These are representative sample records from Science.gov related to your search topic.
For comprehensive and current results, perform a real-time search at Science.gov.
1

[Immunogenetic aspects of early rheumatoid arthritis].  

PubMed

The study is aimed to investigate the distribution of alleles of HLA-DRB1 gene in patients with early rheumatoid arthritis and healthy individuals in Russian population, and evaluate their significance as molecular genetic markers of rheumatoid arthritis predisposition and protection. The association between alleles of HLA-DRB1 genes, antibodies to cyclic citrullinated peptides and IgM rheumatoid factor was also studied. Low and high resolution HLA-DRB1 genotyping were compared. In the cohort of patients with early rheumatoid arthritis, the alleles of HLA-DRB1 gene were found to be markers of rheumatoid arthritis protection/risk, especially in the homozygous state. They determined production of antibodies to cyclic citrullinated peptides but were not associated with rheumatoid factor IgM levels. These findings support different autoimmune mechanisms of rheumatoid arthritis pathogenesis. PMID:24003720

Guseva, I A; Demidova, N V; Soroka, N E; Novikov, A A; Luchikhina, E L; Aleksandrova, E N; Lukina, G V; Fedorenko, E V; Aronova, E S; Samarkina, E Iu; Boldyreva, M N; Trofimov, D Iu; Karateev, D E; Nasonov, E L

2013-01-01

2

Early treatment of psoriatic arthritis improves prognosis.  

PubMed

Psoriatic arthritis (PsA) is a chronic, autoimmune disease, affecting up to 1% of the adult population and up to 40% of those with psoriasis. There is no universally accepted definition or diagnostic criteria for the disease although the CASPAR classification of PsA is now the most widely used. PsA has a peak age of onset between 35 and 55 years with an equal gender distribution. Around 20% of patients develop PsA before psoriasis, often many years before skin or nail changes. Enthesitis, pain and tenderness at the insertion of any tendon onto the bone, is characteristic and screening for enthesitis should include palpation of the lateral epicondyle of the humerus, the medial condyle of the femur and the achilles tendon insertion. Diagnosis of PsA relies on a detailed history, particularly as many of the manifestations may be mild or transient, and therefore not reported by the patient. There may be a previous, current, or family history of psoriasis. There are no diagnostic blood tests for PsA. The presence of rheumatoid factor or anti-CCP antibodies does not preclude a diagnosis of PsA, but should prompt careful scrutiny of the diagnosis. X-rays of the hands and feet should be performed at baseline for all those with suspected inflammatory arthritis. Features of back pain that suggest an inflammatory cause, rather than a mechanical problem, include the presence of early morning stiffness and pain that is relieved by exercise and exacerbated by rest. Any patient with suspected inflammatory arthritis and a six-week history of painful, swollen joints should be referred for specialist assessment. Patients with PsA have a higher self-rated disease severity than those with psoriasis only and a 60% higher risk of premature mortality than the general population, their life expectancy is estimated to be approximately three years shorter. Aggressive treatment of early stage progressive PsA can substantially improve the long-term prognosis. PMID:25603589

McLaughlin, Maeve; Ostör, Andrew

2014-12-01

3

Is early rheumatoid arthritis the same disease process as late rheumatoid arthritis?  

Microsoft Academic Search

Thoughts on treatment for the early control of synovitis have stimulated research on pathobiological events at the site of inflammation in patients with early rheumatoid arthritis. Several studies have thus been conducted to examine synovial biopsy samples at various stages of the disease. The most important conclusion from these studies is that all features of chronic synovial inflammation can be

Paul P. Tak

2001-01-01

4

Identifying Target Areas of Treatment for Depressed Early Inflammatory Arthritis Patients  

Microsoft Academic Search

Background: The goal of this study was to identify target areas for psychosocial intervention for depressed patients with earlyinflammatory arthritis. Methods:One hundred and sixty-five patients with early inflammatory arthritis (?1 joint with synovitis for ?6 weeks and <1 year with a diagnosis of either rheumatoid or undifferentiated inflammatory arthritis) were referred to the McGill Early Arthritis Registry (McEAR) by their

Patricia L. Dobkin; Marta Filipski; Karl Looper; Orit Schieir; Murray Baron

2008-01-01

5

Arthritis  

MedlinePLUS

... or have trouble moving around, you might have arthritis. Most kinds of arthritis cause pain and swelling in your joints. Joints ... joint can become severely damaged. Some kinds of arthritis can also cause problems in your organs, such ...

6

Arthritis  

MedlinePLUS

What Is Arthritis? You may have heard about arthritis (say: ar- thry -tis), which is a disease that causes swelling and ... their joints ache less. Back Continue Living With Arthritis Kids with JIA can have a lot of ...

7

Arthritis  

MedlinePLUS

... arthritis is often a life-long, progressive disease. Gout Gout is a type of arthritis that usually only ... in the United States, including osteoarthritis, rheumatoid arthritis, gout, lupus, and fibromyalgia. In fact, about half of ...

8

A prospective, clinical and radiological study of early psoriatic arthritis: an early synovitis clinic experience  

Microsoft Academic Search

Objective. To determine the clinical presentation and clinical and radiological outcome of early psoriatic arthritis (PsA) at 1 and 2 yr. Methods. Patients with PsA were assessed at the St. Vincent's University Hospital Early Synovitis Clinic. Standardized clinical and laboratory assessment was performed at presentation and 1- and 2-yr follow-up. Radiographs of the hands and feet were evaluated in chronological

D. Kane; B. Bresnihan; O. FitzGerald

2003-01-01

9

Midcarpal Hemiarthroplasty for Wrist Arthritis: Rationale and Early Results  

PubMed Central

Midcarpal hemiarthroplasty is a novel motion-preserving treatment for radiocarpal arthritis and is an alternative to current procedures that provide pain relief at the expense of wrist biomechanics and natural motion. It is indicated primarily in active patients with a well-preserved distal row and debilitating arthritic symptoms. By resurfacing the proximal carpal row, midcarpal arthroplasty relieves pain while preserving the midcarpal articulation and the anatomic center of wrist rotation. This technique has theoretical advantages when compared with current treatment options (i.e., arthrodesis and total wrist arthroplasty) since it provides coupled wrist motion, preserves radial length, is technically simple, and avoids the inherent risks of nonunion and distal component failure. The KinematX midcarpal hemiarthroplasty has an anatomic design and does not disrupt the integrity of the wrist ligaments. We have implanted this prosthesis in nine patients with promising early results. The indications for surgery were as follows: scapholunate advanced collapse wrist (three), posttraumatic osteoarthritis (three), inflammatory arthritis (two), and Keinböck disease (one). Prospective data has been collected and the results are preliminary given the infancy of the procedure. The mean follow-up was 30.9 weeks (range: 16 to 56 weeks). The mean Mayo wrist score increased from 31.9 preoperatively to 58.8 (p?

Vance, Michael C.; Packer, Greg; Tan, David; Crisco, J.J. Trey; Wolfe, Scott W.

2012-01-01

10

Vitamin D status of patients with early inflammatory arthritis.  

PubMed

The present study aimed to investigate the vitamin D status in patients with early inflammatory arthritis (EIA). We conducted a retrospective study among patients who presented with EIA at the outpatient rheumatology clinic of a tertiary referral center between March 2012 and February 2013. In total, 101 subjects with EIA (?1 swollen joint and symptom duration of ?6 months, not explained by another disease) and 101 healthy controls matched for age, sex, and the month of serum vitamin D measurements were enrolled. Serum 25-hydroxy vitamin D (25-OHD) concentrations were assessed by radioimmunoassay. Vitamin D "deficiency" and "severe deficiency" were defined as serum 25-OHD levels <20 and <10 ng/mL, respectively. Among EIA patients, rheumatoid arthritis (RA) was classified according to the 2010 American College of Rheumatology/European League against Rheumatism criteria. Vitamin D deficiency was highly prevalent among EIA patients, but no significant differences in the frequency of vitamin D deficiency of EIA patients and controls were observed (75.2 vs 65.3 %, p?=?0.106). Additionally, in spring and summer, EIA patients had significantly lower serum 25-OHD concentrations than controls, but the opposite trend was observed in autumn. Among 101 EIA patients, 38 (37.1 %) were classified as having RA. Severe vitamin D deficiency in EIA patients was significantly associated with the higher likelihood of being classified as having RA. In conclusion, the frequency of vitamin D deficiency in EIA patients was comparable to that in controls, but severe vitamin D deficiency was associated with the presence of RA among EIA patients. PMID:24718489

Park, Young-Eun; Kim, Bo-Hyun; Lee, Seung-Geun; Park, Eun-Kyung; Park, Ji-Heh; Lee, Sun-Hee; Kim, Geun-Tae

2015-02-01

11

The Significance of Temminck’s Work on Biogeography: Early Nineteenth Century Natural History in Leiden, The Netherlands  

Microsoft Academic Search

C.J. Temminck, director of the Rijksmuseum van Natuurlijke Historie (now the National Museum of Natural History in Leiden) and a renowned ornithologist, gained his contemporary’s respect thanks\\u000a to the description of many new species and to his detailed monographs on birds. He also published a small number of works\\u000a on biogeography describing the fauna of the Dutch colonies in South

M. Eulàlia Gassó Miracle

2008-01-01

12

Personalized Unicompartmental Knee Implant Treats Early Stage Arthritis While Preserving Bone  

MedlinePLUS Videos and Cool Tools

Personalized Unicompartmental Knee Implant Treats Early Stage Arthritis while Preserving Bone (6:00pm CST) You must have Javascript enabled in your web browser. View Program Transcript Click Here to ...

13

Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis  

Microsoft Academic Search

Objective. Expression and activation of matrix metalloproteinases such as MMP-3 (stromelysin-1) and MMP-1 (collagenase-1) are increased in patients with rheumatoid arthritis (RA). Previous negative reports of their value as predictors of joint damage may be due to the lack of a large longitudinal study of early RA patients. This study evaluated their use in assessing early untreated patients with RA

M. J. Green; A. K. S. Gough; J. Devlin; J. Smith; P. Astin; D. Taylor; P. Emery

2003-01-01

14

Left ventricular function in treatment-naive early rheumatoid arthritis  

PubMed Central

Background: The role of inflammation and anti-cyclic citrullinated peptide antibodies (anti-CCP) in the pathogenesis of cardiovascular disease in early rheumatoid arthritis (RA) remains unclear. Previous studies have suggested that both disease activity and disease duration are associated with atherosclerosis and a higher mortality rate caused primarily by coronary artery disease. Objective: We investigated how disease activity, anti-CCP status and coronary calcium score in treatment-naive early RA impacts left ventricular (LV) systolic function. Methods: Fifty-tree patients (30 women) with mean age 58.3±1.3 years and steroid- and disease-modifying antirheumatic drug (DMARD)-naive early RA were included. Disease activity was scored by the use of the Danish national DANBIO registry (number of swollen joints (NSJ (28)), number of tender joints (NTJ (28)), C-reactive protein (CRP) and Health Assessment Questionnaire (HAQ)). Pain, fatigue, patient and physician global assessment and a composite disease activity score (DAS28-CRP) were assessed by visual analog scales (VAS) 0-100. IgM rheumafactor (IgM-RF) and anti-CCP titers were evaluated by standardized techniques. Coronary calcium score was estimated by computed tomography by calculating the Agaston score. One experienced senior rheumatologist and one experienced cardiologist performed all the clinical assessments as well as all the transthoracic echocardiography (TTE) and coronary CT analysis. Results: Disease activity scores before treatment at baseline were: NSJ (28) 7.1±2.7, NTJ (28) 8.5±3.5, CRP 11.7±12.9 mmol/l, HAQ 0.71±0.6, pain VAS 51.1±23.7, fatigue VAS 49.3±24.9, physician global assessment 54.2±15.0 and DAS28-CRP 4.8±0.7. Twenty-three (43%) patients were IgM-RF positive and 33 (62%) were anti-CCP positive. We found LV systolic function by conventional ejection fraction (EF) to be 54.1±9.2% and to be non-significant correlated to disease activity (CRP: r=0.07, p=0.64; baseline NSJ: r=-0.13, p=0.33; NTJ: r=-0.08, p=0.58; HAQ: r=0.23, p=0.1; pain VAS: r=-0.05, p=0.74; fatigue VAS: r=0.03, p=0,83; physician global assessment: r=-0.09, p=0.54 and DAS28: r=-0.03, p=0.84). However, using a more sensitive measurement of the LV function by global longitudinal systolic strain (GLS), we found a significant correlation: HAQ (r=0.29; p=0.037), patient global assessment by VAS (r=0.35; p=0.011), patient fatigue assessment by VAS (r=0.3; p=0.03) and DAS28-CRP (r=0.28; p=0.043); all corrected for relevant confounders (age, gender, pulse and blood pressure). Furthermore, anti-CCP was highly significantly correlated with GLS (r=-0.44; p=0.001) in univariate analysis. In multivariate analysis, it still remained significantly correlated (p=0.018), after correction for age, gender, pulse, and blood pressure. Using strain analysis of LV function, we found a significant difference in GLS in patients with high values of anti-CCP (titers ?340) compared to patients with anti-CCP (titers <340); (-19.9±2.1% vs. -16.4±2.8%; p=0.0001). For patients with high IgM-RF, results were non-significant. Conclusions: We observed a significant correlation between increased disease activity and cardiac function in treatment-naive early RA. PMID:25006535

Løgstrup, Brian B; Deibjerg, Lone K; Hedemann-Andersen, Agnete; Ellingsen, Torkell

2014-01-01

15

Richard Gill Universiteit Leiden  

E-print Network

Richard Gill Universiteit Leiden Erasmus University 11 december 2009 ! "#$%&%'%#$!()*+),--,!../0123 voor futiliteit http://www.math.leidenuniv.nl/~gill/CCMO.pdf #12;Errors of 1st and 2nd kind (1- or 2- sided), are not enough! Richard Gill Universiteit Leiden Erasmus University 11 december 2009

Gill, Richard D.

16

Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3  

E-print Network

Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor and J.E. Henderson1,3,* 1 J.T.N. Wong Laboratories for Mineralized Tissue Research, 2 Joint Diseases Laboratory, Shriner's Hospital for Children and 3 Centre for Bone and Periodontal Research, McGill University

Buschmann, Michael

17

The comparison of ultrasonographic and scintigraphic findings of early arthritis in revealing rheumatoid arthritis according to criteria of American College of Rheumatology  

Microsoft Academic Search

We aimed to investigate the diagnostic significance of high frequency ultrasonography (USG), comparing the findings in USG,\\u000a bone scintigraphy and clinical stuation. Fifty-one patients who had early symptoms of inflammatory arthritis, but not fulfilling\\u000a the ACR diagnostic criteria for rheumatoid arthritis (RA) were included in this study. They were referred to USG and bone\\u000a scintigraphy for examination of the synovial

Ahmet Ozgul; Evren Yasar; Nuri Arslan; Birol Balaban; M. Ali Taskaynatan; Kutay Tezel; Korhan Baklaci; M. Ali Özgüven; T. Alp Kalyon

2009-01-01

18

Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis  

PubMed Central

Synovial leukocyte apoptosis is inhibited in established rheumatoid arthritis (RA). In contrast, high levels of leukocyte apoptosis are seen in self-limiting crystal arthritis. The phase in the development of RA at which the inhibition of leukocyte apoptosis is first apparent, and the relationship between leukocyte apoptosis in early RA and other early arthritides, has not been defined. We measured synovial fluid leukocyte apoptosis in very early arthritis and related this to clinical outcome. Synovial fluid was obtained at presentation from 81 patients with synovitis of ? 3 months duration. The percentages of apoptotic neutrophils and lymphocytes were assessed on cytospin preparations. Patients were assigned to diagnostic groups after 18 months follow-up. The relationship between leukocyte apoptosis and patient outcome was assessed. Patients with early RA had significantly lower levels of neutrophil apoptosis than patients who developed non-RA persistent arthritis and those with a resolving disease course. Similarly, lymphocyte apoptosis was absent in patients with early RA whereas it was seen in patients with other early arthritides. The inhibition of synovial fluid leukocyte apoptosis in the earliest clinically apparent phase of RA distinguishes this from other early arthritides. The mechanisms for this inhibition may relate to the high levels of anti-apoptotic cytokines found in the early rheumatoid joint (e.g. IL-2, IL-4, IL-15 GMCSF, GCSF). It is likely that this process contributes to an accumulation of leukocytes in the early rheumatoid lesion and is involved in the development of the microenvironment required for persistent RA. PMID:16859518

Raza, Karim; Scheel-Toellner, Dagmar; Lee, Chi-Yeung; Pilling, Darrell; Curnow, S John; Falciani, Francesco; Trevino, Victor; Kumar, Kanta; Assi, Lakhvir K; Lord, Janet M; Gordon, Caroline; Buckley, Christopher D; Salmon, Mike

2006-01-01

19

Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis  

PubMed Central

A better understanding of the initial mechanisms that lead to arthritic disease could facilitate development of improved therapeutic strategies. We characterized the synovial microcirculation of knee joints in susceptible mouse strains undergoing intradermal immunization with bovine collagen II in complete Freund's adjuvant to induce arthritis (i.e. collagen-induced arthritis [CIA]). Susceptible DBA1/J and collagen II T-cell receptor transgenic mice were compared with CIA-resistant FVB/NJ mice. Before onset of clinical symptoms of arthritis, in vivo fluorescence microscopy of knee joints revealed marked leucocyte activation and interaction with the endothelial lining of synovial microvessels. This initial inflammatory cell response correlated with the gene expression profile at this disease stage. The majority of the 655 differentially expressed genes belonged to classes of genes that are involved in cell movement and structure, cell cycle and signal transduction, as well as transcription, protein synthesis and metabolism. However, 24 adhesion molecules and chemokine/cytokine genes were identified, some of which are known to contribute to arthritis (e.g. CD44 and neutrophil cytosolic factor 1) and some of which are novel in this respect (e.g. CC chemokine ligand-27 and IL-13 receptor ?1). Online in vivo data on synovial tissue microcirculation, together with gene expression profiling, emphasize the potential role played by early inflammatory events in the development of arthritis. PMID:15987489

Gierer, Philip; Ibrahim, Saleh; Mittlmeier, Thomas; Koczan, Dirk; Moeller, Steffen; Landes, Jürgen; Gradl, Georg; Vollmar, Brigitte

2005-01-01

20

Tailored approach to early psoriatic arthritis patients: clinical and ultrasonographic predictors for structural joint damage.  

PubMed

This study aims to identify the clinical predictors of arthritis in patients with psoriasis and to evaluate the use of musculoskeletal ultrasonography (US) as a predictor for inflammatory structural progression in psoriatic patients. Measures of association (odds ratio (OR)) were tested, in a prospective, cohort 1-year follow-up study, between structural deterioration and the presence of baseline inflammation, or its persistence. One hundred twenty-six psoriatic patients were prospectively evaluated both clinically and by US at 0, 6, and 12 months for synovitis/ joint damage, enthesitis, and onychopathy. X-ray was performed at 0 and 12 months. One hundred twelve sex and age-matched pasoriatic patients without histories of musculoskeletal symptoms were included as control group. Structural deterioration was observed in 47 % of the 5,292 evaluated joints. Clinical variables associated with arthritis risk: BMI?>?25 (OR?=?1.7), body surface area (OR?=?1.13), family history (OR?=?5.72) and nail involvement (OR?=?2.25). BMI?>?30 was significantly correlated (P?arthritis. Baseline synovial score/PD score???2 was associated with increased risk of structural progression: OR?=?1.98 versus 2.61 versus 2.66 (P?arthritis, large BMI (>25), high percentage of psoriatic body surface area, and nail involvement were significantly associated with early onset psoriatic arthritis. Baseline GS score of ?2, PD score of ?2, presence of enthesitis, enhanced vascularity at enthesitis, higher GUESS score, and onychopathy, all at base line as well as persistent synovitis and enthesitis at 6 months are predictors of progressive early psoriatic arthritis. Regular ultrasonographic monitoring of these patients is mandatory to assess the progression of their arthritis status. PMID:24794490

El Miedany, Yasser; El Gaafary, Maha; Youssef, Sally; Ahmed, Ihab; Nasr, Annie

2015-02-01

21

Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis  

PubMed Central

Background: Raised granzyme B in serum and synovium of patients with rheumatoid arthritis suggests a role for cytotoxic T cells and natural killer cells in the pathogenesis of this disease. Objective: To evaluate serum granzyme B in patients with early arthritis and correlate it with specific diagnosis and clinical indices of disease severity. Methods: 257 patients with inflammatory arthritis for less than one year (46% rheumatoid arthritis, 17% spondyloarthropathy, 37% undifferentiated arthritis) had a prospective clinical, serological, and radiographic evaluation. Granzyme B was measured in initial sera by ELISA. Patients were HLA typed for DR alleles using sequence specific primers. A logistic regression model was used to evaluate the potential prognostic value of serum granzyme B in predicting radiographic erosions after one year of follow up. Results: Granzyme B values were similar in rheumatoid arthritis, spondyloarthropathy, and undifferentiated arthritis. Concentrations were higher in rheumatoid factor (RF) positive patients than in RF negative patients (mean (SD): 3.15 (0.92) v 2.89 (0.71) pg/ml; p<0.05). After one year, erosions were present in 30% of patients in the overall cohort, and in 44% of patients with rheumatoid arthritis. In the entire cohort, serum granzyme B did not predict erosions independently. However, high granzyme B was an independent predictor of early erosions in patients with RF positive rheumatoid arthritis (odds ratio = 4.83 (95% confidence interval, 1.13 to 20.59)) (p<0.05). Conclusions: Granzyme B may be a useful prognostic marker in early rheumatoid arthritis and may provide important clues to the pathogenesis of this disease. PMID:15471892

Goldbach-Mansky, R; Suson, S; Wesley, R; Hack, C; El-Gabalawy, H; Tak, P

2005-01-01

22

Implementation of a treat-to-target strategy in very early rheumatoid arthritis: results of the Dutch Rheumatoid Arthritis Monitoring remission induction cohort study  

Microsoft Academic Search

OBJECTIVE: Clinical remission is the ultimate therapeutic goal in rheumatoid arthritis (RA). Although clinical trials have proven this to be a realistic goal, the concept of targeting at remission has not yet been implemented. The objective of this study was to develop, implement, and evaluate a treat-to-target strategy aimed at achieving remission in very early RA in daily clinical practice.

M. Vermeer; H. H. Kuper; M. Hoekstra; C. J. Haagsma; M. D. Posthumus; H. L. Brus; P. L. van Riel; M. A. van der Laar

2011-01-01

23

Medical, physical and psychological status related to early rheumatoid arthritis  

Microsoft Academic Search

Summary As part of an international European research project, a longitudinal study was started by the end of 1990 in the northern part of The Netherlands. The study concentrated on recently diagnosed RA patients (N=292), i.e., incident cases up to four years. According to the duration of the disease, five groups of patients had been formed. The early influence of

B. Krol; R. Sanderman; T. Suurmeijer; D. Doeglas; M. VAN RIJSWIJK; M. VAN LEEUWEN

1995-01-01

24

Biomarkers predicting a need for intensive treatment in patients with early arthritis.  

PubMed

The heterogeneous nature of rheumatoid arthritis (RA) complicates early recognition and treatment. In recent years, a growing body of evidence has demonstrated that intervention during the window of opportunity can improve the response to treatment and slow- or even stop-irreversible structural changes. Advances in therapy, such as biologic agents, and changing approaches to the disease, such as the treat to target and tight control strategies, have led to better outcomes resulting from personalized treatment to patients with different prognostic markers. The various biomarkers identified either facilitate early diagnosis or make it possible to adjust management to disease activity or poor outcomes. However, no single biomarker can bridge the gap between disease onset and prescription of the first DMARD, and traditional biomarkers do not identify all patients requiring early aggressive treatment. Furthermore, the outcomes of early arthritis cohorts are largely biased by the treatment prescribed to patients; therefore, new challenges arise in the search for prognostic biomarkers. Herein, we discuss the value of traditional and new biomarkers and suggest the need for intensive treatment as a new surrogate marker of poor prognosis that can guide therapeutic decisions in the early stages of RA. PMID:25163741

González-Álvaro, I; Ortiz, A M; Seoane, I V; García-Vicuña, R; Martínez, C; Gomariz, R P

2015-01-01

25

Biomarkers Predicting a Need for Intensive Treatment in Patients with Early Arthritis  

PubMed Central

The heterogeneous nature of rheumatoid arthritis (RA) complicates early recognition and treatment. In recent years, a growing body of evidence has demonstrated that intervention during the window of opportunity can improve the response to treatment and slow—or even stop—irreversible structural changes. Advances in therapy, such as biologic agents, and changing approaches to the disease, such as the treat to target and tight control strategies, have led to better outcomes resulting from personalized treatment to patients with different prognostic markers. The various biomarkers identified either facilitate early diagnosis or make it possible to adjust management to disease activity or poor outcomes. However, no single biomarker can bridge the gap between disease onset and prescription of the first DMARD, and traditional biomarkers do not identify all patients requiring early aggressive treatment. Furthermore, the outcomes of early arthritis cohorts are largely biased by the treatment prescribed to patients; therefore, new challenges arise in the search for prognostic biomarkers. Herein, we discuss the value of traditional and new biomarkers and suggest the need for intensive treatment as a new surrogate marker of poor prognosis that can guide therapeutic decisions in the early stages of RA. PMID:25163741

I, González-Álvaro; A.M, Ortiz; I.V, Seoane; R, García-Vicuña; C, Martínez; R.P, Gomariz

2015-01-01

26

Universiteit Leiden Computer Science  

E-print Network

Universiteit Leiden Computer Science Ranking of Multi-Word Terms Name: Ricardo R.M. Blikman Student of frequently used terms. Terms are groups of one or more words in a specific order. By giving an overview of most frequently used terms in document collections we hope to obtain knowledge about its contents

Emmerich, Michael

27

Early combination disease-modifying antirheumatic drug therapy and tight disease control improve long-term radiologic outcome in patients with early rheumatoid arthritis: the 11-year results of the Finnish Rheumatoid Arthritis Combination Therapy trial  

Microsoft Academic Search

INTRODUCTION: Early treatment of rheumatoid arthritis (RA) has been shown to retard the development of joint damage for a period of up to 5 years. The aim of this study was to evaluate the radiologic progression beyond that time in patients with early RA initially treated with a combination of three disease-modifying antirheumatic drugs (DMARDs) or a single DMARD. METHODS:

Vappu Rantalaiho; Markku Korpela; Leena Laasonen; Hannu Kautiainen; Salme Järvenpää; Pekka Hannonen; Marjatta Leirisalo-Repo; Harri Blåfield; Kari Puolakka; Anna Karjalainen; Timo Möttönen

2010-01-01

28

Role overload, pain and physical dysfunction in early rheumatoid or undifferentiated inflammatory arthritis in Canada  

PubMed Central

Background Inflammatory arthritis impairs participation in societal roles. Role overload arises when the demands by a given role set exceed the resources; time and energy, to carry out the required tasks. The present study examines the association between role overload and disease outcomes in early inflammatory arthritis (EIA). Methods Patients (n?=?104) of 7.61?months mean duration of inflammatory arthritis completed self-report questionnaires on sociodemographics, disease characteristics and role overload. Pain was assessed using the Short Form McGill Pain Questionnaire (MPQ) and physical functioning was measured with the Medical Outcomes Study Short Form 36 (SF-36) physical functioning score. Role overload was measured by the Role Overload Scale. Patients indicated the number of social roles they occupied from a total of the three typical roles; marital, parental and paid work. Results Participants’ mean age was 56?years and 70.2% were female. Role overload was not correlated to the number of social roles, however, it was positively associated with pain (p?=?0.004) and negatively associated with physical functioning (p?=?0.001). On multivariate analysis, role overload was negatively associated with physical functioning after controlling for the relevant sociodemographic variables. Conclusion This study identifies a possible reciprocal relationship between role overload and physical functioning in patients with EIA. PMID:22554167

2012-01-01

29

Magnetic resonance imaging applications in early rheumatoid arthritis diagnosis and management.  

PubMed

Early diagnosis and treatment have been recognized as essential for improving clinical outcomes in patients with rheumatoid arthritis (RA). Magnetic resonance imaging (MRI) is a sensitive modality that can assess both inflammatory and structural lesions. MRI can assist in following the disease course in patients treated with traditional disease-modifying antirheumatic drugs and biological therapies both in the clinic and in research trials. Therefore, it is anticipated that MRI becomes the diagnostic imaging modality of choice in RA clinical trials while remaining a useful tool for clinicians evaluating patients with RA. PMID:22819084

Troum, Orrin M; Pimienta, Olga; Olech, Ewa

2012-05-01

30

Approaches to the treatment of early rheumatoid arthritis with disease-modifying antirheumatic drugs  

PubMed Central

This paper reviews recent approaches to treatment of early rheumatoid arthritis (RA) with disease-modifying antirheumatic drugs (DMARDs). The literature on treatment the early RA published between 1995 and 2007 was accessed through the PubMed database from the National Library of Medicine. Keywords were ‘early rheumatoid arthritis’, ‘disease-modifying antirheumatic drugs’, ‘biologic agents’ and ‘combination therapy’. Only results of trials on human subjects that directly measured the effects of DMARDs or biological agents on clinical, laboratory parameters and radiological progression of early RA were selected. Combination therapy suppresses RA activity and radiological progression more effectively than monotherapy. If better control of RA is evident after 3–6 months of treatment with the combination of DMARDs, one must still decide whether to stop the first DMARD, stop the second, or continue with the combination. Combination therapy biological agents (infliximab, adalimumab) with methotrexate and etanercept therapy alone may induce remission in many patients with early RA. It is a method of choice in patients with an adverse prognosis. The main indications for combination therapy ‘standard’ DMARDs or combination 1 DMARDs with a biological agent are such variables as detection of a shared epitope, increase of concentration of anticyclic citrullinated peptide antibodies, rheumatoid factor, C-reactive protein, 28-joint disease activity score, Sharp score and presence of erosion in joints. The majority of rheumatologists believe that patients with RA should be treated with DMARDs earlier rather than later in the disease process. Further trials should establish the optimal approaches to early RA therapy. PMID:18537958

Sizova, Lyudmila

2008-01-01

31

Early intervention in the treatment of rheumatoid arthritis: focus on tocilizumab  

PubMed Central

Tocilizumab is a fully humanized monoclonal antibody against interleukin-6 receptors that was approved for the treatment of patients with rheumatoid arthritis (RA). Several lines of evidence, obtained both from conventional disease-modifying anti-rheumatic drugs (DMARDs) and tumor necrosis factor (TNF) inhibitors, have supported the concept of “window of opportunity” as showing that these therapies consistently work better in early disease as compared to established RA. This review addresses the question of whether a window of opportunity gained with conventional DMARDs and TNF inhibitors can also be achieved with tocilizumab. To this end, data regarding the use of tocilizumab in early RA patients are summarized. Currently available data suggest that the earlier the treatment with tocilizumab, the better the clinical outcome can be, which may have implications for various aspects of RA treatment strategies. PMID:24179334

Yilmaz, Sedat; Simsek, Ismail

2013-01-01

32

Arthritis Induces Early Bone High Turnover, Structural Degradation and Mechanical Weakness  

PubMed Central

Background We have previously found in the chronic SKG mouse model of arthritis that long standing (5 and 8 months) inflammation directly leads to high collagen bone turnover, disorganization of the collagen network, disturbed bone microstructure and degradation of bone biomechanical properties. The main goal of the present work was to study the effects of the first days of the inflammatory process on the microarchitecture and mechanical properties of bone. Methods Twenty eight Wistar adjuvant-induced arthritis (AIA) rats were monitored during 22 days after disease induction for the inflammatory score, ankle perimeter and body weight. Healthy non-arthritic rats were used as controls for compar-ison. After 22 days of disease progression rats were sacrificed and bone samples were collected for histomorphometrical, energy dispersive X-ray spectroscopical analysis and 3-point bending. Blood samples were also collected for bone turnover markers. Results AIA rats had an increased bone turnover (as inferred from increased P1NP and CTX1, p = 0.0010 and p = 0.0002, respectively) and this was paralleled by a decreased mineral content (calcium p = 0.0046 and phos-phorus p = 0.0046). Histomorphometry showed a lower trabecular thickness (p = 0.0002) and bone volume (p = 0.0003) and higher trabecular sepa-ration (p = 0.0009) in the arthritic group as compared with controls. In addition, bone mechanical tests showed evidence of fragility as depicted by diminished values of yield stress and ultimate fracture point (p = 0.0061 and p = 0.0279, re-spectively) in the arthritic group. Conclusions We have shown in an AIA rat model that arthritis induc-es early bone high turnover, structural degradation, mineral loss and mechanical weak-ness. PMID:25617902

Vidal, Bruno; Cascão, Rita; Vale, Ana Catarina; Cavaleiro, Inês; Vaz, Maria Fátima; Brito, José Américo Almeida; Canhão, Helena; Fonseca, João Eurico

2015-01-01

33

Arthritis severity locus Cia4 is an early regulator of IL-6, IL-1?, and NF-?B activators' expression in pristane-induced arthritis  

PubMed Central

Cia4 is a locus on rat chromosome 7 that regulates disease severity and joint damage in models of rheumatoid arthritis, including pristane-induced arthritis (PIA). To identify molecular processes regulated by Cia4, synovial tissues from MHC-identical DA (severe erosive) and DA.F344(Cia4) congenics (mild nonerosive) rats were collected at preclinical and recent onset stages following the induction of PIA and analyzed for gene expression levels. Il6 levels were significantly higher in DA compared with congenics on day 10 (135-fold) after PIA induction (preclinical stage) and remained increased on days 14 (47.7-fold) and 18 (29.41-fold). Il6 increased before Il1b suggesting that Il6 could be driving Il1b expression and early synovial inflammation; 187 genes had significantly different expression levels and included inflammatory mediators increased in DA such Slpi (10.94-fold), Ccl7 (5.17-fold), and Litaf (2.09-fold). Syk or NF-?B activating and interacting genes, including Cd74 Ccl21, were increased in DA; 59 genes implicated in cancer-related phenotypes were increased in DA. Genes involved in cell metabolism, transport across membranes, and tissue protection such as Dgat1, Dhcr7, and Slc1a1 were increased in DA.F344(Cia4) congenics; 21 genes differentially expressed or expressed in only one of the strains were located within the Cia4 interval and could be the gene accounting for the arthritis effect. In conclusion, the Cia4 interval contains at least one new arthritis gene that regulates early Il6, Il1b expression, and other inflammatory mediators. This gene regulates the expression of cancer genes that could mediate the development of synovial hyperplasia and invasion, and cartilage and bone destruction. PMID:23695883

Brenner, Max; Laragione, Teresina

2013-01-01

34

Can we prevent rapid radiological progression in patients with early rheumatoid arthritis?  

PubMed

The aim of this study is to test the performance of a matrix model to predict rapid radiological progression (RRP) in a study population of early rheumatoid arthritis (RA) or undifferentiated arthritis (UA) patients. A matrix model using baseline CRP, erosion score, autoantibody status, and initial treatment choice to predict RRP (increase ?5 points in Sharp-van der Heijde score (SHS) in 1 year) was derived from the BeSt study where patients with active RA (1987-criteria) were treated with initial monotherapy or combination therapy, aiming at low disease activity. In the IMPROVED study, patients with early RA (2010 criteria) and UA were initially treated with methotrexate and prednisone aiming at remission. A receiver operating characteristics (ROC) curve was used to assess the discriminative value of the model to predict damage progression in the IMPROVED population. Four hundred thirty-one out of 479 patients with RA and 106/122 with UA could be categorized as high, intermediate, low, or very low risk for RRP. One patient, with a very low risk profile, showed RRP. Thirty-two other patients (5 %) showed radiological progression ?0.5 point SHS; none had a high risk profile and 22 had a very low risk profile. The area under the curve (AUC) of the ROC curve was 0.56 (95% CI 0.45; 0.68). A matrix model predicting RRP based on risk factors identified in recent onset active RA according to the 1987-criteria performed poorly in recent onset RA (2010 criteria) and UA. It appears that known risk factors for damage progression lose their impact with early remission steered treatment, so that RRP might be considered a phenomenon of the past. PMID:25431327

Heimans, L; Boer, K V C Wevers-de; Ronday, H K; Collée, G; de Sonnaville, P B J; Grillet, B A M; Huizinga, T W J; Allaart, C F

2015-01-01

35

Matrix-mini-tablets of lornoxicam for targeting early morning peak symptoms of rheumatoid arthritis  

PubMed Central

Objective(s): The aim of present research was to develop matrix-mini-tablets of lornoxicam filled in capsule for targeting early morning peak symptoms of rheumatoid arthritis. Materials and Methods: Matrix-mini-tablets of lornoxicam were prepared by direct compression method using microsomal enzyme dependent and pH-sensitive polymers which were further filled into an empty HPMC capsule. To assess the compatibility, FT-IR and DSC studies for pure drug, polymers and their physical mixture were performed. The formulated batches were subjected to physicochemical studies, estimation of drug content, in vitro drug release, drug release kinetics, and stability studies. Results: When FTIR and DSC studies were performed it was found that there was no interaction between lornoxicam and polymers which used. All the physicochemical properties of prepared matrix-mini-tablets were found to be in normal limits. The percentage of drug content was found to be 99.60±0.07%. Our optimized matrix mini-tablets-filled-capsule formulation F30 released lornoxicam after a lag time of 5.02±0.92 hr, 95.48±0.65 % at the end of 8 hr and 99.90±0.83 % at the end of 12 hr. Stability was also found for this formulation as per the guidelines of International Conference on Harmonisation of Technical Requirements of Pharmaceuticals for Human Use. Conclusion: A novel colon targeted delivery system of lornoxicam was successfully developed by filling matrix-mini-tablets into an empty HPMC capsule shell for targeting early morning peak symptoms of rheumatoid arthritis. PMID:24967065

Mohd, Abdul Hadi; Raghavendra Rao, Nidagurthi Guggilla; Avanapu, Srinivasa Rao

2014-01-01

36

Peer-to-peer mentoring for individuals with early inflammatory arthritis: feasibility pilot  

PubMed Central

Objectives To examine the feasibility and potential benefits of early peer support to improve the health and quality of life of individuals with early inflammatory arthritis (EIA). Design Feasibility study using the 2008 Medical Research Council framework as a theoretical basis. A literature review, environmental scan, and interviews with patients, families and healthcare providers guided the development of peer mentor training sessions and a peer-to-peer mentoring programme. Peer mentors were trained and paired with a mentee to receive (face-to-face or telephone) support over 12?weeks. Setting Two academic teaching hospitals in Toronto, Ontario, Canada. Participants Nine pairs consisting of one peer mentor and one mentee were matched based on factors such as age and work status. Primary outcome measure Mentee outcomes of disease modifying antirheumatic drugs (DMARDs)/biological treatment use, self-efficacy, self-management, health-related quality of life, anxiety, coping efficacy, social support and disease activity were measured using validated tools. Descriptive statistics and effect sizes were calculated to determine clinically important (>0.3) changes. Peer mentor self-efficacy was assessed using a self-efficacy scale. Interviews conducted with participants examined acceptability and feasibility of procedures and outcome measures, as well as perspectives on the value of peer support for individuals with EIA. Themes were identified through constant comparison. Results Mentees experienced improvements in the overall arthritis impact on life, coping efficacy and social support (effect size >0.3). Mentees also perceived emotional, informational, appraisal and instrumental support. Mentors also reported benefits and learnt from mentees’ fortitude and self-management skills. The training was well received by mentors. Their self-efficacy increased significantly after training completion. Participants’ experience of peer support was informed by the unique relationship with their peer. All participants were unequivocal about the need for peer support for individuals with EIA. Conclusions The intervention was well received. Training, peer support programme and outcome measures were demonstrated to be feasible with modifications. Early peer support may augment current rheumatological care. Trial registration number NCT01054963, NCT01054131. PMID:23457326

Sandhu, Sharron; Veinot, Paula; Embuldeniya, Gayathri; Brooks, Sydney; Sale, Joanna; Huang, Sicong; Zhao, Alex; Richards, Dawn; Bell, Mary J

2013-01-01

37

Auranofin improves outcome in early rheumatoid arthritis. Results from a 2-year, double blind placebo controlled study.  

PubMed

The effect of early initiation of auranofin (AF) therapy on outcome measures was studied in a controlled 24-month double blind trial in 138 patients with early rheumatoid arthritis (RA) using an intent to treat approach. Patients were randomized to AF or placebo but in case of insufficient effect or intolerable adverse events, they switched to open disease modifying antirheumatic drug therapy. Patients who started AF fared significantly better in improved joint swelling. Stanford Health Assessment Questionnaire index, Keitel functional test, and mental depression, and furthermore, radiologic progression was significantly retarded. Our results support a disease modifying beneficial effect of AF in early active RA.se PMID:14552308

Borg, G; Allander, E; Lund, B; Berg, E; Brodin, U; Pettersson, H; Trang, L

1988-12-01

38

Early effects of tocilizumab on bone and bone marrow lesions in a collagen-induced arthritis monkey model  

Microsoft Academic Search

To understand the contribution of IL-6\\/IL-6R to subchondral bone and bone marrow abnormality in RA patients and the effects of tocilizumab on those abnormalities, we evaluated early change in a collagen-induced arthritis (CIA) monkey model with or without a single administration of tocilizumab. Six CIA cynomolgus monkeys received tocilizumab and 3 CIA monkeys received vehicle only. Their interphalangeal joints were

Atsuhiko Kato; Saori Matsuo; Hirotake Takai; Yasushi Uchiyama; Masahiko Mihara; Masami Suzuki

2008-01-01

39

MRI in early rheumatoid arthritis: synovitis and bone marrow oedema are independent predictors of subsequent radiographic progression  

Microsoft Academic Search

ObjectivesTo determine whether MRI and conventional (clinical and laboratory) measures of inflammation can predict 3-year radiographic changes measured by the van der Heijde Sharp score in patients with early rheumatoid arthritis (RA).Methods55 patients with RA with disease duration <1 year participated in this 3-year follow-up study. Patients were evaluated at baseline, 3, 6, 12 and 36 months by swollen and

Pernille Bøyesen; Espen A Haavardsholm; Mikkel Østergaard; Désirée van der Heijde; Sølve Sesseng; Tore K Kvien

2011-01-01

40

Aggressive treatment of early rheumatoid arthritis: recognizing the window of opportunity and treating to target goals.  

PubMed

Evidence supports the use of aggressive therapy for patients with early rheumatoid arthritis (RA). Clinical outcomes in patients with early RA can improve with a treat-to-target approach that sets the goal at disease remission. The current selection of antirheumatic therapies, including conventional and biologic disease-modifying antirheumatic drugs (DMARDs), has made disease remission a realistic target for patients with early RA. The challenge is selecting the optimal antirheumatic drug or combination of drugs for initial and subsequent therapy to balance the clinical benefits, risks, and economic considerations. In some cases, the use of biologic agents as part of the treatment regimen has shown superior results compared with conventional DMARDs alone in halting the progression of disease, especially in reducing radiographic damage. However, the use of biologic agents as initial therapy is challenged by cost-effectiveness analyses, which favor the use of conventional DMARDs. The use of biologic agents may be justified in certain patients with poor prognostic factors or those who experience an inadequate response to conventional DMARDs as a means to slow or halt disease progression and its associated disability. In these cases, the higher cost of treatment with biologic agents may be offset by decreased societal costs, such as lost work productivity, and increased health-related quality of life. Further research is needed to understand optimal strategies for balancing costs, benefits, and risks of antirheumatic drugs. Some key questions are (1) when biologic agents are appropriate for initial therapy, and (2) when to conclude that response to conventional DMARDs is inadequate and biologic agents should be initiated. PMID:21517638

Resman-Targoff, Beth H; Cicero, Marco P

2010-11-01

41

A new strategy for the early diagnosis of rheumatoid arthritis: A combined approach  

Microsoft Academic Search

Rheumatoid arthritis [RA] is one of the most common and severe autoimmune rheumatic diseases, diagnosed primarily according to clinical manifestations and radiological reports. For many years, laboratory diagnosis of rheumatoid arthritis has relied on the detection of rheumatoid factor [RF], as established by the ACR criteria. A recent test to detect antibodies towards citrullinated peptides, called the anti-CCP assay, showed

A. Tedesco; D. D'Agostino; I. Soriente; P. Amato; R. Piccoli; P. Sabatini

2009-01-01

42

Early effects of tocilizumab on bone and bone marrow lesions in a collagen-induced arthritis monkey model.  

PubMed

To understand the contribution of IL-6/IL-6R to subchondral bone and bone marrow abnormality in RA patients and the effects of tocilizumab on those abnormalities, we evaluated early change in a collagen-induced arthritis (CIA) monkey model with or without a single administration of tocilizumab. Six CIA cynomolgus monkeys received tocilizumab and 3 CIA monkeys received vehicle only. Their interphalangeal joints were analyzed using HE, silver impregnation (SI), or immunohistochemistry (RANKL) staining. The number of osteoclasts increased in the arthritis control but was suppressed in the tocilizumab-treated animals. Osteoblast/stromal cells of the arthritis control monkeys were of monolayer, while in the tocilizumab-treated monkeys, the cells were multi-layer or differentiated osteoblasts, and the meshwork of the reticulum fibers showed recovery in the SI. Hematopoietic marrow was replaced by interstitial fluid and reticulum fibers were eliminated in the arthritic model but showed recovery in the tocilizumab-treated animals. RANKL showed overproduction with arthritis and suppressed with tocilizumab treatment. The evidence indicates that IL-6/IL-6R is involved in subchondral bone and bone marrow change in RA patients. Tocilizumab treatment recovered changes in the CIA monkeys as a result of the co-differentiation between the osteoclasts and the osteoblast/stramal cells, at least partially through the suppression of RANKL overproduction. PMID:18511040

Kato, Atsuhiko; Matsuo, Saori; Takai, Hirotake; Uchiyama, Yasushi; Mihara, Masahiko; Suzuki, Masami

2008-06-01

43

Altered memory T cell differentiation in patients with early rheumatoid arthritis.  

PubMed

The chronic immune response in rheumatoid arthritis (RA) might be driven by activated Th1 cells without sufficient Th2 cell differentiation to down-modulate inflammation. To test whether disordered memory T cell differentiation contributes to the typical Th1-dominated chronic inflammation in RA we investigated differentiation of resting CD4+ memory T cells in patients with early (6 wk to 12 mo) untreated RA and in age- and sex-matched healthy controls in vitro. No difference in cytokine secretion profiles of freshly isolated memory T cells was detected between patients and controls. A cell culture system was then employed that permitted the differentiation of Th effectors from resting memory T cells by short term priming. Marked differences were found in response to priming. Th2 cells could be induced in all healthy controls by priming with anti-CD28 in the absence of TCR ligation. By contrast, priming under those conditions resulted in Th2 differentiation in only 9 of 24 RA patients. Exogenous IL-4 could overcome the apparent Th2 differentiation defect in seven patients but was without effect in the remaining eight patients. In all patients a marked decrease in IL-2-producing cells and a significant increase in well-differentiated Th1 cells that produced IFN-gamma but not IL-2 were evident after priming with anti-CD3 and anti-CD28. The data suggest that CD4+ memory T cells from patients with early untreated RA manifest an intrinsic abnormality in their ability to differentiate into specific cytokine-producing effector cells that might contribute to the characteristic Th1-dominated chronic (auto)immune inflammation in RA. PMID:10384153

Skapenko, A; Wendler, J; Lipsky, P E; Kalden, J R; Schulze-Koops, H

1999-07-01

44

Relationship between pulse wave velocity and serum YKL-40 level in patients with early rheumatoid arthritis.  

