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Sample records for levator anguli oris

  1. Anguli Parimana in Ayurveda and its association with adiposity and diabetes

    PubMed Central

    Shirodkar, Jyoti A.; Sayyad, Mehmood G.; Nanal, Vilas M.; Yajnik, Chittaranjan S.

    2014-01-01

    Background: Recent studies have shown the association of disproportionate body size measurements with noncommunicable diseases like diabetes. This concept is described in Ayurveda (1500 BC), which uses Anguli Parimana (the breadth of one's own finger as 1 unit) to measure the body proportions. Excessive tallness or shortness (deviation from the reference value of Anguli Parimana) indicated deranged meda dhaatu (mainly adipose tissue). Deranged meda dhatu was associated with Prameha (diabetes). Objectives: To find association of Anguli Parimana with modern parameters of adiposity and diabetes. Materials and Methods: We studied 192 village residents representing the whole population (94 men and 98 women) to measure height, arm span, facial structures and limbs and expressed them in Anguli pariman (ratio of each measure as: Length or height of the body part [cm]/anguli, i.e. average finger breadth [cm]). The Anguli measurements were associated with body mass index, body fat percentage by DEXA, glucose and fasting insulin levels. Results: The volunteers were adults between 20 and 40 years age. Their mean fasting and 2 h plasma glucose concentrations were 91.6 mg% and 102.8 mg%, respectively. Of all, only 6 subjects had impaired glucose tolerance, while 3 were diabetic (WHO 1999). When compared with reference Anguli measurements mentioned by Charaka Samhita and Sushruta Samhita, the participants had smaller height, facial structures, and lower limbs. Those, who had proportionately smaller facial, neck and limb structures, had higher obesity, adiposity, plasma glucose, insulin and insulin resistance (homeostatic model assessment [HOMA]-R) indicating higher metabolic risk. In contrast, those who had proportionately larger forehead and face had higher beta cell function measured as HOMA-B indicating lower risk for diabetes (r = 0.20 both P < 0.05 all, adjusted for age and gender). Conclusion: Compared with ancient Indian Anguli reference, our subjects were proportionately smaller in most of the measurements except fingers and upper arm. Relative smallness of body parts was predictive of increased risk of type 2 diabetes. PMID:25336850

  2. Scientific study of Charakokta Anguli Pramana in reference to human height.

    PubMed

    Muley, Shashikant K; Surve, Ajit A; Bhingare, Swati D

    2013-10-01

    Ayurveda has dynamic and creative view on health and gives importance to the individual while managing his health and also during treating the diseases. Ayurveda is a system of health science which not only includes the knowledge of body and diseases but also includes the way of living healthy i.e., "Swastha". The concept of Maana-Pramana is one of the significant contributions of Ayurveda. This study was undertaken to evaluate the Charakokta Sutra (verse) which implies that "Height (Aayama) of human being is 84 fingers (Anguli) and is equal to Arm Span (Vistaara)". In the present study, anthropometric measurements by finger were taken and exact site of particular finger in a manner to execute "Anguli Sthana Nishchiti" was determined. The data of Aayama and Vistaara of the 100 volunteers was recorded and statistically analysed. After comparing the Anguli Pramana (Measurement through finger) obtained at 78 different sites of both hands, it was established that measurement of Anguli Pramana at the site of medio-lateral proximal interphalangeal joint of middle finger of right and left hand, would be most accurate in estimating Anguli Pramana. PMID:24696571

  3. Levator Ani Muscle Anatomy Evaluated by Origin-Insertion Pairs

    PubMed Central

    Kearney, Rohna; Sawhney, Raja; DeLancey, John O. L.

    2005-01-01

    OBJECTIVE To examine the published literature and suggest a resolution to the confusion that exists in levator ani muscle descriptions and terminology. DATA SOURCES A MEDLINE search was performed using the keyword levator ani, limited to human studies in women. References found in these articles were reviewed to identify research reported before 1966 and articles not included in the search. STUDY SELECTION Studies were accepted if they contained direct observations of female specimens. Only those that contained specific descriptions or illustrations of the muscle origins and insertions in more than 5 female specimens were included. Review of 265 human studies yielded 9 qualifying articles, and reference tracing disclosed 3 additional reports. TABULATION, INTEGRATION, AND RESULTS The literature review identified 5 origin-insertion pairs consistently described in studies directly examining the levator ani muscle in women, but 16 terms were used by authors for these 5 components of the muscle. Labeled illustrations often provided more precise information than was provided in the text. Terms were reviewed for inconsistencies of usage and appropriateness of term choice. The terms puboperineal, pubovaginal, and puboanal (for components of the pubovisceral [pubococcygeal] muscle), along with puborectal and iliococcygeal, are sufficient to describe the divisions of the levator ani muscle. CONCLUSION Although there was great diversity and conflict in terms chosen among the original articles, the number of origin and insertion pairs was relatively consistent among authors and confusion can be avoided by standardizing terminology. PMID:15229017

  4. An anatomical study of the junction of the orbital septum and the levator aponeurosis in Orientals.

    PubMed

    Hwang, K; Kim, D J; Chung, R S; Lee, S I; Hiraga, Y

    1998-12-01

    The anatomical relationships of the orbital septum and levator aponeurosis has been studied in 40 eyelids subjected to blepharoplasty and corrective ptosis surgery by dissection in 10 cadavers and in histological sections. The orbital septum originates from the arcus marginalis of the frontal bone and consists of two layers. The whitish outer (superficial) layer, containing vertically running vessels, descends just inside the orbicularis oculi muscle to interdigitate with the levator aponeurosis with loose connective tissue, then disperses inferiorly. The inner (deep) layer follows the superficial one initially, then reflects at the levator aponeurosis and continues posteriorly with the levator sheath. We reconfirmed Whitnall's original description that the levator sheath thickens to form the superior transverse ligament runs continuously inferiorly anterior to the levator aponeurosis and forms the inner layer of the orbital septum. This detailed anatomical analysis should assist in performing upper eyelid surgery such as the Oriental double fold operation or levator resection. PMID:10209461

  5. Unusual origin of the levator scapulae muscle from mastoid process.

    PubMed

    Chotai, Pranit N; Loukas, Marios; Tubbs, R Shane

    2015-12-01

    Anatomic variations of the neck musculature are uncommon and incidentally found during cadaveric dissection. The levator scapulae muscle is found in the floor of the posterior cervical triangle. It connects the axial skeleton with the superior appendicular skeleton and acts as a scapular elevator. Normally, it originates from the transverse processes of first four cervical vertebrae and inserts into the superomedial border of the scapula. During a routine cadaveric dissection, we encountered an additional slip of the left levator scapulae originating from the left mastoid process. This muscle is frequently implicated in the etiopathology of neck and shoulder pain. Knowledge of this variation is not only interesting to anatomists, but also to surgeons operating on the posterior neck and physicians managing patients with cervical or shoulder pain. PMID:26074045

  6. Levator ani deformation during the second stage of labour.

    PubMed

    Berardi, Mario; Martinez-Romero, Oscar; Elías-Zúñiga, Alex; Rodríguez, Mauricio; Ceretti, Elisabetta; Fiorentino, Antonio; Donzella, Giorgio; Avanzini, Andrea

    2014-05-01

    A very important medical problem for females is urinary incontinence, sometimes associated with faecal incontinence and pelvic organ prolapse. One of the most common reasons these issues are increasing is clearly the muscle damage during childbirth. This article focusses on understanding the complex behaviour of the levator ani muscles involved in the second stage of labour. A geometrical model obtained from a 23-year-old nulliparous woman was used to simulate childbirth. Several assumptions were introduced in order to simplify the problem without significantly affecting the global response of the system. An anisotropic hyperelastic model was used to characterize the material behaviour; the muscle fibres were assumed to be mostly orientated circumferentially. In addition, particular attention was also put to the boundary conditions of the model. The introduction of the constraints imposed by the coccyx bone in the central area of the levator ani group represents one the most important improvement compared to previous computational models. The maximum deformation and stress were found in the pubococcygeus muscle of the levator ani group. A stretch value close to 2.2 was determined by considering different material parameters. The results seem convincing with respect to medical observation and previous analysis. However, there are still some limitations concerning the material definition and the geometry and trajectory of the head that can be further improved. PMID:24793220

  7. Characterising M?ori nursing practice.

    PubMed

    Simon, Victoria

    2006-09-01

    This paper summarises research which addresses the question What might constitute M?ori nursing practice? The research design adopted was influenced by Kaupapa M?ori methodology and used a semi-structured, qualitative, in-depth interview process. It was found that by understanding the current experiences of M?ori registered nurses, their reflections on their preparation for practice, and their current practice, we are able to identify the present and future training and practice needs of M?ori nurses. M?ori nursing practice can be characterised as having five features: the promotion of cultural affirmation including cultural awareness and identity; the support of, and access to M?ori networks; the adoption of M?ori models of health; the enabling of visibility and pro-activity as M?ori nurses; and, the validation of M?ori nurses as effective health professionals. Three recommendations for promoting M?ori nursing practice are made in relation to staff in the workplace and in nurse education programmes. All nursing staff need to be alert to: 1. The impact of western scientific models on M?ori healthcare; 2. The (often passive) non-acceptance of M?ori within mainstream institutions; and 3. The benefits of valuing Indigenous nursing programmes. PMID:17026427

  8. Sexual dimorphism of the levator veli palatini muscle: an imaging study.

    PubMed

    Perry, Jamie L; Kuehn, David P; Sutton, Bradley P; Gamage, Jinadasa K

    2014-09-01

    Objective : Magnetic resonance imaging studies of the levator veli palatini muscle have used small numbers of subjects and have not consistently controlled for sex, race, or age. The purpose of this study was to conduct a structural assessment using a large homogeneous sample to examine the sex differences in the levator muscle morphology. Methods : Thirty white adult subjects (15 men and 15 women) were imaged using a 3 Tesla MRI system. A high-resolution SPACE (sampling perfection with application-optimized contrasts using different flip-angle evolution) sequence was used to acquire images of the velopharyngeal anatomy. Levator muscle measurements were obtained. Results : Men displayed significantly greater levator extravelar segment length (P = .003), levator intravelar segment muscle length (P < .001), greater distance between levator insertion points (P < .001), and greater angles of origin (P = .008) compared with women. There was no statistically significant variation between men and women in the distance between points of origin at the base of the skull. Conclusions : This study provides normative data to improve understanding of levator dysmorphology such as that in cleft palate muscle anatomy. Results of the study demonstrate significant differences between white men and women across several levator muscle measures. Variations in the relative size of the cranium or height of the individual were not proportionate to the variations observed in the levator muscle. PMID:23782419

  9. Sexual Dimorphism of the Levator Veli Palatini Muscle: An Imaging Study

    PubMed Central

    Perry, Jamie L.; Kuehn, David P.; Sutton, Bradley P.; Gamage, Jinadasa K.

    2015-01-01

    Objective Magnetic resonance imaging studies of the levator veli palatini muscle have used small numbers of subjects and have not consistently controlled for sex, race, or age. The purpose of this study was to conduct a structural assessment using a large homogeneous sample to examine the sex differences in the levator muscle morphology. Methods Thirty white adult subjects (15 men and 15 women) were imaged using a 3 Tesla MRI system. A high-resolution SPACE (sampling perfection with application-optimized contrasts using different flip-angle evolution) sequence was used to acquire images of the velopharyngeal anatomy. Levator muscle measurements were obtained. Results Men displayed significantly greater levator extravelar segment length (P = .003), levator intravelar segment muscle length (P < .001), greater distance between levator insertion points (P < .001), and greater angles of origin (P= .008) compared with women. There was no statistically significant variation between men and women in the distance between points of origin at the base of the skull. Conclusions This study provides normative data to improve understanding of levator dysmorphology such as that in cleft palate muscle anatomy. Results of the study demonstrate significant differences between white men and women across several levator muscle measures. Variations in the relative size of the cranium or height of the individual were not proportionate to the variations observed in the levator muscle. PMID:23782419

  10. PubMed Central

    KOLTSIDOPOULOS, P.; TSEA, M.; KAFKI, S.; SKOULAKIS, C.

    2013-01-01

    SUMMARY Intramuscular haemangiomas are benign malformations of blood vessels occurring in skeletal muscles. Because of the rarity of these lesions, their deep location and variable clinical presentation, they often pose diagnostic difficulties. We herein present the first reported case of intramuscular haemangioma occurring in the levator anguli oris muscle. A 26-year-old man was referred to our Department for evaluation and management of a progressive swelling of the right cheek. Based mainly on the imaging findings, a preoperative diagnosis of intramuscular haemangioma was made and surgery was performed. During intervention, a highly vascular soft tissue mass was identified within the levator anguli oris muscle. The lesion was completely removed via an intraoral approach, and histopathological examination showed an intramuscular haemangioma. PMID:24227903

  11. FLAMES spectroscopy of low-mass stars in the young clusters ? Ori and ? Ori

    NASA Astrophysics Data System (ADS)

    Sacco, G. G.; Franciosini, E.; Randich, S.; Pallavicini, R.

    2008-09-01

    Aims: We performed a detailed membership selection and studied the accretion properties of low-mass stars in the two apparently very similar young (1-10 Myr) clusters ? Ori and ? Ori. Methods: We observed 98 and 49 low-mass (0.2-1.0 M?) stars in ? Ori and ? Ori respectively, using the multi-object optical spectrograph FLAMES at the VLT, with the high-resolution (R 17 000) HR15N grating (6470-6790 ). We used radial velocities, Li and H? to establish cluster membership and H? and other optical emission lines to analyze the accretion properties of members. Results: We identified 65 and 45 members of the ? Ori and ? Ori clusters, respectively, and discovered 16 new candidate binary systems. We also measured rotational broadening for 20 stars and estimated the mass accretion rates in 25 stars of the ? Ori cluster, finding values between 10-11 and 10-7.7~M? yr-1 and in 4 stars of the ? Ori cluster, finding values between 10-11 and 10-10.1~M? yr-1. Comparing our results with the infrared photometry obtained by the Spitzer satellite, we find that the fraction of stars with disks and the fraction of active disks is larger in the ? Ori cluster (529% and 7816%) than in ? Ori (288% and 4020%). Conclusions: The different disk and accretion properties of the two clusters could be due either to the effect of the high-mass stars and the supernova explosion in the ? Ori cluster or to different ages of the cluster populations. Further observations are required to draw a definitive conclusion. Based on Data collected at the ESO Very Large Telescope, Paranal Observatory, Chile [programs 074.D-0136(A) and 076.C-0125(A)]. Tables 1, 2 and 4-7 are only available in electronic form at http://www.aanda.org

  12. Mild dystrophic damage in the androgen-sensitive levator ani muscle of the mdx mouse.

    PubMed

    Souccar, Caden; Gonçalo, Maria Do Carmo; Buck, Hudson De Sousa; Lima-Landman, Maria Teresa R; Lapa, Antonio José

    2005-01-01

    The time course of muscular dystrophy on the androgen-sensitive levator ani muscle was compared to that of the diaphragm of dystrophic (mdx) mice aged 1-20 months. Muscle growth, isometric contractile properties and caffeine-induced contractures were determined to assess the hormone myotrophic effect, muscle strength and sarcoplasmic reticulum function, respectively, of both control and dystrophic muscles. Histological analysis of mdx muscles showed variable fiber size, centronucleated cells, infiltration of connective tissue, and necrosis which was less severe in the levator ani than in the diaphragm muscle. Tetanic tension per unit weight in the mdx levator ani was reduced (29%) after aging, while the contraction time remained unchanged. The tetanic tension of the mdx diaphragm muscle decreased with age from 3 to 20 months (20-64%), and the relaxation time was prolonged after aging (22%). Gonadectomy of young adult mdx mice caused atrophy of the levator ani muscle, accelerated muscle wasting, reduced the tetanic force (31%), but it did not affect the contraction time and caffeine responses. The results showed that testosterone does not prevent the progress of muscle disease in the mdx levator ani, but androgen withdrawal accelerates muscle wasting suggesting a normonal beneficial effect. PMID:15639121

  13. Androgen-estrogen synergy in rat levator ani muscle Glucose-6-phosphate dehydrogenase

    NASA Technical Reports Server (NTRS)

    Max, S. R.

    1984-01-01

    The effects of castration and hormone administration on the activity of glucose-6-phosphate dehydrogenase in the rat levator ani muscle were studied. Castration caused a decrease in enzyme activity and in wet weight of the levator ani muscle. Chronic administration of testosterone propionate increased glucose-6-phosphate dehydrogenase activity in the levator ani muscle of castrated rats; the magnitude of the recovery of enzyme activity was related to the length of time of exposure to testosterone propionate after castration as well as to the length of time the animals were castrated. The longer the period of castration before exposure to testosterone propionate, the greater the effect. This result may be related to previously reported castration-mediated increases in androgen receptor binding in muscle. Dihydrotestosterone was less effective than testosterone propionate in enhancing glucose-6-phosphate dehydrogenase activity in the levator ani muscle from castrated rats; estradiol-17-beta alone was ineffective. Combined treatment with estradiol-17-beta and dihydrotestosterone, however, was as effective as testosterone alone. Thus, androgens and estrogens may exert synergistic effects on levator ani muscle.

  14. Thyroid Eye Disease With Significant Levator Involvement and Ptosis: A Case Report.

    PubMed

    Scruggs, Ryan T; Black, Evan H

    2015-01-01

    A case of an 87-year-old woman with a history of Graves disease presenting with a 5-year history of severe ptosis and very poor levator function of the left side is presented. MRI revealed marked enlargement of all extraocular muscles and significant enlargement of the left levator muscle. Given the patient's age and atypical presentation of thyroid eye disease (TED), she was taken to the operating room for biopsy and ptosis repair with frontalis suspension. Histopathological analysis revealed chronic inflammation and fibrosis consistent with Graves disease. PMID:24896772

  15. Pelvic Floor Ultrasound Imaging: Are Physiotherapists Interchangeable in the Assessment of Levator Hiatal Biometry?

    PubMed Central

    Gentilcore-Saulnier, Evelyne; Auchincloss, Cindy; McLean, Linda

    2014-01-01

    ABSTRACT Purpose: To evaluate inter-examiner reliability in the ultrasound (US) assessment of levator hiatal dimensions when different physiotherapists perform independent data acquisition and analysis. Methods: In this cross-sectional observational study, 14 asymptomatic nulliparous women were imaged at rest, during pelvic floor muscle contraction, and during Valsalva manoeuvre by two physiotherapists using three-dimensional (3D) and four-dimensional (4D) transperineal US. Examiners each measured the dimensions of the levator hiatus (area and antero-posterior and transverse diameters) from the US volumes they respectively acquired. Inter-examiner reliability was determined using intra-class correlation coefficients (ICCs), and inter-examiner agreement was determined using BlandAltman analyses. Results: The ICC results demonstrated very good inter-examiner reliability (ICC=0.840.98); BlandAltman results showed high inter-examiner agreement across all measurements. Conclusions: Trained examiners may be considered interchangeable in the US assessment of levator hiatal biometry. Overall, trained physiotherapists using transperineal US imaging to assess levator hiatal biometry can be confident when comparing their own clinical findings to those of their colleagues and to findings published in the literature. PMID:25922555

  16. Appearance of the Levator Ani Muscle Subdivisions in Magnetic Resonance Images

    PubMed Central

    Margulies, Rebecca U.; Hsu, Yvonne; Kearney, Rohna; Stein, Tamara; Umek, Wolfgang H.; DeLancey, John O. L.

    2006-01-01

    OBJECTIVE Identify and describe the separate appearance of 5 levator ani muscle subdivisions seen in axial, coronal, and sagittal magnetic resonance imaging (MRI) scan planes. METHODS Magnetic resonance scans of 80 nulliparous women with normal pelvic support were evaluated. Characteristic features of each Terminologia Anatomicalisted levator ani component were determined for each scan plane. Muscle component visibility was based on pre-established criteria in axial, coronal, and sagittal scan planes: 1) clear and consistently visible separation or 2) different origin or insertion. Visibility of each of the levator ani subdivisions in each scan plane was assessed in 25 nulliparous women. RESULTS In the axial plane, the puborectal muscle can be seen lateral to the pubovisceral muscle and decussating dorsal to the rectum. The course of the puboperineal muscle near the perineal body is visualized in the axial plane. The coronal view is perpendicular to the fiber direction of the puborectal and pubovisceral muscles and shows them as clusters of muscle on either side of the vagina. The sagittal plane consistently demonstrates the puborectal muscle passing dorsal to the rectum to form a sling that can consistently be seen as a bump. This plane is also parallel to the pubovisceral muscle fiber direction and shows the puboperineal muscle. CONCLUSION The subdivisions of the levator ani muscle are visible in MRI scans, each with distinct morphology and characteristic features. PMID:16648412

  17. Morphology of the Levator Veli Palatini Muscle Using Magnetic Resonance Imaging

    PubMed Central

    Perry, Jamie L.; Kuehn, David P.; Sutton, Bradley P.

    2015-01-01

    Background No studies have reported the circumference and diameter of the levator veli palatini muscle at multiple points along its length and from both views (frontal and lateral). The purpose of this study was to provide quantitative data regarding the levator muscle morphology along the length of the muscle using magnetic resonance imaging and advanced three-dimensional computer technology. Methods Ten Caucasian male subjects participated in the study. Subjects were scanned using a Siemens 3 T Trio. Levator muscle measures were obtained using a two-dimensional image plane. A three-dimensional model was used to measure the circumference and muscle diameter (in two directions) at six points along the length of the levator muscle. Results Levator muscle length ranged from 41.67 mm to 52.85 mm across all subjects. Mean extravelar muscle length was 30.55 mm (SD, 2.8 mm) and 30.01 mm (SD, 2.9 mm) for right and left muscles. The mean circumference at the origin was 18.90 mm (SD, 2.6 mm). At the second point, the muscle circumference mean increased slightly (mean, 22.40 mm; SD, 4.9 mm). The means for the remainder of the measures (points 3, 4, 5, and 6) were consistent, showing little to no change. Conclusion Circumference and diameter values were similar to those reported in previous literature. The muscle did diverge at the point where the muscle bundle entered the velum, as it has been previously described. Instead, the muscle diverges near the midline insertion becoming sparser (smaller superior-to-inferior diameter). PMID:22023112

  18. A Geometric Capacity-Demand Analysis of Maternal Levator Muscle Stretch Required for Vaginal Delivery.

    PubMed

    Tracy, Paige V; DeLancey, John O; Ashton-Miller, James A

    2016-02-01

    Because levator ani (LA) muscle injuries occur in approximately 13% of all vaginal births, insights are needed to better prevent them. In Part I of this paper, we conducted an analysis of the bony and soft tissue factors contributing to the geometric "capacity" of the maternal pelvis and pelvic floor to deliver a fetal head without incurring stretch injury of the maternal soft tissue. In Part II, we quantified the range in demand, represented by the variation in fetal head size and shape, placed on the maternal pelvic floor. In Part III, we analyzed the capacity-to-demand geometric ratio, g, in order to determine whether a mother can deliver a head of given size without stretch injury. The results of a Part I sensitivity analysis showed that initial soft tissue loop length (SL) had the greatest effect on maternal capacity, followed by the length of the soft tissue loop above the inferior pubic rami at ultimate crowning, then subpubic arch angle (SPAA) and head size, and finally the levator origin separation distance. We found the more caudal origin of the puborectal portion of the levator muscle helps to protect it from the stretch injuries commonly observed in the pubovisceral portion. Part II fetal head molding index (MI) and fetal head size revealed fetal head circumference values ranging from 253 to 351?mm, which would increase up to 11?mm upon face presentation. The Part III capacity-demand analysis of g revealed that, based on geometry alone, the 10th percentile maternal capacity predicted injury for all head sizes, the 25th percentile maternal capacity could deliver half of all head sizes, while the 50th percentile maternal capacity could deliver a head of any size without injury. If ultrasound imaging could be operationalized to make measurements of ratio g, it might be used to usefully inform women on their level of risk for levator injury during vaginal birth. PMID:26746116

  19. The circumstellar environment of UX ORI

    NASA Astrophysics Data System (ADS)

    Natta, A.; Prusti, T.; Neri, R.; Thi, W. F.; Grinin, V. P.; Mannings, V.

    1999-10-01

    This paper presents new observations of UX Ori obtained with the millimeter interferometer of Plateau de Bure and with ISO. UX Ori is the prototype of a group of pre-main-sequence, intermediate-mass stars, often indicated as precursors of beta Pic. The interferometry observations at 1.2 and 2.6 mm show that UX Ori has a circumstellar disk, with outer radius ~ less 100 AU. We determine the spectral index between these two wavelengths to be 2.1+/-0.2, consistent with the disk being optically thick at mm wavelengths. Alternatively, the disk solid matter can be in the form of ``pebbles" (radius ~ 10 cm). In both cases most of the disk mass must be in gas form, and small grains must be present, at least in the disk atmosphere. In both cases also, the disk must be rather massive ( ~ great 0.1 M_sun). The existence of a circumstellar disk supports the model of the UXOR phenomenon in terms of a star+disk system. Self-consistent models of almost edge-on disks account well for the observed emission at all wavelengths longer than about 8mu m, if we include the emission of the optically thin, superheated layers that enshroud the disk. These rather simple disk models fail to account for the strong emission observed in the near-IR (i.e., between ~ 2 and 7 mu m), and we suggest a number of possible explanations. Based in part on observations obtained with ISO. ISO is an ESA project with instruments funded by ESA Member States (especially the PI countries: France, Germany, the Netherlands and the United Kingdom) and with the participation of ISAS and NASA.

  20. Evidence of ancillary trigeminal innervation of levator palpebrae in the general population.

    PubMed

    Lehman, A M; Dong, C C; Harries, A M; Patel, A; Honey, C R; Patel, M S

    2014-02-01

    The cranial synkineses are a group of disorders encompassing a variety of involuntary co-contractions of the facial, masticatory, or extraocular muscles that occur during a particular volitional movement. The neuroanatomical pathways for synkineses largely remain undefined. Our studies explored a normal synkinesis long observed in the general population - that of jaw opening during efforts to open the eyelids widely. To document this phenomenon, we observed 186 consecutive participants inserting or removing contact lenses to identify jaw opening. Seeking electrophysiological evidence, in a second study we enrolled individuals undergoing vascular decompression for trigeminal neuralgia or hemifacial spasm, without a history of jaw-winking, ptosis, or strabismus, to record any motor responses in levator palpebrae superioris (LPS) upon stimulation of the trigeminal motor root. Stimulus was applied to the trigeminal motor root while an electrode in levator recorded the response. We found that 37 participants (20%) opened their mouth partially or fully during contact lens manipulation. In the second study, contraction of LPS with trigeminal motor stimulation was documented in two of six patients, both undergoing surgery for trigeminal neuralgia. We speculate these results might provide evidence of an endogenous synkinesis, indicating that trigeminal-derived innervation of levator could exist in a significant minority of the general population. Our observations demonstrate plasticity in the human cranial nerve innervation pattern and may have implications for treating Marcus Gunn jaw-winking. PMID:24120706

  1. A possible role for endogenous glucocorticoids in orchiectomy-induced atrophy of the rat levator ani muscle: Studies with RU38486, a potent and selective antiglucocorticoid

    NASA Technical Reports Server (NTRS)

    Konagaya, M.; Max, S. R.

    1985-01-01

    RU38486, a potent and selective antiglucocorticoid, was employed to study a possible role for endogenous glucocorticoids in atrophy of the levator ani muscle secondary to castration of male rats. RU38486 was shown to block (3H) triamcinolone acetonide binding to cytosol from levator ani muscle. Daily oral administration of RU38486 to castrated rats partially prevented atrophy of the levator ani muscle, as well as a decrease in RNA concentration. In a control group receiving RU38486 alone, the levator ani underwent significant (20%) hypertrophy. Administration of exogenous dexamethasone also caused pronounced atrophy of the levator ani muscle. This atrophy was prevented, to a significant degree, by simultaneous oral administration of RU38486. It is concluded that endogenous glucocorticoids, the actions of which are blocked by RU38486, may be involved in regulation of the mass of the levator ani muscle in intact rats.

  2. A possible role for endogenous glucocorticoids in orchiectomy-induced atrophy of the rat levator ani muscle - Studies with RU 38486, a potent and selective antiglucocorticoid

    NASA Technical Reports Server (NTRS)

    Konagaya, Masaaki; Max, Stephen R.

    1986-01-01

    RU38486, a potent and selective antiglucocorticoid, was employed to study a possible role for endogenous glucocorticoids in atrophy of the levator ani muscle secondary to castration of male rats. RU38486 was shown to block (3H) triamcinolone acetonide binding to cytosol from levator ani muscle. Daily oral administration of RU38486 to castrated rats partially prevented atrophy of the levator ani muscle, as well as a decrease in RNA concentration. In a control group receiving RU38486 alone, the levator ani underwent significant 20 percent hypertrophy. Administration of exogenous dexamethasone also caused pronounced atrophy of the levator ani muscle. This atrophy was prevented, to a significant degree, by simultaneous oral administration of Ru38486. It is concluded that endogenous glucocorticoids, the actions of which are blocked by RU38486, may be involved in regulation of the mass of the levator ani muscle in intact rats.

  3. Breast cancer inequities between Māori and non-Māori women in Aotearoa/New Zealand.

    PubMed

    Lawrenson, R; Seneviratne, S; Scott, N; Peni, T; Brown, C; Campbell, I

    2016-03-01

    ori women have one of the highest incidences of breast cancer in the world. This high incidence is generally unexplained although higher rates of obesity and alcohol intake are modifiable risk factors that may be important. Māori women are less likely to attend mammographic breast screening and are likely to be diagnosed with more advanced disease. This is one of the reasons for the excess mortality. Another factor is differences in the treatment pathway. Māori women are more likely to experience delay in receiving treatment, are less likely to receive radiotherapy, are more likely to be treated with a mastectomy and are less likely to adhere to long-term adjuvant endocrine therapy. However, genetic factors in Māori women do not seem to impact significantly on mortality. This review looks at the inequity between Māori and non-Māori women and addresses the causes. It proposes ways of reducing inequity through primary prevention, increased participation in breast screening and greater standardisation of the treatment pathway for women newly diagnosed with breast cancer. We believe that health system improvements will decrease barriers to health care participation for Māori women and suggest that further research into identifying and modifying obstacles within health systems is required. PMID:26918687

  4. Levator Syndrome

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  5. Levator Syndrome

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  6. Alcohol Use and Older M?ori in Aotearoa.

    PubMed

    Herbert, Sarah; Stephens, Christine

    2015-01-01

    This study investigated alcohol use, hazardous and binge drinking prevalence, and their relationships to socio-demographic variables in community dwelling older M?ori adults in New Zealand. Alcohol use, hazardous drinking, and binge drinking were assessed with the AUDIT-C in a cross-sectional postal survey of 1042 older M?ori people randomly selected from the New Zealand Electoral Roll. A total of 41.2% of all participants reported drinking at hazardous levels. Odds ratios from binomial logistic regression showed hazardous drinking was significantly more likely to occur among males, current smokers, and those with higher local self-contained network scores. Binge drinking was reported by 19.6% of the sample, with odds ratios indicating that males, current smokers, and those with higher M?ori cultural identification scores were significantly more likely to report binge drinking. The high rates of hazardous and binge drinking prevalence reported in the current study raise issues of concern when considering the health of older M?ori people. Results indicate that social networks, gender, smoking status, and M?ori cultural identification may influence hazardous and binge drinking alcohol use. However, limitations of the present study also highlight the need for more focused and in-depth research to be conducted with older M?ori people to understand the sociocultural context in which alcohol use occurs. PMID:26114657

  7. Application of ultrasound imaging of upper lip orbicularis oris muscle

    PubMed Central

    Zhang, Wen-Hao; Chen, Yuan-Yuan; Liu, Jun-Jie; Liao, Xin-Hong; Du, Yang-Chun; Gao, Yong

    2015-01-01

    In this study, we aim to understand the morphology and structure of upper lip orbicularis oris muscle, and to provide clinical evidence for evaluating the effect of repair operation in cleft lip. Subjects included 106 healthy people and 36 postoperative patients of unilateral cleft lip. The upper lip orbicularis oris muscle was scanned using ultrasound in natural closure and pout states. Our results showed that the hierarchical structure of upper lip tissue was demonstrated clearly in ultrasonic images. After reconstruction of unilateral cleft lip, the left and right philtrum columns were still obviously asymmetric, their radian displayed clearly and showed better continuity. In the place of cleft lip side equivalent to philtrum columns, orbicularis oris muscle showed discontinuity and unclear hierarchical structure, which was replaced by hyperechoic scar tissue. The superficial layer would become thicker when pouting. In reconstructed unilateral cleft lip, the superficial layer was thinner than that of healthy controls. In normal upper lip orbicularis oris muscle, the superficial layer thickness was no less than 2.89 mm in philtrum dimple and no less than 3.92 mm in philtrum column, and the deep layer thickness was no less the 1.12 mm. Otherwise, the layer thickness less than above reference values may be considered as diagnostic criteria for dysplasia of upper lip orbicularis oris muscle. In conclusions, ultrasound imaging is able to clearly show the hierarchical structure of upper lip orbicularis oris muscle, and will be beneficial in guiding the upper lip repair and reconstruction surgery. PMID:26064229

  8. In vivo visualization of the levator ani muscle subdivisions using MR fiber tractography with diffusion tensor imaging

    PubMed Central

    Rousset, Pascal; Delmas, Vincent; Buy, Jean-Nol; Rahmouni, Alain; Vadrot, Dominique; Deux, Jean-Franois

    2012-01-01

    Understanding the levator ani complex architecture is of major clinical relevance. The aim of this study was to determine the feasibility of magnetic resonance (MR) fiber tractography with diffusion tensor imaging (DTI) as a tool for the three-dimensional (3D) representation of normal subdivisions of the levator ani. Ten young nulliparous female volunteers underwent DTI at 1.5 T MR imaging. Diffusion-weighted axial sequence of the pelvic floor was performed with additional T2-weighted multiplanar sequences for anatomical reference. Fiber tractography for visualization of each Terminologia Anatomica-listed major levator ani subdivision was performed. Numeric muscular fibers extracted after tractography were judged as accurate when localized within the boundaries of the muscle, and inaccurate when projecting out of the boundaries of the muscle. From the fiber tracking of each subdivision the number of numeric fibers (inaccurate and accurate) and a score (from 3 to 0) of the adequacy of the 3D representation were calculated. All but two volunteers completed the protocol. The mean number of accurate fibers was 17 2 for the pubovisceralis, 14 6 for the puborectalis and 1 1 for the iliococcygeus. The quality of the 3D representation was judged as good (score = 2) for the pubovisceralis and puborectalis, and inaccurate (score = 0) for the iliococcygeus. Our study is the first step to a 3D visualization of the three major levator ani subdivisions, which could help to better understand their in vivo functional anatomy. PMID:22757638

  9. In vivo visualization of the levator ani muscle subdivisions using MR fiber tractography with diffusion tensor imaging.

    PubMed

    Rousset, Pascal; Delmas, Vincent; Buy, Jean-Nol; Rahmouni, Alain; Vadrot, Dominique; Deux, Jean-Franois

    2012-09-01

    Understanding the levator ani complex architecture is of major clinical relevance. The aim of this study was to determine the feasibility of magnetic resonance (MR) fiber tractography with diffusion tensor imaging (DTI) as a tool for the three-dimensional (3D) representation of normal subdivisions of the levator ani. Ten young nulliparous female volunteers underwent DTI at 1.5 T MR imaging. Diffusion-weighted axial sequence of the pelvic floor was performed with additional T2-weighted multiplanar sequences for anatomical reference. Fiber tractography for visualization of each Terminologia Anatomica-listed major levator ani subdivision was performed. Numeric muscular fibers extracted after tractography were judged as accurate when localized within the boundaries of the muscle, and inaccurate when projecting out of the boundaries of the muscle. From the fiber tracking of each subdivision the number of numeric fibers (inaccurate and accurate) and a score (from 3 to 0) of the adequacy of the 3D representation were calculated. All but two volunteers completed the protocol. The mean number of accurate fibers was 17 2 for the pubovisceralis, 14 6 for the puborectalis and 1 1 for the iliococcygeus. The quality of the 3D representation was judged as good (score = 2) for the pubovisceralis and puborectalis, and inaccurate (score = 0) for the iliococcygeus. Our study is the first step to a 3D visualization of the three major levator ani subdivisions, which could help to better understand their in vivo functional anatomy. PMID:22757638

  10. Comparison of muscle fiber directions between different levator ani muscle subdivisions: in vivo MRI measurements in women

    PubMed Central

    Kim, Jinyong; Miller, Janis M.; Ashton-Miller, James A.; DeLancey, John O. L.

    2014-01-01

    Introduction and hypothesis This study describes a technique to quantify muscle fascicle directions in the levator ani (LA) and tests the null hypothesis that the in vivo fascicle directions for each LA subdivision subtend the same parasagittal angle relative to a horizontal reference axis. Methods Visible muscle fascicle direction in the each of the three LA muscle subdivisions, the pubovisceral (PVM; synonymous with pubococcygeal), puborectal (PRM), and iliococcygeal (ICM) muscles, as well as the external anal sphincter (EAS), were measured on 3-T sagittal MRI images in a convenience sample of 14 healthy women in whom muscle fascicles were visible. Mean standard deviation (SD) angle values relative to the horizontal were calculated for each muscle subdivision. Repeated measures ANOVA and post-hoc paired t tests were used to compare muscle groups. Results Pubovisceral muscle fiber inclination was 418.0, PRM was ?1910.1, ICM was 338.8, and EAS was ?436.4. These fascicle directions were statistically different (p<0.001). Pairwise comparisons among levator subdivisions showed angle differences of 60 between PVM and PRM, and 52 between ICM and PRM. An 84 difference existed between PVM and EAS. The smallest angle difference between levator divisions was between PVM and ICM 8. The difference between PRM and EAS was 24. All pairwise comparisons were significant (p<0.001). Conclusions The null hypothesis that muscle fascicle inclinations are similar in the three subdivisions of the levator ani and the external anal sphincter was rejected. The largest difference in levator subdivision inclination, 60, was found between the PVM and PRM. PMID:24832855

  11. Interaction between Apical Supports and Levator Ani in Anterior Vaginal Support: Theoretical Analysis

    PubMed Central

    Chen, Luyun; Ashton-Miller, James A.; Hsu, Yvonne; DeLancey, John O. L.

    2009-01-01

    Objective To use a biomechanical model to explore how impairment of the pubovisceral portion of the levator ani muscle and/or the apical vaginal suspension might interact to affect anterior vaginal wall prolapse severity. Method A biomechanical model of the anterior vaginal wall and its support system was developed and implemented. The anterior vaginal wall and main muscular and connective tissue support elements, namely the levator plate, pubovisceral muscle, cardinal and uterosacral ligaments, were included and their geometry based on mid-sagittal plane magnetic resonance scans. Material properties were based on published data. The change in the sagittal profile of the anterior vaginal wall during a maximum Valsalva was then simulated when different combinations of muscle and connective tissue impairment were present. Results Under raised intra-abdominal pressure, the magnitude of anterior vaginal wall prolapse was shown to be a combined function of both pubovisceral muscle and uterosacral and/or cardinal ligament (apical supports) impairment. Once a certain degree of pubovisceral impairment was reached, the genital hiatus opened and a prolapse developed. The larger the pubovisceral impairment, the larger the anterior wall prolapse became. A 90% impairment of apical support led to an increase in anterior wall prolapse from 0.3 cm to 1.9 cm (a 530% increase) at 60% pubovisceral muscle impairment, and from 0.7 cm to 2.4 cm (a 240% increase) at 80% pubovisceral muscle impairment. Conclusions These results suggest that a prolapse can develop as a result of impairment of the muscular and apical supports of the anterior vaginal wall. PMID:16880302

  12. [Isaac Newton's Anguli Contactus method].

    PubMed

    Wawrzycki, Jarosław

    2014-01-01

    In this paper we discuss the geometrical method for calculating the curvature of a class of curves from the third Book of Isaac Newton's Principia. The method involves any curve which is generated from an elementary curve (actually from any curve whose curvature we known of) by means of transformation increasing the polar angular coordinate in a constant ratio, but unchanging the polar radial angular coordinate. PMID:25033525

  13. OriDB: a DNA replication origin database.

    PubMed

    Nieduszynski, Conrad A; Hiraga, Shin-ichiro; Ak, Prashanth; Benham, Craig J; Donaldson, Anne D

    2007-01-01

    Replication of eukaryotic chromosomes initiates at multiple sites called replication origins. Replication origins are best understood in the budding yeast Saccharomyces cerevisiae, where several complementary studies have mapped their locations genome-wide. We have collated these datasets, taking account of the resolution of each study, to generate a single list of distinct origin sites. OriDB provides a web-based catalogue of these confirmed and predicted S.cerevisiae DNA replication origin sites. Each proposed or confirmed origin site appears as a record in OriDB, with each record comprising seven pages. These pages provide, in text and graphical formats, the following information: genomic location and chromosome context of the origin site; time of origin replication; DNA sequence of proposed or experimentally confirmed origin elements; free energy required to open the DNA duplex (stress-induced DNA duplex destabilization or SIDD); and phylogenetic conservation of sequence elements. In addition, OriDB encourages community submission of additional information for each origin site through a User Notes facility. Origin sites are linked to several external resources, including the Saccharomyces Genome Database (SGD) and relevant publications at PubMed. Finally, a Chromosome Viewer utility allows users to interactively generate graphical representations of DNA replication data genome-wide. OriDB is available at www.oridb.org. PMID:17065467

  14. Bacteriologic and clinical study of Bacteroides oris and Bacteroides buccae.

    PubMed Central

    Johnston, B L; Edelstein, M A; Holloway, E Y; Finegold, S M

    1987-01-01

    We characterized clinical isolates previously identified in our laboratory as Bacteroides ruminicola, the human strains of which are now classified as Bacteroides oris and Bacteroides buccae. A total of 72 isolates (55 B. buccae isolates and 17 B. oris isolates) recovered over a 10-year period were studied. They were differentiated from each other by special-potency antibiotic disks and the RapID-ANA system. The two organisms were associated with a variety of infections, the majority being pleuropulmonary (29.2%) and infections of the head and neck region (27.8%). The infections were always polymicrobial, usually with more than five organisms per specimen. A total of 44% of the B. oris strains and 27% of the B. buccae strains were resistant to penicillin G (breakpoint, 2 U/ml), and this correlated with the presence of beta-lactamase. Although B. oris and B. buccae are found with some frequency in human infections, they are present primarily as components of a mixed flora. PMID:3571453

  15. Rapid variability of the EXor star NY Ori

    NASA Astrophysics Data System (ADS)

    Lorenzetti, D.; Arkharov, A. A.; Efimova, N.; Giannini, T.; Antoniucci, S.; Di Paola, A.; Larionov, V. M.

    2016-03-01

    We report on a rapid brightness variability of the classical EXor star NY Ori observed with the AZT24 1m IR telescope (Campo Imperatore, Italy), as a part of our program EXORCISM (EXOR OptiCal and Infrared Systematic Monitoring - Antoniucci et al. 2013 PPVI; Lorenzetti et al. 2009 ApJ 693, 1056).

  16. 42 CFR 93.402 - ORI allegation assessments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false ORI allegation assessments. 93.402 Section 93.402 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of...

  17. 42 CFR 93.402 - ORI allegation assessments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false ORI allegation assessments. 93.402 Section 93.402 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of...

  18. The Herbig Be Star V1818 Ori and Its Environment

    NASA Astrophysics Data System (ADS)

    Chiang, Hsin-Fang; Reipurth, Bo; Hillenbrand, Lynne

    2015-03-01

    The little-studied Herbig Be star V1818 Ori is located in the direction of the southern L1641 cloud and the Mon R2 star-forming complex, and is most likely associated with the latter at a distance of ˜900 pc. A high-resolution spectrum is consistent with a spectral type around B7 V, with lines of Hα, the red Ca ii triplet, and several forbidden lines in emission. An All Sky Automated Survey V-band light curve spanning 9 yr reveals major variability with deep absorption episodes reminiscent of the UX Orionis stars. We have searched for additional young stars clustering around V1818 Ori using grism images and the 2MASS and Wide-field Infrared Survey Explorer catalogs, and have found almost two dozen fainter stars with evidence of youth. Direct images show that the bright star IRAS 05510-1025, only about 3 arcmin from V1818 Ori, is surrounded by a reflection nebula, indicating its association with a molecular cloud. A spectrum of the star shows no emission-lines, and it is found to be a close binary with late B and early G type components. Its radial velocity indicates that it is an interloper, accidentally passing through the cloud and not physically associated with V1818 Ori.

  19. Measurement of the 3D geometry of the fascial arches in women with a unilateral levator defect and architectural distortion

    PubMed Central

    LARSON, Kindra A.; LUO, Jiajia; YOUSUF, Aisha; ASHTON-MILLER, James A.; DeLANCEY, John O.L.

    2013-01-01

    Objective The arcus tendineus fascia pelvis (ATFP) and arcus tendineus levator ani (ATLA) are elements of anterior vaginal support. This study describes their geometry in women with unilateral levator ani muscle defects and associated architectural distortion. Study Design Fourteen subjects with unilateral defects underwent MRI. 3-D models of the arcus were generated. Locations of these relative to an ilial reference line were compared between unaffected and affected sides. Results Pronounced changes occurred on the defect sides ventral region. The furthest point of the ATLA lay up to a mean 10.2mm (p=0.01) more inferior and 6.5mm (p=0.02) more medial than that on the intact side. Similarly, the ATFP lay 6 mm (p=0.01*) more inferior than on the unaffected side. Conclusion The ventral arcus anatomy is significantly altered in the presence of levator defects and architectural distortion. Alterations of these key fixation points will change supportive force direction along the lateral anterior vaginal wall, increasing the risk for anterior vaginal wall prolapse. PMID:21818620

  20. 42 CFR 93.315 - Notice to ORI of institutional findings and actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Notice to ORI of institutional findings and actions... HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of Institutions The Institutional Investigation 93.315 Notice to ORI of institutional findings and actions. The institution must give ORI...

  1. 42 CFR 93.315 - Notice to ORI of institutional findings and actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Notice to ORI of institutional findings and actions... HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of Institutions The Institutional Investigation 93.315 Notice to ORI of institutional findings and actions. The institution must give ORI...

  2. The Urethral Rhabdosphincter, Levator Ani Muscle, and Perineal Membrane: A Review

    PubMed Central

    Hinata, Nobuyuki; Murakami, Gen

    2014-01-01

    Detailed knowledge of the anatomy of the rhabdosphincter and adjacent tissues is mandatory during urologic surgery to ensure reliable oncologic and functional outcomes. To characterize the levator ani (LA) function for the urethral sphincter, we described connective tissue morphology between the LA and urethral rhabdosphincter. The interface tissue between the LA and rhabdosphincter area in males contained abundant irregularly arrayed elastic fibers and smooth muscles. The male rhabdosphincter was positioned alongside the LA to divide the elevation force and not in-series along the axis of LA contraction. The male perineal membrane was thin but solid and extends along the inferior margin or bottom of the rhabdosphincter area. In contrast, the female rhabdosphincter, including the compressor urethrae and urethrovaginal sphincter muscles, was embedded in the elastic fiber mesh that is continuous with the thick, multilaminar perineal membrane. The inferomedial edge of the female LA was attached to the upper surface of the perineal membrane and not directly attached to the rhabdosphincter. We presented new diagrams showing the gender differences in topographical anatomy of the LA and rhabdosphincter. PMID:24877147

  3. Abnormal eye movements in blepharospasm and involuntary levator palpebrae inhibition. Clinical and pathophysiological considerations.

    PubMed

    Aramideh, M; Bour, L J; Koelman, J H; Speelman, J D; Ongerboer de Visser, B W

    1994-12-01

    We report on four patients with involuntary eyelid closure and eye movement disorders. Three were healthy until the onset of their illness and one had a mild generalized choreoathetosis and dystonia due to kernicterus. Electromyographic recording revealed solely blepharospasm in two patients and blepharospasm in combination with involuntary levator palpebrae inhibition in the other two. The eye movement abnormalities were clinically characterized by inability to fix gaze and short or prolonged episodes of uncontrollable eye deviations accompanied, in two patients, by diplopia in horizontal or vertical directions. These episodes occurred independently of a disorder of eyelid movement. Eye movement recordings with a double magnetic induction technique showed saccadic intrusions in horizontal directions. They consisted of highly frequent square wave jerks in three and sporadic macro-square wave jerks in two patients. There were also episodes of extraocular muscle dystonia, commonly known as oculogyric crises, resulting in involuntary upward eye deviation in all patients and lateral deviation in three patients. In one patient, nasal-ward deviations were sometimes restricted to one eye. We conclude that these abnormal eye movements do not necessarily point to a symptomatic form of dystonia and that they may limit the beneficial effect of botulinum toxin or surgical intervention in the therapeutic management of involuntary eyelid closure. We suggest that either basal ganglia, especially substantia nigra pars reticularis and the brainstem structures, especially the paramedian pontine reticular formation, or both, may be involved in the pathogenesis of these abnormal movements. PMID:7820580

  4. Iron-dependent gene expression in Actinomyces oris

    PubMed Central

    Mul, Matthew P.; Giacalone, David; Lawlor, Kayla; Golden, Alexa; Cook, Caroline; Lott, Thomas; Aksten, Elizabeth; O'Toole, George A.; Bergeron, Lori J.

    2015-01-01

    Background Actinomyces oris is a Gram-positive bacterium that has been associated with healthy and diseased sites in the human oral cavity. Most pathogenic bacteria require iron to survive, and in order to acquire iron in the relatively iron-scarce oral cavity A. oris has been shown to produce iron-binding molecules known as siderophores. The genes encoding these siderophores and transporters are thought to be regulated by the amount of iron in the growth medium and by the metal-dependent repressor, AmdR, which we showed previously binds to the promoter of proposed iron-regulated genes. Objective The purpose of this study was to characterize siderophore and associated iron transport systems in A. oris. Design We examined gene expression of the putative iron transport genes fetA and sidD in response to low- and high-iron environments. One of these genes, sidD, encoding a putative Fe ABC transporter protein, was insertionally inactivated and was examined for causing growth defects. To gain a further understanding of the role of iron metabolism in oral diseases, clinical isolates of Actinomyces spp. were examined for the presence of the gene encoding AmdR, a proposed global regulator of iron-dependent gene expression in A. oris. Results When A. oris was grown under iron-limiting conditions, the genes encoding iron/siderophore transporters fetA and sidD showed increased expression. One of these genes (sidD) was mutated, and the sidD::Km strain exhibited a 50% reduction in growth in late log and stationary phase cells in media that contained iron. This growth defect was restored when the sidD gene was provided in a complemented strain. We were able to isolate the AmdR-encoding gene in seven clinical isolates of Actinomyces. When these protein sequences were aligned to the laboratory strain, there was a high degree of sequence similarity. Conclusions The growth of the sidD::Km mutant in iron-replete medium mirrored the growth of the wild-type strain grown in iron-limiting medium, suggesting that the sidD::Km mutant was compromised in iron uptake. The known iron regulator AmdR is well conserved in clinical isolates of A. oris. This work provides additional insight into iron metabolism in this important oral microbe. PMID:26685151

  5. OryGenesDB: a database for rice reverse genetics.

    PubMed

    Droc, G; Ruiz, M; Larmande, P; Pereira, A; Piffanelli, P; Morel, J B; Dievart, A; Courtois, B; Guiderdoni, E; Prin, C

    2006-01-01

    Insertional mutant databases containing Flanking Sequence Tags (FSTs) are becoming key resources for plant functional genomics. We have developed OryGenesDB (http://orygenesdb.cirad.fr/), a database dedicated to rice reverse genetics. Insertion mutants of rice genes are catalogued by Flanking Sequence Tag (FST) information that can be readily accessed by this database. Our database presently contains 44166 FSTs generated by most of the rice insertional mutagenesis projects. The OryGenesDB genome browser is based on the powerful Generic Genome Browser (GGB) developed in the framework of the Generic Model Organism Project (GMOD). The main interface of our web site displays search and analysis interfaces to look for insertions in any candidate gene of interest. Several starting points can be used to exhaustively retrieve the insertions positions and associated genomic information using blast, keywords or gene name search. The toolbox integrated in our database also includes an 'anchoring' option that allows immediate mapping and visualization of up to 50 nucleic acid sequences in the rice Genome Browser of OryGenesDB. As a first step toward plant comparative genomics, we have linked the rice and Arabidopsis whole genome using all the predicted pairs of orthologs by best BLAST mutual hit (BBMH) connectors. PMID:16381969

  6. A review of Māori astronomy in Aotearoa-New Zealand

    NASA Astrophysics Data System (ADS)

    Harris, Pauline; Matamua, Rangi; Smith, Takirirangi; Kerr, Hoturoa; Waaka, Toa

    2013-11-01

    Across the world indigenous people are seeking to reclaim their traditional knowledge. Within the last fifty years the Māori of Aotearoa-New Zealand have made significant efforts to reclaim their language, arts and science. Part of this renaissance includes a growing Māori movement to reclaim their astronomical knowledge. Māori astronomical understanding was infused throughout much of pre-colonial Māori life, culture and belief. The Sun, Moon and stars were an integral part of practices pertaining to agriculture, architecture, fishing, calendrical systems and exploration. Although early ethnographers attempted to record this knowledge, their works seem to only reflect a somewhat superficial level of understanding. Thus this paper highlights some of the current research being conducted on Māori astronomy, which seeks a greater understanding of how the ancestors of the Māori perceived the heavens.

  7. Intra-eyebrow frontalis suspension using inverted Y-shaped short autogenous fascia lata for blepharoptosis with poor levator function.

    PubMed

    Shimizu, Yusuke; Nagasao, Tomohisa; Shido, Hirokazu; Fujii, Takako; Kato, Tatsuya; Aoki, Marie; Takada, Keiko; Kishi, Kazuo

    2015-01-01

    Frontalis suspension using autogenous fascia lata is a common procedure for blepharoptosis with poor levator function. However, donor-site morbidity associated with fascia lata harvest cannot be ignored. In conventional procedures, the required length of the fascia lata is usually >5-12cm with a lateral thigh skin incision of approximately 5cm or more. The present study introduces a new frontalis suspension procedure in which the required size (length and width) of the fascia lata and length of lateral thigh incision is much smaller. The harvested fascia lata is tailored to an inverted Y shape and the separated caudal legs are fixed to the tarsus while the cephalic end is grafted inside the eyebrow through a suborbital septum tunnel. In the present study, 11 patients who underwent the new procedure with a minimum of 6 months of follow-up were evaluated. The average length and width of the harvested fascia lata in unilateral ptosis cases were 2.85 and 0.89cm, respectively. The average length of the lateral thigh incision was 1.25cm. The margin reflex distance improved in all cases at 6 months postoperatively. The cosmetic result was graded as good to excellent in most of the patients. Trichiasis, widened donor scar, and eyebrow notch were noted as complications. The present method is a good alternative for the treatment of blepharoptosis with poor levator function. It potentially reduces donor-site morbidity as compared with conventional frontalis muscle suspension procedures using autogenous fascia lata. PMID:25260853

  8. Rossiter-mclaughlin effect in emission from UX Ori stars

    NASA Astrophysics Data System (ADS)

    Grinin, V. P.; Potravnov, I. S.

    2013-03-01

    The possibility of detecting changes in the radial velocities of UX Ori stars during eclipses by circumstellar dust clouds is examined. Calculations show that, despite the large sizes of the clouds, this effect may actually be observable and, perhaps, has already been observed during spectral studies of stars of this kind. Monitoring of events of this kind can provide important information about the motion of matter in close proximity to young stars, as well as about the structure of gas-dust clouds shielding a star.

  9. Mid-IR Photometry and Near-IR Spectroscopy of the FU Ori Protostar V2775 Ori (HOPS 223)

    NASA Astrophysics Data System (ADS)

    Fischer, William J.; Safron, Emily J.; Megeath, S. Thomas; Terebey, Susan; Soto, Edith; Wilson, Thomas L.; Adams, Joseph D.

    2016-02-01

    On 2015 November 20.39, we obtained mid-IR photometry of V2775 Ori (HOPS 223) with the FORCAST instrument aboard SOFIA. This is a low-mass embedded young stellar object that was reported to have undergone a luminosity outburst by Caratti o Garatti et al. (2011, A & A, 526, L1). Fischer et al. (2012, ApJ, 756, 99) dated the beginning of the outburst to between 2005 April and 2007 March and discussed the similarity of its near-IR spectrum to that of FU Orionis.

  10. Hot gas distribution in the wind of ? Pup and ? Ori

    NASA Astrophysics Data System (ADS)

    Herve, A.; Rauw, G.; Naze, Y.

    2013-06-01

    We have developped a new X-ray modelling code based on embedded shocks which computes synthetic spectra as a function of plasma temperature, abundances and localization of the X-ray emitting shell in the wind. We have also included a proper treatment of the radial dependence of the X-ray opacity of the cool matter as well as a treatment forthe Forbiden Inter combination Resonance (FIR) lines of He-like ions. Our code combines several synthetic spectra in order to fit all the lines of an X-ray spectrum simultaneously and coherently. Our results on two O-type stars ? Pup and ? Ori reveal non-porous winds with a mass loss rate consistent with studies in the optical domain as well as non-solar abundances for the CNO elements as expected for evolved stars. More important, the X-ray plasma starts emitting close to the stellarsurface. An improved version of our code allowing an analysis of the radial dependence of the hot gas filling factor reveals for ? Ori a non continuity of the X-ray emission regions associated to high values of the hot gas filling factor.

  11. Cell bodies of the trigeminal proprioceptive neurons that transmit reflex contraction of the levator muscle are located in the mesencephalic trigeminal nucleus in rats.

    PubMed

    Fujita, Kenya; Matsuo, Kiyoshi; Yuzuriha, Shunsuke; Kawagishi, Kyutaro; Moriizumi, Tetsuji

    2012-12-01

    Since the levator and frontalis muscles lack interior muscle spindles despite being antigravity mixed muscles to involuntarily sustain eyelid opening and eyebrow lifting, this study has proposed a hypothetical mechanism to compensate for this anatomical defect. The voluntary contraction of fast-twitch fibres of the levator muscle stretches the mechanoreceptors in Müller's muscle to evoke proprioception, which continuously induces reflex contraction of slow-twitch fibres of the levator and frontalis muscles. This study confirmed the presence of cell bodies of the trigeminal proprioceptive neurons that transmit reflex contraction of the levator and frontalis muscles. After confirming that severing the trigeminal proprioceptive fibres that innervate the mechanoreceptors in Müller's muscle induced ipsilateral eyelid ptosis, Fluorogold was applied as a tracer to the proximal stump of the trigeminal proprioceptive nerve in rats. Fluorogold labelled the cell bodies of the trigeminal proprioceptive neurons, not in any regions of the rat brain including the trigeminal ganglion, but in the ipsilateral mesencephalic trigeminal nucleus neighbouring the locus ceruleus. Some Fluorogold particles accumulated in the area of the locus ceruleus. The trigeminal proprioceptive neurons could be considered centrally displaced ganglion cells to transmit afferent signal from the mechanoreceptors in Müller's muscle to the mesencephalon, where they may be able to make excitatory synaptic connections with both the oculomotor neurons and the frontalis muscle motoneurons for the involuntary coordination of the eyelid and eyebrow activities, and potentially to the locus ceruleus. PMID:23157498

  12. [The establishment and meaning of the three-dimensional finite element model of pelvic floor levator ani muscle in an old healthy woman].

    PubMed

    Chen, Wei; Wn, Lijun; Yan, Zhihan; Wang, Jusong; Fu, Yalan; Chen, Xiongfei; Liu, Kun; Wu, Zhipeng

    2011-10-01

    This paper is to establish a three-dimensional finite element model (3D-FEM) of pelvic floor levator ani muscles in an old healthy women. We acquired the image data of the pelvic bones and pelvic floor muscles from CT and MRI scanning in a non-pregnant old healthy female volunteers. The 3-D reconstruction and mesh optimization of the whole pelvic bones and muscles with application of image processing software Mimics12.0 and Geomagic9.0 were obtained. Then we built the 3D-FEM of the musculoskeletal system of the pelvic bones and levator ani muscles with Ansys11.0 software. We obtained an accurate 3D-FEM of pelvic bones and levator ani muscles in the older healthy woman. The results showed that it was reliable to build 3D-FEM with CT and MRI scanning data and this model could vividly reflect the huge space anatomy of the real pelvic floor levator ani muscles. It avoids the defects to gain the model from the body of anatomical specimens in the past. The image data of model are closer to vivisection, and the model is more conducive to the latter finite element analysis. PMID:22097257

  13. Results of levator-advancement blepharoptosis repair using a standard protocol: effect of epinephrine-induced eyelid position change.

    PubMed Central

    Bartley, G B; Lowry, J C; Hodge, D O

    1996-01-01

    PURPOSE: Blepharoptosis repair by levator advancement is successful in most instances, but the postoperative eyelid level is not uniformly predictable. This study was undertaken to evaluate the possible effect of epinephrine (from local anesthetic) on eyelid position. METHODS: Seventeen adults with acquired unilateral ptosis as a result of levator aponeurosis dehiscence underwent levator aponeurosis advancement. The distance between the upper eyelid margin and the central corneal light reflex was measured preoperatively with the patient in both the upright and the supine position, 10 minutes after injection of 1.0 mL of anesthetic solution (2% lidocaine with 1:100,000 epinephrine and 12 U hyaluronidase per mL) in the supine position, intraoperatively after skin closure in the supine position, and 1 week or more postoperatively in the upright position. The ptotic lid was positioned intraoperatively in relation to the contralateral unoperated lid according to the change (presumably) induced by epinephrine stimulation of Mller's muscle. RESULTS: Eleven (65%) of the 17 patients had final postoperative lid positions within 1 mm between eyes. Two patients (12%) had undercorrection. Four patients (24%) had overcorrection by > 1 mm. The overcorrected lids were satisfactorily positioned, however, and none required further surgery; in 3 of these 4 patients, the unoperated lid had become ptotic, probably as a result of Hering's law. Differences between operated and unoperated lids and between the different times of measurement were analyzed. Significant changes in lid position occurred in the ptotic lids after injection (mean, +1.1 +/- 1.5 mm; median, +1.0 mm; P = .004) and in the final intraoperative difference between operated and unoperated lids (mean, +0.8 +/- 0.9 mm; median, +1.0 mm; P = .003). The change in the unoperated lid from preoperative upright to preoperative supine was significantly greater in the 6 failures (mean, -0.8 +/- 0.6 mm; median, -1.0 mm) than in the 11 successful outcomes (mean, +0.1 +/- 0.8 mm; median, 0.0 mm; P = .03). The change in unoperated lid position after injection of the ptotic lid was significantly greater in the failures (mean, +0.4 +/- 0.5 mm; median, +0.3 mm) than in the successful cases (mean, -0.2 +/- 0.4 mm; median, 0.0 mm; P = .02). CONCLUSION: Although it seems intuitively reasonable and clinically appropriate to account for the stimulatory effect of epinephrine during ptosis surgery, such intraoperative compensation alone did not yield a universally successful outcome in this study. PMID:8981695

  14. Design of non-isomorphic symmetric descendants of the Miura-ori

    NASA Astrophysics Data System (ADS)

    Sareh, Pooya; Guest, Simon D.

    2015-08-01

    The Miura fold pattern, or the Miura-ori, is a flat-foldable origami pattern with various applications in engineering and architecture. In addition to free-form variations, scholars have proposed a number of symmetric derivatives for this classic fold pattern over recent years. In a previous work, the authors of this paper studied isomorphic variations on the Miura-ori which led to the development of an isomorphic family for this fold pattern. In this paper, we study non-isomorphic variations on the Miura-ori in order to develop a non-isomorphic family for this pattern. Again we start with the Miura-ori, but reduce the symmetry by migrating from the original symmetry group to its subgroups, which may also include the enlargement of its unit cell. We systematically design and classify the non-isomorphic symmetric descendants of the Miura-ori which are either globally planar, or globally curved, flat-foldable tessellations.

  15. A shape guided C-V model to segment the levator ani muscle in axial magnetic resonance images.

    PubMed

    Ma, Zhen; Jorge, Renato Natal M; Tavares, João Manuel R S

    2010-09-01

    This paper proposes a modified Chan-Vese model to segment levator ani muscles from axial magnetic resonance (MR) images. Intensity variances of the foreground and the background are used as the main segmentation clues. As in most cases the boundary of the rectum can be successfully segmented in axial MR images, it is assumed as a priori and is used to define the region of interest and the initial contour. In order to handle the complex influences of the connective tissues, a shape influence field is formed based on the shape information of the rectum and is integrated into the Chan-Vese model. Several segmentation examples are presented to show the effectiveness of the proposed method and the necessity of adding the shape influences. PMID:20627794

  16. Ori-Finder 2, an integrated tool to predict replication origins in the archaeal genomes

    PubMed Central

    Luo, Hao; Zhang, Chun-Ting; Gao, Feng

    2014-01-01

    DNA replication is one of the most basic processes in all three domains of cellular life. With the advent of the post-genomic era, the increasing number of complete archaeal genomes has created an opportunity for exploration of the molecular mechanisms for initiating cellular DNA replication by in vivo experiments as well as in silico analysis. However, the location of replication origins (oriCs) in many sequenced archaeal genomes remains unknown. We present a web-based tool Ori-Finder 2 to predict oriCs in the archaeal genomes automatically, based on the integrated method comprising the analysis of base composition asymmetry using the Z-curve method, the distribution of origin recognition boxes identified by FIMO tool, and the occurrence of genes frequently close to oriCs. The web server is also able to analyze the unannotated genome sequences by integrating with gene prediction pipelines and BLAST software for gene identification and function annotation. The result of the predicted oriCs is displayed as an HTML table, which offers an intuitive way to browse the result in graphical and tabular form. The software presented here is accurate for the genomes with single oriC, but it does not necessarily find all the origins of replication for the genomes with multiple oriCs. Ori-Finder 2 aims to become a useful platform for the identification and analysis of oriCs in the archaeal genomes, which would provide insight into the replication mechanisms in archaea. The web server is freely available at http://tubic.tju.edu.cn/Ori-Finder2/. PMID:25309521

  17. The Early ALMA View of the FU Ori Outburst System

    NASA Astrophysics Data System (ADS)

    Hales, A. S.; Corder, S. A.; Dent, W. R. D.; Andrews, S. M.; Eisner, J. A.; Cieza, L. A.

    2015-10-01

    We have obtained ALMA Band 7 observations of the FU Ori outburst system at a 0.?6 0.?5 resolution to measure the link between the inner disk instability and the outer disk through submillimeter continuum and molecular line observations. Our observations detect continuum emission that can be well-modeled by two unresolved sources located at the position of each binary component. The interferometric observations recover the entire flux reported in previous single-dish studies, ruling out the presence of a large envelope. Assuming that the dust is optically thin, we derive disk dust masses of 2 10-4 M? and 8 {10}-5 M? for the north and south components, respectively. We place limits on the disks radii of r < 45 AU. We report the detection of molecular emission from 12CO(3-2), HCO+(4-3), and from HCN(4-3). The 12CO appears widespread across the two binary components and is slightly more extended than the continuum emission. The denser gas tracer HCO+ peaks close to the position of the southern binary component, while HCN appears to be peaked at the position of the northern component. This suggests that the southern binary component is embedded in denser molecular material, consistent with previous studies that indicate a heavily reddened object. At this angular resolution, any interaction between the two unresolved disk components cannot be disentangled. Higher-resolution images are vital for understanding the process of star formation via rapid accretion FU Ori-type episodes.

  18. STAR FORMATION IN THE COMETARY GLOBULE ORI I-2

    SciTech Connect

    Mookerjea, Bhaswati; Sandell, Goeran E-mail: Goran.H.Sandell@nasa.go

    2009-11-20

    We investigate the young stellar population in and near the cometary globule Ori I-2. The analysis is based on deep Nordic Optical Telescope R-band and Halpha images, JCMT SCUBA 450 and 850 mum images combined with near-infrared Two Micron All Sky Survey (2MASS) photometry and mid-infrared archival Spitzer images obtained with the Infrared Array Camera (IRAC; 3.6, 4.5, 5.8, and 8 mum), and MIPS (24 and 70 mum) instruments. We identify a total of 125 sources within the 5'x5' region imaged by the IRAC. Of these sources, 87 are detected in the R-band image and 51 are detected in the 2MASS. The detailed physical properties of the sources are explored using a combination of near/mid-infrared color-color diagrams, graybody fitting of spectral energy distributions (SEDs) and an online SED fitting tool that uses a library of two-dimensional radiation transfer based accretion models of young stellar objects with disks. Ori I-2 shows clear evidence of triggered star formation with four young low-luminosity pre-main-sequence (PMS) stars embedded in the globule. At least two, possibly as many as four, additional low-mass PMS objects were discovered in the field which are probably part of the young sigma Orionis cluster. Among the PMS stars which have formed in the globule, MIR-54 is a young, deeply embedded Class 0/I object; MIR-51 and 52 are young Class II sources, while MIR-89 is a more evolved, heavily extincted Class II object with its apparent colors mimicking a Class 0/I object. The Class 0/I object MIR-54 coincides with a previously known IRAS source and is a strong submillimeter source. It is most likely the source for the molecular outflow and the large parsec-scale Herbig-Haro (HH) flow. However, the nearby Class II source, MIR-52, which is strong a Halpha emission line star, also appears to drive an outflow approximately aligned with the outflow from MIR-54, and because of the proximity of the two outflows, either star could contribute. MIR-89 appears to excite a low-excitation HH object, HH 992, discovered for the first time in this study.

  19. UX Ori Variables in the Cluster IC 348

    NASA Astrophysics Data System (ADS)

    Barsunova, O. Yu.; Grinin, V. P.; Sergeev, S. G.; Semenov, A. O.; Shugarov, S. Yu.

    2015-06-01

    Results are presented from many years of photometric (VRCIC) observations of three variable T Tauri type stars in the cluster IC 348: V712 Per, V719 Per, and V909 Per. All three stars have photometric activity characteristic of UX Ori stars. The activity of V719 Per has increased significantly over the last 10 years: the amplitude of its Algol-like minima has increased by roughly a factor of 4 and has reached three stellar magnitudes in the I band. Periodograms of the light curves do not confirm the periods found previously by other authors on the basis of shorter series of observations. The slope of the color tracks on "color-magnitude" diagrams is used to determine the reddening law for these stars owing to selective absorption by circumstellar dust. Modelling of these parameters by the Mie theory shows that the maximum size amax of the dust particles in the protoplanetary disks of these stars is 1.5-2 times greater than in the interstellar medium. In V712 Per and V909 Per, the bulk of the mass of the dust particles is concentrated near amax, while in V719 Per the average mass of the dust particles is determined by the minimum size of the particles. It should be emphasized that these conclusions rely on an analysis of the optical variability of these stars.

  20. Absolute ultraviolet spectrophotometry of: alpha CMa, gamma Ori, kappa Ori, and alpha Leo; and a continuing calibration program and some preliminary results

    NASA Technical Reports Server (NTRS)

    Evans, D. C.

    1971-01-01

    Spectral observations of the stars alpha CMa, gamma Ori, kappa Ori, and alpha Leo have been obtained in the range 1150 to 4000 Angstroms, using rocket borne spectrometers. The payloads have a 13-inch diameter telescope, a rotatable concave diffraction grating, and three pulse counting photomultiplier photometers. The laboratory standards used as photometric references derive their primary calibration directly or indirectly from the National Bureau of Standards. An error range of up to + or - 10 percent is attributed to these laboratory standards; + or - 8 percent to the calibration procedure; and + or - 10 percent is assigned as an accidental error range.

  1. ORI2 inhibits coxsackievirus replication and myocardial inflammation in experimental murine myocarditis.

    PubMed

    Lim, Byung-Kwan; Kim, Jin Hee

    2014-01-01

    We purified ORI2 [3-(3,4-dihydroxyphenyl)acrylic acid 1-(3,4-dihydroxyphenyl)-2-methoxycarbonylethyl ester] from an extract of the plant Isodon excisus. We tested the antiviral effect of ORI2 in a coxsackievirus-induced myocarditis model. Coxsackievirus B3 (CVB3) is a common cause of myocarditis and dilated cardiomyopathy. Activation of extracellular signal-regulated kinase (ERK) and Akt signaling in virus-infected cells is essential for CVB3 replication. Antiviral compounds were screened by HeLa cell survival assay. Several purified natural compounds were added to HeLa cells cultured in 96-well plates for 30 min after 1 multiplicity of infection (m.o.i) CVB3 infection. ORI2 significantly improved HeLa cell survival in a dose-dependent manner. For in vivo studies, BALB/c mice (n=20) were infected with CVB3, then 10 of the mice were treated by daily intraperitoneal injections of ORI2 (100 mM) for 3 consecutive days. ORI2 treatment significantly improved early survival in the treated mice compared to untreated mice (85% vs. 50%, respectively). Organ virus titers and myocardial damage were significantly lower in the ORI2-treated mice than in untreated mice. These results demonstrate that ORI2, delivered by intraperitoneal injection after CVB3 infection, has a significant antiviral effect by markedly inhibiting virus replication, resulting in a decrease in organ virus titer and myocardial damage. ORI2 may be developed as a potential therapeutic agent for the treatment of CVB3 infections. PMID:25273388

  2. HsOrc4-Dependent Dna Remodeling of the ori-β Dhfr Replicator.

    PubMed

    Tomic, Branko; Kusic-Tisma, Jelena

    2015-12-01

    Replication of DNA in multicellular organisms initiates from origin of replication (ori) sequences, which significantly differ in length and complexity. One of the best characterized is hamster dihydrofolate reductase (DHFR), which contains the ori-β sequence with several functionally relevant domains, such as an AT-rich region, dinucleotide repeat element (DNR), sequence-induced bend DNA (BEND) and a RIP60 protein-binding site (RIP60). Prior to initiation, ori sequences are recognized by origin recognition complex (ORC), which is a hetero hexamer complex that serves as the landing pad for proteins of the pre-replication complex. The function of each ORC subunit is still unclear. In this study, we analyze the function of subunit 4 of the human ORC complex (HsOrc4) in interaction with a plasmid bearing the ori-β DHFR sequence. We show that the topologically closed DHFR ori-β replicator contains a bubble-like structure within its AT-rich region and that it is reversibly modified in the interaction with HsOrc4. The non-canonical structure of the AT-rich region in the topologically closed ori sequence is recognized and changed by HsOrc4 using the energy of supercoiled DNA. These findings could help to further elucidate DNA replication and its possible association with human genetic diseases. PMID:26124052

  3. [Progress of EBNA1/oriP-based plasmid applied in gene therapy].

    PubMed

    He, Jie; Zhang, Zhi-Qing

    2005-05-01

    The nonviral gene delivery systems are usually not very effective in transferring gene into target cells, and the intensity and duration of the gene expression is very poor. The EBNA1/oriP maintain EBNA1/oriP-based plasmids as episome, contribute to nuclear transport of the plasmid and transcriptional up-regulation of target gene. The EBNA1/oriP based plasmid enhances the transfection rate as well as magnitude and longevity of gene expression. This article reviews recent preclinical gene therapy studies with the EBV plasmid vectors conducted against various diseases. For gene therapy against malignancies, the EBNA1/ oriP based plasmid encoding the HSV1-TK suicide gene was combined with a cationic polymer to transfer into HCC cell line. The expression level of TK gene was 100- to 1000-fold higher than the conventional plasmid. The sensitivity of HCC to ganciclovir (GCV) elevated several hundred-fold. The EBNA1/oriP based plasmid equipped with tumor specific promoter, such as CEA promoter, enabled targeted killing of CEA-positive tumor cell. Transfection of EBNA1/oriP based plasmid carrying IL-12 and IL-18 gene either locally, or systemically, induced therapeufic antitumor immune responses including augmentation of the cytotoxic T lymphocyte and natural killer activities and growth retardation of tumors. For gene therapy of congenital diseases and chronic diseases, the EBNA1/oriP based plasmid encoding the adenosine deaminase gene was transfered into human hematopoietic progenitor cells. The ADA activity was elevated 1.5-to 2-fold. Intracardiomuscrlar transfer of the EBNA1/oriP based plasmid encoding the beta-AR gene may be useful for the treatment of severe heart failure. Human tumor necrosis factoralpha (hTNFalpha) is one of the most important inflammatory cytokines. It has been implicated in many autoimmune and inflammatory diseases. sTNFR can efficiently neutralize the bioactivities of hTNFalpha. In primary study we cloned the chimeric protein sTNFR II-IgG Fc and expect to use it in the gene therapy of the inflammatory disease relative to TNF. In summary, The EBNA1/oriP based plasmid shows advantage in gene therapy of cancer, congenital and inflammatory diseases. Moreover, the EBNA1/oriP element may greatly contribute to the engineering of a human artificial chromosome, the ultimate device for controllable gene therapy. PMID:16108385

  4. A profile of prognostic and molecular factors in European and Māori breast cancer patients

    PubMed Central

    2010-01-01

    Background New Zealand Māori have a poorer outcome from breast cancer than non-Māori, yet prognostic data are sparse. The objective of this study was to quantify levels of prognostic factors in a cohort of self-declared Māori and European breast cancer patients from Christchurch, New Zealand. Methods and Results Clinicopathological and survival data from 337 consecutive breast cancer patients (27 Māori, 310 European) were evaluated. Fewer tumours were high grade in Māori women than European women (p = 0.027). No significant ethnic differences were detected for node status, tumour type, tumour size, human epidermal growth factor receptor, oestrogen and progesterone receptor (ER/PR) status, or survival. In addition, tumour and serum samples from a sub-cohort of 14 Māori matched to 14 NZ European patients were analyzed by immunohistochemistry and enzyme linked immunosorbent assay for molecular prognostic factors. Significant correlations were detected between increased grade and increased levels of hypoxia inducible factor-1 (HIF-1α), glucose transporter-1 (GLUT-1), microvessel density (MVD) and cytokeratins CK5/6 (p < 0.05). High nodal status correlated with reduced carbonic anhydrase IX (CA-IX). Negative ER/PR status correlated with increased GLUT-1, CA-IX and MVD. Within the molecular factors, increased HIF-1α correlated with raised GLUT-1, MVD and CK5/6, and CK5/6 with GLUT-1 and MVD (p < 0.05). The small number of patients in this sub-cohort limited discrimination of ethnic differences. Conclusions In this Christchurch cohort of breast cancer patients, Māori women were no more likely than European women to have pathological or molecular factors predictive of poor prognosis. These data contrast with data from the North Island NZ, and suggest potential regional differences. PMID:20932344

  5. Orbital and Physical Properties of the ? Ori Aa, Ab, B Triple System

    NASA Astrophysics Data System (ADS)

    Simn-Daz, S.; Caballero, J. A.; Lorenzo, J.; Maz Apellniz, J.; Schneider, F. R. N.; Negueruela, I.; Barb, R. H.; Dorda, R.; Marco, A.; Montes, D.; Pellerin, A.; Sanchez-Bermudez, J.; Sdor, .; Sota, A.

    2015-02-01

    We provide a complete characterization of the astrophysical properties of the ? Ori Aa, Ab, B hierarchical triple system and an improved set of orbital parameters for the highly eccentric ? Ori Aa, Ab spectroscopic binary. We compiled a spectroscopic data set comprising 90 high-resolution spectra covering a total time span of 1963 days. We applied the Lehman-Filhs method for a detailed orbital analysis of the radial velocity curves and performed a combined quantitative spectroscopic analysis of the ? Ori Aa, Ab, B system by means of the stellar atmosphere code FASTWIND. We used our own plus other available information on photometry and distance to the system for measuring the radii, luminosities, and spectroscopic masses of the three components. We also inferred evolutionary masses and stellar ages using the Bayesian code BONNSAI. The orbital analysis of the new radial velocity curves led to a very accurate orbital solution of the ? Ori Aa, Ab pair. We provided indirect arguments indicating that ? Ori B is a fast-rotating early B dwarf. The FASTWIND+BONNSAI analysis showed that the Aa, Ab pair contains the hottest and most massive components of the triple system while ? Ori B is a bit cooler and less massive. The derived stellar ages of the inner pair are intriguingly younger than the one widely accepted for the ? Orionis cluster, at 3 1 Ma. The outcome of this study will be of key importance for a precise determination of the distance to the ? Orionis cluster, the interpretation of the strong X-ray emission detected for ? Ori Aa, Ab, B, and the investigation of the formation and evolution of multiple massive stellar systems and substellar objects.

