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Sample records for lhmus lars briggs

  1. "The Snowman" by Raymond Briggs.

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2003-01-01

    Discusses the classic children's book "The Snowman," by Raymond Briggs, and lists connections to the book in different formats; extension ideas; other picture books that feature snow; information books about snow; videos; a CD-ROM; Web sites related to the book; and Web sites with information about snow. (LRW)

  2. Myers-Briggs typology and Jungian individuation.

    PubMed

    Myers, Steve

    2016-06-01

    Myers-Briggs typology is widely seen as equivalent to and representative of Jungian theory by the users of the Myers-Briggs Type Indicator (MBTI) and similar questionnaires. However, the omission of the transcendent function from the theory, and the use of typological functions as its foundation, has resulted in an inadvertent reframing of the process of individuation. This is despite some attempts to integrate individuation and typology, and reintroduce the transcendent function into Myers-Briggs theory. This paper examines the differing views of individuation in Myers-Briggs and Jungian theory, and some of the challenges of reconciling those differences, particularly in the context of normality. It proposes eight principles, drawn mainly from Jungian and classical post-Jungian work, that show how individuation as a process can be integrated with contemporary Myers-Briggs typology. These principles show individuation as being a natural process that can be encouraged outside of the analytic process. They make use of a wide range of opposites as well as typological functions, whilst being centred on the transcendent function. Central to the process is the alchemical image of the caduceus and a practical interpretation of the axiom of Maria, both of which Jung used to illustrate the process of individuation. PMID:27192365

  3. The Myers-Briggs Type of College Student Leaders.

    ERIC Educational Resources Information Center

    Darst, Kimberly Vess

    2001-01-01

    Determined the Myers-Briggs type for 149 undergraduate students holding leadership positions in student organizations. Found that college student leaders tent to be Extraverted, Sensing, Thinking, and Judging on the Myers-Briggs Type Indicator. (EV)

  4. 75 FR 10318 - Briggs & Stratton Power Products Group, LLC., Home Power Division, a Subsidiary of Briggs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    ... Federal Register on February 16, 2010 (75 FR 7036). At the request of the State agency and a company... Power Division, Schweiger Warehouse, a Subsidiary of Briggs & Stratton Corporation Including On-Site... under the Home Power Division of the subject firm; Schweiger Warehouse, Jefferson, Wisconsin and...

  5. Lars, the Oracle

    NASA Astrophysics Data System (ADS)

    Careri, Giorgio

    Lars Onsager was known for his obscure but correct predictions in several fields of science. Some scientific events, particularly in the field of superfluidity, are recollected here by one of his old friends.

  6. Myers-Briggs Type Indicator and Dental School Performance.

    ERIC Educational Resources Information Center

    Jones, Anne C.; Courts, Frank J.; Sandow, Pamela L.; Watson, Ronald E.

    1997-01-01

    A study, using Myers-Briggs Type Indicators, of 256 dental students in four classes found introverted students performed better on the National Dental Board Examinations but had progressively lower class rank over four years and experienced more major academic difficulties. Judging and sensing students had higher rank than perceiving and intuitive…

  7. Credible Immigration Policy Reform: A Response to Briggs

    ERIC Educational Resources Information Center

    Orrenius, Pia M.; Zavodny, Madeline

    2012-01-01

    The authors agree with Vernon M. Briggs, Jr., that U.S. immigration policy has had unexpected consequences. The 1965 immigration reforms led to unanticipated chain migration from developing countries whereas the 1986 Immigration Reform and Control Act failed to slow unauthorized immigration. The result is a large foreign-born population with…

  8. An Assessment of the Myers-Briggs Type Indicator

    ERIC Educational Resources Information Center

    Carlyn, Marcia

    1977-01-01

    The Myers Briggs Type Indicator is a self-report inventory developed to measure variables in Carl Jung's personality typology. The four personality scales measured by the instrument, and the scoring process are described, and an extensive review of the intercorrelation, reliability, and validity research is presented. (Author/MV)

