. La prévention du SAF doit s’effectuer à deux échelons. La prévention primaire consiste à éliminer le SAF par une formation en classe ou dans la collectivité et à inciter les femmes à éviter de consommer de l’alcool avant la conception et pendant la grossesse. La prévention secondaire consiste à repérer les femmes qui boivent pendant leur grossesse et à réduire leur consommation. Le présent énoncé décrit plusieurs stratégies de dépistage, dont la stratégie T-ACE (tolérance-agacement, réduction, éveil). Les dispensateurs de soins devraient recommander l’abstinence dès la première visite prénatale. Un envoi rapide en consultation en vue de traiter l’alcoolisme est recommandé pour les femmes enceintes incapables d’arrêter de boire. Le présent énoncé décrit le diagnostic de SAF, de SAF partiel ou atypique, d’anomalies congénitales et de troubles neurodéveloppementaux reliés à l’alcool. En cas d’exposition à l’alcool in utero, un diagnostic de SAF devrait être envisagé en présence d’un retard de croissance courant ou antérieur, de certaines anomalies faciales touchant la lèvre supérieure et les yeux et d’anomalies neurodéveloppementales. Ces caractéristiques sont mieux quantifiées au moyen d’une méthode diagnostique à quatre chiffres. Des stratégies de dépistage précoce des

  19. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2013-06-01

    Une binaire remarquable; Collision de galaxies; La nébuleuse planétaire C1295; ALMA (suite); Couple massif; Astéroïdes lointains; L’eau de Jupiter; Occultation par Pluton; Super-Terres; Première image d’une planète massive autour d’une étoile double; Tempête au pôle de Saturne

  20. Les Troubles Respiratoires Chez Le Brule

    PubMed Central

    Fassi Fihri, J.; Ezzoubi, M.; Boukind, E.H.

    2010-01-01

    Summary A travers une revue de la littérature, cet article se propose d'exposer les particularités des troubles respiratoires chez le brûlé. Ces troubles sont liés à un mécanisme direct, lorsque l'arbre respiratoire est lésé par le transfert d'énergie thermique du à la brûlure et/ou par un mécanisme indirect, lorsque la fonction respiratoire et ventilatoire du poumon est perturbée par les phénomènes loco-régionaux ou généraux du brûlé. Ces troubles respiratoires sont aggravés par l'inhalation des gaz contenus dans la fumée d'incendie. Le diagnostic de ces troubles est clinique et paraclinique. Il doit être précoce et continu. Les patients nécessitent de différents moyens thérapeutiques tels que l'oxygénothérapie, la libération des voies respiratoires, l'amélioration de la mécanique ventilatoire et de la fonction respiratoire, l'antibiothérapie ou la chirurgie des séquelles. Cette prise en charge doit nécessairement être multidisciplinaire. PMID:21991224

  1. Le déficit immunitaire humoral: mieux le connaître pour mieux le prendre en charge

    PubMed Central

    El Bakkouri, Jalila; Aadam, Zahra; Ailal, Fatima; Alj, Hanane Salih; Bousfiha, Ahmed Aziz

    2014-01-01

    Les déficits immunitaires humoraux (DIH) sont des maladies hétérogènes allant des formes asymptomatiques rencontrés lors des déficits sélectifs en immunoglobulines A (IgA) et en sous-classes d'IgG aux formes graves des agammaglobulinémies congénitales. Les patients atteints de DIH présentent souvent des infections ORL ou des voies respiratoires récidivantes ou sévères. Ces patients peuvent présenter un certain nombre de complications non infectieuses, telles que des manifestations auto-immunes et des entéropathies, qui pourraient être le seul symptôme clinique révélateur. Les formes sévères des DIH sont facilement diagnostiquées grâce au dosage des IgG totaux, des IgA et des IgM. La thérapie substitutive par les immunoglobulines reste le traitement de choix chez ces patients. PMID:25489366

  2. Notable Stabilization of α-Chymotrypsin by the Protic Ionic Additive, [ch][dhp]: Calorimetric Evidence for a Fine Enthalpy/Entropy Balance

    PubMed Central

    Makharadze, Maya; van Eldik, Rudi; Khoshtariya, Dimitri E.

    2014-01-01

    An impact of 0.5 to 3 M choline dihydrogen phosphate, [ch][dhp], the biotechnologically relevant ionic substance, on the thermal stability of a model globular protein, α-chymotrypsin (α-CT), has been studied exploiting the highly sensitive differential scanning calorimetry (DSC) technique. The notable overall stabilizing effect of 11 ± 2 K regarding the thermal transition (melting) temperature, Tm, has been detected. For this kind of series, for the first time, the calorimetric melting enthalpy (ΔHcal) and transition entropy (ΔSm) parameters have been determined simultaneously throughout. The first analysis indicated a two-phase impact implying (a) the initial, dramatic drop in both ΔHcal and ΔSm, obviously connected to specific, direct interaction between the [ch][dhp] components and α-CT's charged groups (within 0 to 1 mol/L [ch][dhp]), leading to the essential rearrangement of the interfacial hydrogen-bonded (HB) network; and (b) the follow-up (within 1 to 3.0 mol/L [ch][dhp]), modest changes in ΔHcal and lack of changes in ΔSm, seemingly connected with a subsequent steady strengthening of already reformed HB network, respectively. These changes, presumably, are primarily facilitated by Coulombic interactions between the [dhp] anions and solvent-exposed positively charged amino groups of α-CT.

  3. Calorimetric study of crystal growth of ice in hydrated methemoglobin and of redistribution of the water clusters formed on melting the ice.

    PubMed Central

    Sartor, G; Mayer, E

    1994-01-01

    Calorimetric studies of the melting patterns of ice in hydrated methemoglobin powders containing between 0.43 and 0.58 (g water)/(g protein), and of their dependence on annealing at subzero temperatures and on isothermal treatment at ambient temperature are reported. Cooling rates were varied between approximately 1500 and 5 K min-1 and heating rate was 30 K min-1. Recrystallization of ice during annealing is observed at T > 228 K. The melting patterns of annealed samples are characteristically different from those of unannealed samples by the shifting of the melting temperature of the recrystallized ice fraction to higher temperatures toward the value of "bulk" ice. The "large" ice crystals formed during recrystallization melt on heating into "large" clusters of water whose redistribution and apparent equilibration is followed as a function of time and/or temperature by comparison with melting endotherms. We have also studied the effect of cooling rate on the melting pattern of ice with a methemoglobin sample containing 0.50 (g water)/(g protein), and we surmise that for this hydration cooling at rates of > or = approximately 150 K min-1 preserves on the whole the distribution of water molecules present at ambient temperature. PMID:7819504

  4. Lele de l’omalizumab dans le traitement de l’asthme allergique grave

    PubMed Central

    Chapman, Kenneth R; Cartier, André; Hébert, Jacques; McIvor, R Andrew; Schellenberg, R Robert

    2006-01-01

    CONTEXTE : Un nouveau traitement anti-immunoglobuline E (anti-IgE) contre l’asthme, l’omalizumab, a été approuvé au Canada. OBJECTIF : Passer en revue les données fondamentales et cliniques sur l’omalizumab et examiner lele possible de ce médicament dans la prise en charge de l’asthme au Canada. MÉTHODOLOGIE : Une recherche documentaire a été effectuée dans MEDLINE afin de repérer les études menées de 1960 à 2006 sur l’omalizumab. La recherche a également porté sur les résumés de réunions scientifiques récentes dans le domaine des maladies respiratoires et des allergies; par ailleurs, toute donnée non publiée a été demandée au fabricant. Après avoir revu et résumé les données, un comité mixte constitué de spécialistes des maladies respiratoires et des allergies a rédigé un ensemble de recommandations relatives à l’utilisation de l’omalizumab. RÉSULTATS : L’omalizumab est un anticorps monoclonal humanisé qui se lie au domaine C epsilon 3 de la molécule d’IgE pour former des complexes immuns solubles qui sont éliminés par le système réticulo-endothélial. L’administration d’injections sous-cutanées espacées de deux ou de quatre semaines à la dose recommandée entraîne une diminution rapide des taux d’IgE circulantes libres. Lors de deux essais cliniques de phase III menés auprès de 1 405 adultes et adolescents atteints d’asthme modéré à grave qui recevaient des doses moyennes stables de corticostéroïdes en inhalation (CSI), l’omalizumab a diminué les taux d’exacerbation par rapport au placebo et a été associé à une amélioration des symptômes ainsi qu’à une épargne plus importante des corticostéroïdes. Dans un essai mené auprès de 419 patients atteints d’asthme grave non maîtrisé malgré l’utilisation de doses élevées de CSI et de la prise concomitante d’agonistes bêta-2 à action prolongée, les exacerbations graves étaient de 50 % moins fréquentes chez

  5. Intracranial subdural hygroma after Le Fort I osteotomy.

    PubMed

    Thompson, William L; Lee, Michael; MacIntosh, Robert Bruce

    2015-04-01

    Various intra- and postoperative complications have been well-documented after Le Fort I osteotomies; however, an intracranial subdural hygroma has not yet been reported in oral and maxillofacial studies. We report a unique case of an intracranial subdural hygroma requiring neurosurgical intervention after Le Fort I advancement. PMID:25631863

  6. Gibbs free energies of formation of RuO 2, IrO 2, and OsO 2: A high-temperature electrochemical and calorimetric study

    NASA Astrophysics Data System (ADS)

    O'Neill, Hugh St. C.; Nell, Johan

    1997-12-01

    The Gibbs free energies of formation of RuO 2, OsO 2 and IrO 2 have been determined by measuring the chemical potentials of oxygen (μO 2) defined by the reactions M + O 2 = MO 2, where M = Ru, Os. or Ir, using an electrochemical method with calcia-stabilized zirconia (CSZ) solid electrolytes. Measurements were attempted in the temperature ranges from ˜870 K to 1620, 1270, and 1415 K for the Ru, Os, and Ir equilibria, respectively, but inspection of the results reveals that equilibrium could not be established below ˜930 K for all three reactions. For Ru + RuO 2, the highest temperature data (above 1520 K) may be systematically affected by the onset of significant electronic conduction in the CSZ electrolyte, while the attempted measurements of the Os + OsO 2 equilibrium above 1190 K are obscured by the disproportionation of OsO 2 to gaseous Os oxides. The high temperature heat capacities at constant pressure ( Cp) of RuO 2 and IrO 2 were determined from 370 to 1070 K by differential scanning calorimetry. These data were combined with heat content measurements and low-temperature heat capacities from the literature, and fitted to an extended Maier-Kelley equation. The calorimetric data for RuO 2 and IrO 2, together with assessed data for Ru, Os, and Ir metals and estimated data for OsO 2, were used in a third law analysis of the electrochemical measurements. The values of μO 2 of the three equilibria were smoothed and filtered by the third-law analysis to yield the following equations which can be extrapolated to lower and higher temperatures as indicated: μO 2 ( Ru + RuO 2) = -324563 + 344.151 T-22.1155 T ln T (700 ⩽ T ⩽ 1800) μO 2 ( Os + OsO 2) = -300399 + 307.639 T-17.4819 T ln T (700 ⩽ T ⩽ 1500) μO 2 ( Ir + IrO 2) = -256518 + 295.854 T-15.2368 T ln T (700 ⩽ T ⩽ 1500) where μO 2 is in J mol -1, T is in K, the reference pressure for O 2 is 1 bar (10 5 Pa), and estimated accuracies are approximately 200 to 400 J mol -1. For Ru + RuO 2, the drift

  7. The Use of Le by L1 Chinese Speakers and the Acquisition of Le by L2 Chinese Learners

    ERIC Educational Resources Information Center

    Bredeche, Chi Chen

    2011-01-01

    The perfective marker V-"le" is claimed to be one of the most problematic items in the acquisition of L2 Chinese, perhaps because no unified and comprehensive treatment of it exists in the literature. Although much has been written on this topic, the semantic and pragmatic functions of V-"le" have remained elusive. While linguists and grammarians…

  8. Energy levels, wavelengths, and radiative transition probabilities for the Na-like ions with 38 [le] Z [le] 45

    SciTech Connect

    Ying Zhang; Qiren Zhu; Shoufu Pan )

    1992-11-01

    The investigation by Z.-Q Zhang et al. (Acta Optica Sinica 11, 193, 1991) shows that it is possible to realize soft X-ray lasing in the water window 23.3-43.8 [Angstrom] with the Na-like recombination scheme, which requires a lower pumping power at a high-power laser facility than that with other schemes. The fine-structure levels with n [le] 15 and l [le] 6 in Na-like ions with 38 [le] Z [le] 45 and the probabilities for radiative transitions between these levels are calculated using the multiconfiguration Dirac-Fock approach. The calculations show that the wavelengths of the anticipated laser transitions 6 f-4d and 6g-4f in the Na-like ions with 38 [le] Z [le] 43 and 5f-4d and 5g-4f in the Na-like ions with 40 [le] Z [le] 45 lie in the region of the water window.

  9. Thermodynamic, structural, and dynamic properties of supercooled water confined in mesoporous MCM-41 studied with calorimetric, neutron diffraction, and neutron spin echo measurements

    NASA Astrophysics Data System (ADS)

    Yoshida, Koji; Yamaguchi, Toshio; Kittaka, Shigeharu; Bellissent-Funel, Marie-Claire; Fouquet, Peter

    2008-08-01

    Thermodynamic, structural, and dynamic properties of heavy water (D2O) confined in mesoporous silica glass MCM-41 C10, C12, and C14 were investigated by differential scanning calorimetry, neutron diffraction, and neutron spin echo (NSE) measurements, respectively. The DSC data showed that no crystallization of D2O confined in C10 occurs in a temperature range between 298 and 180 K, and that crystalline ice is formed at 204 and 221 K for C12 and C14, respectively. For C10, the neutron radial distribution functions of confined D2O suggested a structural change in the supercooled state between 223 and 173 K. For C10 sample, it has been found that the tetrahedral-like water structure is partially enhanced in the central part of pores at 173 K. For all the samples, the intermediate scattering functions from the NSE measurements are fitted by the Kohlrausch-Williams-Watts stretched exponential function which implies that confined supercooled D2O exhibits a wide distribution of relaxation times. For C10, C12, and C14 samples, between 298 and 240 K, the relaxation times of supercooled D2O follow remarkably well the Vogel-Fulcher-Tamman equation; for C10 sample, below 240 K, the relaxation times of nonfreezing D2O show an Arrhenius type behavior. From the present experimental results on calorimetric, structural, and dynamic properties, it has been concluded that supercooled D2O confined in MCM-41 C10 experiences a transition from high-density to low-density hydrogen-bonded structure at around 229 K.

  10. Interaction of cationic dodecyl-trimethyl-ammonium bromide with oxy-HbGp by isothermal titration and differential scanning calorimetric studies: Effect of proximity of isoelectric point.

    PubMed

    Alves, Fernanda Rosa; Carvalho, Francisco Adriano O; Carvalho, José Wilson P; Tabak, Marcel

    2016-04-01

    In this work, isothermal titration and differential scanning calorimetric methods, in combination with pyrene fluorescence emission and dynamic light scattering have been used to investigate the interaction of dodecyltrimethylammonium bromide (DTAB) with the giant extracellular Glossoscolex paulistus hemoglobin (HbGp) in the oxy-form, at pH values around the isoelectric point (pI ≈ 5.5). Our ITC results have shown that the interaction of DTAB with the hemoglobin is more intense at pH 7.0, with a smaller cac (critical aggregation concentration) value. The increase of protein concentration does not influence the cac value of the interaction, at both pH values. Therefore, the beginning of the DTAB-oxy-HbGp premicellar aggregates formation, in the cac region, is not affected by the increase of protein concentration. HSDSC studies show higher Tm values at pH 5.0, in the absence and presence of DTAB, when compared with pH 7.0. Furthermore, at pH 7.0, an aggregation process is observed with DTAB in the range from 0.75 to 1.5 mmol/L, noticed by the exothermic peak, and similar to that observed for pure oxy-HbGp, at pH 5.0, and in the presence of DTAB. DLS melting curves show a decrease on the hemoglobin thermal stability for the oxy-HbGp-DTAB mixtures and formation of larger aggregates, at pH 7.0. Our present data, together with previous results, support the observation that the protein structural changes, at pH 7.0, occur at smaller DTAB concentrations, as compared with pH 5.0, due to the acidic pI of protein that favors the oxy-HbGp-cationic surfactant interaction at neutral pH. PMID:26574155

  11. Calorimetric study of the effect of bent-shaped dopant molecules on the critical behavior at the nematic-smectic-Ad phase transition

    NASA Astrophysics Data System (ADS)

    Sasaki, Y.; Ema, K.; Le, K. V.; Takezoe, H.; Dhara, S.; Sadashiva, B. K.

    2011-06-01

    We report results of calorimetric studies for the binary mixture of rodlike host n-alkyloxy-cyanobiphenyl (nOCB, n=8,9) and bent-shaped guest 1,3-phenylene-bis[4-(3-methylbenzoyloxy)]-4'-n-dodecylbiphenyl-4'-carboxylate (BC12). The effect of bent-shaped dopant molecules on the critical behavior associated with the nematic-smectic-Ad phase transition has been studied in detail. The transition temperature for the nematic-smectic-Ad phase sharply decreases as the increase of the mole fraction of the dopant concentration (denoted X for the BC12/9OCB mixture and Y for the BC12/8OCB mixture). The dependence of the critical exponent α on X and Y is well explained in terms of the McMillan ratio. A nearly tricritical exponent has been obtained for the X=0.01 mixture. X=0.02-0.03 mixtures, pure 8OCB, and Y=0.01-0.03 mixtures exhibit nonuniversal behaviors with effective exponents lying between the 3D-XY and tricritical exponents. The heat capacity anomaly for Y=0.05 has been well described with the 3D-XY exponent. The critical amplitude ratio A-/A+ is close to 1 and insensitive to the dopant concentration. No Fisher renormalization of the critical exponent has been observed even for nearly tricritical compositions, which indicates the smallness of the concentration plays a decisive role rather than the steepness of the N-SmAd phase boundary.

  12. Calorimetric analysis of thermodynamic stability and aggregation for apo and holo amyotrophic lateral sclerosis-associated Gly-93 mutants of superoxide dismutase.

    PubMed

    Stathopulos, Peter B; Rumfeldt, Jessica A O; Karbassi, Farhad; Siddall, Clare A; Lepock, James R; Meiering, Elizabeth M

    2006-03-10

    Differential scanning calorimetry was used to measure changes in thermodynamic stability and aggregation for glycine 93 mutants of human copper, zinc-superoxide dismutase (SOD). Glycine 93 is a conserved residue at position i + 3 of a tight turn and has been found to be a mutational hot spot in familial amyotrophic lateral sclerosis (fALS). The fALS-associated mutations, G93A, G93S, G93R, G93D, and G93V, were made in a pseudo wild-type background containing no free cysteines, which prevented the formation of aberrant disulfide bonds upon thermal unfolding, and enabled quantitative thermodynamic analysis of the effects of the mutations. Thermal unfolding was highly reversible for all the SODs in both the fully metallated (holo) and metal-free (apo) forms. The data for all the holo-SODs and for the apo-pseudo-wild-type SOD were well fit by a 2-state unfolding model for native dimer (N2) to two unfolded monomers (2U), N2 <--> 2U. The holo- and apo-forms of the mutants are significantly destabilized (by 1.5-3.5 kcal mol(-1) monomer) relative to the corresponding forms of pseudo wild-type, with the relative stabilities being correlated with statistical preferences for amino acids in this structural context. Although van't Hoff (DeltaHvH) to calorimetric (DeltaHcal) enthalpy ratios are close to unity for all the holo-SODs and for apo-pseudo-wild-type, consistent with a 2-state transition, DeltaHvH is considerably larger than DeltaHcal for all the apo-mutants. This suggests that the mutations cause apo-SOD to have an increased propensity to misfold or aggregate, which may be linked to increased toxic mutant SOD aggregation in fALS. PMID:16407238

  13. Le contrôle des infections au cabinet du pédiatre

    PubMed Central

    2008-01-01

    RÉSUMÉ La transmission des infections au cabinet du pédiatre est de plus en plus préoccupante. Le présent document expose les voies de transmission des infections et les principes sous-jacents aux mesures actuelles pour contrôler les infections. Pour prévenir les infections, il faut bien concevoir le cabinet et adopter des politiques administratives et de triage convenables, de même que des pratiques de base pour les soins de tous les patients (p. ex., hygiène des mains, port de gants, de masques, de lunettes de protection et d’une blouse d’hôpital pour des interventions précises; nettoyage, désinfection et stérilisation convenables des surfaces et du matériel, y compris les jouets, et techniques d’asepsie en cas d’interventions effractives) et des précautions additionnelles en cas d’infections précises. Le personnel doit avoir reçu les vaccins pertinents, et les personnes infectées doivent respecter les politiques de restriction au travail.

  14. Les Hemorragies Gastroduodenales de Stress Chez le Brule Grave

    PubMed Central

    Siah, S.; Fouadi, F.E.; Ababou, K.; Nassim Sabah, T.; Ihrai, I.

    2008-01-01

    Summary Les Auteurs rapportent trois observations d'hémorragies gastroduodénales de stress chez le brûlé grave. Ils rappellent l'importance des mesures thérapeutiques qui doivent être prises chez le brûlé grave, comme le traitement du choc, du sepsis, des plaies et de la douleur, la nutrition entérale précoce et l'oxygénothérapie. Tout cela permet de réduire les facteurs de risque de survenue d'une hémorragie gastroduodénale de stress. PMID:21991137

  15. Automated Verification of Design Patterns with LePUS3

    NASA Technical Reports Server (NTRS)

    Nicholson, Jonathan; Gasparis, Epameinondas; Eden, Ammon H.; Kazman, Rick

    2009-01-01

    Specification and [visual] modelling languages are expected to combine strong abstraction mechanisms with rigour, scalability, and parsimony. LePUS3 is a visual, object-oriented design description language axiomatized in a decidable subset of the first-order predicate logic. We demonstrate how LePUS3 is used to formally specify a structural design pattern and prove ( verify ) whether any JavaTM 1.4 program satisfies that specification. We also show how LePUS3 specifications (charts) are composed and how they are verified fully automatically in the Two-Tier Programming Toolkit.

  16. Impact de la varicocèle sur le volume testiculaire et les paramètres spermatiques

    PubMed Central

    Benazzouz, Mohamed Hicham; Essatara, Younes; El Sayegh, Hachem; Iken, Ali; Benslimane, Lounis; Nouini, Yassine

    2014-01-01

    Introduction La varicocèle est une pathologie masculine fréquente dont l'incidence est encore plus importante dans dans la population des hommes infertiles. Si ses mécanismes sont à ce jour incomplètement expliqués il semble acquis que la varicocèle peut être associée a une dysfonction testiculaire avec diminution du volume testiculaire et de la concentration en spermatozoïde de l’éjaculat. Méthodes Dans un premier temps nous exposons les résultats d'une étude rétrospective sur 5 ans (de Mars 2009 à Mars 2014), réalisée au service d'urologie A de l'hôpital Ibn Sina de Rabat et ayant comme objectif d’évaluer l'impact de la varicocèle palpable sur le volume testiculaire et les paramètres spermatiques. Tous les patients inclus dans notre étude avaient une varicocèle palpable. Dans un deuxième temps, et à travers une revue de la littérature nous discutons l'impact du traitement de la varicocèle sur la fertilité. Résultats 39 patients ont été inclus dans notre étude. L’âge moyen était de 29,71 ans et la varicocèle siégeait dans 89,74% des cas du coté gauche. Une atrophie testiculaire homolatérale à la varicocèle était retrouvée dans 7% des cas alors que des anomalies du spermogramme se voyaient dans 69,23% des cas. Conclusion L'impact de la varicocèle sur l'altération des paramètres spermatiques a été clairement établi bien que sa physio pathogénie ne soit pas bien élucidée. Le traitement chirurgical de la varicocèle semble indiqué chez les hommes infertiles présentant une varicocèle clinique et une altération significative du sperme. PMID:25918574

  17. Non-exponential nature of calorimetric and other relaxations: Effects of 2 nm-size solutes, loss of translational diffusion, isomer specificity, and sample size

    NASA Astrophysics Data System (ADS)

    Johari, G. P.; Khouri, J.

    2013-03-01

    Certain distributions of relaxation times can be described in terms of a non-exponential response parameter, β, of value between 0 and 1. Both β and the relaxation time, τ0, of a material depend upon the probe used for studying its dynamics and the value of β is qualitatively related to the non-Arrhenius variation of viscosity and τ0. A solute adds to the diversity of an intermolecular environment and is therefore expected to reduce β, i.e., to increase the distribution and to change τ0. We argue that the calorimetric value βcal determined from the specific heat [Cp = T(dS/dT)p] data is a more appropriate measure of the distribution of relaxation times arising from configurational fluctuations than β determined from other properties, and report a study of βcal of two sets of binary mixtures, each containing a different molecule of ˜2 nm size. We find that βcal changes monotonically with the composition, i.e., solute molecules modify the nano-scale composition and may increase or decrease τ0, but do not always decrease βcal. (Plots of βcal against the composition do not show a minimum.) We also analyze the data from the literature, and find that (i) βcal of an orientationally disordered crystal is less than that of its liquid, (ii) βcal varies with the isomer's nature, and chiral centers in a molecule decrease βcal, and (iii) βcal decreases when a sample's thickness is decreased to the nm-scale. After examining the difference between βcal and β determined from other properties we discuss the consequences of our findings for theories of non-exponential response, and suggest that studies of βcal may be more revealing of structure-freezing than studies of the non-Arrhenius behavior. On the basis of previous reports that β → 1 for dielectric relaxation of liquids of centiPoise viscosity observed at GHz frequencies, we argue that its molecular mechanism is the same as that of the Johari-Goldstein (JG) relaxation. Its spectrum becomes broader on

  18. Complete thermodynamic characterization of the multiple protonation equilibria of the aminoglycoside antibiotic paromomycin: a calorimetric and natural abundance 15N NMR study.

    PubMed

    Barbieri, Christopher M; Pilch, Daniel S

    2006-02-15

    The binding of aminoglycoside antibiotics to a broad range of macromolecular targets is coupled to protonation of one or more of the amino groups that typify this class of drugs. Determining how and to what extent this linkage influences the energetics of the aminoglycoside-macromolecule binding reaction requires a detailed understanding of the thermodynamics associated with the protonation equilibria of the aminoglycoside amino groups. In recognition of this need, a calorimetric- and NMR-based approach for obtaining the requisite thermodynamic information is presented using paromomycin as the model aminoglycoside. Temperature- and pH-dependent 15N NMR studies provide pK(a) values for the five paromomycin amino groups, as well as the temperature dependence of these pK(a) values. These studies also indicate that the observed pK(a) values associated with the free base form of paromomycin are lower in magnitude than the corresponding values associated with the sulfate salt form of the drug. This difference in pK(a) is due to drug interactions with the sulfate counterions at the high drug concentrations (> or = 812 mM) used in the 15N NMR studies. Isothermal titration calorimetry studies conducted at drug concentrations < or = 45 microM reveal that the extent of paromomycin protonation linked to the binding of the drug to its pharmacologically relevant target, the 16 S rRNA A-site, is consistent with the pK(a) values of the free base and not the sulfate salt form of the drug. Temperature- and pH-dependent isothermal titration calorimetry studies yield exothermic enthalpy changes (deltaH) for protonation of the five paromomycin amino groups, as well as positive heat capacity changes (deltaC(p)) for three of the five amino groups. Regarded as a whole, the results presented here represent an important first step toward establishing a thermodynamic database that can be used to predict how aminoglycoside-macromolecule binding energetics will be influenced by conditions such

  19. Development status of LE-7 fuel turbopump

    NASA Astrophysics Data System (ADS)

    Nakano, T.; Nagao, R.; Ohta, T.; Warashina, S.; Watanabe, H.; Oguchi, H.

    The liquid hydrogen turbopump (LH2 T/P) for the LE-7 engine has been developed since 1984. The component PDR was held in June 1988 and the basic troubles occurred at the development test were solved. Next, the component CDR-1 was held in December 1989 in order to feed back the test results of prototype LH2 T/P model to the design of qualification phase T/P. So, the production of these turbopumps was admitted. Recently, the component CDR-2 was held in February 1992 to reflect the counterparts adopted for some troubles (impeller and turbine blade cracks and so on) in long-time engine tests to the design of qualification phase T/P. In the qualification phase, the hydraulic characteristics and strength in the engine operating range were examined at the LH2 T/P component test, and its endurance confirmed at the engine tests. The LH2 turbopump component test was held at NASDA Kakuda and the engine test at Tashiro and Tanegashima. This paper describes the development status of LH2 T/P, containing the design description and the content of some troubles and its counterplans.

  20. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2007-09-01

    Anions interstellaires; S Orionis; Altaîr; Courants stellaires; Etoiles jeunes; 2MASSW J1207334-393254; Alpha Andromède; Etoiles à neutrons (1); LH54-425; AGNs invisibles; Deux supernovae; Les GRBs seon Swift; Peser les trous noirs; Formation de trous noirs; Trou noir; ondes gravitationnelles : Virgo entre dans sa phase d'exploitation scientifique; Amas de galaxies actifs; Amas de galaxies; Galaxies actives d'amas; L'univers statique: le retour; Macho; Exoplanètes; Exoplanètes habitables?; Exoplanètes habitables? (suite); Une année d'un an; Une année de 31 heures; Valse des Jupiters; Disque de HD 15115; Impact majeur; Planètes isolées; Super-Jupiter; Impact et mini-extinction; L'effet Pioneer; Toungouska; Spéléo martienne; Autres lunes dactives; Encelade; Hypérion; Pluton dépassé; Satellites d'Uranus; Titan

  1. Transmaxillary Sinus Approach for Le Fort II Osteotomy

    PubMed Central

    Fukawa, Toshihiko; Hirakawa, Takashi; Satake, Toshihiko; Maegawa, Jiro

    2016-01-01

    Summary: The Le Fort II osteotomy is a relatively rare operation. The posterior wall osteotomy of the maxillary sinus (MS) is often difficult for Le Fort III. We developed the transmaxillary sinus approach (TSA) for the Le Fort II osteotomy that cuts the posterior wall of the MS directly. This report illustrates this easy-to-use procedure for the Le Fort II osteotomy in syndromic craniosynostosis. This procedure was performed in an 18-year-old patient with Apert syndrome and a 15-year-old patient with Pfeiffer syndrome. The thin anterior walls of the MS were removed through an intraoral approach to look inside the MS. Then, the posterior walls were cut by chisel under direct vision using light. The other osteotomy was performed as usual. Distraction osteogenesis with internal and external devices was used in combination. The advantages of TSA are the direct posterior wall osteotomy of the MS with no down fracture and minimal invasiveness to the mucosa of the MS under direct vision. However, the disadvantage is that TSA becomes a blind procedure in a case with no MS or hypoplasia. We developed the TSA for the Le Fort II osteotomy, which could provide direct observation and perform the posterior wall osteotomy of the MS without down fracture. We believe that TSA is an effective surgical procedure for the Le Fort II osteotomy. PMID:27014548

  2. Transmaxillary Sinus Approach for Le Fort II Osteotomy.

    PubMed

    Kobayashi, Shinji; Fukawa, Toshihiko; Hirakawa, Takashi; Satake, Toshihiko; Maegawa, Jiro

    2016-02-01

    The Le Fort II osteotomy is a relatively rare operation. The posterior wall osteotomy of the maxillary sinus (MS) is often difficult for Le Fort III. We developed the transmaxillary sinus approach (TSA) for the Le Fort II osteotomy that cuts the posterior wall of the MS directly. This report illustrates this easy-to-use procedure for the Le Fort II osteotomy in syndromic craniosynostosis. This procedure was performed in an 18-year-old patient with Apert syndrome and a 15-year-old patient with Pfeiffer syndrome. The thin anterior walls of the MS were removed through an intraoral approach to look inside the MS. Then, the posterior walls were cut by chisel under direct vision using light. The other osteotomy was performed as usual. Distraction osteogenesis with internal and external devices was used in combination. The advantages of TSA are the direct posterior wall osteotomy of the MS with no down fracture and minimal invasiveness to the mucosa of the MS under direct vision. However, the disadvantage is that TSA becomes a blind procedure in a case with no MS or hypoplasia. We developed the TSA for the Le Fort II osteotomy, which could provide direct observation and perform the posterior wall osteotomy of the MS without down fracture. We believe that TSA is an effective surgical procedure for the Le Fort II osteotomy. PMID:27014548

  3. Three-dimensional Nasolabial Morphologic Alterations Following Le Fort I

    PubMed Central

    DeSesa, Christopher R.; Metzler, Philip; Sawh-Martinez, Rajendra

    2016-01-01

    Background: Le Fort I osteotomy imparts significant changes to the nasolabial region. Past studies have relied on 2-dimensional data and have not delineated differences among various Le Fort I subtypes. The purpose of this study is to 3-dimensionally analyze Le Fort I–induced nasal and lip changes comparing advancement alone versus widening alone [surgically assisted maxillary expansion (SAME)] versus advancement and widening. We hypothesize that the combination of maxillary advancement with widening will result in the most profound changes. Methods: A retrospective cohort study was performed. Included Le Fort I patients were grouped as: (1) nonsegmental straight advancement, (2) widening without advancement, and (3) segmental advancement and widening. Pre- and postoperative 3-dimensional photogrammetry (Canfield) were analyzed. Anthropometric landmarks were placed and measured by 2 independent observers. Statistics involved both paired and unpaired t tests (significance = P < 0.05). Results: One hundred eight photogrammetric data sets were analyzed, including 46 single-piece, 26 SAME, and 36 segmental. Significant postoperative nasal changes were observed within each intragroup analysis. The most dramatic changes were seen after segmental Le Fort I with advancement and widening, which included alar base width, alar width, nostril width, and soft triangle angle, all P < 0.05. Conclusions: Le Fort I osteotomy results in significant alteration of the nasolabial morphology. This is the first study to 3-dimensionally analyze nasal changes that occur comparing maxillary advancement alone versus widening alone (SAME) versus advancement with widening. These objective data permit improved patient counseling and surgical planning. PMID:27622116

  4. Lactobacillus equigenerosi Strain Le1 Invades Equine Epithelial Cells

    PubMed Central

    Botha, Marlie; Botes, Marelize; Loos, Ben; Smith, Carine

    2012-01-01

    Lactobacillus equigenerosi strain Le1, a natural inhabitant of the equine gastrointestinal tract, survived pH 3.0 and incubation in the presence of 1.5% (wt/vol) bile salts for at least 2 h. Strain Le1 showed 8% cell surface hydrophobicity, 60% auto-aggregation, and 47% coaggregation with Clostridium difficile C6. Only 1% of the cells adhered to viable buccal epithelial cells and invaded the cells within 20 min after contact. Preincubation of strain Le1 in a buffer containing pronase prevented adhesion to viable epithelial cells. Preincubation in a pepsin buffer delayed invasion from 20 min to 1 h. Strain Le1 did not adhere to nonviable epithelial cells. Administration of L. equigenerosi Le1 (1 × 109 CFU per 50 kg body weight) to healthy horses did not increase white blood cell numbers. Differential white blood cell counts and aspartate aminotransferase levels remained constant. Glucose, lactate, cholesterol, and urea levels remained constant during administration with L. equigenerosi Le1 but decreased during the week after administration. PMID:22504808

  5. Searching the animal psyche with Charles Le Brun.

    PubMed

    Cohen, Sarah R

    2010-07-01

    Around 1670 the French court painter and Academician Charles Le Brun produced a series of drawings featuring naturalistic animal heads, as well as imaginary heads in which he refashioned various nonhuman animal species to make humanoid physiognomies. What were the purpose and significance of these unusual works? I argue that they show Le Brun's interest in what we today would call animal psychology: focusing upon the sensory organs and their connections with the animal's brain, Le Brun studied his animals as conscious protagonists of the natural realm. One source that may have served him in this project was Marin Cureau de La Chambre's De la Connoissance des bestes of 1645, in which the physician argued that animals possess a conscious soul grounded in the senses. However, Le Brun's animal-humans have no clear place in the artist's taxonomy--nor, indeed, in any seventeenth-century understandings of species. It is rather John Locke, at his most skeptical, who offers the best parallel in the realm of natural philosophy to Le Brun's unsettling animal-humans. Probably without meaning to, Le Brun demonstrated through his eerie, boundary-crossing creatures the limits of visual classification. PMID:20853815

  6. Micro-machined calorimetric biosensors

    DOEpatents

    Doktycz, Mitchel J.; Britton, Jr., Charles L.; Smith, Stephen F.; Oden, Patrick I.; Bryan, William L.; Moore, James A.; Thundat, Thomas G.; Warmack, Robert J.

    2002-01-01

    A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of a substance.

  7. Le Point sur la Pharmacologie des Agents Anesthesiques Chez le Brule Grave

    PubMed Central

    Siah, S.; Ababou, K.; Benziane, H.; El Jaoudi; Bensghir, M.; Bakali, H.; El Wali, A.; Ihrai, I.; Drissi, N.K.

    2008-01-01

    Summary La pharmacologie des agents anesthésiques chez le brûlé est variable et imprévisible. Dans les premières 48 h, il y a une hypovolémie avec chute du débit cardiaque et des fuites plasmatiques. Après 48 h, il y a une hypervolémie avec augmentation du débit cardiaque, hypermétabolisme et la clearance des médicaments est augmentée. Parmi les facteurs de déséquilibre, on retrouve les variations des protéines plasmatiques. Deux protéines sont importantes chez le brûlé grave : l'albumine et l'alpha 1- glycoprotéine. Leur taux varie beaucoup au cours de l'évolution de la brûlure. Les agents anesthésiques dont la liaison avec ces deux protéines est prédominante verront leur pharmacocinétique modifiée. L'anesthésiste-réanimateur du service des brûlés va maîtriser ces notions pharmacologiques pour utiliser à bon escient les agents anesthésiques. PMID:21991108

  8. Synthesis of a BSA-Le(x) glycoconjugate and recognition of Le(x) analogues by the anti-Le(x) monoclonal antibody SH1: the identification of a non-cross reactive analogue.

    PubMed

    Wang, Jo-Wen; Asnani, Ari; Auzanneau, France-Isabelle

    2010-10-15

    A Le(x) trisaccharide functionalized with a cysteamine arm was prepared and this synthesis provided additional information on the reactivity of N-acetylglucosamine O-4 acceptors when they are glycosylated with trichloroacetimidate donors activated with excess BF(3)·OEt(2). In turn, this trisaccharide was conjugated to BSA lysine side chains through a squarate-mediated coupling. This BSA-Le(x) glycoconjugate displayed 35 Le(x) haptens per BSA molecule. The relative affinity of the anti-Le(x) monoclonal antibody SH1 for the Le(x) antigen and analogues of Le(x) in which the D-glucosamine, L-fucose or D-galactose residues were replaced with D-glucose, L-rhamnose and D-glucose, respectively, was measured by competitive ELISA experiments. While all analogues were weaker inhibitors than the Le(x) antigen, only the analogue of Le(x) in which the galactose residue was replaced by a glucose unit showed no binding to the SH1 mAb. To confirm that the reduced or loss of recognition of the Le(x) analogues by the anti-Le(x) mAb SH1 did not result from different conformations adopted by the analogues when compared to the native Le(x) antigen, we assessed the conformational behavior of all trisaccharides by a combination of stochastic searches and NMR experiments. Our results showed that, indeed, the analogues adopted the same stacked conformation as that identified for the Le(x) antigen. The identification of a trisaccharide analogue that does not cross-react with Le(x) but still retains the same conformation as Le(x) constitutes the first step to the design of a safe anti-cancer vaccine based on the dimeric Le(x) tumor associated carbohydrate antigen. PMID:20843695

  9. Un exemple de transfert de technologie dans le domaine des polymères conducteurs : le projet ``HYRA"

    NASA Astrophysics Data System (ADS)

    Parneix, J. P.; Miane, J. L.; Colin, T.; Ruffie, G.; Mege, J.

    1998-06-01

    The HYRA project is a response to the restructuration of local companies : these are purveyors of high technology military and spatial especially in the radars business. Furthermore, the development of mobile communications needs devices and materials in the millimeter range (from 20 to 100Ghz). The aim of the HYRA project is the development of materials with specific properties - particularly conducting materials - in the millimeter wave range. The results obtained on thermoplastic/conducting polymer composites are presented. Le projet HYRA répond à des préoccupations régionales liées à des restructurations industrielles : les industries régionales fournissant les marchés militaires et spatiaux disposent de techniques très performantes mais coûteuses, en particulier dans le domaine des radars. Par ailleurs le développement des communications mobiles a besoin de dispositifs et de matériaux dans tout le domaine millimétrique (de 20 à 100 Ghz). Le projet HYRA a pour but le développement de matériaux à propriétés spécifiques - en particulier conducteurs - dans ce domaine de fréquence. Les résultats obtenus sur des composites thermoplastiques/polymères conducteurs sont présentés.

  10. Transitions de phase dans le oxyde de yttrium vanadium

    NASA Astrophysics Data System (ADS)

    Roberge, Benoit

    Dans le mémoire qui suit, les ordres structural, magnétiques et orbital dans le YVO3 sont étudiés avec l'aide de la diffraction des rayons X,de la spectroscopie Raman et de la technique de la cavité résonnante hyperfréquence. L'objectif premier consiste à observer l'évolution de ces ordres en fonction de la température. Le mémoire met ensuite en évidence le couplage entre les différents ordres cohabitants dans le YVO3 . Les mesures effectuées par la diffraction des rayons X permettent de mesurer le caractère polycrystallin des échantillons du YVO 3. Une comparaison de nos mesures avec des mesures de diffraction des rayons X faites sur la poudre de YVO3 indique la faible présence de maclage. Les mesures effectuées avec la technique de résonnance hyperfréquence permettent de suivre l'évolution de la constante diélectrique en fonction de la température. Les changements impliquant l'ordre orbital se manifestent de manière évidente dans la constante diélectrique à 200 K et à 77 K. La transition diélectrique détectée à 77 K est une transition de premier ordre. Un couplage entre les propriétés diélectriques et magnétiques est observable à la température de Néel à 114 K. L'effet d'un champ magnétique fixe sur la température de transition de l'ordre orbital survenant à 77 K est également remarquable. Cela indique un couplage magnétodiélectrique démontrant ainsi le caractère multiferroïque du YVO 3. Finalement, l'observation d'un mécanisme de relaxation pouvant être modélisé par le modèle d'Havriliak-Negami est observé en dessous de 77 K. En utilisant le modèle d'Arrhénius et le modèle d'Havriliak-Negami, on peut caractériser le mécanisme avec son énergie d'activation et son temps de relaxation. Les mesures effectuées en spectroscopie Raman permettent de suivre l'évolution de la structure du YVO3 en fonction de la température. Les deux changements structuraux survenant à 200 K et 77 K sont observés. Le

  11. Lele de métrologie de SOLEIL

    NASA Astrophysics Data System (ADS)

    Idir, M.; Brochet, S.; Delmotte, A.; Lagarde, B.; Mercere, P.; Moreno, T.; Polack, F.; Thomasset, M.

    2006-12-01

    Lele de METROLOGIE de SOLEIL a pour objet de créer sur le synchrotron SOLEIL, une plateforme constituée : - une ligne de lumière utilisant le rayonnement synchrotron (métrologie dite à la longueur d'onde) - d'un laboratoire de métrologie associé (métrologie dite ll classique gg ) Ces deux types de Métrologie sont l'une et l'autre indispensables pour soutenir l'activité de recherche instrumentale en optique X et X-UV. Ce projet de pôle de METROLOGIE ne répondra pas seulement aux besoins des groupes chargés de l'équipement du synchrotron SOLEIL en optiques et détecteurs mais aussi pour préparer, tester et mettre au point les postes expérimentaux, ce qui concerne déjà une large communauté d'utilisateurs. Il sera aussi largement ouvert, dès sa mise en service, à l'ensemble de la communauté scientifique concernée par l'instrumentation X et XUV en Ile de France, en France, voire même en Europe si la demande continue de croître plus vite que l'offre dans ce domaine. Ligne de lumière Métrologie à la longueur d'onde La ligne de lumière sera équipée de plusieurs stations permettant de mesurer, dans la plus grande partie du spectre couvert par le synchrotron, les paramètres photométriques qui caractérisent les éléments optiques, tels que : la réflectivité de surfaces, l'efficacité de diffraction des réseaux, la diffusion des surfaces ou l'efficacité des détecteurs X et X-UV et la calibration absolue. Cette installation pourra servir également à développer des instruments et des diagnostics nécessaires à la caractérisation des faisceaux de rayons X (intensité, taille, degré de cohérence, polarisation etc.) Métrologie Classique La métrologie des surfaces optiques est devenue une nécessité critique pour les laboratoires et les industries qui utilisent les photons X et X-UV (synchrotrons, centres laser, etc. .). En effet, les progrès de calcul et de conception des systèmes optiques pour ces longueurs d'onde (optiques

  12. Expression of blood group antigens H-2, Le(y), and sialylated-Le(a) in human colorectal carcinoma. An immunohistochemical study using double-labeling techniques.

    PubMed Central

    Cooper, H. S.; Malecha, M. J.; Bass, C.; Fagel, P. L.; Steplewski, Z.

    1991-01-01

    In this study, double-labeling immunohistochemistry was used to gain insight into the coexpression or interrelationship between blood group antigens (BGA) that are differentiation antigens in the normal colon, and BGA that are sequential moieties in the same synthetic pathway. Paired-wise Sialylated-Le(a)/Le(y) and H-2/Le(y) was studied. The Sialylated-Le(a) and Le(y) are synthesized from type 1 and type 2 backbones, respectively. In the normal colon, the Le(y) and Sialylated-Le(a) are expressed by cells at the base and surface of the crypt, respectively, representing undifferentiated and differentiated enterocytes. The H-2 is considered oncofetal in nature, and is considered to be the immediate precursor in the synthesis of Le(y). In individual cancers. Sialylated-Lea and Le(y) were detected in different cancer cells within the same malignant glands, separately in different glands, and in different subcellular compartments of the same cell. Both H-2 and Le(y) were coexpressed in the same individual cells in 92% of cancers expressing both these BGA. In 50% of the cancers, the H-2 and Le(y) also were expressed separately in different malignant glands within individual tumors. These findings indicate that, in colorectal cancers, differentiation antigens (Sialylated Le(a) and Le(y)) are expressed by different individual cells within the same malignant gland somewhat, recapitulating the normal colon crypt. Antigens of different backbones occasionally may be expressed in the same cells but within different subcellular compartments. Precursor accumulation is common in cancers, and antigens in the same synthetic pathway are coexpressed in the same cell. The expression of H-2 and Le(y) in different glands (lack of coexpression) may be explained possibly by aberrant synthesis of Le(y) by an alternate pathway. Images Figure 1 PMID:1987759

  13. Trigeminocardiac reflex and haemodynamic changes during Le Fort I osteotomy.

    PubMed

    Kiani, M T; Tajik, G; Ajami, M; Fazli, H; Kharazifard, M J; Mesgarzadeh, A

    2016-05-01

    The Le Fort I osteotomy is performed under general anaesthesia and specific haemodynamic conditions, i.e. hypotensive general anaesthesia. This study assessed the incidence of the trigeminocardiac reflex (TCR) during the different stages of the Le Fort I osteotomy. Forty-seven patients requiring a Le Fort I osteotomy were included. General anaesthesia was induced. In terms of haemodynamic changes, each patient's oxygen saturation (SpO2), mean arterial pressure (MAP), heart rate (HR), and electrocardiogram (ECG) were monitored by SADAAT Monitoring System and recorded during the different stages of osteotomy: before the induction of anaesthesia, before osteotomy cuts, after finishing the right pterygoid plate osteotomy, after finishing the left pterygoid plate osteotomy, and after performing down-fracture of the maxilla. No significant alteration in haemodynamic values was seen at the different stages of Le Fort I osteotomy. One patient showed arrhythmia with non-sinus junction rhythm after sinus bradycardia and two premature atrial contractions in the down-fracture stage, which led to the abrupt cessation of the procedure by the surgeon. This study showed no significant alterations in haemodynamic values during the different stages of Le Fort I osteotomy. Halting the procedure momentarily was sufficient to allow spontaneous normalization of the HR, blood pressure, and dysrhythmia. PMID:26794400

  14. Le lipome para testiculaire: à propos d'un cas rare

    PubMed Central

    Lasri, Abdelouahed; Lamchahab, Hamza; Lahyani, Mounir; Karmouni, Tarik; Elkhader, Khalid; Koutani, Abdellatif; Andaloussi, Ahmed Ibn Attya

    2015-01-01

    Les tumeurs para testiculaires sont des tumeurs rares et complexes qui ont une symptomatologie insidieuse et pauvre. Les formes bénignes représentent 70%. Le lipome para testiculaire étant le type le plus fréquent. L'examen clinique est peu spécifique. L'examen échographique est la pierre angulaire pour assoir le diagnostic. Le traitement chirurgical s'impose en cas de tumeur symptomatique, l'histologie étant habituellement typique permet la confirmation diagnostique. Le pronostic est bon malgré d’éventuelles récidives. PMID:26175802

  15. Pterygoid Plate Fractures: Not Limited to Le Fort Fractures.

    PubMed

    Garg, Ravi K; Alsheik, Nila H; Afifi, Ahmed M; Gentry, Lindell R

    2015-09-01

    Pterygoid plate fractures are often described in the setting of Le Fort fractures. The goal of this study was to define other craniofacial fracture patterns causing injury to the pterygoid plates. A retrospective review of computed tomography (CT) scans obtained on craniofacial trauma patients over a 5-year period revealed 209 patients with pterygoid plate fractures. Pterygoid plate fractures in 78 patients (37.3%) were unrelated to Le Fort fractures. Common causes included sphenotemporal buttress fractures in 26 patients (33.3%), temporal bone fractures in 18 patients (23.1%), zygomaticomaxillary complex fractures in 17 patients (21.8%), and displaced mandible fractures in 14 patients (17.9%). These findings indicate that approximately one third of pterygoid plate fractures do not result from Le Fort pattern injuries and that the craniofacial surgeon should have a broad differential for causes of pterygoid plate fractures when reviewing trauma imaging. PMID:26147022

  16. Le zona ophtalmique: une dermatose rare chez l'enfant

    PubMed Central

    Zakia, Douhi; Meziane, Marieme; Salim, Gallouj; Zahra, Mernissi Fatima

    2015-01-01

    Le zona est dû a une réactivation du virus varicelle-zona (VZV) qui reste quiescent dans les ganglions sensitifs dorsaux après la varicelle. Le zona de l'enfant est rare et particulièrement la forme ophtalmique, qui peut être responsable de complications oculaires graves nécessitant une prise en charge adéquate et précoce. Il est parfois associé à des douleurs post-zostériennes dont le traitement est difficile. L'aciclovir per os administré dans les 72 heures après l’éruption a prouvé son efficacité dans la prévention des complications oculaires. Nous en rapportant un nouveaux cas chez un garçon immunocompétent de 9 ans, sans notion de varicelle antérieure. PMID:26955408

  17. Low-temperature heat capacity of diopside glass (CaMgSi2O6): A calorimetric test of the configurational-entropy theory applied to the viscosity of liquid silicates

    USGS Publications Warehouse

    Richet, P.; Robie, R.A.; Hemingway, B.S.

    1986-01-01

    Heat-capacity measurements have been made between 8 and 370 K on an annealed and a rapidly quenched diopside glass. Between 15 and 200 K, Cp does not depend significantly on the thermal history of the glass. Below 15 K Cp is larger for the quenched than for the annealed specimen. The opposite is true above 200 K as a result of what is interpreted as a secondary relaxation around room temperature. The magnitude of these effects, however, is small enough that the relative entropies S(298)-S(0) of the glasses differ by only 0.5 J/mol K, i.e., a figure within the combined experimental uncertainties. The insensitivity of relative entropies to thermal history supports the assumption that the configurational heat capacity of the liquid may be taken as the heat capacity difference between the liquid and the glass (??Cp). Furthermore, this insensitivity allows calculation of the residual entropies at 0 K of diopside glasses as a function of the fictive temperature from the entropy of fusion of diopside and the heat capacities of the crystalline, glassy and liquid phases. For a glass with a fictive temperature of 1005 K, for example, this calorimetric residual entropy is 24.3 ?? 3 J/mol K, in agreement with the prediction made by RICHET (1984) from an analysis of the viscosity data with the configurational-entropy theory of relaxation processes of Adam and Gibbs (1965). In turn, all the viscosity measurements for liquid diopside, which span the range 0.5-4?? 1013 poise, can be quantitatively reproduced through this theory with the calorimetrically determined entropies and ??Cp data. Finally, the unclear significance of "activation energies" for structural interpretations of viscosity data is emphasized, and the importance of ??Cp and glass-transition temperature systematics for determining the composition and temperature dependences of the viscosity is pointed out. ?? 1986.

  18. Restorative Justice Scripts in Ursula K. Le Guin's "Voices"

    ERIC Educational Resources Information Center

    Oziewicz, Marek C.