  6. ORBITAL AND PHYSICAL PROPERTIES OF THE σ Ori Aa, Ab, B TRIPLE SYSTEM

    SciTech Connect

    Simón-Díaz, S.; Caballero, J. A.; Apellániz, J. Maíz; Lorenzo, J.; Negueruela, I.; Dorda, R.; Marco, A.; Schneider, F. R. N.; Barbá, R. H.; Montes, D.; Pellerin, A.; Sanchez-Bermudez, J.; Sota, A.

    2015-02-01

    We provide a complete characterization of the astrophysical properties of the σ Ori Aa, Ab, B hierarchical triple system and an improved set of orbital parameters for the highly eccentric σ Ori Aa, Ab spectroscopic binary. We compiled a spectroscopic data set comprising 90 high-resolution spectra covering a total time span of 1963 days. We applied the Lehman-Filhés method for a detailed orbital analysis of the radial velocity curves and performed a combined quantitative spectroscopic analysis of the σ Ori Aa, Ab, B system by means of the stellar atmosphere code FASTWIND. We used our own plus other available information on photometry and distance to the system for measuring the radii, luminosities, and spectroscopic masses of the three components. We also inferred evolutionary masses and stellar ages using the Bayesian code BONNSAI. The orbital analysis of the new radial velocity curves led to a very accurate orbital solution of the σ Ori Aa, Ab pair. We provided indirect arguments indicating that σ Ori B is a fast-rotating early B dwarf. The FASTWIND+BONNSAI analysis showed that the Aa, Ab pair contains the hottest and most massive components of the triple system while σ Ori B is a bit cooler and less massive. The derived stellar ages of the inner pair are intriguingly younger than the one widely accepted for the σ Orionis cluster, at 3 ± 1 Ma. The outcome of this study will be of key importance for a precise determination of the distance to the σ Orionis cluster, the interpretation of the strong X-ray emission detected for σ Ori Aa, Ab, B, and the investigation of the formation and evolution of multiple massive stellar systems and substellar objects.

  7. oriC-encoded instructions for the initiation of bacterial chromosome replication

    PubMed Central

    Wolański, Marcin; Donczew, Rafał; Zawilak-Pawlik, Anna; Zakrzewska-Czerwińska, Jolanta

    2014-01-01

    Replication of the bacterial chromosome initiates at a single origin of replication that is called oriC. This occurs via the concerted action of numerous proteins, including DnaA, which acts as an initiator. The origin sequences vary across species, but all bacterial oriCs contain the information necessary to guide assembly of the DnaA protein complex at oriC, triggering the unwinding of DNA and the beginning of replication. The requisite information is encoded in the unique arrangement of specific sequences called DnaA boxes, which form a framework for DnaA binding and assembly. Other crucial sequences of bacterial origin include DNA unwinding element (DUE, which designates the site at which oriC melts under the influence of DnaA) and binding sites for additional proteins that positively or negatively regulate the initiation process. In this review, we summarize our current knowledge and understanding of the information encoded in bacterial origins of chromosomal replication, particularly in the context of replication initiation and its regulation. We show that oriC encoded instructions allow not only for initiation but also for precise regulation of replication initiation and coordination of chromosomal replication with the cell cycle (also in response to environmental signals). We focus on Escherichia coli, and then expand our discussion to include several other microorganisms in which additional regulatory proteins have been recently shown to be involved in coordinating replication initiation to other cellular processes (e.g., Bacillus, Caulobacter, Helicobacter, Mycobacterium, and Streptomyces). We discuss diversity of bacterial oriC regions with the main focus on roles of individual DNA recognition sequences at oriC in binding the initiator and regulatory proteins as well as the overall impact of these proteins on the formation of initiation complex. PMID:25610430

  8. Co-firing of levator palpebrae and masseter muscles links the masticatory and oculomotor system in humans

    PubMed Central

    Liang, Houcheng; Song, Jinxin; Shen, Di; Qiao, Ying; Zhang, Jingdong

    2015-01-01

    Abstract Simultaneous co-firing of the levator palpebrae (LP) and pterygoid muscles were recorded in Marcus Gann Syndrome (MGS) patients in early clinical studies. Release hypothesis proposed an intrinsic masticatory oculomotor neural circuit and this kind circuit, which, however, has been observed only in amphibian. On the other hand, congenital miswiring hypothesis has overwhelmed other interpretations. However, the same phenomenon visualized in MGS cases was unveiled in human subjects without any sign of congenital oculomotor disorder. To further study co-firing of the upper eyelid and jaw muscles, we applied non-invasive EMG recording of the upper eyelid and ipsilateral masseter muscle belly in nine healthy volunteers. LP activity was determined initially by looking upward and active retraction of upper eyelid with head fixed. Then, dual channel inputs from upper eyelid and masseter muscle was recorded during tooth occlusion motivated by isometric masseter muscle contraction without jaw and face moving. The EMG recorded from upper eyelid when the subjects retracted eyelid with head fixed exhibited the same pattern as that collected during tooth occlusion, but the pattern was completely different from EMG of active eye closure. This reflects tooth occlusion evoked LP activity. Then, simultaneous co-firing of the LP and masseter muscle was recorded simultaneously during tooth occlusion without jaw movement. Finally, the aforementioned co-firing was recorded when the subjects conducted rhythmic occlusion and synchronous EMG from both muscles was acquired. In conclusions, humans may also have an intrinsic masticatory oculomotor circuit and release hypothesis may apply, at least, to some cases of MGS. PMID:26243518

  9. Evaluation of the levator veli palatini muscle thickness in patients with velocardiofacial syndrome using magnetic resonance imaging.

    PubMed

    Park, Mikyong; Ahn, Seung Hyun; Jeong, Jae Hoon; Baek, Rong-Min

    2015-08-01

    Velocardiofacial syndrome (VCFS) is associated with velopharyngeal insufficiency, which occurs in approximately 75% of VCFS patients. Surgical management of velopharyngeal insufficiency in VCFS patients is difficult with a high revision rate due to the anatomic and physiological abnormalities of the velopharynx. The aims of this study were to evaluate the thickness and symmetry of the levator veli palatini (LVP) muscle using magnetic resonance imaging (MRI), and to compare the findings in VCFS patients to those in patients with nonsyndromic submucous cleft palate. We conducted a prospective analysis of 17 VCFS patients (nine boys, eight girls; age range, 4-9 years) and nine patients with submucous cleft palate without VCFS (eight boys, one girl; age range, 4-13 years) who had undergone MRI between March 2009 and August 2013. The thickness of the LVP muscle was measured at six locations in both groups. The symmetry was determined by comparing the values between the average of the left three points and the right three points. The mean LVP muscle thickness was significantly thinner in VCFS patients (2.14 0.73 mm) than in patients without VCFS (3.70 1.08 mm) (p < 0.001). In addition, the difference between the left and right sides of muscle thickness in the VCFS group was larger than that in the nonsyndromic submucous cleft palate group (0.25 and 0.09 mm, respectively). The thinness and asymmetry of the LVP muscle should be considered when determining the surgical management of velopharyngeal insufficiency in VCFS patients. PMID:26031215

  10. Predicting Birth-Related Levator Ani Tear Severity in Primiparous Women: Evaluating Maternal Recovery from Labor and Delivery (EMRLD Study)

    PubMed Central

    Low, Lisa Kane; Zielinski, Ruth; Tao, Yebin; Galecki, Andrzej; Brandon, Catherine J.; Miller, Janis M.

    2014-01-01

    Objective To determine which maternal characteristics or birth events independently predict severity of levator ani muscle (LA) tears at first vaginal birth in a longitudinal/observational investigation in a tertiary care hospital. Sample Ninety primiparas with at least one at risk for LA tear inclusion factor at vaginal birth: maternal age ? 33 years, second stage ? 150 minutes, macrosomia, instrumented delivery, and/or anal sphincter laceration were studied. Methods Magnetic Resonance Imaging (MRI) was obtained early postpartum (mean sd 48.9 21.6 days) to identify LA tear. Severity of LA muscle fiber loss was graded on an ordinal scale of: 0 as no loss, 1 as <50% unilateral loss, 2 as ?50% unilateral or <50% bilateral loss, and 3 as ?50% bilateral loss. Data were analyzed using proportional odds modeling. Inclusion factors were explored as predictors of LA tear severity and at analysis episiotomy, time spent actively pushing, epidural, and oxytocin were also considered. The main outcome measures of interest included grading of severity of LA muscle fiber loss on an ordinal scale. Results Respective counts/percentages of women within each 0 thru 3 ordered category of LA tear severity were: 0 = 58(64%), 1 = 9(10%), 2 = 15(17%), and 3 = 8(9%). Estimates and 95% CI for significant demographic or obstetric univariate predictors of LA tear severity level were age, OR 1.093 (CI 1.012 - 1.180), p = 0.023; and time spent in active pushing, OR 1.089 (CI 1.005 - 1.180), p = 0.038. The other factors considered were not significant. There were too few women with forceps deliveries to analyze. Conclusion: In our enriched sample of primiparous women, 26% showed a significant LA tear. Maternal age and time spent actively pushing independently predict LA tear severity. PMID:25379356

  11. Co-firing of levator palpebrae and masseter muscles links the masticatory and oculomotor system in humans.

    PubMed

    Liang, Houcheng; Song, Jinxin; Shen, Di; Qiao, Ying; Zhang, Jingdong

    2015-07-01

    Simultaneous co-firing of the levator palpebrae (LP) and pterygoid muscles were recorded in Marcus Gann Syndrome (MGS) patients in early clinical studies. "Release hypothesis" proposed an intrinsic masticatory oculomotor neural circuit and this kind circuit, which, however, has been observed only in amphibian. On the other hand, congenital miswiring hypothesis has overwhelmed other interpretations. However, the same phenomenon visualized in MGS cases was unveiled in human subjects without any sign of congenital oculomotor disorder. To further study co-firing of the upper eyelid and jaw muscles, we applied non-invasive EMG recording of the upper eyelid and ipsilateral masseter muscle belly in nine healthy volunteers. LP activity was determined initially by looking upward and active retraction of upper eyelid with head fixed. Then, dual channel inputs from upper eyelid and masseter muscle was recorded during tooth occlusion motivated by isometric masseter muscle contraction without jaw and face moving. The EMG recorded from upper eyelid when the subjects retracted eyelid with head fixed exhibited the same pattern as that collected during tooth occlusion, but the pattern was completely different from EMG of active eye closure. This reflects tooth occlusion evoked LP activity. Then, simultaneous co-firing of the LP and masseter muscle was recorded simultaneously during tooth occlusion without jaw movement. Finally, the aforementioned co-firing was recorded when the subjects conducted rhythmic occlusion and synchronous EMG from both muscles was acquired. In conclusions, humans may also have an intrinsic masticatory oculomotor circuit and release hypothesis may apply, at least, to some cases of MGS. PMID:26243518

  12. Transcripts within the replication origin, oriC, of Escherichia coli.

    PubMed Central

    Schauzu, M A; Kücherer, C; Kölling, R; Messer, W; Lother, H

    1987-01-01

    Transcription start and termination sites were mapped in the E. coli replication origin, oriC. Outward transcription from within oriC (promoters Pori-r and Pori-l) was found to start in vivo at position 178 for Pori-l and at positions 294 and 304 for Pori-r, respectively. These transcripts were terminated after 100-150 bases, at terminators designated Tori-l and Tori-r. Transcription from the 16 kd promoter, which lies clockwise adjacent to oriC and promotes transcription toward oriC, started at position 757 and gave transcripts with 3' ends at several positions within and to the left of the minimal replication origin. However, the majority of transcripts traversed the whole oriC region, and were not terminated within the DNA segment tested. Transcription of the chromosomal 16 kd gene was negatively regulated by DnaA protein and positively affected by dam methylation. The possible function of these transcripts is discussed. Images PMID:3031600

  13. A Star-forming Ring around κ Ori 250 pc from the Sun

    NASA Astrophysics Data System (ADS)

    Pillitteri, I.; Wolk, S. J.; Megeath, S. T.

    2016-04-01

    X-rays are a powerful probe of activity in early stages of star formation. They allow us to identify young stars even after they have lost the IR signatures of circumstellar disks and provide constraints on their distance. Here, we report on XMM-Newton observations that detect 121 young stellar objects (YSOs) in two fields between L1641 S and κ Ori. These observations extend the Survey of Orion A with XMM and Spitzer (SOXS). The YSOs are contained in a ring of gas and dust apparent at millimeter wavelengths, and in far-IR and near-IR surveys. The X-ray luminosity function of the YSOs detected in the two fields indicates a distance of 250–280 pc, much closer than the Orion A cloud and similar to distance estimates of κ Ori. We propose that the ring is a 5–8 pc diameter shell that has been swept up by κ Ori. This ring contains several groups of stars detected by Spitzer and WISE including one surrounding the Herbig Ae/Be stars V1818 Ori. In this interpretation, the κ Ori ring is one of several shells swept up by massive stars within the Orion Eridanus Superbubble and is unrelated to the southern portion of Orion A/L1641 S.

  14. Outcomes of vaginal hysterectomy and constricting colporrhaphy with concurrent levator myorrhaphy and high perineorrhaphy in women older than 75 years of age

    PubMed Central

    Töz, Emrah; Özcan, Aykut; Apaydın, Nesin; Uyar, İbrahim; Kocakaya, Betül; Okay, Gülin

    2015-01-01

    Objectives We performed constricting anterior and posterior colporrhaphy, levator myorrhaphy, and high perineorrhaphy with concurrent hysterectomy, and investigated the intraoperative complications, and short-term outcomes of these constricting procedures in patients aged 75 years or older. Methods We searched our hospital database for cases, between January 2011 and January 2014, of women aged over 75 years who underwent surgery for pelvic organ prolapse of stage 2 or higher, via vaginal hysterectomy, constricting anterior and posterior colporrhaphy, levator myorrhaphy, and high perineorrhaphy, with or without treatment of urinary incontinence. All volunteers were evaluated via pelvic examination using the pelvic organ prolapse quantification system, the modified Decision Regret Scale–Pelvic Floor Disorders form, the Satisfaction Decision Scale–Pelvic Floor Disorders form, and the Pelvic Floor Distress Inventory form. Results Fifty-four patients were included in the study. The mean follow-up time was 24.4 months after constricting surgery (range: 8–44 months). There were four cases (7%) of de novo urge incontinence (the symptoms resolved upon prescription of anticholinergic medication). Two patients developed de novo stress urinary incontinence after the procedure and were treated via transobturator sling surgery using Safyre T® polypropylene monofilament slings. No anatomical or subjective recurrence of prolapse was noted during the follow-up period. No patient required additional surgery for recurrence of prolapse. Conclusion Constricting anterior and posterior colporrhaphy, levator myorrhaphy, and high perineorrhaphy with concurrent hysterectomy is a feasible, safe, and effective surgical option in elderly patients at low anesthesiological risk. The decision to perform an incontinence procedure should be individualized based on preoperative findings after prolapse reduction. PMID:26150705

  15. Looking M?ori predicts decreased rates of home ownership: institutional racism in housing based on perceived appearance.

    PubMed

    Houkamau, Carla A; Sibley, Chris G

    2015-01-01

    This study examined differences in rates of home ownership among M?ori (the indigenous peoples of New Zealand). We identified systematic factors that predicted why some M?ori were more likely to own their own home (partially or fully) relative to other M?ori. Data were drawn from a large national postal sample of 561 self-identified M?ori collected as part of the New Zealand Attitudes and Values Study. As predicted, our analyses indicated that self-reported appearance as M?ori, or the extent to which people thought they personally displayed features which visibly identified them as M?ori to others, significantly predicted decreased rates of home ownership. This association held when adjusting for numerous demographic covariates, such as education, level of deprivation of the immediate area, household income, age, relationship status, region of residence, and so forth. Our analyses suggest there is, or at least has been in the recent past, institutional racism against M?ori in New Zealand's home lending industry based on merely appearing more M?ori. PMID:25738961

  16. 78 FR 49507 - OriGen Energy LLC ; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission OriGen Energy LLC ; Supplemental Notice That Initial Market-Based Rate...-referenced proceeding of OriGen Energy LLC's application for market-based rate authority, with...

  17. The multi-dimensional model of M?ori identity and cultural engagement: item response theory analysis of scale properties.

    PubMed

    Sibley, Chris G; Houkamau, Carla A

    2013-01-01

    We argue that there is a need for culture-specific measures of identity that delineate the factors that most make sense for specific cultural groups. One such measure, recently developed specifically for M?ori peoples, is the Multi-Dimensional Model of M?ori Identity and Cultural Engagement (MMM-ICE). M?ori are the indigenous peoples of New Zealand. The MMM-ICE is a 6-factor measure that assesses the following aspects of identity and cultural engagement as M?ori: (a) group membership evaluation, (b) socio-political consciousness, (c) cultural efficacy and active identity engagement, (d) spirituality, (e) interdependent self-concept, and (f) authenticity beliefs. This article examines the scale properties of the MMM-ICE using item response theory (IRT) analysis in a sample of 492 M?ori. The MMM-ICE subscales showed reasonably even levels of measurement precision across the latent trait range. Analysis of age (cohort) effects further indicated that most aspects of M?ori identification tended to be higher among older M?ori, and these cohort effects were similar for both men and women. This study provides novel support for the reliability and measurement precision of the MMM-ICE. The study also provides a first step in exploring change and stability in M?ori identity across the life span. A copy of the scale, along with recommendations for scale scoring, is included. PMID:23356361

  18. Thermal imaging of the FU Ori type object 2MASS J06593158-0405277 = V960 Mon

    NASA Astrophysics Data System (ADS)

    Varricatt, W. P.; Kerr, T. H.; Carroll, T.; Moore, E.; Milne, P.

    2015-10-01

    A FU Ori-type outburst of 2MASS J06593158-0405277 (V960 Mon) was discovered by Maehara, Kojima and Fujii (ATel #6770). Further observational studies (ATel #6797, #6838, #6862, #6901, #7025, #7578) and archival data research (Jurdana- & #138;epi & #263; & Munari, 2016, NewA, 43, 87) confirmed the FU Ori nature of this object.

  19. Looking Māori Predicts Decreased Rates of Home Ownership: Institutional Racism in Housing Based on Perceived Appearance

    PubMed Central

    2015-01-01

    This study examined differences in rates of home ownership among Māori (the indigenous peoples of New Zealand). We identified systematic factors that predicted why some Māori were more likely to own their own home (partially or fully) relative to other Māori. Data were drawn from a large national postal sample of 561 self-identified Māori collected as part of the New Zealand Attitudes and Values Study. As predicted, our analyses indicated that self-reported appearance as Māori, or the extent to which people thought they personally displayed features which visibly identified them as Māori to others, significantly predicted decreased rates of home ownership. This association held when adjusting for numerous demographic covariates, such as education, level of deprivation of the immediate area, household income, age, relationship status, region of residence, and so forth. Our analyses suggest there is, or at least has been in the recent past, institutional racism against Māori in New Zealand’s home lending industry based on merely appearing more Māori. PMID:25738961

  20. Otariodibacter oris and Bisgaardia genomospecies 1 isolated from infections in pinnipeds.

    PubMed

    Hansen, Mie Johanne; Bertelsen, Mads Frost; Delaney, Martha Ann; Fravel, Vanessa Ashley; Gulland, Frances; Bojesen, Anders Miki

    2013-07-01

    We document the first associations of two recently described species of Pasteurellaceae bacteria with lesions in wild pinnipeds in rehabilitation. Samples were collected from nine lesions in four California sea lions (Zalophus californianus) and two Pacific harbor seals (Phoca vitulina) during necropsy or admission examinations at a rehabilitation facility in northern California. Seven Pasteurellaceae isolates were identified using phenotypic tests and partial rpoB gene sequencing. Six strains of Otariodibacter oris were isolated from California sea lions. Otariodibacter oris was isolated in pure culture from four abscesses, an affected lymph node, and a bone lesion consistent with osteomyelitis. Otariodibacter oris was also cultured with Arcanobacterium phocae and β-hemolytic streptococci. A pure culture of Bisgaardia genomospecies 1 was obtained from an abscess in a harbor seal. This is the first time, to our knowledge, that O. oris has been associated with infection. Isolation of these bacteria in pure culture from abscesses and osteomyelitis strongly indicates a pathogenic potential of this organism. Likewise, the isolation of Bisgaardia genomospecies 1 in pure culture from an abscess in a harbor seal implies causality. PMID:23778617

  1. FU Ori-type outburst of 2MASS J06593158-0405277

    NASA Astrophysics Data System (ADS)

    Maehara, Hiroyuki; Kojima, Tadashi; Fujii, Mitsugu

    2014-11-01

    We report the discovery of an FU Ori-type outburst of 2MASS J06593158-0405277. The outburst was discovered by T. Kojima from the survey image obtained with a 85mm f/2.8 lens and Canon EOS 60D DSLR camera on 2014-11-03.821 UT at mag 11.0.

  2. Swift and SMARTS observations of the 2015 outburst of V1118 Ori

    NASA Astrophysics Data System (ADS)

    Audard, Marc; Hamaguchi, Kenji; Kastner, Joel; Grosso, Nicolas; Walter, Frederick M.

    2016-01-01

    Swift observed V1118 Ori on 2015 Dec 11-12 (5.17 ksec, obs ID 00034203001) and on Dec 16 (2.45ks, obs ID 00034203002) during the latest mass accretion outburst reported by Lorenzetti et al. (ATel #8100).

  3. Observing the Circumstellar Environment of the Eruptive FUor/EXor Protostar V1647 Ori with ALMA

    NASA Astrophysics Data System (ADS)

    Principe, David; Cieza, Lucas A.; Zhu, Zhaohuan; Tobin, John J.; Prieto, Jose Luis

    2016-01-01

    Fu Ori (FUor) and EXor objects represent a short-lived stage of protostellar evolution characterized by intense mass accretion events which cause extreme variability in the form of outbursts. While it is well demonstrated that these objects exhibit sudden outbursts (ΔV~2-6), the mechanism causing such variability is not well understood. High spatial and spectral resolution observations of the circumstellar environment of these objects are essential to distinguish between different outbursting mechanisms. We present ALMA observations of the FUor/EXor object V1647 Ori as part of an ALMA campaign, which has observed a combined eight FUor and EXor type objects. Deeply embedded in the dark cloud LDN 1630 (L1630), V1647 Ori is one of a few FUor/EXor objects to have been extensively studied at multiple wavelengths before, during and after an outburst. We present preliminary results derived from ALMA 12CO, 13CO, C18O and continuum observations of the circumstellar environment of V1647 Ori. By measuring gas/dust masses and gas kinematics of the circumstellar disk, we investigate the potential mechanisms producing variability in these eruptive protostars during an essential, yet rarely observed, stage of pre-main sequence stellar evolution.

  4. A Long-lasting Quiescence Phase of the Eruptive Variable V1118 Ori

    NASA Astrophysics Data System (ADS)

    Lorenzetti, D.; Antoniucci, S.; Giannini, T.; Harutyunyan, A.; Arkharov, A. A.; Larionov, V. M.; Cusano, F.; Di Paola, A.; Li Causi, G.; Nisini, B.; Speziali, R.; Vitali, F.

    2015-03-01

    V1118 Ori is an eruptive variable belonging to the EXor class of pre-main-sequence stars whose episodic outbursts are attributed to disk accretion events. Since 2006, V1118 Ori has been in the longest quiescence stage ever observed between two subsequent outbursts in its recent history. We present near-infrared photometry of V1118 Ori carried out over the last eight years, along with complete spectroscopic coverage from 0.35 to 2.5 μm. Long term sampling of V1118 Ori in quiescence has never been performed, and hence we can benefit from the current circumstance by determining the lowest values (i.e., the zeroes) of the parameters to be used as reference for evaluating the physical changes typical of more active phases. A quiescence mass accretion rate of 1-3 × 10-9 {{M}} yr-1 can be derived and the difference from previous determinations is discussed. Based on line emission and IR color analysis, a visual extinction of 1-2 mag is consistently derived, confirming that V1118 Ori (at least in quiescence) is a low-extinction T Tauri star with a bolometric luminosity of about 2.1 {{L}}. An anti-correlation exists between the equivalent width of the emission lines and the underlying continuum. We searched the literature to evaluate whether or not such behavior is a common feature for the whole class. The anti-correlation is clearly recognizable for all of the available EXors in the optical range (Hβ and Hα lines); however, this is not as evident in the infrared (Paβ and Brγ lines). The observed anti-correlation supports the accretion-driven mechanism as the most likely to account for continuum variations.

  5. Initiation of Heat-Induced Replication Requires DnaA and the L-13-mer of oriC▿

    PubMed Central

    González-Soltero, Rocío; Botello, Emilia; Jiménez-Sánchez, Alfonso

    2006-01-01

    An upshift of 10°C or more in the growth temperature of an Escherichia coli culture causes induction of extra rounds of chromosome replication. This stress replication initiates at oriC but has functional requirements different from those of cyclic replication. We named this phenomenon heat-induced replication (HIR). Analysis of HIR in bacterial strains that had complete or partial oriC deletions and were suppressed by F integration showed that no sequence outside oriC is used for HIR. Analysis of a number of oriC mutants showed that deletion of the L-13-mer, which makes oriC inactive for cyclic replication, was the only mutation studied that inactivated HIR. The requirement for this sequence was strictly correlated with Benham's theoretical stress-induced DNA duplex destabilization. oriC mutations at DnaA, FIS, or IHF binding sites showed normal HIR activation, but DnaA was required for HIR. We suggest that strand opening for HIR initiation occurs due to heat-induced destabilization of the L-13-mer, and the stable oligomeric DnaA-single-stranded oriC complex might be required only to load the replicative helicase DnaB. PMID:16980453

  6. Initiation of heat-induced replication requires DnaA and the L-13-mer of oriC.

    PubMed

    González-Soltero, Rocío; Botello, Emilia; Jiménez-Sánchez, Alfonso

    2006-12-01

    An upshift of 10 degrees C or more in the growth temperature of an Escherichia coli culture causes induction of extra rounds of chromosome replication. This stress replication initiates at oriC but has functional requirements different from those of cyclic replication. We named this phenomenon heat-induced replication (HIR). Analysis of HIR in bacterial strains that had complete or partial oriC deletions and were suppressed by F integration showed that no sequence outside oriC is used for HIR. Analysis of a number of oriC mutants showed that deletion of the L-13-mer, which makes oriC inactive for cyclic replication, was the only mutation studied that inactivated HIR. The requirement for this sequence was strictly correlated with Benham's theoretical stress-induced DNA duplex destabilization. oriC mutations at DnaA, FIS, or IHF binding sites showed normal HIR activation, but DnaA was required for HIR. We suggest that strand opening for HIR initiation occurs due to heat-induced destabilization of the L-13-mer, and the stable oligomeric DnaA-single-stranded oriC complex might be required only to load the replicative helicase DnaB. PMID:16980453

  7. Climate change and the right to health for M?ori in Aotearoa/New Zealand.

    PubMed

    Jones, Rhys; Bennett, Hayley; Keating, Gay; Blaiklock, Alison

    2014-01-01

    Climate change is widely regarded as one of the most serious global health threats of the 21st century. Its impacts will be disproportionately borne by the most disadvantaged populations, including indigenous peoples. For M?ori in Aotearoa/New Zealand, as with other indigenous peoples worldwide, colonization has led to dispossession of land, destabilization of cultural foundations, and social, economic, and political marginalization. Climate change threatens to exacerbate these processes, adding future insult to historical and contemporary injury. Yet the challenges posed by climate change are accompanied by considerable opportunities to advance indigenous rights and reduce health disparities. In this paper, we examine issues related to climate change and M?ori health using a right to health analytical framework, which identifies obligations for the New Zealand government. PMID:25474611

  8. MOST OBSERVATIONS OF {sigma} Ori E: CHALLENGING THE CENTRIFUGAL BREAKOUT NARRATIVE

    SciTech Connect

    Townsend, R. H. D.; Rivinius, Th.; Rowe, J. F.; Moffat, A. F. J.; Matthews, J. M.; Kallinger, T.; Kuschnig, R.; Bohlender, D.; Neiner, C.; Telting, J. H.; Guenther, D. B.; Rucinski, S. M.; Sasselov, D.; Weiss, W. W.

    2013-05-20

    We present results from three weeks' photometric monitoring of the magnetic helium-strong star {sigma} Ori E using the Microvariability and Oscillations of Stars microsatellite. The star's light curve is dominated by twice-per-rotation eclipse-like dimmings arising when magnetospheric clouds transit across and occult the stellar disk. However, no evidence is found for any abrupt centrifugal breakout of plasma from the magnetosphere, either in the residual flux or in the depths of the light minima. Motivated by this finding we compare the observationally inferred magnetospheric mass against that predicted by a breakout analysis. The large discrepancy between the values leads us to argue that centrifugal breakout does not play a significant role in establishing the magnetospheric mass budget of {sigma} Ori E.

  9. The Dynamical Future of the Mini-cluster θ1 Ori B

    NASA Astrophysics Data System (ADS)

    Allen, Christine; Costero, Rafael; Hernández, Miroslava

    2015-12-01

    Recent adaptive optics observations have shown that θ1 Ori B is a mini-cluster composed of five stars, and that it is probably bound. The dynamical stability of such a system is, however, questionable. By means of N-body integrations we conduct an exploratory study of the dynamical fate of an ensemble of systems closely resembling θ1 Ori B in projection, with random positions and velocities in the z-direction, and with perturbations compatible with observational errors in the plane. We find that the great majority of the systems are destroyed after 100 crossing times (about 30,000 years). Even after only five crossing times, 20% of the systems dissolve, leaving behind only a tight binary. The implications of these results for the probable age of this multiple system, the fate of stars formed in small clusters, the formation of low mass runaway stars, and the properties of visual binaries are discussed.

  10. X-Ray Production by V1647 Ori During Optical Outbursts

    NASA Technical Reports Server (NTRS)

    Teets, William; Weintraub, David; Grosso, Nicolas; Principe, David; Kastner, Joel; Hamaguchi, Kenji; Richmond, Michael

    2011-01-01

    The pre-main-sequence (PMS) star V1647 Ori has recently undergone two optical/near-infrared (OIR) outbursts that are associated with dramatic enhancements in the stellar accretion rate. Our intensive X-ray monitoring of this object affords the opportunity to investigate whether and how the intense X-ray emission is related to PMS accretion activity. Our analysis of all 14 Chandra X-Ray Observatory observations of V1647 Ori demonstrates that variations in the X-ray luminosity of V1647 Ori are correlated with similar changes in the OIR brightness of this source during both (2003-2005 and 2008) eruptions, strongly supporting the hypothesis that accretion is the primary generation mechanism for the X-ray outbursts. Furthermore, the Chandra monitoring demonstrates that the X-ray spectral properties of the second eruption were strikingly similar to those of the 2003 eruption. We find that X-ray spectra obtained immediately following the second outburstduring which V1647 Ori exhibited high X-ray luminosities, high hardness ratios, and strong X-ray variabilityare well modeled as a heavily absorbed (N H 4 1022cm2), single-component plasma with characteristic temperatures (kT X 2-6keV) that are consistently too high to be generated via accretion shocks but are in the range expected for plasma heated by magnetic reconnection events. We also find that the X-ray absorbing column has not changed significantly throughout the observing campaign. Since the OIR and X-ray changes are correlated, we hypothesize that these reconnection events either occur in the accretion stream connecting the circumstellar disk to the star or in accretion-enhanced protostellar coronal activity.

  11. X-Ray Production by V1647 Ori during Optical Outbursts

    NASA Astrophysics Data System (ADS)

    Teets, William K.; Weintraub, David A.; Grosso, Nicolas; Principe, David; Kastner, Joel H.; Hamaguchi, Kenji; Richmond, Michael

    2011-11-01

    The pre-main-sequence (PMS) star V1647 Ori has recently undergone two optical/near-infrared (OIR) outbursts that are associated with dramatic enhancements in the stellar accretion rate. Our intensive X-ray monitoring of this object affords the opportunity to investigate whether and how the intense X-ray emission is related to PMS accretion activity. Our analysis of all 14 Chandra X-Ray Observatory observations of V1647 Ori demonstrates that variations in the X-ray luminosity of V1647 Ori are correlated with similar changes in the OIR brightness of this source during both (2003-2005 and 2008) eruptions, strongly supporting the hypothesis that accretion is the primary generation mechanism for the X-ray outbursts. Furthermore, the Chandra monitoring demonstrates that the X-ray spectral properties of the second eruption were strikingly similar to those of the 2003 eruption. We find that X-ray spectra obtained immediately following the second outburstduring which V1647 Ori exhibited high X-ray luminosities, high hardness ratios, and strong X-ray variabilityare well modeled as a heavily absorbed (N H ~ 4 1022 cm-2), single-component plasma with characteristic temperatures (kT X ~ 2-6 keV) that are consistently too high to be generated via accretion shocks but are in the range expected for plasma heated by magnetic reconnection events. We also find that the X-ray absorbing column has not changed significantly throughout the observing campaign. Since the OIR and X-ray changes are correlated, we hypothesize that these reconnection events either occur in the accretion stream connecting the circumstellar disk to the star or in accretion-enhanced protostellar coronal activity.

  12. Reducing smoking in pregnancy among M?ori women: "aunties" perceptions and willingness to help.

    PubMed

    van Esdonk, Tineke; Glover, Marewa; Kira, Anette; Wagemakers, Annemarie

    2014-12-01

    M?ori (the indigenous people of New Zealand) women have high rates of smoking during pregnancy and 42 % register with a lead maternity carer (LMC) after their first trimester, delaying receipt of cessation support. We used a participatory approach with M?ori community health workers ("Aunties") to determine their willingness and perceived ability to find pregnant M?ori smokers early in pregnancy and to provide cessation support. Three meetings were held in three different regions in New Zealand. The aunties believed they could find pregnant women in first trimester who were still smoking by using their networks, the 'kumara-vine' (sweet potato vine), tohu (signs/omens), their instinct and by looking for women in the age range most likely to get pregnant. The aunties were willing to provide cessation and other support but they said they would do it in a "M?ori way" which depended on formed relationships and recognised roles within families. The aunties' believed that their own past experiences with pregnancy and/or smoking would be advantageous when providing support. Aunties' knowledge about existing proven cessation methods and services and knowledge about how to register with a LMC ranged from knowing very little to having years of experience working in the field. They were all supportive of receiving up-to-date information on how best to support pregnant women to stop smoking. Aunties in communities believe that they could find pregnant women who smoke and they are willing to help deliver cessation support. Our ongoing research will test the effectiveness of such an approach. PMID:24214817

  13. Revisiting the Rigidly Rotating Magnetosphere model for σ Ori E - I. Observations and data analysis

    NASA Astrophysics Data System (ADS)

    Oksala, M. E.; Wade, G. A.; Townsend, R. H. D.; Owocki, S. P.; Kochukhov, O.; Neiner, C.; Alecian, E.; Grunhut, J.