  9. Myers-Briggs Type Inventory Personality Preferences and Academic Performance.

    ERIC Educational Resources Information Center

    Lowenthal, Werner; Meth, Hilda

    1989-01-01

    A study to determine if there are any relationships between the Myers-Briggs Type Inventory personality preferences and academic performance in schools of pharmacy is discussed. Differences in academic performance that could be related to gender are reported. (Author/MLW)

  10. Myers-Briggs® Preferences and Academic Success in the First College Semester

    ERIC Educational Resources Information Center

    Sanborn, Debra K.

    2013-01-01

    This research examined aspects of Myers-Briggs® preferences and academic success in the first college semester. Academic aptitude as measured by precollege characteristics of ACT and class rank, academic performance during the first semester of college, and Myers-Briggs preference were analyzed for their significance within a learning community at…

  11. Self-Selection Patterns of College Roommates as Identified by the Myers-Briggs Type Indicator.

    ERIC Educational Resources Information Center

    Anchors, W. Scott; Hale, John, Jr.

    1985-01-01

    Investigated patterns and processes by which students (N=422) made unassisted roommate pairings within residence halls using the Myers-Briggs Type Indicator. Results indicated introverts, intuitives, feelers, and perceivers each tended to self-select. (BL)

  12. Lar gibbon (Hylobates lar) great call reveals individual caller identity.

    PubMed

    Terleph, Thomas A; Malaivijitnond, S; Reichard, U H

    2015-07-01

    Gibbons (family Hylobatidae) produce loud, elaborate vocalizations (songs), often in well-coordinated male/female duets. The female's great call, the most conspicuous phrase of the gibbon vocal repertoire, functions primarily to mediate territorial defense. Despite the fact that lar gibbons (Hylobates lar) are the most widely distributed and well researched hylobatid species and produce a rich vocal repertoire, the individual-specificity of their great calls has not previously been quantified. In addition, spectral and temporal features of notes occurring at specific locations within the lar great call have not been described. Here we provide such a description, and test the hypothesis that great calls are statistically discriminable between a large sample of individual callers. We compared recordings of great calls from 14 wild lar females in Khao Yai National Park, Thailand. Our analyses of principal components derived from spectral and temporal measures, as well as spectrograms from the entire great call, indicate that acoustic variation is sufficient to allow identification of individual callers (83.5% discriminability based on principal components, and inter-individual call variation exceeding intra-individual variation in overall spectrogram). These vocalizations potentially allow individual recognition of animals. PMID:25800578

  13. The LArIAT Experiment at Fermilab

    NASA Astrophysics Data System (ADS)

    Nutini, Irene; LArIAT Collaboration

    2016-02-01

    The LArIAT experiment at Fermilab is part of the International Neutrino program recently approved in the US. LArIAT aims to measure the main features of charged particles interactions in argon in the energy range (0.2 - 2.0 GeV) corresponding to the energy spectrum of the same particles when produced in a neutrino-argon interaction (neutrino energies of few GeV) typical of the short- and long-baseline neutrino beams of the Neutrino Program. Data collected from the 1 st Run are being analyzed for both Physics studies and a technical characterization of the scintillation light collection system. Two analysis topics are reported: the method developed for charged pion cross section measurement, based on the specific features of the LArTPC, and the development and test of the LArIAT custom-designed cold front-end electronics for SiPM devices to collect LAr scintillation light.

  14. The Influence of Hemispheric Dominance on Scores of the Myers-Briggs Type Indicator.

    ERIC Educational Resources Information Center

    Hartman, Steve E.; And Others

    1997-01-01

    Results for 75 medical students and 248 undergraduates suggest that the Myers-Briggs Type Indicator appears to sample only 3 bipolar personality dimensions rather than the 4 that the use of "type tables" implies. One of these dimensions shares substantial variance with the cognitive model of hemispheric dominance. (SLD)

  15. Myers-Briggs Attitude Typology: The Influence of Birth Order with Other Family Variables.

    ERIC Educational Resources Information Center

    Stansbury, Virginia K.; Coll, Kenneth M.