    2011-01-01

    This essay examines restorative justice scripting in "Voices", the second volume of Ursula K. Le Guin's "Annals of the Western Shore." Narrated by a rape-child, "Voices" is the story of an occupied city-state and of how the conquered and the conquerors negotiate a formula for peaceful coexistence. They are able to do so by enacting a restorative…

  19. Decolonizing the Choctaws: Teaching LeAnne Howe's "Shell Shaker"

    ERIC Educational Resources Information Center

    Hollrah, Patrice

    2004-01-01

    "Shell Shaker" (2001) by LeAnne Howe (Choctaw) is a novel that gives students an opportunity to learn that the history and culture of the Choctaw Nation of Oklahoma are alive today. Winner of the Before Columbus Foundation American Book Award in 2002, the novel deals with two parallel stories that converge in the present, one about the eighteenth…

  20. Le Dernier Cartoucherie: Refuge and the Performance of Care

    ERIC Educational Resources Information Center

    Fisek, Emine

    2008-01-01

    In 2003, the Paris-based theatre company Theatre du Soleil launched "Le Dernier Caravanserail: Odyssees", a collaborative creation based on stories that company members had collected from refugees at the Sangatte refugee camp outside Calais, among other locations. Scenes of moral reasoning dotted the six-hour spectacle, calling to mind the…

  1. LeRC in-house experimental research

    NASA Technical Reports Server (NTRS)

    Lyons, Valerie J.

    1992-01-01

    The topics covered include the following: LeRC in-house experimental research; combustion concepts; schedule for in-house experiments; lean premixed prevaporized combustion; comparisons of low NO(x) lean premixed/prevaporized data; rich burn/quick quench/lean burn (RQL); RQL combustion; fuel rich catalytic combustion; advanced diagnostics; and ceramic matrix liner test rig.

  2. Ursula LeGuin's Magical World of Earthsea.

    ERIC Educational Resources Information Center

    Griffin, Jan M.

    1996-01-01

    Discusses how Ursula LeGuin's Earthsea Trilogy reflects her belief in Taoist philosophy as well as her skill in telling stories of magic and adventure. Notes that the three books can be described as coming-of-age novels in which three separate individuals struggle to become mature, responsible, whole adults. (RS)

  3. MoLeNET Mobile Learning Conference 2009: Research Papers

    ERIC Educational Resources Information Center

    Guy Parker, Ed.

    2010-01-01

    The Mobile Learning Network (MoLeNET) is a unique collaborative approach to encouraging, supporting, expanding and promoting mobile learning, primarily in English post-14 education and training, via supported shared cost mobile learning projects. Collaboration at national level involves participating institutions and the Learning and Skills…

  4. LHC, le Big Bang en éprouvette

    ScienceCinema

    None

    2011-10-06

    Notre compréhension de l?Univers est en train de changer? Bar des Sciences - Tout public Débat modéré par Marie-Odile Montchicourt, journaliste de France Info. Evenement en vidéoconférence entre le Globe de la science et de l?innovation, le bar le Baloard de Montpellier et la Maison des Métallos à Paris. Intervenants au CERN : Philippe Charpentier et Daniel Froideveaux, physiciens au CERN. Intervenants à Paris : Vincent Bontemps, philosophe et chercheur au CEA ; Jacques Arnould, philosophe, historien des sciences et théologien, Jean-Jacques Beineix, réalisateur, producteur, scénariste de cinéma. Intervenants à Montpellier (LPTA) : André Neveu, physicien théoricien et directeur de recherche au CNRS ; Gilbert Moultaka, physicien théoricien et chargé de recherche au CNRS. Partenariat : CERN, CEA, IN2P3, Université MPL2 (LPTA) Dans le cadre de la Fête de la science 2008

  5. Le syndrome d'embolie graisseuse post traumatique

    PubMed Central

    Berdai, Adnane Mohamed; Shimi, Abdelkarim; Khatouf, Mohammed

    2014-01-01

    Le syndrome d'embolie graisseuse est une complication grave des fractures des os longs, il est la conséquence de la dissémination des particules graisseuses dans la microcirculation. L'objectif de ce travail est de déterminer le profil épidémiologique, la présentation clinique et paraclinique de ce syndrome et sa prise en charge thérapeutique. Notre étude porte sur 11 cas de syndrome d'embolie graisseuse colligés au service de réanimation A1 au centre hospitalier universitaire Hassan II de Fès, de Janvier 2009 à Juin 2012. Le diagnostic positif est basé sur les critères de Gurd. Les cas collectés se caractérisent par la prédominance du sexe masculin, d'un âge inférieur à 40 ans, présentant une fracture fémorale. Ce syndrome survient souvent dans les 72 heures après le traumatisme. La présentation clinique est dominée par l'hypoxémie et les troubles de conscience. Sur le plan biologique: l'anémie et la thrombopénie sont les manifestations les plus fréquentes. La prise en charge est symptomatique, 63% des patients ont nécessité l'intubation et la ventilation. L’évolution n'est pas toujours bénigne. Nos résultats confirme le polymorphisme de la présentation clinique et paraclinique du syndrome d'embolie graisseuse. Le diagnostic de ce syndrome se base sur des critères cliniques, mais reste essentiellement un diagnostic d’élimination. La prise en charge est symptomatique. La prévention de ce syndrome est essentielle et se base sur une fixation précoce des fractures des os longs. PMID:25452829

  6. Connecting Instructional and Cognitive Aspects of an LE: A Study of the Global Seminar Project

    ERIC Educational Resources Information Center

    Savelyeva, Tamara

    2012-01-01

    My research problem is based on the lack of unifying conceptual cohesion between the discourses concerning cognitive and instructional aspects of learning environments (LE). I contrast that lack with practical developments of LE studies connected at the level of practical implementation and evaluation. Next, I briefly review the LE boundaries,…

  7. Le traitement familial des enfants et des adolescents anorexiques : Des lignes directrices pour le médecin communautaire

    PubMed Central

    Findlay, S; Pinzon, J; Taddeo, D; Katzman, DK

    2010-01-01

    L’anorexie mentale (AM) est une maladie grave qui met la vie en danger et qui fait généralement son apparition pendant l’adolescence. Les données probantes au sujet du traitement optimal de l’AM chez les enfants et les adolescents sont en croissance, mais il reste beaucoup à apprendre. Même si les démarches thérapeutiques actuelles varient au Canada et ailleurs, les données jusqu’à présent indiquent que le traitement familial (TF) est le plus efficace pour les enfants et les adolescents anorexiques. Un élément essentiel du modèle de TF, c’est que les parents sont investis de la responsabilité de rétablir la santé physique de leur enfant et de s’assurer de la reprise complète de son poids. Le médecin qui comprend les principes fondamentaux et la philosophie du TF peut mettre en place les éléments de cette intervention fondée sur des faits probants auprès des jeunes patients anorexiques et de leur famille.

  8. The scope of the LeChatelier Principle

    NASA Astrophysics Data System (ADS)

    George M., Lady; Quirk, James P.

    2007-07-01

    LeChatelier [Comptes Rendus 99 (1884) 786; Ann. Mines 13 (2) (1888) 157] showed that a physical system's “adjustment” to a disturbance to its equilibrium tended to be smaller as constraints were added to the adjustment process. Samuelson [Foundations of Economic Analysis, Harvard University Press, Cambridge, 1947] applied this result to economics in the context of the comparative statics of the actions of individual agents characterized as the solutions to optimization problems; and later (1960), extended the application of the Principle to a stable, multi-market equilibrium and the case of all commodities gross substitutes [e.g., L. Metzler, Stability of multiple markets: the hicks conditions. Econometrica 13 (1945) 277-292]. Refinements and alternative routes of derivation have appeared in the literature since then, e.g., Silberberg [The LeChatelier Principle as a corollary to a generalized envelope theorem, J. Econ. Theory 3 (1971) 146-155; A revision of comparative statics methodology in economics, or, how to do comparative statics on the back of an envelope, J. Econ. Theory 7 (1974) 159-172], Milgrom and Roberts [The LeChatelier Principle, Am. Econ. Rev. 86 (1996) 173-179], W. Suen, E. Silberberg, P. Tseng [The LeChatelier Principle: the long and the short of it, Econ. Theory 16 (2000) 471-476], and Chavas [A global analysis of constrained behavior: the LeChatelier Principle ‘in the large’, South. Econ. J. 72 (3) (2006) 627-644]. In this paper, we expand the scope of the Principle in various ways keyed to Samuelson's proposed means of testing comparative statics results (optimization, stability, and qualitative analysis). In the optimization framework, we show that the converse LeChatelier Principle also can be found in constrained optimization problems and for not initially “conjugate” sensitivities. We then show how the Principle and its converse can be found through the qualitative analysis of any linear system. In these terms, the Principle and

  9. Ultrafast intramolecular charge transfer with N-(4-cyanophenyl)carbazole. Evidence for a LE precursor and dual LE + ICT fluorescence.

    PubMed

    Galievsky, Victor A; Druzhinin, Sergey I; Demeter, Attila; Mayer, Peter; Kovalenko, Sergey A; Senyushkina, Tamara A; Zachariasse, Klaas A

    2010-12-01

    The photophysics of N-(4-cyanophenyl)carbazole (NP4CN) was investigated by using absorption and fluorescence spectra, picosecond fluorescence decays, and femtosecond transient absorption. In the nonpolar n-hexane as well as in the polar solvent acetonitrile (MeCN), a locally excited (LE) state is detected, as a precursor for the intramolecular charge transfer (ICT) state. A LE → ICT reaction time τ(2) at 22 °C of 0.95 ps in ethyl cyanide (EtCN) and 0.32 ps in MeCN is determined from the decay of the LE excited state absorption (ESA) maximum around 620 nm. In the ESA spectrum of NP4CN in n-hexane at a pump-probe delay time of 100 ps, an important contribution of the LE band remains alongside the ICT band, in contrast to what is observed in EtCN and MeCN. This shows that a LE ⇄ ICT equilibrium is established in this solvent and the ICT reaction time of 0.5 ps is equal to the reciprocal of the sum of the forward and backward ICT rate constants 1/(k(a) + k(d)). In the photostationary S(0) → S(n) absorption spectrum of NP4CN in n-hexane and MeCN, an additional CT absorption band appears, absent in the sum of the spectra of its electron donor (D) and acceptor (A) subgroups carbazole and benzonitrile. This CT band is located at an energy of ∼4000 cm(-1) lower than for N-phenylcarbazole (NPC), due to the larger electron affinity of the benzonitrile moiety of NP4CN than the phenyl subunit of NPC. The fluorescence spectrum of NP4CN in n-hexane at 25 °C mainly consists of a structured LE emission, with a small ICT admixture, indicating that a LE → ICT reaction just starts to occur under these conditions. In di-n-pentyl ether (DPeE) and di-n-butyl ether (DBE), a LE emission is found upon cooling at the high-energy edge of the ICT fluorescence band, caused by the onset of dielectric solvent relaxation. This is not the case in more polar solvents, such as diethyl ether (DEE) and MeCN, in which a structureless ICT emission band fully overlaps the strongly quenched LE

  10. LeCroy MQT300A - charge to time converter

    SciTech Connect

    Yamrone, B.; Roberts, K.; Kelly, J.

    1997-12-31

    The MQT300A was developed to offer high resolution (12 bit) and wide dynamic range (18 bit) with reasonable cost, high density and fast conversion time (< 10 {mu}s). The reduced conversion time has allowed its first users the option to choose whether or not to develop a fast clear strategy as part of their trigger system. It can also be used for chamber-mounted applications allowing compact digital data cabling to the remote TDC. The MQT300A is a custom development produced in collaboration with the BELLE collaboration at KEK and the CLEO group at Cornell. In this collaboration Cornell and KEK were partners with LeCroy in both the specification and evaluation of the first prototypes. LeCroy has been responsible for the remainder of the project. The MQT300A is available in LeCroy modules and also as a separate monolithic. The MQT300A was designed to take advantage of the latest generation of multi-hit TDCs, for example the LeCroy 1877S FASTBUS ADC. The 1877S was specifically optimized to improve conversion time and to intelligently minimize the data record size for the MQT300A application. A prototype part was designed and fabricated using a custom bipolar process. Though fully functional it did not meet several important performance specifications. A reiteration with significant redesign of two sections resulted in a part that meets all specifications. The unique encoding algorithm used to provide auto-ranging has had a U.S. patent allowed. The part is now commercially available in production volumes.

  11. Le sumatriptan intranasal pour la migraine chez les enfants

    PubMed Central

    Goldman, Ran D.; Meckler, Garth D.

    2015-01-01

    Résumé Question Je vois de plus en plus d’enfants et d’adolescents qui souffrent de céphalées pouvant se classer dans la catégorie des migraines. J’ai fait des lectures sur le sumatriptan par voie intranasale comme thérapie abortive. Est-ce un traitement efficace? Réponse La migraine aiguë chez les enfants et les adolescents est fréquente et difficile à traiter. Le sumatriptan intranasal est une option sûre et généralement efficace pour les enfants et les adolescents. La dose actuellement recommandée est de 20 mg pour les enfants qui pèsent plus de 40 kg et de 10 mg pour ceux dont le poids se situe entre 20 et 39 kg. Il faudrait faire des études de plus grande envergure pour contrecarrer les limitations des échantillons de petite taille et mieux comprendre la faible concentration plasmique et les effets placebo observés dans les études jusqu’à présent.

  12. Le kyste hydatique du cordon spermatique: une localisation exceptionnelle

    PubMed Central

    Hamdane, Mohamed Moncef; Bougrine, Fethi; Msakni, Issam; Dhaoui-Ghozzi, Amen; Bouziani, Ammar

    2011-01-01

    L’ hydatidose est une anthropo-zoonose due au développement chez l'homme de la forme larvaire du taenia Echinococcus granulosis. La plupart des kystes hydatiques se localisent dans le foie et les poumons. Le kyste hydatique du cordon spermatique est extrêmement rare avec seulement 4 cas rapportés dans la littérature. Les auteurs rapportent dans cet article un nouveau cas d'hydatidose du cordon spermatique. Il s'agissait d'un homme de 40 ans qui consultait pour des douleurs scrotales évoluant depuis huit mois. L'examen clinique a mis en évidence une tuméfaction mobile, inguino-scrotale, droite. L’échographie testiculaire a objectivé une hernie inguinale droite associée à deux kystes épididymaires bilatéraux. Le patient a été opéré pour cure de son hernie avec découverte en per-opératoire d'un kyste du cordon spermatique qui a été réséqué. L'examen anatomopathologique a conclu à une hydatidose du cordon spermatique. PMID:22384304

  13. Airborne pollen and spores of León (Spain)

    NASA Astrophysics Data System (ADS)

    Fernández-González, Delia; Suarez-Cervera, María; Díaz-González, Tomás; Valencia-Barrera, Rosa María

    1993-06-01

    A qualitative and quantitative analysis of airborne pollen and spores was carried out over 2 years (from September 1987 to August 1989) in the city of León. Slides were prepared daily using a volumetric pollen trap, which was placed on the Faculty of Veterinary Science building (University of León) 12m above ground-level. Fifty-one pollen types were observed; the most important of these were: Cupressaceae during the winter, Pinus and Quercus in spring, and Poaceae, Leguminosae and Chenopodiaceae in the summer. The results also showed the existence of a rich mould spore assemblage in the atmosphere. The group of Amerospores ( Penicillium, Aspergillus and Cladosporium) as well as Dictyospores ( Alternaria) were the most abundant; Puccinia was common in the air in August. Fluctuations in the total pollen and spores m3 of air were compared with meteorological parameters (temperature, relative humidity and rainfall). From the daily sampling of the atmosphere of León, considering the maximum and minimum temperature and duration of rainfall, the start of the pollen grain season was observed generally to coincide with a rise in temperature in the absence of rain.

  14. Le tetanos chez le grand enfant dans un hôpital pédiatrique à Yaoundé, Cameroun

    PubMed Central

    Ntoto Njiki Kinkela, Mina; Nguefack, Félicitée; Mbassi Awa, Hubert; Chelo, David; Enyama, Dominique; Mbollo Kobela, Marie; Koki Ndombo, Paul Olivier

    2012-01-01

    Le tétanos est évitable par la vaccination, mais peut survenir en cas d'une immunisation incomplète. Nous avons mené une étude sur les dossiers médicaux des enfants admis pour tétanos entre 2008-2009 au Centre Mère et Enfant de la Fondation Chantal BIYA à Yaoundé. Le but était d'analyser les circonstances de survenue et les manifestations cliniques du tétanos chez le grand enfant, afin de proposer des stratégies de prévention adaptées au contexte camerounais. Le statut vaccinal était inconnu chez un patient, les autres (80%) n'avaient pas reçu de rappel vaccinal. Les portes d'entrée étaient les plaies aux membres, l'une était secondaire à une injection médicamenteuse. Tous ont présenté le tétanos généralisé. Le décès était survenu chez un patient. Le tétanos n'est pas rare chez le grand enfant au Cameroun. Il se dégage ainsi la problématique des rappels vaccinaux. PMID:22514771

  15. Solution NMR and calorimetric analysis of Rem2 binding to the Ca2+ channel β4 subunit: a low affinity interaction is required for inhibition of Cav2.1 Ca2+ currents.

    PubMed

    Xu, Xingfu; Zhang, Fangxiong; Zamponi, Gerald W; Horne, William A

    2015-05-01

    Rem, Rad, Kir/Gem (RGK) proteins, including Rem2, mediate profound inhibition of high-voltage activated Ca(2+) channels containing intracellular regulatory β subunits. All RGK proteins bind to voltage-gated Ca(2+) channel β subunit (Cavβ) subunits in vitro, but the necessity of the interaction for current inhibition remains controversial. This study applies NMR and calorimetric techniques to map the binding site for Rem2 on human Cavβ4a and measure its binding affinity. Our experiments revealed 2 binding surfaces on the β4 guanylate kinase domain contributing to a 156 ± 18 µM Kd interaction: a hydrophobic pocket lined by 4 critical residues (L173, N261, H262, and V303), mutation of any of which completely disrupted binding, and a nearby surface containing 3 residues (D206, L209, and D258) that when individually mutated decreased affinity. Voltage-gated Ca(2+) channel α1A subunit (Cav2.1) Ca(2+) currents were completely inhibited by Rem2 when co-expressed with wild-type Cavβ4a, but were unaffected by Rem2 when coexpressed with a Cavβ4a site 1 (L173A/V303A) or site 2 (D258A) mutant. These results provide direct evidence for a low-affinity Rem2/Cavβ4 interaction and show definitively that the interaction is required for Cav2.1 inhibition. PMID:25563298

  16. Le médicament générique au Maroc: le point de vue du consommateur

    PubMed Central

    Zaoui, Sanaa; Hakkou, Farid; Filali, Houda; Khabal, Youssef; Tazi, Illias; Mahmal, Lahoucine

    2013-01-01

    Introduction Le médicament générique est souvent une origine de préjugés négatifs et de méfiance chez les professionnels de santé et les patients. Ceci pourrait être dû à plusieurs facteurs entre autre le manque des connaissances du patient sur ces médicaments. Le but de notre étude était d’évaluer l'information du consommateur sur les médicaments génériques et apprécier leur utilisation de ces médicaments. Méthodes Il s'agit d'une étude transversale réalisée de Janvier à Mars 2010 auprès de 251 sujets. Un questionnaire comprenant dix questions fermées a été utilisé. Les questions concernaient l’évaluation des connaissances sur les médicaments génériques, les sources d'information, le degré de confiance et d'information des patients sur ces médicaments. Une analyse descriptive simple des différentes variables a été réalisée. Résultats Dans notre étude, 126 sujets (50,2%) ont répondu connaître les médicaments génériques. Parmi eux, 52,3% les utilisaient et 67,4% estimaient qu'ils étaient insuffisamment informés sur ces médicaments. Les cadres supérieurs et les étudiants ont représenté la catégorie qui utilisait le plus les médicaments génériques (respectivement dans 40,9% et 25,7%) et qui était la mieux informée (respectivement dans 61,9% et 23,81%). Le faible coût a été la principale motivation d'utilisation du médicament générique (93,9%). Les médias ont représenté la première source d'information (59,5%). Après sensibilisation, 88,8% des sujets qui ne connaissaient pas le médicament générique ont été favorable à son utilisation. Conclusion Une promotion efficace par une politique d'information soutenue auprès des consommateurs et par des mesures incitatrices à la prescription et à la délivrance du générique par les médecins et les pharmaciens, pourront améliorer l'utilisation de ces médicaments dans notre pays. PMID:24009794

  17. La prévention des infections par le virus respiratoire syncytial

    PubMed Central

    Robinson, JL

    2011-01-01

    RÉSUMÉ L’infection par le virus respiratoire syncytial (VRS) est la principale cause d’infections des voies respiratoires inférieures chez les jeunes enfants. Le palivizumab, un anticorps monoclonal anti-VRS, réduit le taux d’hospitalisation des enfants à haut risque mais est très coûteux. Le présent document de principes remplace les trois précédents documents de principes de la Société canadienne de pédiatrie sur le sujet et est mis à jour principalement pour traiter des récentes modifications aux lignes directrices de l’American Academy of Pediatrics dans le contexte canadien. Il contient une analyse des publications ainsi que des recommandations au sujet de l’utilisation du palivizumab chez les enfants à haut risque

  18. Le consentement libre et éclairé aux soins en psychiatrie

    PubMed Central

    Neilson, Grainne; Chaimowitz, Gary

    2015-01-01

    Résumé Le patient a le droit d’être informé sur les soins de santé qui lui sont proposés et de participer activement à la prise de décisions relativement à ces soins. Le respect de la dignité et de l’autonomie de la personne passe par le respect de son droit de prendre des décisions à propos de ses soins psychiatriques, notamment de refuser un traitement, pour autant qu’elle soit apte à prendre des décisions. Il importe que le psychiatre connaisse les fondements éthiques du consentement libre et éclairé et les exigences prévues par le droit en cette matière, y compris la jurisprudence. Le consentement n’est pas immuable, pouvant changer avec le temps, au fil de l’évolution des conditions et des circonstances. Par conséquent, le consentement doit être un processus continu.

  19. Le gingembre contre la nausée et les vomissements de la grossesse

    PubMed Central

    Lindblad, Adrienne J.; Koppula, Sudha

    2016-01-01

    Question clinique Le gingembre peut-il traiter la nausée et les vomissements de la grossesse? Résultats Durant le premier trimestre, le gingembre soulagerait la nausée et les vomissements de quelque 4 points sur une échelle de 40 points, ou éliminerait les vomissements chez 1 femme sur 3 au jour 6. L’étude la plus vaste ne laisse croire à aucune hausse des malformations congénitales ou de la mortinatalité, mais les études de moins grande envergure laissent croire le contraire.

  20. 4. Historic American Buildings Survey, Arthur W. LeBoeuf, Photographer, 1937 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Arthur W. LeBoeuf, Photographer, 1937 DETAIL OF WINDOW BREAKING INTO PEDIMENT. - First Congregational Church, 301 Benefit Street, Providence, Providence County, RI

  1. The JPL 'long ephemeris', DE102/LE51

    NASA Technical Reports Server (NTRS)

    Standish, E. M., Jr.

    1983-01-01

    A number of applications exist in astronomical research for planetary and lunar ephemerides covering an extended length of time. This paper discusses such a set of ephemerides, DE102/LE51, produced at JPL, covering the time 1411 B.C. to 3001 A.D. The ephemerides are dynamically self-consistent, in that the equations of motion were integrated simultaneously. They also represent the most accurately known positions covering such a time span. They have already been used by a number of different users in a variety of different applications.

  2. Snow in Castile-León: trends and variability

    NASA Astrophysics Data System (ADS)

    Merino, A.; Campos, L.; López, L.; García-Ortega, E.; Sánchez, J. L.; Marcos, J. L.; Guerrero-Higueras, A. M.

    2012-04-01

    The location of Castile and León, inside the Iberian Peninsula, in the Northwestern quadrant, determines, in large measure, the climatic conditions of its territory, granting it very characteristic traits, mostly in the mountainous areas. It is important to note that during a large part of the year, the region is under the influence of Jet Stream, and thus, gives way to very diverse dynamic situations, which turn into different and heterogeneous types of weather. So, in many areas of the region, especially in the most elevated areas, these synoptic and mesoscale situations generate snow precipitation. We should point out that snowfall is one of the principal meteorological risks of Castile and León. Thus, on average, in some mountainous areas there are more than 40 events of snowfall registered annually, with the month of January being the month in which the highest frequency of snowfall appears. The social repercussions of this snowfall are represented in the isolation of places, essentially mountainous, highways being blocked, increase in traffic accidents, etc. As proof of this, it is this type of episode that receives ample coverage by the media, which has a linear relationship with the social perception of risk. As such, the objective of the current work is to analyze the annual trend of days with snow in the different meteorological stations pertaining to AEMET placed in the Community. The period of study is from 1960-2010. Additionally, we have also evaluated trends in annual days of freezing temperature and annual absolute minimum temperature, with the objective of facilitating a meteorological interpretation of the trends obtained on days with snowfall. Finally, the results show that in the majority of stations, a significant negative trend in days with snowfall and annual days with freezing temperatures, and a positive trend in annual absolute minimum temperatures. However, we observed variability in the different regions in the area of study

  3. Le genre Tunga Jarocki, 1838 (Siphonaptera : Tungidae). I – Taxonomie, phylogénie, écologie, rôle pathogène

    PubMed Central

    Beaucournu, J.-C.; Degeilh, B.; Mergey, T.; Muñoz-Leal, S.; González-Acuña, D.

    2012-01-01

    Pour la première fois, les 12 espèces actuellement décrites dans le genre Tunga sont étudiées sur le plan de la taxonomie et de la répartition. Divers aspects de leur biologie et leur rôle pathogène sont également envisagés, et en particulier leur phylogénie, leur chorologie, leur phénologie, leur sexe-ratio et leurs dermecos. PMID:23193514

  4. Characterization of a new bacteriocin from Lactobacillus plantarum LE5 and LE27 isolated from ensiled corn.

    PubMed

    Amortegui, Jairo; Rodríguez-López, Alexander; Rodríguez, Deicy; Carrascal, Ana K; Alméciga-Díaz, Carlos J; Melendez, Adelina del P; Sánchez, Oscar F

    2014-04-01

    Bacteriocins are low molecular peptides with antimicrobial activity, which are of great interest as food bio-preservatives and for treating diseases caused by pathogenic bacteria. In this study, we present the characterization of bacteriocins produced by Lactobacillus plantarum LE5 and LE27 isolated from ensiled corn. Bacteriocins were purified through ammonium sulfate precipitation and double dialysis by using 12- and 1-kDa membranes. Bacteriocins showed activity against Listeria innocua, Listeria monocytogenes, and Enteroccocus faecalis. Molecular weight was estimated through Tricine-SDS-PAGE and overloading the gel onto Mueller-Hinton agar seeded with L. monocytogenes, showing an inhibition zone between 5 and 10 kDa. NanoLC-MS/MS analysis allowed the identification of UPF0291 protein (UniProtKB/Swiss-Prot Q88VI7), which is also presented in other lactic acid bacteria without assigned function. Ab initio modeling showed it has an α-helix-rich structure and a large positive-charged region. Bacteriocins were stable between 4 and 121 °C and pH 2 and 12, and the activity was inhibited by SDS and proteases. Mode of action assay suggests that the bacteriocin causes of target microorganism. Taken together, these results describe a possible new class IIa bacteriocin produced by L. plantarum, which has a wide stability to physicochemical conditions, and that could be used as an alternative for the control of foodborne diseases. PMID:24532444

  5. Characterizing the secondary hydration shell on hydrated myoglobin, hemoglobin, and lysozyme powders by its vitrification behavior on cooling and its calorimetric glass-->liquid transition and crystallization behavior on reheating.

    PubMed Central

    Sartor, G; Hallbrucker, A; Mayer, E

    1995-01-01

    For hydrated metmyoglobin, methemoglobin, and lysozyme powders, the freezable water fraction of between approximately 0.3-0.4 g water/g protein up to approximately 0.7-0.8 g water/g protein has been fully vitrified by cooling at rates up to approximately 1500 K min-1 and the influence of cooling rate characterized by x-ray diffractograms. This vitreous but freezable water fraction started to crystallize at approximately 210 K to cubic ice and at approximately 240 K to hexagonal ice. Measurements by differential scanning calorimetry have shown that this vitreous but freezable water fraction undergoes, on reheating at a rate of 30 K min-1, a glass-->liquid transition with an onset temperature of between approximately 164 and approximately 174 K, with a width of between approximately 9 and approximately 16 degrees and an increase in heat capacity of between approximately 20 and approximately 40 J K-1 (mol of freezable water)-1 but that the glass transition disappears upon crystallization of the freezable water. These calorimetric features are similar to those of water imbibed in the pores of a synthetic hydrogel but very different from those of glassy bulk water. The difference to glassy bulk water's properties is attributed to hydrophilic interaction and H-bonding of the macromolecules' segments with the freezable water fraction, which thereby becomes dynamically modified. Abrupt increase in minimal or critical cooling rate necessary for complete vitrification is observed at approximately 0.7-0.8 g water/g protein, which is attributed to an abrupt increase of water's mobility, and it is remarkably close to the threshold value of water's mobility on a hydrated protein reported by Kimmich et al. (1990, Biophys. J. 58:1183). The hydration level of approximately 0.7-0.8 g water/g protein is approximately that necessary for completing the secondary hydration shell. PMID:8599674

  6. Use of Mobile Testing System PeLe for Developing Language Skills

    ERIC Educational Resources Information Center

    Titova, Svetlana

    2015-01-01

    One of the objectives of this paper is to investigate the pedagogical impact of both the mobile testing system PeLe (Norway, HiST) and the enquiry-based learning approach on language skills development in the context of mobile-assisted learning. The research aims to work out a methodological framework of PeLe implementation into the language…

  7. CoLeMo: A Collaborative Learning Environment for UML Modelling

    ERIC Educational Resources Information Center

    Chen, Weiqin; Pedersen, Roger Heggernes; Pettersen, Oystein

    2006-01-01

    This paper presents the design, implementation, and evaluation of a distributed collaborative UML modelling environment, CoLeMo. CoLeMo is designed for students studying UML modelling. It can also be used as a platform for collaborative design of software. We conducted formative evaluations and a summative evaluation to improve the environment and…

  8. MODeLeR: A Virtual Constructivist Learning Environment and Methodology for Object-Oriented Design

    ERIC Educational Resources Information Center

    Coffey, John W.; Koonce, Robert

    2008-01-01

    This article contains a description of the organization and method of use of an active learning environment named MODeLeR, (Multimedia Object Design Learning Resource), a tool designed to facilitate the learning of concepts pertaining to object modeling with the Unified Modeling Language (UML). MODeLeR was created to provide an authentic,…

  9. Understanding the recognition of Lewis X by anti-Le(x) monoclonal antibodies.

    PubMed

    Moore, Christopher J; Auzanneau, France-Isabelle

    2013-10-24

    The recognition of the Le(x) antigen by the anti-Le(x) monoclonal antibody (mAb) SH1 was studied by ELISA using a panel of 4″-modified Le(x) analogues. We confirmed that these analogues maintained the stacked conformation adopted by natural Le(x) antigen using 1D ROESY experiments and measuring intramolecular distances. Our binding studies show that the 4-OH″ of galactose behaves as an H-bond donor to an electronegative amino acid side chain in the SH1 binding site. While removal of this H-bond leads to reduced inhibition, disturbing the hydrophobic α face of the β-galactosyl residue leads to complete loss of binding to SH1. We compared our results to the crystal structure of the Fab fragment of anti-Le(x) mAb 291-2G3-A complexed with Le(x) (PDB entry 1UZ8 ). While no H-bond involving the 4-OH″ was described, hydrophobic interactions between a tryptophan residue and the β-galactoside α face are observed. We conclude that the hydrophobic α face that is uniquely displayed by β-galactosyl residues is essential to the recognition of the Le(x) antigen by anti-Le(x) antibodies. PMID:24059473

  10. The NASA-LeRC wind turbine sound prediction code

    NASA Technical Reports Server (NTRS)

    Viterna, L. A.

    1981-01-01

    Since regular operation of the DOE/NASA MOD-1 wind turbine began in October 1979 about 10 nearby households have complained of noise from the machine. Development of the NASA-LeRC with turbine sound prediction code began in May 1980 as part of an effort to understand and reduce the noise generated by MOD-1. Tone sound levels predicted with this code are in generally good agreement with measured data taken in the vicinity MOD-1 wind turbine (less than 2 rotor diameters). Comparison in the far field indicates that propagation effects due to terrain and atmospheric conditions may be amplifying the actual sound levels by about 6 dB. Parametric analysis using the code has shown that the predominant contributions to MOD-1 rotor noise are: (1) the velocity deficit in the wake of the support tower; (2) the high rotor speed; and (3) off column operation.

  11. Design of Multidimensional Shinnar-Le Roux RF Pulses

    PubMed Central

    Ma, Chao; Liang, Zhi-Pei

    2014-01-01

    Purpose To generalize the conventional Shinnar-Le Roux (SLR) method for the design of multidimensional RF pulses. Methods Using echo-planar gradients, the multidimensional RF pulse design problem was converted into a series of 1D polynomial design problems. Each of the 1D polynomial design problems was solved efficiently. B0 inhomogeneity compensation and design of spatial-spectral pulses were also considered. Results The proposed method was used to design 2D excitation and refocusing pulses. The results were validated through Bloch equation simulation and experiments on a 3.0 T scanner. Large-tip-angle, equiripple-error, multidimensional excitation was achieved with ripple levels closely matching the design specifications. Conclusion The conventional SLR method can be extended to design multidimensional RF pulses. The proposed method achieves almost equiripple excitation errors, allows easy control of the tradeoff among design parameters, and is computationally efficient. PMID:24578212

  12. The ERDA/LeRC Photovoltaic Systems Test Facility

    NASA Technical Reports Server (NTRS)

    Forestieri, A. F.

    1978-01-01

    The ERDA/LeRC Photovoltaic Systems Test Facility (STF) provides a vital support function to the overall ERDA National Solar Photovoltaic Program. It allows preliminary investigation and checkout of components, subsystems, and complete photovoltaic systems before installation in actual service. The STF can also be used to determine optimum system configurations and operating modes. A facility description is presented, taking into account the solar cell array, the energy storage equipment, the power conditioning equipment, electric utility distribution network and loads, and instrumentation and data acquisition systems. Safety procedures which have been set up for maintenance and inspection of the solar array are discussed. Attention is also given to a number of investigations regarding the effect of environmental factors on solar cell array operation.

  13. An Overview-NASA LeRC Structures Program

    NASA Technical Reports Server (NTRS)

    Zaretsky, Erwin V.

    1997-01-01

    The Structures and Acoustics Division of the NASA Lewis Research Center has its genesis dating back to 1943. It has been an independent Division at Lewis since 1979. Its two primary capabilities are performance and life analysis of static and dynamic systems such as those found in aircraft and spacecraft propulsion systems and experimental verification of these analyses. Research is conducted in-house, through university grants and contracts, and through cooperative programs with industry. Our work directly supports NASA's Advanced Subsonic Technology (AST), Smart Green Engine, Fast Quiet Engine, High-Temperature Materials and Processing (HiTEMP), Hybrid Hyperspeed Propulsion, Rotorcraft, High-Speed Research (HSR), and Aviation Safety Program (AvSP). A general overview is given discussing these programs and other technologies that are being developed at NASA LeRC.

  14. Dysfonctionnements radio-induits du transport colique chez le rat

    NASA Astrophysics Data System (ADS)

    François, A.; Lebrun, F.; Ksas, B.; Aigueperse, J.; Gourmelon, P.; MacNaughton, W. K.; Griffiths, N. M.

    1998-04-01

    The symptom commonly associated with whole body irradiation is diarrhoea, a still quite obscure phenomenon, which leads to decreased chance of cure of irradiated people. The aim of this study was to provide evidence for dysfunction of intestinal water and electrolyte transport regulation by the enteric nervous system after exposure to ionising radiation. This study shows decreased capacity of enteric nervous system to influence colonic transport 3days after irradiation, correlated to a diminished response to a neurotransmitter: serotonin. Radio-induced diarrhea may result from epithelial structural injury but also from impaired regulatory processes of intestinal transport. L'un des symptômes majeurs d'une irradiation corporelle totale ou abdominale est l'apparition de diarrhées, dont les causes sont encore mal connues, et qui mettent en jeu le pronostique vital de l'individu irradié. Cette étude vise à mettre en évidence l'atteinte de la régulation du transport intestinal d'eau et d'électrolytes par les rayonnements ionisants. On observe une diminution de la capacité du système nerveux entérique à influencer le transport colique 3jours après irradiation, corrélée à une diminution de la réponse épithéliale à un neurotransmetteur : la sérotonine. Les diarrhées radio-induites résulteraient d'une atteinte structurelle de l'épithélium mais également des processus de régulation du transport intestinal.

  15. Neptune's Discovery: Le Verrier, Adams, and the Assignment of Credit

    NASA Astrophysics Data System (ADS)

    Sheehan, William

    2011-01-01

    As one of the most significant achievements of 19th century astronomy, the discovery of Neptune has been the subject of a vast literature. A large part of this literature--beginning with the period immediately after the optical discovery in Berlin--has been the obsession with assigning credit to the two men who attempted to calculate the planet's position (and initially this played out against the international rivalry between France and England). Le Verrier and Adams occupied much different positions in the Scientific Establishments of their respective countries; had markedly different personalities; and approached the investigation using different methods. A psychiatrist and historian of astronomy tries to provide some new contexts to the familiar story of the discovery of Neptune, and argues that the personalities of these two men played crucial roles in their approaches to the problem they set themselves and the way others reacted to their stimuli. Adams had features of high-functioning autism, while Le Verrier's domineering, obsessive, orderly personality--though it allowed him to be immensely productive--eventually led to serious difficulties with his peers (and an outright revolt). Though it took extraordinary smarts to calculate the position of Neptune, the discovery required social skills that these men lacked--and thus the process to discovery was more bumbling and adventitious than it might have been. The discovery of Neptune occurred at a moment when astronomy was changing from that of heroic individuals to team collaborations involving multiple experts, and remains an object lesson in the sociological aspects of scientific endeavor.

  16. Overexpression of the tomato pollen receptor kinase LePRK1 rewires pollen tube growth to a blebbling mode

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The tubular growth of a pollen tube cell is crucial for the sexual reproduction of flowering plants. LePRK1 is a pollen-specific and plasma membrane–localized receptor-like kinase from tomato (Solanum lycopersicum). LePRK1 interacts with another receptor, LePRK2, and with KINASE PARTNER PROTEIN (KPP...

  17. Les fluctuations supraconductrices dans le compose praseodyme-cerium-oxyde de cuivre

    NASA Astrophysics Data System (ADS)

    Renaud, Jacques

    Ce travail etudie les fluctuations supraconductrices dans le compose supraconducteur a haute temperature critique dope aux electrons Pr2-xCe xCuO4+delta. La technique utilisee pour sonder ces fluctuations est le transport electrique DC dans le plan ab. Il s'agit, a notre connaissance, de la premiere etude de ce type dans la classe generale des supraconducteurs a haute temperature critique dopes aux electrons et, plus particulierement, dans Pr2-xCe xCuO4+delta. De plus, l'etude est effectuee pour trois regimes de dopage, soit sous-dope x = 0.135, dopage optimal x = 0.15 et surdope x = 0.17. Les echantillons etudies sont des couches minces d'epaisseur plus grande que 100 nm crues par ablation laser. Les mesures electriques DC effectuees dans ce travail sont la resistance en reponse lineaire et les courbes IV en reponse non lineaire en fonction de la temperature. La mise en oeuvre experimentale de ces mesures a necessite une grande attention au filtrage et aux effets de chauffage a haut courant. Nous montrons que, sans cette attention, les donnees experimentales sont toujours erronees dans le regime pertinent pour nos echantillons. Les resultats pour le dopage optimal x = 0.15 sont expliques de facon tres convaincante dans le cadre de fluctuations purement 2D. D'abord, le regime des fluctuations gaussiennes est tres bien decrit par le modele d'Aslamazov-Larkin en deux dimensions. Ensuite, le regime de fluctuations critiques, se trouvant a plus basse temperature que le regime gaussien, est tres bien decrit par la physique 2D de Kosterlitz-Thouless. Dans cette analyse, les deux regimes ont des temperatures critiques coherentes entre elles, ce qui semble confirmer ce scenario 2D. Une analyse des donnees dans le cadre de fluctuations 3D est exploree mais donne des conclusions incoherentes. Les resultats pour les autres dopages sont qualitativement equivalents avec le dopage optimal et permettent donc une explication purement 2D. Par contre, contrairement au dopage optimal

  18. Approximation auto-coherente a deux particules, pseudogap et supraconductivite dans le modele de Hubbard attractif

    NASA Astrophysics Data System (ADS)

    Allen, Steve

    2000-10-01

    Dans cette these nous presentons une nouvelle methode non perturbative pour le calcul des proprietes d'un systeme de fermions. Notre methode generalise l'approximation auto-coherente a deux particules proposee par Vilk et Tremblay pour le modele de Hubbard repulsif. Notre methode peut s'appliquer a l'etude du comportement pre-critique lorsque la symetrie du parametre d'ordre est suffisamment elevee. Nous appliquons la methode au probleme du pseudogap dans le modele de Hubbard attractif. Nos resultats montrent un excellent accord avec les donnees Monte Carlo pour de petits systemes. Nous observons que le regime ou apparait le pseudogap dans le poids spectral a une particule est un regime classique renormalise caracterise par une frequence caracteristique des fluctuations supraconductrices inferieure a la temperature. Une autre caracteristique est la faible densite de superfluide de cette phase demontrant que nous ne sommes pas en presence de paires preformees. Les resultats obtenus semblent montrer que la haute symetrie du parametre d'ordre et la bidimensionalite du systeme etudie elargissent le domaine de temperature pour lequel le regime pseudogap est observe. Nous argumentons que ce resultat est transposable aux supraconducteurs a haute temperature critique ou le pseudogap apparait a des' temperatures beaucoup plus grandes que la temperature critique. La forte symetrie dans ces systemes pourraient etre reliee a la theorie SO(5) de Zhang. En annexe, nous demontrons un resultat tout recent qui permettrait d'assurer l'auto-coherence entre les proprietes a une et a deux particules par l'ajout d'une dynamique au vertex irreductible. Cet ajout laisse entrevoir la possibilite d'etendre la methode au cas d'une forte interaction.

  19. LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels

    PubMed Central

    Yin, Shijin; Luo, Jialie; Qian, Aihua; Yu, Weihua; Hu, Hongzhen

    2014-01-01

    Background and PurposeRetinoids, through their activation of retinoic acid receptors (RARs) and retinoid X receptors, regulate diverse cellular processes, and pharmacological intervention in their actions has been successful in the treatment of skin disorders and cancers. Despite the many beneficial effects, administration of retinoids causes irritating side effects with unknown mechanisms. Here, we demonstrate that LE135 [4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid], a selective antagonist of RARβ, is a potent activator of the capsaicin (TRPV1) and wasabi (TRPA1) receptors, two critical pain-initiating cation channels. Experimental ApproachWe performed to investigate the excitatory effects of LE135 on TRPV1 and TRPA1 channels expressed in HEK293T cells and in dorsal root ganglia neurons with calcium imaging and patch-clamp recordings. We also used site-directed mutagenesis of the channels to determine the structural basis of LE135-induced activation of TRPV1 and TRPA1 channels and behavioural testing to examine if pharmacological inhibition and genetic deletion of the channels affected LE135-evoked pain-related behaviours. Key ResultsLE135 activated both the capsaicin receptor (TRPV1) and the allyl isothiocyanate receptor (TRPA1) heterologously expressed in HEK293T cells and endogenously expressed by sensory nociceptors. Mutations disrupting the capsaicin-binding site attenuated LE135 activation of TRPV1 channels and a single mutation (K170R) eliminated TRPA1 activity evoked by LE135. Intraplantar injection of LE135 evoked pain-related behaviours. Both TRPV1 and TRPA1 channels were involved in LE135-elicited pain-related responses, as shown by pharmacological and genetic ablation studies. Conclusions and ImplicationsThis blocker of retinoid acid signalling also exerted non-genomic effects through activating the pain-initiating TRPV1 and TRPA1 channels. PMID:24308840

  20. Synthesis, characterization, phase diagrams and superconducting and normal state magnetic properties of La{sub 2{minus}x}Sr{sub x}CuO{sub 4} (0 {le} x {le} 0.08) and electrochemically oxidized La{sub 2{minus}x}Sr{sub x}CuO{sub 4+{delta}} (0 {le} x {le} 0.33, 0 {le} {delta} {le} 0.12)

    SciTech Connect

    Chou, F.

    1993-08-01

    La{sub 2{minus}x}Sr{sub x}CuO{sub 4} (0 {le} x {le} 0.15) can all be intercalated with oxygen by a novel electrochemical oxidation method. Bulk superconductivity is found with an onset {Tc} {approx} 40 K for the whole range 0.01 {le} x {le} 0.15; for x = 0.25 and 0.33, the electrochemical oxidation did not improve the superconducting properties. The magnetic susceptibility {chi}(T = 50--320 K) data for La{sub 2}CuO{sub 4.11} and La{sub 1.92}Sr{sub 0.08}CuO{sub 4.07} are nearly identical with those of conventionally prepared La{sub 1.85}Sr{sub 0.15}CuO{sub 4}, indicating that the hole doping level (p) in the CuO{sub 2} planes of the three compounds is nearly the same. Combined thermogravimetric analysis and iodometric titration experiments indicate that part of the intercalated oxygen has a formal valence close to {minus}1. The maximum doped-hole concentration in the CuO{sub 2} planes that can be achieved from combined Sr-doping and electrochemical oxygen doping for 0 {le} x {le} 0.15 is p {approx} 0.16 holes/formula unit. Oxygen can also intercalate into single crystal La{sub 2}CuO{sub 4} through a slow electrochemical oxidation process. The required low current and long time for the charging process reflects that the oxygen intercalation for a single crystal is limited by its small specific surface area and long diffusion distance. The anisotropic superconducting, magnetic and transport properties are summarized and compared with those of polycrystalline La{sub 2}CuO{sub 4+{delta}} as well as of YBa{sub 2}Cu{sub 3}O{sub 7{minus}{delta}} and La{sub 2{minus}x}Sr{sub x}CuO{sub 4} single crystals. The single crystal La{sub 2}CuO{sub 4+{delta}} has a maximum {Tc} {approx} 40 K, which is lower than that ({Tc} {approx} 42--45) of the corresponding polycrystalline samples. The magnetic phase diagram of La{sub 2{minus}x}Sr{sub x}CuO{sub 4} in the antiferromagnetic (AF) regime (0 {le} x {le} 0.02) has been derived from {sup 139}La NQR studies from 4 to 250 K.

  1. STIL, a peculiar molecule from styles, specifically dephosphorylates the pollen receptor kinase LePRK2 and stimulates pollen tube growth in vitro

    Technology Transfer Automated Retrieval System (TEKTRAN)

    BACKGROUND: LePRK1 and LePRK2 are two pollen receptor kinases localized to the plasma membrane, where they are present in a high molecular weight complex (LePRK complex). LePRK2 is phosphorylated in mature and germinated pollen, but is dephosphorylated when pollen membranes are incubated with tomato...

  2. 1. Historic American Buildings Survey, Arthur W. LeBoeuf, Photographer, 1937 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Arthur W. LeBoeuf, Photographer, 1937 DETAIL OF MANTEL. - John Mason House (Mantel), Weybosset Street (moved to Rhode Island School of Design), Providence, Providence County, RI

  3. 5. Former P&LE tracks (now CSXT) adjacent to trestle towards ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Former P&LE tracks (now CSXT) adjacent to trestle towards west. - Monongahela Connecting Railroad Company, Y Trestle, South side of Monongahela River between Thirty-fourth & Twenty-ninth Streets, Pittsburgh, Allegheny County, PA

  4. A Multistep Equilibria-Redox-Complexation Demonstration to Illustrate Le Chatelier's Principle.

    ERIC Educational Resources Information Center

    Berger, Tomas G.; Mellon, Edward K.

    1996-01-01

    Describes a process that can be used to illustrate a number of chemical principles including Le Chatelier's principle, redox chemistry, equilibria versus steady state situations, and solubility of species. (JRH)

  5. An Overhead Demonstration of Some Descriptive Chemistry of the Halogens and LeChatelier's Principle.

    ERIC Educational Resources Information Center

    Hansen, Robert C.

    1988-01-01

    Describes a demonstration procedure using controlled reduction potentials to predict observed color changes which are then experimentally verified. Demonstrates the usefulness of this procedure in helping students understand LeChatelier's principle and the solubilit rule "like dissolves like." (CW)

  6. General parameter relations for the Shinnar-Le Roux pulse design algorithm.

    PubMed

    Lee, Kuan J

    2007-06-01

    The magnetization ripple amplitudes from a pulse designed by the Shinnar-Le Roux algorithm are a non-linear function of the Shinnar-Le Roux A and B polynomial ripples. In this paper, the method of Pauly et al. [J. Pauly, P. Le Roux, D. Nishimura, A. Macovski, Parameter relations for the Shinnar-Le Roux selective excitation pulse design algorithm, IEEE Transactions on Medical Imaging 10 (1991) 56-65.] has been extended to derive more general parameter relations. These relations can be used for cases outside the five classes considered by Pauly et al., in particular excitation pulses for flip angles that are not small or 90 degrees. Use of the new relations, together with an iterative procedure to obtain polynomials with the specified ripples from the Parks-McClellan algorithm, are shown to give simulated slice profiles that have the desired ripple amplitudes. PMID:17408999

  7. Le volvulus gastrique idiopathique aigu: à propos d'une nouvelle observation

    PubMed Central

    Abdelilah, Mouhsine; Jihad, Anzaoui; Rachid, Bouchentouf

    2013-01-01

    Le volvulus gastrique est une rotation anormale de l'estomac autour de son axe. La forme aiguë constitue une urgence chirurgicale. Le diagnostic est souvent retardé en raison d'une symptomatologie fréquemment non spécifique. Des signes respiratoires tels la dyspnée et le hoquet peuvent révéler cette pathologie. Les auteurs rapportent une nouvelle observation de volvulus gastrique aigu chez un adolescent de 17 ans, diagnostiqué par la tomodensitométrie, et confirmé par une intervention chirurgicale. Le traitement est chirurgical et consiste à détordre et fixer l'estomac pour prévenir la récidive. PMID:23503200

  8. [Mr. Wang Le-ting: a master of acupuncture].

    PubMed

    Niu, Xue-Song; Wang, Fan

    2012-11-01

    Mr. WANG Le-ting attaches great importance to accurate differentiation of syndromes, strict selection of acupoints, technique and direction of needle insertion, clear reinforcing and reducing methods after the appearance of needling sensations, proper opportunities of manipulations as well as needle withdrawal techniques, and reasonable application of acupuncture and moxibustion respectively. The above mentioned principles are known as his "5 agreements". He emphasizes that the selection of acupoints should be "in accordance with both the meridians and the accurate location of the points", and "needling sensation is necessary for each point". He holds that the back-shu points of the five-zang organs and Geshu (BL 17) can be adopted for patient with deficiency of qi, blood, yin and yang. In the aspect of acupoint theory, he insists the accurate location of Xuanzhong (GB 39). He also adjusts the locations of Huatuo Jiaji (EX-B 2) points, and finds the location of the new Dubi (ST 35). For easier applications, he divides the functions of acupoints into different schools of qi, blood, cold, heat, deficiency, excess, wind and dampness. And 41 combinations of acupoints are also invented as innovation. He is always strict to his students, instructing and influencing them by his own words and deeds. He is always conscientious and meticulous, which benefit immensely his followers, and remains a lot of precious experiences for the later generations. PMID:23214000

  9. Le Fort's procedure--an option for the aged.

    PubMed

    Chaudhury, Nilanjana; Sen, Mainak

    2011-03-01

    The changing demographics of the world's population will result in an increasing prevalence of pelvic organ prolapse and consequently a greater demand for healthcare services related to it. The objective of the study is to evaluate the efficacy of partial colpocleisis (Le Fort's operation) in a selected group of patients who are: (a) Not desirous of sexual function, (b) very elderly medically fragile, hence not fit for anaesthesia, (c) not fit for prolonged lithotomy position. After careful selection of cases 10 patients were included in the study from August 2005 to March 2006. USG(TVS) and cervical cytology were done to exclude any pathology. Partial colpocleisis was done under local anaesthesia with delayed absorbable sutures which closed the vagina from inside leaving drainage tracts on either side for egress of blood and cervicovaginal secretions postoperatively. A levator plication and high perineorrhaphy was also done. All patients(100%) had symptomatic relief. Only one patient (10%) had postoperative bleeding. Rest all had uneventful recovery. No recurrence of prolapse or SUI has developed till date. Operative time on average was 15 minutes. Hospital stay was 24 hours. Peroperative bleeding was negligible. Partial colpocleisis is an excellent operation for the treatment of pelvic organ prolapse (POP) for very selective group of patients. The advantage of the procedure lies in its simple technique, permanent cure, symptomatic relief and minimal surgical risk. Hence it can be done as a day care procedure at a very low cost. PMID:22010590

  10. Portevin-Le Chatelier effect and Tsallis nonextensive statistics

    NASA Astrophysics Data System (ADS)

    Iliopoulos, A. C.; Nikolaidis, N. S.; Aifantis, E. C.