    2012-01-01

    We have obtained 18 new high-resolution spectropolarimetric observations of the B2Vp star σ Ori E with both the Narval and ESPaDOnS spectropolarimeters. The aim of these observations is to test, with modern data, the assumptions of the Rigidly Rotating Magnetosphere (RRM) model of Townsend & Owocki, applied to the specific case of σ Ori E by Townsend, Owocki & Groote. This model includes a substantially offset dipole magnetic field configuration, and approximately reproduces previous observational variations in longitudinal field strength, photometric brightness and Hα emission. We analyse new spectroscopy, including H I, He I, C II, Si III and Fe III lines, confirming the diversity of variability in photospheric lines, as well as the double S-wave variation of circumstellar hydrogen. Using the multiline analysis method of least-squares deconvolution (LSD), new, more precise longitudinal magnetic field measurements reveal a substantial variance between the shapes of the observed and RRM model time-varying field. The phase-resolved Stokes V profiles of He I 5876 and 6678 Å lines are fitted poorly by synthetic profiles computed from the magnetic topology assumed by Townsend et al.. These results challenge the offset dipole field configuration assumed in the application of the RRM model to σ Ori E, and indicate that future models of its magnetic field should also include complex, higher order components. Footnotes<label>1</label></p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24648644','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24648644"><span id="translatedtitle">Effect of expiratory resistive loading in expiratory muscle strength training on orbicularis <span class="hlt">oris</span> muscle activity.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Yanagisawa, Yukio; Matsuo, Yoshimi; Shuntoh, Hisato; Horiuchi, Noriaki</p> <p>2014-02-01</p> <p>[Purpose] The purpose of this study was to elucidate the effect of expiratory resistive loading on orbicularis <span class="hlt">oris</span> muscle activity. [Subjects] Subjects were 23 healthy individuals (11 males, mean age 25.54.3?years; 12 females, mean age 25.03.0?years). [Methods] Surface electromyography was performed to measure the activity of the orbicularis <span class="hlt">oris</span> muscle during maximum lip closure and resistive loading at different expiratory pressures. Measurement was performed at 10%, 30%, 50%, and 100% of maximum expiratory pressure (MEP) for all subjects. The t-test was used to compare muscle activity between maximum lip closure and 100% MEP, and analysis of variance followed by multiple comparisons was used to compare the muscle activities observed at different expiratory pressures. [Results] No significant difference in muscle activity was observed between maximum lip closure and 100% MEP. Analysis of variance with multiple comparisons revealed significant differences among the different expiratory pressures. [Conclusion] Orbicularis <span class="hlt">oris</span> muscle activity increased with increasing expiratory resistive loading. PMID:24648644</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3944301','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3944301"><span id="translatedtitle">Effect of Expiratory Resistive Loading in Expiratory Muscle Strength Training on Orbicularis <span class="hlt">Oris</span> Muscle Activity</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Yanagisawa, Yukio; Matsuo, Yoshimi; Shuntoh, Hisato; Horiuchi, Noriaki</p> <p>2014-01-01</p> <p>[Purpose] The purpose of this study was to elucidate the effect of expiratory resistive loading on orbicularis <span class="hlt">oris</span> muscle activity. [Subjects] Subjects were 23 healthy individuals (11 males, mean age 25.54.3?years; 12 females, mean age 25.03.0?years). [Methods] Surface electromyography was performed to measure the activity of the orbicularis <span class="hlt">oris</span> muscle during maximum lip closure and resistive loading at different expiratory pressures. Measurement was performed at 10%, 30%, 50%, and 100% of maximum expiratory pressure (MEP) for all subjects. The t-test was used to compare muscle activity between maximum lip closure and 100% MEP, and analysis of variance followed by multiple comparisons was used to compare the muscle activities observed at different expiratory pressures. [Results] No significant difference in muscle activity was observed between maximum lip closure and 100% MEP. Analysis of variance with multiple comparisons revealed significant differences among the different expiratory pressures. [Conclusion] Orbicularis <span class="hlt">oris</span> muscle activity increased with increasing expiratory resistive loading. PMID:24648644</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26735331','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26735331"><span id="translatedtitle">Neoliberalism and indigenous knowledge: Mā<span class="hlt">ori</span> health research and the cultural politics of New Zealand's "National Science Challenges".</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Prussing, Erica; Newbury, Elizabeth</p> <p>2016-02-01</p> <p>In 2012-13 the Ministry of Business, Innovation and Employment (MBIE) in New Zealand rapidly implemented a major restructuring of national scientific research funding. The "National Science Challenges" (NSC) initiative aims to promote greater commercial applications of scientific knowledge, reflecting ongoing neoliberal reforms in New Zealand. Using the example of health research, we examine the NSC as a key moment in ongoing indigenous Mā<span class="hlt">ori</span> advocacy against neoliberalization. NSC rhetoric and practice through 2013 moved to marginalize participation by Mā<span class="hlt">ori</span> researchers, in part through constructing "Mā<span class="hlt">ori</span>" and "science" as essentially separate arenas-yet at the same time appeared to recognize and value culturally distinctive forms of Mā<span class="hlt">ori</span> knowledge. To contest this "neoliberal multiculturalism," Mā<span class="hlt">ori</span> health researchers reasserted the validity of culturally distinctive knowledge, strategically appropriated NSC rhetoric, and marshalled political resources to protect Mā<span class="hlt">ori</span> research infrastructure. By foregrounding scientific knowledge production as an arena of contestation over neoliberal values and priorities, and attending closely to how neoliberalizing tactics can include moves to acknowledge cultural diversity, this analysis poses new questions for social scientific study of global trends toward reconfiguring the production of knowledge about health. Study findings are drawn from textual analysis of MBIE documents about the NSC from 2012 to 2014, materials circulated by Mā<span class="hlt">ori</span> researchers in the blogosphere in 2014, and ethnographic interviews conducted in 2013 with 17 Mā<span class="hlt">ori</span> health researchers working at 7 sites that included university-based research centers, government agencies, and independent consultancies. PMID:26735331</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=107518','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=107518"><span id="translatedtitle">The Bacteroides fragilis BtgA Mobilization Protein Binds to the <span class="hlt">ori</span>T Region of pBFTM10</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Sitailo, Leonid A.; Zagariya, Alexander M.; Arnold, Patrick J.; Vedantam, Gayatri; Hecht, David W.</p> <p>1998-01-01</p> <p>The Bacteroides fragilis conjugal plasmid pBFTM10 contains two genes, btgA and btgB, and a putative <span class="hlt">ori</span>T region necessary for transfer in Bacteroides fragilis and Escherichia coli. The BtgA protein was predicted to contain a helix-turn-helix motif, indicating possible DNA binding activity. DNA sequence analysis of the region immediately upstream of btgA revealed three sets of inverted repeats, potentially locating the <span class="hlt">ori</span>T region. A 304-bp DNA fragment comprising this putative <span class="hlt">ori</span>T region was cloned and confirmed to be the functional pBFTM10 <span class="hlt">ori</span>T by bacterial conjugation experiments using E. coli and B. fragilis. btgA was cloned and overexpressed in E. coli, and the purified protein was used in electrophoretic mobility shift assays, demonstrating specific binding of BtgA protein to its cognate <span class="hlt">ori</span>T. DNase I footprint analysis demonstrated that BtgA binds apparently in a single-stranded fashion to the <span class="hlt">ori</span>T-containing fragment, overlapping inverted repeats I, II, and III and the putative nick site. PMID:9733696</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23486752','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23486752"><span id="translatedtitle">Narratives of four Mā<span class="hlt">ori</span> ex-inmates about their experiences and perspectives of rehabilitation programmes.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nakhid, Camille; Shorter, Lily Tairiri</p> <p>2014-06-01</p> <p>Mā<span class="hlt">ori</span> are overrepresented in the criminal justice system in Aotearoa New Zealand. Mā<span class="hlt">ori</span> offenders comprise 53% of those serving custodial sentences and 48% serving community-based sentences. The majority of Mā<span class="hlt">ori</span> offenders reoffended within 2 years of serving their sentence. A number of programmes aimed at reducing recidivism among Mā<span class="hlt">ori</span> have been implemented, and there is considerable debate around the effectiveness of these programmes. This qualitative study focuses on the narratives of four Mā<span class="hlt">ori</span> male ex-inmates about their reoffending and their experiences of the rehabilitation programmes during their incarceration. Using a narrative approach, the study sought to hear the shared stories from the men and to determine what they believe would have reduced their reoffending. The stories revealed that a lack of financial resources and gang connections influenced reoffending; the value of prison rehabilitation programmes varied depending on their appropriateness to the inmate and to their intended outcomes; and healing programmes incorporating kaupapa Mā<span class="hlt">ori</span> principles and practices assisted the participants in understanding their cultural heritage and communicating with society in more acceptable ways. PMID:23486752</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=523242','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=523242"><span id="translatedtitle">Human Cytomegalovirus DNA Replication Requires Transcriptional Activation via an IE2- and UL84-Responsive Bidirectional Promoter Element within <span class="hlt">ori</span>Lyt</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Xu, Yiyang; Cei, Sylvia A.; Huete, Alicia Rodriguez; Colletti, Kelly S.; Pari, Gregory S.</p> <p>2004-01-01</p> <p>Amplification of the human cytomegalovirus (HCMV) lytic origin (<span class="hlt">ori</span>Lyt) in human fibroblasts is dependent upon six core replication proteins and UL84, IE2, and UL36-38. Using a telomerase-immortalized human fibroblast cell line (T-HFs), <span class="hlt">ori</span>Lyt-dependent DNA replication no longer required the gene products of UL36-38. To determine the role of IE2 in DNA replication in human fibroblasts, we examined potential IE2-binding sites within HCMV <span class="hlt">ori</span>Lyt. We now show that a strong bidirectional promoter (<span class="hlt">ori</span>LytPM) (nucleotides 91754 to 92030) is located in the previously identified core region of the origin and is required for efficient amplification of <span class="hlt">ori</span>Lyt. It was determined that a 14-bp novel DNA motif (<span class="hlt">ori</span>Lyt promoter activation element), which was initially identified as a binding element for the immediate-early protein IE2, was essential for <span class="hlt">ori</span>LytPM activity. In Vero cells the <span class="hlt">ori</span>LytPM was constitutively active and strongly repressed by IE2, but it was reactivated by UL84. In contrast, transfection of the <span class="hlt">ori</span>LytPM into human fibroblasts resulted in a very low basal level of promoter activity that was dramatically up-regulated upon infection with HCMV. Cotransfection assays demonstrated that the transfection of UL84 along with IE2 transactivated the <span class="hlt">ori</span>LytPM in human fibroblasts. Further activation was observed upon cotransfection of the set of plasmids expressing the entire replication complex. Efficient <span class="hlt">ori</span>Lyt amplification in the absence of IE2 in human fibroblasts was observed by replacing the <span class="hlt">ori</span>LytPM with the simian virus 40 early promoter. Under these conditions, however, UL84 was still required for amplification of <span class="hlt">ori</span>Lyt. These results suggest that the mechanism of initiation of HCMV lytic replication in part involves transcriptional activation. PMID:15479808</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21558445','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21558445"><span id="translatedtitle">Ancient DNA recovers the origins of Mā<span class="hlt">ori</span> feather cloaks.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hartnup, K; Huynen, L; Te Kanawa, R; Shepherd, L D; Millar, C D; Lambert, D M</p> <p>2011-10-01</p> <p>Feather cloaks ("kakahu"), particularly those adorned with kiwi feathers, are treasured items or "taonga" to the Mā<span class="hlt">ori</span> people of "Aotearoa"/New Zealand. They are considered iconic expression of Mā<span class="hlt">ori</span> culture. Despite their status, much of our knowledge of the materials used to construct cloaks, the provenance of cloaks, and the origins of cloak making itself, has been lost. We used ancient DNA methods to recover mitochondrial DNA sequences from 849 feather samples taken from 109 cloaks. We show that almost all (>99%) of the cloaks were constructed using feathers from North Island brown kiwi. Molecular sexing of nuclear DNA recovered from 92 feather cloak samples also revealed that the sex ratio of birds deviated from a ratio of 1:1 observed in reference populations. Additionally, we constructed a database of 185 mitochondrial control region DNA sequences of kiwi feathers comprising samples collected from 26 North Island locations together with data available from the literature. Genetic subdivision (G(ST)), nucleotide subdivision (N(ST)) and Spatial Analysis of Molecular Variants (SAMOVA) analyses revealed high levels of genetic structuring in North Island brown kiwi. Together with sequence data from previously studied ancient and modern kiwi samples, we were able to determine the geographic provenance of 847 cloak feathers from 108 cloaks. A surprising proportion (15%) of cloaks were found to contain feathers from different geographic locations, providing evidence of kiwi trading among Mā<span class="hlt">ori</span> tribes or organized hunting trips into other tribal areas. Our data also suggest that the east of the North Island of New Zealand was the most prolific of all kiwi cloak making areas, with over 50% of all cloaks analyzed originating from this region. Similar molecular approaches have the potential to discover a wealth of lost information from artifacts of endemic cultures worldwide. PMID:21558445</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li class="active"><span>5</span></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_5 --> <div id="page_6" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li class="active"><span>6</span></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="101"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/22273320','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/22273320"><span id="translatedtitle">HH 222: A GIANT HERBIG-HARO FLOW FROM THE QUADRUPLE SYSTEM V380 <span class="hlt">ORI</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Reipurth, Bo; Aspin, Colin; Connelley, M. S.; Bally, John; Geballe, T. R.; Kraus, Stefan; Appenzeller, Immo; Burgasser, Adam E-mail: caa@ifa.hawaii.edu E-mail: John.Bally@colorado.edu E-mail: stefan.kraus@cfa.harvard.edu E-mail: aburgasser@ucsd.edu</p> <p>2013-11-01</p> <p>HH 222 is a giant shocked region in the L1641 cloud, and is popularly known as the Orion Streamers or ''the waterfall'' on account of its unusual structure. At the center of these streamers are two infrared sources coincident with a nonthermal radio jet aligned along the principal streamer. The unique morphology of HH 222 has long been associated with this radio jet. However, new infrared images show that the two sources are distant elliptical galaxies, indicating that the radio jet is merely an improbable line-of-sight coincidence. Accurate proper motion measurements of HH 222 reveal that the shock structure is a giant bow shock moving directly away from the well-known, very young, Herbig Be star V380 <span class="hlt">Ori</span>. The already known Herbig-Haro object HH 35 forms part of this flow. A new Herbig-Haro object, HH 1041, is found precisely in the opposite direction of HH 222 and is likely to form part of a counterflow. The total projected extent of this HH complex is 5.3 pc, making it among the largest HH flows known. A second outflow episode from V380 <span class="hlt">Ori</span> is identified as a pair of HH objects, HH 1031 to the northwest and the already known HH 130 to the southeast, along an axis that deviates from that of HH 222/HH 1041 by only 3.°7. V380 <span class="hlt">Ori</span> is a hierarchical quadruple system, including a faint companion of spectral type M5 or M6, which at an age of ∼1 Myr corresponds to an object straddling the stellar-to-brown dwarf boundary. We suggest that the HH 222 giant bow shock is a direct result of the dynamical interactions that led to the conversion from an initial non-hierarchical multiple system into a hierarchical configuration. This event occurred no more than 28,000 yr ago, as derived from the proper motions of the HH 222 giant bow shock.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013prpl.conf2B025K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013prpl.conf2B025K"><span id="translatedtitle">Revealing the inclined circumstellar disk in the UX <span class="hlt">Ori</span> system KK Ophiuchi</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kreplin, A.; Weigelt, G.; Kraus, S.; Grinin, V.; Hofmann, K.-H.; Kishimoto, M.; Schertl, D.; Tambovtseva, L.; Clausse, J.-M.; Massi, F.; Perraut, K.; Stee, Ph.</p> <p>2013-07-01</p> <p>We study the inner sub-AU region of the circumstellar environment of the UX <span class="hlt">Ori</span> type star KK Oph with near-infrared VLTI/AMBER interferometry. We are particularly interested in the inclination of the star-disk system, and we will use this information to test the current standard picture for UX <span class="hlt">Ori</span> stars. We recorded spectrally dispersed (R˜35) interferograms in the near-infrared H and K bands with the VLTI/AMBER instrument. The derived visibilities, closure phases and the SED of KK Oph were compared with two-dimensional geometric and radiative transfer models (RADMC). We obtained visibilities at four different position angles. Using two-dimensional geometric models, we derive an axis ratio ˜3.0 corresponding to an inclination of ˜70 degree. A fitted inclined ring model leads to a ring radius of 2.8 ± 0.2 mas, corresponding to 0.44 ± 0.03 AU at a distance of 160 pc, which is larger than the dust sublimation radius of ˜0.1 AU predicted for a dust sublimation temperature of 1500 K. Our derived two-dimensional RADMC model consists of a circumstellar disk with an inclination angle of ˜70 degree and an additional dust envelope. The finding of an ˜70 degree inclined disk around KK Oph is consistent with the prediction that UX <span class="hlt">Ori</span> objects are seen under large inclination angles, and orbiting clouds in the line of sight cause the observed variability. Furthermore, our results suggest that the orbit of the companion KK Oph B and the disk plane are coplanar.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4392467','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4392467"><span id="translatedtitle">The Design and Relevance of a Computerized Gamified Depression Therapy Program for Indigenous Mā<span class="hlt">ori</span> Adolescents</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Fleming, Theresa; Lucassen, Mathijs; Stasiak, Karolina</p> <p>2015-01-01</p> <p>Background Depression is a major health issue among Mā<span class="hlt">ori</span> indigenous adolescents, yet there has been little investigation into the relevance or effectiveness of psychological treatments for them. Further, consumer views are critical for engagement and adherence to therapy. However, there is little research regarding indigenous communities’ opinions about psychological interventions for depression. Objective The objective of this study was to conduct semistructured interviews with Mā<span class="hlt">ori</span> (indigenous New Zealand) young people (taitamariki) and their families to find out their opinions of a prototype computerized cognitive behavioral therapy (cCBT) program called Smart, Positive, Active, Realistic, X-factor thoughts (SPARX), a free online computer game intended to help young persons with mild to moderate depression, feeling down, stress or anxiety. The program will teach them how to resolve their issues on their own using Cognitive Behavioural Therapy as psychotherapeutic approach. Methods There were seven focus groups on the subject of the design and cultural relevance of SPARX that were held, with a total of 26 participants (19 taitamarki, 7 parents/caregivers, all Mā<span class="hlt">ori</span>). There were five of the groups that were with whānau (family groups) (n=14), one group was with Mā<span class="hlt">ori</span> teenage mothers (n=4), and one group was with taitamariki (n=8). The general inductive approach was used to analyze focus group data. Results SPARX computerized therapy has good face validity and is seen as potentially effective and appealing for Mā<span class="hlt">ori</span> people. Cultural relevance was viewed as being important for the engagement of Mā<span class="hlt">ori</span> young people with SPARX. Whānau are important for young peoples’ well-being. Participants generated ideas for improving SPARX for Mā<span class="hlt">ori</span> and for the inclusion of whānau in its delivery. Conclusions SPARX computerized therapy had good face validity for indigenous young people and families. In general, Mā<span class="hlt">ori</span> participants were positive about the SPARX prototype and considered it both appealing and applicable to them. The results of this study were used to refine SPARX prior to it being delivered to taitamariki and non-Mā<span class="hlt">ori</span> young people. Trial Registration The New Zealand Northern Y Regional Ethics Committee; http://ethics.health.govt.nz/home; NTY/09/003; (Archived by WebCite at http://www.webcitation/6VYgHXKaR). PMID:25736225</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/21344488','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/21344488"><span id="translatedtitle">Direct Imaging of the Pre-outburst FU <span class="hlt">Ori</span> Candidate V1331 Cyg</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Kitamura, Misae; Yamada, Tom; Tamura, Motohide; Kudo, Tomoyuki</p> <p>2009-08-05</p> <p>We carried out a direct imaging campaign of the pre-outburst FU <span class="hlt">Ori</span> candidate V1331 Cyg in the H band with CIAO on the Subaru Telescope to investigate the inner structures of VI331 Cyg and to directly detect the disk. Spatial structures revealed by direct imaging may describe the physical conditions of the disk and can restrict the theories of planetary formation. In our preliminary results, we clearly detected a bright arc interior to the known inner ring, which is likely to be the scattered light from the disk. Here, we will show the results and discuss nature of the structure including the comparison with the HST images.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2009AIPC.1158..135K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2009AIPC.1158..135K"><span id="translatedtitle">Direct Imaging of the Pre-outburst FU <span class="hlt">Ori</span> Candidate V1331 Cyg</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kitamura, Misae; Yamada, Tom; Tamura, Motohide; Kudo, Tomoyuki</p> <p>2009-08-01</p> <p>We carried out a direct imaging campaign of the pre-outburst FU <span class="hlt">Ori</span> candidate V1331 Cyg in the H band with CIAO on the Subaru Telescope to investigate the inner structures of VI331 Cyg and to directly detect the disk. Spatial structures revealed by direct imaging may describe the physical conditions of the disk and can restrict the theories of planetary formation. In our preliminary results, we clearly detected a bright arc interior to the known inner ring, which is likely to be the scattered light from the disk. Here, we will show the results and discuss nature of the structure including the comparison with the HST images.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2010HiA....15..751C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2010HiA....15..751C"><span id="translatedtitle">Warm and hot circumstellar gas in V1647 <span class="hlt">Ori</span> during the 2008-2009 outburst</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Carmona, A.; Audard, M.; van den Ancker, M.; van der Plas, G.; Goto, M.; Fedele, D.</p> <p>2010-11-01</p> <p>The pre-main sequence star V1647 <span class="hlt">Ori</span> started a new outburst in August 2008. From October 2008 to February 2009 we monitored V1647 <span class="hlt">Ori</span>, obtaining quasi-simultaneous VLT-CRIRES near-IR spectroscopy, VLT-VISIR mid-IR spectroscopy and VLT-FORS2 optical spectroscopy. We studied the evolution of H2 and CO emission from hot and warm gas and H? and forbidden line-emission during the initial outburst phase of V1647 <span class="hlt">Ori</span>. H? is observed in emission displaying P-Cygni profiles with blue-shifted absorption up to -700 km/s, suggesting the presence of a high velocity wind (Fig. 1a). [OI] emission at 6300 is observed displaying a blue-shifted emission shoulder, indicating the presence of material moving away from the star (Fig. 1b). We detect H2 1-0 S(1) and CO (P4 to P14 and P30-P38) ro-vibrational lines centered at the velocity of the star at all epochs (Fig. 1c & d). This strongly suggests that the H2 and CO emission originates from a disk and not from a warm outflow. The H2 1-0 S(0) and 2-1 S(1) ro-vibrational lines at 2.22 and 2.24 ?m and the pure-rotational H2 0-0 S(1) and 0-0 S(2) lines at 17 and 12 ?m were not detected in our spectra. Changes in the H? and [OI] profiles and the H2 and CO emission observed do not correlate. We modeled the H2 and CO line profiles assuming emission from a flat disk in keplerian rotation with line intensity decreasing with radius (I ~ I0(R/Rmin)-?). We found that the disk of V1647 <span class="hlt">Ori</span> is observed nearly face-on and that the line emission is produced within a fraction of an AU of the star (Fig. 1d).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21845732','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21845732"><span id="translatedtitle">Cranial muscles of the anurans Leiopelma hochstetteri and Ascaphus truei and the homologies of the mandibular adductors in Lissamphibia and other gnathostomes.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Johnston, Peter</p> <p>2011-12-01</p> <p>The frogs Ascaphus truei and Leiopelma hochstetteri are members of the most basal lineages of extant anurans. Their cranial muscles have not been previously described in full and are investigated here by dissection. Comparison of these taxa is used to review a controversy regarding the homologies of the jaw adductor muscles in Lissamphibia, to place these homologies in a wider gnathostome context, and to define features that may be useful for cladistic analysis of Anura. A new muscle is defined in Ascaphus and is designated m. <span class="hlt">levator</span> <span class="hlt">anguli</span> <span class="hlt">oris</span>. The differences noted between Ascaphus and Leiopelma are in the penetration of the jaw adductor muscles by the mandibular nerve (V3). In the traditional view of this anatomy, the paths of the trigeminal nerve branches define homologous muscles. This scheme results in major differences among frogs, salamanders, and caecilians. The alternative view is that the topology of origins, insertions, and fiber directions are defining features, and the nerves penetrate the muscle mass in a variable way. The results given here support the latter view. A new model is proposed for Lissamphibia, whereby the adductor posterior (<span class="hlt">levator</span> articularis) is a separate entity, and the rest of the adductor mass is configured around it as a folded sheet. This hypothesis is examined in other gnathostomes, including coelacanth and lungfish, and a possible sequence for the evolution of the jaw muscles is demonstrated. In this system, the main jaw adductor in teleost fish is not considered homologous with that of tetrapods. This hypothesis is consistent with available data on the domain of expression of the homeobox gene engrailed 2, which has previously not been considered indicative of homology. Terminology is discussed, and "adductor mandibulae" is preferred to "<span class="hlt">levator</span> mandibulae" to align with usage in other gnathostomes. PMID:21845732</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3508430','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3508430"><span id="translatedtitle">Comparison of the puborectal muscle on MRI in women with POP and <span class="hlt">levator</span> ani defects with those with normal support and no defect</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>DeLancey, John O. L.; Srensen, Helle Christina; Lewicky-Gaupp, Christina</p> <p>2012-01-01</p> <p>Introduction and hypothesis The objective of this study was to compare puborectal muscle integrity and bulk in women with both major <span class="hlt">levator</span> ani (LA) defects on MRI and pelvic organ prolapse (POP) to women with normal LA muscle and normal support. Methods This is a case-control study comparing 24 cases with known major LA defects and POP to 24 controls with normal LA and normal support. Axial T-2 weighted MRI scans of the pelvis were evaluated for integrity of the puborectal muscle and degree of muscle bulk. Results There were no significant group differences in age, body mass index, vaginal deliveries, or hysterectomy status. In all 48 subjects, the puborectal muscle was visible and had no disruption noted. There was no difference in muscle bulk between groups (control/case, thin 42% vs. 25%, average 42% vs. 38%, thick-17% vs. 38%; P=0.47). Conclusions Defects and loss of muscle bulk in the puborectal muscle are not seen on MRI in women with major LA defects and POP. PMID:21822711</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25193966','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25193966"><span id="translatedtitle">Redesigning the architecture of policy-making: Engaging with M?<span class="hlt">ori</span> on nanotechnology in New Zealand.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Munshi, Debashish; Kurian, Priya A; Morrison, Talei; Morrison, Sandra L</p> <p>2014-09-01</p> <p>Although there is an extensive literature on public engagement on the use of new and emerging technologies such as nanotechnology, there is little evidence of the participation of marginalised indigenous communities in processes of such engagement. How do particular cultural values and worldviews shape the perceptions of new technologies among such indigenous peoples? This article addresses this question through an analysis of the deliberations of an indigenous M?<span class="hlt">ori</span> citizens' panel on nanotechnology in Aotearoa New Zealand. An active process of public engagement with the nation's M?<span class="hlt">ori</span> stakeholders, and their conversations with nanotechnology experts, sustainability activists and M?<span class="hlt">ori</span> researchers, helps map an alternative, culture-based architecture of public engagement on policies around new technologies. The analysis is grounded in a concept of active citizenship that we term 'sustainable citizenship'. PMID:25193966</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4262642','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4262642"><span id="translatedtitle">Lethality of Sortase Depletion in Actinomyces <span class="hlt">oris</span> Caused by Excessive Membrane Accumulation of a Surface Glycoprotein</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Wu, Chenggang; Huang, I-Hsiu; Chang, Chungyu; Reardon-Robinson, Melissa Elizabeth; Das, Asis; Ton-That, Hung</p> <p>2014-01-01</p> <p>Sortase, a cysteine-transpeptidase conserved in Gram-positive bacteria, anchors on the cell wall many surface proteins that facilitate bacterial pathogenesis and fitness. Genetic disruption of the housekeeping sortase in several Gram-positive pathogens reported thus far attenuates virulence, but not bacterial growth. Paradoxically, we discovered that depletion of the housekeeping sortase SrtA was lethal for Actinomyces <span class="hlt">oris</span>; yet, all of its predicted cell wall-anchored protein substrates (AcaA-N) were individually dispensable for cell viability. Using Tn5-transposon mutagenesis to identify factors that upend lethality of srtA deletion, we uncovered a set of genetic suppressors harboring transposon insertions within genes of a locus encoding AcaC and a LytR-CpsA-Psr (LCP)-like protein. AcaC was shown to be highly glycosylated and dependent on LCP for its glycosylation. Upon SrtA depletion, the glycosylated form of AcaC, hereby renamed GspA, was accumulated in the membrane. Overexpression of GspA in a mutant lacking gspA and srtA was lethal; conversely, cells overexpressing a GspA mutant missing a membrane-localization domain were viable. The results reveal a unique glycosylation pathway in A. <span class="hlt">oris</span> that is coupled to cell wall anchoring catalyzed by sortase SrtA. Significantly, this novel phenomenon of glyco-stress provides convenient cell-based assays for developing a new class of inhibitors against Gram-positive pathogens. PMID:25230351</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3557718','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3557718"><span id="translatedtitle">Pathogenicity of exopolysaccharide-producing Actinomyces <span class="hlt">oris</span> isolated from an apical abscess lesion</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Yamane, K; Nambu, T; Yamanaka, T; Ishihara, K; Tatami, T; Mashimo, C; Walker, C B; Leung, K-P; Fukushima, H</p> <p>2013-01-01</p> <p>Aim To demonstrate a capacity for producing exopolysaccharides (EPSs) and an ability to form biofilm on abiotic materials of Actinomyces <span class="hlt">oris</span> strain K20. Methodology The productivity of EPSs and the ability to form biofilm of strain K20 were evaluated by measuring viscosity of spent culture media and by scanning electron microscopy (SEM) and the biofilm assay on microtitre plates, respectively. High-performance liquid chromatography was used to determine the chemical composition of the viscous materials. To examine the role of the viscous materials attributable to the pathogenicity in this organism, the ability of strain K20 to induce abscess formation was compared in mice to that of ATCC 27044. Results The viscosity of the spent culture media of K20 was significantly higher than that of ATCC 27044. Strain K20 showed dense meshwork structures around the cells and formed biofilms on microtitre plates, whereas ATCC 27044 did not. Chemical analysis of the viscous materials revealed that they were mainly composed of neutral sugars with mannose constituting 77.5% of the polysaccharides. Strain K20 induced persistent abscesses in mice lasting at least 5 days at a concentration of 108 cells mL−1, whereas abscesses induced by ATCC 27044 healed and disappeared or decreased in size at day 5. Conclusions Strain K20 produced EPSs, mainly consisting of mannose, and formed biofilms. This phenotype might play an important role for A. <span class="hlt">oris</span> to express virulence through the progression of apical periodontitis. PMID:22900599</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25230351','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25230351"><span id="translatedtitle">Lethality of sortase depletion in Actinomyces <span class="hlt">oris</span> caused by excessive membrane accumulation of a surface glycoprotein.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wu, Chenggang; Huang, I-Hsiu; Chang, Chungyu; Reardon-Robinson, Melissa Elizabeth; Das, Asis; Ton-That, Hung</p> <p>2014-12-01</p> <p>Sortase, a cysteine-transpeptidase conserved in Gram-positive bacteria, anchors on the cell wall many surface proteins that facilitate bacterial pathogenesis and fitness. Genetic disruption of the housekeeping sortase in several Gram-positive pathogens reported thus far attenuates virulence, but not bacterial growth. Paradoxically, we discovered that depletion of the housekeeping sortase SrtA was lethal for Actinomyces <span class="hlt">oris</span>; yet, all of its predicted cell wall-anchored protein substrates (AcaA-N) were individually dispensable for cell viability. Using Tn5-transposon mutagenesis to identify factors that upend lethality of srtA deletion, we uncovered a set of genetic suppressors harbouring transposon insertions within genes of a locus encoding AcaC and a LytR-CpsA-Psr (LCP)-like protein. AcaC was shown to be highly glycosylated and dependent on LCP for its glycosylation. Upon SrtA depletion, the glycosylated form of AcaC, hereby renamed GspA, was accumulated in the membrane. Overexpression of GspA in a mutant lacking gspA and srtA was lethal; conversely, cells overexpressing a GspA mutant missing a membrane-localization domain were viable. The results reveal a unique glycosylation pathway in A. <span class="hlt">oris</span> that is coupled to cell wall anchoring catalysed by sortase SrtA. Significantly, this novel phenomenon of glyco-stress provides convenient cell-based assays for developing a new class of inhibitors against Gram-positive pathogens. PMID:25230351</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014APS..MARL16004E','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014APS..MARL16004E"><span id="translatedtitle">Metallurgy of Miura-<span class="hlt">ori</span>: lattice theory for inhomogeneous deformations of origami tessellations</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Evans, Arthur; Silverberg, Jesse; McLeod, Lauren; Cohen, Itai; Santangelo, Christian</p> <p>2014-03-01</p> <p>In nature, as well as in art, one often encounters thin materials that have been deformed by their environment or their creator into complex folded states; examples include the folds of the endoplasmic reticulum, the villi in the intestinal tract, and tessellated patterns in the ancient Japanese art of origami. One (engineering) advantage of creating a folded structure is that the geometric constraints associated with creasing imbues the construction with exotic mechanical properties, such as generating a material with a negative Poisson's ratio. Materials exhibiting novel behavior of this type, arising from the special properties of the unit cell, are generally classified as metamaterials. In this talk I consider a mechanical metamaterial known as Miura-<span class="hlt">ori</span>, an origami tessellation pattern that displays soft modes and crystallographic defects not accounted for by a purely geometric theory of an infinitely thin material. I will discuss a method for deriving how inhomogeneous deformations arise from bending within Miura-<span class="hlt">ori</span>, and show that this leads to a natural coherence length over which the inhomogeneity decays. Additionally, I will show how the modular nature of origami unit cells lends additional richness to the mechanical properties associated with deformation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3608319','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3608319"><span id="translatedtitle">An indigenous approach to explore health-related experiences among M?<span class="hlt">ori</span> parents: the Pukapuka Hauora asthma study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2013-01-01</p> <p>Background The prevalence of asthma for Indigenous New Zealand M?<span class="hlt">ori</span> is amongst the highest in the world. Recent evidence shows ethnic differences in asthma symptom prevalence in New Zealand have widened, with asthma symptoms and hospitalisation rates consistently higher for M?<span class="hlt">ori</span> across all age-groups, especially children and adolescents. This paper: outlines our qualitative, longitudinal research exploring the practical issues M?<span class="hlt">ori</span> children and their families face trying to achieve optimum asthma outcomes; details the research methods used within this study; and discusses the process evaluation findings of the features that made this approach successful in engaging and retaining participants in the study. Methods Thirty-two M?<span class="hlt">ori</span> families were recruited using a Kaupapa M?<span class="hlt">ori</span> (M?<span class="hlt">ori</span> way) Research approach. Each participated in a series of four in-depth interviews that were carried out at seasonal intervals over the course of one year. Families also took part in an interviewer-administered questionnaire and participated in a Photovoice exercise. All interviews were digitally recorded, transcribed verbatim and independently coded by two researchers. The research team then conducted the analysis and theme development. The questionnaires were analysed separately, with explanations for findings explored within the qualitative data. Results The methodology produced a 100 percent retention rate of the participating families over the course of the follow-up. This was attributed to the research collaboration, the respectful research relationships established with families, and the families judgement that the methods used enabled them to tell their stories. The acceptability of the methodology will add to the validity and trustworthiness of the findings. Conclusion Given the extent and persistence of ethnic disparities in childhood asthma management, it is imperative that an indigenous approach be taken to understanding the core issues facing M?<span class="hlt">ori</span> families. By conducting community-partnership research underpinned by an indigenous methodology, and employing a range of appropriate methods, we have successfully recruited and retained a cohort of M?<span class="hlt">ori</span> families with experiences of childhood asthma. We aim to make their voices heard in order to develop a series of culturally relevant interventions aimed at remediating these disparities. PMID:23497423</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25645659','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25645659"><span id="translatedtitle">The significance of socially-assigned ethnicity for self-identified Mā<span class="hlt">ori</span> accessing and engaging with primary healthcare in New Zealand.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Reid, Jennifer; Cormack, Donna; Crowe, Marie</p> <p>2016-03-01</p> <p>Despite increased focus in New Zealand on reducing health inequities between Mā<span class="hlt">ori</span> and New Zealand European ethnic groups, research on barriers and facilitators to primary healthcare access for Mā<span class="hlt">ori</span> remains limited. In particular, there has been little interrogation of the significance of social-assignment of ethnicity for Mā<span class="hlt">ori</span> in relation to engagement with predominantly non-Mā<span class="hlt">ori</span> primary healthcare services and providers. A qualitative study was undertaken with a subsample (n = 40) of the broader Hauora Manawa Study to examine experiences of accessing and engaging with primary healthcare among adult urban Mā<span class="hlt">ori</span>. Thematic analysis of in-depth interviews identified that participants perceived social-assignment as New Zealand European as an efficacious form of capital when interacting with predominantly non-Mā<span class="hlt">ori</span> health professionals. Skin colour that was 'white' or was perceived to identify Mā<span class="hlt">ori</span> as belonging to the 'dominant' New Zealand European ethnic group was reported as broadly advantageous and protective. In contrast, social-assignment as Mā<span class="hlt">ori</span> was seen to be associated with risk of exposure to differential and discriminatory healthcare. Reducing the negative impacts of racialisation in a (neo)colonial society where 'White' cultural capital dominates requires increased recognition of the health-protective advantages of 'White' privilege and concomitant risks associated with socially-assigned categorisation of ethnicity as non-'White'. PMID:25645659</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2667307','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2667307"><span id="translatedtitle">Evidence for recombination between a sialidase (nanH) of Actinomyces naeslundii and Actinomyces <span class="hlt">oris</span>, previously named Actinomyces naeslundii genospecies 1 and 2</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Do, Thuy; Henssge, Uta; Gilbert, Steven C; Clark, Douglas; Beighton, David</p> <p>2008-01-01</p> <p>Actinomyces spp., predominant members of human oral biofilms, may use extracellular sialidase to promote adhesion, deglycosylate immunoglobulins and liberation of nutrients. Partial nanH gene sequences (1077 bp) from Actinomyces <span class="hlt">oris</span> (n =74), Actinomyces naeslundii (n =30), Actinomyces viscosus (n =1) and Actinomyces johnsonii (n =2) which included the active-site region and the bacterial neuraminidase repeats (BNRs) were compared. The sequences were aligned and each species formed a distinct cluster with five isolates having intermediate positions. These five isolates (two A. <span class="hlt">oris</span> and three A. naeslundii) exhibited interspecies recombination. The nonsynonymous/synonymous ratio was <1 for both A. <span class="hlt">oris</span> and A. naeslundii indicating that nanH in both species is under stabilizing selective pressure; nonsynonymous mutations are not selected. However, for A. <span class="hlt">oris</span> significant negative values in tests for neutral selection suggested the rate of mutation in A. <span class="hlt">oris</span> was greater than in A. naeslundii but with selection against nonsynonymous mutations. This was supported by the observation that the frequency of polymorphic sites in A. <span class="hlt">oris</span>, which were monomorphic in A. naeslundii was significantly greater than the frequency of polymorphic sites in A. naeslundii which were monomorphic in A. <span class="hlt">oris</span> (?2=7.011; P =0.00081). The higher proportions of A. <span class="hlt">oris</span> in the oral biofilm might be explained by the higher mutation rate facilitating an increased ability to respond successfully to environmental stress. PMID:18823396</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24708455','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24708455"><span id="translatedtitle">The protective influence of family connectedness, ethnic identity, and ethnic engagement for New Zealand Ma̅<span class="hlt">ori</span> adolescents.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stuart, Jaimee; Jose, Paul E</p> <p>2014-06-01</p> <p>The present study examined the associations among family connectedness, ethnic identity, and ethnic engagement on changes in well-being over time for the understudied population of Ma̅<span class="hlt">ori</span> (indigenous New Zealand) youth. Data were collected as part of a longitudinal study of youth connectedness in New Zealand using self-report measures at 3 measurement occasions separated by 1 year each. Participants in the current study were 431 self-identified Ma̅<span class="hlt">ori</span> (ages 10-15 years at Time 1). As expected, the variables of family connectedness, ethnic identity, and well-being were all positively related to each other. Results of a latent growth curve model showed that, following normative trends for adolescents of this age, well-being diminished over time for Ma̅<span class="hlt">ori</span> youth; however, high levels of family connectedness were found to mitigate this general decline in well-being over time. Furthermore, in a longitudinal path analysis, ethnic engagement was found to exert a positive indirect effect on residualized Time 3 well-being through Time 2 ethnic identity. These findings indicate that the quality of family relationships and affiliation with one's ethnic group are important predictors of positive adjustment for Ma̅<span class="hlt">ori</span> youth over time. These results are discussed in the context of positive youth development for ethnic minority and indigenous youth. PMID:24708455</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=ethnic+AND+identity&pg=3&id=EJ1051416','ERIC'); return false;" href="http://eric.ed.gov/?q=ethnic+AND+identity&pg=3&id=EJ1051416"><span id="translatedtitle">The Protective Influence of Family Connectedness, Ethnic Identity, and Ethnic Engagement for New Zealand Ma<span class="hlt">ori</span> Adolescents</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Stuart, Jaimee; Jose, Paul E.</p> <p>2014-01-01</p> <p>The present study examined the associations among family connectedness, ethnic identity, and ethnic engagement on changes in well-being over time for the understudied population of Ma<span class="hlt">ori</span> (indigenous New Zealand) youth. Data were collected as part of a longitudinal study of youth connectedness in New Zealand using self-report measures at 3</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005hris.conf..419L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005hris.conf..419L"><span id="translatedtitle">Spectroscopy of the M Supergiant ? <span class="hlt">Ori</span> in the 1 2.5 ?m Region</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Lundqvist, Martin; Wahlgren, Glenn</p> <p></p> <p>The study of elemental abundances in cool stars via atomic lines in the optical region is made di.cult by stellar molecular absorption. At infrared wavelengths this problem is diminished, but ground-based observations suffer from absorption by the earths atmosphere. Fortunately, there are spectral windows through which we can observe. We have explored several such windows in the spectral region from 1 2.5 ?m, coinciding with the wavelength domain of the new VLT instrument CRIRES, for atomic lines suitable for the study of cool luminous stars, in particular ? <span class="hlt">Ori</span> (M2Iab). We present preliminary results from this search along with our first results on abundances of iron and the weak s-process elements Sr, Y, Zr.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014AAS...22315107N','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014AAS...22315107N"><span id="translatedtitle">Time-Resolved X-ray Spectroscopy of the Massive Binary delta <span class="hlt">Ori</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Nichols, Joy S.; Naze, Y.; Corcoran, M. F.; Pollock, A.; Moffat, A. F.; Ignace, R.; Waldron, W. L.; Evans, N. R.</p> <p>2014-01-01</p> <p>We have obtained 500 ks of Chandra HETG observations of the massive binary delta <span class="hlt">Ori</span> (O9.5II+unseen companion), one of the fundamental calibrators of the mass-luminosity-radius relation in the upper HR diagram. The program is intended to map the emission line parameters as the secondary moves through the wind of the primary star. Custom extraction techniques have been developed to create 12 time-resolved 40 ks spectra from these observations, each of which is properly calibrated for time and temperature effects. Emission line fluxes for these time slice spectra are presented, as well as phase analysis of the variability of the fluxes. We discuss the interpretation of the resulting data, such as colliding winds and occultation of various temperature regimes of the primary wind by the secondary.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li class="active"><span>6</span></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_6 --> <div id="page_7" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li class="active"><span>7</span></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="121"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1996A%26A...313..857G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1996A%26A...313..857G"><span id="translatedtitle">Evaporation of star-grazing bodies in the vicinity of UX <span class="hlt">Ori</span>-type stars.</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Grinin, V.; Natta, A.; Tambovtseva, L.</p> <p>1996-09-01</p> <p>This paper studies the behaviour of star-grazing planetesimal bodies in the neighbourhood of UX <span class="hlt">Ori</span>-type stars. When approaching a star, large size bodies (diameteres of ten meters or more) disintegrate into a number of small fragments under the effect of thermal stresses. In turn, the fragments sublimate within a sphere of about ten stellar radii and form a circumstellar gas envelope. An important feature of this envelope is a strong excess of heavy elements. Our calculations show that the radiative force on the metal-enriched gas is much larger than in the case of standard chemical composition and exceeds by few times the gravity of the star. As a result, the evaporated matter is accelerated outward and is expelled from the system by radiative pressure. Thus, the evaporation of planetesimals in the vicinity of young stars leads to complex gas motions which include infall, quasi-keplerian rotation and the radial outflow typical of radiatively driven stellar winds.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/18789041','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/18789041"><span id="translatedtitle">Crisis engagement in mental health: a New Zealand Mā<span class="hlt">ori</span> contribution.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Drury, Nick; Munro, Te Ata</p> <p>2008-10-01</p> <p>The active engagement of clients in mental health services offers far greater chances of successful outcomes. When clients do not actively engage in treatment, their risk of becoming part of the population of 'high users' is greater. The 'high users' consume a disproportionate share of health resources, which may prevent other potential clients from accessing services. Engagement can be particularly challenging in crisis situations, which is how many clients attracting psychotic diagnoses first enter the service. New Zealand Mā<span class="hlt">ori</span> bring a transcendent quality to the idea of 'respect for Other', which would make it sacrilegious to overpower Other in most situations. This paper reviews a growing body of literature indicating how we might integrate an enhanced respect or reverence of Other into clinical practice. This includes the idea of engaging more frequently with the social network when building rapport with an individual is particularly challenging. There is some evidence that services adopting this kind of approach are more economical. PMID:18789041</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1166500','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1166500"><span id="translatedtitle">Ultrastructure of the angularis <span class="hlt">oris</span> salivary gland in the house sparrow.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Nagato, T; Tandler, B</p> <p>1986-01-01</p> <p>The angularis <span class="hlt">oris</span> gland, an avian salivary gland that lies beneath the zygomatic arch, was studied in the house sparrow by means of light and electron microscopy. The gland consists of lobules composed of epithelial tubules and folds on a delicate connective tissue framework. The lobules are drained by large channels to form an intraglandular duct, which becomes the main extraglandular duct. The tubules, folds, and all ducts are covered by pseudostratified epithelium that shows progressive changes from the blind ends of tubules to the duct system. At the closed end of the tubules, the tall cells contain an aggregation of closely packed mucous droplets; their mitochondria are long and slender. As the epithelium nears the duct system, the mucus content of the tall cells is reduced and the mitochondria, which are increased in number, are ovoid. The lateral borders of the cells are complexly interlocked. In the ducts, mitochondria-rich cells with extensive lateral interfoliation comprise the major cell type; some of these cells contain a few mucous droplets at their apices. The basal cells of the pseudostratified epithelium have the same basic structure regardless of their location. These pyramidal cells have abundant cytofilaments and are joined to the basal lamina by many hemidesmosomes. Despite the absence of clear-cut morphological zonation, the angularis <span class="hlt">oris</span> may function in a manner that is analogous to mammalian salivary glands: secretory cells produce the organic component of the saliva, mucus, while the mitochondria-rich cells with their extensive lateral membranes probably resorb electrolytes to render the final saliva hypotonic. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7 Fig. 8 Fig. 9 Fig. 10 Fig. 11 Fig. 12 PMID:3429300</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23702212','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23702212"><span id="translatedtitle">Ethnic density and area deprivation: neighbourhood effects on Mā<span class="hlt">ori</span> health and racial discrimination in Aotearoa/New Zealand.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bécares, Laia; Cormack, Donna; Harris, Ricci</p> <p>2013-07-01</p> <p>Some studies suggest that ethnic minority people are healthier when they live in areas with a higher concentration of people from their own ethnic group, a so-called ethnic density effect. To date, no studies have examined the ethnic density effect among indigenous peoples, for whom connections to land, patterns of settlement, and drivers of residential location may differ from ethnic minority populations. The present study analysed the Mā<span class="hlt">ori</span> sample from the 2006/07 New Zealand Health Survey to examine the association between increased Mā<span class="hlt">ori</span> ethnic density, area deprivation, health, and experiences of racial discrimination. Results of multilevel regressions showed that an increase in Mā<span class="hlt">ori</span> ethnic density was associated with decreased odds of reporting poor self-rated health, doctor-diagnosed common mental disorders, and experienced racial discrimination. These associations were strengthened after adjusting for area deprivation, which was consistently associated with increased odds of reporting poor health and reports of racial discrimination. Our findings show that whereas ethnic density is protective of the health and exposure to racial discrimination of Mā<span class="hlt">ori</span>, this effect is concealed by the detrimental effect of area deprivation, signalling that the benefits of ethnic density must be interpreted within the current socio-political context. This includes the institutional structures and racist practices that have created existing health and socioeconomic inequities in the first place, and maintain the unequal distribution of concentrated poverty in areas of high Mā<span class="hlt">ori</span> density. Addressing poverty and the inequitable distribution of socioeconomic resources by ethnicity and place in New Zealand is vital to improving health and reducing inequalities. Given the racialised nature of access to goods, services, and opportunities within New Zealand society, this also requires a strong commitment to eliminating racism. Such commitment and action will allow the benefits potentially flowing from strong communities to be fully realised. PMID:23702212</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2874997','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2874997"><span id="translatedtitle">DnaB proteolysis in vivo regulates oligomerization and its localization at <span class="hlt">ori</span>C in Bacillus subtilis</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Grainger, William H.; Machn, Cristina; Scott, David J.; Soultanas, Panos</p> <p>2010-01-01</p> <p>Initiation of bacterial DNA replication at <span class="hlt">ori</span>C is mediated by primosomal proteins that act cooperatively to melt an AT-rich region where the replicative helicase is loaded prior to the assembly of the replication fork. In Bacillus subtilis, the dnaD, dnaB and dnaI genes are essential for initiation of DNA replication. We established that their mRNAs are maintained in fast growing asynchronous cultures. DnaB is truncated at its C-terminus in a growth phase-dependent manner. Proteolysis is confined to cytosolic, not to membrane-associated DnaB, and affects oligomerization. Truncated DnaB is depleted at the <span class="hlt">ori</span>C relative to the native protein. We propose that DNA-induced oligomerization is essential for its action at <span class="hlt">ori</span>C and proteolysis regulates its localization at <span class="hlt">ori</span>C. We show that DnaB has two separate ssDNA-binding sites one located within residues 1300 and another between residues 365428, and a dsDNA-binding site within residues 365428. Tetramerization of DnaB is mediated within residues 1300, and DNA-dependent oligomerization within residues 365428. Finally, we show that association of DnaB with the <span class="hlt">ori</span>C is asymmetric and extensive. It encompasses an area from the middle of dnaA to the end of yaaA that includes the AT-rich region melted during the initiation stage of DNA replication. PMID:20071750</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4198482','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4198482"><span id="translatedtitle">KIR Diversity in M?<span class="hlt">ori</span> and Polynesians: Populations in which HLA-B is not a Significant KIR Ligand</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Nemat-Gorgani, Neda; Edinur, Hisham A.; Hollenbach, Jill A.; Traherne, James A.; Dunn, Paul P. J.; Chambers, Geoffrey K.; Parham, Peter; Norman, Paul J.</p> <p>2014-01-01</p> <p>HLA class I molecules and killer cell immunoglobulin-like receptors (KIR) form a diverse system of ligands and receptors that individualize human immune systems in ways that improve the survival of individuals and populations. Human settlement of Oceania by island-hopping East and Southeast Asian migrants started ~3,500 years ago. Subsequently, New Zealand was reached ~750 years ago by ancestral M?<span class="hlt">ori</span>. To examine how this history impacted KIR and HLA diversity, and their functional interaction, we defined at high resolution the allelic and haplotype diversity of the 13 expressed KIR genes in 49 M?<span class="hlt">ori</span> and 34 Polynesians. Eighty KIR variants, including four new alleles, were defined; as were 35 centromeric and 22 telomeric KIR region haplotypes, which combine to give >50 full-length KIR haplotypes. Two new and divergent variant KIR form part of a telomeric KIR haplotype, which appears derived from Papua New Guinea and was probably obtained by the Asian migrants en route to Polynesia. M?<span class="hlt">ori</span> and Polynesian KIR are very similar, but differ significantly from African, European, Japanese and Amerindian KIR. M?<span class="hlt">ori</span> and Polynesians have high KIR haplotype diversity with corresponding allotype diversity being maintained throughout the KIR locus. Within the population each individual has a unique combination of HLA class I and KIR. Characterizing M?<span class="hlt">ori</span> and Polynesians is a paucity of HLA-B allotypes recognized by KIR. Compensating for this deficiency are high frequencies (>50%) of HLA-A allotypes recognized by KIR. These HLA-A allotypes are ones that modern humans likely acquired from archaic humans at a much earlier time. PMID:25139336</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=205490','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=205490"><span id="translatedtitle">Conjugation-independent, site-specific recombination at the <span class="hlt">ori</span>T of the IncW plasmid R388 mediated by TrwC.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Llosa, M; Bolland, S; Grandoso, G; de la Cruz, F</p> <p>1994-01-01</p> <p>Plasmids containing a direct repeat of plasmid R388 <span class="hlt">ori</span>T are capable of site-specific recombination, which results in deletion of the intervening DNA. This reaction occurs in the presence, but not in the absence, of the region of R388 implicated in DNA processing during conjugation. This region contains three genes, trwA, trwB, and trwC. By using mutants of each of the three genes, it was demonstrated that only trwC is required for the <span class="hlt">ori</span>T-specific recombination. Further analysis showed that the N-terminal 272 amino acids of the protein are sufficient to catalyze recombination. TrwC is also capable of promoting intermolecular recombination between two plasmids containing <span class="hlt">ori</span>T, suggesting that double-strand breaks in both plasmid DNAs are involved in the process. Additionally, intramolecular recombination between R388 <span class="hlt">ori</span>T and R46 <span class="hlt">ori</span>T did not occur in the presence of both nickases. This suggests that the half-reactions at each <span class="hlt">ori</span>T are not productive if they occur separately; therefore, an interaction between the recombination complexes formed at each recombining site is required. This is the first report in which a nicking-closing enzyme involved in conjugal DNA transfer promotes <span class="hlt">ori</span>T-specific recombination of double-stranded DNA in the absence of conjugation. Images PMID:8195075</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/22126796','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/22126796"><span id="translatedtitle">DRAMATIC EVOLUTION OF THE DISK-SHAPED SECONDARY IN THE ORION TRAPEZIUM STAR {theta}{sup 1} <span class="hlt">Ori</span> B{sub 1} (BM <span class="hlt">Ori</span>): MOST SATELLITE OBSERVATIONS</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Windemuth, Diana; Herbst, William; Tingle, Evan; Fuechsl, Rachel; Kilgard, Roy; Pinette, Melanie; Templeton, Matthew; Henden, Arne</p> <p>2013-05-01</p> <p>The eclipsing binary {theta}{sup 1} Orionis B{sub 1}, variable star designation BM <span class="hlt">Ori</span>, is the faintest of the four well-known Trapezium stars at the heart of the Orion Nebula. The primary is a B3 star ({approx}6 M{sub Sun }) but the nature of the secondary ({approx}2 M{sub Sun }) has long been mysterious, since the duration and shape of primary eclipse are inappropriate for any sort of ordinary star. Here we report nearly continuous photometric observations obtained with the MOST satellite over {approx}4 cycles of the 6.47 d binary period. The light curve is of unprecedented quality, revealing a deep, symmetric primary eclipse as well as a clear reflection effect and secondary eclipse. In addition, there are other small disturbances, some of which repeat at the same phase over the four cycles monitored. The shape of the primary light curve has clearly evolved significantly over the past 40 years. While its overall duration and depth have remained roughly constant, the slopes of the descent and ascent phases are significantly shallower now than in the past and its distinctive flat-bottomed ''pseudo-totality'' is much less obvious or even absent in the most recent data. We further demonstrate that the primary eclipse was detected at X-ray wavelengths during the Chandra Orion Ultradeep Project (COUP) study. The light curve continues to be well modeled by a self-luminous and reflective disk-shaped object seen nearly edge-on orbiting the B3 primary. The dramatic change in shape over four decades is modeled as an opacity variation in a tenuous outer envelope or disk of the secondary object. We presume that the secondary is an extremely young protostar at an earlier evolutionary phase than can be commonly observed elsewhere in the Galaxy and that the opacity variations observed are related to its digestion of some accreted matter over the last 50-100 years. Indeed, this object deserves continued observational and theoretical attention as the youngest known eclipsing binary system.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012MNRAS.426.2738N','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012MNRAS.426.2738N"><span id="translatedtitle">An investigation of the magnetic properties of the classical Be star ? <span class="hlt">Ori</span> by the MiMeS Collaboration</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Neiner, C.; Grunhut, J. H.; Petit, V.; ud-Doula, A.; Wade, G. A.; Landstreet, J.; de Batz, B.; Cochard, F.; Gutirrez-Soto, J.; Huat, A.-L.</p> <p>2012-11-01</p> <p>One hundred and twenty-five new high-precision spectropolarimetric observations have been obtained with ESPaDOnS (Eschelle Spectro-Polarimetric Device for the Observation of Stars) at the Canada-France-Hawaii Telescope and Narval at Tlescope Bernard Lyot to investigate the magnetic properties of the classical Be star ? <span class="hlt">Ori</span>. No Stokes V signatures are detected in our polarimetric data. Measurements of the longitudinal magnetic field, with a median error bar of 30 G, and direct modelling of the mean least-squares deconvolved Stokes V profiles yield no evidence for a dipole magnetic field with polar surface strength greater than 80 G. We are therefore unable to confirm the presence of the magnetic field previously reported by Neiner et al. However, our spectroscopic data reveal the presence of periodic emission variability in H and He lines analogous to that reported by Neiner et al., considered as evidence of magnetically confined circumstellar plasma clouds. We revisit this hypothesis in light of the new magnetic analysis. Calculation of the magnetospheric Kepler radius RK and confinement parameter ?* indicates that a surface dipole magnetic field with a polar strength larger than 63 G is sufficient to form of a centrifugally supported magnetosphere around ? <span class="hlt">Ori</span>. Our data are not sufficiently sensitive to detect fields of this magnitude; we are therefore unable to confirm or falsify the magnetic cloud hypothesis. Based on our results, we examine three possible scenarios that could potentially explain the behaviour of ? <span class="hlt">Ori</span>: (1) that no significant magnetic field is (or was) present in ? <span class="hlt">Ori</span>, and that the observed phenomena have their origin in another mechanism or mechanisms than corotating clouds. We are, however, unable to identify one; (2) that ? <span class="hlt">Ori</span> hosts an intermittent magnetic field produced by dynamo processes; however, no such process has been found so far to work in massive stars and especially to produce a dipolar field; and (3) that ? <span class="hlt">Ori</span> hosts a stable, organized (fossil) magnetic field that is responsible for the observed phenomena, but with a strength that is below our current detection threshold. Of these three scenarios, we consider the second one (dynamo process) as highly unlikely, whereas the other two should be falsifiable with intense monitoring. Based on observations obtained at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France and the University of Hawaii and observations obtained with the Narval spectropolarimeter at the Tlescope Bernard Lyot (TBL), Observatoire du Pic du Midi, France.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012AAS...21943704T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012AAS...21943704T"><span id="translatedtitle">Evidence For Accretion-driven X-ray Production In Ex Lupi And V1647 <span class="hlt">Ori</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Teets, William K.; Weintraub, D.; Grosso, N.; Principe, D.; Kastner, J.; Hamaguchi, K.; Richmond, M.</p> <p>2012-01-01</p> <p>EX Lupi is the prototype for a class of young, pre-main sequence stars, which are observed to undergo irregular optical outbursts that result in a several magnitude rise of the optical flux. EX Lupi was observed to optically erupt in 2008 January, triggering Chandra X-ray Observatory ToO observations shortly thereafter. In the 2008 March and June observations, we find the X-ray spectrum is best modeled with a two-temperature plasma with components of ˜0.4 and 1.7 keV. In subsequent observations in 2008 October, the lower-temperature plasma component appears to fade as EX Lupi returns to more quiescent optical levels. Accretion hotspots should generate plasma with temperatures of a few million Kelvin (˜0.3 keV); thus, this fading of the lower-temperature component in the spectra of EX Lupi is consistent with a decrease in accretion-generated X-ray flux from shock-heated plasma. We also find that during optical outburst, the light curve of EX Lupi appears to exhibit periodic variability of ˜37 days with the V-band flux changing by as much as ˜44 magnitudes. Similar to EX Lupi, V1647 <span class="hlt">Ori</span> is a low-mass, deeply-embedded, pre-main sequence star that has undergone two optical/NIR outbursts in the last decade; both times, the star gradually faded over several months to years. The X-ray evolution during each of these eruptions has been monitored through multi-epoch Chandra observations. Like the X-ray flux of EX Lupi, we find that the X-ray flux of V1647 <span class="hlt">Ori</span> is well correlated with the rise and fall in the optical and infrared brightnesses for both epochs; unlike EX Lupi, however, these spectra are well modeled with a single-temperature plasma of 4-6 keV. These results suggest that the primary X-ray generation mechanism for this star during optical/NIR outbursts is accretion but that the X-ray flux is likely generated by magnetic reconnection events in the accretion stream.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016MNRAS.456.2907P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016MNRAS.456.2907P"><span id="translatedtitle">X-ray, UV and optical analysis of supergiants: ɛ <span class="hlt">Ori</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Puebla, Raul E.; Hillier, D. John; Zsargó, Janos; Cohen, David H.; Leutenegger, Maurice A.</p> <p>2016-03-01</p> <p>We present a multi-wavelength (X-ray to optical) analysis, based on non-local thermodynamic equilibrium photospheric+wind models, of the B0 Ia-supergiant: ɛ <span class="hlt">Ori</span>. The aim is to test the consistency of physical parameters, such as the mass-loss rate and CNO abundances, derived from different spectral bands. The derived mass-loss rate is {dot {M}} / {√{f_{∞}}} {˜} 1.6 × 10-6 M⊙ yr-1 where f∞ is the volume filling factor. However, the S IV λλ1062,1073 profiles are too strong in the models; to fit the observed profiles it is necessary to use f∞ <0.01. This value is a factor of 5 to 10 lower than inferred from other diagnostics, and implies {dot{M}} ≲ 1 × 10^{-7} M⊙ yr-1. The discrepancy could be related to porosity-vorosity effects or a problem with the ionization of sulphur in the wind. To fit the UV profiles of N V and O VI it was necessary to include emission from an interclump medium with a density contrast (ρcl/ρICM) of ˜100. X-ray emission in H/He like and Fe L lines was modelled using four plasma components located within the wind. We derive plasma temperatures from 1 × 106 to 7 × 106 K, with lower temperatures starting in the outer regions (R0 ˜ 3-6 R*), and a hot component starting closer to the star (R0 ≲ 2.9 R*). From X-ray line profiles we infer {dot{M}} < 4.9 × 10-7 M⊙ yr-1. The X-ray spectrum (≥0.1 kev) yields an X-ray luminosity LX ˜ 2.0 × 10-7Lbol, consistent with the superion line profiles. X-ray abundances are in agreement with those derived from the UV and optical analysis: ɛ <span class="hlt">Ori</span> is slightly enhanced in nitrogen and depleted in carbon and oxygen, evidence for CNO processed material.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014NewA...28...23K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014NewA...28...23K"><span id="translatedtitle">First BVR light curves and preliminary results of a recently discovered W UMa-type binary: V1848 <span class="hlt">Ori</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kriwattanawong, W.; Poojon, P.</p> <p>2014-04-01</p> <p>First complete photometric light curves of a recently discovered contact binary, V1848 <span class="hlt">Ori</span>, are presented. BVR imaging data were used to derive photometric solutions, using Wilson-Devinney code. We discovered that this system is a weak-contact binary, with a fillout factor of f = 13.14%(1.44%). Preliminary results showed that V1848 <span class="hlt">Ori</span> is an A-type W UMa system, with a mass ratio of q = 0.7615. The more massive component was found about 400 K hotter than the other one. This system has varied from W-type to A-type during the last decade. According to the preliminary physical parameters, the weak-contact configuration of this system, with the mass ratio close to unity, and no sign of long-term orbital period change yet, is unlikely to be broken. The contact configuration is expected to be maintained and become deeper or not, depending on effect of the AML mechanism.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3733188','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3733188"><span id="translatedtitle">The Combating Obesity in Mā<span class="hlt">ori</span> and Pasifika Adolescent School-Children Study: COMPASS Methodology and Study Protocol</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Stoner, Lee; Shultz, Sarah P.; Lambrick, Danielle M.; Krebs, Jeremy; Weatherall, Mark; Palmer, Barry R.; Lane, Andrew M.; Kira, Geoff; Witter, Trevor; Williams, Michelle A.</p> <p>2013-01-01</p> <p>Background: Lifestyle modifications including, physical activity can reduce obesity-related morbidity and subsequent cardiovascular disease in youth. This study will investigate the efficacy of a culturally-sensitive, non-contact, boxing-orientated training program on obesity and related cardio-metabolic conditions in Mā<span class="hlt">ori</span> and Pasifika adolescents. Details of the methodological aspects of recruitment, inclusion criteria, randomization, cultural sensitivity, intervention program, assessments, process evaluation, and statistical analyses are described. Methods: This study will be a community based, New Zealand, randomized control trial (RCT). Male and female obese (body mass index >95th percentile) Mā<span class="hlt">ori</span> and Pasifika adolescents aged 14-16 years will be recruited and the sample size will be confirmed through a feasibility study. Combating Obesity in Mā<span class="hlt">ori</span> and Pasifika Adolescent School-children Study (COMPASS) is a 6-month, theory-based program, conducted 3-times/week in a culturally appropriate setting. Each session includes 40 min boxing-orientated training and 30 min resistance training. Assessments will be made at baseline, 3-months, 6-months, 12-months, and 24-months. Main outcomes include abdominal obesity, endothelial function, and insulin resistance. Other outcomes include arterial stiffness, lipid profile, inflammatory biomarkers, well-being, and aerobic fitness. Control measures include physical activity, sleep behavior, and dietary intake. Results: As a protocol paper there are no specific results to present, our purpose is to share our RCT design with the scientific community. Conclusions: COMPASS will be used to provide direction for exercise prescription policy in at-risk Mā<span class="hlt">ori</span> and Pasifika adolescents. PMID:23930168</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016AAS...22734305C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016AAS...22734305C"><span id="translatedtitle">ALMA Early Science Observations of Outbursting Stellar Systems:Disk Masses for FU <span class="hlt">Ori</span> and EXor Objects</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Cieza, Lucas A.; Prieto, Jose Luis; Zhu, Zhaohuan; Tobin, John J.; Williams, Jonathan P.; Hales, Antonio; Casassus, Simon; Principe, David; Schreiber, Matthias R.</p> <p>2016-01-01</p> <p>It is believed that low-mass stars build a significant fraction of their total mass during short outbursts of enhanced accretion (up to 10E-4 MSOLAR /yr). The most dramatic episodic accretion events known in Young Stellar Objects (YSOs) are FU <span class="hlt">Ori</span> and EXor outbursts. FU <span class="hlt">Ori</span> objects are characterized by a sudden brightening of 5 magnitudes or more within one year and remain bright for decades. EXor objects have lower amplitude outbursts on shorter timescales (months to years). Here we present an ALMA 230 GHz (1.3 mm / band-6) mini-survey of 8 outbursting sources (three FU <span class="hlt">Ori</span> and ve EXor objects) in Orion with 1" (450 AU) resolution. We present continuum, 12CO, 13CO, and C18O line images and derive dust and (when possible) gas disk masses. The disk masses derived from the line observations are systematically lower (by factors of 3-5) than those calculated from the continuum and adopting the standard gas-to-dust ratio of 100, which agrees with results on T Tauri disks in Taurus. After beam deconvolution, we nd that the disks are remarkably compact (r = 70-150 AU). The 1.3 mm fuxes of the outbursting sources span over three orders of magnitude, but the FU <span class="hlt">Ori</span> objects are signi cantly brighter than the EXor objects. The inferred disk masses for the brightest objects are > 0.1 Msolar , rendering gravitational instability a likely outburst mechanism. On the other hand, the inferred disk masses for the faintest targets are ~ 1-5 MJUP , and thus an alternative mechanism must be responsible for their outbursts.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26267565','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26267565"><span id="translatedtitle">Functional Sharing of the Upper Orbicularis <span class="hlt">Oris</span> Muscle for the Reconstruction of the Lower Lip.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Yazar, Memet; Yazar, Sevgi Kurt; Kozanoğlu, Erol; Karsidag, Semra</p> <p>2015-09-01</p> <p>The lip reconstruction is a very controversial topic in plastic surgery and many flaps have been described for this purpose. Despite all of the interventions, some patients still have problems such as drooling and gingival show that decrease their quality of life. In this study, the authors report a patient whose lower lip was resected totally for squamous cell carcinoma. His lip was reconstructed with radial forearm flap and the patient was referred to our clinic with the aforementioned complaints. A portion of the orbicularis <span class="hlt">oris</span> muscle of the upper lip was designed as a bipedicled flap, and it was transposed to the lower lip to make the initial flap functional. After the operation, the sphincteric function of the lip was better, and the problems as drooling and gingival show were absent. In conclusion, this flap can be a good option to make the initial nonfunctional flaps (such as radial forearm flap), functional in the aspect of lower lip reconstruction. It has a function, and it is concordant with the principle of "reconstructing like with like." The native muscle tissue of the upper lip can be transferred partially to maintain physiologic oral competency. PMID:26267565</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016ApJ...819L...5G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016ApJ...819L...5G"><span id="translatedtitle">On the 2015 Outburst of the EXor Variable V1118 <span class="hlt">Ori</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Giannini, T.; Lorenzetti, D.; Antoniucci, S.; Arkharov, A. A.; Larionov, V. M.; Di Paola, A.; Bisogni, S.; Marchetti, A.</p> <p>2016-03-01</p> <p>After a long-lasting period of quiescence of about a decade, the source V1118 <span class="hlt">Ori</span>, one of the most representative members of the EXor variables, is now outbursting. Since the initial increase of the near-infrared flux of about 1 mag (JHK bands) registered on 2015 September 22, the source brightness has remained fairly stable. We estimate ΔV ∼ 3 mag, with respect to the quiescence phase. An optical/near-IR low-resolution spectrum has been obtained with the Large Binocular Telescope instruments MODS and LUCI2 and compared with a spectrum of a similar spectral resolution and sensitivity level taken during quiescence. Together with the enhancement of the continuum, the outburst spectrum presents a definitely higher number of emission lines, in particular H i recombination lines of the Balmer, Paschen, and Brackett series, along with bright permitted lines of several species, forbidden atomic lines, and CO ro-vibrational lines. Both mass accretion and mass-loss rates have significantly increased (by about an order of magnitude: {\\dot{M}}{acc} = 1.2–4.8 10‑8 M⊙ yr‑1, {\\dot{M}}{loss} = 0.8–2 10‑9 M⊙ yr‑1), with respect to the quiescence phase. If compared with previous outbursts, the present one appears less energetic. Alternatively, it could already be in the fading phase (with the maximum brightness level reached when the source was not visible), or, viceversa, still in the rising phase.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/22494506','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/22494506"><span id="translatedtitle">The 'warrior gene' and the Mã<span class="hlt">ori</span> people: the responsibility of the geneticists.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Perbal, Laurence</p> <p>2013-09-01</p> <p>The 'gene of' is a teleosemantic expression that conveys a simplistic and linear relationship between a gene and a phenotype. Throughout the 20th century, geneticists studied these genes of traits. The studies were often polemical when they concerned human traits: the 'crime gene', 'poverty gene', 'IQ gene', 'gay gene' or 'gene of alcoholism'. Quite recently, a controversy occurred in 2006 in New Zealand that started with the claim that a 'warrior gene' exists in the Mã<span class="hlt">ori</span> community. This claim came from a geneticist working on the MAOA gene. This article is interested in the responsibility of that researcher regarding the origin of the controversy. Several errors were made: overestimation of results, abusive use of the 'gene of' kind of expression, poor communication with the media and a lack of scientific culture. The issues of the debate were not taken into account sufficiently, either from the political, social, ethical or even the genetic points of view. After more than 100 years of debates around 'genes of' all kinds (here, the 'warrior gene'), geneticists may not hide themselves behind the media when a controversy occurs. Responsibilities have to be assumed. PMID:22494506</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015yCat..74441793D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015yCat..74441793D"><span id="translatedtitle">VizieR Online Data Catalog: 25 <span class="hlt">Ori</span> group low-mass stars (Downes+, 2014)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Downes, J. J.; Briceno, C.; Mateu, C.; Hernandez, J.; Vivas, A. K.; Calvet, N.; Hartmann, L.; Petr-Gotzens, M. G.; Allen, L.</p> <p>2015-04-01</p> <p>Multi-epoch optical V-, R-, I-band and Hα observations across the entire Orion OB1 association (spanning ~180deg2) were obtained as part of the CVSO (Briceno et al., 2005AJ....129..907B, Cat. J/AJ/129/907), being conducted since 1998 with the Jurgen Stock 1.0/1.5 Schmidt-type telescope and the 8000x8000-pixel QUEST-I CCD Mosaic camera, at the National Astronomical Observatory of Venezuela. During 2009 a new dedicated 4m survey telescope, the Visible and Infrared Survey Telescope for Astronomy (VISTA), located at ESO's Paranal Observatory, was commissioned by the VISTA consortium. For the Galactic Science Verification of VISTA, an ~30deg2 area of the Orion OB1 association, which included the Orion Belt region, part of the Orion A cloud, the 25 Orionis and σ <span class="hlt">Ori</span> clusters, was imaged in the Z, Y, J, H and Ks filters, during 2009 October 16 to November 2. (3 data files).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/10699185','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/10699185"><span id="translatedtitle">Expression of the human CFTR gene from episomal <span class="hlt">ori</span>P-EBNA1-YACs in mouse cells.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Huertas, D; Howe, S; McGuigan, A; Huxley, C</p> <p>2000-03-01</p> <p>Plasmids carrying the origin of plasmid replication ( <span class="hlt">ori</span>P ) and expressing the EBNA-1 protein from the Epstein-Barr virus replicate and segregate in human cells and are thus potentially useful vectors for gene therapy. As very large circular molecules, up to 660 kb in size, can be maintained episomally using this system, it is possible to include intact human genes with all their long-range controlling elements which might give high levels of tissue-specific and controlled gene expression. We have shown previously that a 320 kb yeast artificial chromosome (YAC) carrying the intact human CFTR gene can complement the Cambridge null cystic fibrosis mice as a transgene. We have now modified this YAC to a circular molecule carrying both <span class="hlt">ori</span>P and the EBNA-1 gene. We show that this <span class="hlt">ori</span>P-EBNA1-YAC can be stably maintained as unrearranged episomes in mouse LA-9 cells, which do not express endogenous cftr, and in mouse CMT-93 cells, which do express endogenous cftr. The human CFTR gene is expressed in some of the cell lines, but the level of expression is very variable between cell lines and is not related to the copy number of the elements. PMID:10699185</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26755532','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26755532"><span id="translatedtitle">Interkingdom cooperation between Candida albicans, Streptococcus oralis and Actinomyces <span class="hlt">oris</span> modulates early biofilm development on denture material.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cavalcanti, Indira M G; Nobbs, Angela H; Ricomini-Filho, Antônio Pedro; Jenkinson, Howard F; Del Bel Cury, Altair A</p> <p>2016-04-01</p> <p>Candida-associated stomatitis affects up to 60% of denture wearers, and Candida albicans remains the most commonly isolated fungal species. The oral bacteria Actinomyces <span class="hlt">oris</span> and Streptococcus oralis are abundant in early dental plaque. The aims of this study were to determine the effects of S. oralis and A. <span class="hlt">oris</span> on the development of C. albicans biofilms on denture material. Resin discs were coated with saliva and at early (1.5 h) or later (24 h) stages of biofilm development, cell numbers of each species were determined. Spatial distribution of microorganisms was visualized by confocal scanning laser microscopy of biofilms labelled by differential fluorescence or by fluorescence in situ hybridization. Interkingdom interactions underpinning biofilm development were also evaluated planktonically utilizing fluorescence microscopy. Synergistic interactions between all three species occurred within biofilms and planktonically. Bacterial cells coaggregated with each other and adhered singly or in coaggregates to C. albicans hyphal filaments. Streptococcus oralis appeared to enhance hyphal filament production and C. albicans biovolume was increased 2-fold. Concomitantly, cell numbers of S. oralis and A. <span class="hlt">oris</span> were enhanced by C. albicans. Thus, cooperative physical and metabolic processes occurring between these three microbial species intensify pathogenic plaque communities on denture surfaces. PMID:26755532</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li class="active"><span>7</span></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_7 --> <div id="page_8" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li class="active"><span>8</span></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="141"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=7499339&dopt=AbstractPlus','TOXNETTOXLINE'); return false;" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=7499339&dopt=AbstractPlus"><span id="translatedtitle">The traY gene product and integration host factor stimulate Escherichia coli DNA helicase I-catalyzed nicking at the F plasmid <span class="hlt">ori</span>T.</span></a></p> <p><a target="_blank" href="http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?TOXLINE">TOXLINE Toxicology Bibliographic Information</a></p> <p>Nelson WC; Howard MT; Sherman JA; Matson SW</p> <p>1995-11-24</p> <p>F plasmid conjugative transfer is initiated by the introduction of a site- and strand-specific nick within the plasmid origin of transfer (<span class="hlt">ori</span>T). Genetic studies have shown nick formation to be dependent on both the traI and traY genes. However, highly purified TraIp, the traI gene product, nicks <span class="hlt">ori</span>T in a site- and strand-specific manner in the absence of the traY gene product (TraYp) in vitro (Matson, S.W., and Morton, B.S. (1991) J. Biol. Chem. 266, 16232-16237). Analysis of the <span class="hlt">ori</span>T region has revealed binding sites for TraYp and the host protein integration host factor (IHF). To explore possible interactions occurring at <span class="hlt">ori</span>T, highly purified TraIp, TraYp, and IHF were incubated with a supercoiled <span class="hlt">ori</span>T-containing DNA substrate. A marked enhancement of the nicking reaction catalyzed by TraIp was observed in a reaction that required both TraYp and IHF. In addition, TraIp was able to nick a linear <span class="hlt">ori</span>T-containing double-stranded DNA substrate when IHF and TraYp were present in the reaction; such a substrate is not nicked by TraIp alone. Individual protein concentration requirements for the supercoiled and linear nicking reactions were similar, and the reactions occurred at equal velocity, suggesting that they are biochemically identical. Concentrations of TraYp and IHF that yield half-maximal activity in the nicking assays compare well with the reported KD values for the IHF and TraYp binding sites in <span class="hlt">ori</span>T. These data, coupled with data presented in the accompanying report, suggest that TraYp and IHF bind independent of one another, forming a nucleo-protein complex with <span class="hlt">ori</span>T that can be recognized and nicked by TraIp.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/7499339','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/7499339"><span id="translatedtitle">The traY gene product and integration host factor stimulate Escherichia coli DNA helicase I-catalyzed nicking at the F plasmid <span class="hlt">ori</span>T.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nelson, W C; Howard, M T; Sherman, J A; Matson, S W</p> <p>1995-11-24</p> <p>F plasmid conjugative transfer is initiated by the introduction of a site- and strand-specific nick within the plasmid origin of transfer (<span class="hlt">ori</span>T). Genetic studies have shown nick formation to be dependent on both the traI and traY genes. However, highly purified TraIp, the traI gene product, nicks <span class="hlt">ori</span>T in a site- and strand-specific manner in the absence of the traY gene product (TraYp) in vitro (Matson, S.W., and Morton, B.S. (1991) J. Biol. Chem. 266, 16232-16237). Analysis of the <span class="hlt">ori</span>T region has revealed binding sites for TraYp and the host protein integration host factor (IHF). To explore possible interactions occurring at <span class="hlt">ori</span>T, highly purified TraIp, TraYp, and IHF were incubated with a supercoiled <span class="hlt">ori</span>T-containing DNA substrate. A marked enhancement of the nicking reaction catalyzed by TraIp was observed in a reaction that required both TraYp and IHF. In addition, TraIp was able to nick a linear <span class="hlt">ori</span>T-containing double-stranded DNA substrate when IHF and TraYp were present in the reaction; such a substrate is not nicked by TraIp alone. Individual protein concentration requirements for the supercoiled and linear nicking reactions were similar, and the reactions occurred at equal velocity, suggesting that they are biochemically identical. Concentrations of TraYp and IHF that yield half-maximal activity in the nicking assays compare well with the reported KD values for the IHF and TraYp binding sites in <span class="hlt">ori</span>T. These data, coupled with data presented in the accompanying report, suggest that TraYp and IHF bind independent of one another, forming a nucleo-protein complex with <span class="hlt">ori</span>T that can be recognized and nicked by TraIp. PMID:7499339</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23598996','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23598996"><span id="translatedtitle">Din7 and Mhr1 expression levels regulate double-strand-break-induced replication and recombination of mtDNA at <span class="hlt">ori</span>5 in yeast.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ling, Feng; Hori, Akiko; Yoshitani, Ayako; Niu, Rong; Yoshida, Minoru; Shibata, Takehiko</p> <p>2013-06-01</p> <p>The Ntg1 and Mhr1 proteins initiate rolling-circle mitochondrial (mt) DNA replication to achieve homoplasmy, and they also induce homologous recombination to maintain mitochondrial genome integrity. Although replication and recombination profoundly influence mitochondrial inheritance, the regulatory mechanisms that determine the choice between these pathways remain unknown. In Saccharomyces cerevisiae, double-strand breaks (DSBs) introduced by Ntg1 at the mitochondrial replication origin <span class="hlt">ori</span>5 induce homologous DNA pairing by Mhr1, and reactive oxygen species (ROS) enhance production of DSBs. Here, we show that a mitochondrial nuclease encoded by the nuclear gene DIN7 (DNA damage inducible gene) has 5'-exodeoxyribonuclease activity. Using a small ?(-) mtDNA bearing <span class="hlt">ori</span>5 (hypersuppressive; HS) as a model mtDNA, we revealed that DIN7 is required for ROS-enhanced mtDNA replication and recombination that are both induced at <span class="hlt">ori</span>5. Din7 overproduction enhanced Mhr1-dependent mtDNA replication and increased the number of residual DSBs at <span class="hlt">ori</span>5 in HS-?(-) cells and increased deletion mutagenesis at the <span class="hlt">ori</span>5 region in ?(+) cells. However, simultaneous overproduction of Mhr1 suppressed all of these phenotypes and enhanced homologous recombination. Our results suggest that after homologous pairing, the relative activity levels of Din7 and Mhr1 modulate the preference for replication versus homologous recombination to repair DSBs at <span class="hlt">ori</span>5. PMID:23598996</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3675488','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3675488"><span id="translatedtitle">Din7 and Mhr1 expression levels regulate double-strand-breakinduced replication and recombination of mtDNA at <span class="hlt">ori</span>5 in yeast</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ling, Feng; Hori, Akiko; Yoshitani, Ayako; Niu, Rong; Yoshida, Minoru; Shibata, Takehiko</p> <p>2013-01-01</p> <p>The Ntg1 and Mhr1 proteins initiate rolling-circle mitochondrial (mt) DNA replication to achieve homoplasmy, and they also induce homologous recombination to maintain mitochondrial genome integrity. Although replication and recombination profoundly influence mitochondrial inheritance, the regulatory mechanisms that determine the choice between these pathways remain unknown. In Saccharomyces cerevisiae, double-strand breaks (DSBs) introduced by Ntg1 at the mitochondrial replication origin <span class="hlt">ori</span>5 induce homologous DNA pairing by Mhr1, and reactive oxygen species (ROS) enhance production of DSBs. Here, we show that a mitochondrial nuclease encoded by the nuclear gene DIN7 (DNA damage inducible gene) has 5?-exodeoxyribonuclease activity. Using a small ?? mtDNA bearing <span class="hlt">ori</span>5 (hypersuppressive; HS) as a model mtDNA, we revealed that DIN7 is required for ROS-enhanced mtDNA replication and recombination that are both induced at <span class="hlt">ori</span>5. Din7 overproduction enhanced Mhr1-dependent mtDNA replication and increased the number of residual DSBs at <span class="hlt">ori</span>5 in HS-?? cells and increased deletion mutagenesis at the <span class="hlt">ori</span>5 region in ?+ cells. However, simultaneous overproduction of Mhr1 suppressed all of these phenotypes and enhanced homologous recombination. Our results suggest that after homologous pairing, the relative activity levels of Din7 and Mhr1 modulate the preference for replication versus homologous recombination to repair DSBs at <span class="hlt">ori</span>5. PMID:23598996</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/20634889','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/20634889"><span id="translatedtitle">Role for a region of helically unstable DNA within the Epstein-Barr virus latent cycle origin of DNA replication <span class="hlt">ori</span>P in origin function</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Polonskaya, Zhanna; Benham, Craig J.; Hearing, Janet . E-mail: jhearing@ms.cc.sunysb.edu</p> <p>2004-10-25</p> <p>The minimal replicator of the Epstein-Barr virus (EBV) latent cycle origin of DNA replication <span class="hlt">ori</span>P is composed of two binding sites for the Epstein-Barr virus nuclear antigen-1 (EBNA-1) and flanking inverted repeats that bind the telomere repeat binding factor TRF2. Although not required for minimal replicator activity, additional binding sites for EBNA-1 and TRF2 and one or more auxiliary elements located to the right of the EBNA-1/TRF2 sites are required for the efficient replication of <span class="hlt">ori</span>P plasmids. Another region of <span class="hlt">ori</span>P that is predicted to be destabilized by DNA supercoiling is shown here to be an important functional component of <span class="hlt">ori</span>P. The ability of DNA fragments of unrelated sequence and possessing supercoiled-induced DNA duplex destabilized (SIDD) structures, but not fragments characterized by helically stable DNA, to substitute for this component of <span class="hlt">ori</span>P demonstrates a role for the SIDD region in the initiation of <span class="hlt">ori</span>P-plasmid DNA replication.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4790504','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4790504"><span id="translatedtitle">Whakawhanaungatanga: the importance of culturally meaningful connections to improve uptake of pulmonary rehabilitation by Mā<span class="hlt">ori</span> with COPD – a qualitative study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Levack, William MM; Jones, Bernadette; Grainger, Rebecca; Boland, Pauline; Brown, Melanie; Ingham, Tristram R</p> <p>2016-01-01</p> <p>Background Pulmonary rehabilitation is known to improve function and quality of life for people with chronic obstructive pulmonary disease (COPD). However, little research has been conducted on the influence of culture on experiences of pulmonary rehabilitation. This study examined factors influencing uptake of pulmonary rehabilitation by Mā<span class="hlt">ori</span> with COPD in New Zealand. Method Grounded theory nested within kaupapa Mā<span class="hlt">ori</span> methodology. Transcripts were analyzed from interviews and focus groups with 15 Mā<span class="hlt">ori</span> and ten New Zealand non-Mā<span class="hlt">ori</span> invited to attend pulmonary rehabilitation for COPD. Mā<span class="hlt">ori</span> participants had either attended a mainstream hospital-based program, a community-based program designed “by Mā<span class="hlt">ori</span>, for Māori”, or had experienced both. Results Several factors influencing uptake of pulmonary rehabilitation were common to all participants regardless of ethnicity: 1) participants’ past experiences (eg, of exercise; of health care systems), 2) attitudes and expectations, 3) access issues (eg, time, transport, and conflicting responsibilities), and 4) initial program experiences. These factors were moderated by the involvement of family and peers, interactions with health professionals, the way information on programs was presented, and by new illness events. For Mā<span class="hlt">ori</span>, however, several additional factors were also identified relating to cultural experiences of pulmonary rehabilitation. In particular, Mā<span class="hlt">ori</span> participants placed high value on whakawhanaungatanga: the making of culturally meaningful connections with others. Culturally appropriate communication and relationship building was deemed so important by some Mā<span class="hlt">ori</span> participants that when it was absent, they felt strongly discouraged to attend pulmonary rehabilitation. Only the more holistic services offered a program in which they felt culturally safe and to which they were willing to return for ongoing rehabilitation. Conclusion Lack of attention to cultural factors in the delivery of pulmonary rehabilitation may be a barrier to its uptake by indigenous, minority ethnic groups, such as New Zealand Mā<span class="hlt">ori</span>. Indigenous-led or culturally responsive health care interventions for COPD may provide a solution to this issue.