    1998-01-01

    Investigates the influence of birth order with parenting style, age spacing, gender, and socioeconomic status on the Myers-Briggs attitude scales of Extroversion/Introversion and Judging/Perceiving. Results indicate that age spacing interacted with birth order to influence Extroversion/Introversion scores. Parenting style and gender interacted…

  16. Using the Myers-Briggs Type Indicator in the Social Work Classroom.

    ERIC Educational Resources Information Center

    Aviles, Christopher B.

    The Myers-Briggs Type Indicator (MBTI) is one of the most popular measures of personality available today and has been taken by over 12 million people. The MBTI has been successfully utilized for personal and marriage counseling, conflict and stress management, and understanding learning styles. It is perfect for the social work classroom because…

  17. Eysenck Personality Questionnaire and Jungian Myers-Briggs Type Indicator Correlation of Extraversion-Introversion

    ERIC Educational Resources Information Center

    Steele, Robert S.; Kelly, Thomas J.

    1976-01-01

    C. G. Jung and H. J. Eysenck developed concepts of extraversion-introversion from radically different theoretical orientations. It is hypothesized that given the methods and content similarity of the Eysenck Personality Questionnaire and the Myers-Briggs Type Indicator. Extraversion-Introversion scales of the inventories will be significantly…

  18. Survey of Librarians Using the Myers-Briggs Type Indicator (Form G Self-Scorable).

    ERIC Educational Resources Information Center

    Johns, Alan

    A survey conducted in February 1990 asked 100 librarians to respond to a mailed Myers-Briggs Type Indicator (MBTI), a widely used personality survey that determines Jungian personality types. The results of the MBTI can be applied to building work teams in the library. Forty-eight librarians responded to the survey. Their responses were tallied…

  19. The Myers-Briggs Type Indicator and the Teaching-Learning Process.

    ERIC Educational Resources Information Center

    McCaulley, Mary H.

    The Myers-Briggs Type Indicator (MBTI) was developed specifically to make possible the implementation of Carl Jung's theory of type and is concerned mainly with conscious elements of the personality. It assumes that to function well, an individual must have a well-developed system for perception and a well-developed system for making decisions or…

  20. South Dakota State University's Library: A History. Hilton M. Briggs Library Occasional Paper Number 1.

    ERIC Educational Resources Information Center

    Brown, Philip

    Tracing the history of South Dakota State University's Hilton M. Briggs Library over the past 102 years, this occasional paper describes the development of what is now the largest library (over 1.1 million total pieces) in the South Dakota Library Network from its inception as part of a small land grant college. Administrative eras are reviewed,…

  1. The "imprisoned illness:" motor tic disorder in Rainer Maria Rilke's Notebooks of Malte Laurids Brigge.

    PubMed

    Cavanna, Andrea Eugenio; Pattumelli, Maria Grazia; Quarto, Tiziana; Ali, Fizzah; Rickards, Hugh

    2010-09-15

    Rainer Maria Rilke's novel The Notebooks of Malte Laurids Brigge contains a reference of interest for the catalog of literary portrayals of tiqueurs. In this article, we report his description of a Parisian character displaying multiple motor tic symptoms, along with a brief commentary. PMID:20669278

  2. Teacher's Myers-Briggs Personality Profiles: Identifying Effective Teacher Personality Traits

    ERIC Educational Resources Information Center

    Rushton, Stephen; Morgan, Jackson; Richard, Michael

    2007-01-01

    The Myers-Briggs Type Inventory (MBTI) and Beiderman Risk Taking (BRT) scale were administered to 58 teachers living in the state of Florida, USA. These teachers are considered part of prestigious group of educators who were nominated into the Florida League of Teachers by their superintendents/directors. Descriptive data includes frequency and…