PubMed

Subclinical atherosclerosis has been demonstrated in patients with early rheumatoid arthritis (ERA) without any signs of cardiovascular disease (CVD). The aim of this study was to investigate the relationship between serum YKL-40 level and arterial stiffness in patients with ERA. Forty two patients with ERA and 35 healthy controls with no history or current sign of CVD were included in the study. ERA patients with active disease, defined as DAS28 ? 3.2, and symptoms onset <12 months were recruited. Arterial stiffness was evaluated by carotid-femoral pulse wave velocity (CF-PWV), and the intima-media thickness carotid (IMT-C) was measured by carotid ultrasonography. Serum YKL-40 levels were measured by an enzyme-linked immunoassay method. The mean age was 43.1 ± 5.8 years in ERA patients and 41.0 ± 5.9 years in control group. The CFPWV and IMT-C of the ERA patients were determined significantly higher than the control group (P = .001, P < .001, respectively). YKL-40 levels were significantly elevated in ERA patients than controls (P = .008). The serum levels of YKL-40 in the ERA patients showed a strong correlation with CF-PWV (r = .711, P < .001) and IMT-C (r = .733, P < .001). Multiple linear regression analysis revealed that CF-PWV could be explained by serum YKL-40 levels (adjusted R² = .493, P < .001). We have shown that patients with ERA had increased CF-PWV and serum YKL-40 levels. In addition, there was an association between CF-PWV values and serum YKL-40 levels in patients with ERA. As a result, we believe that serum YKL-40 level and CF-PWV might reflect early atherosclerosis in patients with ERA. PMID:23797781

Turkyilmaz, Aysegul Kucukali; Devrimsel, Gul; Kirbas, Aynur; Cicek, Yuksel; Karkucak, Murat; Capkin, Erhan; Gokmen, Ferhat

2013-11-01

45

Synovial membrane protein expression differs between juvenile idiopathic arthritis subtypes in early disease  

PubMed Central

Introduction Juvenile idiopathic arthritis (JIA) is the most common rheumatological disease of childhood with a prevalence of around 1 in 1,000. Without appropriate treatment it can have devastating consequences including permanent disability from joint destruction and growth deformities. Disease aetiology remains unknown. Investigation of disease pathology at the level of the synovial membrane is required if we want to begin to understand the disease at the molecular and biochemical level. The synovial membrane proteome from early disease-stage, treatment naive JIA patients was compared between polyarticular and oligoarticular subgroups. Methods Protein was extracted from 15 newly diagnosed, treatment naive JIA synovial membrane biopsies and separated by two dimensional fluorescent difference in-gel electrophoresis. Proteins displaying a two-fold or greater change in expression levels between the two subgroups were identified by matrix assisted laser desorption ionization-time of flight mass spectrometry with expression further verified by Western blotting and immunohistochemistry. Results Analysis of variance analysis (P???0.05) revealed 25 protein spots with a two-fold or greater difference in expression levels between polyarticular and oligoarticular patients. Hierarchical cluster analysis with Pearson ranked correlation revealed two distinctive clusters of proteins. Some of the proteins that were differentially expressed included: integrin alpha 2b (P?=?0.04); fibrinogen D fragment (P = 0.005); collagen type VI (P?=?0.03); fibrinogen gamma chain (P?=?0.05) and peroxiredoxin 2 (P?=?0.02). The identified proteins are involved in a number of different processes including platelet activation and the coagulation system. Conclusions The data indicate distinct synovial membrane proteome profiles between JIA subgroups at an early stage in the disease process. The identified proteins also provide insight into differentially perturbed pathways which could influence pathological events at the joint level. PMID:24410838

2014-01-01

46

Arthritis - resources  

MedlinePLUS

Resources - arthritis ... The following organizations provide more information on arthritis : American Academy of Orthopaedic Surgeons - http://orthoinfo.aaos.org/menus/arthritis.cfm Arthritis Foundation - www.arthritis.org National Center for Chronic Disease Prevention ...

47

Universiteit Leiden ICT in Business  

E-print Network

i Universiteit Leiden ICT in Business Living Labs Engaging the end user with Social Media Name be various and this thesis focuses on the potential of Social Media for Living Lab projects. The study will present a model how Social Media could be used in projects, based on literature studies, in depth

Emmerich, Michael

48

Universiteit Leiden ICT in Business  

E-print Network

Universiteit Leiden ICT in Business Ranking of Multi-Word Terms Name: Ricardo R.M. Blikman Student of frequently used terms. Terms are groups of one or more words in a specific order. By giving an overview of most frequently used terms in document collections we hope to obtain knowledge about its contents

Emmerich, Michael

49

PREDICTION OF PERMANENT WORK DISABILITY IN A FOLLOW-UP STUDY OF EARLY RHEUMATOID ARTHRITIS: RESULTS OF A TREE STRUCTURED ANALYSIS USING RECPAM  

Microsoft Academic Search

SUMMARY The objectives of this study are: (a) to determine the occurrence of permanent work disability (PWD) in early rheumatoid arthritis (RA); (b) to identify prognostic groups of patients; (c) to assess the employment rates for these groups over time. Seventy-three gainfully employed consecutive out-patients with early RA (>5 ARA 1958 criteria, disease duration < 12 months) at time one

W. MAU; M. BORNMANN; H. WEBER; H. F. WEIDEMANN; H. HECKER; H. H. Raspef

1996-01-01

50

Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals a high prevalence of erosions at four months after symptom onset  

Microsoft Academic Search

OBJECTIVESTo evaluate the role of magnetic resonance imaging (MRI) of the wrist in detecting early joint damage in patients with rheumatoid arthritis (RA).METHODSMRI was performed on 42 patients with early RA (median symptom duration of four months). Scans were scored separately by two musculoskeletal radiologists using a newly devised scoring system, which was validated. MRI findings were compared with plain

Fiona M McQueen; Neal Stewart; Jeff Crabbe; Elizabeth Robinson; Sue Yeoman; Paul L J Tan; Lachy McLean

1998-01-01

51

Aggressive therapy in patients with early arthritis results in similar outcome compared with conventional care: the STREAM randomized trial  

PubMed Central

Objective. To compare the effects of aggressive tight control therapy and conventional care on radiographic progression and disease activity in patients with early mild inflammatory arthritis. Methods. Patients with two to five swollen joints, Sharp–van der Heijde radiographic score (SHS) <5 and symptom duration ?2 years were randomized between two strategies. Patients with a definite non-RA diagnosis were excluded. The protocol of the aggressive group aimed for remission (DAS?early arthritis of two to five joints, both aggressive tight-control therapy including adalimumab and conventional therapy resulted in remission rates around 50%, low radiographic damage and excellent functional status after 2 years. However, full disease control including radiographic arrest in all patients remains an elusive target even in moderately active early arthritis. Trial registration. Dutch Trial Register, http://www.trialregister.nl/, NTR 144. PMID:22166255

van Eijk, Izhar C.; Nielen, Markus M. J.; van der Horst-Bruinsma, Irene; Tijhuis, Gerard J.; Boers, Maarten; Dijkmans, Ben A. C.

2012-01-01

52

Prediction of erosiveness and rate of development of new erosions in early rheumatoid arthritis  

Microsoft Academic Search

Fifty eight patients suffering from a recent onset of rheumatoid arthritis (RA) were studied. Fifty six patients were followed up for 24 months and two for 18 months. Erosions were detected in 17 patients at the onset and at the end of the follow up period the number of patients with erosions was 44. The erosiveness in the joint groups

T T Möttönen

1988-01-01

53

Holography and Kinect Tom Groentjes, Leiden University  

E-print Network

Holography and Kinect Tom Groentjes, Leiden University January 31, 2013 Albert Einstein: "Reality changing the illusion of the floating object above the mirascope. Keywords Holography, Mirascope, Illusion

Emmerich, Michael

54

Dilemmas of participation in everyday life in early rheumatoid arthritis: a qualitative interview study (The Swedish TIRA Project).  

PubMed

Abstract Purpose: To explore the experiences of today's patients with early rheumatoid arthritis (RA) with respect to dilemmas of everyday life, especially regarding patterns of participation restrictions in valued life activities. Methods: A total of 48 patients, aged 20-63, three years post-RA diagnosis were interviewed using the Critical Incident Technique. Transcribed interviews were condensed into meaningful units describing actions/situations. These descriptions were linked to ICF participation codes according to the International Classification of Functioning, Disability and Health (ICF) linking rules. Results: Dilemmas in everyday life were experienced in domestic life, interpersonal interactions and relationships, community, social and civic life. Most dilemmas were experienced in domestic life, including participation restrictions in, e.g. gardening, repairing houses, shovelling snow, watering pot plants, sewing or walking the dog. Also many dilemmas were experienced related to recreation and leisure within the domain community, social and civic life. The different dilemmas were often related to each other. For instance, dilemmas related to community life were combined with dilemmas within mobility, such as lifting and carrying objects. Conclusions: Participation restrictions in today's RA patients are complex. Our results underline that the health care needs to be aware of the patients' own preferences and goals to support the early multi-professional interventions in clinical practice. Implications of Rehabilitation Today's rheumatoid arthritis (RA) patients experience participation restrictions in activities not included in International Classification of Functioning, Disability and Health (ICF) core set for RA or in traditionally questionnaires with predefined activities. The health care need to be aware of the patients' own preferences and goals to meet the individual needs and optimize the rehabilitation in early RA in clinical practice. PMID:25243767

Sverker, Annette; Ostlund, Gunnel; Thyberg, Mikael; Thyberg, Ingrid; Valtersson, Eva; Björk, Mathilda

2014-09-22

55

Serum levels of osteoprotegerin and receptor activator of nuclear factor -?B ligand in children with early juvenile idiopathic arthritis: a 2-year prospective controlled study  

Microsoft Academic Search

BACKGROUND: The clinical relevance of observations of serum levels of osteoprotegerin (OPG) and receptor activator of nuclear factor -?B ligand (RANKL) in juvenile idiopathic arthritis (JIA) is not clear. To elucidate the potential role of OPG and RANKL in JIA we determined serum levels of OPG and RANKL in patients with early JIA compared to healthy children, and prospectively explored

Gunhild Lien; Thor Ueland; Kristin Godang; Anne M Selvaag; Øystein T Førre; Berit Flatø

2010-01-01

56

Decreased Circulating Visfatin Is Associated with Improved Disease Activity in Early Rheumatoid Arthritis: Data from the PERAC Cohort  

PubMed Central

Objective To evaluate circulating visfatin and its relationship with disease activity and serum lipids in patients with early, treatment-naïve rheumatoid arthritis (RA). Methods Serum visfatin was measured in 40 patients with early RA before and after three months of treatment and in 30 age- and sex-matched healthy individuals. Disease activity was assessed using the Disease Activity Score for 28 joints (DAS28) at baseline and at three and 12 months. Multivariate linear regression analysis was performed to evaluate whether improved disease activity is related to serum visfatin or a change in visfatin level. Results Serum visfatin was significantly elevated in early RA patients compared to healthy controls (1.92±1.17 vs. 1.36±0.93 ng/ml; p?=?0.034) and significantly decreased after three months of treatment (to 0.99±0.67 ng/ml; p<0.001). Circulating visfatin and a change in visfatin level correlated with disease activity and improved disease activity over time, respectively. A decrease in visfatin after three months predicted a DAS28 improvement after 12 months. In addition, decreased serum visfatin was not associated with an improved atherogenic index but was associated with an increase in total cholesterol level. Conclusion A short-term decrease in circulating visfatin may represent an independent predictor of long-term disease activity improvement in patients with early RA. PMID:25068448

Sglunda, Ond?ej; Mann, He?man; Hulejová, Hana; Kuklová, Markéta; Pecha, Ond?ej; Pleštilová, Lenka; Filková, Mária; Pavelka, Karel; Vencovský, Ji?í; Šenolt, Ladislav

2014-01-01

57

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin  

PubMed Central

Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis (RA) by assessing a panel of T cell, macrophage, and stromal cell related cytokines and chemokines in the synovial fluid of patients with early synovitis. Synovial fluid was aspirated from inflamed joints of patients with inflammatory arthritis of duration 3 months or less, whose outcomes were subsequently determined by follow up. For comparison, synovial fluid was aspirated from patients with acute crystal arthritis, established RA and osteoarthritis. Rheumatoid factor activity was blocked in the synovial fluid samples, and a panel of 23 cytokines and chemokines measured using a multiplex based system. Patients with early inflammatory arthritis who subsequently developed RA had a distinct but transient synovial fluid cytokine profile. The levels of a range of T cell, macrophage and stromal cell related cytokines (e.g. IL-2, IL-4, IL-13, IL-17, IL-15, basic fibroblast growth factor and epidermal growth factor) were significantly elevated in these patients within 3 months after symptom onset, as compared with early arthritis patients who did not develop RA. In addition, this profile was no longer present in established RA. In contrast, patients with non-rheumatoid persistent synovitis exhibited elevated levels of interferon-? at initiation. Early synovitis destined to develop into RA is thus characterized by a distinct and transient synovial fluid cytokine profile. The cytokines present in the early rheumatoid lesion suggest that this response is likely to influence the microenvironment required for persistent RA. PMID:15987480

Raza, Karim; Falciani, Francesco; Curnow, S John; Ross, Emma J; Lee, Chi-Yeung; Akbar, Arne N; Lord, Janet M; Gordon, Caroline; Buckley, Christopher D; Salmon, Mike

2005-01-01

58

Associations between HLA-DRB1 , RANK , RANKL , OPG , and IL17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis  

Microsoft Academic Search

We examined associations between human leukocyte antigen DRB1 (HLA-DRB1) shared epitope (SE), receptor activator of nuclear factor-kappaB (RANK), RANK ligand (RANKL), osteoprotegerin (OPG), and interleukin 17 (IL-17) genotypes with age of disease onset and radiographic progression in Japanese patients with early rheumatoid arthritis (RA).\\u000a HLA-DRB1 genotypes were evaluated in 123 patients with early RA (98 female, 25 male) within 1 year

Takefumi Furuya; Masayuki Hakoda; Naomi Ichikawa; Kenshi Higami; Yuki Nanke; Toru Yago; Naoyuki Kamatani; Shigeru Kotake

2007-01-01

59

DIAGNOSTIC VALUE OF ANTI-RA33 ANTIBODY, ANTIKERATIN ANTIBODY, ANTIPERINUCLEAR FACTOR AND ANTINUCLEAR ANTIBODY IN EARLY RHEUMATOID ARTHRITIS: COMPARISON WITH RHEUMATOID FACTOR  

Microsoft Academic Search

SUMMARY The goal of this prospective longitudinal study was to determine the serological profile of early rheumatoid arthritis (RA), and to test whether antikeratin antibody (AKA), antiperinuclear factor (API7), anti-RA33 antibody and antinuclear antibodies (ANA) had an additional diagnostic value when prescribed after rheumatoid factor (RF)-detecting methods. Sixty-nine patients with early polyarthritis suggestive of RA, seen between 1991 and 1993,

C. CORDONNIER; O. MEYER; E. PALAZZO; M. DE BANDT; A. ELIAS; P. NICAISE; T. HAÏM; M. F. KAHN; G. CHATELLIER

1996-01-01

60

Brain Cluster Leiden -InventoryBrain Cluster Leiden -Inventory Inventory of organizations working inInventory of organizations working in  

E-print Network

Brain Cluster Leiden - InventoryBrain Cluster Leiden - Inventory Inventory of organizations working brain Annelieke Hoenderkamp Leiden Bio Science Park foundation in assignment of Municipality of Leiden November 2011 #12;IntroductionIntroduction · The brain is the most complex organ in the human body. Its

Galis, Frietson

61

Infectious Arthritis  

MedlinePLUS

... infected joint One type of infectious arthritis is reactive arthritis. The reaction is to an infection somewhere ... is usually the knee, ankle, or toe. Sometimes, reactive arthritis is set off by an infection in ...

62

Is the disease course of rheumatoid arthritis becoming milder? Time trends since 1985 in an inception cohort of early rheumatoid arthritis  

Microsoft Academic Search

OBJECTIVE: Based on comparisons of short-term cohort studies or cross-sectional samples of patients from different calendar times, it has been suggested that present patients with rheumatoid arthritis (RA) have a milder disease course compared with that of patients in past decades. This study was undertaken to investigate whether the course of disease activity and functional disability in patients with RA

Paco M. J. Welsing; Jaap Fransen

2005-01-01

63

Division of Arthritis & Rheumatic Diseases at Oregon Health & Science University  

E-print Network

Division of Arthritis & Rheumatic Diseases at Oregon Health & Science University Our areas of expertise include: · Osteoarthritis · Rheumatoid Arthritis · Ankylosing Spondylitis · Psoriatic Arthritis · Dermatomyositis · Polymyositis · Early Arthritis · HIV Associated Arthritis · Joint Injections Contact Us Division

Chapman, Michael S.

64

The impact of rheumatoid arthritis on foot function in the early stages of disease: a clinical case series  

PubMed Central

Background Foot involvement occurs early in rheumatoid arthritis but the extent to which this impacts on the structure and function leading to impairment and foot related disability is unknown. The purpose of this study was to compare clinical disease activity, impairment, disability, and foot function in normal and early rheumatoid arthritis (RA) feet using standardised clinical measures and 3D gait analysis. Methods Twelve RA patients with disease duration ?2 years and 12 able-bodied adults matched for age and sex underwent 3D gait analysis to measure foot function. Disease impact was measured using the Leeds Foot impact Scale (LFIS) along with standard clinical measures of disease activity, pain and foot deformity. For this small sample, the mean differences between the groups and associated confidence intervals were calculated using the t distribution Results Moderate-to-high foot impairment and related disability were detected amongst the RA patients. In comparison with age- and sex-matched controls, the patients with early RA walked slower (1.05 m/s Vs 1.30 m/s) and had a longer double-support phase (19.3% Vs 15.8%). In terminal stance, the heel rise angle was reduced in the patients in comparison with normal (-78.9° Vs -85.7°). Medial arch height was lower and peak eversion in stance greater in the RA patients. The peak ankle plantarflexion power profile was lower in the patients in comparison with the controls (3.4 W/kg Vs 4.6 W/kg). Pressure analysis indicated that the RA patients had a reduced lesser toe contact area (7.6 cm2 Vs 8.1 cm2), elevated peak forefoot pressure (672 kPa Vs 553 kPa) and a larger mid-foot contact area (24.6 cm2 Vs 19.4 cm2). Conclusion Analysis detected small but clinically important changes in foot function in a small cohort of RA patients with disease duration <2 years. These were accompanied by active joint disease and impairment and disability. PMID:17184535

Turner, Deborah E; Helliwell, Philip S; Emery, Paul; Woodburn, James

2006-01-01

65

Genetics Home Reference: Factor V Leiden thrombophilia  

MedlinePLUS

... and Families Resources for Health Professionals What glossary definitions help with understanding factor V Leiden thrombophilia? blood ... protein ; pulmonary ; surgery ; thrombophilia ; thrombosis You may find definitions for these and many other terms in the ...

66

Juvenile Arthritis  

MedlinePLUS

... medicine, nursing, dentistry, veterinary medicine, the health care system, and preclinical sciences. Where Can People Find More Information About Juvenile Arthritis? National Institute of Arthritis and ...

67

Prevalence of osteoporosis and osteopenia among African Americans with early rheumatoid arthritis: the impact of ethnic-specific normative data.  

PubMed Central

PURPOSE: To examine the prevalence of osteopenia and/or osteoporosis among African Americans with early rheumatoid arthritis (RA) and to assess the effect of using race/ethnicity-specific normative data. METHODS: Bone mineral density (BMD) of the hip and spine was assessed in African Americans with early RA. To examine the impact of using different normative data on disease classification, we calculated two sets of T scores, the first using sex-matched reference data from Caucasians and the second using data from African Americans. Osteoporosis was defined as a BMD at either site > or =2.5 SD below the young adult mean. Osteopenia was defined as a BMD > or =1 SD and <2.5 SD below this mean. RESULTS: Using Caucasian referent data, 33% (n=48) of patients had osteopenia or worse (n=48, 32.9%) and 5% (n=8) were osteoporotic. With the use of African-American normative data, 55% (n=94) were osteopenic or worse, and 16% (n=27) were osteoporotic. CONCLUSION: African Americans with RA are at risk of osteopenia and/or osteoporosis. Different diagnostic classifications may occur in this population based solely on the normative data used for assessing fracture risk. These results underscore the need for a standardized approach in defining osteopenia and osteoporosis in African Americans. PMID:16173331

Mikuls, Ted R.; Saag, Kenneth G.; Curtis, Jeffrey; Bridges, S. Louis; Alarcon, Graciela S.; Westfall, Andrew O.; Lim, Sam S.; Smith, Edwin A.; Jonas, Beth L.; Moreland, Larry W.

2005-01-01

68

Evolving concepts of rheumatoid arthritis  

Microsoft Academic Search

Rheumatoid arthritis is the most common inflammatory arthritis and is a major cause of disability. It existed in early Native American populations several thousand years ago but might not have appeared in Europe until the 17th century. Early theories on the pathogenesis of rheumatoid arthritis focused on autoantibodies and immune complexes. T-cell-mediated antigen-specific responses, T-cell-independent cytokine networks, and aggressive tumour-like

Gary S. Firestein

2003-01-01

69

Cyclosporin A monotherapy versus cyclosporin A and methotrexate combination therapy in patients with early rheumatoid arthritis: a double blind randomised placebo controlled trial  

Microsoft Academic Search

OBJECTIVE: To compare the efficacy and toxicity of cyclosporin A (CsA) monotherapy with CsA plus methotrexate (MTX) combination therapy in patients with early rheumatoid arthritis (RA). PATIENTS AND METHODS: 120 patients with active RA, rheumatoid factor positive and\\/or erosive, were randomly allocated to receive CsA with MTX (n=60) or CsA with placebo (n=60). Treatment with CsA was started in all

A. H. Gerards; RB Landewe; A. P. A. Prins; GA Bruijn; HS Goei The; RF Laan; B. A. C. Dijkmans

2003-01-01

70

Psoriatic arthritis  

SciTech Connect

This book contains 11 chapters. Some of the titles are: The history and epidemiologic definition of psoriatic arthritis as a distinct entity; Psoriatic arthritis: Further epidemiologic and genetic considerations; The radiologic features of psoriatic arthritis; and Laboratory findings and pathology of psoriatic arthritis.

Gerber, L.H.; Espinoza, L.R.

1985-01-01

71

Early, middle, or late administration of zoledronate alleviates spontaneous nociceptive behavior and restores functional outcomes in a mouse model of CFA-induced arthritis.  

PubMed

This study was performed to evaluate whether early, middle, or late treatment of zoledronate, an approved bisphosphonate that blocks bone resorption, can reduce nociceptive behaviors in a mouse arthritis model. Arthritis was produced by repeated intra-articular knee injections of complete Freund's adjuvant (CFA). A dose-response curve with zoledronate (3, 30, 100, and 300??g/kg, i.p., day 4 to day 25, twice weekly for 3 weeks) was performed, and the most effective dose of zoledronate (100??g/kg, i.p.) was initially administered at different times of disease progression: day 4 (early), day 15 (middle), or day 21 (late) and continued until day 25 after the first CFA injection. Flinching of the injected extremity (spontaneous nociceptive behavior), vertical rearings and horizontal activity (functional outcomes), and knee edema were assessed. Zoledronate improved both functional outcomes and reduced flinching behavior. At day 25, the effect of zoledronate on flinching behavior and vertical rearings was greater in magnitude when it was given early or middle rather than late in the treatment regimen. Chronic zoledronate did not reduce knee edema in CFA-injected mice nor functional outcomes in naïve mice by itself. These results suggest that zoledronate may have a positive effect on arthritis-induced nociception and functional disabilities. PMID:25043808

Morado-Urbina, Carlos Eduardo; Alvarado-Vázquez, Perla Abigail; Montiel-Ruiz, Rosa Mariana; Acosta-González, Rosa Issel; Castañeda-Corral, Gabriela; Jiménez-Andrade, Juan Miguel

2014-11-01

72

Differential diagnosis of rheumatoid and psoriatic arthritis at an early stage in the small hand and foot joints using magnetic resonance imaging.  

PubMed

The 2 major and clinically most important primary inflammatory rheumatic diseases which affect small hand and feet joints are rheumatoid arthritis (RA) and psoriatic arthritis (PsA). The most important initial histopathological feature of RA is synovitis followed by chronic proliferative granulomatous pannus-tissue, which is associated with cartilage and bone destruction. Early inflammatory changes in RA also develop synchronously within the subchondral bone marrow. Enthesitis is the hallmark of SNSA, and is often seen as one of the first radiological manifestations of the diseases. As a rule inflammation within the synovial joints, histologically similar to RA, is not so pronounced. Consequently destructive changes within the synovial joints are much less with the exception of PsA in which pronounced bone destruction may develop (arthritis mutilans). Considerable overlapping in clinical and morphological manifestation of RA and PsA may be present. For evaluation of hand and feet joints and surrounding soft tissue structures in RA and PsA different imaging modalities are used, which include projection radiography, ultrasonography (US), radionuclide techniques and magnetic resonance imaging (MRI). MRI has become the imaging modality of choice for evaluation of arthritis, when conventional radiography is not conclusive. PMID:22833070

Jevtic, V; Lingg, G

2012-06-01

73

magazine van de universiteit leiden AlexAnder rinnooy KAn  

E-print Network

hoger onderwijs. "Leiden kan veel van deze man verwachten." mensen boeien fotograaf MaRtijn de VRies,Hollandse Hoogte,martijn de vries medewerkers aan dit nummer Bernard van lammeren, karina meerman, rupert Parkermagazine van de universiteit leiden AlexAnder rinnooy KAn zomer 2008 en verder: `Leiden moet de

Galis, Frietson

74

Psoriatic Arthritis  

MedlinePLUS

... more severe skin disease is predictive of an increased risk of joint disease. Diagnostics. The similarity between psoriatic arthritis and other inflammatory forms of arthritis can delay an accurate diagnosis, ...

75

Psoriatic Arthritis  

MedlinePLUS

... of patients who have a skin rash called psoriasis. This particular arthritis can affect any joint in ... Psoriatic arthritis can occur in people without skin psoriasis, particularly in those who have relatives with psoriasis. ...

76

Closing the Gap Between Bench and Bedside Research for Early Arthritis Therapies (EARTH)  

PubMed Central

This report summarizes the 2010 AOSSM/NIH (American Orthopaedic Society for Sports Medicine/National Institutes of Health) U13 Post–Joint Injury Osteoarthritis II Conference to include the discussion concerning potential study cohorts, assessment considerations, and research priorities. There was strong consensus and enthusiasm for approaching the development of disease-modifying treatments for osteoarthritis through study of “pre-osteoarthritic” cohorts, particularly human subjects under 30 years of age following acute anterior cruciate ligament injuries. Clinical study of acute treatment strategies initiated within a few days after injury will need development of recruitment pathways and short-term proof-of-concept outcome measures that are specific to the intervention being studied. For example, measures of joint inflammation can be used in short-term prospective randomized controlled trials to determine whether an anti-inflammatory intervention was effective in decreasing early inflammation. These short-term clinical trials will need to be followed by longer-term evaluation of the clinical cohorts for joint and cartilage degeneration to determine if the acute intervention affected later development of osteoarthritis. Research priorities were identified in several disciplines, particularly regarding development and validation of quantitative imaging, biomechanics, and biomarker measures of joint structure, composition, and function that predict the accelerated development of osteoarthritis. Systematic study of posttraumatic osteoarthritis is anticipated to advance understanding and treatment of all forms of osteoarthritis. PMID:21730208

Chu, Constance R.; Beynnon, Bruce D.; Buckwalter, Joseph A.; Garrett, William E.; Katz, Jeffrey N.; Rodeo, Scott A.; Spindler, Kurt P.; Stanton, Robert A.

2011-01-01

77

Internal Report 201212 October 2012 Universiteit Leiden  

E-print Network

to loss of control and regulatory compliance. The negative effect of the risks on the adoption of cloud. The results indicate that regulatory compliance, data protection, data location, loss of governance and data Methods to Reduce The Risks of Cloud Computing Anton den Hoed MASTER'S THESIS Leiden Institute of Advanced

Emmerich, Michael

78

21 CFR 864.7280 - Factor V Leiden DNA mutation detection systems.  

Code of Federal Regulations, 2013 CFR

...2013-04-01 false Factor V Leiden DNA mutation detection systems. 864.7280...Packages § 864.7280 Factor V Leiden DNA mutation detection systems. (a) Identification... Factor V Leiden deoxyribonucleic acid (DNA) mutation detection systems are...

2013-04-01

79

21 CFR 864.7280 - Factor V Leiden DNA mutation detection systems.  

Code of Federal Regulations, 2010 CFR

...2010-04-01 false Factor V Leiden DNA mutation detection systems. 864.7280...Packages § 864.7280 Factor V Leiden DNA mutation detection systems. (a) Identification... Factor V Leiden deoxyribonucleic acid (DNA) mutation detection systems are...

2010-04-01

80

21 CFR 864.7280 - Factor V Leiden DNA mutation detection systems.  

...2014-04-01 false Factor V Leiden DNA mutation detection systems. 864.7280...Packages § 864.7280 Factor V Leiden DNA mutation detection systems. (a) Identification... Factor V Leiden deoxyribonucleic acid (DNA) mutation detection systems are...

2014-04-01

81

21 CFR 864.7280 - Factor V Leiden DNA mutation detection systems.  

Code of Federal Regulations, 2012 CFR

...2012-04-01 false Factor V Leiden DNA mutation detection systems. 864.7280...Packages § 864.7280 Factor V Leiden DNA mutation detection systems. (a) Identification... Factor V Leiden deoxyribonucleic acid (DNA) mutation detection systems are...

2012-04-01

82

21 CFR 864.7280 - Factor V Leiden DNA mutation detection systems.  

Code of Federal Regulations, 2011 CFR

...2011-04-01 false Factor V Leiden DNA mutation detection systems. 864.7280...Packages § 864.7280 Factor V Leiden DNA mutation detection systems. (a) Identification... Factor V Leiden deoxyribonucleic acid (DNA) mutation detection systems are...

2011-04-01

83

Clinical and radiological dissociation of anti-TNF plus methotrexate treatment in early rheumatoid arthritis in routine care: Results from the ABRAB study  

PubMed Central

Background Rheumatoid arthritis (RA) is a chronic autoinflammatory joint disease which leads to the destruction of joints and disability of the patients. Anti-tumour necrosis factor (anti-TNF) drugs can halt radiological progression better than conventional DMARDs even in clinical non-responders. Methods The efficacy of anti-TNF plus methotrexate (MTX) treatment versus MTX monotherapy on clinical and radiological outcomes were compared in early rheumatoid arthritis (RA) patients in clinical practice by retrospective analysis of an observational cohort. 49 early RA patients (group A) on first-line MTX monotherapy and 35 early RA patients (group B) on anti-TNF plus MTX treatment were selected from an observational cohort and evaluated retrospectively focusing on their first twelve months of treatment. Data on disease activity (DAS28) and functional status (HAQ-DI) were collected three monthly. One-yearly radiological progression was calculated according to the van der Heijde modified Sharp method (vdHS). Clinical non-responder patients in both groups were selectively investigated from a radiological point of view. Results Disease activity was decreased and functional status was improved significantly in both groups. One-yearly radiological progression was significantly lower in group B than in group A. The percentage of patients showing radiological non-progression or rapid radiological progression demonstrated a significant advantage for group B patients. In addition non-responder patients in group B showed similar radiological results as responders, while a similar phenomenon was not observed in patients in group A. Conclusions Clinical efficacy within our study was similar for tight-controlled MTX monotherapy as well as for combination treatment with anti-TNF and MTX. However MTX monotherapy was accompanied by more rapid radiological progression and less radiological non-progression. Anti-TNF plus MTX decreased radiological progression even in clinical non-responders supporting the advantage of anti-TNF plus MTX combination in dissociating clinical and radiological effects. PMID:25059769

2014-01-01

84

A rare association of early-onset inclusion body myositis, rheumatoid arthritis and autoimmune thyroiditis: a case report and literature review  

PubMed Central

Summary Sporadic inclusion body myositis (sIBM) is a slowly progressive, red-rimmed vacuolar myopathy leading to muscular atrophy and progressive weakness; it predominantly affects males older than fifty years, and is resistant to immunotherapy. It has been described in association with immuno-mediated thrombocytopenic purpura, multiple sclerosis, connective tissue disorders and, occasionally, rheumatoid arthritis. A 37-year-old man with longstanding rheumatoid arthritis and autoimmune thyroiditis with hypothyroidism was referred to us with slowly progressive, diffuse muscle weakness and wasting, which had initially involved the volar finger flexors, and subsequently also the ankle dorsiflexors and knee extensors. Needle electromyography showed typical myopathic motor unit potentials, fibrillation and positive sharp waves with normal nerve conduction studies. Quadriceps muscle biopsy was suggestive of sIBM. Considering data published in the literature, this case may be classified as an early-onset form. The patient was treated with long-term intravenous immunoglobulin and obtained a substantial stabilization of his muscle strength. PMID:24125563

Clerici, Angelo Maurizio; Bono, Giorgio; Delodovici, Maria Luisa; Azan, Gaetano; Cafasso, Giuseppina; Micieli, Giuseppe

2013-01-01

85

Psoriatic arthritis: Epidemiology, diagnosis, and treatment  

PubMed Central

Our understanding of psoriatic arthritis has evolved as new knowledge of the disease has emerged. However, the exact prevalence of psoriatic arthritis is unknown, and its pathogenesis has not been fully elucidated. Genetic, environmental, and immunologic factors have all been implicated in disease development. Early diagnosis and treatment have become primary objectives in clinical rheumatology. Psoriatic arthritis not only causes functional impairment, but also increases mortality risk of patients. The advent of new therapeutic agents capable of arresting the progression of joint damage is expected. However, early psoriatic arthritis assessment remains limited. The objectives of this article are to outline the epidemiology, diagnosis, and treatment of psoriatic arthritis and to suggest a paradigm for identifying early psoriatic arthritis patients. PMID:25232529

Liu, Jung-Tai; Yeh, Horng-Ming; Liu, Shyun-Yeu; Chen, Kow-Tong

2014-01-01

86

magazine van de universiteit leiden willemijn verloop: idealist  

E-print Network

de vries, edwin walvisch Medewerkers aan dit nummer peter Bekkers, dirk van delft, marjolein van enkmagazine van de universiteit leiden willemijn verloop: idealist najaar 2008 en verder: `Nederland: hofleverancier van Buitenlandse zaken #12;2 leidraad leidraad 3 magazine van de universiteit leiden najaar 2008

Galis, Frietson

87

Magazine van de Universiteit Leiden `ik ben altijd  

E-print Network

Hoogte, Frank de Ruiter, Martijn de Vries, Manon van der Zwaal Medewerkers aan dit nummer BeatrijsMagazine van de Universiteit Leiden `ik ben altijd blijven twijfelen' Bettine Vriesekoop een ander talen in Leiden zomer 2011 #12;leidraad 32 leidraad colofon Leidraad is een uitgave van de directie

Galis, Frietson

88

MAGAZINE VAN DE UNIVERSITEIT LEIDEN ONNO INNEMEE: CABARETIER  

E-print Network

Fie en illustraties rhonald Blommestijn, marc de Haan, mark Horn, HH, Frank de ruiter, martijn de vries`In Leiden werd ik opnieuw geboren' MAGAZINE VAN DE UNIVERSITEIT LEIDEN ONNO INNEMEE: CABARETIER;2 leidraad ColoFon aan dit nummer van leidraad werKten mee: wie beter te vragen voor een column over de

Galis, Frietson

89

Han F. Vermeulen, Early History of Ethnography and Ethnology in the German Enlightenment: Anthropological Discourse in Europe and Asia, 1710-1808. PhD thesis University of Leiden /  

E-print Network

Han F. Vermeulen, Early History of Ethnography and Ethnology in the German Enlightenment, the contexts of the first stage were: absolutism, imperialism, Early Enlightenment; those of the second stage: absolutism, universalism, Late Enlightenment. Geographically, these contexts differed: in the first stage

van den Brink, Jeroen

90

Arthritis: Frequently Asked Questions  

MedlinePLUS

... Program , the Arthritis Foundation Aquatic Program and Enhance Fitness ® and Walk with Ease are all examples of programs designed to help people with arthritis increase their physical activity . For management of specific types of arthritis, refer to Arthritis ...

91

Gonococcal Arthritis  

MedlinePLUS

... sexually active adolescent girls. Two forms of gonococcal arthritis exist: One form involves skin rashes and many joints, usually large joints such as the knee, wrist, and ankle. The second, less common form involves ...

92

Psoriatic arthritis  

MedlinePLUS

... that often occurs with a skin condition called psoriasis . ... inflammatory condition. About 1 in 20 people with psoriasis will develop arthritis with the skin condition. In most cases, psoriasis ...

93

Rheumatoid Arthritis  

MedlinePLUS Videos and Cool Tools

... vertebrae to prevent slippage of the vertebrae. Self-Care Rheumatoid arthritis cannot be cured but it can be managed through medications and self-care. The following are important self-care tips: Exercise ...

94

Psoriatic Arthritis  

MedlinePLUS

Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery ... other parts of your body. Some people with psoriasis have psoriatic arthritis. It causes pain, stiffness, and ...

95

Septic arthritis  

MedlinePLUS

... are caused by bacteria such as Staphylococcus or Streptococcus . Chronic septic arthritis (which is less common) is ... than adults to be infected with Group B streptococcus or Haemophilus influenza , if they have not been ...

96

Arthritis Advice  

MedlinePLUS

... people most often have osteoarthritis, rheumatoid arthritis, or gout. Osteoarthritis (OA) is the most common type of ... heart , muscles, blood vessels, nervous system, and eyes . Gout is one of the most painful kinds of ...

97

Progression and regression of atherosclerosis in APOE3-Leiden transgenic mice: an immunohistochemical study.  

PubMed

Apolipoprotein E3-Leiden (APOE3-Leiden) transgenic mice develop hyperlipidemia and are highly susceptible to diet-induced atherosclerosis. We have studied the progression and regression of atherosclerosis using immunohistochemistry. Female transgenic mice were fed a moderate fat diet to study atherosclerosis over a longer time period. Fatty streaks arose in the intima and consisted of lipid filled macrophages which differed in origin. All macrophages expressed the macrophage scavenger receptor while two thirds expressed sialoadhesin and were positive for an antibody recognizing marginal zone macrophages (MOMA-1). All macrophages were negative for the scavenger receptor MARCO and 50% were positive for CD4. Small fatty streaks contained CD-3 positive T-lymphocytes which were for more than 70% CD4-positive. ICAM-1 was positive both in atherosclerotic and control mice. In early plaques, fibrosis was observed on the luminal and medial site of the foam cells while smooth muscle cells were only observed in the fibrous cap. To study regression, we used a high fat, high cholesterol diet to rapidly induce atherosclerosis (14 weeks). The animals were then fed normal chow. Subsequently, atherosclerosis was assayed over time (4, 8, 16 weeks). Cholesterol levels dropped in 4 weeks to control levels. The animals did not show a significantly decrease in plaque size over time. but the percentage macrophages was significantly smaller in the animals after 4 weeks. In conclusion, the APOE3-Leiden mouse is a useful model to study the progression and regression of atherosclerosis. PMID:10208477

Gijbels, M J; van der Cammen, M; van der Laan, L J; Emeis, J J; Havekes, L M; Hofker, M H; Kraal, G

1999-03-01

98

Psoriatic arthritis: an update.  

PubMed

Advances in our understanding of the pathogenesis of psoriatic arthritis and clinical aspects of the disease justify the present review. Studies have identified common inflammatory pathways related to the innate immune response, such as the IL-12/IL-23 axis, along with numerous genes that affect susceptibility to both diseases and influence phenotypic development. Interest has grown in biomarkers that can be used for early diagnosis or prognosis or to predict joint destruction and the response to treatment. Recent reports describe important differences between the effects of disease-modifying antirheumatic drugs and biologics on the process of new bone formation. Other issues that have been discussed include the need for reliable screening methods, particularly for early detection of oligoarticular arthritis, and for protocols to guide referral to specialists, especially in newly created multidisciplinary practices. PMID:24674606

López-Ferrer, A; Laiz-Alonso, A

2014-12-01

99

Photoacoustic tomography to identify inflammatory arthritis  

NASA Astrophysics Data System (ADS)

Identifying neovascularity (angiogenesis) as an early feature of inflammatory arthritis can help in early accurate diagnosis and treatment monitoring of this disease. Photoacoustic tomography (PAT) is a hybrid imaging modality which relies on intrinsic differences in the optical absorption among the tissues being imaged. Since blood has highly absorbing chromophores including both oxygenated and deoxygenated hemoglobin, PAT holds potential in identifying early angiogenesis associated with inflammatory joint diseases. PAT is used to identify changes in the development of inflammatory arthritis in a rat model. Imaging at two different wavelengths, 1064 nm and 532 nm, on rats revealed that there is a significant signal enhancement in the ankle joints of the arthritis affected rats when compared to the normal control group. Histology images obtained from both the normal and the arthritis affected rats correlated well with the PAT findings. Results support the fact that the emerging PAT could become a new tool for clinical management of inflammatory arthritis.

Rajian, Justin Rajesh; Girish, Gandikota; Wang, Xueding

2012-09-01

100

Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study  

Microsoft Academic Search

OBJECTIVE: Rheumatoid arthritis (RA) is a common, severe, chronic inflammatory joint disease. Since the disease may initially be indistinguishable from other forms of arthritis, early diagnosis can be difficult. Autoantibodies seen in RA can be detected years before clinical symptoms develop. In an inception cohort of patients with recent-onset arthritis, we undertook this study to assess the predictive value of

F. A. van Gaalen; S. P. Linn-Rasker; W. J. W. van Venrooij; B. A. de Jong; F. C. Breedveld; C. L. Verweij; R. E. M. Toes; T. W. J. Huizinga

2004-01-01

101

Livedoid vasculopathy and its association with factor V Leiden mutation.  

PubMed

Livedoid vasculopathy is a rare chronic relapsing disorder characterised by recurrent painful thrombotic and vasculitic ulcers on the legs. We present the cases of two Indian women with livedoid vasculopathy that were found to be associated with an underlying factor V Leiden heterozygous mutation. There were no other thrombotic manifestations, and livedoid vasculopathy was the sole presenting feature of the factor V Leiden mutation, although this could also be coincidental. Initial treatment with high-dose immunosuppressive therapy was suboptimal, and the addition of pentoxifylline and antiplatelet therapy was crucial in achieving disease control and remission. These cases highlight the possible association with an underlying prothrombotic disorder, such as factor V Leiden mutation, in patients with livedoid vasculopathy. Although this association is relatively uncommon, it is more relevant to Indian patients, as the presence of factor V Leiden mutation is highest in this ethnicity as compared to the local Malay and Chinese populations. PMID:23268168

Yong, Angeline Anning; Tan, Audrey Wei Hsia; Giam, Yoke Chin; Tang, Mark Boon Yang

2012-12-01

102

Internal Report 2012-201314 August 2013 Universiteit Leiden  

E-print Network

of channel based service connectors Joost Leuven BACHELOR THESIS Leiden Institute of Advanced Computer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Appendices 13 Appendix A Installing Eclipse 13 Appendix B REO extention 14 Appendix C REO

Emmerich, Michael

103

Factor V Leiden Mutation and PT 20210 Mutation Test  

MedlinePLUS

... Pathol_Lab_Med_Vol%20126_Nov_2002_3.pdf through http://www.access-genetics.com . (2001 January 10, Modified). Coagulation Test Descriptions, Factor V Leiden (Activated Protein C Resistance Pcr Assay) and Prothrombin (G20210A) Gene ...

104

Glucocorticoids in early rheumatoid arthritis: are the benefits of joint-sparing effects offset by the adverse effect of osteoporosis? the effects on bone in the utrecht study and the CAMERA-II study.  

PubMed

This paper reviews the clinical effects on bone of 10 mg of prednisone daily in early rheumatoid arthritis, given for 2 years in the Utrecht Study and in the second CAMERA (Computer- Assisted Management in Early Rheumatoid Arthritis) Study, and addresses the question whether there were joint-sparing effects and whether these were offset by adverse effects, especially osteoporosis. We conclude that a 2-year adjunct treatment with 10 mg of prednisone daily increases the benefits of disease-modifying antirheumatic drug therapy and has joint-sparing properties, even if added to the tight control methotrexate-based strategy aiming for remission. Importantly, with good control of inflammation and adequate use of calcium, vitamin D and bisphosphonates - according to national or international guidelines - steroid-induced osteoporosis is rare over 2 years. PMID:25228126

Jacobs, Johannes W G; Bijlsma, Johannes W J; van Laar, Jacob M

2015-01-01

105

Health Assessment Questionnaire disability progression in early rheumatoid arthritis: Systematic review and analysis of two inception cohorts  

PubMed Central

Objective The Health Assessment Questionnaire is widely used for patients with inflammatory polyarthritis (IP) and its subset, rheumatoid arthritis (RA). In this study, we evaluated the progression of HAQ scores in RA (i) by systematically reviewing the published literature on the methods used to assess changes in functional disability over time and (ii) to study in detail HAQ progression in two large prospective observational studies from the UK. Methods Data from two large inception cohorts, ERAS and NOAR, were studied to determine trajectories of HAQ progression over time by applying latent class growth models (LCGMs) to each dataset separately. Age, sex, baseline DAS28, symptom duration, rheumatoid factor, fulfilment of the 1987 ACR criteria and socio-economic status (SES) were included as potential predictors of HAQ trajectory subgroup membership. Results The literature search identified 49 studies showing that HAQ progression has mainly been based on average changes in the total study population. In the HAQ progression study, a LCGM with four HAQ trajectory subgroups was selected as providing the best fit in both cohorts. In both the cohorts, older age, female sex, longer symptom duration, fulfilment of the 1987 ACR criteria, higher DAS28 and lower SES were associated with increased likelihood of membership of subgroups with worse HAQ progression. Conclusion Four distinct HAQ trajectory subgroups were derived from the ERAS and NOAR cohorts. The fact that the subgroups identified were nearly identical supports their validity. Identifying distinct groups of patients who are at risk of poor functional outcome may help to target therapy to those who are most likely to benefit. PMID:24925692

Norton, Sam; Fu, Bo; Scott, David L.; Deighton, Chris; Symmons, Deborah P.M.; Wailoo, Allan J.; Tosh, Jonathan; Lunt, Mark; Davies, Rebecca; Young, Adam; Verstappen, Suzanne M.M

2014-01-01

106

Arthritis Pathology  

Microsoft Academic Search

The pathologic examination of failed joints, whether natural or artificial, is an indispensable part of the understanding of arthritis, as it is the last, and still best opportunity to determine or verify the correct diagnosis. Accuracy in pathologic diagnosis, based on a firm understanding of the various disease processes, provides reliable data for use in clinical registries, provides an opportunity

Edward F. DiCarlo; Michael J. Klein

107

Grammatical Arthritis.  

ERIC Educational Resources Information Center

Discusses grammatical arthritis (an internal buildup of rules that hinders writing flexibility); four new "rules" (concerning "data is,""none are,""hopefully," and the restrictive "which"); attitudes toward English grammar; how to be a helpful editor; and where to learn about grammar. (SR)

Bush, Don

1994-01-01

108

Reactive arthritis.  