    2015-11-01

    In this paper, we estimate Tsallis' entropic index q ≡qstat (stat denotes stationary states) for various stress serration time series of Cu-15%Al alloys corresponding to different deformation temperatures and types (A, B, C) of Portevin-Le Chatelier (PLC) bands. Tsallis statistical analysis is also conducted on experimental data derived from correlation diagrams focusing on PLC type C bands' spatial organization at the surface of various specimens. The results concerning the stress serrations analysis reveal the non-Gaussian (Tsallis q-Gaussian), nonextensive, sub-additive, character of the underlying dynamics of the PLC type-A bands (q > 1) indicating dynamics at the edge of chaos, with global long range correlations and power law scaling. Similarly, for PLC type B bands, a Tsallis q-Gaussian, non-extensive, super-additive, statistical profile was found with q < 1, while for the PLC type C bands, a near Boltzmann-Gibbs (BG) statistical character was verified indicating Gaussian dynamics with short (weak) range correlations. Finally, Tsallis q-index for the spatial data of PLC type C bands was found above unity (q > 1) indicating that type C bands are not randomly nucleated in the specimen (e.g. yielding a Gaussian distribution) but there exist spatial coupling and long range deformation correlations in the PLC type C bands spatial localization.

  11. Nanobridge SQUIDs as calorimetric inductive particle detectors

    NASA Astrophysics Data System (ADS)

    Gallop, John; Cox, David; Hao, Ling

    2015-08-01

    Superconducting transition edge sensors (TESs) have made dramatic progress since their invention some 65 years ago (Andrews et al 1949 Phys. Rev. 76 154-155 Irwin and Hilton 2005 Topics Appl. Phys. 99 63-149) until now there are major imaging arrays of TESs with as many as 7588 separate sensors. These are extensively used by astronomers for some ground-breaking observations (Hattori et al 2013 Nucl. Instrum. Methods Phys. Res. A 732 299-302). The great success of TES systems has tended to overshadow other superconducting sensor developments. However there are other types (Sobolewski et al 2003 IEEE Trans. Appl. Supercond. 13 1151-7 Hadfield 2009 Nat. Photonics 3 696-705) which are discussed in papers within this special edition of the journal. Here we describe a quite different type of detector, also applicable to single photon detection but possessing possible advantages (higher sensitivity, higher operating temperature) over the conventional TES, at least for single detectors.

  12. Calorimetric measurement of energy of ultrasonic cleaners

    SciTech Connect

    Harding, W.B.

    1994-11-01

    The development of a calorimeter that measured the power within an ultrasonic cleaning tank is presented. The principle involved is explained. Several types of calorimeter that were tested are described. Measurement of the power in an ultrasonic cleaner permits: (1) comparing different ultrasonic cleaners; (2) monitoring the performance of a specific cleaner; (3) measuring the distribution of power in a cleaning tank, and (4) evaluating the effects of process variables on the power.

  13. Facteurs de risque de l'infection par le VIH dans le district de santé de Meyomessala au Cameroun

    PubMed Central

    Mbopi-Keou, Francois-Xavier; Nguefack-Tsague, Georges; Kalla, Ginette Claude Mireille; Abessolo, Stéphanie Abo'o; Angwafo, Fru; Muna, Walinjom

    2014-01-01

    Introduction L'objectif de ce travail était de déterminer les facteurs de risque de l'infection par le VIH dans le district de santé de Meyomessala (Région du Sud) au Cameroun. Méthodes Il s'agissait d'une étude transversale, descriptive et analytique qui s'est déroulée de Février à Mai 2011. Pour cette étude, nous avons obtenu une clairance éthique. Résultats L’échantillon était constitué de 315 participants dont 181 (57,46%) hommes et 134 (42,54%) femmes. L’âge moyen était de 24,5±8ans (extrême: 15-45ans). Quarante personnes (40) étaient séropositifs, soit une prévalence de l'infection par le VIH de 12,7%. Cette prévalence augmentait significativement (p = 0) avec le nombre de partenaires occasionnels au cours des douze derniers mois, allant de 2,7% chez ceux n'ayant eu aucun partenaire occasionnel à 21,25% chez ceux ayant plus de trois partenaires occasionnels (RC = 9,72; IC = 1,27-74,14; P = 0,03). le fait d’être âgé entre 20 et 24 ans (RC = 4,88; IC = 1,74-13,67; p = 0), avoir plus de trois partenaires sexuels au cours des douze derniers mois (RC = 9,72; IC = 1,27-74,14; p = 0,03), avoir les rapports sexuels avec les prostitués (RC = 2,86; IC = 1,42-5,76; p = 0), avoir eu le chlamydia (RC = 3,00; IC = 1,07-8,39; p = 0,04), avoir eu la syphilis (RC = 3,35; IC = 1,57-7,14; p = 0), avoir des avantages sociaux lors du premier rapport sexuel (RC = 2,57; IC = 1,03-6,43; p = 0,04) constituaient des potentiels facteurs de risque du VIH. Conclusion Il apparait urgent d'intensifier les campagnes de sensibilisation au risque d'infection par le VIH et les maladies sexuellement transmissibles dans le district de santé de Meyomessala PMID:25419299

  14. 'Le roi le veult'.

    PubMed

    Sholl, W T

    1997-06-14

    Following the fiftieth anniversary of the National Health Service Act 1946, I make the case in this article that professional provision of health care must remain the property of the citizen under common law and must not become a commodity that is bought and sold by third parties, including the state. PMID:9217334

  15. Facteurs déterminants le regret après ligature tubaire

    PubMed Central

    Boufettal, Houssine; Mahdaoui, Sakher; Samouh, Naïma

    2014-01-01

    Introduction La ligature tubaire peut générer regret. Le but de cette étude est d’étudier le vécu après la stérilisation ainsi que le regret et ses facteurs de risque. Méthodes Il s'agit d'une étude rétrospective chez 52 femmes stérilisées entre 2004 et 2010. Résultats Vingt cinq (48%) femmes avaient regretté la réalisation de la ligature tubaire. La moyenne d’âge était de 40,5 ans. Le temps consacré aux explications était très court dans tous les cas. Trois quart des femmes n’était pas au courant des complications de la ligature tubaire. Le regret était dû au facteur religieux (23%), aux algies pelviennes (11,5%), au désir d'autres enfants (9,6%) ou à la prise de connaissance d'autres moyens contraceptifs (3,9%). Conclusion Un certains nombre de facteurs de risque de regret de la ligature tubaire sont retrouvés dans la littérature, comme dans notre série, dont l’âge, le désir de procréer, l'information incomplète, le délai de réflexion et le facteur religieux. PMID:25309644

  16. La tuberculose pulmonaire et le tabac: à propos de 100 cas

    PubMed Central

    Janah, Hicham; Souhi, Hicham; Kouissmi, Hatim; Marc, Karima; Zahraoui, Rachida; Benamor, Jouda; Soualhi, Mona; Bourkadi, Jamal Eddine

    2014-01-01

    Le tabagisme et la tuberculose sont deux enjeux majeurs de santé publique au niveau mondial, en particulier dans les pays émergents. Pour déterminer les particularités cliniques, radiologiques, bactériologiques et thérapeutiques de la tuberculose pulmonaire chez les sujets tabagiques nous avons mené une étude prospective au service de phtisiologie de l'hôpital Moulay Youssef sur une période de 10 mois, portant sur 100 nouveaux cas de tuberculose pulmonaire, répartis en 2 groupes, 50 patients tabagiques: Groupe A et 50 patients non tabagiques: Groupe B. Tous nos patients étaient de sexe masculin, l’âge moyen était de 41 ans ± 12 chez le groupe A et de 36 ans ± 16 chez le groupe B. Le délai de consultation était plus long chez les tabagiques, la médiane était de 60j (30; 98) contre 40j (30; 60), la symptomatologie clinique était variable chez les deux groupes, dominée par les expectorations chez les tabagiques 96% contre 60%. Les lésions radiologiques étaient similaires chez les deux groupes ainsi que la charge bacillaire. Tous les patients ont été mis sous traitement antituberculeux. Après un mois du traitement, la Bacilloscopie était négative chez 50% du groupe A contre 66% chez le groupe B. la régression des lésions radiologiques était similaire chez les deux groupes. Le retard diagnostique et le retard de négativation des frottis sont les principales particularités de la tuberculose pulmonaire du sujet tabagique. Le sevrage tabagique doit faire partie intégrante de la prise en charge des patients atteints de tuberculose. PMID:25821545

  17. SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes

    PubMed Central

    Shen, Yue; Stracquadanio, Giovanni; Wang, Yun; Yang, Kun; Mitchell, Leslie A.; Xue, Yaxin; Cai, Yizhi; Chen, Tai; Dymond, Jessica S.; Kang, Kang; Gong, Jianhui; Zeng, Xiaofan; Zhang, Yongfen; Li, Yingrui; Feng, Qiang; Xu, Xun; Wang, Jun; Wang, Jian; Yang, Huanming; Boeke, Jef D.; Bader, Joel S.

    2016-01-01

    Synthetic chromosome rearrangement and modification by loxP-mediated evolution (SCRaMbLE) generates combinatorial genomic diversity through rearrangements at designed recombinase sites. We applied SCRaMbLE to yeast synthetic chromosome arm synIXR (43 recombinase sites) and then used a computational pipeline to infer or unscramble the sequence of recombinations that created the observed genomes. Deep sequencing of 64 synIXR SCRaMbLE strains revealed 156 deletions, 89 inversions, 94 duplications, and 55 additional complex rearrangements; several duplications are consistent with a double rolling circle mechanism. Every SCRaMbLE strain was unique, validating the capability of SCRaMbLE to explore a diverse space of genomes. Rearrangements occurred exclusively at designed loxPsym sites, with no significant evidence for ectopic rearrangements or mutations involving synthetic regions, the 99% nonsynthetic nuclear genome, or the mitochondrial genome. Deletion frequencies identified genes required for viability or fast growth. Replacement of 3′ UTR by non-UTR sequence had surprisingly little effect on fitness. SCRaMbLE generates genome diversity in designated regions, reveals fitness constraints, and should scale to simultaneous evolution of multiple synthetic chromosomes. PMID:26566658

  18. [LE cells in synovial fluid: prevalence and diagnostic usefulness in rheumatic diseases].

    PubMed

    Puszczewicz, Mariusz; Białkowska-Puszczewicz, Grazyna

    2010-01-01

    This study was undertaken to determine the prevalence of LE cells in synovial fluid and their importance for the diagnosis of rheumatic disease. Synovial fluid was obtained from 631 patients: 31 with systemic lupus erythematosus (SLE), 337 with rheumatoid arthritis (RA), 4 with Still's disease, 9 with systemic scleroderma (SS), 27 with the overlap syndrome (RA/SLE), 132 with ankylosing spondylitis (AS), 57 with Reiter's syndrome, and 34 with psoriatic arthritis (PA). The fluid was centrifuged, precipitate smears were done and were May-Grünwald-Giemsa stained for cytologic assessment. The supernatant was collected for antinuclear antibody (ANA) testing. Physicochemical and serologic properties of the synovial fluid were routinely determined. All synovial fluids demonstrated signs of inflammation. The presence of LE cells was ascertained in five patients with SLE and nine patients with the overlap syndrome. In these cases, LE cells were accompanied by ANA. In addition, hematoxylin bodies were revealed in SLE patients. LE cells were observed in 2.6% of patients with RA but were not accompanied by ANA. Patients with SS, Still's disease, AS, Reiter's syndrome, and PA tested negative for LE cells. It appears from these results that LE cells are rarely present in the synovial fluid of patients with rheumatic diseases. In contrast, they occur in more than 40% of patients with the overlap syndrome and may thus be regarded as important for the diagnosis of this condition. PMID:21365954

  19. Architectural Kansei of ‘Wall’ in The Façade Design by Le Corbusier

    NASA Astrophysics Data System (ADS)

    Sendai, Shoichiro

    The purpose of this paper is to discuss the modern architect Le Corbusier's architectural Kansei (sensibility) on wall in site environment through the analysis of his façade design, using Œuvres complètes (1910-1965, 8 vols., Les éditions d'architecture, Artemis, Zurich) and Le Corbusier Archives (1982-1984, 32 vols., Garland Publishing, Inc. and Fondation Le Corbusier, New York, London, Paris). At first, I arrange five façade types, according to the explanation by Le Corbusier ; ‘fenêtre en longueur (strip window)’, ‘pan de verre (glass wall)’, ‘brise-soleil (sun-breaker)’, ‘loggia’ and ‘claustra’. Through the analysis of the relationship between these types and the design process of each building, we find that Le Corbusier's façade design includes the affirmation and the negation of the ‘wall’ at the same time. In fact, the nature of façade modification during design process is divers: increase in transparency, decrease in transparency and spatialization of façade. That means, Le Corbusier studied the environmental condition by these façade types, and tried to realize the phenomenal openness. This trial bases on the function of architectural Kansei as correspondence between body and environment beyond the physical design.

  20. SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes.

    PubMed

    Shen, Yue; Stracquadanio, Giovanni; Wang, Yun; Yang, Kun; Mitchell, Leslie A; Xue, Yaxin; Cai, Yizhi; Chen, Tai; Dymond, Jessica S; Kang, Kang; Gong, Jianhui; Zeng, Xiaofan; Zhang, Yongfen; Li, Yingrui; Feng, Qiang; Xu, Xun; Wang, Jun; Wang, Jian; Yang, Huanming; Boeke, Jef D; Bader, Joel S

    2016-01-01

    Synthetic chromosome rearrangement and modification by loxP-mediated evolution (SCRaMbLE) generates combinatorial genomic diversity through rearrangements at designed recombinase sites. We applied SCRaMbLE to yeast synthetic chromosome arm synIXR (43 recombinase sites) and then used a computational pipeline to infer or unscramble the sequence of recombinations that created the observed genomes. Deep sequencing of 64 synIXR SCRaMbLE strains revealed 156 deletions, 89 inversions, 94 duplications, and 55 additional complex rearrangements; several duplications are consistent with a double rolling circle mechanism. Every SCRaMbLE strain was unique, validating the capability of SCRaMbLE to explore a diverse space of genomes. Rearrangements occurred exclusively at designed loxPsym sites, with no significant evidence for ectopic rearrangements or mutations involving synthetic regions, the 99% nonsynthetic nuclear genome, or the mitochondrial genome. Deletion frequencies identified genes required for viability or fast growth. Replacement of 3' UTR by non-UTR sequence had surprisingly little effect on fitness. SCRaMbLE generates genome diversity in designated regions, reveals fitness constraints, and should scale to simultaneous evolution of multiple synthetic chromosomes. PMID:26566658

  1. Modelisation des proprietes electromagnetiques de metamateriaux a base de reseaux de fils ferromagnetiques

    NASA Astrophysics Data System (ADS)

    Boucher, Vincent

    The main objective of this work is to establish analytical expressions for the effective permittivity and permeability of metamaterials based on arrays of ferromagnetic conducting wires. Specifically, we consider the case of axially magnetized wires of radius ranging from 10 nm to 100 mum, which are excited in the microwave frequency range (1-- 100 GHz) by electric and magnetic fields parallel and perpendicular to the axis of the wires, respectively. We place special emphasis on evaluating the potential of these ferromagnetic wire arrays to produce, over the same frequency range, simultaneous magnetic-field-tuneable electric and magnetic responses. First, our method of derivation requires solving the problem of the scattering and absorption of an electromagnetic wave by an individual wire, so as to obtain the dipolar responses of its dynamic polarization and magnetization in the regime of arbitrary skin effect. These responses are then incorporated into our homogenization procedure, in order to yield general expressions for the effective permittivity and permeability of the array, which depend upon the gyromagnetic and metallic properties of the wires, the geometrical parameters of the array, and the interwire dipolar interactions. Our results show that the consideration of skin effect is greatly simplified by introducing kwa-dependent renormalized expressions for the wire intrinsic properties, where kw is the complex amplitude of the wave vector inside the wires of radius a. Our expression for the effective permeability tensor of the array is a gyrotropic tensor, with diagonal and off-diagonal components expressed compactly in terms of renormalized permeability components which account for electromagnetic retardation inside the wires. It must be emphasized that our explicit treatment of both gyrotropy and electromagnetic retardation constitutes an extension of existing models, which are restricted to considering only one or the other of these two aspects. We also describe how the effective permeability of dense arrays of nanowires can be exploited by using semi-isolated wires, that is, wires for which electrical continuity is not maintained at either of their ends. Such arrays then behave as effective magnetic insulators but no longer show magnetodielectric effects. Hence, we conclude that the conditions under which arrays of ferromagnetic wires exhibit effective permittivity and permeability that are simultaneously significant and tuneable by a static magnetic field tend to be mutually exclusive. Next, we apply our theoretical formalism to the study of the effective permeability of dense arrays of nanowires (i.e., characterized by negligible skin effect) embedded in a dielectric membrane. In these arrays, the individual wires exhibit a bistable response as a function of the static axial magnetic field, so that when the array is partially demagnetized, the wires split into two oppositely magnetized populations, the relative proportions of which can be adjusted by using minor hysteresis cycles. Further, the presence of these two populations strongly modifies the effective permeability of the array, which may then display two distinct absorption peaks. In order to validate our effective permeability model, broadband microstrip line ferromagnetic resonance measurements (1--40 GHz) have been performed on an array of Co94Fe5B1 nanowires, of average diameter 45 nm, embedded into an alumina membrane of average interpore distance 110 nm. These show that the complex permeability spectra extracted from the experimental data are generally in excellent agreement with the theoretical spectra. In particular, the model accounts well for the dependence of the shape, amplitude, position, and width of the two-peak permeability spectra as a function of the applied static magnetic field and the remanent magnetization of the array. Discrepancies observed when the peaks are close to each other are attributed to spatial fluctuations of the local interaction field, which are not accounted for in our model. (Abstract shortened by UMI.)

  2. Lymphome et grossesse: le point de vue de l'obstétricien, à propos de 2 cas

    PubMed Central

    Amourak, Sarah; Alaoui, Fatimazahra Fdili; Jayi, Sofia; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2014-01-01

    L'association lymphome et grossesse est une situation rare, mais non exceptionnelle, relevant de la coïncidence. Le lymphome vient en 4ème position des cancers rencontrés chez la femme enceinte, La clinique est trompeuse et inconstante, le diagnostic reste histologique et on distingue 2 types: lymphome malin hodgkinien (LMH) et le lymphome malin non hodgkinien (LMNH). Malgré le contexte de véritable urgence hématologique, la décision d'initier ou de différer le traitement est délicate, influencée par le type de lymphome, son extension et sa localisation, la répercussion organique, le degré de maturation f'tale, les risques obstétricaux et les valeurs éthiques, culturelles et religieuses de la patiente. Le traitement consiste essentiellement à une chimiothérapie. Le LH durant la grossesse est relativement moins agressif et d’évolution plus favorable que le LMNH. PMID:25883744

  3. Intrication de deux atomes en utilisant le blocage de Rydberg

    NASA Astrophysics Data System (ADS)

    Gaëtan, A.

    2010-12-01

    Considérons un système quantique constitué de deux sous-systèmes : on dit qu'il est dans un état intriqué s'il existe des corrélations quantiques entre les états de ces derniers. La compréhension et la mise en œuvre d'états intriqués ont de nombreuses applications (métrologie quantique, étude des systèmes fortement corrélés, traitement quantique de l'information, etc.) et constituent le contexte général de ce travail de thèse. Plus en détail, nous démontrons la réalisation d'un état intriqué de deux atomes neutres piégés indépendamment. Pour cela, nous exploitons le phénomène de blocage de Rydberg : lorsqu'on essaie d'exciter simultanément deux atomes séparés de quelques micromètres vers un état de Rydberg donné, la forte interaction entre atomes de Rydberg peut empêcher cette excitation simultanée. Dans ce cas, seul un des deux atomes est excité et l'on génère ainsi des corrélations quantiques entre les états des deux atomes, c'est-à-dire de l'intrication. Dans notre expérience, deux atomes de 87Rb dans l'état fondamental 5S1/2 sont piégés chacun dans une pince optique microscopique, à une distance relative de 4 micromètres. En réalisant des transitions entre l'état 5S1/2 et l'état de Rydberg 58D3/2 par des transitions à deux photons, nous obtenons un état intriqué des deux atomes dans les sous-niveaux |5S1/2, f = 1, mf = 1> et |5S1/2, f = 2, mf = 2>. Afin de quantifier l'intrication, nous mesurons la fidélité par rapport à l'état-cible en réalisant des transitions Raman entre ces deux sous-niveaux. La fidélité des paires d'atomes présentes à la fin de l'expérience est supérieure à la valeur seuil de 0,5, ce qui prouve la création d'un état intriqué.

  4. Évolution des lignes directrices sur le traitement de la dyslipidémie

    PubMed Central

    John Bosomworth, N.

    2014-01-01

    Résumé Objectif Comprendre comment les nouvelles lignes directrices sur la prise en charge du risque cardiovasculaire publiées par l’American Heart Association et l’American College of Cardiology (AHA-ACC) peuvent être interprétées et utilisées dans le contexte canadien. Sources des données Les lignes directrices de l’AHA-ACC ont été examinées, de même que toutes les références. Des recherches indépendantes dans PubMed ont été effectuées pour inclure l’ajout aux statines d’autres antihyperlipidémiants et l’emploi de calculatrices médicales visant à aider le patient à comprendre. Message principal Les nouvelles lignes directrices de l’AHA-ACC s’appuient sur les meilleures données probantes disponibles actuellement en matière de traitement de la dyslipidémie. Cela inclut le risque cardiovasculaire (CV) sur 10 ans comme seuil thérapeutique au lieu du taux de cholestérol des lipoprotéines de faible densité, de même que l’abandon des cibles thérapeutiques de lipoprotéines de faible densité. On met de plus en plus l’accent sur les interventions alimentaires et l’exercice, avec l’amorce d’un effort pour quantifier l’effet de ces interventions. Les statines constituent la principale intervention pharmacologique, et l’ajout d’autres médicaments pour accentuer la baisse lipidique n’est plus recommandé. En ce qui concerne l’application au Canada, les tables de risque de Framingham sont plus appropriées pour évaluer le risque que les équations de cohortes regroupées utilisées aux États-Unis. Les calculatrices du risque de maladie cardiovasculaire (MCV) devraient contenir de l’information sur l’âge cardiovasculaire et devraient pouvoir illustrer le risque et les interventions de rechange afin d’aider le patient à comprendre et de favoriser la prise de décision éclairée. Conclusion L’attention sur les meilleures données probantes concernant le risque CV peut simplifier le traitement de la

  5. le de l'hydrogène dans le procédé de purification du silicium par plasma thermique inductif

    NASA Astrophysics Data System (ADS)

    Erin, J.; Morvan, D.; Amouroux, J.

    1993-03-01

    The use of the thermal process for purification of silicon led to a material with the chemical purity required for phototovoltaic applications. In this paper, the various properties of ArH2 plasma mixtures are briefly reviewed and the effect of hydrogen percentage in an argon plasma used for melting and purifying silicon is pointed out. Physico-chemical analysis of the purified silicon showed that hydrogen diffused in the material and could passivate crystal defects by formation of stable chemical bonds such as Si-H. La technique de purification du silicium sous plasma thermique permet d'aboutir à un matériau de pureté chimique requise pour l'industrie photovoltaïque. Dans ce travail, nous soulignerons lele de l'hydrogène intervenant dans les propriétés du plasma en rappelant les caractéristiques des plasmas Ar-H2 utilisés pour fondre et purifier le silicium. Les caractéristiques physico-chimiques du silicium purifié montrent que l'hydrogène diffuse dans le matériau et est en mesure de cicatriser les défauts cristallins par formation de liaisons chimiques stables de type Si-H.

  6. Spectroscopic and calorimetric investigation of short and intermediate-range structures and energetics of amorphous SiCO, SiCN, and SiBCN polymer-derived ceramics

    NASA Astrophysics Data System (ADS)

    Widgeon, Scarlett J.

    Polymer-derived ceramics (PDCs) are a new class of amorphous ceramics in the Si-B-C-N system that are synthesized by the pyrolysis of silicon-based organic polymers. PDCs are lightweight and are resistant to creep, crystallization, and oxidation at temperatures near 1800 K making them ideal for a variety of high temperature applications. In spite of being X-ray amorphous, these materials display structural heterogeneity at the nanometer length scale. Their structure and resulting properties can be drastically altered by the utilization of preceramic polymers with differing chemistry and architectures. Fundamental understanding of the atomic structure is critical in deciphering the structure-property relationships and ultimately in controlling their properties for specific engineering applications. The short-range atomic structure has been extensively investigated using a variety of techniques, however, the structures at length scales beyond next-nearest neighbors remained highly controversial. Here we report the results of a spectroscopic and calorimetric study of short and intermediate -range structure and energetic of SiOC and SiBCN PDCs derived from a wide variety of precursors. SiOC PDCs with different carbon contents were synthesized from polysiloxane precurors and their structures were studied using high-resolution 13C and 29Si nuclear magnetic resonance (NMR) spectroscopy. The results suggest that these PDCs consists of a continuous mass fractal backbone of corner-shared SiC xO4-x tetrahedral units with "voids" occupied by sp 2-hybridized graphitic carbon. The oxygen-rich SiCxO 4-x units are located at the interior of this backbone with a mass fractal dimension of ~ 2.5, while the carbon-rich units occupy the two-dimensional interface between the backbone and the free carbon nanodomains. Such fractal topology is expected to give rise to unusual mechanical and transport properties characteristic of fractal percolation networks. For example, elastic moduli and

  7. Tumeur de vessie chez le sujet jeune: à propos de 36 cas

    PubMed Central

    Statoua, Mouad; El Ghanmi, Jihad; Karmouni, Tarik; El Khader, Khalid; Koutani, Abdellatif; Attya, Ahmed Iben

    2014-01-01

    Les tumeurs de vessie sont rares avant 40 ans et ne représentent que 1 à 4% de l'ensemble de ces tumeurs. Notre étude s'est intéressée au profil épidémiologique, caractère histologique ainsi que le profil évolutif. Nous avons réalisé une étude retrospective sur une durée de 10 ans entre mars 2004 et mars 2014, nous avons traité 850 patients pour tumeur de vessie dont 36 était âgé de moins de 40 ans. Le diagnostic était posé devant des arguments cliniques, radiologiques et endoscopiques, la cystoscopie avec résection tumorale a précisé la nature histologique et son grading ainsi que le degré d'infiltration. 23 patients avaient une tumeur de vessie non infiltrant le muscle et 13 avaient une tumeur infiltrant le muscle. Le taux de récidive global est de l'ordre de 36,4%, 22% pour la tranche d’âge 20-30 ans et 46% pour la tranche d’âge 31-40 ans. Le risque de progression et de décès est respectivement de 8% et de 6,1%. Il ressort que les tumeurs superficielles ont une meilleure évolution chez les sujets de moins de 30 ans. Les tumeurs infiltrantes sont plus fréquentes et souvent évoluées suggérant un potentiel évolutif particulier. Leur pronostic est fonction du stade tumoral, sans corrélation avec l’âge. PMID:26113886

  8. A novel sialyl LeX expression score as a potential prognostic tool in colorectal cancer

    PubMed Central

    2012-01-01

    Background Treatment decisions in colorectal cancer subsequent to surgery are based mainly on the TNM system. There is a need to establish novel prognostic markers based on the molecular characterization of tumor cells. Evidence exists that sialyl LeX expression is correlated with an unfavorable outcome in colorectal cancer. The aim of this study was to establish a simple sialyl LeX staining score and to determine a potential correlation with the prognosis in a series of advanced colorectal carcinoma patients. Methods In order to implement routine use of sialyl LeX immunohistology, we established a new, easily reproducible score and defined a cutoff which discriminated groups with better or worse outcome, respectively. We then correlated sialyl LeX expression of 215 UICC stage III and IV patients with disease-free and cancer-related survival. Results A five-stage score could be established based on automated immunohistochemical stainings. Using a statistical model, we calculated a cutoff to discriminate between weak and strong staining positivity of sialyl LeX. Patients with strong positive specimens had a worse cancer-related survival (P = 0.004) but no difference was observed for disease-free survival (P = 0.352). Conclusions These results demonstrate a strong correlation between high sialyl LeX-expression in colorectal carcinomas and cancer-related survival. Our highly standardized and easy-to-use staining score is suitable for routine use and hence it could be recommended to evaluate sialyl LeX-expression as part of the standard histopathological analysis of colorectal carcinomas and to validate the score prospectively based on a larger population. PMID:22621806

  9. Effets du stress familial lié au diabète sur le contrôle glycémique chez les jeunes diabétiques de type 1

    PubMed Central

    Tsiouli, Elina; Alexopoulos, Evangelos C.; Stefanaki, Charikleia; Darviri, Christina; Chrousos, George P.

    2013-01-01

    Objectif Examiner la façon dont le stress familial influence le contrôle glycémique chez les patients diabétiques de moins de 18 ans. Sources des données Une recherche des études pertinentes publiées depuis 1990 a été réalisée dans PubMed et Scopus à l'aide des mots-clés suivants en anglais: diabetes type 1, glycemic control, family stress, family conflict et family function. Sélection des études La recension initiale a permis de cerner un total de 1 478 articles. La synthèse finale portrait sur 6 études de cohortes, 3 études transversales et 1 étude qualitative dans lesquelles le stress familial était évalué à l'aide d'instruments de mesure des conflits spécifiquement reliés au diabète et le contrôle glycémique était mesuré en fonction de l'hémoglobine glycosylée. Synthèse Dans la plupart des études, il existait une corrélation négative entre le stress familial et le contrôle glycémique des patients. Le bon fonctionnement familial était fortement relié à un bon contrôle glycémique des patients, tandis que les conflits familiaux étaient associés à un mauvais contrôle glycémique. Les familles dont la situation socioéconomique était défavorisée, celles ayant des adolescents atteints de diabète et les familles monoparentales étaient plus enclines à vivre un stress relié au diabète et étaient, par conséquent, plus susceptibles de connaître un moins bon contrôle glycémique. Conclusion Les interventions psychologiques thérapeutiques et les programmes éducatifs peuvent aider à atténuer le stress familial relié au diabète et amélioreront probablement le contrôle glycémique.

  10. Pertinence de l'implantation de la filiere granule de bois pour le Quebec

    NASA Astrophysics Data System (ADS)

    Tremblay, Stephan

    Les spécialistes avancent que le marché mondial de l'énergie en forte demande et en offre limitée nécessitera bientôt toutes les formes d'énergie disponibles. Le granulé de bois est une forme de bioénergie principalement utilisée pour le chauffage des bâtiments et pourrait être davantage considéré dans l'offre énergétique du Québec. Comme le Québec est un territoire où il fait froid et donc susceptible de pouvoir se tourner vers cette forme d'énergie, l'objectif de ce mémoire est d'en analyser les avantages. Pour ce faire, nous commencerons par démontrer la croissance des besoins énergétiques sur les plans national et international et dresser un portrait des différentes formes d'énergies consommées au Québec. Puisque la majorité des Québécois chauffent leurs bâtiments à l'hydroélectricité, nous analyserons à travers le plan d'approvisionnement d'Hydro-Québec le portrait de la production et de la consommation de cette forme d'énergie renouvelable. Cela nous permettra de constater le défi face à la gestion de surplus importants, sauf pendant la période hivernale, et ce faisant, l'obligation de la société d'État d'utiliser davantage ses centrales au gaz ou de se tourner vers l'importation de l'électricité. Dans la même lignée, un regard sera porté sur les perspectives d'utilisation de l'hydroélectricité sur les plans de la production d'aluminium, de l'exportation et de l'utilisation dans l'électrification des transports au Québec. Cette analyse se fera dans l'objectif de s'interroger sur la pertinence d'utiliser cette source d'énergie dans le chauffage plutôt que dans des secteurs plus créateurs de richesse. Nous poserons ensuite l'hypothèse que le granulé de bois pourrait être un bon substitut à une autre forme d'énergie utilisée dans le chauffage, soit le mazout. Avant de dresser un portrait de ce combustible fossile, nous ferons celui de la production et de la consommation de granulés sur les plans r

  11. Le naevus bleu cellulaire atypique du poignet: à propos d'un cas et revue de la literature

    PubMed Central

    Boussakri, Hassan; Roux, Jean Luc; Durand, Luc; Elibrahimi, Abdelhalim; Elmrini, Abdelmajid

    2014-01-01

    Le naevus bleu cellulaire atypique est une entité pathologique rare et sa localisation au niveau du poignet est exceptionnelle. Il est Considéré comme une Variante à des caractéristiques intermédiaires entre le naevus bleu cellulaire typique et le naevus bleu malin, dont l’évolution est incertaine. Le but de notre travail est d'attirer l'attention sur cette variété lésionnelle rare et de discuter les diagnostiques différentiels, ainsi que décrire les aspects histologique et les options thérapeutiques possibles. PMID:25426206

  12. Le modele de Hubbard bidimensionnel a faible couplage: Thermodynamique et phenomenes critiques

    NASA Astrophysics Data System (ADS)

    Roy, Sebastien

    Une etude systematique du modele de Hubbard en deux dimensions a faible couplage a l'aide de la theorie Auto-Coherente a Deux Particules (ACDP) dans le diagramme temperature-dopage-interaction-sauts permet de mettre en evidence l'influence des fluctuations magnetiques sur les proprietes thermodynamiques du systeme electronique sur reseau. Le regime classique renormalise a temperature finie pres du dopage nul est marque par la grandeur de la longueur de correlation de spin comparee a la longueur thermique de de Broglie et est caracterisee par un accroissement drastique de la longueur de correlation de spin. Cette croissance exponentielle a dopage nul marque la presence d'un pic de chaleur specifique en fonction de la temperature a basse temperature. Une temperature de crossover est alors associee a la temperature a laquelle la longueur de correlation de spin est egale a la longueur thermique de de Broglie. C'est a cette temperature caracteristique, ou est observee l'ouverture du pseudogap dans le poids spectral, que se situe le maximum du pic de chaleur specifique. La presence de ce pic a des consequences sur l'evolution du potentiel chimique avec le dopage lorsque l'uniformite thermodynamique est respectee. Les contraintes imposees par les lois de la thermodynamique font en sorte que l'evolution du potentiel chimique avec le dopage est non triviale. On demontre entre autres que le potentiel chimique est proportionnel a la double occupation qui est reliee au moment local. Par ailleurs, une derivation de la fonction de mise a l'echelle de la susceptibilite de spin a frequence nulle au voisinage d'un point critique marque sans equivoque la presence d'un point critique quantique en dopage pour une valeur donnee de l'interaction. Ce point critique, associe a une transition de phase magnetique en fonction du dopage a temperature nulle, induit un comportement non trivial sur les proprietes physiques du systeme a temperature finie. L'approche quantitative ACDP permet de

  13. Modelisation frequentielle de la permittivite du beton pour le controle non destructif par georadar

    NASA Astrophysics Data System (ADS)

    Bourdi, Taoufik

    Le georadar (Ground Penetrating Radar (GPR)) constitue une technique de controle non destructif (CND) interessante pour la mesure des epaisseurs des dalles de beton et la caracterisation des fractures, en raison de ses caracteristiques de resolution et de profondeur de penetration. Les equipements georadar sont de plus en plus faciles a utiliser et les logiciels d'interpretation sont en train de devenir plus aisement accessibles. Cependant, il est ressorti dans plusieurs conferences et ateliers sur l'application du georadar en genie civil qu'il fallait poursuivre les recherches, en particulier sur la modelisation et les techniques de mesure des proprietes electriques du beton. En obtenant de meilleures informations sur les proprietes electriques du beton aux frequences du georadar, l'instrumentation et les techniques d'interpretation pourraient etre perfectionnees plus efficacement. Le modele de Jonscher est un modele qui a montre son efficacite dans le domaine geophysique. Pour la premiere fois, son utilisation dans le domaine genie civil est presentee. Dans un premier temps, nous avons valide l'application du modele de Jonscher pour la caracterisation de la permittivite dielectrique du beton. Les resultats ont montre clairement que ce modele est capable de reproduire fidelement la variation de la permittivite de differents types de beton sur la bande de frequence georadar (100 MHz-2 GHz). Dans un deuxieme temps, nous avons montre l'interet du modele de Jonscher en le comparant a d'autres modeles (Debye et Debye-etendu) deja utilises dans le domaine genie civil. Nous avons montre aussi comment le modele de Jonscher peut presenter une aide a la prediction de l'efficacite de blindage et a l'interpretation des ondes de la technique GPR. Il a ete determine que le modele de Jonscher permet de donner une bonne presentation de la variation de la permittivite du beton dans la gamme de frequence georadar consideree. De plus, cette modelisation est valable pour differents

  14. Quatrième conférence consensuelle sur le diagnostic et le traitement de la démence

    PubMed Central

    Moore, Ainsley; Patterson, Christopher; Lee, Linda; Vedel, Isabelle; Bergman, Howard

    2014-01-01

    Résumé Objectif Revoir les stratégies diagnostiques de la maladie d’Alzheimer, actualiser les recommandations concernant le traitement des symptômes de démence et proposer une approche thérapeutique à la démence d’apparition précoce et d’évolution rapide. Composition du comité Des spécialistes et des délégués de diverses régions du Canada et représentant diverses disciplines pertinentes ont discuté et se sont mis d’accord sur les révisions à apporter aux lignes directrices de 2006. Méthodologie On a eu recours au système GRADE (grading of recommendations, assessment, development, and evaluation) pour évaluer le consensus concernant les recommandations, lequel était défini comme suit : lorsque 80 % ou plus des participants ont voté en faveur de la recommandation. La cote des données probantes est rapportée lorsque cela est possible. Rapport important pour les médecins de famille, malgré les progrès effectués dans les domaines des biomarqueurs liquidiens et de la neuro-imagerie, le diagnostic de démence au Canada demeure fondamentalement clinique. De nouveaux critères cliniques essentiels de diagnostic de la maladie d’Alzheimer en reconnaissent dorénavant les formes moins fréquentes et non amnestiques. La démence précoce, une affection rare, mais importante, devrait inciter les médecins à aiguiller les patients vers un spécialiste ayant accès à des conseillers en génétique. La démence d’évolution rapide, mal définie dans la littérature, faciliterait le dépistage de cette affection rare, mais importante. Les inhibiteurs de la cholinestérase sont maintenant indiqués pour le traitement d’affections autres que la maladie d’Alzheimer. Des lignes directrices concernant l’arrêt du traitement, lesquelles n’existaient pas auparavant, sont également apparues. De nouvelles données probantes sur le recours à la mémantine, aux antidépresseurs et à d’autres agents psychotropes dans le traitement de la

  15. LeCDJ1, a chloroplast DnaJ protein, facilitates heat tolerance in transgenic tomatoes.

    PubMed

    Kong, Fanying; Deng, Yongsheng; Wang, Guodong; Wang, Jieru; Liang, Xiaoqing; Meng, Qingwei

    2014-01-01

    The roles of a tomato (Lycopersicon esculentum) chloroplast-targeted DnaJ protein (LeCDJ1) were investigated using wild-type (WT) and sense transgenic tomatoes. The LeCDJ1 expression was upregulated by 38 °C, 42 °C, 45 °C, NaCl, PEG, methyl viologen (MV) and hydrogen peroxide (H2O2), but not by 30 °C and 35 °C. Meanwhile, LeCDJ1 was involved in the response of plants to abscisic acid (ABA). Under heat stress, the sense plants showed better growth, higher chlorophyll content, lower malondialdehyde (MDA) accumulation and relative electrical conductivity (REC), and also less PSII photoinhibition than WT. Interestingly, the sense plants treated with streptomycin (SM), an inhibitor of organellar translation, still showed higher maximum photochemistry efficiency of PSII (Fv/Fm) and D1 protein levels than the SM-untreated WT, suggesting that the protective effect of LeCDJ1 on PSII was, at least partially, independent of D1 protein synthesis. Furthermore, the relatively lower superoxide radical (O2(•-)) and H2O2 levels in the sense plants were considered to be due to the higher ascorbate peroxidase (APX) and superoxide dismutase (SOD) activity, which seemed unlikely dependent on their transcription level. These results indicated that LeCDJ1 overexpression facilitated heat tolerance in transgenic tomatoes. PMID:24148796

  16. Amphibians and Reptiles of the state of Nuevo León, Mexico

    PubMed Central

    Lemos-Espinal, Julio A.; Smith, Geoffrey R.; Cruz, Alexander

    2016-01-01

    Abstract We compiled a check list of the herpetofauna of Nuevo León. We documented 132 species (23 amphibians, 109 reptiles), representing 30 families (11 amphibians, 19 reptiles) and 73 genera (17 amphibians, 56 reptiles). Only two species are endemic to Nuevo León. Nuevo León contains a relatively high richness of lizards in the genus Sceloporus. Overlap in the herpetofauna of Nuevo León and states it borders is fairly extensive. Of 130 native species, 102 are considered species of Least Concern in the IUCN red list, four are listed as Vulnerable, five are listed as Near Threatened, and four are listed as Endangered. According to SEMARNAT, 78 species are not of conservation concern, 25 are subject to Special Protection, 27 are Threatened, and none are listed as in Danger of Extinction. Given current threats to the herpetofauna, additional efforts to understand the ecology and status of populations in Nuevo León are needed. PMID:27408562

  17. Amphibians and Reptiles of the state of Nuevo León, Mexico.

    PubMed

    Lemos-Espinal, Julio A; Smith, Geoffrey R; Cruz, Alexander

    2016-01-01

    We compiled a check list of the herpetofauna of Nuevo León. We documented 132 species (23 amphibians, 109 reptiles), representing 30 families (11 amphibians, 19 reptiles) and 73 genera (17 amphibians, 56 reptiles). Only two species are endemic to Nuevo León. Nuevo León contains a relatively high richness of lizards in the genus Sceloporus. Overlap in the herpetofauna of Nuevo León and states it borders is fairly extensive. Of 130 native species, 102 are considered species of Least Concern in the IUCN red list, four are listed as Vulnerable, five are listed as Near Threatened, and four are listed as Endangered. According to SEMARNAT, 78 species are not of conservation concern, 25 are subject to Special Protection, 27 are Threatened, and none are listed as in Danger of Extinction. Given current threats to the herpetofauna, additional efforts to understand the ecology and status of populations in Nuevo León are needed. PMID:27408562

  18. Hypertension during chronic exposure to cold: Comparison between Sprague Dawley (SD) and Long Evans (LE) strains

    SciTech Connect

    Riesselmann, A.; Baron, A.; Fregly, M.J. )

    1991-03-11

    Hypertension accompanies chronic exposure of SD rats to cold (5-6C), including elevation of systolic, diastolic, and mean blood pressures and cardiac hypertrophy. The renin-angiotensin system may play an important role. Earlier studies suggested that the LE strain may have a decrease in angiotensin I converting enzyme (ACE) activity. Measurement of ACE activity in plasmas of SE and LE strains revealed that basal activity of ACE in the plasma of the LE strain was significantly less than that of the SD strain. A second study was carried out in which both strains were exposed to cold for 7 weeks. There were clear differences between strains. Rats of the SD strain had a significant elevation in their blood pressure; a significantly increased urinary output of norepinephrine (NE) and epinephrine (E); and significant increases in weights of heart, kidneys, adrenals, and brown adipose tissue (IBAT) compared to their controls maintained at 26C. In contrast, rats of the LE strain were less responsive to cold in that blood pressure failed to rise as sharply and to attain as high a level; NE and E outputs, as well as weights of heart and IBAT were significantly less than those of rats of the cold-treated SD strain. Thus, the lower ACE activity in plasma of LE strain, as well as a reduced secretion of catecholamines, may protect these rats against the rise of blood pressure characteristically observed when rats of the SD strain are exposed to cold.

  19. "Panic": the impact of Le Bon's crowd psychology on U.S. military thought.

    PubMed

    Bendersky, Joseph W

    2007-01-01

    The controversial crowd psychology of Gustave Le Bon has been both praised as an incisive contribution to social theory and also condemned as a doctrine of irrationality and mass manipulation associated with fascism. New archival documentation now demonstrates that Le Bon exercised significant influence on U.S. military thinking and practice through World War II. Army writings and officer training on morale, leadership, and battlefield psychology rested substantially on his theory of crowds, particularly regarding races and panic. Le Bon's racial psychology took on additional importance when the African-American 92 nd Infantry Division panicked during combat in Italy. This new evidence offers an excellent case study of the direct and enduring impact of a peculiar type of social psychology on the institutional culture of the army from the classrooms at the Army War College to the battlefield itself. PMID:17623871

  20. Aristides Leão: a birth centennial homage with comments on his spreading depression.

    PubMed

    Engelhardt, Eliasz; Gomes, Marleide da Mota

    2015-06-01

    The year of 2014 is the birth centenary of Aristides Azevedo Pacheco Leão (1914-1993), and also marks seventy years of the publication of his discovery of the novel electrophysiological phenomenon, named by him "spreading depression" (SD), soon designated "Leão's wave" or "Leão's spreading depression". This was a remarkable scientific milestone, and the author must be celebrated for this achievement, as the studies he triggered proceeded worldwide, with new concepts, as spreading depolarization, until the present days. Robust experimental and clinical evidence emerged to suggest that these and related electrophysiological phenomena are involved in the mechanisms of migraine aura, acute cerebrovascular diseases, traumatic brain injury, transient global amnesia, epileptic seizures, and their pathophysiological characteristics come to offer new therapeutic perspectives. He was a remarkable and complex personality, and the authors remit the readers to a paper where his personal life is contemplated. PMID:26083892

  1. Le syndrome d'Othello: un cas observé à Ouagadougou

    PubMed Central

    Kaboré, Bawindsongré Jean; Napon, Christian

    2013-01-01

    Les auteurs rapportent le premier cas de délire de jalousie encore décrit sous l'acronyme de syndrome d'Othello, à Ouagadougou. Il s'est agit d'un patient qui au décours d'un accident vasculaire cérébral ischémique constitué, a développé un délire de jalousie. Une revue de la littérature permet de comprendre que l'affection, rarement rapportée est de plus en plus décrite au décours de maladies neurologiques aigues ou chroniques, et que le lobe frontal joue vraisemblablement un rôle majeur. PMID:24570777

  2. Le conflit fémoro-acétabulaire et la coxarthrose

    PubMed Central

    Zhang, Charlie; Li, Linda; Forster, Bruce B.; Kopec, Jacek A.; Ratzlaff, Charles; Halai, Lalji; Cibere, Jolanda; Esdaile, John M.

    2015-01-01

    Objectif Expliquer la présentation clinique, les observations à l’examen physique, les critères diagnostiques et les options de prise en charge du conflit fémoroacétabulaire (CFA). Sources des données Une recherche documentaire a été effectuée dans PubMed pour trouver des articles pertinents sur la pathogenèse, le diagnostic, le traitement et le pronostic du CFA. Message principal Depuis les dernières années, on reconnaît de plus en plus que le CFA est un précurseur potentiel et une étiologie importante des douleurs à la hanche dans la population adulte et de la coxarthrose idiopathique plus tard dans la vie. Le conflit fémoro-acétabulaire désigne un ensemble d’anomalies morphologiques osseuses de l’articulation de la hanche qui se traduit par un contact anormal durant le mouvement. Le CFA par effet came concerne une proéminence osseuse non sphérique du col fémoral proximal ou de la jonction tête-col. Le CFM par effet tenaille désigne une couverture acétabulaire excessive par-dessus la tête du fémur, qui peut se produire en raison de diverses variantes morphologiques. Les patients qui ont un CFA présentent une douleur inguinale antérieure chronique, profonde ou lancinante, le plus souvent en position assise, durant ou après une activité. Les patients peuvent aussi ressentir des douleurs occasionnelles aiguës durant l’activité. Il faut procéder à une anamnèse approfondie portant notamment sur l’incidence de traumatismes ou la fréquence de l’exercice. Il faut aussi faire un examen physique complet des hanches, de la région lombaire et de l’abdomen pour évaluer d’autres causes de douleurs inguinales antérieures. Le diagnostic de CFA est confirmé par radiographie. Le conflit fémoro-acétabulaire peut être pris en charge selon une approche conservatrice comportant du repos, la modification des activités, des médicaments et de la physiothérapie ou encore être traité par intervention chirurgicale. Conclusion

  3. Professor Aristides Leão. Much more than spreading depression.

    PubMed

    Maranhão-Filho, Péricles; Vincent, Maurice

    2009-01-01

    Professor Leão described cortical spreading depression (CSD) in 1944 and changed the way migraine pathophysiology is scientifically conceived. This Brazilian professor and researcher developed his career in Rio de Janeiro. Because of him, the city once became the CSD world capital, attracting scientists from many laboratories around the globe. Aristides Leão was first and foremost a naturalist, a man genuinely interested in birds, fishes, plants, shells, and neuroscience. He could easily fascinate whoever would come for a chat, leaving no question without answers. He was born in 1914 and died in 1993. This report focuses on his life, family, habits, and hobbies, describing a little of Leão apart from CSD and the year of 1944. PMID:18647182

  4. Oxygen Isotopic Analyses of Water in Bjurböle Matrix and Chondrules

    NASA Astrophysics Data System (ADS)

    Nunn, M.; Thiemens, M. H.

    2011-12-01

    Past oxygen isotopic analyses of the Bjurböle meteorite have been limited to whole rock and chondrule studies. We present here the first oxygen isotopic measurements of water contained in the matrix and chondrules of the L4 equilibrated ordinary chondrite Bjurböle. Water was extracted by vacuum pyrolysis from samples of separated matrix and chondrules from Bjurböle. A new, low volume, ultra low blank system was built specifically for these measurements. Each fraction was pumped overnight on a vacuum line to remove as much adsorbed terrestrial water as possible before heating step-wise to 150, 350, 600 and 1000°C. While heating, evaporated volatiles were collected in a liquid nitrogen cold trap. Water was quantitatively converted to molecular oxygen with bromine pentafluoride. Isotopic abundances were measured on a double-collecting isotope ratio mass spectrometer. The Δ 17O values obtained from direct fluorination of Bjurböle chondrules and whole rock and UV laser probe analyses of individual Bjurböle chondrules all cluster around one [1, 2]. Compared to these data, water extracted from the Bjurböle matrix and chondrules is isotopically light (Δ 17O = 0.5 and 0.7, respectively), presumably reflecting different equilibration histories of water and oxygen-bearing minerals in each component. Additionally, the proximity of Δ 17O values of water extracted at lower temperatures to zero indicates low-temperature heating is necessary to remove all adsorbed terrestrial water and obtain the true isotopic signature of extraterrestrial water.

  5. Infection par le virus de l’hépatite E durant la grossesse

    PubMed Central

    Chaudhry, Shahnaz A.; Verma, Natasha; Koren, Gideon

    2015-01-01

    Résumé Question Plusieurs de mes patientes sont originaires de l’Asie du Sud-Est où le virus de l’hépatite E est assez commun. Quelles précautions puis-je leur suggérer de prendre avant de voyager dans cette région et quels sont les risques d’une infection par le VHE durant la grossesse? Réponse L’hépatite E est un pathogène présent dans l’eau qui se transmet par voie oro-fécale. Afin de réduire le risque de contracter le VHE lors de voyages dans des régions endémiques, il est important de maintenir des pratiques d’hygiène telles que se laver les mains avec de l’eau potable, particulièrement avant de manipuler de la nourriture, éviter de boire de l’eau ou d’utiliser des glaçons de pureté inconnue et ne pas manger de fruits ou de légumes non pelés. Actuellement, il n’existe aucun vaccin disponible au Canada pour le VHE. Une infection à l’hépatite E durant la grossesse, surtout durant le troisième trimestre, se caractérise par une infection plus sévère qui se transforme parfois en hépatite fulminante, augmentant ainsi les risques de mortalité et de morbidité maternelles et fœtales.