  3. Differences in Myers-Briggs Personality Types among High School Band, Orchestra, and Choir Members

    ERIC Educational Resources Information Center

    MacLellan, Christin Reardon

    2011-01-01

    The purpose of this study was to explore personality type differences among high school band, string orchestra, and choir students according to ensemble membership. Participants (N = 355) were high school students who had participated in their school's band, orchestra, or choir for 1 year or more. The author administered the Myers-Briggs Type…

  4. Opposition from Christians to Myers-Briggs Personality Typing: An Analysis and Evaluation

    ERIC Educational Resources Information Center

    Lloyd, John B.

    2007-01-01

    Myers-Briggs personality typing is widely used in the Christian church as an aid to individual self-understanding and spiritual formation. However, some Christian leaders have expressed doubt about its validity in understanding human personality and also opposition to its use in nurturing spiritual growth. The aim of the work reported was to…

  5. Enhancing Student Team Effectiveness: Application of Myers-Briggs Personality Assessment in Business Courses

    ERIC Educational Resources Information Center

    Amato, Christie H.; Amato, Louis H.

    2005-01-01

    This article examines the relationship between student perceptions of team learning experience and communication style. Student group learning perceptions were evaluated and team communication style was measured using dyads derived from Myers-Briggs personality profiles. Groups containing similar personalities were classified as compatible,…

  6. Personality Characteristics of South Korean Students with Visual Impairments Using the Myers-Briggs Type Indicator

    ERIC Educational Resources Information Center

    Bak, Sunhi

    2012-01-01

    Introduction: The study presented here was designed to determine whether there were significant differences in the frequency and preference scores of personality functions and the frequency of personality types, as measured by the Myers-Briggs Type Indicator (MBTI), by gender, school level, and level of visual function, of students with visual…

  7. Liquor Activity Reduction (LAR) Programme - 12397

    SciTech Connect

    Pether, Colin; Carrol, Phil; Birkett, Eddie; Kibble, Matthew

    2012-07-01

    Waste material from the reprocessing of irradiated fuel has been stored under water for several decades leading to the water becoming highly radioactive. As a critical enabler to the decommissioning strategy for the Sellafield site, the Liquor Activity Reduction (LAR) programme has been established to provide a processing route for this highly radioactive liquor. This paper reviews the progress that has been made since the start of routine LAR transfer cycles (July 2010) and follows on from the earlier paper presented at WM2011. The paper focuses on the learning from the first full year of routine LAR transfer cycles and the application of this learning to the wider strategies for the treatment of further radioactive liquid effluents on the Sellafield site. During this period over 100,000 Curies of radioactivity has been safely removed and treated. The past year has witnessed the very successful introduction of the LAR programme. This has lead to hazard reduction at MSSS and demonstration that the SIXEP facility can meet the significantly increased challenge that the LAR programme represents. Part of the success has been the ability to predict and deliver a realistic production schedule with the availability of the MSSS, EDT and SIXEP facilities being central to this. Most importantly, the LAR programme has been successful in bringing together key stakeholders to deliver this work while integrating with the existing, day to day, demands of the Sellafield site. (authors)

  8. Over-representation of Myers Briggs Type Indicator introversion in social phobia patients.

    PubMed

    Janowsky, D S; Morter, S; Tancer, M

    2000-01-01

    The purpose of this study is to profile the personalities of patients with social phobia. Sixteen patients with social phobia were compared with a normative population of 55,971, and with 24 hospitalized Major Depressive Disorder inpatients, using the Myers Briggs Type Indicator. The Myers Briggs Type Indicator, a popular personality survey, divides individuals into eight categories: Extroverts versus Introverts, Sensors versus Intuitives, Thinkers versus Feelers, and Judgers versus Perceivers. Social phobia patients were significantly more often Introverts (93.7%) than were subjects in the normative population (46.2%). In addition, using continuous scores, the social phobia patients scored as significantly more introverted than did the patients with Major Depressive Disorder, who also scored as Introverted. Introversion is a major component of social phobia, and this observation may have both etiological and therapeutic significance. PMID:10875053