PubMed

Reactive arthritis (ReA) is an immune-mediated seronegative arthritis that belongs to the group of spondyloarthropathies and develops after a gastrointestinal or genitourinary system infection. The condition is considered to be characterized by a triad of symptoms (conjunctivitis, arthritis and urethritis) although a constellation of other manifestations may also be present. ReA is characterized by psoriasiform dermatological manifestations that may resemble those of pustular psoriasis and, similar to guttate psoriasis, is a post-infectious entity. Also, the articular manifestations of the disorder are similar to those of psoriatic arthritis and both conditions show a correlation with HLA-B27. These facts have led several authors to suggest that there is a connection between ReA and psoriasis, listing ReA among the disorders related to psoriasis. However, the pathogenetic mechanism behind the condition is complex and poorly understood. Bacterial antigenicity, the type of host response (i.e. Th1/Th2 imbalance) and various genetic factors (i.e. HLA-B27 etc.) play an important role in the development of the disorder. It is unknown whether all the aforementioned factors are part of a mechanism that could be similar to, or share basic aspects with known psoriasis pathogenesis mechanisms. PMID:25199646

Stavropoulos, P G; Soura, E; Kanelleas, A; Katsambas, A; Antoniou, C

2015-03-01

109

Synovial membrane immunohistology in early-untreated rheumatoid arthritis reveals high expression of catabolic bone markers that is modulated by methotrexate  

PubMed Central

Introduction We aimed to investigate the expression and therapeutic modulation of the receptor activator of the NF-?B ligand (RANKL) system in early-untreated rheumatoid arthritis (RA). Methods In this study, 15 patients with newly diagnosed RA (median symptom duration 7 months) were started on methotrexate (MTX) 20 mg weekly. Synovial biopsies were obtained by needle arthroscopy at baseline and 8 weeks after initiation of therapy. X-rays of the hands and feet were obtained at baseline and 1 year after diagnosis. Immunohistochemistry was performed to detect RANKL, receptor activator of nuclear factor-?B (RANK) and osteoprotegerin (OPG) in the synovial biopsies. The in vitro effect of MTX was tested on RA-derived primary fibroblasts and the osteoblasts-like osteosarcoma cell line (rtPCR, Western blot and ELISA) and in osteoclasts (tartrate-resistant acid phosphatase staining and dentine pit formation assay). Results MTX decreased synovial cellularity as well as RANK expression and the RANKL/OPG ratio. We confirmed this effect by a decrease of the mRNA and protein RANKL/OPG ratio in synovial-derived fibroblasts and osteoblasts-like tumoral cells exposed in vitro to methotrexate. Supernatants from MTX treated osteoblasts-like tumoral cells prevented pre-osteoclast formation in the absence of exogenous RANKL. Furthermore, MTX blocked osteoclastogenesis from peripheral blood mononuclear cells despite the presence of macrophage colony stimulating factor and RANKL, which indicates that MTX directly inhibits osteoclastogenesis. Conclusions The synovial membrane of early-untreated RA is characterized by a high RANKL/OPG ratio that can be reversed by methotrexate. PMID:24295447

2013-01-01

110

Evolution of Direct Costs in the First Years of Rheumatoid Arthritis: Impact of Early versus Late Biologic Initiation - An Economic Analysis Based on the ESPOIR Cohort  

PubMed Central

Objectives To estimate annual direct costs of early RA by resource component in an inception cohort, with reference to four distinct treatment strategies: no disease modifying antirheumatic drugs (DMARDs), synthetic DMARDs only, biologic DMARDs in the first year (‘first-year biologic’, FYB), and biologic DMARDs from the second year after inclusion (‘later-year biologic’, LYB); to determine predictors of total and non-DMARD related costs. Methods The ESPOIR cohort is a French multicentric, prospective study of 813 patients with early arthritis. Data assessing RA-related resource utilisation and disease characteristics were collected at baseline, biannually during the first two years and annually thereafter. Costs predictors were determined by generalised linear mixed analyses. Results Over the 4-year follow-up, mean annual direct total costs per treatment strategy group were €3,612 for all patients and €998, €1,922, €14,791, €8,477 respectively for no DMARDs, synthetic DMARDs only, FYB and LYB users. The main predictors of higher costs were biologic use and higher Health Assessment Questionnaire (HAQ) scores at baseline. Being a biologic user led to a higher total cost (FYB Rate Ratio (RR) 7.22, [95% CI 5.59–9.31]; LYB RR 4.39, [95% CI 3.58–5.39]) compared to non-biologic users. Only LYB increased non-DMARD related costs compared to all other patients by 60%. Conclusions FYB users incurred the highest levels of total costs, while their non-DMARD related costs remained similar to non-biologic users, possibly reflecting better RA control. PMID:24811196

Chevreul, Karine; Haour, Georges; Lucier, Sandy; Harvard, Stephanie; Laroche, Marie-Laure; Mariette, Xavier; Saraux, Alain; Durand-Zaleski, Isabelle; Guillemin, Francis; Fautrel, Bruno

2014-01-01

111

Juvenile Rheumatoid Arthritis  

MedlinePLUS

Juvenile rheumatoid arthritis (JRA) is a type of arthritis that happens in children age 16 or younger. It causes joint swelling, ... reduce swelling and pain. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

112

Forms of Arthritis  

MedlinePLUS

... stiffness, inflammation, swelling and, sometimes, destruction of joints. Gout — a form of arthritis that occurs when uric ... the joints. Some 2.1 million Americans have gout. Lupus — a form of arthritis, like rheumatoid arthritis, ...

113

Calcium pyrophosphate arthritis (Pseudogout)  

MedlinePLUS

Calcium pyrophosphate dihydrate deposition disease; CPPD disease; Acute CPPD arthritis; Pseudogout ... Calcium pyrophosphate arthritis is caused by the collection of salt called calcium pyrophosphate dihydrate (CPPD). The buildup ...

114

Systemic-onset juvenile idiopathic arthritis complicated by early onset amyloidosis in a patient carrying a mutation in the MEFV gene  

Microsoft Academic Search

Systemic juvenile idiopathic arthritis (SJIA) is a disorder characterized by arthritis in children starting before 16 years\\u000a of age associated with daily high fever, persisting for more than 2 weeks, and at least one of the following clinical features:\\u000a evanescent cutaneous rash, lymphadenopathy, serositis or hepatosplenomegaly. SJIA patients carry a significantly higher frequency\\u000a of MEFV mutations, the gene responsible for familial Mediterranean

Luca CantariniOrso; Orso Maria Lucherini; Gabriele Simonini; Mauro Galeazzi; Cosima Tatiana Baldari; Rolando Cimaz

115

Early remission is associated with improved survival in patients with inflammatory polyarthritis: results from the Norfolk Arthritis Register  

PubMed Central

Objectives This study aimed to evaluate whether the early achievement of clinical remission influences overall survival in an inception cohort of patients with inflammatory polyarthritis (IP). Methods Consecutive early IP patients, recruited to a primary care based inception cohort from 1990 to 1994 and from 2000 to 2004 were eligible for this study. Remission was defined as absence of clinically detectable joint inflammation on a 51-joint count. In sensitivity analyses, less stringent definitions of remission were used, based on 28-joint counts. Remission was assessed at 1, 2 and 3?years after baseline. All patients were flagged with the national death register. Censoring was set at 1 May 2011. The effect of remission on mortality was analysed using the Cox proportional hazard regression model, and presented as HRs and 95% CIs. Results A total of 1251 patients were included in the analyses. Having been in remission at least once within the first 3?years of follow-up was associated with a significantly lower risk of death: HR 0.72 (95% CI 0.55 to 0.94). Patients who were in remission 1?year after the baseline assessments and had persistent remission over time had the greatest reduction in mortality risk compared with patients who never achieved remission within the first 3?years of follow-up: HR 0.58 (95% CI 0.37 to 0.91). Remission according to less stringent definitions was associated with progressively lower protective effect. Conclusions Early and sustained remission is associated with decreased all-cause mortality in patients with IP. This result supports clinical remission as the target in the management of IP. PMID:23749581

Scirè, Carlo A; Lunt, Mark; Marshall, Tarnya; Symmons, Deborah P M; Verstappen, Suzanne M M

2014-01-01

116

Subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis.  

PubMed

A set of 200 patients with early onset pauciarticular juvenile chronic arthritis (EOPA-JCA) from Munich (165) and Prague (35) was investigated for the subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14. In addition, the relationship of DRB1, DQA1, DQB1 and DPB1 alleles with iridocyclitis in patients with EOPA-JCA was investigated. Subtyping for DRB1*03 was not informative, as all DR3 positive patients and all except one of the controls possessed DRB1*0301. Thus, the role of DRB1*0302 could not be assessed. The subtypes for DRB1*12, *13, and *14 did not reveal any statistically significant difference between patients and controls. In contrast, the subtype DRB1*1104 was the one most strongly associated with EOPA-JCA (chi 2 31.2, p value < 10(-6)). It appears that the subtype DRB1*1103 may also be associated with EOPA-JCA. The association of EOPA-JCA with DR8 is almost exclusively due to the subtype *0801. For the other alleles *0802, *0803, and *0804 there is no evidence for or against involvement in JCA. The analysis of iridocyclitis in EOPA-JCA revealed that DRB1*1104 is not more frequent in patients with eye disease than in patients without eye disease. The presence of DRB1*01 appears to convey some protective effect against the occurrence of iridiocylitis in EOPA-JCA, as had been previously observed by Melin-Aldana et al. PMID:7955632

Haas, J P; Truckenbrodt, H; Paul, C; Hoza, J; Scholz, S; Albert, E D

1994-01-01

117

Rheumatoid factor and anti-citrullinated protein antibody positivity, but not level, are associated with increased mortality in patients with rheumatoid arthritis: results from two large independent cohorts.  

PubMed

IntroductionTo investigate rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) status and levels as predictors of mortality in two large cohorts of patients with early inflammatory arthritis (EIA).MethodsData from the Norfolk Arthritis Register (NOAR) and Leiden Early Arthritis Clinic (EAC) cohorts were used. At baseline, patients had demographic data and smoking status recorded; RF, ACPA and inflammatory markers were measured in the local laboratories. Patients were flagged with national death registers until death or censor date. Antibody status was stratified as negative, low or high positive by RF and ACPA levels individually. In addition, patients were grouped as seronegative, RF positive, ACPA positive or double antibody (RF and ACPA) positive. Cox regression models explored associations between antibody status and mortality adjusting for age, sex, smoking status, inflammatory markers and year of enrolment.Results4962 (NOAR:3053, EAC:1909) patients were included, 64% were female. Median age at onset was 56 (NOAR) and 54 (EAC) years. 35% and 42% of patients were ACPA/RF positive in NOAR and EAC respectively. When antibody status was stratified as negative, low or high positive, there were no consistent findings between the two cohorts. Double antibody positivity was associated with excess mortality in both cohorts compared to seronegative patients: NOAR and EAC respective adjusted HR (95% CI): 1.35 (1.09-1.68) and 1.58 (1.16-2.15).ConclusionsPatients with EIA who are seropositive for both RF and ACPA have increased mortality compared to those who are single positive or seronegative. Antibody level in seropositive patients was not consistently associated with excess mortality. PMID:25471696

Humphreys, Jennifer H; van Nies, Jessica; Chipping, Jackie; Marshall, Tarnya; Mil, Annette; Symmons, Deborah; Verstappen, Suzanne

2014-12-01

118

Reactive arthritis or chronic infectious arthritis?  

PubMed Central

Microbes reach the synovial cavity either directly during bacteraemia or by transport within lymphoid cells or monocytes. This may stimulate the immune system excessively, triggering arthritis. Some forms of ReA correspond to slow infectious arthritis due to the persistence of microbes and some to an infection triggered arthritis linked to an extra-articular site of infection. PMID:12079895

Sibilia, J; Limbach, F

2002-01-01

119

Factor V Leiden and FII 20210 testing in thromboembolic disorders.  

PubMed

Factor V Leiden and prothrombin (F2) c.20210G>A mutation detection are very important in order to define the increased relative risk for venous thromboembolism in selected patients. Use of DNA-based methods to detect both mutations has become widely available in clinical diagnostic laboratories, including fluorescence-based quantitative real-time PCR (qPCR). The latter is a rapid, simple, robust and reliable method to identify genotypes of interest. There are several chemistries used for qPCR; this article describes their principles and applicability for Factor V Leiden and prothrombin (F2) c.20210G>A mutation detection. PMID:21091236

Paji?, Tadej

2010-12-01

120

Comparing Five Year Out-Come in Two Cohorts of Patients with Early Rheumatoid Arthritis – A BARFOT Study  

PubMed Central

The objective of the study was to compare disease characteristics over the first 5 years of disease in patients with RA, with disease onset in 1990s and 2000s, respectively. Methods : All 2235 patients with early RA (disease duration ?12 months) were recruited from the BARFOT prospective observational study. These patients were divided into group 1 included 1992 to 1999 (N=1084, 66% women) and group 2 included 2000 to 2006 (N=1151, 69% women). Disease Activity Score (DAS28), VAS pain and Health Assessment Questionnaire (HAQ) were assessed during 5 years. Remission was defined as DAS28 <2.6. Results : At inclusion, both women and men in group 2 had higher mean DAS28 (SD) than group 1, 5.42 (1.22) vs 5.26 (1.19), p=0.004 and 5.28 (1.22) vs 5.00 (1.27), p=0.004, respectively, mainly dependant on pain and not on inflammatory related measures. Over time DAS28 decreased and was in both genders, from 6 months to the 5-year follow-up, significantly lower in group 2. At 5-year, both women and men in group 2 had higher rate of remission than women and men in group 1. However, despite reduction of VAS pain and HAQ there were no differences in pain and HAQ between groups at any time point. Conclusion : Patients included in the 2000s achieved higher frequency of remission at the 5 year follow-up compared with those included in the 1990s, suggested to reflect the more active medical treatment. Interestingly, however, improvement in pain and HAQ did not differ between the two patient cohorts.

Andersson, Maria L.E; Forslind, Kristina; Hafström, Ingiäld

2015-01-01

121

My Treatment Approach to Rheumatoid Arthritis  

PubMed Central

The past decade has brought important advances in the understanding of rheumatoid arthritis and its management and treatment. New classification criteria for rheumatoid arthritis, better definitions of treatment outcome and remission, and the introduction of biologic response-modifying drugs designed to inhibit the inflammatory process have greatly altered the approach to managing this disease. More aggressive management of rheumatoid arthritis early after diagnosis and throughout the course of the disease has resulted in improvement in patient functioning and quality of life, reduction in comorbid conditions, and enhanced survival. PMID:22766086

Davis, John M.; Matteson, Eric L.

2012-01-01

122

VN Movie Recommender Kerem Denizmen (0364452), University of Leiden  

E-print Network

VN Movie Recommender Kerem Denizmen (0364452), University of Leiden September 30, 2009 #12;Contents . . . . . . . . . . . . . . . . . . 11 3.4 Movie attributes . . . . . . . . . . . . . . . . . . . . . . . . . 11 3.5 Determining . . . . . . . . . . . . . . . . . . . 13 3.5.2 Selection of weight values . . . . . . . . . . . . . . . . 14 3.6 Determining similar movies

Emmerich, Michael

123

Magazine van de Universiteit Leiden `ik betrek mijn  

E-print Network

de Haan, Frank de Ruiter, Martijn de Vries, medewerkers aan dit nummer Beatrijs Bonarius, MarjoleinMagazine van de Universiteit Leiden `ik betrek mijn netwerk bij de colleges' Jaap de Hoop Scheffer CaMPUs den Haag academisch onderwijs in de hofstad CLeveringaLezingen 2011 Protestrede wereldwijd

Galis, Frietson

124

Internal Report 2010-13 September 2010 Universiteit Leiden  

E-print Network

Speech Synthesis with Parallel Multi-Objective Genetic Algorithm Francesco D'Este MASTER'S THESIS Leiden The Netherlands #12;Articulatory Speech Synthesis with Parallel Multi-Objective Genetic Algorithms Francesco D a serial prototype encouraged the development of a parallel version of the algorithm. Experimental tests

Emmerich, Michael

125

Expression of the Inherently Autoreactive Idiotope 9G4 on Autoantibodies to Citrullinated Peptides and on Rheumatoid Factors in Patients with Early and Established Rheumatoid Arthritis  

PubMed Central

Background The pre-symptomatic stage of Rheumatoid arthritis (RA) is associated with pro-inflammatory cytokines and autoantibodies. High levels and epitope spread by Rheumatoid factors (RhF) and autoantibodies to citrullinated proteins signify progression towards disease expression. In established RA, the persistence of high autoantibody levels reflects production by both long-lived plasma cells and short-lived plasmablasts. Neither the relative contributions to pathogenesis by autoantibodies from either source, nor the factors responsible for deciding the fate of autoantigen specific ‘parent’ B-cells, is understood. Phenotypic markers identifying subsets of autoreactive B-cells are therefore of interest in understanding the origin and perpetuation of the autoimmune response in RA. One such phenotypic marker is the rat monoclonal antibody, 9G4, which recognises an idiotope on immunoglobuins derived from the inherently autoreactive VH-gene, VH4-34. We therefore investigated whether the 9G4 idiotope was expressed on autoantibodies in patients with RA. Methodology/Principal Findings Sera from 19 patients with established RA and those with <1year history of untreated polyarthritis either resolving into RA (n?=?42) or non-RA diagnosis (n?=?31) were included. Autoantibodies to cyclic citrullinated peptides (CCP), RhF and co-expression of the 9G4 idiotope were measured by ELISA. 9G4 recognised a population of anti-CCP antibodies in the majority of sera from patients with established disease and also in samples from patients with early disaese. 9G4+RhF levels were generally lower and not associated with positivity for, or levels of 9G4+CCP. Conclusions/Significance The persistence of 9G4+ immunoglobulins, of any isotype, in serum is rare. We describe here the novel finding of 9G4 expression on anti-CCP antibodies in patients from the earliest symptoms of RA through to established disease. Our results suggest that 9G4 expression on anti-CCP autoantibodies was not due to polyclonal expansion of VH4-34-encoded immunoglobulins. These studies may therefore provide a new focus for investigation into the evolution of the autoimmune response in RA patients. PMID:25222933

Cambridge, Geraldine; Moura, Rita A.; Santos, Tania; Khawaja, Akif A.; Polido-Pereira, Joaquim; Canhão, Helena; Leandro, Maria J.; Fonseca, João E.

2014-01-01

126

CRP genotype and haplotype associations with serum C-reactive protein level and DAS28 in untreated early rheumatoid arthritis patients.  

PubMed

IntroductionSingle nucleotide polymorphisms (SNPs) in the CRP gene are implicated in the regulation of the constitutional C-reactive protein (CRP) expression and its response to pro-inflammatory stimuli. Previous reports suggest these effects may have an impact on clinical decision-making based on CRP, for example DAS28. We aimed to investigate the possible association between 7 CRP SNPs, their haplotypes, and the serum level of CRP as well as the DAS28 score in two cohorts of untreated active early rheumatoid arthritis (RA) patients followed during their initial treatment.MethodsOverall, 315 disease-modifying anti-rheumatic drugs and steroid naïve RA patients with disease duration <6 months were included from two randomized controlled trials (the CIMESTRA and OPERA trials). Seven CRP SNPs were investigated: rs11265257, rs1130864, rs1205, rs1800947, rs2808632, rs3093077 and rs876538. The genotype and haplotype associations to CRP and DAS28 levels were evaluated using linear regression analysis adjusted for age, sex and treatment.ResultsThe minor allele of rs1205 C¿>¿T was associated with decreased CRP levels at baseline (P =0.03), with the TT genotype having a 50% reduction in CRP from 16.7 to 8.4 mg/L (P =0.005) compared to homozygosity of the major allele, but no association was observed at year one (P =0.38). The common H2 haplotype, characterized by the T allele of rs1205, was associated with a 26% reduction in CRP at baseline (P =0.043), although no effect was observed at year one (P =0.466). No other SNP or haplotype was associated with CRP at baseline or year one (P ¿0.09). We observed no associations between SNPs or haplotypes and DAS28 scores at baseline or year one (P ¿0.10).Conclusion CRP genotype and haplotype were only marginally associated with serum CRP levels and without any association to the DAS28 score. This study shows that DAS28, the core parameter for inflammatory activity in RA, can be used for clinical decision-making without adjustment for CRP gene variants.Trial registrationThe OPERA study is registered at clinicaltrials.gov (NCT00660647). The Cimestra study is not listed in a clinical trials registry due to inclusion of patients between October 1999 and October 2002. PMID:25359432

Ammitzbøll, Christian; Steffensen, Rudi; Bøgsted, Martin; Hørslev-Petersen, Kim; Hetland, Merete L; Junker, Peter; Johansen, Julia S; Pødenphant, Jan; Ostergaard, Mikkel; Ellingsen, Torkell; Stengaard-Pedersen, Kristian

2014-10-31

127

Evaluation of serum IL-6 level as a surrogate marker of synovial inflammation and as a factor of structural progression in early rheumatoid arthritis: Results from the ESPOIR cohort.  

PubMed

Objective: Interleukin-6 (IL-6) is a key cytokine in Rheumatoid Arthritis (RA) pathogenesis. We aimed to analyze the association between IL-6 serum levels and joint inflammation at baseline and the correlation of time-integrated IL-6 values with structural damage during the first 36 months of early arthritis. Methods: IL-6 was assessed by two different methods in 813 patients of the French early arthritis cohort ESPOIR over 36 months. IL-6 and C-reactive protein (CRP) changes were correlated to radiographic progression assessed by total Sharp-van der Heijde score (SHS). Synovium inflammation was assessed in a subgroup of 126 patients by ultrasonography (US). The relationship between SHS change and IL-6 or CRP levels at baseline was investigated by a univariate regression and a multivariable analysis. A longitudinal model nested by visit and patient was conducted to assess the role of IL-6 on SHS at each visit. Results: At baseline, IL-6 was more strongly correlated with the swollen joint count than CRP. In the univariate analysis, time-integrated value of IL-6 was more strongly correlated with the swollen joint count and the variation of SHS than time-integrated CRP. Baseline IL-6 was not independently associated with SHS change. Longitudinal models nested by patient showed that IL-6 levels were associated with structural damage independently from DAS28, smocking status, Rheumatoid Factor and Anti-Citrullinated Protein/Peptide Antibody serology, treatments and CRP levels. Conclusion: IL-6 level was a marker of US synovitis at baseline. Repeated measurements of IL-6 are associated with structural damage. © 2014 American College of Rheumatology. PMID:25384758

Baillet, Athan; Gossec, Laure; Paternotte, Simon; Etcheto, Adrien; Combe, Bernard; Meyer, Olivier; Mariette, Xavier; Gottenberg, Jacques-Eric; Dougados, Maxime

2014-11-10

128

Pain and microcrystalline arthritis.  

PubMed

Microcrystals are responsible for some of the most common and complex arthropathies which are often accompanied by intense, severe pain and inflammatory reactions. The main pathogens are crystals of monosodium urate (MSU), responsible for the gout, calcium pyrophosphate (CPP), which deposits also in various clinical forms of arthopathies, and basic calcium phosphate associated with osteoarthritis. In this context, the microcrystal arthritis is characterized by multiple, acute attacks followed by chronic pain, disability, impaired quality of life, and increased mortality. Given their chronic nature, they represent an ever more urgent public health problem. MSU and CPP crystals are also able to activate nociceptors. The pain in mycrocrystalline arthritis (MCA) is an expression of the inflammatory process. In the course of these diseases there is an abundant release of inflammatory molecules, including prostaglandins 2 and kinins. Interleukin-1 represents the most important cytokine released during the crystal-induced inflammatory process. Therefore, clinically, pain is the most important component of MCA, which lead to functional impairment and disability in a large proportion of the population. It is fundamental to diagnose these diseases as early as possible, and to this aim, to identify appropriate and specific targets for a timely therapeutic intervention. PMID:24938197

Ramonda, R; Frallonardo, P; Oliviero, F; Lorenzin, M G; Ortolan, A; Scanu, A; Punzi, L

2014-01-01

129

Evaluating drug-free remission with abatacept in early rheumatoid arthritis: results from the phase 3b, multicentre, randomised, active-controlled AVERT study of 24?months, with a 12-month, double-blind treatment period  

PubMed Central

Objectives To evaluate clinical remission with subcutaneous abatacept plus methotrexate (MTX) and abatacept monotherapy at 12?months in patients with early rheumatoid arthritis (RA), and maintenance of remission following the rapid withdrawal of all RA treatment. Methods In the Assessing Very Early Rheumatoid arthritis Treatment phase 3b trial, patients with early active RA were randomised to double-blind, weekly, subcutaneous abatacept 125?mg plus MTX, abatacept 125?mg monotherapy, or MTX for 12?months. Patients with low disease activity (Disease Activity Score (DAS)28 (C reactive protein (CRP)) <3.2) at month 12 entered a 12-month period of withdrawal of all RA therapy. The coprimary endpoints were the proportion of patients with DAS28 (CRP) <2.6 at month 12 and both months 12 and 18, for abatacept plus MTX versus MTX. Results Patients had <2?years of RA symptoms, DAS28 (CRP) ?3.2, anticitrullinated peptide-2 antibody positivity and 95.2% were rheumatoid factor positive. For abatacept plus MTX versus MTX, DAS28 (CRP) <2.6 was achieved in 60.9% versus 45.2% (p=0.010) at 12?months, and following treatment withdrawal, in 14.8% versus 7.8% (p=0.045) at both 12 and 18?months. DAS28 (CRP) <2.6 was achieved for abatacept monotherapy in 42.5% (month 12) and 12.4% (both months 12 and 18). Both abatacept arms had a safety profile comparable with MTX alone. Conclusions Abatacept plus MTX demonstrated robust efficacy compared with MTX alone in early RA, with a good safety profile. The achievement of sustained remission following withdrawal of all RA therapy suggests an effect of abatacept's mechanism on autoimmune processes. Trial registration number NCT01142726. PMID:25367713

Emery, Paul; Burmester, Gerd R; Bykerk, Vivian P; Combe, Bernard G; Furst, Daniel E; Barré, Emilie; Karyekar, Chetan S; Wong, Dennis A; Huizinga, Tom W J

2015-01-01

130

What Is Psoriatic Arthritis?  

MedlinePLUS

... necessary for most people with psoriatic arthritis. Improved Quality of Life Recent advances are allowing many with psoriatic arthritis to experience remarkable improvements. It is believed that ongoing research will advance current treatments and continue to improve ...

131

Headache and Arthritis  

MedlinePLUS

... cases the spine may be involved, frequently the cervical spine (the vertebrae of the neck). The areas of the neck most commonly afflicted by rheumatoid arthritis are the first and second cervical vertebra. The more common form of arthritis is ...

132

Arthritis and the Feet  

MedlinePLUS

... percent of the most serious cases, usually of rheumatoid arthritis, result in such severe disability that walking aids or wheelchairs are required. The objectives in the treatment of arthritis are controlling inflammation, preserving joint function ( ...

133

What Is Juvenile Arthritis?  

MedlinePLUS

... workers. Do Children With Juvenile Arthritis Have to Limit Activities? Pain sometimes limits what children with juvenile arthritis can do. However, ... your child’s doctor may advise your child to limit certain activities. It will depend on the joints ...

134

Arthritis of the Hand  

MedlinePLUS

... American Academy of Orthopaedic Surgeons. Arthritis of the Hand The hand and wrist have multiple small joints that work ... Arthritis can occur in many areas of the hand and wrist and can have more than one ...

135

Sex and Arthritis  

MedlinePLUS

... Pain Pregnancy and Rheumatic Disease Sex and Arthritis Sex and Arthritis PRINT Download PDF Description Sexuality is ... sensation Erectile dysfunction or impotence Begin overcoming barriers Sex is not simply about reaching rapid orgasm with ...

136

Estimates Childhood Arthritis  

MedlinePLUS

... find a rheumatologist, use the American College of Rheumatology Geographic Membership Directory . Data Source: Sacks JJ, Helmick ... visits from selected pediatric conditions Childhood Arthritis and Rheumatology Research Alliance (CARRA) Arthritis Foundation American College of ...

137

Juvenile Idiopathic Arthritis  

MedlinePLUS

... of inflammatory problems. What is Juvenile Idiopathic Arthritis (JIA)? JIA is defined as arthritis (inflammation of the ... confirm the diagnosis. What are the symptoms of JIA? Symptoms include joint pain and tenderness, redness over ...

138

Arthroscopic washout of the ankle for septic arthritis in a three-month-old boy  

PubMed Central

There is no report of athroscopic treatment for septic arthritis of the ankle in infants. We report a case of successful management of septic arthritis of the ankle in a three-month-old boy by arthroscopic washout. Arthroscopic washout may be a useful treatment for septic arthritis in young infants when performed early after onset. PMID:21961455

2011-01-01

139

Anglo-French contributions to the recognition of rheumatoid arthritis  

PubMed Central

Early descriptions of rheumatoid arthritis in the English and French literature are reviewed. Charcot pointed out that the disease was recognised as distinct from gout in eighteenth century England, and pictorial evidence for this is presented. His own work on arthritis led to a series of noteworthy interactions with Alfred Baring Garrod, which are discussed. Images PMID:7051988

Fraser, Kevin J.

1982-01-01

140

Psoriatic Arthritis: An Update  

PubMed Central

Psoriatic arthritis is a debilitating condition, which affects approximately one-quarter of psoriasis patients. Recent findings have furthered our understanding of the complex pathophysiology of PsA. There have been major advances in the identification of genes associated with joint involvement but not with cutaneous disease alone. The elucidation of key immunologic pathways has allowed the development of novel targeted therapies that are in the research pipeline. Currently, good screening tests and biomarkers to diagnose early PsA and to guide therapy are limited. In this paper, we present recent findings with regard to the immunopathogenesis and genetics of PsA, biomarkers, and screening tools and review the targeted therapies currently in clinical trials. PMID:23209897

Lloyd, Peter; Ryan, Caitriona; Menter, Alan

2012-01-01

141

[Progression of rheumatoid arthritis].  

PubMed

In order to recognize courses with high and low progression in rheumatoid arthritis deviating from former approach the values of a locomotor function test were used which do not belong to the dispersion region for the adequate classes of duration of a disease. With the help of a material of an electronic data processing study of 1,000 cases with ascertained diagnosis correlations between high progression and, among others, following criteria could be ascertained: male sex, old age, early beginning of the disease, manual trades, unfavourable functional values and very much changed laboratory values including high titres of the rheumatoid factor. In this method there was no relation to the duration of the disease, as it was existing with other methods of the determination of progression which were comparatively included into the investigation. PMID:960871

Keitel, W; Uhle, R

1976-07-01

142

Pathophysiology of rheumatoid arthritis.  

PubMed

Understanding the pathophysiologic joint changes of rheumatoid arthritis will help the nurse practitioner educate clients in therapeutic modalities such as drugs, exercise, rest, heat and cold, and splints. Uncontrolled inflammation of the affected joints is the client's worst enemy. If inflammation could be controlled early in the disease process and thus limited to synovial tissue without pannus formation and subsequent cartilage destruction, normal joint function could be more optimally maintained. But once fibrotic tissue has formed, the resulting damage to the cartilage and joint destruction cannot be reversed. The earlier treatment is initiated and the sooner the client is educated, the less advanced and crippling this disease could be physically, psychologically, emotionally and socially. PMID:7110643

Strodthoff, C

1982-06-01

143

Future trends in research in psoriatic arthritis.  

PubMed

Major advances have taken place in the study of psoriatic arthritis (PsA) in the past several decades. Future trends in research will likely be based on these advances and will span a wide spectrum of activities including further refinement of disease definition and particularly disease pattern. More precise definitions for axial and peripheral disease and in particular arthritis mutilans will be necessary for further genetic and biomarker studies. Early definition of PsA is crucial. Future research will concentrate on identifying genetic and other biomarkers for early diagnosis, disease expression, disease progression, and comorbidities. Newer therapies will be developed as well. PMID:22751608

Gladman, Dafna D

2012-07-01

144

Biologic therapies for juvenile arthritis  

PubMed Central

A group of therapies with exciting potential has emerged for children and young people with severe juvenile idiopathic arthritis (JIA) uncontrolled by conventional disease modifying drugs. Theoretical understanding from molecular biologic research has identified specific targets within pathophysiological pathways that control rheumatoid arthritis (RA) and JIA. This review identifies the pathways of autoimmunity to begin to show how biologic agents have been produced to replicate, mimic, or block culpable molecules and so promote or inhibit cellular activity or proliferation. Of these agents, cytokine antagonists have shown greatest promise, and early clinical studies of tumour necrosis factor (TNF) blockade have identified dramatic clinical benefit in many children with JIA. However, as will also be discussed, overlap of pathways within a complex immune system makes clinical response unpredictable and raises additional ethical and administrative concerns. PMID:12598373

Wilkinson, N; Jackson, G; Gardner-Medwin, J

2003-01-01

145

An historical review of rheumatoid arthritis treatment:1948 to 1952  

Microsoft Academic Search

Objectives:The early responses by practicing physicians to the discovery of the effect of cortisone (compound E) and adrenocorticotropic hormone (ACTH) on acute rheumatoid arthritis in 1948 and their reactions to the drugs' scarcity have been reviewed.

Jacob Karsh; Geza Hetenyi

1997-01-01

146

Genotyping for disease associated HLA DR ?1 alleles and the need for early joint surgery in rheumatoid arthritis: a quantitative evaluation  

PubMed Central

OBJECTIVE—To determine the value of HLA DR ?1 disease associated epitope (DAE) and erythrocyte sedimentation (ESR) in predicting the need for major joint replacement in rheumatoid arthritis (RA).?METHODS—Sixty five RA patients who had undergone hip, knee or shoulder arthroplasty within 15 years of disease onset and 65 who had not. HLA DR ?1 genotype was determined by polymerase chain reaction. ESR at first hospital visit was noted.?RESULTS—Significantly more patients with two DAE required surgery, (32% v 9%), ?2 = 13.9, p=0.001, odds ratio=5.4 (95% CI: 1.8, 16). Sensitivity was poor, 32%, specificity high, 91%. Presentation ESR was higher in surgery patients compared with non-surgery patients, 52 mm 1st h v 25 mm 1st h, p< 0.001, but was independent of DAE status. Sensitivity of an ESR of 30 mm 1st h was 75%, specificity 53%.?CONCLUSION—The presence of two DAE is a risk factor for major joint surgery in RA and is independent of ESR, whereas in those with one or no DAE, a high ESR is an important predictor.?? Keywords: HLA DR ?1; erythrocyte sedimentation rate; rheumatoid arthritis PMID:10343527

Crilly, A.; Maiden, N.; Capell, H.; Madhok, R.

1999-01-01

147

Psoriatic arthritis in Asia.  

PubMed

Geographic or ethnic differences in the occurrence of disease often provide insights into causes of disease and possible opportunities for disease prevention. A wide variation on the incidence and prevalence of PsA was reported in different countries. The prevalence in China was similar to the rest of the world, whereas the incidence and prevalence of PsA was much lower in Japan. Among patients with psoriasis, 6-42% of the Caucasians were reported to have PsA, but figures were lower from Asian countries (1-9%). Divergent distribution of HLA in different ethnic groups and other genetic determinants may account for these differences in prevalence. PsA affects men and women almost equally in Chinese, Japanese and Iranians, which is similar to their Caucasian counterparts. Polyarthritis developing in the fourth decade was the commonest pattern of arthritis among Chinese, Indians, Iranians, Kuwaiti Arabs and Malays. Arthritis mutilans and eye lesions have rarely been reported in Asian countries. Chinese patients with nail disease and DIP joints involvement have a significantly higher risk of developing deformed joints. More data are required on the safety, efficacy and cost effectiveness of TNF blockers for the treatment of PsA in Asia. Premature atherosclerosis has been recognized as an important co-morbidity in Asian patients with PsA. Increased prevalence of traditional cardiovascular risk factors associated with PsA suggested that the two conditions may share the same inflammatory pathway. Carotid intima-media thickness can identify PsA patients with subclinical atherosclerosis who may benefit from early intervention. PMID:19713440

Tam, Lai-Shan; Leung, Ying-Ying; Li, Edmund K

2009-12-01

148

Rheumatoid arthritis affecting temporomandibular joint  

PubMed Central

Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune inflammatory disorder that is characterized by joint inflammation, erosive properties and symmetric multiple joint involvement. Temporomandibular joint (TMJ) is very rare to be affected in the early phase of the disease, thus posing diagnostic challenges for the dentist. Conventional radiographs fail to show the early lesions due to its limitations. More recently cone-beam computed tomography (CBCT) has been found to diagnose the early degenerative changes of TMJ and hence aid in the diagnosis of the lesions more accurately. Our case highlights the involvement of TMJ in RA and the role of advanced imaging (CBCT) in diagnosing the bony changes in the early phase of the disease.

Sodhi, Amandeep; Naik, Shobha; Pai, Anuradha; Anuradha, Ardra

2015-01-01

149

The factor V Leiden mutation is not a common cause of recurrent miscarriage  

Microsoft Academic Search

Some investigators suggest that placental thrombosis and infarction can cause recurrent miscarriage. We have shown that the common missense mutation in the factor V gene, the Leiden mutation, which renders factor Va resistant to cleavage inactivation by activated protein C, predisposes to placental thrombosis and spontaneous miscarriage. Our objective was to determine the frequency of the Leiden mutation in a

Donna. S Dizon-Townson; Sonja Kinney; D Ware Branch; Kenneth Ward

1997-01-01

150

Rheumatoid Arthritis Educational Video Series  

MedlinePLUS

... Rheumatoid Arthritis Educational Video Series Rheumatoid Arthritis Educational Video Series This series of five videos was designed ... Activity Role of Body Weight in Osteoarthritis Educational Videos for Patients Rheumatoid Arthritis Educational Video Series Psoriatic ...

151

Treatment of rheumatoid arthritis using photodynamic therapy  

NASA Astrophysics Data System (ADS)

The only early therapy of rheumatoid arthritis in orthopedic surgery is a synovectomy, which is restricted to more or less big joints. A laser-synovectomy of small joints is ineffective yet. An alternative method may be photodynamic therapy. In our study we describe the photodynamic effect of Photosan 3 in a cell culture study.

Hendrich, Christian; Diddens, Heyke C.; Nosir, Hany R.; Siebert, Werner E.

1994-10-01

152

Treatment of rheumatoid arthritis using photodynamic therapy  

NASA Astrophysics Data System (ADS)

The only early therapy of rheumatoid arthritis in orthopedic surgery is a synovectomy, which is restricted to more or less big joints. A laser-synovectomy of small joints is ineffective yet. An alternative method may be photodynamic therapy. In our study we describe the photodynamic effect of Photosan 3 in a cell culture study.

Hendrich, Christian; Diddens, Heyke C.; Nosir, Hany R.; Siebert, Werner E.

1995-03-01

153

Quick Stats on Arthritis  

MedlinePLUS

... Publications Chronological Topic Based Healthy People Reports Podcasts Interventions Self-Management Campaigns Physical Activity. The Arthritis Pain Reliever Download Campaign Materials Download Spanish Materials Download ...

154

Classification of Psoriatic Arthritis  

MedlinePLUS

Toggle navigation Large Dropdown Menu Psoriasis About Psoriasis Treatments Related Conditions Women and Psoriasis Life with Psoriasis Access Health Care Resources and Tools Educational Webcasts Psoriatic Arthritis ...

155

Treating Psoriatic Arthritis  

MedlinePLUS

Toggle navigation Large Dropdown Menu Psoriasis About Psoriasis Treatments Related Conditions Women and Psoriasis Life with Psoriasis Access Health Care Resources and Tools Educational Webcasts Psoriatic Arthritis ...

156

Diagnosing Psoriatic Arthritis  

MedlinePLUS

Toggle navigation Large Dropdown Menu Psoriasis About Psoriasis Treatments Related Conditions Women and Psoriasis Life with Psoriasis Access Health Care Resources and Tools Educational Webcasts Psoriatic Arthritis ...

157

Hallux metatarsophalangeal arthritis.  

PubMed

Arthritis of the hallux metatarsophalangeal joint is a common disorder that affects shoewear, ambulation, and other activities of daily living. Etiologies include degenerative arthritis (hallux rigidus), crystal induced arthropathy (gout, pseudogout), rheumatoid arthritis, the seronegative spondyloathropathies, posttraumatic degeneration, and advanced hallux valgus. Accurate diagnosis and selection of the appropriate intervention depends on recognition of pertinent clinical and radiographic features. This study presents a synopsis of the senior author's (LCS) experience with 439 surgically treated patients with hallux metatarsophalangeal arthritis, focusing on origin and treatment. PMID:9584362

Weinfeld, S B; Schon, L C

1998-04-01

158

Psoriatic arthritis for the dermatologist.  

PubMed

Psoriatic arthritis (PsA) is a chronic, progressive, inflammatory spondyloarthropathy that affects approximately one-third of patients with all types of psoriasis. Dermatologists are in a unique position to recognize early symptoms of PsA, initiate appropriate therapy, and prevent development of further disability. The course of PsA can be modulated by immunosuppressive therapy; patients with moderate-to-severe disease require aggressive management with medications proven to halt disease progression. It is essential for the dermatologist to understand the safety, tolerability, efficacy, cost, and potential to halt disease progression with available medications for this relatively common and potentially disabling disease. PMID:25412788

Tintle, Suzanne J; Gottlieb, Alice B

2015-01-01

159

N-acetyl-beta-D-glucosaminidase urinary excretion as an early indicator of kidney damage in rheumatoid arthritis patients starting on parenteral gold and Depo-Medrone/placebo injections.  

PubMed

The purpose of the study was to determine the effect of initiation of gold therapy on glomerular and tubular integrity. Urine albumin was used as a marker of glomerular damage. N-acetyl-beta-D-glucosaminidase (NAG) urinary excretion served as an indicator of proximal tubular damage. This study was an adjunct to a clinical trial that investigated the safety and the efficacy of Depo-Medrone during the induction phase of gold therapy. The NAG activities and albumin levels in the urine of 36 patients with active rheumatoid arthritis treated with sodium aurothiomalate weekly up to a total of 1 g were investigated. NAG was assayed in 565 early morning urine samples of these patients at weekly intervals for 24 weeks. The mean NAG level rose from 50.2 nmol/mg of creatinine on entry to peak NAG excretion of 120.4 nmol/mg of creatinine at week 4 and then fell to 56.3 nmol/mg of creatinine at week 24. Urinary albumin was assayed in 252 early morning urine samples at monthly intervals during gold treatment. Values greater than 20 mg/l were observed in 7.5% of urine samples. Microalbuminuria was present in 9% of patients at baseline. Two patients who were withdrawn because of proteinuria and macroalbuminuria had normoalbuminuria on entry. We conclude that raised levels of NAG associated with tubular damage are more frequent than glomerular damage on entry to, and during, treatment with gold salts. PMID:10357114

Wiland, P; Szechi?ski, J

1999-01-01

160

Profile of arthritis disability.  

PubMed Central

Using the 1994-95 National Health Interview Supplement Disability Supplement, the authors study levels of disabilities and accommodations among US adults with arthritis disability, compared to people with disability due to other conditions. Arthritis-disabled people are defined in two ways. One definition covers a broad range of arthritis and rheumatic conditions, and the other concentrates solely on arthritis. The authors find that arthritis-disabled people have more total disabilities than other-disabled peop e. However, their disabilities are less severe, have shorter durations, and accumulate more gradually over time. Despite more disabilities, people with arthritis disability use fewer assistive and service accommodations than other-disabled people. They do use more mobility aids. Because arthritis is the leading chronic condition for middle-aged and older adults, th s profile of extensive but mild-to-moderate disability is experienced by many millions of adults. Accommodations for arthritis may also be extensive but aimed more toward self-care than toward assistive and medical services. PMID:11889283

Verbrugge, L. M.; Juarez, L.

2001-01-01

161

Arthritis in children.  

PubMed

Chronic arthritis in children is uncommon. Careful clinical and laboratory studies over many years have defined subgroups of disease that have their characteristic pattern of joint development and disease course. The prognosis for children who have arthritis is generally excellent but it may take years of care by a variety of specialists to achieve optimum results. PMID:3899235

Craft, A W

1985-04-01

162

Sirt2 suppresses inflammatory responses in collagen-induced arthritis  

SciTech Connect

Highlights: •Sirt2 expression decreases in collagen-induced arthritis (CIA). •Sirt2 knockout aggravates severity of arthritis in mice with CIA. •Sirt2 knockout increases levels of pro-inflammatory factors in the serum. •Sirt2 deacetylates p65 and inhibits pro-inflammatory factors expression. •Sirt2 rescue abates severity of arthritis in mice with CIA. -- Abstract: Arthritis is a common autoimmune disease that is associated with progressive disability, systemic complications and early death. However, the underling mechanisms of arthritis are still unclear. Sirtuins are a NAD{sup +}-dependent class III deacetylase family, and regulate cellular stress, inflammation, genomic stability, carcinogenesis, and energy metabolism. Among the sirtuin family members, Sirt1 and Sirt6 are critically involved in the development of arthritis. It remains unknown whether other sirtuin family members participate in arthritis. Here in this study, we demonstrate that Sirt2 inhibits collagen-induced arthritis (CIA) using in vivo and in vitro evidence. The protein and mRNA levels of Sirt2 significantly decreased in joint tissues of mice with CIA. When immunized with collagen, Sirt2-KO mice showed aggravated severity of arthritis based on clinical scores, hind paw thickness, and radiological and molecular findings. Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-?B) at lysine 310, resulting in reduced expression of NF-?B-dependent genes, including interleukin 1? (IL-1?), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13. Importantly, our rescue experiment showed that Sirt2 re-expression abated the severity of arthritis in Sirt2-KO mice. Those findings strongly indicate Sirt2 as a considerably inhibitor of the development of arthritis.

Lin, Jiangtao [Department of Orthopaedics, Qilu Hospital, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012 (China) [Department of Orthopaedics, Qilu Hospital, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012 (China); Department of Orthopaedics, Yantaishan Hospital, 91 Jiefang Road, Yantai, Shandong 264001 (China); Sun, Bing; Jiang, Chuanqiang; Hong, Huanyu [Department of Orthopaedics, Yantaishan Hospital, 91 Jiefang Road, Yantai, Shandong 264001 (China)] [Department of Orthopaedics, Yantaishan Hospital, 91 Jiefang Road, Yantai, Shandong 264001 (China); Zheng, Yanping, E-mail: yanpingzheng@yahoo.com [Department of Orthopaedics, Qilu Hospital, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012 (China)] [Department of Orthopaedics, Qilu Hospital, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012 (China)

2013-11-29

163

Salmonella enteridis Septic Arthritis: A Report of Two Cases  

PubMed Central

Introduction. Nontyphoidal salmonellosis causes significant morbidity, is transmitted via fecal-oral route, and is a worldwide cause of gastroenteritis, bacteremia, and local infections. Salmonella is a less common etiologic factor for septic arthritis compared with other gram-negative bacteria. Cases. We present two septic arthritis cases with Salmonella enteridis as a confirmed pathogen and also discuss the predisposing factors and treatment. Discussion. Septic arthritis is an orthopedic emergency. The gold standard treatment of septic arthritis is joint debridement, antibiotic therapy according to the culture results, and physiotherapy, which should start in the early postoperative period to prevent limitation of motion. Salmonella is an atypical agent for septic arthritis. It must be particularly kept in mind as an etiologic factor for the acute arthritis of a patient with sickle cell anemia and systemic lupus erythematosus. Clinicians should be cautious that the white blood cell count in synovial fluid can be under 50.000/mm3 in immune compromised individuals with septic arthritis. The inflammatory response can be deficient, or the microorganism may be atypical. Conclusion. Atypical bacteria such as Salmonella species in immune compromised patients can cause joint infections. Therefore, Salmonella species must always be kept in mind for the differential diagnosis of septic arthritis in a clinically relevant setting. PMID:24251049

Uygur, Esat; Reddy, Krishna; Özkan, Feyza Ünlü; Söylemez, Salih; Aydin, Özlem; ?enol, Serkan

2013-01-01

164

Progression and regression of atherosclerosis in APOE3Leiden transgenic mice: an immunohistochemical study  

Microsoft Academic Search

Apolipoprotein E3-Leiden (APOE3-Leiden) transgenic mice develop hyperlipidemia and are highly susceptible to diet-induced atherosclerosis. We have studied the progression and regression of atherosclerosis using immunohistochemistry. Female transgenic mice were fed a moderate fat diet to study atherosclerosis over a longer time period. Fatty streaks arose in the intima and consisted of lipid filled macrophages which differed in origin. All macrophages

Marion J. J Gijbels; Maarten van der Cammen; Luc J. W van der Laan; Jef J Emeis; Louis M Havekes; Marten H Hofker; Georg Kraal

1999-01-01

165

Heredity and Arthritis  

MedlinePLUS

... between smoking and DR4 that leads to an increased rheumatoid arthritis risk. Genetics and lupus Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that can affect skin, joints, kidneys, lungs ...

166

Arthritis: Data and Statistics  

MedlinePLUS

... About CDC.gov . Arthritis Share Compartir Data and Statistics National Statistics Based on 2010-2012 data from the National ... survey conducted by the National Center for Health Statistics. Each year, the NHIS samples U.S. households and ...

167

[Yersinia arthritis (author's transl)].  

PubMed

Clinical picture and differential diagnosis of Yersinia arthritis are shown by means of three own observations. It is an acute oligoarthritis affecting especially knee- and ankle-joints. The involved joints are very painful, swollen and warm. There may be a history of enteritis or suspicion of acute appendicitis because of lower abdominal pain, but this is not obligatory. The laboratory parameters of inflammation (ESR, C-reactive protein, white blood count, serumproteinelectrophoresis) are changed significantly. Diagnosis is made by serum agglutination reaction (Widal-reaction) against ceesurface antigens (O-antigens) of Yersinia enterocolitica. Almost only people with the HL-A antigen B27 tend to get arthritis during Yersinia infection. The differential diagnosis has to consider reactive arthritis during Salmonella or Shigella infections, acute sarcoidosis, Reiter's disease and rheumatoid arthritis. PMID:522813

Herrlinger, J D; Wuthe, H H

1979-11-01

168

Arthritis in Children  

MedlinePLUS

... surgical drainage, and intravenous (IV) use of antibiotics. Lyme Disease An infection transmitted by the deer tick can cause a form of arthritis known as Lyme disease. (It’s called this because it was first diagnosed ...