  6. Oncoplastie avec conservation mammaire dans le traitement du cancer du sein: à propos de 16 cas

    PubMed Central

    Bouzoubaa, Wail; Laadioui, Meryam; Jayi, Sofia; Alaoui, Fatime Zahra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2015-01-01

    Le cancer du sein est actuellement le cancer le plus fréquent chez la femme, et pose un véritable problème diagnostique et thérapeutique. Le dépistage des lésions à un stade de plus en plus précoce, a permis une extension des indications du traitement conservateur radiochirurgical, qui était initialement limitées aux tumeurs de moins de 3 cm, unifocales, non inflammatoires. Par ailleurs, l'utilisation de traitements préopératoires permet d’étendre les indications du traitement conservateur à des tumeurs plus volumineuses. Parallèlement à cette extension des indications de conservation mammaire, on a observé le développement de nouvelles approches thérapeutiques notamment la chirurgie oncoplastique, technique du ganglion sentinelle et chirurgie stéréotaxique, dont les résultats initiaux sont très encouragent. A travers cette étude réalisée dans le service de gynécologie et obstétrique II du CHU HASSAN II de FES au MAROC, après l'analyse rétrospective de 16 patientes traitées par traitement conservateur et oncoplastie, nous avons voulus montrer notre aptitude a réalisé ses techniques chirurgicales et a bien prendre en charge ces patientes, mais aussi évaluer ces techniques en termes de résultat carcinologique et de résultat esthétique, aussi en terme de survie globale, survie sans métastase et en termes de récidive locale entre les plasties mammaires et les traitements usuels: mastectomie et traitement conservateur classique. PMID:26430477

  7. le de la radiothérapie dans le traitement de l'améloblastome: à propos de deux cas

    PubMed Central

    El Mazghi, Abderrahman; Bouhafa, Touria; El Kacemi, Hanan; Loukili, Kaoutar; Chbani, Laila; Kebdani, Taieb; Hassouni, Khalid

    2014-01-01

    L'améloblastome est une tumeur odontogène bénigne mais à pouvoir agressif et invasif local important. C'est une tumeur rare, elle représente 1% des tumeurs des maxillaires. Lele de la radiothérapie dans son traitement est actuellement démontré pour les tumeurs inopérables. Nous rapportons 2 cas d'améloblastomes mandibulaires chez deux patients qui ont bénéficié d'une radiothérapie externe à la dose de 60 Gy. L’évolution a été marquée par une rémission complète de la maladie dans les deux cas avec un recul de 2 et 5 ans. PMID:25722762

  8. Testing QCD at high energy e{sup +}e{sup {minus}} colliders: 0.5 {le} Q {le} 2 TeV

    SciTech Connect

    Burrows, P.N.

    1996-01-01

    A review is presented of the possibilities for making precise tests of Quantum Chromodynamics at high energy e{sup +}e{sup {minus}} colliders operating at center-of-mass energies in the range 0.5 {le} Q {le} 2 TeV. Throughout, the acronym HLC, representing High energy Linear e{sup +}e{sup {minus}} Collider, will be used to denote the set of colliders comprising NLC, JLC, CLIC, TESLA and VLEPP that have been proposed by the respective geo-political consortia to confront the supra-national physics. It is assumed that the collider will be designed to deliver an integrated luminosity of 50 fb{sup {minus}1} per year of running at 500 GeV, and 100 fb{sup {minus}1} per year of running at 1 TeV.

  9. Conductivite dans le modele de Hubbard bi-dimensionnel a faible couplage

    NASA Astrophysics Data System (ADS)

    Bergeron, Dominic

    Le modele de Hubbard bi-dimensionnel (2D) est souvent considere comme le modele minimal pour les supraconducteurs a haute temperature critique a base d'oxyde de cuivre (SCHT). Sur un reseau carre, ce modele possede les phases qui sont communes a tous les SCHT, la phase antiferromagnetique, la phase supraconductrice et la phase dite du pseudogap. Il n'a pas de solution exacte, toutefois, plusieurs methodes approximatives permettent d'etudier ses proprietes de facon numerique. Les proprietes optiques et de transport sont bien connues dans les SCHT et sont donc de bonne candidates pour valider un modele theorique et aider a comprendre mieux la physique de ces materiaux. La presente these porte sur le calcul de ces proprietes pour le modele de Hubbard 2D a couplage faible ou intermediaire. La methode de calcul utilisee est l'approche auto-coherente a deux particules (ACDP), qui est non-perturbative et inclue l'effet des fluctuations de spin et de charge a toutes les longueurs d'onde. La derivation complete de l'expression de la conductivite dans l'approche ACDP est presentee. Cette expression contient ce qu'on appelle les corrections de vertex, qui tiennent compte des correlations entre quasi-particules. Pour rendre possible le calcul numerique de ces corrections, des algorithmes utilisant, entre autres, des transformees de Fourier rapides et des splines cubiques sont developpes. Les calculs sont faits pour le reseau carre avec sauts aux plus proches voisins autour du point critique antiferromagnetique. Aux dopages plus faibles que le point critique, la conductivite optique presente une bosse dans l'infrarouge moyen a basse temperature, tel qu'observe dans plusieurs SCHT. Dans la resistivite en fonction de la temperature, on trouve un comportement isolant dans le pseudogap lorsque les corrections de vertex sont negligees et metallique lorsqu'elles sont prises en compte. Pres du point critique, la resistivite est lineaire en T a basse temperature et devient

  10. Interpretation des donnees de flux de chaleur et de gravite dans le bouclier Canadien

    NASA Astrophysics Data System (ADS)

    Cheng, Li Zhen

    2000-10-01

    Le champ geothermique du Bouclier Canadien est caracterise par un flux moyen de 41 mW·m-2, qui suggere une production de chaleur moyenne dans la croute comprise entre 0.7 et 0.8 muW·m-3. Le flux de chaleur relativement faible favorise la stabilite du bouclier et lui a permis de resister a la deformation tectonique. Les variations du flux de chaleur a la surface sont dominees par la composition de la croute. Un flux eleve implique generalement une composition felsique et il est d'autant plus faible que la croute devient plus mafique. La production de chaleur en surface n'est pas representative de la production moyenne de la croute. Le flux de chaleur dans le Boucher Canadien ne depend donc pas de la production de chaleur en surface, mais depend de la composition principale de la croute. L'interpretation combinee des donnees geophysiques nous permet de determiner les variations de composition d'echelle crustale a partir desquelles il est possible d'etablir la structure de la croute. L'etude detaillee de l'Orogene de Trans-Hudson et de la Sous-province d'Abitibi a montre que le flux de chaleur, la gravite et la sismique lorsqu'elles sont combinees fournissent des contraintes efficaces pour determiner l'architecture crustale. En general, la croute est trop resistante pour se deformer par fluage, excepte tres localement. Le mode de deformation de la lithosphere continentale depend de la composition et du gradient geothermique. Nous montrons que la lithosphere du Bouclier Canadien demeure principalement fragile jusqu'a une profondeur de plus de 150 km. Une deformation ductile pourrait cependant etre possible localement a la base de la, croute, comme dans la ceinture de Thompson par exemple. Si l'on admet que la lithosphere peut resister a des contraintes allant jusqu'a 20 MPa (taux de deformation 3˙ < 10-15 s-1), l'epaisseur de la lithosphere est de l'ordre de 300 km pour la ceinture de Thompson et est superieure a 300 km pour la sous-province d'Abitibi. La resistance

  11. Le glaucome congénitale et la neurofibromatose type 1

    PubMed Central

    Tzili, Nazih; El Orch, Hamza; Bencherifa, Fatiha; Chefchaouni, Mohammed Charif; Abdallah, El Hassan; Berraho, Amina

    2015-01-01

    Le glaucome congénital constitue une complication ophtalmologique dans la neurofibromatose type 1 ou maladie de von Recklinghausen. Nous rapportons un cas de glaucome congénitale dans le cadre d'une neurofibromatose de type 1, à travers lequel on va discuter les mécanismes étiopathogénique, les difficultés thérapeutiques et les facteurs pronostiques du glaucome congénital au cours la maladie de von Recklinghausen avec revue de la littérature. PMID:26405492

  12. Systèmes d'imagerie à haute résolution dans le domaine des Rayons X pour le Laser Mégajoule

    NASA Astrophysics Data System (ADS)

    Champeaux, J.-Ph.; Troussel, Ph.; Boutin, J.-Y.; Lidove, G.; Marmoret, R.; Soullié, G.; Rosch, R.

    2006-12-01

    Le principe de la fusion par confinement inertiel consiste à faire imploser une cible sphérique de petite taille, millimétrique, remplie d'un mélange de deutérium et de tritium sous l'action des 240 faisceaux lasers impulsionnels de très grande puissance du LMJ. Les études de cette physique d'implosion (mise en vitesse, symétrie d'implosion, instabilités hydrodynamiques) et de l'allumage (traceurs, point chaud) font appel aux techniques de l'imagerie et de la radiographie à haute résolution spatiale (μm) et temporelle (ps) avec sélection spectrale dans le domaine d'énergie de photons comprise entre 100 eV et 20 keV. Plusieurs Systèmes d'Imagerie X (SIX), à haute résolution spatiale, ont donc été développés par le CEA-DIF et mis en œuvre sur la Ligne d'Intégration Laser (LIL) implantée au CEA-CESTA. Dans cet article nous présentons les principaux SIX, à base de microscopes à miroirs. Un exemple de microscope prototype nommé PIXEL (Plasma Imageur X pour les Expériences Lasers) développé pour le LMJ est présenté. Nous portons l'accent sur les problèmes technologiques liés à l'environnement LMJ.

  13. The Center for Learning Technologies in Urban Schools (LeTUS) Program[R]. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2012

    2012-01-01

    The "LeTUS" program is a three-year, project-based, technology-integrated middle school science curriculum for grades 6-8. The "LeTUS" program is composed of multiple units, each lasting between eight and ten weeks. Topics include global warming, water and air quality, force and motion, communicable diseases, and ecological systems. The units are…

  14. Le conte: Mille et une facons de dire... (The Story: A Thousand and One Ways to Say...).

    ERIC Educational Resources Information Center

    Cazaux, Henri

    1996-01-01

    A teacher/storyteller recommends story creation by students to encourage creativity and pleasure in developing language skills. Suggested exercises include combining random nouns (e.g., "le fer et le bois") and creating a proverb about them, creating a story using names of consumer products, and developing a story using only body-language idioms…

  15. LeCPK1, a Calcium-Dependent Protein Kinase from Tomato. Plasma Membrane Targeting and Biochemical Characterization1

    PubMed Central

    Rutschmann, Frank; Stalder, Urs; Piotrowski, Markus; Oecking, Claudia; Schaller, Andreas

    2002-01-01

    The cDNA of LeCPK1, a calcium-dependent protein kinase, was cloned from tomato (Lycopersicon esculentum Mill.). LeCPK1 was expressed in Escherichia coli and purified from bacterial extracts. The recombinant protein was shown to be a functional protein kinase using a synthetic peptide as the substrate (syntide-2, Km = 85 μm). Autophosphorylation of LeCPK1 was observed on threonine and serine residues, one of which was identified as serine-439. Kinase activity was shown to be Ca2+ dependent and required the C-terminal, calmodulin-like domain of LeCPK1. Two classes of high- and low-affinity Ca2+-binding sites were observed, exhibiting dissociation constants of 0.6 and 55 μm, respectively. LeCPK1 was found to phosphorylate the regulatory C-terminal domain of the plasma membrane H+-ATPase in vitro. A potential role in the regulation of proton pump activity is corroborated by the apparent colocalization of the plasma membrane H+-ATPase and LeCPK1 in vivo. Upon transient expression in suspension-cultured cells, a C-terminal fusion of LeCPK1 with the green fluorescent protein was targeted to the plasma membrane. Myristoylation of the LeCPK1 N terminus was found to be required for plasma membrane targeting. PMID:12011347

  16. Cutaneous leishmaniasis due to Leishmania chagasi/Le. infantum in an endemic area of Guarico State, Venezuela.

    PubMed

    De Lima, H; Rodríguez, N; Feliciangeli, M D; Barrios, M A; Sosa, A; Agrela, I; Sánchez, E; Lopez, O

    2009-07-01

    This study reports cutaneous leishmaniasis (CL) caused by Leishmania chagasi/Le. infantum in Venezuela, with some atypical characteristics. Out of 63 cases of CL in the suburbs of Altagracia de Orituco, Guarico State, Venezuela, 30 presented clinical, parasitological, immunological and epidemiological features different from those of the classical CL known in the country. The initial lesion was small and nodular, which, if not treated, might progress to a superficial ulcer. No secondary infection was observed. The identification of the isolates was carried out by molecular techniques. Twelve species of phlebotomine sandflies were caught, the most abundant being Lutzomyia evansi and Lu. longipalpis s.l., known vectors of Le. chagasi/Le. infantum. The existence of Le. chagasi/Le. infantum and its vectors in an endemic area of CL has implications and we suggest that epidemiological studies should be carried out to obtain a clearer picture of the extent of this CL form in Venezuela. PMID:19150102

  17. Tested Demonstrations: Thermodynamic Changes, Kinetics, Equilibrium, and LeChatelier's Principle.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1984-01-01

    Procedures for demonstrating thermodynamic changes, kinetics and reaction mechanisms, equilibrium, and LeChatelier's principle are presented. The only materials needed for these demonstrations are beakers, water, assorted wooden blocks of varying thickness, assorted rubber tubing, and a sponge. The concepts illustrated in each demonstration are…

  18. The Potassium-Argon Laser Experiment (KarLE): In Situ Geochronology for Mars and Beyond

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara A.

    2014-01-01

    The search for life in the solar system depends upon discovering the right moments in planetary evolution: when habitable environments existed, when they declined, and when geologic processes operated to preserve traces of life after death. However, an incomplete knowledge of absolute Martian geochronology limits our ability to understand the timing of Martian evolutionary milestones, major climate changes, and stratigraphic epochs [1, 2]. Absolute dating relates these habitability markers to planetarywide geologic, atmospheric, and climate history places, and ties their occurrence to the history of the solar system, especially the Earth-Moon system and the timescale of evolution of life on Earth. KArLE is being developed to anchor the relative timeline of geological events to an absolute chronology that puts Mars into a wider solar system context. KArLE makes its measurements on rock samples that can be obtained by landers or rovers and inserted into a small, mechanically simple chamber. KArLE interrogates the samples using laser-induced breakdown spectrocopy (LIBS), mass spectrometry, and optical imaging. The KArLE experiment is flexible enough to accommodate any partner providing these instrument components, a creative approach that extends the ability of mission payloads to accomplish an additional highly-desirable science measurement for low cost and risk and minimal extra hardware.

  19. Geomorphic evolution of the Le Sueur River, Minnesota, USA, and implications for current sediment loading

    USGS Publications Warehouse

    Gran, K.B.; Belmont, P.; Day, S.S.; Jennings, C.; Johnson, Aaron H.; Perg, L.; Wilcock, P.R.

    2009-01-01

    There is clear evidence that the Minnesota River is the major sediment source for Lake Pepin and that the Le Sueur River is a major source to the Minnesota River. Turbidity levels are high enough to require management actions. We take advantage of the well-constrained Holocene history of the Le Sueur basin and use a combination of remote sensing, fi eld, and stream gauge observations to constrain the contributions of different sediment sources to the Le Sueur River. Understanding the type, location, and magnitude of sediment sources is essential for unraveling the Holocene development of the basin as well as for guiding management decisions about investments to reduce sediment loads. Rapid base-level fall at the outlet of the Le Sueur River 11,500 yr B.P. triggered up to 70 m of channel incision at the mouth. Slope-area analyses of river longitudinal profi les show that knickpoints have migrated 30-35 km upstream on all three major branches of the river, eroding 1.2-2.6 ?? 109 Mg of sediment from the lower valleys in the process. The knick zones separate the basin into an upper watershed, receiving sediment primarily from uplands and streambanks, and a lower, incised zone, which receives additional sediment from high bluffs and ravines. Stream gauges installed above and below knick zones show dramatic increases in sediment loading above that expected from increases in drainage area, indicating substantial inputs from bluffs and ravines.

  20. 5. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 INTERIOR DETAIL, NORTHEAST AND SOUTHEAST PARLORS, ORIGINAL MANTEL (LEFT - RADIATOR COVERED). - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  1. The Adverse Effects of Le Chatelier's Principle on Teacher Understanding of Chemical Equilibrium

    ERIC Educational Resources Information Center

    Cheung, Derek

    2009-01-01

    Although the scientific inadequacy of Le Chatelier's principle has long been documented in the literature, the principle is still treated as a central concept of chemical equilibrium by textbook writers and teachers in many countries. In the past, researchers' interest has focused on student misconceptions about chemical equilibrium and has…

  2. Students' and Teachers' Misapplication of Le Chatelier's Principle: Implications for the Teaching of Chemical Equilibrium.

    ERIC Educational Resources Information Center

    Quilez-Pardo, Juan; Solaz-Portoles, Joan Josep

    1995-01-01

    Study of strategies and procedures of 170 students and 40 teachers when solving chemical equilibrium problems found misconceptions emerging through: misapplication of Le Chatelier's Principle, use of rote-learning recall, incorrect control of variables, limited use of chemical equilibrium law, lack of mastery of chemical equilibrium principles,…

  3. LE[superscript 3]AD Academy Builds Professionalism in Vocational Students

    ERIC Educational Resources Information Center

    Hall, Candace

    2012-01-01

    Principal David Wheeler of Southeastern Regional Vocational-Technical High School founded LE[superscript 3]AD Academy--an innovative program that gives students the opportunity to build and run their own town in teams and with guidance from teachers. The program started in the spring of 2011, and it is innovative in many ways. The students' main…

  4. Reflections on "Petit Battement sur le Cou de Pied": Is It Still Relevant?

    ERIC Educational Resources Information Center

    Paskevska, Anna

    2007-01-01

    This article presents multiple perspectives of "petit battement sur le cou de pied". These perspectives include historical, biomechanical, and pedagogic points of view. The article offers useful information for ballet specialists and applied research studies aimed at ballet pedagogy. (Contains 2 tables and 5 figures.)

  5. Developing Communication Skills in Deaf Primary School Pupils: Introducing and Evaluating the SmiLE Approach

    ERIC Educational Resources Information Center

    Alton, Sherryn; Herman, Rosalind; Pring, Tim

    2011-01-01

    Many profoundly deaf signers have difficulty communicating with hearing people. This article describes a therapy called "Strategies and Measurable Interaction in Live English" (smiLE; Schamroth and Threadgill, 2007a), an approach used to teach deaf children skills to become successful communicators in real-life situations. This study evaluates the…

  6. Coût clinique des retards dans le changement de traitement

    PubMed Central

    Walmsley, Sharon

    2007-01-01

    La prise en charge des patients séropositifs pour le VIH ayant déjà reçu un traitement continue de s’améliorer et d’évoluer. Les nouvelles lignes directrices semblent indiquer que l’objectif du traitement devrait être une suppression virologique maximale. La meilleure façon d’y parvenir consiste à utiliser une combinaison d’agents auxquels le virus sera le plus vraisemblablement sensible et, si possible, des agents appartenant à une nouvelle classe thérapeutique. Les cas discutés démontrent comment l’utilisation d’un schéma thérapeutique puissant à titre de traitement de sauvetage peut avoir de bons résultats virologiques, immunologiques et cliniques. Toutefois, si le traitement de sauvetage retenu n’est pas assez puissant pour atteindre ces objectifs, la durabilité de la réponse est limitée. Ce qu’il faut retenir ici, c’est que ces stratégies devraient reposer sur la puissance du schéma thérapeutique et qu’il ne faut pas retarder l’instauration des agents en cas d’échec d’une stratégie.

  7. The Ammonia Synthesis Reaction: An Exception to the Le Chatelier Principle and Effects of Nonideality

    ERIC Educational Resources Information Center

    Uline, Mark J.; Corti, David S.

    2006-01-01

    Le Chatelier's principle states that the further addition of a particular component will cause the reaction to shift in the direction that reduces the total number of moles of the system. However, the addition of one reactant [N[subscript 2

  8. Molecular and cellular characterization of the tomato pollen profilin, LePro1

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Profilin is an actin-binding protein involved in the dynamic turnover and restructuring of the actin cytoskeleton in all eukaryotic cells. We previously cloned a profilin gene, designated as LePro1 from tomato pollen. To investigate its biological role, in the present study, We investigated the tem...

  9. Le syndrome de Stewart-Treves compliquant un lymphœdème chronique idiopathique

    PubMed Central

    Safini, Fatima; Naim, Asmaa; Bouchbika, Zineb; Benchakroun, Nadia; Jouhadi, Hassan; Tawfiq, Nezha; Sahraoui, Souha; Benider, Abdellatif

    2014-01-01

    Le syndrome de Stewart-Treves (SST) est une entité rare, correspondant à un angiosarcome cutané compliquant un lymphoedème chronique. Il est de mauvais pronostic. Stewart et Treves ont rapportés en 1948, les premiers cas d'angiosarcome secondaire à un traitement du cancer du sein. Ce terme s'est généralisé pour regrouper l'ensemble des cas de lymphangiosarcome sur lymphoedème d'origine congénital héréditaire ou non héréditaire, post-traumatique ou post-infectieux. Le SST sur un lymphoedème idiopathique reste exceptionnel. Nous rapportons le cas rare d'une patiente présentant un lymphoedème chronique primitif idiopathique des quatre membres évoluant depuis l'adolescence et qui a développé un SST du membre supérieur droit. Elle a subi une amputation à mi- bras vu le caractère très évolué de la tumeur PMID:25883738

  10. 10. VIEW TOWARD PORT BOW IN THE FOC'S'LE OF THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. VIEW TOWARD PORT BOW IN THE FOC'S'LE OF THE EVELINA M. GOULART. OBJECT IN THE FOREGROUND IS A FOLDING MESS TABLE LOCATED BETWEEN THE TIERS OF BUNKS. - Auxiliary Fishing Schooner "Evelina M. Goulart", Essex Shipbuilding Museum, 66 Main Street, Essex, Essex County, MA

  11. Through Ecofeminist Eyes: Le Guin's "The Ones Who Walk Away from Omelas"

    ERIC Educational Resources Information Center

    Bennett, Barbara

    2005-01-01

    Barbara Bennett explains the tenets behind ecofeminism and why it is a useful and appropriate method of literary analysis for today's world. By applying the theory to Le Guin's story, she helps her students relate the issues of ecofeminism to their American lifestyle.

  12. Habitat and nesting of Le Conte's Sparrows in the northern tallgrass prairie

    USGS Publications Warehouse

    Winter, M.; Shaffer, J.A.; Johnson, D.H.; Donovan, T.M.; Svedarsky, W.D.; Jones, P.W.; Euliss, B.R.

    2005-01-01

    Little is known about the breeding biology of the Le Conte's Sparrow (Ammodramus leconteii), probably because of its secretive nature. We provide new information on several aspects of Le Conte's Sparrow breeding biology, including rates of nest parasitism by Brown-headed Cowbirds (Molothrus ater) and potential factors affecting breeding densities and nesting success of the species. Our study was conducted in the tallgrass prairie of northwestern Minnesota and southeastern North Dakota during 1998-2002. Breeding densities varied among years, but this variation was not clearly linked to climatic patterns. Vegetation had some influence on densities of Le Conte's Sparrows; densities were highest in grasslands with moderate amounts of bare ground. Prairie patch size and the percentage of shrubs and trees in the landscape had no recognizable influence on density. Nesting success was highly variable among sites and years and increased slightly with distance from trees. Rates of nest parasitism were low (1 of 50 nests parasitized), and clutch sizes were similar to those of other studies of Le Conte's Sparrows.

  13. Le monde des affaires (The Business World). Teacher's Guide [and] Student's Book.

    ERIC Educational Resources Information Center

    Laing, Martha; Ullmann, Rebecca

    The two components of this publication are the student's book and the teacher's guide to the module, "The Business World" or "Le monde des affaires," which would be suitable for use in an advanced French course or in a class of business French. The teacher's book in French and English has four parts: (1) an explanation of the meaning and use of…

  14. La prévention de l’infection par le virus respiratoire syncytial

    PubMed Central

    Samson, L

    2009-01-01

    L’infection par le virus respiratoire syncytial (VRS) est la principale cause d’infection des voies respiratoires inférieures chez les jeunes enfants et pour cette raison, bon nombre des prématurés et des enfants présentant d’autres facteurs de risque doivent être hospitalisés chaque année au Canada. Le palivizumab, un anticorps monoclonal anti-VRS, peut réduire le taux d’hospitalisation et la gravité de la maladie d’un petit groupe de prématurés ou de nourrissons à haut risque pendant leur première saison de VRS. Le présent document de principes contient une analyse des publications ainsi que des recommandations à l’intention des médecins canadiens au sujet de son utilisation chez les prématurés et les autres nourrissons à risque.

  15. Evaluation of LeVeen-shunt patency using Tc-99m labelled macroaggregated albumin.

    PubMed

    Adil, Allah Rakha; Waqar, Amin

    2005-12-01

    A LeVeen peritoneo-venous shunt is placed for intractable ascites. Determination of obstruction site in the shunt tube is a difficult problem. We describe a simple nuclear medicine method using 111MBq (3mCi) of Technetium-99m labeled macro-aggregated albumin injected intraperitoneally. PMID:16398982

  16. Developement of the Potassium-Argon Laser Experiment (KArLE) for In Situ Geochronology

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara A.

    2012-01-01

    Absolute dating of planetary samples is an essential tool to establish the chronology of geological events, including crystallization history, magmatic evolution, and alteration. Thus far, radiometric geochronology of planetary samples has only been accomplishable in terrestrial laboratories on samples from dedicated sample return missions and meteorites. In situ instruments to measure rock ages have been proposed, but none have yet reached TRL 6, because isotopic measurements with sufficient resolution are challenging. We have begun work under the NASA Planetary Instrument Definition and Development Program (PIDDP) to develop the Potassium (K) - Argon Laser Experiment (KArLE), a novel combination of several flight-proven components that will enable accurate KAr isochron dating of planetary rocks. KArLE will ablate a rock sample, measure the K in the plasma state using laser-induced breakdown spectroscopy (LIBS), measure the liberated Ar using quadrupole mass spectrometry (QMS), and relate the two by measuring the volume of the abated pit using a optical methods such as a vertical scanning interferometer (VSI). Our preliminary work indicates that the KArLE instrument will be capable of determining the age of several kinds of planetary samples to 100 Myr, sufficient to address a wide range of geochronology problems in planetary science. Additional benefits derive from the fact that each KArLE component achieves analyses common to most planetary surface missions.

  17. "Ambivalence to Technology in Jeunet's" Le Fabuleux Destin d'Amelie Poulain

    ERIC Educational Resources Information Center

    Moore, Rick Clifton

    2006-01-01

    Although at one level Jean-Pierre Jeunets "Le Fabuleux Destin d'Amelie Poulain" is a sweet, attractive film about a young Parisian doing good deeds, it also offers a compelling analysis of the role of technology in our modern lives. The film paints a world where machines and a mechanistic worldview are appealing because humans have a desire to…

  18. List processing software for the LeCroy 1821 Segment Manager Interface

    SciTech Connect

    Dorries, T.; Moore, C.; Pordes, R.

    1987-05-01

    Many experiments at Fermilab now include some FASTBUS electronics in their data readout. The software reported in this paper provides general support for the LeCroy 1821 interface. The list processing device drivers allow FASTBUS data to be read out efficiently into the Fermilab Computing Department supported data acquisition systems.

  19. Literature and the Teaching of Culture: The Example of Roger Ikor's "Le Tourniquet des innocents."

    ERIC Educational Resources Information Center

    Hodgson, Richard G.

    1983-01-01

    Roger Ikor's 1972 novel "Le Tourniquet des innocents" is proposed for advanced university-level French culture courses, illustrating how the study of a contemporary novel can be integrated into cultural education. Classroom activities suggested include text analyses, study of cultural themes, and preparation of a lexicon featuring cultural…

  20. Tuning LeSPL-CNR expression by SlymiR157 affects tomato fruit ripening

    PubMed Central

    Chen, Weiwei; Kong, Junhua; Lai, Tongfei; Manning, Kenneth; Wu, Chaoqun; Wang, Ying; Qin, Cheng; Li, Bin; Yu, Zhiming; Zhang, Xian; He, Meiling; Zhang, Pengcheng; Gu, Mei; Yang, Xin; Mahammed, Atef; Li, Chunyang; Osman, Toba; Shi, Nongnong; Wang, Huizhong; Jackson, Stephen; Liu, Yule; Gallusci, Philippe; Hong, Yiguo

    2015-01-01

    In plants, microRNAs (miRNAs) play essential roles in growth, development, yield, stress response and interactions with pathogens. However no miRNA has been experimentally documented to be functionally involved in fruit ripening although many miRNAs have been profiled in fruits. Here we show that SlymiR157 and SlymiR156 differentially modulate ripening and softening in tomato (Solanum lycopersicum). SlymiR157 is expressed and developmentally regulated in normal tomato fruits and in those of the Colourless non-ripening (Cnr) epimutant. It regulates expression of the key ripening gene LeSPL-CNR in a likely dose-dependent manner through miRNA-induced mRNA degradation and translation repression. Viral delivery of either pre-SlymiR157 or mature SlymiR157 results in delayed ripening. Furthermore, qRT-PCR profiling of key ripening regulatory genes indicates that the SlymiR157-target LeSPL-CNR may affect expression of LeMADS-RIN, LeHB1, SlAP2a and SlTAGL1. However SlymiR156 does not affect the onset of ripening, but it impacts fruit softening after the red ripe stage. Our findings reveal that working together with a ripening network of transcription factors, SlymiR157 and SlymiR156 form a critical additional layer of regulatory control over the fruit ripening process in tomato. PMID:25597857

  1. From Interactive Open Learner Modelling to Intelligent Mentoring: STyLE-OLM and Beyond

    ERIC Educational Resources Information Center

    Dimitrova, Vania; Brna, Paul

    2016-01-01

    STyLE-OLM (Dimitrova 2003 "International Journal of Artificial Intelligence in Education," 13, 35-78) presented a framework for interactive open learner modelling which entails the development of the means by which learners can "inspect," "discuss" and "alter" the learner model that has been jointly…

  2. Spectrofluorimetric determination of dopamine receptor antagonist LE 300 in mice plasma.

    PubMed

    Hefnawy, Mohamed; Mohamed, Mostafa; Abunassif, Mohamed; Alanazi, Amer; Al-Majed, Abdulrahman; Jochen, Lehmann; Mostafa, Gamal Abdel-Hafiz

    2016-02-01

    A simple, rapid and highly sensitive spectrofluorimetric method was developed for determination of a novel type of dopamine receptor antagonist LE300 in mouse plasma. The method is based on measuring the native fluorescence of LE-300 in methanol at 343 nm after excitation at 280 nm. The fluorescence concentration plot was rectilinear over the range of 3.5-100 ng/mL with a lower detection limit of 1.0 ng/mL and quantification limit of 3.5 ng/mL. The method was statistically validated for linearity, accuracy, precision and selectivity according to the International Conference on Harmonization guidelines. The accuracy and precision results was expressed as % recovery and relative standard deviation (RSD). The accuracy for LE-300 was in the range 95.5-103.6% and RSD values were in the range of 0.21-1.55% of the theoretical value. The method was successfully applied to the analysis of LE-300 in mice plasma. The results were compared statistically with those obtained by the reported method and were found to be in good agreement, which could be applied in a pharmacokinetic study. PMID:25892547

  3. Le syndrome de cushing chez l'adolescent: à propos de 18 patients

    PubMed Central

    Haraj, Nassim Essabah; El Aziz, Siham; Chadli, Asma

    2015-01-01

    Le syndrome de Cushing est une pathologie rare mais grave chez l'enfant et l'adolescent. Elle diffère de la pathologie adulte par le mode de présentation et la prise en charge. Il s'agit d'une étude rétrospective des dossiers de patients suivis pour syndrome de Cushing au service d'endocrinologie de Casablanca entre 2002 - 2015, incluant les patients âgés au moment du diagnostic de moins de 22 ans, et ayant un suivi d'au moins 1 an. Au total 18 dossiers ont été inclus. L’âge moyen est de 19,55 ans, avec une prédominance féminine. La durée d’évolution moyenne est de 4,05 ans. Le tableau clinique est fait souvent d'une cassure de poids, une obésité ou une séborrhée et acné. La démarche diagnostique est comparable à celle de l'adulte. Sur le plan étiologique on retrouve une prédominance de la maladie de Cushing (15 patients). Sur le plan thérapeutique, 14 patients ont bénéficié d'une chirurgie hypophysaire, avec complément par radiothérapie chez 3 patients devant l’échec de la chirurgie, Une ablation d'une tumeur surrénalienne chez une patiente et une surrénalectomie bilatérale chez trois patients. L’évolution a été marquée par une guérison chez 9 patients et le décès chez 4 (suite à un syndrome de Nelson, infection sévère, choc hémorragique, corticosurrénalome). Les résultats de cette étude soulignent la gravité de cette maladie, ce qui nécessite d'organiser le suivi, en élaborant des programmes spécifiques de suivi médical et de prise en charge psychologique. PMID:26985265

  4. Le dermatofibrosarcome de Darier et Ferrand: à propos de 27 cas et revue de la literature

    PubMed Central

    Hammas, Nawal; Badioui, Ikram; Znati, Kaoutar; Benlemlih, Amal; Chbani, Laila; El Fatemi, Hind; Harmouch, Taoufiq; Bouyahyaoui, Youssef; Boutayeb, Faouzi; Mrini, Abdelmajid; Mesbahi, Omar; Mernissi, Fatima Zahra; Amarti, Afaf

    2014-01-01

    Le dermatofibrosarcome de Darier et Ferrand (DFS) est une tumeur mésenchymateuse cutanée de malignité intermédiaire. C'est une tumeur rare mais non exceptionnelle, représentant 0,1% des tumeurs cutanées malignes. Les auteurs présentent une étude rétrospective de 27 cas de DFS diagnostiqués sur une durée de 7 ans (2004 à 2010) et la comparent aux données de la littérature. Cette étude permet d’établir en plus des caractéristiques anatomopathologiques et immunohistochimiques, une étude épidémiologique, clinique et évolutive de ce sarcome. l’âge moyen de nos patients est de 41 ans avec une prédominance masculine. Le tronc est la localisation préférentielle touché dans 52% des cas. La taille tumorale a atteint 30cm et mesure en moyenne 6,1 cm. Le diagnostic était évoqué à l'examen histologique standard et confirmé par l'expression intense et diffuse du CD34. Le traitement était chirurgical, associé à une radiothérapie dans 2 cas. L’évolution était marquée par la transformation en un sarcome pléomorphe de haut grade dans un cas et par la survenue de récidives locales dans 2 cas. Nos résultats sont classiques et comparables aux autres séries de la littérature. L'examen histologique est indispensable pour le diagnostic. L'exérèse chirurgicale large est le traitement de référence. Le pronostic est conditionné par une malignité surtout locale et un fort potentiel de récidive. La transformation sarcomateuse franchement maligne métastasiante est exceptionnelle. PMID:25489374

  5. Le cavernome porte chez l'enfant: a propos de 11 cas

    PubMed Central

    Ilham, Tadmori; Mounia, Lakhdar Idrissi; Moustapha, Hida

    2014-01-01

    Le cavernome portal est la conséquence d'une occlusion chronique, du système porte extra-hépatique formé d'un réseau de veines dont le calibre est augmenté et au sein desquelles chemine un sang portal hépatopéte. Chez l'enfant, est une cause majeure d'hypertension portale dite «pré ou infra-hépatique» ou encore «extra-hépatique». Onze cas de cavernome porte parmi 78 cas d'hypertension portale ont été colligés au service sur une période allant du Janvier 2003 au Septembre 2012. L’âge de nos patients variait entre 2 et 15 ans et le sexe ratio est de 1,75. Tous nos patients étaient admis au stade d'hypertension portale avec la splénomégalie SMG (100% des cas); hémorragies digestives (63%); ascite (36%); la circulation veineuse collatérale CVC et l'hépatomégalie HMG (27%). L'exploration endoscopique a objectivé la présence de varices ‘sophagiennes dans tous les cas avec une gastropathie hypertensive dans 27% et des varices ectopiques chez 36%. Les perturbations biologiques étaient dominées par la pancytopénie. Le bilan de thrombophilie était demandé pour tous les malades mais réalisé mais n'est réalisé que chez trois revenus normaux chez deux et a objectivé une baisse de protéine S chez le troisième. L’échographie abdominale était le moyen de diagnostic positif et l’écho-doppler a confirmé l'HTP chez tous nos patients. Aucun de nos malades n'a pu être opéré pour le moment. La ligature a été réalisée chez 54,5%. Dix patients ont nécessité une transfusion sanguine. L’évolution globale de nos patients est favorable. La durée moyenne d’évolution du cavernome porte chez nos patients est de quatre ans. PMID:25870732

  6. Gravity in the Century of Light: The Gravitation Theory of Georges-Louis Le Sage

    NASA Astrophysics Data System (ADS)

    Evans, James

    2006-05-01

    Each generation of physicists, or natural philosophers, has sought to place universal gravitation in the context of its own worldview. Often this has entailed an effort to reduce gravitation to something more fundamental. But what is deemed fundamental has, of course, changed with time. Each generation attacked the problem of universal gravitation with the tools of its day and brought to bear the concepts of its own standard model. The most successful eighteenth-century attempt to provide a mechanical explanation of gravity was that of Georges-Louis Le Sage (1724-1803) of Geneva. Le Sage postulated a sea of ultramundane corpuscles, streaming in all directions and characterized by minute mass, great velocity, and complete inelasticity. Mostly these corpuscles just pass through gross bodies such as apples or planets, but a few are absorbed, leading to all the phenomena of attraction. In a voluminous correspondence with nearly all the savants of the day, Le Sage constantly reshaped his arguments for his system in order to appeal to metaphysicians, mechanicians and Newtonians of several varieties. Le Sage's theory is an especially interesting one, for several reasons. First, it serves as the prototype of a dynamical explanation of Newtonian gravity. Second, the theory came quite close to accomplishing its aim. Third, the theory had a long life and attracted comment by the leading physical thinkers of several successive generations, including Laplace, Kelvin, Maxwell and Feynman. Le Sage's theory therefore provides an excellent opportunity for the study of the evolution of attitudes toward physical explanation. The effects of national style in science and generational change take on a new clarity.

  7. Prévention de la maladie thromboembolique veineuse chez le brûlé

    PubMed Central

    Siah, S.; El Farouki, A.

    2014-01-01

    Summary Les complications thromboemboliques sont considérées comme rares chez le patient brûlé. Leur incidence varie selon les études réalisées. Les patients brûlés présentent de nombreux facteurs de risque favorisant la survenue de ces complications. Le diagnostic clinique de la thrombose veineuse profonde et de l’embolie pulmonaire reste difficile vu leur évolution infraclinique et la non spécificité des signes cliniques. L’échodoppler veineux et l’angioscanner thoracique constituent les éléments clés dans la stratégie diagnostique de la thrombose veineuse profonde et de l’embolie pulmonaire chez les patients brûlés. Le traitement ne diffère pas de celui administré aux autres patients non brûlés et victimes de la thrombose veineuse profonde et de l’embolie pulmonaire. La prophylaxie controversée entre les auteurs, est un sujet d’actualité. Plusieurs praticiens et organismes recommandent son utilisation de routine chez les patients brûlés à risque. Elle reste le seul moyen capable d’empêcher la survenue de la maladie thromboembolique veineuse capable d’engager le pronostic vital chez ces patients. Nous rapportons 6 observations de patients brûlés ayant développé une maladie thromboembolique veineuse. PMID:26170780

  8. Trends in hailstorm frequency in Castile-León (Spain)

    NASA Astrophysics Data System (ADS)

    Merino, A.; García, C.; López, L.; García-Ortega, E.; Sánchez, J. L.; Marcos, J. L.; Guerrero-Higueras, A. M.

    2012-04-01

    The Community of Castile-León is located in the NW of the Iberian Peninsula. One of the most frequent meteorological risks in the Community during the summer is hailstorms. On average, in the Province of León, there are 42 days with storms, almost half of them being hailstorms. However, the spatial variability of the storms is very elevated. The majority of these episodes are registered in mountainous areas during the summer months and they have a convective origin. In the present study, making use of the data from the AEMET's meteorological stations situated in Castile and León, we analyzed trends in the frequency of the appearance of this type of storm from the year 1940 until the present. One of the principal problems we found is that the quality of databases generated from the years without hail precipitation data available are frequent. This is due, in large part, to the difficulty in detecting this type of meteor in meteorological stations, given their large spatial variability and their ephemeral character. On the other hand, with the objective of performing a meteorological analysis of the results found, we have also studied the trends in days with rain and the absolute maximum temperature. The overall analysis of results found allowed us to affirm a large variability in the different regions related to climatic hail series and trends found in those regions. Acknowledgements The authors would like to thank the Regional Government of Castile-León for its financial support through the project LE220A11-2. This study was supported by the following grants: CEN20091028; GRANIMETRO (CGL2010-15930); MICROMETEO (IPT-310000-2010-22 ).

  9. Élaboration et validation d'un modèle numérique reflétant le comportement mécanique du fémur sous chargement statique de compression

    NASA Astrophysics Data System (ADS)

    Jacquet, E.; Garbuio, P.; Pernin, J. N.

    2002-12-01

    Pour tenter d'améliorer les techniques d'ostéosynthèse, afin de réduire les fractures du fémur, apparaît la nécessité de développer un modèle géométrique et numérique capable de caractériser le comportement mécanique du fémur humain. La présente étude propose des résultats expérimentaux issus de tests de compression sur fémurs frais équipés de jauges d'extensomètre. Le modèle géométrique est introduit dans un code de calculs par éléments finis pour représenter le champ des déformations à la surface de l'os. On montre la cohérence du modèle au plan qualitatif et des améliorations pouvant être apportées à ce modèle sont discutées.

  10. Direct Regulation of Extracellular Chitinase Production by the Transcription Factor LeClp in Lysobacter enzymogenes OH11.

    PubMed

    Xu, Huiyong; Chen, Hongfu; Shen, Yuemao; Du, Liangcheng; Chou, Shan-Ho; Liu, Hongxia; Qian, Guoliang; Liu, Fengquan

    2016-09-01

    Lysobacter enzymogenes is a gram-negative bacterial biological control agent that produces abundant extracellular enzymes capable of degrading the cell walls of fungal pathogens. In strain OH11, an isolate from China, the global regulator LeClp controls the production of extracellular chitinase by regulating the transcription of the chitinase-encoding gene chiA. Using a combination of bioinformatic, genetic, and biochemical methods, we show that LeClp regulates chiA transcription by directly binding to the chiA promoter region. Although LeClp appears to be important in this role, it is not the sole regulator of chiA transcription. Furthermore, the sequence analysis of putative LeClp binding sites indicated that the LeClp homolog could be involved in the regulation of extracellular chitinase production in diverse Lysobacter spp. by a mechanism similar to that in L. enzymogenes. Our findings present new insights into the molecular mechanism of LeClp in controlling extracellular chitinase activity, providing a fundamental road to elucidate how LeClp regulates the production of other extracellular lytic enzymes in L. enzymogenes. PMID:27385597

  11. Potentially hazardous Asteroid 2007 LE: Compositional link to the black chondrite Rose City and Asteroid (6) Hebe

    NASA Astrophysics Data System (ADS)

    Fieber-Beyer, Sherry K.; Gaffey, Michael J.; Bottke, William F.; Hardersen, Paul S.

    2015-04-01

    The research is an integrated effort beginning with telescopic observations and extending through detailed mineralogical characterizations to provide constraints on the albedo, diameter, composition, and meteorite affinity of near-Earth object-potentially hazardous asteroid (NEO-PHA 2007 LE). Results of the analysis indicate a diameter of 0.56 kilometers (km) and an albedo of 0.08. 2007 LE exhibits a 1-μm absorption feature without a discernible Band II feature. Compositional analysis of 2007 LE reveal Fs17 and Fa19 values, which are consistent with the Fa and Fs values for the H-type ordinary chondrites (Fs14.5-18 and Fa16-20) and of Asteroid (6) Hebe (Fs17 and Fa15). Spectroscopically, 2007 LE does not appear like the average H-chondrite spectra, exhibiting a reddened spectrum and subdued absorption feature. Further investigation of the meteorite classes yielded a black chondrite, Rose City, which is both similar in mineralogy and spectrally to PHA 2007 LE. Dynamical analysis could not directly link the fall of the Rose City meteorite to 2007 LE. As it stands, 2007 LE and Rose City have a compositional link, and both could come from the same parent body/possible family, one known source of the H chondrites is (6) Hebe.

  12. La chirurgie coronaire sous circulation extra-corporelle chez le patient diabétique

    PubMed Central

    Moutakiallah, Younes; Benzaghmout, Khadija; Aithoussa, Mahdi; Atmani, Nourreddine; Amahzoune, Brahim; Hatim, Abdedaim; Drissi, Mohamed; Benyass, Aatif; ElBekkali, Youssef; Boulahya, Abdelatif

    2014-01-01

    Nous rapportons les résultats de la chirurgie coronaire chez une population de coronariens diabétiques opérés sous circulation extra-corporelle dans le service de chirurgie cardiaque de l'hôpital militaire d'instruction Mohammed V de Rabat. C'est une étude rétrospective menée entre Janvier 2008 et Février 2012 (4 ans), portant sur 103 patients diabétiques consécutifs opérés pour pontage coronaire. L’âge moyen des patients était de 61±8,7ans (37-82ans) avec un sexe ratio (H/F) de 3,9. Tous les patients diabétiques de type 2 et sous traitement anti-diabétique ont été inclus dans cette étude. La sténose du tronc commun gauche était présente chez 26,2% des patients et 53,4% étaient tritronculaires. Quatre-vingt patients (78,6%) étaient insulino-nécessitant, l'Euro-score moyen était de 1,63±1% et le nombre moyen de pontage de 2,3±0,7. Les durées moyennes de la circulation extra-corporelle et du clampage aortique étaient respectivement de 134,4 ± 42 min et 76 ± 28 min. La mortalité hospitalière était de 2 décès (1,9%), les durées moyennes de ventilation artificielle, du séjour en réanimation et du séjour postopératoire étaient respectivement de 7h (5-16h), 48h (42-52h) et 15,6 ± 8,6 jours. Les complications postopératoires étaient l'infarctus du myocarde, l'infection de paroi, la médiastinite et le bas débit cardiaque chez respectivement 1,9%, 10,7%, 3,9% et 1,9% des patients. Il ressort de notre étude, que les facteurs prédictifs d'infection post opératoire étaient la durée de ventilation artificielle (p = 0,002), la durée de la circulation extra-corporelle (p < 0,001) en plus du tabac (p = 0,004) et de l'obésité (p = 0,005). Les patients ont été contactés par téléphone ou lors de la consultation régulière de contrôle. Le taux de suivi a atteint 92,1% et la survie à 2 ans était de 98,9% des patients contrôlés avec une mortalité tardive de 1% avec un décès suite à un accident vasculaire c

  13. Curiethérapie dans le traitement palliatif du cancer de l’œsophage

    PubMed Central

    Toulba, Ahmedou; Bakkali, Hanae; Boutayeb, Salwa; Kebdani, Tayeb; Ahid, Samir; Benjaafar, Noureddine

    2015-01-01

    Les patients atteints du cancer de l’œsophage ont souvent une maladie localement avancée, la dysphagie est le symptôme majeur chez la plupart de ces patients, plusieurs modalités thérapeutiques ont été utilisées pour améliorer cette dysphagie. Le but de ce travail est d’étudier l'efficacité et la tolérance de la curiethérapie haut débit de dose (HDR) endo-luminale dans le traitement palliatif des cancers de l’œsophage inopérable. Sur une période de 15 ans, l’étude a inclus les patients atteints de cancer de l’œsophage inopérable et/ou métastatique avec une dysphagie, sans extension à l'hypopharynx ou a la trachée et qui ont bénéficié d'une curiethérapie HDR avec ou sans radiothérapie externe à visée palliative. Au total 46 patients ont été inclus dans l’étude, 58,7% étaient des hommes, 42,2% avaient une dysphagie grade 2 et 37,8% étaient aphagiques, 78,6% des patients étaient performance satus PS 2, l'amaigrissement à été trouvé chez 81,4%, la localisation de la tumeur était surtout au niveau du tiers moyen et inférieur dans 97,8%, la hauteur médiane de la tumeur était de 7 cm (5,5-9), le carcinome épidermoïde était le type histologique le plus fréquent chez 31 patients (70,5%). Après un médiane de suivi de 5 mois, l'amélioration de la dysphagie a été retrouvée chez 76% des malades (p1]. L′incidence la plus élevée est observée dans certains pays notamment en Asie et en Afrique, et l′incidence dans les pays développés occidentaux est en augmentation [2]. Selon le registre du cancer de Rabat 2006-2008, le cancer de l’œsophage est rare et constitue 1,5% de tous les cancers chez l'homme [3]. Le taux de survie globale à 5 ans est de 8%, avec 80% des décès liés à l’évolution locale de la maladie [4]. Pour la minorité des patients avec une maladie localisée, le traitement par radiochimiothérapie concomitante avec ou sans chirurgie permet une amélioration de la survie [5]. Plus de 50

  14. Kyste hydatique du foie rompu dans la paroi abdominale et dans le muscle psoas : à propos d'une rare observation

    PubMed Central

    En-Nafaa, Issam; Moujahid, Mountassir; Alahyane, Abdelouahabe; Amil, Touria; Hanine, Ahmed; Ziadi, Tarik

    2011-01-01

    Le kyste hydatique du foie est une parasitose qui sévit à l′état endémique au maroc. La rupture dans la paroi abdominale et dans le psoas est une complication exceptionnelle. Nous rapportons un cas de kyste hydatique du foie rompu dans la paroi et dans le muscle psoas. Le diagnostic a été établi sur les données de l′échographie et surtout de la tomodensitométrie. Le patient a été opéré avec des suites simples. PMID:22187585

  15. Mise à jour sur le nouveau vaccin 9-valent pour la prévention du virus du papillome humain

    PubMed Central

    Yang, David Yi; Bracken, Keyna

    2016-01-01

    Résumé Objectif Informer les médecins de famille quant à l’efficacité, à l’innocuité, aux effets sur la santé publique et à la rentabilité du vaccin 9-valent contre le virus du papillome humain (VPH). Qualité des données Des articles pertinents publiés dans PubMed jusqu’en mai 2015 ont été examinés et analysés. La plupart des données citées sont de niveau I (essais randomisés et contrôlés et méta-analyses) ou de niveau II (études transversales, cas-témoins et épidémiologiques). Des rapports et recommandations du gouvernement sont aussi cités en référence. Message principal Le vaccin 9-valent contre le VPH, qui offre une protection contre les types 6, 11, 16, 18, 31, 33, 45, 52 et 58 du VPH, est sûr et efficace et réduira encore plus l’incidence des infections à VPH, de même que les cas de cancer lié au VPH. Il peut également protéger indirectement les personnes non immunisées par l’entremise du phénomène d’immunité collective. Un programme d’immunisation efficace peut prévenir la plupart des cancers du col de l’utérus. Les analyses montrent que la rentabilité du vaccin 9-valent chez les femmes est comparable à celle du vaccin quadrivalent original contre le VPH (qui protège contre les types 6, 11, 16 et 18 du VPH) en usage à l’heure actuelle. Toutefois, il faut investiguer plus en profondeur l’utilité d’immuniser les garçons avec le vaccin 9-valent contre le VPH. Conclusion en plus d’être sûr, le vaccin 9-valent protège mieux contre le VPH que le vaccin quadrivalent. Une analyse coûtefficacité en favorise l’emploi, du moins chez les adolescentes. Ainsi, les médecins devraient recommander le vaccin 9-valent à leurs patients plutôt que le vaccin quadrivalent contre le VPH.

  16. L'atteinte osseuse dans le sarcome de Kaposi classique et agressif: à propos d'un cas

    PubMed Central

    Sbiyaa, Mouhcine; El Alaoui, Adil; El Bardai, Mohammed; Mezzani, Amine; Lahrach, Kamal; Marzouki, Amine; Boutayeb, Fawzi

    2016-01-01

    Le sarcome de Kaposi classique est une tumeur rare multifocale d'origine des cellules endothéliales vasculaires à caractère évolutif progressif et peu maligne. L'atteinte viscérale dans le sarcome de kaposi est parfois observée chez les patients VIH positif par contre la dissémination tumorale dans les ganglions lymphatiques viscérales dans le SK classique reste très rare. On rapporte un cas rare de sarcome de kaposi classique agressif de la main avec une évolution rapide et destructive. PMID:27347285

  17. Les bisphosphonates dans le traitement de l’ostéoporose

    PubMed Central

    Brown, Jacques P.; Morin, Suzanne; Leslie, William; Papaioannou, Alexandra; Cheung, Angela M.; Davison, Kenneth S.; Goltzman, David; Hanley, David Arthur; Hodsman, Anthony; Josse, Robert; Jovaisas, Algis; Juby, Angela; Kaiser, Stephanie; Karaplis, Andrew; Kendler, David; Khan, Aliya; Ngui, Daniel; Olszynski, Wojciech; Ste-Marie, Louis-Georges; Adachi, Jonathan

    2014-01-01

    Résumé Objectif Exposer l’efficacité et les risques du traitement par les bisphosphonates dans la prise en charge de l’ostéoporose et décrire les patients qui seraient de bons candidats aux congés thérapeutiques. Qualité des données Une recherche dans MEDLINE (PubMed, jusqu’au 31 décembre 2012) a permis de relever les publications pertinentes pour l’inclusion. La plupart des données probantes citées sont de niveau II (tirées d’essais non randomisés, de cohorte et d’autres essais comparatifs). Message principal L’efficacité des bisphosphonates de premier recours homologués pour la prévention des fractures a été éprouvée dans le cadre d’essais cliniques randomisés et contrôlés. Cependant, l’usage clinique répandu et prolongé des bisphosphonates a donné lieu à des rapports de manifestations indésirables rares, mais graves. L’ostéonécrose maxillaire et les fractures atypiques sous-trochantériennes ou diaphysaires du fémur seraient liées à l’emploi des bisphosphonates dans le traitement de l’ostéoporose, mais ces manifestations sont extrêmement rares et lorsqu’elles surviennent, elles sont accompagnées d’autres comorbidités ou de l’emploi concomitant de médicaments. Les congés thérapeutiques ne peuvent être envisagés que chez les patients à faible risque et dans un groupe restreint de patients dont le risque de fracture est modéré après un traitement de 3 à 5 ans. Conclusion Lorsque les bisphosphonates sont prescrits à des patients dont le risque de fracture est élevé, leur effet de prévention des fractures l’emporte de loin sur leurs torts potentiels. Chez les patients qui prennent des bisphosphonates depuis 3 à 5 ans, il faut réévaluer le besoin de poursuivre le traitement.