  9. The liquid annular reactor system (LARS) propulsion

    SciTech Connect

    Maise, G.; Lazareth, O.W.; Horn, F.; Powell, J.R.; Ludewig, H. ); Lenard, R.X. )

    1991-01-05

    A new concept for very high specific impulse ({gt}2000 seconds) direct nuclear propulsion is described. The concept, termed LARS (Liquid Annular Reactor System) uses liquid nuclear fuel elements to heat hydrogen propellant to very high temperatures ({similar to}6000 K). Operating pressure is moderate ({similar to}10 atm), with the result that the outlet hydrogen is virtually 100% dissociated to monatomic H. The molten fuel is contained in a solid container of its own material, which is rotated to stabilize the liquid layer by centripetal force. LARS reactor designs are described, together with neutronic and thermal-hydraulic analyses. Power levels are on the order of 200 megawatts. Typically, LARS designs use 7 rotating fuel elements, are beryllium moderated and have critical radii of {similar to}100 cm (core L/D{approx}1.5).

  10. Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion.

    PubMed

    Desguin, Benoît; Soumillion, Patrice; Hols, Pascal; Hausinger, Robert P

    2016-05-17

    The lactate racemase enzyme (LarA) of Lactobacillus plantarum harbors a (SCS)Ni(II) pincer complex derived from nicotinic acid. Synthesis of the enzyme-bound cofactor requires LarB, LarC, and LarE, which are widely distributed in microorganisms. The functions of the accessory proteins are unknown, but the LarB C terminus resembles aminoimidazole ribonucleotide carboxylase/mutase, LarC binds Ni and could act in Ni delivery or storage, and LarE is a putative ATP-using enzyme of the pyrophosphatase-loop superfamily. Here, we show that LarB carboxylates the pyridinium ring of nicotinic acid adenine dinucleotide (NaAD) and cleaves the phosphoanhydride bond to release AMP. The resulting biscarboxylic acid intermediate is transformed into a bisthiocarboxylic acid species by two single-turnover reactions in which sacrificial desulfurization of LarE converts its conserved Cys176 into dehydroalanine. Our results identify a previously unidentified metabolic pathway from NaAD using unprecedented carboxylase and sulfur transferase reactions to form the organic component of the (SCS)Ni(II) pincer cofactor of LarA. In species where larA is absent, this pathway could be used to generate a pincer complex in other enzymes. PMID:27114550

  11. Considering Personality Type in Adult Learning: Using the Myers-Briggs Type Indicator in Instructor Preparation at PricewaterhouseCoopers

    ERIC Educational Resources Information Center

    Daisley, Richard J.

    2011-01-01

    This article explores the feasibility of using the Myers-Briggs Type Indicator (MBTI) as a framework for instructor development in a professional services training environment. It explores the consistency of MBTI with common adult learning theory, addresses questions on MBTI's reliability and validity, and explores the applicability of MBTI to the…

  12. Validity Evidence for the Myers-Briggs Type Indicator as a Measure of Hemisphere Dominance: Another View.

    ERIC Educational Resources Information Center

    Taggart, William M.; And Others

    1991-01-01

    Relationships among the scales of the Myers Briggs Type Indicator and the Human Information Processing Survey revealed in a study by S. C. Shiflett (1989) were reinvestigated in a study involving 554 college students (270 males and 284 females). One significant gender difference among the correlations was found. (SLD)

  13. The Myers-Briggs Type Indicator[R] and Mainstream Psychology: Analysis and Evaluation of an Unresolved Hostility

    ERIC Educational Resources Information Center

    Lloyd, John B.