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015ApJ...808...88R','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015ApJ...808...88R"><span id="translatedtitle">HST/STIS Ultraviolet Spectroscopy of the Components of the Massive Triple Star δ <span class="hlt">Ori</span> A</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Richardson, Noel D.; Moffat, Anthony F. J.; Gull, Theodore R.; Lindler, Don J.; Gies, Douglas R.; Corcoran, Michael F.; Chené, André-Nicolas</p> <p>2015-07-01</p> <p>The multiple star system of δ Orionis is one of the closest examples of a system containing a luminous O-type, bright giant star (component Aa1). It is often used as a spectral-type standard and has the highest observed X-ray flux of any hot-star binary. The main component Aa1 is orbited by two lower mass stars, faint Aa2 in a 5.7 day eclipsing binary, and Ab, an astrometric companion with an estimated period of 346 years. Generally the flux from all three stars is recorded in ground-based spectroscopy, and the spectral decomposition of the components has proved difficult. Here we present Hubble Space Telescope/Space Telescope Imaging Spectrograph ultraviolet spectroscopy of δ <span class="hlt">Ori</span> A that provides us with spatially separated spectra of Aa and Ab for the first time. We measured radial velocities for Aa1 and Ab in two observations made near the velocity extrema of Aa1. We show tentative evidence for the detection of the Aa2 component in cross-correlation functions of the observed and model spectra. We discuss the appearance of the UV spectra of Aa1 and Ab with reference to model spectra. Both stars have similar effective temperatures, but Ab is fainter and is a rapid rotator. The results will help in the interpretation of ground-based spectroscopy and in understanding the physical and evolutionary parameters of these massive stars. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are associated with program #13450.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005AJ....129..907B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005AJ....129..907B"><span id="translatedtitle">The CIDA Variability Survey of Orion OB1. I. The Low-Mass Population of <span class="hlt">Ori</span> OB1a and 1b</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Briceo, Cesar; Calvet, Nuria; Hernndez, J.; Vivas, A. K.; Hartmann, Lee; Downes, J. J.; Berlind, Perry</p> <p>2005-02-01</p> <p>We present results of a large-scale, multiepoch optical survey of the Orion OB1 association, carried out with the QUEST camera at the Venezuela National Astronomical Observatory. We identify for the first time the widely spread low-mass, young population in the <span class="hlt">Ori</span> OB1a and OB1b subassociations. Candidate members were picked up by their variability in the V band and position in color-magnitude diagrams. We obtained spectra to confirm membership. In a region spanning ~68 deg2, we found 197 new young stars; of these, 56 are located in the <span class="hlt">Ori</span> OB1a subassociation and 141 in <span class="hlt">Ori</span> OB1b. The spatial distribution of the low-mass young stars is spatially coincident with that of the high-mass members but suggests a much sharper edge to the association. Comparison with the spatial extent of molecular gas and extinction maps indicates that the subassociation <span class="hlt">Ori</span> OB1b is concentrated within a ringlike structure of radius ~2(~15 pc at 440 pc), centered roughly on the star ? <span class="hlt">Ori</span> in the Orion belt. The ring is apparent in 13CO and corresponds to a region with an extinction AV>=1. The stars exhibiting strong H? emission, an indicator of active accretion, are found along this ring, whereas the center is populated with weak H?-emitting stars. In contrast, <span class="hlt">Ori</span> OB1a is located in a region devoid of gas and dust. We identify a grouping of stars within a ~3 deg2 area located in <span class="hlt">Ori</span> OB1a, roughly clustered around the B2 star 25 <span class="hlt">Ori</span>. The Herbig Ae/Be star V346 <span class="hlt">Ori</span> is also associated with this grouping, which could be an older analog of ? <span class="hlt">Ori</span>. Using several sets of evolutionary tracks, we find an age of 7-10 Myr for <span class="hlt">Ori</span> OB1a and of ~4-6 Myr for <span class="hlt">Ori</span> OB1b, consistent with previous estimates from OB stars. Indicators such as the equivalent width of H? and near-IR excesses show that the number of accreting low-mass stars decreases sharply between <span class="hlt">Ori</span> OB1b and <span class="hlt">Ori</span> OB1a. These results indicate that although a substantial fraction of accreting disks remain at ages ~5 Myr, inner disks are essentially dissipated by 10 Myr. Based on observations obtained at the Llano del Hato National Astronomical Observatory of Venezuela, operated by Centro de Investigaciones de Astronoma (CIDA) for the Ministerio de Ciencia y Tecnologa, and at the Fred Lawrence Whipple Observatory (FLWO) of the Smithsonian Institution. Based on observations obtained at the 3.5 m WIYN Telescope. The WIYN Observatory is a joint facility of the University of Wisconsin-Madison, Indiana University, Yale University, and the National Optical Astronomy Observatory (NOAO).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=204561','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=204561"><span id="translatedtitle">Characterization of the reaction product of the <span class="hlt">ori</span>T nicking reaction catalyzed by Escherichia coli DNA helicase I.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Matson, S W; Nelson, W C; Morton, B S</p> <p>1993-01-01</p> <p>DNA helicase I, encoded on the Escherichia coli F plasmid, catalyzes a site- and strand-specific nicking reaction within the F plasmid origin of transfer (<span class="hlt">ori</span>T) to initiate conjugative DNA strand transfer. The product of the nicking reaction contains a single phosphodiester bond interruption as determined by single-nucleotide resolution mapping of both sides of the nick site. This analysis has demonstrated that the nick is located at precisely the same site previously shown to be nicked in vivo (T. L. Thompson, M. B. Centola, and R. C. Deonier, J. Mol. Biol. 207:505-512, 1989). In addition, studies with two <span class="hlt">ori</span>T point mutants have confirmed the specificity of the in vitro reaction. Characterization of the nicked DNA product has revealed a modified 5' end and a 3' OH available for extension by E. coli DNA polymerase I. Precipitation of nicked DNA with cold KCl in the presence of sodium dodecyl sulfate suggests the existence of protein covalently attached to the nicked DNA molecule. The covalent nature of this interaction has been directly demonstrated by transfer of radiolabeled phosphate from DNA to protein. On the basis of these results, we propose that helicase I becomes covalently bound to the 5' end of the nicked DNA strand as part of the reaction mechanism for phosphodiester bond cleavage. A model is presented to suggest how helicase I could nick the F plasmid at <span class="hlt">ori</span>T and subsequently unwind the duplex DNA to provide single-stranded DNA for strand transfer during bacterial conjugation. Images PMID:8386720</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015AJ....150...37Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015AJ....150...37Z"><span id="translatedtitle">The Nature of V392 <span class="hlt">Ori</span>: A Near-contact Binary with a ? Scuti-type Component</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zhang, X. B.; Luo, Y. P.; Wang, K.; Luo, C. Q.</p> <p>2015-07-01</p> <p>This study presents multi-color photometric observations of the short-period eclipsing binary V392 <span class="hlt">Ori</span>. Taking into account the results obtained from the models and analyses of the BVRI light curves, the nature of the binary system as well as the light-curve variations were discussed. The distortions of the light curves were successfully synthesized with a cool-spot model. The photometric solutions indicated that V392 <span class="hlt">Ori</span> is a semi-detached, near-contact system with the cooler secondary component filling and the primary nearly filling each of their Roche lobes. The mass ratio of the system is determined to be 0.247 0.001, and the inclination is derived to be 79\\buildrel{\\circ}\\over{.} 85+/- 0\\buildrel{\\circ}\\over{.} 03. Based on these results, the physical parameters of the components were estimated. The O-C analysis indicates that the secular orbital period of the system is decreasing at a rate of ?3.0 s per century, probably due to the nonconservative mass exchange and mass loss of the system, which could be the source of the long-term light-curve changes. By subtracting the theoretical light curves from the original observations, we remove the eclipse and proximity effects so as to investigate the short-term variations. Frequency analysis of the residual light reveals a periodicity of 35.5 minutes in all the BVRI bands. The nature of the intrinsic pulsations was discussed along with the evolution of the components. For the first time in the literature, we revealed that the primary component is a ? Scuti star. We thus list V392 <span class="hlt">Ori</span> as a new candidate eclipsing binary with a ? Scuti component.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20130011908','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20130011908"><span id="translatedtitle">X-Raying the Beating Heart of a Newborn Star: Rotational Modulation of High-Energy Radiation from V1647 <span class="hlt">Ori</span></span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Hamaguchi, Kenji; Grosso, Nicolas; Kastner, Joel H.; Weintraub, David A.; Richmond, Michael; Petre, Robert; Teets, William K.; Principe, David</p> <p>2012-01-01</p> <p>We report a periodicity of approx.1 day in the highly elevated X-ray emission from the protostar V1647 <span class="hlt">Ori</span> during its two recent multiple-year outbursts of mass accretion. This periodicity is indicative of protostellar rotation at near-breakup speed. Modeling of the phased X-ray light curve indicates the high-temperature ( 50 MK), X-ray-emitting plasma, which is most likely heated by accretion-induced magnetic reconnection, resides in dense ( 5 1010 cm.3), pancake-shaped magnetic footprints where the accretion stream feeds the newborn star. The sustained X-ray periodicity of V1647 <span class="hlt">Ori</span> demonstrates that such protostellar magnetospheric accretion configurations can be stable over timescales of years. Subject headings: stars: formation stars: individual (V1647 <span class="hlt">Ori</span>) stars: pre-main sequence X-rays: stars</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=47399','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=47399"><span id="translatedtitle">Decatenation activity of topoisomerase IV during <span class="hlt">ori</span>C and pBR322 DNA replication in vitro.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Peng, H; Marians, K J</p> <p>1993-01-01</p> <p>Topoisomerase IV (Topo IV), encoded by parC and parE, is required for partition of the daughter chromosomes in Escherichia coli. This enzyme is likely responsible for decatenating the linked daughter chromosomes after replication. In this report, we have examined the action of Topo IV in both pBR322 and <span class="hlt">ori</span>C DNA replication reconstituted in vitro with purified proteins. Gyrase fails to decatenate the linked daughter molecules under any condition in the <span class="hlt">ori</span>C system and at physiological salt concentrations in the pBR322 system, whereas Topo IV stimulates generation of monomer product DNA by 7- to 10-fold. Topo IV-catalyzed decatenation of isolated multiply linked DNA dimers was relatively insensitive to salt; it proceeded at 14% of the maximal rate even in the presence of 800 mM potassium glutamate. In contrast, decatenation in vitro by gyrase was inhibited completely under these conditions. Pulse-chase analysis indicated that Topo IV-catalyzed resolution of linked daughter DNA molecules occurred prior to completion of DNA replication, such that multiply linked daughter molecules did not arise. These results suggest that during DNA replication, gyrase acts primarily to relieve accumulated positive supercoiling and Topo IV acts to segregate the daughter chromosomes. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 PMID:8104339</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25965671','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25965671"><span id="translatedtitle">Streptococcus gordonii DL1 adhesin SspB V-region mediates coaggregation via receptor polysaccharide of Actinomyces <span class="hlt">oris</span> T14V.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Back, C R; Douglas, S K; Emerson, J E; Nobbs, A H; Jenkinson, H F</p> <p>2015-10-01</p> <p>Streptococcus gordonii SspA and SspB proteins, members of the antigen I/II (AgI/II) family of Streptococcus adhesins, mediate adherence to cysteine-rich scavenger glycoprotein gp340 and cells of other oral microbial species. In this article we investigated further the mechanism of coaggregation between S. gordonii DL1 and Actinomyces <span class="hlt">oris</span> T14V. Previous mutational analysis of S. gordonii suggested that SspB was necessary for coaggregation with A. <span class="hlt">oris</span> T14V. We have confirmed this by showing that Lactococcus lactis surrogate host cells expressing SspB coaggregated with A. <span class="hlt">oris</span> T14V and PK606 cells, while L. lactis cells expressing SspA did not. Coaggregation occurred independently of expression of A. <span class="hlt">oris</span> type 1 (FimP) or type 2 (FimA) fimbriae. Polysaccharide was prepared from cells of A. <span class="hlt">oris</span> T14V and found to contain 1,4-, 4,6- and 3,4-linked glucose, 1,4-linked mannose, and 2,4-linked galactose residues. When immobilized onto plastic wells this polysaccharide supported binding of L. lactis expressing SspB, but not binding of L. lactis expressing other AgI/II family proteins. Purified recombinant NAVP region of SspB, comprising amino acid (aa) residues 41-847, bound A. <span class="hlt">oris</span> polysaccharide but the C-domain (932-1470 aa residues) did not. A site-directed deletion of 29 aa residues (?691-718) close to the predicted binding cleft within the SspB V-region ablated binding of the NAVP region to polysaccharide. These results infer that the V-region head of SspB recognizes an actinomyces polysaccharide ligand, so further characterizing a lectin-like coaggregation mechanism occurring between two important primary colonizers. PMID:25965671</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/10572291','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/10572291"><span id="translatedtitle">Cellular localization of <span class="hlt">ori</span>C during the cell cycle of Escherichia coli as analyzed by fluorescent in situ hybridization.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Roos, M; van Geel, A B; Aarsman, M E; Veuskens, J T; Woldringh, C L; Nanninga, N</p> <p>1999-01-01</p> <p>The origin of replication of Escherichia coli, <span class="hlt">ori</span>C, has been labeled by fluorescent in situ hybridization (FISH). The E. coli K12 strain was grown under steady state conditions with a doubling time of 79 min at 28 degrees C. Under these growth conditions DNA replication starts in the previous cell cycle at -33 min. At birth cells possess two origins which are visible as two separated foci in fully labeled cells. The number of foci increased with cell length. The distance of foci from the nearest cell pole has been measured in various length classes. The data suggest: i) that the two most outwardly located foci keep a constant distance to the cell pole and they therefore move apart gradually in line with cell elongation; and ii) that at the initiation of DNA replication the labeled origins occur near the center of prospective daughter cells. PMID:10572291</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2005AAS...207.7412A','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2005AAS...207.7412A"><span id="translatedtitle">The 2005 Accretion Outburst in V1118 <span class="hlt">Ori</span>: Evidence for A Spectral Change in X-rays</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Audard, M.; Gdel, M.; Skinner, S. L.; Briggs, K. R.; Walter, F. M.; Stringfellow, G.; Hamilton, R. T.; Guinan, E. F.</p> <p>2005-12-01</p> <p>We present results from our X-ray monitoring campaign of the 2005 accretion outburst in the young low-mass star V1118 <span class="hlt">Ori</span>. Optical and near-infrared photometry are presented as well. The X-ray data from early 2005 indicate that the X-ray flux and luminosity varied within a factor of two only, and were similar to the pre-outburst values measured in a serendipitous observation in 2002. Similarly, the hydrogen column density showed no evidence for significant excursions from the pre-outburst value of a few times 1021 cm-2. However, we observed a spectral change from a dominant hot plasma ( 25 MK) in 2002 and in January 2005 to a cooler plasma ( 8 MK) in February and March 2005. We argue that the closing in of the accretion disk during the outburst disrupted the hot magnetic loops high in the corona, whereas the lower cooler loops were less affected and became the dominant coronal component. We acknowledge support by NASA through Chandra award DD5-6029X and through XMM-Newton award NNG05GI96G to Columbia University. The Chandra X-ray Observatory Center is operated by the Smithsonian Astrophysical Observatory for and on behalf of the NASA under contract NAS8-03060. Based on observations obtained with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA Member States and NASA. The PSI group acknowledges support from the Swiss National Science Foundation (grants 20-58827.99 and 20-66875.01). Stony Brook's participation in SMARTS is made possible by support from the offices of the Provost and the Vice President for Research. We thank J. Allyn Smith, P. McGehee, J. Espinoza, and D. Gonzalez for doing the observations with the SMARTS telescopes. We also thank H. Tannanbaum, N. Schartel, and the VLA TOO panel for granting time to observe V1118 <span class="hlt">Ori</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/22092435','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/22092435"><span id="translatedtitle">MULTIWAVELENGTH OBSERVATIONS OF V2775 <span class="hlt">Ori</span>, AN OUTBURSTING PROTOSTAR IN L 1641: EXPLORING THE EDGE OF THE FU ORIONIS REGIME</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Fischer, William J.; Megeath, S. Thomas; Kounkel, Marina; Tobin, John J.; Stutz, Amelia M.; Henning, Thomas; Ali, Babar; Stanke, Thomas; Osorio, Mayra; Wilson, T. L.</p> <p>2012-09-01</p> <p>Individual outbursting young stars are important laboratories for studying the physics of episodic accretion and the extent to which this phenomenon can explain the luminosity distribution of protostars. We present new and archival data for V2775 <span class="hlt">Ori</span> (HOPS 223), a protostar in the L 1641 region of the Orion molecular clouds that was discovered by Caratti o Garatti et al. to have recently undergone an order-of-magnitude increase in luminosity. Our near-infrared spectra of the source have strong blueshifted He I {lambda}10830 absorption, strong H{sub 2}O and CO absorption, and no H I emission, all typical of FU Orionis sources. With data from the Infrared Telescope Facility, the Two Micron All Sky Survey, the Hubble Space Telescope, Spitzer, the Wide-field Infrared Survey Explorer, Herschel, and the Atacama Pathfinder Experiment that span from 1 to 70 {mu}m pre-outburst and from 1 to 870 {mu}m post-outburst, we estimate that the outburst began between 2005 April and 2007 March. We also model the pre- and post-outburst spectral energy distributions of the source, finding it to be in the late stages of accreting its envelope with a disk-to-star accretion rate that increased from {approx}2 Multiplication-Sign 10{sup -6} M{sub Sun} yr{sup -1} to {approx}10{sup -5} M{sub Sun} yr{sup -1} during the outburst. The post-outburst luminosity at the epoch of the FU Orionis-like near-IR spectra is 28 L{sub Sun }, making V2775 <span class="hlt">Ori</span> the least luminous documented FU Orionis outburster with a protostellar envelope. The existence of low-luminosity outbursts supports the notion that a range of episiodic accretion phenomena can partially explain the observed spread in protostellar luminosities.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015MNRAS.451.2015O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015MNRAS.451.2015O"><span id="translatedtitle">Revisiting the rigidly rotating magnetosphere model for ? <span class="hlt">Ori</span> E - II. Magnetic Doppler imaging, arbitrary field RRM, and light variability</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Oksala, M. E.; Kochukhov, O.; Krti?ka, J.; Townsend, R. H. D.; Wade, G. A.; Prvk, M.; Mikulek, Z.; Silvester, J.; Owocki, S. P.</p> <p>2015-08-01</p> <p>The initial success of the Rigidly Rotating Magnetosphere (RRM) model application to the B2Vp star ? <span class="hlt">Ori</span> E by Townsend, Owocki & Groote triggered a renewed era of observational monitoring of this archetypal object. We utilize high-resolution spectropolarimetry and the magnetic Doppler imaging (MDI) technique to simultaneously determine the magnetic configuration, which is predominately dipolar, with a polar strength Bd = 7.3-7.8 kG and a smaller non-axisymmetric quadrupolar contribution, as well as the surface distribution of abundance of He, Fe, C, and Si. We describe a revised RRM model that now accepts an arbitrary surface magnetic field configuration, with the field topology from the MDI models used as input. The resulting synthetic H ? emission and broad-band photometric observations generally agree with observations, however, several features are poorly fit. To explore the possibility of a photospheric contribution to the observed photometric variability, the MDI abundance maps were used to compute a synthetic photospheric light curve to determine the effect of the surface inhomogeneities. Including the computed photospheric brightness modulation fails to improve the agreement between the observed and computed photometry. We conclude that the discrepancies cannot be explained as an effect of inhomogeneous surface abundance. Analysis of the UV light variability shows good agreement between observed variability and computed light curves, supporting the accuracy of the photospheric light variation calculation. We thus conclude that significant additional physics is necessary for the RRM model to acceptably reproduce observations of not only ? <span class="hlt">Ori</span> E, but also other similar stars with significant stellar wind-magnetic field interactions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/22199211','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/22199211"><span id="translatedtitle">Otariodibacter <span class="hlt">oris</span> gen. nov., sp. nov., a member of the family Pasteurellaceae isolated from the oral cavity of pinnipeds.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hansen, Mie Johanne; Bertelsen, Mads Frost; Christensen, Henrik; Bojesen, Anders Miki; Bisgaard, Magne</p> <p>2012-11-01</p> <p>A total of 27 bacterial isolates from California sea lions and a walrus tentatively classified within the family Pasteurellaceae was further characterized by genotypic and phenotypic tests. Phylogenetic analysis of partial 16S rRNA and rpoB gene sequences showed that the isolates investigated formed a monophyletic group, tentatively designated Bisgaard taxon 57. According to 16S rRNA gene sequences, the most closely related species with a validly published name was Bisgaardia hudsonensis and the most closely related species based on rpoB sequence comparison was Pasteurella multocida subsp. multocida; highest similarities between the isolates and the type strains of B. hudsonensis and P. multocida subsp. multocida were 95.0 and 88.2%. respectively. All isolates of Bisgaard taxon 57 exhibit the phenotypic characters of the family Pasteurellaceae. Members of Bisgaard taxon 57 can be separated from existing genera of the Pasteurellaceae by the following tests: positive reactions for catalase, oxidase, Voges-Proskauer and indole; no X- or V-factor dependency; and acid production from L-arabinose (slow), L-fucose, maltose and trehalose, but not from dulcitol, D-mannitol, D-mannose or sucrose. The main fatty acids of Bisgaard taxon 57 (CCUG 59994(T)) are C(14:0), C(16:0), C(16:1)?7c and the summed feature C(14:0) 3-OH/iso-C(16:1) I. This fatty acid profile is characteristic of members of the Pasteurellaceae. The quinone profile of Bisgaard taxon 57 (DSM 23800(T)) was similar to that of other genera in the Pasteurellaceae. The DNA G+C content of strain Baika1(T) is 36.2 mol%, which is at the lower end of the range for members of the family Pasteurellaceae. On the basis of both phylogenetic and phenotypic evidence, it is proposed that members of Bisgaard taxon 57 should be classified as representatives of a novel species in a new genus, Otariodibacter <span class="hlt">oris</span> gen. nov., sp. nov. The type strain of Otariodibacter <span class="hlt">oris</span> is Baika1(T) (=CCUG 59994(T)=DSM 23800(T)), which was isolated from the oral cavity of a healthy California sea lion in Copenhagen Zoo, Denmark, in 2007. PMID:22199211</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25743610','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25743610"><span id="translatedtitle">The fluid and electrolyte balance of New Zealand European and Mā<span class="hlt">ori</span>/Pacific Island athletes: An observational study.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>McLean, Andrew; Brown, Rachel Clare; Black, Katherine Elizabeth</p> <p>2016-04-01</p> <p>Observational research on professional athletes from the USA suggests differences may exist in sweat sodium loss based on ethnic differences. The New Zealand (NZ) sporting population is mainly of European or Mā<span class="hlt">ori</span>/Pacific Island origin. Therefore, this study aimed to describe the fluid-electrolyte balance of athletes by ethnicity. A total of 20 Mā<span class="hlt">ori</span>/Pacific Islanders (MP; body mass 100.97 ± 13.05 kg) and 29 NZ European (NZE; body mass 89.11 ± 11.56 kg) elite male athletes were recruited. Sweat rates were determined by body mass change during a 1-h spin cycle exercise session, during which fluid intakes and heart rate were recorded. Sweat samples were analysed for sodium concentration. Mean ± SD sweat sodium concentrations were 73.4 ± 27.2 mmol·L(-1) and 55.5 ± 26.8 mmol·L(-1) for the MP and NZE groups, respectively (p = 0.070). Sweat rate was 0.93 ± 0.26 L·h(-1) for the MP group and 0.89 ± 0.33 L·h(-1) for the NZE group (p = 0.357). Fluid intake was 1.05 ± 0.48 L and 0.93 ± 0.49 L for MP and NZE, respectively (p = 0.395). Half of the MP group gained weight during the exercise session compared to 37% of the NZE group. Pre-exercise urine specific gravity was significantly lower amongst the NZE group (1.016 ± 0.009 g mL(-1)) than the MP group (1.024 ± 0.008 g mL(-1)) p = 0.001. There was no significant difference in heart rate between the groups, p = 0.082. Hydration practices of athletes in NZ may differ by ethnicity, and this may highlight the need for more targeted education by ethnicity. PMID:25743610</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26170452','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26170452"><span id="translatedtitle">A Disulfide Bond-forming Machine Is Linked to the Sortase-mediated Pilus Assembly Pathway in the Gram-positive Bacterium Actinomyces <span class="hlt">oris</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Reardon-Robinson, Melissa E; Osipiuk, Jerzy; Chang, Chungyu; Wu, Chenggang; Jooya, Neda; Joachimiak, Andrzej; Das, Asis; Ton-That, Hung</p> <p>2015-08-28</p> <p>Export of cell surface pilins in Gram-positive bacteria likely occurs by the translocation of unfolded precursor polypeptides; however, how the unfolded pilins gain their native conformation is presently unknown. Here, we present physiological studies to demonstrate that the FimA pilin of Actinomyces <span class="hlt">oris</span> contains two disulfide bonds. Alanine substitution of cysteine residues forming the C-terminal disulfide bridge abrogates pilus assembly, in turn eliminating biofilm formation and polymicrobial interaction. Transposon mutagenesis of A. <span class="hlt">oris</span> yielded a mutant defective in adherence to Streptococcus oralis, and revealed the essential role of a vitamin K epoxide reductase (VKOR) gene in pilus assembly. Targeted deletion of vkor results in the same defects, which are rescued by ectopic expression of VKOR, but not a mutant containing an alanine substitution in its conserved CXXC motif. Depletion of mdbA, which encodes a membrane-bound thiol-disulfide oxidoreductase, abrogates pilus assembly and alters cell morphology. Remarkably, overexpression of MdbA or a counterpart from Corynebacterium diphtheriae, rescues the Δvkor mutant. By alkylation assays, we demonstrate that VKOR is required for MdbA reoxidation. Furthermore, crystallographic studies reveal that A. <span class="hlt">oris</span> MdbA harbors a thioredoxin-like fold with the conserved CXXC active site. Consistently, each MdbA enzyme catalyzes proper disulfide bond formation within FimA in vitro that requires the catalytic CXXC motif. Because the majority of signal peptide-containing proteins encoded by A. <span class="hlt">oris</span> possess multiple Cys residues, we propose that MdbA and VKOR constitute a major folding machine for the secretome of this organism. This oxidative protein folding pathway may be a common feature in Actinobacteria. PMID:26170452</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li class="active"><span>8</span></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_8 --> <div id="page_9" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li class="active"><span>9</span></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="161"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014ASPC..481....3S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014ASPC..481....3S"><span id="translatedtitle">The EXOTIME Monitoring Program Discovers Substellar Companion Candidates around the Rapidly Pulsating Subdwarf B Stars V1636 <span class="hlt">Ori</span> and DW Lyn</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Schuh, S.; Silvotti, R.; Lutz, R.; Kim, S.-L.; Exotime Collaboration</p> <p>2014-04-01</p> <p>The EXOTIME monitoring program has discovered sub-stellar companion candidates around the rapidly pulsating subdwarf B stars V1636 <span class="hlt">Ori</span> and DW Lyn using the timing method. Here we motivate our continuing search, and refer to descriptions of the photometric data collected, the data analysis and the characteristics of the O-C diagrams obtained. We also discuss our on-going efforts to consolidate the candidate discoveries with additional simulations and confirm them with independent methods.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/17459920','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/17459920"><span id="translatedtitle">Human cytomegalovirus UL84 interacts with an RNA stem-loop sequence found within the RNA/DNA hybrid region of <span class="hlt">ori</span>Lyt.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Colletti, Kelly S; Smallenburg, Kate E; Xu, Yiyang; Pari, Gregory S</p> <p>2007-07-01</p> <p>Human cytomegalovirus (HCMV) lytic DNA replication is initiated at the complex cis-acting <span class="hlt">ori</span>Lyt region, which spans nearly 3 kb. DNA synthesis requires six core proteins together with UL84 and IE2. Previously, two essential regions were identified within <span class="hlt">ori</span>Lyt. Essential region I (nucleotides [nt] 92209 to 92573) can be replaced with the constitutively active simian virus 40 promoter, which in turn eliminates the requirement for IE2 in the origin-dependent transient-replication assay. Essential region II (nt 92979 to 93513) contains two elements of interest: an RNA/DNA hybrid domain and an inverted repeat sequence capable of forming a stem-loop structure. Our studies now reveal for the first time that UL84 interacts with a stem-loop RNA oligonucleotide in vitro, and although UL84 interacted with other nucleic acid substrates, a specific interaction occurred only with the RNA stem-loop. Increasing concentrations of purified UL84 produced a remarkable downward-staircase pattern, which is not due to a nuclease activity but is dependent upon the presence of secondary structures, suggesting that UL84 modifies the conformation of the RNA substrate. Cross-linking experiments show that UL84 possibly changes the conformation of the RNA substrate. The addition of purified IE2 to the in vitro binding reaction did not affect binding to the stem-loop structure. Chromatin immunoprecipitation assays performed using infected cells and purified virus show that UL84 is bound to <span class="hlt">ori</span>Lyt in a region adjacent to the RNA/DNA hybrid and the stem-loop structure. These results solidify UL84 as the potential initiator of HCMV DNA replication through a unique interaction with a conserved RNA stem-loop structure within <span class="hlt">ori</span>Lyt. PMID:17459920</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20140010267','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20140010267"><span id="translatedtitle">The Chandra Delta <span class="hlt">Ori</span> Large Project: Occultation Measurements of the Shocked Gas tn the Nearest Eclipsing O-Star Binary</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Corcoran, Michael F.; Nichols, Joy; Naze, Yael; Rauw, Gregor; Pollock, Andrew; Moffat, Anthony; Richardson, Noel; Evans, Nancy; Hamaguchi, Kenji; Oskinova, Lida; Hamann, W. -R.; Gull, Ted; Ignace, Rico; Hole, Tabetha; Iping, Rosina; Walborn, Nolan; Hoffman, Jennifer; Lomax, Jamie; Waldron, Wayne; Owocki, Stan; Maiz-Apellaniz, Jesus; Leutenegger, Maurice; Hole, Tabetha; Gayley, Ken; Russell, Chris</p> <p>2013-01-01</p> <p>Delta <span class="hlt">Ori</span> is the nearest massive, single-lined eclipsing binary (O9.5 II + B0.5III). As such it serves as a fundamental calibrator of the mass-radius-luminosity relation in the upper HR diagram. It is also the only eclipsing O-type binary system which is bright enough to be observable with the CHANDRA gratings in a reasonable exposure. Studies of resolved X-ray line complexes provide tracers of wind mass loss rate and clumpiness; occultation by the X-ray dark companion of the line emitting region can provide direct spatial information on the location of the X-ray emitting gas produced by shocks embedded in the wind of the primary star. We obtained phase-resolved spectra with Chandra in order to determine the level of phase-dependent vs. secular variability in the shocked wind. Along with the Chandra observations we obtained simultaneous photometry from space with the Canadian MOST satellite to help understand the relation between X-ray and photospheric variability.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/21255899','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/21255899"><span id="translatedtitle">The N-terminus of porcine circovirus type 2 replication protein is required for nuclear localization and <span class="hlt">ori</span> binding activities</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Lin, W.-L.; Chien, M.-S.; Du, Y.-W.; Wu, P.-C.; Huang Chienjin</p> <p>2009-02-20</p> <p>Porcine circovirus type 2 possesses a circular, single-stranded DNA genome that requires the replication protein (Rep) for virus replication. To characterize the DNA binding potential and the significant region that confers the nuclear localization of the Rep protein, the defined coding regions of rep gene were cloned and expressed. All of the recombinant proteins except for the N-terminal 110 residues deletion mutant could bind to the double-stranded minimal binding site of replication origin (<span class="hlt">ori</span>). In addition, the N-terminal deletion mutant lacking 110 residues exhibited mainly cytoplasmic staining in the transfected cells in contrast to the others, which localized dominantly in the nucleus, suggesting that this N-terminal domain is essential for nuclear localization. Furthermore, a series of green fluorescence proteins (GFP) containing potential nuclear localization signal (NLS) sequences were tested for their cellular distribution. The ability of the utmost 20 residues of the N-terminal region to target the GFP to the nucleus confirmed its role as a functional NLS.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016NewA...43...87J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016NewA...43...87J"><span id="translatedtitle">The past photometric history of the FU <span class="hlt">Ori</span>-type young eruptive star 2MASS J06593158-0405277 = V960 Mon</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Jurdana-Šepić, Rajka; Munari, Ulisse</p> <p>2016-02-01</p> <p>The known FU <span class="hlt">Ori</span>-type young eruptive stars are exceedingly rare (a dozen or so confirmed objects) and 2MASS J06593158-0405277, with its 2014 outburst, is likely the latest addition to the family. All members have displayed just one such eruption in their recorded history, an event lasting for decades. To test the FU <span class="hlt">Ori</span> nature of 2MASS J06593158-0405277, we have reconstructed its photometric history by measuring its brightness on Harvard photographic plates spanning the time interval 1899-1989. No previous large amplitude eruption similar to that initiated in 2014 has been found, as in bona fide FU <span class="hlt">Ori</span>-type objects. The median value of the brightness in quiescence of 2MASS J06593158-0405277 is B = 15.5, with the time interval 1935-1950 characterized by a large variability (˜ 1 mag amplitude) that contrasts with the remarkable photometric stability displayed at later epochs. The variability during 1935-1950 can either be ascribed to some T Tau like activity of 2MASS J06593158-0405277 itself or to the also young and fainter star 2MASS J06593168-0405224 that lies 5 arcsec to the North and forms an unresolved pair at the astrometric scale of Harvard photographic plates.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4631859','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4631859"><span id="translatedtitle">Whakawhiti Kōrero, a Method for the Development of a Cultural Assessment Tool, Te Waka Kuaka, in Mā<span class="hlt">ori</span> Traumatic Brain Injury</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Elder, Hinemoa; Kersten, Paula</p> <p>2015-01-01</p> <p>The importance of tools for the measurement of outcomes and needs in traumatic brain injury is well recognised. The development of tools for these injuries in indigenous communities has been limited despite the well-documented disparity of brain injury. The wairua theory of traumatic brain injury (TBI) in Mā<span class="hlt">ori</span> proposes that a culturally defined injury occurs in tandem with the physical injury. A cultural response is therefore indicated. This research investigates a Mā<span class="hlt">ori</span> method used in the development of cultural needs assessment tool designed to further examine needs associated with the culturally determined injury and in preparation for formal validation. Whakawhiti kōrero is a method used to develop better statements in the development of the assessment tool. Four wānanga (traditional fora) were held including one with whānau (extended family) with experience of traumatic brain injury. The approach was well received. A final version, Te Waka Kuaka, is now ready for validation. Whakawhiti kōrero is an indigenous method used in the development of cultural needs assessment tool in Mā<span class="hlt">ori</span> traumatic brain injury. This method is likely to have wider applicability, such as Mental Health and Addictions Services, to ensure robust process of outcome measure and needs assessment development. PMID:26576070</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3556164','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3556164"><span id="translatedtitle">Adhesion of Streptococcus mitis and Actinomyces <span class="hlt">oris</span> in co-culture to machined and anodized titanium surfaces as affected by atmosphere and pH</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2013-01-01</p> <p>Background With the rising demand for osseointegrated titanium implants for replacing missing teeth, often in patients with a history of periodontitis, implant-related infections have become an issue of growing concern. Novel methods for treating and preventing implant-associated infections are urgently needed. The aim of this study was to investigate if different pH, atmosphere and surface properties could restrict bacterial adhesion to titanium surfaces used in dental implants. Methods Titanium discs with machined or anodized (TiUnite™) surface were incubated with a co-culture of Streptococcus mitis and Actinomyces <span class="hlt">oris</span> (early colonizers of oral surfaces) at pH 5.0, 7.0 and 9.0 at aerobic or anaerobic atmosphere. The adhesion was analysed by counting colony forming (CFU) units on agar and by confocal laser scanning microscopy (CLSM). Results The CFU analysis showed that a pH of 5.0 was found to significantly decrease the adhesion of S. mitis, and an aerobic atmosphere, the adhesion of A. <span class="hlt">oris</span>. S. mitis was found in significantly less amounts on the anodized surface than the machined surface, while A. <span class="hlt">oris</span> was found in equal amounts on both surfaces. The CLSM analysis confirmed the results from the CFU count and provided additional information on how the two oral commensal species adhered to the surfaces: mainly in dispersed clusters oriented with the groves of the machined surface and the pores of the anodized surface. Conclusions Bacterial adhesion by S. mitis and A. <span class="hlt">oris</span> can be restricted by acidic pH and aerobic atmosphere. The anodized surface reduced the adhesion of S. mitis compared to the machined surface; while A. <span class="hlt">oris</span> adhered equally well to the pores of the anodized surface and to the grooves of the machined surface. It is difficult to transfer these results directly into a clinical situation. However, it is worth further investigating these findings from an in vitro perspective, as well as clinically, to gain more knowledge of the effects acid pH and aerobic atmosphere have on initial bacterial adhesion. PMID:23298213</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/12608242','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/12608242"><span id="translatedtitle">Noma (cancrum <span class="hlt">oris</span>): case report in a 4-year-old HIV-positive South African child.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Naidoo, S; Chikte, U M</p> <p>2000-12-01</p> <p>Cancrum <span class="hlt">oris</span> (noma) is a gangrenous infection that develops in the mouth and spreads rapidly to other parts of the face. The disease occurs mostly in conditions of poverty, poor hygiene and malnutrition. In sub-Saharan Africa the frequency in several countries is estimated to be 1-7 cases per 1,000 population, and as many as 12 cases per 1,000 in the most affected communities. About 90% of these children die without receiving any care, yet the disease can, and should, be prevented. With increasing numbers of children who are malnourished and who have compromised immune systems (compounded by the HIV pandemic) the prevalence of conditions such as noma is likely to increase. Among the earliest features of noma are excessive salivation, marked fetor <span class="hlt">oris</span>, facial oedema and a greyish-black discolouration of the skin in the affected area. This devastating gangrenous lesion may involve the cheek, the chin, the infra-orbital margin, palate, nose, antrum and virtually any part of the face. This report describes a 4-year-old HIV-positive African girl, who was abandoned, discharged from the Plastics Unit and now lives in a child care sanctuary. Little is known about her history prior to her arrival at the home a few weeks previously. The clinical examination revealed a delay in growth and physical development equivalent to that of a 2-year-old child. The left cheek had a perforating ulcer in a healing phase. The perforation, about 1 cm in diameter, was surrounded by oedematous tissues showing a mild to moderate erythema. The peripheral oedema extended to the lower palpebral, the upper labial, left labial commissural, mandibular and pre-parotid regions. Submental, submandibular and cervical lymph nodes were mildly painful upon palpation. The child was not pyretic. The intra-oral examination revealed the features of acute necrotising gingivitis (ANG). ANG was generalised and showed classic interdental crater-like ulcers covered with whitish debris. Halitosis was pronounced. Examination of the second quadrant revealed a large ulcer extending from the distal aspect of the deciduous canine to the distal aspect of the second deciduous molar. The adjacent palatal mucosa was severely oedematous. The alveolar bone supporting the first and the second molars was completely exposed to the fundus of the vestibulum. It was not possible to obtain intraoral photographs or radiographs. Chlorhexidine gluconate (0.2% solution) and metronidazole tablets, 200 mg twice daily for 15 days were prescribed. The child was seen every alternate day for 10 days and her condition improved rapidly. Halitosis had subsided. She was then referred to the Johannesburg Hospital for further treatment under general anaesthesia. The proposed treatment plan was as follows: removal of dental accretions and polishing of all teeth, extraction of the left maxillary teeth supported by non-vital bone, resection of the necrotic bone in the left maxilla and reconstructive surgery in the left cheek. PMID:12608242</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24127255','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24127255"><span id="translatedtitle">Unusual labial glands in snakes of the genus Geophis Wagler, 1830 (Serpentes: Dipsadinae).</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>de Oliveira, Leonardo; da Costa Prudente, Ana Lcia; Zaher, Hussam</p> <p>2014-01-01</p> <p>Geophis belongs to the goo-eating dipsadine assemblage of snakes that are known to feed exclusively on earthworms, snails, and slugs. Although the unusual feeding strategies of the goo-eating dipsadines are well known (but poorly documented), little attention has been paid to their internal anatomy. Here, we describe a new and noteworthy morphological and histochemical condition of the infralabial glands in three species of Geophis (G. brachycephalus, G. nasalis and G. semidoliatus), all earthworm feeders. Their infralabial glands are constituted of two distinct parts: an anterolateral portion composed of mucous and seromucous cells that stretches from the tip of the dentary to the corner of the mouth, and a tubular posteromedial portion that is exclusively seromucous. The anterolateral portion receives fibers of the <span class="hlt">levator</span> <span class="hlt">anguli</span> <span class="hlt">oris</span> muscle that attaches on its posterodorsal extremity while the posteromedial portion extends posteriorly to the corner of the mouth where it receives fibers of the adductor mandibulae externus medialis muscle. Furthermore, the posteromedial portion of the infralabial gland is constituted by large acini filled with secretion that is periodic acid-Schiff positive. These acini release their secretion directly into a large lumen located in the middle of the glandular portion. In the three species examined, the supralabial glands show a traditional configuration, being constituted of mucous and seromucous cells and retaining an enlarged part in its caudal region that resembles a Duvernoy's gland. The presence in Geophis of an expanded lumen in part of the infralabial gland that is compressed by an adjacent muscle suggests a more specialized role for the secretion produced by these glands that may not be related to envenomation but rather to prey transport and mucus control. PMID:24127255</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015IAUGA..2242446C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015IAUGA..2242446C"><span id="translatedtitle">Fluorescence Processes in the Outer Atmospheres of the Evolved M-Stars Alpha <span class="hlt">Ori</span> (M2 Iab) and Gamma Cru (M3.4 III)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Carpenter, Kenneth; Kober, Gladys; Nielsen, Krister; Ayres, Thomas; Wahlgren, Glenn</p> <p>2015-08-01</p> <p>The prototypical M-giant and M-supergiant stars, Gamma Cru (M3.4 III)) and Alpha <span class="hlt">Ori</span> (M2Iab), have been observed as part of the "Advanced Spectral Library (ASTRAL) Project: Cool Stars" (PI = T. Ayres). "ASTRAL-Cool Stars" is an HST Cycle 18 Treasury Program designed to collect, using the Space Telescope Imaging Spectrograph (STIS), a definitive set of representative, high-resolution (R~46,000 in the FUV up to ~1700 , R~30,000 for 1700-2150 , and R~114,000 >2150 ) and high signal/noise (S/N>100) UV spectra of eight F-M evolved cool stars. These extremely high-quality UV echelle spectra are available from the HST archive and through the University of Colorado (http://casa.colorado.edu/~ayres/ASTRAL/). In this paper, we use the very rich emission-line spectra of the two evolved M stars in the sample, Gamma Cru (GaCrux) and Alpha <span class="hlt">Ori</span> (Betelgeuse), to study the fluorescence processes operating in their outer atmospheres. We summarize the pumping transitions and fluorescent line products known on the basis of previous work and newly identified in our on-going analysis of these extraordinary new Treasury spectra. Detailed descriptions of selected processes are given to illustrate their operation. The wide variety of fluorescence processes in operation in these outer atmospheres, both molecular and atomic, suggest that there is a mixture of warm and cool plasmas present and that H I Ly-alpha in particular is locally very strong, even though, in the case of Alpha <span class="hlt">Ori</span>, no flux is seen at earth due to strong circumstellar absorption at that wavelength. Many new fluorescence line products and several new processes have been identified in these spectra, which are more complete and of higher S/N than previously available for these stars.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25794281','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25794281"><span id="translatedtitle">A single parS sequence from the cluster of four sites closest to <span class="hlt">ori</span>C is necessary and sufficient for proper chromosome segregation in Pseudomonas aeruginosa.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Jecz, Paulina; Bartosik, Aneta A; Glabski, Krzysztof; Jagura-Burdzy, Grazyna</p> <p>2015-01-01</p> <p>Among the mechanisms that control chromosome segregation in bacteria are highly-conserved partitioning systems comprising three components: ParA protein (a deviant Walker-type ATPase), ParB protein (a DNA-binding element) and multiple cis-acting palindromic centromere-like sequences, designated parS. Ten putative parS sites have been identified in the P. aeruginosa PAO1 genome, four localized in close proximity of <span class="hlt">ori</span>C and six, diverged by more than one nucleotide from a perfect palindromic sequence, dispersed along the chromosome. Here, we constructed and analyzed P. aeruginosa mutants deprived of each single parS sequence and their different combinations. The analysis included evaluation of a set of phenotypic features, chromosome segregation, and ParB localization in the cells. It was found that ParB binds specifically to all ten parS sites, although with different affinities. The P. aeruginosa parS mutant with all ten parS sites modified (parSnull) is viable however it demonstrates the phenotype characteristic for parAnull or parBnull mutants: slightly slower growth rate, high frequency of anucleate cells, and defects in motility. The genomic position and sequence of parS determine its role in P. aeruginosa biology. It transpired that any one of the four parS sites proximal to <span class="hlt">ori</span>C (parS1 to parS4), which are bound by ParB with the highest affinity, is necessary and sufficient for the parABS role in chromosome partitioning. When all these four sites are mutated simultaneously, the strain shows the parSnull phenotype, which indicates that none of the remaining six parS sites can substitute for these four <span class="hlt">ori</span>C-proximal sites in this function. A single ectopic parS2 (inserted opposite <span class="hlt">ori</span>C in the parSnull mutant) facilitates ParB organization into regularly spaced condensed foci and reverses some of the mutant phenotypes but is not sufficient for accurate chromosome segregation. PMID:25794281</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2764697','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2764697"><span id="translatedtitle">Stable replication of the EBNA1/<span class="hlt">Ori</span>P-mediated baculovirus vector and its application to anti-HCV gene therapy</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Suzuki, Hitoshi; Matsumoto, Norihiko; Suzuki, Tomoyuki; Chang, Myint OO; Takaku, Hiroshi</p> <p>2009-01-01</p> <p>Background Hepatitis C virus (HCV) is one of the main causes of liver-related morbidity and mortality. Although combined interferon-?-ribavirin therapy is effective for about 50% of the patients with HCV, better therapies are needed and preventative vaccines have yet to be developed. Short-hairpin RNAs (shRNAs) inhibit gene expression by RNA interference. The application of transient shRNA expression is limited, however, due to the inability of the shRNA to replicate in mammalian cells and its inefficient transduction. The duration of transgene (shRNA) expression in mammalian cells can be significantly extended using baculovirus-based shRNA-expressing vectors that contain the latent viral protein Epstein-Barr nuclear antigen 1 (EBNA1) and the origin of latent viral DNA replication (<span class="hlt">Ori</span>P) sequences. These recombinant vectors contain compatible promoters and are highly effective for infecting primary hepatocyte and hepatoma cell lines, making them very useful tools for studies of hepatitis B and hepatitis C viruses. Here, we report the use of these baculovirus-based vector-derived shRNAs to inhibit core-protein expression in full-length hepatitis C virus (HCV) replicon cells. Results We constructed a long-term transgene shRNA expression vector that contains the EBV EBNA1 and <span class="hlt">Ori</span>P sequences. We also designed baculovirus vector-mediated shRNAs against the highly conserved core-protein region of HCV. HCV core protein expression was inhibited by the EBNA1/<span class="hlt">Ori</span>P baculovirus vector for at least 14 days, which was considerably longer than the 3 days of inhibition produced by the wild-type baculovirus vector. Conclusion These findings indicate that we successfully constructed a long-term transgene (shRNA) expression vector (Ac-EP-shRNA452) using the EBNA1/<span class="hlt">Ori</span>P system, which was propagated in Escherichia coli and converted into mammalian cells. The potential anti-HCV activity of the long-term transgene (shRNA) expression vector was evaluated with the view of establishing highly effective therapeutic agents that can be further developed for HCV gene therapy applications. PMID:19796392</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1997AnPh...22...43V','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1997AnPh...22...43V"><span id="translatedtitle">Thé<span class="hlt">orie</span> visco-élastique non-extensive II. Premiers tests expérimentaux de la thé<span class="hlt">orie</span> simplifiée à modes rotationnels</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Volino, F.; Gérard, H.; Miachon, S.</p> <p></p> <p>The non-extensive visco-elastic theory with rotational modes developed in (I), is tested using published data of elastic constants, refractive index, magnetic susceptibility, rotational viscosity, induced effects by strong fields, specific heat and heat of transition, and pressure effects on the transition temperature, of three typical nematic substances. A very good qualitative and quantitative agreement is obtained for all data considered. The various conjectures proposed in (I) appear to be well-verified, especially for the description of phenomena through the transition. Two important conclusions of this study are: (i) the non-trivial dependence of the experimental conditions such as the size of the sample or the applied fields, on the numerical values of the physical macroscopic quantities (ii) the evidence for the nematic materials, and thus for all liquids, of the existence of a space scale intermediate between the molecules and the sample size. This scale is the unit cell of the solid phase, as determined by single crystal crystallography. It is argued that this unified theory can advantageously replace the partial standard theories for describing the corresponding experimental reality. La thé<span class="hlt">orie</span> simplifiée à modes rotationnels développée dans l'article précédent (I), est testée à l'aide de données publiées de constantes élastiques, d'indice de réfraction, de susceptibilité magnétique, de viscosité de torsion, d'effets induits par des champs intenses, de chaleur spécifique et de chaleur de transition, et d'effets de pression sur la température de transition, de trois substances nématiques typiques. Un accord remarquable, tant du point de vue qualitatif que quantitatif, est obtenu avec toutes les données considérées. Les différentes conjectures proposées dans l'article (I) apparaissent être en très bon accord avec l'expérience, en particulier en ce qui concerne la description des phénomènes à travers la transition de phase. Deux conclusions importantes de cette étude concernent : (i) l'influence non-triviale des conditions expérimentales, telles que la taille de l'échantillon et des champs externes appliqués sur les valeurs des quantités physiques macroscopiques (ii) la mise en évidence, pour les matériaux nématogènes, et donc pour tous les liquides, de l'existence d'une échelle d'espace intermédiaire entre les molécules et l'échantillon macroscopique. Cette échelle est celle de la cellule unité du réseau cristallin de la phase solide, telle qu'on la détermine par la cristallographie de monocristaux. On argumente que la présente description peut remplacer avantageusement les descriptions partielles standards pour décrire la réalité expérimentale correspondante.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3318318','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3318318"><span id="translatedtitle">Small Plasmids Harboring qnrB19: a Model for Plasmid Evolution Mediated by Site-Specific Recombination at <span class="hlt">ori</span>T and Xer Sites</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Tran, Tung; Andres, Patricia; Petroni, Alejandro; Soler-Bistu, Alfonso; Albornoz, Ezequiel; Zorreguieta, Angeles; Reyes-Lamothe, Rodrigo; Sherratt, David J.; Corso, Alejandra</p> <p>2012-01-01</p> <p>Plasmids pPAB19-1, pPAB19-2, pPAB19-3, and pPAB19-4, isolated from Salmonella and Escherichia coli clinical strains from hospitals in Argentina, were completely sequenced. These plasmids include the qnrB19 gene and are 2,699, 3,082, 2,989, and 2,702 nucleotides long, respectively, and they share extensive homology among themselves and with other previously described small qnrB19-harboring plasmids. The genetic environment of qnrB19 in all four plasmids is identical to that in these other plasmids and in transposons such as Tn2012, Tn5387, and Tn5387-like. Nucleotide sequence comparisons among these and previously described plasmids showed a variable region characterized by being flanked by an <span class="hlt">ori</span>T locus and a Xer recombination site. We propose that this arrangement could play a role in the evolution of plasmids and present a model for DNA swapping between plasmid molecules mediated by site-specific recombination events at <span class="hlt">ori</span>T and a Xer target site. PMID:22290975</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/20858603','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/20858603"><span id="translatedtitle">A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Mā<span class="hlt">ori</span>, case and control sample sets.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Phipps-Green, Amanda J; Hollis-Moffatt, Jade E; Dalbeth, Nicola; Merriman, Marilyn E; Topless, Ruth; Gow, Peter J; Harrison, Andrew A; Highton, John; Jones, Peter B B; Stamp, Lisa K; Merriman, Tony R</p> <p>2010-12-15</p> <p>Genetic variation in ABCG2 (rs2231142, Q141K), encoding a uric acid transporter, is associated with gout in diverse populations. The aim of this study was to examine a role for ABCG2 in gout susceptibility in New Zealand Mā<span class="hlt">ori</span>, Pacific Island and Caucasian samples. Patients (n = 185, 173 and 214, for Mā<span class="hlt">ori</span>, Pacific Island and Caucasian, respectively) satisfied the American College of Rheumatology gout classification criteria. The comparison samples comprised 284, 129 and 562 individuals, respectively, without gout. rs2231142 was genotyped and stratification accounted for using genomic control markers. Association of the minor allele of rs2231142 with gout was observed in the Pacific Island samples (OR = 2.80, P(STRAT) < 0.001 after accounting for effects of population structure), but not in the Mā<span class="hlt">ori</span> samples (OR = 1.08, P(STRAT)= 0.70), with heterogeneity in association evident between the Mā<span class="hlt">ori</span> and Pacific Island datasets (P(HET) = 0.001). A similar dichotomy in association was observed when samples were stratified into Western (Tonga, Samoa, Niue, Tokelau) versus Eastern Polynesian (Mā<span class="hlt">ori</span>, Cook Island) origin (OR = 2.59, P(STRAT) < 0.001; OR = 1.12, P(STRAT)= 0.48, respectively; P(HET) = 0.005). Association with gout was observed in the Caucasian samples (OR = 2.20, P = 3.2 × 10(-8)). Unlike SLC2A9, which is a strong risk factor for gout in both Mā<span class="hlt">ori</span> and Pacific Island people, ABCG2 rs2231142 has a strong effect only in people of Western Polynesian ancestry. Our results emphasize the need to account for sub-population differences when undertaking biomedical genetic research in a group defined by a geographical region and shared ancestry but characterized by migratory events that create bottlenecks and altered genetic structure in the founder populations. PMID:20858603</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2750763','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2750763"><span id="translatedtitle">On the origin, homologies and evolution of primate facial muscles, with a particular focus on hominoids and a suggested unifying nomenclature for the facial muscles of the Mammalia</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Diogo, R; Wood, B A; Aziz, M A; Burrows, A</p> <p>2009-01-01</p> <p>The mammalian facial muscles are a subgroup of hyoid muscles (i.e. muscles innervated by cranial nerve VII). They are usually attached to freely movable skin and are responsible for facial expressions. In this study we provide an account of the origin, homologies and evolution of the primate facial muscles, based on dissections of various primate and non-primate taxa and a review of the literature. We provide data not previously reported, including photographs showing in detail the facial muscles of primates such as gibbons and orangutans. We show that the facial muscles usually present in strepsirhines are basically the same muscles that are present in non-primate mammals such as tree-shrews. The exceptions are that strepsirhines often have a muscle that is usually not differentiated in tree-shrews, the depressor supercilii, and lack two muscles that are usually differentiated in these mammals, the zygomatico-orbicularis and sphincter colli superficialis. Monkeys such as macaques usually lack two muscles that are often present in strepsirhines, the sphincter colli profundus and mandibulo-auricularis, but have some muscles that are usually absent as distinct structures in non-anthropoid primates, e.g. the <span class="hlt">levator</span> labii superioris alaeque nasi, <span class="hlt">levator</span> labii superioris, nasalis, depressor septi nasi, depressor <span class="hlt">anguli</span> <span class="hlt">oris</span> and depressor labii inferioris. In turn, macaques typically lack a risorius, auricularis anterior and temporoparietalis, which are found in hominoids such as humans, but have muscles that are usually not differentiated in members of some hominoid taxa, e.g. the platysma cervicale (usually not differentiated in orangutans, panins and humans) and auricularis posterior (usually not differentiated in orangutans). Based on our observations, comparisons and review of the literature, we propose a unifying, coherent nomenclature for the facial muscles of the Mammalia as a whole and provide a list of more than 300 synonyms that have been used in the literature to designate the facial muscles of primates and other mammals. A main advantage of this nomenclature is that it combines, and thus creates a bridge between, those names used by human anatomists and the names often employed in the literature dealing with non-human primates and non-primate mammals. PMID:19531159</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/20090042841','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/20090042841"><span id="translatedtitle">Suzaku Observation of Strong Fluorescent Iron Line Emission from the Young Stellar Object V1647 <span class="hlt">Ori</span> during Its New X-ray Outburst</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Hamaguchi, Kenji; Grosso, Nicolas; Kastner, Joel H.; Weintraub, David A.; Richmond, Michael</p> <p>2009-01-01</p> <p>The Suzaku X-ray satellite observed the young stellar object V1647 <span class="hlt">Ori</span> on 2008 October 8 during the new mass accretion outburst reported in August 2008. During the 87 ksec observation with a net exposure of 40 ks, V1647 <span class="hlt">Ori</span> showed a. high level of X-ray emission with a gradual decrease in flux by a factor of 5 and then displayed an abrupt flux increase by an order of magnitude. Such enhanced X-ray variability was also seen in XMM-Newton observations in 2004 and 2005 during the 2003-2005 outburst, but has rarely been observed for other young stellar objects. The spectrum clearly displays emission from Helium-like iron, which is a signature of hot plasma (kT approx.5 keV). It also shows a fluorescent iron Ka line with a remarkably large equivalent width of approx. 600 eV. Such a, large equivalent width indicates that a part of the incident X-ray emission that irradiates the circumstellar material and/or the stellar surface is hidden from our line of sight. XMM-Newton spectra during the 2003-2005 outburst did not show a strong fluorescent iron Ka line ; so that the structure of the circumstellar gas very close to the stellar core that absorbs and re-emits X-ray emission from the central object may have changed in between 2005 and 2008. This phenomenon may be related to changes in the infrared morphology of McNeil's nebula between 2004 and 2008.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/15457010','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/15457010"><span id="translatedtitle">New technique for correction of the microform cleft lip using vertical interdigitation of the orbicularis <span class="hlt">oris</span> muscle through the intraoral incision.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cho, Byung Chae</p> <p>2004-10-01</p> <p>A microform cleft lip has three major components: (1) a minor defect of the upper vermilion border with loss of the mucocutaneous ridge; (2) a narrow ridge of tissue, resembling an exaggerated philtral column extending to the nostril sill; and (3) a deformity of the nostril. To attain the muscle continuity without an external scar on the upper lip, the author introduced a new method for the correction of a microform cleft lip deformity using vertical interdigitation of the orbicularis <span class="hlt">oris</span> muscle through the intraoral incision to create the philtrum. Through the intraoral incision, a full-thickness incision is made down to the mucosa and the posterior portion of the muscle. Then, the remaining portion of the muscle is dissected. The medial and lateral muscle flaps are also detached from the oral mucosa and completely exposed and split into two leaves. The upper leaf of the lateral muscle flap is sutured to the dermis on the philtral dimple and base of the upper leaf of the medial muscle flap. Two leaves of each muscle flap are sutured together to create a vertical interdigitation to increase the thickness of the philtral column and to provide continuity of the muscle. A total of 12 patients with microform cleft lip were treated between August of 2001 and October of 2002. Seven of the patients were male and five were female, with an age range of 1 to 43 years. The follow-up period ranged from 6 months to 15 months, with an average follow-up of 9 months. The results of vertical interdigitation of the muscle were examined. All patients were satisfied with their results. The orbicularis <span class="hlt">oris</span> muscle provided continuity and preserved good function. In all cases, the operation scar was not visible on the depressed philtral groove on the cleft side. Correction of cleft lip nasal deformity was performed in four patients and alar base advancement was performed in two patients. The advantages of the proposed procedure include the creation of an anatomically natural philtrum without an external visible scar through the intraoral incision, preservation of the continuity and function of the muscle, and sufficient augmentation of the philtral column by the vertical interdigitation of the muscle. PMID:15457010</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=212377','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=212377"><span id="translatedtitle">Revised genetic map of the distal end of the F transfer operon: implications for DNA helicase I, nicking at <span class="hlt">ori</span>T, and conjugal DNA transport.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Traxler, B A; Minkley, E G</p> <p>1987-01-01</p> <p>The DNA transfer stage of conjugation requires the products of the F sex factor genes traMYDIZ and the cis-acting site <span class="hlt">ori</span>T. Previous interpretation of genetic and protein analyses suggested that traD, traI, and traZ mapped as contiguous genes at the distal end of the transfer operon and saturated this portion of the F transfer region (which ends with an IS3 element). Using antibodies prepared against the purified TraD and TraI proteins, we analyzed the products encoded by a collection of chimeric plasmids constructed with various segments of traDIZ DNA. We found the traI gene to be located 1 kilobase to the right of the position suggested on previous maps. This creates an unsaturated space between traD and traI where unidentified tra genes may be located and leaves insufficient space between traI and IS3 for coding the 94-kilodalton protein previously thought to be the product of traZ. We found that the 94-kilodalton protein arose from a translational restart and corresponds to the carboxy terminus of traI; we named it TraI*. The precise physical location of the traZ gene and the identity of its product are unknown. The <span class="hlt">ori</span>T nicking activity known as TraZ may stem from unassigned regions between traD and traI and between traI and IS3, but a more interesting possibility is that it is actually a function of traI. On our revised map, the position of a previously detected RNA polymerase-binding site corresponds to a site at the amino terminus of traI rather than a location 1 kilobase into the coding region of the gene. Furthermore, the physical and genetic comparison of the F traD and traI genes with those of the closely related F-like conjugative plasmids R1 and R100 is greatly simplified. The translational organization we found for traI, together with its identity as the structural gene for DNA helicase I, suggests a possible functional link to several other genes from which translational restart polypeptides are expressed. These include the primases of the conjugative plasmids ColI and R16, the primase-helicase of bacteriophage T7, and the cisA product (nickase) of phage phi X174. Images PMID:3036780</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1997AnPh...22..181V','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1997AnPh...22..181V"><span id="translatedtitle">Thé<span class="hlt">orie</span> visco-élastique non-extensive VI. Application à un liquide formant une phase vitreuse: l'OrthoTerPhényl (OTP)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Volino, F.; Gérard, H.; Gebel, G.</p> <p></p> <p>The non-extensive visco-elastic theory developed in articles (I-V) is tested using experimental data of a glass forming liquid, orthoterphenyl (OTP). This system has been widely studied during the last fifty years. One obtains a coherent and rather simple description of a large number of these data, of statical, dynamical, thermodynamical and spectroscopical nature, if one supposes that the viscous phase between the melting temperature of the crystal and the glass transition temperature is a (quasi) simultaneous translational and rotational transition predicted by the theory, spread over this temperature range. The rather comprehensive analysis presented on this particular system, suggests that the theory is adequate to describe, in a unified manner, the main physical properties of liquids in their stable state between the boiling temperature and the melting temperature of the crystal, and, when they can be supercooled, in their metastables states until very low temperatures. In this latter situation, the description provides, among other things, a simple interpretation of the experimental features associated with the so-called "α relaxation", "β relaxation" and "boson peak". It is suggested that spreading of the transition is to be associated with onset of spatial density fluctuations, transforming the medium from homogeneous to inhomogeneous. The maximum local density increases faster than the average density as temperature decreases, and seems to level off at the conventional glass transition temperature. La thé<span class="hlt">orie</span> visco-élastique non-extensive développée dans (I-V) est testée à l'aide d'un grand nombre de données expérimentales concernant un liquide formant une phase vitreuse. Le système choisi est l'orthoterphényl (OTP), qui a été très étudié depuis un demi-siècle, et a beaucoup servi à tester diverses thé<span class="hlt">ories</span> et modèles. En utilisant systématiquement les idées développées dans les articles précédents (I-V), on obtient une description cohérente assez simple d'un grand nombre de ces données expérimentales de nature statique, dynamique, thermodynamique et spectroscopique, si l'on suppose que la phase visqueuse, entre le point de fusion du cristal et la température de transition vitreuse est une transition de la thé<span class="hlt">orie</span>, à la fois translationnelle et rotationnelle, très "étalée" sur cet intervalle de température. Cette analyse assez complète de ce système particulier, suggère que la thé<span class="hlt">orie</span> devrait permettre de décrire, de façon unifiée, les propriétés physiques des liquides dans leur état stable entre la température d'ébullition et celle de fusion du cristal, et, quand ils peuvent être sur-refroidis, dans leurs états métastables jusqu'aux très basses températures. Dans ce dernier cas, la description fournit, entre autres choses, une interprétation simple des caractéristiques expérimentales connues sous les vocables de "relaxation α", "relaxation β" et "pic de bosons". On suggère que l'étalement de la transition est associée avec l'apparition de fluctuations spatiales de la densité, qui rendent le milieu inhomogène. La densité locale maximum augmente plus vite que la densité moyenne quand la température diminue, et semble saturer à la température de transition vitreuse.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li class="active"><span>9</span></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_9 --> <div id="page_10" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li class="active"><span>10</span></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="181"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3613878','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3613878"><span id="translatedtitle">Single horizontal Y-V vermilion plasty including orbicularis <span class="hlt">oris</span> muscle repair for secondary correction of the whistling defect: A universal technique</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Vairaktaris, Elefterios; Stelzle, Florian; Scheller, Konstanze</p> <p>2013-01-01</p> <p>Objectives: The present prospective study aimed at objectively evaluating the relevance of a single horizontal Y-V vermilion plasty including orbicularis <span class="hlt">oris</span> muscle repair for secondary correction of whistling deformities in unilateral as well as bilateral cleft lip cases. Study Design: Ten patients were included in the study (mean age 20.26.2 years). The size of the whistling defects was determined on photographs before and 12 months after surgery. Additional surgical procedures like columella lengthening and rhinoplasty were documented. Results: Seven minor and 3 moderate whistling defects were corrected. In 7 patients additional procedures were carried out. The data of the 12 months follow-up showed that the whistling defect was significantly reduced in size (p<0005). In 7 out of 10 patients the result of surgery was rated good and in 3 patients moderate. Conclusions: The present prospective study is the first one to show on an objective basis that the presented technique allows reducing whistling deformities significantly with good overall results in the majority of the cases. Moreover, the technique can be combined with other corrective procedures like columella lengthening without problems. As a consequence, it is a relevant and universal surgical technique for the correction of whistling defects. Key words:Bilateral cleft lip, unilateral cleft lip, secondary correction, vermillion plasty, whistling defect. PMID:23229265</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3882284','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3882284"><span id="translatedtitle">An innovative team-based stop smoking competition among M?<span class="hlt">ori</span> and Pacific Island smokers: rationale and method for the study and its evaluation</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2013-01-01</p> <p>Background M?<span class="hlt">ori</span> and Pacific Island people have significantly higher smoking rates compared to the rest of the New Zealand population. The main aim of this paper is to describe how knowledge of Indigenous peoples practices and principles can be combined with proven effective smoking cessation support into a cessation intervention appropriate for Indigenous people. Methods/Design A literature review was conducted to identify what cultural principles and practices could be used to increase salience, and what competition elements could have an impact on efficacy of smoking cessation. The identified elements were incorporated into the design of a cessation intervention. Discussion Cultural practices incorporated into the intervention include having a holistic family or group-centred focus, inter-group competitiveness, fundraising and ritual pledging. Competition elements included are social support, pharmacotherapy use, cash prize incentives and the use of a dedicated website and iPad application. A pre-test post-test will be combined with process evaluation to evaluate if the competition results in triggering mass-quitting, utilisation of pharmacotherapy and in increasing sustained smoking cessation and to get a comprehensive understanding of the way in which they contribute to the effect. The present study is the first to describe how knowledge about cultural practices and principles can be combined with proven cessation support into a smoking cessation contest. The findings from this study are promising and further more rigorous testing is warranted. PMID:24365329</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/8083993','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/8083993"><span id="translatedtitle">The human cytomegalovirus origin of DNA replication (<span class="hlt">ori</span>Lyt) is the critical cis-acting sequence regulating replication-dependent late induction of the viral 1.2-kilobase RNA promoter.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wade, E J; Spector, D H</p> <p>1994-10-01</p> <p>Plasmid constructs containing the 1.2-kb RNA promoter from the long terminal repeat region of human cytomegalovirus (HCMV) display the early-phase regulation of this promoter but lack the characteristic late induction (E. J. Wade, K. M. Klucher, and D. H. Spector, J. Virol. 66:2407-2417, 1992). To determine if the HCMV origin of replication (<span class="hlt">ori</span>Lyt) was necessary and sufficient for the late induction of the 1.2-kb RNA promoter, we cloned a 9.6-kbp segment of the origin of replication onto the p456 OCAT plasmid containing the 1.2-kb RNA promoter. This plasmid was designated <span class="hlt">ori</span>456 OCAT. A control construct, which contains all of the same sequences as the <span class="hlt">ori</span>456 OCAT construct except that a 2.4-kbp segment derived from HCMV EcoRI segment U is inverted in orientation to disrupt the origin function, was designated inv456 OCAT. After electroporation into human fibroblast cells and infection with HCMV 24 h later, <span class="hlt">ori</span>456 OCAT replicated and showed the same early and late transcription pattern as the authentic viral 1.2-kb RNA. Under similar conditions, the inv456 OCAT neither replicated nor showed late induction. Experiments using plasmids synthesized in bacteria lacking methylation activity demonstrated that the late induction was not dependent on the change in methylation state of the plasmids. Ganciclovir, an inhibitor of the HCMV DNA polymerase, was used to demonstrate the replication dependence of the expression of the virally encoded 1.2-kb RNA, while the nearby early 2.7-kb RNA was unaffected. Ganciclovir also inhibited the late induction of the chloramphenicol acetyltransferase gene from <span class="hlt">ori</span>456 OCAT, while expression from inv456 OCAT increased. Site-specific mutations in two previously identified important regulatory elements of the 1.2-kb RNA promoter, the AP1-binding site and the CATA site, indicated that these sites continue to contribute to promoter activity at late times but that the replication-dependent late induction acts independently of these sites. Possible mechanisms underlying the late induction are discussed. PMID:8083993</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016MNRAS.457.3372M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016MNRAS.457.3372M"><span id="translatedtitle">Physical parameters and long-term photometric variability of V1481 <span class="hlt">Ori</span>, an SB2 member of Orion nebula Cluster with an accreting component</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Messina, S.; Parihar, P.; Biazzo, K.; Lanza, A. F.; Distefano, E.; Melo, C. H. F.; Bradstreet, D. H.; Herbst, W.</p> <p>2016-04-01</p> <p>We present the results of our analysis on V1481 <span class="hlt">Ori</span> (JW 239), a young SB2 in the Orion nebula Cluster with a circumbinary disc accreting on the lower mass component. The analysis is based on high-resolution spectroscopic data and high-quality photometric time series about 20-yr long. Thanks to the spectroscopy, we confirm the binary nature of this system consisting of M3 + M4 components and derive the mass ratio MB/MA = 0.54, a variable luminosity ratio LB/LA = 0.68-0.94, and an orbital period Porb = 4.433 d. The photometric data allowed us to measure the rotation periods of the two components Pphot = 4.4351 d and they are found to be synchronized with the orbital period. The simultaneous modelling of V-, I-band, and radial velocity curves in the 2005 season suggests that the variability is dominated by one hotspot on the secondary component covering at least ˜3.5 per cent of the stellar surface and about 420 K hotter than the unperturbed photosphere. Such a spot may originate from the material of the circumbinary disc accreting on to the secondary component. We also detect an apparent 6-yr periodic variation in the position of this hotspot, which is inferred from the phase migration of the light-curve maximum, which we interpret as due to either the presence of surface differential rotation as large as 0.065 per cent, a value compatible with the fully convective components, or to a periodic exchange of angular momentum between the disc and the star, which implies a minimum magnetic field strength of 650 G at the stellar surface.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4784150','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4784150"><span id="translatedtitle">Eye-rima <span class="hlt">oris</span> distance and its relation to the vertical dimension of occlusion measured by two methods: Anthropometric study in a sample of Yemeni dental students</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Alhajj, Mohammed Nasser; Khalifa, Nadia; Amran, Abdullah</p> <p>2016-01-01</p> <p>Objective: This study was conducted to evaluate the relationship between the distance measured from the distal outer of the eye to the parting line of the lips and the occlusal vertical dimension (OVD) measured by two methods. Methods: One hundred and fourteen dental students (76 males and 38 females) were recruited for this study with mean age (22.34 ± 1.83) years. The distance from distal canthus of the eye to rima <span class="hlt">oris</span> (eye-RO) was compared with two different measurements of the OVD (nasal [N] to gnathion [Gn], and subnasal [Sn] to menton [Me]). All distances were measured using modified digital caliper. Results: Pearson correlation coefficient test for correlations and paired samples t-test for differences were used with a significant level of (P < 0.05). There was a positive significant correlation between the eye-RO distance and the two measurements of the OVD. However, this correlation was stronger between eye-RO and the distance from the tip of the nose to the tip of the chin than that between eye-RO and the distance from the septum of the nose to the under of the chin (r = 0.313 with P = 0.0007, r = 0.296 with P = 0.0014), respectively. Conclusion: The distance from the outer canthus of the eye to the parting of the lips seems to be a reliable method in predicting the OVD and should relate to the distance from the tip of the nose to the tip of the chin. PMID:27011736</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016IJEaS.tmp...17Z','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016IJEaS.tmp...17Z"><span id="translatedtitle">U-Pb zircon and biostratigraphic data of high-pressure/low-temperature metamorphic rocks of the Talea <span class="hlt">Ori</span>: tracking the Paleotethys suture in central Crete, Greece</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zulauf, G.; Dörr, W.; Krahl, J.; Lahaye, Y.; Chatzaras, V.; Xypolias, P.</p> <p>2016-03-01</p> <p>Inherited deformation microfabrics of detrital quartz grains and U-Pb (Laser ablation (LA)-ICPMS and ID TIMS) ages of detrital zircons separated from the Phyllite-Quartzite Unit s.l. of the Talea <span class="hlt">Ori</span>, central Crete, suggest strikingly different source rocks. Albite gneiss of the lower Rogdia Beds includes Cambrian and Neoproterozoic rounded zircons with main U-Pb age peaks at 628 and 988 Ma. These and minor Paleoproterozoic and Archean peaks, together with the lack of Variscan-aged and Mesoproterozoic zircons, are similar to the age spectra obtained from the Phyllite-Quartzite Unit s.str. of the Peloponnesus and eastern Crete and from the Taurides. All of these zircons should be derived from the northeastern passive margin of Gondwana (Cimmeria). Metatuffites of the uppermost Rogdia Beds and metasandstone of Bali beach, on the other hand, include euhedral detrital zircons displaying a Variscan U-Pb age spectra at ca. 300 Ma with concordia ages at 291 ± 3, 300 ± 1 Ma (Rogdia) and 286 ± 3, 300 ± 3, 313 ± 2 Ma (Bali). Both types of metasediments and their zircons are similar to those of the pre-Alpine basement and overlying Tyros Beds of eastern Crete, revealing a provenance at the southern active margin of Laurasia. Thus, in central Crete the Paleotethys suture should be situated inside the Rogdia Beds. Magmatic zircons separated from a rhyolite boulder of the lower Achlada Beds yielded a concordant U-Pb zircon age at 242 ± 2 Ma placing a maximum age for the deposition of the (meta)conglomerate from which the boulder was collected. This age is compatible with an Olenekian-early Anisian age of the underlying Vasilikon marble suggested by new findings of the foraminifera Meandrospira aff. pusilla. Both the Achlada Beds and the Vasilikon marble can be attributed to the lower Tyros Beds of eastern Crete. The Alpine deformation led to a pervasive mylonitic foliation, which is affecting most of the studied rocks. This foliation results from D2 top-to-the-north shearing, which post-dates the growth of blue amphiboles (crossite).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015AAS...22534408C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015AAS...22534408C"><span id="translatedtitle">Mining the HST "Advanced Spectral Library (ASTRAL)": Winds of the Evolved M Stars Alpha <span class="hlt">Ori</span> (M2 Iab) and Gamma Cru (M3.4 III)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Carpenter, Kenneth G.; Nielsen, Krister E.; Kober, Gladys V.; Ayres, Thomas R.</p> <p>2015-01-01</p> <p>The "Advanced Spectral Library (ASTRAL) Project: Cool Stars" (PI = T. Ayres) is an HST Cycle 18 Treasury Program that collected a definitive set of representative, high-resolution (R=30,000-100,000) and high signal/noise (S/N>100) UV spectra of eight F-M evolved cool stars. These extremely high-quality STIS UV echelle spectra are available from the HST archive and through the ASTRAL website at the University of Colorado at http://casa.colorado.edu/~ayres/ASTRAL/ and will enable investigations of a broad range of problems -- stellar, interstellar, and beyond -- for many years. In this paper, we examine the wealth of wind diagnostics contained in the very rich spectra of the two evolved M stars in the sample, the M3.4 III giant Gamma Crucis (GaCrux) and the M2 Iab supergiant Alpha Orionis (Betelgeuse) and characterize the winds at the time of these STIS observations in 2011 and compare the results with those obtained from more limited data taken at earlier epochs with HST/GHRS and IUE. In particular we study the variation of the numerous Fe II profiles with intrinsic strength in the two stars. The shifting wavelengths of the wind absorptions relative to the emission peaks and the changes in relative strengths of the emission peaks reflect the acceleration of the wind from the base of the chromosphere. Although the characteristics of the Gamma Cru wind are relatively stable with time, the Alpha <span class="hlt">Ori</span> wind outflow appears significantly smaller than seen by Carpenter et al. (1997, ApJ, 479, 970) in GHRS observations taken in 1992 (and in earlier IUE observations). There might in fact be evidence in these STIS spectra that the outflow has turned into an inflow, as reported at epochs prior to IUE by Boesgaard and Magnan (1975 ApJ 198, 369) and Boesgaard (1979 ApJ 232, 485) based on a limited number of lines in the extreme blue end of ground-based spectra.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21402398','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21402398"><span id="translatedtitle">Organochlorines and heavy metals in wild caught food as a potential human health risk to the indigenous M?<span class="hlt">ori</span> population of South Canterbury, New Zealand.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stewart, Michael; Phillips, Ngaire R; Olsen, Greg; Hickey, Christopher W; Tipa, Gail</p> <p>2011-05-01</p> <p>Increasing concentrations of anthropogenic contaminants in wild kai (food) of cultural, recreational and economic importance to the indigenous M?<span class="hlt">ori</span> of New Zealand is a potential human health risk. Contaminants that are known to bioaccumulate through the food chain (e.g., organochlorine pesticides (OCPs), PCBs and selected heavy metals) were analysed in important kai species including eel (Anguilla sp.), brown trout (Salmo trutta), black flounder (Rhombosolea retiaria) and watercress (Nasturtium officinale) from important harvesting sites in the region of South Canterbury. Eels contained relatively high wet weight concentrations of p,p'-DDE (8.6-287ng/g), PCBs ((32)?(PCB); 0.53-58.3ng/g), dieldrin (<0.05-16.3ng/g) and ?chlordanes (0.03-10.6ng/g). Trout and flounder contained lower concentrations of organochlorines than eels, with p,p'-DDE wet weight concentrations ranging from 2.2 to 18.5ng/g for trout and 6.4 to 27.8ng/g for flounder. Total arsenic wet weight concentrations were below detection limits for eels but ranged from 0.27 to 0.89?g/g for trout and 0.12 to 0.56?g/g for flounder. Mercury concentrations ranged from 0.02 to 0.56?g/g, 0.11 to 0.50?g/g and 0.04 to 0.10?g/g (ww) for eel, trout and flounder respectively. Lifetime excess cancer risk was calculated through established risk assessment procedures, highlighting dieldrin, ?PCBs and p,p'-DDE in eels and arsenic in trout and flounder as primary contaminants of concern. A second non-cancer chronic health risk assessment indicated that mercury and PCBs were a potential concern in eels and mercury in trout. A cumulative lifetime cancer risk assessment showed potential health risk for consumption of some species, even at low consumption rates and provided the basis for establishing recommended dietary consumption limits for harvest sites within the study region. PMID:21402398</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/9858684','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/9858684"><span id="translatedtitle">Targeting and retrofitting pre-existing libraries of transposon insertions with FRT and <span class="hlt">ori</span>V elements for in-vivo generation of large quantities of any genomic fragment.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wild, J; Sektas, M; Hradecn, Z; Szybalski, W</p> <p>1998-11-26</p> <p>A procedure is described that converts the pre-existing transposon insertion libraries to a collection of 'pop-out' strains, each allowing generation of 20- to 100-kb genomic fragments directly from the genome. The procedure consists of two steps: (1) single transposon insertions are targeted and retrofitted with excision and amplification elements (FRT and <span class="hlt">ori</span>V), by homologous recombination with an FRT-<span class="hlt">ori</span>V-carrying plasmid; and (2) two retrofitted neighbouring transposons are brought together by P1 transduction. From each strain, a 20- to 100-kb genomic fragment, bound by a pair of retrofitted transposons, could be excised and amplified upon supplying in trans the excision (Flp) and replication (TrfA) functions. To enhance the efficiency of crossing-in the FRT-<span class="hlt">ori</span>V cassette, we transiently increased the copy number of our retrofitting plasmids using a temperature-sensitive TrfA-supplying helper plasmid. Using FRT-<span class="hlt">ori</span>V and helper plasmids, we retrofitted four Tn10KmR and three Tn10CmR insertions. Subsequently, the FRT-<span class="hlt">ori</span>V retrofitted insertions were crossed with each other in pairs (KmRxCmR), using P1 phage transductions. The resulting CmRFRT-[28-65-kb]-KmRFRT strains were transformed with a plasmid expressing FLP and trfA genes from the tightly controlled Ptet promoter. Induction of this tightly repressed promoter by autoclaved chlortetracycline (cTc) resulted in the efficient excision and amplification of genomic fragments located between FRT sites, but only in productive strains, i.e. having two parallel FRTs. We have shown that genomic fragments of 28-, 40-, 50- and 65-kb were efficiently excised and amplified. Furthermore, we could convert non-productive strains (having FRTs in non-parallel orientation), to productive combination of parallel FRTs, because one of the FRT elements was flanked by two convergent loxP sites, and thus could be inverted by the Cre function delivered either by the P1 phage or by a specially constructed temperature-sensitive Plac-cre plasmid. Although several microbial genomes were recently sequenced, the described method will help in supplying large quantities of any genomic fragment (prepared without the conventional cloning and its artifacts) for refined sequence comparison among strains and species, and for further analysis of uncharacterized ORFs, various mutations, and regulatory elements or functions. The excised and circularized DNA fragments (plasmids) could be propagated like any other large plasmids but only in hosts that could supply the appropriate Rep function. Our original 'pop-out' method [Psfai et al. (1994) Nucleic Acids Res. 22, 2392-2398] was already employed for sequencing of the E. coli genome [Blattner et al. (1997) Science 277, 1453-1462]. Moreover, the Flp-mediated recombination between two FRT elements resulted in bacterial strains with large deletions (for parallel FRT orientations) or with large inversions (for inverted FRT orientations). PMID:9858684</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=506931','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=506931"><span id="translatedtitle">Human Cytomegalovirus UL84 Oligomerization and Heterodimerization Domains Act as Transdominant Inhibitors of <span class="hlt">ori</span>Lyt-Dependent DNA Replication: Evidence that IE2-UL84 and UL84-UL84 Interactions Are Required for Lytic DNA Replication</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Colletti, Kelly S.; Xu, Yiyang; Cei, Sylvia A.; Tarrant, Margaret; Pari, Gregory S.</p> <p>2004-01-01</p> <p>Human cytomegalovirus (HCMV) UL84 encodes a 75-kDa protein required for <span class="hlt">ori</span>Lyt-dependent DNA replication and interacts with IE2 in infected and transfected cells. UL84 localizes to the nucleus of transfected and infected cells and is found in viral replication compartments. In transient assays it was shown that UL84 can interfere with the IE2-mediated transactivation of the UL112/113 promoter of HCMV. To determine whether UL84 protein-protein interactions are necessary for lytic DNA synthesis, we purified UL84 and used this protein to generate a monoclonal antibody. Using this antibody, we now show that UL84 forms a stable interaction with itself in vivo. The point of self-interaction maps to a region of the protein between amino acids 151 and 200, a domain that contains a series of highly charged amino acid residues. Coimmunoprecipitation assays determined that UL84 interacts with a protein domain present within the first 215 amino acids of IE2. We also show that an intact leucine zipper domain of UL84 is required for a stable interaction with IE2 and UL84 leucine zipper mutants fail to complement <span class="hlt">ori</span>Lyt-dependent DNA replication. UL84 leucine zipper mutants no longer interfere with IE2-mediated transactivation of the UL112/113 promoter, confirming that the leucine zipper is essential for a functional interaction with IE2. In addition, we demonstrate that both the leucine zipper and oligomerization domains of UL84 can act as transdominant-negative inhibitors of lytic replication in the transient assay, strongly suggesting that both an IE2-UL84 and a UL84-UL84 interaction are required for DNA synthesis. PMID:15308715</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015EGUGA..17.9340T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015EGUGA..17.9340T"><span id="translatedtitle">Shear zones at the base of the lowermost known unit of the Cretan nappe pile in the Talea <span class="hlt">Ori</span>, northern central Crete - the long-time deformation record during burial and exhumation from HP-LT metamorphic conditions</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Trepmann, Claudia</p> <p>2015-04-01</p> <p>The structural characteristics and microfabrics of shear zones at the base of the lowermost known level of the Cretan nappe pile, exposed at the northern central coast of the Talea <span class="hlt">Ori</span> Mountains, are presented. There, the high pressure - low temperature (HP-LT) metamorphic sediments provide information on the long-term geological history from the pre-Alpine basement and the Alpine stages of detachment, burial to and exhumation from HP-LT conditions. Information on the unknown pre-Alpine basement of the metasedimentary unit is obtained by the components in low-strain metaconglomerates, where deformation microstructures from the source rocks are preserved or quasi-statically overprinted during the later geological history. Information on the deformation mechanisms and stress history during detachment, burial and exhumation is obtained by high-strain shear zones surrounding the low-strain metasediments. A gradual transition from the low-strain metaconglomerates and associated black shales and metacherts to shear zones characterized by a scaly foliation, shear bands and associated quartz veins is observed. Shear bands occur likewise in black shales, metaquartzites and metaconglomerates and are inclined at various angles to the sedimentary layering or the scaly foliation, respectively. They generally indicate down-faulting of the respective northern block. Associated quartz veins taper wedge-shaped at a high angle to the foliation, decorating the shear band boundaries and showing shear offsets. Microstructures in rocks from these shear bands and related vein quartz show indication of dislocation glide-controlled deformation of quartz by the presence of deformation lamellae, deformation bands, short-wavelength undulatory extinction and localized strings of recrystallized grains. The shear zones document at least two different deformation stages: A first stage of deformation is characterized mainly by dissolution precipitation creep generating the scaly cleavage and implying low-stress viscous flow. A second stage is recorded by the shear bands and associated quartz veins, indicating episodic deformation at transient high stresses. Strain during the second deformation stage is apparently localized in pre-existing shear zones, i.e. representing shear zone reactivation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/7263030','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/7263030"><span id="translatedtitle">Motor fuel additive and <span class="hlt">ori</span>-inhibited motor fuel composition</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Sung, R.L.</p> <p>1989-09-26</p> <p>This patent describes a composition. It is obtained by reacting, at a temperature of 30{sup 0}C-200C 0.5-2.5 moles of one or more aliphatic carboxylic acids selected from the group consisting of formic, acetic, propionic, butyric, isobutyric, valeric, pivalic, acrylic, propiolie, methacylic, crotonic, isocrfotonic, maleic and fumaric acid; and 0.5-1.5 moles of a polyoxyalkylene diamine.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=ma&pg=2&id=EJ1021842','ERIC'); return false;" href="http://eric.ed.gov/?q=ma&pg=2&id=EJ1021842"><span id="translatedtitle">Learning about Inclusion by Listening to Ma<span class="hlt">ori</span></span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Berryman, Mere; Woller, Paul</p> <p>2013-01-01</p> <p>Behavioural and learning difficulties experienced by students from minoritised cultural groups often arise because their cultural beliefs, values and preferred practices differ markedly from those of their teachers and their school. Research in New Zealand has shown that if inclusive education is to have real meaning for these students and their</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013prpl.conf2S057P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013prpl.conf2S057P"><span id="translatedtitle">Detections of a precessing hotspot in FU <span class="hlt">Ori</span>?