  18. Calorimetric studies of the heats of protonation of the dangling phosphorus in [eta][sup 1]-Ph[sub 2]PCH[sub 2]PPh[sub 2] complexes of chromium, molybdenum, and tungsten

    SciTech Connect

    Rottink, M.K.; Angelici, R.J. )

    1993-05-26

    Titration calorimetry has been used to determine the heats of protonation ([Delta]H[sub HP]) of M(CO)[sub 5]([eta][sup 1]-dppm) (M = Cr, Mo, W) and fac-M(CO)[sub 3](N-N)([eta][sup 1]-dppm) (M = Mo, N-N = bipy, phen; M = w, N-N = bipy) complexes with CF[sub 3]SO[sub 3]H in 1,2-dichloroethane solvent at 25.0 [degrees]C. Spectroscopic studies show that protonation occurs at the uncoordinated phosphorus atom of the [eta][sup 1]-coordinated dppm (Ph[sub 2]PCH[sub 2]PPh[sub 2]) ligand. For dppm, its monoprotonated form (dppmH[sup +]), and these complexes, the basicity ([Delta]H[sub HP]) of the dangling phosphorus increases from -14.9 kcal/mol to -23.1 kcal/mol in the order: dppmH[sup +] le]fac-Mo(CO)[sub 3]([eta][sup 2]-bipy)([eta][sup 1]-dppm) < fac-Mo(CO)[sub 3]([eta][sup 2]-phen)([eta][sup 1]-dppm) [approx] fac-W(CO)[sub 3]([eta][sup 2]-bipy)([eta][sup 1]-dppm). In this series, H[sup +] is more electron-withdrawing than M(CO)[sub 5] (M = Cr, Mo, W); Mo(CO)[sub 3]([eta][sup 2]-phen) and W(CO)[sub 3]-([eta][sup 2]-bipy) actually enhance the basicity of the dangling phosphorus as compared with dppm itself. The basicity ([Delta]H[sub HM]) of fac-W(CO)[sub 3]([eta][sup 2]-bipy)(PPh[sub 2]Me), which protonates at the metal center to give a seven-coordinate complex, is -18.8 kcal/mol. Thus, the basicity of the dangling phosphorus atom in fac-W(CO)[sub 3]([eta][sup 2]-bipy)([eta][sup 1]-dppm) is approximately 4.3 kcal/mol more basic than the metal center.

  19. Overexpression of the Tomato Pollen Receptor Kinase LePRK1 Rewires Pollen Tube Growth to a Blebbing Mode[W][OPEN

    PubMed Central

    Gui, Cai-Ping; Dong, Xin; Liu, Hai-Kuan; Huang, Wei-Jie; Zhang, Dong; Wang, Shu-Jie; Barberini, María Laura; Gao, Xiao-Yan; Muschietti, Jorge; McCormick, Sheila

    2014-01-01

    The tubular growth of a pollen tube cell is crucial for the sexual reproduction of flowering plants. LePRK1 is a pollen-specific and plasma membrane–localized receptor-like kinase from tomato (Solanum lycopersicum). LePRK1 interacts with another receptor, LePRK2, and with KINASE PARTNER PROTEIN (KPP), a Rop guanine nucleotide exchange factor. Here, we show that pollen tubes overexpressing LePRK1 or a truncated LePRK1 lacking its extracellular domain (LePRK1ΔECD) have enlarged tips but also extend their leading edges by producing “blebs.” Coexpression of LePRK1 and tomato PLIM2a, an actin bundling protein that interacts with KPP in a Ca2+-responsive manner, suppressed these LePRK1 overexpression phenotypes, whereas pollen tubes coexpressing KPP, LePRK1, and PLIM2a resumed the blebbing growth mode. We conclude that overexpression of LePRK1 or LePRK1ΔECD rewires pollen tube growth to a blebbing mode, through KPP- and PLIM2a-mediated bundling of actin filaments from tip plasma membranes. Arabidopsis thaliana pollen tubes expressing LePRK1ΔECD also grew by blebbing. Our results exposed a hidden capability of the pollen tube cell: upon overexpression of a single membrane-localized molecule, LePRK1 or LePRK1ΔECD, it can switch to an alternative mechanism for extension of the leading edge that is analogous to the blebbing growth mode reported for Dictyostelium and for Drosophila melanogaster stem cells. PMID:25194029

  20. Measurement of probabilities for vacancy transfer from the K to L shell of the elements 73{le}Z{le}92

    SciTech Connect

    Ertugrul, M.; Dogan, O.; Simsek, O.; Turgut, U.; Erdogan, H.

    1997-01-01

    K- to L-shell vacancy transfer probabilities were measured for ten elements in the atomic range 73{le}Z{le}92. Those measuring L x-ray yields from targets excited by 59.5 and 122 keV incident photons, i.e., below and above the K edge of elements, were detected with a high-resolution Si(Li) detector. For comparison with experimental results, theoretical calculations were made by using available data on radiative and radiationless transitions. The radiative transitions of these elements were observed from the relativistic Hartree-Slater model which was proposed by Scofield [At. Data Nucl. Data Tables {bold 14}, 121 (1974)]. The radiationless transitions were observed from the Dirac-Hartree-Slater model which was proposed by Chen, Craseman, and Mark [At. Data Nucl. Data Tables {bold 24}, 13 (1979)]. The measured results were found to be in good agreement with theoretically calculated values. The experimental and theoretical values were fitted versus atomic number Z.

  1. The Potassium-Argon Laser Experiment (KArLE): In Situ Geochronology for Planetary Robotic Missions

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara

    2016-01-01

    The Potassium (K) - Argon (Ar) Laser Experiment (KArLE) will make in situ noble-gas geochronology measurements aboard planetary robotic landers and roverss. Laser-Induced Breakdown Spectroscopy (LIBS) is used to measure the K abun-dance in a sample and to release its noble gases; the evolved Ar is measured by mass spectrometry (MS); and rela-tive K content is related to absolute Ar abundance by sample mass, determined by optical measurement of the ablated volume. KArLE measures a whole-rock K-Ar age to 10% or better for rocks 2 Ga or older, sufficient to resolve the absolute age of many planetary samples. The LIBS-MS approach is attractive because the analytical components have been flight proven, do not require further technical development, and provide complementary measurements as well as in situ geochronology.

  2. La prise en charge d’une clientèle

    PubMed Central

    Roy, Andréanne; Breton, Mylaine; Loslier, Julie

    2016-01-01

    Résumé Objectif Analyser les facteurs qui incitent les médecins de famille nouvellement autorisés à faire de la prise en charge d’une clientèle en première ligne. Type d’étude Devis mixte séquentiel : questionnaire en ligne auto-administré auprès de médecins de famille, suivi d’entrevues individuelles. Contexte La Montérégie, qui est la deuxième région la plus populeuse du Québec, et qui présente des zones rurales et urbaines. Participants Tous les médecins de famille détenant un poste en Montérégie et ayant moins de 10 années d’expérience ont été sollicités, soit 366 médecins. Parmi eux, 118 ont complété le questionnaire en ligne (taux de réponse de 32,2 %). Parmi les répondants, 10 médecins ayant des profils de prise en charge variés ont été sélectionnés pour les entrevues individuelles. Principaux paramètres à l’étude Le pourcentage de temps de travail consacré à la prise en charge, analysé en parallèle avec différents facteurs facilitants et barrières à la prise en charge aux niveaux contextuel, organisationnel, du médecin de famille et de la clientèle. Résultats Les principaux facteurs facilitant la prise en charge sont la relation médecin-patient, l’intérêt pour les activités cliniques liées à la prise en charge, les modèles de rôles positifs, la collaboration avec une infirmière et l’accès adéquat aux ressources, notamment en santé mentale. Les principales barrières sont l’ampleur des tâches administratives, l’intérêt pour une pratique polyvalente, l’expérience négative de la prise en charge lors de la formation, un sentiment n’inaptitude à l’égard de la prise en charge, la lourdeur de la clientèle et le manque de soutien en début de pratique. Conclusion Certaines pistes de solution pour inciter les nouveaux médecins de famille à prendre en charge une clientèle sont proposées. Des points d’amélioration au niveau de la formation médicale, du soutien

  3. Le syndrome de Cri du Chat : A propos d’une observation

    PubMed Central

    Ouldim, Karim; Samri, Imane; Bouguenouch, Laila; Hamdaoui, Hasna; Otmani, Ihsan El; Hbibi, Mohamed; Chaouki, Sana; Hida, Moustapha

    2012-01-01

    Le syndrome du Cri du Chat (Cri du Chat syndrome, CdCS) est une anomalie chromosomique résultant d’une délétion de taille variable de l’extrémité du bras court du chromosome 5 (5p), incluant une région critique située en p15.2. Il représente une des délétions chromosomiques les plus fréquentes, son incidence dans la population générale est de 1/20 000 à 1/50 000. Les caractéristiques cliniques comprennent un cri monochromatique aigu, une microcéphalie, une dysmorphie cranio-faciale caractéristique évoluant avec l’âge et un retard mental et psychomoteur important. La taille de la délétion est variable, Le traitement est fonction des différents symptômes. Un remaniement chromosomique parental est retrouvé dans 12% des cas et la majorité des délétions responsables de la maladie du cri-du-chat surviennent de novo. Nous présentons une observation d’un syndrome du Cri du Chat, confirmé par caryotype métaphasique (46,XY,del(5)(p13) de novo). A travers cette observation nous mettrons à jour, les actualités scientifiques de ce rare syndrome, ainsi que la place des explorations cytogénétiques dans le diagnostic précis et le conseil génétique des syndromes dysmorphiques. PMID:22368747

  4. Magnétométrie à hélium par pompage laser: le bilan

    NASA Astrophysics Data System (ADS)

    Gilles, H.; Hamel, J.; Monfort, Y.

    2002-06-01

    Depuis 1986, l'équipe Physique Atomique et Capteurs du CIRIL-ISMRA de Caen étudie les magnétomètres à hélium par pompage laser. On présente ici le bilan de ces travaux de recherche et les performances des deux prototypes (hélium4 et hélium3) réalisés au Laboratoire.

  5. Neurological and psychological constructs in Sheridan Le Fanu's In a Glass Darkly.

    PubMed

    Ginn, Sheryl R

    2013-01-01

    Excepting "Green Tea" and "Carmilla," Sheridan Le Fanu's fiction is generally neglected by modern-day readers, yet his work reveals much information about the conduct of life in nineteenth century Ireland and England. Le Fanu's works should be appreciated for the insights he provides into the psychology of his characters; his fiction was written prior to what historians of psychology date as the formal establishment of the discipline in 1879, which occurred after his death. His fiction also illustrates the emerging medical specialty of neurology, although Le Fanu's later writings are more illustrative of his interest in the mystical works of Emanuel Swedenborg. His characters frequently suffer from "brain fevers" and other maladies that were the subject of intense debate in England, continental Europe, and America. His male characters in particular suffer from guilty consciences, and suicide is a frequent fate. Each of these aspects of Le Fanu's fiction can be found in the 1872 collection In a Glass Darkly, which purports to contain five case histories of the German metaphysical physician Doctor Martin Hesselius. In this chapter, each of the stories in the collection will be described and analyzed for Hesselius' use of psychological, neurological, or mystical explanations for the events occurring within the story. Hesselius' descriptions of psychological constructs are rather advanced for a physician discussing mental disorders in the nineteenth century. His theories within this collection of stories with respect to neurology and neuroscience, on the other hand, are much more representative of the eighteenth century, something that would be natural given that the stories contained in the collection were purported to have occurred in the latter decades of the eighteenth or early decades of the nineteenth century. PMID:24290262

  6. Development of the Potassium-Argon Laser Experiment (KArLE) Instrument for In Situ Geochronology

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara A.; Li, Z.-H.; Miller, J. S.; Brinckerhoff, W. B.; Clegg, S. M.; Mahaffy, P. R.; Swindle, T. D.; Wiens, R. C.

    2012-01-01

    Absolute dating of planetary samples is an essential tool to establish the chronology of geological events, including crystallization history, magmatic evolution, and alteration. Traditionally, geochronology has only been accomplishable on samples from dedicated sample return missions or meteorites. The capability for in situ geochronology is highly desired, because it will allow one-way planetary missions to perform dating of large numbers of samples. The success of an in situ geochronology package will not only yield data on absolute ages, but can also complement sample return missions by identifying the most interesting rocks to cache and/or return to Earth. In situ dating instruments have been proposed, but none have yet reached TRL 6 because the required high-resolution isotopic measurements are very challenging. Our team is now addressing this challenge by developing the Potassium (K) - Argon Laser Experiment (KArLE) under the NASA Planetary Instrument Definition and Development Program (PIDDP), building on previous work to develop a K-Ar in situ instrument [1]. KArLE uses a combination of several flight-proven components that enable accurate K-Ar isochron dating of planetary rocks. KArLE will ablate a rock sample, determine the K in the plasma state using laser-induced breakdown spectroscopy (LIBS), measure the liberated Ar using quadrupole mass spectrometry (QMS), and relate the two by the volume of the ablated pit using an optical method such as a vertical scanning interferometer (VSI). Our preliminary work indicates that the KArLE instrument will be capable of determining the age of several kinds of planetary samples to +/-100 Myr, sufficient to address a wide range of geochronology problems in planetary science.

  7. Transforming properties of the cottontail rabbit papillomavirus oncoproteins Le6 and SE6 and of the E8 protein.

    PubMed Central

    Harry, J B; Wettstein, F O

    1996-01-01

    Cottontail rabbit papillomavirus induces on cottontail and domestic rabbits papillomas which progress at a high frequency to carcinoma. The virus encodes three transforming proteins; one is translated from open reading frame (ORF) E7 and binds the retinoblastoma protein, and two, LE6 and SE6, are translated from the first and second ATGs of ORF E6, respectively. Here we show that neither of the E6 proteins coprecipitated with p53 in vitro, nor did they bind to a recently identified E6-binding protein (J. J. Chen, C. E. Reid, V. Band, and E. Androphy, Science 269:529-531, 1995). This protein was shown to bind to the E6 proteins of the high-risk human papillomairus types 16 and 18 but not to the low-risk human papillomavirus types VI and II. In-frame deletions cloned into the pZipNeo vector were used to identify structural features of SE6 and LE6 important for transformation of NIH 3T3 cells. Three deletions covering the amino-terminal half of SE6 did not transform cells. In two of the three deletions, two Cys-X-X-Cys motifs were deleted, each deletion preventing the formation of one of the potential small Zn fingers of SE6. Among the LE6 deletions, only one had a reduced transformation efficiency, while seven transformed cells at least as efficiently as wild-type LE6. In each of three of these seven mutants, two Cys-X-X-Cys motifs were deleted. None of the three amino acid deletions which abolished transformation by SE6 reduced transformation by LE6. Furthermore, transformation did not correlate with the level of SE6 or LE6 proteins detectable. ORF E8 colinear with ORF E6, which could generate a 50-amino-acid protein with a hydrophobic segment, did not transform cells when cloned into the pZipNeo vector. However, mutation of the E8 ATG, which did not alter the amino acid sequence of LE6, increased transformation by LE6 without affecting the level of LE6 expression. The data suggest that transformation by the E6 proteins is not mediated by interfering with p53

  8. Profil évolutif et pronostic des tumeurs urothéliales de la vessie chez le sujet jeune

    PubMed Central

    Bouzouita, Abderrazak; Saadi, Ahmed; Kerkeni, Walid; Chakroun, Marouene; Cherif, Mohamed; Ayed, Haroun; Selmi, Selim; Derouiche, Amine; Benslama, Riadh Mohamed; Chebil, Mohamed

    2016-01-01

    Résumé But: Les tumeurs urothéliales de la vessie sont rares chez le jeune adulte. Leur profil évolutif et leur pronostic restent matière à contro-verse. Nous rapportons notre expérience à propos de 54 patients. Méthodologie: Entre 1990 et 2010, 54 patients de moins de 40 ans au moment du diagnostic ont été traités pour carcinome à cellules transitionnelles de la vessie. Nous avons étudié le profil évolutif de ces tumeurs en séparant les patients en deux groupes (moins de 30 ans, et 30 à 40 ans). Résultats: La tumeur n’infiltrait pas le muscle vésical dans 37 cas et l’infiltrait dans 17 cas. Pour les tumeurs n’infiltrant pas le muscle vésical, elles étaient de stade Ta dans 20 cas et de grade I–II dans 36 cas. Le pronostic de ces tumeurs était meilleur avant l’âge de 30 ans avec un taux de récidive de 15,3 % sans progression. Pour les patients de 30 à 40 ans, le taux de récidive était de 33,3 %, et 25 % des tumeurs qui ont récidivé ont présenté une progression du stade. Pour les tumeurs infiltrant le muscle vésical, le pronostic était sombre (localement avancées dans neuf cas et métastatiques d’emblée dans cinq cas). Conclusion: Le profil évolutif des tumeurs n’infiltrant pas le muscle vésical a semblé meilleur avant l’âge de 30 ans. Entre 30 et 40 ans, le profil évolutif s’est approché de celui des sujets âgés. Les tumeurs infiltrantes étaient souvent évoluées et agressives, évoquant un potentiel évolutif particulier. PMID:27330577

  9. SCaLeM: A Framework for Characterizing and Analyzing Execution Models

    SciTech Connect

    Chavarría-Miranda, Daniel; Manzano Franco, Joseph B.; Krishnamoorthy, Sriram; Vishnu, Abhinav; Barker, Kevin J.; Hoisie, Adolfy

    2014-10-13

    As scalable parallel systems evolve towards more complex nodes with many-core architectures and larger trans-petascale & upcoming exascale deployments, there is a need to understand, characterize and quantify the underlying execution models being used on such systems. Execution models are a conceptual layer between applications & algorithms and the underlying parallel hardware and systems software on which those applications run. This paper presents the SCaLeM (Synchronization, Concurrency, Locality, Memory) framework for characterizing and execution models. SCaLeM consists of three basic elements: attributes, compositions and mapping of these compositions to abstract parallel systems. The fundamental Synchronization, Concurrency, Locality and Memory attributes are used to characterize each execution model, while the combinations of those attributes in the form of compositions are used to describe the primitive operations of the execution model. The mapping of the execution model’s primitive operations described by compositions, to an underlying abstract parallel system can be evaluated quantitatively to determine its effectiveness. Finally, SCaLeM also enables the representation and analysis of applications in terms of execution models, for the purpose of evaluating the effectiveness of such mapping.

  10. Soft tissue changes and skeletal stability after modified quadrangular Le Fort I osteotomy.

    PubMed

    Lee, H-J; Park, H-S; Kyung, H-M; Kwon, T-G

    2015-03-01

    The purpose of this study was to evaluate the soft tissue changes and skeletal stability of a modification of the Le Fort I osteotomy design - the modified quadrangular Le Fort I osteotomy (MQLI). Patients who had maxillary advancement and mandibular setback surgery for skeletal class III malocclusion with a midface deficiency were included. MQLI patients (n=20) were compared to conventional Le Fort I osteotomy patients (LFI) (n=20) using cephalometric radiographs taken preoperatively (T0), immediately postoperative (T1), and at >6 months postoperative (T2). Soft tissue radiographic changes of the cheek line and perinasal areas, and skeletal movements were analyzed. The basic skeletal characteristics and amount of maxillary and mandibular surgical change were similar in the two groups (group difference, P>0.05). There was no significant difference between the two groups in terms of maxillary and mandibular skeletal stability. The cheek profile angle increased significantly after MQLI by 3.5° (P<0.05), whereas LFI showed a 2.1° increase (P>0.05). Overall, the soft tissue cheek outline moved significantly more anteriorly in MQLI, but the difference to LFI osteotomy did not reach statistical significance. MQLI could be an efficient and stable surgical method to improve maxillary and infraorbital hypoplasia without malar advancement, especially in Asian patients. PMID:25467738

  11. Une formation à la recherche en médecine transfusionnelle dans le monde francophone

    PubMed Central

    Shiboski, C.; Fontanet, A.; Murphy, E.L.

    2010-01-01

    Un enseignement accéléré et francophone de formation à la recherche en médecine transfusionnelle a été récemment instauré à l’Institut Pasteur de Paris, sous la codirection de membres hospitalo-universitaires de l’université de Californie San Francisco (UCSF), du Blood Systems Research Institute (BSRI) et de l’Institut national de la transfusion sanguine (INTS). Le but est de former des professionnels de la transfusion des pays en voie de développement à mener une activité de recherche dont les résultats peuvent contribuer à un renforcement de la qualité des soins transfusionnels et de la sécurité transfusionnelle dans leur pays. Le cours enseigne les méthodes de recherche clinique et épidémiologique, et leurs applications transfusionnelles potentielles. Chaque étudiant élabore au cours du stage un protocole personnel de recherche, qu’il lui sera loisible de mettre ensuite en pratique dans le centre de transfusion ou l’hôpital où il exerce. PMID:19640755

  12. Contrôle d'une machine asynchrone par estimation robuste de la vitesse

    NASA Astrophysics Data System (ADS)

    Roboam, X.; Hapiot, J. C.; de Fornel, B.; Andrieux, C.

    1992-03-01

    This paper describes the study and the implementation of a variable speed drive for induction motor with no mechanical sensor. Power is supplied by a current-controlled voltage-source inverter. The lack of information (only two line-current sensors) requires an accurate and reliable reconstitution of the main quantities not sensed (flux, speed, torque). The results obtained show the excellent quality of the estimated speed, whatever the operating condition and despite the perturbations applied to the system. This study finally leads to the construction of a prototype. Cet article décrit l'étude et la mise en oeuvre d'un variateur de vitesse pour machine asynchrone sans capteur mécanique et alimentée par un onduleur de tension cotrôlé en courant. Le manque d'information (2 capteurs de courants de ligne uniquement) nécessite la reconstitution fiable et précise des grandeurs fondamentales non mesurées (flux, vitesse, couple). Les résultats obtenus montrent notamment l'excellente qualité de l'estimation de vitesse, quel que soit le point de fonctionnement et en dépit des perturbations auxquelles le système est soumis. Cette étude donne lieu à la réalisation d'un variateur prototype.

  13. Cultural Heritage Protection Issues In Leśnica, The Settlement Of Wrocław

    NASA Astrophysics Data System (ADS)

    Kononowicz, Alena

    2015-09-01

    Leśnica, today the settlement on the western edge of Wrocław, formerly was an independent town, located on a previously wooded area, with a linear street system. It developed in the Middle Ages around the castle and church playing a service role for the Silesian Piast court on their way to Legnica and during hunting. In the thirteenth century it received city rights, and lost them in the eighteenth century. After the Piast dynasty had died out, it was sold by John of Luxembourg, and repeatedly changed its owners. In the nineteenth century it developed thanks to the industry, tourism and a convenient railway connection to Wrocław as well as hotel and restaurant facilities. In 1928, Leśnica was incorporated into Wrocław. After the Second World War, it lost its cultural continuity. In the 1970's, middle-heigh and high prefabricated buildings were built in the vicinity of a residential district. At the end of the twentieth and early twenty-first century, local industries were liquidated, and intensive land development started, causing the systematic blurring of its small-town character and its urban space started to acquire a character of a big city. In 2004, the old part of Leśnica was entered in the Register of Monuments. Also a ring road was planned, moving the cumbersome and dangerous transit traffic away from historic Średzka Street beyond the southern border of the settlement.

  14. Mucocèle appendiculaire: à propos d'un cas observé à Lubumbashi

    PubMed Central

    Wakunga, Eric; Mukuku, Olivier; Bugeme, Marcellin; Tshiband, Moïse; Kipili, Audifax; Mobambo, Pitchou; Arung, Willy; Wakunga, Warach

    2014-01-01

    La mucocèle appendiculaire est une entité pathologique rare, mais potentiellement dangereuse, elle se présente sous différentes formes cliniques. Nous rapportons ici un cas d'une patiente âgée de 49 ans sans antécédents chirurgicaux chez qui nous avons découvert d'une façon fortuite cette affection. La clinique était celle d'un syndrome appendiculaire aigu patent et elle révélait une masse dans la fosse iliaque droite. Les examens de laboratoire ont montré une hyperleucocytose et une vitesse de sédimentation augmentée. L’échographie a démontré une masse kystique péricaecal. La patiente a subi une appendicectomie avec cæcectomie partielle et la pièce opératoire appendiculaire mesurait 153 mm de longueur et 64 mm de diamètre. L'analyse anatomopathologique de celle-ci a confirmé le diagnostic de mucocèle appendiculaire sans cellules de malignité. Les suites opératoires ont été simples et la patiente est sortie au cinquième jour postopératoire. PMID:25368725

  15. Stability of Le Fort I Osteotomy With Propeller Graft for Canting Correction in Facial Asymmetry.

    PubMed

    Lee, Jae-Yeol; Kim, Yong-Il; Kang, Hee-Jea; Song, Jae-Min; Park, Soo-Byung; Kim, Jong-Ryoul

    2015-10-01

    The aim of this study was to evaluate the maxillary stability in patients who had undergone Le Fort I osteotomy with propeller graft and mandibular sagittal split ramus osteotomy for correction of maxillary asymmetry. This was a retrospective study on 15 facial asymmetry patients (7 men, 8 women: 22.2 years) requiring surgical correction at the preoperative (T0), immediately postoperative (T1) and 6 months after surgery (T2) stages. To evaluate the skeletal stability, computed tomography (CT) superimposition was used, and skeletal landmarks were measured and compared from the superimposed images according to an x, y, z coordinate system. The skeletal changes at each stage (ΔT1-T0 and ΔT2-T1) were compared by paired t-test (P<0.05). The obtained data on the skeletal changes immediately postoperatively to 6-month follow-up (ΔT2-T1) showed that the Le Fort I osteotomy with propeller graft had effected stable maxillary skeletal stability at the maxillary measurement points (posterior nasal spine (PNS ), nasopalatine canal, U3 crown tip, U3 root apex, and U6 furcation). These results suggested that in cases of facial asymmetry where the upper tooth exposure is proper and anterior-posterior movement of the maxilla is not much required, Le Fort I osteotomy with propeller graft is an effective method for stable canting correction. PMID:26468788

  16. The NASA LeRC regenerative fuel cell system testbed program for goverment and commercial applications

    SciTech Connect

    Maloney, T.M.; Voecks, G.E.

    1995-01-25

    The Electrochemical Technology Branch of the NASA Lewis Research Center (LeRC) has initiated a program to develop a renewable energy system testbed to evaluate, characterize, and demonstrate fully integrated regenerative fuel cell (RFC) system for space, military, and commercial applications. A multi-agency management team, led by NASA LeRC, is implementing the program through a unique international coalition which encompasses both government and industry participants. This open-ended teaming strategy optimizes the development for space, military, and commercial RFC system technologies. Program activities to date include system design and analysis, and reactant storage sub-system design, with a major emphasis centered upon testbed fabrication and installation and testing of two key RFC system components, namely, the fuel cells and electrolyzers. Construction of the LeRC 25 kW RFC system testbed at the NASA-Jet Propulsion Labortory (JPL) facility at Edwards Air Force Base (EAFB) is nearly complete and some sub-system components have already been installed. Furthermore, planning for the first commercial RFC system demonstration is underway. {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}

  17. Genetic resistance in experimental autoimmune encephalomyelitis. I. Analysis of the mechanism of LeR resistance using radiation chimeras

    SciTech Connect

    Pelfrey, C.M.; Waxman, F.J.; Whitacre, C.C. )

    1989-09-01

    Experimental autoimmune encephalomyelitis (EAE) is a cell-mediated autoimmune disease of the central nervous system that has been extensively studied in the rat. The Lewis rat is highly susceptible to the induction of EAE, while the Lewis resistant (LeR) rat is known to be resistant. In this paper, we demonstrate that the LeR rat, which was derived from the Lewis strain by inbreeding of fully resistant animals, is histocompatible with the Lewis strain. Radiation chimeras, a tool for distinguishing between immunologic and nonimmunologic resistance mechanisms, were utilized to analyze the cellular mechanisms involved in genetic resistance to EAE. By transplanting bone marrow cells from LeR rats into irradiated Lewis recipients, Lewis rats were rendered resistant to EAE induction. Likewise, transplanting Lewis bone marrow cells into irradiated LeR recipients rendered LeR rats susceptible. Mixed lymphoid cell chimeras using bone marrow, spleen, and thymus cells in Lewis recipient rats revealed individual lymphoid cell types and cell interactions that significantly affected the incidence and severity of EAE. Our results suggest that LeR resistance is mediated by hematopoietic/immune cells, and that cells located in the spleen appear to play a critical role in the resistance/susceptibility to EAE induction. Depletion of splenic adherent cells did not change the patterns of EAE resistance. In vivo cell mixing studies suggested the presence of a suppressor cell population in the LeR spleen preparations which exerted an inhibitory effect on Lewis autoimmune responses. Thus, the mechanism of LeR resistance appears to be different from that in other EAE-resistant animals.

  18. Navigation-assisted Le Fort I osteotomy with midpalatal split to treat compressive pathologies of the craniovertebral junction.

    PubMed

    Sándor, George K; Korpi, Jarkko T; Ylikontiola, Leena P; Salokorpi, Niina; Katisko, Jani; Kumpulainen, Timo

    2013-02-01

    This report describes the management of the case of an 11-year-old girl with serious compressive pathology of the craniocervical junction using a navigation-guided Le Fort I level maxillotomy and midline split. In this pediatric case, image guidance significantly enhanced intraoperative orientation and helped to determine the correct location of the horizontal osteotomy lines at the Le Fort I level. PMID:23351765

  19. Troubles psychotiques précipités par le mariage : étude de trois observations

    PubMed Central

    Jaweher, Masmoudi; Kammoun, Mohamed Faouzi; Inès, Feki; Imen, Baati; Rim, Sallami; Abdelaziz, Jaoua

    2013-01-01

    Le mariage est un évènement très investi dans notre culture arabo-musulmane. Il présente une situation à grande charge émotionnelle et ayant un vécu stressant. C'est ainsi qu'il peut être à l'origine de la décompensation de certains troubles psychiatriques. Ce moment particulier de déclenchement de la pathologie peut altérer significativement l'adaptation familiale et sociale du patient en question, le rendant dépendant en partie ou en totalité à une institution. Dans ce travail, nous proposons d’étudier certains facteurs psychiques, sociaux et culturels pouvant aboutir à la précipitation des manifestations psychotiques par le mariage. Il s'agit de l’étude de trois observations cliniques, deux hommes et une femme, hospitalisés dans le service de psychiatrie A du CHU Hédi Chaker de Sfax et qui ont développés des manifestations psychotiques de façon concomitante à leur mariage. La durée moyenne de survenue des crises a été de vingt ans, le diagnostic retenu a été celui de trouble bipolaire dans deux cas et d'une schizophrénie indifférenciée chez le troisième patient. L’évolution s'est faite vers une chronicisation de deux malades et une dépendance institutionnelle dans le troisième cas. La précipitation des troubles psychotiques par le mariage, reste un phénomène en relation intime avec les composantes culturelles, elles-mêmes sont déterminantes dans la prise en charge ultérieure de ces patients. PMID:23785551

  20. Overexpression of a Homeobox Gene, LeT6, Reveals Indeterminate Features in the Tomato Compound Leaf1

    PubMed Central

    Janssen, Bart-Jan; Lund, Lance; Sinha, Neelima

    1998-01-01

    The cultivated tomato (Lycopersicon esculentum) has a unipinnate compound leaf. In the developing leaf primordium, major leaflet initiation is basipetal, and lobe formation and early vascular differentiation are acropetal. We show that engineered alterations in the expression of a tomato homeobox gene, LeT6, can cause dramatic changes in leaf morphology. The morphological states are variable and unstable and the phenotypes produced indicate that the tomato leaf has an inherent level of indeterminacy. This is manifested by the production of multiple orders of compounding in the leaf, by numerous shoot, inflorescence, and floral meristems on leaves, and by the conversion of rachis-petiolule junctions into “axillary” positions where floral buds can arise. Overexpression of a heterologous homeobox transgene, kn1, does not produce such phenotypic variability. This indicates that LeT6 may differ from the heterologous kn1 gene in the effects manifested on overexpression, and that 35S-LeT6 plants may be subject to alterations in expression of both the introduced and endogenous LeT6 genes. The expression patterns of LeT6 argue in favor of a fundamental role for LeT6 in morphogenesis of leaves in tomato and also suggest that variability in homeobox gene expression may account for some of the diversity in leaf form seen in nature. PMID:9662520

  1. le hydatiforme partielle invasive et métastatique: à propos d'un cas

    PubMed Central

    Lazrak, Ikram; Ihssane, Hakimi; Babahabib, Moulay Abdellah; Kouach, Jaouad; El Ochi, Mohamed Reda; Moussaoui, Moulay Driss; Dehayni, Mohamed

    2014-01-01

    Depuis plusieurs années, la môle hydatiforme partielle(MHP) a été considérée comme une entité bénigne qui ne nécessite pas une surveillance stricte comme celle de la môle complète(MC), mais l'apparition de quelques cas sporadiques de transformation de la môle partielle en maladie trophoblastique persistante que ça soit une môle invasive ou choriocarcinome ou voire même une tumeur du site d'implantation placentaire; a remis en question cette stratégie. A travers une observation d'une môle partielle invasive métastatique, et à travers une revue de la littérature, on a essayé d'appuyer cette conduite qui considère la môle partielle comme une pathologie potentiellement grave nécessitant une prise en charge adéquate et une surveillance assez rigoureuse. PMID:25815096

  2. Tissue-specific expression of Le(Y) antigen in high endothelial venules of human lymphoid tissues.

    PubMed

    Tanegashima, A; Ushiyama, I; Nishi, K; Yamamoto, H; Fukunaga, T

    1999-12-01

    In this study, we demonstrated that the anti-Le(Y) antibody (BM-1) especially reacted with high endothelial venules (HEVs) in peripheral lymph nodes of blood group O individuals. The Le(Y) expression on HEVs showed a unique tissue-specific pattern, i.e., a large amount of the Le(Y) expression in peripheral lymph nodes and no or small amounts in mesenteric lymph node. Statistical analysis showed that there was the significant difference between the percentage of Le(Y)-positive HEVs in peripheral lymph nodes and mesenteric lymph nodes. No expression of Le(Y) was observed in vessels of Payer's patch, thymus, spleen and other non-lymphoid organs. In blood group A or B individuals, the reactivity between HEVs and anti-Le(Y) antibody increased after enzyme digestion with alpha-N-acetylgalactosaminidase or alpha-galactosidase. These findings show that the expression of difucosylated blood group ABH antigens are especially expressed on HEVs in peripheral lymph nodes. Furthermore, the tissue-specific pattern suggests that these antigens may be related to intercellular adhesion between lymphocytes and HEVs. PMID:11133021

  3. Modèle simplifié du comportement hygrothermique d'un chai

    NASA Astrophysics Data System (ADS)

    Battaglia, J.-L.; Jomaa, W.; Gounot, J.

    1996-11-01

    Coupling between heat and moisture is often important for some kind of buildings. It is the case for wine and spirit storehouse for the breeding of wine in cask. Without strong assumptions, the knowledge model is too complex is regard to the formulation and the resolution of the equations. In this work, we develop a simplified model based on a preliminary study of the concerned building. For the resolution, an algorithm, adapted to our configuration, is proposed. Assumptions are proved with respect to experimental measurements of temperature and relative moisture, for two periods of the year. A sensitivity analysis of the model to some parameters is carried out. Finally, an implementation of the model, to estimate the quantity of wine lost by evaporation during one year, is presented. Le couplage entre chaleur et humidité est souvent important dans certains types de bâtiment et ne permet pas de traiter les deux transferts indépendamment l'un de l'autre. C'est le cas des chais où se déroule l'élevage du vin en barriques. Sans hypothèses fortes, la prise en compte du couplage hygrothermique donne alors lieu à une modélisation complexe tant au point de vue de sa formulation que la résolution des équations. Dans ce travail, nous développons un modèle simplifié, basé sur une étude préliminaire du bâtiment considéré. Un algorithme de résolution, adapté à la configuration étudiée, est proposé. Les hypothèses de modélisation sont validées à partir de relevés expérimentaux de température et d'humidité, réalisés sur deux périodes de l'année. Une étude de sensibilité du modèle à certains paramètres est menée. Enfin, une application du modèle, pour l'évaluation de la quantité de vin évaporée sur une année, est présentée.

  4. Programmable lithography engine (ProLE) grid-type supercomputer and its applications

    NASA Astrophysics Data System (ADS)

    Petersen, John S.; Maslow, Mark J.; Gerold, David J.; Greenway, Robert T.

    2003-06-01

    There are many variables that can affect lithographic dependent device yield. Because of this, it is not enough to make optical proximity corrections (OPC) based on the mask type, wavelength, lens, illumination-type and coherence. Resist chemistry and physics along with substrate, exposure, and all post-exposure processing must be considered too. Only a holistic approach to finding imaging solutions will accelerate yield and maximize performance. Since experiments are too costly in both time and money, accomplishing this takes massive amounts of accurate simulation capability. Our solution is to create a workbench that has a set of advanced user applications that utilize best-in-class simulator engines for solving litho-related DFM problems using distributive computing. Our product, ProLE (Programmable Lithography Engine), is an integrated system that combines Petersen Advanced Lithography Inc."s (PAL"s) proprietary applications and cluster management software wrapped around commercial software engines, along with optional commercial hardware and software. It uses the most rigorous lithography simulation engines to solve deep sub-wavelength imaging problems accurately and at speeds that are several orders of magnitude faster than current methods. Specifically, ProLE uses full vector thin-mask aerial image models or when needed, full across source 3D electromagnetic field simulation to make accurate aerial image predictions along with calibrated resist models;. The ProLE workstation from Petersen Advanced Lithography, Inc., is the first commercial product that makes it possible to do these intensive calculations at a fraction of a time previously available thus significantly reducing time to market for advance technology devices. In this work, ProLE is introduced, through model comparison to show why vector imaging and rigorous resist models work better than other less rigorous models, then some applications of that use our distributive computing solution are shown

  5. Le Conte's sparrows breeding in Conservation Reserve Program fields: precipitation and patterns of population change

    USGS Publications Warehouse

    Igl, L.D.; Johnson, D.H.

    1999-01-01

    The climate of the North American Great Plains is highly dynamic, with great year-to-year variability in precipitation and periodic, often extreme, wet and dry cycles (Bragg 1995). Drought is a major force of ecological disturbance on the Great Plains and has played a key role in directing the evolution of the grassland biota of this region (Knopf and Samson 1997). Although grassland birds may differ in their responses to enviromenental variations (Rotenberry and Wiens 1991), climatic variability and concomitant unpredictability of resources strongly influence populations of grassland birds across space and time (Wiens 1974, 1986; Cody 1985). Not surprisingly, breeding bird populations on the Great Plains are highly dynamic, exhibiting considerable annual variation in composition, abundance, and distribution (Johnson and Grier 1988, George et al. 1992, Zimmerman 1992, Igl and Johnson 1997). Recently, interest in grassland birds has increased with the recognition that many species are declining both continentally (Droege and Sauer 1994) and globally (Goriup 1988). Identification of the specific factors associated with grassland bird declines in North America, however, remains largely enigmatic (Herkert 1997), and it is complicated by the considerable annual fluctuations in grassland bird distribution and abundance (Igl and Johnson 1997). Although there is evidence that land-use changes on the breeding grounds may have contributed to grassland bird declines (e.g., Igl and Johnson 1997), there also is an indication that long-term drought conditions may have influenced recent population changes of some breeding birds on the Great Plains (Droege and Sauer 1989, Peterjohn and Sauer 1993, Bethke and Nudds 1995, Igl and Johnson 1997). Le Conte's Sparrow (Ammodramus leconteii) is a secretive grassland bird that breeds in central and southern Canada and the northcentral United States (Murray 1969). It winters primarily in the southern United States (Peterson 1980, 1990

  6. Les accidents de scooter chez l'enfant au CHU Aristide Le Dantec de Dakar: à propos de 74 cas

    PubMed Central

    Mohamed, Azhar Salim; Ngom, Gabriel; Sow, Mamadou; Mbaye, Papa Alassane; Camara, Souleymane; Seck, Ndeye Fatou; Ndour, Oumar

    2016-01-01

    Introduction Les accidents de scooter sont de plus en plus fréquents à Dakar. Le but de ce travail est de rapporter les aspects épidémiologiques et lésionnels des ces accidents chez l'enfant à Dakar. Méthodes Une étude rétrospective et descriptive a été menée dans le Service de Chirurgie Pédiatrique du CHU Aristide Le Dantec de Dakar entre le 1er janvier 2009 et le 31 décembre 2011. Nous avons étudié divers paramètres dont la fréquence, les aspects sociodémographiques et lésionnels. Résultats Les accidents de scooter représentaient 12% des accidents de la voie publique. Ils étaient fréquents entre 12 heures et 14 heures (27%) et entre 18 heures et 20 heures (28,4%). Ils pouvaient survenir tous les jours et étaient fréquents pendant les mois d'avril (17,6%) et de juin (13,5%). Ils survenaient essentiellement dans la périphérie de Dakar (78%). La tranche de 3 à 8 ans (60,8%) était la plus touchée. Le sexe masculin était prédominant (sexe ratio de 1,5). Les piétons étaient les plus vulnérables (93,2%). La chute était le mécanisme dominant (98,7%). Les lésions touchaient surtout le membre inférieur (51,1%) et étaient constituées essentiellement de fracture. Conclusion La fréquence des accidents de scooter chez l'enfant est liée à l'urbanisation galopante et à l'accroissement du parc automobile dans une presqu’île. Les victimes sont essentiellement des piétons et présentent le plus souvent des fractures. PMID:27200137

  7. Contrôle de l'orientation et de l'alignement moléculaire par un train d'impulsions soudaines

    NASA Astrophysics Data System (ADS)

    Sugny, D.

    2006-10-01

    Les récents progrès technologiques dans le domaine des Lasers permettent d'envisager le contrôle de nombreux processus quantiques jouant un rôle dans une variété de problèmes s'étendant de la réactivité chimique à l'information quantique. Dans ce contexte, nous nous sommes intéressés au contrôle de l'orientation ou de l'alignement moléculaire en utilisant un train d'impulsions soudaines. Nous avons défini des états cibles qui maximisent à la fois l'orientation ou l'alignement et sa durée dans le temps et montré comment atteindre ces états à l'aide de stratégie systématique ou optimisée

  8. Le domaine des co-infections et des maladies concomitantes du Réseau canadien pour les essais VIH des IRSC : lignes directrices canadiennes pour la prise en charge et le traitement de la co-infection par le VIH et l’hépatite C chez les adultes

    PubMed Central

    Hull, Mark; Giguère, Pierre; Klein, Marina; Shafran, Stephen; Tseng, Alice; Côté, Pierre; Poliquin, Marc; Cooper, Curtis

    2014-01-01

    HISTORIQUE : De 20 % à 30 % des Canadiens qui vivent avec le VIH sont co-infectés par le virus de l’hépatite C (VHC), lequel est responsable d’une morbidité et d’une mortalité importantes. La prise en charge du VIH et du VHC est plus complexe en raison de l’évolution accélérée de la maladie hépatique, du choix et des critères d’initiation de la thérapie antirétrovirale et du traitement anti-VHC, de la prise en charge de la santé mentale et des toxicomanies, des obstacles socioéconomiques et des interactions entre les nouvelles thérapies antivirales à action directe du VHC et les antirétroviraux OBJECTIF : Élaborer des normes nationales de prise en charge des adultes co-infectés par le VHC et le VIH dans le contexte canadien. MÉTHODOLOGIE : Le Réseau canadien pour les essais VIH des Instituts de recherche en santé du Canada a réuni un groupe d’experts possédant des compétences cliniques en co-infection par le VIH et le VHC pour réviser les publications à jour ainsi que les lignes directrices et les protocoles en place. Après une vaste sollicitation afin d’obtenir des points de vue, le groupe de travail a approuvé des recommandations consensuelles, qu’il a caractérisées au moyen d’une échelle de qualité des preuves fondée sur la classe (bienfaits par rapport aux préjudices) et sur la catégorie (degré de certitude). RÉSULTATS : Toutes les personnes co-infectées par le VIH et le VHC devraient subir une évaluation en vue de recevoir un traitement du VHC. Les personnes qui ne sont pas en mesure d’entreprendre un traitement du VHC devraient être soignées pour le VIH afin de ralentir l’évolution de la maladie hépatique. La norme de traitement du VHC de génotype 1 est un régime comprenant de l’interféron pégylé et de la ribavirine dosée en fonction du poids, associés à un inhibiteur de la protéase du VHC. Pour les génotypes 2 ou 3, une bithérapie classique est recommandée pendant 24 semaines s

  9. Soybean Lectin and Related Proteins in Seeds and Roots of Le+ and Le− Soybean Varieties 1

    PubMed Central

    Vodkin, Lila O.; Raikhel, Natasha V.

    1986-01-01

    The localizations of soybean lectin (SBL) and antigenically related proteins in cotyledons and roots of lectin positive (Le+) and lectin negative (Le−) soybean cultivars were compared by light level immunocytochemistry using antibodies produced against the 120 kilodalton (kD) native seed lectin tetramer or its subunits. Lectin is present in the protein bodies of cotyledons cells as are two other seed proteins, the Kunitz trypsin inhibitor and the storage protein glycinin. Analysis of single seed extracts by immunoblotting of sodium dodecyl sulfate-polyacrylamide gels using the same antibodies, reveals up to 4 milligrams of the 30 kD seed lectin protein is present per seed in the Le+ varieties. There is no detectable lectin in the protein bodies of Le− cotyledons as determined by immunocytochemistry and immunoblotting. Enzyme-linked immunosorbent assay confirmed this result to a sensitivity of less than 20 nanograms per seed. In contrast, the roots of both Le+ and Le− plants bind the seed lectin antibody during immunocytochemistry, with fluorescence mainly localized in vacuole-like bodies in the epidermis. Root extracts contain a 33 kD polypeptide that binds anti-SBL antibody at an estimated minimal level of 20 nanograms per 4-day seedling, or 2.0 nanograms per primary root tip. This polypeptide is also present in the embryo axis and in leaves. The latter also contain a 26 kD species that binds seed lectin antibody. The 30 kD seed lectin subunit, however, is not detectable in roots or leaves. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 PMID:16664856

  10. Le lupus systémique juvénile familial: à propos de deux familles

    PubMed Central

    Krich, Sanaa; Inani, Kawtar; Meziane, Mariame; Souilmi, Fatima Zohta; Atmani, Samir; Hida, Mustapha; Harmouch, Taoufik; Amarti, Afaf; Mernissi, Fatima Zohra

    2015-01-01

    Le lupus érythémateux systémique (LES) juvénile est une connectivite rare, d’évolution plus sévère que chez l'adulte. Les cas familiaux sont exceptionnels. Il s'agissait de deux familles (5 patients atteints), chez qui on a objectivé un LES juvénile chez deux sæurs âgées de 14 ans et 6 ans respectivement chez la première famille, deux frères, âgés de 20 ans et 6 ans respectivement plus une sæur âgée de 10 ans chez la deuxième famille. Dans tout les cas le diagnostic de lupus systémique a été posé selon les nouveaux critères du groupe du SLICC (Systemic Lupus International Collaborating Clinics). Tous les patients ont été mis sous photoprotection, dermocorticoïdes et antipaludéens de synthèse sauf dans deux cas où la corticothérapie a été administrée. L’évolution a été favorable après le traitement dans la majorité des cas. Nous rapportons ces cas afin de discuter les particularités épidémiologiques, physiopathologiques, cliniques, paracliniques et thérapeutiques. PMID:26301023

  11. STIL, a peculiar molecule from styles, specifically dephosphorylates the pollen receptor kinase LePRK2 and stimulates pollen tube growth in vitro

    PubMed Central

    2010-01-01

    Background LePRK1 and LePRK2 are two pollen receptor kinases localized to the plasma membrane, where they are present in a high molecular weight complex (LePRK complex). LePRK2 is phosphorylated in mature and germinated pollen, but is dephosphorylated when pollen membranes are incubated with tomato or tobacco style extracts. Results Here we show that LePRK2 dephosphorylation is mediated by a heat-, acid-, base-, DTT- and protease-resistant component from tobacco styles. Using LePRK2 phosphorylation as a tracking assay for purification, style exudates were subjected to chloroform extraction, anionic exchange, and C18 reverse-phase chromatography columns. We finally obtained a single ~3,550 Da compound (as determined by UV-MALDI-TOF MS) that we named STIL (for Style Interactor for LePRKs). STIL increased pollen tube lengths of in vitro germinated pollen in a dose-dependent manner. Conclusion We propose that the LePRK complex perceives STIL, resulting in LePRK2 dephosphorylation and an increase in pollen tube growth. PMID:20175921

  12. Characterization of LeMir, a root-knot nematode-induced gene in tomato with an encoded product secreted from the root.

    PubMed

    Brenner, E D; Lambert, K N; Kaloshian, I; Williamson, V M

    1998-09-01

    A tomato gene that is induced early after infection of tomato (Lycopersicon esculentum Mill.) with root-knot nematodes (Meloidogyne javanica) encodes a protein with 54% amino acid identity to miraculin, a flavorless protein that causes sour substances to be perceived as sweet. This gene was therefore named LeMir (L. esculentum miraculin). Sequence similarity places the encoded protein in the soybean trypsin-inhibitor family (Kunitz). LeMir mRNA is found in root, hypocotyl, and flower tissues, with the highest expression in the root. Rapid induction of expression upon nematode infection is localized to root tips. In situ hybridization shows that LeMir is expressed constitutively in the root-cap and root-tip epidermis. The LeMir protein product (LeMir) was produced in the yeast Pichia pastoris for generation of antibodies. Western-blot analysis showed that LeMir expression is up-regulated by nematode infection and by wounding. LeMir is also expressed in tomato callus tissue. Immunoprint analysis revealed that LeMir is expressed throughout the seedling root, but that levels are highest at the root/shoot junction. Analysis of seedling root exudates revealed that LeMir is secreted from the root into the surrounding environment, suggesting that it may interact with soil-borne microorganisms. PMID:9733543

  13. The tomato ethylene receptors NR and LeETR4 are negative regulators of ethylene response and exhibit functional compensation within a multigene family

    PubMed Central

    Tieman, Denise M.; Taylor, Mark G.; Ciardi, Joseph A.; Klee, Harry J.

    2000-01-01

    The plant hormone ethylene is involved in many developmental processes, including fruit ripening, abscission, senescence, and leaf epinasty. Tomato contains a family of ethylene receptors, designated LeETR1, LeETR2, NR, LeETR4, and LeETR5, with homology to the Arabidopsis ETR1 ethylene receptor. Transgenic plants with reduced LeETR4 gene expression display multiple symptoms of extreme ethylene sensitivity, including severe epinasty, enhanced flower senescence, and accelerated fruit ripening. Therefore, LeETR4 is a negative regulator of ethylene responses. Reduced expression of this single gene affects multiple developmental processes in tomato, whereas in Arabidopsis multiple ethylene receptors must be inactivated to increase ethylene response. Transgenic lines with reduced NR mRNA levels exhibit normal ethylene sensitivity but elevated levels of LeETR4 mRNA, indicating a functional compensation of LeETR4 for reduced NR expression. Overexpression of NR in lines with lowered LeETR4 gene expression eliminates the ethylene-sensitive phenotype, indicating that despite marked differences in structure these ethylene receptors are functionally redundant. PMID:10792050

  14. Natural or controlled experiment? Disentangling anthropogenic and geologic contributions to the sediment load of the Le Sueur River, MN, USA

    NASA Astrophysics Data System (ADS)

    Finnegan, N. J.; Gran, K. B.