    2012-01-01

    The Myers-Briggs Type Indicator (MBTI[R]) is widely used as a staff-development tool in the business and voluntary sectors. Its Psychological Type approach is found to be a valuable aid to understanding self and others and thus to enhancing effective team-working. This continuing and growing popularity is surprising in view of the disdain with…

  14. The Learning Styles of Registered Nurse Baccalaureate Students Based on the Myers-Briggs Type Indicator: Implications for Teaching.

    ERIC Educational Resources Information Center

    Wahl, Sharon C.

    This descriptive study proposed to use the Myers Briggs Type Indicator (MBTI) to identify the learning styles of registered nurses who have returned to school, and to recommend teaching strategies based on commonalities of their learning styles. The MBTI was administered to 240 registered nurses who were enrolled in either a leadership course in…

  15. Comparing University Students and Community College Students Learning Styles and Myers-Briggs Type Indicator (MBTI) Preferences.

    ERIC Educational Resources Information Center

    Herbster, Douglas L.; And Others

    This document reports on a study to determine if there is a pattern between specific learning styles and Myers-Briggs Type Indicator preferences. The learning style inventory used for the study, "The Teaching and Learning Styles Survey for Adolescents (TLC)," is based on Jungian style preferences--thinker, feeler, sensor, and intuitor--each of…

  16. A Review of the Myers-Briggs Type Inventory: A Potential Training Tool for Human Services Organizations.

    ERIC Educational Resources Information Center

    Aviles, Christopher B.

    The Myers-Briggs Type Inventory (MBTI) can be helpful in personal, career, and marriage counseling; conflict and stress management; team building; and understanding managerial and learning styles. It has great potential to be utilized in human services organizations for training purposes because it offers a way to conceptualize employee…

  17. The Devil Is in the Detail Regarding the Efficacy of Reading Recovery: A Rejoinder to Schwartz, Hobsbaum, Briggs, and Scull

    ERIC Educational Resources Information Center

    Reynolds, Meree; Wheldall, Kevin; Madelaine, Alison

    2009-01-01

    This rejoinder provides comment on issues raised by Schwartz, Hobsbaum, Briggs and Scull (2009) in their article about evidence-based practice and Reading Recovery (RR), written in response to Reynolds and Wheldall (2007). Particular attention is paid to the processes and findings of the What Works Clearinghouse evaluation of RR. The suggestion…

  18. The Myers-Briggs Type Indicator as a Tool to Facilitate Learning Outcomes for Team Building in the Classroom

    ERIC Educational Resources Information Center

    Berry, Priscilla; Wood, Cindy; Thornton, Barry

    2007-01-01

    Globalization and domestic competition are forcing businesses to rethink the human resources utilization process, and one method for considering again this challenge is creating a team culture. One key to this process for human resources development is the understanding of how to create the most successful teams. The use of the Myers-Briggs Type…

  19. "Presidential Address." Political Pawns in an Educational Endgame: Reflections on Bryant, Briggs, and Some Twentieth-Century School Questions

    ERIC Educational Resources Information Center

    Graves, Karen

    2013-01-01

    "Newsweek" ran an article on "The Homosexual Teacher" in December 1978. At the end of a tumultuous two-year period framed by Anita Bryant's anti-gay campaign in South Florida and John Briggs' proposition to bar gay and lesbian educators from working in California public schools, reporters concluded, "Most homosexual teachers are deeply plagued by…

  20. Muon Charge Sign Determination in LArIAT

    NASA Astrophysics Data System (ADS)

    Soubasis, Brandon; LArIAT Collaboration

    2016-03-01

    LArTPC In A Test beam experiment (LArIAT) at the Fermilab aims to calibrate and characterize liquid argon time projection chambers with a beam of charges particles. Liquid Argon Time Projection Chamber (LArTPC) are ideal neutrino detectors which has full 3D-imaging and particle Identification (PID) capability. Processes for which the μ undergoes capture vs. decay in LArIAT TPC for sign-determination (without magnetic field) is one area of studies we are currently interested in. Systematic study of the processes following μ- capture in argon have never been performed and LArTPC sign-determination capability has never been explored. Statistical analysis on topological criteria can be used to determine the sign of a particle's charge (without magnetic field). LArIAT test beam with selectable polarity will provide data for direct measurement of the sign separation efficiency (and purity) for muons.