</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Powell, Stacie; Latham, David; Irwin, Mike; Bouvier, Jerome; Clarke, Cathie; Facchini, Stefano</p> <p>2013-07-01</p> <p>FU Orionis systems are young stars undergoing outbursts of disc accretion and where the optical spectrum contains lines associated with both the disc photosphere and a wind component. Previous observations of the prototype FU Orionis by Herbig et al. (2003) have suggested that the photospheric lines are modulated with a period of 3.5 d corresponding to a non-axisymmetric shift from blue to red velocities in the average line profiles. We have re-observed the system at higher spectral resolution with SOPHIE and TRES, by monitoring variations of optical line profiles over 21 nights in 2007 and 35 nights in 2013 and have found periods of 3.6 and 3.2 d in the disc components respectively, consistent with the above: this implies variability mechanisms that are stable over at least 15 years, we tentatively ascribe this to an orbiting hotspot in the disc. In addition we have found that the variations in the photospheric absorption lines are confined to the blue wing of the line, centered on velocities of -9 and -60 km/s in 2007 and 2013 respectively. Consequently, we discuss the possibility of an embedded hot Jupiter precessing on an inclined orbit to explain the different velocities of the detected periodic signal between all three epochs.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1998larm.confE.106L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1998larm.confE.106L"><span id="translatedtitle">Spectral classification in the <span class="hlt">ORI</span> OB1 association.</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Levato, H.; Malaroda, S.; Morrell, N.</p> <p>1998-11-01</p> <p>We have classified 526 stars included by Warren and Hesser in their photometric study of the Orion Association made in the late seventies. The spectra recorded in the last decade on photographic plates were taken with the spectrographs at the 1.5 m and 1 m telescopes at CTIO and were classified in the MK system. We have discussed membership using our spectroscopic data and new proper motions. We have derived spectroscopic distances and reddening and we discussed the incidence of CP objects among the members of the association. We have also derived the projected axial rotation of each object.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=learning+AND+difficulties&pg=7&id=EJ1021842','ERIC'); return false;" href="http://eric.ed.gov/?q=learning+AND+difficulties&pg=7&id=EJ1021842"><span id="translatedtitle">Learning about Inclusion by Listening to Ma¯<span class="hlt">ori</span></span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Berryman, Mere; Woller, Paul</p> <p>2013-01-01</p> <p>Behavioural and learning difficulties experienced by students from minoritised cultural groups often arise because their cultural beliefs, values and preferred practices differ markedly from those of their teachers and their school. Research in New Zealand has shown that if inclusive education is to have real meaning for these students and their…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2007HDRTh........1M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2007HDRTh........1M"><span id="translatedtitle">Study of physical conditions in protoplanetary disks by interferometry. Theory, instrumentation and first observations. -- étude des conditions physiques dans les disques protoplanétaires par interférométrie. Thé<span class="hlt">orie</span>, instrumentation et premières observations.</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Malbet, Fabien</p> <p>2007-10-01</p> <p>Les étoiles se forment lors de l'effondrement de nuages de gaz et de poussière. Dans l'environnement proche de l'étoile naissante la matière se concentre dans un plan équatorial que l'on appelle disque protoplanétaire. Les astronomes pensent que les planètes se forment au sein de cette masse de gaz et de poussière orbitant autour de l'étoile. Pour sonder ces disques à des échelles correspondant aux orbites des futures planètes, il convient d'observer dans l'infrarouge à très haute résolution spatiale. L'interférométrie infrarouge est donc un outil idéal pour étudier les conditions physiques des disques protoplanétaires. Dans ce mémoire, je décris les premiers pas de l'interférométrie infrarouge, depuis la mise au point des petits interféromètres PTI et IOTA jusqu'à la construction de l'instrument AMBER au foyer de l'interféromètre du VLT. Je décris aussi les résultats d'une piste de recherche technologique particulièrement attrayante dans le cas de l'interférométrie infrarouge et issue des technologies des autoroutes de l'information: l'optique intégrée appliquée à la combinaison de plusieurs faisceaux en astronomie. Je montre ensuite comment à partir des observations obtenues à partir de ces instruments, il est possible de contraindre la physique des disques autour des étoiles jeunes. Gráce à la résolution spectrale nouvellement disponible sur ces instruments, pour la première fois nous pouvons séparer des phénomènes physiques aussi différents que l'accrétion de matière sur l'étoile et l'éjection de particules par des vents dont l'origine précise est encore mal connue. Les résultats présentés dans ce mémoire ont été obtenus principalement à partir d'observations sur les systèmes jeunes FU <span class="hlt">Ori</span> et MWC 297 effectuées par AMBER sur le VLTI, mais aussi par les petits interféromètres infrarouges PTI et IOTA. Je développe aussi les travaux de modélisation de la structure verticale des disques associés afin de montrer la richesse des renseignements obtenus. Finalement je trace les contours d'un programme de recherche qui permettra tout d'abord de maximiser le retour astrophysique sur un instrument comme le VLTI, puis d'obtenir de premières images interférométriques de ces environnements circumstellaires. Je propose aussi la réalisation d'un instrument de seconde génération qui permettra de fournir des images interférométriques détaillées de ces sources compactes par synthèse d'ouverture. Stars are forming when clouds of gas and dust collapse. In the close environment of the new star, the matter is concentrated in an equatorial plane which is called protoplanetary disk. The astronomers think that planets are formed within this mass of gas and dust orbiting around the star. To probe these disks at scales corresponding to the orbits of the future planets, it is necessary to observe at very high spatial resolution in the infrared wavelength domain. Infrared interferometry is therefore an ideal tool to study the physical conditions in protoplanetary disks. In this document, I describe the first steps of infrared interferometry, from the beginning of the small interferometers PTI and IOTA until the construction of the AMBER instrument at the focus of the VLT Interferometer. I describe also the results of a technological research track, particularly attractive in the case of infrared interferometry, and coming from the information freeway: the integrated optics applies to the combination of several beams in astronomy. I show then how from observations obtained from these instruments, it is possible to constrain the physics of disks around young stars. Thanks to the spectral resolution recently available on these instruments, for the first time, we can separate the physical phenomena as different as accretion of matter onto the star and the ejection of particles by winds whose precise origin is still not well known. The results presented in this document were obtained mainly from observations on the young systems FU <span class="hlt">Ori</span> and MWC 297 and performed by AMBER on the VLTI, but also by the small infrared interferometers PTI and IOTA. I tackle also the modeling of the vertical structure of those disks in order to show the wealth of obtained information. Finally I draw the contours of a research program that will allow first the VLTI astrophysical return to be maximized, and then the first interferometric images of these circumstellar environments to be obtained. I also propose to build a second generation instrument for the VLTI which will bring detailed interferometric images by aperture synthesis of these compact sources.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26441116','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26441116"><span id="translatedtitle">Neurotoxins: Current Concepts in Cosmetic Use on the Face and Neck--Lower Face.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wu, Douglas C; Fabi, Sabrina G; Goldman, Mitchel P</p> <p>2015-11-01</p> <p>Botulinum toxin A was Food and Drug Administration approved in 2002 for the temporary correction of glabellar frown lines. Since that time, a variety of neuromodulators have established a convincing profile for both safety and efficacy in the treatment hyperdynamic rhytides of the upper face. With increasing clinical experience and expertise, these applications have been expanded to include targeted treatment of muscles in both the mid and lower face. This article details common techniques using botulinum toxin to treat orbicularis <span class="hlt">oris</span>, depressor <span class="hlt">anguli</span> <span class="hlt">oris</span>, mentalis, and masseter muscles for the temporary correction of unwanted lower face hyperdynamic rhytides and facial contouring. Although we detail our suggested quantity of units per injection site based on onabotulinumtoxinA, all neuromodulators can be used in all of these suggested treatment areas with adjustment of the quantity of units based on the efficacy of the specific neuromodulator. A more compete discussion on the relative efficacy of all neuromodulators is beyond the scope of this article. PMID:26441116</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24851637','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24851637"><span id="translatedtitle">Asymmetric neonatal crying: microdeletion, infection or birth injury?--a case report.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kosi-Santi?, Kornelija; Rudan, Dijana; Bukovi?, Damir; Segregur, Jadranko; Wagner, Jasenka; Oreskovi?, Slavko; Zupi?, Tomislav; Radan, Mirjana</p> <p>2014-03-01</p> <p>Asymmetric neonatal crying is a rare minor congenital abnormality caused by unilateral agenesis or hypoplasia of depressor <span class="hlt">anguli</span> <span class="hlt">oris</span> muscle and depressor labii inferioris muscle. It is either an isolated clinical finding or one of the clinical findings included in several malformation syndromes linked to a microdeletion within a chromosomal region 22q11.2. Some malformations in that region are associated with serious cardiovascular anomalies. Nowadays, standard diagnostic techniques for detecting aberrations within the chromosomal region 22q11.2 are fluorescence in situ hybridization (FISH) and multiplex ligation probe amplification (MLPA). This short report describes an eutrophic female newborn whose both lip corners are symmetrically positioned while at rest; while crying, left lip corner and left half of the lower lip are falling. She also has partial bilateral syndactyly between second and third toe, open foramen ovale and by ultrasound detected hyperechogenic region in the thalamus and brain parenchyme. Aiming to investigate etiopathogenesis of the newborn asymmetric crying and accompanying minor abnormalities, we have tried to verify or exclude: microdeletion syndrome, TORCH infection and birth injury. Recognising such a paresis soon after the delivery is of great importance and can be helpful in detecting other accompanying anomalies, especially cardiovascular anomalies. PMID:24851637</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26384622','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26384622"><span id="translatedtitle">Specificity of facelift surgery, including mid facelift, in case of facial palsy.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Le Louarn, C</p> <p>2015-10-01</p> <p>The asymmetry created by the facial palsy is of course a cause of demand for facelift surgery. As this lifting action is specific and different from the standard procedures, 3zones of analysis are proposed: first the frontal and temporal areas with the direct eyebrow lift, second the neck and jawline with action on the depressor <span class="hlt">anguli</span> <span class="hlt">oris</span> for the non-paralyzed side and the anterior sub SMAS dissection and third the midface. A new and more simple technique of concentric malar lift is proposed. The first publication on concentric malar lift was made 11years ago. Midface rejuvenation stays very challenging. As a proof of that, many authors prefer a partial rejuvenation of mid face with fat reinjection, with no effect on skin excess, even if all the MRI studies demonstrated no fat loss with time but only fat transfer. This proves that midface lift did not acquire enough simplicity, reliability to become a standard procedure. Six hundred concentric malar lift later, a technical simplification validated with 110patients and 2years of follow-up is proposed. The improvement is due to a new way to pass the threads deeply on the bone, using permanent barbed sutures. This surgery becomes easier and more efficient. PMID:26384622</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li class="active"><span>10</span></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_10 --> <div id="page_11" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li class="active"><span>11</span></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="201"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4042050','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4042050"><span id="translatedtitle">Intraoperative blood loss during surgical treatment of low-rectal cancer by abdominosacral resection is higher than during extra-<span class="hlt">levator</span> abdominosacral amputation of the rectum</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2014-01-01</p> <p>Introduction Abdominosacral resection (ASR) usually required blood transfusions, which are virtually no longer in use in the modified abdominosacral amputation of the rectum (ASAR). The aim of this study was to compare the intra-operative bleeding in low-rectal patients subjected to ASR or ASAR. Material and methods The study included low-rectal cancer patients subjected to ASR (n = 114) or ASAR (n = 46) who were retrospectively compared in terms of: 1) the frequency of blood transfusions during surgery and up to 24 h thereafter; 2) the volume of intraoperative blood loss (ml of blood transfused) during surgery and up to 24 h thereafter; 3) hemoglobin concentrations (Hb) 1, 3 and 5 days after surgery; 4) the duration of hospitalization. Results Blood transfusions were necessary in 107 ASR patients but in none of those subjected to ASAR (p < 0.001). Median blood loss in the ASR group was 800 ml (range: 1004500 ml). The differences between the groups in median Hb determined 1, 3 and 5 days following surgery were insignificant. The proportions of patients with abnormal values of Hb, however, were significantly higher in the ASR group on postoperative days 1 and 3 (day 1: 71.9% vs. 19.6% in the ASAR group, p = 0.025; day 3: 57.% vs. 13.0%, p = 0.009). Average postoperative hospitalization in ASR patients was 13 days compared to 9 days in the ASAR group (p = 0.031). Conclusions Abdominosacral amputation of the rectum predominates over ASR in terms of the prevention of intra- and postoperative bleeding due to the properly defined surgical plane in low-rectal cancer patients. PMID:24904664</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/7368706','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/7368706"><span id="translatedtitle">Oak Ridge Environmental Information System (<span class="hlt">ORIES</span>) site workstation information packet for OREIS V1. 2</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Voorhees, L.D.; McCord, R.A.; Durfee, R.C.; Land, M.L.; Olson, R.J.; Palmer, M.R.; Thomas, J.K.; Tinnel, E.P.; Zygmunt, B.C.</p> <p>1993-02-01</p> <p>The OREIS site workstation information packet was developed to accompany the OREIS site workstations, which are being delivered to the Environmental Restoration programs at the five DOE-OR sites. The packet is written specifically for the Site ER program staff at each of the five Sites who have been designated the OREIS contact by their ER program manager, and is not intended for general distribution. The packet provides an overview of the components of OREIS, points to more detailed information provided in the accompanying vendor and OREIS developed manuals, and includes information on training opportunities and user support.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014yCat..74351671W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014yCat..74351671W"><span id="translatedtitle">VizieR Online Data Catalog: SCUBA-2 850um survey in ? <span class="hlt">Ori</span> cluster (Williams+, 2013)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Williams, J. P.; Cieza, L. A.; Andrews, S. M.; Coulson, I. M.; Barger, A. J.; Casey, C. M.; Chen, C.-C.; Cowie, L. L.; Koss, M.; Lee, N.; Sanders, D. B.</p> <p>2014-09-01</p> <p>We observed a circular region with diameter 0.5 (about the diameter of the full Moon) towards the sigma Orionis cluster at 850um. The data were taken in queue mode over numerous observing runs from 2011 October to 2013 January (programme IDs: M11BH02A, M12AH02A and M12BH47A) in median (JCMT band 3) weather conditions, defined by the zenith optical depths at 225GHz lying between 0.08 and 0.12. This corresponds to precipitable water vapour levels ~2-3mm and zenith optical depths at 850um ~0.25-0.35. The total on-source integration time was 31h. (1 data file).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=19920028482&hterms=spectrophotometry+solutions&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D90%26Ntt%3Dspectrophotometry%2Bsolutions','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=19920028482&hterms=spectrophotometry+solutions&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D90%26Ntt%3Dspectrophotometry%2Bsolutions"><span id="translatedtitle">The 11 year history of starspots on V1149 <span class="hlt">Ori</span> = HD 37824</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Hall, Douglas S.; Fekel, Francis C.; Henry, Gregory W.; Barksdale, William S.</p> <p>1991-01-01</p> <p>All available radial-velocity measures, published and unpublished, yield an improved period and a new (assumed circular) solution. The period is 53.58 d +/- 0.02 d, and conjunction (K1 giant in front) was at 2 444 325.93 +/- 0.12 d. Eleven years of V-band photometry, published and unpublished, between 1978-1979 and 1989-1990 are analyzed. Eighteen data groups are fit with a two-spot light-curve-modeling technique. Six spots existing sometime during the 11 years are identified, and the 4-percent range of their rotation periods is used to estimate a differential rotation coefficient of k = 0.08 +/- 0.02. Observed lifetimes of those six spots are consistent with times calculated on the assumption that large spots are disrupted by the shear of differential rotation. The two best observed spots each lasted about five years.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015ATel.8147....1M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015ATel.8147....1M"><span id="translatedtitle">Spectroscopic identification of ASASSN-15qi as an FU <span class="hlt">Ori</span>-like object</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Maehara, Hiroyuki; Ayani, Kazuya; Itoh, Ryosuke; Takata, Koji; Kawabata, Koji S.</p> <p>2015-10-01</p> <p>We report spectroscopic observations of the optical transient ASASSN-15qi. This object was discovered by the All-Sky Automated Survey for Supernovae (ASAS-SN or "Assassin") at V=13.64 mag on 2015-10-03.27 and was classified as a possible YSO based on its association with an HII region (ASAS-SN Transients list; Shappee et al. 2014, ApJ, 788, 48). The object is identical to IPHAS J225608.82+583104.1 (r=16.66, i=15.59) and 2MASS J22560882+5831040 (J=13.704, H=12.923, K=12.647).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015IAUS..307..273M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015IAUS..307..273M"><span id="translatedtitle">Evidences for a large hot spot on the disk of Betelgeuse (α <span class="hlt">Ori</span>)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Montargès, M.; Kervella, P.; Perrin, G.; Chiavassa, A.; Le Bouquin, J. B.</p> <p>2015-01-01</p> <p>Massive evolved stars contribute to the chemical enrichment of the Galaxy. When they die as supernova but also through their mass loss during the several thousands of years of their red supergiant (RSG) phase. Unfortunately the mass loss mechanism remains poorly understood. Detailed study of the CSE and photosphere of nearby RSGs is required to constrain this scenario. Betelgeuse is the closest RSG (197 pc) and therefore has a large apparent diameter (~ 42 mas) which makes it a very interesting target. For several years, our team has lead a multi-wavelength and multi-scale observing program to characterize its mass loss. We will review here our recent results in near-infrared interferometry.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3624858','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3624858"><span id="translatedtitle">Intracortical circuits, sensorimotor integration and plasticity in human motor cortical projections to muscles of the lower face</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pilurzi, G; Hasan, A; Saifee, T A; Tolu, E; Rothwell, J C; Deriu, F</p> <p>2013-01-01</p> <p>Previous studies of the cortical control of human facial muscles documented the distribution of corticobulbar projections and the presence of intracortical inhibitory and facilitatory mechanisms. Yet surprisingly, given the importance and precision in control of facial expression, there have been no studies of the afferent modulation of corticobulbar excitability or of the plasticity of synaptic connections in the facial primary motor cortex (face M1). In 25 healthy volunteers, we used standard single- and paired-pulse transcranial magnetic stimulation (TMS) methods to probe motor-evoked potentials (MEPs), short-intracortical inhibition, intracortical facilitation, short-afferent and long-afferent inhibition and paired associative stimulation in relaxed and active depressor <span class="hlt">anguli</span> <span class="hlt">oris</span> muscles. Single-pulse TMS evoked bilateral MEPs at rest and during activity that were larger in contralateral muscles, confirming that corticobulbar projection to lower facial muscles is bilateral and asymmetric, with contralateral predominance. Both short-intracortical inhibition and intracortical facilitation were present bilaterally in resting and active conditions. Electrical stimulation of the facial nerve paired with a TMS pulse 5–200 ms later showed no short-afferent inhibition, but long-afferent inhibition was present. Paired associative stimulation tested with an electrical stimulation–TMS interval of 20 ms significantly facilitated MEPs for up to 30 min. The long-term potentiation, evoked for the first time in face M1, demonstrates that excitability of the facial motor cortex is prone to plastic changes after paired associative stimulation. Evaluation of intracortical circuits in both relaxed and active lower facial muscles as well as of plasticity in the facial motor cortex may provide further physiological insight into pathologies affecting the facial motor system. PMID:23297305</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4467658','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4467658"><span id="translatedtitle">IncobotulinumtoxinA in aesthetics: Russian multidisciplinary expert consensus recommendations</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Yutskovskaya, Yana; Gubanova, Elena; Khrustaleva, Irina; Atamanov, Vasiliy; Saybel, Anastasiya; Parsagashvili, Elena; Dmitrieva, Irina; Sanchez, Elena; Lapatina, Natalia; Korolkova, Tatiana; Saromytskaya, Alena; Goltsova, Elena; Satardinova, Elmira</p> <p>2015-01-01</p> <p>Background Although there are various international consensus recommendations on the use of botulinum neurotoxin type A (BoNT/A) in facial aesthetics, there are no global or Russian guidelines on the optimal dose of incobotulinumtoxinA, free from complexing proteins, within specific aesthetic indications. This article reports the outcomes of two expert consensus meetings, conducted to review and analyze efficacy and tolerability data for incobotulinumtoxinA in various facial aesthetic indications and to give expert consensus recommendations to ensure best clinical practice among Russian clinicians. Methods Thirteen dermatology and/or plastic surgery experts attended meetings held in Paris, France (November 2013), and Moscow, Russia (March 2014). The expert group reviewed and analyzed the existing evidence, consensus recommendations, and Russian experts extensive practical experience of incobotulinumtoxinA in aesthetics to reach consensus on optimal doses, potential dose adjustments, and injection sites of incobotulinumtoxinA for facial aesthetics. Results All experts developed guidance on the optimal doses for incobotulinumtoxinA treatment of different regions of the upper and lower face. The expert panel agreed that there are no differences in the efficacy and duration of the effect between the four BoNT/As that are commercially available for facial aesthetic indications in Russia and that, when administered correctly, all BoNT/As can achieve optimal results. Experts also agreed that nonresponse to BoNT/A can be caused by neutralizing antibodies. Conclusion On the basis of the scientific and clinical evidence available for incobotulinumtoxinA, coupled with the extensive clinical experience of the consensus group, experts recommended the optimal doses of incobotulinumtoxinA effective for treatment of wrinkles of the upper and lower face to achieve the expected aesthetic outcome. These first Russian guidelines on the optimal use of incobotulinumtoxinA for augmentation of glabellar lines, periorbital wrinkles, forehead lines, bunny lines, perioral wrinkles, depressor <span class="hlt">anguli</span> <span class="hlt">oris</span>, mentalis, masseters and platysmal bands, and performing the Nefertiti lift, are presented here. PMID:26089695</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/10141901','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/10141901"><span id="translatedtitle">Oak Ridge Environmental Information System (<span class="hlt">ORIES</span>) site workstation information packet for OREIS V1.2. Environmental Restoration Program</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Voorhees, L.D.; McCord, R.A.; Durfee, R.C.; Land, M.L.; Olson, R.J.; Palmer, M.R.; Thomas, J.K.; Tinnel, E.P.; Zygmunt, B.C.</p> <p>1993-02-01</p> <p>The OREIS site workstation information packet was developed to accompany the OREIS site workstations, which are being delivered to the Environmental Restoration programs at the five DOE-OR sites. The packet is written specifically for the Site ER program staff at each of the five Sites who have been designated the OREIS contact by their ER program manager, and is not intended for general distribution. The packet provides an overview of the components of OREIS, points to more detailed information provided in the accompanying vendor and OREIS developed manuals, and includes information on training opportunities and user support.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4335283','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4335283"><span id="translatedtitle">Allier thé<span class="hlt">orie</span> et pratique dans la lutte contre la pandémie du Sida</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Zerbo, Roger</p> <p>2014-01-01</p> <p>Le premier cas d'infection par le VIH a été notifié en 1986 au Burkina Faso. L'ignorance qui entourait cette infection et l'absence de traitement curatif a amplifié ses conséquences sociales et économiques. La mise en œuvre des interventions communautaire est un enjeu majeur actuel qui recommande la compréhension des logiques sociales endogènes qui influencent les comportements individuels et collectifs. C'est en cela que l'implication des sciences sociales dans la lutte contre les maladies, en particulier le Sida constitue un enjeu, en termes de définition et d'identification de leur contribution. Dans notre propos, nous pouvons mettre en évidence trois niveaux de contribution des sciences sociales, notamment la sociologie, l'anthropologie, la psychologie et dans une certaine mesure le droit et l’économie, à la prévention du Sida et la prise en charge des personnes infectées par le VIH. Il faut noter que ces disciplines contribuent à la lutte contre le VIH d'une part, par des réflexions et des éléments d'analyses constructives, et d'autre part, l'aptitude des porteurs de ces disciplines est parfois sollicitée pour l'efficacité de la mise en œuvre des actions et l'organisation des systèmes de soins. PMID:25722761</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014Azi.....2d..15N','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014Azi.....2d..15N"><span id="translatedtitle">Structure de l'univers - quand l'observation guide la thé<span class="hlt">orie</span>... ou pas</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Nazé, Yaël</p> <p></p> <p>The scientific method is often presented, e.g. to children, as a linear process, starting by a question and ending by the elaboration of a theory, with a few experiments in-between. The reality of the building of science is much more complex, with back-and-forth motions between theories and observations, with some intervention of technology and randomness. This complex process is not always correctly understood and assimilated, even amongst scientists. The hero cult, mixed with some revisionism, still exists despite in-depth historical studies. In this context, it may be useful to comparatively examine the reaction to crucial observations, their interpretation and their impact on the contemporaneous theory development. Four examples are presented here, all linked to the question of the 'construction of the heavens' but at different epochs.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=MOTOR+AND+CONTROL+AND+CENTER&id=EJ1015587','ERIC'); return false;" href="http://eric.ed.gov/?q=MOTOR+AND+CONTROL+AND+CENTER&id=EJ1015587"><span id="translatedtitle">A Biomechanical Modeling Study of the Effects of the Orbicularis <span class="hlt">Oris</span> Muscle and Jaw Posture on Lip Shape</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Stavness, Ian; Nazari, Mohammad Ali; Perrier, Pascal; Demolin, Didier; Payan, Yohan</p> <p>2013-01-01</p> <p>Purpose: The authors' general aim is to use biomechanical models of speech articulators to explore how possible variations in anatomical structure contribute to differences in articulatory strategies and phone systems across human populations. Specifically, they investigated 2 issues: (a) the link between lip muscle anatomy and variability in…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=skull&pg=2&id=EJ1015587','ERIC'); return false;" href="http://eric.ed.gov/?q=skull&pg=2&id=EJ1015587"><span id="translatedtitle">A Biomechanical Modeling Study of the Effects of the Orbicularis <span class="hlt">Oris</span> Muscle and Jaw Posture on Lip Shape</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Stavness, Ian; Nazari, Mohammad Ali; Perrier, Pascal; Demolin, Didier; Payan, Yohan</p> <p>2013-01-01</p> <p>Purpose: The authors' general aim is to use biomechanical models of speech articulators to explore how possible variations in anatomical structure contribute to differences in articulatory strategies and phone systems across human populations. Specifically, they investigated 2 issues: (a) the link between lip muscle anatomy and variability in</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015yCat..74503490D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015yCat..74503490D"><span id="translatedtitle">VizieR Online Data Catalog: 15 new brown dwarfs in Orion OB1a/25 <span class="hlt">Ori</span> group (Downes+, 2015)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Downes, J. J.; Roman-Zuniga, C.; Ballesteros-Paredes, J.; Mateu, C.; Briceno, C.; Hernandez, J.; Petr-Gotzens, M. G.; Calvet, N.; Hartmann, L.; Mauco, K.</p> <p>2015-11-01</p> <p>For this work, we studied 21 targets from the sample of photometric BD candidates with expected spectral types between M6 and L1, obtained during the survey of the 25 Orionis group and its surroundings carried out by Downes et al. (2014, Cat. J/MNRAS/444/1793). We have carried out the spectroscopic observations of the 21 candidates with the OSIRIS instrument at the Gran Telescopio de Canarias (GTC). (3 data files).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2010AnPh...34b...1K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2010AnPh...34b...1K"><span id="translatedtitle">Les métamatériaux, des micro-ondes à l'optique : thé<span class="hlt">orie</span> et applications</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kante, B.</p> <p>2010-04-01</p> <p>Cet article constitue une contribution originale et importante à la compréhension à la fois théorique et expérimentale des métamatériaux en micro-ondes et en infrarouge. Nous avons réalisé et caractérisé sur silicium des nano-structures metallo-diélectriques, briques de base des métamatériaux infrarouge et optique. Des caractérisations optiques exhaustives ont été réalisées pour la première fois sur ces structures en amplitude et en phase par interférométrie. Des topologies plus simples de métamatériaux d’un point de vue technologique et des performances optiques ont été introduites, et leur potentiel démontré dans la réalisation de fonctions aussi complexes que la réfraction négative, le couplage de mode plasmoniques, les nano senseurs pour la biologie et l’invisibilité électromagnétique en infrarouge. Les transformations d’espace, et le nouveau paradigme qu’elles offrent à l’optique, rendant possible une ingénierie de l’espace pour les photons ainsi que leur implémentation par métamatériaux ont été présentés par la première démonstration expérimentale d’une cape d’invisibilité non magnétique.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4371235','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4371235"><span id="translatedtitle">The hunt for origins of DNA replication in multicellular eukaryotes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Urban, John M.; Foulk, Michael S.; Casella, Cinzia</p> <p>2015-01-01</p> <p>Origins of DNA replication (<span class="hlt">ORIs</span>) occur at defined regions in the genome. Although DNA sequence defines the position of <span class="hlt">ORIs</span> in budding yeast, the factors for <span class="hlt">ORI</span> specification remain elusive in metazoa. Several methods have been used recently to map <span class="hlt">ORIs</span> in metazoan genomes with the hope that features for <span class="hlt">ORI</span> specification might emerge. These methods are reviewed here with analysis of their advantages and shortcomings. The various factors that may influence <span class="hlt">ORI</span> selection for initiation of DNA replication are discussed. PMID:25926981</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2008SPIE.6842E..1UR','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2008SPIE.6842E..1UR"><span id="translatedtitle">Optical stimulation of the facial nerve: a surgical tool?</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Richter, Claus-Peter; Teudt, Ingo Ulrik; Nevel, Adam E.; Izzo, Agnella D.; Walsh, Joseph T., Jr.</p> <p>2008-02-01</p> <p>One sequela of skull base surgery is the iatrogenic damage to cranial nerves. Devices that stimulate nerves with electric current can assist in the nerve identification. Contemporary devices have two main limitations: (1) the physical contact of the stimulating electrode and (2) the spread of the current through the tissue. In contrast to electrical stimulation, pulsed infrared optical radiation can be used to safely and selectively stimulate neural tissue. Stimulation and screening of the nerve is possible without making physical contact. The gerbil facial nerve was irradiated with 250-?s-long pulses of 2.12 ?m radiation delivered via a 600-?m-diameter optical fiber at a repetition rate of 2 Hz. Muscle action potentials were recorded with intradermal electrodes. Nerve samples were examined for possible tissue damage. Eight facial nerves were stimulated with radiant exposures between 0.71-1.77 J/cm2, resulting in compound muscle action potentials (CmAPs) that were simultaneously measured at the m. orbicularis oculi, m. <span class="hlt">levator</span> nasolabialis, and m. orbicularis <span class="hlt">oris</span>. Resulting CmAP amplitudes were 0.3-0.4 mV, 0.15-1.4 mV and 0.3-2.3 mV, respectively, depending on the radial location of the optical fiber and the radiant exposure. Individual nerve branches were also stimulated, resulting in CmAP amplitudes between 0.2 and 1.6 mV. Histology revealed tissue damage at radiant exposures of 2.2 J/cm2, but no apparent damage at radiant exposures of 2.0 J/cm2.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=muscles+AND+human+AND+body&pg=5&id=EJ951485','ERIC'); return false;" href="http://eric.ed.gov/?q=muscles+AND+human+AND+body&pg=5&id=EJ951485"><span id="translatedtitle">Three-Dimensional Magnetic Resonance Imaging of Velopharyngeal Structures</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Bae, Youkyung; Kuehn, David P.; Sutton, Bradley P.; Conway, Charles A.; Perry, Jamie L.</p> <p>2011-01-01</p> <p>Purpose: To report the feasibility of using a 3-dimensional (3D) magnetic resonance imaging (MRI) protocol for examining velopharyngeal structures. Using collected 3D MRI data, the authors investigated the effect of sex on the midsagittal velopharyngeal structures and the <span class="hlt">levator</span> veli palatini (<span class="hlt">levator</span>) muscle configurations. Method: Ten Caucasian…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=muscle&pg=5&id=EJ951485','ERIC'); return false;" href="http://eric.ed.gov/?q=muscle&pg=5&id=EJ951485"><span id="translatedtitle">Three-Dimensional Magnetic Resonance Imaging of Velopharyngeal Structures</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Bae, Youkyung; Kuehn, David P.; Sutton, Bradley P.; Conway, Charles A.; Perry, Jamie L.</p> <p>2011-01-01</p> <p>Purpose: To report the feasibility of using a 3-dimensional (3D) magnetic resonance imaging (MRI) protocol for examining velopharyngeal structures. Using collected 3D MRI data, the authors investigated the effect of sex on the midsagittal velopharyngeal structures and the <span class="hlt">levator</span> veli palatini (<span class="hlt">levator</span>) muscle configurations. Method: Ten Caucasian</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25556104','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25556104"><span id="translatedtitle">Nanostructured lipid carriers used for oral delivery of oridonin: an effect of ligand modification on absorption.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Zhou, Xiaotong; Zhang, Xingwang; Ye, Yanghuan; Zhang, Tianpeng; Wang, Huan; Ma, Zhiguo; Wu, Baojian</p> <p>2015-02-20</p> <p>Oridonin (<span class="hlt">Ori</span>) is a natural compound with notable anti-inflammation and anti-cancer activities. However, therapeutic use of this compound is limited by its poor solubility and low bioavailability. Here a novel biotin-modified nanostructured lipid carrier (NLC) was developed to enhance the bioavailability of <span class="hlt">Ori</span>. The effect of ligand (biotin) modification on oral absorption of <span class="hlt">Ori</span> encapsulated in NLCs was also explored. <span class="hlt">Ori</span>-loaded NLCs (<span class="hlt">Ori</span>-NLCs) were prepared by the melt dispersion-high pressure homogenization method. Biotin modification of <span class="hlt">Ori</span>-NLCs was achieved by EDC and NHS in aqueous phase. The obtained biotin-decorated <span class="hlt">Ori</span>-NLCs (Bio-<span class="hlt">Ori</span>-NLCs) were 144.9nm in size with an entrapment efficiency of 49.54% and a drug load of 4.81%. Oral bioavailability was enhanced by use of Bio-<span class="hlt">Ori</span>-NLCs with a relative bioavailability of 171.01%, while the value of non-modified <span class="hlt">Ori</span>-NLCs was improved to 143.48%. Intestinal perfusion showed that <span class="hlt">Ori</span> solution unexpectedly exhibited a moderate permeability, indicating that permeability was not a limiting factor of <span class="hlt">Ori</span> absorption. <span class="hlt">Ori</span> could be rapidly metabolized that was the main cause of low bioavailability. However, there was a difference in the enhancement of bioavailability between Bio-<span class="hlt">Ori</span>-NLCs and conventional NLCs. Although severe lipolyses happened both on Bio-<span class="hlt">Ori</span>-NLCs and non-modified NLCs, the performance of Bio-<span class="hlt">Ori</span>-NLCs in the bioavailability improvement was more significant. Overall, Bio-<span class="hlt">Ori</span>-NLCs can further promote the oral absorption of <span class="hlt">Ori</span> by a ligand-mediated active transport. It may be a promising carrier for the oral delivery of <span class="hlt">Ori</span>. PMID:25556104</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li class="active"><span>11</span></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_11 --> <div id="page_12" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li class="active"><span>12</span></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="221"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3432843','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3432843"><span id="translatedtitle">The Olympic Regeneration in East London (<span class="hlt">ORi</span>EL) study: protocol for a prospective controlled quasi-experiment to evaluate the impact of urban regeneration on young people and their families</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Smith, Neil R; Clark, Charlotte; Fahy, Amanda E; Tharmaratnam, Vanathi; Lewis, Daniel J; Thompson, Claire; Renton, Adrian; Moore, Derek G; Bhui, Kamaldeep S; Taylor, Stephanie J C; Eldridge, Sandra; Petticrew, Mark; Greenhalgh, Tricia; Stansfeld, Stephen A; Cummins, Steven</p> <p>2012-01-01</p> <p>Introduction Recent systematic reviews suggest that there is a dearth of evidence on the effectiveness of large-scale urban regeneration programmes in improving health and well-being and alleviating health inequalities. The development of the Olympic Park in Stratford for the London 2012 Olympic and Paralympic Games provides the opportunity to take advantage of a natural experiment to examine the impact of large-scale urban regeneration on the health and well-being of young people and their families. Design and methods A prospective school-based survey of adolescents (11–12 years) with parent data collected through face-to-face interviews at home. Adolescents will be recruited from six randomly selected schools in an area receiving large-scale urban regeneration (London Borough of Newham) and compared with adolescents in 18 schools in three comparison areas with no equivalent regeneration (London Boroughs of Tower Hamlets, Hackney and Barking & Dagenham). Baseline data will be completed prior to the start of the London Olympics (July 2012) with follow-up at 6 and 18 months postintervention. Primary outcomes are: pre–post change in adolescent and parent mental health and well-being, physical activity and parental employment status. Secondary outcomes include: pre–post change in social cohesion, smoking, alcohol use, diet and body mass index. The study will account for individual and environmental contextual effects in evaluating changes to identified outcomes. A nested longitudinal qualitative study will explore families’ experiences of regeneration in order to unpack the process by which regeneration impacts on health and well-being. Ethics and dissemination The study has approval from Queen Mary University of London Ethics Committee (QMREC2011/40), the Association of Directors of Children's Services (RGE110927) and the London Boroughs Research Governance Framework (CERGF113). Fieldworkers have had advanced Criminal Records Bureau clearance. Findings will be disseminated through peer-reviewed publications, national and international conferences, through participating schools and the study website (http://www.orielproject.co.uk). PMID:22936822</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016CRPhy..17..237B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016CRPhy..17..237B"><span id="translatedtitle">Métallurgie fondamentale et métallurgie numérique : l'héritage de Jacques Friedel dans la thé<span class="hlt">orie</span> de la plasticité des métaux et alliages</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bréchet, Yves</p> <p>2016-03-01</p> <p>Jacques Friedel's contribution to the theory of plasticity is described, as well as the more recent developments it inspired. It involves the microscopic properties of dislocations as well as macroscopic effects. The evolution of fundamental metallurgy toward numerical metallurgy is discussed, and Friedel's point of view on numerical methods is analyzed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/11254974','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/11254974"><span id="translatedtitle">The Escherichia coli SeqA protein binds specifically to two sites in fully and hemimethylated <span class="hlt">ori</span>C and has the capacity to inhibit DNA replication and affect chromosome topology.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Skarstad, K; Torheim, N; Wold, S; Lurz, R; Messer, W; Fossum, S; Bach, T</p> <p>2001-01-01</p> <p>The SeqA protein was identified as a factor that prevents reinitiation of newly replicated, hemimethylated origins. SeqA also seems to inhibit initiation of fully methylated origins, thus contributing to the regulation of chromosomal replication. The SeqA protein was found to bind to two sites in the left part of the origin, near the AT-rich region where strand separation takes place during initiation of replication. The same binding sites seemed to be preferred irrespective of whether the origin was in the newly replicated (hemimethylated) state or not. In addition to binding specifically to groups of GATC sites, the SeqA protein was capable of interacting non-specifically with negatively supercoiled DNA, restraining the supercoils in a fashion similar to that seen with histone-like protein HU. The restraint of supercoils by SeqA was, in contrast to that of HU, cooperative. PMID:11254974</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=249462','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=249462"><span id="translatedtitle">The Epstein-Barr virus (EBV) <span class="hlt">ORI</span>1yt enhancer is not B-cell specific and does not respond synergistically to the EBV transcription factors R and Z.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Gruffat, H; Moreno, N; Sergeant, A</p> <p>1990-01-01</p> <p>The Epstein-Barr virus DR promoter is located upstream of the PstI repeats, and in addition to the TATA box, it contains an upstream region (positions -69 to -220) responsive to EB1 (Z) (the BZLF1-encoded transcription factor) and an enhancer with two functionally distinct domains, A and B. Domain B has been described as a B-cell-specific EB1-responsive element (P. M. Lieberman, J. M. Hardwick, and S. D. Hayward, J. Virol. 63:3040-3050, 1989) activated synergistically by EB1 and R, an EBV early product encoded by the open reading frame BRLF1 (M. A. Cox, J. Leahy, and J. M. Hardwick, J. Virol. 64:313-321, 1990). We show here that domain B is an R-responsive element in HeLa cells and is therefore not an EB1-responsive B-cell-specific element. However, there is an EB1-binding site (ZRE-B) located within the R-responsive enhancer region. ZRE-B can be deleted without affecting the R-dependent enhancer activity. Moreover, there is no cooperation or synergy between R and EB1 when activating the B domain (ZRE-B plus the R-responsive element) positioned as an enhancer. ZRE-B is therefore not part of the R-inducible enhancer. We have tested several subregions of the DR enhancer B domain, either alone or in combination, for their capacity to transmit the R-activating signal to the rabbit beta-globin promoter. We found that the R-responsive element is composed of four protoenhancers that span the whole B domain. These protoenhancers alone are weakly or not responsive to R. One of the protoenhancers contains the overlapping palindromes 5'-TTGTCCcgtGGACAAaTGTCC-3'. However, one palindrome, either alone or duplicated, or the overlapping palindromes did not respond to R. Images PMID:2159545</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1998CRASE.327..253D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1998CRASE.327..253D"><span id="translatedtitle">Modèle d'aide à la gestion des eaux souterraines (MAGES). 1. Thé<span class="hlt">orie</span> du modèle numérique de transport des contaminants</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Delay, Frédérick; Banton, Olivier; Porel, Gilles</p> <p>1998-08-01</p> <p>MAGES is software for forecasting pollution hazards of groundwater which is in the process of development at INRS-Eau (Canada). The main distinctive feature of the model is the use of stationary truncated temporal moment equations instead of the classical time dependent advection-dispersion equation to solve the transport of contaminants. The aim of this work is to describe the theory of truncated temporal moment equations and to show how the curves of the concentration versus time can be calculated from temporal moments. The discrete method used to solve the equations and its stability is also discussed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1203731','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1203731"><span id="translatedtitle">Extragenic Suppression and Synthetic Lethality among Chlamydomonas Reinhardtii Mutants Resistant to anti-Microtubule Drugs</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>James, S. W.; Silflow, C. D.; Thompson, M. D.; Ranum, LPW.; Lefebvre, P. A.</p> <p>1989-01-01</p> <p>The antimicrotubule agents oryzalin (<span class="hlt">ORY</span>), colchicine (COL) and taxol (TAX) were used to select three recessive, conditional lethal (ts(-)) mutants which defined two new essential loci, <span class="hlt">ory</span>1 and cor1. The two <span class="hlt">ory</span>1 mutants conferred resistance to <span class="hlt">ORY</span>, TAX, and COL; the cor1 mutant conferred resistance only to COL. Each of the mutants displayed wild-type sensitivity to a number of unrelated inhibitors. Assembly and disassembly of flagellar microtubules in the <span class="hlt">ory</span>1 mutants displayed wild-type sensitivity to <span class="hlt">ORY</span> and COL, suggesting that the <span class="hlt">ory</span>1 gene product either does not participate in these processes or the <span class="hlt">ory</span>1 gene product alone is not sufficient to confer resistance. The <span class="hlt">ory</span>1 locus mapped to linkage group X; cor1 was mapped to the left arm of linkage group XII. A synthetic lethal interaction was observed between <span class="hlt">ory</span>1 and cor1 mutations, i.e., inferred <span class="hlt">ory</span>1 cor1 double mutants were inviable at the permissive temperature. The conditional lethal phenotype of <span class="hlt">ory</span>1-1 was used to select many spontaneous TS(+) revertants, which arose at high frequencies. Genetic and phenotypic characterization of the revertants demonstrated that (1) the revertants fell into four phenotypic classes, including some which conferred supersensitivity to <span class="hlt">ORY</span> and others which conferred cold-sensitive lethality, (2) reversion was caused in most or all cases by extragenic suppressors, (3) suppressor mutations displayed complex behavior in heterozygous (sup/+) diploids, (4) many different loci may be capable of suppressing <span class="hlt">ory</span>1 mutants, and (5) suppressors of <span class="hlt">ory</span>1-1 efficiently suppressed an independently isolated allele, <span class="hlt">ory</span>1-2. Taken together the <span class="hlt">ory</span>1, cor1, and suppressor mutations identify a number of interacting loci involved in essential cellular processes which are specifically susceptible to antimicrotubule agents. PMID:2569432</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=187779&keyword=finasteride&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=58602447&CFTOKEN=76450795','EPA-EIMS'); return false;" href="http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=187779&keyword=finasteride&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=58602447&CFTOKEN=76450795"><span id="translatedtitle">The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo and androgen and antiandrogen responses: Phase-2 dose-response studies</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>DESIGN: The Hershberger bioassay is designed to identify suspected androgens and antiandrogens based on changes in the weights of five androgen-responsive tissues (ventral prostate, paired seminal vesicles and coagulating glands, the <span class="hlt">levator</span> ani and bulbocavernosus muscles, the g...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-512.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-512.pdf"><span id="translatedtitle">42 CFR 93.512 - Discovery.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative Actions Hearing...; (2) Analyses and summaries prepared in conjunction with the inquiry, investigation, <span class="hlt">ORI</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title42-vol1/pdf/CFR-2014-title42-vol1-sec93-404.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title42-vol1/pdf/CFR-2014-title42-vol1-sec93-404.pdf"><span id="translatedtitle">42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... administrative actions. After completing its review, <span class="hlt">ORI</span> either closes the case without a finding of research... obtained by <span class="hlt">ORI</span> during its review; or (b) Recommends that HHS seek to settle the case....</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title42-vol1/pdf/CFR-2013-title42-vol1-sec93-404.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title42-vol1/pdf/CFR-2013-title42-vol1-sec93-404.pdf"><span id="translatedtitle">42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>... administrative actions. After completing its review, <span class="hlt">ORI</span> either closes the case without a finding of research... obtained by <span class="hlt">ORI</span> during its review; or (b) Recommends that HHS seek to settle the case....</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-404.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-404.pdf"><span id="translatedtitle">42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... administrative actions. After completing its review, <span class="hlt">ORI</span> either closes the case without a finding of research... obtained by <span class="hlt">ORI</span> during its review; or (b) Recommends that HHS seek to settle the case....</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23163746','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23163746"><span id="translatedtitle">In vitro and in vivo studies of galactose-modified liver-targeting liposomes.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Guo, Bohong; Cheng, Yi; Li, Niying; Li, Xiaofang; Jin, Miaozhen; Li, Ting; Li, Jin</p> <p>2012-11-19</p> <p>Oridonin (<span class="hlt">ORI</span>) is a bioactive diterpenoid compound extracted from the well known Chinese traditional medicine Rabdosia rubescens. The aim of this study was to prepare <span class="hlt">ORI</span> loaded liposomes surface-modified with galactose (NOH-<span class="hlt">ORI</span>-LP) and evaluate their characteristics compared with <span class="hlt">ORI</span> loaded liposomes (<span class="hlt">ORI</span>-LP) and <span class="hlt">ORI</span> solution in vitro and in vivo. The NOH-<span class="hlt">ORI</span>-LP was prepared by ethanol injection method. The NOH-<span class="hlt">ORI</span>-LP was characterized by their morphology, particle size, zeta potential and encapsulation efficiency. The concentration of <span class="hlt">ORI</span> in plasma and tissues at different sampling time points were determined. The liver concentration-time curves of NOH-<span class="hlt">ORI</span>-LP in mice were determined, and the pharmacokinetic parameters were calculated and compared by statistical analysis. Our data revealed that NOH-<span class="hlt">ORI</span>-LP has a particle size of about (173??12) nm. The particles exhibit a negative electrical charge (-31.5??1.6 mV), and possess high encapsulation efficiency (94.1??1.2%). There were significantly different parameters of k(10) and area under the plasma concentration-time curve (AUC(0-t)) between liposomes and solution. The mean residence time (MRT(0-t)) in plasma of NOH-<span class="hlt">ORI</span>-LP was 5.56 times longer than that of solution. Compared with solution, NOH-<span class="hlt">ORI</span>-LP delivered about 4.28 times higher <span class="hlt">ORI</span> into liver. Thus, an optimum intravenous galactose-modified liposome formulation for <span class="hlt">ORI</span> could be developed as an alternative to the commercial <span class="hlt">ORI</span> preparations. PMID:23163746</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-01-03/pdf/2011-33651.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-01-03/pdf/2011-33651.pdf"><span id="translatedtitle">77 FR 125 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-01-03</p> <p>... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (<span class="hlt">ORI</span>) has... conducted by <span class="hlt">ORI</span> in its oversight review, <span class="hlt">ORI</span> found that Dr. Mahesh Visvanathan, Research...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-04-13/pdf/2012-8903.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-04-13/pdf/2012-8903.pdf"><span id="translatedtitle">77 FR 22320 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-04-13</p> <p>... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (<span class="hlt">ORI</span>) has... additional analysis conducted by <span class="hlt">ORI</span> in its oversight review, <span class="hlt">ORI</span> found that Dr. Peter J. Francis,...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2013-11-12/pdf/2013-26991.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2013-11-12/pdf/2013-26991.pdf"><span id="translatedtitle">78 FR 67363 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2013-11-12</p> <p>... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (<span class="hlt">ORI</span>) has...--Canada (WU) and <span class="hlt">ORI</span>'s subsequent oversight analysis, <span class="hlt">ORI</span> found that Dr. Hao Wang, former...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-12-28/pdf/2012-31275.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-12-28/pdf/2012-31275.pdf"><span id="translatedtitle">77 FR 76491 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-12-28</p> <p>... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (<span class="hlt">ORI</span>) has... conducted by <span class="hlt">ORI</span> in its oversight review, <span class="hlt">ORI</span> found that Dr. Martin Biosse-Duplan, former Research...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-09-06/pdf/2012-21992.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-09-06/pdf/2012-21992.pdf"><span id="translatedtitle">77 FR 54917 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-09-06</p> <p>...Notice is hereby given that the Office of Research Integrity (<span class="hlt">ORI</span>) has taken final action in the following case: Marc Hauser, Ph.D., Harvard University: Based on the report of an investigation conducted by Harvard University (Harvard) and additional analysis conducted by <span class="hlt">ORI</span> in its oversight review, <span class="hlt">ORI</span> found that Dr. Marc Hauser, former Professor, Department of Psychology, Harvard, engaged in......</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2011-12-23/pdf/2011-32914.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2011-12-23/pdf/2011-32914.pdf"><span id="translatedtitle">76 FR 80371 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2011-12-23</p> <p>...Notice is hereby given that the Office of Research Integrity (<span class="hlt">ORI</span>) has taken final action in the following case: Gerald Lushington, Ph.D., Kansas University: Based on an inquiry conducted and written admission obtained by Kansas University (KU) and additional analysis conducted by <span class="hlt">ORI</span> in its oversight review, <span class="hlt">ORI</span> found that Dr. Gerald Lushington, Director of the K-INBRE \\1\\ Bioinformatics Core......</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2011-11-04/pdf/2011-28619.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2011-11-04/pdf/2011-28619.pdf"><span id="translatedtitle">76 FR 68460 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2011-11-04</p> <p>...Notice is hereby given that the Office of Research Integrity (<span class="hlt">ORI</span>) has taken final action in the following case: Jayant Jagannathan, M.D., University of Virginia Medical Center: Based on the report of an investigation conducted by the University of Virginia (UVA) and additional analysis conducted by <span class="hlt">ORI</span> in its oversight review, <span class="hlt">ORI</span> found that Dr. Jayant Jagannathan, former Resident Physician......</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4468827','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4468827"><span id="translatedtitle">Redefining bacterial origins of replication as centralized information processors</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Marczynski, Gregory T.; Rolain, Thomas; Taylor, James A.</p> <p>2015-01-01</p> <p>In this review we stress the differences between eukaryotes and bacteria with respect to their different cell cycles, replication mechanisms and genome organizations. One of the most basic and underappreciated differences is that a bacterial chromosome uses only one <span class="hlt">ori</span> while eukaryotic chromosome uses multiple <span class="hlt">oris</span>. Consequently, eukaryotic <span class="hlt">oris</span> work redundantly in a cell cycle divided into separate phases: First inactive replication proteins assemble on eukaryotic <span class="hlt">oris</span>, and then they await conditions (in the separate “S-phase”) that activate only the <span class="hlt">ori</span>-bound and pre-assembled replication proteins. S-phase activation (without re-assembly) ensures that a eukaryotic <span class="hlt">ori</span> “fires” (starts replication) only once and that each chromosome consistently duplicates only once per cell cycle. This precise chromosome duplication does not require precise multiple <span class="hlt">ori</span> firing in S-phase. A eukaryotic <span class="hlt">ori</span> can fire early, late or not at all. The single bacterial <span class="hlt">ori</span> has no such margin for error and a comparable imprecision is lethal. Single <span class="hlt">ori</span> usage is not more primitive; it is a totally different strategy that distinguishes bacteria. We further argue that strong evolutionary pressures created more sophisticated single <span class="hlt">ori</span> systems because bacteria experience extreme and rapidly changing conditions. A bacterial <span class="hlt">ori</span> must rapidly receive and process much information in “real-time” and not just in “cell cycle time.” This redefinition of bacterial <span class="hlt">oris</span> as centralized information processors makes at least two important predictions: First that bacterial <span class="hlt">oris</span> use many and yet to be discovered control mechanisms and second that evolutionarily distinct bacteria will use many very distinct control mechanisms. We review recent literature that supports both predictions. We will highlight three key examples and describe how negative-feedback, phospho-relay, and chromosome-partitioning systems act to regulate chromosome replication. We also suggest future studies and discuss using replication proteins as novel antibiotic targets. PMID:26136739</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li class="active"><span>12</span></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_12 --> <div id="page_13" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li class="active"><span>13</span></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="241"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26136739','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26136739"><span id="translatedtitle">Redefining bacterial origins of replication as centralized information processors.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Marczynski, Gregory T; Rolain, Thomas; Taylor, James A</p> <p>2015-01-01</p> <p>In this review we stress the differences between eukaryotes and bacteria with respect to their different cell cycles, replication mechanisms and genome organizations. One of the most basic and underappreciated differences is that a bacterial chromosome uses only one <span class="hlt">ori</span> while eukaryotic chromosome uses multiple <span class="hlt">oris</span>. Consequently, eukaryotic <span class="hlt">oris</span> work redundantly in a cell cycle divided into separate phases: First inactive replication proteins assemble on eukaryotic <span class="hlt">oris</span>, and then they await conditions (in the separate "S-phase") that activate only the <span class="hlt">ori</span>-bound and pre-assembled replication proteins. S-phase activation (without re-assembly) ensures that a eukaryotic <span class="hlt">ori</span> "fires" (starts replication) only once and that each chromosome consistently duplicates only once per cell cycle. This precise chromosome duplication does not require precise multiple <span class="hlt">ori</span> firing in S-phase. A eukaryotic <span class="hlt">ori</span> can fire early, late or not at all. The single bacterial <span class="hlt">ori</span> has no such margin for error and a comparable imprecision is lethal. Single <span class="hlt">ori</span> usage is not more primitive; it is a totally different strategy that distinguishes bacteria. We further argue that strong evolutionary pressures created more sophisticated single <span class="hlt">ori</span> systems because bacteria experience extreme and rapidly changing conditions. A bacterial <span class="hlt">ori</span> must rapidly receive and process much information in "real-time" and not just in "cell cycle time." This redefinition of bacterial <span class="hlt">oris</span> as centralized information processors makes at least two important predictions: First that bacterial <span class="hlt">oris</span> use many and yet to be discovered control mechanisms and second that evolutionarily distinct bacteria will use many very distinct control mechanisms. We review recent literature that supports both predictions. We will highlight three key examples and describe how negative-feedback, phospho-relay, and chromosome-partitioning systems act to regulate chromosome replication. We also suggest future studies and discuss using replication proteins as novel antibiotic targets. PMID:26136739</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/11288935','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/11288935"><span id="translatedtitle">Obsessive relational intrusion: incidence, perceived severity, and coping.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cupach, W R; Spitzberg, B H</p> <p>2000-01-01</p> <p>Two studies investigated the phenomenon of obsessive relational intrusion (<span class="hlt">ORI</span>), defined as repeated and unwanted pursuit and invasion of one's sense of physical or symbolic privacy by another person, either stranger or acquaintance, who desires and/or presumes an intimate relationship. In Study 1, we sought to identify the incidence of a broad range of relationally intrusive behaviors, to identify the coping responses employed by victims of <span class="hlt">ORI</span>, and to assess the associations between coping responses and <span class="hlt">ORI</span> behaviors. Study 2 assessed the perceived degree of severity of <span class="hlt">ORI</span> behaviors. Results revealed that each of 63 <span class="hlt">ORI</span> behaviors was experienced by 3-78% of respondents in three different samples. Factor analysis revealed four types of <span class="hlt">ORI</span> behavior: pursuit, violation, threat, and hyper-intimacy. Responses for coping with <span class="hlt">ORI</span> consisted of interaction, protection, retaliation, and evasion. Virtually all intrusive behaviors were perceived to be annoying. Some types of <span class="hlt">ORI</span> behaviors were perceived to be relatively more threatening, upsetting and privacy-invading than others. Although sex differences were not observed for the incidence of <span class="hlt">ORI</span> or coping, women consistently perceived <span class="hlt">ORI</span> behaviors to be more annoying, upsetting, threatening, and privacy-invading than did men. PMID:11288935</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3166829','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3166829"><span id="translatedtitle">Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Cayrou, Christelle; Coulombe, Philippe; Vigneron, Alice; Stanojcic, Slavica; Ganier, Olivier; Peiffer, Isabelle; Rivals, Eric; Puy, Aurore; Laurent-Chabalier, Sabine; Desprat, Romain; Méchali, Marcel</p> <p>2011-01-01</p> <p>In metazoans, thousands of DNA replication origins (<span class="hlt">Oris</span>) are activated at each cell cycle. Their genomic organization and their genetic nature remain elusive. Here, we characterized <span class="hlt">Oris</span> by nascent strand (NS) purification and a genome-wide analysis in Drosophila and mouse cells. We show that in both species most CpG islands (CGI) contain <span class="hlt">Oris</span>, although methylation is nearly absent in Drosophila, indicating that this epigenetic mark is not crucial for defining the activated origin. Initiation of DNA synthesis starts at the borders of CGI, resulting in a striking bimodal distribution of NS, suggestive of a dual initiation event. <span class="hlt">Oris</span> contain a unique nucleotide skew around NS peaks, characterized by G/T and C/A overrepresentation at the 5′ and 3′ of <span class="hlt">Ori</span> sites, respectively. Repeated GC-rich elements were detected, which are good predictors of <span class="hlt">Oris</span>, suggesting that common sequence features are part of metazoan <span class="hlt">Oris</span>. In the heterochromatic chromosome 4 of Drosophila, <span class="hlt">Oris</span> correlated with HP1 binding sites. At the chromosome level, regions rich in <span class="hlt">Oris</span> are early replicating, whereas <span class="hlt">Ori</span>-poor regions are late replicating. The genome-wide analysis was coupled with a DNA combing analysis to unravel the organization of <span class="hlt">Oris</span>. The results indicate that <span class="hlt">Oris</span> are in a large excess, but their activation does not occur at random. They are organized in groups of site-specific but flexible origins that define replicons, where a single origin is activated in each replicon. This organization provides both site specificity and <span class="hlt">Ori</span> firing flexibility in each replicon, allowing possible adaptation to environmental cues and cell fates. PMID:21750104</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19850005159','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19850005159"><span id="translatedtitle">Modulation of the cytosolic androgen receptor in striated muscle by sex steroids</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Rance, N. E.; Max, S. E.</p> <p>1982-01-01</p> <p>The influence of orchiectomy (GDX) and steroid administration on the level of the cytosolic androgen receptor in the rat <span class="hlt">levator</span> ani muscle and in rat skeletal muscles (tibialis anterior and extensor digitorum longus) was studied. Androgen receptor binding to muscle cytosol was measured using H-3 methyltrienolone (R1881) as ligand, 100 fold molar excess unlabeled R1881 to assess nonspecific binding, and 500 fold molar excess of triamcinolone acetonide to prevent binding to glucocorticoid and progestin receptors. Results demonstrate that modification of the levels of sex steroids can alter the content of androgen receptors of rat striated muscle. Data suggest that: (1) cytosolic androgen receptor levels increase after orchiectomy in both <span class="hlt">levator</span> ani muscle and skeletal muscle; (2) the acute increase in receptor levels is blocked by an inhibitor of protein synthesis; and (3) administration of estradiol-17 beta to castrated animals increases receptor binding in <span class="hlt">levator</span> ani muscle but not in skeletal muscle.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23879454','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23879454"><span id="translatedtitle">Complex of the herpes simplex virus type 1 origin binding protein UL9 with DNA as a platform for the design of a new type of antiviral drugs.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bazhulina, N P; Surovaya, A N; Gursky, Y G; Andronova, V L; Moiseeva, E D; Nikitin, Capital A Cyrillic M; Golovkin, M V; Galegov, G ?; Grokhovsky, S L; Gursky, G V</p> <p>2014-01-01</p> <p>The herpes simplex virus type 1 origin-binding protein, OBP, is a DNA helicase encoded by the UL9 gene. The protein binds in a sequence-specific manner to the viral origins of replication, two <span class="hlt">OriS</span> sites and one <span class="hlt">Ori</span>L site. In order to search for efficient inhibitors of the OBP activity, we have obtained a recombinant origin-binding protein expressed in Escherichia coli cells. The UL9 gene has been amplified by PCR and inserted into a modified plasmid pET14 between NdeI and KpnI sites. The recombinant protein binds to Box I and Box II sequences and possesses helicase and ATPase activities. In the presence of ATP and viral protein ICP8 (single-strand DNA-binding protein), the initiator protein induces unwinding of the minimal <span class="hlt">OriS</span> duplex (?80?bp). The protein also binds to a single-stranded DNA (<span class="hlt">OriS</span>*) containing a stable Box I-Box III hairpin and an unstable AT-rich hairpin at the 3'-end. In the present work, new minor groove binding ligands have been synthesized which are capable to inhibit the development of virus-induced cytopathic effect in cultured Vero cells. Studies on binding of these compounds to DNA and synthetic oligonucleotides have been performed by fluorescence methods, gel mobility shift analysis and footprinting assays. Footprinting studies have revealed that Pt-bis-netropsin and related molecules exhibit preferences for binding to the AT-spacer in <span class="hlt">OriS</span>. The drugs stabilize structure of the AT-rich region and inhibit the fluctuation opening of AT-base pairs which is a prerequisite to unwinding of DNA by OBP. Kinetics of ATP-dependent unwinding of <span class="hlt">OriS</span> in the presence and absence of netropsin derivatives have been studied by measuring the efficiency of Forster resonance energy transfer (FRET) between fluorophores attached to 5'- and 3'- ends of an oligonucleotide in the minimal <span class="hlt">OriS</span> duplex. The results are consistent with the suggestion that OBP is the DNA Holiday junction (HJ) binding helicase. The protein induces conformation changes (bending and partial melting) of <span class="hlt">OriS</span> duplexes and stimulates HJ formation in the absence of ATP. The antiviral activity of bis-netropsins is coupled with their ability to inhibit the fluctuation opening of ?? base pairs in the ??+?? cluster and their capacity to stabilize the structure of the ??-rich hairpin in the single-stranded oligonucleotide corresponding to the upper chain in the minimal duplex <span class="hlt">OriS</span>. The antiviral activities of bis-netropsins in cell culture and their therapeutic effects on HSV1-infected laboratory animals have been studied. PMID:23879454</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/2592620','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/2592620"><span id="translatedtitle">Motor innervation of respiratory muscles and an opercular display muscle in Siamese fighting fish Betta splendens.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gorlick, D L</p> <p>1989-12-15</p> <p>Horseradish peroxidase was used to identify motor neurons projecting to the adductor mandibulae, <span class="hlt">levator</span> hyomandibulae, <span class="hlt">levator</span> operculi, adductor operculi, and dilator operculi muscles in Siamese fighting fish, Betta splendens. These muscles participate in the production of respiratory and feeding movements in teleost fishes. The dilator operculi is also the effector muscle for gill-cover erection behavior that is part of Betta's aggressive display. The motor innervation of these muscles in Betta was compared to that previously described for carp. Motor neurons of the adductor mandibulae, <span class="hlt">levator</span> hyomandibulae, and dilator operculi are located in the trigeminal motor nucleus, and motor neurons of the adductor operculi and <span class="hlt">levator</span> operculi are located in the facial motor nucleus in Betta and in carp. The trigeminal motor nucleus in both species is divided into rostral and caudal subnuclei. However, there are substantial differences in the organization of the subnuclei, and in the distribution of motor neurons within them. In Betta, the rostral trigeminal subnucleus consists of a single part but the caudal subnucleus is divided into two parts. Motor neurons for the dilator operculi and <span class="hlt">levator</span> hyomandibulae muscles are located in the lateral part of the caudal subnucleus; the medial part of the caudal subnucleus contains only dilator operculi motor neurons. The single caudal subnucleus in carp is located laterally, and contains motor neurons of both the dilator operculi and <span class="hlt">levator</span> hyomandibulae muscles. Differences in the organization of the trigeminal motor nucleus may relate to the use of the dilator operculi muscle for aggressive display behavior by perciform fishes such as Betta but not by cypriniform fishes such as carp. Five species of perciform fishes that perform gill-cover erection behavior had a Betta-like pattern of organization of the caudal trigeminal nucleus and a similar distribution of dilator operculi motor neurons. Goldfish, which like carp are cypriniform fish and do not display, had a carp-like trigeminal organization and dilator operculi motor neuron distribution. PMID:2592620</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3885353','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3885353"><span id="translatedtitle">Physiological and Anatomical Evidence for an Inhibitory Trigemino-Oculomotor Pathway in the Cat</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>May, Paul J.; Vidal, Pierre-Paul; Baker, Harriet; Baker, Robert</p> <p>2013-01-01</p> <p>During blink down-phase, the <span class="hlt">levator</span> palpebrae superioris (<span class="hlt">levator</span>) muscle is inactivated, allowing the orbicularis oculi muscle to act. For trigeminal reflex blinks, the excitatory connections from trigeminal sensory nuclei to the facial nucleus have been described, but the pathway whereby the <span class="hlt">levator</span> is turned off have not. We examined this question by use of both physiological and anatomical approaches in the cat. Intracellular records from antidromically activated <span class="hlt">levator</span> motoneurons revealed that periorbital electrical stimulation produced bilateral, long latency inhibitory postsynaptic potentials (IPSPs). Central electrical stimulation of the principal trigeminal nucleus produced shorter latency IPSPs. Intracellular staining revealed that these motoneurons reside in the caudal central subdivision and have 10 or more poorly branched dendrites, which extend bilaterally into the surrounding supraoculomotor area. Axons penetrated in this region could be activated from periorbital and central electrodes. Neurons labeled from tracer injections into the caudal oculomotor complex were distributed in a crescent-shaped band that lined the ventral and rostral aspects of the pontine trigeminal sensory nucleus. Double-label immunohisto-chemical procedures demonstrated that these cells were not tyrosine hydroxylase-positive cells in the Kölliker-Fuse area. Instead, supraorbital nerve afferents displayed a similar crescent-shaped distribution, suggesting they drive these trigemino-oculomotor neurons. Anterograde labeling of the trigemino-oculomotor projection indicates that it terminates bilaterally, in and above the caudal central subdivision. These results characterize a trigemino-oculomotor pathway that inhibits <span class="hlt">levator</span> palpebrae motoneurons in response to blink-producing periorbital stimuli. The bilateral distributions of trigemino-oculomotor afferents, <span class="hlt">levator</span> motoneurons, and their dendrites supply a morphological basis for conjugate lid movements. PMID:22237697</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27007137','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27007137"><span id="translatedtitle">Multiple Lytic Origins of Replication Are Required for Optimal Gammaherpesvirus Fitness In Vitro and In Vivo.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sattler, Christine; Steer, Beatrix; Adler, Heiko</p> <p>2016-03-01</p> <p>An unresolved question in herpesvirus biology is why some herpesviruses contain more than one lytic origin of replication (<span class="hlt">ori</span>Lyt). Using murine gammaherpesvirus 68 (MHV-68) as model virus containing two <span class="hlt">ori</span>Lyts, we demonstrate that loss of either of the two <span class="hlt">ori</span>Lyts was well tolerated in some situations but not in others both in vitro and in vivo. This was related to the cell type, the organ or the route of inoculation. Depending on the cell type, different cellular proteins, for example Hexim1 and Rbbp4, were found to be associated with <span class="hlt">ori</span>Lyt DNA. Overexpression or downregulation of these proteins differentially affected the growth of mutants lacking either the left or the right <span class="hlt">ori</span>Lyt. Thus, multiple <span class="hlt">ori</span>Lyts are required to ensure optimal fitness in different cell types and tissues. PMID:27007137</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26220967&dopt=AbstractPlus','TOXNETTOXLINE'); return false;" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26220967&dopt=AbstractPlus"><span id="translatedtitle">Molecular Dissection of the Essential Features of the Origin of Replication of the Second Vibrio cholerae Chromosome.</span></a></p> <p><a target="_blank" href="http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?TOXLINE">TOXLINE Toxicology Bibliographic Information</a></p> <p>Gerding MA; Chao MC; Davis BM; Waldor MK</p> <p>2015-01-01</p> <p>IMPORTANCE: The genome of the enteric pathogen Vibrio cholerae consists of two chromosomes. While the chromosome I replication origin and its cognate replication initiator protein resemble those of Escherichia coli, the factors responsible for chromosome II replication initiation display no similarity to any other known initiation systems. Here, to enhance our understanding of how this DNA sequence, <span class="hlt">ori</span>CII, and its initiator protein, RctB, function, we used both targeted mutagenesis and a new random-mutagenesis approach (<span class="hlt">Ori</span>Seq) to finely map the <span class="hlt">ori</span>CII structural features and sequences required for RctB-mediated DNA replication. Collectively, our findings reveal the extraordinary evolutionary honing of the architecture and motifs that constitute <span class="hlt">ori</span>CII and reveal a new role for methylation in <span class="hlt">ori</span>CII-based replication. Finally, our findings suggest that the <span class="hlt">Ori</span>Seq approach is likely to be widely applicable for defining critical bases in cis-acting sequences.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23016736','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23016736"><span id="translatedtitle">New light through old windows: nurses, colonists and indigenous survival.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>McKillop, Ann; Sheridan, Nicolette; Rowe, Deborah</p> <p>2013-09-01</p> <p>The aim of this study was to explore the influences, processes and environments that shaped the practice of European nurses for indigenous New Zealand (NZ) Mā<span class="hlt">ori</span> communities who were being overwhelmed by introduced infectious diseases. Historical data were accessed from multiple archival sources and analysed through the lens of colonial theory. Through their work early last century, NZ nurses actively gained professional status and territory through their work with Mā<span class="hlt">ori</span>. By living and working alongside Mā<span class="hlt">ori</span>, they learned to practise in new ways that influenced Mā<span class="hlt">ori</span> health. By developing a new role in new professional territory, nurses extended their practice to include health promotion as well as disease prevention. Mā<span class="hlt">ori</span> survival from epidemics improved, and the population grew over that period. For Mā<span class="hlt">ori</span>, however, Eurocentric care alleviated their immediate health problems, but the detrimental impact of the mechanisms of colonisation overall has continued to the present day. PMID:23016736</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=395404','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=395404"><span id="translatedtitle">Parental strand recognition of the DNA replication origin by the outer membrane in Escherichia coli.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Herrick, J; Kern, R; Guha, S; Landoulsi, A; Fayet, O; Malki, A; Kohiyama, M</p> <p>1994-01-01</p> <p>The outer membrane of Escherichia coli binds the origin of DNA replication (<span class="hlt">ori</span>C) only when it is hemimethylated. We report here the results of a footprinting analysis with the outer membrane which demonstrate that its interaction with <span class="hlt">ori</span>C occurs mainly at the left moiety of the minimal <span class="hlt">ori</span>C, where 10 out of 11 Dam methylation sites are concentrated. Two regions, flanking the Integration Host Factor (IHF) sites, are preferentially recognized at the minimum membrane concentration at which <span class="hlt">ori</span>C plasmid replication is inhibited in vitro. We have identified the putative proteins involved in hemimethylated <span class="hlt">ori</span>C binding and cloned one of the corresponding genes (hobH). The purified LacZ-HobH fusion protein specifically binds <span class="hlt">ori</span>C DNA at the same preferential sites as the membrane. A mutant of the hobH gene reveals partial asynchronous initiation of DNA replication. Images PMID:7925311</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4133239','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4133239"><span id="translatedtitle">Oridonin Attenuates A?142-Induced Neuroinflammation and Inhibits NF-?B Pathway</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Yu, Linjie; Jin, Jiali; Qian, Lai; Zhao, Hui; Xu, Yun; Zhu, Xiaolei</p> <p>2014-01-01</p> <p>Neuroinflammation induced by beta-amyloid (A?) plays a critical role in the pathogenesis of Alzheimers disease (AD), and inhibiting A?-induced neuroinflammation serves as a potential strategy for the treatment of AD. Oridonin (<span class="hlt">Ori</span>), a compound of Rabdosia rubescens, has been shown to exert anti-inflammatory effects. In this study, we demonstrated that <span class="hlt">Ori</span> inhibited glial activation and decreased the release of inflammatory cytokines in the hippocampus of A?142-induced AD mice. In addition, <span class="hlt">Ori</span> inhibited the NF-?B pathway and A?142-induced apoptosis. Furthermore, <span class="hlt">Ori</span> could attenuate memory deficits in A?142-induced AD mice. In conclusion, our study demonstrated that <span class="hlt">Ori</span> inhibited the neuroinflammation and attenuated memory deficits induced by A?142, suggesting that <span class="hlt">Ori</span> might be a promising candidate for AD treatment. PMID:25121593</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25121593','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25121593"><span id="translatedtitle">Oridonin attenuates A?1-42-induced neuroinflammation and inhibits NF-?B pathway.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wang, Sulei; Yang, Hui; Yu, Linjie; Jin, Jiali; Qian, Lai; Zhao, Hui; Xu, Yun; Zhu, Xiaolei</p> <p>2014-01-01</p> <p>Neuroinflammation induced by beta-amyloid (A?) plays a critical role in the pathogenesis of Alzheimer's disease (AD), and inhibiting A?-induced neuroinflammation serves as a potential strategy for the treatment of AD. Oridonin (<span class="hlt">Ori</span>), a compound of Rabdosia rubescens, has been shown to exert anti-inflammatory effects. In this study, we demonstrated that <span class="hlt">Ori</span> inhibited glial activation and decreased the release of inflammatory cytokines in the hippocampus of A?1-42-induced AD mice. In addition, <span class="hlt">Ori</span> inhibited the NF-?B pathway and A?1-42-induced apoptosis. Furthermore, <span class="hlt">Ori</span> could attenuate memory deficits in A?1-42-induced AD mice. In conclusion, our study demonstrated that <span class="hlt">Ori</span> inhibited the neuroinflammation and attenuated memory deficits induced by A?1-42, suggesting that <span class="hlt">Ori</span> might be a promising candidate for AD treatment. PMID:25121593</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4805163','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4805163"><span id="translatedtitle">Multiple Lytic Origins of Replication Are Required for Optimal Gammaherpesvirus Fitness In Vitro and In Vivo</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Sattler, Christine; Steer, Beatrix; Adler, Heiko</p> <p>2016-01-01</p> <p>An unresolved question in herpesvirus biology is why some herpesviruses contain more than one lytic origin of replication (<span class="hlt">ori</span>Lyt). Using murine gammaherpesvirus 68 (MHV-68) as model virus containing two <span class="hlt">ori</span>Lyts, we demonstrate that loss of either of the two <span class="hlt">ori</span>Lyts was well tolerated in some situations but not in others both in vitro and in vivo. This was related to the cell type, the organ or the route of inoculation. Depending on the cell type, different cellular proteins, for example Hexim1 and Rbbp4, were found to be associated with <span class="hlt">ori</span>Lyt DNA. Overexpression or downregulation of these proteins differentially affected the growth of mutants lacking either the left or the right <span class="hlt">ori</span>Lyt. Thus, multiple <span class="hlt">ori</span>Lyts are required to ensure optimal fitness in different cell types and tissues. PMID:27007137</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-508.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-508.pdf"><span id="translatedtitle">42 CFR 93.508 - Filing, forms, and service.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative... nondocumentary materials such as videotapes, computer disks, or physical evidence. This provision does not...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-508.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-508.pdf"><span id="translatedtitle">42 CFR 93.508 - Filing, forms, and service.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative... nondocumentary materials such as videotapes, computer disks, or physical evidence. This provision does not...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25477864','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25477864"><span id="translatedtitle">Sequence analysis of origins of replication in the Saccharomyces cerevisiae genomes.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Li, Wen-Chao; Zhong, Zhe-Jin; Zhu, Pan-Pan; Deng, En-Ze; Ding, Hui; Chen, Wei; Lin, Hao</p> <p>2014-01-01</p> <p>DNA replication is a highly precise process that is initiated from origins of replication (<span class="hlt">ORIs</span>) and is regulated by a set of regulatory proteins. The mining of DNA sequence information will be not only beneficial for understanding the regulatory mechanism of replication initiation but also for accurately identifying <span class="hlt">ORIs</span>. In this study, the GC profile and GC skew were calculated to analyze the compositional bias in the Saccharomyces cerevisiae genome. We found that the GC profile in the region of <span class="hlt">ORIs</span> is significantly lower than that in the flanking regions. By calculating the information redundancy, an estimation of the correlation of nucleotides, we found that the intensity of adjoining correlation in <span class="hlt">ORIs</span> is dramatically higher than that in flanking regions. Furthermore, the relationships between <span class="hlt">ORIs</span> and nucleosomes as well as transcription start sites were investigated. Results showed that <span class="hlt">ORIs</span> are usually not occupied by nucleosomes. Finally, we calculated the distribution of <span class="hlt">ORIs</span> in yeast chromosomes and found that most <span class="hlt">ORIs</span> are in transcription terminal regions. We hope that these results will contribute to the identification of <span class="hlt">ORIs</span> and the study of DNA replication mechanisms. PMID:25477864</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title42-vol1/pdf/CFR-2014-title42-vol1-sec93-512.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title42-vol1/pdf/CFR-2014-title42-vol1-sec93-512.pdf"><span id="translatedtitle">42 CFR 93.512 - Discovery.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative Actions...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title42-vol1/pdf/CFR-2012-title42-vol1-sec93-512.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title42-vol1/pdf/CFR-2012-title42-vol1-sec93-512.pdf"><span id="translatedtitle">42 CFR 93.512 - Discovery.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative Actions...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title42-vol1/pdf/CFR-2013-title42-vol1-sec93-512.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title42-vol1/pdf/CFR-2013-title42-vol1-sec93-512.pdf"><span id="translatedtitle">42 CFR 93.512 - Discovery.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>... STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative Actions...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li class="active"><span>13</span></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_13 --> <div id="page_14" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li class="active"><span>14</span></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="261"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-512.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-512.pdf"><span id="translatedtitle">42 CFR 93.512 - Discovery.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative Actions...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21042934','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21042934"><span id="translatedtitle">Enhanced production of single copy backbone-free transgenic plants in multiple crop species using binary vectors with a pRi replication origin in Agrobacterium tumefaciens.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ye, Xudong; Williams, Edward J; Shen, Junjiang; Johnson, Susan; Lowe, Brenda; Radke, Sharon; Strickland, Steve; Esser, James A; Petersen, Michael W; Gilbertson, Larry A</p> <p>2011-08-01</p> <p>Single transgene copy, vector backbone-free transgenic crop plants are highly desired for functional genomics and many biotechnological applications. We demonstrate that binary vectors that use a replication origin derived from the Ri plasmid of Agrobacterium rhizogenes (<span class="hlt">ori</span>Ri) increase the frequency of single copy, backbone-free transgenic plants in Agrobacterium tumefaciens mediated transformation of soybean, canola, and corn, compared to RK2-derived binary vectors (RK2 <span class="hlt">ori</span>V). In large scale soybean transformation experiments, the frequency of single copy, backbone-free transgenic plants was nearly doubled in two versions of the <span class="hlt">ori</span>Ri vectors compared to the RK2 <span class="hlt">ori</span>V control vector. In canola transformation experiments, the <span class="hlt">ori</span>Ri vector produced more single copy, backbone-free transgenic plants than did the RK2 <span class="hlt">ori</span>V vector. In corn transformation experiments, the frequency of single copy backbone-free transgenic plants was also significantly increased when using the <span class="hlt">ori</span>Ri vector, although the transformation frequency dropped. These results, derived from transformation experiments using three crops, indicate the advantage of <span class="hlt">ori</span>Ri vectors over RK2 <span class="hlt">ori</span>V binary vectors for the production of single copy, backbone-free transgenic plants using Agrobacterium-mediated transformation. PMID:21042934</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=110677','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=110677"><span id="translatedtitle">Transcription-Dependent DNA Transactions in the Mitochondrial Genome of a Yeast Hypersuppressive Petite Mutant</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Van Dyck, Eric; Clayton, David A.</p> <p>1998-01-01</p> <p>Mitochondrial DNA (mtDNA) of Saccharomyces cerevisiae contains highly conserved sequences, called rep/<span class="hlt">ori</span>, that are associated with several aspects of its metabolism. These rep/<span class="hlt">ori</span> sequences confer the transmission advantage exhibited by a class of deletion mutants called hypersuppressive petite mutants. In addition, because they share features with the mitochondrial leading-strand DNA replication origin of mammals, rep/<span class="hlt">ori</span> sequences have also been proposed to participate in mtDNA replication initiation. Like the mammalian origins, where transcription is used as a priming mechanism for DNA synthesis, yeast rep/<span class="hlt">ori</span> sequences contain an active promoter. Although transcription is required for maintenance of wild-type mtDNA in yeast, the role of the rep/<span class="hlt">ori</span> promoter as a cis-acting element involved in the replication of wild-type mtDNA is unclear, since mitochondrial deletion mutants need neither transcription nor a rep/<span class="hlt">ori</span> sequence to maintain their genome. Similarly, transcription from the rep/<span class="hlt">ori</span> promoter does not seem to be necessary for biased inheritance of mtDNA. As a step to elucidate the function of the rep/<span class="hlt">ori</span> promoter, we have attempted to detect transcription-dependent DNA transactions in the mtDNA of a hypersuppressive petite mutant. We have examined the mtDNA of the well-characterized petite mutant a-1/1R/Z1, whose repeat unit shelters the rep/<span class="hlt">ori</span> sequence <span class="hlt">ori</span>1, in strains carrying either wild-type or null alleles of the nuclear genes encoding the mitochondrial transcription apparatus. Complex DNA transactions were detected that take place around GC-cluster C, an evolutionarily conserved GC-rich sequence block immediately downstream from the rep/<span class="hlt">ori</span> promoter. These transactions are strictly dependent upon mitochondrial transcription. PMID:9566917</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=60432&keyword=growth+AND+hormone&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=45836425&CFTOKEN=11464785','EPA-EIMS'); return false;" href="http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=60432&keyword=growth+AND+hormone&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=45836425&CFTOKEN=11464785"><span id="translatedtitle">COMBINED EFFECTS OF ANTIANDROGENIC PESTICIDESVINCLOZOLIN AND PROCYMIDONE ON ANDROGEN-DEPENDENT TISSUE IN THE HERSHBERGER ASSAY USING SPRAGUE-DAWLEY RATS</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>Vinclozolin(V) and procymidone(P) are antiandrogens which block <br>testosterone (T) and dihydrotestosterone (DHT) action by competing with <br>these steroid hormones for the androgen receptor. These pesticides alone <br>are known to block T-induced ventral prostate and <span class="hlt">levator</span> ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=215117','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=215117"><span id="translatedtitle">Contractile properties of single permeabilized muscle fibers from congenital cleft palates and normal palates of Spanish goats</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>A goat model in which cleft palate is induced by the plant alkaloid, anabasine was used to determine muscle fiber integrity of the <span class="hlt">levator</span> veli palatine muscle. It was determined that the muscle fibers of the cleft palate-induced goats were primarily of the type 2 (fast fibers) which fatigue easil...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=215120','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=215120"><span id="translatedtitle">Contraction-induced injury to single permeabilized muscle fibers from normal and congenitally-clefted goat palates</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>A goat model in which cleft palate is induced by the plant alkaloid, anabasine was used to determine muscle fiber integrity of the <span class="hlt">levator</span> veli palatine (LVP) muscle. It was determined that muscle fiber type, size, and sensitivity to contraction-induced injury was different between cleft palate ind...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=emg&pg=5&id=EJ117746','ERIC'); return false;" href="http://eric.ed.gov/?q=emg&pg=5&id=EJ117746"><span id="translatedtitle">Palatal Activity in Voicing Distinctions: A Simultaneous Fiberoptic and Electromyographic Study</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Bell-Berti, Fredericka; Hirose, Hajime</p> <p>1975-01-01</p> <p>A study of electromyographic (EMG) activity and palatal movement is reported. Motion pictures were taken of the nasal surface of the soft palate and EMG recordings from the <span class="hlt">levator</span> palatini muscle were obtained. Both were analyzed for the relationship of velar height to EMG strength and time. (SC)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=230923','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=230923"><span id="translatedtitle">Effect of cleft palate repair on the susceptibility to contraction-induced injury of single permeabilized muscle fibers from congenitally-clefted goat palates.</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>Despite cleft palate repair, velopharyngeal competence is not achieved in ~ 15% of patients, often necessitating secondary surgical correction. Velopharyngeal competence postrepair may require the conversion of <span class="hlt">levator</span> veli palatini muscle fibers from injury-susceptible type 2 fibers to injury-resi...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23177757','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23177757"><span id="translatedtitle">[A case of symptomatic sinus dysfunction described in oculopharyngeal muscular dystrophy. Fortuitous association or syndrome?].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Belmihoub-Salmi, S</p> <p>2016-02-01</p> <p>Oculopharyngeal muscular dystrophy is a rare genetic disease manifesting after 45years old, affecting the <span class="hlt">levator</span> muscles of eyelids and muscles of swallowing. We report the first case of a patient of 73years old suffering from an oculopharyngeal muscular dystrophy hospitalized for syncope, a complication of severe sinus dysfunction, requiring the implantation of a pacemaker. PMID:23177757</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=226591','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=226591"><span id="translatedtitle">The Effect of Cleft Palate Repair on Contractile Properties of Single Permeabilized Muscle Fibers From Congenitally Cleft Goats Palates</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>A cleft palate goat model was used to study the contractile properties of the <span class="hlt">levator</span> veli palatini (LVP) muscle which is responsible for the movement of the soft palate. In 15-25% of patients that undergo palatoplasty, residual velopharyngeal insufficiency (VPI) remains a problem and often require...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=19760050464&hterms=Fink&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3DT.%2BFink','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=19760050464&hterms=Fink&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D20%26Ntt%3DT.%2BFink"><span id="translatedtitle">A lower limit on the surface C-12/C-13 ratio in Alpha Orionis</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Gautier, T. N., III; Fink, U.; Larson, H. P.; Thompson, R. I.</p> <p>1976-01-01</p> <p>The second overtone CO bands near 1.6 microns were analyzed in Alpha <span class="hlt">Ori</span> using synthetic spectra. No firm identification of (C-13)O was made, which allowed a lower limit of 20 to be set on the C-12/C-13 ratio. A rather low microturbulent velocity of 2 km/s was found to match the spectrum of Alpha <span class="hlt">Ori</span> best.