169

What Is Psoriatic Arthritis?  

MedlinePLUS

About psoriasis Treating psoriasis Psoriatic arthritis Pso what? Bullying Info for parents Childhood psoriasis Treatments Diet Support your child Get involved At school Bullying Resources Parent's forum Find a pediatric derm Further ...

170

Arthritis and Rheumatic Diseases  

MedlinePLUS

... National Institutes of Health (NIH), leads the Federal medical research effort in arthritis and rheumatic diseases. The NIAMS ... The National Institutes of Health (NIH)—The Nation's Medical Research Agency—includes 27 Institutes and Centers and is ...

171

Arthritis in Children  

MedlinePLUS

... challenging. However, with care from a team of rheumatology professionals, most children with arthritis live full and ... JIA is used most by specialists in pediatric rheumatology, JRA is commonly used in the United States. ...

172

Juvenile Idiopathic Arthritis  

MedlinePLUS

... arthritis," or JRA.) What Happens When Someone Has JIA? People with JIA may have pain and stiffness ... or no permanent joint damage. Continue Types of JIA There are seven types of JIA: Systemic JIA ...

173

Arguments for interleukin 1 as a target in chronic arthritis  

PubMed Central

Tumour necrosis factor (TNF) and interleukin 1 (IL1) are considered as master cytokines in chronic, destructive arthritis. Therapeutic approaches in rheumatic arthritis (RA) patients so far mainly focused on TNF. Although TNF is a major inflammatory mediator in RA and a potent inducer of IL1, anti-TNF treatment is not effective in all patients, nor does it fully control the arthritic process in affected joints of good responders. Analysis of cytokine patterns in early synovial biopsy specimens of RA patients reveals prominent TNF staining in 50% of the patients, whereas IL1b staining was evident in 100%. This argues that TNF independent IL1 production occurs in some of the patients. Studies in a range of experimental arthritis models in mice make it clear that TNF is involved in early joint swelling. However, TNF alone is not arthritogenic nor destructive and exerts its arthritogenic potential through IL1 induction. Intriguingly, TNF independent IL1 production is found in many models. Its relevance is further underlined by the greater efficacy of anti-IL1 treatment as compared with anti-TNF treatment and the total lack of chronic, erosive arthritis in IL1b deficient mice. IL1b is not necessarily involved in early joint swelling, but is a crucial mediator in chronic arthritis and cartilage erosion in all models studied so far. This makes ILb an attractive target in chronic, destructive arthritis.?? PMID:11053095

van den Berg, W. B

2000-01-01

174

Arthritis: a family affair.  

PubMed

A diagnosis of arthritis affects not only those who have the disease, but also their family and close friends. Arthritis is not confined to old people, but affects people of all ages from the very young upwards. It is the biggest single cause of physical disability in the UK. It can produce a complex burden of physical and psycho-social effects. The misperception that it occurs only in later life is unhelpful for younger people. PMID:19911729

Spence, Jane

2009-01-01

175

Temporomandibular Joint Bone Tissue Resorption in Patients with Early Rheumatoid Arthritis Can Be Predicted by Joint Crepitus and Plasma Glutamate Level  

PubMed Central

The aim was to investigate whether bone tissue resorption in early RA is related to crepitus of the temporomandibular joint (TMJ) and systemic levels of inflammatory mediators and markers and sex steroid hormones. Twentynine women and 18 men with recently diagnosed RA were examined for TMJ bone erosions with computerized tomography and TMJ crepitus was assessed. Blood samples were analyzed for glutamate, 5-HT, TNF, IL-1?, IL-6, VEGF, inflammatory markers, and estradiol, progesterone and testosterone. The TMJ erosion score was positively correlated to glutamate, and TMJ crepitus where crepitus, glutamate and ESR explained 40% of the variation in the bone erosion score. In the patients without crepitus, bone erosion score was positively correlated to glutamate, which was not the case in the patients with crepitus. In conclusion, the results of this study show that TMJ bone tissue resorption can be predicted by TMJ crepitus and glutamate in early RA. PMID:20671920

Hajati, Anna-Kari; Näsström, Karin; Alstergren, Per; Bratt, Johan; Kopp, Sigvard

2010-01-01

176

Progressive pseudorheumatoid chandrodysplasia simulating juvenile rheumatoid arthritis  

Microsoft Academic Search

Four patients from a Muslim family with an inherited skeletal dyspiasia are presented. It is more crippling than usual form\\u000a of spondyloepi-physial dyspiasia tarda and the onset is very early in the life i.e. at 4 years. The disorder is progressive,\\u000a crippling and has striking clinical resemblance to juvenile rheumatoid arthritis. The striking X-ray appearance is of platyspondyly\\u000a and irregularities

Shreedhar G. Archik; Ravindra D. Kamat

1990-01-01

177

Handout on Health: Rheumatoid Arthritis  

MedlinePLUS

... prevent or reduce the effects of rheumatoid arthritis. Moving to a new place with a different climate ... role in rheumatoid arthritis and thus are potential targets for new treatments. The path between identifying the ...

178

Interstitial granulomatous dermatitis with arthritis.  

PubMed

Interstitial granulomatous dermatitis with arthritis is an uncommon disorder. In its original description, the presence of linear inflammatory indurations on the lateral aspects of the trunk (the rope sign) in association with arthritis were considered the pathognomonic clinical features. Later cases presenting with plaques and papules have been reported. Herein we describe a case of interstitial granulomatous dermatitis with arthritis without the rope sign. The present case supports the idea that interstitial granulomatous dermatitis with arthritis may have variable clinical appearances. PMID:15257555

Altaykan, Asli; Erkin, Gül; Boztepe, Gonca; Gököz, Aytaç

2004-07-01

179

Genome-Wide Investigation of DNA Methylation Marks Associated with FV Leiden Mutation  

PubMed Central

In order to investigate whether DNA methylation marks could contribute to the incomplete penetrance of the FV Leiden mutation, a major genetic risk factor for venous thrombosis (VT), we measured genome-wide DNA methylation levels in peripheral blood samples of 98 VT patients carrying the mutation and 251 VT patients without the mutation using the dedicated Illumina HumanMethylation450 array. The genome-wide analysis of 388,120 CpG probes identified three sites mapping to the SLC19A2 locus whose DNA methylation levels differed significantly (p<3 10?8) between carriers and non-carriers. The three sites replicated (p<2 10?7) in an independent sample of 214 individuals from five large families ascertained on VT and FV Leiden mutation among which 53 were carriers and 161 were non-carriers of the mutation. In both studies, these three CpG sites were also associated (2.33 10?11Leiden mutation. A comprehensive linkage disequilibrium (LD) analysis of the whole locus revealed that the original associations were due to LD between the FV Leiden mutation and a block of single nucleotide polymorphisms (SNP) located in SLC19A2. After adjusting for this block of SNPs, the FV Leiden mutation was no longer associated with any CpG site (p>0.05). In conclusion, our work clearly illustrates some promises and pitfalls of DNA methylation investigations on peripheral blood DNA in large epidemiological cohorts. DNA methylation levels at SLC19A2 are influenced by SNPs in LD with FV Leiden, but these DNA methylation marks do not explain the incomplete penetrance of the FV Leiden mutation. PMID:25265411

Aïssi, Dylan; Dennis, Jessica; Ladouceur, Martin; Truong, Vinh; Zwingerman, Nora; Rocanin-Arjo, Ares; Germain, Marine; Paton, Tara A.; Morange, Pierre-Emmanuel; Gagnon, France; Trégouët, David-Alexandre

2014-01-01

180

[Chronic arthritis in a child with primary agammaglobulinemia  

PubMed

OBJECTIVES: To report a case of a child with Bruton's disease and the unusual association with chronic aseptic arthritis resembling juvenile rheumatoid arthritis. METHODS: A 16 month-old boy was seen at the Pediatric Rheumatology unit of HC-UFG and Hospital da Criança (Goiânia- GO). The authors evaluated relevant clinical and laboratorial features, including follow-up and response to therapy. The data were then compared to previous reports published in the world literature based on a Medline search of the subject. RESULTS: Since the age of 6 months, the patient had recurrent episodes of infection that responded poorly to antibiotics. Forty days before admission, he had onset of arthritis in his left knee. The diagnosis of Bruton's disease was based on the seric levels of immunoglobulins and the response to intravenous gammaglobulin infusions. Besides improvement with this therapy, clinical characteristics and other indirect laboratorial tests highly suggested the diagnosis of chronic, aseptic arthritis. CONCLUSION: We present a case of a rare association between Bruton's disease and chronic, aseptic arthritis, very similar to juvenile rheumatoid arthritis. Early recognition of this rare aseptic articular involvement is important for early and efficient therapy with intravenous gammaglobulin infusions, avoiding unnecessary hospital admissions and inappropriate use of antibiotics. PMID:14685503

Pereira, B A; Silva, R R

1999-01-01

181

Update on the surgical treatment for rheumatoid arthritis of the wrist and hand.  

PubMed

Surgical procedures for the treatment of rheumatoid arthritis are aimed at restoring function and decreasing pain. Over the past four decades multiple procedures have been described in the management of early and late disease. This article will review the most common forms of surgery used in the treatment of rheumatoid arthritis. PMID:24530143

Chim, Harvey W; Reese, Sandra K; Toomey, Stephanie N; Moran, Steven L

2014-01-01

182

Future trends for unicompartmental arthritis of the knee: injectables & stem cells.  

PubMed

Arthritis is one of the most frequent musculoskeletal problems, causing pain, disability, and a significant economic burden. In this article, we discuss current nonsurgical injectable treatment options as well as future trends for cartilage lesions and early arthritis of the knee. We cover some potential treatments for knee osteoarthritis, including stem cell and gene therapies. PMID:24274853

Demange, Marco Kawamura; Sisto, Marco; Rodeo, Scott

2014-01-01

183

What is MRI bone oedema in rheumatoid arthritis and why does it matter?  

Microsoft Academic Search

MRI bone oedema occurs in various forms of inflammatory and non-inflammatory arthritis and probably represents a cellular infiltrate within bone. It is common in early rheumatoid arthritis and is associated with erosive progression and poor functional outcome. Histopathological studies suggest that a cellular infiltrate comprising lymphocytes and osteoclasts may be detected in subchondral bone and could mediate the development of

Fiona M McQueen; Benedikt Ostendorf

2006-01-01

184

[Factor V Leiden in women with repeated IVF failures].  

PubMed

A plenty of factors have been connected with embryo implantation and further fetus development. Recurrent implantation failure (RIF) after assisted reproductive technology (ART) forces seeking the causes of decreased endometrial receptivity. A non-haemostatic function of thrombophilic mutations such as Factor V Leiden (FVL) was considered a factor related with endometrial receptivity. One hundred eighty eight women with two or more RIF after in vitro fertilization procedures investigated for carrier status for FVL was compared with carrier status of 97 women without reproductive failure who give a birth of at least one health child. There was no significant difference in carrier status for FVL in patients and controls (5.9% and 7.2% respectively, OR 0.80, 95% CI (0.26-2.73, p>0.05). Negligible higher prevalence of FVL was fond in health subjects compared with women with RIF A slightly positive relationship was found between FVL and embryo implantation. A preliminary determination of thrombophilic status in RIF women could specify needing or rejection of anticoagulant therapy during implantation period. PMID:24501874

Ivanov, P; Konova, E; Gecheva, S; Tavyatkovska, T; Izmailov, A; Komsa-Penkova, R; Ivanov, I; Golemanov, G; Kovacheva, K; Simeonova, M

2013-01-01

185

Arthritis in Roman Britain.  

PubMed Central

The pattern of arthritis in Roman Britain was investigated by examining the skeletons of 416 adults from the Roman cemetery at Poundbury Camp near Dorchester, Dorset. The mean height of the people was not much less than that of the current British population, and the prevalence of right handedness was similar to our own. There was a high prevalence of osteoarthritis for such a relatively young community, with particularly severe changes in the vertebral column. The pattern of joints affected by osteoarthritis was different from that seen now, but the prevalence of vertebral ankylosing hyperostosis was much the same. Rheumatoid arthritis was seen as often as the expected rat would indicate, given that the population died young, but it was rare. Other forms of arthritis, including gout and ankylosing spondylitis, were not seen. Images FIG 1 FIG 2 FIG 3 FIG 4 PMID:6418269

Thould, A K; Thould, B T

1983-01-01

186

Rheumatoid arthritis impact survey.  

PubMed

A survey was undertaken to determine the effects of rheumatoid arthritis on the daily lives of patients. A randomly selected group of 135 Indians and blacks with rheumatoid arthritis were interviewed. Only 24% were employed and 35% were dependent on financial support from the state. Twenty-two per cent did not know the name of their illness and 89% expressed a desire to learn more about it. The most important problems encountered were pain (96%), stiffness (80%) and financial (58%). Activities such as toilet after-care, combing hair, bathing and dressing presented problems for a significant proportion of patients. The majority (73%) reported improvement on therapy. The survey showed that in rheumatoid arthritis, there is a great need for education and counselling of patients, there is a high unemployment rate and there is also a need for total patient care by a team of health professionals. PMID:3187821

Mody, G M; Shaw, J; Ramchurren, A

1988-10-15

187

Organizing Pneumonia Preceding Rheumatoid Arthritis  

PubMed Central

Rheumatoid arthritis patients are susceptible to interstitial lung disease, and joint manifestations of rheumatoid arthritis usually precede lung involvements by several years. Organizing pneumonia, as the first manifestation of rheumatoid arthritis, is extremely rare, and its clinical features remain currently unknown. We present a case and a literature review of patients who were pathologically diagnosed with organizing pneumonia first and met the diagnostic criteria of rheumatoid arthritis later. In this review, we observed the following: (1) patients with organizing pneumonia preceding rheumatoid arthritis have a high prevalence of rheumatoid factor or anticyclic citrullinated peptide antibodies; (2) almost all patients developed rheumatoid arthritis within one year after the diagnosis of organizing pneumonia. We suggest that patients with organizing pneumonia and positive for either rheumatoid factor or anticyclic citrullinated peptide antibody should be cautiously followed up regarding the development of rheumatoid arthritis, particularly during the first year after the diagnosis of organizing pneumonia. PMID:24600522

Kinoshita, Yoshiaki; Sakamoto, Atsuhiko; Hidaka, Kouko

2014-01-01

188

Predominant activation of MAP kinases and pro?destructive/pro?inflammatory features by TNF ? in early?passage synovial fibroblasts via TNF receptor?1: failure of p38 inhibition to suppress matrix metalloproteinase?1 in rheumatoid arthritis  

PubMed Central

Objective To examine the relative importance of tumour necrosis factor?receptor 1 (TNF?R1) and TNF?R2 and their signalling pathways for pro?inflammatory and pro?destructive features of early?passage synovial fibroblasts (SFB) from rheumatoid arthritis (RA) and osteoarthritis (OA). Methods Cells were stimulated with tumour necrosis factor (TNF)? or agonistic anti?TNF?R1/TNF?R2 monoclonal antibodies. Phosphorylation of p38, ERK and JNK kinases was assessed by western blot; proliferation by bromodesoxyuridine incorporation; interleukin (IL)6, IL8, prostaglandin E2 (PGE2) and matrix metalloproteinase (MMP)?1 secretion by ELISA; and MMP?3 secretion by western blot. Functional assays were performed with or without inhibition of p38 (SB203580), ERK (U0126) or JNK (SP600125). Results In RA? and OA?SFB, TNF??induced phosphorylation of p38, ERK or JNK was exclusively mediated by TNF?R1. Reduction of proliferation and induction of IL6, IL8 and MMP?1 were solely mediated by TNF?R1, whereas PGE2 and MMP?3 secretion was mediated by both TNF?Rs. In general, inhibition of ERK or JNK did not significantly alter the TNF? influence on these effector molecules. In contrast, inhibition of p38 reversed TNF? effects on proliferation and IL6/PGE2 secretion (but not on IL8 and MMP?3 secretion). The above effects were comparable in RA? and OA?SFB, except that TNF??induced MMP?1 secretion was reversed by p38 inhibition only in OA?SFB. Conclusion In early?passage RA/OA?SFB, activation of MAPK cascades and pro?inflammatory/pro?destructive features by TNF? is predominantly mediated by TNF?R1 and, for proliferation and IL6/PGE2 secretion, exclusively regulated by p38. Strikingly, RA?SFB are insensitive to p38 inhibition of MMP?1 secretion. This indicates a resistance of RA?SFB to the inhibition of pro?destructive functions and suggests underlying structural/functional alterations of the p38 pathway, which may contribute to the pathogenesis or therapeutic sensitivity of RA, or both. PMID:17223661

Kunisch, Elke; Gandesiri, Muktheshwar; Fuhrmann, Reneé; Roth, Andreas; Winter, Rando; Kinne, Raimund W

2007-01-01

189

Routine analysis of synovial fluid cells is of value in the differential diagnosis of arthritis in children.  

PubMed

Results of synovianalysis are reported in 129 children, 91 with juvenile rheumatoid arthritis (JRA), 13 with septic arthritis, 12 with enteroarthritis, 12 with acute transient arthritis and 1 with bacillus Calmette-Guerin arthritis. Mononuclear cells were dominant in the patients with oligoarticular JRA (mean 64%, median 74%), and among these, significantly lower proportions of polymorphonuclear (PMN) cells were found in patients with early onset disease with antinuclear antibodies or chronic uveitis than in those with late onset with HLA-B27. PMN cells were dominant in polyarticular and systemic onset JRA, septic arthritis and enteroarthritis. The sensitivity and specificity of a white cell count above 40,000/mm3 exceeded 90% in differentiating septic arthritis from the other kinds of arthritis. Measurement of total protein, glucose and lactate in synovial fluid was of limited diagnostic value. PMID:3560094

Kunnamo, I; Pelkonen, P

1986-12-01

190

Cachexia in rheumatoid arthritis  

Microsoft Academic Search

Rheumatoid arthritis is a debilitating, chronic, systemic, autoimmune disease of unknown etiology that causes destruction of joint cartilage and bone. It generally occurs between the fourth and sixth decades of life, and affects two to three times more women than men. It is characterized by joint stiffness, pain, and swelling, and is accompanied by a loss of body cell mass.

Joseph Walsmith; Ronenn Roubenoff

2002-01-01

191

What Is Rheumatoid Arthritis?  

MedlinePLUS

... publication. To order Rheumatoid Arthritis Handout on Health full-text version, please contact NIAMS using the contact information ... mailed to you? Visit our online order form. Full NIAMS Site NIH… Turning Discovery Into Health ® ... Comments Moderation Policy Site Map | Viewers and Players

192

What Is Reactive Arthritis?  

MedlinePLUS

... NIAMS publication. To order Reactive Arthritis Q&A full-text version, please contact NIAMS using the contact information ... nih.gov Website: http://www.niams.nih.gov Full NIAMS Site NIH… Turning Discovery Into Health ® ... Comments Moderation Policy Site Map | Viewers and Players

193

Enigmatic question of early reactive arthritis disclosed after researches of mycoplasmas, Chlamydia trachomatis and enteropathogens following the holistic vision of human being.  

PubMed

An HLA-B27 genetic profile patient is fully investigated by molecular analyses after an anamnestic assessment of multi-site ecosystems, following the holistic vision of human being.VDRL and Widal-Wright (WWR) resulted positive, showing at Wright?s reaction a title of 1:40. Of all the enzymatic activities measured, only the ALP enzymatic pool activities showed a low increasing value of 297 U/L. Of all later acute phase proteins, Only C3 c protein value (127 mg/dL) and fibrinogen (376 mg/dL) were altered. Cultural and molecular oropharyngeal ecosystem investigation resulted significantly positive to Mycoplasmas(Mhand Uu) and Chlamydia trachomatis(Ct) together with a spread of saprophytic flora. From an accurate anamnesis, several and severe uro-genital clinical symptomatology emerged from birth until the beginning of rheumatologic symptomatologies that were confirmed by oldest Mh, Uu and Ctsilent chronic infections between these ecosystems. The molecular HPV research was negative, while the Thin prep pap-test was indicative of vaginosis and cellular reactive changes associated with inflammation. Parasitological research resulted positive for presence of 5-7 newly-formed G. lambliacysts for microscopic field, while digestibility test was positive for presence of several free fatty acid crystals. The remarkable presence of indigested meat fibre and several mucous dense filaments were observed. The pH value was 6.5, while blood faecal test was positive. The values observed were: ferritin 12 microg/L (10-120), total iron-binding capacity (TIBC) 310 &mgr;g/dL (300+-20), unsaturated iron-binding capacity (UIBC) 286 microg/dL (200-220) and iron seric level 24 microg/dL (60-130). Faecal research highlighted a very scarce presence of E. coli, resulting in 102 UFC/g of stool. Of all enteroinvasive pathogens, researched by molecular analyses, only Yersinia spp. was positive. After several specific cycles of antibiotic and antinflammatory therapies, the patient improved its general health condition considerably and showed almost complete regression of aching inguinal lymph node inflammation. In a picture of a worsening inflammatory process, produced by pathogens like Mycoplasmas, chronic silent or low grade inflammation atypical agents, in young HLA-B27 positive patient, VDRL test resulted positive. This value represents the first non-specific unique spy to reveal the precocious immunological signal in order to register the beginning of early innate immune system decay, keeping in mind that mycoplasmal and chlamydial infections are the triggering of cancer in patients genetically susceptible. PMID:24382185

Del Boccio, M; Pennelli, A; Toniato, E; Martinotti, S; Tenaglia, R; Croce, A; Pugliese, M; Del Boccio, G; Gallenga, P E; Neri, G

2013-01-01

194

SERS-based immunoassay of anti-cyclic citrullinated peptide for early diagnosis of  

E-print Network

to be a new clinical tool for the early diagnosis of rheumatoid arthritis (RA). Rheumatoid arthritis (RASERS-based immunoassay of anti-cyclic citrullinated peptide for early diagnosis of rheumatoid arthritis Hyangah Chon,a Sangyeop Lee,a Rui Wang,a So-Young Bang,b Hye-Soon Lee,b Sang-Cheol Bae,b Hyoban

Kim, Bongsoo

195

Mistaken Identity and Mirror Images: Albert and Carl Einstein, Leiden and Berlin, Relativity and Revolution  

E-print Network

Albert Einstein accepted a 'special' visiting professorship at the University of Leiden in the Netherlands in February 1920. Although his appointment should have been a mere formality, it took until October of that year before Einstein could occupy his special chair. Why the delay? The explanation involves a case of mistaken identity with Carl Einstein, Dadaist art, and a particular Dutch fear of revolutions. But what revolution was one afraid of? The story of Einstein's Leiden chair throws new light on the reception of relativity and its creator in the Netherlands and in Germany.

Jeroen van Dongen

2012-11-14

196

Mistaken Identity and Mirror Images: Albert and Carl Einstein, Leiden and Berlin, Relativity and Revolution  

E-print Network

Albert Einstein accepted a 'special' visiting professorship at the University of Leiden in the Netherlands in February 1920. Although his appointment should have been a mere formality, it took until October of that year before Einstein could occupy his special chair. Why the delay? The explanation involves a case of mistaken identity with Carl Einstein, Dadaist art, and a particular Dutch fear of revolutions. But what revolution was one afraid of? The story of Einstein's Leiden chair throws new light on the reception of relativity and its creator in the Netherlands and in Germany.

van Dongen, Jeroen

2012-01-01

197

Mistaken Identity and Mirror Images: Albert and Carl Einstein, Leiden and Berlin, Relativity and Revolution  

NASA Astrophysics Data System (ADS)

Albert Einstein accepted a "special" visiting professorship at the University of Leiden in the Netherlands in February 1920. Although his appointment should have been a mere formality, it took until October of that year before Einstein could occupy his special chair. Why the delay? The explanation involves a case of mistaken identity with Carl Einstein, Dadaist art, and a particular Dutch fear of revolutions. But what revolutions was one afraid of? The story of Einstein's Leiden chair throws new light on the reception of relativity and its creator in the Netherlands and in Germany.

van Dongen, Jeroen

2012-06-01

198

Mistaken Identity and Mirror Images: Albert and Carl Einstein, Leiden and Berlin, Relativity and Revolution  

NASA Astrophysics Data System (ADS)

Albert Einstein accepted a 'special' visiting professorship at the University of Leiden in the Netherlands in February 1920. Although his appointment should have been a mere formality, it took until October of that year before Einstein could occupy his special chair. Why the delay? The explanation involves a case of mistaken identity with Carl Einstein, Dadaist art, and a particular Dutch fear of revolutions. But what revolution was one afraid of? The story of Einstein's Leiden chair throws new light on the reception of relativity and its creator in the Netherlands and in Germany.

Dongen, Jeroen

2012-06-01

199

Can Rheumatoid Arthritis Be Prevented?  

PubMed Central

The discovery of elevations of rheumatoid arthritis (RA)-related biomarkers prior to the onset of clinically apparent RA raises hopes that individuals who are at risk for future RA can be identified in a preclinical phase of disease that is defined as abnormalities of RA-related immune activity prior to the clinically apparent onset of joint disease. Additionally, there is a growing understanding of the immunologic processes that are occurring in preclinical RA, as well as a growing understanding of risk factors that may be mechanistically related to RA development. Furthermore, there are data supporting that treatment of early RA can lead to drug free remission. Taken as a whole, these findings suggest that it may be possible to use biomarkers and other factors to accurately identify the likelihood and timing of onset of future RA, and intervene with immunomodulatory therapies and/or risk factor modification to prevent the future onset of RA in at-risk individuals. Importantly, several clinical prevention trials for RA have already been tried, and one is underway. However, while our understanding of the growing understanding of the mechanisms and natural history of RA development may be leading us to the implementation of prevention strategies for RA, there are still several challenges to be met. These include developing sufficiently accurate methods of predicting those at high risk for future RA so that clinical trials can be developed based on accurate rates of development of arthritis and subjects can be adequately informed of their risk for disease, identifying the appropriate interventions and biologic targets for optimal prevention, and addressing the psychosocial and economic aspects that are crucial to developing broadly applicable prevention measures for RA. These issues notwithstanding, prevention of RA may be within reach in the near future. PMID:24315049

Deane, Kevin

2013-01-01

200

Cachexia in rheumatoid arthritis.  

PubMed

Rheumatoid arthritis is a debilitating, chronic, systemic, autoimmune disease of unknown etiology that causes destruction of joint cartilage and bone. It generally occurs between the fourth and sixth decades of life, and affects two to three times more women than men. It is characterized by joint stiffness, pain, and swelling, and is accompanied by a loss of body cell mass. This loss of cell mass, known as rheumatoid cachexia, predominates in skeletal muscle, but also occurs in the viscera and immune system. Thus, rheumatoid cachexia leads to muscle weakness and a loss of functional capacity, and is believed to accelerate morbidity and mortality in rheumatoid arthritis. Currently there is no established mechanism for rheumatoid cachexia, but it is accompanied by elevated resting energy expenditure, accelerated whole-body protein catabolism, and excess production of the inflammatory cytokines, tumor necrosis factor-alpha and interleukin-1beta. Tumor necrosis factor-alpha is probably the central mediator of muscle wasting in rheumatoid arthritis, and is known to act synergistically with interleukin-1beta to promote cachexia. In general, tumor necrosis factor-alpha and interleukin-1beta are thought to alter the balance between protein degradation and protein synthesis in rheumatoid arthritis to cause muscle wasting. The precise mechanism by which they do this is not known. Reduced peripheral insulin action and low habitual physical activity are important consequences of rheumatoid arthritis, and have also been implicated as mediators of rheumatoid cachexia. Insulin inhibits muscle protein degradation. Consequently, reduced peripheral insulin action in rheumatoid arthritis is thought to be permissive to cytokine-driven muscle loss. The cause of reduced peripheral insulin action in rheumatoid arthritis is not known, but tumor necrosis factor-alpha has been shown to interfere with insulin receptor signaling and is probably an important contributor. Low habitual physical activity has consistently been observed in rheumatoid arthritis and is an important consequence of, and contributor to, muscle wasting. In addition, low physical activity predisposes to fat gain and is believed to precipitate a negative reinforcing cycle of muscle loss, reduced physical function, and fat gain in rheumatoid arthritis, which leads to 'cachectic obesity'. To date, there is no standard treatment for rheumatoid cachexia. However, physical exercise is currently believed to be the most important and clinically relevant countermeasure against rheumatoid cachexia. In general, a combination of skeletal muscle strength training and aerobic exercise is recommended, but must be prescribed with the patient's disease status, overall health, and safety in mind. Future studies should investigate the safety, efficacy, and required dose of anti-cytokine therapy for the treatment of rheumatoid cachexia. In this review, we outline the current definition of rheumatoid cachexia, and discuss the etiology, pathogenesis, and treatment of rheumatoid cachexia. PMID:12163213

Walsmith, Joseph; Roubenoff, Ronenn

2002-09-01

201

[The comparative effectiveness of high-intensity dynamic training with the use of exercise machines and therapeutic gymnastics for the joints in the patients presenting with early rheumatoid arthritis].  

PubMed

The objective of the present work was to compare the effectiveness of two therapeutic exercise programs for the patients presenting with early rheumatoid arthritis (RA). The study included 51 patients. Fifteen of them (group 1) were given conventional medicamental therapy in combination with high-intensity dynamic physical exercises with the use of the Enraf-Nonius training devices (45-60 min). Eighteen patients of group 2 were offered 10 sessions of remedial gymnastics for the joints (45 min each) under the guidance of an instructor that were continued under the domestic conditions (45 min each session thrice weekly for 3 months). Eighteen patients of group 3 were given medicamental therapy alone (control). The parameters estimated in the study included the mean strength of knee joint extension and ankle joint flexion measured with the use of En-TreeM devices, articular pain (100 mm BAHI), DAS28, HAQ, and RAPID3 indices. It was shown that both programs of therapeutic exercises reduced the severity of the disease, improved the functional and motor activity of the patients and their quality of life. The majority of these characteristics were significantly different from those documented in the control group (p<0.05). The clinical effectiveness of high-intensity training with the use of exercise machines was higher than without them (articular pain was reduced by 57.9% (p<0.01), DAS28 by 24.7% (p<0.05), HAQ by 60.7% (p<0.01). RAPID3 by 47.5% (p<0.01), mean strength of extension of the weak and strong knee joints increased by 87.9% (p<0.01) and 70.5% (p<0.01) respectively, the strength of flexion of the severely and less severely affected ankle joints increased by 84.6 (p<0.01) and 68.8% (p<0.01) respectively. Compliance with regular performance of therapeutic joint exercises during 3 months was higher (83.3%) than with high-intensity dynamic training with the use of exercise machines (60%). It is concluded that the latter modality should be recommended to the younger patients with RA (below 40 years), a short history of the disease, and its low activity. PMID:23718079

Orlova, E V; Karateev, D E; Kochetkov, A V; Mozhar, T E

2013-01-01

202

Evaluation of a modified ACR20 scoring system in patients with rheumatoid arthritis receiving treatment with etanercept  

Microsoft Academic Search

Objective: To evaluate a modified American College of Rheumatology 20 (mACR20) scoring system for patients with rheumatoid arthritis.Methods: The data were evaluated from one study on patients with methotrexate (MTX)-naive early rheumatoid arthritis (ERA) and another study on patients with DMARD-refractory late rheumatoid arthritis (LRA). For mACR20 scoring, acute-phase reactant measurements were excluded, and 20% improvement from baseline was determined

J A Goldman; H A Xia; B White; H Paulus

2006-01-01

203

Amelioration of experimental arthritis by stroke-induced immunosuppression is independent of Treg cell function  

PubMed Central

Objectives Clinical evidence suggests that neurological lesions can protect from arthritis. Acute cerebral ischaemia induces severe immunosuppression, resulting in enhanced susceptibility to infections. We aimed to determine if stroke-induced immunosuppression can ameliorate arthritis and to delineate the immunological mechanisms involved. Methods Unilateral cerebral ischaemia was induced in mice by occlusion of one middle cerebral artery (MCAO) at different time points after induction of G6PI-induced arthritis in mice. Clinical and histological signs of arthritis were assessed. Regulatory T cells were specifically depleted by injection of diphtheria toxin into transgenic DEREG mice. Immunological correlates of MCAO were determined by flow cytometry and serological methods. Results MCAO reduced the clinical and histological signs of arthritis significantly. To be effective, stroke had to be induced during the induction phase or the early clinical stage of arthritis. MCAO induced a global loss of leucocytes. Despite the reduced absolute number of lymphocytes, the functional differentiation of T helper cells into Th1/17 cells and the production of autoantibodies were unimpaired. Depletion experiments showed that regulatory T cells were dispensable for the protective effect of MCAO. Conclusions MCAO ameliorates arthritis. The correlate of protection from arthritis is not the reduction of a particular pathogenic leucocyte subset or the preferential expansion or emergence of a protective cell population but the global reduction of leucocytes during arthritis. PMID:24326006

Irmler, Ingo M; Gajda, Mieczyslaw; Kamradt, Thomas

2014-01-01

204

Randomized controlled trial design in rheumatoid arthritis: the past decade  

Microsoft Academic Search

Much progress has occurred over the past decade in rheumatoid arthritis trial design. Recognized challenges have led to the establishment of a clear regulatory pathway to demonstrate efficacy of a new therapeutic. The use of pure placebo beyond 12 to 16 weeks has been demonstrated to be unethical and thus background therapy and\\/or early rescue has become regular practice. Goals

Vibeke Strand; Jeremy Sokolove

2009-01-01

205

Patients with rheumatoid arthritis have an altered circulatory aggrecan profile  

Microsoft Academic Search

BACKGROUND: Rheumatoid arthritis (RA) is a chronic auto-immune disease with extensive articular cartilage destruction. Aggrecan depletion, mediated by aggrecanases is one of the first signs of early cartilage erosion. We investigated, whether measurement of aggrecan and fragments thereof in serum, could be used as biomarkers for joint-disease in RA patients and furthermore characterized the fragments found in the circulation. METHODS:

Jean C Rousseau; Eren U Sumer; Gert Hein; Bodil C Sondergaard; Suzi H Madsen; Christian Pedersen; Thomas Neumann; Andreas Mueller; Per Qvist; Pierre Delmas; Morten A Karsdal

2008-01-01

206

Physical Activity and Psoriatic Arthritis  

MedlinePLUS

Toggle navigation Large Dropdown Menu Psoriasis About Psoriasis Treatments Related Conditions Women and Psoriasis Life with Psoriasis Access Health Care Resources and Tools Educational Webcasts Psoriatic Arthritis ...

207

Management of Rheumatoid Arthritis  

PubMed Central

Rheumatoid arthritis is a common disease, for which every physician should have a sound approach. This paper details the global management of the disease. Guidelines are given for educating the patient and assessing the level of disease activity. Common questions about the indications and uses of non-steroidal anti-inflammatory drugs, local corticosteroid injections, slow-acting agents, immunosuppressive drugs and steroids are discussed. PMID:21278947

Carette, Simon

1984-01-01

208

Arthritis and angioimmunoblastic lymphadenopathy.  

PubMed Central

We report 2 contrasting cases of a seronegative polyarthritis associated with angioimmunoblastic lymphadenopathy (AILD). Both cases were nonerosive, with symmetrical involvement of the elbows, wrists, knees, and ankles. In one the arthritis appeared concurrently with the main systemic manifestations of AILD. The second presented with polyarthritis 18 months before the onset of AILD. This patient received azathioprine for 11 months before developing AILD, which raises the possibility of this drug being the causative agent. Images PMID:6625700

Davies, P G; Fordham, J N

1983-01-01

209

Leiden Law School Department of Economics Research Memorandum 2009.02  

E-print Network

coordinates and encourages Member State actions to combat poverty, and to reform their social protectionLeiden Law School Department of Economics Research Memorandum 2009.02 Social Expenditure.economie.leidenuniv.nl Editors Prof. dr. C.L.J. Caminada Dr. B.C.J. van Velthoven #12;SOCIAL EXPENDITURE AND POVERTY REDUCTION

Galis, Frietson

210

Lightning Engine -Ray tracing with KD-trees Leiden Institute of Advanced Computer Science (LIACS)  

E-print Network

Lightning Engine - Ray tracing with KD-trees Leiden Institute of Advanced Computer Science (LIACS an overview of the architectural design of our Lightning project. The goal of this project was to design 1 Introduction 4 2 The Lightning Engine 5 2.1 Physics Engine

Emmerich, Michael

211

Ten types of microscopically identifiable airborne fungal spores at Leiden, The Netherlands  

Microsoft Academic Search

A universal method for the complete assessment of atmospheric fungal spores does not exist, which is continuous, volumetric and non-selective, and offers at the same time reliable identification of the collected spores. To perform a survey of airborne fungal spores, a choice has to be made between a viable and non-viable method. For the study carried out in Leiden, the

A. H. Nikkels; P. Terstegge; F. Th. M. Spieksma

1996-01-01

212

Factor V Leiden mutation is associated with ocular involvement in Behçet disease  

Microsoft Academic Search

PURPOSE:Behçet disease is a systemic disease of young adults characterized by venous occlusion in both the deep venous and retinal circulations. In severe ocular disease, blindness may occur despite immunosuppressive treatment. The most common inherited risk factor for the development of idiopathic venous thrombosis is the presence of the Factor V (FV Leiden) mutation, which confers resistance to activated protein

D. H Verity; R. W Vaughan; W Madanat; E Kondeatis; H Zureikat; F Fayyad; C. A Kanawati; I Ayesh; M. R Stanford; G. R Wallace

1999-01-01

213

The Warped Side of the Universe Colloquium Ehrenfestii, University of Leiden, 16 Sept 2009  

E-print Network

Rotational Motion of Space Warping of Time #12;6 Rate of Time flow Kerr Metric Map of spacetime geometry? Wild vibrations of warped spacetime #12;14 Numerical Relativity: How is it Done? Evolve the geometryThe Warped Side of the Universe Colloquium Ehrenfestii, University of Leiden, 16 Sept 2009 Kip

van den Brink, Jeroen

214

Resistance to activated protein C and the Leiden mutation: High prevalence in patients with abruptio placentae  

Microsoft Academic Search

Objective: The Leiden mutation, a point mutation in the gene encoding coagulation factor V, is associated with a high frequency of thromboembolic phenomena. It has recently been connected with adverse outcomes of pregnancy. We carried out this study to define its connection with abruptio placentae. Study Design: Twenty-seven women who had abruptio placentae and 29 control subjects matched for age,

Zofnat Wiener-Megnagi; Izhar Ben-Shlomo; Yael Goldberg; Eliezer Shalev

1998-01-01

215

The Reconstructions of Beirut The City in the Islamic World, Brill, Leiden  

E-print Network

The Reconstructions of Beirut The City in the Islamic World, Brill, Leiden Joe Nasr, independent-torn city is an extreme case, considered from the point of view of urban violence as well as from that of urban planning. Urban violence and planning must then be analyzed as conscious tools for reshaping urban

Paris-Sud XI, Université de

216

Speech Simone Buitendijk, Vice-Rector Magnificus Universiteit Leiden Symposium Excellence through diversity  

E-print Network

diversity 11 November 2014 Leiden University is doing well. We are consistently scoring high era. Their plan is being presented today. What do the research data teach us? There is overwhelming leaders than women. Even women on average prefer male leaders to female leaders. This is so firmly

Galis, Frietson

217

Activities in History of Mathematics in Utrecht and Leiden in the year 2005  

E-print Network

of Mathematics of Utrecht University (0,8) and the International Institute for Asian Studies at Leiden (0 journals in the history of science: · Ganita-Bharati (Delhi, ISSN 0970-0307), · Istoriko Mathematica (Amsterdam-San Diego, 0315-0860), · Ta'rikh-e Elm (Tehran, ISSN 1735-0573), · Journal

Hogendijk, Jan P.

218

Activities in History of Mathematics in Utrecht and Leiden in the year 2006  

E-print Network

of Mathematics of Utrecht University (0,8) and the International Institute for Asian Studies at Leiden (0 is a member of the editorial board of the following journals in the history of science: ­ Ganita'rikh-e Elm (Tehran, ISSN 1735-0573), ­ Journal for the History of Arabic Science (Aleppo, ISSN 0379

Hogendijk, Jan P.

219

Animal Biology, Vol. 57, No. 1, pp. 115-116 (2007) Koninklijke Brill NV, Leiden, 2007.  

E-print Network

available online - www.brill.nl/ab Marine Mammals: Evolutionary Biology (2nd edition) by Annalisa Berta edition of Marine Mammals: Evolutionary Biology by Annalisa Berta, James Sumich and Kit KovacsAnimal Biology, Vol. 57, No. 1, pp. 115-116 (2007) Koninklijke Brill NV, Leiden, 2007. Also

Fish, Frank

220

Klaas-Dirk van Opstal & Timo de Vries, Universiteit Leiden 8 juni 2007  

E-print Network

Digibeter Klaas-Dirk van Opstal & Timo de Vries, Universiteit Leiden 8 juni 2007 #12;1 Colofon Gemaakt door Timo de Vries 0308161 tdevries@liacs.nl Klaas-Dirk van Opstal 0326658 kvopstal Vries niet gebruikt worden voor andere doeleinden. De applicatie "Digibeter" blijft eigendom van

Emmerich, Michael

221

magazine van de universiteit leiden Nout WelliNk: fiNaNcile spil  

E-print Network

vries, frank de ruiter medewerkers aan dit nUmmer marjolein van enk, karina meerman, Jan maarten slagtermagazine van de universiteit leiden Nout WelliNk: fiNaNciële spil winter 08/09 en verder: `We leerstoel: econophysics leidse alumni in bankzaken #12;2 leidraad leidraad 3 magazine van de universiteit

Galis, Frietson

222

Bijzondere leerstoelen Universiteit Leiden faculteit naam bijzondere leerstoel stichter van de leerstoel bijzonder hoogleraar instituut  

E-print Network

Bouwhistorie Stichting Bouwhistorie Vries, D.J. de ICD FGW Diplomatieke geschiedenis Van den Berch vanBijzondere leerstoelen Universiteit Leiden faculteit naam bijzondere leerstoel stichter van de bijzonder Zuid- Afrika Van den Berch van Heemstede Stichting Ross, R. GS FGW Geschiedenis van de Friese

Galis, Frietson

223

Collagen-induced arthritis in common marmosets: a new nonhuman primate model for chronic arthritis  

PubMed Central

Introduction There is an ever-increasing need for animal models to evaluate efficacy and safety of new therapeutics in the field of rheumatoid arthritis (RA). Particularly for the early preclinical evaluation of human-specific biologicals targeting the progressive phase of the disease, there is a need for relevant animal models. In response to this requirement we set out to develop a model of collagen-induced arthritis (CIA) in a small-sized nonhuman primate species (300 to 400 g at adult age); that is, the common marmoset (Callithrix jacchus). Methods Twenty-two animals divided into three experiments were immunized with collagen type II (CII) of either bovine or chicken origin with different immunization strategies. The animals were analyzed for clinical manifestation of arthritis, hematology and clinical chemistry, immunological responses against CII and histopathological features of the arthritis. Results Clinically manifest arthritis was observed in almost 100% (21 out of 22) of the animals. Fifty percent of the animals developed semi-acute CIA while the other 50% displayed a more chronic disease. Both cellular (CD3/CD4 and CD3/CD8) and humoral responses (IgM and IgG) against CII were involved in the development of the disease. Besides mild histopathological changes in bone and cartilage, severe inflammation in extraarticular tissues like periosteum and subcutaneous tissues was observed. Conclusions This new model in marmosets more closely resembles chronic RA with respect to the chronic disease course and pathomorphological presentation than the more acute monophasic and destructive CIA model in macaques. This model can therefore fill a niche in preclinical testing of new human specific therapeutics. PMID:20977720

2010-01-01

224

Physiotherapy in pauciarticular juvenile idiopathic arthritis. Case study.  

PubMed

Juvenile idiopathic arthritis (JIA) is the most common arthropathy of childhood and adolescence. This term encompasses a group of chronic systemic inflammatory diseases of the connective tissue which cause arthritis in patients under 16 years of age lasting at least 6 weeks. The authors presented the characteristic features of physiotherapy based on functional examination results on the basis of two cases of girls with pauciarticular JIA treated according to an established pharmacological regimen. Physiotherapy should be introduced at an early stage of the disease. Kinesiotherapy preceded by history-taking and a functional examination of the patient, has to focus on both primary and secondary joint lesions. PMID:25041889

Zuk, Beata; Kaczor, Zofia; Zuk-Dr??yk, Berenika; Ksi??opolska-Or?owska, Krystyna

2014-01-01

225

MRI findings of juvenile psoriatic arthritis  

Microsoft Academic Search

Objective  The aim of this study was to describe the magnetic resonance imaging (MRI) features of juvenile psoriatic arthritis (JpsA)\\u000a in children in order to facilitate early diagnosis and proper management.\\u000a \\u000a \\u000a \\u000a Materials and methods  Two pediatric radiologists retrospectively reviewed in consensus a total of 37 abnormal MRI examinations from 31 pediatric\\u000a patients (nine boys, 22 girls; age range 1–17 years; mean age 9.4 years)

Edward Y. Lee; Robert P. Sundel; Susan Kim; David Zurakowski; Paul K. Kleinman

2008-01-01

226

Airway obstruction and rheumatoid arthritis  

Microsoft Academic Search

The aim of this study was to assess the percentage of respiratory disorders and airway obstruction in patients with rheumatoid arthritis by com- paring lung function test results between patients with rheumatoid arthritis and control subjects with other rheumatological conditions. A prospective case-control study of respiratory symptoms and lung function abnormalities was performed in a series of 100 patients with

A. Vergnenègre; N. Pugnere; M. T. Antonini; M. Arnaud; B. Melloni; R. Treves; F. Bonnaud

1997-01-01

227

Classification of juvenile spondyloarthritis: enthesitis-related arthritis and beyond  

PubMed Central

Spondyloarthritis (SpA) refers to a spectrum of immune-mediated inflammatory diseases with overlapping features, which differ from other types of inflammatory arthritis in genetic predisposition, pathogenesis and outcome. SpA frequently involves the axial skeleton, and can result in abnormal bone formation with eventual ankylosis of the spine, resulting in substantial disability. SpA often begins as an ’undifferentiated’ disease, the presentation of which differs in children and adults; most notably, spinal involvement is uncommon, while hip arthritis and enthesitis are frequently seen in juvenile-onset disease. Currently, the classification of SpA in adults and children is approached differently. Using the International League of Associations for Rheumatology (ILAR) system for juvenile idiopathic arthritis, most childhood SpA is classified as enthesitis-related arthritis. However, in contrast to adult SpA classification, the presence of, or a family history of, psoriasis dictates a separate category of juvenile idiopathic arthritis. More importantly, the ILAR system does not specifically recognize the presence of axial disease in juvenile SpA. Resolution of these issues will improve communication and the transitioning of patients from pediatric to adult clinics, will facilitate research in genetics and pathogenesis, and will be particularly important in the evaluation of tumor necrosis factor inhibitors and other biologic agents for early, axial SpA. PMID:20606622

Colbert, Robert A.

2010-01-01

228

Accelerated development of arthritis in mice lacking endothelial selectins  

PubMed Central

The selectins, along with very late antigen-4 and CD44, have been implicated in mediating leukocyte rolling interactions that lead to joint recruitment and inflammation during the pathogenesis of rheumatoid arthritis. Previously, we showed that P-selectin deficiency in mice resulted in accelerated onset of joint inflammation in the murine collagen-immunized arthritis model. Here, we report that mice deficient either in E-selectin or in E-selectin and P-selectin (E/P-selectin mutant) also exhibit accelerated development of arthritis compared with wild type mice in the CIA model, suggesting that these adhesion molecules perform overlapping functions in regulating joint disease. Analyses of cytokine and chemokine expression in joint tissue from E/P-selectin mutant mice before the onset of joint swelling revealed significantly higher joint levels of macrophage inflammatory protein-1? and IL-1? compared to wild-type mice. IL-1? remained significantly increased in E/P-selectin mutant joint tissue during the early and chronic phases of arthritis. Overall, these data illustrate the novel finding that E-selectin and P-selectin expression can significantly influence cytokine and chemokine production in joint tissue, and suggest that these adhesion molecules play important regulatory roles in the development of arthritis in E/P-selectin mutant mice. PMID:16207337

Ruth, Jeffrey H; Amin, M Asif; Woods, James M; He, Xiaodong; Samuel, Sharon; Yi, Nengjun; Haas, Christian S; Koch, Alisa E; Bullard, Daniel C

2005-01-01

229

Evaluation of a highly specific functional test for the detection of factor V Leiden.  