    2012-12-01

    Catastrophic draining of glacial Lake Agassiz at the end of the Pleistocene triggered a pulse of incision along the Minnesota River, MN, USA, that is currently propagating into tributary channels and elevating channel incision rates far above regional background levels. At the same time, installation of artificial drainage to remove excess soil water (tiling) in tributaries of the Minnesota has resulted in shorter and higher amplitude hydrographs during spring snow melt and storm events. Thus both natural and anthropogenic explanations exist for high sediment loads from tributaries to the Minnesota River, among them the Le Sueur River, which is currently impaired for turbidity under EPA Clean Water Act standards. Here we investigate the transient incision history of the Le Sueur River to aid in the development of Total Maximum Daily Loads (TMDLs) for sediment in the Le Sueur. Establishing TMDLs for the Le Sueur requires separation of anthropogenic and geologic contributions to current sediment loads. Towards this end, we ran a series of numerical simulations of the excavation of the Le Sueur River valley over the Holocene in order to constrain pre-settlement rates of sediment export. Our approach relies on coupling (with varying strength) a 2D numerical model for river meandering to various 1D numerical models for river incision. Fortuitously, both the initial profile of the Le Sueur (prior to the flood from Lake Agassiz) as well as the timing of the flood itself can be reasonably constrained from LiDAR data and previous Quaternary studies, respectively. Additionally, LiDAR-mapping of discontinuous, unpaired strath terraces combined with OSL and/or 14C dates on 18 strath terrace deposits pin pieces of the long profile of the Le Sueur River in time and space. By minimizing the model misfit for strath terrace ages, the current river elevation long profile, and the width between bluffs along the Le Sueur River valley, we identify a preferred valley excavation history

  15. Une cause rare de dysphagie chez l'enfant: le bézoard

    PubMed Central

    El Boussaadni, Yousra; El Mahjoubi, Sahare; El Ouali, Aziza; Khannoussi, Wafaa; Benajiba, Noufissa

    2014-01-01

    La dysphagie est un signe sémiologique peu fréquent chez l'enfant, dont l'oesophagite est souvent la cause. Les auteurs rapportent une cause rare de dysphagie chez une enfant de 3 ans et demi, ayant évolué 5 mois avant son admission et chez qui l'exploration para clinique a conclu à un bézoard. L'endoscopie a permis une extraction totale. À travers ce cas, nous essayons de rappeler aux praticiens les particularités cliniques de cette affection, ainsi que celles de la prise en charge et le suivi. PMID:25404969

  16. Factors controlling growth and morphology of early Miocene stromatolites from Montaigu-le-Blin, France

    NASA Astrophysics Data System (ADS)

    Bontognali, Tomaso R. R.; Barilaro, Federica; McKenzie, Judith A.; Vasconcelos, Crisogono

    2015-04-01

    A large variety of stromatolite morphotypes are present in the early Miocene sedimentary sequence that outcrops in the region of Montaigu-le-Blin, France. Thanks to its good degree of preservation, this formation is an ideal place to evaluate the key factors controlling the occurrence and morphology of the stromatolites, as well as to study the diagenetic processes that transform a soft, slimy lithifying microbialite into a solid, laminated sedimentary rock. Facies analysis suggests that the Montaigu-le-Blin stromatolites formed in shallow waters, in a restricted, laterally heterogeneous basin. Various evidence suggests a biological origin for the stromatolites, whose formation cannot be explained through abiotic background precipitation driven by evaporation, temperature changes, or migration of metamorphic fluids. Microscopic observations revealed that the Montaigu-le-Blin stromatolites are mainly comprised of authigenic calcite that precipitated directly from the basin waters (no evidence for trapping and binding) in close association with algae, microbial cells, and exopolymeric substances. Well-preserved microfossils of photosynthetic organisms are widespread within the thin sections. The calcite constituting the stromatolites is characterized by positive δ13C values (1.7 to 4.4 o), suggesting that microbial mediation of calcite was mainly related to the metabolic activity of photosynthetic organisms or anoxygenic phototrophs, and not to metabolisms in which organic material is degraded (e.g. sulfate reduction). The laminated habit of the stromatolites results from alternating layers of porous, digit-like sparite and more compacted organic-rich micrite. No correlation was identified, through isotopic analysis, between these two types of laminae and external environmental factors (i.e. temperature, salinity, eutrophication state). Rather, we hypothesize that periodic fluctuations in the dominant microbial/algal species within the mat influenced the morphology

  17. [Examples of textual research on gynecological literature included in Yong le da dian (Yongle's Great Canon)].

    PubMed

    Zhang, Xue-dan; Zhang, Ru-qing

    2010-07-01

    Yongle's Great Canon is a series of books to be read exclusively by the emperors of the Ming Dynasty, so all of the books included are from many rare books collected in Wen Yuan Ge of early Ming Dynasty. These rare books, ranging from Song, Jin, and Yuan Dynasties or from folk sources preserve the original appearance of the ancient books almost without any changes. From a philological viewpoint, the gynecological books included in Yong le da dian are studied, proof-read and checked for its lost texts and different texts. This can serve as a basis for the reprinting and re-publishing of ancient TCM books. PMID:21122346

  18. Le léiomyome vésical : À propos de 5 cas

    PubMed Central

    Saadi, Ahmed; Bouzouita, Abderrazak; Cherif, Mohamed; Ayed, Haroun; Derouiche, Amine; Ben Slama, Riadh Mohamed; Chebil, Mohamed

    2015-01-01

    Résumé Introduction : Les léiomyomes sont des tumeurs mésenchymateuses bénignes. La localisation vésicale de ces tumeurs est rare et représente moins de 0,5 % de toutes les tumeurs vésicales. Le léiomyome vésical est la plus fréquente de ces tumeurs mésenchymateuses et il représente le tiers des lésions bénignes de la vessie. Notre but était d’étudier les particularités épidémiologiques, cliniques, radiologiques, thérapeutiques et évolutives de ce type de tumeur. Matériel et méthodes : Nous rapportons une série de cinq cas de léiomyome vésical, colligés entre 2001 et 2014. Il s’agit de trois femmes et de deux hommes. La symptomatologie clinique est non spécifique et dominée par la cystite. Trois patients ont eu une énucléation et deux ont eu une résection endoscopique de la tumeur. Résultats : Le suivi moyen est de six ans. Un seul patient a présenté une récidive expliquée par la persistance d’un nodule vésical lors de la première intervention, avec une bonne évolution après la deuxième cure chirurgicale. Conclusion : Le léiomyome vésical est une tumeur bénigne et rare. Sa symptomatologie est peu spécifique. Son diagnostic est histologique. Son traitement est toujours chirurgical, offrant un excellent pronostic, sous réserve d’une exérèse complète pour éviter les récidives. PMID:26279718

  19. Maxillary Reconstruction for Sinus Lift Complications With Oro-Antral Fistula: The Le Fort I Approach.

    PubMed

    Pigache, Pénélope; Anavekar, Namrata; Raoul, Gwénaël; Ferri, Joël

    2016-03-01

    Although sinus lift procedures are reliable, some complications can lead to serious maxillary sequelae, including the development of oro-antral fistula (OAF). Maxillary reconstruction in such patients presents a challenge owing to sinus floor alterations, graft remnants, chronic infection, and morbidity from the original sinus lift approach. The current study describes our technique of maxillary reconstruction using a Le Fort 1 approach following major sinus lift complications with associated residual OAF. This technique provides excellent access for sinus curettage, OAF closure, and osseous reconstruction. It allowed a successful rehabilitation in our patients, with no implant loss and good functional and esthetic results. PMID:26825748

  20. Calicophoron daubneyi (Paramphistomidae) in slaughtered cattle in Castilla y León (Spain).

    PubMed

    Ferreras, M Carmen; González-Lanza, Camino; Pérez, Valentín; Fuertes, Miguel; Benavides, Julio; Mezo, Mercedes; González-Warleta, Marta; Giráldez, Javier; Martínez-Ibeas, Ana María; Delgado, Laetitia; Fernández, Miguel; Manga-González, M Yolanda

    2014-01-31

    The prevalence and aetiology of natural paramphistomosis was investigated in cattle slaughtered in the Castilla y León region (Spain) over a 3 year-period. The overall prevalence of positive animals was 6.20%. The parasite burden per animal ranged from 8 to 8005 (median=144) and the ruminal atrium had the highest parasite burden whereas the ruminal dorsal sac the lowest. The prevalence and parasite burden increased with age while these parameters were lower in cattle under intensive management. Calicophoron daubneyi was the only Paramphistomidae species identified using morphoanatomical, histological and molecular methods in the studied animals. PMID:24295956

  1. Apport de l'imagerie dans le diagnostic des sacroiliites infectieuses : à propos de 19 cas

    PubMed Central

    Abid, Hanen; Chaabouni, Salim; Frikha, Faten; Toumi, Nozha; Souissi, Basma; Lahiani, Dorra; Bahloul, Zouhir; Ben Mahfoudh, Khaireddine

    2014-01-01

    Les sacro-iliites infectieuses méritent d’être mieux connues. Leur diagnostic est souvent retardé en raison d'une symptomatologie trompeuse et des diffcultés d'exploration de l'articulation sacro-iliaque. Notre travail est basé sur une étude rétrospective portant sur les cas de SII, recueillis sur une période comprise entre 1997 et 2008 dans notre centre universitaire Sfax-Tunisie. Le diagnostic de sacro-iliite était retenu en présence d'arguments cliniques et radiologiques d'atteinte sacroiliaque. Nous rapportons dix neuf cas de sacroiliites infectieuses (10 hommes et 9 femmes), avec un âge moyen de 32 ans. L'atteinte était unilatérale dans tous les cas. Les radiographies standard faites dans tous les cas ont été suggestives dans 14 cas et normales dans les autres cas. La TDM faite dans 13 cas a montré, un abcès des parties molles dans 8 cas et un séquestre osseux dans 2 cas. L'IRM réalisée dans 8 cas, a objectivé une infiltration des parties molles dans tous les cas et un abcès dans 3 cas. Le germe a été identifié dans 9 cas (3 cas de tuberculose, 3 cas de brucellose, 2 sacro-iliites à pyogène et un cas de candidose). Cette identification était faite par biopsie dans 3 cas, hémocultures dans 2 cas, prélèvement au niveau de la porte d'entrée dans 1 cas et sérodiagnostic dans 3 cas. Pour les autres cas, l'origine pyogène a été retenue sur des arguments cliniques et biologiques. L'imagerie joue un rôle primordial dans le diagnostic précoce et l'orientation étiologique d'une sacroiliite infectieuse. PMID:25120884

  2. Intubation Difficile Chez le Brule de la Face et du Cou a la Phase de Sequelles

    PubMed Central

    Siah, S.; El Wali, A.; Ababou, K.; Nassim Sabah, T.; Drissi, N.K.; Ihrai, I.

    2006-01-01

    Summary L'intubation trachéale chez le brûlé de la face et du cou au stade de séquelles peut être difficile voire impossible chez certains patients. La technique de ventilation à l'aide d'un masque laryngé ou d'intubation avec un fibroscope bronchique permet de résoudre la plupart des problèmes d'intubation difficile. Les Auteurs rapportent deux observations chez deux patientes porteuses de séquelles de brûlures de la face et du cou. PMID:21991028

  3. Critical Dynamics of Burst Instabilities in the Portevin-Le Chatelier Effect

    SciTech Connect

    D'Anna, Gianfranco; Nori, Franco

    2000-11-06

    We investigate the Portevin-Le Chatelier effect (PLC), by compressing Al-Mg alloys in a very large deformation range, and interpret the results from the viewpoint of phase transitions and critical phenomena. The system undergoes two dynamical phase transitions between intermittent (or ''jerky'') and ''laminar'' plastic dynamic phases. Near these two dynamic critical points, the order parameter 1/{tau} of the PLC effect exhibits large fluctuations, and ''critical slowing down'' (i.e., the number {tau} of bursts, or plastic instabilities, per unit time slows down considerably).

  4. Le syndrome de Vogt-Koyanagi Harada dans sa forme purement oculaire: à propos d'un cas

    PubMed Central

    Louaya, Shamil; Bennouk, Youssef; Kriet, Mohamed; Oubaaz, Abdelbarre

    2014-01-01

    Le syndrome de Vogt-Koyanagi-Harada (VKH) est une affection systémique rare, sévère mettant en jeu le pronostic visuel malgré les traitements agressifs, caractérisée par l'association de plusieurs symptômes: oculaires, méningés, auditifs et cutanés secondaire à une auto-immunisation où le mélanocyte serait la cellule cible. Nous rapportons un nouveau cas rare où l'atteinte oculaire est isolée. La sévérité de l'uvéite réside dans la fréquence des récidives, dans la cortico-résistance et dans la forte incidence des complications qui conditionnent le pronostic et expliquent les acuités visuelles finales médiocres. La prise en charge doit être précoce afin d'essayer d'améliorer le pronostic visuel. PMID:25667692

  5. Le syndrome de sevrage nicotinique après chirurgie cardiaque: à propos d’un cas

    PubMed Central

    Kallel, Samy; Ellouze, Maged; Triki, Zied; Karoui, Abdelhamid

    2012-01-01

    L’agitation post-opératoire constitue une pathologie extrêmement fréquente. Les étiologies à évoquer en réanimation sont nombreuses. Le syndrome de sevrage à la nicotine est une cause possible mais rarement évoquée. Nous rapportons le cas d’un patient tabagique qui a été admis en unité de soins intensifs pour un triple pontage aorto-coronaire sous circulation extracorporelle. Les suites opératoires ont été marquées par des difficultés de sédation du patient et puis la survenue d’une agitation au réveil et d’un échec du sevrage de la ventilation mécanique. Après avoir éliminer toutes les causes organiques d’agitation, le syndrome de sevrage à la nicotine a été évoqué et la mise en place d’un timbre de nicotine a permis une amélioration rapide de l’agitation et le sevrage de la ventilation mécanique. Cette observation suggère que le syndrome de sevrage nicotinique peut être responsable d’un véritable delirium et la mise en place d’un timbre transdermique à la nicotine pourrait constituer un moyen diagnostique et thérapeutique simple. PMID:23308317

  6. Update on Development of the Potassium-Argon Laser Experiment (KArLE) Instrument for In Situ Geochronology

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara A.; Li, Z.-H.; Miller, J. S.; Brinckerhoff, W. B.; Clegg, S. M.; Mahaffy, P. R.; Swindle, T. D.; Wiens, R. C.

    2013-01-01

    Absolute dating of planetary samples is an essential tool to establish the chronology of geological events, including crystallization history, magmatic evolution, and alteration. We are addressing this challenge by developing the Potassium (K) -- Argon Laser Experiment (KArLE), building on previous work to develop a K-Ar in situ instrument. KArLE ablates a rock sample, determines the K in the plasma state using laser-induced breakdown spectroscopy (LIBS), measures the liberated Ar using quadrupole mass spectrometry (QMS), and relates the two by the volume of the ablated pit using laser confocal microscopy (LCM). Our goal is for the KArLE instrument to be capable of determining the age of several kinds of planetary samples to address a wide range of geochronolgy problems in planetary science.

  7. L'engelure causée par le butane commercial au cours d’un accident industriel

    PubMed Central

    Assi-Dje Bi Dje, V.; Abhe, C.M.; Sie-Essoh, J.B.; Kouamé, K.; Vilasco, B.

    2014-01-01

    Summary Les engelures sont encore exceptionnelles en Afrique sub-saharienne, mais l’essor des industries pétrochimiques en rapport avec la promotion d’une large utilisation du gaz domestique (butane commercial) expose au risque de survenue de ce type de brûlures abusivement dites gelures. Nous rapportons un cas de brûlures au froid par gaz de pétrole liquéfié (GPL) en milieu professionnel dont le diagnostic de gravité et la prise en charge tardifs ont défavorisé l’évolution locale. Le respect des mesures de sécurité au sein des usines reste néanmoins le principal moyen de prévention de ce type de brûlures méconnues. PMID:26170791

  8. Vital staining of palatal soft tissue in horseshoe Le Fort I osteotomy for superior repositioning of the maxilla.

    PubMed

    Omura, Susumu; Iwai, Toshinori; Honda, Koji; Shibutani, Naoki; Fujita, Koichi; Yamashita, Yosuke; Takasu, Hikaru; Murata, Shogo; Tohnai, Iwai

    2015-05-01

    In maxillary orthognathic surgery, superior repositioning of the maxilla is sometimes difficult, and removal of the bony interference, especially around the descending palatine artery, is very time-consuming in cases of severe maxillary impaction. A useful method introduced for superior repositioning of the maxilla is horseshoe-shaped osteotomy combined with Le Fort I osteotomy (horseshoe Le Fort I osteotomy). However, injury to the palatal soft tissue during horseshoe-shaped osteotomy may cause aseptic complications of the maxilla. Therefore, a safe method is required to prevent such injury to reduce the risk for aseptic necrosis. We describe here vital staining of palatal soft tissue in horseshoe Le Fort I osteotomy for safer superior repositioning of the maxilla. PMID:25887202

  9. Toward a midisuperspace quantization of LeMaitre-Tolman-Bondi collapse models

    SciTech Connect

    Vaz, Cenalo; Witten, Louis; Singh, T. P.

    2001-05-15

    LeMaitre-Tolman-Bondi models of spherical dust collapse have been used and continue to be used extensively to study various stellar collapse scenarios. It is by now well known that these models lead to the formation of black holes and naked singularities from regular initial data. The final outcome of the collapse, particularly in the event of naked singularity formation, depends very heavily on quantum effects during the final stages. These quantum effects cannot generally be treated semiclassically as quantum fluctuations of the gravitational field are expected to dominate before the final state is reached. We present a canonical reduction of LeMaitre-Tolman-Bondi space-times describing the marginally bound collapse of inhomogeneous dust, in which the physical radius R, the proper time of the collapsing dust {tau}, and the mass function F are the canonical coordinates R(r), {tau}(r) and F(r) on the phase space. Dirac's constraint quantization leads to a simple functional (Wheeler-DeWitt) equation. The equation is solved and the solution can be employed to study some of the effects of quantum gravity during gravitational collapse with different initial conditions.

  10. LeFort I segmented osteotomy experience with piezosurgery in orthognathic surgery

    PubMed Central

    Olate, Sergio; Pozzer, Leandro; Unibazo, Alejandro; Huentequeo-Molina, Claudio; Martinez, Felipe; de Moraes, Márcio

    2014-01-01

    The aim of this work was to present the LeFort I segmented osteotomy in consecutive patients using the piezoelectric system. A descriptive study was designed for patients operated on between November 2012 and January 2014. All the patients presented some type of skeletal anomaly and underwent orthognatic surgery via piezoelectric osteotomies. Each maxillary surgery was developed with that system and those patients who also received osteotomies with a reciprocating saw were excluded. Surgical time and complications were analyzed. 19 patients underwent surgery consecutively with an osteotomy average time of 45 minutes. The patients operated on at the beginning were longer surgeries, whereas the final cases were 40 minutes. No type of laceration of vascular elements or laceration of palatal tissue was observed. The protocol was fully implemented, incorporating all the advantages of piezoelectric systems. It is concluded that the LeFort I segmented osteotomy can be performed with low risk of injuring soft tissues and in a time probably less than 50 minutes for the maxillary osteotomy. PMID:25232392

  11. Application of a flush airdata sensing system to a wing leading edge (LE-FADS)

    NASA Technical Reports Server (NTRS)

    Whitmore, Stephen A.; Moes, Timothy R.; Czerniejewski, Mark W.; Nichols, Douglas A.

    1993-01-01

    The feasibility of locating a flush airdata sensing (FADS) system on a wing leading edge where the operation of the avionics or fire control radar system will not be hindered is investigated. The leading-edge FADS system (LE-FADS) was installed on an unswept symmetrical airfoil and a series of low-speed wind-tunnel tests were conducted to evaluate the performance of the system. As a result of the tests it is concluded that the aerodynamic models formulated for use on aircraft nosetips are directly applicable to wing leading edges and that the calibration process is similar. Furthermore, the agreement between the airdata calculations for angle of attack and total pressure from the LE-FADS and known wind-tunnel values suggest that wing-based flush airdata systems can be calibrated to a high degree of accuracy. Static wind-tunnel tests for angles of attack from -50 deg to 50 deg and dynamic pressures from 3.6 to 11.4 lb/sq ft were performed.

  12. Performance of a shaft seal system for the LE-7 rocket engine oxidizer turbopump

    NASA Astrophysics Data System (ADS)

    Oike, Mamoru; Nosaka, Masataka; Kikuchi, Masataka; Watanabe, Yoshiaki

    An experimental study on a rotating-shaft seal system for a high-pressure liquid oxygen (LOX) turbopump has been conducted to develop the LE-7 engine for the Japanese H-II launch vehicle. The LOX turbopump rotating-shaft seal system, which prevents LOX (4.9 MPa) and the high-pressure turbine-drive gas (16.6 MPa, 970 K) from mixing during high-speed operations (18,000 to 20,000 rpm), consists of the following seals: an LOX seal comprising a floating-ring and a wear-ring, a turbine gas seal comprising two floating-rings, and a helium purge seal comprising two segmented circumferential seal-rings. This report describes experimental and observational results concerning the rotating-shaft seal system obtained in the LOX turbopump operations and the seal tests. Based on comparisons between the measurements and the analytical results, sealing characteristics of the seal system are discussed. Inspections of the sealing surfaces after the engine firing tests demonstrated that the LOX turbopump rotating-shaft seal system has sufficient durability for use in the LE-7 engine for the H-II launch vehicle.

  13. Outcome assessment of 603 cases of concomitant inferior turbinectomy and Le Fort I osteotomy

    PubMed Central

    Movahed, Reza; Morales-Ryan, Carlos; Allen, Will R.; Warren, Scott

    2013-01-01

    This retrospective study assessed the outcome of 603 patients undergoing partial inferior turbinectomies (PIT) in association with Lefort I osteotomy. The study included 1234 patients from a single private practice; these patients had dentofacial deformities and underwent Lefort I osteotomy procedures. For the full patient group, 888 patients (72%) were women; in the turbinectomy group, 403 (67%) were women. The anteroposterior, transverse, and vertical dimensions of the mandible, maxilla, and occlusal plane of each subject were assessed, in addition to cephalometric analysis and determination of the presence or absence of temporomandibular joint disorders. PIT, when indicated, was performed after downfracture of the maxilla, providing access to the turbinates where approximately two thirds of the total turbinate volume was removed and septoplasty was completed if indicated. Hypertrophied turbinates causing significant nasal airway obstruction were present in 603 (49%) of the 1234 patients undergoing Le Fort I osteotomy. The results of this study showed that PIT performed simultaneously with Le Fort I osteotomy is a safe method of managing nasal airway obstruction related to hypertrophied turbinates with minimal complications. PMID:24082413

  14. Structure of the nidogen binding LE module of the laminin gamma1 chain in solution.

    PubMed

    Baumgartner, R; Czisch, M; Mayer, U; Pöschl, E; Huber, R; Timpl, R; Holak, T A

    1996-04-01

    The structure of the single LE module between residues 791 and 848 of the laminin gamma1 chain, which contains the high affinity binding site for nidogen, has been probed using NMR methods. The module folds into an autonomous domain which has a stable and unique three-dimensional (3D) structure in solution. The 3D structure was determined on the basis of 362 interproton distance constraints derived from nuclear Overhauser enhancement measurements and 39 phi angles, supplemented by 5 psi and 22 chi1 angles. The main features of the NMR structures are two-stranded antiparallel beta-sheets which are separated by loops and cross-connected by four disulfide bridges. The N-terminal segment which contains the first three disulfide bridges is similar to epidermal growth factor. The C-terminal segment has an S-like backbone profile with a crossover at the last disulfide bridge and comprises two three-residue long beta-strands that form an antiparallel beta-sheet. The LE module possesses an exposed nidogen binding loop that projects away from the main body of the protein. The side-chains of three amino acids which are crucial for binding (Asp, Asn, Val) are all exposed at the domain surface. An inactivating Asn-Ser mutation in this region showed the same 3D structure indicating that these three residues, and possibly an additional Tyr in an adjacent loop, provide direct contacts in the interaction with nidogen. PMID:8648631

  15. Overview and evolution of the LeRC PMAD DC Testbed

    NASA Astrophysics Data System (ADS)

    Soeder, James F.; Frye, Robert J.

    1992-08-01

    Since the beginning of the Space Station Freedom Program (SSFP), the Lewis Research Center (LeRC) has been developed electrical power system test beds to support the overall design effort. Through this time, the SSFP has changed the design baseline numerous times, however, the test bed effort has endeavored to track these changes. Beginning in August 1989 with the baseline and an all DC system, a test bed was developed to support the design baseline. The LeRC power measurement and distribution (PMAD) DC test bed and the changes in the restructure are described. The changes includeed the size reduction of primary power channel and various power processing elements. A substantial reduction was also made in the amount of flight software with the subsequent migration of these functions to ground control centers. The impact of these changes on the design of the power hardware, the controller algorithms, the control software, and a description of their current status is presented. An overview of the testing using the test bed is described, which includes investigation of stability and source impedance, primary and secondary fault protection, and performance of a rotary utility transfer device. Finally, information is presented on the evolution of the test bed to support the verification and operational phases of the SSFP in light of these restructure scrubs.

  16. Overview and evolution of the LeRC PMAD DC test bed

    NASA Astrophysics Data System (ADS)

    Soeder, James F.; Frye, Robert J.

    Since the beginning of the Space Station Freedom Program (SSFP), the Lewis Research Center (LeRC) has been developed electrical power system test beds to support the overall design effort. Through this time, the SSFP has changed the design baseline numerous times, however, the test bed effort has endeavored to track these changes. Beginning in August 1989 with the baseline and an all DC system, a test bed was developed to support the design baseline. The LeRC power measurement and distribution (PMAD) DC test bed and the changes in the restructure are described. The changes included the size reduction of primary power channel and various power processing elements. A substantial reduction was also made in the amount of flight software with the subsequent migration of these functions to ground control centers. The impact of these changes on the design of the power hardware, the controller algorithms, the control software, and a description of their current status is presented. An overview of the testing using the test bed is described, which includes investigation of stability and source impedance, primary and secondary fault protection, and performance of a rotary utility transfer device. Finally, information is presented on the evolution of the test bed to support the verification and operational phases of the SSFP in light of these restructure scrubs.

  17. Enjeux technologiques du LHC, le grand collisionneur de particules supraconducteur en projet au CERN

    NASA Astrophysics Data System (ADS)

    Lebrun, Ph.

    1991-02-01

    The LHC large superconducting particle collider project is presented, with particular emphasis on its major technological requirements and returns, mostly in the domains of high-field electromagnets, superfluid helium cryogenics, and integration of such advanced techniques in a large machine. The corresponding cooperation and technological transfer to European laboratories and industries and briefly discussed. Le projet de collisionneur de particules supraconducteur LHC est présenté, en mettant l'accent sur ses enjeux technologiques majeurs, principalement dans le domaine des électro-aimants à champs intenses, de la cryogénie à l'hélium superfluide et de l'intégration de ces techniques de pointe dans une grande machine. Les actions de coopération et les mécanismes de transfert technologique, en cours ou à créer, vers les laboratoires et les industries européens sont brièvement évoqués.

  18. LeCTR2, a CTR1-like protein kinase from tomato, plays a role in ethylene signalling, development and defence.

    PubMed

    Lin, Zhefeng; Alexander, Lucy; Hackett, Rachel; Grierson, Don

    2008-06-01

    Arabidopsis AtCTR1 is a Raf-like protein kinase that interacts with ETR1 and ERS and negatively regulates ethylene responses. In tomato, several CTR1-like proteins could perform this role. We have characterized LeCTR2, which has similarity to AtCTR1 and also to EDR1, a CTR1-like Arabidopsis protein involved in defence and stress responses. Protein-protein interactions between LeCTR2 and six tomato ethylene receptors indicated that LeCTR2 interacts preferentially with the subfamily I ETR1-type ethylene receptors LeETR1 and LeETR2, but not the NR receptor or the subfamily II receptors LeETR4, LeETR5 and LeETR6. The C-terminus of LeCTR2 possesses serine/threonine kinase activity and is capable of auto-phosphorylation and phosphorylation of myelin basic protein in vitro. Overexpression of the LeCTR2 N-terminus in tomato resulted in altered growth habit, including reduced stature, loss of apical dominance, highly branched inflorescences and fruit trusses, indeterminate shoots in place of determinate flowers, and prolific adventitious shoot development from the rachis or rachillae of the leaves. Expression of the ethylene-responsive genes E4 and chitinase B was upregulated in transgenic plants, but ethylene production and the level of mRNA for the ethylene biosynthetic gene ACO1 was unaffected. The leaves and fruit of transgenic plants also displayed enhanced susceptibility to infection by the fungal pathogen Botrytis cinerea, which was associated with much stronger induction of pathogenesis-related genes such as PR1b1 and chitinase B compared with the wild-type. The results suggest that LeCTR2 plays a role in ethylene signalling, development and defence, probably through its interactions with the ETR1-type ethylene receptors of subfamily I. PMID:18346193

  19. Le Pseudomonas: Experience du Centre des Brules D’Annaba et Revue de la Litterature

    PubMed Central

    Chaibdraa, A.; Medjellekh, M.S.; Saouli, A.; Bentakouk, M.C.

    2008-01-01

    Summary Le Pseudomonasest un agent pathogène à l'origine d'infections nosocomiales graves dans les centres des brûlés. Son opportunisme et sa virulence en font une préoccupation majeure. Ce travail se propose d'évaluer la place de cette bactérie dans l'écologie bactérienne locale et d'en apprécier la sensibilité aux antibiotiques. Cette étude rétrospective préliminaire porte sur la période de juin 2003 à décembre 2005. Elle intéresse l'ensemble des prélèvements bactériologiques ayant pu être réalisés au centre des brûlés d'Annaba. L'effectif est de 633 micro-organismes isolés dont 128 Pseudomonas (20,2%): 127 aeruginosa (99,2%), 1 fluorescens (0,8%); distribution selon le site de prélèvement: écouvillon (87,5%), prélèvement trachéobronchique (4,6%), hémoculture (3,1%), cathéters (1,6%), urine (1,6%) et sonde urinaire (1,6%). Le pyocyanique se situe après le staphylocoque pour les prélèvements précoces et repasse en tête après un séjour supérieur à une semaine, où 89% des pyocyaniques sont identifiés. Il est en première position dans les pneumopathies sous ventilation assistée invasive. Il se classe troisième dans les hémocultures et les cultures de cathéters. Dans les infections urinaires il est devancé par Candida et la flore périnéale. Les 128 antibiogrammes regroupent 314 réponses sensibles. La sensibilité à plus de deux antibiotiques est de 68%, à deux antibiotiques 24% et à un antibiotique 8%. Seules quatre molécules restent actives: ciprofloxacine > péfloxacine > pipéracilline > ceftazidime. Une résistance absolue est retrouvée pour trois Pseudomonas (2,4%). Le pronostic sévère des infections nosocomiales à pyocyanique et les risques d'options thérapeutiques très limitées font toute leur gravité, d'où l'intérêt de respecter des règles strictes de prescription des antibiotiques et des mesures de prévention. PMID:21991140

  20. Volume Measurements of Laser-generated Pits for in Situ Geochronology Using KArLE (Potassium-Argon Laser Experiment)

    NASA Technical Reports Server (NTRS)

    French, R. A.; Cohen, B. A.; Miller, J. S.

    2014-01-01

    KArLE (Potassium-­-Argon Laser Experiment) has been developed for in situ planetary geochronology using the K - Ar (potassium-­-argon) isotope system, where material ablated by LIBS (Laser-­-Induced Breakdown Spectroscopy) is used to calculate isotope abundances. We are determining the accuracy and precision of volume measurements of these pits using stereo and laser microscope data to better understand the ablation process for isotope abundance calculations. If a characteristic volume can be determined with sufficient accuracy and precision for specific rock types, KArLE will prove to be a useful instrument for future planetary rover missions.

  1. Analyse de L'ancrage des Vortex Intergrains pour le Yttrium BARYUM(2) CUIVRE(3) OXYGENE(7) Polycristallin

    NASA Astrophysics Data System (ADS)

    Fournier, Patrick

    Le Modele de l'Etat Critique Generalise (MECG) est utilise pour decrire les proprietes magnetiques et de transport du YBa_2Cu_3O _7 polycristallin. Ce modele empirique permet de relier la densite de courant critique a la densite de lignes de flux penetrant dans la region intergrain. Deux techniques de mesures sont utilisees pour caracteriser nos materiaux. La premiere consiste a mesurer le champ au centre d'un cylindre creux en fonction du champ magnetique applique pour des temperatures comprises entre 20 et 85K. En variant l'epaisseur de la paroi du cylindre creux, il est possible de suivre l'evolution des cycles d'hysteresis et de determiner des champs caracteristiques qui varient en fonction de cette dimension. En utilisant un lissage des resultats experimentaux, nous determinons J _{co}, H_ {o} et n, les parametres du MECG. La forme des cylindres, avec une longueur comparable au diametre externe, entrai ne la presence d'un champ demagnetisant qui peut etre inclus dans le modele theorique. Ceci nous permet d'evaluer la fraction du volume ecrante, f _{g}, ainsi que le facteur demagnetisant N. Nous trouvons que J_{ co}, H_{o} et f_{g} dependent de la temperature, tandis que n et N (pour une epaisseur de paroi fixe) n'en dependent pas. La deuxieme technique consiste a mesurer le courant critique de lames minces en fonction du champ applique pour differentes temperatures. Nous utilisons un montage que nous avons developpe permettant d'effectuer ces mesures en contact direct avec le liquide refrigerant, i.e. dans l'azote liquide. Nous varions la temperature du liquide en variant la pression du gaz au-dessus du bain d'azote. Cette methode nous permet de balayer des temperatures entre 65K et la temperature critique du materiau ({~ }92K). Nous effectuons le lissage des courbes de courant critique en fonction du champ applique encore a l'aide du MECG, pour a nouveau obtenir ses parametres. Pour trois echantillons avec des traitements thermiques differents, les parametres

  2. Dermatomyosite du sujet âgé: étude de 4 observations dans le sud tunisien

    PubMed Central

    Frikha, Faten; Snoussi, Mouna; Salah, Raida Ben; Saidi, Noura; Kaddour, Neila; Bahloul, Zouhir

    2012-01-01

    La dermatomyosite (DM) touche essentiellement l’adolescent et l’adulte jeune, elle est très rare chez le sujet âgé, le plus souvent associée à des complications iatrogènes et à une pathologie cancéreuse. Nous avons étudié les caractéristiques de la DM du sujet âgé à travers une étude rétrospective dans laquelle nous avons comparé 4 patients âgés de plus de 65 ans au début de la myosite avec 40 sujets jeunes. PMID:23308331

  3. The LeFE algorithm: embracing the complexity of gene expression in the interpretation of microarray data.

    PubMed

    Eichler, Gabriel S; Reimers, Mark; Kane, David; Weinstein, John N

    2007-01-01

    Interpretation of microarray data remains a challenge, and most methods fail to consider the complex, nonlinear regulation of gene expression. To address that limitation, we introduce Learner of Functional Enrichment (LeFE), a statistical/machine learning algorithm based on Random Forest, and demonstrate it on several diverse datasets: smoker/never smoker, breast cancer classification, and cancer drug sensitivity. We also compare it with previously published algorithms, including Gene Set Enrichment Analysis. LeFE regularly identifies statistically significant functional themes consistent with known biology. PMID:17845722

  4. Pour Une Poesie Chretienne a L'age Baroque: Mysticisme, Heroisme et Feminisme Chez Pierre Le Moyne 1602-1671

    ERIC Educational Resources Information Center

    Fares, Laila

    2012-01-01

    The study constituting the object of this research on one of the best French poets of the 17th century, yet one of the least known, Pierre Le Moyne, aims at restoring this great French poet in his right place, preparing and clearing the way in order to allow further research and stimulate future interest in his works. Pierre Le Moyne is not only…

  5. Modelisation numerique et validation experimentale d'un systeme de protection contre le givre par elements piezoelectriques

    NASA Astrophysics Data System (ADS)

    Harvey, Derek

    Le degivrage au moyen d'actuateurs piezoelectriques est considere comme une avenue prometteuse pour le developpement de systemes a faible consommation d'energie applicables aux helicopteres legers. Ce type de systeme excite des frequences de resonances d'une structure pour produire des deformations suffisantes pour rompre l'adherence de la glace. Par contre, la conception de tel systeme demeure generalement mal comprise. Ce projet de maitrise etudie l'utilisation de methodes numeriques pour assister la conception des systemes de protection contre le givre a base d'elements piezoelectriques. La methodologie retenue pour ce projet a ete de modeliser differentes structures simples et de simuler l'excitation harmonique des frequences de resonance au moyen d'actuateurs piezoelectriques. Le calcul des frequences de resonances ainsi que la simulation de leur excitation a ensuite ete validee a l'aide de montages experimentaux. La procedure a ete realisee pour une poutre en porte-a-faux et pour une plaque plane a l'aide du logiciel de calcul par elements finis, Abaqus. De plus, le modele de la plaque plane a ete utilise afin de realiser une etude parametrique portant sur le positionnement des actuateurs, l'effet de la rigidite ainsi que de l'epaisseur de la plaque. Finalement, la plaque plane a ete degivree en chambre climatique. Des cas de degivrage ont ete simules numeriquement afin d'etudier la possibilite d'utiliser un critere base sur la deformation pour predire le succes du systeme. La validation experimentale a confirme la capacite du logiciel a calculer precisement a la fois les frequences et les modes de resonance d'une structure et a simuler leur excitation par des actuateurs piezoelectriques. L'etude revele que la definition de l'amortissement dans le modele numerique est essentiel pour l'obtention de resultats precis. Les resultats de l'etude parametrique ont demontre l'importance de minimiser l'epaisseur et la rigidite afin de reduire la valeur des frequences

  6. Water-resources reconnaissance of Île de la Gonâve, Haiti

    NASA Astrophysics Data System (ADS)

    Troester, Joseph W.; Turvey, Michael D.

    Île de la Gonâve is a 750-km2 island off the coast of Haiti. The depth to the water table ranges from less than 30 m in the Eocene and Upper Miocene limestones to over 60 m in the 300-m-thick Quaternary limestone. Annual precipitation ranges from 800-1,400 mm. Most precipitation is lost through evapotranspiration and there is virtually no surface water. Roughly estimated from chloride mass balance, about 4% of the precipitation recharges the karst aquifer. Cave pools and springs are a common source for water. Hand-dug wells provide water in coastal areas. Few productive wells have been drilled deeper than 60 m. Reconnaissance field analyses indicate that groundwater in the interior is a calcium-bicarbonate type, whereas water at the coast is a sodium-chloride type that exceeds World Health Organization recommended values for sodium and chloride. Tests for the presence of hydrogen sulfide-producing bacteria were negative in most drilled wells, but positive in cave pools, hand-dug wells, and most springs, indicating bacterial contamination of most water sources. Because of the difficulties in obtaining freshwater, the 110,000 inhabitants use an average of only 7 L per person per day. L'Île de la Gonâve est une île de 750 km2 au large de la côte d'Haïti. La profondeur de la nappe varie entre moins de 30 m dans les calcaires de l'Éocène et du Miocène supérieur à plus de 60 m dans les calcaires quaternaires épais de 300 m. Les précipitations annuelles sont comprises entre 800-1.400 mm. La plus grande partie des précipitations est perdue par évapotranspiration et il n'y a pratiquement pas d'eau de surface. Le bilan de masse des chlorures permet d'estimer à 4% des précipitations le montant de la recharge de l'aquifère karstique. Des bassins dans les grottes et des sources sont la source d'eau courante. Des puits creusés à la main fournissent de l'eau dans les zones côtières. Quelques puits productifs ont été forés dépassant 60 m de profondeur. L

  7. Water-resources reconnaissance of Île de la Gonâve, Haiti

    NASA Astrophysics Data System (ADS)

    Troester, Joseph W.; Turvey, Michael D.

    Île de la Gonâve is a 750-km2 island off the coast of Haiti. The depth to the water table ranges from less than 30 m in the Eocene and Upper Miocene limestones to over 60 m in the 300-m-thick Quaternary limestone. Annual precipitation ranges from 800-1,400 mm. Most precipitation is lost through evapotranspiration and there is virtually no surface water. Roughly estimated from chloride mass balance, about 4% of the precipitation recharges the karst aquifer. Cave pools and springs are a common source for water. Hand-dug wells provide water in coastal areas. Few productive wells have been drilled deeper than 60 m. Reconnaissance field analyses indicate that groundwater in the interior is a calcium-bicarbonate type, whereas water at the coast is a sodium-chloride type that exceeds World Health Organization recommended values for sodium and chloride. Tests for the presence of hydrogen sulfide-producing bacteria were negative in most drilled wells, but positive in cave pools, hand-dug wells, and most springs, indicating bacterial contamination of most water sources. Because of the difficulties in obtaining freshwater, the 110,000 inhabitants use an average of only 7 L per person per day. L'Île de la Gonâve est une île de 750 km2 au large de la côte d'Haïti. La profondeur de la nappe varie entre moins de 30 m dans les calcaires de l'Éocène et du Miocène supérieur à plus de 60 m dans les calcaires quaternaires épais de 300 m. Les précipitations annuelles sont comprises entre 800-1.400 mm. La plus grande partie des précipitations est perdue par évapotranspiration et il n'y a pratiquement pas d'eau de surface. Le bilan de masse des chlorures permet d'estimer à 4% des précipitations le montant de la recharge de l'aquifère karstique. Des bassins dans les grottes et des sources sont la source d'eau courante. Des puits creusés à la main fournissent de l'eau dans les zones côtières. Quelques puits productifs ont été forés dépassant 60 m de profondeur. L

  8. Integrated Meteorological Observation Network in Castile-León (Spain)

    NASA Astrophysics Data System (ADS)

    Merino, A.; Guerrero-Higueras, A. M.; Ortiz de Galisteo, J. P.; López, L.; García-Ortega, E.; Nafría, D. A.; Sánchez, J. L.

    2012-04-01

    In the region of Castile-Leon, in the northwest of Spain, the study of weather risks is extremely complex because of the topography, the large land area of the region and the variety of climatic features involved. Therefore, as far as the calibration and validation of the necessary tools for the identification and nowcasting of these risks are concerned, one of the most important difficulties is the lack of observed data. The same problem arises, for example, in the analysis of particularly relevant case studies. It was hence deemed necessary to create an INTEGRATED METEOROLOGICAL OBSERVATION NETWORK FOR CASTILE-LEON. The aim of this network is to integrate within one single platform all the ground truth data available. These data enable us to detect a number of weather risks in real time. The various data sources should include the networks from the weather stations run by different public institutions - national and regional ones (AEMET, Junta de Castilla y León, Universities, etc.) -, as well as the stations run by voluntary observers. The platform will contain real or cuasi-real time data from the ground weather stations, but it will also have applications to enable voluntary observers to indicate the presence or absence of certain meteors (snow, hail) or even provide detailed information about them (hailstone size, graupel, etc.). The data managed by this network have a high scientific potential, as they may be used for a number of different purposes: calibration and validation of remote sensing tools, assimilation of observation data from numerical models, study of extreme weather events, etc. An additional aim of the network is the drawing of maps of weather risks in real time. These maps are of great importance for the people involved in risk management in each region, as well as for the general public. Finally, one of the first applications developed has been the creation of observation maps in real time. These applications have been constructed using NCL

  9. Recommandations pour le dépistage de l’hypertension chez les adultes canadiens

    PubMed Central

    Lindsay, Patrice; Gorber, Sarah Connor; Joffres, Michel; Birtwhistle, Richard; McKay, Donald; Cloutier, Lyne

    2013-01-01

    Résumé Objectif Présenter des recommandations concernant le dépistage de l’hypertension chez les adultes de 18 ans et plus qui n’ont pas reçu antérieurement de diagnostic d’hypertension. Qualité des données Les données probantes sont tirées d’une recension systématique dans MEDLINE, EMBASE et la base de données des synthèses systématiques de la Collaboration Cochrane (EBM Reviews), de janvier 1985 à septembre 2011. Les types d’études retenues se limitaient aux études randomisées contrôlées, aux synthèses systématiques et aux études observationnelles avec groupes témoins. Message principal Trois fortes recommandations se sont dégagées de données probantes de qualité modérée. Il est recommandé de mesurer la pression artérielle à toutes les consultations appropriées en soins primaires, conformément aux techniques actuelles décrites dans les recommandations du Programme éducatif canadien sur l’hypertension pour la mesure de la pression artérielle en cabinet et en soins ambulatoires. Les critères du Programme éducatif canadien sur l’hypertension pour l’évaluation et le diagnostic de l’hypertension devraient s’appliquer aux personnes chez qui on observe une pression artérielle élevée. Conclusion À la suite d’un examen des plus récentes données probantes, le Groupe d’étude canadien sur les soins de santé préventifs continue de recommander la mesure de la pression artérielle lors des consultations périodiques auprès du médecin.

  10. Le Fort III external midface distraction: surgical outcomes and skeletal stability.

    PubMed

    Iannetti, Giorgio; Ramieri, Valerio; Pagnoni, Mario; Fadda, Maria Teresa; Cascone, Piero

    2012-05-01

    A retrospective study on the stability of Le Fort III midface advancement with distraction in craniofacial dysostosis. Twenty-six surgical procedures for midface advancement were performed between 2000 and 2009. Subjects were 14 consecutive patients who underwent Le Fort III osteotomy with midface advancement using a rigid external distraction device (Synthes) in the Dep of Maxillo-Facial Surgery of the University "Sapienza" of Rome. In this study, 8 patients (n = 3 females, n = 5 males) affected by craniofacial dysostosis (Crouzon, n = 5; Apert, n = 3; Pfeiffer syndrome, n = 1; and other, n = 1) were selected on the basis of age and radiologic documentation. The mean age at the time of the procedure was 8.6 years, and all the patients had at least 1 year of follow-up after distraction.The radiologic documentation of each case was composed of posteroanterior and lateral cephalograms preoperatively (T1), at the time of removal of the distractor device (T2), and at follow-up (T3).The average latency period before activation of the distractor was 5 days. The device was activated on an average of 15 mm (range, 7-22 mm) as recorded on the device at a rate of 1 mm/d. Activation period ranged from 7 to 15 days, and the consolidation period was 8 to 12 weeks.Seven anatomic landmarks and 5 cephalometric measurements were identified on the lateral cephalograms at each of the 3 time periods. The cephalograms underwent digital analysis via Dolphin imaging digitalization software by 2 operators independently. The displacement of each identified landmark was recorded and examined in relation to their position at each time point.Cephalometric analysis revealed stability of Le Fort III midface advancement during follow-up. However, bone growth after midface advancement is limited, and as reported in the literature, almost no spontaneous growth is present because of the intrinsic nature of malformations. Patients treated in the growing age benefit from midface advancement, with

  11. Histoire d’un itinéraire épidémiologique entre le Burkina Faso et la Côte d’Ivoire : le cas des foyers de maladie du sommeil de Koudougou

    PubMed Central

    Kiendrébéogo, D.; Kambiré, R.; Jamonneau, V.; Lingué, K.; Solano, P.; Courtin, F.

    2012-01-01

    Dans la première moitié du XXème siècle, alors que la Haute-Volta (actuel Burkina Faso) subissait une terrible épidémie de maladie du sommeil, l’administration coloniale française a orchestré des déplacements massifs de populations de la Haute-Volta vers la Côte d’Ivoire, pour exploiter le territoire. Cela a conduit à la mise en place de villages de colonisation Mossi en zone forestière ivoirienne, comme ceux de Koudougou, issus de l’une des régions les plus peuplées de Haute-Volta, mais aussi l’une des plus touchées par la maladie du sommeil. Depuis 2000, au Burkina Faso, c’est dans le district sanitaire de Koudougou que sont dépistés passivement le plus grand nombre de trypanosomés en provenance de Côte d’Ivoire. Qui sont-ils ? Où habitent-ils au Burkina Faso ? D’où viennent-ils de Côte d’Ivoire ? Après avoir retracé l’histoire épidémiologique des villages de Koudougou au Burkina Faso et en Côte d’Ivoire, nous avons recherché les trypanosomés dépistés passivement depuis 2000 dans le district sanitaire de Koudougou au Burkina Faso. Au total, dix trypanosomés ont été enquêtés. Le processus de propagation de la maladie du sommeil dans l’espace ivoiro-burkinabé a été mis en évidence et des zones à risque de la maladie identifiées dans ce même espace. PMID:23193525

  12. Deep inelastic structure functions from electron scattering on hydrogen, deuterium, and iron at 0. 6 GeV sup 2 le Q sup 2 le 30. 0 GeV sup 2

    SciTech Connect

    Whitlow, L.W.

    1990-03-01

    We report the final results from experiment E140, a recent deep inelastic electron-deuterium and electron-iron scattering experiment at SLAC. In addition, we present the results of a combined global analysis of all SLAC deep inelastic electron-hydrogen and electron-deuterium cross section measurements between 1970 and 1983. Data from seven earlier experiments are re-radiatively corrected and normalized to experiment E140. We report extractions of R(x,Q{sup 2}) and F{sub 2}(x,Q{sup 2}) for hydrogen and deuterium over the entire SLAC kinematic range: .06{le} x {le}.90 and 0.6{le} Q{sup 2} {le}30.0 (GeV{sup 2}). We fine that R{sup p} = R{sup d}, as expected by QCD. Extracted values of R(x,Q{sup 2}) are significantly larger than predictions based on QCD and on QCD with the inclusion of kinematic target mass terms. This difference indicates that dynamical higher twist effects may be important in the SLAC kinematic range. A best fit empirical model of R(x,Q{sup 2}) is used to extract F{sub 2} from each cross section measurement. These F{sub 2} extractions are compared with F{sub 2} data from EMC and BCDMS. Agreement is observed with EMC when the EMC data are multiplied by 1.07. Agreement is observed with BCDMS over a limited range in x. The ratios of F{sub 2}{sup d}/F{sub 2}{sup p} are examined for Q{sup 2} dependence. We observe a significant negative slope for x {le} .6, and a significant positive slope above x > .7, in excellent agreement with predictions based on QCD with the inclusion of kinematic target mass terms. 111 refs., 40 figs., 34 tabs.

  13. 78 FR 13665 - L.E. Bell Construction Company, Inc.; Notice of Termination of Exemption by Implied Surrender and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... of exemption by implied surrender. b. Project No.: 8233-001. c. Date Initiated: February 21, 2013. d. Exemptee: L.E. Bell Construction Company, Inc. e. Name and Location of Project: The Tallapoosa River Hydroelectric Project is located on the Tallapoosa River in Cleburne County, Alabama. f. Filed Pursuant to:...

  14. Three-dimensional computed tomographic evaluation of Le Fort III distraction osteogenesis with an external device in syndromic craniosynostosis.

    PubMed

    Wery, M F; Nada, R M; van der Meulen, J J; Wolvius, E B; Ongkosuwito, E M

    2015-03-01

    There is little anteroposterior growth of the midface in patients with syndromic craniosynostosis who are followed up over time without intervention. A Le Fort III with distraction osteogenesis can be done to correct this. This is a controlled way in which to achieve appreciable stable advancement of the midface without the need for bone grafting, but the vector of the movement is not always predictable. The purpose of this study was to evaluate the 3-dimensional effect of Le Fort III distraction osteogenesis with an external frame. Ten patients (aged 7-19 years) who had the procedure were included in the study. The le Fort III procedure and the placement of the external frame were followed by an activation period and then a 3-month retention period. Computed tomographic (CT) images taken before and after operation were converted and loaded into 3-dimensional image rendering software and compared with the aid of a paired sample t test and a colour-coded qualitative analysis. Comparison of the CT data before and after distraction indicated that the amount of midface advancement was significant. Le Fort III distraction osteogenesis is an effective way to advance the midface. However, the movement during osteogenesis is not always exactly in the intended direction, and a secondary operation is often necessary. Three-dimensional evaluation over a longer period of time is necessary. PMID:25605236

  15. Effects of Le Fort I Osteotomy on Maxillary Anterior Teeth: A 5-Year Follow Up of 42 Cases

    PubMed Central

    Mesgarzadeh, Abolhasan; Motamedi, Mohammad Hosein Kalantar; Akhavan, Hengameh; Tousi, Tara Sarvghad; Mehrvarzfar, Peyman; Eshkevari, Pooyan Sadr

    2010-01-01

    Aim: The aim of this study was to assess the vitality of maxillary anterior teeth following Le Fort I osteotomy. Materials and Methods: A total of 245 maxillary anterior teeth in 42 patients were examined by several pulp vitality tests before surgery and 1 to 5 years postoperatively. Data were recorded in SPSS and were statistically analyzed by using Pearson, χ2, and Fisher exact tests. Results: This study showed a significant number (91%) of the maxillary anterior teeth to be sensitive to cold, 88.8% to electrical pulp test, and 89.4% to heat tests 12 months to 5 years following Le Fort I osteotomy. A total of 8 teeth (3.2%) had undergone root canal therapy (RCT) because they were nonvital and had developed apical lesions. Pain on percussion was observed in 5.7% of the teeth. External resorption was significantly associated with insensitivity (P < .05). Orthodontic therapy adds to this especially if excessive force is applied. Conclusion: A significant number of teeth had sensitivity after Le Fort I osteotomy. Only 3.2% needed RCT. When all vitality tests were negative, we used periapical radiolucency as the main criterion for judging pulp necrosis requiring RCT. It should be stressed that the outcomes of a single test cannot be considered as a reliable indicator for the presence or absence of pulpal or periapical disease or for RCT. Although the complications following Le Fort I osteotomy are few, follow-up is mandatory. PMID:20090842

  16. [Valutare le esperienze positive e negative: la validazione di una nuova misura del benessere in una popolazione italiana].