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4009838','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4009838"><span id="translatedtitle">Recent Advances in the Identification of Replication Origins Based on the Z-curve Method</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Gao, Feng</p> <p>2014-01-01</p> <p>Precise DNA replication is critical for the maintenance of genetic integrity in all organisms. In all three domains of life, DNA replication starts at a specialized locus, termed as the replication origin, <span class="hlt">ori</span>C or <span class="hlt">ORI</span>, and its identification is vital to understanding the complex replication process. In bacteria and eukaryotes, replication initiates from single and multiple origins, respectively, while archaea can adopt either of the two modes. The Z-curve method has been successfully used to identify replication origins in genomes of various species, including multiple <span class="hlt">ori</span>Cs in some archaea. Based on the Z-curve method and comparative genomics analysis, we have developed a web-based system, <span class="hlt">Ori</span>-Finder, for finding <span class="hlt">ori</span>Cs in bacterial genomes with high accuracy. Predicted <span class="hlt">ori</span>C regions in bacterial genomes are organized into an online database, DoriC. Recently, archaeal <span class="hlt">ori</span>C regions identified by both in vivo and in silico methods have also been included in the database. Here, we summarize the recent advances of in silico prediction of <span class="hlt">ori</span>Cs in bacterial and archaeal genomes using the Z-curve based method. PMID:24822028</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3936714','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3936714"><span id="translatedtitle">Multiple replication origins with diverse control mechanisms in Haloarcula hispanica</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Wu, Zhenfang; Liu, Jingfang; Yang, Haibo; Liu, Hailong; Xiang, Hua</p> <p>2014-01-01</p> <p>The use of multiple replication origins in archaea is not well understood. In particular, little is known about their specific control mechanisms. Here, we investigated the active replication origins in the three replicons of a halophilic archaeon, Haloarcula hispanica, by extensive gene deletion, DNA mutation and genome-wide marker frequency analyses. We revealed that individual origins are specifically dependent on their co-located cdc6 genes, and a single active origin/cdc6 pairing is essential and sufficient for each replicon. Notably, we demonstrated that the activities of <span class="hlt">ori</span>C1 and <span class="hlt">ori</span>C2, the two origins on the main chromosome, are differently controlled. A G-rich inverted repeat located in the internal region between the two inverted origin recognition boxes (ORBs) plays as an enhancer for <span class="hlt">ori</span>C1, whereas the replication initiation at <span class="hlt">ori</span>C2 is negatively regulated by an ORB-rich region located downstream of <span class="hlt">ori</span>C2-cdc6E, likely via Cdc6E-titrating. The <span class="hlt">ori</span>C2 placed on a plasmid is incompatible with the wild-type (but not the Δ<span class="hlt">ori</span>C2) host strain, further indicating that strict control of the <span class="hlt">ori</span>C2 activity is important for the cell. This is the first report revealing diverse control mechanisms of origins in haloarchaea, which has provided novel insights into the use and coordination of multiple replication origins in the domain of Archaea. PMID:24271389</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=19740049343&hterms=boo&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Dboo','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=19740049343&hterms=boo&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Dboo"><span id="translatedtitle">Four stellar-diameter measurements by a new technique - Amplitude interferometry</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Currie, D. G.; Knapp, S. L.; Liewer, K. M.</p> <p>1974-01-01</p> <p>Diameters are reported for four late-type giant stars, alpha Boo, alpha <span class="hlt">Ori</span>, alpha Tau, and beta Peg. The diameters were obtained with a new kind of interferometer designed expressly to operate in the presence of atmospheric fluctuations. The new technique, called amplitude interferometry, is briefly described. The results include measurements of alpha <span class="hlt">Ori</span> at several wavelengths.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title42-vol1/pdf/CFR-2013-title42-vol1-sec93-316.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title42-vol1/pdf/CFR-2013-title42-vol1-sec93-316.pdf"><span id="translatedtitle">42 CFR 93.316 - Completing the research misconduct process.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>... <span class="hlt">ORI</span> in advance if the institution plans to close a case at the inquiry, investigation, or appeal stage... reached, or for any other reason, except the closing of a case at the inquiry stage on the basis that an... to <span class="hlt">ORI</span> under 93.315. (b) After consulting with the institution on its basis for closing a...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title42-vol1/pdf/CFR-2014-title42-vol1-sec93-316.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title42-vol1/pdf/CFR-2014-title42-vol1-sec93-316.pdf"><span id="translatedtitle">42 CFR 93.316 - Completing the research misconduct process.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... <span class="hlt">ORI</span> in advance if the institution plans to close a case at the inquiry, investigation, or appeal stage... reached, or for any other reason, except the closing of a case at the inquiry stage on the basis that an... to <span class="hlt">ORI</span> under 93.315. (b) After consulting with the institution on its basis for closing a...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24271389','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24271389"><span id="translatedtitle">Multiple replication origins with diverse control mechanisms in Haloarcula hispanica.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wu, Zhenfang; Liu, Jingfang; Yang, Haibo; Liu, Hailong; Xiang, Hua</p> <p>2014-02-01</p> <p>The use of multiple replication origins in archaea is not well understood. In particular, little is known about their specific control mechanisms. Here, we investigated the active replication origins in the three replicons of a halophilic archaeon, Haloarcula hispanica, by extensive gene deletion, DNA mutation and genome-wide marker frequency analyses. We revealed that individual origins are specifically dependent on their co-located cdc6 genes, and a single active origin/cdc6 pairing is essential and sufficient for each replicon. Notably, we demonstrated that the activities of <span class="hlt">ori</span>C1 and <span class="hlt">ori</span>C2, the two origins on the main chromosome, are differently controlled. A G-rich inverted repeat located in the internal region between the two inverted origin recognition boxes (ORBs) plays as an enhancer for <span class="hlt">ori</span>C1, whereas the replication initiation at <span class="hlt">ori</span>C2 is negatively regulated by an ORB-rich region located downstream of <span class="hlt">ori</span>C2-cdc6E, likely via Cdc6E-titrating. The <span class="hlt">ori</span>C2 placed on a plasmid is incompatible with the wild-type (but not the ?<span class="hlt">ori</span>C2) host strain, further indicating that strict control of the <span class="hlt">ori</span>C2 activity is important for the cell. This is the first report revealing diverse control mechanisms of origins in haloarchaea, which has provided novel insights into the use and coordination of multiple replication origins in the domain of Archaea. PMID:24271389</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=19790040588&hterms=THETA&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3DTHETA','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=19790040588&hterms=THETA&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3DTHETA"><span id="translatedtitle">Photographic observations of Theta-1 Orionis</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Feibelman, W. A.; Gull, T. R.</p> <p>1979-01-01</p> <p>Photographic observations of the eclipsing binary Theta-1 <span class="hlt">Ori</span> A suggest a secondary minimum near phase 0.64 of its 65.43233-day period. This minimum may be wavelength dependent. The star Theta-1 <span class="hlt">Ori</span> E is suspected of being variable.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25593457','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25593457"><span id="translatedtitle">Magnetic resonance imaging based rectal cancer classification: landmarks and technical standardization.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Alasari, Sami; Lim, Daero; Kim, Nam Kyu</p> <p>2015-01-14</p> <p>Rectal cancer classification is important to determine the preoperative chemoradiation therapy and to select appropriate surgical technique. We reviewed the Western and Japanese rectal cancer classification and we propose our new classification based of Magnetic resonance imaging (MRI). We determine the relation of the tumor to fixed parameters in MRI, which are peritoneal reflection and <span class="hlt">levator</span> ani muscle. Then, we classify the rectal cancer into four levels based on tumor distal margin and invasion to MRI parameters. We applied all three classifications to 60 retrospectively collected patients of different rectal cancer distance and we compared our classifications to the others. Based on each level we standardize our surgical approach. For stages?I-III, We found that level?I?where tumor distal margin is located above the peritoneal reflection and all of them were received low anterior resection (LAR) without chemoradiation. Level II where tumor distal margin is located from the peritoneal reflection and above the <span class="hlt">levator</span> ani insertion on the rectum. 90% of them were received LAR chemoradiation. Level III where tumor distal margin is located at the level of <span class="hlt">levator</span> ani insertion or invading any part of the <span class="hlt">levator</span> ani. 60% of them had ULAR + coloanal anastomosis chemoradiation. Level IV where the tumor distal margin is located below the <span class="hlt">levator</span> ani insertion; 77% were received APR chemoradiation. The overall kappa for all levels between surgeons and radiologist was 0.93 (95%CI: 0.87-0.99), which is indicating almost perfect agreement. We concluded that the management of rectal tumors differed among each tumor level and our new MRI based classification might facilitate the prediction of surgical and chemoradiation management with better communication among a multidisciplinary team comparing to other classifications. PMID:25593457</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25757664','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25757664"><span id="translatedtitle">A multi-compartment 3-D finite element model of rectocele and its interaction with cystocele.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Luo, Jiajia; Chen, Luyun; Fenner, Dee E; Ashton-Miller, James A; DeLancey, John O L</p> <p>2015-06-25</p> <p>We developed a subject-specific 3-D finite element model to understand the mechanics underlying formation of female pelvic organ prolapse, specifically a rectocele and its interaction with a cystocele. The model was created from MRI 3-D geometry of a healthy 45 year-old multiparous woman. It included anterior and posterior vaginal walls, <span class="hlt">levator</span> ani muscle, cardinal and uterosacral ligaments, anterior and posterior arcus tendineus fascia pelvis, arcus tendineus <span class="hlt">levator</span> ani, perineal body, perineal membrane and anal sphincter. Material properties were mostly from the literature. Tissue impairment was modeled as decreased tissue stiffness based on previous clinical studies. Model equations were solved using Abaqus v 6.11. The sensitivity of anterior and posterior vaginal wall geometry was calculated for different combinations tissue impairments under increasing intraabdominal pressure. Prolapse size was reported as pelvic organ prolapse quantification system (POP-Q) point at point Bp for rectocele and point Ba for cystocele. Results show that a rectocele resulted from impairments of the <span class="hlt">levator</span> ani and posterior compartment support. For 20% <span class="hlt">levator</span> and 85% posterior support impairments, simulated rectocele size (at POP-Q point: Bp) increased 0.29 mm/cm H2O without apical impairment and 0.36 mm/cm H2O with 60% apical impairment, as intraabdominal pressures increased from 0 to 150 cm H2O. Apical support impairment could result in the development of either a cystocele or rectocele. Simulated repair of posterior compartment support decreased rectocele but increased a preexisting cystocele. We conclude that development of rectocele and cystocele depend on the presence of anterior, posterior, <span class="hlt">levator</span> and/or or apical support impairments, as well as the interaction of the prolapse with the opposing compartment. PMID:25757664</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li class="active"><span>14</span></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_14 --> <div id="page_15" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li class="active"><span>15</span></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="281"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4790895','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4790895"><span id="translatedtitle">Oridonin Attenuates Synaptic Loss and Cognitive Deficits in an Aβ1–42-Induced Mouse Model of Alzheimer’s Disease</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Yang, Hui; Li, Chaosheng; Hui, Zhen; Xu, Yun; Zhu, Xiaolei</p> <p>2016-01-01</p> <p>Synaptic loss induced by beta-amyloid (Aβ) plays a critical role in the pathophysiology of Alzheimer’s disease (AD), but the mechanisms underlying this process remain unknown. In this study, we found that oridonin (<span class="hlt">Ori</span>) rescued synaptic loss induced by Aβ1–42 in vivo and in vitro and attenuated the alterations in dendritic structure and spine density observed in the hippocampus of AD mice. In addition, <span class="hlt">Ori</span> increased the expression of PSD-95 and synaptophysin and promoted mitochondrial activity in the synaptosomes of AD mice. <span class="hlt">Ori</span> also activated the BDNF/TrkB/CREB signaling pathway in the hippocampus of AD mice. Furthermore, in the Morris water maze test, <span class="hlt">Ori</span> reduced latency and searching distance and increased the number of platform crosses in AD mice. These data suggest that <span class="hlt">Ori</span> might prevent synaptic loss and improve behavioral symptoms in Aβ1–42-induced AD mice. PMID:26974541</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/19185062','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/19185062"><span id="translatedtitle">Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Xu, Yan; Xue, Yang; Wang, Ying; Feng, Dechun; Lin, Shuting; Xu, Lingyun</p> <p>2009-03-01</p> <p>Microglial activation has been implicated in many neurological disorders for its inflammatory and/or neurotrophic effects. In this study, we investigated the effects upon activated microglia of Oridonin (<span class="hlt">Ori</span>), an effective component isolated from Rabdosia rubescens. We pretreated rat primary microglia with or without <span class="hlt">Ori</span>, then stimulated with lipopolysaccharide (LPS). We found that <span class="hlt">Ori</span> pretreatment inhibited the release of proinflammatory mediators including nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6). Such suppressive effects were accompanied by inhibition of DNA binding activity of the critical transcription factor nuclear factor-kappa B (NF-kappaB). In addition, <span class="hlt">Ori</span> upregulated the production of the neurotrophic factor, nerve growth factor (NGF). Our findings suggest that <span class="hlt">Ori</span> may have anti-inflammatory and neuroregulatory effects through modulation of multiple functions of microglia. PMID:19185062</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/19302235','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/19302235"><span id="translatedtitle">Apoptosis inducing and differentiation enhancement effect of oridonin on the all-trans-retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gao, F; Tang, Q; Yang, P; Fang, Y; Li, W; Wu, Y</p> <p>2010-02-01</p> <p>We investigated the effects of oridonin (<span class="hlt">Ori</span>), a diterpenoid isolated from Rabdosia rubescens, on apoptosis and differentiation of all-trans-retinoic acid (ATRA)-sensitive (NB4) and ATRA-resistant (NB4-R1) cells. The results showed that reactive oxygen species initiates <span class="hlt">Ori</span>-induced apoptosis. In addition, we found that neither <span class="hlt">Ori</span> nor ATRA (10 nM) alone induced marked cell differentiation, while co-treatment of these two compounds can induce differentiation of NB4 and NB4-R1 cells which was accompanied by increased RARalpha, C/EBPepsilon or C/EBPbeta. This is the first report to show that RARalpha could be accumulated by <span class="hlt">Ori</span> which may be useful as a probe to investigate the mechanism of RARalpha catabolism. These results suggest that <span class="hlt">Ori</span> is a potential candidate for acute promyelocytic leukemia cancer therapy. PMID:19302235</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4551981','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4551981"><span id="translatedtitle">Molecular Dissection of the Essential Features of the Origin of Replication of the Second Vibrio cholerae Chromosome</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Gerding, Matthew A.; Chao, Michael C.; Davis, Brigid M.</p> <p>2015-01-01</p> <p>ABSTRACT Vibrionaceae family members are interesting models for studying DNA replication initiation, as they contain two circular chromosomes. Chromosome II (chrII) replication is governed by two evolutionarily unique yet highly conserved elements, the origin DNA sequence <span class="hlt">ori</span>CII and the initiator protein RctB. The minimum functional region of <span class="hlt">ori</span>CII, <span class="hlt">ori</span>CII-min, contains multiple elements that are bound by RctB in vitro, but little is known about the specific requirements for individual elements during <span class="hlt">ori</span>CII initiation. We utilized undirected and site-specific mutagenesis to investigate the functionality of mutant forms of <span class="hlt">ori</span>CII-min and assessed binding to various mutant forms by RctB. Our analyses showed that deletions, point mutations, and changes in RctB target site spacing or methylation all impaired <span class="hlt">ori</span>CII-min-based replication. RctB displayed a reduced affinity for most of the low-efficacy origins tested, although its characteristic cooperative binding was generally maintained. Mutations that removed or altered the relative positions of origin components other than RctB binding sites (e.g., AT-rich sequence, DnaA target site) also abolished replicative capacity. Comprehensive mutagenesis and deep-sequencing-based screening (<span class="hlt">Ori</span>Seq) allowed the identification of a previously uncharacterized methylated domain in <span class="hlt">ori</span>CII that is required for origin function. Together, our results reveal the remarkable evolutionary honing of <span class="hlt">ori</span>CII and provide new insight into the complex interplay between RctB and <span class="hlt">ori</span>CII. PMID:26220967</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015csss...18.1065P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015csss...18.1065P"><span id="translatedtitle">Status of known T type sources towards the ? Orionis cluster</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Pena Ramirez, K.; Zapatero Osorio, M. R.; Bejar, V. J. S.</p> <p>2015-01-01</p> <p>We present the characterization of the three T type candidates (S <span class="hlt">Ori</span> 70, S <span class="hlt">Ori</span> 73, and S <span class="hlt">Ori</span> J053804.65-021352.5) lying in the line of sight towards ? Orionis (3 Myr, 352 pc, solar metallicity) by means of near-infrared photometric, astrometric, and spectroscopic studies. H-band methane images were collected for all three sources using the LIRIS instrument on the 4.2 m William Herschel Telescope. J-band spectra of resolution 500 were obtained for S <span class="hlt">Ori</span> J053804.65-021352.5 with the ISAAC spectrograph on the 8 m Very Large Telescope (VLT), and public low resolution (R50) JH spectra obtained with the Wide Field Camera 3 (WFC3) on board the Hubble Space Telescope (HST) were employed for the spectroscopic classification of S <span class="hlt">Ori</span> 70 and 73. Accurate proper motions with a typical uncertainty of 3 mas yr^{-1} were derived using ancient images and new data collected with ISAAC/VLT and WFC3/HST. The three objects were spectroscopically classified as T4.5 0.5 (S <span class="hlt">Ori</span> 73), T5 0.5 (S <span class="hlt">Ori</span> J053804.65-021352.5), and T7^{+0.5}_{-1.0} (S <span class="hlt">Ori</span> 70). These spectral types agree with the H-band methane colors. The proper motions of S <span class="hlt">Ori</span> 70 and 73 are larger than that of the cluster by >4 ?. The proper motion of S <span class="hlt">Ori</span> J053804.65-021352.5 is consistent with a null displacement during the time interval of 7.03 yr.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=364475','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=364475"><span id="translatedtitle">Activation of a mammalian origin of replication by chromosomal rearrangement.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Leu, T H; Hamlin, J L</p> <p>1992-01-01</p> <p>The methotrexate-resistant Chinese hamster cell line DC3F/A3-4K (A3/4K) contains at least two prominent dihydrofolate reductase amplicon types. The type I amplicons, constituting approximately 80% of the total, are at least 650 kb in length, but the endpoints have not yet been characterized. The type II sequences represent approximately 20% of amplicons, are 450 kb in length, and are arranged as alternating head-to-head and tail-to-tail repeats. In previous studies on the CHOC 400 line, in which the amplicons are much smaller, a replication initiation locus (<span class="hlt">ori-beta/ori</span>-gamma) has been shown to reside downstream from the dihydrofolate reductase gene. In a more recent study on the larger amplicons of A3/4K cells, we detected an additional initiation locus (<span class="hlt">ori</span>-alpha) lying approximately 240 kb upstream from <span class="hlt">ori-beta/ori</span>-gamma. Interestingly, in vivo labelling experiments suggested that replication forks diverge from <span class="hlt">ori</span>-alpha only in the downstream direction. This finding suggested either that <span class="hlt">ori</span>-alpha is a unidirectional origin or that a terminus lies immediately upstream from <span class="hlt">ori</span>-alpha. However, in this study, we show that <span class="hlt">ori</span>-alpha is actually very close to the head-to-head palindromic junction sequence between the minor type II amplicons in A3/4K cells; furthermore, <span class="hlt">ori</span>-alpha is active in the early S period in the type II amplicons but not in the larger type I sequences that lack this palindromic junction. This is the first direct demonstration in mammalian cells that a cryptic origin can be activated by chromosomal rearrangement, presumably by deleting negative regulatory elements or by creating a more favorable chromosomal milieu for initiation. Images PMID:1588972</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013AIPC.1543..184N','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013AIPC.1543..184N"><span id="translatedtitle">Second outburst phase of a young eruptive star V1647 Orionis (McNeil's nebula)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ninan, J. P.; Ojha, D. K.; Mallick, K. K.; Ghosh, S. K.; Joshi, J. S.</p> <p>2013-06-01</p> <p>Young low mass stars still embedded in dust and molecular gas pass through a stage of outbursts. These outbursts are due to sudden increase in accretion rate from the inner disc. V1647 Orionis underwent an FU <span class="hlt">Ori</span> kind of outburst in 2004 and returned to its pre-outburst phase in early 2006. Within just 2 years it again underwent a second outburst in 2008; such an event is rarely seen in FU <span class="hlt">Ori</span> type of outburst. We therefore followed the source in its second outburst phase from 2-m Himalayan Chandra Telescope (HCT) and 2-m IUCAA Girawali Observatory (IGO) Telescope. Our optical and near-infrared (NIR) photometric data show that the source is undergoing a slow but steady dimming of 0.3 - 0.5 mag since the recent second outburst. It seems that the observed properties of the outburst of V1647 <span class="hlt">Ori</span> are different from both the EX <span class="hlt">Ori</span> and FU <span class="hlt">Ori</span> type of outbursts, and suggest that this star probably represents a new type of eruptive young star, to be different from both FU <span class="hlt">Ori</span> and EX <span class="hlt">Ori</span> classes.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26528583','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26528583"><span id="translatedtitle">Identification of metabolites of oridonin in rats with a single run on UPLC-Triple-TOF-MS/MS system based on multiple mass defect filter data acquisition and multiple data processing techniques.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tian, Tingting; Jin, Yiran; Ma, Yinghua; Xie, Weiwei; Xu, Huijun; Zhang, Kerong; Zhang, Lantong; Du, Yingfeng</p> <p>2015-12-01</p> <p>Oridonin (<span class="hlt">ORI</span>) is an active natural ent-kaurane diterpenoid ingredient originating from well-known traditional Chinese herb medicine and is expected to be pursued as a new anticancer agent. In the present study, a novel and efficient approach was developed for in vivo screening and identification of <span class="hlt">ORI</span> metabolites using ultra high performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UPLC-Triple-TOF-MS/MS). This analytical strategy was as follows: an effective on-line data acquisition method multiple mass defect filter (MMDF) combined with dynamic background subtraction (DBS), was developed to trace all of potential metabolites of <span class="hlt">ORI</span>. The MMDF and DBS method could trigger an information dependent acquisition scan, which could give the information of low-level metabolites masked by background noise and endogenous components in complex matrix. Moreover, the sensitive and specific multiple data-mining techniques including extracted ion chromatography, mass defect filtering, product ion filtering and neutral loss filtering were employed to identify the metabolites of <span class="hlt">ORI</span>. Then, structures for the metabolites were successfully assigned based on accurate masses, the mass fragmentation of <span class="hlt">ORI</span> and metabolic knowledge. Finally, an important parameter Clog P was used to estimate the retention time of isomers. Based on the proposed strategy, 16 phase I and 2 phase II metabolites were detected in rats after oral administration of <span class="hlt">ORI</span>. The main biotransformation route of <span class="hlt">ORI</span> was identified as reduction, oxidation, dehydroxylation and glucuronic acid conjugation. This is the first study of <span class="hlt">ORI</span> metabolism in vivo. This study not only proposed a practical strategy for rapidly screening and identifying metabolites, but also provided useful information for further study of the pharmacology and mechanism of <span class="hlt">ORI</span> in vivo. At the same time this methodology can be widely applied for the structural characterization of the metabolites of other ent-kaurane diterpenoid. PMID:26528583</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/22034699','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/22034699"><span id="translatedtitle">THE NATURE AND EVOLUTIONARY STATE OF THE FU ORIONIS BINARY SYSTEM</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Beck, Tracy L.; Aspin, C. E-mail: caa@ifa.hawaii.edu</p> <p>2012-03-15</p> <p>In this paper, we present the results of our adaptive optics fed three-dimensional imaging spectroscopy study of the FU Orionis binary system. Although the 0.''5 separation companion to FU <span class="hlt">Ori</span> is {approx}4 mag fainter, we have easily spatially resolved it in the J, H, and K infrared bands and extract high signal-to-noise spectra of the two stellar components from 1.15 to 2.4 {mu}m. We derive a spectral type of K5{sup +2}{sub -1} for FU <span class="hlt">Ori</span> S based on the stellar photospheric absorption features and find that it is an actively accreting young star (M-dot{sub acc}{approx} (2-3) Multiplication-Sign 10{sup -8} M{sub Sun} yr{sup -1}) that is likely gravitationally bound to FU <span class="hlt">Ori</span>. We have found that the continuum shape of FU <span class="hlt">Ori</span> S is not well fit by our spectral modeling process, and this results in a large uncertainty in the line-of-sight extinction to the star. Yet, by placing FU <span class="hlt">Ori</span> S on the Hertzsprung-Russell diagram and comparing its estimated location with evolutionary models, we find that it is best fit as a {approx}1.2 M{sub Sun} star with a likely age of less than {approx}2 Myr. If we assume coevality of the stellar components, we have thus placed an estimated age on the FU <span class="hlt">Ori</span> system. Moreover, assuming the canonical model for the nature of FU <span class="hlt">Ori</span> in that its optical and infrared absorption features arise primarily from the inner circumstellar disk around a {approx}0.3 M{sub Sun} star, we find that the fainter FU <span class="hlt">Ori</span> S component is actually the more massive star in the system. Future monitoring of FU <span class="hlt">Ori</span> S to investigate flux variability and orbital motion should further clarify the nature of this curious young binary.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/21464588','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/21464588"><span id="translatedtitle">CHANDRA REVEALS VARIABLE MULTI-COMPONENT X-RAY EMISSION FROM FU ORIONIS</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Skinner, Stephen L.; Guedel, Manuel; Briggs, Kevin R.; Lamzin, Sergei A.</p> <p>2010-10-20</p> <p>FU Orionis is the prototype of a class of eruptive young stars ('FUors') characterized by strong optical outbursts. We recently completed an exploratory survey of FUors using XMM-Newton to determine their X-ray properties, about which little was previously known. The prototype FU <span class="hlt">Ori</span> and V1735 Cyg were detected. The X-ray spectrum of FU <span class="hlt">Ori</span> was found to be unusual, consisting of a cool moderately absorbed component plus a hotter component viewed through an absorption column density that is an order of magnitude higher. We present here a sensitive (99 ks) follow-up X-ray observation of FU <span class="hlt">Ori</span> obtained at higher angular resolution with Chandra ACIS-S. The unusual multi-component spectrum is confirmed. The hot component is centered on FU <span class="hlt">Ori</span> and dominates the emission above 2 keV. It is variable (a signature of magnetic activity) and is probably coronal emission originating close to FU <span class="hlt">Ori</span>'s surface viewed through cool gas in FU <span class="hlt">Ori</span>'s strong wind or accretion stream. In contrast, the X-ray centroid of the soft emission below 2 keV is offset 0.''20 to the southeast of FU <span class="hlt">Ori</span>, toward the near-IR companion (FU <span class="hlt">Ori</span> S). This offset amounts to slightly less than half the separation between the two stars. The most likely explanation for the offset is that the companion contributes significantly to the softer X-ray emission below 2 keV (and weakly above 2 keV). The superimposed X-ray contributions from FU <span class="hlt">Ori</span> and the companion resolve the paradox posed by XMM-Newton of an apparently single X-ray source viewed through two different absorption columns.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3893580','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3893580"><span id="translatedtitle">Healthy lifestyle and risk of breast cancer for indigenous and non-indigenous women in New Zealand: a case control study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2014-01-01</p> <p>Background The reasons for the increasing breast cancer incidence in indigenous Mā<span class="hlt">ori</span> compared to non-Mā<span class="hlt">ori</span> New Zealand women are unknown. The aim of this study was to assess the association of an index of combined healthy lifestyle behaviours with the risk of breast cancer in Mā<span class="hlt">ori</span> and non-Mā<span class="hlt">ori</span> women. Methods A population-based case–control study was conducted, including breast cancer cases registered in New Zealand from 2005–2007. Controls were matched by ethnicity and 5-year age bands. A healthy lifestyle index score (HLIS) was generated for 1093 cases and 2118 controls, based on public health and cancer prevention recommendations. The HLIS was constructed from eleven factors (limiting red meat, cream, and cheese; consuming more white meat, fish, fruit and vegetables; lower alcohol consumption; not smoking; higher exercise levels; lower body mass index; and longer cumulative duration of breastfeeding). Equal weight was given to each factor. Logistic regression was used to estimate the associations between breast cancer and the HLIS for each ethnic group stratified by menopausal status. Results Among Mā<span class="hlt">ori</span>, the mean HLIS was 5.00 (range 1–9); among non-Mā<span class="hlt">ori</span> the mean was 5.43 (range 1.5-10.5). There was little evidence of an association between the HLIS and breast cancer for non-Mā<span class="hlt">ori</span> women. Among postmenopausal Mā<span class="hlt">ori</span>, those in the top HLIS tertile had a significantly lower odds of breast cancer (Odds Ratio 0.47, 95% confidence interval 0.23-0.94) compared to those in the bottom tertile. Conclusion These findings suggest that healthy lifestyle recommendations could be important for reducing breast cancer risk in postmenopausal Mā<span class="hlt">ori</span> women. PMID:24410858</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014A%26A...570A.118F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014A%26A...570A.118F"><span id="translatedtitle">GW Orionis: Inner disk readjustments in a triple system</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Fang, M.; Sicilia-Aguilar, A.; Roccatagliata, V.; Fedele, D.; Henning, Th.; Eiroa, C.; Mller, A.</p> <p>2014-10-01</p> <p>Context. Disks are expected to dissipate quickly in binary or multiple systems. Investigating such systems can improve our knowledge of the disk dispersal. The triple system GW <span class="hlt">Ori</span>, still harboring a massive disk, is an excellent target. Aims: We study the young stellar system GW <span class="hlt">Ori</span>, concentrating on its accretion, wind activity and disk properties. Methods: We use high-resolution optical spectra of GW <span class="hlt">Ori</span> to do spectral classification and derive the radial velocities (RV). We analyze the wind and accretion activity using the emission lines in the spectra. We also use U-band photometry, which has been collected from the literature, to study the accretion variability of GW <span class="hlt">Ori</span>. We characterize the disk properties of GW <span class="hlt">Ori</span> by modeling its spectral energy distribution (SED). Results.By comparing our data to the synthetical spectra, we classify GW <span class="hlt">Ori</span> as a G8 star. Based on the RVs derived from the optical spectra, we confirm the previous result as a close companion in GW <span class="hlt">Ori</span> with a period of ~242 days and an orbital semi-major axis of ~1 AU. The RV residuals after the subtraction of the orbital solution with the equivalent widths (EW) of accretion-related emission lines vary with periods of 5-6.7 days during short-time intervals, which are caused by the rotational modulation. The H? and H? line profiles of GW <span class="hlt">Ori</span> can be decomposed in two central-peaked emission components and one blue-shifted absorption component. The blue-shifted absorption components are due to a disk wind modulated by the orbital motion of the close companion. Therefore, the systems like GW <span class="hlt">Ori</span> can be used to study the extent of disk winds. We find that the accretion rates of GW <span class="hlt">Ori</span> are rather constant but can occasionally be enhanced by a factor of 2-3. We reproduce the SED of GW <span class="hlt">Ori</span> by using disk models with gaps ~25-55 AU in size. A small population of tiny dust particles within the gap produces the excess emission at near-infrared bands and the strong and sharp silicate feature at 10 ?m. The SED of GW <span class="hlt">Ori</span> exhibits dramatic changes on timescales of ~20 yr in the near-infrared bands, which can be explained as the change in the amount and distribution of small dust grains in the gap. We collect a sample of binary/multiple systems with disks in the literature and find a strong positive correlation between their gap sizes and separations from the primaries to companions, which is generally consistent with the prediction from the theory. Table 4 is available in electronic form at http://www.aanda.org</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4388369','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4388369"><span id="translatedtitle">Breast Cancer Biology and Ethnic Disparities in Breast Cancer Mortality in New Zealand: A Cohort Study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Seneviratne, Sanjeewa; Lawrenson, Ross; Scott, Nina; Kim, Boa; Shirley, Rachel; Campbell, Ian</p> <p>2015-01-01</p> <p>Introduction Indigenous M?<span class="hlt">ori</span> women have a 60% higher breast cancer mortality rate compared with European women in New Zealand. We investigated differences in cancer biological characteristics and their impact on breast cancer mortality disparity between M?<span class="hlt">ori</span> and NZ European women. Materials and Methods Data on 2849 women with primary invasive breast cancers diagnosed between 1999 and 2012 were extracted from the Waikato Breast Cancer Register. Differences in distribution of cancer biological characteristics between M?<span class="hlt">ori</span> and NZ European women were explored adjusting for age and socioeconomic deprivation in logistic regression models. Impacts of socioeconomic deprivation, stage and cancer biological characteristics on breast cancer mortality disparity between M?<span class="hlt">ori</span> and NZ European women were explored in Cox regression models. Results Compared with NZ European women (n=2304), M?<span class="hlt">ori</span> women (n=429) had significantly higher rates of advanced and higher grade cancers. M?<span class="hlt">ori</span> women also had non-significantly higher rates of ER/PR negative and HER-2 positive breast cancers. Higher odds of advanced stage and higher grade remained significant for M?<span class="hlt">ori</span> after adjusting for age and deprivation. M?<span class="hlt">ori</span> women had almost a 100% higher age and deprivation adjusted breast cancer mortality hazard compared with NZ European women (HR=1.98, 1.55-2.54). Advanced stage and lower proportion of screen detected cancer in M?<span class="hlt">ori</span> explained a greater portion of the excess breast cancer mortality (HR reduction from 1.98 to 1.38), while the additional contribution through biological differences were minimal (HR reduction from 1.38 to 1.35). Conclusions More advanced cancer stage at diagnosis has the greatest impact while differences in biological characteristics appear to be a minor contributor for inequities in breast cancer mortality between M?<span class="hlt">ori</span> and NZ European women. Strategies aimed at reducing breast cancer mortality in M?<span class="hlt">ori</span> should focus on earlier diagnosis, which will likely have a greater impact on reducing breast cancer mortality inequity between M?<span class="hlt">ori</span> and NZ European women. PMID:25849101</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4066892','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4066892"><span id="translatedtitle">Complex of the herpes simplex virus type 1 origin binding protein UL9 with DNA as a platform for the design of a new type of antiviral drugs</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Bazhulina, N.P.; Surovaya, A.N.; Gursky, Y.G.; Andronova, V.L.; Moiseeva, E.D.; Nikitin, A.M.; Golovkin, M.V.; Galegov, G.A.; Grokhovsky, S.L.; Gursky, G.V.</p> <p>2013-01-01</p> <p>The herpes simplex virus type 1 origin-binding protein, OBP, is a DNA helicase encoded by the UL9 gene. The protein binds in a sequence-specific manner to the viral origins of replication, two <span class="hlt">OriS</span> sites and one <span class="hlt">Ori</span>L site. In order to search for efficient inhibitors of the OBP activity, we have obtained a recombinant origin-binding protein expressed in Escherichia coli cells. The UL9 gene has been amplified by PCR and inserted into a modified plasmid pET14 between NdeI and KpnI sites. The recombinant protein binds to Box I and Box II sequences and possesses helicase and ATPase activities. In the presence of ATP and viral protein ICP8 (single-strand DNA-binding protein), the initiator protein induces unwinding of the minimal <span class="hlt">OriS</span> duplex (?80 bp). The protein also binds to a single-stranded DNA (<span class="hlt">OriS</span>*) containing a stable Box I-Box III hairpin and an unstable AT-rich hairpin at the 3?-end. In the present work, new minor groove binding ligands have been synthesized which are capable to inhibit the development of virus-induced cytopathic effect in cultured Vero cells. Studies on binding of these compounds to DNA and synthetic oligonucleotides have been performed by fluorescence methods, gel mobility shift analysis and footprinting assays. Footprinting studies have revealed that Pt-bis-netropsin and related molecules exhibit preferences for binding to the AT-spacer in <span class="hlt">OriS</span>. The drugs stabilize structure of the AT-rich region and inhibit the fluctuation opening of AT-base pairs which is a prerequisite to unwinding of DNA by OBP. Kinetics of ATP-dependent unwinding of <span class="hlt">OriS</span> in the presence and absence of netropsin derivatives have been studied by measuring the efficiency of Forster resonance energy transfer (FRET) between fluorophores attached to 5?- and 3?- ends of an oligonucleotide in the minimal <span class="hlt">OriS</span> duplex. The results are consistent with the suggestion that OBP is the DNA Holiday junction (HJ) binding helicase. The protein induces conformation changes (bending and partial melting) of <span class="hlt">OriS</span> duplexes and stimulates HJ formation in the absence of ATP. The antiviral activity of bis-netropsins is coupled with their ability to inhibit the fluctuation opening of AT base pairs in the A + T cluster and their capacity to stabilize the structure of the AT-rich hairpin in the single-stranded oligonucleotide corresponding to the upper chain in the minimal duplex <span class="hlt">OriS</span>. The antiviral activities of bis-netropsins in cell culture and their therapeutic effects on HSV1-infected laboratory animals have been studied. PMID:23879454</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/20616918','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/20616918"><span id="translatedtitle">Current techniques in surgical correction of congenital ptosis.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Allard, Felicia D; Durairaj, Vikram D</p> <p>2010-04-01</p> <p>Ptosis refers to vertical narrowing of the palpebral fissure secondary to drooping of the upper eyelid to a lower than normal position. Ptosis is considered congenital if present at birth or if it is diagnosed within the first year of life. Correction of congenital ptosis is one of the most difficult challenges ophthalmologists face. Multiple surgical procedures are available including, frontalis sling, <span class="hlt">levator</span> advancement, Whitnall sling, frontalis muscle flap, and Mullerectomy. Selection of one technique over another depends on the consideration of several factors including the surgeon experience, the degree of ptosis in the patient, as well as the degree of <span class="hlt">levator</span> muscle function. Current recommendations for the correction of congential ptosis vary based on clinical presentation. Advantages and disadvantages of each of these procedures are presented with recommendations to avoid complications. PMID:20616918</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4413093','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4413093"><span id="translatedtitle">Inverse Bell’s Phenomenon: Rare Ophthalmic Finding Following Ptosis Surgery</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Jakkal, Tapan; Khaire, Bhasakar</p> <p>2015-01-01</p> <p>Bell’s phenomenon is protective reflex in which the globe is turned upwards and slightly outwards during the eyelid closure to avoid corneal exposure. In Inverse Bell’s phenomenon, the eye moves downward instead of upward, this may be seen in the normal population, patients with Bell’s palsy or following conjunctival scarring. We hereby present the unusual complication of transient inversion of Bell’s phenomenon following extensive <span class="hlt">levator</span> resection surgery performed for congenital ptosis. A 24-year-old male was undergone ptosis correction surgery. On postoperative day two, ocular examination revealed down rolling of eye ball during eyelid closure. It underwent spontaneous resolution within four weeks without any corneal complication. The patients were given frequent lubricating eye drops during this period and advised frequent follow-up for early diagnosis of corneal complication. Here we highlight an inverse Bell’s phenomenon following <span class="hlt">levator</span> resection surgery, its possible mechanism and risk of corneal complication. PMID:25954644</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19820021110','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19820021110"><span id="translatedtitle">Testosterone enhances C-14 2-deoxyglucose uptake by striated muscle. [sex hormones and muscle</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Toop, J.; Max, S. R.</p> <p>1982-01-01</p> <p>The effect of testosterone propionate (TP) on C-14 2-deoxyglucose (C-14 2DG) uptake was studied in the rat <span class="hlt">levator</span> ani muscle in vivo using the autoradiographic technique. Following a delay of 1 to 3 h after injecting TP, the rate of C-14 2DG uptake in experimental animals began to increase and continued to increase for at least 20 h. The label, which corresponds to C-14 2-deoxyglucose 6-phosphate, as demonstrated by chromatographic analysis of muscle extracts, was uniformly distributed over the entire muscle and was predominantly in muscle fibers, although nonmuscular elements were also labeled. The 1 to 3 h time lag suggests that the TP effect may be genomic, acting via androgen receptors, rather than directly on muscle membranes. Acceleration of glucose uptake may be an important early event in the anabolic response of the rat <span class="hlt">levator</span> ani muscle to androgens.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/6466190','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/6466190"><span id="translatedtitle">Oriental eyelids. An anatomic study.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Doxanas, M T; Anderson, R L</p> <p>1984-08-01</p> <p>Dissection of the eyelids and sagittal sections of the orbital blocks identified the anatomic features of the oriental eyelids responsible for their unique appearance. The basic distinction involves the formation of the eyelid crease and fold. In the occidental eyelid, the orbital septum fuses with the <span class="hlt">levator</span> aponeurosis below the superior tarsal border. However, in the oriental eyelid, the orbital septum fuses with the <span class="hlt">levator</span> aponeurosis below the superior tarsal border. The accompanying preaponeurotic or orbital fat is allowed to proceed to the anterior tarsal surface, resulting in a full or thickened eyelid. The inferior extension of the orbital septum, beyond the superior tarsal border, prevents anterior aponeurotic fibers from fanning toward the subcutaneous tissues to produce the normal eyelid crease. Appreciation of the unique anatomic features of oriental eyelids is important for those persons who evaluate or surgically explore these eyelids. PMID:6466190</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25954644','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25954644"><span id="translatedtitle">Inverse Bell's Phenomenon: Rare Ophthalmic Finding Following Ptosis Surgery.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Shitole, Satish; Jakkal, Tapan; Khaire, Bhasakar</p> <p>2015-03-01</p> <p>Bell's phenomenon is protective reflex in which the globe is turned upwards and slightly outwards during the eyelid closure to avoid corneal exposure. In Inverse Bell's phenomenon, the eye moves downward instead of upward, this may be seen in the normal population, patients with Bell's palsy or following conjunctival scarring. We hereby present the unusual complication of transient inversion of Bell's phenomenon following extensive <span class="hlt">levator</span> resection surgery performed for congenital ptosis. A 24-year-old male was undergone ptosis correction surgery. On postoperative day two, ocular examination revealed down rolling of eye ball during eyelid closure. It underwent spontaneous resolution within four weeks without any corneal complication. The patients were given frequent lubricating eye drops during this period and advised frequent follow-up for early diagnosis of corneal complication. Here we highlight an inverse Bell's phenomenon following <span class="hlt">levator</span> resection surgery, its possible mechanism and risk of corneal complication. PMID:25954644</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24828860','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24828860"><span id="translatedtitle">The oculocardiac reflex in aponeurotic blepharoptosis surgery.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Uda, Hirokazu; Sugawara, Yasusih; Sarukawa, Syunji; Sunaga, Ataru</p> <p>2014-06-01</p> <p>The purpose of this study was to investigate the correlation between the oculocardiac reflex (OCR) and blepharoptosis surgery for safe eyelid surgery. Fifty-four consecutive patients with bilateral aponeurotic blepharoptosis were enrolled in this study. Changes in electrocardiography (ECG) monitoring were recorded during surgery. Preoperative pressing on the globe and intraoperative stretching of the <span class="hlt">levator</span> aponeurosis were also carried out and the occurrence rate of the OCR was recorded. A positive OCR was observed in 12 patients (22.2%) in the preoperative globe-pressing test, whereas a positive OCR was observed in 22 patients (40.7%) in the <span class="hlt">levator</span>-stretching test. The <span class="hlt">levator</span>-stretching test did not indicate a significant difference in the rate of heart rate decrease with respect to laterality. No correlation was observed between age and the occurrence of OCR. On the other hand, there was a significant difference in the percentage of heart rate decrease between patients with positive OCR and negative OCR as determined in the globe-pressing test (mean = 13.1% vs. 5.4%). During the practical operative manoeuvre, no bradycardia was observed in any case. This study confirmed that a rapid and strong traction of <span class="hlt">levator</span> aponeurosis induces the OCR regardless of laterality and age. Atraumatic and gentle handling are essential to prevent OCR. The preoperative globe-pressing test may be an index of the OCR in reflex-prone patients. Intraoperative ECG monitoring will be useful for early onset detection, although positive OCR was not observed in any patient during the practical surgical manoeuvre. PMID:24828860</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li class="active"><span>15</span></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_15 --> <div id="page_16" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active"><span>16</span></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="301"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4520777','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4520777"><span id="translatedtitle">The Dilator Naris Muscle as a Reporter of Facial Nerve Regeneration in a Rat Model</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Weinberg, Julie S.; Kleiss, Ingrid J.; Knox, Christopher J.; Heaton, James T.; Hadlock, Tessa A.</p> <p>2015-01-01</p> <p>Objective Many investigators study facial nerve regeneration using the rat whisker pad model, though widely standardized outcomes measures of facial nerve regeneration in the rodent have not yet been developed. The intrinsic whisker pad “sling” muscles producing whisker protraction, situated at the base of each individual whisker, are extremely small and difficult to study en bloc. Here, we compare the functional innervation of two potential reporter muscles for whisker pad innervation: the dilator naris and the <span class="hlt">levator</span> labii superioris, to characterize facial nerve regeneration. Methods Motor supply of the dilator naris and <span class="hlt">levator</span> labii superioris was elucidated by measuring contraction force and compound muscle action potentials during stimulation of individual facial nerve branches, and by measuring whisking amplitude before and after dilator naris distal tendon release. Results The pattern of dilator naris innervation matched that of the intrinsic whisker pad musculature (i.e. via the buccal and marginal mandibular branches of the facial nerve), whereas the <span class="hlt">levator</span> labii superioris appeared to be innervated almost entirely by the zygomatic branch, whose primary target is the orbicularis oculi muscle. Conclusion While the <span class="hlt">levator</span> labii superioris has been commonly used as a reporter muscle of whisker pad innervation, the present data show that its innervation pattern does not overlap substantially with the muscles producing whisker protraction. The dilator naris muscle may serve as a more appropriate reporter for whisker pad innervation because it is innervated by the same facial nerve branches as the intrinsic whisker pad musculature, making structure\\function correlations more accurate, and more relevant to investigators studying facial nerve regeneration. PMID:25643189</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/7608667','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/7608667"><span id="translatedtitle">Electromyography and recovery of the blink reflex in involuntary eyelid closure: a comparative study.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Aramideh, M; Eekhof, J L; Bour, L J; Koelman, J H; Speelman, J D; Ongerboer de Visser, B W</p> <p>1995-06-01</p> <p>Electromyographic (EMG) activity of orbicularis oculi and <span class="hlt">levator</span> palpebrae muscles was recorded to study the origin of involuntary eyelid closure in 33 patients. The evoked blink reflex in all patients and in 23 controls was also studied. To examine the excitability of facial motoneurons and bulbar interneurons in individual patients and to compare the results with EMG findings, R1 and R2 recovery indices were calculated in all subjects, as the average of recovery values at 0.5, 0.3, and 0.21 second interstimulus intervals. Based on EMG patterns, the patients were divided into three subclasses: EMG subclass 1, 10 patients with involuntary discharges solely in orbicularis oculi muscle; EMG subclass 2, 20 patients with involuntary discharges in orbicularis oculi and either involuntary <span class="hlt">levator</span> palpebrae inhibition or a disturbed reciprocal innervation between orbicularis oculi and <span class="hlt">levator</span> palpebrae; EMG subclass 3, three patients who did not have blepharospasm, but had involuntary <span class="hlt">levator</span> palpebrae inhibition in association with a basal ganglia disease. The total patient group showed an enhanced recovery of both R1 and R2 components compared with controls. Although 30 out of 33 patients had blepharospasm (EMG subclasses 1 and 2), R1 recovery index was normal in 64% and R2 recovery index was normal in 54%. Patients with an abnormal R2 recovery index had an abnormal R1 recovery index significantly more often. All patients from EMG subclass 1 had an abnormal R2 recovery index, whereas all patients from EMG subclass 3 had normal recovery indices for both R1 and R2 responses. Seventy five per cent of the patients from EMG subclass 2 had normal recovery indices. The results provide further evidence that physiologically blepharospasm is not a homogeneous disease entity, and indicate that different pathophysiological mechanisms at the suprasegmental, or segmental level, or both are involved. PMID:7608667</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1073546','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1073546"><span id="translatedtitle">Electromyography and recovery of the blink reflex in involuntary eyelid closure: a comparative study.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Aramideh, M; Eekhof, J L; Bour, L J; Koelman, J H; Speelman, J D; Ongerboer de Visser, B W</p> <p>1995-01-01</p> <p>Electromyographic (EMG) activity of orbicularis oculi and <span class="hlt">levator</span> palpebrae muscles was recorded to study the origin of involuntary eyelid closure in 33 patients. The evoked blink reflex in all patients and in 23 controls was also studied. To examine the excitability of facial motoneurons and bulbar interneurons in individual patients and to compare the results with EMG findings, R1 and R2 recovery indices were calculated in all subjects, as the average of recovery values at 0.5, 0.3, and 0.21 second interstimulus intervals. Based on EMG patterns, the patients were divided into three subclasses: EMG subclass 1, 10 patients with involuntary discharges solely in orbicularis oculi muscle; EMG subclass 2, 20 patients with involuntary discharges in orbicularis oculi and either involuntary <span class="hlt">levator</span> palpebrae inhibition or a disturbed reciprocal innervation between orbicularis oculi and <span class="hlt">levator</span> palpebrae; EMG subclass 3, three patients who did not have blepharospasm, but had involuntary <span class="hlt">levator</span> palpebrae inhibition in association with a basal ganglia disease. The total patient group showed an enhanced recovery of both R1 and R2 components compared with controls. Although 30 out of 33 patients had blepharospasm (EMG subclasses 1 and 2), R1 recovery index was normal in 64% and R2 recovery index was normal in 54%. Patients with an abnormal R2 recovery index had an abnormal R1 recovery index significantly more often. All patients from EMG subclass 1 had an abnormal R2 recovery index, whereas all patients from EMG subclass 3 had normal recovery indices for both R1 and R2 responses. Seventy five per cent of the patients from EMG subclass 2 had normal recovery indices. The results provide further evidence that physiologically blepharospasm is not a homogeneous disease entity, and indicate that different pathophysiological mechanisms at the suprasegmental, or segmental level, or both are involved. PMID:7608667</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/6703603','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/6703603"><span id="translatedtitle">The improvement of the gummy smile using the implant spacer technique.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ellenbogen, R; Swara, N</p> <p>1984-01-01</p> <p>A simple technique for correction of a gummy smile by partially transecting the <span class="hlt">levator</span> labii superioris, the major lip elevator, and decreasing its cephalic excursion using an implant spacer is presented. Results are given for 21 patients, and 3 representative patients are discussed, in whom a silicone implant with maxillary augmentation with concomitant rhinoplasty; cartilage from the nasal septum with concomitant rhinoplasty; and a silicone implant independent of rhinoplasty without maxillary augmentation were utilized. PMID:6703603</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21288885','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21288885"><span id="translatedtitle">Two forms of ribosomal protein L2 of Escherichia coli that inhibit DnaA in DNA replication.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chodavarapu, Sundari; Felczak, Magdalena M; Kaguni, Jon M</p> <p>2011-05-01</p> <p>We purified an inhibitor of <span class="hlt">ori</span>C plasmid replication and determined that it is a truncated form of ribosomal protein L2 evidently lacking 59 amino acid residues from the C-terminal region encoded by rplB. We show that this truncated form of L2 or mature L2 physically interacts with the N-terminal region of DnaA to inhibit initiation from <span class="hlt">ori</span>C by apparently interfering with DnaA oligomer formation, and the subsequent assembly of the prepriming complex on an <span class="hlt">ori</span>C plasmid. Both forms of L2 also inhibit the unwinding of <span class="hlt">ori</span>C by DnaA. These in vitro results raise the possibility that one or both forms of L2 modulate DnaA function in vivo to regulate the frequency of initiation. PMID:21288885</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3105425','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3105425"><span id="translatedtitle">Two forms of ribosomal protein L2 of Escherichia coli that inhibit DnaA in DNA replication</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Chodavarapu, Sundari; Felczak, Magdalena M.; Kaguni, Jon M.</p> <p>2011-01-01</p> <p>We purified an inhibitor of <span class="hlt">ori</span>C plasmid replication and determined that it is a truncated form of ribosomal protein L2 evidently lacking 59 amino acid residues from the C-terminal region encoded by rplB. We show that this truncated form of L2 or mature L2 physically interacts with the N-terminal region of DnaA to inhibit initiation from <span class="hlt">ori</span>C by apparently interfering with DnaA oligomer formation, and the subsequent assembly of the prepriming complex on an <span class="hlt">ori</span>C plasmid. Both forms of L2 also inhibit the unwinding of <span class="hlt">ori</span>C by DnaA. These in vitro results raise the possibility that one or both forms of L2 modulate DnaA function in vivo to regulate the frequency of initiation. PMID:21288885</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-101.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-101.pdf"><span id="translatedtitle">42 CFR 93.101 - Purpose.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... the integrity of PHS supported research and the research process, and conserve public funds. ... HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT General... Office of Research Integrity (<span class="hlt">ORI</span>), and institutions in responding to research misconduct issues;...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-101.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-101.pdf"><span id="translatedtitle">42 CFR 93.101 - Purpose.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... the integrity of PHS supported research and the research process, and conserve public funds. ... HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT General... Office of Research Integrity (<span class="hlt">ORI</span>), and institutions in responding to research misconduct issues;...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2013-04-30/pdf/2013-10085.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2013-04-30/pdf/2013-10085.pdf"><span id="translatedtitle">78 FR 25274 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2013-04-30</p> <p>... submitted to <span class="hlt">ORI</span> for approval; the supervision plan must be designed to ensure the scientific integrity of... committee, board, and/or peer review committee, or as a consultant. FOR FURTHER INFORMATION...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2011-04-27/pdf/2011-10150.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2011-04-27/pdf/2011-10150.pdf"><span id="translatedtitle">76 FR 23599 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2011-04-27</p> <p>... commonly accepted within the scientific community for proposing, conducting, and/or reporting research. <span class="hlt">ORI</span>... limited to service on any PHS advisory committee, board, and/or peer review committee, or as a...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=136845','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=136845"><span id="translatedtitle">Colonization of Fopius ceratitivorus, A Newly Discovered African Egg-Pupal Parasitoid (Hymenoptera: Braconidae) of Ceratitis Capitata (Diptera: Tephritidae)</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>Fopius ceratitivorus Wharton is a recently discovered braconid parasitoid of the Mediterranean fruit fly (= medfly), Ceratitis capitata (Wied.). Unlike other parasitoids previously used in medfly biological control, F. ceratitivorus was originally collected from medfly in its purported region of <span class="hlt">ori</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=204323','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=204323"><span id="translatedtitle">A Comparative Study of Normalization Methods Used in Statistical Analysis of Oligonucleotide Microarray Data</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>Normalization methods used in the statistical analysis of oligonucleotide microarray data were evaluated. The oligonucleotide microarray is considered an efficient analytical tool for analyzing thousands of genes simultaneously in a single experiment. However, systematic variation in microarray, <span class="hlt">ori</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=555453','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=555453"><span id="translatedtitle">High efficiency of replication and expression of foreign genes in SV40-transformed human fibroblasts.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Boast, S; La Mantia, G; Lania, L; Blasi, F</p> <p>1983-01-01</p> <p>Human fibroblasts (HF) were transformed in vitro with origin-defective SV40 DNA (<span class="hlt">ori</span>-) using the calcium phosphate co-precipitation technique. The SV40 <span class="hlt">ori</span>- transformed human cells (HSF) were able to replicate efficiently a recombinant DNA molecule containing the <span class="hlt">ori</span> sequence of SV40 DNA. Transfection of HFS with pTBC1, a recombinant pi vx plasmid containing the herpes simplex virus thymidine kinase (HSV-TK) gene and the <span class="hlt">ori</span> SV40 sequences, results in high levels of TK mRNA of correct size. The pTBC1 plasmid does not appear to contain 'poison' sequences and can be efficiently re-established in Escherichia coli after replication in human cells. This host vector system may be of great usefulness in studying the expression of human genes in human cells. Images Fig. 2. Figure 3. PMID:6321161</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2013-12-04/pdf/2013-28887.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2013-12-04/pdf/2013-28887.pdf"><span id="translatedtitle">78 FR 72892 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2013-12-04</p> <p>... Manager, DNA Extraction and Staging Laboratory (DESL), SAIC-Frederick, Inc., the Operations and Technical..., <span class="hlt">ORI</span> found that Respondent fabricated the quantitative and qualitative data for RNA and DNA...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2007ApJ...661.1119B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2007ApJ...661.1119B"><span id="translatedtitle">25 Orionis: A Kinematically Distinct 10 Myr Old Group in Orion OB1a</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Briceo, Csar; Hartmann, Lee; Hernndez, Jess; Calvet, Nuria; Vivas, A. Katherina; Furesz, Gabor; Szentgyorgyi, Andrew</p> <p>2007-06-01</p> <p>We report here on the photometric and kinematic properties of a well-defined group of nearly 200 low-mass pre-main-sequence stars, concentrated within ~1 of the early-B star 25 <span class="hlt">Ori</span>, in the Orion OB1a subassociation. We refer to this stellar aggregate as the 25 Orionis group. The group also harbors the Herbig Ae/Be star V346 <span class="hlt">Ori</span> and a dozen other early-type stars with photometry, parallaxes, and some with IR excess emission, indicative of group membership. The number of high- and low-mass stars is in agreement with expectations from a standard initial mass function. The velocity distribution for the low-mass stars shows a narrow peak at 19.7 km s-1, offset ~-10 km s-1 from the velocity characterizing the younger stars of the <span class="hlt">Ori</span> OB1b subassociation, and -4 km s-1 from the velocity of widely spread young stars of the <span class="hlt">Ori</span> OB1a population; this result provides new and compelling evidence that the 25 <span class="hlt">Ori</span> group is a distinct kinematic entity, and that considerable space and velocity structure is present in the <span class="hlt">Ori</span> OB1a subassociation. The low-mass members follow a well-defined band in the color-magnitude diagram, consistent with an isochronal age of ~7-10 Myr. The ~2 time drop in the overall Li I equivalent widths and accretion fraction between the younger <span class="hlt">Ori</span> OB1b and the 25 <span class="hlt">Ori</span> group is consistent with the latter being significantly older. In a simple-minded kinematic evolution scenario, the 25 <span class="hlt">Ori</span> group may represent the evolved counterpart of the younger ? <span class="hlt">Ori</span> cluster. The 25 <span class="hlt">Ori</span> stellar aggregate is the most populous ~10 Myr sample yet known within 500 pc, setting it as an excellent laboratory to study the evolution of solar-like stars and protoplanetary disks. Based on observations obtained at the Llano del Hato National Astronomical Observatory of Venezuela, operated by CIDA for the Ministerio de Ciencia y Tecnologa the MMT Observatory, a joint facility of the Smithsonian Institution and the University of Arizona; and the Fred Lawrence Whipple Observatory of the Smithsonian Institution.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/3268710','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/3268710"><span id="translatedtitle">[The surgical anatomy of the rectal and anal blood vessels].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Vogel, P; Klosterhalfen, B</p> <p>1988-01-01</p> <p>The authors examined 40 rectum specimens by angiography, preparation and staining methods to show the exact arterial vessel supply of the rectum and tried to find out whether a reason could be found for the relatively high rate of suture leaks after low resection of the rectum or not. The insertion of the <span class="hlt">levator</span> muscle is a sort of vessel divide: caudal to the <span class="hlt">levator</span> muscle the inferior rectal artery is the main supplying vessel, cranially the superior rectal artery. Here a vessel deficient-area always remains in the dorso-caudal sector of the rectal ampulla which cannot be compensated by another rectum-supplying vessel. The middle rectal artery supplies the rectum accessorily. The results are able to explain why the suture leaks are constantly observed in the dorso-caudal ampulla after profound anterior resection of the rectum. Furthermore the results account for the good healing tendency of coloanal anastomoses: the inferior rectal artery amply supplies the anal canal; there is not the same vessel-deficient area as found cranial to the <span class="hlt">levator</span> muscle. PMID:3268710</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23521715','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23521715"><span id="translatedtitle">Distribution pattern of muscle fibre types in soft palate of the dog (Canis familiaris, L.).</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Snchez-Collado, C; Vzquez, J M; Rivero, M A; Martnez, F; Ramrez, G; Gil, F</p> <p>2014-02-01</p> <p>Distribution pattern of fibre types was studied in the muscles of the soft palate (palatinus, <span class="hlt">levator</span> veli palatini and tensor veli palatini muscles) in the dog. The fibrillar classification was based on using histochemistry and immunohistochemistry methods: myofibrillar adenosine thriphosphatase (mATPase) to different pH of pre-incubation; nicotine adenine dinucleotide (reduced) tetrazolium reductase (NADH-TR) and finally, application of specific monoclonal antibodies against myosin heavy chain isoforms I, IIa and IIx. In the palatinus and <span class="hlt">levator</span> veli palatini muscles, pure type I fibres and the hybrid type IIax and IIc were shown, with a checkerboard distribution in the first and a clear predominance of hybrid fibre types (about 98% of the total population) in <span class="hlt">levator</span> veli palatini muscle. On the other hand, in the tensor veli palatini muscle, type IIx and IIm fibres were identified (fast-twitch fibres related to fast-moving muscles and the powerful jaw muscles of carnivores). The tensor veli palatini muscle had a different distribution and fibrillar composition with predominantly type IIm fibres in its central zone, whilst the peripheral zone was primarily type I and IIx fibres. PMID:23521715</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/14582757','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/14582757"><span id="translatedtitle">Reconstruction of microform cleft lip.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tosun, Zekeriya; Ho?nuter, Mbin; Sentrk, Sadik; Savaci, Nedim</p> <p>2003-01-01</p> <p>Partial cleft of the orbicularis <span class="hlt">oris</span> muscle without skin and mucosa can also be called "discontinuity of the orbicularis <span class="hlt">oris</span> muscle" or "subepithelial cleft". Microform cleft lip or mini-cleft lip are better definitions. We present two women aged 25 and 29 years old who complained of vermilion notching, vertical depression on the upper lip, and asymmetry of lower lateral cartilage of the nose. The "discontinuity of the muscle" was found at operation in both cases and reconstructed successfully. PMID:14582757</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1914354','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1914354"><span id="translatedtitle">New criteria for selecting the origin of DNA replication in Wolbachia and closely related bacteria</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ioannidis, Panagiotis; Hotopp, Julie C Dunning; Sapountzis, Panagiotis; Siozios, Stefanos; Tsiamis, Georgios; Bordenstein, Seth R; Baldo, Laura; Werren, John H; Bourtzis, Kostas</p> <p>2007-01-01</p> <p>Background The annotated genomes of two closely related strains of the intracellular bacterium Wolbachia pipientis have been reported without the identifications of the putative origin of replication (<span class="hlt">ori</span>). Identifying the <span class="hlt">ori</span> of these bacteria and related alpha-Proteobacteria as well as their patterns of sequence evolution will aid studies of cell replication and cell density, as well as the potential genetic manipulation of these widespread intracellular bacteria. Results Using features that have been previously experimentally verified in the alpha-Proteobacterium Caulobacter crescentus, the origin of DNA replication (<span class="hlt">ori</span>) regions were identified in silico for Wolbachia strains and eleven other related bacteria belonging to Ehrlichia, Anaplasma, and Rickettsia genera. These features include DnaA-, CtrA- and IHF-binding sites as well as the flanking genes in C. crescentus. The Wolbachia <span class="hlt">ori</span> boundary genes were found to be hemE and COG1253 protein (CBS domain protein). Comparisons of the putative <span class="hlt">ori</span> region among related Wolbachia strains showed higher conservation of bases within binding sites. Conclusion The sequences of the <span class="hlt">ori</span> regions described here are only similar among closely related bacteria while fundamental characteristics like presence of DnaA and IHF binding sites as well as the boundary genes are more widely conserved. The relative paucity of CtrA binding sites in the <span class="hlt">ori</span> regions, as well as the absence of key enzymes associated with DNA replication in the respective genomes, suggest that several of these obligate intracellular bacteria may have altered replication mechanisms. Based on these analyses, criteria are set forth for identifying the <span class="hlt">ori</span> region in genome sequencing projects. PMID:17584494</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2011-02-10/pdf/2011-2975.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2011-02-10/pdf/2011-2975.pdf"><span id="translatedtitle">76 FR 7568 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2011-02-10</p> <p>...Notice is hereby given that the Office of Research Integrity (<span class="hlt">ORI</span>) has taken final action in the following case: Meleik Goodwill, Ph.D., Wadsworth Center, N.Y.S. Department of Health: Based on the Wadsworth Center report and the oversight review conducted by the Office of Research Integrity (<span class="hlt">ORI</span>), the U.S. Public Health Service (PHS) found that Meleik Goodwill, Ph.D., former postdoctoral......</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active"><span>16</span></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_16 --> <div id="page_17" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="321"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/sciencecinema/biblio/1025937','SCIGOVIMAGE-SCICINEMA'); return false;" href="http://www.osti.gov/sciencecinema/biblio/1025937"><span id="translatedtitle">Explorer : des clés pour mieux comprendre la matière</span></a></p> <p><a target="_blank" href="http://www.osti.gov/sciencecinema/">ScienceCinema</a></p> <p>None</p> <p>2011-10-06</p> <p>Le LHC va-t-il bouleverser les thé<span class="hlt">ories</span> de l'infiniment petit ? Les physiciens aimeraient que l'accélérateur fasse trembler le modèle standard. Cette thé<span class="hlt">orie</span> des particules élémentaires et des forces laisse de nombreuses zones d'ombre. Le LHC et ses expériences ont été conçus pour les éclairer.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=19870009742&hterms=White+dwarf+stars&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3D%2528%2528White%2Bdwarf%2529%2Bstars%2529','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=19870009742&hterms=White+dwarf+stars&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3D%2528%2528White%2Bdwarf%2529%2Bstars%2529"><span id="translatedtitle">Stars of type MS with evidence of white dwarf companions. [IUE, Main Sequence (MS)</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Peery, Benjamin F., Jr.</p> <p>1986-01-01</p> <p>A search for white dwarf companions of MS-type stars was conducted, using IUE. The overendowments of these stars in typical S-process nuclides suggest that they, like the Ba II stars, may owe their peculiar compositions to earlier mass transfer. Short-wavelength IUE spectra show striking emission line variability in HD35155, HD61913, and 4 <span class="hlt">Ori</span>; HD35155 and 4 <span class="hlt">Ori</span> show evidence of white dwarf companions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/18179598','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/18179598"><span id="translatedtitle">Escherichia coli DnaA interacts with HU in initiation at the E. coli replication origin.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chodavarapu, Sundari; Felczak, Magdalena M; Yaniv, Josette Rouvire; Kaguni, Jon M</p> <p>2008-02-01</p> <p>Escherichia coli HU protein is a dimer encoded by two closely related genes whose expression is growth phase-dependent. As a major component of the bacterial nucleoid, HU binds to DNA non-specifically, but acts at the chromosomal origin (<span class="hlt">ori</span>C) during initiation by stimulating strand opening in vitro. We show that the alpha dimer of HU is more active than other forms of HU in initiation of an <span class="hlt">ori</span>C-containing plasmid because it more effectively promotes strand opening of <span class="hlt">ori</span>C. Other results demonstrate that HU stabilizes the DnaA oligomer bound to <span class="hlt">ori</span>C, and that the alpha subunit of HU interacts with the N-terminal region of DnaA. These observations support a model whereby DnaA interacts with the alpha dimer or the alphabeta heterodimer, depending on their cellular abundance, to recruit the respective form of HU to <span class="hlt">ori</span>C. The greater activity of the alpha dimer of HU at <span class="hlt">ori</span>C may stimulate initiation during early log phase compared with the lesser activity of the alphabeta heterodimer or the beta dimer. PMID:18179598</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4674748','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4674748"><span id="translatedtitle">Identification of the Replication Origins from Cyanothece ATCC 51142 and Their Interactions with the DnaA Protein: From In Silico to In Vitro Studies</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Huang, He; Song, Cheng-Cheng; Yang, Zhi-Liang; Dong, Yan; Hu, Yao-Zhong; Gao, Feng</p> <p>2015-01-01</p> <p>Based on the complete genome of Cyanothece ATCC 51142, the <span class="hlt">ori</span>Cs of both the circular and linear chromosomes in Cyanothece ATCC 51142 have been predicted by utilizing a web-based system <span class="hlt">Ori</span>-Finder. Here, we provide experimental support for the results of <span class="hlt">Ori</span>-Finder to identify the replication origins of Cyanothece ATCC 51142 and their interactions with the initiator protein, DnaA. The two replication origins are composed of three characteristically arranged DnaA boxes and an AT-rich stretch, and the <span class="hlt">ori</span>C in the circular chromosome is followed by the dnaN gene. The dnaA gene is located downstream of the origin of the circular chromosome and it expresses a typical DnaA protein that is divided into four domains (I, II, III, IV), as with other members of the DnaA protein family. We purify DnaA (IV) and characterize the interaction of the purified protein with the replication origins, so as to offer experimental support for the prediction. The results of the electrophoretic mobility shift assay and DNase I footprint assay demonstrate that the C-terminal domain of the DnaA protein from Cyanothece ATCC 51142 specifically binds the <span class="hlt">ori</span>Cs of both the circular and linear chromosomes, and the DNase I footprint assay demonstrates that DnaA (IV) exhibits hypersensitive affinity with DnaA boxes in both <span class="hlt">ori</span>Cs. PMID:26696980</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/22092251','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/22092251"><span id="translatedtitle">CONSTRAINING MASS RATIO AND EXTINCTION IN THE FU ORIONIS BINARY SYSTEM WITH INFRARED INTEGRAL FIELD SPECTROSCOPY</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Pueyo, Laurent; Hillenbrand, Lynne; Hinkley, Sasha; Dekany, Richard; Roberts, Jenny; Vasisht, Gautam; Roberts, Lewis C. Jr.; Shao, Mike; Burruss, Rick; Cady, Eric; Oppenheimer, Ben R.; Brenner, Douglas; Zimmerman, Neil; Monnier, John D.; Crepp, Justin; Parry, Ian; Beichman, Charles; Soummer, Remi</p> <p>2012-09-20</p> <p>We report low-resolution near-infrared spectroscopic observations of the eruptive star FU Orionis using the Integral Field Spectrograph (IFS) Project 1640 installed at the Palomar Hale telescope. This work focuses on elucidating the nature of the faint source, located 0.''5 south of FU <span class="hlt">Ori</span>, and identified in 2003 as FU <span class="hlt">Ori</span> S. We first use our observations in conjunction with published data to demonstrate that the two stars are indeed physically associated and form a true binary pair. We then proceed to extract J- and H-band spectro-photometry using the damped LOCI algorithm, a reduction method tailored for high contrast science with IFS. This is the first communication reporting the high accuracy of this technique, pioneered by the Project 1640 team, on a faint astronomical source. We use our low-resolution near-infrared spectrum in conjunction with 10.2 {mu}m interferometric data to constrain the infrared excess of FU <span class="hlt">Ori</span> S. We then focus on estimating the bulk physical properties of FU <span class="hlt">Ori</span> S. Our models lead to estimates of an object heavily reddened, A{sub V} = 8-12, with an effective temperature of {approx}4000-6500 K. Finally, we put these results in the context of the FU <span class="hlt">Ori</span> N-S system and argue that our analysis provides evidence that FU <span class="hlt">Ori</span> S might be the more massive component of this binary system.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/22952336','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/22952336"><span id="translatedtitle">Evaluating Maori community initiatives to promote healthy eating, healthy action.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hamerton, Heather; Mercer, Christine; Riini, Denise; McPherson, Brighid; Morrison, Laurie</p> <p>2014-03-01</p> <p>Mā<span class="hlt">ori</span>, the indigenous people of Aotearoa New Zealand, experience poorer health than non-Mā<span class="hlt">ori</span> across a range of health measures. Interventions focused at an individual level have proved largely ineffective; 'bottom-up' approaches where communities determine their own priorities may be more sustainable than 'top-down' approaches where goals are determined by health authorities. The purpose of this paper is to illustrate an innovative health promotion programme aimed at improving Mā<span class="hlt">ori</span> health and to discuss the importance of ownership and control of health initiatives by Mā<span class="hlt">ori</span>. Evaluators conducted a comprehensive evaluation of a Healthy Eating Healthy Action programme in six small Mā<span class="hlt">ori</span> health agencies, gathering information from programme managers and co-ordinators, participants and wider community members about what changes were occurring at individual, family and community levels. Effective interventions built on cultural values and practices and were delivered by Mā<span class="hlt">ori</span> with close connections to the community. Changes in nutrition and physical activity made by participants also benefitted their wider families and community. The changes demonstrated subtle but important shifts in thinking about healthy eating and healthy activity that in the longer term could lead to more measurable change towards improved quality of life for people within communities. PMID:22952336</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26858444','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26858444"><span id="translatedtitle">Ribosome Protein L4 is essential for Epstein-Barr Virus Nuclear Antigen 1 function.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Shen, Chih-Lung; Liu, Cheng-Der; You, Ren-In; Ching, Yung-Hao; Liang, Jun; Ke, Liangru; Chen, Ya-Lin; Chen, Hong-Chi; Hsu, Hao-Jen; Liou, Je-Wen; Kieff, Elliott; Peng, Chih-Wen</p> <p>2016-02-23</p> <p>Epstein-Barr Virus (EBV) Nuclear Antigen 1 (EBNA1)-mediated origin of plasmid replication (<span class="hlt">ori</span>P) DNA episome maintenance is essential for EBV-mediated tumorigenesis. We have now found that EBNA1 binds to Ribosome Protein L4 (RPL4). RPL4 shRNA knockdown decreased EBNA1 activation of an <span class="hlt">ori</span>P luciferase reporter, EBNA1 DNA binding in lymphoblastoid cell lines, and EBV genome number per lymphoblastoid cell line. EBV infection increased RPL4 expression and redistributed RPL4 to cell nuclei. RPL4 and Nucleolin (NCL) were a scaffold for an EBNA1-induced <span class="hlt">ori</span>P complex. The RPL4 N terminus cooperated with NCL-K429 to support EBNA1 and <span class="hlt">ori</span>P-mediated episome binding and maintenance, whereas the NCL C-terminal K380 and K393 induced <span class="hlt">ori</span>P DNA H3K4me2 modification and promoted EBNA1 activation of <span class="hlt">ori</span>P-dependent transcription. These observations provide new insights into the mechanisms by which EBV uses NCL and RPL4 to establish persistent B-lymphoblastoid cell infection. PMID:26858444</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/18040525','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/18040525"><span id="translatedtitle">A role for MRE11, NBS1, and recombination junctions in replication and stable maintenance of EBV episomes.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dheekollu, Jayaraju; Deng, Zhong; Wiedmer, Andreas; Weitzman, Matthew D; Lieberman, Paul M</p> <p>2007-01-01</p> <p>Recombination-like structures formed at origins of DNA replication may contribute to replication fidelity, sister chromatid cohesion, chromosome segregation, and overall genome stability. The Epstein-Barr Virus (EBV) origin of plasmid replication (<span class="hlt">Ori</span>P) provides episomal genome stability through a poorly understood mechanism. We show here that recombinational repair proteins MRE11 and NBS1 are recruited to the Dyad Symmetry (DS) region of <span class="hlt">Ori</span>P in a TRF2- and cell cycle-dependent manner. Depletion of MRE11 or NBS1 by siRNA inhibits <span class="hlt">Ori</span>P replication and destabilized viral episomes. <span class="hlt">Ori</span>P plasmid maintenance was defective in MRE11 and NBS1 hypomorphic fibroblast cell lines and only integrated, non-episomal forms of EBV were detected in a lympoblastoid cell line derived from an NBS1-mutated individual. Two-dimensional agarose gel analysis of <span class="hlt">Ori</span>P DNA revealed that recombination-like structures resembling Holliday-junctions form at <span class="hlt">Ori</span>P in mid S phase. MRE11 and NBS1 association with DS coincided with replication fork pausing and origin activation, which preceded the formation of recombination structures. We propose that NBS1 and MRE11 promote replication-associated recombination junctions essential for EBV episomal maintenance and genome stability. PMID:18040525</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3895524','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3895524"><span id="translatedtitle">Electrophysiologic Investigation During Facial Motor Neuron Suppression in Patients With Hemifacial Spasm: Possible Pathophysiology of Hemifacial Spasm: A Pilot Study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Choi, Soo In; Kim, Min-Wook; Park, Dong Yoon; Huh, Ryoong</p> <p>2013-01-01</p> <p>Objective To evaluate the pathophysiological mechanism of hemifacial spasm (HFS), we performed electrophysiological examinations, such as supraorbital nerve stimulation with orbicularis <span class="hlt">oris</span> muscle recording and lateral spread tests, after suppressing the patient's central nervous system by administering intravenous diazepam. Methods Six patients with HFS were recruited. Supraorbital nerve stimulation with orbicularis <span class="hlt">oris</span> muscle recording and the lateral spread test were performed, followed by intravenous application of 10 mg diazepam to achieve facial motor neuron suppression. Subsequently, we repeated the two electrophysiological experiments mentioned above at 10 and 20 minutes after the patients had received the diazepam intravenously. Results Orbicularis <span class="hlt">oris</span> muscle responses were observed in all patients after supraorbital nerve stimulation and lateral spread tests. After the diazepam injection, no orbicularis <span class="hlt">oris</span> muscle response to supraorbital nerve stimulation was observed in one patient, and the latencies of this response were evident as a slowing tendency with time in the remaining five patients. However, the latencies of the orbicularis <span class="hlt">oris</span> muscle responses were observed consistently in all patients in the lateral spread test. Conclusion Our results suggest that ectopic excitation/ephaptic transmission contributes to the pathophysiological mechanisms of HFS. This is because the latencies of the orbicularis <span class="hlt">oris</span> muscle responses in the lateral spread test were observed consistently in the suppressed motor neuron in our patients. PMID:24466519</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/7145052','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/7145052"><span id="translatedtitle">Octane requirement increase of 1990 and 1991 model vehicles</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Not Available</p> <p>1992-06-01</p> <p>The octane requirement increase (<span class="hlt">ORI</span>) of 80 1990 and 43 1991 model-year vehicles operated on commercial fuels in customer-like service has been determined. These <span class="hlt">ORI</span> values were established from the octane number requirements regardless of whether they were determined at maximum- or part-throttle. At 15,000 miles, the mean <span class="hlt">ORI</span> of the 1990 vehicles with full-boiling range fuels (FBRU) was 4.4 (R+M)/2 octane numbers, 5.2 Research octane numbers (RON), and 3.5 Motor octane numbers (MON). The <span class="hlt">ORI</span> of individual vehicles ranged from no increase to 1 1. 1 (R + M)/2 numbers. At 15,000 miles, the mean <span class="hlt">ORI</span> of the 1991 vehicles with full-boiling range fuels (FBRU) was 3.3 (R+M)/2 numbers, 4.1 RON, and 2.6 MON. Individual vehicle <span class="hlt">ORI</span> ranged from no increase to 9.2 (R + M)/2 numbers. As opposed to a number of 1989 models submitted which showed a somewhat unusual variation with mileage, the 1990 and 1991 models behaved in the more traditional manner.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2016ApJ...816L..29L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2016ApJ...816L..29L"><span id="translatedtitle">Absence of Significant Cool Disks in Young Stellar Objects Exhibiting Repetitive Optical Outbursts</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Liu, Hauyu Baobab; Galván-Madrid, Roberto; Vorobyov, Eduard I.; Kóspál, Ágnes; Rodríguez, Luis F.; Dunham, Michael M.; Hirano, Naomi; Henning, Thomas; Takami, Michihiro; Dong, Ruobing; Hashimoto, Jun; Hasegawa, Yasuhiro; Carrasco-González, Carlos</p> <p>2016-01-01</p> <p>We report Submillimeter Array 1.3 mm high angular resolution observations toward the four EXor-type outbursting young stellar objects VY Tau, V1118 <span class="hlt">Ori</span>, V1143 <span class="hlt">Ori</span>, and NY <span class="hlt">Ori</span>. The data mostly show low dust masses Mdust in the associated circumstellar disks. Among the sources, NY <span class="hlt">Ori</span> possesses a relatively massive disk with Mdust ˜ 9 × 10-4M⊙. V1118 <span class="hlt">Ori</span> has a marginal detection equivalent to Mdust ˜ 6 × 10-5M⊙. V1143 <span class="hlt">Ori</span> has a non-detection also equivalent to Mdust < 6 × 10-5M⊙. For the nearest source, VY Tau, we get a surprising non-detection that provides a stringent upper limit Mdust < 6 × 10-6M⊙. We interpret our findings as suggesting that the gas and dust reservoirs that feed the short-duration, repetitive optical outbursts seen in some EXors may be limited to the small-scale, innermost region of their circumstellar disks. This hot dust may have escaped our detection limits. Follow-up, more sensitive millimeter observations are needed to improve our understanding of the triggering mechanisms of EXor-type outbursts.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2013ApJ...768..122W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2013ApJ...768..122W"><span id="translatedtitle">The Coronal Abundances of Mid-F Dwarfs</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Wood, Brian E.; Laming, J. Martin</p> <p>2013-05-01</p> <p>A Chandra spectrum of the moderately active nearby F6 V star ?3 <span class="hlt">Ori</span> is used to study the coronal properties of mid-F dwarfs. We find that ?3 <span class="hlt">Ori</span>'s coronal emission measure distribution is very similar to those of moderately active G and K dwarfs, with an emission measure peak near log T = 6.6 seeming to be ubiquitous for such stars. In contrast to coronal temperature, coronal abundances are known to depend on spectral type for main sequence stars. Based on this previously known relation, we expected ?3 <span class="hlt">Ori</span>'s corona to exhibit an extremely strong "first ionization potential (FIP) effect," a phenomenon first identified on the Sun where elements with low FIP are enhanced in the corona. We instead find that ?3 <span class="hlt">Ori</span>'s corona exhibits a FIP effect essentially identical to that of the Sun and other early G dwarfs, perhaps indicating that the increase in FIP bias toward earlier spectral types stops or at least slows for F stars. We find that ?3 <span class="hlt">Ori</span>'s coronal characteristics are significantly different from two previously studied mid-F stars, Procyon (F5 IV-V) and ? Boo (F7 V). We believe ?3 <span class="hlt">Ori</span> is more representative of the coronal characteristics of mid-F dwarfs, with Procyon being different because of luminosity class, and ? Boo being different because of the effects of one of two close companions, one stellar (? Boo B: M2 V) and one planetary.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26950459','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26950459"><span id="translatedtitle">Rapid amplification system for recombinant protein production in Chinese Hamster Ovary (CHO) Cells.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Metta, M K; Kunaparaju, R K; Tantravahi, S</p> <p>2016-01-01</p> <p>Recombinant therapeutic proteins have changed the face of modern medicine in the present trend and they continue to provide innovative therapies for deadly diseases. This study describes the development of a novel stable expression system for rapid amplification of genes in Chinese Hamster Ovary (CHO) cells. The expression system consists of a host CHO cell line and an expression vector (pUB-Py<span class="hlt">Ori</span>-D-C) which encodes for Polyomavirus (Py) Origin of Replication (Py<span class="hlt">Ori</span>) for amplification of integrated genes in the presence of Py Large T Antigen (PyLT) and Dihydrofolate Reductase (DHFR) selectable marker gene for selection in the presence of Methotrexate (MTX). Use of both Py<span class="hlt">Ori</span>/PyLT and DHFR can reduce the number of rounds of selection and amplification required for isolation of high producing clones. The efficiency of pUB-Py<span class="hlt">Ori</span>-D-C was compared with that of pUB-D-C plasmid using Green fluorescent protein (GFP) and Erythropoietin (EPO) as reporter proteins. Our results showed that pUB-Py<span class="hlt">Ori</span>-D-C-EPO can help development of high expressing clone in one round of selection/amplification as compared to multiple rounds of selection/amplification with pUB-D-C-EPO plasmid. CHO-DG44/EPO clone generated using pUB-Py<span class="hlt">Ori</span>-D-C-EPO gave a productivity of 119 mg/L in shake flask. PMID:26950459</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015A%26A...574A.118P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015A%26A...574A.118P"><span id="translatedtitle">Characterization of the known T-type dwarfs towards the ? Orionis cluster</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Pea Ramrez, K.; Zapatero Osorio, M. R.; Bjar, V. J. S.</p> <p>2015-02-01</p> <p>Aims: The detailed study of T-type candidate members of the young ? Orionis cluster (~3 Myr, ~352 pc, solar metallicity) is fundamental to properly assess the objects' cluster membership and their contribution to the definition of the substellar mass function. Methods: A total of three T-type candidates (S <span class="hlt">Ori</span> 70, S <span class="hlt">Ori</span> 73, and S <span class="hlt">Ori</span> J053804.65-021352.5) lying in the line of sight towards ? Orionis were characterized by means of near-infrared photometric, astrometric, and spectroscopic studies. H-band methane images were collected for all three sources and an additional sample of 15 field T-type dwarfs using the LIRIS instrument on the 4.2 m William Herschel Telescope (WHT). J-band spectra of resolution of ~500 were obtained for S <span class="hlt">Ori</span> J053804.65-021352.5 with the ISAAC spectrograph on the 8 m Very Large Telescope (VLT), and JH spectra of resolution of ~50 acquired with the Wide Field Camera 3 (WFC3) on board the Hubble Space Telescope (HST) were employed for the spectroscopic classification of S <span class="hlt">Ori</span> 70 and 73. Accurate proper motions with a typical uncertainty of 3 mas yr-1 and a time interval of ~7-9 yr were derived using old images and new data collected with ISAAC/VLT and WFC3/HST. Results: Using the LIRIS observations of the field T dwarfs, we calibrated this imager for T spectral typing via methane photometry. The three S <span class="hlt">Ori</span> objects were spectroscopically classified as T4.5 0.5 (S <span class="hlt">Ori</span> 73), T5 0.5 (S <span class="hlt">Ori</span> J053804.65-021352.5), and T7 +0.5-1.0 (S <span class="hlt">Ori</span> 70). These spectral types agree with the measured H-band methane colors. The similarity between the observed JH spectra and the methane colors and the data of field ultra-cool dwarfs of related classifications suggests that S <span class="hlt">Ori</span> 70, 73, and S <span class="hlt">Ori</span> J053804.65-021352.5 do not deviate significantly in surface gravity in relation to the field. Additionally, the detection of K I at ~1.25 ?m in S <span class="hlt">Ori</span> J053804.65-021352.5 points to a high-gravity atmosphere. Only the K-band reddish nature of S <span class="hlt">Ori</span> 70 may be consistent with a low-gravity atmosphere. The proper motions of S <span class="hlt">Ori</span> 70 and 73 are measurable and are larger than that of the cluster by >3.5?. The proper motion of S <span class="hlt">Ori</span> J053804.65-021352.5 is consistent with a null displacement. These observations suggest that none of the three T dwarfs is a likely ? Orionis member, and that either planetary-mass objects with masses below ~4 MJup may not exist free-floating in the cluster or they may lie at fainter near-infrared magnitudes than those of the targets (i.e., H > 20.6 mag), thus remaining unidentified to date. We determined the volume density of field T4-T7 dwarfs to be ?2.8 1.6 10-3 pc-3 from a survey that covered 2798.4 arcmin2 and was complete up to a distance of 119 pc.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012ISPAr39B5..499S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012ISPAr39B5..499S"><span id="translatedtitle">Generation of High Resolution and High Precision Orthorectified Road Imagery from Mobile Mapping System</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Sakamoto, M.; Tachibana, K.; Shimamura, H.</p> <p>2012-07-01</p> <p>In this paper, a novel technique to generate a high resolution and high precision Orthorectified Road Imagery (<span class="hlt">ORI</span>) by using spatial information acquired from a Mobile Mapping System (MMS) is introduced. The MMS was equipped with multiple sensors such as GPS, IMU, odometer, 2-6 digital cameras and 2-4 laser scanners. In this study, a Triangulated Irregular Network (TIN) based approach, similar to general aerial photogrammetry, was adopted to build a terrain model in order to generate <span class="hlt">ORI</span> with high resolution and high geometric precision. Compared to aerial photogrammetry, there are several issues that are needed to be addressed. <span class="hlt">ORI</span> is generated by merging multiple time sequence images of a short section. Hence, the influence of occlusion due to stationary objects, such as telephone poles, trees, footbridges, or moving objects, such as vehicles, pedestrians are very significant. Moreover, influences of light falloff at the edges of cameras, tone adjustment among images captured from different cameras or a round trip data acquisition of the same path, and time lag between image exposure and laser point acquisition also need to be addressed properly. The proposed method was applied to generate <span class="hlt">ORI</span> with 1 cm resolution, from the actual MMS data sets. The <span class="hlt">ORI</span> generated by the proposed technique was more clear, occlusion free and with higher resolution compared to the conventional orthorectified coloured point cloud imagery. Moreover, the visual interpretation of road features from the <span class="hlt">ORI</span> was much easier. In addition, the experimental results also validated the effectiveness of proposed radiometric corrections. In occluded regions, the <span class="hlt">ORI</span> was compensated by using other images captured from different angles. The validity of the image masking process, in the occluded regions, was also ascertained.