PubMed

In the present study, a new functional test for the detection of increased resistance of coagulation factor V to degradation by activated protein C (factor V Leiden mutation) was evaluated. The STA-STACLOT APC-R Test (Diagnostica Stago, Asnieres, France) is based on the specific activation of factor X by Crotalus viridis helleri snake venom. The results are given as clotting time in seconds of the patient's plasma in the presence of venom and activated protein C. The intra-assay coefficient of variation was 2.17% (n=20) for samples within the normal range, and 1.70% and 1.42% (n=20) for the plasma of a heterozygous or a homozygous carrier of the factor V Leiden mutation, respectively. The inter-assay coefficient of variation (n=10) was 7.75% for the plasma of a healthy donor, 5.05% for the plasma of a heterozygous carrier and 3.38% for the plasma of a homozygous individual. The normal range (5th-95th percentile) of 136.4 s-174.7 s was derived from the clotting time of the plasma of 38 healthy controls. Values below 136 s were found in every sample from patients carrying the factor V Leiden mutation (n=52), whereas no patient with protein C (n=11) or protein S deficiency (n=10) had reduced clotting times. Homozygous carriers of the factor V Leiden mutation had clotting times shorter than 66.0 s and heterozygous carriers had clotting times longer than 80.0 s. Thus, based upon the individual clotting time, patients homozygous for factor V Leiden mutation could easily be distinguished from normals or heterozygous individuals. The influence of coagulation factor X, V, or II deficiency on the STACLOT APC-R Test was evaluated and revealed prolonged clotting times at factor V activities below 50%. In the presence of lupus anticoagulant the specificity of the STA-STACLOT APC-R Test was clearly decreased. In the present study, we clearly show that the STA-STACLOT APC-R Test is able to discriminate carriers of the factor V Leiden mutation from healthy controls or patients with protein C or protein S deficiency. PMID:11196068

Quenhenberger, P; Handler, S; Mannhalter, C; Pabinger-Fasching, I; Speiser, W

2000-01-01

230

Diagnosing and treating psoriatic arthritis: an update.  

PubMed

Psoriatic arthritis (PsA) is an inflammatory arthritis of uncertain pathogenesis, affecting approximately one in four patients with psoriasis. Onset of psoriasis typically precedes the development of PsA. Therefore, the dermatologist is ideally positioned to recognize the early signs and symptoms of PsA for diagnosis and subsequent treatment. The role of the dermatologist in early diagnosis and treatment is essential for preventing pain and functional disabilities, as well as the joint deterioration that accompanies progressive forms of PsA. Diagnosis of PsA is a key aspect of the clinical decision process for the dermatologist, as psoriasis plus PsA requires a different therapeutic approach from that required for psoriasis alone. Furthermore, PsA is associated with an increased risk of cardiovascular comorbidities that present significant health concerns. In this review, the pathogenesis and comorbidities of PsA are discussed. In addition, screening and imaging tools that aid in the diagnosis of PsA, as well as tools used for efficacy assessment, are reviewed. Available therapies are presented, with a focus on targeted biologics and emerging treatments. PMID:24266754

Boehncke, W H; Qureshi, A; Merola, J F; Thaçi, D; Krueger, G G; Walsh, J; Kim, N; Gottlieb, A B

2014-04-01

231

Psoriatic arthritis: recent progress in pathophysiology and drug development  

PubMed Central

Psoriatic arthritis (PsA) is the second most common inflammatory arthropathy, after rheumatoid arthritis diagnosis, in early arthritis clinics. Most patients have established psoriasis, often for years, prior to the onset of joint pain and swelling; in addition, associated features of nail disease, dactylitis, enthesitis, spondylitis or uveitis may be present. Psoriasis may not be immediately apparent, as small or patchy lesions may occur in the scalp or perineum. PsA presents as a symmetrical polyarthritis, similar to rheumatoid arthritis, or an asymmetrical oligoarthritis with a predilection for the distal interphalangeal joints. Spinal involvement is similar, although not identical, to ankylosing spondylitis. Joint damage occurs early; up to 50% of PsA patients have an 11% annual erosion rate in the first 2 years of disease duration, suggesting it is not a benign condition. There have been significant advances in our understanding of PsA pathogenesis in recent years, in the areas of genetics and molecular biology, implicating both the innate and the adaptive immune systems. This has lead to the introduction of evidence-based targeted therapy, primarily with tumour necrosis factor inhibitor (TNFi) agents. Therapy with disease-modifying anti-rheumatic drugs, such as methotrexate and leflunomide, remains the first-choice therapeutic intervention, even though there are few randomised controlled trials with these agents. In contrast, a number of successful studies of TNFi agents demonstrate excellent efficacy, in combination with methotrexate, and several novel agents are currently in development for the treatment of PsA. PMID:24611179

2013-01-01

232

Meta-analysis of factor V Leiden and prothrombin G20210A polymorphism in migraine.  

PubMed

Migraine is a frequent and disabling condition, which exhibits a substantial genetic background and is frequently associated with abnormalities of primary and secondary hemostasis. We performed a systematic literature search and a meta-analysis of available data about the potential associations between migraine and factor V (FV) Leiden or prothrombin (FII) G20210A gene polymorphism. The final number of studies included was 15 (all cross-sectional) about migraine and FV Leiden, and 12 (all cross-sectional) about migraine and FII G20210A polymorphism, with broad inter-study heterogeneity (I, 82 and 85%). The cumulative prevalence of the FV 1691A allele was found to be similar between cases (n?=?1450; 4.9%) and controls (n?=?3468; 4.7%; P?=?0.74). The cumulative prevalence of the FII 20210A allele was also found to be similar between cases (n?=?1226; 4.2%) and controls (n?=?3144; 4.5%; P?=?0.59). Nevertheless, sub-analysis of studies in adults and children revealed that both polymorphisms were not associated with migraine in adults, but FV Leiden and the FII 20210A allele were approximately two-fold more prevalent in children with migraine than in those without. In conclusion, despite migraine exhibits a clear neurovascular origin and is frequently associated with thrombotic disorders, isolate thrombophilic mutations seem to play a negligible pathogenetic role in this condition in adults, whereas the increased prevalence of FV Leiden and the FII 20210A allele in children with migraine deserves further scrutiny. PMID:25158985

Lippi, Giuseppe; Mattiuzzi, Camilla; Cervellin, Gianfranco

2015-01-01

233

From the Leiden jar to the discovery of the glass electrode by Max Cremer  

Microsoft Academic Search

The discovery of the glass electrode by Max Cremer was possible because of the advances made in the nineteenth century in\\u000a understanding the electrical properties of glass, and because of the studies of electrical potential drops at the interface\\u000a of phases. The discovery of the Leiden jar by E. G. von Kleist and the follow-up studies of the properties of

Fritz Scholz

2011-01-01

234

[Livedoid vasculopathy with heterozygous factor V Leiden mutation and sticky platelet syndrome].  

PubMed

A 64-year-old male patient presented with painful ulcerations and livedo racemosa of both lower limbs. He had a history of cerebral and myocardial infarctions. Dermatohistologic findings and laboratory tests of the patient's coagulation system revealed the diagnosis of livedoid vasculopathy with heterozygous factor V Leiden mutation and sticky platelet syndrome type II. Systemic treatment with acetylsalicylic acid and heparin as well as topical therapy with disinfectant and granulation-inducing agents resulted in improvement of the skin lesions. PMID:15021932

Lewerenz, V; Burchardt, T; Büchau, A; Ruzicka, T; Megahed, M

2004-04-01

235

Factor V Leiden, prothrombin 20210A, methylenetetrahydrofolate reductase 677T, and population genetics  

Microsoft Academic Search

Thrombosis results from the interaction between predisposing genetic polymorphisms and acquired risk factors. Two of the main prothrombotic alleles, Factor V (FV) Leiden and prothrombin 20210A, are only encountered among European populations. They are estimated to have arisen about 21,000–34,000 years ago as founding mutations after the evolutionary divergence of Caucasians from Asians, and have been subsequently dispersed by the

F. Bauduer; D. Lacombe

2005-01-01

236

Prevalence of factor V Leiden mutation in non-European populations.  

PubMed

A difference in the prevalence of venous thromboembolism (TE) in major human groups has been described and an uneven distribution of FV Leiden mutation over the world has recently been reported. We investigated FV Leiden mutation in 584 apparently healthy subjects mostly from populations different from those previously investigated: 170 Europeans (Spanish, Italians), 101 sub-saharan Africans (Fon, Bariba, Berba, Dendi), 115 Asians (Indonesians, Chinese, Tharus), 57 Amerindians (Cayapa), 84 Afroamericans (Rio Cayapa, Viche), and 57 Ethiopians (Amhara, Oromo). The mutation was detected in only 1/115 Asian (Tharu) and in 5/170 Europeans (4 Italians, 1 Spanish). These data confirm that in non-Europeans the prevalence of FV mutation is at least 7 times lower than in Europeans and provide indirect evidence of a low prevalence not only of the FV Leiden gene but also of other genes leading to more severe thrombophilia. Finally, findings from the literature together with those pertaining to this study clearly show a marked heterogeneity among Europeans. PMID:9157591

Pepe, G; Rickards, O; Vanegas, O C; Brunelli, T; Gori, A M; Giusti, B; Attanasio, M; Prisco, D; Gensini, G F; Abbate, R

1997-02-01

237

Prothrombin G20210A and factor V Leiden polymorphisms in stroke.  

PubMed

The molecular epidemiology of stroke is critically lacking in the developing world. We explored the relationships between genetics polymorphism and risk for ischemic stroke among the residents of Casablanca, Morocco. Ninety-one stroke patients matched 1:2 for their age, gender, and ethnic background to 182 healthy controls who were genotyped for the prothrombin G20210A mutation and factor V (FV) Leiden and were assessed for conventional risk factors for stroke. No significant association was found between prothrombin gene mutation with stroke (p?=?.054). Regarding stroke subtypes, significant relationships between patients with a large artery disease subtype of stroke and this mutation was found compared to controls (p?=?.046). As a genetic risk factor to develop this event, a strong association was observed when adjusted for conventional vascular risk factors (adjusted OR, 4.3; p?=?.029). No FV Leiden was found. We suggest that prothrombin mutation but not FV Leiden should be considered as a modest genetic risk factor for large artery disease stroke subtype in the Moroccan population. PMID:21701789

They-They, Thierry Paluku; Battas, Omar; Slassi, Ilham; Rafai, Mohamed Abdou; Katumbay, Desire Tshala; Nadifi, Sellama

2012-01-01

238

[Septic arthritis in adults].  

PubMed

Septic arthritis is a true rheumatological emergency requiring immediate and thoughtful effort for rapid diagnosis establishment and treatment initiation. Children and elderly persons as well as immunocompromised individuals, patients with pre-existing joint damage and with inflammatory rheumatic joint diseases are preferentially affected. Bacteremia, joint surgery and intra-articular injections pose risk situations for the development of joint infections. The most frequent causative organism is Staphylococcus aureus but other relevant pathogens include coagulase-negative staphylococci, streptococci and mycobacteria. Synovial fluid analysis (e.g. appearance, cell count and microbiological examination) is the most important step to establish the diagnosis. The two main components of therapy consist of joint drainage and antibiotic treatment. The approach to periprosthetic joint infections depends on the duration of symptoms, causative organism and individual factors. PMID:25115141

Loock, J; Haustedt, N; Wollenhaupt, J

2014-09-01

239

Certolizumab for rheumatoid arthritis.  

PubMed

This is a review of the pharmacology of certolizumab pegol and its efficacy and safety in the treatment of patients with rheumatoid arthritis refractory to synthetic disease-modifying anti-rheumatic drugs (DMARDs). Certolizumab is a new anti-TNF-? biologic agent injected subcutaneously with an innovative molecular structure and unique pharmacodynamic and pharmacokinetic properties. Data from controlled clinical trials indicate that the drug is effective in reducing disease activity and disability. It also inhibits radiographic progression. Certolizumab administration has an acceptable safety profile. The clinical data available suggest that the nature of adverse events is generally comparable to that of other TNF-? blockers. Given its rapid onset of action certolizumab presents an attractive alternative therapeutic option for patients with moderate to severe RA refractory to DMARDs. PMID:24447441

Markatseli, T E; Papagoras, C; Nikoli, A; Voulgari, P V; Drosos, A A

2014-01-01

240

[Morphology of psoriatic arthritis].  

PubMed

Twenty-four biopsies of the synovial membrane, 8 biopsies of the cartilage and 8 samples of the synovial liquid from the knee joint were studied histologically, histochemically and by the immunofluorescent method. Proliferation, degeneration and desquamation of the synovial layer, localization of the inflammatory process in the superficial subsynovial layer, polynuclears in the inflammatory exudate, annular vascular sclerosis in the deep parts of the synovial villi are distinct features of psoriatic synovitis. The evidence for the involvement of humoral and cell immunity factors in the pathogenesis of the disease are obtained by means of immunological and immunofluorescent methods. On the basis of clinicomorphological data psoriatic arthritis is regarded as an independent nosological variety of the joint disease. PMID:4051805

Kop'eva, T N; Agababova, E R; Trushina, L S; Artem'eva, L S

1985-01-01

241

Smoking and Rheumatoid Arthritis  

PubMed Central

Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by both genetic and environmental factors. Smoking has been implicated as one of the most important extrinsic risk factors for its development and severity. Recent developments have shed light on the pathophysiology of RA in smokers, including oxidative stress, inflammation, autoantibody formation and epigenetic changes. The association of smoking and the development of RA have been demonstrated through epidemiologic studies, as well as through in vivo and animal models of RA. With increased use of biological agents in addition to standard disease-modifying antirheumatic drugs (DMARDs), there has been interest in how smoking affects drug response in RA treatment. Recent evidence suggests the response and drug survival in people treated with anti-tumour necrosis factor (anti-TNF) therapy is poorer in heavy smokers, and possible immunological mechanisms for this effect are presented in the current paper. PMID:25479074

Chang, Kathleen; Yang, So Min; Kim, Seong Heon; Han, Kyoung Hee; Park, Se Jin; Shin, Jae Il

2014-01-01

242

Interferon ? -induced chemokines in psoriatic arthritis.  

PubMed

Interferon ?-inducible protein (IP-10) chemokine is implicated in the pathogenesis of psoriatic arthritis (PsA). It was shown that chemokine (C-X-C motif) receptor (CXCR) 3 and CXCR4 were expressed by both blood-derived plasmacytoid dendritic cells (pDCs) and pDCs isolated from rheumatoid arthritis (RA) and PsA synovial fluid (SF) and that IP-10, chemokine (C-X-C motif) ligand (CXCL)-11, and CXCL-12 present in RA and PA SF stimulated chemotaxis of blood-derived pDCs. High circulating levels of IP-10 and chemokine (C-C motif) ligand (CCL) 2 have been found in PsA patients, with a T helper cells (Th) 1 immune predominance in the early phase of the disease. Moreover a decline of IP-10 levels has been observed in long lasting PsA, with a significant increase of the CCL2/IP-10 ratio, suggesting a shift from Th1 to Th2 immune response in long duration PsA. IP-10 levels in PsA patients are significantly higher in presence of autoimmune thyroiditis. IP-10 has been suggested to be a good marker to monitor the activity or progression of PsA. Attempts have been made to modulate or inhibit the production of IP-10 in PsA in order to modify the course of the disease. PMID:25524203

Devito, A

2014-01-01

243

Drug therapy for juvenile arthritis.  

PubMed

Juvenile arthritis includes a variety of rheumatic disorders with varied articular and extraarticular manifestations. The heterogeneity of JA cannot be overemphasized in a rational approach to therapy. Fortunately, most children with JA improve significantly with first-line treatment, especially those with pauciarticular disease. Only a small number of these patients go on to require second-line treatment, usually because of the evolution of their condition into the polyarticular type. Patients with polyarticular, RF-positive disease and patients with early-onset polyarthritis in association with systemic-onset disease both have poor prognoses in terms of ultimate joint function, and should receive second-line treatment early in their therapy. Injectable gold is the drug of choice for the former patients, if an initial trial of NSAIDs has failed. Patients with polyarticular onset, RF-negative disease generally have a better prognosis than other patients with polyarticular involvement. One may wait considerably longer before introducing a second-line agent for these patients. An antimalarial agent may be a reasonable choice for these patients, especially those with limited polyarticular involvement (5 to 10 active joints). This latter principle may also be applied to patients who evolve from pauciarticular to polyarticular involvement. In all such cases, penicillamine is almost never used as first choice. If the patient is a young child, the difficulty with injecting gold and the hazards of antimalarial agents may limit the use of these treatments. In situations such as this, auranofin or sulfasalazine may be the drug of choice. Cytotoxic/antimetabolic therapy should be reserved for those children who have continued active disease despite full courses of two SAARDs, or for those who have been unable to take SAARDs because of their side effects. Corticosteroid therapy should be used only when specifically indicated, and every attempt should be made to wean the patient from it as soon as feasible. The aim of therapy is to ensure that patients enter their remission in the best condition possible. For this to be assured, a sensible approach to drug therapy is mandatory. PMID:2572375

Duffy, C M; Laxer, R M; Silverman, E D

1989-10-01

244

Burden of childhood-onset arthritis  

Microsoft Academic Search

Juvenile arthritis comprises a variety of chronic inflammatory diseases causing erosive arthritis in children, often progressing to disability. These children experience functional impairment due to joint and back pain, heel pain, swelling of joints and morning stiffness, contractures, pain, and anterior uveitis leading to blindness. As children who have juvenile arthritis reach adulthood, they face possible continuing disease activity, medication-associated

Lakshmi N Moorthy; Margaret GE Peterson; Afton L Hassett; Thomas JA Lehman

2010-01-01

245

Septic Arthritis of the Shoulder Complicating Pregnancy  

PubMed Central

Septic arthropathy leads to rapid joint destruction, impairment, and disability. Staphylococcus can be particularly virulent to bone and joints leading to adverse obstetric events. At 28 of weeks gestation, a patient presented with pyelonephritis and progressive left shoulder pain. Magnetic resonance imaging indicated early clavicular destruction and acromial involvement. Glenohumeral joint aspiration produced Staphylococcus aureus. The patient then had premature rupture of membranes and progressed rapidly to preterm delivery. Placental pathology revealed chorioamnionitis and microabscesses. Treatment of the infected joint required further surgical drainage and bone resection as well as extended antibiotics. It is important to remember that joint pain in pregnancy may indicate infective arthritis, and pyelonephritis can be a source of such an infection. Evaluation includes magnetic resonance imaging and consultation for joint aspiration. Prompt recognition and treatment are necessary to prevent joint destruction. PMID:24959364

Raiser, Sara; Davidson, Kathryn; Walsh, Ashley; Egerman, Robert

2014-01-01

246

Association of Prothrombin (A20210G) and Factor V Leiden (A506G) with Recurrent Pregnancy Loss  

PubMed Central

ABSTRACT Background: Inherited thrombophilias are the leading cause of maternal thromboembolism and are associated with an increased risk of recurrent spontaneous abortion (second- and third-trimester fetal loss). The purpose of this study was to investigate the effects of factor V and factor II involved in reproductive failure. Recently a possible association between unexplained infertility and genetic thrombophilia gene mutations have been reported with a significant statistically association with prothrombin A20210G. Materials and Methods: During the period from January 2011 to December 2011, 283 patients with unexplained infertility, who had received in our hospital, were investigated for this retrospective study, and the frequency of polymorphic variations was calculated. The infertile couples with recurrent pregnancy loss (RPL), had been trying to achieve successful pregnancy for greater than 1 year without success and known causes of infertility were excluded (semen anomalies, karyotype abnormalities, uterine malformations, etc) referred to our Centre for genetic counseling. The control group consists of 100 women who had one or more children in history were investigated by DNA Strip. Results: Heterozygous and normal homozygous for the factor V mutation and factor II mutation were equally distributed among patients with recurrent miscarriage and fertile patients with two or more previous births. The combination of the two polymorphisms, prothrombin (A20210G) and factor V Leiden (A506G) revealed a significant correlation between them and early fetal loss. Conclusions: The genes involved in thrombophilia could be one reason for fertility complications in some women with unexplained infertility. Our study shows that there is an association between factor II and V mutation and the risk for fetal loss. PMID:23400304

MIERLA, Dana; SZMAL, Camelia; NEAGOS, Daniela; CRETU, Ruxandra; STOIAN, Veronica; JARDAN, Dumitru

2012-01-01

247

Detection of rheumatoid arthritis using infrared imaging  

NASA Astrophysics Data System (ADS)

Rheumatoid arthritis (RA) is an inflammatory disease causing pain, swelling, stiffness, and loss of function in joints; it is difficult to diagnose in early stages. An early diagnosis and treatment can delay the onset of severe disability. Infrared (IR) imaging offers a potential approach to detect changes in degree of inflammation. In 18 normal subjects and 13 patients diagnosed with Rheumatoid Arthritis (RA), thermal images were collected from joints of hands, wrists, palms, and knees. Regions of interest (ROIs) were manually selected from all subjects and all parts imaged. For each subject, values were calculated from the temperature measurements: Mode/Max, Median/Max, Min/Max, Variance, Max-Min, (Mode-Mean), and Mean/Min. The data sets did not have a normal distribution, therefore non parametric tests (Kruskal-Wallis and Ranksum) were applied to assess if the data from the control group and the patient group were significantly different. Results indicate that: (i) thermal images can be detected on patients with the disease; (ii) the best joints to image are the metacarpophalangeal joints of the 2nd and 3rd fingers and the knees; the difference between the two groups was significant at the 0.05 level; (iii) the best calculations to differentiate between normal subjects and patients with RA are the Mode/Max, Variance, and Max-Min. We concluded that it is possible to reliably detect RA in patients using IR imaging. Future work will include a prospective study of normal subjects and patients that will compare IR results with Magnetic Resonance (MR) analysis.

Frize, Monique; Adéa, Cynthia; Payeur, Pierre; Di Primio, Gina; Karsh, Jacob; Ogungbemile, Abiola

2011-03-01

248

HELLP Syndrome and Cerebral Venous Sinus Thrombosis Associated with Factor V Leiden Mutation during Pregnancy.  

PubMed

Preeclampsia is a leading cause of maternal mortality and morbidity worldwide. The neurological complications of preeclampsia and eclampsia are responsible for a major proportion of the morbidity and mortality for women and their infants alike. Hormonal changes during pregnancy and the puerperium carry an increased risk of venous thromboembolism including cerebral venous sinus thrombosis (CVST). Factor 5 leiden (FVL) is a procoagulant mutation associated primarily with venous thrombosis and pregnancy complications. We report a patient with FVL mutation who presented with CVST at 24th week of pregnancy and was diagnosed as HELLP syndrome at 34th week of pregnancy. PMID:25317347

Dag, Zeynep Ozcan; I?ik, Yuksel; Simsek, Yavuz; Tulmac, Ozlem Banu; Demiray, Demet

2014-01-01

249

HELLP Syndrome and Cerebral Venous Sinus Thrombosis Associated with Factor V Leiden Mutation during Pregnancy  

PubMed Central

Preeclampsia is a leading cause of maternal mortality and morbidity worldwide. The neurological complications of preeclampsia and eclampsia are responsible for a major proportion of the morbidity and mortality for women and their infants alike. Hormonal changes during pregnancy and the puerperium carry an increased risk of venous thromboembolism including cerebral venous sinus thrombosis (CVST). Factor 5 leiden (FVL) is a procoagulant mutation associated primarily with venous thrombosis and pregnancy complications. We report a patient with FVL mutation who presented with CVST at 24th week of pregnancy and was diagnosed as HELLP syndrome at 34th week of pregnancy. PMID:25317347

Dag, Zeynep Ozcan; I?ik, Yuksel; Simsek, Yavuz; Tulmac, Ozlem Banu; Demiray, Demet

2014-01-01

250

A case of livedoid vasculopathy associated with factor V Leiden mutation: successful treatment with oral warfarin.  

PubMed

Livedoid vasculopathy is characterized by painful purpuric lesions on the extremities which frequently ulcerate and heal with atrophic scarring. It has been considered to be a vasculitic process but now there has been increasing evidence that abnormal coagulation plays a major role in the pathogenesis of this rare disorder. We report the case of a 19-year-old male who had been suffering from recurrent painful ulcerations on both lower legs with atrophic scars for 4 years. A biopsy specimen revealed vasculopathy, and laboratory studies showed resistance to activated protein C with factor V Leiden mutation. Treatment with oral warfarin led to rapid improvement of the lesions. PMID:18484430

Kavala, Mukaddes; Kocaturk, Emek; Zindanci, Ilkin; Turkoglu, Zafer; Altintas, Sumeyye

2008-01-01

251

Livedoid vasculiltis associated with a double heterozygous Factor V Leiden and prothrombin G20210A gene mutations.  

PubMed

Livedoid vasculitis (LV) may be an isolated condition or associated with an underlying systemic disease, including coagulation disorders, periarteritis nodosa and systemic autoimmune diseases. The classic histological features of LV (fibrin deposition on dermal vessels and the absence of important perivascular infiltrate or leucocytoclasia) argue against a primary vasculitis and is more in keeping with a thrombotic process. Factor V Leiden mutations have rarely been reported in association with LV. We report a patient with LV, who had doubly inherited thrombophilia, with heterozygous mutations in the Factor V Leiden (G1691A) and prothrombin (G20210A) genes. PMID:19793098

Khenifer, S; Thomas, L; Balme, B; Dalle, S

2009-12-01

252

Organising pneumonia as the first manifestation of rheumatoid arthritis  

PubMed Central

Organising pneumonia (OP) is an inflammatory lung disease with distinctive clinicopathological features. OP can be evident during the course of rheumatoid arthritis (RA) with increased disease activity. The authors report an OP associated with RA case in which pulmonary symptoms preceded the onset of joint symptoms. An OP patient with elevated serum anticyclic citrullinated peptide antibody is likely to manifest RA in the near future, reflecting its high disease activity. Thus, an early rheumatologic consultation should be taken into consideration to make an early decision to initiate disease-modifying antirheumatic drugs therapy. PMID:22699479

Hoshino, Chisho; Satoh, Noriyuki; Narita, Masashi; Kikuchi, Akio; Inoue, Minoru

2011-01-01

253

Organising pneumonia as the first manifestation of rheumatoid arthritis.  

PubMed

Organising pneumonia (OP) is an inflammatory lung disease with distinctive clinicopathological features. OP can be evident during the course of rheumatoid arthritis (RA) with increased disease activity. The authors report an OP associated with RA case in which pulmonary symptoms preceded the onset of joint symptoms. An OP patient with elevated serum anticyclic citrullinated peptide antibody is likely to manifest RA in the near future, reflecting its high disease activity. Thus, an early rheumatologic consultation should be taken into consideration to make an early decision to initiate disease-modifying antirheumatic drugs therapy. PMID:22699479

Hoshino, Chisho; Satoh, Noriyuki; Narita, Masashi; Kikuchi, Akio; Inoue, Minoru

2011-01-01

254

Current evidence for the management of rheumatoid arthritis with glucocorticoids: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis  

Microsoft Academic Search

Glucocorticoids (GCs) rapidly reduce disease activity in early and advanced rheumatoid arthritis (RA). This systematic review on behalf of the task force on recommendations for the management of RA addresses the efficacy of GCs in RA. A literature search was performed in Medline, Embase, the Cochrane database, and the ACR\\/EULAR abstracts 2007 and 2008 on a set of questions relating

S. L. Gorter; Johannes W Bijlsma; M. Cutolo; J. Gomez-Reino; M. Kouloumas; J. S. Smolen; R. Landewe

2010-01-01

255

Treatment of arthritis, including rheumatoid arthritis, with radioactive isotopes  

SciTech Connect

A radioactive composition is described for the treatment of arthritis comprising, in combination, a ferric hydroxide or aluminum hydroxide aggregate suspension having a particle size of 3 to 20 microns, wherein a radionuclide is entrapped, the radionuclide being /sup 166/Holmium.

Lieberman, E.; Bordoni, M.E.; Thornton, A.K.

1988-06-21

256

Avian viral arthritis as a model for rheumatoid arthritis: a gross, histologic, and immunofluorescent study of experimentally induced viral arthritis in chickens  

E-print Network

in arthritis of unknown etiology (29). The discovery of hepatitis-associated antigen has increased interest in viral hepatitis arthritis as a potential model of arthritis induced by complexes of viral-associated antigen and antibody (29). The clinical case...AVIAN VIRAL ARTHRITIS AS A MODEL FOR RHEUMATOID ARTHRITIS-, - A GROSS, HISTOLOGIC, AND IMMUNOFLUORESCENT STUDY OF EXPERIMENTALLY INDUCED VIRAL ARTHRITIS IN CHICKENS A Thesis by SUSAN EMMAGENE WILSON Submitted to the Graduate College of Texas...

Wilson, Susan Emmagene

1976-01-01

257

Advances in the management of psoriatic arthritis.  

PubMed

Psoriatic arthritis (PsA), which affects musculoskeletal structures, skin and nails, is a heterogeneous chronic inflammatory disease with a wide clinical spectrum and variable course. Patients with PsA are more likely than healthy individuals to have metabolic syndrome or cardiovascular disease. To include these comorbidities, 'psoriatic disease' has been suggested as an umbrella term. The management of PsA has changed tremendously over the past decade owing to early diagnosis and improvement in treatment strategies, including, early referral from dermatologists and primary-care physicians to rheumatologists, early initiation of therapy, treating to the target of remission or low disease activity, and advances in pharmacological therapy. Outcome assessment is also improving, because of validated instruments for clinical disease manifestations. The commercialization of TNF blockers, including adalimumab, etanercept, golimumab and infliximab, is representative of a revolution in the treatment of PsA. A new anti-TNF agent, certolizumab pegol, and a fully human monoclonal antibody against IL-12 and IL-23, ustekinumab, are approved for the treatment of active PsA. The efficacy of ustekinumab suggests that inhibiting the type 17 T helper pathway might be an alternative to blocking TNF. PsA management must now use improved measures to predict patient outcomes and define remission, and develop better-targeted therapies. PMID:25003762

Olivieri, Ignazio; D'Angelo, Salvatore; Palazzi, Carlo; Padula, Angela

2014-09-01

258

Detection of factor V Leiden by PCR-SSCP using GMA precast Elchrom scientific gels.  

PubMed

Genetic abnormalities in hemostatic proteins associated with hypercoagulability are an important hereditary risk factor for venous thrombosis. Several genetic mutations that cause hereditary disorders predisposing to thrombosis have been described, point mutation in the coagulation factor V gene (FV:R506Q), called factor V Leiden, being the most common of them. A new inexpensive and simple polymerase chain reaction-single-strand polymorphism (PCR-SSCP) based method for detection of this genetic abnormality is reported. The study population consisted of 150 subjects whose factor V genotype was previously determined by PCR-RFLP method using the Mnl I restriction endonuclease. A 223-bp fragment containing the G1692-A (Arg 506-Gln) polymorphic site in exon 10 of the factor V gene was amplified, denatured, and run overnight on the commercially available GMA gels for SSCP. PCR-SSCP analysis showed reproducible and uniform band patterns for FV mutant and wild type alleles. Furthermore, PCR-SSCP results were consistent with those obtained with PCR-RFLP analysis (100%). The described PCR-SSCP procedure is reliable, time-saving, and cost-effective. The method may be considered as a potentially powerful new tool in the routine detection of factor V Leiden. PMID:14507111

Simundic, Ana-Maria; Topic, Elizabeta; Stefanovic, Mario

2003-07-01

259

Transferrin microheterogeneity in rheumatoid arthritis  

Microsoft Academic Search

We studied the relation between disease activity in rheumatoid arthritis (RA) and the microheterogeneity of transferrin. Using crossed immuno isoelectric focusing, transferrin microheterogeneity patterns were analyzed in sera of healthy individuals, nonanemic RA patients, iron deficient RA patients and RA patients with the anemia of chronic disease (ACD). In all RA groups a significant shift in the microheterogeneity pattern was

R. A. Feelders; G. Vreugdenhil; G. Jong; A. J. G. Swaak; H. G. Eijk

1992-01-01

260

Follistatin-Like Protein 1 Promotes Arthritis by Up-Regulating IFN-?1  

PubMed Central

Follistatin-like protein-1 (FSTL-1) is a poorly characterized protein that is up-regulated in the early stage of collagen-induced arthritis and that exacerbates arthritis when delivered by gene transfer. The current study was designed to determine the mechanism by which FSTL-1 promotes arthritis. FSTL-1 was injected into mouse paws, resulting in severe paw swelling associated with up-regulation of IFN-? transcript and the IFN-?-induced chemokine, CXCL10. Mice depleted of T cells were protected. A central role for IFN-? was confirmed by the finding that mice deficient in IFN-? failed to exhibit paw swelling in response to injection of FSTL-1. Furthermore, IFN-? secretion from mouse spleen cells exposed to a weak TCR signal was increased 5-fold in the presence of FSTL-1. FSTL-1 could be induced by innate immune signals, including TLR4 agonists and the arthritogenic cytokine, IL-1?, via an NF?B pathway. Finally, FSTL-1 was found to be overexpressed in human arthritis and its neutralization inhibited murine collagen-induced arthritis and suppressed IFN-? and CXCL10 production in arthritic joints. These findings demonstrate that FSTL-1 plays a critical role in arthritis by enhancing IFN-? signaling pathways and suggest a mechanism by which FSTL-1 bridges innate and adaptive immune responses. PMID:19109154

Clutter, Suzanne D.; Wilson, David C.; Marinov, Anthony D.; Hirsch, Raphael

2011-01-01

261

The role of plasminogen activator inhibitor-1 polymorphism, factor-V-Leiden, and prothrombin-20210 mutations in pulmonary thromboembolism.  

PubMed

Polymorphism in plasminogen activator inhibitor-1 gene is suggested to be associated with an increased risk of venous thromboembolism. The aim of this study was to investigate the association of plasminogen activator inhibitor-1 gene polymorphism and its coexistence with factor-V-Leiden and prothrombin-20210 mutations in pulmonary thromboembolism. The authors investigated plasminogen activator inhibitor-1 4G/5G polymorphism, factor-V-Leiden, and prothrombin-20210 mutations in 143 pulmonary thromboembolism patients and 181 controls. Plasminogen activator inhibitor-1 4G/4G, 4G/5G, and 5G/5G gene polymorphisms and prothrombin-20210 mutations were not different between cases and controls. Factor-V-Leiden mutation was present in 21.0% and 7.7% of the cases and controls, respectively, P = .001. Neither different plasminogen activator inhibitor-1 genotypes and 4G allele nor coexistence of the allele with factor-V-Leiden or prothrombin-20210 was associated with the risk of recurrence. As a result, plasminogen activator inhibitor-1 gene polymorphism or its concomitant presence with mentioned mutations was not found to be associated with increased risk for pulmonary thromboembolism or recurrent disease in this study. PMID:18160588

Oguzulgen, I Kivilcim; Yilmaz, E; Demirtas, Senay; Erkekol, Ferda Oner; Ekim, Numan; Demir, Nalan; Numanoglu, Numan; Ozel, Duygu; Ulu, Arzu; Akar, Nejat

2009-02-01

262

Race and other risk markers in juvenile idiopathic arthritis-associated uveitis in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry  

PubMed Central

OBJECTIVES To characterize the epidemiology and clinical course of children with juvenile idiopathic arthritis-associated uveitis (JIA-U) in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry and explore differences between African American (AA) and Non-Hispanic White (NHW) children. METHODS There were 3,967 NHW and AA children with JIA enrolled in the CARRA Registry. Demographic and disease-related data were collected from time of diagnosis to enrollment. Children with JIA alone were compared to those with JIA-U. Children with JIA-U were then compared by race. RESULTS Mean age of children with JIA-U was 11.4 years (±4.5), 76.9% were female and 2.8% were AA. Children with JIA-U were younger at arthritis onset, female, required more medications, had <5 joints involved, had oligoarticular JIA, and ANA (+), RF (?) and anti-CCP (?). AA children with JIA-U had decreased uveitis frequency, were older at arthritis onset and more frequently diagnosed with enthesitis-related JIA. Predictors of uveitis development include female gender, early age of arthritis onset, and oligoarticular persistent and extended JIA classification, whereas polyarticular RF-positive JIA was protective. CONCLUSIONS The prevalence of JIA-U in AA and NHW children is 11.6% in the CARRA registry. Known risk markers (ANA, age at arthritis onset, and oligoarticular JIA) were more frequent in our JIA-U cohort. AA children had a lower frequency of JIA-U. There were significant differences in age of arthritis onset and JIA subtype between NHW and AA children, although the ANA, RF and HLA-B27 were similar. Exploration of race as a risk factor should be considered. PMID:24187099

Angeles-Han, Sheila T.; Pelajo, Christina F.; Vogler, Larry B.; Rouster-Stevens, Kelly; Kennedy, Christine; Ponder, Lori; McCracken, Courtney; Lopez-Benitez, Jorge; Drews-Botsch, Carolyn; Prahalad, Sampath

2014-01-01

263

77 FR 14529 - Arthritis Advisory Committee; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...FDA-2012-N-0001] Arthritis Advisory Committee...Name of Committee: Arthritis Advisory Committee...Pfizer Inc., for the treatment of adult patients with...moderately to severely active rheumatoid arthritis who have had an...

2012-03-12

264

Epidemiology of Rheumatoid Arthritis: Rheumatoid Arthritis and Mortality  

Microsoft Academic Search

Increased mortality in rheumatoid arthritis (RA) is widely recognized but not fully explained. Despite substantial improvements\\u000a in management and growing knowledge of the determinants of increased mortality, evidence for reduction in mortality in RA\\u000a has lagged behind. Indeed, most studies report no apparent reduction in mortality in RA. However, emerging evidence from some\\u000a recent RA inception cohorts suggests no increased

Elena Myasoedova; John M. Davis; Cynthia S. Crowson; Sherine E. Gabriel

2010-01-01

265

Heat shock proteins and reactive arthritis  

Microsoft Academic Search

\\u000a Reactive arthritis (ReA) is unusual amongst inflammatory joint diseases because the cause of arthritis has been identified,\\u000a namely preceding infection with certain bacteria, whereas the aetiology of rheumatoid arthritis or ankylosing spondylitis,\\u000a or at least the triggering event, remains unknown. Most subjects infected by Chlamydia,Salmonella, Campylobacter,Yersinia or Shigella develop symptoms due to the effects of the infection in the genito-urinary

J. S. Hill Gaston; Richard C. Duggleby; Jane C. Goodall; Roberto Raggiaschi; Mark S. Lillicrap

266

The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis  

Microsoft Academic Search

ABSTRACT: The presence or absence of antibodies to citrullinated peptides\\/proteins (ACPA) is an important parameter that helps a clinician set a diagnosis of early rheumatoid arthritis and, hence, initiate treatment. There are several commercial tests available to measure ACPA levels, although it can be difficult to decide what the best test for a given clinical question is. We analyzed literature

Ger JM Pruijn; Allan Wiik; Walther J van Venrooij

2010-01-01

267

Bilateral septic knee arthritis after treatment of an ectopic pregnancy with methotrexate  

PubMed Central

We describe a case of bilateral septic knee arthritis that followed the administration of methotrexate for nonsurgical termination of an ectopic pregnancy. We believe that methotrexate is a relatively effective alternative to surgery in patients with early unruptured tubal pregnancies, but suggest that it be used with caution in view of possible septic events. PMID:25610005

Karaaslan, Fatih; Mermerkaya, Musa U?ur; Yurdakul, Emre; Tan?n, Özlem

2015-01-01

268

Microbial Infection and Rheumatoid Arthritis  

PubMed Central

Rheumatoid arthritis (RA) is a complex autoimmune disease affecting 1–2% of general worldwide population. The etiopathogenesis of RA involves the interplay of multiple genetic risk factors and environmental triggers. Microbial infections are believed to play an important role in the initiation and perpetuation of RA. Recent clinical studies have shown the association of microbial infections with RA. Accumulated studies using animal models have also found that microbial infections can induce and/or exaggerate the symptoms of experimental arthritis. In this review, we have identified the most common microbial infections associated with RA in the literature and summarized the current evidence supporting their pathogenic role in RA. We also discussed the potential mechanisms whereby infection may promote the development of RA, such as generation of neo-autoantigens, induction of loss of tolerance by molecular mimicry, and bystander activation of the immune system. PMID:25133066

Li, Song; Yu, Yangsheng; Yue, Yinshi; Zhang, Zhixin; Su, Kaihong

2014-01-01

269

Juvenile Psoriatic Arthritis (JPsA): juvenile arthritis with psoriasis?  

PubMed Central

Background Following the introduction of the ILAR criteria for juvenile idiopathic arthritis, juvenile psoriatic arthritis (JPsA) has become a better recognized category within the inflammatory arthritides of childhood.?There are fewer reports describing the characteristics and long-term outcome of patients with JPsA than other subtypes of JIA. The aim of our study was to determine the long-term outcome and clinical course of patients with juvenile psoriatic arthritis (JPsA) and to define subgroups of JPsA. Methods Clinical records of all patients meeting criteria for JPsA were reviewed and divided into 4 groups depending on their clinical features and onset type. Patient characteristics and clinical features at onset and during follow-up were determined. Results The cohort consisted of 119 patients: 65 with oligoarticular-onset (55%; persistent 44 and extended 21), 34 (29%) with RF(-) and 4 (3%) RF(+) polyarticular and 16 (13%) enthesitis-related arthritis (ERA). At diagnosis patients with ERA were oldest and more commonly male (p=0.001 and =0.01 respectively). Patients with a polyarticular course had more involvement of small joints of the hands and wrist when compared to patients with persistent oligoarticular and ERA (p<0.001) while patients with ERA had more hip and sacroiliac arthritis (p<0.001 for both). Nail changes were seen in 66 patients (57%) and were associated with DIP involvement (p=0.0034). Outcome: Time to first inactive disease on, but not off, therapy was significantly longer among patients with polyarticular course when compared to oligoarticular and ERA (p=0.016 and p=0.48 respectively). Patients with polyarticular course more frequently had contractures during follow-up than other groups (p=0.01). Conclusion The long-term outcome of with JPsA was generally good. Patients with JPsA did not appear to form distinct sub-group of patients but rather resembled JIA patients with onset types without psoriasis. PMID:23497068

2013-01-01

270

Rheumatoid arthritis and periodontal disease  

Microsoft Academic Search

The prevalence of periodontal disease has increased two-fold among patients with rheumatoid arthritis (RA) compared to the general population. This increased prevalence is unrelated to secondary Sjögren's syndrome but instead reflects shared pathogenic mechanisms, including an increased prevalence of the shared epitope HLA-DRB1-04; exacerbated T-cell responsiveness with high tissue levels of IL-17; exaggerated B-cell responses, with plasma cells being the

Jean-Marie Berthelot; Benoît Le Goff

2010-01-01

271

Pulmonary involvement in rheumatoid arthritis  

Microsoft Academic Search

The primary objective of this investigation was to assess the relationships between clinical characteristics, lung involvement, and frequency of pulmonary involvement in rheumatoid arthritis (RA). Using high-resolution computed tomography (HRCT) and pulmonary function tests (PFT), we prospectively evaluated 52 patients with RA (eight males and 44 females, mean age 53.6 years). The HRCT was abnormal in 35 patients (67.3%), the most

Ayhan Bilgici; H. Ulusoy; O. Kuru; Ç. Çelenk; M. Ünsal; M. Danac?

2005-01-01

272

Morphologic alterations of the subchondral bone in advanced degenerative arthritis.  

PubMed

A series of 535 femoral heads surgically excised at the time of total hip arthroplasty for degenerative arthritis were analyzed by gross photography, specimen roentgenograms, and whole-mount histologic sections. Limited regenerative capacity was apparent in the chondrous tufts in the exposed bone of the osteoarthritic joint surface. The mechanism for the formation of subchondral cysts was interpreted to be the proliferation of viable myxomatous cells within the bone marrow. Osseous remodeling adjacent to the cysts was secondary to expansion of the soft tissue contents of the early cysts and later vascularization with fibrosis in the older cysts. Stress fracturing was a focal feature secondary to the remodeling of live bone. Advanced degenerative arthritis demonstrated focal osteocytic necrosis in the exposed osseous surface. Bone necrosis was also observed when small segments of the surface were undermined by cysts. Finally, bone necrosis was occasionally observed as focal infarcts of the joint surface (2-6 mm). In all three instances, bone necrosis in degenerative arthritis appeared to be a secondary reaction, presumably related to local disruption of blood supply. PMID:6825342

Milgram, J W

1983-03-01

273

Blind confirmation in Leiden of Geczy factor on the cells of Dutch patients with ankylosing spondylitis  

SciTech Connect

A follow-up blind study, of the ability of cross-reactive antisera to distinguish between the cells of Dutch patients with ankylosing spondylitis (AS) and normal controls, was performed in Leiden. Of the 45 cell samples tested, 29 were fresh peripheral blood mononuclear (PBM) cells while 15 were cryopreserved PBM. No false positives but one false negative was identified among the 45 samples, and the negative was confirmed after the recoded cryopreserved cells from this patient were retested. It is concluded that the cross-reactive antisera raised in Sydney give good discrimination between patients and normals. Factors affecting the success of the /sup 51/Cr-release cytotoxicity assay, and possible reasons for the failure of others to confirm these observations, are briefly discussed.

Geczy, A.F.; van Leeuwen, A.; van Rood, J.J.; Ivanyi, P.; Breur, B.S.; Cats, A.

1986-11-01

274

Triggering infections in reactive arthritis.  

PubMed Central

Certain microbes like yersinia, salmonella, shigella, campylobacter, chlamydia, and possibly gonococcus can trigger reactive arthritis especially in patients of the HLA-B27 type. In the present study we have used serological and culture methods to identify the probable triggering infection in 50 consecutive HLA-B27 positive patients diagnosed as having reactive arthritis. The two most common triggering agents thus identified were Yersinia enterocolitica (12 patients) and Chlamydia trachomatis (11 patients). In addition six patients had high antistreptolysin O titres and two high teichoic acid antibody titres suggesting group A streptococci and Staphylococcus aureus as triggering agents. In 13 patients no preceding infection could be identified. The identity of the infective agent seems to have very little effect on the clinical picture of the reactive arthritis - the only difference between the various aetiological groups in the present material was absence of fever in the patients with a preceding C. trachomatis infection, of whom only one out of 11 had a temperature greater than or equal to 38 degrees C, whereas 13 of 16 patients with a preceding enterobacterial, and five of the eight patients with a streptococcal or staphylococcal infection had raised temperatures. PMID:3874607

Valtonen, V V; Leirisalo, M; Pentikäinen, P J; Räsänen, T; Seppälä, I; Larinkari, U; Ranki, M; Koskimies, S; Malkamäki, M; Mäkelä, P H

1985-01-01

275

Factor V Leiden mutation is not a predisposing factor for acute coronary syndromes  

PubMed Central

Background The prevalence of Coronary artery disease (CAD) in India has increased considerably over the past few years and could become the number one killer disease if interventions are not done. Factor V Leiden (FVL) mutation and FII G20210A polymorphism are two recently described genetic factors with a propensity towards venous thrombosis. This warrants the investigations for thrombophilia in myocardial infarction patients in India. Methods The study cohort consisted of 51 patients aged below 50 years presenting with acute coronary syndromes. In both patient group and normal individuals the major risk factors Protein C deficiency, Protein S deficiency, anticardiolipin antibodies, Fibrinogen and Lipoprotein [a] were studied. Factor V Leiden (FVL) G1691A mutation in both control and patient group was looked by using Polymerase chain reaction (PCR) followed by sequencing of the PCR products. Results Our results indicated significantly higher levels of anticardiolipin antibodies and fibrinogen in the patients and absence of FVL (G1691A) mutation in our study cohort. One of the patients (H5) showed insertion of an extra A nucleotide in exon 10 of the Factor V gene resulting in frame shift mutation in this patient. Conclusion The results of present study showed absence of FVL mutation in our population. However, there is a need to confirm the above findings on patients from different populations from different parts of the country. The insertion of an extra A in exon 10 in the patient needs to be ascertained to confirm that it is one of its kinds or is prevalent in the population. PMID:23253409

Himabindu, G.; Rajasekhar, D.; Latheef, K.; Sarma, P.V.G.K.; Vanajakshamma, V.; Chaudhury, Abhijit; Bitla, Aparna R.