    PubMed

    Corno, Giulia; Molinari, Guadalupe; Baños, Rosa Maria

    2016-01-01

    RIASSUNTO. Lo scopo del presente studio è quello di esplorare le proprietà psicometriche di uno strumento di misurazione dell'affetto, la Scala di Esperienze Positive e Negative (SPANE), all'interno di una popolazione italiana. Gli esiti dell'analisi fattoriale confermativa comprovano l'attesa struttura a due fattori, sentimenti positivi e negativi. Le correlazioni con altre dimensioni (per es., ansia, depressione, affetto, aspettative future) confermano i risultati ottenuti con le precedenti versioni della scala: affetto negativo, ansia, depressione e aspettative future negative correlano positivamente con la subscala di esperienze negative e negativamente con la subscala di esperienze positive dello SPANE. In conclusione, i risultati del nostro studio dimostrano che la versione italiana dello SPANE presenta caratteristiche psicometriche simili a quelle mostrate dalla versione orginale e da successive validazioni dello strumento in altre lingue. La scala presenta, inoltre, affidabilità e validità fattoriale. Lo SPANE è un indice utile dal punto di vista clinico che può fornire informazioni rilevanti circa l'esperienza emotiva e il benessere della persona. Nonostante ulteriori studi siano necessari per confermare le caratteristiche psicometriche della scala, la presente validazione della versione italiana dello SPANE può contribuire ad ampliare la ricerca nell'ambito del benessere in una popolazione Italiana. PMID:27362822

  17. 78 FR 72745 - Bureau of Political-Military Affairs; Administrative Debarment of LeAnne Lesmeister Under the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ... of Political-Military Affairs; Administrative Debarment of LeAnne Lesmeister Under the Arms Export... CONTACT: Sue Gainor, Director, Office of Defense Trade Controls Compliance, Bureau of Political-Military... services. Section 127.7(a) of the ITAR authorizes the Assistant Secretary of State for...

  18. Un cas de leishmaniose féline disséminée dans le sud de la France

    PubMed Central

    Pocholle, E.; Reyes-Gomez, E.; Giacomo, A.; Delaunay, P.; Hasseine, L.; Marty, P.

    2012-01-01

    Cet article rapporte un cas de leishmaniose féline disséminée chez un chat (Felis catus) de 14 ans, séropositif pour le FIV et vivant dans les Alpes-Maritimes (sud de la France). Le chat présente des papules érythémateuses ulcérées sur la face et l’encolure, et une lésion proliférative ulcérée sur l’oreille gauche. C’est l’examen histopathologique des lésions cutanées qui permet le diagnostic d’une leishmaniose disséminée, associée à un carcinome épidermoïde de l’oreille. 100 mg d’allopurinol administrés une fois par jour per os pendant quatre mois ont permis la rémission totale des lésions cutanées. Des prélèvements post mortem ont révélé la persistance du parasite dans l’organisme après six mois de traitement. Cet article discute de la sensibilité du chat à la leishmaniose et de son rôle potentiel de réservoir. PMID:22314243

  19. Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis.

    PubMed

    Sallam, Tamer; Jones, Marius C; Gilliland, Thomas; Zhang, Li; Wu, Xiaohui; Eskin, Ascia; Sandhu, Jaspreet; Casero, David; Vallim, Thomas Q de Aguiar; Hong, Cynthia; Katz, Melanie; Lee, Richard; Whitelegge, Julian; Tontonoz, Peter

    2016-06-01

    Liver X receptors (LXRs) are transcriptional regulators of cellular and systemic cholesterol homeostasis. Under conditions of excess cholesterol, LXR activation induces the expression of several genes involved in cholesterol efflux, facilitates cholesterol esterification by promoting fatty acid synthesis, and inhibits cholesterol uptake by the low-density lipoprotein receptor. The fact that sterol content is maintained in a narrow range in most cell types and in the organism as a whole suggests that extensive crosstalk between regulatory pathways must exist. However, the molecular mechanisms that integrate LXRs with other lipid metabolic pathways are incompletely understood. Here we show that ligand activation of LXRs in mouse liver not only promotes cholesterol efflux, but also simultaneously inhibits cholesterol biosynthesis. We further identify the long non-coding RNA LeXis as a mediator of this effect. Hepatic LeXis expression is robustly induced in response to a Western diet (high in fat and cholesterol) or to pharmacological LXR activation. Raising or lowering LeXis levels in the liver affects the expression of genes involved in cholesterol biosynthesis and alters the cholesterol levels in the liver and plasma. LeXis interacts with and affects the DNA interactions of RALY, a heterogeneous ribonucleoprotein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the mouse liver. These findings outline a regulatory role for a non-coding RNA in lipid metabolism and advance our understanding of the mechanisms that coordinate sterol homeostasis. PMID:27251289

  20. In Situ Geochronology on the Mars 2020 Rover with KArLE (Potassium-Argon Laser Experiment)

    NASA Technical Reports Server (NTRS)

    Cohen, B. A.; Swindle, T. D.; Roark, S. E.

    2014-01-01

    If extinct and/or extant life is discovered on Mars, knowledge of the chronology of the biosphere will be of paramount importance. KArLE will provide absolute ages of Mars 2020 rocks, which will allow us to understand them in the context of Mars' geologic history, connect them to other landing sites, and compare Martian epochs of habitability with the Earth's history and evolution of life. KArLE significantly enhances the ability of Mars 2020 to meet its science objectives by performing in situ age dating on key lithologies, enabling targeted searches for ancient biosignatures and increasing the chances of identifying evidence for Martian microbial life. The KArLE investigation makes its measurements on a core sample obtained with the rover drill, inserted into a small, mechanically simple chamber, followed by interrogation by laser-induced breakdown spectroscopy (LIBS), mass spectrometry, and optical imaging. The KArLE experiment is flexible enough to accommodate any partner providing these instrument components, a creative approach that extends the ability of the Mars 2020 payload to accomplish an additional highly-desirable science measurement for low cost and risk and minimal extra hardware.

  1. Produce Live News Broadcasts Using Standard AV Equipment: A Success Story from the Le Center High School in Minnesota.

    ERIC Educational Resources Information Center

    Rostad, John

    1997-01-01

    Describes the production of news broadcasts on video by a high school class in Le Center, Minnesota. Topics include software for Apple computers, equipment used, student responsibilities, class curriculum, group work, communication among the production crew, administrative and staff support, and future improvements. (LRW)

  2. Environmental exposure to chromium compounds in the valley of León, México.

    PubMed Central

    Armienta-Hernández, M A; Rodríguez-Castillo, R

    1995-01-01

    The effects on the environment and health of the operation of a chromate compounds factory and tanneries in the León valley in central México are discussed. Sampling and analysis of chromium were performed in water, soil, and human urine. Groundwater has been polluted in an area of about 5 km2 by the leaching of a solid factory waste, which results in concentrations up to 50 mg/l of hexavalent chromium. The plume shape and extension appear to be controlled by the prevailing well extraction regime. Total chromium was detected in the soil around the factory as a result of both aerial transport and deposition of dust produced in the chromate process and irrigation with tannery-contaminated water. Analysis of the impact of chromium in air and water on populations with various degrees of exposure revealed that highly harmful health effects were not observed. PMID:7621799

  3. Qui sera le nouvel Einstein ? Vers une nouvelle theorie de la gravitation

    NASA Astrophysics Data System (ADS)

    Bonnet-Bidaud, J. M.

    1999-10-01

    Un debat de plus d'un siecle a resurgi ces toutes dernieres annees avec une vigueur nouvelle. L'enjeu ? Mettre fin, ni plus ni moins, a l'une des contradictions les plus inouies de la physique fondamentale, en reconciliant mecanique quantique et relativite generale. En effet, a l'heure ou la gravitation semble enfin sur le point de fusionner avec les trois autres forces de la nature. il est certain que la relativite d'Einstein doit etre bientot remplacer par une autre theorie... Reste quye tous les physiciens sont loin de s'accorder sur la marche a suivree. Gravitation quantique, relativite d'echelle, supersymetrie, les candidates ne manquent pas.

  4. Surgical Management of Aggressive Central Giant Cell Granuloma of Maxilla through Le Fort I Access Osteotomy

    PubMed Central

    Reddy, G. V.; Reddy, G. Siva Prasad; Reddy, N. V. S. Sekhar; Kumar, Aswin

    2012-01-01

    Giant cell granuloma (GCG) is an uncommon bony lesion in the head and neck region, most commonly affecting the maxilla and mandible and has a female predilection. The clinical behavior of central GCG ranges from a slowly growing asymptomatic swelling to an aggressive lesion. The clinical, radiological, histological features and management of an aggressive GCG of maxilla in an 18-year-old female patient are described and discussed. It is emphasized that surgery is the traditional and still the most accepted treatment for GCG. Le Fort I osteotomy has been advocated as one of the access osteotomy for the surgical management of aggressive and extensive GCG involving the maxilla. The postoperative morbidity and recurrence have been discussed. PMID:22754742

  5. Review of the Nearctic genus Lacconotus LeConte (Coleoptera, Mycteridae, Eurypinae)

    PubMed Central

    Pollock, Darren; Majka, Christopher G.

    2012-01-01

    Abstract Lacconotus LeConte, the sole Nearctic representative of the eurypine Mycteridae, is revised, based on morphological features of adults. The following syn. n. is proposed: Lacconotus pallidus Van Dyke, 1928 = Lacconotus pinicola Horn, 1879. The former is a light-colored form with a southern California distribution. A subgen. n., Alcconotus, is described for Lacconotus pinicola, producing the following comb. n.: Lacconotus (Alcconotus) pinicola (Horn). A lectotype is designated for Lacconotus pinicola. A key separating the two subgenera and species is provided, as are photographs and illustrations of salient structures of adults, and maps showing collection localities. Lacconotus punctatus is newly recorded in Alabama, Arkansas, Massachusetts, Oklahoma, Texas, and Wisconsin; Lacconotus pinicola is newly recorded in Arizona and Utah in the USA, and Baja California Norte in Mexico. Phenology information shows a north-to-south gradation in occurrence time. PMID:22303123

  6. Neonatal postcrania from Mezmaiskaya, Russia, and Le Moustier, France, and the development of Neandertal body form.

    PubMed

    Weaver, Timothy D; Coqueugniot, Hélène; Golovanova, Liubov V; Doronichev, Vladimir B; Maureille, Bruno; Hublin, Jean-Jacques

    2016-06-01

    Neandertal and modern human adults differ in skeletal features of the cranium and postcranium, and it is clear that many of the cranial differences-although not all of them-are already present at the time of birth. We know less, however, about the developmental origins of the postcranial differences. Here, we address this deficiency with morphometric analyses of the postcrania of the two most complete Neandertal neonates-Mezmaiskaya 1 (from Russia) and Le Moustier 2 (from France)-and a recent human sample. We find that neonatal Neandertals already appear to possess the wide body, long pubis, and robust long bones of adult Neandertals. Taken together, current evidence indicates that skeletal differences between Neandertals and modern humans are largely established by the time of birth. PMID:27217565

  7. Evaluation of an interactive multi-media device for delivering information on Le Fort I osteotomy.

    PubMed

    El Azem, Assem; Benington, Philip C M; Khambay, Balvinder S; Ayoub, Ashraf F

    2014-09-01

    This study was carried out on volunteers to evaluate a newly developed interactive software package aimed at informing prospective Le Fort I osteotomy patients regarding the surgical technique and possible complications. The aim of the study was to compare two methods of information delivery; a multi-media tablet device delivering both graphic and verbal information, and an audio device delivering essentially the same information in verbal form only. The null hypothesis was that there would be no difference between the efficiencies of the two methods. The subjects' ability to recall the information delivered by both devices was assessed using a questionnaire. The tablet device participants scored an average of 15.48 points, while the audio device participants scored an average of 268 points. The difference was statistically significant (p < 0.001), suggesting that the multi-media tablet device was more effective method. PMID:24534682

  8. The Portevin-Le Châtelier Effect in a Metastable Austenitic Stainless Steel

    NASA Astrophysics Data System (ADS)

    Müller, Alexandra; Segel, Christian; Linderov, Mikhail; Vinogradov, Alexei; Weidner, Anja; Biermann, Horst

    2016-01-01

    The Portevin-Le Châtelier (PLC) effect was investigated in a high-alloy metastable CrMnNi cast steel during tensile tests for the range of deformation temperatures between 293 K and 413 K (20 °C and 140 °C) and for nominal strain rates ranging between 10-4 and 10-1 s-1. Analysis of the stress-strain curves was complemented by in situ measurements of thermal and acoustic emissions as well as by digital image correlation, enabling determination of various local characteristics of plastic flow and clarification of individual contributions of different microscopic mechanisms involved in plastic deformation. It was shown that the PLC effect in the investigated CrMnNi steel was caused by the diffusion of interstitial atoms in the bcc phases.

  9. Neonatal postcrania from Mezmaiskaya, Russia, and Le Moustier, France, and the development of Neandertal body form

    PubMed Central

    Weaver, Timothy D.; Coqueugniot, Hélène; Golovanova, Liubov V.; Doronichev, Vladimir B.; Maureille, Bruno; Hublin, Jean-Jacques

    2016-01-01

    Neandertal and modern human adults differ in skeletal features of the cranium and postcranium, and it is clear that many of the cranial differences—although not all of them—are already present at the time of birth. We know less, however, about the developmental origins of the postcranial differences. Here, we address this deficiency with morphometric analyses of the postcrania of the two most complete Neandertal neonates—Mezmaiskaya 1 (from Russia) and Le Moustier 2 (from France)—and a recent human sample. We find that neonatal Neandertals already appear to possess the wide body, long pubis, and robust long bones of adult Neandertals. Taken together, current evidence indicates that skeletal differences between Neandertals and modern humans are largely established by the time of birth. PMID:27217565

  10. Who invented the mule deer (Odocoileus hemionus)? On the authorship of the fraudulent 1812 journal of Charles Le Raye

    USGS Publications Warehouse

    Woodman, Neal

    2015-01-01

    The captivity journal of Charles Le Raye was first published in 1812 as a chapter in A topographical description of the state of Ohio, Indiana Territory, and Louisiana, a volume authored anonymously by a late officer in the U. S. Army. Le Raye was purported to be a French Canadian fur trader who, as a captive of the Sioux, had travelled across broad portions of the Missouri and Yellowstone river drainages a few years before the Lewis and Clark expedition (1804-1806), and his account of the land, its people, and its natural resources was relied upon as a primary source by generations of natural historians, geographers, and ethnographers. Based directly on descriptions of animals in the published journal, the naturalist Constantine S. Rafinesque named seven new species of North American mammals, including what are currently recognized as the mule deer (Odocoileus hemionus) and a Great Plains subspecies of white-tailed deer (O. virginianus macrourus). Unfortunately, Le Raye never existed, and historical, geographical, and ethnographical evidence indicates that the journal is fraudulent. Determining the author of this work is relevant to identifying the sources used to construct it, which may help us to understand the real animals upon which Rafinesque's species are based. Traditionally, authorship of the volume was attributed to Jervis Cutler, but his role in composing the fraudulent Le Raye journal has been called into question. In this paper, I present additional evidence supporting the hypothesis that Jervis Cutler bears primary responsibility for the Le Raye journal and that he had the background, opportunity, and potential motive to author it.

  11. Humoral response against sialyl-Le(a) glycosylated protein species in esophageal cancer: Insights for immunoproteomic studies.

    PubMed

    Fernandes, Elisabete; Peixoto, Andreia; Neves, Manuel; Afonso, Luís Pedro; Santos, Lúcio Lara; Ferreira, José Alexandre

    2015-12-01

    Esophageal cancers (ECs) show poor prognosis and decreased overall survival due to late diagnosis and ineffective therapeutics, urging the introduction of novel biomarkers to aid disease management. The levels of sialyl-Lewis(a) antigen (sLe(a) ) are frequently increased in digestive tumours, which has been explored in serological non-invasive prognostication (CA19-9 test); however, with low sensitivity and specificity. Autoantibodies against cancer antigens are considered the next generation biomarkers, as they are present in circulation long before tumour-associated proteins. Based on these observations we have mined the serum of EC patients (n = 7) for antibodies against sLe(a) -glycosylated protein species. All EC were positive for sLe(a) , irrespectively of their histological nature but only two patients showed elevated CA19-9. Moreover, IgG titers, with emphasis on IgG1, were elevated in EC patients in comparison to the control group. SLe(a) -glycoproteins were then extracted from tumours of patients with negative CA19-9, isolated by immunoprecipitation and blotted with patients IgG. Autoantibodies against sLe(a) -glycosylated proteins were detected in all cases. Different SLe(a) -glycoproteins were observed for tumours of distinct histological natures, which now require identification and validation in larger patient sets. This preliminary data suggests that antoantibodies against sLe(a) glycosylated proteins hold potential for non-invasive diagnosis in CA19-9 negative cases and sets the rational for future immunoproteomic studies envisaging highly specific EC biomarkers. PMID:26333169

  12. The coiled-coil domain of EHD2 mediates inhibition of LeEix2 endocytosis and signaling.

    PubMed

    Bar, Maya; Sharfman, Miya; Schuster, Silvia; Avni, Adi

    2009-01-01

    Endocytosis has been suggested to be crucial for the induction of plant immunity in several cases. We have previously shown that two Arabidopsis proteins, AtEHD1 and AtEHD2, are involved in endocytosis in plant systems. AtEHD2 has an inhibitory effect on endocytosis of transferrin, FM-4-64, and LeEix2. There are many works in mammalian systems detailing the importance of the various domains in EHDs but, to date, the domains of plant EHD2 that are required for its inhibitory activity on endocytosis remained unknown. In this work we demonstrate that the coiled-coil domain of EHD2 is crucial for the ability of EHD2 to inhibit endocytosis in plants, as mutant EHD2 forms lacking the coiled-coil lost the ability to inhibit endocytosis and signaling of LeEix2. The coiled-coil was also required for binding of EHD2 to the LeEix2 receptor. It is therefore probable that binding of EHD2 to the LeEix2 receptor is required for inhibition of LeEix2 internalization. We also show herein that the P-loop of EHD2 is important for EHD2 to function properly. The EH domain of AtEHD2 does not appear to be involved in inhibition of endocytosis. Moreover, AtEHD2 influences actin organization and may exert its inhibitory effect on endocytosis through actin re-distribution. The coiled-coil domain of EHD2 functions in inhibition of endocytosis, while the EH domain does not appear to be involved in inhibition of endocytosis. PMID:19936242

  13. Imagerie Resolue dans le Temps des Photons et Neutres Metastables Emis D'une Surface Par Stimulation Electronique

    NASA Astrophysics Data System (ADS)

    Leclerc, Gregoire

    L'appareil que nous presentons ici a ete mis au point pour permettre d'accumuler des images numeriques, resolues dans le temps, de la desorption par stimulation electronique (DSE) d'ions positifs et negatifs, de photons et de neutres metastables, tout en conservant des capacites de base de diffraction d'electrons lents (DEL) et de transmission d'electrons lents (TEL). Le spectrometre comporte un monochromateur d'electrons a secteur cylindrique de 127^ circ dont l'optique de sortie permet la focalisation du faisceau d'electrons sur une large gamme d'energies. Le detecteur consiste en un empilement de galettes de microcanaux et d'une anode resistive a encodage de division de charges. La reponse spatiale du detecteur a ete calibree et plusieurs causes de non-linearite ont ete localisees et corrigees. Des methodes de correction materielle et logicielle des distorsions spatiales sont presentees. La resolution temporelle des evenements est obtenue en pulsant le faisceau d'electrons, et de facon synchrone la detection, laquelle est couplee a un micro-ordinateur. La premiere partie de ce travail est consacree a la caracterisation du spectrometre et la presentation de nombreux parametres operationnels, obtenus soit au moment de la conception, soit experimentalement. Suit la presentation de donnees de DEL et de DSE pour le systeme Ar/Pt(111) en films minces a 15K. Les sequences temporelles d'images de metastables d'Ar desorbes ont revele la presence de plusieurs populations distinctes, ayant des distributions angulaires et distributions d'energie cinetique que nous avons pu separer. Les fonctions d'excitation de l'emission de photons et de la desorption de differentes composantes de metastables, ainsi que la dependance de ces signaux sur l'epaisseur des films d'Ar, sont aussi presentees et analysees. Les techniques que nous avons developpees ont permis de cerner les mecanismes en jeu pour la desorption et la luminescence.

  14. Appendicite aigue non compliquée: y a-t- il une place pour le traitement conservateur

    PubMed Central

    El Khader, Ahmed; Lahkim, Mohamed; El Barni, Rachid; Achour, Abdessamad

    2015-01-01

    Le but de cette étude a été d’évaluer l'efficacité de l'antibiothérapie seule dans le traitement des appendicites aigues non compliquées. C'est une étude prospective, intéressant 68 patients ayant eu une appendicite aigue simple, de confirmation radiologique, traités par l'amoxicilline associée à l'acide clavulanique pendant 10 jours. L'appendicectomie a été réalisée en cas d'aggravation ou en cas de non amélioration au bout de 48heures de traitement. Le traitement conservateur a été efficace dans 82,35% avec une résolution complète des symptômes chez 56 patients. Les 12 cas restants (17,65%) ont subit une appendicectomie. l'appendicite a été gangréneuse dans 8 cas et phlegmoneuse dans 4 cas. Cinq des 56 patients, qui ont bien évolué sous traitement conservateur, ont été réadmis et opérés pour récidive, soit 8,9%. Deux cas ont eu une appendicite compliquée. L'appendicectomie reste le traitement de référence pour l'appendicite aigue, mais le traitement antibiotique peut être proposé en première intension à des patients présentant une appendicite aigue non compliquée. PMID:26327981

  15. The Coiled-Coil Domain of EHD2 Mediates Inhibition of LeEix2 Endocytosis and Signaling

    PubMed Central

    Bar, Maya; Sharfman, Miya; Schuster, Silvia; Avni, Adi

    2009-01-01

    Endocytosis has been suggested to be crucial for the induction of plant immunity in several cases. We have previously shown that two Arabidopsis proteins, AtEHD1 and AtEHD2, are involved in endocytosis in plant systems. AtEHD2 has an inhibitory effect on endocytosis of transferrin, FM-4-64, and LeEix2. There are many works in mammalian systems detailing the importance of the various domains in EHDs but, to date, the domains of plant EHD2 that are required for its inhibitory activity on endocytosis remained unknown. In this work we demonstrate that the coiled-coil domain of EHD2 is crucial for the ability of EHD2 to inhibit endocytosis in plants, as mutant EHD2 forms lacking the coiled-coil lost the ability to inhibit endocytosis and signaling of LeEix2. The coiled-coil was also required for binding of EHD2 to the LeEix2 receptor. It is therefore probable that binding of EHD2 to the LeEix2 receptor is required for inhibition of LeEix2 internalization. We also show herein that the P-loop of EHD2 is important for EHD2 to function properly. The EH domain of AtEHD2 does not appear to be involved in inhibition of endocytosis. Moreover, AtEHD2 influences actin organization and may exert its inhibitory effect on endocytosis through actin re-distribution. The coiled-coil domain of EHD2 functions in inhibition of endocytosis, while the EH domain does not appear to be involved in inhibition of endocytosis. PMID:19936242

  16. Enormes incidentalomes surrénaliens: rôle de l'imagerie médicale à propos de deux cas

    PubMed Central

    Nikièma, Zakari; Yaméogo, Aimé Arsène; N'Goran, Kouamé; Cissé, Rabiou

    2012-01-01

    Les auteurs rapportent une série de deux cas d’énormes incidentalomes surrénaliens rarement observés dans la littérature. Ils étaient de siège bilatéral dans le premier cas et unilatéral droit dans le second. Si le diagnostic étiologique est parfois aisé dans les pays à haute technologie médicale, il pose un problème majeur dans certaines structures sanitaires des pays à ressources limitées. Lele essentiel de l'imagerie est d’établir de manière précise, peu invasive et peu coûteuse que possible, la nature bénigne ou maligne de l'incidentalome surrénalien. L’échographie et la tomodensitométrie ont permis de faire le diagnostic positif chez nos patients. La sémiologie tomodensitométrique est caractéristique quand elle associe la morpho-structure de la masse et deux critères majeurs basés d'une part sur l'histologie et la physiologie et d'autre part la cinétique de rehaussement de la masse après injection de produit de contraste. Toutefois, la biologie et surtout la biopsie assurent le diagnostic étiologique. PMID:23396505

  17. Nitric oxide modulates Lycopersicon esculentum C-repeat binding factor 1 (LeCBF1) transcriptionally as well as post-translationally by nitrosylation.

    PubMed

    Kashyap, Prakriti; Sehrawat, Ankita; Deswal, Renu

    2015-11-01

    Nitric oxide (NO) production increases in the cold stress. This cold enhanced NO manifests its effect either by regulating the gene expression or by modulating proteins by NO based post-translational modifications (PTMs) including S-nitrosylation. CBF (C-repeat binding factor) dependent cold stress signaling is most studied cold stress-signaling pathway in plants. SNP (sodium nitroprusside, a NO donor) treatment to tomato seedlings showed four fold induction of LeCBF1 (a cold inducible CBF) transcript in cold stress. S-nitrosylation as PTM of CBF has not been analyzed till date. In silico analysis using GPS-SNO 1.0 software predicted Cys 68 as the probable site for nitrosylation in LeCBF1. The 3D structure and motif prediction showed it to be present in the beta hairpin loop and hence available for S-nitrosylation. LeCBF1 was cloned and expressed in Escherichia coli. LeCBF1 accumulated in the inclusion bodies, which were solubilized under denaturing conditions and purified after on column refolding by Ni-NTA His tag affinity chromatography. Purified LeCBF1 resolved as a 34 kDa spot with a slightly basic pI (8.3) on a 2-D gel. MALDI-TOF mass spectrometry identified it as LeCBF1 and western blotting using anti-LeCBF1 antibodies confirmed its purification. Biotin switch assay and neutravidin affinity chromatography showed LeCBF1 to be S-nitrosylated in presence of GSNO (NO donor) as well as endogenously (without donor) in cold stress treated tomato seedlings. Dual regulation of LeCBF1 by NO at both transcriptional as well as post-translational level (by S-nitrosylation) is shown for the first time. PMID:26255539

  18. Faut-il continuer à infiltrer le scalp par un anesthésique local pour une craniotomie?

    PubMed Central

    Doumiri, Mouhssine; Motiaa, Youssef; Razine, Rachid; Amor, Morad; Moussaoui, Abdelmajid; Kabbaj, Saad; Maazouzi, Wajdi

    2015-01-01

    Introduction Le maintien de la stabilité hémodynamique est un objectif primordial de l'anesthésie pour craniotomie. Peu d’études ont prouvé l'efficacité de l'infiltration du scalp par un anesthésique local pour le maintien de la stabilité hémodynamique après l'incision. L'objectif de notre travail est d’évaluer l'influence de l'infiltration de la ligne d'incision du scalp par la lidocaïne à 0,5% adrénalinée sur les paramètres hémodynamiques après incision pour craniotomie supratentorielle. Méthodes Étude prospective en double aveugle réalisée au bloc opératoire de l'hôpital des spécialités de Rabat sur une période d'une année incluant 80 malades programmés pour craniotomie supratentorielle. Les malades étaient randomisés par tirage au sort en 2 groupes: Le groupe 1 était infiltré par 40 ml du sérum salé adrénaliné (1/200 000) et le groupe 2 était infiltré par 40 ml de la lidocaïne 0,5% adrénalinée (1/200 000). Le critère de jugement principal était la pression artérielle moyenne (PAM) après l'incision. L’étude statistique a fait appel aux tests t de student et l'U- mann-whitney. Une valeur de p <0.05 était considérée significative. Résultats L’étude a inclus 80 patients (40 hommes et 40 femmes). L’âge moyen était 42,33±14,76 ans. Le poids moyen était 71,58 ±10 kg. Le 3/4 des patients était ASA 1, seulement 25% étaient ASA2. La durée moyenne de la chirurgie était de 252,06±38,62 mn. Les deux groupes étaient comparables concernant l’âge, le sexe, le poids, la durée d'intervention, le type d'abord chirurgical, la dose totale du fentanyl reçue jusqu'a l'incision, ainsi que les paramètres hémodynamiques avant l'incision. Après l'incision la FC moyenne a augmenté dans les deux groupes: 80,53±7,72 bpm dans le groupe contrôle et 76,85±8,52 bpm dans le groupe lidocaïne. La différence d'augmentation de la FC entre les deux groupes était statistiquement significative (p = 0,047). L

  19. La recherche de naines brunes autour d'etoiles du voisinage solaire et le spectrographe multi-objets SIMON

    NASA Astrophysics Data System (ADS)

    Albert, Loic

    Cette thèse comporte un volet d'instrumentation astronomique, le spectrographe infrarouge SIMON, et un volet de recherche, la recherche de naines brunes autour d'étoiles (lu voisinage solaire. Le premier volet fait état de la construction du Spectrographe infrarouge de Montréal (SIMON), un instrument polyvalent fonctionnant dans le proche infrarouge (0.8-2.5 [mu]m) conçu pour être utilisé à l'Observatoire du mont Mégantic (OMM) et au télescope Canada-France-Hawaii (TCFH). SIMON regroupe plusieurs fonctionnalités: l'irnagerie, la spectroscopie, la spectroscopie rnulti-objets et la polarimétrie. Comme imageur, il offre un champ de vue (le 7.7'x 7.7' à l'OMM et 3.3' x 3.3' au TCFH et possède huit filtres dont un filtre I . SIMON compte trois disperseurs pour la spectroscopie: (1) un prisme d'Amici R max [approximate]50, 0.8-2.5 [mu]m); (2) un grism de silice (R max [approximate]750, 1.17-2.34 [mu]m); et un grism de KRS-5 (R max [approximate]3000, bande J,H ou K S ). Le mode spectroscopique multi-objets utilise des masques cryogéniques placés dans un second cryostat et, couplé au prisme d'Amici, permet l'obtention d'une centaine de spectres simultanément. Le mode polarimétrique permet l'observation de quatre vecteurs de polarisation simultanément. Cette première moitié de thèse étaye les objectifs scientifiques, détaille la conception optique (collimatrice et caméra) et mécanique (un cryostat principal contenant trois cotres à filtres et le détecteur, un cryostat amovible contenant nue roue à masques), décrit l'électronique et le système d'acquisition, et enfin présente les performances dans les différents modes. Le second volet de cette thèse est un relevé grand champ à la recherche de naines brunes de type T autour de 66 étoiles du voisinage solaire. Il a été effectué en utilisant des caméras infrarouges (dont SIMON) et des CCD sur divers télescopes. Le diagramme I--J vs. J--H utilisé est. efficace pour isoler des naines T

  20. Le don après un décès d'origine cardiocirculatoire au Canada

    PubMed Central

    Shemie, Sam D.; Baker, Andrew J.; Knoll, Greg; Wall, William; Rocker, Graeme; Howes, Daniel; Davidson, Janet; Pagliarello, Joe; Chambers-Evans, Jane; Cockfield, Sandra; Farrell, Catherine; Glannon, Walter; Gourlay, William; Grant, David; Langevin, Stéphan; Wheelock, Brian; Young, Kimberly; Dossetor, John

    2006-01-01

    Résumé Ces recommandations sont le fruit d'un processus multidisciplinaire national ayant duré un an et visant à déterminer si et comment l'on pourrait procéder au don d'organes après un décès d'origine cardiocirculatoire («don après le décès cardiocirculatoire», ou DDC) au Canada. Le forum national organisé en février 2005 a permis aux participants de discuter et d'élaborer des recommandations sur les principes, interventions et pratiques se rapportant au DDC. Les aspects éthiques et juridiques ont été abordés dans les discussions. À la fin du Forum, la majorité des participants ont été favorables à l'implantation de programmes de DDC au Canada. Les participants du Forum ont également convenu qu'il fallait formuler et prôner des valeurs fondamentales pour orienter l'élaboration de programmes et de protocoles basés sur le cadre médical, éthique et juridique établi lors de cette réunion. Même si la possibilité d'un don d'organes et de tissus doit faire partie intégrante des soins de fin de vie, il faut insister sur le fait que le devoir de diligence envers les patients mourants et leurs familles doit demeurer la priorité des équipes soignantes. La complexité et les répercussions profondes du décès sont reconnues et doivent être respectées, de même que les différences personnelles, ethnoculturelles et religieuses face à la mort et au don d'organes. Les décisions d'arrêter le traitement de maintien des fonctions vitales, la prise en charge des derniers moments de la vie et le diagnostic de décès selon des critères cardiocirculatoires doivent être distincts et indépendants des processus de don et transplantation. Ce rapport contient des recommandations destinées aux gestionnaires de program, aux autorités sanitaires régionales et aux instances appelés à élaborer les protocoles de DDC. Les programmes doivent être conçus en fonction des éléments suivants : direction et planification locales, éducation et

  1. Ensemble des troubles causés par l'alcoolisation fœtale : lignes directrices canadiennes concernant le diagnostic

    PubMed Central

    Chudley, Albert E.; Conry, Julianne; Cook, Jocelynn L.; Loock, Christine; Rosales, Ted; LeBlanc, Nicole

    2005-01-01

    Résumé LE DIAGNOSTIC DE L'ENSEMBLE DES TROUBLES CAUSÉS PAR L'ALCOOLISATION FÉTALE (ETCAF) est complexe et l'élaboration de lignes directrices concernant le diagnostic est justifiée. Un sous-comité du Comité consultatif national de l'Agence de santé publique du Canada sur l'Ensemble des troubles causés par l'alcoolisation fœtale a examiné, analysé et intégré les méthodes de diagnostic actuelles afin de parvenir à une méthode de diagnostic normalisée faisant le consensus au Canada. L'objet du présent document est d'examiner et de clarifier l'utilisation des systèmes de diagnostic actuels et de formuler des recommandations quant à leur application pour le diagnostic des déficiences liées à l'ETCAF chez des individus de tous les âges. Les lignes directrices sont fondées sur un vaste consensus de praticiens et d'autres intervenants spécialisés dans le domaine. Ces lignes directrices ont été organisées en sept catégories, soit le dépistage et l'orientation vers les spécialistes, l'examen physique et le diagnostic différentiel, l'évaluation du comportement neurologique, le traitement et le suivi, les antécédents de consommation d'alcool de la mère pendant la grossesse, les critères du diagnostic pour le syndrome d'alcoolisation fœtale (SAF), SAF partiel et troubles neurologiques du développement liés à l'alcool, l'harmonisation de l'Institute of Medicine (IOM) et des approches du Code diagnostique à 4 chiffres. Le diagnostic exige une évaluation complète des antécédents, ainsi qu'un examen physique et du comportement neurologique, tout en recourant à une approche multidisciplinaire. Les présentes lignes directrices pour le diagnostic du syndrome d'alcoolisation fœtale et des déficiences qui y sont associées sont les premières à avoir été élaborées au Canada et elles sont fondées sur la consultation d'un grand éventail de spécialistes du diagnostic.

  2. Effet de l'interaction coulombienne sur la localisation d'Anderson dans le gaz bidimensionnel d'électrons

    NASA Astrophysics Data System (ADS)

    Fleury, G.

    2010-09-01

    Nous étudions l’effet des interactions coulombiennes sur la localisation d’Anderson dans le gaz bidimensionnel d’électrons désordonné. L’objectif est de statuer sur la question de l’existence de métaux à deux dimensions. En l’absence d’interaction, la théorie d’échelle de la localisation prédit qu’un désordre infinitésimal suffit à localiser la fonction d’onde électronique et donc à rendre le système isolant à température nulle (Abrahams et al., 1979). Dans certaines limites extrêmes, les interactions peuvent être prises en compte et l’on aboutit également à un état isolant. Cependant, aucune théorie analytique ne permet de traiter le régime quantique non-perturbatif où désordre et interaction sont intermédiaires. Expérimentalement, il est possible de l’explorer dans des échantillons de haute mobilité et basse densité. Depuis 1994, des comportements métalliques inexpliqués y ont été observés (Kravchenko et al., 1994). Nous avons mis au point une méthode numérique permettant d’étudier le problème couplé de la localisation d’Anderson en présence d’interaction. Cette méthode mêle Monte Carlo quantique à température nulle et théorie d’échelle pour la conductance de Thouless. Nous trouvons que la théorie d’échelle de la localisation est préservée en présence d’interaction et donc que le gaz bidimensionnel, même corrélé, est isolant à température nulle. Nos résultats montrent de plus que les interactions délocalisent le gaz bidimensionnel et que cet effet de délocalisation est accru en présence de dégénérescence de vallées. Ils nous permettent de proposer un mécanisme simple rendant compte des principales caractéristiques des comportements métalliques observés expérimentalement.

  3. Les astronomes européens auscultent les cieux avec le plus grand télescope du monde

    NASA Astrophysics Data System (ADS)

    Malbet, F.

    2008-09-01

    À l'heure des projets de télescopes extrêmement grands, l'Europe a déjà une longueur d'avance. Le télescope européen (VLT), en mode interférométrique avec l'instrument AMBER devient le plus grand télescope jamais utilisé dans le domaine optique aussi bien en surface de miroir (plus de 150 m2) qúen finesse de résolution qui atteint celle d'un télescope de 130 m de diamètre. Le journal professionnel Astronomy & Astrophysics a publié en 2007 un numéro spécial qui rapporte les premiers résultats obtenus avec l'instrument AMBER (Astronomical MultiBEam Recombiner) par le très grand télescope européen. Ces articles couvrent pratiquement tous les stades de l'évolution stellaire depuis la formation des étoiles et des planètes jusqu'a l'observation de l'explosion de type nova dans un système stellaire évolué. Ces résultats inédits ont été obtenus en utilisant simultanément 3 des 4 télescopes du VLT basés à l'Observatoire européen austral du mont Paranal au Chili. L'instrument AMBER équipant le VLTI (mode interférométrique du VLT) permet dâatteindre une résolution angulaire inégalée de l'ordre du millième de seconde d'angle autorisant l'observation des astres dans différentes longueurs d'onde, dans l'infrarouge proche. Les astronomes obtiennent donc des observations avec une finesse 13 fois plus importante que celle d'un télescope seul. Il devient alors possible de sonder les régions de formation de planètes, d'observer les vents des étoiles en rotation très rapide, d'étudier les différents types de matières éjectées par une étoile massive, de séparer les deux composantes d'une étoile double serrée et de voir en direct l'évolution d'une nova quelques jours seulement après son explosion.

  4. Le médulloblastome chez l'adulte: à propos de 13 cas et revue de la literature

    PubMed Central

    Drissi, Jamal; Affane, Mariam; Elomrani, Abdelhamid; Khouchani, Mouna

    2015-01-01

    Le médulloblastome est une tumeur neuro-ectodermique primitive maligne. Il s'agit d'une tumeur rare chez l'adulte, représentant moins de 1% des tumeurs cérébrales. Nous proposons une étude rétrospective réalisée au sein du service d'Oncologie-Radiothérapie du CHU Mohamed VI de Marrakech sur une période de 13 ans. Le but de notre travail est de déterminer le profil épidémioclinique, thérapeutique, évolutif ainsi que les facteurs pronostiques de cette entité pathologique avec une revue de la littérature. Notre série comportait 13 patients, 10 hommes et 3 femmes, l’âge médian a été 20,8 ans. Le tableau clinique a été révélé par un syndrome d'hypertension intracrânienne (100%), associée à un syndrome cérébelleux (84%). La localisation était hémisphérique (31%) et vermio-hémisphérique (54%). 31% des patients ont bénéficié d'une exérèse chirurgicale totale. 85% des cas avaient une variante classique et 15% une variante desmoplasique. 30% des cas avaient été classés à «risque standard» et 70% à «haut risque». La chirurgie avait été complétée d'une radiothérapie de l'ensemble du névraxe selon la technique de «jonctions mobiles» dans tous les cas. Le délai moyen était de 73 jours. Une chimiothérapie adjuvante avait été réalisée chez 9 cas. Avec un recul moyen de 21.3 mois, l’évolution a été marquée par une récidive tumorale (4 cas), une toxicité auditive (6 cas) et des troubles cognitifs chez un cas. La prise en charge du médulloblastome doit être multidisciplinaire associant neurochirurgiens et oncologues radiothérapeutes. Cette collaboration est le seul garant d'une amélioration de son pronostic. PMID:26889307

  5. Apport de l'orientation clinique dans le diagnostic des hypertensions arterielles endocriniennes

    PubMed Central

    El Aziz, Siham; Chadli, Asma; Louda, Fatima; El Ghomari, Hassan; Farouqi, Ahmed

    2014-01-01

    L'hypertension artérielle d'origine endocrinienne représente une cause curable d'hypertension artérielle (HTA), ce qui en justifie le dépistage. Une orientation clinique est souhaitable afin de prescrire les bilans adéquats, notamment dans les pays en voie de développement. L'objectif de notre étude est décrire les aspects cliniques des patients ayant une HTA endocrinienne diagnostiquée au CHU de Casablanca. Méthodes: Il s'agit d'une étude descriptive rétrospective de 2004 à 2011, incluant tout patient ayant une HTA endocrinienne (en dehors des dysthyroïdies) admis en Endocrinologie. Les données concernant les facteurs cliniques, paracliniques et thérapeutiques ont été colligées. Au cours de la période étudiée, 53 cas d'HTA endocrinienne ont été admis, avec une age moyen au diagnostic de 39,3 ans et un sex-ratio F/H de 3,9. Trente patients (56.6%) ont un age ont un âge inférieur à 40 ans. On ne retrouve pas d'hérédité tensionelle chez 88.7% des patients. Les étiologies sont le Syndrome de cushing (41.5%), le phéochromocytome (32%), les adénomes somatotropes (15%) et les hyperaldostéronismes primaire (7.5%). L'HTA est essentiellement de grade un ou deux (69.8%), avec un retentissement cardio-vasculaire chez 11 patients (20.7%). Les patients ayant un SC avaient tous des signes cutanés spécifiques. Il s'agissait de sujets jeunes avec plusieurs facteurs de risque cardiovasculaire. Nous avons retrouvé un amaigrissement chez 37.5% des patients ayant un phéochromocytome avec un indice de masse corporel moyen de 20 kg/m2. L'HTA était permanente dans 5 cas de phéochromocytomes. Il n'existait pas d'hypokaliémie chez 50% des patients ayant un hyperaldostéronisme. Les signes cliniques des patients ayant une acromégalie étaient francs, avec un age moyen plus élevé de 50 ans. Nous avons noté une régression de l'HTA chez 59% de ces patients après guérison de l'endocrinopathie en cause. Plusieurs signes cliniques peuvent nous

  6. Thermal characterization of Li-ion cells using calorimetric techniques

    SciTech Connect

    ROTH,EMANUEL P.

    2000-05-31

    The thermal stability of Li-ion cells with intercalating carbon anodes and metal oxide cathodes was measured as a function of state of charge and temperature for two advanced cell chemistries. Cells of the 18650 design with Li{sub x}CoO{sub 2} cathodes (commercial Sony cells) and Li{sub x}Ni{sub 0.8}Co{sub 0.2}O{sub 2} cathodes were measured for thermal reactivity. Accelerating rate calorimetry (ARC) was used to measure cell thermal runaway as a function of state of charge (SOC), microcalorimetry was used to measure the time dependence of thermal output, and differential scanning calorimetry (DSC) was used to study the thermal reactivity of the individual components. Thermal decomposition of the anode solid electrolyte interphase (SEI) layer occurred at low temperatures and contributes to the initiation of thermal runaway. Low temperature reactions from 40 C--70 C were observed during the ARC runs that were SOC dependent. These reactions measured in the microcalorimeter decayed over time with power-law dependence and were highly sensitive to SOC and temperature. ARC runs of aged and cycled cells showed complete absence of these low-temperature reactions but showed abrupt exothermic spikes between 105--135 C. These results suggest that during aging the anode SEI layer is decomposing from a metastable state to a stable composition that is breaking down at elevated temperatures.

  7. Calorimetric determinations and theoretical calculations of polymorphs of thalidomide

    NASA Astrophysics Data System (ADS)

    Lara-Ochoa, F.; Pérez, G. Espinosa; Mijangos-Santiago, F.

    2007-09-01

    The analysis of the thermograms of thalidomide obtained for the two reported polymorphs α and β by differential scanning calorimetry (DSC) shows some inconsistencies that are discussed in the present work. The conception of a new polymorph form, named β ∗, allowed us to explain the observed thermal behavior more satisfactorily. This new polymorph shows enantiotropy with both α and β polymorphs, reflected in the unique endotherm obtained in the DSC-thermograms, when a heating rate of 10 °C/min is applied. Several additional experiments, such as re-melting of both polymorph forms, showed that there is indeed a new polymorph with an endotherm located between the endotherms of α and β. IR, Raman, and powder X-ray permit us to characterize the isolated compound, resulting from the re-melting of both polymorph forms. Mechanical calculations were performed to elucidate the conformations of each polymorph, and ab initio quantum chemical calculations were performed to determine the energy of the more stable conformers and the spatial cell energy for both polymorphs α and β. These results suggested a possible conformation for the newly discovered polymorph β ∗.

  8. Calorimetric glass transition in a mean-field theory approach

    PubMed Central

    Mariani, Manuel Sebastian; Parisi, Giorgio; Rainone, Corrado

    2015-01-01

    The study of the properties of glass-forming liquids is difficult for many reasons. Analytic solutions of mean-field models are usually available only for systems embedded in a space with an unphysically high number of spatial dimensions; on the experimental and numerical side, the study of the properties of metastable glassy states requires thermalizing the system in the supercooled liquid phase, where the thermalization time may be extremely large. We consider here a hard-sphere mean-field model that is solvable in any number of spatial dimensions; moreover, we easily obtain thermalized configurations even in the glass phase. We study the 3D version of this model and we perform Monte Carlo simulations that mimic heating and cooling experiments performed on ultrastable glasses. The numerical findings are in good agreement with the analytical results and qualitatively capture the features of ultrastable glasses observed in experiments. PMID:25675523

  9. Two Calorimetrically Distinct States of Liquid Water Below 150 Kelvin

    PubMed

    Johari; Hallbrucker; Mayer

    1996-07-01

    Vapor-deposited amorphous solid and hyperquenched glassy water were found to irreversibly transform, on compression at 77 kelvin, to a high-density amorphous solid. On heating at atmospheric pressure, this solid became viscous water (water B), with a reversible glass-liquid transition onset at 129 +/- 2 kelvin. A different form of viscous water (water A) was formed by heating the uncompressed vapor-deposited amorphous solid and hyperquenched liquid water. On thermal cycling up to 148 kelvin, water B remained kinetically and thermodynamically distinct from water A. The occurrence of these two states, which do not interconvert, helps explain both the configurational relaxation of water and stress-induced amorphization. PMID:8688057

  10. Calorimetric calibration of pyroelectric gamma-radiation detectors

    SciTech Connect

    Strakovskaya, R.Y.; Sras', A.G.

    1985-07-01

    A method has been devised for calibrating a pyroelectric dosimeter, which is based on comparing the readings obtained with it in a gamma-ray beam with the readings of an integral calorimeter under stationary conditions, with the latter previously calibrated from Joule heat. The calorimeter used was in the form of a closed shell, whose overall thermo-emf was independent of the spatial distribution of the heat sources in it, the value being proportional to the integral heat flux through the shell. Measurements were made not only with a quasiisotropic radiation field but also in directed fields. The overall error in calibrating the pyroelectric detectors by this method was less than or equal to plus or minus 10%.

  11. Calorimetric thermometry of meteoritic troilite: Preliminary thermometer relationships

    NASA Technical Reports Server (NTRS)

    Allton, Judith H.; Wentworth, Susan J.; Gooding, James L.

    1994-01-01

    Thermodynamic properties of the alpha/beta phase transformation in terrestrial troilite (FeS), as measured by differential scanning calorimetry (DSC), vary systematically with prior thermal history of the troilite, as imposed under laboratory conditions. Both the transition temperature and enthalpy change for the alpha/beta transformation decrease with increasing maximum temperature of prior heat treatment. DSC measurements on troilite from various meteorites indicate clear differences in the alpha/beta thermodynamic properties that are consistent with differences in the natural thermal histories of the meteorites.

  12. Calorimetric studies of the elongation of Avena coleoptile segments.

    PubMed

    Bogie, H E; Kresheck, G C; Harmet, K H

    1976-06-01

    Elongation rate and heat produced by Avena coleoptile segments suspended in sucrose buffer solutions were measured at pH values from 3.5 to 8.5. The caloric efficiency of elongation (CEE) was defined as the ratio of the rate of elongation to the rate of heat production. Elongation and CEE were greatest at intermediate pH values, but heat production (about 1 cal/g.hr) was insensitive to pH within the limits of experimental error (+/-20%). Quantitative agreement was found between the results of previous respiration studies and the rate of heat production in an aerobic atmosphere, which indicates that oxidative metabolism accounts for essentially all energy changes in the cell, so matter flow is a significant component of the bioenergetics of cell function. Indole-3-acetic acid up to 1 mm, produced about a 10-fold increase in elongation rate, a 5-fold increase of the CEE, and a 25% increase in heat production. Above this concentration, sharp drops in both elongation and heat production occurred, without altering the CEE at pH 6.5, but greatly decreasing the CEE at pH 4.5. Elongation and CEE showed marked decreases after 4 hours in an anaerobic atmosphere, but heat production did not exhibit a proportional decrease. These studies indicate that rate of cell elongation in the presence and absence of auxin is not directly proportional to the overall metabolism of the cell. PMID:16659582

  13. A calorimetric investigation of doxorubicin-polymer bead interactions.

    PubMed

    Waters, Laura J; Swaine, Tanya S; Lewis, Andrew L

    2015-09-30

    Isothermal titration calorimetry (ITC) was utilised to investigate suitability of the technique to determine the stoichiometry and thermodynamics of the interactions that occur between a commonly used chemotherapeutic drug, namely doxorubicin, and a polymer bead-based drug delivery embolisation system (DC Bead™). Six temperatures were selected for drug-polymer titrations (293-313 K) and in all cases an initially exothermic signal reverted to an endothermic response upon the saturation of the beads with drug. From these experiments, and subsequent calculations, the molar ratio of drug to SO3(-) (polymer) was found to be 0.4:1 at all temperatures studied. Enthalpic data was calculated from the raw ITC data with an average enthalpy of drug-polymer binding of - 14.8 kJ mol(-1) at 293 K through to - 19.4 kJ mol(-1) at 313 K implying the process is enthalpically-driven yet only affected by an increase in experimental temperature to a limited extent whereby an increase in experimental temperature results in a small increase in the negativity in change in enthalpy recorded. The application of ITC in this study (with its unique ability to monitor real-time interactions and facilitate stoichiometric calculations) resolves the lack of knowledge regarding the thermodynamics of this specific drug-polymer interaction. This study confirms that ITC is not only useful for this specific system, but also highlights the potential use of ITC for more general studies in this area. PMID:26209073

  14. Calorimetric study of Skyrmionic chiral magnet MnSi

    NASA Astrophysics Data System (ADS)

    Samatham, S. Shanmukharao; Ganesan, V.

    2014-04-01

    We present the analysis of specific internal energy as a function of magnetic fields in ordered, intermediate and paramagnetic phases of MnSi. Signatures of the formation of Skyrmion lattice, in conical order region, is identified by a hump-like structure in region-I. Gradual melting of blue phase, with magnetic fields, is demonstrated.

  15. A calorimetric study of precipitation in aluminum alloy 2219

    NASA Astrophysics Data System (ADS)

    Papazian, John M.

    1981-02-01

    Precipitate microstructures in aluminum alloy 2219 were characterized using transmission electron microscopy (TEM) and differential scanning calorimetry (DSC). The DSC signatures of individual precipitate phases were established by comparing the DSC and TEM results from samples that had been aged such that only one precipitate phase was present. These signatures were then used to analyze the commercial tempers. It was found that DSC could readily distinguish between the T3, T4, T6, T8 and O tempers but could not distinguish amongst T81, T851 and T87. Small amounts of plastic deformation between solution treatment and aging had a significant effect on the thermograms. Aging experiments at 130 and 190 °C showed that the aging sequence and DSC response of this alloy were similar to those of pure Al-Cu when the increased copper content is taken into account. Further aging experiments at temperatures between room temperature and 130 °C showed pronounced changes of the GP zone dissolution peak as a function of aging conditions. These changes were found to be related to the effect of GP zone size on the metastable phase boundary and on the GP zone dissolution kinetics.

  16. Calorimetric studies of natural talc: Enthalpy of dehydroxylation

    NASA Astrophysics Data System (ADS)

    Ogorodova, L. P.; Kiseleva, I. A.

    2011-10-01

    The standard dehydroxylation enthalpy of natural talc Mg3[Si4O10](OH)2 (87.8 ± 9.0 kJ/mol at 298.15 K) and the enthalpy of formation of dehydrated talc from the elements (Δf H {el/o} (298.15 K) = -5527.0 ± 9.0 kJ/mol) were determined for the first time using Hess's law, based on the total values of the enthalpy increments in heating a sample from room temperature to 973 K and the enthalpies of dissolution at 973 K for dehydrated talc measured in this work and those previously determined for talc and corresponding oxides.