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=367143','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=367143"><span id="translatedtitle">Initiation of simian virus 40 DNA replication in vitro: aphidicolin causes accumulation of early-replicating intermediates and allows determination of the initial direction of DNA synthesis.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Decker, R S; Yamaguchi, M; Possenti, R; DePamphilis, M L</p> <p>1986-01-01</p> <p>Aphidicolin, a specific inhibitor of DNA polymerase alpha, provided a novel method for distinguishing between initiation of DNA synthesis at the simian virus 40 (SV40) origin of replication (<span class="hlt">ori</span>) and continuation of replication beyond <span class="hlt">ori</span>. In the presence of sufficient aphidicolin to inhibit total DNA synthesis by 50%, initiation of DNA replication in SV40 chromosomes or <span class="hlt">ori</span>-containing plasmids continued in vitro, whereas DNA synthesis in the bulk of SV40 replicative intermediate DNA (RI) that had initiated replication in vivo was rapidly inhibited. This resulted in accumulation of early RI in which most nascent DNA was localized within a 600- to 700-base-pair region centered at <span class="hlt">ori</span>. Accumulation of early RI was observed only under conditions that permitted initiation of SV40 <span class="hlt">ori</span>-dependent, T-antigen-dependent DNA replication and only when aphidicolin was added to the in vitro system. Increasing aphidicolin concentrations revealed that DNA synthesis in the <span class="hlt">ori</span> region was not completely resistant to aphidicolin but simply less sensitive than DNA synthesis at forks that were farther away. Since DNA synthesized in the presence of aphidicolin was concentrated in the 300 base pairs on the early gene side of <span class="hlt">ori</span>, we conclude that the initial direction of DNA synthesis was the same as that of early mRNA synthesis, consistent with the model proposed by Hay and DePamphilis (Cell 28:767-779, 1982). The data were also consistent with initiation of the first DNA chains in <span class="hlt">ori</span> by CV-1 cell DNA primase-DNA polymerase alpha. Synthesis of pppA/G(pN)6-8(pdN)21-23 chains on a single-stranded DNA template by a purified preparation of this enzyme was completely resistant to aphidicolin, and further incorporation of deoxynucleotide monophosphates was inhibited. Therefore, in the presence of aphidicolin, this enzyme could initiate RNA-primed DNA synthesis at <span class="hlt">ori</span> first in the early gene direction and then in the late gene direction, but could not continue DNA synthesis for an extended distance. Images PMID:3025613</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=53034','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=53034"><span id="translatedtitle">Epstein-Barr nuclear antigen 1 mediates a DNA loop within the latent replication origin of Epstein-Barr virus.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Frappier, L; O'Donnell, M</p> <p>1991-01-01</p> <p>Epstein-Barr virus-encoded nuclear antigen 1 (EBNA-1) binds and activates the viral latent origin of DNA replication, <span class="hlt">ori</span>P. We have used electron microscopy to examine the assembly of EBNA-1 onto <span class="hlt">ori</span>P. The <span class="hlt">ori</span>P region consists of two essential elements separated by approximately 1 kilobase pair of DNA. One element contains 20 tandom EBNA-1 binding sites [called the family of repeats (FR)] and serves to activate initiation of replication at the dyad symmetry (DS) element, which contains 4 EBNA-1 binding sites. Titration of homogeneous EBNA-1 produced in baculovirus (bEBNA-1) onto <span class="hlt">ori</span>P DNA showed an order to the assembly of bEBNA-1 onto <span class="hlt">ori</span>P. At low concentrations, bEBNA-1 was located exclusively on the FR element. As the level of bEBNA-1 was raised, a loop between the FR and DS elements became the most prevalent DNA-protein complex. These data suggest protein-mediated DNA looping may play a role in activating latent-phase replication of the Epstein-Barr virus. Images PMID:1660154</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3976777','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3976777"><span id="translatedtitle">Appetite Response among Those Susceptible or Resistant to Obesity</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Brown, Rachel C.; McLay-Cooke, Rebecca T.; Richardson, Sara L.; Williams, Sheila M.; Grattan, David R.; Chisholm, Alexandra W.-A. H.</p> <p>2014-01-01</p> <p>An alternative approach in determining cause, treatment, and prevention of obesity is to study those who appear resistant to the obesogenic environment. We examined appetite responses in 33 obesity resistant individuals (<span class="hlt">ORI</span>) versus 28 obesity susceptible individuals (OSI). Fingerprick blood samples to measure ghrelin, total peptide YY (PYY), leptin, glucose, and insulin along with appetite ratings were collected at baseline and 15, 30, 60, 120, and 180?min following consumption of a standardized meal. Fasting, area under the curve (AUC), peak/nadir, and time to peak/nadir were compared. Participants completed the three factor eating questionnaire (TFEQ). No significant differences were observed for ghrelin or PYY. Higher leptin concentrations in the OSI disappeared after controlling for percent body fat (%BF). Significant differences in appetite ratings included a lower hunger nadir among OSI compared with <span class="hlt">ORI</span> (P = 0.017). Dietary restraint (P < 0.001) and disinhibition (P < 0.001) were lower in <span class="hlt">ORI</span> compared with OSI, with and without adjustment for %BF. Given the differential body weight of the study groups, similar observed ghrelin concentrations were unexpected, perhaps indicating OSI and <span class="hlt">ORI</span> respond differently to the same ghrelin concentration. Also <span class="hlt">ORI</span> response to hunger appears different as they exhibit lower levels of dietary restraint and disinhibition compared with OSI. PMID:24744781</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015JAVSO..43R.109S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015JAVSO..43R.109S"><span id="translatedtitle">Observational Activities at Manipur University, India (Abstract)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Singh, K. Y.; Meitei, I. A.; Singh, S. A.; Singh, R. B.</p> <p>2015-06-01</p> <p>(Abstract only) We have innovatively designed and constructed three observatories each costing a few hundred USD for housing three small Schmidt-Cassegrain type telescopes namely, Celestron CGE925, Celestron CGE1400, Meade 12-inch LX200GPS. These observatories are completely different in design and are found to be perfectly usable for doing serious work on astronomical observation and measurements. The observatory with the Celestron CGE1400 telescope has been inducted, since January 2012, as one of the observatories of the international Orion Project headquartered at Phoenix, Arizona, which is dedicated for photometric and spectroscopic observations of five bright variable stars of the Orion constellation namely, Betelgeuse (alpha <span class="hlt">Ori</span>), Rigel (beta <span class="hlt">Ori</span>), Mintaka (delta <span class="hlt">Ori</span>), Alnilam (epsilon <span class="hlt">Ori</span>) and Alnitak (zeta <span class="hlt">Ori</span>). Using this observatory, we have been producing BVRI photometric data for the five stars of the Orion project. The other observatory with the Meade 12-inch LX200GPS telescope is being inducted into service for CCD photometric study of SU UMa stars in connection with implementation of a project funded by Indian Space Research Organization (ISRO). In the present paper, we would like to describe our self-built observatories, our observational facilities, the BVRI photometric data that we acquired for the Orion project, and our future plan for observation of variable stars of interest.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/14726243','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/14726243"><span id="translatedtitle">Cell line-specific accumulation of the baculovirus non-hr origin of DNA replication in infected insect cells.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pijlman, Gorben P; Vermeesch, Angela M G; Vlak, Just M</p> <p>2003-11-01</p> <p>Successive viral passage of Spodoptera exigua multicapsid nucleopolyhedrovirus (SeMNPV) in the S. exigua cell line Se301 leads to the rapid accumulation of the non-hr origin of DNA replication (<span class="hlt">ori</span>) as large concatemers. Passage of SeMNPV in two other S. exigua cell lines, SeUCR1 and SeIZD2109, did not show the accumulation of such concatemers. When introduced into SeUCR1 and SeIZD2109 cells, the non-hr <span class="hlt">ori</span> concatemers generated in Se301 cells were maintained but did not increase. This suggests that the non-hr <span class="hlt">ori</span> confers a strong selective advantage in Se301 cells, but not or to a lesser extent in the other cell lines. The cell line-specific accumulation of non-hr <span class="hlt">ori</span> concatemers might be due to a higher intrinsic recombination frequency in Se301 cells and may reflect tissue related differences involving some host cell factor(s). Since non-hr <span class="hlt">ori</span> concatemers in Se301 cells were more abundant in intracellular than in extracellular viral DNA preparations, episomal replication and the requirement of a minimal DNA size for packaging into nucleocapsids is hypothesized. PMID:14726243</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_17 --> <div id="page_18" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="341"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21364800','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21364800"><span id="translatedtitle">Mapping of origin of replication in Themococcales.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ojha, Krishna K; Swati, D</p> <p>2010-01-01</p> <p>Genome replication is a crucial and essential process for the continuity of life.In all organisms it starts at a specific region of the genome known as origin of replication (<span class="hlt">Ori</span>) site. The number of <span class="hlt">Ori</span> sites varies in prokaryotes and eukaryotes. Replication starts at a single <span class="hlt">Ori</span> site in bacteria, but in eukaryotes multiple <span class="hlt">Ori</span> sites are used for fast copying across all chromosomes. The situation becomes complex in archaea, where some groups have single and others have multiple origins of replication. Themococcales, are a hyperthermophilic order of archaea. They are anaerobes and heterotrophs-peptide fermenters, sulphate reducers, methanogens being some of the examples of metabolic types. In this paper we have applied a combination of multiple in silico approaches - Z curve, the cell division cycle (cdc6) gene location and location of consensus origin recognition box (ORB) sequences for location of origin of replication in Thermococcus onnurineus, Thermococcus gammatolerans and other Themococcales and compared the results to that of the well-documented case of Pyrococcus abyssi. The motivation behind this study is to find the number of <span class="hlt">Ori</span> sites based on the data available for members of this order. Results from this in silico analysis show that the Themococcales have a single origin of replication. PMID:21364800</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1994AAS...184.6505J','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1994AAS...184.6505J"><span id="translatedtitle">Observations of Far-uv Absorption Lines at 2 km/s Resolution with IMAPS</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Jenkins, E. B.; Zucchino, P. M.; Reale, M. A.; Joseph, C. L.; Sonneborn, G.; Polidan, R. S.; Williams, T.</p> <p>1994-05-01</p> <p>The Interstellar Medium Absorption Profile Spectrograph (IMAPS) flew on the ORFEUS-Spas mission that was launched on STS-51 in September, 1993 for a joint science program sponsored by the US and German space agencies, NASA and DARA. IMAPS is an objective-grating echelle spectrograph that records the spectra of bright stars in the wavelength region 950-1150 Angstroms at a resolution of 1 to 2 km s(-1) . The central objective of IMAPS is to study the interstellar lines of H_2 and some key atomic species, but it is also useful for observing stellar phenomena. The following stars were observed: gamma Cas, alpha Eri, epsilon <span class="hlt">Ori</span>, zeta <span class="hlt">Ori</span>, kappa <span class="hlt">Ori</span>, zeta Pup, gamma (2) Vel, beta Cru, eta UMa, and beta Cen A. Data processing is still underway, but we present some preliminary results, in particular, well resolved velocity components of H_2 toward epsilon and zeta <span class="hlt">Ori</span>. In zeta <span class="hlt">Ori</span>, H_2 at a heliocentric velocity v_⊙ ~ -2 km s(-1) shows pronounced changes in width for different rotational quantum numbers J, and ionized gas shown by the strong features of C II and N II can be seen over the velocity ranges -95 < v_⊙ < -70 and -45 < v_⊙ < +50 km s(-1) .</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=19820047361&hterms=Orion+Nebula&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3DOrion%2BNebula','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=19820047361&hterms=Orion+Nebula&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D40%26Ntt%3DOrion%2BNebula"><span id="translatedtitle">Ultraviolet absorption by highly ionized atoms in the Orion Nebula</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Franco, J.; Savage, B. D.</p> <p>1982-01-01</p> <p>The International Ultraviolet Explorer was used to obtain high-resolution, far-UV spectra of theta 1 A, theta 1 C, theta 1 D, and theta 2 A Orionis. The interstellar absorption lines in these spectra are discussed with an emphasis on the high-ionization lines of C IV and Si IV. Theta 2 A <span class="hlt">Ori</span> has interstellar C IV and Si IV absorption of moderate strength at the velocity found for normal H II region ions. Theta 1 C <span class="hlt">Ori</span> has very strong interstellar C IV and Si IV absorption at velocities blueshifted by about 25 km/s from that found for the normal H II region ions. The possible origin of the high-ionization lines by three processes is considered: X-ray ionization, collisional ionization, and UV photoionization. It is concluded that the C IV and Si IV ions toward theta 2 A and theta 1 C <span class="hlt">Ori</span> are likely produced by UV photoionization of surrounding nebular gas. In the case of theta 1 C <span class="hlt">Ori</span>, the velocity shift of the high-ionization lines may be produced through the acceleration of high-density globules in the core of the nebula by the stellar wind of theta 1 C <span class="hlt">Ori</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/22239981','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/22239981"><span id="translatedtitle">Two replication regions in the pJM1 virulence plasmid of the marine pathogen Vibrio anguillarum.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Naka, Hiroaki; Chen, Qian; Mitoma, Yasutami; Nakamura, Yusuke; McIntosh-Tolle, Daniel; Gammie, Alison E; Tolmasky, Marcelo E; Crosa, Jorge H</p> <p>2012-03-01</p> <p>Vibrio anguillarum is a fish pathogen that causes vibriosis, a serious hemorrhagic septicemia, in wild and cultured fish. Many serotype O1 strains of this bacterium harbor the 65kb plasmid pJM1 carrying the majority of genes encoding the siderophore anguibactin iron transport system that is one of the most important virulence factors of this bacterium. We previously identified a replication region of the pJM1 plasmid named <span class="hlt">ori</span>1. In this work we determined that <span class="hlt">ori</span>1 can replicate in Escherichia coli and that the chromosome-encoded proteins DnaB, DnaC and DnaG are essential for its replication whereas PolI, IHF and DnaA are not required. The copy number of the pJM1 plasmid is 1-2, albeit cloned smaller fragments of the <span class="hlt">ori</span>1 region replicate with higher copy numbers in V. anguillarum while in E. coli we did not observe an obvious difference of the copy numbers of these constructs which were all high. Furthermore, we were able to delete the <span class="hlt">ori</span>1 region from the pJM1 plasmid and identified a second replication region in pJM1 that we named <span class="hlt">ori</span>2. This second replication region is located on ORF25 that is within the trans-acting factor (TAFr) region, and showed that it can only replicate in V. anguillarum. PMID:22239981</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3319172','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3319172"><span id="translatedtitle">Two replication regions in the pJM1 virulence plasmid of the marine pathogen Vibrio anguillarum</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Naka, Hiroaki; Chen, Qian; Mitoma, Yasutami; Nakamura, Yusuke; McIntosh-Tolle, Daniel; Gammie, Alison E.; Tolmasky, Marcelo E.; Crosa, Jorge H.</p> <p>2012-01-01</p> <p>Vibrio anguillarum is a fish pathogen that causes vibriosis, a serious hemorrhagic septicemia, in wild and cultured fish. Many serotype O1 strains of this bacterium harbor the 65kb plasmid pJM1 carrying the majority of genes encoding the siderophore anguibactin iron transport system that is one of the most important virulence factors of this bacterium. We previously identified a replication region of the pJM1 plasmid named <span class="hlt">ori</span>1. In this work we determined that <span class="hlt">ori</span>1 can replicate in E. coli and that the chromosome-encoded proteins DnaB, DnaC and DnaG are essential for its replication whereas PolI, IHF and DnaA are not required. The copy number of the pJM1 plasmid is 12, albeit cloned smaller fragments of the <span class="hlt">ori</span>1 region replicate with higher copy numbers in V. anguillarum while in E. coli we did not observe an obvious difference of the copy numbers of these constructs which were all high. Furthermore, we were able to delete the <span class="hlt">ori</span>1 region from the pJM1 plasmid and identified a second replication region in pJM1 that we named <span class="hlt">ori</span>2. This second replication region is located on ORF25 that is within the trans-acting factor (TAFr) region, and showed that it can only replicate in V. anguillarum. PMID:22239981</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/21325847','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/21325847"><span id="translatedtitle">{sigma} ORIONIS IRS1 A AND B: A BINARY CONTAINING A PROPLYD</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Hodapp, Klaus W.; Iserlohe, Christof; Krabbe, Alfred; Stecklum, Bringfried</p> <p>2009-08-20</p> <p>We report optical and infrared imaging spectroscopy observations of the young binary object {sigma} Orionis IRS1 A/B. The brighter component ({sigma} <span class="hlt">Ori</span> IRS1 A) of this binary system has M1 spectral type and a mass in the range of {approx} 0.3-0.8 M {sub sun}. The fainter component ({sigma} <span class="hlt">Ori</span> IRS1 B) has a unique morphology and spectrum. The unresolved stellar object is surrounded by an extended envelope that is slightly offset from the position of this star. The envelope's spectrum shows strong emission lines of H and He I but no shock-excited emission from H{sub 2} or [Fe II]. The embedded stellar object {sigma} <span class="hlt">Ori</span> IRS1 B has an absorption spectrum characteristic of a late M photosphere, but with an additional approximately equal amount of dust continuum flux veiling the absorption lines. {sigma} <span class="hlt">Ori</span> IRS1 B is probably a young brown dwarf embedded in a proplyd that is being photoevaporated by the UV flux of the nearby multiple O and B star system {sigma} <span class="hlt">Ori</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3041001','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3041001"><span id="translatedtitle">Mapping of origin of replication in Themococcales</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ojha, Krishna K; Swati, D</p> <p>2010-01-01</p> <p>Genome replication is a crucial and essential process for the continuity of life.In all organisms it starts at a specific region of the genome known as origin of replication (<span class="hlt">Ori</span>) site. The number of <span class="hlt">Ori</span> sites varies in prokaryotes and eukaryotes. Replication starts at a single <span class="hlt">Ori</span> site in bacteria, but in eukaryotes multiple <span class="hlt">Ori</span> sites are used for fast copying across all chromosomes. The situation becomes complex in archaea, where some groups have single and others have multiple origins of replication. Themococcales, are a hyperthermophilic order of archaea. They are anaerobes and heterotrophs-peptide fermenters, sulphate reducers, methanogens being some of the examples of metabolic types. In this paper we have applied a combination of multiple in silico approaches - Z curve, the cell division cycle (cdc6) gene location and location of consensus origin recognition box (ORB) sequences for location of origin of replication in Thermococcus onnurineus, Thermococcus gammatolerans and other Themococcales and compared the results to that of the well-documented case of Pyrococcus abyssi. The motivation behind this study is to find the number of <span class="hlt">Ori</span> sites based on the data available for members of this order. Results from this in silico analysis show that the Themococcales have a single origin of replication. PMID:21364800</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3552951','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3552951"><span id="translatedtitle">Multiple Infections with Cardinium and Two Strains of Wolbachia in The Spider Mite Tetranychus phaselus Ehara: Revealing New Forces Driving the Spread of Wolbachia</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Zhao, Dong-Xiao; Chen, Da-Song; Ge, Cheng; Gotoh, Tetsuo; Hong, Xiao-Yue</p> <p>2013-01-01</p> <p>Cytoplasmic incompatibility (CI) has been proposed as a major mechanism by which certain strains of Wolbachia to invade and persist in host populations. However, mechanisms that underlie the invasion and persistence of non-CI strains are less well understood. Here, we established a spider mite Tetranychus phaselus population multiply infected by Cardinium as well as two distinct lineages of Wolbachia, designated wCon and w<span class="hlt">Ori</span>, to study the forces driving the spread of the non-CI strain of Wolbachia w<span class="hlt">Ori</span>. Interestingly, we found that w<span class="hlt">Ori</span> provided a longevity advantage to its female hosts under ideal conditions, making w<span class="hlt">Ori</span> stay longer in this population, and then being transmitted to more offspring. Furthermore, the lifespan of uninfected females was reduced when mated with multiple-infected males. As a result, the uninfected population is attenuated by the multiple-infected males. Thus, we infer that the host age effects of multiple infection may represent sufficient forces driving the spread of w<span class="hlt">Ori</span> through the host population. PMID:23355904</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26560080','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26560080"><span id="translatedtitle">TcpM: a novel relaxase that mediates transfer of large conjugative plasmids from Clostridium perfringens.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wisniewski, Jessica A; Traore, Daouda A; Bannam, Trudi L; Lyras, Dena; Whisstock, James C; Rood, Julian I</p> <p>2016-03-01</p> <p>Conjugative transfer of toxin and antibiotic resistance plasmids in Clostridium perfringens is mediated by the tcp conjugation locus. Surprisingly, neither a relaxase gene nor an origin of transfer (<span class="hlt">ori</span>T) has been identified on these plasmids, which are typified by the 47?kb tetracycline resistance plasmid pCW3. The tcpM gene (previously called intP) encodes a potential tyrosine recombinase that was postulated to be an atypical relaxase. Mutagenesis and complementation studies showed that TcpM was required for wild-type transfer of pCW3 and that a tyrosine residue, Y259, was essential for TcpM activity, which was consistent with the need for a relaxase-mediated hydrophilic attack at the <span class="hlt">ori</span>T site. Other catalytic residues conserved in tyrosine recombinases were not required for TcpM activity, suggesting that TcpM was not a site-specific recombinase. Mobilization studies led to the identification of the <span class="hlt">ori</span>T site, which was located in the 391?bp intergenic region upstream of tcpM. The <span class="hlt">ori</span>T site was localized to a 150?bp region, and gel mobility shift studies showed that TcpM could bind to this region. Based on these studies we postulate that conjugative transfer of pCW3 involves the atypical relaxase TcpM binding to and processing the <span class="hlt">ori</span>T site to initiate plasmid transfer. PMID:26560080</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/15880740','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/15880740"><span id="translatedtitle">Morphology and evolution of the jaw suspension in lamniform sharks.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wilga, C D</p> <p>2005-07-01</p> <p>The morphology of the jaw suspension and jaw protrusion mechanism in lamniform sharks is described and mapped onto a cladogram to investigate how changes in jaw suspension and protrusion have evolved. This has revealed that several evolutionary modifications in the musculoskeletal apparatus of the jaws have taken place among lamniform sharks. Galeomorph sharks (Carcharhiniformes, Lamniformes, Orectolobiformes, and Heterodontiformes) have paired ethmopalatine ligaments connecting the ethmoid process of the upper jaw to the ethmoid region of the cranium. Basal lamniform sharks also acquired a novel single palatonasal ligament connecting the symphysis of the upper jaw to the cranium mid-ventral to the nasal capsule. Sharks in the family Lamnidae subsequently lost the original paired ethmopalatine ligament while retaining the novel palatonasal ligament. Thus, basal lamniform taxa (Mitsukurina owstoni, Carcharius taurus, Alopias vulpinnis) have increased ligamentous support of the lateral region of the upper jaw while derived species (Lamnidae) have lost this lateral support but gained anterior support. In previous studies the morphology of the jaw suspension has been shown to play a major role in the mechanism of upper jaw protrusion in elasmobranchs. The preorbitalis is the primary muscle effecting upper jaw protrusion in squalean (sister group to galeomorphs) and carcharhiniform (sister group to lamniforms) sharks. The preorbitalis originates from the quadratomandibularis muscle and inserts onto the nasal capsule in squalean and carcharhiniform sharks. Carcharhiniform sharks have evolved a subdivided preorbitalis muscle with the new division inserting near the ethmoid process of the palatoquadrate (upper jaw). Alopid sharks have also independently evolved a partially subdivided preorbitalis with the new division inserting at the base of the ethmoid process and surrounding connective tissue. Lamnid sharks have retained the two preorbitalis divisions but have modified both of the insertion points. The original ventral preorbitalis division now inserts onto the connective tissue surrounding the mid-region of the upper jaw, while the new dorsal preorbitalis division inserts onto the surrounding connective tissue and skin at a more posterior position on the upper jaw. The retractor muscle of the jaws, the <span class="hlt">levator</span> hyomandibularis, has also been modified during the evolution of lamniform sharks. In most sharks, including basal lamniforms, the <span class="hlt">levator</span> hyomandibularis inserts onto the hyomandibula and functions to retract the jaws after protrusion. In alopid and lamnid sharks the <span class="hlt">levator</span> hyomandibularis inserts primarily onto the upper and lower jaws around the jaw joint and is a more direct route for retracting the jaws. Thus, there has been at least one instance of character loss (ethmopalatine ligament), acquisition (palatonasal ligament), subdivision (preorbitalis), and modification (ventral preorbitalis, dorsal preorbitalis, and <span class="hlt">levator</span> hyomandibularis) in the ligaments and muscles associated with the jaw suspension and jaw protrusion mechanism in lamniform sharks. While derived lamniform sharks (Lamna nasus, Carcharodon carcharius, and Isurus oxyrinchus) lost the ancestral passive lateral support of the ethmoid articulation of the upper jaw, they simultaneously acquired muscular support by way of the <span class="hlt">levator</span> hyomandibularis, which provides a dynamic mechanism for lateral support. The evolution of multiple divisions of preorbitalis insertions onto the palatoquadrate and modification of the <span class="hlt">levator</span> hyomandibularis insertion directly onto the jaws provides an active mechanism for multiple protractions and retractions of the upper jaw, which is advantageous in those sharks that gouge or saw pieces from large oversized prey items. PMID:15880740</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/20151364','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/20151364"><span id="translatedtitle">Actions of motor neurons and leg muscles in jumping by planthopper insects (hemiptera, issidae).</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Burrows, Malcolm; Brunig, Peter</p> <p>2010-04-15</p> <p>To understand the catapult mechanism that propels jumping in a planthopper insect, the innervation and action of key muscles were analyzed. The large trochanteral depressor muscle, M133b,c, is innervated by two motor neurons and by two dorsal unpaired median (DUM) neurons, all with axons in N3C. A smaller depressor muscle, M133a, is innervated by two neurons, one with a large-diameter cell body, a large, blind-ending dendrite, and a giant ovoid, axon measuring 50 microm by 30 microm in nerve N5A. The trochanteral <span class="hlt">levator</span> muscles (M132) and (M131) are innervated by N4 and N3B, respectively. The actions of these muscles in a restrained jump were divisible into a three-phase pattern. First, both hind legs were moved into a cocked position by high-frequency bursts of spikes in the <span class="hlt">levator</span> muscles lasting about 0.5 seconds. Second, and once both legs were cocked, M133b,c received a long continuous sequence of motor spikes, but the two <span class="hlt">levators</span> spiked only sporadically. The spikes in the two motor neurons to M133b,c on one side were closely coupled to each other and to the spikes on the other side. If one hind leg was cocked then the spikes only occurred in motor neurons to that side. The final phase was the jump movement itself, which occurred when the depressor spikes ceased and which lasted 1 ms. Muscles 133b,c activated synchronously on both sides, are responsible for generating the power, and M133a and its giant neuron may play a role in triggering the release of a jump. PMID:20151364</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/16813585','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/16813585"><span id="translatedtitle">Magnetic resonance imaging of the low rectum: defining the radiological anatomy.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Salerno, G; Daniels, I R; Brown, G</p> <p>2006-09-01</p> <p>Low rectal cancer provides a particular surgical challenge of local tumour control and sphincter preservation. Histopathological studies have shown that an involved circumferential resection margin (CRM) and depth of extramural invasion are independent markers of poor prognosis and correlate with high local recurrence rates due to residual microscopic disease [1]. Recent data suggests that a CRM at risk of tumour involvement can be reliably seen on the pre-operative magnetic resonance imaging (MRI) scan with good correlation with the histological specimen [2-5]. In published series, low rectal cancers have a higher incidence of involved resection margins, with rates up to 30% for abdomino-perineal excision (APE) vs 10% for low anterior resection (LAR) [6-9]. This has been attributed to narrow surgical planes deep within the pelvis as the mesorectum becomes narrowed and tapered, forming a bare muscle tube at the level of the anal sphincter complex. The challenge for the surgeon is to undertake careful removal of a cylinder of tissue beyond the rectal wall without perforating the tumour. An overall local recurrence rate of 10% after APE for all stages of rectal cancer has been reported and this low rate was attributed to the surgical technique that included a wide peri-anal dissection and lateral division of the <span class="hlt">levator</span> ani. The abdominal dissection was stopped above the tumour, taking care to avoid separation of the tumour from the <span class="hlt">levator</span> ani to reduce the risk of inadvertent tumour cell spillage [8]. Therefore, rates of involved surgical margins from APE specimens may be reduced when a cuff of <span class="hlt">levators</span> is taken compared with standard resection. In this review, we will discuss how MRI of the low rectum can aid in the staging and optimization of the best treatment strategy for low rectal cancer. PMID:16813585</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26581871','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26581871"><span id="translatedtitle">A three-leg model producing tetrapod and tripod coordination patterns of ipsilateral legs in the stick insect.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tóth, T I; Daun-Gruhn, S</p> <p>2016-02-01</p> <p>Insect locomotion requires the precise coordination of the movement of all six legs. Detailed investigations have revealed that the movement of the legs is controlled by local dedicated neuronal networks, which interact to produce walking of the animal. The stick insect is well suited to experimental investigations aimed at understanding the mechanisms of insect locomotion. Beside the experimental approach, models have also been constructed to elucidate those mechanisms. Here, we describe a model that replicates both the tetrapod and tripod coordination pattern of three ipsilateral legs. The model is based on an earlier insect leg model, which includes the three main leg joints, three antagonistic muscle pairs, and their local neuronal control networks. These networks are coupled via angular signals to establish intraleg coordination of the three neuromuscular systems during locomotion. In the present three-leg model, we coupled three such leg models, representing front, middle, and hind leg, in this way. The coupling was between the <span class="hlt">levator</span>-depressor local control networks of the three legs. The model could successfully simulate tetrapod and tripod coordination patterns, as well as the transition between them. The simulations showed that for the interleg coordination during tripod, the position signals of the <span class="hlt">levator</span>-depressor neuromuscular systems sent between the legs were sufficient, while in tetrapod, additional information on the angular velocities in the same system was necessary, and together with the position information also sufficient. We therefore suggest that, during stepping, the connections between the <span class="hlt">levator</span>-depressor neuromuscular systems of the different legs are of primary importance. PMID:26581871</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3303085','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3303085"><span id="translatedtitle">An agonistantagonist cerebellar nuclear system controlling eyelid kinematics during motor learning</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Snchez-Campusano, Raudel; Gruart, Agns; Fernndez-Mas, Rodrigo; Delgado-Garca, Jos M.</p> <p>2012-01-01</p> <p>The presence of two antagonistic groups of deep cerebellar nuclei neurons has been reported as necessary for a proper dynamic control of learned motor responses. Most models of cerebellar function seem to ignore the biomechanical need for a double activationdeactivation system controlling eyelid kinematics, since most of them accept that, for closing the eyelid, only the activation of the orbicularis oculi (OO) muscle (via the red nucleus to the facial motor nucleus) is necessary, without a simultaneous deactivation of <span class="hlt">levator</span> palpebrae motoneurons (via unknown pathways projecting to the perioculomotor area). We have analyzed the kinetic neural commands of two antagonistic types of cerebellar posterior interpositus neuron (IPn) (types A and B), the electromyographic (EMG) activity of the OO muscle, and eyelid kinematic variables in alert behaving cats during classical eyeblink conditioning, using a delay paradigm. We addressed the hypothesis that the interpositus nucleus can be considered an agonistantagonist system controlling eyelid kinematics during motor learning. To carry out a comparative study of the kinetickinematic relationships, we applied timing and dispersion pattern analyses. We concluded that, in accordance with a dominant role of cerebellar circuits for the facilitation of flexor responses, type A neurons fire during active eyelid downward displacementsi.e., during the active contraction of the OO muscle. In contrast, type B neurons present a high tonic rate when the eyelids are wide open, and stop firing during any active downward displacement of the upper eyelid. From a functional point of view, it could be suggested that type B neurons play a facilitative role for the antagonistic action of the <span class="hlt">levator</span> palpebrae muscle. From an anatomical point of view, the possibility that cerebellar nuclear type B neurons project to the perioculomotor areai.e., more or less directly onto <span class="hlt">levator</span> palpebrae motoneuronsis highly appealing. PMID:22435053</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4339521','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4339521"><span id="translatedtitle">Vertical Diplopia and Ptosis from Removal of the Orbital Roof in Pterional Craniotomy</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Desai, Shilpa J.; Lawton, Michael T.; McDermott, Michael W.; Horton, Jonathan C.</p> <p>2014-01-01</p> <p>Purpose To describe a newly recognized clinical syndrome consisting of ptosis, diplopia, vertical gaze limitation, and abduction weakness that can occur following orbital roof removal during orbito-zygomatic-pterional craniotomy. Design Case series. Participants Eight study patients, ages 44 – 80 years, 7 female, with neuro-ophthalmic symptoms after pterional craniotomy. Methods Case description of eight study patients. Main Outcome Measures Presence of ptosis, diplopia, and gaze limitation. Results Eight patients had neuro-ophthalmic findings after pterional craniotomy for meningioma removal or aneurysm clipping. The cardinal features were ptosis, limited elevation and hypotropia. Three patients also had limitation of downgaze and two had limitation of abduction. Imaging showed loss of the fat layers which normally envelop the superior rectus/<span class="hlt">levator</span> palpebrae superioris. The muscles appeared attached to the defect in the orbital roof. Ptosis and diplopia developed in two patients despite Medpor titanium mesh implants. Deficits in all patients showed spontaneous improvement. In two patients a <span class="hlt">levator</span> advancement was required to repair ptosis. In three patients an inferior rectus recession using an adjustable suture was performed to treat vertical diplopia. Follow-up a mean of 6.5 years later revealed that all patients had a slight residual upgaze deficit, but alignment was orthotropic in primary gaze. Conclusions After pterional craniotomy, ptosis, diplopia and vertical gaze limitation can result from tethering of the superior rectus/<span class="hlt">levator</span> palpebrae superioris complex to the surgical defect in the orbital roof. Lateral rectus function is sometimes compromised by muscle attachment to the lateral orbital osteotomy. This syndrome occurs in about 1% of patients after removal of the orbital roof and can be treated, if necessary, by prism glasses or surgery. PMID:25439610</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/16633170','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/16633170"><span id="translatedtitle">Palpebral ptosis: clinical classification, differential diagnosis, and surgical guidelines: an overview.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Clauser, Luigi; Tieghi, Riccardo; Gali, Manlio</p> <p>2006-03-01</p> <p>Palpebral ptosis indicates the abnormal drooping of the upper lid, caused by partial or total reduction in <span class="hlt">levator</span> muscle function. It may be caused by various pathologies, both congenital and acquired. Based on a review of the available literature and on our own clinical experience, a classification is proposed as well as a differential diagnosis between ptosis and pseudoptosis. Some basic surgical guidelines related to age of onset and etiopathogenesis are drawn. Ptosis is divided into neurogenic, myogenic, aponeurotic, and mechanical. The aim of surgery is two fold: functional, to correct the limit in the visual field; and also aesthetic. From January 2000 to January 2004, 42 patients were referred and treated at the Unit of Cranio-Maxillofacial Surgery-Centre for Orbital Pathology and Surgery, Hospital and University, Ferrara, Italy. Of these, 12 cases were congenital and 30 acquired (13 were monolateral and 29 bilateral, for a total of 71 cases). The most widely used surgical techniques were <span class="hlt">levator</span> muscle recession and frontalis suspension. In congenital forms, these techniques were often associated with techniques to correct oculo-muscular imbalance (i.e., strabismus).Seventy-one upper eyelids were treated, 5 of which were mild, 35 moderate, and 31 severe. Regarding <span class="hlt">levator</span> muscle function, 60 were fair and 11 poor.Surgical treatment followed the indications and timing with good morphologic and aesthetic results. Complications included two cases of hypocorrection, two asymmetries, and two cases of hypercorrection. Surgical treatment of palpebral ptosis is complex and requires precise diagnosis and indications for surgery related to clinical examination and pathogenesis. Even if these indications are strictly followed, in some cases, the outcomes are unpredictable. PMID:16633170</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23210500','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23210500"><span id="translatedtitle">Electrical stimulation to the trigeminal proprioceptive fibres that innervate the mechanoreceptors in Mller's muscle induces involuntary reflex contraction of the frontalis muscles.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Matsuo, Kiyoshi; Osada, Yoshiro; Ban, Ryokuya</p> <p>2013-02-01</p> <p>The <span class="hlt">levator</span> and frontalis muscles lack interior muscle spindles, despite consisting of slow-twitch fibres that involuntarily sustain eyelid-opening and eyebrow-raising against gravity. To compensate for this anatomical defect, this study hypothetically proposes that initial voluntary contraction of the <span class="hlt">levator</span> fast-twitch muscle fibres stretches the mechanoreceptors in Mller's muscle and evokes proprioception, which continuously induces reflex contraction of slow-twitch fibres of the <span class="hlt">levator</span> and frontalis muscles. This study sought to determine whether unilateral transcutaneous electrical stimulation to the trigeminal proprioceptive fibres that innervate the mechanoreceptors in Mller's muscle could induce electromyographic responses in the frontalis muscles, with monitoring responses in the orbicularis oculi muscles. The study population included 27 normal subjects and 23 subjects with aponeurotic blepharoptosis, who displayed persistently raised eyebrows on primary gaze and light eyelid closure. The stimulation induced a short-latency response in the ipsilateral frontalis muscle of all subjects and long-latency responses in the bilateral frontalis muscles of normal subjects. However, it did not induce long-latency responses in the bilateral frontalis muscles of subjects with aponeurotic blepharoptosis. The orbicularis oculi muscles showed R1 and/or R2 responses. The stimulation might reach not only the proprioceptive fibres, but also other sensory fibres related to the blink or corneal reflex. The experimental system can provoke a monosynaptic short-latency response in the ipsilateral frontalis muscle, probably through the mesencephalic trigeminal proprioceptive neuron and the frontalis motor neuron, and polysynaptic long-latency responses in the bilateral frontalis muscles through an unknown pathway. The latter neural circuit appeared to be engaged by the circumstances of aponeurotic blepharoptosis. PMID:23210500</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23301687','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23301687"><span id="translatedtitle">Spo0A regulates chromosome copy number during sporulation by directly binding to the origin of replication in Bacillus subtilis.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Boonstra, Mirjam; de Jong, Imke G; Scholefield, Graham; Murray, Heath; Kuipers, Oscar P; Veening, Jan-Willem</p> <p>2013-02-01</p> <p>When starved, Bacillus subtilis cells can enter the developmental programme of endospore formation by activation of the master transcriptional regulator Spo0A. Correct chromosome copy number is crucial for the production of mature and fully resistant spores. The production and maintenance of one chromosome for the mother cell and one copy for the forespore requires accurate co-ordination between DNA replication and initiation of sporulation. Here, we show that Spo0A regulates chromosome copy number by directly binding to a number of Spo0A binding sites that are present near the origin of replication (<span class="hlt">ori</span>C). We demonstrate that cells lacking three specific Spo0A binding sites at <span class="hlt">ori</span>C display increased chromosome copy numbers when sporulation is induced. Our data support the hypothesis that Spo0A directly controls DNA replication during sporulation by binding to <span class="hlt">ori</span>C. PMID:23301687</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21790871','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21790871"><span id="translatedtitle">Globalisation, localisation and implications of a transforming nursing workforce in New Zealand: opportunities and challenges.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Callister, Paul; Badkar, Juthika; Didham, Robert</p> <p>2011-09-01</p> <p>Severe staff and skill shortages within the health systems of developed countries have contributed to increased migration by health professionals. New Zealand stands out among countries in the Organisation for Economic Co-operation and Development in terms of the high level of movements in and out of the country of skilled professionals, including nurses. In New Zealand, much attention has been given to increasing the number of M?<span class="hlt">ori</span> and Pacific nurses as one mechanism for improving M?<span class="hlt">ori</span> and Pacific health. Against a backdrop of the changing characteristics of the New Zealand nursing workforce, this study demonstrates that the globalisation of the nursing workforce is increasing at a faster rate than its localisation (as measured by the growth of the M?<span class="hlt">ori</span> and New Zealand-born Pacific workforces in New Zealand). This challenges the implementation of culturally appropriate nursing programmes based on the matching of nurse and client ethnicities. PMID:21790871</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=19800026527&hterms=copernicus&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dcopernicus','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=19800026527&hterms=copernicus&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dcopernicus"><span id="translatedtitle">Copernicus observations of interstellar matter toward the Orion OB1 association. I - Epsilon and Pi-5 Orionis</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Shull, J. M.</p> <p>1979-01-01</p> <p>Copernicus UV data on interstellar lines toward Epsilon <span class="hlt">Ori</span> and Pi-5 <span class="hlt">Ori</span> are analyzed to study abundances and physical conditions in both low- and intermediate-velocity components. Clouds at -8 and +5 km/s (LSR) toward Epsilon <span class="hlt">Ori</span> show typical depletions of Fe, Ti, Mg, and Si in dense (H number density about 100 per cu cm) gas. Low-column-density intermediate-velocity clouds toward both stars, with low densities (hydrogen number density less than 1 per cu cm) and near-cosmic Si abundances, are consistent with a widespread pattern of high-velocity gas over a 15-deg area surrounding the Orion region. Such activity may be attributed to the repeated action of supernovae in a patchy low-density region of interstellar gas.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_18 --> <div id="page_19" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="361"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2628580','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2628580"><span id="translatedtitle">The Importance of Odorant Conformation to the Binding and Activation of a Representative Olfactory Receptor</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Peterlin, Zita; Li, Yadi; Sun, Guangxing; Shah, Rohan; Firestein, Stuart; Ryan, Kevin</p> <p>2008-01-01</p> <p>SUMMARY Olfactory receptors (ORs) form a large family of G-protein coupled receptor proteins (GPCRs) responsible for sensing the ambient chemical environment. The molecular recognition strategies used by ORs to detect and distinguish odorant molecules are unclear. Here, we investigated the variable of odorant carbon chain conformation for an established odorant-OR pair: n-octanal and rat <span class="hlt">OR-I</span>7. A series of conformationally restricted octanal mimics were tested on live olfactory sensory neurons (OSNs). Our results support a model in which unactivated <span class="hlt">OR-I</span>7 binds aliphatic aldehydes indiscriminately, and then applies conformational and length filters to distinguish agonists from antagonists. Specific conformers are proposed to activate <span class="hlt">OR-I</span>7 by steric buttressing of an OR activation pocket. Probing endogenously expressed rat OSNs with octanal and constrained mimics furnished evidence that odorant conformation contributes to an odorants unique olfactory code signature. PMID:19101476</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26141047','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26141047"><span id="translatedtitle">Support Needs of Families Living with Children with Autism Spectrum Disorder.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Searing, Billie Margaret Jean; Graham, Fiona; Grainger, Rebecca</p> <p>2015-11-01</p> <p>This study examined the perceived availability and helpfulness of supports used by caregivers of children with Autism Spectrum Disorder in New Zealand, particularly for caregivers who are Mā<span class="hlt">ori</span>, and who live rurally. Caregivers (N = 92) completed the Family Support Scale with comparisons analysed using t tests. Free text comments were invited and analysed using a general inductive approach. More support was perceived as available by Non-Mā<span class="hlt">ori</span> than Mā<span class="hlt">ori</span> p = 0.03, 95 % CI (0.21, 3.88). Spouses were rated as the most helpful support. Professional helpers were rated as 'somewhat helpful'. Helpful support emphasised caring, knowledge and accessibility. Ethnic differences in perceptions of support endorse calls for culturally tailored supports. Informal supports are highly valued however professional supports require development to better meet caregiver needs. PMID:26141047</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=556933','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=556933"><span id="translatedtitle">DNA damage-inducible origins of DNA replication in Escherichia coli.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Magee, T R; Asai, T; Malka, D; Kogoma, T</p> <p>1992-01-01</p> <p>Upon induction of the SOS response in Escherichia coli, the mode of initiation of DNA replication is altered such that it can occur in the absence of normally required protein synthesis. This type of DNA replication has been termed induced stable DNA replication (iSDR). We examined the origin usage during iSDR and found that the initiation of iSDR occurs primarily in the <span class="hlt">ori</span>C and terC regions of the chromosome in a manner completely independent of transcription, translation and DnaA protein. Minichromosomes (<span class="hlt">ori</span>C plasmids) pOC23 and pOC81 were induced to replicate in the absence of DnaA protein and transcription after SOS induction. The results localized one of the iSDR origin activities in a 596 bp region which includes the minimal <span class="hlt">ori</span>C. Images PMID:1396602</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=19750048033&hterms=cloud+computing&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Dcloud%2Bcomputing','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=19750048033&hterms=cloud+computing&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Dcloud%2Bcomputing"><span id="translatedtitle">Interstellar clouds containing optically thin H2</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Jura, M.</p> <p>1975-01-01</p> <p>The theory of Black and Delgarno that the relative populations of the excited rotational levels of H2 can be understood in terms of cascading following absorption in the Lyman and Werner bands is employed to infer the gas densities and radiation fields within diffuse interstellar clouds containing H2 that is optically thin in those bands. The procedure is described for computing the populations of the different rotation levels, the relative distribution among the different rotation levels of newly formed H2 is determined on the basis of five simplified models, and the rate of H2 formation is estimated. The results are applied to delta <span class="hlt">Ori</span>, two components of iota <span class="hlt">Ori</span>, the second components of rho Leo and zeta <span class="hlt">Ori</span>, tau Sco, gamma Vel, and zeta Pup. The inferred parameters are summarized for each cloud.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25625336','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25625336"><span id="translatedtitle">Forceps: towards obsolescence or revival?</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dietz, Hans Peter</p> <p>2015-04-01</p> <p>Cesarean section rates have become a political issue, attracting the attention of governments, health bureaucrats and professional organizations. In some instances this has led to a renewed interest in forceps delivery, even Kielland's rotational forceps. It is suggested that calls for a greater use of forceps, especially rotational forceps, are ill-advised and commonly based on ignorance of recent urogynecological and imaging literature. Forceps use is associated with a much higher likelihood of major maternal trauma, especially to the anal sphincter and <span class="hlt">levator</span> ani muscles, which may result in substantial future morbidity. Hence, its use should be avoided whenever possible. This is particularly obvious for rotational forceps. PMID:25625336</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3519132','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3519132"><span id="translatedtitle">Surgically Mismanaged Ptosis in a Patient with Congenital Fibrosis of the Extraocular Muscles Type I</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Tawfik, Hatem A.; Rashad, Mohamed A.</p> <p>2012-01-01</p> <p>Fibrosis syndromes comprise a rare form of severe limitation of ocular motility. An 11-year-old girl was referred for the correction of eyelid retraction. The eyelid retraction occurred immediately following <span class="hlt">levator</span> resection surgery performed by a plastic surgeon who missed the restrictive extraocular muscle abnormalities. On examination, both eyes were fixed in an infraducted position (20 prism diopters (?)), with a chin-up position and significant lagophthalmos. Bilateral 12-mm inferior rectus recession with adjustable sutures was performed, which resulted in significant reduction of lagophthalmos and elimination of the head tilt. PMID:23248547</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4339506','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4339506"><span id="translatedtitle">Unattractive infant faces elicit negative affect from adults</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Schein, Stevie S.; Langlois, Judith H.</p> <p>2015-01-01</p> <p>We examined the relationship between infant attractiveness and adult affect by investigating whether differing levels of infant facial attractiveness elicit facial muscle movement correlated with positive and negative affect from adults (N = 87) using electromyography. Unattractive infant faces evoked significantly more corrugator supercilii and <span class="hlt">levator</span> labii superioris movement (physiological correlates of negative affect) than attractive infant faces. These results suggest that unattractive infants may be at risk for negative affective responses from adults, though the relationship between those responses and caregiving behavior remains elusive. PMID:25658199</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25724960','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25724960"><span id="translatedtitle">A replicative plasmid vector allows efficient complementation of pathogenic Leptospira strains.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pappas, Christopher J; Benaroudj, Nadia; Picardeau, Mathieu</p> <p>2015-05-01</p> <p>Leptospirosis, an emerging zoonotic disease, remains poorly understood because of a lack of genetic manipulation tools available for pathogenic leptospires. Current genetic manipulation techniques include insertion of DNA by random transposon mutagenesis and homologous recombination via suicide vectors. This study describes the construction of a shuttle vector, pMa<span class="hlt">ORI</span>, that replicates within saprophytic, intermediate, and pathogenic leptospires. The shuttle vector was constructed by the insertion of a 2.9-kb DNA segment including the parA, parB, and rep genes into pMAT, a plasmid that cannot replicate in Leptospira spp. and contains a backbone consisting of an aadA cassette, <span class="hlt">ori</span> R6K, and <span class="hlt">ori</span>T RK2/RP4. The inserted DNA segment was isolated from a 52-kb region within Leptospira mayottensis strain 200901116 that is not found in the closely related strain L. mayottensis 200901122. Because of the size of this region and the presence of bacteriophage-like proteins, it is possible that this region is a result of a phage-related genomic island. The stability of the pMa<span class="hlt">ORI</span> plasmid within pathogenic strains was tested by passaging cultures 10 times without selection and confirming the presence of pMa<span class="hlt">ORI</span>. Concordantly, we report the use of trans complementation in the pathogen Leptospira interrogans. Transformation of a pMa<span class="hlt">ORI</span> vector carrying a functional copy of the perR gene in a null mutant background restores the expression of PerR and susceptibility to hydrogen peroxide comparable to that of wild-type cells. In conclusion, we demonstrate the replication of a stable plasmid vector in a large panel of Leptospira strains, including pathogens. The shuttle vector described will expand our ability to perform genetic manipulation of Leptospira spp. PMID:25724960</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4393447','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4393447"><span id="translatedtitle">A Replicative Plasmid Vector Allows Efficient Complementation of Pathogenic Leptospira Strains</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pappas, Christopher J.; Benaroudj, Nadia</p> <p>2015-01-01</p> <p>Leptospirosis, an emerging zoonotic disease, remains poorly understood because of a lack of genetic manipulation tools available for pathogenic leptospires. Current genetic manipulation techniques include insertion of DNA by random transposon mutagenesis and homologous recombination via suicide vectors. This study describes the construction of a shuttle vector, pMa<span class="hlt">ORI</span>, that replicates within saprophytic, intermediate, and pathogenic leptospires. The shuttle vector was constructed by the insertion of a 2.9-kb DNA segment including the parA, parB, and rep genes into pMAT, a plasmid that cannot replicate in Leptospira spp. and contains a backbone consisting of an aadA cassette, <span class="hlt">ori</span> R6K, and <span class="hlt">ori</span>T RK2/RP4. The inserted DNA segment was isolated from a 52-kb region within Leptospira mayottensis strain 200901116 that is not found in the closely related strain L. mayottensis 200901122. Because of the size of this region and the presence of bacteriophage-like proteins, it is possible that this region is a result of a phage-related genomic island. The stability of the pMa<span class="hlt">ORI</span> plasmid within pathogenic strains was tested by passaging cultures 10 times without selection and confirming the presence of pMa<span class="hlt">ORI</span>. Concordantly, we report the use of trans complementation in the pathogen Leptospira interrogans. Transformation of a pMa<span class="hlt">ORI</span> vector carrying a functional copy of the perR gene in a null mutant background restores the expression of PerR and susceptibility to hydrogen peroxide comparable to that of wild-type cells. In conclusion, we demonstrate the replication of a stable plasmid vector in a large panel of Leptospira strains, including pathogens. The shuttle vector described will expand our ability to perform genetic manipulation of Leptospira spp. PMID:25724960</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23179462','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23179462"><span id="translatedtitle">Micronucleation by mitosis inhibitors in developing microspores of Spathiphyllum wallisii Regel.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lakshmanan, P S; Eeckhaut, T; Van Huylenbroeck, J; Van Bockstaele, E</p> <p>2013-03-01</p> <p>KEY MESSAGE : We developed an efficient protocol for chromosome scattering in Spathiphyllum microspores. The effects of plant material, developmental age, genotype and antimicrotubular toxin type, exposure and concentration were evaluated. Asymmetric hybridization through microprotoplast-mediated chromosome transfer (MMCT) is a known method for overcoming sexual breeding barriers between distantly related plant species. To obtain microprotoplasts, it is necessary to induce mass micronucleation either in somatic or gametic cells. We have tested the efficiency for micronuclei induction of five mitosis inhibitors, amiprophos-methyl (APM), butamiphos (BUT), chlorpropham (CIPC), oryzalin (<span class="hlt">ORY</span>) and propyzamide (PRO), on developing microspores of diploid Spathiphyllum wallisii Regel. Besides the used toxins, also the effect of their concentrations and incubation period as well as plant genotypes and material was tested. We observed micronuclei (MNi) in pollen mother cells, dyads and tetrads as well as other abnormalities such as ball metaphases and chromosome bridges. The flower position on the spadix and the type of starting material (dissected anthers vs. complete spadices) did not significantly influence micronucleation frequencies. The highest micronucleation index of 86% was obtained in microspores treated with 10?M <span class="hlt">ORY</span> during 72h. All six genotypes tested formed micronuclei after this particular treatment, although the efficiency varied between cultivars. Next to <span class="hlt">ORY</span>, CIPC was also a very efficient MNi inducer. The average number of MNi found in micronucleated cells varied between 1.67-6.44 for CIPC and 0.83-5.50 for <span class="hlt">ORY</span>. The maximal number of MNi observed was 12 for CIPC and 9 for <span class="hlt">ORY</span>. Our results demonstrate that CIPC and <span class="hlt">ORY</span> can be applied for mass micronucleation on developing microspores of S. wallisii as a first step of MMCT in aroid interspecific or intergeneric breeding. PMID:23179462</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4099155','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4099155"><span id="translatedtitle">The WERO group stop smoking competition: main outcomes of a pre- and post- study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2014-01-01</p> <p>Background One potential promising strategy for increasing smoking cessation for M?<span class="hlt">ori</span> (Indigenous New Zealanders) and New Zealand resident Pacific Island people is Quit and Win competitions. The current uncontrolled pre and post study, WERO (WERO in M?<span class="hlt">ori</span> language means challenge), differs from previous studies in that it aims to investigate if a stop smoking contest, using both within team support, external support from a team coach and cessation experts, and technology, would be effective in prompting and sustaining quitting. Method Fifteen teams, recruited from urban M?<span class="hlt">ori</span>, rural M?<span class="hlt">ori</span> and urban Pacific communities, competed to win a NZ$5000 (about 3,000, 2600) prize for a charity or community group of their choice. People were eligible if they were aged 18years and over and identified as smokers. Smoking status was biochemically validated at the start and end of the 3month competition. At 3-months post competition self-reported smoking status was collected. Results Fourteen teams with 10 contestants and one team with eight contestants were recruited. At the end of the competition the biochemically verified quit rate was 36%. The 6 months self-reported quit rate was 26%. The Pacific and rural M?<span class="hlt">ori</span> teams had high end of competition and 6 months follow-up quit rates (46% and 44%, and 36% and 29%). Conclusion WERO appeared to be successful in prompting quitting among high smoking prevalence groups. WERO combined several promising strategies for supporting cessation: peer support, cessation provider support, incentives, competition and interactive internet and mobile tools. Though designed for M?<span class="hlt">ori</span> and Pacific people, WERO could potentially be effective for other family- and community-centred cultures. PMID:24924780</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4652767','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4652767"><span id="translatedtitle">Origin-of-transfer sequences facilitate mobilisation of non-conjugative antimicrobial-resistance plasmids in Staphylococcus aureus</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>O'Brien, Frances G.; Yui Eto, Karina; Murphy, Riley J. T.; Fairhurst, Heather M.; Coombs, Geoffrey W.; Grubb, Warren B.; Ramsay, Joshua P.</p> <p>2015-01-01</p> <p>Staphylococcus aureus is a common cause of hospital, community and livestock-associated infections and is increasingly resistant to multiple antimicrobials. A significant proportion of antimicrobial-resistance genes are plasmid-borne, but only a minority of S. aureus plasmids encode proteins required for conjugative transfer or Mob relaxase proteins required for mobilisation. The pWBG749 family of S. aureus conjugative plasmids can facilitate the horizontal transfer of diverse antimicrobial-resistance plasmids that lack Mob genes. Here we reveal that these mobilisable plasmids carry copies of the pWBG749 origin-of-transfer (<span class="hlt">ori</span>T) sequence and that these <span class="hlt">ori</span>T sequences facilitate mobilisation by pWBG749. Sequences resembling the pWBG749 <span class="hlt">ori</span>T were identified on half of all sequenced S. aureus plasmids, including the most prevalent large antimicrobial-resistance/virulence-gene plasmids, pIB485, pMW2 and pUSA300HOUMR. <span class="hlt">ori</span>T sequences formed five subfamilies with distinct inverted-repeat-2 (IR2) sequences. pWBG749-family plasmids encoding each IR2 were identified and pWBG749 mobilisation was found to be specific for plasmids carrying matching IR2 sequences. Specificity of mobilisation was conferred by a putative ribbon-helix-helix-protein gene smpO. Several plasmids carried 2–3 <span class="hlt">ori</span>T variants and pWBG749-mediated recombination occurred between distinct <span class="hlt">ori</span>T sites during mobilisation. These observations suggest this relaxase-in trans mechanism of mobilisation by pWBG749-family plasmids is a common mechanism of plasmid dissemination in S. aureus. PMID:26243776</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26243776','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26243776"><span id="translatedtitle">Origin-of-transfer sequences facilitate mobilisation of non-conjugative antimicrobial-resistance plasmids in Staphylococcus aureus.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>O'Brien, Frances G; Yui Eto, Karina; Murphy, Riley J T; Fairhurst, Heather M; Coombs, Geoffrey W; Grubb, Warren B; Ramsay, Joshua P</p> <p>2015-09-18</p> <p>Staphylococcus aureus is a common cause of hospital, community and livestock-associated infections and is increasingly resistant to multiple antimicrobials. A significant proportion of antimicrobial-resistance genes are plasmid-borne, but only a minority of S. aureus plasmids encode proteins required for conjugative transfer or Mob relaxase proteins required for mobilisation. The pWBG749 family of S. aureus conjugative plasmids can facilitate the horizontal transfer of diverse antimicrobial-resistance plasmids that lack Mob genes. Here we reveal that these mobilisable plasmids carry copies of the pWBG749 origin-of-transfer (<span class="hlt">ori</span>T) sequence and that these <span class="hlt">ori</span>T sequences facilitate mobilisation by pWBG749. Sequences resembling the pWBG749 <span class="hlt">ori</span>T were identified on half of all sequenced S. aureus plasmids, including the most prevalent large antimicrobial-resistance/virulence-gene plasmids, pIB485, pMW2 and pUSA300HOUMR. <span class="hlt">ori</span>T sequences formed five subfamilies with distinct inverted-repeat-2 (IR2) sequences. pWBG749-family plasmids encoding each IR2 were identified and pWBG749 mobilisation was found to be specific for plasmids carrying matching IR2 sequences. Specificity of mobilisation was conferred by a putative ribbon-helix-helix-protein gene smpO. Several plasmids carried 2-3 <span class="hlt">ori</span>T variants and pWBG749-mediated recombination occurred between distinct <span class="hlt">ori</span>T sites during mobilisation. These observations suggest this relaxase-in trans mechanism of mobilisation by pWBG749-family plasmids is a common mechanism of plasmid dissemination in S. aureus. PMID:26243776</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3788811','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3788811"><span id="translatedtitle">Food Prices and Consumer Demand: Differences across Income Levels and Ethnic Groups</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ni Mhurchu, Cliona; Eyles, Helen; Schilling, Chris; Yang, Qing; Kaye-Blake, William; Genç, Murat; Blakely, Tony</p> <p>2013-01-01</p> <p>Background Targeted food pricing policies may improve population diets. To assess their effects on inequalities, it is important to determine responsiveness to price changes across income levels and ethnic groups. Objective Our goal was to estimate price elasticity (PE) values for major commonly consumed food groups in New Zealand, by income and ethnicity. PE values represent percentage change in demand associated with 1% change in price of that good (own-PE) or another good (cross-PE). Design We used food expenditure data from national household economic surveys in 2007/08 and 2009/10 and Food Price Index data from 2007 and 2010. Adopting an Almost Ideal Demand System approach, own-PE and cross-PE estimates were derived for 24 food categories, household income quintiles, and two ethnic groups (Mā<span class="hlt">ori</span> and non-Mā<span class="hlt">ori</span>). Results Own-PE estimates (with two exceptions) ranged from −0.44 to −1.78. Cross-PE estimates were generally small; only 31% of absolute values were greater than 0.10. Excluding the outlier ‘energy drinks’, nine of 23 food groups had significantly stronger own-PEs for the lowest versus highest income quintiles (average regression-based difference across food groups −0.30 (95% CI −0.62 to 0.02)). Six own-PEs were significantly stronger among Mā<span class="hlt">ori</span>; the average difference for Mā<span class="hlt">ori</span>: non-Mā<span class="hlt">ori</span> across food groups was −0.26 (95% CI −0.52 to 0.00). Conclusions Food pricing policies have potential to improve population diets. The greater sensitivity of low-income households and Mā<span class="hlt">ori</span> to price changes suggests the beneficial effects of such policies on health would be greatest for these groups. PMID:24098408</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/5017566','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/5017566"><span id="translatedtitle">Ultraviolet absorption by highly ionized atoms in the Orion nebula</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Franco, J.; Savage, B.D.</p> <p>1982-04-15</p> <p>The International Ultraviolet Explorer was used to obtain high-resolution, far-UV spectra of theta/sup 1/A, theta/sup 1/C, theta/sup 1/D, and theta/sup 2/A Orionis. The interstellar absorption lines in these spectra are discussed with an emphasis on the high-resolution lines of C IV and Si IV. Toward theta/sup 1/A and theta/sup 1/D <span class="hlt">Ori</span>, blending of interstellar and stellar absorption prevents us from unambiguously determining the strength of the high-ionization interstellar absorption. theta/sup 2/A <span class="hlt">Ori</span> has an interstellar C IV and Si IV absorption of moderate strength at the velocity found for normal H II region ions. theta/sup 1/C <span class="hlt">Ori</span> has very strong interstellar C IV and Si IV absorption at velocities blueshifted by approx.25 km s/sup -1/ from that found for the normal H II region ions. We consider the possible origin of the high-ionization lines by three processes: X-ray ionization, collisional ionization, and UV photoionization. We conclude that the C IV and Si IV ions toward theta/sup 2/A and theta/sup 1/C <span class="hlt">Ori</span> are likely produced by UV photoionization of surrounding nebular gas. In the case of theta/sup 1/C <span class="hlt">Ori</span>, the velocity shift of the high-ionization lines may be produced through the acceleration of high-density globules in the core of the nebula by the stellar wind of theta/sup 1/C <span class="hlt">Ori</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/22126756','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/22126756"><span id="translatedtitle">THE CORONAL ABUNDANCES OF MID-F DWARFS</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Wood, Brian E.; Laming, J. Martin</p> <p>2013-05-10</p> <p>A Chandra spectrum of the moderately active nearby F6 V star {pi}{sup 3} <span class="hlt">Ori</span> is used to study the coronal properties of mid-F dwarfs. We find that {pi}{sup 3} <span class="hlt">Ori</span>'s coronal emission measure distribution is very similar to those of moderately active G and K dwarfs, with an emission measure peak near log T = 6.6 seeming to be ubiquitous for such stars. In contrast to coronal temperature, coronal abundances are known to depend on spectral type for main sequence stars. Based on this previously known relation, we expected {pi}{sup 3} <span class="hlt">Ori</span>'s corona to exhibit an extremely strong ''first ionization potential (FIP) effect'', a phenomenon first identified on the Sun where elements with low FIP are enhanced in the corona. We instead find that {pi}{sup 3} <span class="hlt">Ori</span>'s corona exhibits a FIP effect essentially identical to that of the Sun and other early G dwarfs, perhaps indicating that the increase in FIP bias toward earlier spectral types stops or at least slows for F stars. We find that {pi}{sup 3} <span class="hlt">Ori</span>'s coronal characteristics are significantly different from two previously studied mid-F stars, Procyon (F5 IV-V) and {tau} Boo (F7 V). We believe {pi}{sup 3} <span class="hlt">Ori</span> is more representative of the coronal characteristics of mid-F dwarfs, with Procyon being different because of luminosity class, and {tau} Boo being different because of the effects of one of two close companions, one stellar ({tau} Boo B: M2 V) and one planetary.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4497933','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4497933"><span id="translatedtitle">Physical well-being and ethnic inequality in New Zealand prisons, 1840–1975</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Inwood, Kris; Oxley, Les</p> <p>2015-01-01</p> <p>The British colonization of New Zealand after 1840 was marked by an unusual concern compared to other settler colonies for incorporating the indigenous population Mā<span class="hlt">ori</span> population into the new society. But despite a continuing political rhetoric of protection and sovereignty Mā<span class="hlt">ori</span> have historically had lower living standards and, since the 1920s, higher rates of incarceration than European-descended New Zealanders (Pākehā). In this paper we examine differences between Mā<span class="hlt">ori</span> and Pākehā over 130 years using prison records. Aggregate data from the Ministry of Justice show long-term change and differences in incarceration rates. Using a dataset of all extant registers of men entering New Zealand prisons we show change over time in convictions and in height. The adult statures of Mā<span class="hlt">ori</span> and Pākehā were similar for men born before 1900 but marked differences emerged among cohorts born during the twentieth century. By World War II the gap in adult stature widened to around 3 cm, before narrowing for men born after World War II. Periods of divergence in stature are paralleled by divergence in fertility and indicators of family size, suggesting the possibility that increasing fertility stressed the economic situation of Mā<span class="hlt">ori</span> families. The prison evidence suggests that inequalities in ‘net nutrition’ between Mā<span class="hlt">ori</span> and Pākehā are long-standing but not unchanging, indeed they increased for cohorts born into the early 20th century. A subset of the data describing adolescents confirms that among those born after 1945 the ethnic differential was already visible by the age of 16 years. PMID:26167110</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25697222','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25697222"><span id="translatedtitle">Direct single-molecule observations of local denaturation of a DNA double helix under a negative supercoil state.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Takahashi, Shunsuke; Motooka, Shinya; Usui, Tomohiro; Kawasaki, Shohei; Miyata, Hidefumi; Kurita, Hirofumi; Mizuno, Takeshi; Matsuura, Shun-ichi; Mizuno, Akira; Oshige, Masahiko; Katsura, Shinji</p> <p>2015-03-17</p> <p>Effects of a negative supercoil on the local denaturation of the DNA double helix were studied at the single-molecule level. The local denaturation in λDNA and λDNA containing the SV40 origin of DNA replication (SV40<span class="hlt">ori</span>-λDNA) was directly observed by staining single-stranded DNA regions with a fusion protein comprising the ssDNA binding domain of a 70-kDa subunit of replication protein A and an enhanced yellow fluorescent protein (RPA-YFP) followed by staining the double-stranded DNA regions with YOYO-1. The local denaturation of λDNA and SV40<span class="hlt">ori</span>-λDNA under a negative supercoil state was observed as single bright spots at the single-stranded regions. When negative supercoil densities were gradually increased to 0, -0.045, and -0.095 for λDNA and 0, -0.047, and -0.1 for SV40<span class="hlt">ori</span>-λDNA, single bright spots at the single-stranded regions were frequently induced under higher negative supercoil densities of -0.095 for λDNA and -0.1 for SV40<span class="hlt">ori</span>-λDNA. However, single bright spots of the single-stranded regions were rarely observed below a negative supercoil density of -0.045 and -0.047 for λDNA and SV40<span class="hlt">ori</span>-λDNA, respectively. The probability of occurrence of the local denaturation increased with negative superhelicity for both λDNA and SV40<span class="hlt">ori</span>-λDNA. PMID:25697222</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015A%26A...582A.110B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015A%26A...582A.110B"><span id="translatedtitle">The magnetic field of ζ Orionis A</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Blazère, A.; Neiner, C.; Tkachenko, A.; Bouret, J.-C.; Rivinius, Th.</p> <p>2015-10-01</p> <p>Context. ζ <span class="hlt">Ori</span> A is a hot star claimed to host a weak magnetic field, but no clear magnetic detection was obtained so far. In addition, it was recently shown to be a binary system composed of a O9.5I supergiant and a B1IV star. Aims: We aim at verifying the presence of a magnetic field in ζ <span class="hlt">Ori</span> A, identifying to which of the two binary components it belongs (or whether both stars are magnetic), and characterizing the field. Methods: Very high signal-to-noise spectropolarimetric data were obtained with Narval at the Bernard Lyot Telescope (TBL) in France. Archival HEROS, FEROS and UVES spectroscopic data were also used. The data were first disentangled to separate the two components. We then analyzed them with the least-squares deconvolution technique to extract the magnetic information. Results: We confirm that ζ <span class="hlt">Ori</span> A is magnetic. We find that the supergiant component ζ <span class="hlt">Ori</span> Aa is the magnetic component: Zeeman signatures are observed and rotational modulation of the longitudinal magnetic field is clearly detected with a period of 6.829 d. This is the only magnetic O supergiant known as of today. With an oblique dipole field model of the Stokes V profiles, we show that the polar field strength is ~140 G. Because the magnetic field is weak and the stellar wind is strong, ζ <span class="hlt">Ori</span> Aa does not host a centrifugally supported magnetosphere. It may host a dynamical magnetosphere. Its companion ζ <span class="hlt">Ori</span> Ab does not show any magnetic signature, with an upper limit on the undetected field of ~300 G. Based on observations obtained at the Télescope Bernard Lyot (USR5026) operated by the Observatoire Midi-Pyrénées, Université de Toulouse (Paul Sabatier), Centre National de la Recherche Scientifique of France.Appendix A is available in electronic form at http://www.aanda.org</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/16201134','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/16201134"><span id="translatedtitle">Human evolution in Polynesia.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Whyte, Adele L H; Marshall, Stephen J; Chambers, Geoffrey K</p> <p>2005-04-01</p> <p>The number of eastern Polynesian females required to found the Maori population of Aotearoa (New Zealand) has been recalculated. Our estimates use computer simulations that incorporate realistic sigmoid population growth models and include previously published and new mitochondrial DNA (mtDNA) 3' hypervariable region 1 sequences from M?<span class="hlt">ori</span> (N = 109) and other eastern Polynesian (N = 125) volunteers. Approximately 190 (170-230) women are estimated to have been present in the founding waka (canoes). This new figure is more than double the previous estimate (Murray-McIntosh et al. 1998). Our claim for a large Maori founding population fits well with M?<span class="hlt">ori</span> oral history and has additional support from M?<span class="hlt">ori</span> paleodemography studies based on fertility estimates (Brewis et al. 1990; Pool 1991). An increasing body of data, including our own, supports the concept of planned multiple settlement voyages to Aotearoa by Polynesian navigators, leading us to suggest that theories for an "accidental discovery" of Aotearoa can now be completely disregarded. Four rare and novel M?<span class="hlt">ori</span> mtDNA haplotypes have been identified in the present study, but we are unable to assign the immediate origin of M?<span class="hlt">ori</span> to an exact Pacific island "homeland" because these haplotypes are not currently known elsewhere in Polynesia. We also discuss briefly the ultimate origin of all Polynesians (including M?<span class="hlt">ori</span>) in a wider context. In general, we support the emerging consensus for Pacific origins most closely encapsulated by the "slow boat" model (Oppenheimer and Richards 2001a). Previously "competing" models for the settlement of Oceania are seen as extremes in a continuum of possibilities with the slow boat representing an "intermediate" model. We suggest that a complete account is now close, incorporating data from all relevant interdisciplinary fields to provide a "synthetic total evidence theory." PMID:16201134</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_19 --> <div id="page_20" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="381"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2557697','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2557697"><span id="translatedtitle">Measles epidemiology and outbreak response immunization in a rural community in Peru.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Sniadack, D. H.; Moscoso, B.; Aguilar, R.; Heath, J.; Bellini, W.; Chiu, M. C.</p> <p>1999-01-01</p> <p>Only limited data are available on the impact of measles outbreak response immunization (<span class="hlt">ORI</span>) in developing countries. We conducted a community survey in Espindola, a rural border community in northern Peru, following a measles outbreak and subsequent <span class="hlt">ORI</span> to study the epidemiology and impact of the outbreak and to evaluate the costs and benefits of measles <span class="hlt">ORI</span>. During the outbreak, 150 of the 553 Espindola residents developed clinical cases of measles. Adults accounted for 44.0% of cases, and were frequently identified as primary cases. The attack rate among all susceptible people was 45.5% and was highest (61.2%) for the 16-20 year age group. Among adults, significant risk factors for developing measles included being aged 16-20 years (relative risk [RR] = 3.06, 95% CI = 2.08, 4.49) and being male (RR = 1.73, 95% CI = 1.11, 2.71). Among serologically confirmed cases, 60.7% developed diarrhoea and 32.1% pneumonia. The overall case-fatality rate was 3.3%, but reached 19.1% in the 0-23-month age group. Failure to reach children through either routine immunization or national campaigns made this community vulnerable to the severe and extensive impact of measles virus importation. The <span class="hlt">ORI</span> campaign targeted non-measles case children aged 6 months to 15 years, regardless of their previous immunization status, and was effective in terminating this measles outbreak and in preventing morbidity, loss of livelihood and death despite the involvement of large numbers of adults in measles transmission. The last measles case occurred within 3 weeks of completing <span class="hlt">ORI</span>. The <span class="hlt">ORI</span> campaign, which would have cost approximately US$ 3000 in 1998, saved as many as 1155 person-days of work among 77 adults, prevented an estimated 87 cases of diarrhoea and 46 cases of pneumonia, and averted 5 deaths. PMID:10444877</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4297629','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4297629"><span id="translatedtitle">Congenital Epidermoid Cyst Results in Muscle Fusion Defect in the Upper Lip</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Dogan, Fatih; Bucak, Ibrahim Hakan</p> <p>2014-01-01</p> <p>Epidermoid cysts are rarely detected malformations in the oral cavity. Their development sites are the sublingual, submaxillary, and submandibular spaces. In this paper, we report a three-month-old infant who was admitted to our hospital due upper lip swelling. Magnetic resonance imaging showed that she had a two-centimeter cystic lesion and fusion defects of orbicularis <span class="hlt">oris</span> muscle. The cyst was surgically removed and histopathological diagnosis was epidermoid cyst. In recent literature, we could not find reports related to orbicularis <span class="hlt">oris</span> muscle fusion defects because of epidermoid cyst. PMID:25628908</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=19720041301&hterms=goethe&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3Dgoethe','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=19720041301&hterms=goethe&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D50%26Ntt%3Dgoethe"><span id="translatedtitle">Scanner observations of cool stars from 3400 to 11,000 A.</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Fay, T.; Honeycutt, R. K.</p> <p>1972-01-01</p> <p>Evaluation of photoelectric scans of the M supergiant alpha <span class="hlt">Ori</span> and the carbon stars 19 Psc, W <span class="hlt">Ori</span>, and DS Peg made at 20-A resolution from 3400 to 6000 A and at 40-A resolution from 6000 to 11,000 A. The data are corrected for atmospheric extinction and for the instrumental response to obtain plots of log flux per unit frequency interval versus wavelength. The dominant spectral features are due to C2, CN, and TiO; the variation of these features with spectral class is pointed out.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=19770059489&hterms=gem+strengths&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dgem%2Bstrengths','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=19770059489&hterms=gem+strengths&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3Dgem%2Bstrengths"><span id="translatedtitle">Observed departures from LTE ionization equilibrium in late-type giants</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ramsey, L. W.</p> <p>1977-01-01</p> <p>Photoelectric scans of the Ca I line at 6572 A and the forbidden Ca II transition at 7323 A are studied in the K giant alpha Tau, the M supergiant alpha <span class="hlt">Ori</span>, and the M giants beta And, alpha Cet, mu Gem, and beta Peg. The relative strengths of these lines are shown to be indicative of the ratio of the relative number densities of the neutral and ionized species in the photosphere. The analysis indicates an overionization relative to LTE in qualitative agreement with the theoretical calculations of Auman and Woodrow for the K and M giants. The M supergiant alpha <span class="hlt">Ori</span> exhibits a large overionization relative to LTE.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6168891','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6168891"><span id="translatedtitle">Maleic anhydride-polyether-polyamine reaction product and motor fuel composition containing same</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Sung, R.L.</p> <p>1987-04-21</p> <p>A material is described having a use as a motor fuel additive for controlling engine octane requirement increase (<span class="hlt">ORI</span>), controlling and reducing hydrocarbon and carbon monoxide engine emissions, and having carburetor detergency properties. The material is the reaction product of maleic anhydride, a polyether polyamine, preferably a polyether diamine, and a hydrocarbyl polyamine, preferably an n-alkyl-alkylene diamine. A concentrate comprising the prescribed reaction product dissolved in a hydrocarbon solvent is also described. Motor fuels containing the reaction product additive of the instant invention show improved <span class="hlt">ORI</span> control and carburetor detergency in comparison with motor fuels without the reaction product additive.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19940029761','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19940029761"><span id="translatedtitle">IUE observations of new A star candidate proto-planetary systems</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Grady, Carol A.</p> <p>1994-01-01</p> <p>As a result of the detection of accreting gas in the A5e PMS Herbig Ae star, HR 5999, most of the observations for this IUE program were devoted to Herbig Ae stars rather than to main sequence A stars. Mid-UV emission at optical minimum light was detected for UX <span class="hlt">Ori</span> (A1e), BF <span class="hlt">Ori</span> (A5e), and CQ Tau (F2e). The presence of accreting gas in HD 45677 and HD 50138 prompted reclassification of these stars as Herbig Be stars rather than as protoplanetary nebulae. Detailed results are discussed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1990A%26A...232...70E','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1990A%26A...232...70E"><span id="translatedtitle">High resolution spectroscopy of the new FU Orionis object BBW 76</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Eisloeffel, J.; Hessman, F. V.; Mundt, R.</p> <p>1990-06-01</p> <p>High-resolution spectra of the new FU Orionis object BBW 76 are presented. Although the photometric outburst of this FU Orionis object could not be observed, its spectral characteristics clearly identify it as belonging to this class. BBW 76 shows Balmer line profiles typical for FU Orionis stars. Its absorption line spectrum and, in particular, the line widths are strikingly similar to that of FU <span class="hlt">Ori</span>. Other similarities to FU <span class="hlt">Ori</span> are the presence of an arclike nebula, and the FIR luminosities and color temperatures.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012JIPM...28..401O','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012JIPM...28..401O"><span id="translatedtitle">In-house Information Processing and Management System in Otsuka Chemical Ltd.</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Ogata, Masahiko; Uchida, Kiyoshi; Tanioka, Kyoko</p> <p></p> <p>This paper describes objectives and background of developing an in-house information processing and management system (<span class="hlt">ORIS</span>), the system outline, and future subjects to be solved. <span class="hlt">ORIS</span> aims to share in-house information resources and to provide prompt and versatile searching. It was started to be developed in Nov. 1984, and has been operated since Feb. 1985. Only three months passed since the system has been run so that it is hard to evaluate it at present. Consolidation of the database, PR of the system, control of primary materials and so on are regarded as subjects to be solved in near future.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/15338265','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/15338265"><span id="translatedtitle">Resolving within- and between-population variation in feeding ecology with a biomechanical model.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Osenberg, Craig W; Huckins, Casey J F; Kaltenberg, Anthony; Martinez, Ari</p> <p>2004-09-01</p> <p>Studies of phenotypic plasticity have emphasized the effect of the environment on the phenotype, but plasticity can also be used as a tool to study the functional significance of key traits. By inducing variation in phenotypes and testing quantitative models that predict performance based on biological mechanisms, we can develop functionally general models of performance. Pumpkinseed sunfish from lakes with high snail availability have large <span class="hlt">levator</span> posterior muscles (which are used to crush snail shells), whereas fish from lakes with few snails have relatively small muscles. Here we: (1) quantify differences in the feeding ability of an ontogenetic series of pumpkinseed from two populations; and (2) evaluate whether a biomechanical model can resolve the observed ontogenetic and between-population variation in feeding ecology. Mass, but not length, of the <span class="hlt">levator</span> posterior muscle in fish from Three Lakes (a lake rich in snails) was greater than for comparably sized fish from Wintergreen Lake (a lake with few snails). Handling times were shorter, crushing strengths were 71% greater, and foraging rate (snail tissue mass consumed per time) and the fraction of thick-shelled snails in the diet were approximately 100% greater for fish from Three Lakes compared to comparably sized fish from Wintergreen. These between-lake differences were not significant after adjusting for variation in pharyngeal morphology, suggesting that the biomechanical model of snail crushing resolved observed ontogenetic and population-level variation in the feeding ecology of pumpkinseed. PMID:15338265</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23136343','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23136343"><span id="translatedtitle">A neuromechanical model for the neuronal basis of curve walking in the stick insect.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Knops, S; Tth, T I; Guschlbauer, C; Gruhn, M; Daun-Gruhn, S</p> <p>2013-02-01</p> <p>The coordination of the movement of single and multiple limbs is essential for the generation of locomotion. Movement about single joints and the resulting stepping patterns are usually generated by the activity of antagonistic muscle pairs. In the stick insect, the three major muscle pairs of a leg are the protractor and retractor coxae, the <span class="hlt">levator</span> and depressor trochanteris, and the flexor and extensor tibiae. The protractor and retractor move the coxa, and thereby the leg, forward and backward. The <span class="hlt">levator</span> and depressor move the femur up and down. The flexor flexes, and the extensor extends the tibia about the femur-tibia joint. The underlying neuronal mechanisms for a forward stepping middle leg have been thoroughly investigated in experimental and theoretical studies. However, the details of the neuronal and mechanical mechanisms driving a stepping single leg in situations other than forward walking remain largely unknown. Here, we present a neuromechanical model of the coupled three joint control system of the stick insect's middle leg. The model can generate forward, backward, or sideward stepping. Switching between them is achieved by changing only a few central signals controlling the neuromechanical model. In kinematic simulations, we are able to generate curve walking with two different mechanisms. In the first, the inner middle leg is switched from forward to sideward and in the second to backward stepping. Both are observed in the behaving animal, and in the model and animal alike, backward stepping of the inner middle leg produces tighter turns than sideward stepping. PMID:23136343</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/22290138','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/22290138"><span id="translatedtitle">Dominance of local sensory signals over inter-segmental effects in a motor system: experiments.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Borgmann, Anke; Toth, Tibor I; Gruhn, Matthias; Daun-Gruhn, Silvia; Bschges, Ansgar</p> <p>2012-01-31</p> <p>Legged locomotion requires that information local to one leg, and inter-segmental signals coming from the other legs are processed appropriately to establish a coordinated walking pattern. However, very little is known about the relative importance of local and inter-segmental signals when they converge upon the central pattern generators (CPGs) of different leg joints. We investigated this question on the CPG of the middle leg coxa-trochanter (CTr)-joint of the stick insect which is responsible for lifting and lowering the leg. We used a semi-intact preparation with an intact front leg stepping on a treadmill, and simultaneously stimulated load sensors of the middle leg. We found that middle leg load signals induce bursts in the middle leg depressor motoneurons (MNs). The same local load signals could also elicit rhythmic activity in the CPG of the middle leg CTr-joint when the stimulation of middle leg load sensors coincided with front leg stepping. However, the influence of front leg stepping was generally weak such that front leg stepping alone was only rarely accompanied by switching between middle leg <span class="hlt">levator</span> and depressor MN activity. We therefore conclude that the impact of the local sensory signals on the <span class="hlt">levator</span>-depressor motor system is stronger than the inter-segmental influence through front leg stepping. PMID:22290138</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/20668273','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/20668273"><span id="translatedtitle">Activity patterns and timing of muscle activity in the forward walking and backward walking stick insect Carausius morosus.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rosenbaum, Philipp; Wosnitza, Anne; Bschges, Ansgar; Gruhn, Matthias</p> <p>2010-09-01</p> <p>Understanding how animals control locomotion in different behaviors requires understanding both the kinematics of leg movements and the neural activity underlying these movements. Stick insect leg kinematics differ in forward and backward walking. Describing leg muscle activity in these behaviors is a first step toward understanding the neuronal basis for these differences. We report here the phasing of EMG activities and latencies of first spikes relative to precise electrical measurements of middle leg tarsus touchdown and liftoff of three pairs (protractor/retractor coxae, <span class="hlt">levator</span>/depressor trochanteris, extensor/flexor tibiae) of stick insect middle leg antagonistic muscles that play central roles in generating leg movements during forward and backward straight walking. Forward walking stance phase muscle (depressor, flexor, and retractor) activities were tightly coupled to touchdown, beginning on average 93 ms prior to and 9 and 35 ms after touchdown, respectively. Forward walking swing phase muscle (<span class="hlt">levator</span>, extensor, and protractor) activities were less tightly coupled to liftoff, beginning on average 100, 67, and 37 ms before liftoff, respectively. In backward walking the protractor/retractor muscles reversed their phasing compared with forward walking, with the retractor being active during swing and the protractor during stance. Comparison of intact animal and reduced two- and one-middle-leg preparations during forward straight walking showed only small alterations in overall EMG activity but changes in first spike latencies in most muscles. Changing body height, most likely due to changes in leg joint loading, altered the intensity, but not the timing, of depressor muscle activity. PMID:20668273</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24705236','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24705236"><span id="translatedtitle">Transient and isolated neurogenic blepharoptosis after medial orbital wall reconstruction.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Song, Hyunsuk; Lim, Seong Yoon; Park, Myong Chul; Lee, Il Jae; Park, Dong Ha</p> <p>2014-05-01</p> <p>Neurogenic blepharoptosis related to orbital surgery is very rare and only 1 report was published in the literature. This report presents 1 case of transient and isolated neurogenic blepharoptosis after medial orbital wall reconstruction. A 12-year-old male patient who suffered from periorbital trauma visited our hospital with right periorbital pain. During the physical examination, mild ecchymosis and eyelid edema were reported; however, there were no signs of either limitation of ocular motion or anisocoria. On the orbital CT images, a 17 mm 20 mm-sized medial orbital bony defect was observed and the medial rectus muscle and orbital fat were herniated. The operation was performed 12 days after injury and the transcaruncular approach was used to reach the medial orbital wall. After the operation, he had right side blepharoptosis with mild eyelid edema and ecchymosis. However, ocular movement was normal and there were no signs of anisocoria. He did not receive any additional medication for blepharoptosis and was discharged 3 days postoperation. By the ninth day of postoperative recovery, the patient still suffered from right blepharoptosis with no <span class="hlt">levator</span> palpebrae superioris muscle function. We prescribed a low dose of oral corticosteroid and the patient was monitored on a weekly basis. Finally, he recovered completely with normal symmetric eyelid position and <span class="hlt">levator</span> function. PMID:24705236</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4319537','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4319537"><span id="translatedtitle">A Prototype External Magnetic Eyelid Device for Blepharoptosis</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Houston, Kevin E.; Tomasi, Matteo; Yoon, Michael; Paschalis, Eleftherios I.