2012-01-01

276

Effect of Low Dose Atorvastatin Versus Diet-Induced Cholesterol Lowering on Atherosclerotic Lesion Progression and Inflammation in Apolipoprotein E*3Leiden Transgenic Mice  

Microsoft Academic Search

Objective—To evaluate whether low-dose atorvastatin suppresses atherosclerotic lesion progression and inflammation in apolipoprotein E*3 (apoE*3)-Leiden mice beyond its cholesterol-lowering effect. Methods and Results—ApoE*3-Leiden mice were fed a high-cholesterol (HC) diet until mild atherosclerotic lesions had formed. Subsequently, HC diet feeding was continued or mice received HC supplemented with 0.002% (w\\/w) atorvastatin (HCA), resulting in 19% plasma cholesterol lowering, or mice

Lars Verschuren; Robert Kleemann; Erik H. Offerman; Alexander J. Szalai; Sjef J. Emeis; Hans M. G. Princen; Teake Kooistra

2010-01-01

277

Is juvenile rheumatoid arthritis\\/juvenile idiopathic arthritis different from rheumatoid arthritis?  

Microsoft Academic Search

CHAPTER SUMMARY: The chronic arthropathies of childhood share clinical and pathological features with rheumatoid arthritis (RA) in adults. Both are autoimmune diseases characterized by a destructive arthropathy. Both are likely to be complex genetic traits, with autoantibodies and with a type-1-T-helper-cell cytokine profile in disease tissues. In common with other autoimmune diseases, both have associations and linkage with human keukocyte

Sampath Prahalad; David N Glass

2002-01-01

278

Anti-atherosclerotic effect of amlodipine, alone and in combination with atorvastatin, in APOE*3-Leiden/hCRP transgenic mice.  

PubMed

We investigated the pleiotropic effects of a calcium antagonist (amlodipine) on early atherosclerosis development in the presence and absence of an HMG-CoA-reductase inhibitor (atorvastatin) in apolipoprotein E*3-Leiden/human C-reactive protein (E3L/CRP) transgenic mice. Male E3L/CRP transgenic mice were fed a cholesterol-containing diet either with or without amlodipine and/or atorvastatin. After 31 weeks, atherosclerosis in the aortic root area was quantified. Treatment with amlodipine did not significantly lower blood pressure, but resulted in a 43% reduction (P < 0.03) of lesion area as compared with the untreated group. Treatment with atorvastatin resulted in an 80% reduction of lesion area as compared with the untreated group (P < 0.001). Combined treatment with amlodipine and atorvastatin decreased the lesion area by 93%, significantly more than either treatment alone (P < 0.008). Plasma C-reactive protein levels were mildly elevated, on average 10 +/- 6 mg/L, and did not differ between groups, neither on baseline nor during treatment. Treatment with amlodipine, independently of blood pressure lowering, reduced atherosclerosis development in E3L/CRP mice. Atorvastatin had a strong anti-atherosclerotic effect, whereas co-treatment with amlodipine enhanced this effect significantly. Plasma C-reactive protein levels were not affected by any of the three treatments. PMID:16424791

Trion, Astrid; de Maat, Moniek; Jukema, Wouter; Maas, Annemarie; Offerman, Erik; Havekes, Louis; Szalai, Alex; van der Laarse, Arnoud; Princen, Hans; Emeis, Jef

2006-01-01

279

Septic arthritis of the temporomandibular joint successfully treated with arthroscopic lysis and lavage: case report and review of the literature.  

PubMed

Septic arthritis of the temporomandibular joint (TMJ) is infrequently reported. We present a case of septic arthritis of the TMJ following the extraction of the left upper second molar that occurred 1 week before beginning of symptoms. No evident predisposing factors were detected. Arthroscopic diagnosis of septic arthritis, lysis and lavage, and capsular stretch were performed. Cultures taken from the TMJ space grew Streptococcus sp. After 1 month of antimicrobial therapy the patient was asymptomatic and mandibular function was normal. Literature related to septic arthritis of TMJ and its treatment was reviewed. Different surgical procedures are available to treat this condition. Arthroscopy should be preferred as initial treatment on account of the possibility of drainage and accurate lavage under direct visualization of joint space, at the same time allowing confirmation of diagnostic hypotheses. Improving joint mobility with lysis of adhesions and capsular stretch in an early stage of disease may be helpful in stopping the fibrosis process. PMID:17095265

Sembronio, Salvatore; Albiero, Alberto Maria; Robiony, Massimo; Costa, Fabio; Toro, Corrado; Politi, Massimo

2007-02-01

280

Microalbuminuria in patients with rheumatoid arthritis  

Microsoft Academic Search

OBJECTIVES--To assess (a) the prevalence of microalbuminuria in patients with rheumatoid arthritis, (b) the association between urinary albumin excretion and disease activity as estimated by the erythrocyte sedimentation rate and C reactive protein (CRP), and (c) the association between urinary albumin excretion and treatment with antirheumatic drugs. METHODS--Sixty five patients with rheumatoid arthritis attending two rheumatology clinics were compared with

L M Pedersen; H Nordin; B Svensson; H Bliddal

1995-01-01

281

The nail dystrophy of psoriatic arthritis  

Microsoft Academic Search

Nail abnormalities occur frequently in patients with psoriatic arthritis. This study of the finger nails of 46 patients with psoriatic arthritis, 100 nonpsoriatic rheumatism patients, and 100 nonpsoriatic general medical patients was designed to characterise these abnormalities with particular reference to the severity of nail pitting. The results of the study suggest: (1) Onycholysis alone in the absence of previous

C J Eastmond; V Wright

1979-01-01

282

Group education for patients with rheumatoid arthritis  

Microsoft Academic Search

Patients with rheumatoid arthritis must learn to adjust their exercise, rest and medication to the varying activity of the disease. Patient education can help patients in making the right decisions about adjustments in their treatment regimen and in attaining ¿self-management¿ behaviors. We developed a group education program based on social learning theory and the `Arthritis Self Management Course¿ developed in

Erik Taal; Rob P. Riemsma; Herman L. M. Brus; Erwin R. Seydel; Johannes J. Rasker; Oene Wiegman

1993-01-01

283

Recovery of clinical but not radiographic outcomes by the delayed addition of adalimumab to methotrexate-treated Japanese patients with early rheumatoid arthritis: 52-week results of the HOPEFUL-1 trial  

PubMed Central

Objective. The aim of this study was to compare efficacy outcomes of initial treatment with adalimumab + MTX vs adalimumab addition following 26 weeks of MTX monotherapy in Japanese early RA patients naive to MTX with high disease activity. Methods. Patients completing the 26-week, randomized, placebo-controlled trial of adalimumab + MTX were eligible to receive 26 weeks of open-label adalimumab + MTX. Patients were assessed for mean change from baseline in the 28-joint DAS with ESR (DAS28-ESR) and modified total Sharp score (mTSS), and for the proportions of patients achieving clinical, functional or radiographic remission. Results. Of 333 patients assessed, 278 (137 from the initial adalimumab + MTX and 141 from the initial placebo + MTX groups) completed the 52-week study. Significant differences in clinical and functional parameters observed during the 26-week blinded period were not apparent following the addition of open-label adalimumab to MTX. Open-label adalimumab + MTX slowed radiographic progression through week 52 in both groups, but patients who received adalimumab + MTX throughout the study exhibited less radiographic progression than those who received placebo + MTX during the first 26 weeks (mean ?mTSS at week 52 = 2.56 vs 3.30, P < 0.001). Conclusion. Delayed addition of adalimumab in Japanese MTX-naive early RA patients did not impact clinical and functional outcomes at week 52 compared with the earlier addition of adalimumab. However, the accrual of significant structural damage during blinded placebo + MTX therapy contributed to the persistence of differences between the treatment strategies, suggesting that Japanese patients at risk for aggressive disease should benefit from the early inclusion of adalimumab + MTX combination therapy. Trial registration. ClinicalTrials.gov (http://clinicaltrials.gov/), NCT00870467. PMID:24441150

Ishiguro, Naoki; Takeuchi, Tsutomu; Miyasaka, Nobuyuki; Mukai, Masaya; Matsubara, Tsukasa; Uchida, Shoji; Akama, Hideto; Kupper, Hartmut; Arora, Vipin; Tanaka, Yoshiya

2014-01-01

284

Livedoid vasculopathy associated with combined prothrombin G20210A and factor V (Leiden) heterozygosity and MTHFR C677T homozygosity.  

PubMed

Livedoid vasculopathy (LV) is an occlusive thrombotic disease of lower extremities. A 34-year-old woman presented with 4-year history of recurrent necrotic and painful lesions with violaceous and purpuric border on both legs. Initial treatment with hydroxychloroquine, dapsone and prednisone were unsuccessful. Skin biopsy showed inflammatory infiltrate with epidermal necrosis. Prothrombin G20210A and factor V-Leiden heterozygosity, and MTHFR C677T homozygosity with hyperhomocysteinemia were confirmed. LV diagnosis was made; acetylsalicylic acid, folic acid, vitamin B12, and prednisone treatement resulted in complete healing. This is the first report on coexistence of prothrombin G20210A, factor V-Leiden, and homozygous MTHFR C677T with hyperhomocysteinemia in LV. PMID:18360788

Irani-Hakime, Noha A; Stephan, Farid; Kreidy, Raghid; Jureidini, Isabelle; Almawi, Wassim Y

2008-08-01

285

Prospective risk of cancer and the influence of tobacco use in carriers of the p16-Leiden germline variant.  

PubMed

The p16-Leiden germline variant in the CDKN2A gene is associated with a high risk of melanoma and pancreatic cancer. The aims of this study were to assess the risk of developing other cancers and to determine whether tobacco use would alter cancer risk in carriers of such a variant. We therefore prospectively evaluated individuals with a p16-Leiden germline variant, participating in a pancreatic surveillance programme, for the occurrence of cancer (n=150). Tobacco use was assessed at the start of the surveillance programme. We found a significantly increased risk for melanoma (relative risk (RR) 41.3; 95% confidence interval (CI) 22.9-74.6) and pancreatic cancer (RR 80.8; 95% CI 44.7-146). In addition, increased risks were found for cancers of the lip, mouth and pharynx (RR 18.8; 95% CI 6.05-58.2) and respiratory tumours (RR 4.56; 95% CI 1.71-12.1). Current smokers developed significantly more cancers of the lip, mouth and pharynx, respiratory system and pancreas compared with former and never-smokers. In conclusion, this study shows that carriers of a p16-Leiden variant have an increased risk of developing various types of cancer, and smoking significantly increases the risk of frequently occurring cancers. Smoking cessation should be an integral part of the management of p16-Leiden variant carriers.European Journal of Human Genetics advance online publication, 17 September 2014; doi:10.1038/ejhg.2014.187. PMID:25227142

Potjer, Thomas P; Kranenburg, Heidi E; Bergman, Wilma; de Vos Tot Nederveen Cappel, Wouter H; van Monsjou, Hester S; Barge-Schaapveld, Daniela Q C M; Vasen, Hans F A

2014-09-17

286

Glucocorticoids in juvenile idiopathic arthritis.  

PubMed

Glucocorticoid (GC) drugs are a potent and rapidly effective therapeutic option for the treatment of juvenile idiopathic arthritis (JIA). These medications are mainly used for the management of the extra-articular features of systemic-onset disease. A course of low-dose prednisone may be considered for achieving a rapid disease control in patients with severe polyarthritis refractory to other therapies or while awaiting the full therapeutic effect of a recently initiated disease-modifying antirheumatic drug or biologic agent. Short-term systemic GC administration may also be indicated for chronic iridocyclitis unresponsive to topical therapy. The general objective of GC therapy is to limit the maximum dose and exposure to the highest doses to what is needed to achieve disease control, and then to gradually taper the dose until the minimum level sufficient to maintain disease quiescence over time is reached. High-dose intravenous 'pulse' methylprednisolone administration is sometimes chosen to treat the most severe or acute disease manifestations of systemic JIA, particularly macrophage activation syndrome. Intra-articular GC injection is a safe and rapidly effective treatment for synovitis in children with chronic arthritis. Triamcinolone hexacetonide is the optimal GC preparation for pediatric patients. Local injection therapy is used most frequently to treat oligoarthritis, but the strategy of performing multiple injections to induce disease remission, while simultaneously initiating therapy with second-line or biologic agents, has also been proposed for children with polyarticular JIA. Administration of GCs is associated with potentially deleterious adverse effects, some of which can be irreversible. This highlights the need of a judicious use of these medications and careful monitoring of their toxicity. The recently published recommendations for the management of JIA provide useful guidance to the clinicians for the administration of GCs in children with chronic arthritis. PMID:25227183

Schiappapietra, Benedetta; Varnier, Giulia; Rosina, Silvia; Consolaro, Alessandro; Martini, Alberto; Ravelli, Angelo

2015-01-01

287

Lower limb joint replacement in rheumatoid arthritis  

PubMed Central

Introduction There is limited literature regarding the peri-operative and surgical management of patients with rheumatoid disease undergoing lower limb arthroplasty. This review article summarises factors involved in the peri-operative management of major lower limb arthroplasty surgery for patients with rheumatoid arthritis. Methods We performed a search of the medical literature, using the PubMed search engine (http://www.pubmed.gov). We used the following terms: ‘rheumatoid’ ‘replacement’ ‘arthroplasty’ and ‘outcome’. Findings The patient should be optimised pre-operatively using a multidisciplinary approach. The continued use of methotrexate does not increase infection risk, and aids recovery. Biologic agents should be stopped pre-operatively due the increased infection rate. Patients should be made aware of the increased risk of infection and periprosthetic fracture rates associated with their disease. The surgical sequence is commonly hip, knee and then ankle. Cemented total hip replacement (THR) and total knee replacement (TKR) have superior survival rates over uncemented components. The evidence is not clear regarding a cruciate sacrificing versus retaining in TKR, but a cruciate sacrificing component limits the risk early instability and potential revision. Patella resurfacing as part of a TKR is associated with improved outcomes. The results of total ankle replacement remain inferior to THR and TKR. RA patients achieve equivalent pain relief, but their rehabilitation is slower and their functional outcome is not as good. However, the key to managing these complicated patients is to work as part of a multidisciplinary team to optimise their outcome. PMID:22697352

2012-01-01

288

Painful feet in rheumatoid arthritis.  

PubMed

Pain in the feet is an important diagnostic feature and a major management problem of rheumatoid arthritis. Of 50 hospitalized patients, 28% recalled painful feet as the sole presenting symptom of their disease.RHEUMATOID DISEASE COMMONLY AFFECTS THE FEET: 90% of the patients studied complained of foot pain at some time during the course of their disease, 86% had clinical involvement and 92% had radiological changes in their feet.The forefoot is most frequently involved. Midfoot involvement was noted in 68% but was symptomatic in only 22%. Changes in the ankle were least common but always symptomatic. PMID:4746132

Minaker, K; Little, H

1973-10-20

289

Metabolic Syndrome in Rheumatoid Arthritis  

PubMed Central

Insulin resistance is an essential feature of the metabolic syndrome that has been linked to rheumatoid arthritis (RA). Understanding how inflammation arising in one tissue affects the physiology and pathology of other organs remains an unanswered question with therapeutic implications for chronic conditions including obesity, diabetes mellitus, atherosclerosis, and RA. Adipokines may play a role in the development of atherogenesis in patients with RA. Biologic therapies, such as TNF-? antagonists, that block proinflammatory cytokines have beneficial effects on the insulin resistance that is often observed in patients with RA. PMID:23431244

Ferraz-Amaro, Iván; González-Juanatey, Carlos; López-Mejias, Raquel; Riancho-Zarrabeitia, Leyre; González-Gay, Miguel A.

2013-01-01

290

Endogenous IL-22 Plays a Dual Role in Arthritis: Regulation of Established Arthritis via IFN-? Responses  

PubMed Central

Objective IL-22 is elevated in patients with inflammatory arthritis and correlates with disease activity. IL-22 deficient mice have reduced incidence of arthritis. Recombinant IL-22 restrains progression of arthritis via increase in IL-10 responses when administered prior to onset of arthritis. These findings imply a possible dual role of IL-22 in inflammatory arthritis depending on the phase of arthritis. Experiments outlined here were designed to elucidate the contribution of endogenous IL-22 before and after the onset of arthritis. Methods Collagen induced arthritis (CIA) was induced in DBA1 or IFN-? deficient mice following immunization with collagen and complete Freund's adjuvant. Anti-IL-22 antibody or isotype control were administered prior to or after onset of arthritis and disease progression assessed by clinical scoring and histopathology. IL-22, IL-17 and IFN-? responses were measured by ELISA and flowcytometry. Anti-collagen antibody responses were analyzed by ELISA. Expression of IL-22R1 in CD4+ cells was elucidated by flowcytometry and real time PCR. Results Collagen specific IL-22 responses were expanded during arthritis and IL-22 producing cells were discrete from IL-17 or IFN-? producing cells. Neutralization of IL-22 after onset of arthritis resulted in significant increase in Th1 responses and significantly reduced severity of arthritis. CD4+ cells from arthritic mice showed increased surface expression of IL-22R1. In vitro, CD4+T cells cultured with antigen presenting cells in the presence or absence of IL-22 suppressed or induced IFN-?, respectively. The protective effect of anti-IL-22 was reversed in IFN-? deficient mice. Moreover, administration of anti-IL-22 prior to onset of arthritis augmented arthritis severity. Conclusion We show for the first time that IL-22 plays a dual role: protective prior to the onset of arthritis and pathogenic after onset of arthritis. The pathogenic effect of IL-22 is dependent on suppression of IFN-? responses. IL-17 responses remained unchanged with the administration of anti-IL22 antibody. IL-22R1 is upregulated on CD4+T cells during arthritis and regulates IFN-? in T cells. PMID:24676270

Justa, Shivali; Zhou, Xiaoqun; Sarkar, Sujata

2014-01-01

291

Leprosy and rheumatoid arthritis: consequence or association?  

PubMed Central

Leprosy or Hansen’s disease is a chronic granulomatous infectious disease caused by Mycobacterium leprae with a high prevalence in some developing countries however, it is rarely seen in non-endemic regions. Arthritis has been described in all types of Hansen’s disease. Chronic arthritis is known to exist even in paucibacillary forms, resolved or treated disease and in patients without reaction, suggesting a perpetuated inflammatory process. In these cases leprosy can mimic some autoimmune diseases such as rheumatoid arthritis. When a patient with a history of leprosy presents with a symmetric, distal, polyarthritis the diagnosis may not be linear. Possibly it is a rheumatoid-like leprous arthritis with M leprae acting as the trigger element for the chronic process or it is an overlap condition, with a concomitant rheumatoid arthritis? A case report of a patient with a chronic inflammatory arthritis with 10 years of evolution is presented. The differential diagnosis between leprous and rheumatoid arthritis is discussed. PMID:22891014

Henriques, Celia Coelho; Lopéz, Begoña; Mestre, Tiago; Grima, Bruno; Panarra, António; Riso, Nuno

2012-01-01

292

Rheumatoid Arthritis and Cardiovascular Disease  

PubMed Central

Background Rheumatic disease and heart disease share common underpinnings involving inflammation. The high levels of inflammation that characterize rheumatic diseases provide a “natural experiment” to help elucidate the mechanisms by which inflammation accelerates heart disease. Rheumatoid arthritis (RA) is the most common of the rheumatic diseases and has the best studied relationships with heart disease. Methods Review of current literature on heart disease and rheumatoid arthritis Results Patients with RA have an increased risk of developing heart disease that is not fully explained by traditional cardiovascular risk factors. Therapies used to treat RA may also affect the development of heart disease; by suppressing inflammation, they may also reduce the risk of heart disease. However, their other effects, as in the case of steroids, may increase heart disease risk. Conclusions Investigations of the innate and adaptive immune responses occurring in RA may delineate novel mechanisms in the pathogenesis of heart disease, and help identify novel therapeutic targets for the prevention and treatment of heart disease. PMID:24093840

Crowson, Cynthia S; Liao, Katherine P; Davis, John M; Solomon, Daniel H; Matteson, Eric L; Knutson, Keith L; Hlatky, Mark A; Gabriel, Sherine E

2014-01-01

293

The Drug Information Center Arthritis Project: Providing Patients with Interactive and Reliable Arthritis Internet Education  

Microsoft Academic Search

The objective of the Drug Information Center Arthritis Project was to create and assess the value of a patient-focused interactive arthritis education program. A multidisciplinary team developed three content areas: an interactive ask-a-pharmacist component with a satisfaction survey; health assessment tools (SF-8™, osteoarthritis [OA] Impact Survey™, and rheumatoid arthritis [RA] Impact Survey™); and disease and drug information. Results: There were

Nicole T. Ansani; Bethany A. Fedutes-Henderson; Robert J. Weber; Randall Smith; Jennine Dean; Molly Vogt; Kenneth Gold; C. Kent Kwoh; Thaddeus Osial; Terence W. Starz

2006-01-01

294

The disease formerly known as rheumatoid arthritis  

PubMed Central

Rheumatoid arthritis is a complex disease where predetermined and stochastic factors conspire to confer disease susceptibility. In light of the diverse responses to targeted therapies, rheumatoid arthritis might represent a final common clinical phenotype that reflects many pathogenic pathways. Therefore, it might be appropriate to begin thinking about rheumatoid arthritis as a syndrome rather than a disease. Use of genetics, epigenetics, microbiomics, and other unbiased technologies will probably permit stratification of patients based on mechanisms of disease rather than by clinical phenotype. PMID:25167330

2014-01-01

295

[Shoulder arthritis due to Haemophilus aphrophilus].  

PubMed

We report a case of shoulder arthritis due to Haemophilus aphrophilus. The patient, a 56 year-old woman, was immunocompetent. She presented with a septic arthritis of the left shoulder without portal of entry. A synovial fluid sample was cultured and positive for a gram-negative bacillus after 8 days. It was identified as Haemophilus aphrophilus, in the HACCEK group, by PCR ARN 16S. We did not find any associated endocarditis. The patient recovered. As far as we know, this is only the 5th reported case of arthritis due to this microorganism. PMID:15982845

Bouldouyre, M-A; Stawiarski, N; Michon, M; Nguyen Van, J-C; Ben-Ali, A; Rajzbaum, G; Goldstein, F-W

2005-06-01

296

Familial Mediterranean fever mimicking septic arthritis.  

PubMed

We report the case of a young Lebanese female who presented with recurrent episodes of left knee and calf swelling and a synovial fluid leucocyte count suggestive of septic arthritis, however bacteriologic cultures were negative. Familial Mediterranean fever (FMF) was suspected in view of a positive family history and genetic analysis for the mutations in the pyrin/marenostrin (MEFV) gene revealing a homozygote mutation at methionine-694-valine. The arthritis was controlled with prophylactic colchicine therapy. FMF should be considered in the differential diagnosis of acute monoarticular arthritis with elevated synovial fluid white blood cells counts in regions with high incidence of FMF. PMID:15700115

Uthman, Imad; El-Sayyad, Jinane; El-hajj, Ihab; Bizri, Abdul-Rahman

2005-10-01

297

Psoriatic arthritis in South and Central America.  

PubMed

Psoriasis and its related manifestations, including psoriatic arthritis, are prevalent disorders in the Western world, particularly among Caucasians. The study of these disorders in Latin America lags way behind the study of other more common rheumatic disorders, such as rheumatoid arthritis and systemic lupus erythematosus. From the scarce evidence available, however, it appears that the prevalence and incidence of psoriasis and psoriatic arthritis are lower than in other parts of the Western world and almost negligible among natives from the Andean region, although confirmatory epidemiologic studies are lacking. PMID:21552999

Toloza, Sergio M A; Valle-Oñate, Rafael; Espinoza, Luis R

2011-08-01

298

Photoacoustic tomography to identify angiogenesis for diagnosis and treatment monitoring of inflammatory arthritis  

NASA Astrophysics Data System (ADS)

Identifying neovascularity, i.e. angiogenesis, as a feature of inflammatory arthritis, can help in early diagnosis and treatment monitoring of this disease. Photoacoustic tomography (PAT), as a hybrid imaging modality, relies on intrinsic differences in the optical absorption among the tissues being imaged. Since blood has highly absorbing chromophores including both oxygenated and deoxygenated hemoglobin, PAT holds potential in identifying early angiogenesis associated with inflammatory joint diseases. In this study, we used PAT to identify the changes in the development of inflammatory arthritis, through the study on a well-established adjuvant-induced arthritis (AIA) rat model. Imaging at two different wavelengths, 1064 nm and 532 nm, revealed that there was a significant signal enhancement in the ankle joints of the arthritis affected rats when compared to the normal control group. Histological analysis of both the normal and the arthritic rats correlated well with the imaging findings. The results from this study suggest that the emerging PAT technology could become a new tool for clinical management of inflammatory joint diseases.

Wang, Xueding; Rajian, Justin; Girish, Gandikota; Chamberland, David

2013-03-01

299

Hepatocyte-specific IKK? expression aggravates atherosclerosis development in APOE*3-Leiden mice  

PubMed Central

Objective The liver is the key organ involved in systemic inflammation, but the relation between hepatic inflammation and atherogenesis is poorly understood. Since nuclear factor-?B (NF-?B) is a central regulator of inflammatory processes, we hypothesized that chronically enhanced hepatic NF-?B activation, through hepatocyte-specific expression of I?B kinase-? (IKK?) (LIKK), will aggravate atherosclerosis development in APOE*3-Leiden (E3L) mice. Methods and Results E3L.LIKK and E3L control littermates were fed a Western-type diet for 24 weeks. E3L.LIKK mice showed a 2.3-fold increased atherosclerotic lesion area and more advanced atherosclerosis in the aortic root with less segments without atherosclerotic lesions (11 vs. 42%), and more segments with mild (63% vs. 44%) and severe (26% vs. 14 %) lesions. Expression of LIKK did not affect basal levels of inflammatory parameters, but plasma cytokine levels tended to be higher in E3L.LIKK mice after lipopolysaccharide (LPS) administration. E3L.LIKK mice showed transiently increased plasma cholesterol levels, confined to (V)LDL. This transient character resulted in a mild (+17%) increased cumulative plasma cholesterol exposure. Conclusion We conclude that selective activation of NF-?B in hepatocytes considerably promotes atherosclerosis development which is (at least partly) explained by an increased sensitivity to proinflammatory triggers and transiently increased plasma cholesterol levels. PMID:21798539

Wong, Man C.; van Diepen, Janna A.; Hu, Lihui; Guigas, Bruno; de Boer, Hetty C.; van Puijvelde, Gijs H.; Kuiper, Johan; van Zonneveld, Anton J.; Shoelson, Steven E.; Voshol, Peter J.; Romijn, Johannes A.; Havekes, Louis M.; Tamsma, Jouke T.; Rensen, Patrick C.N.; Hiemstra, Pieter S.; Berbée, Jimmy F.P.

2014-01-01

300

Factor V Leiden does not have a role in cryptogenic ischemic stroke among Iranian young adults  

PubMed Central

Background: Different risk factors have been suggested for ischemic stroke in young adults. In a group of these patients despite of extensive diagnostic work-up, the primary cause remains unknown. Coagulation tendency is accounted as a possible cause in these patients. Previous studies on factor V Leiden (FVL) as the main cause of inherited thrombophilia for clarifying the role of FVL in stroke have resulted in controversial findings. The current study investigates the role of this factor in ischemic stroke among Iranians. Materials and Methods: This case-control study was performed between September 2007 and December 2008 in Isfahan, Iran. The case group comprised of 22 patients of which 15 were males and 7 were females with age range of ?50 years, diagnosed as ischemic stroke without classic risk factors and the control group consisted of 54 healthy young adults. After filling consent form, venous blood samples were obtained and sent to the laboratory for genetic examination. Results: No FVL mutation was found in the case group. There was one carrier of the mutation as heterozygous in the control group (relative frequency = 1.85%). Conclusions: Based on our study, FVL might not be considered as an independent risk factor for ischemic stroke in Iranian individuals who are not suffering from other risk factors of ischemic stroke. PMID:24761388

Kheradmand, Ehsan; Pourhossein, Meraj; Amini, Gilda; Saadatnia, Mohammad

2014-01-01

301

Factor V-Leiden Mutation: A Common Risk Factor for Venous Thrombosis among Lebanese Patients  

PubMed Central

Aim. Lebanon exhibits one of the highest prevalences of factor V-Leiden (FVL) in the world (14.4%). The aim of this study is to evaluate the incidence of FVL mutation among Lebanese patients with lower extremity venous thrombosis. Material and Methods. From January 2003 to January 2011, 283 consecutive Lebanese patients, diagnosed with deep venous thrombosis (DVT) by duplex scan, were retrospectively reviewed. FVL mutation was tested among patients with conditions highly suggestive of hypercoagulation states (65 patients). Results. FVL mutation was detected among 56.9% of patients, 68.6% of patients younger than 50 years, and 43.4% of patients older than 50 years (P = 0.041). FVL mutation was commonly reported in young adults, in patients with pregnancy, estrogen drugs, recurrent DVT, and resistance to anticoagulation. Conclusion. The high rate of FVL mutation observed among Lebanese patients with venous thrombosis is related to the high prevalence of this mutation in the Lebanese population. Thrombophilia screening should be tailored to accommodate a population's risk factor. In countries with high prevalence of FVL, this mutation should be screened among patients younger than 50 years and patients with situations highly suggestive of hypercoagulation states. PMID:22737581

Kreidy, Raghid

2012-01-01

302

Factor V Leiden and Thrombosis in Patients with Systemic Lupus Erythematosus (SLE): A Meta-analysis  

PubMed Central

To perform a meta-analysis of the association between the factor V Leiden polymorphism (FVL) and thrombosis among patients with SLE and/or antiphospholipid antibody (aPL) positivity. Included studies recruited patients based on SLE or aPL positive status, confirmed subjects' SLE diagnosis as defined by the American College of Rheumatology, and documented thrombotic events. Excluded studies were non-English or considered only arterial thrombosis. Individual patient data, available from five studies, together with unpublished data from 1210 European-American SLE patients from the UCSF Lupus Genetics Collection genotyped for FVL, were further analyzed. Seventeen studies (n=2090 subjects) were included in the initial meta-analysis. Unadjusted odds ratios (OR) were calculated to assess association of FVL with thrombosis. The OR for association of thrombosis with FVL was 2.88 (95% C.I. 1.98-4.20). In the secondary analysis with our individual patient dataset (n=1447 European-derived individuals), SLE subjects with the FVL polymorphism still had more than two times the odds of thrombosis compared to subjects without this polymorphism, even when adjusting for covariates such as gender, age, and aPL status. SLE and/or aPL positive patients with the FVL variant have more than two times the odds of thrombosis compared to those without this polymorphism. PMID:19421222

Kaiser, R.; Barton, J.L.; Chang, M.; Catanese, JJ.; Li, Y.; Begovich, A.B.; Criswell, LA.

2009-01-01

303

Independent associations of total and high molecular weight adiponectin with cardiometabolic risk and surrogate markers of enhanced early atherogenesis in black and white patients with rheumatoid arthritis: a cross-sectional study  

PubMed Central

Introduction Whether adiponectin levels associate with atherogenesis in RA is uncertain. We examined the independent relationships of total and high molecular weight (HMW) adiponectin concentrations with cardiometabolic risk and surrogate markers of enhanced early atherogenesis in black and white patients with RA. Methods We determined total and HMW adiponectin concentrations and those of endothelial activation molecules including soluble E-selectin, vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1), in 210 (119 black and 91 white) RA patients. Associations were determined in potential confounder and mediator adjusted mixed regression models. Results Total and HMW adiponectin concentrations related similarly to metabolic risk factors and endothelial activation. In all patients, total and HMW adiponectin concentrations associated paradoxically with high systolic, diastolic and mean blood pressure (partial R = 0.155 to 0.241, P ?0.03). Ethnic origin did not impact on these relationships (interaction P ?0.09). Total and HMW adiponectin concentrations associated with those of glucose in white and black patients respectively (partial R = -0.304, P = 0.006 and -0.246, P = 0.01). In black but not white participants, total and HMW adiponectin concentrations also related favorably to lipid profiles (partial R = 0.292 to 0.360, P ?0.003 for HDL cholesterol concentrations, -0.269 to -0.299, P ?0.006 for triglyceride concentrations and -0.302 to -0.390, P ?0.002 for total-HDL cholesterol ratio) and the number of metabolic risk factors (partial R = -0.210 to -0.238, P ?0.03). In white but not black patients, total and HMW adiponectin concentrations associated paradoxically with overall endothelial activation as estimated by a standard z-score of endothelial activation molecule concentrations (partial R = 0.262, P = 0.01 and 0.252, P = 0.02); in the respective models, the extent of effect of total and HMW adiponectin concentrations on endothelial activation was larger in white compared to black participants (standardized ? (SE) = 0.260 (0.107) versus -0.106 (0.107), P = 0.01 and 0.260 (0.120) versus -0.100 (0.111), P = 0.02). The HMW-total adiponectin ratio related inconsistently to metabolic risk factors and not to endothelial activation. Conclusion In this study, total and HMW adiponectin concentrations associated with increased blood pressure parameters, and in white patients additionally with endothelial activation. The potential mechanism(s) underlying these paradoxical relationships between adiponectin concentrations and cardiovascular risk in RA merit further investigation. PMID:24286214

2013-01-01

304

Rheumatoid Arthritis and Complementary and Alternative Medicine  

MedlinePLUS

... et al. Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: a review. Evidence-Based Complementary and Alternative Medicine: e-CAM . 2005;2(3):301–308. Cameron ...

305

Etoricoxib for arthritis and pain management  

PubMed Central

Nonsteroidal antiinflammatory drugs (NSAIDs), including selective cyclooxygenase (COX)-2 inhibitors, have come to play an important role in the pharmacologic management of arthritis and pain. Clinical trials have established the efficacy of etoricoxib in osteoarthritis, rheumatoid arthritis, acute gouty arthritis, ankylosing spondylitis, low back pain, acute postoperative pain, and primary dysmenorrhea. Comparative studies indicate at least similar efficacy with etoricoxib versus traditional NSAIDs. Etoricoxib was generally well tolerated in these studies with no new safety findings during long-term administration. The gastrointestinal, renovascular, and cardiovascular tolerability profiles of etoricoxib have been evaluated in large patient datasets, and further insight into the cardiovascular tolerability of etoricoxib and diclofenac will be gained from a large ongoing cardiovascular outcomes program (MEDAL). The available data suggest that etoricoxib is an efficacious alternative in the management of arthritis and pain, with the potential advantages of convenient once-daily administration and superior gastrointestinal tolerability compared with traditional NSAIDs. PMID:18360581

Brooks, Peter; Kubler, Paul

2006-01-01

306

ASTROMEDICINE IN THE TREATMENT OF RHEUMATOID ARTHRITIS  

PubMed Central

One patient of rheumatoid arthritis was treated according to astromedicine. Wearing of Coral beads had remarkable effect on the disease. The interesting finding are reported in this paper. PMID:22556538

Janai, Sudhakar; Biviji, A. T.; Naik, D. G.; Lakhe, R. T.; Rao, V. Bhaskar

1991-01-01

307

Psoriasis/Psoriatic Arthritis and Pregnancy  

MedlinePLUS Videos and Cool Tools

... have psoriasis/psoriatic arthritis? Are you pregnant or breastfeeding? Dr. Eichenfield, a pediatric and adolescent dermatologist with ... FACT SHEET . Now you can get pregnancy and breastfeeding health tips from OTIS throughout the day! Join ...

308

Accommodation and Compliance Series: Employees with Arthritis  

MedlinePLUS

... him with a cart. A vice president with osteoarthritis had difficulty maintaining her stamina during the workday. ... rheumatoid arthritis was limited in typing due to pain and stiffness in her hands due to cold ...

309

Psoriatic inflammation facilitates the onset of arthritis in a mouse model.  

PubMed

Psoriatic arthritis (PsA) is a seronegative, inflammatory joint disease associated with psoriasis. In most patients with PsA, skin lesions precede arthritis; however, the causality of skin inflammation for the development of arthritis remains unclear. Gp130(F759/F759) knock-in (F759) mice develop autoimmune arthritis after 1 year of age through persistent signal transducer and activator of transcription 3 (Stat3) activation due to impairment in SOCS3-dependent negative regulation. Here, we crossed F759 mice with K5.Stat3C transgenic mice, in which keratinocytes express constitutive active Stat3 (Stat3C), leading to generation of psoriasis-like skin change. F759 mice harboring the K5.Stat3C transgene not only had aggravated skin lesions but also spontaneously developed arthritis with high penetrance in adjacent paws as early as 3 weeks of age. The joint lesions included swelling of the peripheral paws and nail deformities contiguous with the skin lesions, closely resembling PsA. Histopathologic study revealed enthesitis and bone erosions, with mononuclear cell infiltrates. Quantitative reverse transcriptase-PCR (RT-PCR), immunohistochemical analyses, and flow cytometry showed upregulation of the IL-23/T helper type 17 (Th17) pathway in affected joints. Furthermore, enforced generation of psoriasis-like skin inflammation by topical treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) in F759 mice induced swelling of the underlying joints. This animal model renders psoriatic inflammation as the driver of arthritis and helps to further understand the pathogenesis of PsA. PMID:25268586

Yamamoto, Mayuko; Nakajima, Kimiko; Takaishi, Mikiro; Kitaba, Shun; Magata, Yasuhiro; Kataoka, Sayo; Sano, Shigetoshi

2015-02-01

310

Sexual dysfunction among patients with arthritis  

Microsoft Academic Search

Summary  The relationship of arthritis and sexual dysfunction was investigated among 169 patients with rheumatoid arthritis, osteoarthritis and spondyloarthropathy, 130 of whom were pair-matched to controls. Assessments of marital happiness and depressed mood were also made using the CES-D and the Azrin Marital Happiness Scale (AMHS). Sexual dysfunctions were found to be common among patients and controls, the majority in both

D. J. Blake; R. Maisiak; A. Koplan; G. S. Alarcón; S. Brown

1988-01-01

311

Clinical management of septic arthritis in cattle.  

PubMed

Synovial fluid, ultrasound, and radiographic imaging are common diagnostic tools for septic arthritis. Mycoplasma septic arthritis is suspected in calves with clinical signs of otitis and pneumonia. Commonly affected joints are carpus, stifle, and tarsus. Treatment strategy must include long-term antibiotics, anti-inflammatories, and joint lavage. Knowledge of communication and boundaries for commonly affected joints is essential to perform joint lavage and arthrotomy. PMID:24534665

Desrochers, André; Francoz, David

2014-03-01

312

T cells in rheumatoid arthritis  

PubMed Central

Over the past decade and a half, advances in our understanding of the pathogenesis of immune-mediated diseases such as rheumatoid arthritis (RA) have translated directly into benefit for patients. Much of this benefit has arisen through the introduction of targeted biological therapies. At the same time, technological advances have made it possible to define, at the cellular and molecular levels, the key pathways that influence the initiation and persistence of chronic inflammatory autoimmune reactions. As our understanding grows, it is likely that this knowledge will be translated into a second generation of biological therapies that are tailor-made for the patient. This review summarizes current perspectives on RA disease pathogenesis, with particular emphasis on what RA T cells look like, what they are likely to see, and how they contribute to persistence of the chronic inflammatory response. PMID:19007421

Cope, Andrew P

2008-01-01

313

Rheumatoid arthritis: coping with disability.  

PubMed

This article explains the components of disability as related to rheumatoid arthritis (RA) using an expansion of Nagi's Model of Disability (Jette, 2006) and the World Health Organization's (WHO) International Classification of Functioning, Disability, and Health (ICF). In addition, suggestions for ways in which nurses can offer patients choices in physical functional therapy and psychosocial aspects of coping with the chronicity of RA are discussed. Understanding how RA relates to the holistic management of the patient will allow nurses to modify and suggest additional measures to enhance the outcomes of patient-centered care. Many degrees of disability exist that affect the physical and psychosocial domains of RA. Nurses should identify the primary issues influencing disability and assemble supporting resources or a multidisciplinary team to manage a person's disabilities. As nurses develop and maintain relationships with patients, they are able to follow through with the care plan continuum and recognize when modifications are needed. PMID:20306616

Barker, Tara L; Puckett, Theresa L

2010-01-01

314

Painful feet in rheumatoid arthritis  

PubMed Central

Pain in the feet is an important diagnostic feature and a major management problem of rheumatoid arthritis. Of 50 hospitalized patients, 28% recalled painful feet as the sole presenting symptom of their disease. Rheumatoid disease commonly affects the feet: 90% of the patients studied complained of foot pain at some time during the course of their disease, 86% had clinical involvement and 92% had radiological changes in their feet. The forefoot is most frequently involved. Midfoot involvement was noted in 68% but was symptomatic in only 22%. Changes in the ankle were least common but always symptomatic. ImagesFIG. 1AFIG. 1BFIG. 2AFIG. 2BFIG. 3FIG. 4FIG. 5 PMID:4746132

Minaker, K.; Little, H.

1973-01-01

315

Sialochemistry in juvenile chronic arthritis.  

PubMed

Stimulated parotid gland secretions collected from 16 patients with juvenile chronic arthritis (JCA) were analysed and the results compared with those obtained from 83 healthy sex-, age-, and socioeconomic status-matched children. Parotid salivary flow rate was measured and the saliva samples were assayed for calcium, phosphorus, potassium, chloride, sodium, urea, lysozyme, amylase and immunoglobulin levels (IgA, Ig, IgM). Our results showed that parotid flow rate (PFR) values in JCA patients were not statistically different from those in healthy controls. However, the mean salivary concentrations of calcium, phosphorus, potassium, lysozyme and IgA were significantly lower in the patients. These data could provide an explanation for the increased incidence of caries and gingivitis observed in JCA. PMID:2477107

Siamopoulou, A; Mavridis, A K; Vasakos, S; Benecos, P; Tzioufas, A G; Andonopoulos, A P

1989-10-01

316

Arthritis  

MedlinePLUS Videos and Cool Tools

... include the ones: • between the palm of the hands and the fingers • between the vertebrae • in the ... For example, an unresponsive wrist can cause the hand to be almost useless. If an unresponsive wrist ...

317

Judging disease activity in clinical practice in rheumatoid arthritis: first step in the development of a disease activity score  

Microsoft Academic Search

An investigation of clinical and laboratory variables which might form the basis for judging disease activity in clinical practice was made by six rheumatologists in a prospective study of up to three years' duration of 113 patients with early rheumatoid arthritis. Decisions to start treatment with slow acting antirheumatic drugs were equated with moments of high disease activity. If treatment

D M van der Heijde; M A van't Hof; P L van Riel; L A Theunisse; E W Lubberts; M A van Leeuwen; M H van Rijswijk; L B van de Putte

1990-01-01

318

Arthritis and pain. Psychosocial aspects in the management of arthritis pain  

Microsoft Academic Search

The purpose of this review is to summarize psychosocial factors associated with arthritis pain and highlight recent evidence for psychosocial approaches to managing arthritis pain. By definition, psychosocial factors refer to two dimensions of experience: the psychological (cognitive, affective) and social (interacting with others, engaging in life activities). Psychosocial factors influence the perception of pain and the presence of pain

Catherine L Backman

2006-01-01

319

Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis  

PubMed Central

Background Modulation of Jak?STAT signalling may provide an effective therapeutic strategy in inflammatory arthritis. Objective To document Jak?STAT expression in a cohort of patients with active rheumatoid arthritis (RA), spondyloarthritis (SpA), and osteoarthritis (OA) and compare these subsets with normal synovial tissue. Methods Synovial tissue biopsy specimens from patients with RA, OA, and SpA and histologically normal tissue (n?=?10 in each arthritis group) were examined for the presence of Jak3, STAT1, STAT4, and STAT6 expression using immunohistochemistry. Phenotyping was performed using immunohistochemistry and immunofluorescence. Clinical and serological characteristics of patients with RA expressing Jak3?STAT4 were assessed. Results STAT1, STAT4, and Jak3 protein expression was generally increased in inflammatory arthritis. In contrast, STAT6 expression was relatively heterogeneous. A subpopulation of CD1a positive dendritic cells unique to seropositive patients with RA was detected. These cells showed intense protein expression for Jak3, STAT4, and STAT6. Conclusion CD1a positive dendritic cells intensely express Jak3, STAT4, and STAT6 in seropositive RA tissue and may be an alternative marker for dendritic cells in their early stages of activation as well as providing a tool for identifying RA at the level of the synovium. Jak3 inhibition may be a potential therapeutic target to prevent dendritic cell maturation in RA. STAT1 expression is increased in inflammatory arthritis, suggesting that its pro?apoptotic and anti?inflammatory effects cannot effectively counteract inflammation. STAT6 expression is heterogeneous in synovium, suggesting a possible homoeostatic role in addition to any anti?inflammatory effects. PMID:16096332

Walker, J G; Ahern, M J; Coleman, M; Weedon, H; Papangelis, V; Beroukas, D; Roberts?Thomson, P J; Smith, M D

2006-01-01

320

Circadian use of glucocorticoids in rheumatoid arthritis.  

PubMed

A clear temporal relationship exists in rheumatoid arthritis (RA) patients between increased nocturnal levels of pro-in?ammatory cytokines, such as TNF-? and interleukin (IL)-6, pro-inflammatory hormones (i.e. melatonin, prolactin) and insufficient night production of the anti-in?ammatory cortisol (circadian rhythm). Under long-standing chronic stress of disease, insufficient cortisol is available to inhibit an ongoing nocturnal immune/inflammatory reaction. Clinical RA symptoms follow the same circadian rhythm with highest morning severity. Chronotherapy with nighttime glucocorticoid (GC) availability optimizes the treatment of RA patients with low-dose GCs through more efficient targeting of mediators of the immune/inflammatory reaction during the night to be available on arising. Circadian use of low-dose, long-term prednisone, by using night-release formulations (ingested at 10 to 11 p.m.) especially in early RA patients, appears characterized by a significantly superior efficacy on decreasing morning stiffness and IL-6 serum levels, compared to conventional daytime immediate-release prednisone. Shift from medium-dose, immediate-release prednisone (over 7.5-10 mg/day) to night-release formulations GC low-dose, long-term chronotherapy requires a gradual passage, since the hypothalamic-pituitary-adrenal axis of the treated RA patients, potentially altered by a negative feedback induced by the medium/high daily exogenous GC administration, needs time to re-synchronize control of endogenous GC production into a circadian and more physiological nocturnal hormone availability/optimized efficacy. PMID:25227591

Cutolo, Maurizio; Sulli, Alberto; Pincus, Theodore

2015-01-01

321

Endogenous thrombin potential for predicting risk of venous thromboembolism in carriers of factor V Leiden.  