  17. Calorimetric evaluation of commercial Ni-MH cells and charges

    NASA Technical Reports Server (NTRS)

    Darcy, Eric C.; Hughes, Brent M.

    1995-01-01

    The test objectives are to evaluate the electrical and thermal performance of commercial Ni-MH cells and to evaluate the effectiveness of commercial charge control circuits. The ultimate design objectives are to determine which cell designs are most suitable for scale-up and to guide the design of future Shuttle and Station based battery chargers.

  18. Superconducting calorimetric alpha particle sensors for nuclear nonproliferation applications

    SciTech Connect

    Horansky, Robert D.; Ullom, Joel N.; Beall, James A.; Hilton, Gene C.; Irwin, Kent D.; Dry, Donald E.; Hastings, Elizabeth P.; Lamont, Stephen P.; Rudy, Clifford R.; Rabin, Michael W.

    2008-09-22

    Identification of trace nuclear materials is usually accomplished by alpha spectrometry. Current detectors cannot distinguish critical elements and isotopes. We have developed a detector called a microcalorimeter, which achieves a resolution of 1.06 keV for 5.3 MeV alphas, the highest resolving power of any energy dispersive measurement. With this exquisite resolution, we can unambiguously identify the {sup 240}Pu/{sup 239}Pu ratio in Pu, a critical measurement for ascertaining the intended use of nuclear material. Furthermore, we have made a direct measurement of the {sup 209}Po ground state decay.

  19. Simulated performance of the calorimetric electron telescope (CALET) experiment

    NASA Astrophysics Data System (ADS)

    Akaike, Y.; Taira, K.; Kasahara, K.; Torii, S.; Shimizu, Y.; Yoshida, K.; CALET Collaboration

    2010-03-01

    CALET is a detector planned to be on-board the Japanese Experiment Module Exposed Facility (JEM-EF) of the International Space Station. The CALET mission aims at revealing unsolved problems in high energy phenomena of the Universe by carrying out a precise measurement of the high energy electrons in 1 GeV-20 TeV, the gamma-rays in 20 MeV to a few TeV and the nuclei in a few 10 GeV-1000 TeV. The main detector is composed of imaging calorimeter (IMC), total absorption calorimeter (TASC), silicon pixel array (SIA) and anti-coincidence detector (ACD) to detect various kinds of particles in very wide energy range. The total absorber thickness is 31 radiation lengths for electromagnetic particles and 1.4 interaction mean free paths for protons. Monte Carlo simulation study has been carried out for optimization of the detector performance in observing each kind of particles. We obtained following performance about the observation of very high energy (>100 GeV) electrons, which is a main target of the CALET experiment: (1) Effective geometrical factor is about 7000 cm2 sr. (2) Energy resolution is better than a few %. (3) Angular resolution is better than 0.1°. (4) Proton rejection power is ˜105 with the electron detection efficiency better than 95%. We also present the simulated performance of the CALET experiment in observing other particles.

  20. Binding of nucleotides to nucleoside diphosphate kinase: a calorimetric study.

    PubMed

    Cervoni, L; Lascu, I; Xu, Y; Gonin, P; Morr, M; Merouani, M; Janin, J; Giartosio, A

    2001-04-17

    The source of affinity for substrates of human nucleoside diphosphate (NDP) kinases is particularly important in that its knowledge could be used to design more effective antiviral nucleoside drugs (e.g., AZT). We carried out a microcalorimetric study of the binding of enzymes from two organisms to various nucleotides. Isothermal titration calorimetry has been used to characterize the binding in terms of Delta G degrees, Delta H degrees and Delta S degrees. Thermodynamic parameters of the interaction of ADP with the hexameric NDP kinase from Dictyostelium discoideum and with the tetrameric enzyme from Myxococcus xanthus, at 20 degrees C, were similar and, in both cases, binding was enthalpy-driven. The interactions of ADP, 2'deoxyADP, GDP, and IDP with the eukaryotic enzyme differed in enthalpic and entropic terms, whereas the Delta G degrees values obtained were similar due to enthalpy--entropy compensation. The binding of the enzyme to nonphysiological nucleotides, such as AMP--PNP, 3'deoxyADP, and 3'-deoxy-3'-amino-ADP, appears to differ in several respects. Crystallography of the protein bound to 3'-deoxy-3'-amino-ADP showed that the drug was in a distorted position, and was unable to interact correctly with active site side chains. The interaction of pyrimidine nucleoside diphosphates with the hexameric enzyme is characterized by a lower affinity than that with purine nucleotides. Titration showed the stoichiometry of the interaction to be abnormal, with 9--12 binding sites/hexamer. The presence of supplementary binding sites might have physiological implications. PMID:11294625

  1. Calorimetric studies of the growth of anaerobic microbes.

    PubMed

    Miyake, Hideo; Maeda, Yukiko; Ishikawa, Takashi; Tanaka, Akiyoshi

    2016-09-01

    This article aims to validate the use of calorimetry to measure the growth of anaerobic microbes. It has been difficult to monitor the growth of strict anaerobes while maintaining optimal growth conditions. Traditionally, optical density and ATP concentration are usually used as measures of the growth of anaerobic microbes. However, to take these measurements it is necessary to extract an aliquot of the culture, which can be difficult while maintaining anaerobic conditions. In this study, calorimetry was used to continuously and nondestructively measure the heat generated by the growth of anaerobic microbes as a function of time. Clostridium acetobutylicum, Clostridium beijerinckii, and Clostridium cellulovorans were used as representative anaerobic microbes. Using a multiplex isothermal calorimeter, we observed that peak time (tp) of C. acetobutylicum heat evolution increased as the inoculation rate decreased. This strong correlation between the inoculation rate and tp showed that it was possible to measure the growth rate of anaerobic microbes by calorimetry. Overall, our results showed that there is a very good correlation between heat evolution and optical density/ATP concentration, validating the use of the method. PMID:27012376

  2. Contrôle du marché informel à l’heure de la mondialisation des échanges. Le cas des antirétroviraux au Chili

    PubMed Central

    Brousselle, Astrid; Morales, Cristián

    2013-01-01

    Résumé Les nouveaux médicaments pour le VIH/sida ont créé des besoins d’accessibilité aux traitements que les gouvernements n’ont pas toujours réussi à couvrir. Il en résulte l’émergence d’un marché informel des ARV. Par l’analyse de la situation au Chili, nous traitons des différents créneaux d’approvisionnement, des conséquences de l’existence d’un tel marché, ainsi que des moyens envisageables pour réduire les effets indésirables. Les aspects tant microéconomiques que macroéconomiques concernant le marché et l’accessibilité aux médicaments sont abordés. PMID:23997580

  3. Lele du médecin anesthésiste-réanimateur dans la prise en charge de la femme enceinte porteuse de la maladie de Von Willebrand

    PubMed Central

    Baouahi, Hanane; Zerqouni, Yassine; Doumiri, Mouhcine; Oudghiri, Nezha; Saoud, Anas Tazi

    2015-01-01

    La maladie de Von Willebrand (VWD) est la maladie hémorragique constitutionnelle de l'hémostase la plus fréquente. Elle est liée à un déficit, soit quantitatif, soit qualitatif en facteur willebrand (VWF). Elle se caractérise par son extrême hétérogénéité sur les plans clinique, phénotypique et génotypique. La grossesse et surtout le péri-partum représente une période à risque hémorragique pour ces femmes. Nous rapportons le cas d'une parturiente présentant une maladie de Von Willebrand de type 1 documentée, la difficulté du choix du mode d'accouchement et de la technique anesthésique a été revue. PMID:26977242

  4. Sacroiliites infectieuses dans le centre tunisien: étude rétrospective de 25 cas

    PubMed Central

    Bellazreg, Foued; Alaya, Zeineb; Hattab, Zouhour; Lasfar, Nadia Ben; Ayeche, Mohamed Laziz Ben; Bouajina, Elyes; Letaief, Amel; Hachfi, Wissem

    2016-01-01

    Les sacroiliites infectieuses sont rares mais peuvent se compliquer de séquelles fonctionnelles invalidantes. Décrire les caractéristiques cliniques et bactériologiques des sacroiliites infectieuses chez les patients suivis à Sousse, Centre Tunisien. Etude rétrospective, descriptive, des cas de sacroiliites infectieuses chez les patients hospitalisés à Sousse entre 2000 et 2015. Le diagnostic a été retenu devant des signes cliniques, d'imagerie, et microbiologiques évocateurs. Vingt-cinq patients, 10 hommes et 15 femmes, d’âge moyen 41 ans (19-78) ont été inclus. Les sacroiliites étaient dues à des bactéries pyogènes dans 14 cas (56%), brucelliennes dans 6 cas (24%), et tuberculeuses dans 5 cas (20%). La durée moyenne d’évolution était de 61, 45 et 402 jours respectivement. Les signes cliniques les plus fréquents étaient les douleurs fessières (92%) et la fièvre (88%). La radiographie standard était anormale dans 75% des cas. La TDM et l'IRM sacro-iliaques dans tous les cas. Le diagnostic a été confirmé bactériologiquement dans 24 cas (96%). La durée moyenne d'antibiothérapie était de 83 jours dans les sacroiliites à pyogènes, et de 102 jours dans les SI brucelliennes. L’évolution était favorable chez 12 patients (48%), 9 patients (36%) ont gardé une douleur sacro-iliaque séquellaire, et 4 patients (16%) sont décédés. Dans notre étude, la durée d’évolution de la sacroiliite infectieuse ne permettait pas de prédire la bactérie responsable, d'où la nécessité d'obtenir une documentation bactériologique afin de prescrire une antibiothérapie appropriée. PMID:27583067

  5. [The Le Camus apothecary-grocers in Paris from the XVth to the XVIIth century. Nicolas IV Le Camus owned the Pavillon des Singes in the Rue Saint-Honoré, the residence of the Pocquelin family].

    PubMed

    Warolin, Christian

    2011-02-01

    Five members of the Le Camus family of Paris were apothecary-grocers, a situation passed down from father to son from the end of the reign of Charles VII up to the reign of Louis XIV, in other words for nearly two centuries. Four of them were called Nicolas and the fifth Jehan. Nicolas I practised his trade in the Rue Saint-Antoine; Nicolas II and Jehan lived in the district of Les Halles, on the corner of the Rue Saint-Denis and the Rue de la Chanvrerie. Nicolas IV was a tenant in a house at the crossroads of the Rue Saint-Honoré and the Rue des Poulies, later absorbed by the opening of the Rue du Louvre. In 1638, Nicolas IV bought the house known as "Le Pavillon des Singes" on the corner of the Rue Saint-Honoré and the Rue des Vieilles Etuves (now the Rue Sauval), the home of the family of Jean Pocquelin, father of Jean-Baptiste, the future Molière. When Nicolas IV died, his goods were divided between his son François, lawyer in Parliament, and his daughter Anne who inherited the "Pavillon des Singes". In 1680, she sold it to an administrator of the Hôtel-Dieu. Nicolas IV Le Camus was the last Parisian apothecary of this dynasty and no other Le Camus practised pharmacy in Paris until the Royal Declaration of 25th April 1777 which created the College of Pharmacy and the Master of Pharmacy. PMID:21661226

  6. Transport adiabatique et phases de Berry : application au contrôle quantique cohérent passif

    NASA Astrophysics Data System (ADS)

    Viennot, D.

    2004-11-01

    L'étude de l'interaction d'atomes ou de molécules avec des champs électromagnétiques intenses, nécéssite le développement de nouveaux outils de modélisation rendant compte de la dynamique quantique de ces systèmes. Une approche purement perturbative étant impossible en champs forts, on s'est tourné vers une approche “adiabatique”. Afin de traiter correctement le cas des croisements de valeurs propres, on a généralisé les formules de transport adiabatique en faisant intervenir une généralisation de la phase de Berry non-abélienne.

  7. Baisse du HDL-cholestérol indicateur du stress oxydatif dans le diabète de type 2

    PubMed Central

    Kabamba, Arsène Tshikongo; Bakari, Salvius Amuri; Longanga, Albert Otshudi; Lukumwena, Zet Kalala

    2014-01-01

    L'hypercholestérolémie est étroitement liée au stress oxydatif. Lorsqu'il y a trop de cholestérol qui circule dans le sang, il n'est pas utilisé en totalité par les cellules et il risque de s'accumuler dans les vaisseaux sanguins. Cela peut entrainer la formation des plaques d'athérosclérose qui gênent la circulation sanguine et provoquent des accidents cardiovasculaires. Le stress oxydatif apparait très tôt dans l'histoire des complications du diabète de type 2, et est lié à l'oxydation du glucose mais aussi à la peroxydation lipidique. Le cholestérol-HDL est un marqueur important du stress oxydatif par sa capacité à faciliter la métabolisation du cholestérol, sa baisse est souvent considérée comme la source de beaucoup d'inquiétudes. L'objectif est l’évaluation de la variation du taux de cholestérol-HDL, marqueur du stress oxydatif, chez les patients diabétiques de type 2 dans la population congolaise. Nous avons inclus dans cette étude prospective des cas témoins des patients diabétiques de type 2 reconnus et diagnostiqués, et des témoins non diabétiques appariés selon l’âge et le sexe. Parallèlement au bilan biologique classique, une analyse d'un des facteurs de risque du stress oxydatif a été réalisée: baisse de HDL-Cholestérol. L’âge moyen des 30 patients diabétiques (47,77±10,78 ans) était comparable à celui des 30 témoins (48,83±10,73 ans). Une baisse significative du cholestérol-HDL dans le sang était observée chez 100% des diabétiques et 50% des témoins (p=0,0000). L'augmentation du HDL cholestérol permet d’éliminer le mauvais cholestérol en excès en nettoyant les tissus et en ramenant le cholestérol vers le foie. Lors du diabète de type 2 on constate une baisse sanguine sensible du taux de HDL-cholestérol, qui est signe indicateur du stress oxydatif. PMID:25767660

  8. Simulation du fonctionnement de capteurs solaires à air de type tôle et de type absorbeur poreux

    NASA Astrophysics Data System (ADS)

    Fournier, Michel; Maurissen, Yves

    1993-12-01

    The comparison between air-heated insolators, no porous and porous plate, often has been made experimentaly. The behaviour model of these insolators permit generalization of the study in the conditions where each insolator is the most performant. La comparaison des capteurs solaires à air à absorbeur de type tôle et de type poreux a été abordée le plus souvent de façon expérimentale. La modélisation du fonctionnement de ces types de capteur permet de généraliser cette comparaison et de définir les domaines de fonctionnement où un type de capteur se montre plus efficace que l'autre.

  9. Le traumatisme du colon: l'expérience du CHU Hassan II de Fès

    PubMed Central

    Benjelloun, El Bachir; Hafid, Hasnai; Karim, Ibnmajdoub; Ousadden, Abdelmalek; Mazaz, Khalid; Taleb, Kahlid Ait

    2012-01-01

    Introduction Les traumatismes du colon sont associés à un risque majeur de complications septiques et de mortalité. Le but de notre étude est d’évaluer les circonstances, la prise en charge, le suivi et les facteurs pronostic de morbidité postopératoire des malades victimes d'un traumatisme colique. Méthodes Il s'agit d'une étude rétrospective sur une série de 49 patients opérés pour des plaies coliques aux services de chirurgie viscérale du CHU HASSAN II de Fès sur une période de 8 ans de juillet 2003 à juillet 2011. Résultats L’âge moyen de nos patients était de 25ans (16-70) avec une nette prédominance masculine (93.8%). Les plaies coliques secondaires à un traumatisme par arme blanche représentent 85% des cas (42 patients), suivi par les plaies iatrogènes au cours d'une coloscopie chez 6 patients (13%), puis les contusions abdominales chez 1 patient (2%). Les parties du cadre colique les plus touchées étaient le colon transverse chez 19 patients (38%) et le colon descendant chez 12 patients (24, 5%). Le colon sigmoïde était le segment le plus touché au cours d'une coloscopie4/6. Quarante-deux patients (85%) ont eu une suture primaire des plaies coliques, six patients (13%) une diversion fécale et un patient (2%) une résection-anastomose. Deux patients (4%) sont décédés suite à un choc septique. La morbidité globale était de 38,7% dominé essentiellement par l'infection de la paroi chez 14 patients et une péritonite post opératoire chez 3 patients. L'analyse univarié a montré une différence significatif en terme d'infection de la paroi entre le groupe colostomie versus suture simple (50% vs 20,9% p<0,05). L'atteinte du colon gauche et la réalisation d'une colostomie sont associés à un risque plus élevés de complications postopératoires. Conclusion La suture primaire peut être effectuée avec un faible taux de complications postopératoire chez la majorité des patients suite à un traumatisme du colon. PMID

  10. L'íle Crémieu (Jura, France), un plateau calcaire épargné par la tectonique ?

    NASA Astrophysics Data System (ADS)

    Rocher, Muriel; Cushing, Marc; Lemeille, Francis; Baize, Stéphane

    2004-10-01

    The 'Île Crémieu', a plateau of Jurassic limestones located in the southern border of the Bresse and at the Jura front, is generally considered as non-deformed. Quaternary ice sheets and drainage have underlined and cleaned out some fracture planes trending NNE and NW-SE that border and crosscut the 'Île Crémieu'. The analysis of seismic profiles reveals NNE-trending normal faults and NW-SE-trending strike-slip faults, crosscutting the basement to Late Miocene layers. Microtectonic fieldwork shows that these faults exist and were activated during the main Cainozoic tectonic events. To cite this article: M. Rocher et al., C. R. Geoscience 336 (2004).

  11. Méningite à streptocoque du groupe A chez le nouveau né: à propos d'un cas

    PubMed Central

    El Youssi, Hind; Touaoussa, Aziz; Deham, Hanouf; Yahyaoui, Ghita; Mahmoud, Mustapha

    2015-01-01

    Bien qu'une augmentation de l'incidence et de la sévérité des infections invasives au streptocoque du groupe A (SGA) durant ces dernières décades ait été constatée par plusieurs auteurs, les méningites dues à cette bactérie restent exceptionnelles chez le nouveau né et leur physiopathologie est encore mal connue. A travers ce travail nous allons rapporter le cas d'une méningite néonatale à SGA diagnostiquée au sein de notre formation, avec revue de la littérature s'intéressant à ces méningites. PMID:26185565

  12. Volume Measurements of Laser-generated Pits for In Situ Geochronology using KArLE (Potassium-Argon Laser Experiment)

    NASA Technical Reports Server (NTRS)

    French, R. A.; Cohen, B. A.; Miller, J. S.

    2014-01-01

    The Potassium-Argon Laser Experiment( KArLE), is composed of two main instruments: a spectrometer as part of the Laser-Induced Breakdown Spectroscopy (LIBS) method and a Mass Spectrometer (MS). The LIBS laser ablates a sample and creates a plasma cloud, generating a pit in the sample. The LIBS plasma is measured for K abundance in weight percent and the released gas is measured using the MS, which calculates Ar abundance in mols. To relate the K and Ar measurements, total mass of the ablated sample is needed but can be difficult to directly measure. Instead, density and volume are used to calculate mass, where density is calculated based on the elemental composition of the rock (from the emission spectrum) and volume is determined by pit morphology. This study aims to reduce the uncertainty for KArLE by analyzing pit volume relationships in several analog materials and comparing methods of pit volume measurements and their associated uncertainties.

  13. Le fibromatosis colli ou torticolis congénital: son diagnostic et sa prise en charge à propos de deux cas

    PubMed Central

    Tchaou, Mazamaesso; Pegbessou, Plaodezina Essobozou; Sonhaye, Lantam; Ahouanssou, Patricia Yékpé; Amadou, Abdoulatif; Kolou, Beresa; Kama, Lidi Bessi; Garba, Nouhou Mahamadou; Koussema, Lama Kegdigoma Agoda; N'dakéna, Koffi

    2015-01-01

    Le fibromatosis colli (FC) est pseudotumeur rare du muscle sterno-cléido-mastoïdien (SCM), à l'origine d'un torticolis dit congénital chez le nouveau-né ou le nourrisson. Le mécanisme étio-pathogénique de sa survenue est sujet à controverse. Son diagnostic fait appel à l’échographie qui permet de mettre en évidence un épaississement caractéristique du muscle. Nous rapportons deux cas diagnostiqués par l’échographie avec pour un cas une notion de malposition intra-utérine et pour l'autre cas une absence totale de malposition et de traumatisme obstétrical qui pourtant est évoqué comme élément du mécanisme de survenue du FC. PMID:26834927

  14. On your mark, get set, GROW! LePRK2-LAT52 interactions regulate pollen tube growth.

    PubMed

    Johnson, Mark A; Preuss, Daphne

    2003-03-01

    Recent discoveries show that LAT52 and LePRK2, two pollen-specific proteins, interact in what might be an autocrine signaling system. This exciting finding indicates that successful fertilization requires ligand-receptor kinase signals that regulate pollen-tube growth. The stage is now set to identify other components of this pathway and to explore their connections with the many signals exchanged between pollen and pistil. PMID:12663216

  15. Le diverticule de l'urètre féminin: à propos de 18 cas

    PubMed Central

    Statoua, Mouad; El Ghanmi, Jihad; Karmouni, Tarik; El Khader, Khalid; Koutani, Abdellatif; Attya, Ahmed Iben

    2014-01-01

    Le diverticule de l'urètre ou poche sous urétrale est une affection rare, d’étiopathogénie non clairement établie, le diagnostique est clinique confirmé par l'urétrocystographie et le traitement est principalement chirurgicale consistant en une diverticulectomie par voie transvaginale. Nous rapportons l'expérience de notre service dans la prise en charge de cette affection en présentons une étude rétrospective sur une durée de 14 ans (entre 2000 et 2014) où on a pris en charge 18 patientes qui présentait un diverticule de l'urètre, l’âge moyen était de 36 ans, une symptomatologie urinaire ramenait les patientes à consulter où le diagnostic de DU a été posé par examen clinique confirmé en précisant ses caractéristiques en urétrocystographie, la prise en charge était chirurgicale et consistait en une diverticulectomie par voie transvaginale. Les suites post-opératoire était simples, la sonde vésicale retirée en moyenne 5,8 jours après l'intervention, on n'a noté aucune complication chez toute nos patientes, hormis un cas de récidives repris. Devant des troubles mictionnels récidivants de la femme, il est indispensable de rechercher un diverticule uréthral à l'examen clinique. La diverticulectomie transvaginale est l'intervention de choix offrant les meilleurs résultats. PMID:25400845

  16. Enquête entomologique dans le foyer historique de trypanosomose humaine africaine de Bendjé (Gabon)

    PubMed Central

    Kohagne Tongué, L.; Gounoue Kamkuimo, R.; Mengue M’eyi, P.; Kaba, D.; Louis, F.J.; Mimpfoundi, R.

    2011-01-01

    La situation de la maladie du sommeil est très peu connue au Gabon. De nombreux foyers historiques n’ont pas été prospectés depuis plus de 15 ans. Le foyer historique de Bendjé fournit régulièrement quelques cas, dépistés passivement, qui concernent le plus souvent des pêcheurs dont il est a priori difficile de déterminer le lieu probable de contamination du fait de leur grande mobilité au cours de leurs activités. La présence des hommes infectés dans ce foyer historique pourrait favoriser son réveil s’il existe un contact étroit entre les différents éléments potentiellement présents du cycle épidémiologique (homme, vecteur, trypanosome). Afin de vérifier l’existence éventuelle d’un risque trypanosomien dans ce foyer, nous y avons mené une enquête entomologique. Des pièges ont été posés dans des biotopes fréquentés par l’homme et laissés en place pendant quatre jours. Trois espèces de glossines (Glossina palpalis palpalis, G. pallicera newsteadi et G. caliginea) ont été capturées et deux espèces de trypanosomes (Trypanosoma vivax et T. brucei s.l.) identifiées par PCR. Ces résultats suggèrent l’existence d’un cycle de transmission animal. Le contact entre les hommes et les glossines est particulièrement étroit dans tous les types de site prospectés, à l’exception de la mangrove. PMID:22091460

  17. le des hyrates dans la formation de Titan et des satellites réguliers

    NASA Astrophysics Data System (ADS)

    Mousis, O.

    2001-12-01

    Cette these est dediee a l'etude de l'origine de Titan et de son atmosphere. Dans l'hypothese ou la subnebuleuse de Saturne etait geometriquement mince, le modele de disque turbulent utilise, derive des travaux de Dubrulle (1993), est moins dense que le modele de Prinn et Fegley (1981). De ce fait, les conversions de Co en CH4 et de N2 en NH3 ont ete inhibees dans la subnebuleuse, contrairement a ce qui est couramment admis pour interpreter la presence du methane dans l'atmosphere de Titan. C'est pourquoi nous avons developpe un nouveau scenario de la formation de titan, qui tient compte simultanement des contraintes resultant de la chimie de la subnebuleuse et des abondances de CH4, N2 et CH3D mesurees dans l'atmosphere du satellite. Nous faisons l'hypothese que ces gaz proviennent initialement de la vaporisation du nuage presolaire, qui s'effondra et forma le Soleil et son disque environnant. Lors du refroidissement de la nebuleuse, les volatils auraient ete pieges sous formes de clathrates d'hydrates dans les grains, puis dans les planetesimaux qu'ils formerent. Les planetesimaux hydrates a l'origine de la formation de Titan seraient alors des rescapes de l'effondrement hydsrodynamique de la feeding zone de Saturne. Ce scenario a ete applique aux subnebuleuses de Jupiter et d'Uranus, et a apporte un certain nombre de contraintes sur la formation des satellites reguliers de ces planetes. Le temps et la zone de formation des grains cometaires ont egalement ete estimes dans la nebuleuse solaire. Enfin, l'etude experimentale de la temperature de fusion du dihydrate d'ammoniac dans la gamme des hautes pressions a apporte des nouvelles donnees thermodynamiques qui permettront d'ameliorer les modeles de l'interieur de Titan.

  18. SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious RORγ Inhibitor.

    PubMed

    Hirata, Kazuyuki; Kotoku, Masayuki; Seki, Noriyoshi; Maeba, Takaki; Maeda, Katsuya; Hirashima, Shintaro; Sakai, Takayuki; Obika, Shingo; Hori, Akimi; Hase, Yasunori; Yamaguchi, Takayuki; Katsuda, Yoshiaki; Hata, Takahiro; Miyagawa, Naoki; Arita, Kojo; Nomura, Yukihiro; Asahina, Kota; Aratsu, Yusuke; Kamada, Masafumi; Adachi, Tsuyoshi; Noguchi, Masato; Doi, Satoki; Crowe, Paul; Bradley, Erin; Steensma, Ruo; Tao, Haiyan; Fenn, Morgan; Babine, Robert; Li, Xiaolin; Thacher, Scott; Hashimoto, Hiromasa; Shiozaki, Makoto

    2016-01-14

    A novel series of RORγ inhibitors was identified starting with the HTS hit 1. After SAR investigation based on a prospective consideration of two drug-likeness metrics, ligand efficiency (LE) and fraction of sp(3) carbon atoms (Fsp(3)), significant improvement of metabolic stability as well as reduction of CYP inhibition was observed, which finally led to discovery of a selective and orally efficacious RORγ inhibitor 3z. PMID:26819660

  19. Unilateral Le Fort I Osteotomy for Rehabilitating the Large Alveolar Cleft and Vertical Malocclusion With the Distraction Technique.

    PubMed

    Baykul, Timuçin; Aydin, Mustafa Asim; Findik, Yavuz; Esenlik, Elçin

    2016-05-01

    Rehabilitation of the large alveolar clefts with autogenous graft or distraction osteogenesis is one of the most common treatment choices. Depending on the clinical situation such as vertical deficiencies, linear transport of the segment does not always ensure a proper closure of the cleft space. In this report, the authors present a patient in whom large unilateral cleft and vertical alveolar deficiency were closed by unilateral Le Fort I osteotomy and distraction technique using the orthodontic elastics. PMID:27054420

  20. Unreliable Yet Still Replicable: A Comment on LeBel and Paunonen (2011)

    PubMed Central

    De Schryver, Maarten; Hughes, Sean; Rosseel, Yves; De Houwer, Jan

    2016-01-01

    Lebel and Paunonen (2011) highlight that despite their importance and popularity in both theoretical and applied research, many implicit measures continue to be plagued by a persistent and troublesome issue—low reliability. In their paper, they offer a conceptual analysis of the relationship between reliability, power and replicability, and then provide a series of recommendations for researchers interested in using implicit measures in an experimental setting. At the core of their account is the idea that reliability can be equated with statistical power, such that “lower levels of reliability are associated with decreasing probabilities of detecting a statistically significant effect, given one exists in the population” (p. 573). They also take the additional step of equating reliability and replicability. In our commentary, we draw attention to the fact that there is no direct, fixed or one-to-one relation between reliability and power or replicability. More specifically, we argue that when adopting an experimental (rather than a correlational) approach, researchers strive to minimize inter-individual variation, which has a direct impact on sample based reliability estimates. We evaluate the strengths and weaknesses of the LeBel and Paunonen's recommendations and refine them where appropriate. PMID:26793150

  1. L’infection bactérienne chez le patient brûlé

    PubMed Central

    Le Floch, R.; Naux, E.; Arnould, J.F.

    2015-01-01

    Summary La mort d’un patient brûlé est le plus souvent causée par une infection, bactérienne dans la grande majorité des cas. La perte de la barrière cutanée, les dispositifs invasifs et l’immunodépression liée à la brûlure sont trois mécanismes concourant à la survenue de ces infections. Chez un patient inflammatoire, les signes infectieux généraux d’infection sont peu discriminants. Du fait de la gravité des infections chez ce patient, leur prévention est un paramètre essentiel de la prise en charge. En raison des particularités pharmacocinétiques des brûlés, les posologies d’antibiotiques doivent être adaptés et les dosages sanguins doivent être systématiques. A l’heure où les résistances deviennent préoccupantes, les recherches sur les thérapeutiques sur les alternatives thérapeutiques parmi lesquels les inhibiteurs de facteurs de virulence, les peptides antimicrobiens, les polyphénols, l’immunothérapie…) deviennent cruciales. L’une des possibilités thérapeutiques les plus prometteuses semble être la phagothérapie. PMID:27252607

  2. ASTROP2-LE: A Mistuned Aeroelastic Analysis System Based on a Two Dimensional Linearized Euler Solver

    NASA Technical Reports Server (NTRS)

    Reddy, T. S. R.; Srivastava, R.; Mehmed, Oral

    2002-01-01

    An aeroelastic analysis system for flutter and forced response analysis of turbomachines based on a two-dimensional linearized unsteady Euler solver has been developed. The ASTROP2 code, an aeroelastic stability analysis program for turbomachinery, was used as a basis for this development. The ASTROP2 code uses strip theory to couple a two dimensional aerodynamic model with a three dimensional structural model. The code was modified to include forced response capability. The formulation was also modified to include aeroelastic analysis with mistuning. A linearized unsteady Euler solver, LINFLX2D is added to model the unsteady aerodynamics in ASTROP2. By calculating the unsteady aerodynamic loads using LINFLX2D, it is possible to include the effects of transonic flow on flutter and forced response in the analysis. The stability is inferred from an eigenvalue analysis. The revised code, ASTROP2-LE for ASTROP2 code using Linearized Euler aerodynamics, is validated by comparing the predictions with those obtained using linear unsteady aerodynamic solutions.

  3. X-ray detector calibration at CEA/Bruyères-le-Châtel

    NASA Astrophysics Data System (ADS)

    Beck, L.; Stemmler, P.; Ban, G.; Villette, B.; Frotté, V.; Bizeuil, C.; Boutin, J.-Y.; Nazet, C.

    1996-02-01

    At CEA/Bruyères-le-Châtel (Service CEM), there are facilities to calibrate X-ray detectors from 200 eV to 100 keV, with an accuracy of 4% at high energies ( E > 3 keV). The source is the direct radiation from the X-ray tubes [C Kα (277 eV) to Ti KαKβ (4.51/4.93 keV)] or fluorescence emission from secondary targets [Mg Kα (1.25 keV) to U Kα (98 keV)]. In addition, calibrations are carried out with the synchrotron radiation of the Super-ACO storage ring (LURE-Orsay), by selecting the monoenergetic beams with a double crystal monochromator which is tunable between 0.8 and 8 keV. The resolution is better than 1 eV. This last tool is very useful in the study of the absorption edges of the detector compounds (for example, Si K-edge and Ar K-edge). Some examples are presented of results obtained between 1 and 50 keV, with special reference to high flux detectors such as gold photocathodes and silicon avalanche photodiodes. Thick silicon photodiodes (for the high energy range) were also calibrated.

  4. [When medicine appeals to our feelings: Charles de Villers' Le magnétiseur amoureux].

    PubMed

    Moruno, Dolores Martín

    2015-01-01

    This article analyses the representation of affective phenomena brought into play in Charles de Villers' Le magnétiseur amoureux (1787) as it helps to better understand the historical transition from the Galenic conception of the passions of the soul to the cerebral interpretation of emotions. While feelings became the condition of possibility in the occurrence of the therapy, passion is identified as the cause of the young woman's illness, Caroline, who according to the interpretation proposed in this article, suffers from what was identified in the eighteenth century medical tradition as "love melancholy" or "hysteric affection", which were both pathologies that alluded to vapors in order to explain their symptoms. The analysis of the logic of feeling running across Villers' novel impels us to interpret the magnetic fluid in terms of the sympathy created between the two main characters. The ambivalence expressed by Villers between the meaning of "love sentiment" and that of "love passion" allows us to finally understand the somnambulist therapy as erotic knowledge that implies a reflection on love codes in late eighteenth century France. PMID:26403058

  5. Does Le Danois Bank (El Cachucho) influence albacore catches in the Cantabrian Sea?

    NASA Astrophysics Data System (ADS)

    Rodríguez-Cabello, C.; Sánchez, F.; Ortiz de Zárate, V.; Barreiro, S.

    2009-05-01

    This study explores the relationship between a seamount located in the Cantabrian Sea known as Le Danois Bank (El Cachucho fishing ground), the first offshore Marine Protected Area (MPA) in Spain, and the Spanish albacore ( Thunnus alalunga) surface fishery that operates during the summer and autumn months. The geographical distribution of catch per unit effort (CPUEs), expressed by number, showed that August and September were the months with the highest catches in the El Cachucho area, however, annual variability existed. Nominal CPUE series obtained from both logbook data and fishing interviews revealed that higher CPUEs were achieved inside the MPA during some fishing seasons, but there was no consistency in the data, since spatial and temporal variability were shown. The spatial distribution of monthly CPUE data was characterized by means of geostatistical analysis. Albacore schools tended to aggregate in mesoscale patches of similar dimensions but the location of these aggregations was non-stationary both in space and time. This supports the hypothesis that albacore are not randomly spatially distributed, but that they concentrated in certain areas where they find suitable conditions of food availability.

  6. The experimental urban catchment 'Le Marais' in Paris: what lessons can be learned from it?

    NASA Astrophysics Data System (ADS)

    Chebbo, G.; Gromaire, M. C.

    2004-12-01

    An experimental catchment area was set up by CEREVE in the centre of Paris, in order to obtain an accurate description of the pollution caused by urban wet weather flows at different locations within the combined sewer system, and hence to estimate the contribution of runoff, waste water and sewer sediments to the total pollution. The results obtained show a change in quality between the runoff entering the sewer network and the combined storm water flow at the sewer's outlet. In particular, an increase was observed in the concentrations of SS, VSS, COD, BOD 5, Cu and in the settling velocities of particles. The assessment of the contribution of different sources to the pollution showed that the organic layer at water-sediment interface in the sewer is the main source of wet weather flow pollution for suspended solids, volatile solids, particle-bound COD and BOD 5, and copper. For cadmium, lead and zinc, it was shown that roof runoff constitutes the main source of wet weather flow pollution in 'Le Marais' catchment, due to the corrosion of the roofing materials.

  7. Maxillary distraction osteogenesis using Le Fort I osteotomy without intraoperative down-fracture.

    PubMed

    Yamauchi, K; Mitsugi, M; Takahashi, T

    2006-06-01

    The aim of this study is to present a technique for maxillary distraction osteogenesis using Le Fort I osteotomy without down-fracture. Six cleft-related patients suffering from severe midfacial deficiency were treated with maxillary distraction osteogenesis. The RED II system was chosen as the extraoral device and the Leipzig retention plate system to anchor the maxillary segment. Maxillary distraction osteogenesis was successful in all cases. Cephalometric and clinical evaluation after an average follow-up period of 1 year showed stable results with respect to skeletal and dental relationships. The SNA angle increased from 72.3 degrees to 81.4 degrees and the ANB angle increased by 11.0 degrees immediately after removing the distraction device. After 1 year, the sagittal bone gain remained and the SNA angle had decreased by 0.8 degrees . This technique seems to minimize the risk of the surgical procedure and shorten the operation time. It may become an alternative method for the treatment of patients with severe midfacial hypoplasia. PMID:16513321

  8. LeRoy Meisinger, Part I: Biographical Tribute with an Assessment of His Contributions to Meteorology.

    NASA Astrophysics Data System (ADS)

    Lewis, John M.

    1995-01-01

    LeRoy Meisinger was a U.S. Weather Bureau meteorologist and aeronaut who worked vigorously to bring meteorology to the aid of aviation in the post-World War 1 period. He was killed at the age of 29 in a scientific ballooning accident that has been detailed in a companion paper by Lewis and Moore. Meisinger's personality and scientific profile are reconstructed by examination of his oeuvre, which contains research contributions augmented by popular articles in the magazines of the period.Meisinger's personal characteristics were those of a quiet, scholarly man with strong interests in science, music, and art. His experiences as a Signal Corps weather officer during World War 1 inclined him toward a career in meteorology. While stationed at the Fort Omaha Balloon School, he became intrigued with the possibilities of using the tree balloon as a platform for tracking air currents.As a research meteorologist with the U.S. Weather Bureau after the war, Meisinger melded adventurous scientific ballooning with the more painstaking and arduous task of scrutinizing data from the limited upper-air network of kite stations. His principal research contribution was a form of differential analysis that extrapolated surface data to the 1- and 2-km levels by using climatological statistics from the upper-air network. The impressive line of research he pioneered at the bureau came to an immediate and abrupt end with his accidental death in 1924.

  9. Impact of active faulting on the post LGM infill of Le Bourget Lake (western Alps, France)

    NASA Astrophysics Data System (ADS)

    de La Taille, Camille; Jouanne, François; Crouzet, Christian; Beck, Christian; Jomard, Hervé; de Rycker, Koen; Van Daele, Maarten

    2015-11-01

    We have used high resolution seismic imaging to detect and characterize the recent deformation recorded by the Quaternary sediments of Le Bourget Lake. The last glacial episodes (MIS 6a and 2, i.e., Riss and Würm) scoured out an elongated over-deepened basin to more than 300 m below the present lake level and the basin accumulated 150 m of post-LGM to Holocene sediments. The well-stratified character of the infill is locally disturbed by tectonic deformations and gravity reworking. A northern fault zone, in continuation with the left-lateral strike-slip Culoz Fault, is imaged within the Holocene and Late Glacial accumulations. A southern fault zone is also detected, which can be related to the sub-lacustrine continuation of a much smaller fault affecting the Jura alpine foreland: the Col du Chat left lateral strike-slip fault. Different generations of fractures have been identified in the lake, allowing correlation and mapping. In pre-Quaternary substratum, the Culoz Fault has a N 160° orientation. Within the post-LGM sediments, fractures related to the Culoz Fault have an orientation between N135° and 95°. A Cloos model (1932) is thus proposed to explain the observed pattern of lacustrine deformations. The calculated horizontal slip rate for Culoz Fault during Holocene is about 1.3 mm·yr- 1, and for the Col du Chat Fault is around 0.6 mm·yr- 1.

  10. The Portevin-Le Chatelier Effect in the Ni-Based Superalloy IN100

    NASA Astrophysics Data System (ADS)

    Fernandez-Zelaia, Patxi; Adair, Benjamin S.; Barker, Vincent M.; Antolovich, Stephen D.

    2015-12-01

    The Portevin-Le Chatelier (PLC) effect has been studied in the Ni-based superalloy IN100 which is currently used as a disk material in jet engines. A series of tensile tests was carried out at 588 K, 755 K, and 922 K (315 °C, 482 °C, and 649 °C) at plastic strain rates ranging from a low of 6.21 × 10-6 s-1 to a high of 4.92 × 10-2 s-1. The activation energy was determined using the slope of a line on a strain rate/temperature graph which divided the area of the graph into two regions: (1) "PLC behavior observed," and (2) "No PLC behavior observed." A new statistical approach was developed to objectively differentiate between a true PLC effect and experimental uncertainty ( i.e., "noise"). The value of the activation energy was found to be 1.14 eV/atom, which strongly suggests that the rate controlling process was bulk diffusion of C in the lattice. A qualitative model, based on the Orowan equation and slip band dislocation mechanics, was proposed, which unifies the seemingly disparate ideas of the process being controlled by a single atom/dislocation interaction while at the same time exhibiting significant strains during PLC load drops.

  11. Activation Energy Calculations for the Portevin-Le Chatelier Effect in Nimonic 263 Superalloy

    NASA Astrophysics Data System (ADS)

    Han, G. M.; Tian, C. G.; Chu, Z. K.; Cui, C. Y.; Hu, Z. Q.; Sun, X. F.

    2015-10-01

    The Portevin-Le Chatelier (PLC) effect in the Nimonic 263 superalloy was investigated by tensile test in a wide temperature range, from room temperature to 1033 K (760 °C), and at strain rates between 0.1 and 4 × 10-4 s-1. Types A, B, and C serrations were observed depending upon the test temperatures and strain rates. The activation energy ( Q) for serrated flow was determined by employing various methodologies for T < 723 K (450 °C), where a normal PLC effect was observed. The value of Q was found to be independent of the method employed. The average Q value of 70 KJ/mol was found to be in agreement with that for diffusion of substitutional solutes such as Cr and Mo in a Ni matrix by pipe diffusion. At temperatures ranging from 723 K to 923 K (450 °C to 650 °C), type C serrations and an inverse PLC effect were noticed, which may be caused by unlocking process.

  12. Portevin-Le Chatelier effect under cyclic loading: experimental and numerical investigations

    NASA Astrophysics Data System (ADS)

    Mazière, M.; Pujol d'Andrebo, Q.

    2015-10-01

    The Portevin-Le Chatelier (PLC) effect is generally evidenced by the apparition of serrated yielding under monotonic tensile loading conditions. It appears at room temperature in some aluminium alloys, around ? in some steels and in many other metallic materials. This effect is associated with the propagation of bands of plastic deformation in tensile specimens and can in some cases lead to unexpected failures. The PLC effect has been widely simulated under monotonic conditions using finite elements and an appropriate mechanical model able to reproduce serrations and strain localization. The occurrence of serrations can be predicted using an analytical stability analysis. Recently, this serrated yielding has also been observed in specimens made of Cobalt-based superalloy under cyclic loading, after a large number of cycles. The mechanical model has been identified in this case to accurately reproduce this critical number of cycle where serrations appear. The associated apparition of localized bands of deformation in specimens and their influence on its failure has also been investigated using finite element simulations.

  13. Discipline and credibility in the post-war australopithecine controversy: Le Gros Clark versus Zuckerman.

    PubMed

    Richmond, Jesse

    2012-01-01

    Paleoanthropologists and outside commentators have often remarked upon the apparent difficulty of securing shared belief among experts in the science of human evolution. The field has been and continues to be particularly prone to disagreement and even controversy among its practitioners to a degree that sets it apart from other areas of scientific inquiry. The fact that the field lies at the intersection of a number of disciplines may help to explain this predicament. Displays of discipline serve as an important resource for scientists as they work to secure credibility. Where a field of inquiry spans a host of disciplinary approaches, there can be disagreement about the kind of disciplined behavior appropriate to making credible claims about that field's subject matter. A conflict of this sort emerged after WW II over the claim that the australopithecines of South Africa represented a likely ancestral link in the evolution of human beings. W. E. Le Gros Clark, working in the established disciplinary tradition of comparative anatomy, endorsed the claim of ancestry, while Solly Zuckerman, reflecting his recent immersion in war-time operations research, criticized that claim on the grounds that it came without the rigorous quantitative demonstration that he felt was the hallmark of a properly disciplined science. PMID:23272594

  14. Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil

    PubMed Central

    Lara-Silva, Fabiana de Oliveira; Michalsky, Érika Monteiro; Ferreira, Eduardo de Castro; Lopes, Maria Olímpia Garcia; Pinheiro, Aimara da Costa; Fortes-Dias, Consuelo Latorre; Dias, Edelberto Santos

    2014-01-01

    In the present study we surveyed the fauna of phlebotomine sand flies and small mammals in peridomestic areas from a Brazilian municipality where the American cutaneous leishmaniasis (ACL) is endemic. A total of 608 female phlebotomine sand flies were captured during nine months in 2009 and 2010. Seven different species were represented with 60% of them being Lutzomyia intermedia and Lu. whitmani, both incriminated vectors of ACL. Lu. longipalpis, a proven vector of visceral leishmaniasis (VL) was also captured at high proportion (12.8%). Genomic DNA analysis of 136 species-specific pools of female sand flies followed by molecular genotyping showed the presence of Leishmania infantum DNA in two pools of Lu. longipalpis. The same Leishmania species was found in one blood sample from Rattus norvegicus among 119 blood and tissue samples analysed. This is the first report of Le. infantum in R. norvegicus in the Americas and suggests a possible role for this rodent species in the zoonotic cycle of VL. Our study coincided with the reemergence of VL in Governador Valadares. PMID:24707492

  15. Ponction biopsies rénales dans le Service de Néphrologie de Fès: indications et résultats: à propos de 522 cas

    PubMed Central

    Mbarki, Houda; Belghiti, Khadija Alaoui; Harmouch, Taoufiq; Najdi, Adil; Arrayhani, Mohamed; Sqalli, Tarik

    2016-01-01

    L'apport de la ponction biopsie rénale (PBR) dans le diagnostic, le choix thérapeutique et l’évaluation pronostique des néphropathies est considérable. Aucune étude marocaine n'a évalué la pratique et l'apport de la PBR. Notre objectif est d’étudier les indications de la PBR, déterminer la fréquence des maladies rénales identifiées par PBR dans notre région et de faire une confrontation entre les données clinico-biologiques et le diagnostic historique. Notre étude menée entre Janvier 2009 et Décembre 2012, est rétrospective. Nous avons inclus tous les patients du service de Néphrologie du CHU Hassan II de Fès ayant bénéficié d'une biopsie de reins natifs. 522 PBR ont été réalisées. Nous avons exclu 8 biopsies devant le manque de renseignements et avons donc retenu 514. L’âge moyen des patients au moment de la PBR est de 39 ±17 ans (3-82 ans). Le sex ratio est de 0,9. Le syndrome néphrotique est le diagnostic clinique le plus fréquent à tous les âges (58,2%). Les néphropathies glomérulaires représentent 94,2% des maladies rénales diagnostiquées, leur distribution varie selon l’âge des patients. La PBR a confirmé le premier diagnostic suspecté cliniquement dans 40,65% des cas, alors qu'elle a révélé un diagnostic inattendu chez 22,5% d'entre eux. Le diagnostic syndromique permet d'orienter vers la maladie rénale la plus probable et de guider les thérapeutiques urgentes en attendant les résultats de la PBR. Mais il ne peut en aucun remplacer la PBR qui reste le gold standard.

  16. Is an osteotome necessary for pterygomaxillary dysjunction or dysjunction through the tuberosity during Le Fort I osteotomy? A systematic review.

    PubMed

    Breeze, J; Linares, C Verea; Stockton, P

    2016-04-01

    Pterygomaxillary dysjunction with an osteotome is commonly used to mobilise the maxilla during Le Fort I osteotomy, despite the risk of serious complications. Different instruments and positions have been tried, including dysjunction through the tuberosity. Down fracture by digital pressure alone has also been advocated, but to our knowledge has not been widely adopted. We have therefore reviewed published papers to see if there is any clinical or anatomical evidence for the use of osteotomes to mobilise the maxilla vertically during a Le Fort I osteotomy for either pterygomaxillary dysjunction or dysjunction through the tuberosity. We found only one paper that analysed the anatomy of the pterygomaxillary fissure and described small bony bridges and syncondroses across the joint. We found no clinical or anatomical evidence for the use of osteotomes in pterygomaxillary separation or separation through the tuberosity. A large clinical trial on down fracture of the maxilla by digital pressure alone showed no serious complications, and we found no strong evidence to justify the use of osteotomes in pterygomaxillary dysjunction or dysjunction through the tuberosity. We have successfully used digital pressure alone in 138 consecutive Le Fort I osteotomies, and we encourage our colleagues to consider adopting this approach. PMID:26687554

  17. Le système opioïde endogène et l’addiction aux drogues1

    PubMed Central

    Maldonado, Rafael

    2010-01-01

    Résumé L’addiction aux drogues est une maladie psychiatrique chronique qui conduit à d’importantes altérations adaptatives dans les circuits de récompense du cerveau. Plusieurs systèmes de neurotransmission sont impliqués dans ces modifications. Cependant, un des systèmes neurochimiques qui joue un rôle essentiel dans l’addiction est le système opioïde endogène. Les récepteurs opioïdes et les peptides opioïdes endogènes sont très largement présents dans les structures cérébrales qui contrôlent les phénomènes de récompense, en particulier le système mésolimbique. Ces récepteurs et peptides opioïdes participent d’une manière sélective à plusieurs aspects des processus addictifs induits par les opiacés, les cannabinoïdes, les psychostimulants, l’alcool et la nicotine. Cette revue rend compte de l’état actuel des connaissances sur la participation de chaque composante du système opioïde endogène dans les propriétés addictives des différentes drogues. PMID:20176158

  18. Le syndrome de la pince aorto-mésentérique: rare, mais pensez-y

    PubMed Central

    Tidjane, Anisse; Tabeti, Benali; Benmaarouf, Noureddine; Boudjenan, Nabil; Bouziane, Chaouky; Kessai, Nadia

    2014-01-01

    Le syndrome de la pince aorto-mésentérique «SPAM » ou syndrome de Wilkie, est une obstruction duodénale secondaire à une pince anatomiquement acquise qui résulte de la compression du troisième duodénum par l'artère mésentérique supérieure « AMS » en avant, et l'aorte en arrière suite à la disparition du tissu graisseux périvasculaire. Les états de dénutrition avancés en sont souvent la cause, et le SPAM se manifeste cliniquement par des vomissements, des plénitudes et des douleurs post prandiales. Le traitement est médical, mais en cas d’échec la chirurgie s'impose. Nous rapportons un cas de SPAM survenu chez un patient âgé de 78 ans présentant une broncho-pneumopathiechronique obstructive, une démence sénile et une anorexie, consultant pour vomissements répétés remontant à plus d'une semaine. PMID:25018797

  19. LeProT1, a transporter for proline, glycine betaine, and gamma-amino butyric acid in tomato pollen.

    PubMed Central

    Schwacke, R; Grallath, S; Breitkreuz, K E; Stransky, E; Stransky, H; Frommer, W B; Rentsch, D

    1999-01-01

    During maturation, pollen undergoes a period of dehydration accompanied by the accumulation of compatible solutes. Solute import across the pollen plasma membrane, which occurs via proteinaceous transporters, is required to support pollen development and also for subsequent germination and pollen tube growth. Analysis of the free amino acid composition of various tissues in tomato revealed that the proline content in flowers was 60 times higher than in any other organ analyzed. Within the floral organs, proline was confined predominantly to pollen, where it represented >70% of total free amino acids. Uptake experiments demonstrated that mature as well as germinated pollen rapidly take up proline. To identify proline transporters in tomato pollen, we isolated genes homologous to Arabidopsis proline transporters. LeProT1 was specifically expressed both in mature and germinating pollen, as demonstrated by RNA in situ hybridization. Expression in a yeast mutant demonstrated that LeProT1 transports proline and gamma-amino butyric acid with low affinity and glycine betaine with high affinity. Direct uptake and competition studies demonstrate that LeProT1 constitutes a general transporter for compatible solutes. PMID:10072398

  20. Le stérilet migrateur: à propos de deux cas et revue de la littérature

    PubMed Central

    Lachiri, Boutaina; Hafidi, Moulay Rachid; Zazi, Abdelgheni; Fagouri, Houda; Kouach, Jaouad; Rahali, Driss Moussaoui; Dehayni, Mohamed

    2014-01-01

    La pose d'un dispositif intra-utérin constitue un geste courant en pratique gynécologique. Elle n'est cependant pas anodine et la survenue d'une perforation utérine peut être grave. La douleur pelvienne est le principal symptôme révélateur. Quinze pour cent des perforations entraineraient une lésion d'organe de voisinage. Devant une suspicion de stérilet ectopique, l’échographie pelvienne est l'examen de première intention. Si le dispositif intra-utérin n'est pas visualisé, une radiographie d'abdomen sans préparation (ASP) s'impose. Le retrait des dispositifs intra-utérins ectopiques est recommandé. A partir de deux observations rarissimes de migration intra abdominale de stérilet, les auteurs font une revue de la littérature concernant les migrations des dispositifs intra-utérins en intra-abdominale et leurs complications. PMID:25932074