  1. Bray-Liebhafsky and non-catalysed Briggs-Rauscher oscillating reactions

    NASA Astrophysics Data System (ADS)

    Schmitz, Guy; Furrow, Stanley D.

    2016-02-01

    In order to propose mechanisms of complicated chemical systems, it is necessary to study simpler subsystems. The mechanism we have proposed for the Bray-Liebhafsky (BL) oscillating reaction is based on kinetic studies of several reactions of iodine compounds between them and with hydrogen peroxide. Because the reactants of the non-catalysed Briggs-Rauscher (BR) oscillating reaction are the same as those of the BL reaction plus malonic acid, we propose now to extend the mechanism of the BL reaction to the BR reaction. With this aim, we add radical reactions of iodine compounds and of malonic acid. The choice of these reactions is based on our recent study of the unusual kinetics of the iodate reduction by high concentrations of hydrogen peroxide.

  2. Myers-Briggs psychological type and achievement in anatomy and physiology.

    PubMed

    Harasym, P H; Leong, E J; Juschka, B B; Lucier, G E; Lorscheider, F L

    1995-06-01

    Results from the Myers-Briggs Type Indicator (MBTI) for 259 nursing students were compared with their achievement on examinations in an undergraduate course in anatomy and physiology. Factor analysis demonstrated that no relationship existed between any of the eight individual personality traits purported to be measured by MBTI (i.e., E, Extrovert; I, Introvert; S, Sensing; N, Intuition; T, Thinking; F, Feeling; J, Judging; P, Perceiving) and examination scores in this course. The analysis also showed that the bipolar scales S vs. N and J vs. P collapsed into a single bipolar scale (S/J vs. N/P). This means that the MBTI is only capable of measuring three bipolar scales of personality traits instead of four scales as currently claimed. Contrary to other findings, results from an analysis of variance revealed no meaningful relationship between course achievement and psychological types. PMID:7598175

  3. Bimodal score distributions and the Myers-Briggs Type Indicator: fact or artifact?

    PubMed

    Bess, Tammy L; Harvey, Robert J

    2002-02-01

    We examined Myers-Briggs Type Indicator (MBTI) score distributions computed using item response theory (IRT) to assess the generalizability of earlier bimodality reports that have been cited in support of the "type" versus "trait" view of personality. Using the BILOG IRT program to score a sample of approximately 12,000 individuals who participated in leadership development programs, theta score distributions for the 4 dimensions of the MBTI computed using 10 (the BILOG default) versus 50 quadrature points were compared. Results indicated that past reports of bimodality were artifacts caused by BILOG's default use of a small number of quadrature points; when larger numbers of points were used, score distributions became strongly center-weighted. Although our findings are not supportive of the "type"-based hypothesis, the extremely high correlations between theta scores (rs > .996) suggest that no practical differences would be expected as a function of the number-of-quadrature-points decision. PMID:11936208

  4. Dark Sector Searches in LArTPC Experiments

    NASA Astrophysics Data System (ADS)

    Himwich, Elizabeth; MicroBooNE Collaboration

    2015-04-01

    Liquid Argon Time Projection Chamber (LArTPC) experiments, which allow for excellent event characterization and topological visualization, are sensitive to the distinct signatures of theorized low-energy dark sector phenomena. With the unique technology of LArTPC experiments, it is possible to perform a quasi-model independent dark sector search that can encompass a number of models. This talk will discuss the dark sector search in LArTPC experiments as well as the sensitivity of the MicroBooNE and Lar1-ND experiments to dark sector signatures predicted by leptophobic models, which has been evaluated based on simulated signal and background event rates.