PubMed

Measurement of endogenous thrombin potential (ETP) detects hypercoagulability and can be used to identify activated protein C resistance due to factor V Leiden (FVL). However, not all carriers of FVL suffer thrombosis and therefore we sought to determine if the test for ETP could be modified in such a way as to enable detection of FVL patients who were at increased risk of venous thromboembolism. Protac, an activator of both protein C and factor V, was incorporated into the traditional thrombin generation reaction and ratios (reaction with Protac:reaction without Protac) were calculated. Plasma samples from 42 FVL heterozygotes (12 with a history of thrombosis and 30 with no prior thrombosis) and 38 controls (non-FVL with no history of thrombosis) were analysed. The mean ETP ratio was significantly higher in FVL heterozygotes (0.90 +/- 0.06) compared to normal controls (0.41 +/- 0.10; p = 0.00004). Multivariate analysis indicated that the average ETP ratio was significantly and inversely correlated with factor V levels in FVL heterozygotes (p = 0.002) but not controls. Within the FVL group, patients with a history of thrombosis had higher ETP ratios (0.92 +/- 0.06) compared to those without (0.89 +/- 0.05), however, this did not reach statistical significance (p = 0.09). Further investigation into the use of ETP for detecting risk of thrombosis in people who are genetically predisposed is warranted. The recent introduction of diagnostic ETP measurements in the form of the calibrated automated thrombin generation from Thrombinoscope and the TechnoThrombin from Baxter should facilitate such studies. PMID:17565236

Lincz, Lisa F; Lonergan, Amy; Scorgie, Fiona E; Rowlings, Phillip; Gibson, Richard; Lawrie, Andrew; Seldon, Michael

2006-01-01

322

Congenital anomaly of the inferior vena cava and factor V Leiden mutation predisposing to deep vein thrombosis  

PubMed Central

A previously healthy 21-year-old man presented with back pain, bilateral extremity pain, and right lower extremity weakness, paresthesias, and swelling. Sonographic examination revealed diffuse deep vein thrombosis (DVT) in the femoral and popliteal venous system. CT imaging revealed hypoplasia of the hepatic inferior vena cava (IVC) segment with formation of multiple varices and collateral veins around the kidneys. Hematologic workup also discovered a factor V Leiden mutation, further predisposing the patient to DVT. The rare, often overlooked occurrence of attenuated IVC, especially in the setting of hypercoagulable state, can predispose patients to significant thrombosis. PMID:25395858

Lamparello, Brooke M; Erickson, Cameron R; Kulthia, Arun; Virparia, Vasudev; Thet, Zeyar

2014-01-01

323

Molecular imaging of rheumatoid arthritis: emerging markers, tools, and techniques  

PubMed Central

Early diagnosis and effective monitoring of rheumatoid arthritis (RA) are important for a positive outcome. Instant treatment often results in faster reduction of inflammation and, as a consequence, less structural damage. Anatomical imaging techniques have been in use for a long time, facilitating diagnosis and monitoring of RA. However, mere imaging of anatomical structures provides little information on the processes preceding changes in synovial tissue, cartilage, and bone. Molecular imaging might facilitate more effective diagnosis and monitoring in addition to providing new information on the disease pathogenesis. A limiting factor in the development of new molecular imaging techniques is the availability of suitable probes. Here, we review which cells and molecules can be targeted in the RA joint and discuss the advances that have been made in imaging of arthritis with a focus on such molecular targets as folate receptor, F4/80, macrophage mannose receptor, E-selectin, intercellular adhesion molecule-1, phosphatidylserine, and matrix metalloproteinases. In addition, we discuss a new tool that is being introduced in the field, namely the use of nanobodies as tracers. Finally, we describe additional molecules displaying specific features in joint inflammation and propose these as potential new molecular imaging targets, more specifically receptor activator of nuclear factor ?B and its ligand, chemokine receptors, vascular cell adhesion molecule-1, ?V?3 integrin, P2X7 receptor, suppression of tumorigenicity 2, dendritic cell-specific transmembrane protein, and osteoclast-stimulatory transmembrane protein. PMID:25099015

2014-01-01

324

Laboratory biomarkers or imaging in the diagnostics of rheumatoid arthritis?  

PubMed Central

Rheumatoid arthritis (RA) is a common autoimmune disease in which a heterogeneous course and different pathogenic mechanisms are implicated in chronic inflammation and joint destruction. Despite the diagnostic contribution of anti-citrullinated protein/peptide antibodies (ACPAs) and rheumatoid factors, about one-third of RA patients remain seronegative. ACPAs belong to a heterogeneous family of autoantibodies targeting citrullinated proteins, including myelin-basic protein, several histone proteins, filaggrin and fibrin, fibrinogen or vimentin. In addition to ACPAs, antibodies directed against other post-translationally modified-carbamylated proteins (anti-CarP) were detected in up to 30% of ACPA-negative patients. Using phage display technology, further autoantibodies were recently discovered as candidate biomarkers for seronegative RA patients. Furthermore, in clinical practice, ultrasound may reveal subclinical synovitis and radiographically undetected bone erosions. To improve diagnostic certainty in undifferentiated arthritis and seronegative patients, ultrasound imaging and several new biomarkers may help to identify at risk patients and those with early disease. In this commentary we summarize recent advances in joint ultrasound and future potential of serological biomarkers to improve diagnosis of RA. PMID:24642071

2014-01-01

325

Diagnostic properties of metabolic perturbations in rheumatoid arthritis  

PubMed Central

Introduction The aim of this study was to assess the feasibility of diagnosing early rheumatoid arthritis (RA) by measuring selected metabolic biomarkers. Methods We compared the metabolic profile of patients with RA with that of healthy controls and patients with psoriatic arthritis (PsoA). The metabolites were measured using two different chromatography-mass spectrometry platforms, thereby giving a broad overview of serum metabolites. The metabolic profiles of patient and control groups were compared using multivariate statistical analysis. The findings were validated in a follow-up study of RA patients and healthy volunteers. Results RA patients were diagnosed with a sensitivity of 93% and a specificity of 70% in a validation study using detection of 52 metabolites. Patients with RA or PsoA could be distinguished with a sensitivity of 90% and a specificity of 94%. Glyceric acid, D-ribofuranose and hypoxanthine were increased in RA patients, whereas histidine, threonic acid, methionine, cholesterol, asparagine and threonine were all decreased compared with healthy controls. Conclusions Metabolite profiling (metabolomics) is a potentially useful technique for diagnosing RA. The predictive value was without regard to the presence of antibodies against cyclic citrullinated peptides. PMID:21303541

2011-01-01

326

Insufficiency fractures of the distal tibia misdiagnosed as cellulitis in three patients with rheumatoid arthritis  

SciTech Connect

We describe 3 patients with rheumatoid arthritis who presented with diffuse pain, swelling, and erythema of the distal aspect of the lower extremity, suggestive of either cellulitis or thrombophlebitis, but were found to have insufficiency fractures of the distal tibia. The value of technetium-99m diphosphonate bone scintigraphy in the early recognition of these fractures and a possible explanation for the associated inflammatory symptoms are discussed.

Straaton, K.V.; Lopez-Mendez, A.; Alarcon, G.S. (Univ. of Alabama, Birmingham (USA))

1991-07-01

327

Primary septic arthritis of the manubriosternal joint in a heroin user  

SciTech Connect

A 20-year-old heroin user developed staphylococcus septic arthritis of the manubrium joint. The diagnosis was established by a culture of the infected tissue and blood culture. The clinical impression was aided by 99mTc radionuclide scintimetry. Early diagnosis localized the infection. Immediate antibiotic therapy solved a problem in the sternum that seems not to have been reported in the English literature.

Lopez-Longo, F.J.; Monteagudo, I.; Vaquero, F.J.; Martinez Moreno, J.L.; Carreno, L.

1986-01-01

328

The Impact of Arthritis on Canadian Women  

PubMed Central

Health Issue Arthritis is one of the most prevalent chronic conditions in Canada and a leading cause of long-term disability, pain, and increased health care utilization. It is also a far more prevalent condition among women than men. Information was obtained primarily from the 1998–99 National Population Health Survey and the Canadian Joint Replacement Registry. Key Findings In 1998, the overall prevalence of self-reported arthritis or rheumatism in Canadian women was 20.0%. This rate increased to 55.6% among women over 75 years of age. Compared to women with chronic conditions, women with arthritis were more likely to experience long-term disability; report worse health; experience more pain; be dependent upon others and consult general practitioners, specialists, and physiotherapists more frequently. While men and women with arthritis under-utilize total joint replacement surgery, the degree of under-use was over three times greater for women. Data Gaps and Recommendations There is a lack of detailed information on the use of health care services by women with arthritis. There are also no systematic data available on the prescribing of medications, access to services such as assistive devices or exercise programs, or use of community support, self-management strategies, or rehabilitation services. The burden of arthritis both on women and on society is expected to increase as the population ages. A comprehensive health strategy to reduce the impact of arthritis is required to ensure that health and support services are available in a timely manner and provided in such a way to meet the needs of Canadian women. PMID:15345081

Badley, Elizabeth M; Kasman, Naomi M

2004-01-01

329

Common Therapy for Rheumatoid Arthritis Reduces Risk of Death  

MedlinePLUS

... Common Therapy for Rheumatoid Arthritis Reduces Risk of Death Taking methotrexate—a commonly prescribed anti-inflammatory medication—may reduce the risk of death among patients with rheumatoid arthritis (RA), according to ...

330

A case of rheumatoid arthritis with unilateral knee synovial hypertrophy in hemiplegia.  

PubMed

A 64-year-old woman suffering right hemiplegia came in with pain and swelling on her left knee, general weakness and poor oral intake for 2 months. On physical examination we were able to palpate a mass with irregular margin around the left suprapatellar area. From the results of the magnetic resonance imaging (MRI), synovial proliferative disease, infectious arthritis, or gouty arthritis was suspected. We performed a blood laboratory test to detect rheumatologic diseases, knee joint aspiration, and bone scan for differential diagnosis, and were able to diagnose rheumatoid arthritis (RA) from the results of blood laboratory, physical examination, and bone scan. Consequently, we started medications for controlling RA. Herein, we report a case of rheumatoid arthritis with unilateral knee synovial hypertrophy in hemiplegia. If a right hemiplegic patient has recurrent pain on the left knee and synovial hypertrophy, and fails to respond to treatment for osteoarthritis, early detection by evaluation for rheumatic disease is crucial to prevent severe sequelae influencing rehabilitation of hemiplegia. PMID:22506248

Kim, Chan Woo; Kim, Mi Jung; Park, Si Bog; Han, Seung Hoon

2012-02-01

331

Validation of a Prediction Rule for the Diagnosis of Rheumatoid Arthritis in Patients with Recent Onset Undifferentiated Arthritis  

PubMed Central

Objectives. To validate van der Helm-van Mil score (vHvM) and new ACR/EULAR criteria for the diagnosis of rheumatoid arthritis (RA) in patients with undifferentiated arthritis (UA). Patients and Methods. Adult patients with UA (swelling ?2 joints of less than 6 months duration, without diagnosis, and never treated with disease modifying drugs). Results. Ninety-one patients were included. Mean age: 55.6 years (SD: 17.4), 74% females. Median symptoms duration was 2 months (IR: 1–4 months). Mean van der Helm-van Mil score was 6.9 (SD: 2). After a mean followup of 6.2 months (SD: 6), 40.7% patients fulfilled ACR 1987 RA classification criteria, 28.6% fulfilled other diagnostic criteria, and 31% remained as UA. Receiver operator characteristic curve's (ROC's) area under the curve (AUC) for the vHvM score for diagnosis of RA was 0.83. A cutoff value of 6.94 showed sensitivity of 81% and 79.7% specificity. For the new ACR/EULAR criteria, the ROC AUC was 0.93, and a value equal to or greater than 6 showed 86.5% sensitivity and 87% specificity. Conclusion. van der Helm-van Mil prediction score and the new ACR/EULAR criteria proved to be valuable for the diagnosis of RA in patients with early UA. PMID:23533423

Bedran, Zaida; Quiroz, Cristian; Rosa, Javier; Catoggio, Luis J.; Soriano, Enrique R.

2013-01-01

332

Comparative study of the synovial histology in rheumatoid arthritis, spondyloarthropathy, and osteoarthritis: influence of disease duration and activity  

Microsoft Academic Search

OBJECTIVESTo compare the macroscopic and microscopic characteristics of synovial tissue in rheumatoid arthritis (RA), spondyloarthropathy (SpA), and osteoarthritis (OA) after exclusion of possible biases induced by disease duration or activity, or both.METHODSSynovial biopsy specimens were obtained by needle arthroscopy in patients with early RA (n=16), late RA (n=14), early SpA (n=23), and OA (n=12). Macroscopic and microscopic features were scored

D Baeten; P Demetter; C Cuvelier; F Van den Bosch; E Kruithof; N Van Damme; G Verbruggen; H Mielants; E M Veys; F De Keyser

2000-01-01

333

Optimizing Long-Term Treatment of Rheumatoid Arthritis  

E-print Network

Optimizing Long-Term Treatment of Rheumatoid Arthritis with Systematic Documentation K. M. Simonic OF RHEUMATOID ARTHRITIS The whole body is plagued with pains. They ravage the joints in particular, so that foot Baillou, Liber de rheumatismo et pleuritide (1642) Rheumatoid arthritis [1] is an inflammatory systemic

Hammerton, James

334

Management of Rheumatoid Arthritis: Defining the Role of Leflunomide  

Microsoft Academic Search

Rheumatoid arthritis is a progressive, disabling disease which can lead to long-term deformity and disability. Leflunomide is a disease-modifying antirheumatic drug (DMARD) approved to reduce signs and symptoms, inhibit structural damage and improve physical function in adults with active rheumatoid arthritis. In clinical trials in patients with active rheumatoid arthritis, leflunomide had a more rapid onset of action than methotrexate,

Christopher I. Carswell; Caroline M. Perry; Tim Ibbotson

2003-01-01

335

38 CFR 4.58 - Arthritis due to strain.  

Code of Federal Regulations, 2013 CFR

...2013-07-01 2013-07-01 false Arthritis due to strain. 4.58 Section 4...The Musculoskeletal System § 4.58 Arthritis due to strain. With service incurred...amputation or shortening, a disabling arthritis, developing in the same...

2013-07-01

336

ARTHRITIS & RHEUMATISM Vol. 60, No. 8, August 2009, pp 22422247  

E-print Network

ARTHRITIS & RHEUMATISM Vol. 60, No. 8, August 2009, pp 2242­2247 DOI 10.1002/art.24721 © 2009 of Joint Destruction in Rheumatoid Arthritis Michael P. M. van der Linden,1 Anouk L. Feitsma,1 Saskia le of joint destruction in rheumatoid arthritis (RA) is highly variable from pa- tient to patient

Raychaudhuri, Soumya

337

38 CFR 4.58 - Arthritis due to strain.  

...2014-07-01 2014-07-01 false Arthritis due to strain. 4.58 Section 4...The Musculoskeletal System § 4.58 Arthritis due to strain. With service incurred...amputation or shortening, a disabling arthritis, developing in the same...

2014-07-01

338

Study of a prevention programme for caprine arthritis-encephalitis  

E-print Network

Study of a prevention programme for caprine arthritis-encephalitis G Péretz F Bugnard D Calavas; A prevention programme for caprine viral arthritis-encephalitis was monitored in 363 goat herds between 1988 transmission. goat / caprine arthritis-encephalitis virus / prevention Résumé ― Ã?tude d'un programme de

Paris-Sud XI, Université de

339

38 CFR 4.58 - Arthritis due to strain.  

Code of Federal Regulations, 2012 CFR

...2012-07-01 2012-07-01 false Arthritis due to strain. 4.58 Section 4...The Musculoskeletal System § 4.58 Arthritis due to strain. With service incurred...amputation or shortening, a disabling arthritis, developing in the same...

2012-07-01

340

Arthritis associated with inflammatory bowel disease in children  

Microsoft Academic Search

The records of 102 children with inflammatory bowel disease (44 with ulcerative colitis, 58 with Crohn's disease) were reviewed for evidence of joint disease unassociated with erythema nodosum. Thirteen children had arthritis, four had ulcerative colitis, and nine had Crohn's disease. Arthritis tended to be pauciarticular; ankles, knees, elbows and hips were most commonly affected. In three patients arthritis preceded

Murray H. Passo; Joseph F. Fitzgerald; Kenneth D. Brandt

1986-01-01

341

Pemetrexed ameliorates experimental arthritis in rats.  

PubMed

Pemetrexed (PMTX) is an anti-folate drug as methotrexate. The purpose of this study was to assess the efficacy of PMTX on collagen-induced arthritis (CIA). Forty Wistar albino rats were randomized into four groups. Arthritis was induced by intradermal injection of chicken type II collagen combined with incomplete Freund's adjuvant. Animals were sacrificed at the 15th day after the onset of arthritis. Tumor necrosis factor alpha (TNF-?), interleukin (IL)-17, and malondialdehyde (MDA) levels were increased, and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities and the expressions of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were decreased in the arthritis group. In the PMTX-treated (0.2 and 1 mg/kg/week i.p.) groups, the levels of TNF-?, IL-17, and MDA were decreased; the activities of SOD, CAT, and GPx and the expressions of Nrf2 and HO-1 were restored, and perisynovial inflammation and cartilage-bone destruction were decreased. PMTX has anti-arthritic potential in the CIA model and may be a therapeutic agent for rheumatoid arthritis. PMID:25129058

Karatas, Ahmet; Koca, Suleyman Serdar; Ozgen, Metin; Dagli, Adile Ferda; Erman, Fazilet; Sahin, Nuran; Sahin, Kazim; Isik, Ahmet

2015-02-01

342

[Osteoscintigraphy in the diagnosis of psoriatic arthritis].  

PubMed

The authors presented the results of clinical, x-ray and osteoscintigraphic investigations of 133 psoriatic arthritis patients and 72 patients with common psoriasis. Osteoscintigraphy was performed using a routine method with 99mTc-pyrophos (USSR) and 99mTc-phosphone (Hungary) on gamma-camera LFOV (Nuclear-Chicago, USA). X-ray signs of the involvement of the osteoarticular system were noted in 69 (51%) patients with psoriatic arthritis and in 16 (22%) patients with common psoriasis. The method permitted the detection of the foci of RP hyperfixation in 129 (97%) patients with psoriatic arthritis and in 51 (70.8%) patients with common psoriasis. They were observed mostly in large and small limb joints, less frequently--in the vertebral column, cranial bones, thorax, and ribs. Thus, osteoscintigraphy is a highly sensitive method for the detection of active inflammatory foci of the osteoarticular system in psoriasis at all stages of arthritis development. It makes it possible to detect the spreading of arthritis and its preclinical forms. PMID:2537452

Milevskaia, S G; Borodulin, V G

1989-02-01

343

The microbiome and rheumatoid arthritis  

PubMed Central

Humans are not (and have never been) alone. From the moment we are born, millions of micro-organisms populate our bodies and coexist with us rather peacefully for the rest of our lives. This microbiome represents the totality of micro-organisms (and their genomes) that we necessarily acquire from the environment. Micro-organisms living in or on us have evolved to extract the energy they require to survive, and in exchange they support the physiological, metabolic and immune capacities that have contributed to our evolutionary success. Although currently categorized as an autoimmune disorder and regarded as a complex genetic disease, the ultimate cause of rheumatoid arthritis (RA) remains elusive. It seems that interplay between predisposing genetic factors and environmental triggers is required for disease manifestation. New insights from DNA sequence-based analyses of gut microbial communities and a renewed interest in mucosal immunology suggest that the microbiome represents an important environmental factor that can influence autoimmune disease manifestation. This Review summarizes the historical clues that suggest a possible role for the microbiota in the pathogenesis of RA, and will focus on new technologies that might provide scientific evidence to support this hypothesis. PMID:21862983

Scher, Jose U.; Abramson, Steven B.

2012-01-01

344

HLA-linked rheumatoid arthritis.  

PubMed Central

Twenty-eight pedigrees were ascertained through pairs of first-degree relatives diagnosed with rheumatoid arthritis (RA). RA was confirmed in 77 pedigree members including probands; the absence of disease was verified in an additional 261 pedigree members. Pedigree members were serologically typed for HLA. We used likelihood analysis to statistically characterize the HLA-linked RA susceptibility locus. The genetic model assumed tight linkage to HLA. The analysis supported the existence of an HLA-linked RA susceptibility locus, estimated the susceptibility allele frequency as 2.16%, and estimated the lifetime penetrance as 41% in male homozygotes and as 48% in female homozygotes. Inheritance was recessive in males and was nearly recessive in females. In addition, the analysis attributed 78% of the variance within genotypes to genetic or environmental effects shared by siblings. The genetic model inferred in this analysis is consistent with previous association, linkage, and familial aggregation studies of RA. The inferred HLA-linked RA susceptibility locus accounts for approximately one-half of familial RA, although it accounts for only approximately one-fifth of the RA in the population. Although other genes may account for the remaining familial RA, a large portion of RA cases may occur sporadically. PMID:7942852

Hasstedt, S. J.; Clegg, D. O.; Ingles, L.; Ward, R. H.

1994-01-01

345

HLA-linked rheumatoid arthritis  

SciTech Connect

Twenty-eight pedigrees were ascertained through pairs of first-degree relatives diagnosed with rheumatoid arthritis (RA). RA was confirmed in 77 pedigree members including probands; the absence of disease was verified in an additional 261 pedigree members. Pedigree members were serologically typed for HLA. We used likelihood analysis to statistically characterize the HLA-linked RA susceptibility locus. The genetic model assumed tight linkage to HLA. The analysis supported the existence of an HLA-linked RA susceptibility locus, estimated the lifetime penetrance as 41% in male homozygotes and as 48% in female homozygotes. Inheritance was recessive in males and was nearly recessive in females. In addition, the analysis attributed 78% of the variance within genotypes to genetic or environmental effects shared by siblings. The genetic model inferred in this analysis is consistent with previous association, linkage, and familial aggregation studies of RA. The inferred HLA-linked RA susceptibility locus accounts for approximately one-fifth of the RA in the population. Although other genes may account for the remaining familial RA, a large portion of RA cases may occur sporadically. 79 refs., 9 tabs.

Hasstedt, S.J.; Clegg, D.O.; Ingles, L.; Ward, R.H. [Univ. of Utah, Salt Lake City, UT (United States)

1994-10-01

346

Gene Profiling of Chikungunya Virus Arthritis in a Mouse Model Reveals Significant Overlap With Rheumatoid Arthritis  

PubMed Central

Objective Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes a chronic debilitating polyarthralgia/polyarthritis, for which current treatments are often inadequate. To assess whether new drugs being developed for rheumatoid arthritis (RA) might find utility in the treatment of alphaviral arthritides, we sought to determine whether the inflammatory gene expression signature of CHIKV arthritis shows any similarities with RA or collagen-induced arthritis (CIA), a mouse model of RA. Methods Using a recently developed animal model of CHIKV arthritis in adult wild-type mice, we generated a consensus CHIKV arthritis gene expression signature, which was used to interrogate publicly available microarray studies of RA and CIA. Pathway analyses were then performed using the overlapping gene signatures. Results Gene set enrichment analysis showed that there was a highly significant overlap in the differentially expressed genes in the CHIKV arthritis model and in RA. This concordance also increased with the severity of RA, as measured by the inflammation score. A highly significant overlap was also seen between CHIKV arthritis and CIA. Pathway analysis revealed that the overlap between these arthritides was spread over a range of different inflammatory processes. Involvement of T cells and interferon-? (IFN?) in CHIKV arthritis was confirmed in studies of MHCII-deficient mice and IFN?-deficient mice, respectively. Conclusion These results suggest that RA, a chronic autoimmune arthritis, and CHIKV disease, usually a self-limiting viral arthropathy, share multiple inflammatory processes. New drugs and biologic therapies being developed for RA may thus find application in the treatment of alphaviral arthritides. PMID:22833339

Nakaya, Helder I.; Gardner, Joy; Poo, Yee-Suan; Major, Lee; Pulendran, Bali; Suhrbier, Andreas

2013-01-01

347

Epidemiology of proctocolitis in the region of Leiden, The Netherlands. A population study from 1979 to 1983.  

PubMed

An epidemiologic study of proctocolitis in the Leiden Health Care Region was conducted between 1979 and 1983. One hundred and seven cases were diagnosed before 1979 and 150 between 1979 and 1983. Most of the patients had proctocolitis (42%), and only 11% had pancolitis. The incidence was 6.8/10(5)/year and was similar in men and women. There was no specific age group at additional risk of developing the disease. The prevalence was 58.4/10(5). Patients with proctocolitis tended to live in country or city areas; people living in dormitory suburbs were at a reduced risk (chi-square test, p less than 0.001). However, there was a significant difference in incidence between Leiden (10.8/10(5)/year) and Alphen (4.1/10(5)/year) (corrected chi-square = 7.3; p less than 0.001). This was also true for the prevalence in these two cities. The prevalence of the disease in migrants (85.3/10(5)) was not significantly different from that in the indigenous population (58/10(5)). PMID:3685885

Shivananda, S; Peña, A S; Mayberry, J F; Ruitenberg, E J; Hoedemaeker, P J

1987-10-01

348

Differential effects of amlodipine and atorvastatin treatment and their combination on atherosclerosis in ApoE*3-Leiden transgenic mice.  

PubMed

This study was designed to investigate the potential antiatherosclerotic effects of the calcium antagonist amlodipine as compared with the HMG-CoA reductase inhibitor atorvastatin and the combination of both in ApoE*3-Leiden transgenic mice. Four groups of 15 ApoE*3-Leiden mice were put on a high-cholesterol diet. One group received 0.002% (wt/wt) amlodipine in the diet, which had no effect on plasma cholesterol levels. Another group received 0.01% (wt/wt) atorvastatin, resulting in a decrease of plasma cholesterol by 50% by a reduction in very low density lipoprotein production. The combination group received both amlodipine and atorvastatin. After 28 weeks, atherosclerosis in the aortic root was quantified. Treatment with amlodipine had no significant effect on atherosclerotic lesion area, whereas atorvastatin markedly reduced atherosclerosis by 77% compared with the control group. Atorvastatin also reduced inflammation markers. The combination of amlodipine and atorvastatin tended to reduce lesion area by 61% compared with the atorvastatin-only group; however, this effect did not reach statistical significance. Amlodipine treatment significantly reduced calcification in the lesions, whereas atorvastatin alone had no effect. The combination of amlodipine and atorvastatin resulted in a near absence of calcium deposits in the lesions. This study demonstrates that amlodipine treatment alone does not significantly reduce atherosclerotic lesion development. Atorvastatin was shown to have strong antiatherosclerotic effects, and cotreatment with amlodipine may potentiate the antiatherosclerotic effect of atorvastatin. PMID:12827028

Delsing, Dianne J M; Jukema, J Wouter; van de Wiel, Mark A; Emeis, Jef J; van der Laarse, Arnoud; Havekes, Louis M; Princen, Hans M G

2003-07-01

349

PTPRC rheumatoid arthritis risk allele is also associated with response to anti-TNF therapy  

E-print Network

. Karlson1 , and Robert M. Plenge1,3 1. Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA USA. 2. Rheumatology Unit, Department of Medicine, Karolinska Institutet of Rheumatology, Leiden University Medical Centre, 2333 ZA Leiden, The Netherlands. 5. Rosalind Russell Medical

Raychaudhuri, Soumya

350

Genome-wide association study meta-analysis identifies 7 novel rheumatoid arthritis risk loci  

E-print Network

* these authors contributed equally 1. Division of Rheumatology, Immunology, and Allergy, Brigham and Women of Rheumatology, Leiden University Medical Centre, 2333 ZA Leiden, The Netherlands. 17. The Feinstein Institute. Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Solna

de Bakker, Paul

351

The schizophrenia-rheumatoid arthritis connection: infectious, immune, or both?  

PubMed

Schizophrenia and rheumatoid arthritis share an impressive number of similarities. Both are chronic, relapsing diseases of unknown etiology. Both became prominent in the early 19th century and have prevalences of approximately 1% in North America and Europe. Both run in families, have pairwise concordance rates of approximately 30% among monozygotic twins, and are more common among individuals born in urban areas. For both diseases, studies have reported greater exposure to cats in childhood than in controls. Both diseases have been associated with similar class II HLA antigens. Both have also been suspected of having infectious etiology, with similar agents--retroviruses, herpesviruses including EBV, and Toxoplasma gondii--having been associated in some cases. Since there is also a well-documented inverse correlation between these two diseases, it is possible that they share a common infectious and/or immune etiology and that once a person gets one of the diseases then they are relatively immune to the other. PMID:11782106

Torrey, E F; Yolken, R H

2001-12-01

352

Importance of adherence in the outcome of juvenile idiopathic arthritis.  

PubMed

Medical treatment of juvenile idiopathic arthritis (JIA) has advanced in the last decade, and improved prognosis is a reality in daily clinical practice. Despite this improvement in the quality of treatment, the outcome can still be compromised by modifiable factors, including delayed referral to a specialist, delayed drug treatment, poor adherence to treatment, and early interruption of drug treatment. In this review we discuss the most relevant aspects related to adherence to treatment in JIA, with emphasis on: factors that affect adherence to treatment; effect of poor adherence to treatment on JIA prognosis; when to suspect and how to assess poor adherence to treatment; and strategies to promote adherence to treatment, with an emphasis on information-reinforcement education. Besides presenting the findings of other authors, we also try to report our experience of this subject, which is still a challenge for health professionals. PMID:24504596

Len, Claudio A; Miotto e Silva, Vanessa B; Terreri, Maria Teresa R A

2014-04-01

353

Chondroprotective effect of betamethasone in lapine pyogenic arthritis.  

PubMed

The chondroprotective effect of betamethasone was examined to determine if corticosteroids can decrease articular cartilage injury caused by inflammatory exudate in Staphylococcus aureus gonarthritis in rabbits. Three experimental groups of antibiotic-treated rabbits were created, comparing parenteral versus low-dose intraarticular routes of betamethasone administration. Rabbits that received ceftriaxone plus supplemental parenteral betamethasone (group 2) demonstrated significantly less articular cartilage proteoglycan loss than did rabbits treated with antibiotics alone (group 1). Supplemental intraarticular betamethasone (group 3) was somewhat less effective in this regard, possibly reflecting the smaller steroid dosage. This animal study introduces histologic and biochemical evidence that betamethasone, administered early and in conjunction with appropriate systemic antibiotics, may help protect infected articular cartilage from proteolytic degradation. Further study is needed to prove safety and efficacy of corticosteroids before recommending their clinical use in the treatment of septic arthritis. PMID:8742291

Stricker, S J; Lozman, P R; Makowski, A L; Gunja-Smith, Z

1996-01-01

354

Cricoarytenoid arthritis: a cause of acute upper airway obstruction in rheumatoid arthritis  

Microsoft Academic Search

Purpose  To report acute upper airway obstruction due to cricoarytenoid arthritis, a well known but uncommon complication of rheumatoid\\u000a arthritis.\\u000a \\u000a \\u000a \\u000a Clinical features  We report the case of a 70-yr-old female scheduled for a colostomy who had been suffering from rheumatoid arthritis for 17\\u000a years. Preoperative history and physical examination revealed no cardiopulmonary compromise. Anesthesia was induced while\\u000a an assistant immobilized the cervical

Jacelyn Kolman; Ian Morris

2002-01-01

355

Economics of stratified medicine in rheumatoid arthritis.  

PubMed

Clinically relevant examples of stratified medicine are available for patients with rheumatoid arthritis (RA). The aim of this study was to understand the current economic evidence for stratified medicine in RA. Two systematic reviews were conducted to identify: (1) all economic evaluations of stratified treatments for rheumatoid arthritis, or those which have used a subgroup analysis, and (2) all stated preference studies of treatments for rheumatoid arthritis. Ten economic evaluations of stratified treatments for RA, 38 economic evaluations including with a subgroup analysis and eight stated preference studies were identified. There was some evidence to support that stratified approaches to treating a patient with RA may be cost-effective. However, there remain key gaps in the economic evidence base needed to support the introduction of stratified medicine in RA into healthcare systems and considerable uncertainty about how proposed stratified approaches will impact future patient preferences, outcomes and costs when used in routine practice. PMID:25366935

Gavan, Sean; Harrison, Mark; Iglesias, Cynthia; Barton, Anne; Manca, Andrea; Payne, Katherine

2014-12-01

356

Apremilast for the treatment of psoriatic arthritis.  

PubMed

Psoriatic arthritis occurs in about one-third of patients with psoriasis, and is a severely disabling, progressive inflammatory spondyloarthropathy typically treated with non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, TNF-? inhibitors and ustekinumab. These medications moderately improve the arthritis, dactylitis, and enthesitis that characterize psoriatic arthritis, however, they are associated with serious long-term adverse effects, issues with safety and tolerability, and high cost. Moreover, many patients do not respond or have resistant or recurrent manifestations to these agents. Apremilast is an orally available phosphodiesterase type 4 inhibitor that may block the pathogenic inflammatory Th17 and Th1 pathways upstream of current biologics, which target extracellular molecules of the immunological response. PMID:24702658

Varada, Sowmya; Tintle, Suzanne J; Gottlieb, Alice B

2014-05-01

357

Rheumatoid arthritis in population samples in Iraq.  

PubMed Central

A prevalence survey for rheumatoid arthritis was carried out during the summer of 1975 in persons aged 16 years and over in areas of Iraq representative of differences in geography and ethnicity. Definite rheumatoid arthritis was observed in 1% of the 6999 individuals studied, but differences in occurrence rates in relation to various associated characteristics were not detected. It is concluded that present rheumatological services in Iraq have not developed in response to the magnitude of the existing burden. Morning stiffness was reported fairly frequently by individuals without rheumatoid arthritis, but the significance of this observation is not easy to determine. Raynaud's phenomenon was also recorded, but comparative evaluation of the findings is not possible. PMID:629609

Al-Rawi, Z S; Alazzawi, A J; Alajili, F M; Alwakil, R

1978-01-01

358

Composite measures in psoriatic arthritis: GRAPPA 2008.  

PubMed

At the 2008 annual meeting of GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis) in Leeds, UK, members discussed the value and current status of composite measures for the assessment of psoriatic arthritis (PsA). In plenary presentations, examples of composite measures developed for rheumatoid arthritis (RA) and ankylosing spondylitis (AS) were reviewed, followed by a presentation of the assessment of disease activity in systemic lupus erythematosus. Three recently devised composite methods of assessing activity or response in PsA also were presented. Considerable discussion followed in breakout groups, and members agreed that a new composite measure specifically for PsA is necessary. The composite measure should include components that encompass the spectrum of psoriatic disease, i.e., in addition to assessment of peripheral joints, it should include assessment of sacroiliitis, spondylitis, enthesitis, and dactylitis, as well as skin and nail disease. PMID:20147481

Gladman, Dafna D; Landewé, Robert; McHugh, Neil J; Fitzgerald, Oliver; Thaci, Diamant; Coates, Laura; Mease, Philip J; Qureshi, Abrar A; Krueger, Gerald G; Ritchlin, Christopher T; Kavanaugh, Arthur F; Garg, Amit

2010-02-01

359

A comparison of region-based and pixel-based CEUS kinetics parameters in the assessment of arthritis  

NASA Astrophysics Data System (ADS)

Inflammatory rheumatic diseases are leading causes of disability and constitute a frequent medical disorder, leading to inability to work, high comorbidity and increased mortality. The gold-standard for diagnosing and differentiating arthritis is based on patient conditions and radiographic findings, as joint erosions or decalcification. However, early signs of arthritis are joint effusion, hypervascularization and synovial hypertrophy. In particular, vascularization has been shown to correlate with arthritis' destructive behavior, more than clinical assessment. Contrast Enhanced Ultrasound (CEUS) examination of the small joints is emerging as a sensitive tool for assessing vascularization and disease activity. The evaluation of perfusion pattern rely on subjective semi-quantitative scales, that are able to capture the macroscopic degree of vascularization, but are unable to detect the subtler differences in kinetics perfusion parameters that might lead to a deeper understanding of disease progression and a better management of patients. Quantitative assessment is mostly performed by means of the Qontrast software package, that requires the user to define a region of interest, whose mean intensity curve is fitted with an exponential function. We show that using a more physiologically motivated perfusion curve, and by estimating the kinetics parameters separately pixel per pixel, the quantitative information gathered is able to differentiate more effectively different perfusion patterns. In particular, we will show that a pixel-based analysis is able to provide significant markers differentiating rheumatoid arthritis from simil-rheumatoid psoriatic arthritis, that have non-significant differences in clinical evaluation (DAS28), serological markers, or region-based parameters.

Grisan, E.; Raffeiner, B.; Coran, A.; Rizzo, G.; Ciprian, L.; Stramare, R.

2014-03-01

360

Extraspinal tuberculous arthritis in HIV era.  

PubMed

A worldwide reemergence of tuberculosis is appreciable. Extrapulmonary tuberculosis has been observed to increase disproportionately from past incidence. One of the main attributing factors is the human immunodeficiency virus (HIV) infection. The objective of this study was to study clinical features, laboratory findings, and association with HIV infection in patients with peripheral tuberculous arthritis. The retrospective study was performed by reviewing the medical records of 27 patients with extraspinal tuberculous arthritis treated from January 1994 to December 2002. The diagnosis was made either by compatible clinical presentation and positive culture for Mycobacterium tuberculosis or histological finding of caseating granuloma in biopsy tissue or both. The average age of the patients' population was 49.3 years (range 27-74 years), made up of a 52% or 14 patients of male subjects. The mean duration of disease before seeking medical treatment was 10.2+11 weeks and from onset to diagnosis was 25 weeks. The most frequently affected joints were knees (36.6%) followed by wrists, ankles, shoulders, hips, sacroiliacs, and elbows, respectively. Monoarthritis was the main feature of this group, except for two patients who had two and three joints involvement, respectively. Dactylitis (tenosynovitis) was also found in two out of the 27 patients. Six patients (24%) had active pulmonary infiltration on chest X-ray. Of 11 patients with synovial polymerase chain reaction (PCR) testing for tuberculosis, seven patients had positive result. Only one patient with extraspinal tuberculous arthritis tested positive for HIV. Therefore, extraspinal tuberculous arthritis is observed to be usually present with chronic monoarthritis. The diagnosis is delayed in most occasions. PCR from synovial fluid may facilitate rapid diagnosis of tuberculous arthritis. Human immunodeficiency virus may not be a main contributing factor for extraspinal tuberculous arthritis. PMID:16642407

Lertsrisatit, P; Nantiruj, K; Totemchokchyakarn, K; Janwityanujit, S

2007-03-01

361

Spontaneous Coronary Artery Dissection in a Young Man with a Factor V Leiden Gene Mutation: A Case Report and Review of the Literature  

PubMed Central

Spontaneous coronary artery dissection is a rare but increasingly recognized cause of acute myocardial ischemia in young adults, especially in women. We report a case of spontaneous coronary dissection in a young healthy man who was also a carrier of the factor V Leiden gene mutation. PMID:24436622

Khan, Tahir; Danyi, Peter; Topaz, On; Ali, Asghar; Jovin, Ion S.

2013-01-01

362

Spontaneous coronary artery dissection in a young man with a factor v leiden gene mutation: a case report and review of the literature.  

PubMed

Spontaneous coronary artery dissection is a rare but increasingly recognized cause of acute myocardial ischemia in young adults, especially in women. We report a case of spontaneous coronary dissection in a young healthy man who was also a carrier of the factor V Leiden gene mutation. PMID:24436622

Khan, Tahir; Danyi, Peter; Topaz, On; Ali, Asghar; Jovin, Ion S

2013-12-01

363

Forthcoming in: Rint Sybesma, Wolfgang Behr, Zev Handel & C.T. James Huang (eds.), Encyclopedia of Chinese Language and Linguistics. Leiden: Brill.  

E-print Network

of Chinese Language and Linguistics. Leiden: Brill. Authors: Alexis Michaud & Guillaume Jacques. André scientifique, in the Botany department; he switched to the Linguistics department in 1945. His special interest little-documented languages within their cultural environment, combining ethnological and linguistic work

364

New coagulation factor V gene polymorphisms define a single and infrequent haplotype underlying the factor V Leiden mutation in Mediterranean populations and Indians.  

PubMed

Two novel polymorphisms were identified in the factor V gene by direct sequencing of intronic areas. One of them, located in intron 9, is the marker closest to the Leiden mutation ever described, whereas the other, in intron 16, displays a rare allele invariantly associated to the mutation. Allele-specific amplification protocols were designed to perform extensive screenings for both polymorphic sites. The new markers were used in combination with six previously described polymorphisms to define specific factor V gene haplotypes. Haplotype investigations in 506Q homozygous thrombotic patients and normal controls showed the presence of a single haplotype underlying the factor V Leiden mutation in Mediterranean populations (among which Greek Cypriots, where the R506Q mutation is particularly frequent) and Indians. When traced in the absence of the Leiden mutation, the background haplotype was found to be present and roughly as frequent as the mutation itself in these populations. These findings indicate a single mutational event, that probably occurred outside Europe, as the cause of the Leiden mutation and provide a powerful tool to investigate its evolutionary history. PMID:9308750

Castoldi, E; Lunghi, B; Mingozzi, F; Ioannou, P; Marchetti, G; Bernardi, F

1997-09-01

365

Cardiovascular Risk in Patients with Psoriatic Arthritis  

PubMed Central

Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. In addition to skin and joint involvement, there is increasing evidence suggesting that patients with PsA also have an increase in risk of clinical and subclinical cardiovascular diseases, mostly due to accelerating atherosclerosis. Both conventional and nonconventional cardiovascular risk factors contribute to the increased cardiovascular risk in PsA. Chronic inflammation plays a pivotal role in the pathogenesis of atherosclerosis in PsA, acting independently and/or synergistically with the conventional risk factors. In this paper, we discuss the current literature indicating that patients with PsA are at risk of cardiovascular diseases. PMID:22645614

Zhu, Tracy Y.; Li, Edmund K.; Tam, Lai-Shan

2012-01-01

366

Cardiovascular risk in patients with psoriatic arthritis.  

PubMed

Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. In addition to skin and joint involvement, there is increasing evidence suggesting that patients with PsA also have an increase in risk of clinical and subclinical cardiovascular diseases, mostly due to accelerating atherosclerosis. Both conventional and nonconventional cardiovascular risk factors contribute to the increased cardiovascular risk in PsA. Chronic inflammation plays a pivotal role in the pathogenesis of atherosclerosis in PsA, acting independently and/or synergistically with the conventional risk factors. In this paper, we discuss the current literature indicating that patients with PsA are at risk of cardiovascular diseases. PMID:22645614

Zhu, Tracy Y; Li, Edmund K; Tam, Lai-Shan

2012-01-01

367

Total Knee Arthroplasty Considerations in Rheumatoid Arthritis  

PubMed Central

The definitive treatment for advanced joint destruction in the late stages of rheumatoid arthritis can be successfully treated with total joint arthroplasty. Total knee arthroplasty has been shown to be a well-proven modality that can provide pain relief and restoration of mobility for those with debilitating knee arthritis. It is important for rheumatologists and orthopedic surgeons alike to share an understanding of the special considerations that must be addressed in this unique population of patients to ensure success in the immediate perioperative and postoperative periods including specific modalities to maximize success. PMID:24151549

Danoff, Jonathan R.; Geller, Jeffrey A.

2013-01-01

368

Anterior cruciate ligament rupture in gouty arthritis.  

PubMed

A 34-year-old male presented with right knee instability without any trauma. He had been diagnosed with right knee gouty arthritis 2 years prior. An arthroscopic examination revealed abundant calcific material deposited around the knee joint, including in the ACL tissue, and that the ACL was torn at the femoral attachment site. Treatment involved a synovectomy to remove calcific material, followed by an ACL reconstruction. Histology evaluation revealed gouty arthritis with the presence of tophi in the synovium, soft tissue, and ACL tissue. The case presented here indicates the possibility of pathologic rupture of the ACL associated with gouty tophus infiltration of that ligament. Level of evidence IV. PMID:22048747

Hwang, Hyun-Jung; Lee, Soon-Hyuck; Han, Seung-Beom; Park, Si-Young; Jeong, Woong-Kyo; Kim, Chul-Hwan; Lee, Dae-Hee

2012-08-01

369

A case of erythema nodosum with arthritis.  

PubMed

A 33-year-old Caucasian woman presented 6 months postpartum with acute sarcoid arthritis with interstitial lung disease and minimal hilar adenopathy. Nine years before, she had experienced transient ankle arthritis and erythema nodosum. Her chest radiograph at that time was normal, and her symptoms were attributed then to initiation of the birth control pill. It appears that this patient had an incomplete Lofgren's syndrome, which might have initially occurred nearly a decade before a diagnosis of pulmonary sarcoidosis was made. Her sarcoidosis has improved, and she appears to have a good prognosis, which is typical of Lofgren's syndrome. PMID:19078102

Pope, J E; McCormack, D

1996-12-01

370

Pneumococcal septic arthritis as the initial presentation of multiple myeloma.  

PubMed

Septic arthritis induced by Streptococcus pneumoniae is an uncommon manifestation of pneumococcal infection. Pneumococcus has been identified as the inciting pathogen in only 6% of cases of septic arthritis in recent retrospective studies (Ross et al., 2003). Approximately 50% of patients with pneumococcal septic arthritis have a preceding or concurrent extra-articular focus of infection. The septic joint evolves from hematogenous seeding of the highly vascular synovial membrane by bacteria. Polyarticular disease occurs in only approximately 36% of patients. Most pneumococcal septic arthritis occurs with coexistant joint disease, prosthesis, alcoholism, HIV infection, or rheumatoid arthritis (Baraboutis & Skoutelis, 2004; Raad & Peacock, 2004). We report a case of polyarticular septic arthritis as the first manifestation of an underlying disease. Our literature review discloses that this is the first reported case of multiple myeloma initially presenting as pneumococcal septic arthritis in the USA and the third internationally (Cuesta et al., 1992; Renou et al., 2007). PMID:18190474

Sumrall, A; Muzny, C; Bell, J; Dreiling, B

2008-02-01

371

A case of methimazole-induced chronic arthritis masquerading as seronegative rheumatoid arthritis.  

PubMed

We report a 40-year-old woman with onset of oligoarthritis shortly after initiating treatment with methimazole for Graves disease. Over the course of 7 years, her arthritis became progressively severe, leading to a diagnosis of seronegative rheumatoid arthritis. Treatment with disease-modifying antirheumatic agents and surgical intervention was contemplated. Ultrasound and magnetic resonance imaging revealed exuberant synovitis, involving right elbow and knees. Upon withdrawal of methimazole, prompt resolution of all signs and symptoms of arthritis was observed within several weeks. Following a MEDLINE search of available literature concerning antithyroid drug-induced arthritis, it is evident that this case represents the lengthiest duration of inflammatory arthropathy ever described in a patient that nonetheless was rapidly reversible with discontinuation of methimazole. PMID:24847752

Gruber, Conor N; Finzel, Kathleen; Gruber, Barry L

2014-06-01

372

X-linked agammaglobulinemia combined with juvenile idiopathic arthritis and invasive Klebsiella pneumoniae polyarticular septic arthritis.  

PubMed

X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disease caused by mutations in the Bruton's tyrosine kinase (BTK) gene. XLA can also present in combination with juvenile idiopathic arthritis (JIA), the major chronic rheumatologic disease in children. We report herein the first known case of a juvenile patient diagnosed with XLA combined with JIA that later developed into invasive Klebsiella pneumoniae polyarticular septic polyarthritis. An additional comprehensive review of XLA combined with JIA and invasive K. pneumoniae septic arthritis is also presented. XLA was identified by the detection of BTK mutations while the diagnosis of JIA was established by clinical and laboratory assessments. Septic arthritis caused by invasive K. pneumoniae was confirmed by culturing of the synovia and gene detection of the isolates. Invasive K. pneumoniae infections can not only result in liver abscesses but also septic arthritis, although this is rare. XLA combined with JIA may contribute to invasive K. pneumoniae infection. PMID:24567239

Zhu, Zaihua; Kang, Yuli; Lin, Zhenlang; Huang, Yanjing; Lv, Huoyang; Li, Yasong

2015-02-01

373

Primary thrombophilia in Mexico. II. Factor V G1691A (Leiden), prothrombin G20210A, and methylenetetrahydrofolate reductase C677T polymorphism in thrombophilic Mexican mestizos.  

PubMed

We have shown that in Mexican mestizo patients with clinical features of primary thrombophilia, 39% have activated protein C resistance phenotype, 5% protein C deficiency, and 2% protein S deficiency. In the present study, in a group of 37 thrombophilic Mexicans and 50 normal controls, we assessed the factor V G1691A (Leiden), the prothrombin G20210A, and the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphisms. Four patients were found to be heterozygous for factor V Leiden, 5 heterozygous for the prothrombin 20210, 16 heterozygous, and 6 homozygous for the MTHFR 677. There were four individuals with co-segregation of alleles: two heterozygotes for the factor V Leiden/prothrombin 20210, one heterozygote for prothrombin 20210/MTHFR 677, and one heterozygote for prothrombin 20210/homozygote for MTHFR 677. For factor V Leiden, prothrombin 20210, and MTHFR 677 mutations, the allele frequencies were respectively 1% (+/-0.2%, alpha = 0.05), <1% and 51% (+/-5%, alpha = 0.05), with calculated relative risks for thrombosis of 5.94 (P = 0.08), >7.66 (P < 0.05), and 0.44 (P NS), respectively. In Mexican mestizo thrombophilic patients, the low prevalence of the factor V Leiden mutation (10.8%) and the high prevalence of the prothrombin 20210 mutation (13.5%) contrast with those identified in Caucasian thrombophilic patients (21% and 6%, respectively; P < 0.01). On the other hand, the high prevalence of the MTHFR 677 mutation gene both in normal controls (78%) and thrombophilic patients (61%) does not support a role of this mutation in the thrombogenesis of Mexican mestizo patients. PMID:11426488

Ruiz-Argüelles, G J; Garcés-Eisele, J; Reyes-Núñez, V; Ramírez-Cisneros, F J

2001-01-01

374

Ocular Involvement in Juvenile Idiopathic Arthritis: Classification and Treatment.  