</p> <p>2014-01-01</p> <p>Purpose To test a prototype magnet system (magnetic <span class="hlt">levator</span> prosthesis) for the ability to comfortably and non-invasively provide eye opening with maintenance of the blink in people with paralytic ptosis and determine preliminary efficacy for short-term clinical application. Methods The prototype device consisted of a magnet on a spectacle frame and a micro-magnet array mounted externally on the eyelid. Participants with unilateral CN III palsy (n=3) trialed the predicate (ptosis crutch) and magnet device. Video analysis was used to quantify changes in eyelid opening and subjective responses were documented with a rating scale. A 20-minute and then a 1-week trial were offered. Results The magnetic <span class="hlt">levator</span> prosthesis device was effective to provide eye opening while allowing, at minimum, a volitional blink without ill effects on the eyelid skin or ocular surface. Comfort scores ranged from 6 to 9 out of 10 over 3 evaluations. All patients chose an extended trial of the magnet device and reported continued 8-9/10 comfort and efficacy after the extended 1-week trial. Conclusions Comfortable and effective restoration of eye opening with maintenance of the blink is feasible using external static magnets and warrants further study. Translational Relevance This is the first careful documentation of the successful use of an externally mounted static magnet system to treat paralytic ptosis. PMID:25674358</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2596957','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2596957"><span id="translatedtitle">Subject Specific Finite Elasticity Simulations of the Pelvic Floor</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Noakes, Kimberley F.; Pullan, Andrew J.; Bissett, Ian P.; Cheng, Leo K.</p> <p>2008-01-01</p> <p>An anatomically realistic computational model of the pelvic floor and anal canal regions was used in this study to examine the mechanics of normal defecatory function within the female pelvic floor. This subject-specific, MRI-based model enabled mechanical simulations to be performed and quantitatively assessed against experimental data retrieved from the same volunteer. The <span class="hlt">levator</span> ani muscle group mesh was used as the domain over which the governing equations of finite elasticity were solved using the finite element method with a Mooney-Rivlin material law. Deformation of the <span class="hlt">levator</span> ani was simulated during a ‘bear down’ maneuver in order to visualize the way this muscle group functions in an asymptomatic subject. A pressure of 4 kPa was imposed on the mesh and the computed mesh displacements were compared to those obtained from dynamic MR images with an average, experimentally consistent, downwards displacement of 27.2 mm being achieved. The RMS error for this movement was 0.7 mm equating to a percentage error of 2.6% in the supero-inferior direction and 13.7 mm or 74.5% in the antero-posterior direction. PMID:18757058</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171818','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171818"><span id="translatedtitle">Localisation of motoneurons supplying the extra-ocular muscles of the rat using horseradish peroxidase and fluorescent double labelling.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Labandeira Garcia, J L; Gomez Segade, L A; Suarez Nuez, J M</p> <p>1983-01-01</p> <p>This paper describes a qualitative and quantitative investigation into the location of the motoneurons innervating the extra-ocular muscles of the rat. Injections of horseradish peroxidase, bisbenzimide, propidium iodide and DAPI-primuline were made either in one or simultaneously in two muscles. Unlike those of the cat, rabbit and monkey, the motoneurons which make up the oculomotor nucleus of the rat are not arranged in spatially separate subgroups belonging each to its corresponding extra-ocular muscle, but instead allow a high degree of superposition among the motor pools which they compose. The motoneurons innervating the lateral rectus and inferior oblique muscles are all homolateral; those of the medial and inferior rectus muscles are mainly homolateral with a few contralateral exceptions; and those of the superior rectus, <span class="hlt">levator</span> palpebrae and superior oblique muscles are mainly contralateral with a small minority of homolateral exceptions. As well as from the main motor pools with which they are associated, the medial rectus, inferior rectus, superior rectus, <span class="hlt">levator</span> palpebrae, superior oblique and lateral rectus muscles all receive innervation from motoneurons lying among the fibres of the fasciculus longitudinalis medialis. All these observations are supported by quantitative data. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 PMID:6195140</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/11103518','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/11103518"><span id="translatedtitle">Arterial vascularization of the uropygial glands (Gl. uropygialis) in geese (Anser anser) and ducks (Anas platyrhynches).</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Aslan, K; Ozcan, S; Kurtul, I</p> <p>2000-10-01</p> <p>In the present study, arterial vascularization of the uropygial glands (Gl. uropygialis) of 10 adult geese (Anser anser) and 10 adult ducks (Anas platyrhynches) were studied. Takilon was injected into the median coccygeal arteries of six specimens from each species, and Latex (a natural rubber with ammonia) into those of four specimens. Takilon-injected specimens were corrosion casted, and arteries nourishing the gland were revealed via dissection. Vascularization of the uropygial glands of both the goose and the duck was observed to be the right (a. gl. uropygii dextra), left (a. gl. uropygi sinistra) and ventral (a. gl. uropygi ventralis) glandular uropygial arteries, arising from the median coccygeal (a. coccygea media) artery. Both the right and left glandular uropygial arteries were observed, divided into four branches as follows; muscular ramus (ramus muscularis), medial ramus (ramus medialis), ventral ramus (ramus ventralis) and lateral ramus (ramus lateralis). Of these, as the lateral, medial and ventral branches feed the gland, the muscular branch provides blood for the lateral coccygeal (m. coccygealis lateralis) and <span class="hlt">levator</span> coccygeal (m. <span class="hlt">levator</span> coccygealis) muscles, and the skin. Among the arteries mentioned above, anastomosis between the first and the second branches of the right ventral uropygial arteries in the five geese and five ducks was found. PMID:11103518</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26489576','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26489576"><span id="translatedtitle">[A Case of Locally Advanced Rectal Cancer Successfully Treated by Conversion Surgery after Multidisciplinary Treatment].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Shimizu, Yosuke; Yamashita, Shinya; Tominaga, Harumi; Kimura, Yuri; Odagiri, Kazuki; Kurokawa, Tomoaki; Yamaguchi, Megumi; Takahashi, Gen; Sawada, Genta; Jeongho, Moon; Inoue, Masasi; Irei, Toshimitsu; Nakahira, Sin; Hatanaka, Nobutaka</p> <p>2015-10-01</p> <p>A 70-year-old woman who complained of abdominal pain and a prolapsed tumor from the anus was diagnosed with an intestinal obstruction resulting from anal canal cancer. Computed tomography (CT) and magnetic resonance imaging revealed a huge tumor (11512 cm) invading the vagina and <span class="hlt">levator</span> ani muscle. Enlarged inguinal lymph nodes on both sides indicated metastasis. The clinical stage was T4b (vagina, <span class="hlt">levator</span> ani muscle, and pudenda) N0H0M1a (LYM), stage IV (Japanese Classification of Colorectal Carcinoma: 8th edition). As curative resection was not possible, a transvers colostomy was performed to relieve the intestinal obstruction. This was followed by chemoradiotherapy (45 Gy/1.8 Gy25; TS-1, 80 mg/body for 2 weeks and a 1-week interval, for 2 courses) and up to 10 courses of Bev+mFOLFOX6 continuously. After this regimen, there was a remarkable reduction in tumor size. Positron emission tomography-CT revealed no FDG uptake in the primary rectal site or inguinal lymph nodes, but a maximum standardized uptake value (SUVmax) of 6.3 was detected in the vagina. Six weeks after chemotherapy, the patient underwent a pelvic exenteration including resection of the vagina, bladder, and pudenda. The pathological stage was yp T4b (vagina) N0H0M0, stage?. Curative resection was performed, and the patient had a Grade 2 pathological response after chemoradiotherapy. PMID:26489576</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/16298856','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/16298856"><span id="translatedtitle">A shell finite element model of the pelvic floor muscles.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>d'Aulignac, D; Martins, J A C; Pires, E B; Mascarenhas, T; Jorge, R M Natal</p> <p>2005-10-01</p> <p>The pelvic floor gives support to the organs in the abdominal cavity. Using the dataset made public in (Janda et al. J. Biomech. (2003) 36(6), pp. 749-757), we have reconstructed the geometry of one of the most important parts of the pelvic floor, the <span class="hlt">levator</span> ani, using NURB surfaces. Once the surface is triangulated, the corresponding mesh is used in a finite element analysis with shell elements. Based on the 3D behavior of the muscle we have constructed a shell that takes into account the direction of the muscle fibers and the incompressibility of the tissue. The constitutive model for the isotropic strain energy and the passive strain energy stored in the fibers is adapted from Humphrey's model for cardiac muscles. To this the active behavior of the skeletal muscle is added. We present preliminary results of a simulation of the <span class="hlt">levator</span> ani muscle under pressure and with active contraction. This research aims at helping simulate the damages to the pelvic floor that can occur after childbirth. PMID:16298856</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3934473','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3934473"><span id="translatedtitle">Magnetic resonance imaging in rectal cancer: A surgeon’s perspective</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Saklani, Avanish P; Bae, Sung Uk; Clayton, Amy; Kim, Nam Kyu</p> <p>2014-01-01</p> <p>Magnetic resonance imaging (MRI) in rectal cancer was first investigated in 1999 and has become almost mandatory in planning rectal cancer treatment. MRI has a high accuracy in predicting circumferential resection margin involvement and is used to plan neoadjuvant therapy. The accuracy of MRI in assessing mesorectal lymph nodes remains moderate, as there are no reliable criteria to assess nodal involvement. MRI seems to be good in assessing peritoneal involvement in upper rectal cancer; this however has been assessed in only a few studies and needs further research. For low rectal cancers, mesorectum is thin at the level of <span class="hlt">levator</span> ani especially in relation to prostate; so predicting circumferential resection margin involvement is not easy. However high spatial resolution coronal imaging shows <span class="hlt">levator</span> muscles, sphincter complex and intersphincteric plane accurately. This is used to stage low rectal tumors and plan plane of surgery (standard surgery, intersphincteric resection, Extralevator abdominoperineal resection). While most centres perform MRI post chemoradiotherapy, its role in accurate staging post neoadjuvant therapy remains debatable. THe role of Diffusion weighted MRI post neoadjuvant therapy is being evaluated in research settings. PMID:24616572</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_20 --> <div id="page_21" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="401"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3968266','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3968266"><span id="translatedtitle">Nerves and fasciae in and around the paracolpium or paravaginal tissue: an immunohistochemical study using elderly donated cadavers</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hieda, Keisuke; Sasaki, Hiromasa; Kurokawa, Tetsuji; Miyake, Hideaki; Fujisawa, Masato; Murakami, Gen; Fujimiya, Mineko</p> <p>2014-01-01</p> <p>The paracolpium or paravaginal tissue is surrounded by the vaginal wall, the pubocervical fascia and the rectovaginal septum (Denonvilliers' fascia). To clarify the configuration of nerves and fasciae in and around the paracolpium, we examined histological sections of 10 elderly cadavers. The paracolpium contained the distal part of the pelvic autonomic nerve plexus and its branches: the cavernous nerve, the nerves to the urethra and the nerves to the internal anal sphincter (NIAS). The NIAS ran postero-inferiorly along the superior fascia of the <span class="hlt">levator</span> ani muscle to reach the longitudinal muscle layer of the rectum. In two nulliparous and one multiparous women, the pubocervical fascia and the rectovaginal septum were distinct and connected with the superior fascia of the <span class="hlt">levator</span> at the tendinous arch of the pelvic fasciae. In these three cadavers, the pelvic plexus and its distal branches were distributed almost evenly in the paracolpium and sandwiched by the pubocervical and Denonvilliers' fasciae. By contrast, in five multiparous women, these nerves were divided into the anterosuperior group (bladder detrusor nerves) and the postero-inferior group (NIAS, cavernous and urethral nerves) by the well-developed venous plexus in combination with the fragmented or unclear fasciae. Although the small number of specimens was a major limitation of this study, we hypothesized that, in combination with destruction of the basic fascial architecture due to vaginal delivery and aging, the pelvic plexus is likely to change from a sheet-like configuration to several bundles. PMID:24693482</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/17154285','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/17154285"><span id="translatedtitle">Cranial musculature in the larva of the caecilian, Ichthyophis kohtaoensis (Lissamphibia: Gymnophiona).</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kleinteich, Thomas; Haas, Alexander</p> <p>2007-01-01</p> <p>Within the Gymnophiona (caecilians) oviparous species with biphasic life-cycles possess a free living semi-aquatic larval stage that feeds in aquatic habitats. The larvae pass through a metamorphosis to a purely terrestrial adult stage. It is likely that the cranial morphology of caecilian larvae has specializations for aquatic feeding. However, little is known about the cranial morphology, and the cranial musculature is especially neglected in the literature. This study provides a detailed description of the jaw and hyobranchial musculature in larval stages of a caecilian. We studied late embryonic and early larval specimens of Ichthyophis kohtaoensis. Furthermore, we compared and homologized the cranial muscles found in larval I. kohtaoensis with the muscles described for adult caecilians. Most cranial muscles of larval I. kohtaoensis are also present in the adult, except for the m. <span class="hlt">levator</span> mandibulae externus and the m. subarcualis obliquus II. Our results were compared with the data available for larval frogs and salamanders in order to hypothesize the cranial musculature in the larva of the most recent common ancestor of the Lissamphibia. Larval caecilians, frog tadpoles, and salamander larvae share many characters in their cranial musculature, which, consequently, can be assigned to the lissamphibian ground pattern. However, the m. pterygoideus and the m. <span class="hlt">levator</span> quadrati are unique to the Gymnophiona. PMID:17154285</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=297573','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=297573"><span id="translatedtitle">Measuring the effect of spray plume angle on the accuracy of droplet size data</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>Analysis of droplet size data using laser diffraction allows for quick and easy assessment of droplet size for agricultural spray nozzles and pesticides; however, operation and setup of the instrument and test system can potentially influence the accuracy of the data. One of the factors is the <span class="hlt">orie</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=20060030581&hterms=vr&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dvr','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=20060030581&hterms=vr&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dvr"><span id="translatedtitle">CNO abundances in the quintuplet cluster M supergiant 5-7</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Ramirez, S. V.; Sellgren, K.; Blum, R.; Terndrup, D. M.</p> <p>2002-01-01</p> <p>We present and analyze infrared spectra of the supergiant VR 5-7, in the Quintuplet cluster 30 pc from the Galactic center. Within the uncertainties, the [C/H],[N/H], and [O/H] abundances in this star are equal of <span class="hlt">Ori</span>, a star which exhibits mixing of CNO processed elements, but distinct from the abundance patterns in IRS 7.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2000AAS...197.1006B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2000AAS...197.1006B"><span id="translatedtitle">Large Scale Variability Survey of Orion II: mapping the young, low-mass stellar populations</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Briceo, C.; Calvet, N.; Hartmann, L. W.; Vivas, A. K.</p> <p>2000-12-01</p> <p>We present further results of our ongoing large scale variability survey of the Orion OB1 Association, carried out with the 8k x 8k CCD Mosaic Camera on the 1m Schmidt telescope at the Venezuela National Observatory. In an area of over 60 square degrees we have unveiled new populations of low-mass young stars over a range of environments, from the dense molecular clouds of the Orion belt region, <span class="hlt">Ori</span> OB 1b, to areas devoid of gas in Orion OB 1a. These new young stars span ages from 1-2 Myr in <span class="hlt">Ori</span> OB 1b to roughly 10 Myr in <span class="hlt">Ori</span> OB 1a, a likely scenario of sequential star formation triggered by the first generation of massive stars. Proxy indicators like H? emission and near-IR excesses show that accretion from circumstellar disks in the 10 Myr stars of <span class="hlt">Ori</span> OB 1a has mostly stopped. This population is a numerous analog of groups like TW Hya, making it an excellent laboratory to look for debris disks and study the epoch of planet formation in sparse, non-clustered environments. Research reported herein funded by NSF grant No. 9987367, and by CONICIT and Ministerio de Ciencia y Tecnologa, Venezuela.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-302.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-302.pdf"><span id="translatedtitle">42 CFR 93.302 - Institutional compliance with assurances.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... 42 Public Health 1 2011-10-01 2011-10-01 false Institutional compliance with assurances. 93.302 Section 93.302 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH... Institutional compliance with assurances. (a) Compliance with assurance. <span class="hlt">ORI</span> considers an institution...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-302.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-302.pdf"><span id="translatedtitle">42 CFR 93.302 - Institutional compliance with assurances.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 42 Public Health 1 2010-10-01 2010-10-01 false Institutional compliance with assurances. 93.302 Section 93.302 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH... Institutional compliance with assurances. (a) Compliance with assurance. <span class="hlt">ORI</span> considers an institution...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.youtube.com/watch?v=WFsByt7pul0','SCIGOVIMAGE-NASA'); return false;" href="http://www.youtube.com/watch?v=WFsByt7pul0"><span id="translatedtitle">Orion Parachute Drop Test, July 18 - Duration: 10 minutes.</span></a></p> <p><a target="_blank" href="http://www.nasa.gov/multimedia/videogallery/index.html">NASA Video Gallery</a></p> <p></p> <p></p> <p>A C-17 plane dropped a test version of Orion from an altitude of 25,000 feet above the U.S. Army Yuma Proving Ground in southwestern Arizona on July 18, 2012. This test was the second to use an <span class="hlt">Ori</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/17140410','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/17140410"><span id="translatedtitle">Changes of initiation mass and cell dimensions by the 'eclipse'.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Zaritsky, Arieh; Vischer, Norbert; Rabinovitch, Avinoam</p> <p>2007-01-01</p> <p>The minimum time (E) required for a new pair of replication origins (<span class="hlt">ori</span>Cs) produced upon initiating a round of replication to be ready to initiate the next round after one cell mass doubling, the 'eclipse', is explained in terms of a minimal distance (l(min)) that the replication forks must move away from <span class="hlt">ori</span>C before <span class="hlt">ori</span>Cs can 'fire' again. In conditions demanding a scheduled initiation event before the relative distance l(min)/L(0.5) (L being the total chromosome length) is reached, initiation is presumably delayed. Under such circumstances, cell mass at the next initiation would be greater than the usual, constant Mi (cell mass per copy number of <span class="hlt">ori</span>C) prevailing in steady state of exponential growth. This model can be tested experimentally by extending the replication time C using thymine limitation at short doubling times tau in rich media to reach a relative eclipse E/C < l(min)/L(0.5). It is consistent with results obtained in experiments in which the number of replication 'positions'n (= C/tau) is increased beyond the natural maximum, causing the mean cell size to rise continuously, first by widening, then by lengthening, and finally by splitting its poles. The consequent branching is associated with casting off a small proportion of normal-sized cells and lysing DNA-less cells. Whether or how these phenomena are related to peptidoglycan composition and synthesis are moot questions. PMID:17140410</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-316.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-316.pdf"><span id="translatedtitle">42 CFR 93.316 - Completing the research misconduct process.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 42 Public Health 1 2010-10-01 2010-10-01 false Completing the research misconduct process. 93.316... POLICIES ON RESEARCH MISCONDUCT Responsibilities of Institutions The Institutional Investigation § 93.316 Completing the research misconduct process. (a) <span class="hlt">ORI</span> expects institutions to carry inquiries...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-316.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-316.pdf"><span id="translatedtitle">42 CFR 93.316 - Completing the research misconduct process.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... 42 Public Health 1 2011-10-01 2011-10-01 false Completing the research misconduct process. 93.316... POLICIES ON RESEARCH MISCONDUCT Responsibilities of Institutions The Institutional Investigation § 93.316 Completing the research misconduct process. (a) <span class="hlt">ORI</span> expects institutions to carry inquiries...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-501.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-501.pdf"><span id="translatedtitle">42 CFR 93.501 - Opportunity to contest findings of research misconduct and administrative actions.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... 42 Public Health 1 2011-10-01 2011-10-01 false Opportunity to contest findings of research... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative Actions General Information § 93.501 Opportunity...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-501.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-501.pdf"><span id="translatedtitle">42 CFR 93.501 - Opportunity to contest findings of research misconduct and administrative actions.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 42 Public Health 1 2010-10-01 2010-10-01 false Opportunity to contest findings of research... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative Actions General Information § 93.501 Opportunity...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-02-02/pdf/2012-2276.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-02-02/pdf/2012-2276.pdf"><span id="translatedtitle">77 FR 5254 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-02-02</p> <p>... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (<span class="hlt">ORI</span>) has... obtained from Creighton University (CU) and additional evidence gathered by the Office of...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title48-vol1/pdf/CFR-2013-title48-vol1-sec27-304-1.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title48-vol1/pdf/CFR-2013-title48-vol1-sec27-304-1.pdf"><span id="translatedtitle">48 CFR 27.304-1 - General.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>... contractor, the agency shall follow the applicable procedures at 37 CFR 401. (2) A small business concern <span class="hlt">or...)(i</span>) through (e)(1)(iv) in accordance with agency procedures and 37 CFR part 401. (c) Greater rights... least the following objectives (see 37 CFR 401.3(b) and 401.15): (1) Promoting the utilization...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title48-vol1/pdf/CFR-2010-title48-vol1-sec27-304-1.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title48-vol1/pdf/CFR-2010-title48-vol1-sec27-304-1.pdf"><span id="translatedtitle">48 CFR 27.304-1 - General.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... contractor, the agency shall follow the applicable procedures at 37 CFR 401. (2) A small business concern <span class="hlt">or...)(i</span>) through (e)(1)(iv) in accordance with agency procedures and 37 CFR part 401. (c) Greater rights... least the following objectives (see 37 CFR 401.3(b) and 401.15): (1) Promoting the utilization...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title48-vol1/pdf/CFR-2014-title48-vol1-sec27-304-1.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title48-vol1/pdf/CFR-2014-title48-vol1-sec27-304-1.pdf"><span id="translatedtitle">48 CFR 27.304-1 - General.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... contractor, the agency shall follow the applicable procedures at 37 CFR 401. (2) A small business concern <span class="hlt">or...)(i</span>) through (e)(1)(iv) in accordance with agency procedures and 37 CFR part 401. (c) Greater rights... least the following objectives (see 37 CFR 401.3(b) and 401.15): (1) Promoting the utilization...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title48-vol1/pdf/CFR-2011-title48-vol1-sec27-304-1.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title48-vol1/pdf/CFR-2011-title48-vol1-sec27-304-1.pdf"><span id="translatedtitle">48 CFR 27.304-1 - General.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... contractor, the agency shall follow the applicable procedures at 37 CFR 401. (2) A small business concern <span class="hlt">or...)(i</span>) through (e)(1)(iv) in accordance with agency procedures and 37 CFR part 401. (c) Greater rights... least the following objectives (see 37 CFR 401.3(b) and 401.15): (1) Promoting the utilization...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title48-vol1/pdf/CFR-2012-title48-vol1-sec27-304-1.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title48-vol1/pdf/CFR-2012-title48-vol1-sec27-304-1.pdf"><span id="translatedtitle">48 CFR 27.304-1 - General.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... contractor, the agency shall follow the applicable procedures at 37 CFR 401. (2) A small business concern <span class="hlt">or...)(i</span>) through (e)(1)(iv) in accordance with agency procedures and 37 CFR part 401. (c) Greater rights... least the following objectives (see 37 CFR 401.3(b) and 401.15): (1) Promoting the utilization...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=92951','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=92951"><span id="translatedtitle">Exploitation of Plasmid pMRC01 To Direct Transfer of Mobilizable Plasmids into Commercial Lactococcal Starter Strains</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hickey, Rita M.; Twomey, Denis P.; Ross, R. Paul; Hill, Colin</p> <p>2001-01-01</p> <p>Genetic analysis of the 60.2-kb lactococcal plasmid pMRC01 revealed a 19.6-kb region which includes putative genes for conjugal transfer of the plasmid and a sequence resembling an origin of transfer (<span class="hlt">ori</span>T). This <span class="hlt">ori</span>T-like sequence was amplified and cloned on a 312-bp segment into pCI372, allowing the resultant plasmid, pRH001, to be mobilized at a frequency of 3.4 10?4 transconjugants/donor cell from an MG1363 (recA mutant) host containing pMRC01. All of the resultant chloramphenicol-resistant transconjugants contained both pRH001 and genetic determinants responsible for bacteriocin production and immunity of pMRC01. This result is expected, given that transconjugants lacking the lacticin 3147 immunity determinants (on pMRC01) would be killed by bacteriocin produced by the donor cells. Indeed, incorporation of proteinase K in the mating mixture resulted in the isolation of transformants, of which 47% were bacteriocin deficient. Using such an approach, the <span class="hlt">ori</span>T-containing fragment was exploited to mobilize pRH001 alone to a number of lactococcal hosts. These results demonstrate that <span class="hlt">ori</span>T of pMRC01 has the potential to be used in the development of mobilizable food-grade vectors for the genetic enhancement of lactococcal starter strains, some of which may be difficult to transform. PMID:11375207</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_21 --> <div id="page_22" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="421"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=211517','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=211517"><span id="translatedtitle">Comparison of Three Near Infrared Spectrophotometers for Infestation Detection in Wild Blueberries Using Multivariate Calibration Models</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>A near-infrared spectroscopy (NIRS) method for automated non-destructive detection of insect infestation internal to small fruit is desirable because of the zero-to-zero tolerance of the fresh and processed fruit markets. Three NIRS instruments: the Ocean Optics SD2000, the Perten DA7000 and the <span class="hlt">Ori</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title7-vol1/pdf/CFR-2010-title7-vol1-sec15b-3.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title7-vol1/pdf/CFR-2010-title7-vol1-sec15b-3.pdf"><span id="translatedtitle">7 CFR 15b.3 - Definitions.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-01-01</p> <p>...; reproductive; digestive; genitourinary; hemic and lymphatic; skin; and endocrine; or (2) any mental <span class="hlt">or...)(i</span>) A college, university, or other postsecondary institution, or a public system of higher education; or (ii) A local educational agency (as defined in 20 U.S.C. 7801), system of vocational education,...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6138560','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6138560"><span id="translatedtitle">Radio continuum from FU Orionis stars</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Rodriguez, L.F.; Hartmann, L.W.; Chavira, E. Harvard-Smithsonian Center for Astrophysics, Cambridge, MA Instituto Nacional de Astrofisica, Optica y Electronica, Puebla )</p> <p>1990-12-01</p> <p>Using the very large array a sensitive search is conducted for 3.6-cm continuum emission toward four FU Orionis objects: FU <span class="hlt">Ori</span>, V1515 Cyg, V1057 Cyg, and Elias 1-12. V1057 Cyg and Elias 1-12 at the level of about 0.1 mJy is detected. The association of radio continuum emission with these FU <span class="hlt">Ori</span> objects strengthens a possible relation between FU <span class="hlt">Ori</span> stars and objects like L 1551 IRS 5 and Z CMa that are also sources of radio continuum emission and have been proposed as post-FU <span class="hlt">Ori</span> objects. Whether the radio continuum emission is caused by free-free emission from ionized ejecta or if it is optically thin emission from a dusty disk is discussed. It was determined that, in the archives of the Tonantzintla Observatory, a plate taken in 1957 does not show Elias 1-12. This result significantly narrows the time range for the epoch of the outburst of this source to between 1957 and 1965. 38 refs.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2009PMB....54.6837S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2009PMB....54.6837S"><span id="translatedtitle">Quantification of the optical surface reflection and surface roughness of articular cartilage using optical coherence tomography</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Saarakkala, Simo; Wang, Shu-Zhe; Huang, Yan-Ping; Zheng, Yong-Ping</p> <p>2009-11-01</p> <p>Optical coherence tomography (OCT) is a promising new technique for characterizing the structural changes of articular cartilage in osteoarthritis (OA). The calculation of quantitative parameters from the OCT signal is an important step to develop OCT as an effective diagnostic technique. In this study, two novel parameters for the quantification of optical surface reflection and surface roughness from OCT measurements are introduced: optical surface reflection coefficient (ORC), describing the amount of a ratio of the optical reflection from cartilage surface with respect to that from a reference material, and OCT roughness index (<span class="hlt">ORI</span>) indicating the smoothness of the cartilage surface. The sensitivity of ORC and <span class="hlt">ORI</span> to detect changes in bovine articular cartilage samples after enzymatic degradations of collagen and proteoglycans using collagenase and trypsin enzymes, respectively, was tested in vitro. A significant decrease (p < 0.001) in ORC as well as a significant increase (p < 0.001) in <span class="hlt">ORI</span> was observed after collagenase digestion. After trypsin digestion, no significant changes in ORC or <span class="hlt">ORI</span> were observed. To conclude, the new parameters introduced were demonstrated to be feasible and sensitive to detect typical OA-like degenerative changes in the collagen network. From the clinical point of view, the quantification of OCT measurements is of great interest since OCT probes have been already miniaturized and applied in patient studies during arthroscopy or open knee surgery in vivo. Further studies are still necessary to demonstrate the clinical capability of the introduced parameters for naturally occurring early OA changes in the cartilage.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/22078327','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/22078327"><span id="translatedtitle">HIGH-RESOLUTION INFRARED IMAGING AND SPECTROSCOPY OF THE Z CANIS MAJORIS SYSTEM DURING QUIESCENCE AND OUTBURST</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Hinkley, Sasha; Hillenbrand, Lynne; Crepp, Justin R.; Oppenheimer, Ben R.; Zimmerman, Neil; Brenner, Douglas; Rice, Emily L.; Pueyo, Laurent; Vasisht, Gautam; Roberts, Jennifer E.; Roberts, Lewis C. Jr.; Burruss, Rick; Wallace, J. Kent; Cady, Eric; Zhai, Chengxing; Kraus, Adam L.; Ireland, Michael J.; Beichman, Charles; Dekany, Richard; Parry, Ian R.; and others</p> <p>2013-01-20</p> <p>We present adaptive optics photometry and spectra in the JHKL bands along with high spectral resolution K-band spectroscopy for each component of the Z Canis Majoris system. Our high angular resolution photometry of this very young ({approx}<1 Myr) binary, comprised of an FU <span class="hlt">Ori</span> object and a Herbig Ae/Be star, was gathered shortly after the 2008 outburst while our high-resolution spectroscopy was gathered during a quiescent phase. Our photometry conclusively determines that the outburst was due solely to the embedded Herbig Ae/Be member, supporting results from earlier works, and that the optically visible FU <span class="hlt">Ori</span> component decreased slightly ({approx}30%) in luminosity during the same period, consistent with previous works on the variability of FU <span class="hlt">Ori</span> type systems. Further, our high-resolution K-band spectra definitively demonstrate that the 2.294 {mu}m CO absorption feature seen in composite spectra of the system is due solely to the FU <span class="hlt">Ori</span> component, while a prominent CO emission feature at the same wavelength, long suspected to be associated with the innermost regions of a circumstellar accretion disk, can be assigned to the Herbig Ae/Be member. These findings clarify previous analyses of the origin of the CO emission in this complex system.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2011-08-05/pdf/2011-19930.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2011-08-05/pdf/2011-19930.pdf"><span id="translatedtitle">76 FR 47589 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2011-08-05</p> <p>... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary... agrees not to appeal the jurisdiction of <span class="hlt">ORI</span> or request a U.S. Department of Health and Human...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-516.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-516.pdf"><span id="translatedtitle">42 CFR 93.516 - Standard and burden of proof.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... 42 Public Health 1 2011-10-01 2011-10-01 false Standard and burden of proof. 93.516 Section 93.516... Actions Hearing Process § 93.516 Standard and burden of proof. (a) Standard of proof. The standard of proof is the preponderance of the evidence. (b) Burden of proof. (1) <span class="hlt">ORI</span> bears the burden of proving...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-516.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-516.pdf"><span id="translatedtitle">42 CFR 93.516 - Standard and burden of proof.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 42 Public Health 1 2010-10-01 2010-10-01 false Standard and burden of proof. 93.516 Section 93.516... Actions Hearing Process § 93.516 Standard and burden of proof. (a) Standard of proof. The standard of proof is the preponderance of the evidence. (b) Burden of proof. (1) <span class="hlt">ORI</span> bears the burden of proving...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=19474&keyword=Recombinant+AND+DNA&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=49649782&CFTOKEN=65693920','EPA-EIMS'); return false;" href="http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=19474&keyword=Recombinant+AND+DNA&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=49649782&CFTOKEN=65693920"><span id="translatedtitle">MARKERS OF THE LOW-DOSE RADIATION RESPONSE</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>Ionizing radiation has a unique ability to induce damage simultaneously at multiple sites within a spatially restricted region of DNA. The resulting double-strand DNA breaks (DSBs) present a major threat to the integrity and stability of the genome. Our understanding of the <span class="hlt">ori</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2013-03-07/pdf/2013-05301.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2013-03-07/pdf/2013-05301.pdf"><span id="translatedtitle">78 FR 14797 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2013-03-07</p> <p>... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (<span class="hlt">ORI</span>) ] has... Mr. Adam C. Savine, former doctoral student, Department of Psychology, WUSTL, engaged in...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-11-20/pdf/2012-28209.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-11-20/pdf/2012-28209.pdf"><span id="translatedtitle">77 FR 69627 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-11-20</p> <p>... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (<span class="hlt">ORI</span>) has... Physiology, Department of Pediatrics and Physiology, UK, engaged in research misconduct in research...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-06-28/pdf/2012-15887.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-06-28/pdf/2012-15887.pdf"><span id="translatedtitle">77 FR 38632 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-06-28</p> <p>... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (<span class="hlt">ORI</span>) has... Health Science Institute (EOHSI), UMDNJ, engaged in research misconduct in research supported by...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-08-03/pdf/2012-18990.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-08-03/pdf/2012-18990.pdf"><span id="translatedtitle">77 FR 46438 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-08-03</p> <p>... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (<span class="hlt">ORI</span>) has..., former Director of the Laboratory of Glycoimmunotheraphy, JWCI, engaged in research misconduct...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-01-03/pdf/2011-33650.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-01-03/pdf/2011-33650.pdf"><span id="translatedtitle">77 FR 124 - Findings of Research Misconduct</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-01-03</p> <p>... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (<span class="hlt">ORI</span>) has..., SUNY US, engaged in research misconduct in research supported by National Institute of General...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/8380658','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/8380658"><span id="translatedtitle">Unusual properties of a replication-defective mutant SV40 large T antigen.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lorimer, H E; Reynisdttir, I; Ness, S; Prives, C</p> <p>1993-02-01</p> <p>The C11A mutant of SV40 large T antigen is unable to support the replication of viral origin containing DNA (<span class="hlt">ori</span>-DNA) in vivo or in vitro. The mutation within C11A at residue 522 (pro-->ser) is located within the presumptive ATPase region of T antigen. While C11A T antigen was previously reported to be defective in ATPase and DNA helicase activities, it was shown to be capable of binding specifically to DNA containing the viral replication origin. As the positions of many conditional mutations of SV40 T antigen are located within the ATPase domain we asked whether C11A might also exhibit temperature-sensitive defects. We found that several activities of C11A T antigen are conditionally defective. C11A T antigen was able to hydrolyze ATP, assemble into hexamers, and display ATP-dependent alterations in DNA binding and <span class="hlt">ori</span>-DNA structure at 33 degrees but not 41 degrees. Wild-type T antigen did not exhibit temperature-sensitive defects in these activities. C11A T antigen was completely unable to unwind <span class="hlt">ori</span>-DNA at either temperature. This defect in unwinding was trans-dominant; C11A T antigen inhibited <span class="hlt">ori</span>-DNA unwinding by wild-type T antigen. These data show that a mutant displaying a nonconditional defective phenotype may contain a subset of relevant properties that are temperature sensitive. PMID:8380658</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-520.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-520.pdf"><span id="translatedtitle">42 CFR 93.520 - The record.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative Actions Hearing... at any time. (d) The DAB may return original research records and other similar items to the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title42-vol1/pdf/CFR-2014-title42-vol1-sec93-509.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title42-vol1/pdf/CFR-2014-title42-vol1-sec93-509.pdf"><span id="translatedtitle">42 CFR 93.509 - Computation of time.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative Actions Hearing... respondent's request for a hearing, the ALJ may modify the time for the filing of any document or...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title42-vol1/pdf/CFR-2014-title42-vol1-sec93-520.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title42-vol1/pdf/CFR-2014-title42-vol1-sec93-520.pdf"><span id="translatedtitle">42 CFR 93.520 - The record.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative Actions Hearing... at any time. (d) The DAB may return original research records and other similar items to the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title42-vol1/pdf/CFR-2012-title42-vol1-sec93-520.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title42-vol1/pdf/CFR-2012-title42-vol1-sec93-520.pdf"><span id="translatedtitle">42 CFR 93.520 - The record.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative Actions Hearing... at any time. (d) The DAB may return original research records and other similar items to the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title42-vol1/pdf/CFR-2012-title42-vol1-sec93-508.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title42-vol1/pdf/CFR-2012-title42-vol1-sec93-508.pdf"><span id="translatedtitle">42 CFR 93.508 - Filing, forms, and service.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative... telephone number of the party on whose behalf the document or paper was filed, or the attorney of record for... the ALJ. (d) Proof of service. Each party filing a document or paper with the ALJ must also...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_22 --> <div id="page_23" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="441"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title42-vol1/pdf/CFR-2013-title42-vol1-sec93-520.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title42-vol1/pdf/CFR-2013-title42-vol1-sec93-520.pdf"><span id="translatedtitle">42 CFR 93.520 - The record.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>... STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative Actions Hearing... at any time. (d) The DAB may return original research records and other similar items to the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title42-vol1/pdf/CFR-2013-title42-vol1-sec93-508.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title42-vol1/pdf/CFR-2013-title42-vol1-sec93-508.pdf"><span id="translatedtitle">42 CFR 93.508 - Filing, forms, and service.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>... RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative... telephone number of the party on whose behalf the document or paper was filed, or the attorney of record for... the ALJ. (d) Proof of service. Each party filing a document or paper with the ALJ must also...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title42-vol1/pdf/CFR-2013-title42-vol1-sec93-509.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title42-vol1/pdf/CFR-2013-title42-vol1-sec93-509.pdf"><span id="translatedtitle">42 CFR 93.509 - Computation of time.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>... EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative Actions Hearing... respondent's request for a hearing, the ALJ may modify the time for the filing of any document or...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title42-vol1/pdf/CFR-2012-title42-vol1-sec93-509.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title42-vol1/pdf/CFR-2012-title42-vol1-sec93-509.pdf"><span id="translatedtitle">42 CFR 93.509 - Computation of time.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative Actions Hearing... respondent's request for a hearing, the ALJ may modify the time for the filing of any document or...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-520.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-520.pdf"><span id="translatedtitle">42 CFR 93.520 - The record.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative Actions Hearing... at any time. (d) The DAB may return original research records and other similar items to the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title42-vol1/pdf/CFR-2014-title42-vol1-sec93-508.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title42-vol1/pdf/CFR-2014-title42-vol1-sec93-508.pdf"><span id="translatedtitle">42 CFR 93.508 - Filing, forms, and service.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings of Research Misconduct and HHS Administrative... telephone number of the party on whose behalf the document or paper was filed, or the attorney of record for... the ALJ. (d) Proof of service. Each party filing a document or paper with the ALJ must also...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-313.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-313.pdf"><span id="translatedtitle">42 CFR 93.313 - Institutional investigation report.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 42 Public Health 1 2010-10-01 2010-10-01 false Institutional investigation report. 93.313 Section... Institutional investigation report. The final institutional investigation report must be in writing and include... already provided to <span class="hlt">ORI</span> with the inquiry report, include the institutional policies and procedures...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Simultaneous+AND+electrodes.&id=EJ742667','ERIC'); return false;" href="http://eric.ed.gov/?q=Simultaneous+AND+electrodes.&id=EJ742667"><span id="translatedtitle">Analysis of High-Frequency Electroencephalographic-Electromyographic Coherence Elicited by Speech and Oral Nonspeech Tasks in Parkinson's Disease</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Caviness, John N.; Liss, Julie M.; Adler, Charles; Evidente, Virgilio</p> <p>2006-01-01</p> <p>Purpose: Corticomuscular electroencephalographic-electromyographic (EEG-EMG) coherence elicited by speech and nonspeech oromotor tasks in healthy participants and those with Parkinson's disease (PD) was examined. Hypotheses were the following: (a) corticomuscular coherence is demonstrable between orbicularis <span class="hlt">oris</span> (OO) muscles' EMG and scalp EEG</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=emg&pg=6&id=EJ355589','ERIC'); return false;" href="http://eric.ed.gov/?q=emg&pg=6&id=EJ355589"><span id="translatedtitle">Speech-Muscle Visuomotor Tracking in Dysarthric and Nonimpaired Speakers.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>McClean, Michael D.; And Others</p> <p>1987-01-01</p> <p>Surface electrodes were used to describe the perioral reflexes in seven stutterers and five nonstutterers and electromyographic (EMG) recordings were obtained at electrode sites associated with the orbicularis <span class="hlt">oris</span> inferior muscle and the depressor labia inferior muscle. A difference was noted in the pattern of reflex response between the two</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=emg&pg=6&id=EJ355590','ERIC'); return false;" href="http://eric.ed.gov/?q=emg&pg=6&id=EJ355590"><span id="translatedtitle">Surface EMG Recording of the Perioral Reflexes: Preliminary Observations on Stutterers and Nonstutterers.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>McClean, Michael D.</p> <p>1987-01-01</p> <p>Surface electrodes were used to describe the perioral reflexes in seven stutterers and five nonstutterers and electromyographic (EMG) recordings were obtained at electrode sites associated with the orbicularis <span class="hlt">oris</span> inferior muscle and the depressor labia inferior muscle. A difference was noted in the pattern of reflex response between the two</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/EJ843614.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/EJ843614.pdf"><span id="translatedtitle">Teachers' Attitudes toward Students with Disabilities in Haiti</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Dupoux, Errol; Hammond, Helen; Ingalls, Lawrence; Wolman, Clara</p> <p>2006-01-01</p> <p>After conducting a thorough review of the state of inclusion of students with disabilities in Haiti, the authors present a study that investigates the attitudes of urban and rural teachers in Haiti toward inclusion. Participants were administered the Opinions Relative to Integration (<span class="hlt">ORI</span>) of Students with Disabilities instrument. Reliability of</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-08-28/pdf/2012-20889.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-08-28/pdf/2012-20889.pdf"><span id="translatedtitle">77 FR 51910 - Privacy Act, Exempt Record System</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-08-28</p> <p>... Proceedings, HHS/OPHS/<span class="hlt">ORI</span>'' System No. 09-37-0021 (59 FR 36717, July 19, 1994; revised most recently at 75 FR... these records will not be disclosed inappropriately (59 FR 36717, July 19, 1994). Likewise, FDA believes... 21, 1997 (62 FR 62466). The guidance document may be accessed at...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-406.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-406.pdf"><span id="translatedtitle">42 CFR 93.406 - Final HHS actions.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues... prescribed in 93.501, the <span class="hlt">ORI</span> finding of research misconduct is the final HHS action on the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-406.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-406.pdf"><span id="translatedtitle">42 CFR 93.406 - Final HHS actions.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues... prescribed in 93.501, the <span class="hlt">ORI</span> finding of research misconduct is the final HHS action on the...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-500.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-500.pdf"><span id="translatedtitle">42 CFR 93.500 - General policy.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... accordance with 45 CFR 76.845(c). (d) Where a proposed debarment or suspension action is based upon an <span class="hlt">ORI</span>... contest, and fact-finding required under the HHS debarment and suspension regulations at 45 CFR part 76, subparts H and G, respectively, and 48 CFR Subparts 9.4 and 309.4....</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://hdl.handle.net/2060/19870002218','NASA-TRS'); return false;" href="http://hdl.handle.net/2060/19870002218"><span id="translatedtitle">Combined ultraviolet studies of astronomical sources</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Baliunas, S. L.; Dupree, A. K.; Elvis, M.; Huchra, J. P.; Kenyon, S.; Raymond, J. C.</p> <p>1986-01-01</p> <p>Topics addressed include: Cygnus Loop; P Cygni profiles in dwarf novae; YY Gem; nova shells; HZ Herculis; activity cycles in cluster giants; Alpha <span class="hlt">Ori</span>; metal deficient giant stars; ultraviolet spectra of symbiotic stars detected by the Very Large Array; time variability in symbiotic stars; blue galaxies; and quasistellar objects with X-ray spectra.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/20581182','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/20581182"><span id="translatedtitle">Interdomain conjugal transfer of DNA from bacteria to archaea.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dodsworth, Jeremy A; Li, Lei; Wei, Shiping; Hedlund, Brian P; Leigh, John A; de Figueiredo, Paul</p> <p>2010-08-01</p> <p>Escherichia coli transforms the methanogenic archaeon Methanococcus maripaludis at frequencies ranging from 0.2 x 10(-6) to 2 x 10(-6) per recipient cell. Transformation requires cell-to-cell contact, <span class="hlt">ori</span>T, and tra functions, is insensitive to DNase I, and otherwise displays hallmarks of conjugation. PMID:20581182</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=257675','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=257675"><span id="translatedtitle">Modeling cotton (Gossypium spp) leaves and canopy using computer aided geometric design (CAGD)</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>The goal of this research is to develop a geometrically accurate model of cotton crop canopies for exploring changes in canopy microenvironment and physiological function with leaf structure. We develop an accurate representation of the leaves, including changes in three-dimensional folding and <span class="hlt">orie</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=207644','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=207644"><span id="translatedtitle">Homologous recombination plays minor role in excision of unit-length viral genomes from head-to-tail direct tandem repeats of porcine circovirus during DNA replication in Escherichia coli</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>Previously, we demonstrated that a theta-replicating bacterial plasmid containing 1.75 copies of genomic porcine circovirus (PCV) DNA in head-to-tail tandem (HTT) [a partial copy of PCV type 1 (PCV1), a complete copy of PCV type 2 (PCV2) and two origins of DNA replication (<span class="hlt">Ori</span>)] yielded three differ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6446638','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6446638"><span id="translatedtitle">Filamentary structure in the Orion molecular cloud</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Bally, J.; Stark, A.A.; Wilson, R.W.; Langer, W.D.</p> <p>1987-01-01</p> <p>A large-scale (C-13)O map (containing 33,000 spectra on a 1-arcmin grid) is presented for the giant molecular cloud located in the southern part of <span class="hlt">Ori</span> which contains the <span class="hlt">Ori</span> Nebula, NGC 1977, and the L1641 dark cloud complex. The overall structure of the cloud is filamentary, with individual features having a length up to 40 times their width. The northern portion of the cloud is compressed, dynamically relaxed, and supports massive star formation. In contrast, the southern part of the <span class="hlt">Ori</span> A cloud is diffuse, exhibits chaotic spatial and velocity structure, and supports only intermediate- to low-mass star formation. This morphology may be the consequence of the formation and evolution of the <span class="hlt">Ori</span> OB I association centered north of the molecular cloud. The entire cloud, in addition to the 5000-solar-mass filament containing both OMC-1 and OMC-2, exhibits a north-south velocity gradient. Implications of the observed cloud morphology for theories of molecular cloud evolution are discussed. 14 references.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_23 --> <div id="page_24" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="461"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=19870029352&hterms=Orion+Nebula&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3DOrion%2BNebula','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=19870029352&hterms=Orion+Nebula&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3DOrion%2BNebula"><span id="translatedtitle">Submillimeter polarization in the Orion Nebula</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Dragovan, M.</p> <p>1986-01-01</p> <p>Linear polarization measurements, obtained at 270 microns with the 0.91-m telescope of the NASA Kuyper Airborne Observatory in September 1983 and January and November 1984, are reported for three regions in <span class="hlt">Ori</span>. The large-scale magnetic field inferred from the measurements is shown to be uniform on the 0.4-pc scale of the beams.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=20060035776&hterms=models+young&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Dmodels%2Byoung','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=20060035776&hterms=models+young&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D70%26Ntt%3Dmodels%2Byoung"><span id="translatedtitle">8-13 Micron Spectroscopy of Young Stars</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Hanner, M. S.; Brooke, T. Y.; Tokunaga, A. T.</p> <p>1997-01-01</p> <p>We presen 8-13 meu spectra of 23 young stars acquired with the UKIRT CGS3 spectromere, including T Tauri, Herbig Ae/Be, and FU <span class="hlt">Ori</span> stars. Silicate emission and absorption features can generally be matched with the Trapezium emissivity, by employing simple models to account for optical depth effects.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://biospecimens.cancer.gov/meeting/brnsymposium/docs/Compton.pdf','NCI'); return false;" href="http://biospecimens.cancer.gov/meeting/brnsymposium/docs/Compton.pdf"><span id="translatedtitle">Microsoft PowerPoint - Compton</span></a></p> <p><a target="_blank" href="http://www.cancer.gov">Cancer.gov</a></p> <p></p> <p></p> <p>The Importance of High-Quality Biospecimens to the Research Enterprise: The Road to Molecular Medicine Carolyn C. Compton, M.D., Ph.D. Director, Office of Bioreposit <span class="hlt">ories</span> and Biospecimen Research Cancer: Our #1 Health Problem Cancer is the #1 killer</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=236864','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=236864"><span id="translatedtitle">The rolling-circle melting-pot model for porcine circovirus DNA replication</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>A stem-loop structure, formed by a pair of inverted repeats during DNA replication, is a conserved feature at the origin of DNA replication (<span class="hlt">Ori</span>) among plant and animal viruses, bacteriophages and plasmids that replicate their genomes via the rolling-circle replication (RCR) mechanism. Porcine circo...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2010ASPC..435..343H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2010ASPC..435..343H"><span id="translatedtitle">A Study of the Herbig Be Binary/FU Orionis Object Z CMa</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Hubrig, S.; Mikulášek, Z.; Schöller, M.; González, J.; Schütz, O.; Stelzer, B.; Zejda, M.; Šmelcer, L.; Brát, L.</p> <p>2010-12-01</p> <p>Z CMa is a young visual binary star with a FU <span class="hlt">Ori</span> companion. The primary star is in an outburst state since February 2008. We acquired photometric, spectroscopic, spectropolarimetric, and X-ray Chandra observations to study the mechanism causing violent outbursts in this kind of systems.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title29-vol1/pdf/CFR-2014-title29-vol1-sec31-2.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title29-vol1/pdf/CFR-2014-title29-vol1-sec31-2.pdf"><span id="translatedtitle">29 CFR 31.2 - Definitions.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-07-01</p> <p>... political subdivision, any public or private agency, institution, or organization, or any other entity, <span class="hlt">or...)(i</span>) An entire corporation, partnership, or other private organization, or an entire sole proprietorship (A) If assistance is extended to such corporation, partnership, private organization, or...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-517.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-517.pdf"><span id="translatedtitle">42 CFR 93.517 - The hearing.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... 42 Public Health 1 2011-10-01 2011-10-01 false The hearing. 93.517 Section 93.517 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title42-vol1/pdf/CFR-2012-title42-vol1-sec93-500.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title42-vol1/pdf/CFR-2012-title42-vol1-sec93-500.pdf"><span id="translatedtitle">42 CFR 93.500 - General policy.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... 42 Public Health 1 2012-10-01 2012-10-01 false General policy. 93.500 Section 93.500 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-518.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-518.pdf"><span id="translatedtitle">42 CFR 93.518 - Witnesses.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... 42 Public Health 1 2011-10-01 2011-10-01 false Witnesses. 93.518 Section 93.518 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title42-vol1/pdf/CFR-2012-title42-vol1-sec93-517.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title42-vol1/pdf/CFR-2012-title42-vol1-sec93-517.pdf"><span id="translatedtitle">42 CFR 93.517 - The hearing.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... 42 Public Health 1 2012-10-01 2012-10-01 false The hearing. 93.517 Section 93.517 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-500.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-500.pdf"><span id="translatedtitle">42 CFR 93.500 - General policy.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... 42 Public Health 1 2011-10-01 2011-10-01 false General policy. 93.500 Section 93.500 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title42-vol1/pdf/CFR-2013-title42-vol1-sec93-500.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title42-vol1/pdf/CFR-2013-title42-vol1-sec93-500.pdf"><span id="translatedtitle">42 CFR 93.500 - General policy.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>... accordance with 45 CFR 76.845(c). (d) Where a proposed debarment or suspension action is based upon an <span class="hlt">ORI</span>... contest, and fact-finding required under the HHS debarment and suspension regulations at 45 CFR part 76, subparts H and G, respectively, and 48 CFR Subparts 9.4 and 309.4....</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title42-vol1/pdf/CFR-2012-title42-vol1-sec93-518.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title42-vol1/pdf/CFR-2012-title42-vol1-sec93-518.pdf"><span id="translatedtitle">42 CFR 93.518 - Witnesses.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... 42 Public Health 1 2012-10-01 2012-10-01 false Witnesses. 93.518 Section 93.518 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest <span class="hlt">ORI</span> Findings...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title42-vol1/pdf/CFR-2014-title42-vol1-sec93-500.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title42-vol1/pdf/CFR-2014-title42-vol1-sec93-500.pdf"><span id="translatedtitle">42 CFR 93.500 - General policy.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... accordance with 45 CFR 76.845(c). (d) Where a proposed debarment or suspension action is based upon an <span class="hlt">ORI</span>... contest, and fact-finding required under the HHS debarment and suspension regulations at 45 CFR part 76, subparts H and G, respectively, and 48 CFR Subparts 9.4 and 309.4....</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=19750032221&hterms=beer+composition&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dbeer%2Bcomposition','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=19750032221&hterms=beer+composition&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D30%26Ntt%3Dbeer%2Bcomposition"><span id="translatedtitle">The silicon monoxide radical and the atmosphere of alpha Orionis</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Beer, R.; Lambert, D. L.; Sneden, C.</p> <p>1974-01-01</p> <p>We present new molecular constants, line positions, and transition probabilities for the first-overtone vibration-rotation bands in the X 1 Sigma+ electronic ground state of SiO, together with an estimate of the SiO abundance and silicon isotope ratios in the atmosphere of alpha <span class="hlt">Ori</span>.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6759804','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6759804"><span id="translatedtitle">Properties of SV40 large T antigen involved in the replication of SV40 DNA</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Mohr, I.J.</p> <p>1989-01-01</p> <p>The role of phosphorylation in regulating the biochemical properties of SV40 large T antigen (Tag) was analyzed. Treatment of purified Tag with calf intestinal alkaline phosphatase (CIAP) removed 80% of the {sup 32}P label. CIAP treated Tag displayed an increased ability to support SV40 DNA replication in vitro. This paralleled an activation of specific DNA binding to site II, an essential element within the SV40 origin of replication (<span class="hlt">ori</span>). The ATPase activity of dephosphorylated Tag remained unchanged. To evaluate the properties of Tag devoid of mammalian post translational modifications, a bacterial expression system was used. Purified E. coli Tag did not bind to site II, and therefore could not unwind <span class="hlt">ori</span> containing plasmids or efficiently replicate SV40 DNA in vitro. However, E. coli Tag functioned as a helicase, and bound to DNA fragments containing either site I or the wild type (wt) <span class="hlt">ori</span> in a manner identical to mammalian Tag. A single DNA binding domain is responsible for specific DNA binding to either of two different sites embedded in the SV40 <span class="hlt">ori</span>, and the intrinsic preference of full length Tag for either site I, or site II appears to be modulated by phosphorylation. Several Tag point mutants were examined in a series of assays which reflect partial biochemical reactions required for the in vitro replication of SV40 DNA.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4473185','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4473185"><span id="translatedtitle">In Vivo IS6110 Profile Changes in a Mycobacterium tuberculosis Strain as Determined by Tracking over 14 Years</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Milln-Lou, Mara Isabel; Otal, Isabel; Monforte, Mara Luisa; Vitoria, Mara Asuncin; Revillo, Mara Jos; Martn, Carlos</p> <p>2015-01-01</p> <p>Transposition and homologous recombination of IS6110 appear in Mycobacterium tuberculosis along in vivo sequential infections. These events were checked in different clones of a successful strain, M. tuberculosis Zaragoza, with the focus on a variant in which integration of a copy of IS6110 in the origin of replication (<span class="hlt">ori</span>C) region occurred. PMID:25948604</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=253782','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=253782"><span id="translatedtitle">Natural migration of rotylenchulus reniformis in a no-till cotton system</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>Rotylenchulus reniformis is the most economically damaging pathogen of cotton in Alabama. It is easily introduced into cotton fields via contaminated equipment and when present, is difficult and costly to control. A trial to monitor the natural migration of R. reniformis from an initial point of <span class="hlt">ori</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=241880','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=241880"><span id="translatedtitle">A comprehensive approach toward conserving Malus germplasm</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>The USDA-National Plant Germplasm System apple (Malus) collection has traditionally been conserved by maintaining orchards at the USDA-ARS Plant Genetic Resources Unit in Geneva, NY and cryopreserving dormant buds of clones. The orchard Malus collection includes hundreds of M. sieversii and M. <span class="hlt">orie</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015JAVSO..43...35P','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015JAVSO..43...35P"><span id="translatedtitle">UXOR Hunting among Algol Variables</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Poxon, M.</p> <p>2015-06-01</p> <p>The class of variable typified by UX Orionis (UXORs or UXors) are young stars characterised by aperiodic or semiperiodic fades from maximum. This has led to several of the class being formerly catalogued as Algol-type eclipsing binaries (EAs), which can show superficially similar light variations. With this in view, I propose a campaign to search for more UX <span class="hlt">Ori</span> type stars.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_24 --> <div id="page_25" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="481"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3318102','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3318102"><span id="translatedtitle">New insights into replication origin characteristics in metazoans</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Puy, Aurore; Rialle, Stphanie; Kaplan, Noam; Segal, Eran</p> <p>2012-01-01</p> <p>We recently reported the identification and characterization of DNA replication origins (<span class="hlt">Oris</span>) in metazoan cell lines. Here, we describe additional bioinformatic analyses showing that the previously identified GC-rich sequence elements form origin G-rich repeated elements (OGREs) that are present in 67% to 90% of the DNA replication origins from Drosophila to human cells, respectively. Our analyses also show that initiation of DNA synthesis takes place precisely at 160 bp (Drosophila) and 280 bp (mouse) from the OGRE. We also found that in most CpG islands, an OGRE is positioned in opposite orientation on each of the two DNA strands and detected two sites of initiation of DNA synthesis upstream or downstream of each OGRE. Conversely, <span class="hlt">Oris</span> not associated with CpG islands have a single initiation site. OGRE density along chromosomes correlated with previously published replication timing data. <span class="hlt">Ori</span> sequences centered on the OGRE are also predicted to have high intrinsic nucleosome occupancy. Finally, OGREs predict G-quadruplex structures at <span class="hlt">Oris</span> that might be structural elements controlling the choice or activation of replication origins. PMID:22373526</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-311.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title42-vol1/pdf/CFR-2011-title42-vol1-sec93-311.pdf"><span id="translatedtitle">42 CFR 93.311 - Investigation time limits.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... 42 Public Health 1 2011-10-01 2011-10-01 false Investigation time limits. 93.311 Section 93.311... time limits. (a) Time limit for completing an investigation. An institution must complete all aspects... sending the final report to <span class="hlt">ORI</span> under 93.315. (b) Extension of time limit. If unable to complete...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-311.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title42-vol1/pdf/CFR-2010-title42-vol1-sec93-311.pdf"><span id="translatedtitle">42 CFR 93.311 - Investigation time limits.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 42 Public Health 1 2010-10-01 2010-10-01 false Investigation time limits. 93.311 Section 93.311... time limits. (a) Time limit for completing an investigation. An institution must complete all aspects... sending the final report to <span class="hlt">ORI</span> under 93.315. (b) Extension of time limit. If unable to complete...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=231388','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=231388"><span id="translatedtitle">Recovery Plan for Phytophthora kernoviae Causing Bleeding Trunk Cankers, Leaf Blight and Stem Dieback in Trees and Shrubs</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>Phytophthora kernoviae, a recently described species of Phytophthora, is an invasive pathogen of forest trees and shrubs such as beech (Fagus sylvatica) and rhododendron (Rhododendron ponticum) that has become established in woodlands and public gardens in Cornwall, United Kingdom. Although the <span class="hlt">ori</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=194105','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=194105"><span id="translatedtitle">CONFIRMATION AND EFFICACY TESTS AGAINST CODLING MOTH AND ORIENTAL FRUIT MOTH IN PEACHES AND NECTARINES USING COMBINATION HEAT AND CONTROLLED ATMOSPHERE TREATMENTS</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>Two high-temperature, forced air treatments under controlled atmosphere conditions, were developed for control of all life stages of codling moth and oriental fruit moth infesting peaches and nectarines. These treatments were used in efficacy and confirmation tests to kill over 5,000 4th instar <span class="hlt">ori</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=311561','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=311561"><span id="translatedtitle">Registration of 'OL' peanut</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>OL peanut (experimental designation ARSOK-S140-1OL) is a high oleic Spanish-type peanut (Arachis hypogaea L. subsp. fastigiata var. vulgaris) that was cooperatively released by the USDA-ARS and the Oklahoma Agricultural Experiment Station in 2014. OL is the product of a Tamspan 90 X F435, the <span class="hlt">ori</span>...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1993A%26A...274L..29S','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1993A%26A...274L..29S"><span id="translatedtitle">Periodic Spectral Variations of THETA-1-ORIONIS-C</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Stahl, O.; Wolf, B.; Gang, T.; Gummersbach, C. A.; Kaufer, A.; Kovacs, J.; Mandel, H.; Szeifert, T.</p> <p>1993-07-01</p> <p>We have detected periodic spectral variations with a period of 15.43 0.03 days in the spectrum of ?l <span class="hlt">Ori</span> C, the brightest star in the Orion Trapezium and the main source of ionization of the Orion nebula (M 42).</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=192073','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=192073"><span id="translatedtitle">ROLLING-CIRCLE REPLICATION OF AN ANIMAL CIRCOVIRUS GENOME IN A THETA-REPLICATING BACTERIAL PLASMID IN ESCHERICHIA COLI</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>A bacterial plasmid containing 1.75 copies of double-stranded porcine circovirus (PCV) DNA in tandem [O.8 copy of PCV type 1 (PCV1), 0.95 copy of PCV type 2 (PCV2)] with two origins of DNA replication (<span class="hlt">Ori</span>) yielded three different DNA species when transformed into Escherichia coli: the input constru...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=company+AND+merger&pg=3&id=ED431969','ERIC'); return false;" href="http://eric.ed.gov/?q=company+AND+merger&pg=3&id=ED431969"><span id="translatedtitle">Change Processes in Organizations.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>1999</p> <p></p> <p>The first of the four papers in this symposium, "The Role of the Survey in the Assessment of an Organization for High Performance Redesign: A Case Study" (Teresa K. Moyers, <span class="hlt">Oris</span> T. Griffin), looks at how one company used a survey to analyze the way the social system currently is designed and operates. "Thriving on Change: An Organizational</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25536360','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25536360"><span id="translatedtitle">A literature review: addressing indigenous parental substance use and child welfare in Aotearoa: a Wh?nau Ora framework.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>McLachlan, Andre; Levy, Michelle; McClintock, Kahu; Tauroa, Roimata</p> <p>2015-01-01</p> <p>Parental substance use disorders (SUDs) for M?<span class="hlt">ori</span>, the indigenous people of Aotearoa/New Zealand and an ethnic minority, are considered to be contributors to adverse effects on outcomes for their children. This article offers a review of international and Aotearoa literature in regard to key considerations for M?<span class="hlt">ori</span> parents with SUDs who present to an Alcohol and Drug specialist for assessment and treatment. Factors to increase positive outcomes for M?<span class="hlt">ori</span> children of parents with SUDs are promoted. Effective adult AoD services provide support to parents with SUDs through comprehensive assessment and intervention plans that consider both individual and familial risk and protective factors. In this context, it is imperative that possible child welfare issues are identified early to ensure prevention or intervention. The AoD workforce must have the knowledge and skills to facilitate access to other relevant sectors, such as education, employment, and housing. An AoD workforce that is effective with M?<span class="hlt">ori</span> must not only have these abilities, but also have at least some basic knowledge and skills in Wh?nau Ora philosophy and Wh?nau-centered best practice. To address these processes, AoD specialist services need to acquire a set of knowledge and skills. These include increasing the knowledge and skills associated with the realities of lifestyles centered in low socioeconomic communities and co-occurring issues that contribute to poor health outcomes. To assist M?<span class="hlt">ori</span>, several key processes are proposed. This includes working in a Wh?nau-centered approach with Wh?nau as a collective entity, based on M?<span class="hlt">ori</span> foundations; understanding intergenerational dynamics; and endorsing a group capacity for self-determination. Research and training in Whanau ora philosophy and Wh?nau-centered best practices will be essential for developing an appropriate AoD workforce, which would provide the foundations for improving AoD service delivery for M?<span class="hlt">ori</span> parents with SUDs. PMID:25536360</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=20150023334&hterms=delta&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Ddelta','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=20150023334&hterms=delta&qs=N%3D0%26Ntk%3DAll%26Ntx%3Dmode%2Bmatchall%26Ntt%3Ddelta"><span id="translatedtitle">A Coordinated X-Ray and Optical Campaign of the Nearest Massive Eclipsing Binary, Delta Orionis Aa. I. Overview of the X-Ray Spectrum</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p>Corcoran, M. F.; Nicholas, J. S.; Pablo, H.; Shenar, T.; Pollock, A. M. T.; Waldron, W. L.; Moffat, A. F. J.; Richardson, N. D.; Russell, C. M. P.; Hamaguchi, K.; Leutenegger, M.; Gull, T. R.; Iping, R. C.</p> <p>2015-01-01</p> <p>We present an overview of four deep phase-constrained Chandra HETGS X-ray observations of Delta <span class="hlt">Ori</span> A. Delta <span class="hlt">Ori</span> A is actually a triple system that includes the nearest massive eclipsing spectroscopic binary, Delta <span class="hlt">Ori</span> Aa, the only such object that can be observed with little phase-smearing with the Chandra gratings. Since the fainter star, Delta <span class="hlt">Ori</span> Aa2, has a much lower X-ray luminosity than the brighter primary (Delta <span class="hlt">Ori</span> Aa1), Delta <span class="hlt">Ori</span> Aa provides a unique system with which to test the spatial distribution of the X-ray emitting gas around Delta <span class="hlt">Ori</span> Aa1 via occultation by the photosphere of, and wind cavity around, the X-ray dark secondary. Here we discuss the X-ray spectrum and X-ray line profiles for the combined observation, having an exposure time of nearly 500 ks and covering nearly the entire binary orbit. The companion papers discuss the X-ray variability seen in the Chandra spectra, present new space-based photometry and ground-based radial velocities obtained simultaneously with the X-ray data to better constrain the system parameters, and model the effects of X-rays on the optical and UV spectra. We find that the X-ray emission is dominated by embedded wind shock emission from star Aa1, with little contribution from the tertiary star Ab or the shocked gas produced by the collision of the wind of Aa1 against the surface of Aa2. We find a similar temperature distribution to previous X-ray spectrum analyses. We also show that the line half-widths are about 0.3-0.5 times the terminal velocity of the wind of star Aa1. We find a strong anti-correlation between line widths and the line excitation energy, which suggests that longer-wavelength, lower-temperature lines form farther out in the wind. Our analysis also indicates that the ratio of the intensities of the strong and weak lines of Fe XVII and Ne X are inconsistent with model predictions, which may be an effect of resonance scattering.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015ApJ...809..132C','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015ApJ...809..132C"><span id="translatedtitle">A Coordinated X-Ray and Optical Campaign of the Nearest Massive Eclipsing Binary, ? Orionis Aa. I. Overview of the X-Ray Spectrum</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Corcoran, M. F.; Nichols, J. S.; Pablo, H.; Shenar, T.; Pollock, A. M. T.; Waldron, W. L.; Moffat, A. F. J.; Richardson, N. D.; Russell, C. M. P.; Hamaguchi, K.; Huenemoerder, D. P.; Oskinova, L.; Hamann, W.-R.; Naz, Y.; Ignace, R.; Evans, N. R.; Lomax, J. R.; Hoffman, J. L.; Gayley, K.; Owocki, S. P.; Leutenegger, M.; Gull, T. R.; Hole, K. T.; Lauer, J.; Iping, R. C.</p> <p>2015-08-01</p> <p>We present an overview of four deep phase-constrained Chandra HETGS X-ray observations of ? <span class="hlt">Ori</span> A. Delta <span class="hlt">Ori</span> A is actually a triple system that includes the nearest massive eclipsing spectroscopic binary, ? <span class="hlt">Ori</span> Aa, the only such object that can be observed with little phase-smearing with the Chandra gratings. Since the fainter star, ? <span class="hlt">Ori</span> Aa2, has a much lower X-ray luminosity than the brighter primary (? <span class="hlt">Ori</span> Aa1), ? <span class="hlt">Ori</span> Aa provides a unique system with which to test the spatial distribution of the X-ray emitting gas around ? <span class="hlt">Ori</span> Aa1 via occultation by the photosphere of, and wind cavity around, the X-ray dark secondary. Here we discuss the X-ray spectrum and X-ray line profiles for the combined observation, having an exposure time of nearly 500 ks and covering nearly the entire binary orbit. The companion papers discuss the X-ray variability seen in the Chandra spectra, present new space-based photometry and ground-based radial velocities obtained simultaneously with the X-ray data to better constrain the system parameters, and model the effects of X-rays on the optical and UV spectra. We find that the X-ray emission is dominated by embedded wind shock emission from star Aa1, with little contribution from the tertiary star Ab or the shocked gas produced by the collision of the wind of Aa1 against the surface of Aa2. We find a similar temperature distribution to previous X-ray spectrum analyses. We also show that the line half-widths are about 0.3-0.5 times the terminal velocity of the wind of star Aa1. We find a strong anti-correlation between line widths and the line excitation energy, which suggests that longer-wavelength, lower-temperature lines form farther out in the wind. Our analysis also indicates that the ratio of the intensities of the strong and weak lines of Fe xvii and Ne x are inconsistent with model predictions, which may be an effect of resonance scattering.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1513511','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1513511"><span id="translatedtitle">Investigating the basis of substrate recognition in the pC221 relaxosome</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Caryl, Jamie A; Thomas, Christopher D</p> <p>2006-01-01</p> <p>The nicking of the origin of transfer (<span class="hlt">ori</span>T) is an essential initial step in the conjugative mobilization of plasmid DNA. In the case of staphylococcal plasmid pC221, nicking by the plasmid-specific MobA relaxase is facilitated by the DNA-binding accessory protein MobC; however, the role of MobC in this process is currently unknown. In this study, the site of MobC binding was determined by DNase I footprinting. MobC interacts with <span class="hlt">ori</span>T DNA at two directly repeated 9 bp sequences, mcb1 and mcb2, upstream of the <span class="hlt">ori</span>T nic site, and additionally at a third, degenerate repeat within the mobC gene, mcb3. The binding activity of the conserved sequences was confirmed indirectly by competitive electrophoretic mobility shift assays and directly by Surface Plasmon Resonance studies. Mutation at mcb2 abolished detectable nicking activity, suggesting that binding of this site by MobC is a prerequisite for nicking by MobA. Sequential site-directed mutagenesis of each binding site in pC221 has demonstrated that all three are required for mobilization. The MobA relaxase, while unable to bind to <span class="hlt">ori</span>T DNA alone, was found to associate with a MobC<span class="hlt">ori</span>T complex and alter the MobC binding profile in a region between mcb2 and the nic site. Mutagenesis of <span class="hlt">ori</span>T in this region defines a 7 bp sequence, sra, which was essential for nicking by MobA. Exchange of four divergent bases between the sra of pC221 and the related plasmid pC223 was sufficient to swap their substrate identity in a MobA-specific nicking assay. Based on these observations we propose a model of layered specificity in the assembly of pC221-family relaxosomes, whereby a common MobC:mcb complex presents the <span class="hlt">ori</span>T substrate, which is then nicked only by the cognate MobA. PMID:16689804</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3502153','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3502153"><span id="translatedtitle">Life and Living in Advanced Age: A Cohort Study in New Zealand -Te Puāwaitanga o Nga Tapuwae Kia Ora Tonu, LiLACS NZ: Study protocol</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2012-01-01</p> <p>Background The number of people of advanced age (85 years and older) is increasing and health systems may be challenged by increasing health-related needs. Recent overseas evidence suggests relatively high levels of wellbeing in this group, however little is known about people of advanced age, particularly the indigenous Mā<span class="hlt">ori</span>, in Aotearoa, New Zealand. This paper outlines the methods of the study Life and Living in Advanced Age: A Cohort Study in New Zealand. The study aimed to establish predictors of successful advanced ageing and understand the relative importance of health, frailty, cultural, social & economic factors to successful ageing for Mā<span class="hlt">ori</span> and non-Mā<span class="hlt">ori</span> in New Zealand. Methods/design A total population cohort study of those of advanced age. Two cohorts of equal size, Mā<span class="hlt">ori</span> aged 80–90 and non-Mā<span class="hlt">ori</span> aged 85, oversampling to enable sufficient power, were enrolled. A defined geographic region, living in the Bay of Plenty and Lakes District Health Board areas of New Zealand, defined the sampling frame. Rūnanga (Mā<span class="hlt">ori</span> tribal organisations) and Primary Health Organisations were subcontracted to recruit on behalf of the University. Measures - a comprehensive interview schedule was piloted and administered by a trained interviewer using standardised techniques. Socio-demographic and personal history included tribal affiliation for Mā<span class="hlt">ori</span> and participation in cultural practices; physical and psychological health status used standardised validated research tools; health behaviours included smoking, alcohol use and nutrition risk; and environmental data included local amenities, type of housing and neighbourhood. Social network structures and social support exchanges are recorded. Measures of physical function; gait speed, leg strength and balance, were completed. Everyday interests and activities, views on ageing and financial interests complete the interview. A physical assessment by a trained nurse included electrocardiograph, blood pressure, hearing and vision, anthropometric measures, respiratory function testing and blood samples. Discussion A longitudinal study of people of advanced age is underway in New Zealand. The health status of a population based sample of older people will be established and predictors of successful ageing determined. PMID:22747503</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2009ApJ...701.1464H','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2009ApJ...701.1464H"><span id="translatedtitle">Texes Observations of M Supergiants: Dynamics and Thermodynamics of Wind Acceleration</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Harper, Graham M.; Richter, Matthew J.; Ryde, Nils; Brown, Alexander; Brown, Joanna; Greathouse, Thomas K.; Strong, Shadrian</p> <p>2009-08-01</p> <p>We have detected [Fe II] 17.94 ?m and 24.52 ?m emission from a sample of M supergiants (? Cep, ? Sco, ? <span class="hlt">Ori</span>, CE Tau, AD Per, and ? Her) using the Texas Echelon Cross Echelle Spectrograph on NASA's Infrared Telescope Facility. These low opacity emission lines are resolved at R sime 50, 000 and provide new diagnostics of the dynamics and thermodynamics of the stellar wind acceleration zone. The [Fe II] lines, from the first excited term (a 4 F), are sensitive to the warm plasma where energy is deposited into the extended atmosphere to form the chromosphere and wind outflow. These diagnostics complement previous Kuiper Airborne Observatory and Infrared Space Observatory observations which were sensitive to the cooler and more extended circumstellar envelopes. The turbulent velocities of V turb sime 12-13 km s-1 observed in the [Fe II] a 4 F forbidden lines are found to be a common property of our sample, and are less than that derived from the hotter chromospheric C II] 2325 lines observed in ? <span class="hlt">Ori</span>, where V turb sime 17-19 km s-1. For the first time, we have dynamically resolved the motions of the dominant cool atmospheric component discovered in ? <span class="hlt">Ori</span> from multiwavelength radio interferometry by Lim et al. Surprisingly, the emission centroids are quite Gaussian and at rest with respect to the M supergiants. These constraints combined with model calculations of the infrared emission line fluxes for ? <span class="hlt">Ori</span> imply that the warm material has a low outflow velocity and is located close to the star. We have also detected narrow [Fe I] 24.04 ?m emission that confirms Fe II is the dominant ionization state in ? <span class="hlt">Ori</span>'s extended atmosphere.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/18067922','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/18067922"><span id="translatedtitle">Remodeling of the human papillomavirus type 11 replication origin into discrete nucleoprotein particles and looped structures by the E2 protein.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sim, Jeonggu; Ozgur, Sezgin; Lin, Biing Yuan; Yu, Jei-Hwa; Broker, Thomas R; Chow, Louise T; Griffith, Jack</p> <p>2008-01-25</p> <p>The human papillomavirus (HPV) DNA replication origin (<span class="hlt">ori</span>) shares a common theme with many DNA control elements in having multiple binding sites for one or more proteins spaced over several hundreds of base pairs. The HPV type 11 <span class="hlt">ori</span> spans 103 bp and contains three palindromic E2 binding sites (E2BS-2, E2BS-3, and E2BS-4) for the dimeric E2 <span class="hlt">ori</span> binding protein. These sites are separated by 64 and 3 bp. E2BS-1 is located 288 bp upstream of E2BS-2 and is not required for efficient transient or cell-free replication. In this study, electron microscopy was used to visualize complexes of HPV-11 DNA <span class="hlt">ori</span> bound by purified E2 protein. DNA containing only E2BS-2 showed a single E2 dimer bound. DNA containing E2BS-3 and E2BS-4 showed two side-by-side E2 dimers, while DNA containing E2BS-2, E2BS-3, and E2BS-4 exhibited a large disk/ring-shaped protein particle bound, indicating that the DNA had been remodeled into a discrete complex, likely containing an E2 hexamer. With all four binding sites present, up to 27% of the DNA molecules were arranged into loops by E2, the majority of which spanned E2BS-1 and one of the other three sites. Studies on the dependence of looping on salt, ATP, and DTT using full-length E2 and an E2 protein containing only the carboxyl-terminal DNA binding and protein dimerization domain suggest that looping is dependent on the N-terminal domain and factors that may affect the manner in which E2 scans DNA for binding sites. The role of these structures in the modeling and regulation of the HPV-11 <span class="hlt">ori</span> is discussed. PMID:18067922</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=216426','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=216426"><span id="translatedtitle">Trimethoprim-Produced F-Specific Insertion Mutations in Escherichia coli K-12</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Mukhopadhyay, Pradip; Palchaudhuri, Sunil</p> <p>1982-01-01</p> <p>Besides producing thymine-requiring mutants (thy), trimethoprim (TMP) cured the mini-ColE1 replicon pML21 at an appreciable frequency. The cured Escherichia coli K-12 cells behaved like polA mutants by failing to support the stable maintenance of the ColE1 plasmid. The mini-F replicon pSC138, which was lacking all three insertion sequences (IS3, γδ, and IS2) normally used for F-specific integration and excision, was not cured by TMP. Instead, it integrated into specific regions of the E. coli chromosome and thus caused auxotrophic mutations in operons which were always localized on either side of <span class="hlt">ori</span>C (origin of chromosomal replication). The incompatibility and replication functions of the integrated plasmid in auxotrophs were retained, and the plasmid DNAs recovered from spontaneously occurring revertants did not show any alterations in their contour lengths as determined by electron microscopy. The F replicon (fragment 5) contained in plasmid pSC138 carried two origins of replication, the primary origin, <span class="hlt">ori</span>V1 at 42.6F and the secondary origin, <span class="hlt">ori</span>V2, at 44.1F. Another mini-F plasmid pMF21, deleted of the primary origin of replication (<span class="hlt">ori</span>V1), was still capable of autonomous replication but failed to integrate onto the chromosome after TMP treatment. Furthermore, the composite plasmid pRS5, which normally uses only the replication origin and functions of the pSC101 component, was also insensitive to TMP. On the basis of these results, we propose a new scheme of F integration via the functional <span class="hlt">ori</span>V1 and suggest the involvement of a similar mechanism in the formation of Hfr strains by integrative suppression. PMID:6279570</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015EPSC...10..673M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015EPSC...10..673M"><span id="translatedtitle">EU-FP7-iMARS: analysis of Mars multi-resolution images using auto-coregistration, data mining and crowd source techniques: A Mid-term Report</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Muller, J.-P.; Yershov, V.; Sidiropoulos, P.; Gwinner, K.; Willner, K.; Fanara, L.; Waelisch, M.; van Gasselt, S.; Walter, S.; Ivanov, A.; Cantini, F.; Morley, J. G.; Sprinks, J.; Giordano, M.; Wardlaw, J.; Kim, J.-R.; Chen, W.-T.; Houghton, R.; Bamford, S.</p> <p>2015-10-01</p> <p>Understanding the role of different solid surface formation processes within our Solar System is one of the fundamental goals of planetary science research. There has been a revolution in planetary surface observations over the last 8 years, especially in 3D imaging of surface shape (down to resolutions of 10s of cms) and subsequent terrain correction of imagery from orbiting spacecraft. This has led to the potential to be able to overlay different epochs back to the mid-1970s. Within iMars, a processing system has been developed to generate 3D Digital Terrain Models (DTMs) and corresponding OrthoRectified Images (<span class="hlt">ORIs</span>) fully automatically from NASA MRO HiRISE and CTX stereo-pairs which are coregistered to corresponding HRSC <span class="hlt">ORI</span>/DTMs. In parallel, iMars has developed a fully automated processing chain for co-registering level-1 (EDR) images from all previous NASA orbital missions to these HRSC <span class="hlt">ORIs</span> and in the case of HiRISE these are further co-registered to previously co-registered CTX-to-HRSC <span class="hlt">ORIs</span>. Examples will be shown of these multi-resolution <span class="hlt">ORIs</span> and the application of different data mining algorithms to change detection using these co-registered images. iMars has recently launched a citizen science experiment to evaluate best practices for future citizen scientist validation of such data mining processed results. An example of the iMars website will be shown along with an embedded Version 0 prototype of a webGIS based on OGC standards.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1993A%26AS..101..127F','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1993A%26AS..101..127F"><span id="translatedtitle">The Orion Radio Zoo Revisited - Source Variability</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Felli, M.; Taylor, G. B.; Catarzi, M.; Churchwell, E.; Kurtz, S.</p> <p>1993-10-01</p> <p>The core of the Orion nebula has been monitored with the VLA in the A and B configurations at 5 and 15 GHz over a period of 7 months. A region of 0.2 pc centered on the Trapezium cluster was imaged about every two weeks at both frequencies. The goal was to study possible temporal variations of flux density and spectral index of a large number of very compact radio sources near the Trapezium cluster. The binary system θ1<span class="hlt">Ori</span> A is the most variable source in the sample. Although some modulation of emission with orbital phase might be present, the main source of variability appears to be intrinsic and not related to orbital phase; possibly flaring activity on the surface of the T Tauri companion. All of the other radio sources are classified as thermal or nonthermal depending on their variability, spectral index, angular size, and optical identification. The thermal sources are clustered close to θ1<span class="hlt">Ori</span> C (with the exception of BN and IRc2). We suggest that the thermal sources near θ1<span class="hlt">Ori</span> C that are coincident with visible stars may be photoionized envelopes (due to UV radiation from θ1<span class="hlt">Ori</span> C) of accretion disks around low mass stars. In the spirit of Garay (1987), we refer to these objects as EIDERS=Externally Ionized (accretion) Disks in the Environs of Radiation Sources which O'Dell et al. (1993) call PROPLYDS. The thermal radio sources that are not coincident with visible stars are probably neutral condensations whose outer envelopes are ionized by UV radiation from θ1<span class="hlt">Ori</span> C. The latter are sometimes referred to as PIGs (partially ionized globules). The nonthermal sources are scattered over a larger area. Premain sequence flaring activity is proposed as the source of radio emission. For the brightest nonthermal sources a correlation between spectral index and flux density is found, which can be explained qualitatively by synchrotron emission in a magnetic loop.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/21319566','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/21319566"><span id="translatedtitle">TEXES OBSERVATIONS OF M SUPERGIANTS: DYNAMICS AND THERMODYNAMICS OF WIND ACCELERATION</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Harper, Graham M.; Richter, Matthew J.; Ryde, Nils; Brown, Alexander; Brown, Joanna; Greathouse, Thomas K.; Strong, Shadrian</p> <p>2009-08-20</p> <p>We have detected [Fe II] 17.94 {mu}m and 24.52 {mu}m emission from a sample of M supergiants ({mu} Cep, {alpha} Sco, {alpha} <span class="hlt">Ori</span>, CE Tau, AD Per, and {alpha} Her) using the Texas Echelon Cross Echelle Spectrograph on NASA's Infrared Telescope Facility. These low opacity emission lines are resolved at R {approx_equal} 50, 000 and provide new diagnostics of the dynamics and thermodynamics of the stellar wind acceleration zone. The [Fe II] lines, from the first excited term (a {sup 4} F), are sensitive to the warm plasma where energy is deposited into the extended atmosphere to form the chromosphere and wind outflow. These diagnostics complement previous Kuiper Airborne Observatory and Infrared Space Observatory observations which were sensitive to the cooler and more extended circumstellar envelopes. The turbulent velocities of V{sub turb} {approx_equal} 12-13 km s{sup -1} observed in the [Fe II] a {sup 4} F forbidden lines are found to be a common property of our sample, and are less than that derived from the hotter chromospheric C II] 2325 A lines observed in {alpha} <span class="hlt">Ori</span>, where V{sub turb} {approx_equal} 17-19 km s{sup -1}. For the first time, we have dynamically resolved the motions of the dominant cool atmospheric component discovered in {alpha} <span class="hlt">Ori</span> from multiwavelength radio interferometry by Lim et al. Surprisingly, the emission centroids are quite Gaussian and at rest with respect to the M supergiants. These constraints combined with model calculations of the infrared emission line fluxes for {alpha} <span class="hlt">Ori</span> imply that the warm material has a low outflow velocity and is located close to the star. We have also detected narrow [Fe I] 24.04 {mu}m emission that confirms Fe II is the dominant ionization state in {alpha} <span class="hlt">Ori</span>'s extended atmosphere.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_25 --> <center> <div class="footer-extlink text-muted"><small>Some links on this page may take you to non-federal websites. 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