PubMed

Juvenile idiopathic arthritis (JIA) is one of the most common rheumatic diseases in childhood with a prevalence of 4 in 1,000 children. Anterior uveitis is a well-known threatening comorbid condition of JIA and affects around 10 % of the patients depending on JIA subtype. A large proportion of children with JIA develop uveitis in the first year of disease and 73 to 90 % after 4 years. Uveitis can progress into adulthood and usually occurs as 'white uveitis', while in the JIA related to the enthesitis subtype that is symptomatic. Current studies reinforced the previous observations that early age of JIA onset, oligoarticular subtype and ANA reactivity are the main risk factors for the development of uveitis. Factors associated to worse prognosis are as follows: findings of 1+ or more vitreous cells at presentation and initial visual acuity of 20/200 or worse. The Standardization of Uveitis Nomenclature (SUN) Group took the first step to define outcome measures for uveitis, but it was established for adults. The Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC) proposed outcome measures for JIA-associated uveitis incorporating the SUN criteria in 2011. The current suggested management recommends to start early a steroid-sparing effective immunomodulatory systemic treatment. Methylprednisolone intravenous pulse therapy, rituximab, tocilizumab and abatacept are promising agents. Because JIA-associated uveitis is a potentially threatening comorbidity, it is important to recognize and treat it early to prevent any visual damage that could impair visual acuity. PMID:25081063

Foeldvari, Ivan

2014-08-01

375

Treat-to-target: a tailored treatment approach to rheumatoid arthritis.  

PubMed

In contrast to articles and books written about rheumatoid arthritis (RA) two or more decades ago that largely focused on 'coping' with the disease, there have been significant developments in the treatment of RA over the past 10 years. Patients can now be diagnosed and treated and expect to live functional lives, with less likelihood of experiencing the associated joint damage and disability. An important goal of RA therapy has shifted to initiate treatment early and aggressively, with frequent assessment and a target to achieve remission as quickly as possible. This 'treat-to-target' concept has been endorsed to maximise long-term health-related quality of life through control of symptoms, prevention of structural damage, normalisation of function and social participation. This article will look at therapies and strategies for the treatment of RA. It will also discuss a treatment algorithm for rheumatoid arthritis tailored to the individual patient's disease activity status. PMID:23901448

Palmer, Deborah; El Mledany, Yasser

376

[Caprine arthritis-encephalitis: trial of an adjuvant vaccine preparation. I. Clinical and virological study].  

PubMed

In purpose to protect goats against caprine arthritis encephalitis virus (CAEV), the first group of kids (I) was inoculated with purified, inactivated and adjuvant-treated virions, the second group (II) with adjuvant and the third one (III) with culture medium. 2-4 months later, the three groups were challenged with virulent CAEV by intraarticular route. On the clinical level, vaccinated and challenged kids show more early and severe arthritis than other groups. On the virological level, isolation of lentivirus from white blood cells and different organs is more important in group I than groups II and III. Therefore, vaccinations with inactivated and adjuvant-treated virions do not protect against a virulent challenge; there is an enhancement of lesions. We note that the adjuvant elicits a mild non-specific protection against virulent challenge. PMID:8391411

Russo, P; Vitu, C; Fontaine, J J; Vignoni, M

1993-04-01

377

Reconditioning in patients with rheumatoid arthritis  

Microsoft Academic Search

Rheumatologists traditionally have recommended to rheumatoid arthritis (RA) patients that they avoid dynamic and weight-bearing exercises because of concerns about aggravating joint inflammation and accelerating joint damage in such patients. These restrictions may lead to inade- quate levels of physical activity and deconditioning. Objective. - To review the literature on tolerance and benefits of conditioning training, including dynamic and weight-bearing

A. Mayoux Benhamou

2007-01-01

378

Switching rheumatoid arthritis treatments: An update  

Microsoft Academic Search

The first approved biological agents for the treatment of rheumatoid arthritis (RA) were tumour necrosis factor (TNF) antagonists, all of which improve disease signs and symptoms, and slow or prevent structural damage; however, they are not equally effective in all patients. About 30% of patients treated with a TNF agent fail to achieve an improvement of 20% in the American

Fabiola Atzeni; Piercarlo Sarzi-Puttini; Roberto Gorla; Antonio Marchesoni; Roberto Caporali

2011-01-01

379

A New Era in Rheumatoid Arthritis Treatment  

Microsoft Academic Search

Rheumatoid Arthritis (RA) is a systemic autoimmune disease that primarily manifests as a chronic symmetric polyarthritis. Treatment in the past was aimed at symp- tomatic pain relief. The initiation of disease modifying anti-rheumatic drugs (DMARDs) was historically started only after significant disease activity was pres- ent in order to reduce side effects from drug toxicities. Unfortunately, irreversible joint damage may

Jill C. Costello; Paul B. Halverson

2003-01-01

380

Management of melioidosis osteomyelitis and septic arthritis.  

PubMed

Little information is available about several important aspects of the treatment of melioidosis osteomyelitis and septic arthritis. We undertook a retrospective review of 50 patients with these conditions in an attempt to determine the effect of location of the disease, type of surgical intervention and duration of antibiotic treatment on outcome, particularly complications and relapse. We found that there was a 27.5% risk of osteomyelitis of the adjacent bone in patients with septic arthritis in the lower limb. Patients with septic arthritis and osteomyelitis of an adjacent bone were in hospital significantly longer (p = 0.001), needed more operations (p = 0.031) and had a significantly higher rate of complications and re-presentation (p = 0.048). More than half the patients (61%), most particularly those with multifocal bone and joint involvement, and those with septic arthritis and osteomyelitis of an adjacent bone who were treated operatively, needed more visits to theatre. Cite this article: Bone Joint J 2015;97-B:277-82. PMID:25628295

Shetty, R P; Mathew, M; Smith, J; Morse, L P; Mehta, J A; Currie, B J

2015-02-01

381

Update on Treatment of Rheumatoid Arthritis  

PubMed Central

Treatment of rheumatoid arthritis consists of use of drugs, physical measures, social work interventions, education and reconstructive surgery. The physician plays a co-ordinating role, since most patients with significant rheumatoid arthritis will require treatment by more than one member of the health-care team. Our drug armamentarium, including anti-inflammatory agents, disease suppressants, analgesics, rarely steroids, and even more rarely immunosuppressants, can be used to good effect in suppressing the synovitis of rheumatoid arthritis and in relieving pain. Physiotherapy, occupational therapy, nursing and social work interventions will help the patient to maintain function and to maintain their optimal level of fitness, including exercise tolerance, joint range, muscle strength and psycho-social function. Coping abilities can be greatly enhanced by a positive approach from the physician, and this, together with the very real benefits of the foregoing treatments, can produce a highly rewarding result for physician and patient alike, in terms of improved quality of life for the rheumatoid arthritis patient. PMID:21263856

Patterson, A. Caroline

1987-01-01

382

Hard Metal Alveolitis Accompanied by Rheumatoid Arthritis  

Microsoft Academic Search

Hard metal lung diseases (HML) are rare, and complex to diagnose. We describe the case of a patient with allergic alveolitis accompanied by rheumatoid arthritis. A sharpener of hard metal by trade, our patient was a 45-year-old, nonsmoking Caucasian female who experienced symptoms of cough and phlegm, and dyspnea on exertion. Preliminary lung findings were inspiratory rales in both basal

Paula A. Hahtola; Ritva E. Järvenpää; Kari Lounatmaa; Jorma J. Mattila; Immo Rantala; Jukka A. Uitti; Seppo Sutinen

2000-01-01

383

The cervical spine in juvenile chronic arthritis  

Microsoft Academic Search

Background context: In patients with juvenile chronic arthritis (JCA) the cervical spine is often affected, leading to pain and functional limitations.Purpose: To describe the frequency of the radiographic abnormalities in the cervical spine of a large series of patients with JCA, examined after skeletal maturity.Study design: Consecutive patients with JCA, who had cervical spine radiographs available taken at adult age

Kari Laiho; Anneli Savolainen; Hannu Kautiainen; Pertti Kekki; Markku Kauppi

2002-01-01

384

Leflunomide or Methotrexate for Juvenile Rheumatoid Arthritis  

Microsoft Academic Search

In patients with polyarticular juvenile rheumatoid arthritis, methotrexate and lefluno- mide both resulted in high rates of clinical improvement, but the rate was slightly greater for methotrexate. At the doses used in this study, methotrexate was more effective than leflunomide. abstract

Earl Silverman; Richard Mouy; Lynn Spiegel; Lawrence K. Jung; Rotraud K. Saurenmann; Pekka Lahdenne; Gerd Horneff; Immaculada Calvo; Ilona S. Szer; Karen Simpson; John A. Stewart; Vibeke Strand; Bridgewater Sanofi-Aventis; Sanofi-Aventis Pharma Cana

2010-01-01

385

Mud pack therapy in rheumatoid arthritis  

Microsoft Academic Search

Summary Twenty-eight patients with classical or definite rheumatoid arthritis were randomly divided into two groups of fourteen patients each. All patients were treated once a day with mud packs derived from the Dead Sea heated to 40°C and applied over the four extremities, neck and back for 20 minutes. Group 1 was treated with the true mud packs and Group

S. Sukenik; D. Buskila; L. Neumann; A. Kleiner-Baumgarten

1992-01-01

386

The Impact of Arthritis on Canadian Women  

Microsoft Academic Search

HEALTH ISSUE: Arthritis is one of the most prevalent chronic conditions in Canada and a leading cause of long-term disability, pain, and increased health care utilization. It is also a far more prevalent condition among women than men. Information was obtained primarily from the 1998–99 National Population Health Survey and the Canadian Joint Replacement Registry. KEY FINDINGS: In 1998, the

Elizabeth M Badley; Naomi M Kasman

2004-01-01

387

ICF Core Sets for rheumatoid arthritis  

Microsoft Academic Search

Objective: To report on the results of the consensus process integrating evidence from preliminary studies to develop the first version of a Comprehensive ICF Core Set and a Brief ICF Core Set for rheumatoid arthritis. Methods: A formal decision-making and consensus process integrating evidence gathered from preliminary studies was followed. Preliminary studies included a Delphi exercise, a systematic review, and

Gerold Stucki; Alarcos Cieza; Szilvia Geyh; Linamara Battistella; Jill Lloyd; Deborah Symmons; Nenad Kostanjsek; Jan Schouten

2004-01-01

388

Temporomandibular arthritis in familial Mediterranean fever.  

PubMed

Temporomandibular joint arthritis is a rare manifestation of familial Mediterranean fever and should be considered in patients of Mediterranean origin. Recently we treated four patients suffering from this condition, and intra-articular corticosteroid injection resulted in rapid resolution of the pain and disability in two. Computed tomography confirmed the usefulness of this therapeutic modality. PMID:1468924

Tovi, F; Gatot, A; Fliss, D

1992-01-01

389

Emerging MRI methods in rheumatoid arthritis  

Microsoft Academic Search

New MRI techniques have been developed to assess not only the static anatomy of synovial hyperplasia, bone changes and cartilage degradation in patients with rheumatoid arthritis (RA), but also the activity of the physiological events that cause these changes. This enables an estimation of the rate of change in the synovium, bone and cartilage as a result of disease activity

Camilo G. Borrero; James M. Mountz; John D. Mountz

2010-01-01

390

Internal Report CS Bioinformatics Track 14-05 August 2014 Leiden University  

E-print Network

Bioinformatics Track Genotypes-phenotype predictions in patients diagnosed with early onset Alzheimer Dimitra-phenotype predictions in patients diagnosed with early onset Alzheimer. Dimitra Zafeiropoulou Delft Bioinformatics Lab , Delft University of Technology, Delft, The Netherlands Defended on August 27th 2014 ABSTRACT Alzheimer

Emmerich, Michael

391

Early Childhood Presentation of Czech Dysplasia  

PubMed Central

Czech dysplasia, metatarsal type is an autosomal dominant skeletal disorder that is characterized by early-onset, progressive arthritis, brachydactyly of the 3rd and 4th toes, and characteristic radiographic findings in patients of normal stature. Patients with Czech dysplasia typically present in late childhood or later. In the present report, whole exome sequencing identified a mutation in COL2A1 (c.823C>T, p.R275C) known to be associated with Czech dysplasia in a 3.5 year old female who had a family history of early-onset arthritis and who was asymptomatic except for prominent knees. The use of whole exome sequencing facilitated diagnosis of this rare disease (less than 15 families in the literature) in the presymptomatic period and thus enabled us to provide early anticipatory guidance and genetic counseling for the family. PMID:23448908

Burrage, Lindsay C.; Lu, James T.; Liu, David S.; Moss, Timothy J.; Gibbs, Richard; Schlesinger, Alan E.; Bacino, Carlos A.; Campeau, Philippe M.; Lee, Brendan H.

2013-01-01

392

Serum melatonin in juvenile rheumatoid arthritis: correlation with disease activity.  

PubMed

The study was conducted to investigate the abnormalities in early morning serum melatonin among patients with Juvenile Rheumatoid Arthritis (JRA) and to outline its relation to disease activity and severity. Twenty one patients with JRA and twenty healthy age and sex matched controls were enrolled in the study. Fifteen patients had polyarticular JRA, 3 had oligoarticular and 3 had systemic onset JRA. Evaluation was carried out clinically, functionally and radiologically by using disease activity score, Juvenile Arthritis Functional Assessment Report for Children (JAFAR-C score) and modified Larsen score, respectively. Laboratory investigations included Complete Blood Picture (CBC), The Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), classic IgM Rheumatoid Factor (RF), Anti-nuclear Antibodies (ANA) and melatonin estimation in serum. The serum levels of melatonin were significantly increased in JRA patients (mean +/- SD = 13.9 +/- 8 pg mL(-1)) as compared to healthy controls (mean +/- SD = 8.1 +/- 2.7 pg mL(-1), p < 0.01). A significant positive correlation could link serum melatonin levels to disease activity scores and ESR (r = 0.91, p < 0.001 and r = 0.55, p < 0.01, respectively). No significant correlation was found between melatonin and either Larsen or JAFAR scores (r = 0.19, r = 0.15, respectively). According to melatonin levels, there were 2 groups of patients: Group I with elevated melatonin level (more than 11 pg mL(-1)) (n = 15) and group II with normal melatonin level (less than 11 pg mL(-1)) (n = 6). Patients with elevated melatonin levels had higher ESR (p < 0.05), higher disease activity scores (p < 0.01) and Larsen scores (p < 0.05), than the group of patients with normal serum melatonin. The results of GAFAR scores were comparable between the two groups (p > 0.05). Hence the study conclude that the elevated melatonin levels among JRA patients with active synovitis and its close relation to disease activity rather than disease severity suggests that melatonin might play a promoting role in rheumatoid arthritis. Hence, inhibition of its synthesis and/or action by specific antagonists may be of therapeutic value. PMID:19069959

El-Awady, Hanaa Mahmoud; El-Wakkad, Amany Salah El-Dien; Saleh, Maysa Tawheed; Muhammad, Saadia Ibraheem; Ghaniema, Eiman Mahmoud

2007-05-01

393

Tumor necrosis factor ?-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis  

PubMed Central

Introduction Tumor necrosis factor-alpha (TNF?) plays a pivotal role in rheumatoid arthritis (RA); however, the mechanism of action of TNF? antagonists in RA is poorly defined. Immunization of DBA/1 mice with glucose-6-phosphate isomerase (GPI) induces severe acute arthritis. This arthritis can be controlled by TNF? antagonists, suggesting similar etiology to RA. In this study, we explored TNF?-related mechanisms of arthritis. Methods First, we performed GeneChip analysis using splenocytes of mice with GPI-induced arthritis. Expression of TNF?-induced adipose-related protein (TIARP) mRNA and protein in spleens, joints and lymph nodes was evaluated, and fluctuation of TIARP mRNA was analyzed after administration of anti-TNF? monoclonal antibody (mAb). Localization of TIARP in spleen and joints was also explored. Six-transmembrane epithelial antigen of the prostate (STEAP) families of proteins, the human ortholog of TIARP gene, were also evaluated in human peripheral blood mononucleocytes and synovium. Results Among the arrayed TNF?-related genes, the expression of TIARP mRNA was the highest (more than 20 times the control). TIARP mRNA was detected specifically in joints and spleens of arthritic mice, and their levels in the synovia correlated with severity of joint swelling. Treatment with anti-TNF mAb significantly reduced TIARP mRNA expression in splenocytes. Among the splenocytes, CD11b+ cells were the main source of TIARP mRNA. Immunohistochemistry showed that TIARP protein was mainly localized in hyperplastic synovium. Among the STEAP family of proteins, STEAP4 was highly upregulated in joints of patients with RA and especially co-localized with CD68+ macrophages. Conclusions The results shed light on the new mechanism of action of TNF? antagonists in autoimmune arthritis, suggesting that TIARP plays an important role in inflammatory arthritis, through the regulation of inflammatory cytokines. PMID:19660107

Inoue, Asuka; Matsumoto, Isao; Tanaka, Yoko; Iwanami, Keiichi; Kanamori, Akihiro; Ochiai, Naoyuki; Goto, Daisuke; Ito, Satoshi; Sumida, Takayuki

2009-01-01

394

Hand bone mass in rheumatoid arthritis: A review of the literature  

PubMed Central

Rheumatoid arthritis (RA) is a common chronic inflammatory disease and periarticular osteoporosis or osteopenia of the inflamed hand joints is an early feature of RA. Quantitative measurement of hand bone loss may be an outcome measure for the detection of joint destruction and disease progression in early RA. This systematic review examines the published literature reporting hand bone mass in patients with RA, particularly those using the dual X-ray absorptiometry (DXA) methods. The majority of the studies reported that hand bone loss is associated with disease activity, functional status and radiological progression in early RA. Quantitative measurement of hand bone mineral density by DXA may be a useful and practical outcome measure in RA and may be predictive for radiographic progression or functional status in patients with early RA.

Kilic, Gamze; Ozgocmen, Salih

2015-01-01

395

78 FR 32667 - Draft Guidance for Industry on Rheumatoid Arthritis: Developing Drug Products for Treatment...  

Federal Register 2010, 2011, 2012, 2013

...Industry on Rheumatoid Arthritis: Developing Drug Products for Treatment; Availability...products for the treatment of patients with rheumatoid arthritis (RA). It...Products for the Treatment of Rheumatoid Arthritis...

2013-05-31

396

76 FR 61722 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel, Career...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2011-10-05

397

76 FR 77544 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting Pursuant to...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. The meeting...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. Date:...

2011-12-13

398

78 FR 18357 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; NIAMS...Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, 6701 Democracy...

2013-03-26

399

77 FR 32651 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; Program...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2012-06-01

400

77 FR 12605 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Initial Review Group, Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Review...

2012-03-01

401

78 FR 13364 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; NIAMS...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2013-02-27

402

75 FR 28260 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting Pursuant to...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. The meeting...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. Date:...

2010-05-20

403

77 FR 59937 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; NIAMS...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2012-10-01

404

77 FR 38847 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases, Special Emphasis Panel, Small...Institute of Arthritis,Musculoskeletal and Skin Diseases, National Institutes of...

2012-06-29

405

75 FR 48979 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting Pursuant to...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. The meeting...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. Date:...

2010-08-12

406

77 FR 28397 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel, P30 Rheumatic...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2012-05-14

407

77 FR 39714 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases, Special Emphasis Panel, Clinical...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2012-07-05

408

77 FR 4051 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases, Special Emphasis Panel, Osteoarthritis...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2012-01-26

409

78 FR 58320 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Initial Review Group; Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Review...

2013-09-23

410

76 FR 13649 - National Institute of Arthritis and Musculoskeletal And Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal And Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; Program...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2011-03-14

411

76 FR 35225 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases, Special Emphasis Panel. Clinical...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2011-06-16

412

78 FR 40486 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Conflict...

2013-07-05

413

78 FR 7790 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Initial Review Group; Arthritis and Musculoskeletal and Skin Diseases Special Grants Review...

2013-02-04

414

75 FR 6676 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee...846, Arthritis, Musculoskeletal and Skin Diseases Research, National...

2010-02-10

415

78 FR 29144 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; Ancillary...Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, 6701 Democracy...

2013-05-17

416

76 FR 24892 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases, Special Emphasis Panel, Clinical...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2011-05-03

417

76 FR 40385 - National Institute of Arthritis and Musculoskeletal and Skin Diseases Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases, Special Emphasis Panel, Ancillary...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2011-07-08

418

77 FR 61011 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Initial Review Group; Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Review...

2012-10-05

419

77 FR 9671 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; Career...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2012-02-17

420

76 FR 24896 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting Pursuant to...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. The meeting...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. Date:...

2011-05-03

421

76 FR 28440 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Initial Review Group, Arthritis and Musculoskeletal and Skin Diseases Special Grants Review...

2011-05-17

422

76 FR 6806 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; Ancillary...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2011-02-08

423

75 FR 6046 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel, Ancillary...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel,...

2010-02-05

424

76 FR 51044 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting Pursuant to...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. The meeting...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. Date:...

2011-08-17

425

75 FR 29770 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; Career...846, Arthritis, Musculoskeletal and Skin Diseases Research, National...

2010-05-27

426

78 FR 9933 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; Ancillary...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2013-02-12

427

76 FR 55399 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Initial Review Group, Arthritis and Musculoskeletal and Skin Diseases Special Grants Review...

2011-09-07

428

78 FR 8549 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Initial Review Group; Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Review...

2013-02-06

429

78 FR 32261 - National Institute of Arthritis And Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis And Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Initial Review Group, Arthritis and Musculoskeletal and Skin Diseases Special Grants Review...

2013-05-29

430

77 FR 16246 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases, including consideration of personnel...Institute of Arthritis & Musculoskeletal and Skin Diseases, Building 10, Room 9N228,...

2012-03-20

431

75 FR 1792 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel, Small...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2010-01-13

432

75 FR 14173 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; Small...Institute of Arthritis, Musculoskeletal and Skin Diseases, 6701 Democracy Blvd,...

2010-03-24

433

78 FR 36789 - National Institute of Arthritis And Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis And Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; NIAMS...Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, 6701 Democracy...

2013-06-19

434

75 FR 54897 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; Muscle...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel;...

2010-09-09

435

78 FR 17679 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Closed Meeting Pursuant to section...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; NIAMS...Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, 6701 Democracy...

2013-03-22

436

75 FR 27352 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee...Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of...

2010-05-14

437

77 FR 63844 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; NIAMS...Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of...

2012-10-17

438

78 FR 59945 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; NIAMS...Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, 6701 Democracy...

2013-09-30

439

78 FR 38065 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Initial Review Group; Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Review...

2013-06-25

440

77 FR 4048 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Initial Review Group, Arthritis and Musculoskeletal and Skin Diseases Special Grants Review...

2012-01-26

441

78 FR 64223 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel, NIAMS...Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, 6701 Democracy...

2013-10-28

442

76 FR 6807 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2011-02-08

443

78 FR 25753 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting Pursuant to...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. The meeting...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. Date:...

2013-05-02

444

77 FR 47653 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting Pursuant to...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. The meeting...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. Date:...

2012-08-09

445

75 FR 34752 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel, Program...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel,...

2010-06-18

446

75 FR 26762 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel, Ancillary...Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of...

2010-05-12

447

75 FR 67989 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel. Centers...846, Arthritis, Musculoskeletal and Skin Diseases Research, National...

2010-11-04

448

77 FR 26301 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting Pursuant to...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. The meeting...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. Date:...

2012-05-03

449

77 FR 20646 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel, Program...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2012-04-05

450

78 FR 47327 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting Pursuant to...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. The meeting...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. Date:...

2013-08-05

451

76 FR 1187 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting Pursuant to...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. The meeting...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. Date:...

2011-01-07

452

76 FR 31968 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; Ancillary...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2011-06-02

453

78 FR 21617 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel, NIAMS...Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, 6701 Democracy...

2013-04-11

454

75 FR 63496 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee...846, Arthritis, Musculoskeletal and Skin Diseases Research, National...

2010-10-15

455

77 FR 60447 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Initial Review Group; Arthritis and Musculoskeletal and Skin Diseases Special Grants Review...

2012-10-03

456

77 FR 75181 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Meeting Pursuant to...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. The meeting...National Arthritis and Musculoskeletal and Skin Diseases Advisory Council. Date:...

2012-12-19

457

77 FR 66853 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; Multidisciplinary...846, Arthritis, Musculoskeletal and Skin Diseases Research, National...

2012-11-07

458

78 FR 66021 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; Mentored...Institutes of Arthritis and Musculoskeletal and Skin Diseases, NIH, 6701 Democracy...

2013-11-04

459

77 FR 35416 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases, Special Emphasis Panel; Program...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2012-06-13

460

77 FR 27470 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Initial Review Group;Arthritis and Musculoskeletal and Skin Diseases Special Grants Review...

2012-05-10

461

75 FR 63492 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel, Career...Institute of Arthritis, Musculoskeletal and Skin Diseases, 6701 Democracy Blvd.,...

2010-10-15

462

76 FR 14035 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; Career...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2011-03-15

463

76 FR 55399 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases, Special Emphasis Panel, Small...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2011-09-07

464

78 FR 20118 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases, including consideration of personnel...Institute of Arthritis & Musculoskeletal and Skin Diseases, Building 10, Room 9N228,...

2013-04-03

465

77 FR 18253 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel; Clinical...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2012-03-27

466

78 FR 64509 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Initial Review Group; Arthritis and Musculoskeletal and Skin Diseases Special Grants Review...

2013-10-29

467

77 FR 35988 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant...Committee: Arthritis and Musculoskeletal and Skin Diseases Initial Review Group; Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Review...

2012-06-15

468

75 FR 70679 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings Pursuant...Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel, Clinical...Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of...

2010-11-18

469

Rheumatoid Arthritis When Your Immune System Attacks Your Body | NIH MedlinePlus the Magazine  

MedlinePLUS

... Understanding Rheumatoid Arthritis (RA) Rheumatoid Arthritis When Your Immune System Attacks Your Body Past Issues / Summer 2014 Table ... disease, which means the arthritis results from your immune system attacking your body's own tissues. The course of ...

470

Management of rheumatoid arthritis: consensus recommendations from the Hong Kong Society of Rheumatology.  

PubMed

Given the recent availability of novel biologic agents for the treatment of rheumatoid arthritis (RA), the Hong Kong Society of Rheumatology has developed consensus recommendations on the management of RA, which aim at providing guidance to local physicians on appropriate, literature-based management of this condition, specifically on the indications and monitoring of the biologic disease-modifying anti-rheumatic drugs (DMARDs). The recommendations were developed using the European League Against Rheumatism (EULAR) recommendations for the management of early arthritis as a guide, along with local expert opinion. As significant joint damage occurs early in the course of RA, initiating therapy early is key to minimizing further damage and disability. Patients with serious disease or poor prognosis should receive early, aggressive therapy. Because of its good efficacy and safety profile, methotrexate is considered the standard first-line DMARD for most treatment-naïve RA patients. Patients with a suboptimal response to methotrexate monotherapy should receive step-up (combination) therapy with either the synthetic or biologic DMARDs. In recent years, combinations of methotrexate with tocilizumab, abatacept, or rituximab have emerged as effective therapies in patients who are unresponsive to traditional DMARDs or the anti-tumor necrosis factor (TNF)-? agents. As biologic agents can increase the risk of infections such as tuberculosis and reactivation of viral hepatitis, screening for the presence of latent tuberculosis and chronic viral hepatitis carrier state is recommended before initiating therapy. PMID:21046421

Mok, Chi Chiu; Tam, Lai Shan; Chan, Tak Hin; Lee, Gavin K W; Li, Edmund K M

2011-03-01

471

Davignon et al. Arthritis Research & Therapy 2010, 12:R142 http://arthritis-research.com/content/12/4/R142  

E-print Network

Davignon et al. Arthritis Research & Therapy 2010, 12:R142 http://arthritis-research.com/content/12-cell response in rheumatoid arthritis patients receiving anti-tumor necrosis factor treatments Jean-Luc Davignon the treatment of rheumatoid arthritis (RA). However, serious infections are a major concern in patients

Paris-Sud XI, Université de

472

Heparan sulfate differences in rheumatoid arthritis versus healthy sera.  

PubMed

Heparan sulfate (HS) is a complex and highly variable polysaccharide, expressed ubiquitously on the cell surface as HS proteoglycans (HSPGs), and found in the extracellular matrix as free HS fragments. Its heterogeneity due to various acetylation and sulfation patterns endows a multitude of functions. In animal tissues, HS interacts with a wide range of proteins to mediate numerous biological activities; given its multiple roles in inflammation processes, characterization of HS in human serum has significant potential for elucidating disease mechanisms. Historically, investigation of HS was limited by its low concentration in human serum, together with the complexity of the serum matrix. In this study, we used a modified mass spectrometry method to examine HS disaccharide profiles in the serum of 50 women with rheumatoid arthritis (RA), and compared our results to 51 sera from healthy women. Using various purification methods and online LC-MS/MS, we discovered statistically significant differences in the sulfation and acetylation patterns between populations. Since early diagnosis of RA is considered important in decelerating the disease's progression, identification of specific biomolecule characterizations may provide crucial information towards developing new therapies for suppressing the disease in its early stages. This is the first report of potential glycosaminoglycan biomarkers for RA found in human sera, while acknowledging the obvious fact that a larger population set, and more stringent collection parameters, will need to be investigated in the future. PMID:25217862

Sabol, Jenny K; Wei, Wei; López-Hoyos, Marcos; Seo, Youjin; Andaya, Armann; Leary, Julie A

2014-11-01

473

Psychological approaches to the management of arthritis pain  

Microsoft Academic Search

The present review examines the literature regarding the efficacy of cognitive-behavioral and other self-control interventions in helping arthritis patients reduce their pain and functional disabilities. The evidence indicates that self-control interventions have produced significant and positive changes in the pain and functional disabilities of patients with rheumatoid arthritis and arthritis secondary to hemophilia. However, the literature suffers from deficiencies with

Laurence A. Bradley; Larry D. Young; Karen O. Anderson; Lisa K. McDaniel; Robert A. Turner; Carlos A. Agudelo

1984-01-01

474

Immunosuppression by fractionated total lymphoid irradiation in collagen arthritis  

SciTech Connect

Treatments with fractionated total lymphoid irradiation (TLI) and cyclophosphamide were evaluated for rats injected with type II collagen. Preadministration of TLI and repeated injections of cyclophosphamide suppressed the severity of arthritis and lowered antibody titers to collagen significantly. TLI initiated at the onset of collagen arthritis decreased humoral and cellular responses to collagen but did not affect the severity of arthritis. These data demonstrate that both TLi and cyclophosphamide are immunosuppressive in an experimentally inducible autoimmune disease.

McCune, W.J.; Buckley, J.A.; Belli, J.A.; Trentham, D.E.

1982-05-01

475

[Unusual presentation of juvenile idiopathic arthritis and autoimmune hepatitis].  

PubMed

The coexistence of autoimmune hepatitis and juvenile idiopathic arthritis is very rare. This is the case of an 18 month old female patient whose first sign of disease was torticollis due to an underlying atlanto-axial subluxation. Three months later, bilateral knee arthritis developed and she was diagnosed with Juvenile Idiopathic Arthritis. Throughout the disease a persistent elevation of liver enzymes was noted, combined with positive antinuclear antibodies and hypergammaglobulinemia, reaching the diagnosis of concomitant autoimmune hepatitis. PMID:25066796

Moreno Prieto, M; Carbonero Celis, M J; Cuadrado Caballero, M C

2015-01-01

476

Arthritis Critically Dependent on Innate Immune System Players  

Microsoft Academic Search

K\\/BxN T cell receptor transgenic mice are a model of inflammatory arthritis, similar to rheumatoid arthritis. Disease in these animals is focused specifically on the joints but stems from autoreactivity to a ubiquitously expressed antigen, glucose-6-phosphate isomerase (GPI). T and B cells are both required for disease initiation, but anti-GPI immunoglobulins (Igs), alone, can induce arthritis in lymphocyte-deficient recipients. Here,

Hong Ji; Koichiro Ohmura; Umar Mahmood; David M Lee; Frans M. A Hofhuis; Susan A Boackle; Kazue Takahashi; V. Michael Holers; Mark Walport; Craig Gerard; Alan Ezekowitz; Michael C Carroll; Michael Brenner; Ralph Weissleder; J. Sjef Verbeek; Veronique Duchatelle; Claude Degott; Christophe Benoist; Diane Mathis

2002-01-01

477

Intra-articular vs. systemic administration of etanercept in antigen-induced arthritis in the temporomandibular joint. Part II: mandibular growth  

Microsoft Academic Search

BACKGROUND: Temporomandibular joint (TMJ) arthritis in children causes alterations in the craniomandibular growth. Resultant abnormalities include; condylar erosions, a posterior mandibular rotation pattern, micrognathia, malocclusion with an anterior open bite, altered joint and muscular function occasionally associated with pain. These alterations may be prevented by early aggressive anti-inflammatory intervention. Previously, we have shown that intra-articular (IA) corticosteroid reduces TMJ inflammation

Peter Stoustrup; Kasper D Kristensen; Annelise Küseler; Thomas K Pedersen; John Gelineck; Troels Herlin

2009-01-01

478

Prediction of efficacy of anti-TNF biologic agent, infliximab, for rheumatoid arthritis patients using a comprehensive transcriptome analysis of white blood cells  

Microsoft Academic Search

Introduction of biologics, such as infliximab, to the therapy of rheumatoid arthritis (RA) patients has revolutionized the treatment of this disease. However, biomarkers for predicting the efficacy of the drug at an early phase of treatment for selecting real responders have not been found. We here present predictive markers based on a thorough transcriptome analysis of white blood cells from

Motohiko Tanino; Ryo Matoba; Seiji Nakamura; Hideto Kameda; Kouichi Amano; Toshitsugu Okayama; Hayato Nagasawa; Katsuya Suzuki; Kenichi Matsubara; Tsutomu Takeuchi

2009-01-01

479

Early Algebra, Early Arithmetic  

NSDL National Science Digital Library

This site offers a variety of early algebra resources for teachers in grades 1-6, parents, researchers, policy makers, administrators, and curriculum developers. Site includes early algebra activities, handouts and overheads in PDF format (requires Acrobat Reader), articles, short reviews of articles and books focusing on early math and early algebra, news and events, and more. A valuable source for pre algebra activities in the elementary classroom.

National Science Foundation (NSF)

2007-12-12

480

Rheumatoid Arthritis and Salivary Biomarkers of Periodontal Disease  

PubMed Central

Aim To test the hypothesis that rheumatoid arthritis influenced levels of salivary biomarkers of periodontal disease. Methods Medical assessments, periodontal examinations, and pain ratings were obtained from 35 rheumatoid arthritis, 35 chronic periodontitis and 35 age and gender-matched healthy controls in a cross-sectional, case-controlled study. Unstimulated whole saliva samples were analyzed for interleukin-1? (IL-1?), matrix-metalloproteinase-8 (MMP-8) and tumor necrosis factor-? (TNF)-? concentrations. Results The arthritis and healthy groups had significantly less oral disease than the periodontitis group (p<0.0001), with the arthritis group having significantly more sites bleeding on probing (BOP) than matched controls (p=0.012). Salivary levels of MMP-8 and IL-1? were significantly elevated in the periodontal disease group (p?0.002), and IL-1? was the only biomarker with significantly higher levels in the arthritis group compared with controls (p=0.002). Arthritis patients receiving anti-TNF-? antibody therapy had significantly lower IL-1? and TNF-? levels compared with arthritis patients not on anti-TNF-? therapy (p=0.016, p=0.024) and healthy controls (p<0.001, p=0.011), respectively. Conclusion Rheumatoid arthritis patients have higher levels of periodontal inflammation than healthy controls, ie. increased BOP. Systemic inflammation appears to influence levels of select salivary biomarkers of periodontal disease, and anti-TNF-? antibody-based disease modifying therapy significantly lowers salivary IL-1? and TNF-? levels in rheumatoid arthritis. PMID:20880053

Mirrielees, Jeffrey; Crofford, Leslie J.; Lin, Yushun; Kryscio, Richard J.; Dawson, Dolphus R.; Ebersole, Jeffrey L.; Miller, Craig S.

2010-01-01

481

Effect and Treatment of Chronic Pain in Inflammatory Arthritis  

PubMed Central

Pain is the most common reason patients with inflammatory arthritis see a rheumatologist. Patients consistently rate pain as one of their highest priorities, and pain is the single most important determinant of patient global assessment of disease activity. Although pain is commonly interpreted as a marker of inflammation, the correlation between pain intensity and measures of peripheral inflammation is imperfect. The prevalence of chronic, non-inflammatory pain syndromes such as fibromyalgia is higher among patients with inflammatory arthritis than in the general population. Inflammatory arthritis patients with fibromyalgia have higher measures of disease activity and lower quality of life than inflammatory patients who do not have fibromyalgia. This review article focuses on current literature involving the effects of pain on disease assessment and quality of life for patients with inflammatory arthritis. It also reviews non-pharmacologic and pharmacologic options for treatment of pain for patients with inflammatory arthritis, focusing on the implications of comorbidities and concurrent disease-modifying antirheumatic drug therapy. Although several studies have examined the effects of reducing inflammation for patients with inflammatory arthritis, very few clinical trials have examined the safety and efficacy of treatment directed specifically towards pain pathways. Most studies have been small, have focused on rheumatoid arthritis or mixed populations (e.g., rheumatoid arthritis plus osteoarthritis), and have been at high risk of bias. Larger, longitudinal studies are needed to examine the mechanisms of pain in inflammatory arthritis and to determine the safety and efficacy of analgesic medications in this specific patient population. PMID:23292816

2013-01-01

482

[Total ankle arthroplasty for rheumatoid arthritis].  

PubMed

Modern second generation total ankle arthroplasty is now a serious alternative to ankle fusion in patients with rheumatoid arthritis after careful assessment of the indications. The midterm results with 10-year survival rates between 70% and 90% and the possible revision for implant exchange or arthrodesis are the reasons for the increasing importance of ankle arthroplasty. Patients with rheumatoid arthritis in particular with generally lower physical requirements can expect a pain-free function of the operated ankle for 8-10 years. In comparison to fusion ankle arthroplasty allows a significantly faster remobilization and reserves the correction capabilities of the ankle. Arthrodesis remains a valuable therapeutic alternative for severe bony destruction and instability as well as a possible fallback for failure of arthroplasty. PMID:21691912

Schill, S; Wetzel, R

2011-07-01

483

Induction of lyme arthritis in LSH hamsters.  

PubMed Central

In studies of experimental Lyme disease, a major obstacle has been the unavailability of a suitable animal model. We found that irradiated LSH/Ss Lak hamsters developed arthritis after injection of Borrelia burgdorferi in the hind paws. When nonirradiated hamsters were injected in the hind paws with B. burgdorferi, acute transient synovitis was present. A diffuse neutrophilic infiltrate involved the synovia and periarticular structures. The inflammation was associated with edema, hyperemia, and granulation tissue. Numerous spirochetes were seen in the synovial and subsynovial tissues. The histopathologic changes were enhanced in irradiated hamsters. The onset and duration of the induced swelling were dependent on the dose of radiation and the inoculum of spirochetes. Inoculation of irradiated hamsters with Formalin-killed spirochetes or medium in which B. burgdorferi had grown for 7 days failed to induce swelling. This animal model should prove useful for studies of the immune response to B. burgdorferi and the pathogenesis of Lyme arthritis. Images PMID:3410540

Schmitz, J L; Schell, R F; Hejka, A; England, D M; Konick, L

1988-01-01

484

Naproxen in rheumatoid arthritis. Extended trial.  

PubMed Central

121 patients with active rheumatoid arthritis, 91 of whom had proved intolerant of other nonsteroidal anti-inflammatory agents, were treated for a mean of 10 months with naproxen. A dosage of 250 mg twice daily produced sustained improvement in most of the standard clinical measurements. 28 patients complained of side effects, with a lower than expected incidence of gastrointestinal complaints and no drug-induced rash being recorded. 19 patients withdrew from the trial because of side effects, while a further 22 withdrew because the drug was ineffective. Naproxen is a useful drug for long-term use in patients with rheumatoid arthritis, including those who have proved intolerant of or experienced inadequate symptomatic relief from other nonsteriodal anti-inflammatory agents. PMID:795386

Mowat, A G; Ansell, B M; Gumpel, J M; Hill, H F; Hill, A G; Stoppard, M

1976-01-01

485

Abatacept in the treatment of rheumatoid arthritis  

PubMed Central

T-cell biology has regained importance in the pathogenesis of rheumatoid arthritis. Despite the significant improvements associated with the introduction of tumor necrosis factor-? blockade, reasonable proportions of failures and suboptimal responses have been reported, necessitating a search for alternative targeted therapies. This has included drug therapy designed to interrupt T-cell activation via the co-stimulation pathway. Abatacept is a recombinant fusion protein that blocks the co-stimulatory signal mediated by the CD28-CD80/86 pathway, which is required for T-cell activation. Several clinical trials have confirmed the safety and efficacy of this drug in the treatment of rheumatoid arthritis. This review summarizes the clinical data supporting this line of treatment and considers the safety and efficacy data from phase II and III trials. PMID:19007425

Buch, Maya H; Vital, Edward M; Emery, Paul

2008-01-01

486

Induction of lyme arthritis in LSH hamsters  

SciTech Connect

In studies of experimental Lyme disease, a major obstacle has been the unavailability of a suitable animal model. We found that irradiated LSH/Ss Lak hamsters developed arthritis after injection of Borrelia burgdorferi in the hind paws. When nonirradiated hamsters were injected in the hind paws with B. burgdorferi, acute transient synovitis was present. A diffuse neutrophilic infiltrate involved the synovia and periarticular structures. The inflammation was associated with edema, hyperemia, and granulation tissue. Numerous spirochetes were seen in the synovial and subsynovial tissues. The histopathologic changes were enhanced in irradiated hamsters. The onset and duration of the induced swelling were dependent on the dose of radiation and the inoculum of spirochetes. Inoculation of irradiated hamsters with Formalin-killed spirochetes or medium in which B. burgdorferi had grown for 7 days failed to induce swelling. This animal model should prove useful for studies of the immune response to B. burgdorferi and the pathogenesis of Lyme arthritis.

Schmitz, J.L.; Schell, R.F.; Hejka, A.; England, D.M.; Konick, L.

1988-09-01

487

Anakinra for Myocarditis in Juvenile Idiopathic Arthritis  

PubMed Central

A 20-year-old pregnant woman with a history of juvenile idiopathic arthritis presented with flu-like symptoms, systemic inflammation with myocarditis, and severe cardiomyopathy. Six weeks earlier, her chronic-arthritis therapy had been changed from anakinra, an interleukin-1? receptor antagonist, to etanercept. When she resumed taking anakinra, her condition improved dramatically, including a complete recovery of ventricular function. Myocarditis is a well-recognized complication of systemic vasculitides. This unusual case emphasizes the important pathophysiologic role of interleukin receptors in the successful treatment of myocarditis. We suggest that clinical cardiologists be aware of the therapeutic usefulness of biological agents such as anakinra in patients with rheumatic conditions. PMID:24391342

Movva, Rajesh; Brown, Suzanne B.; Morris, D. Lynn; Figueredo, Vincent M.

2013-01-01

488

Differential Regulatory Role of Pituitary Adenylate Cyclase–Activating Polypeptide in the Serum-Transfer Arthritis Model  

PubMed Central

Objective Pituitary adenylate cyclase–activating polypeptide (PACAP) expressed in capsaicin-sensitive sensory neurons and immune cells has divergent functions in inflammatory and pain processes. This study was undertaken to investigate the involvement of PACAP in a mouse model of rheumatoid arthritis. Methods Arthritis was induced in PACAP?/? and wild-type (PACAP+/+) mice by K/BxN serum transfer. General features of the disease were investigated by semiquantitative scoring, plethysmometry, and histopathologic analysis. Mechano- and thermonociceptive thresholds and motor functions were also evaluated. Metabolic activity was assessed by positron emission tomography. Bone morphology was measured by in vivo micro–computed tomography, myeloperoxidase activity and superoxide production by bioluminescence imaging with luminol and lucigenin, respectively, and vascular permeability by fluorescent indocyanine green dye study. Results PACAP+/+ mice developed notable joint swelling, reduced grasping ability, and mechanical (but not thermal) hyperalgesia after K/BxN serum transfer. In PACAP?/? mice clinical scores and edema were significantly reduced, and mechanical hyperalgesia and motor impairment were absent, throughout the 2-week period of observation. Metabolic activity and superoxide production increased in the tibiotarsal joints of wild-type mice but were significantly lower in PACAP?/? animals. Myeloperoxidase activity in the ankle joints of PACAP?/? mice was significantly reduced in the early phase of arthritis, but increased in the late phase. Synovial hyperplasia was also significantly increased, and progressive bone spur formation was observed in PACAP-deficient mice only. Conclusion In PACAP-deficient mice with serum-transfer arthritis, joint swelling, vascular leakage, hyperalgesia, and early inflammatory cell accumulation are reduced; in the later phase of the disease, immune cell function and bone neoformation are increased. Elucidation of the underlying pathways of PACAP activity may open promising new avenues for development of therapy in inflammatory arthritis. PMID:25048575

Botz, Bálint; Bölcskei, Kata; Kereskai, László; Kovács, Miklós; Németh, Tamás; Szigeti, Krisztián; Horváth, Ildikó; Máthé, Domokos; Kovács, Noémi; Hashimoto, Hitoshi; Regl?di, Dóra; Szolcsányi, János; Pintér, Erika; Mócsai, Attila; Helyes, Zsuzsanna

2014-01-01

489

Heerlen polymorphism associated with type III protein S deficiency and factor V Leiden mutation in a Polish patient with deep vein thrombosis.  

PubMed

Protein S is one of the major natural anticoagulants. A missense serine 501 to proline (S501P) Heerlen polymorphism is associated with reduced levels of free protein S. Heerlen polymorphism, especially when combined with other thrombophilia risk factors, can lead to thromboembolic complications. To our knowledge, we report here the first Polish case associated with heterozygous Heerlen polymorphism resulting in type III protein S deficiency, detected in a 50-year-old man with several thrombotic episodes of deep and superficial veins and a highly positive thrombotic family history. The patient also had factor V Leiden mutation and persistently elevated anticardiolipin antibodies. It seems that increased risk of thrombotic complications could be explained in the patient by a synergy between the effects of Heerlen polymorphism, factor V Leiden heterozygous status and antiphospholipid syndrome. PMID:24365770

Wypasek, Ewa; Potaczek, Daniel P; Alhenc-Gelas, Martine; Undas, Anetta

2014-01-01

490

Patient access to rheumatoid arthritis treatments  

Microsoft Academic Search

This paper is an introduction to the study “The Burden of Rheumatoid Arthritis and Patient Access to Treatment”. The objective\\u000a of the study is to compare patient access to new drugs in Europe, North America and a selection of other countries, and to\\u000a analyse the determinants of differences between countries, as basis for a discussion on how patients’ access to

Bengt Jönsson

2008-01-01

491

Demodex folliculorum in patients with rheumatoid arthritis  

Microsoft Academic Search

The objective of this study was to investigate the incidence and density of Demodex folliculorum in the patients with rheumatoid arthritis (RA). Forty-one patients with RA and twenty-seven age and sex matched healthy controls\\u000a were enrolled in this study. Disease Activity Score (DAS 28) was used for the assessment of disease activity. Out of 41 patients,\\u000a 33 were females and

Ihsan H. Ciftci; Umit Dundar; Zafer Cetinkaya; Mustafa Kulac; Nilay Kiyildi; Aycan Turel; Deniz Evcik; Vural Kavuncu

2007-01-01

492

Kienbock's disease and juvenile idiopathic arthritis  

PubMed Central

Kienbock's disease or osteonecrosis of the lunate is an uncommon cause of wrist pain. . Though there have been several reports of cases in patients with various rheumatologic diseases, the precise etiology has currently not been established. We report a case of Kienbock's disease that occurred in a patient with juvenile idiopathic arthritis. To our knowledge, this is the first case report with an association between these two conditions. PMID:22363188

Desy, Nicholas M.; Bernstein, Mitchell; Harvey, Edward J.; Hazel, Hazel