  5. The association between Myers-Briggs Type Indicator and Psychiatry as the specialty choice

    PubMed Central

    Richard, George; Durkin, Martin

    2016-01-01

    Objectives The purpose of this pilot study is to examine the association between Myers-Briggs Type Indicator (MBTI) and prospective psychiatry residents. Methods Forty-six American medical schools were contacted and asked to participate in this study. Data were collected and an aggregated list was compiled that included the following information: date of MBTI administration, academic year, MBTI form/version, residency match information and student demographic information. The data includes 835 American medical students who completed the MBTI survey and matched into a residency training program in the United States. All analyses were performed using R 3.1.2. Results The probability of an introvert matching to a psychiatry residency is no different than that of an extravert (p= 0.30). The probability of an intuitive individual matching to a psychiatry residency is no different than that of a sensing type (p=0.20). The probability of a feeling type matching to a psychiatry residency is no different than that of a thinking type (p= 0.50). The probability of a perceiving type matching to a psychiatry residency is no different than that of a judging type (p= 0.60). Conclusions Further analyses may elicit more accurate information regarding the personality profile of prospective psychiatry residents. The improvement in communication, team dynamics, mentor-mentee relationships and reduction in workplace conflicts are possible with the awareness of MBTI personality profiles. PMID:26851600

  6. Pollen dispersal by catapult: Experiments of Lyman J. Briggs on the flower of mountain laurel

    USGS Publications Warehouse

    Nimmo, John R.; Hermann, Paula M.; Kirkham, M.B.; Landa, Edward R.

    2014-01-01

    The flower of Kalmia latifolia L. employs a catapult mechanism that flings its pollen to considerable distances. Physicist Lyman J. Briggs investigated this phenomenon in the 1950s after retiring as longtime director of the National Bureau of Standards, attempting to explain how hydromechanical effects inside the flower’s stamen could make it possible. Briggs’s unfinished manuscript implies that liquid under negative pressure generates stress, which, superimposed on the stress generated from the flower’s growth habit, results in force adequate to propel the pollen as observed. With new data and biophysical understanding to supplement Briggs’s experimental results and research notes, we show that his postulated negative-pressure mechanism did not play the exclusive and crucial role that he credited to it, though his revisited investigation sheds light on various related processes. Important issues concerning the development and reproductive function of Kalmia flowers remain unresolved, highlighting the need for further biophysical advances.

  7. Postcrystallization metasomatism in shergottites: Evidence from the paired meteorites LAR 06319 and LAR 12011

    NASA Astrophysics Data System (ADS)

    Howarth, Geoffrey H.; Liu, Yang; Chen, Yang; Pernet-Fisher, John F.; Taylor, Lawrence A.

    2016-03-01

    Apatite is the major volatile-bearing phase in Martian meteorites, containing structurally bound fluorine, chlorine, and hydroxyl ions. In apatite, F is more compatible than Cl, which in turn is more compatible than OH. During degassing, Cl strongly partitions into the exsolved phase, whereas F remains in the melt. For these reasons, the volatile concentrations within apatite are predictable during magmatic differentiation and degassing. Here, we present compositional data for apatite and merrillite in the paired enriched, olivine-phyric shergottites LAR 12011 and LAR 06319. In addition, we calculate the relative volatile fugacities of the parental melts at the time of apatite formation. The apatites are dominantly OH-rich (calculated by stoichiometry) with variable yet high Cl contents. Although several other studies have found evidence for degassing in the late-stage mineral assemblage of LAR 06319, the apatite evolutionary trends cannot be reconciled with this interpretation. The variable Cl contents and high OH contents measured in apatites are not consistent with fractionation either. Volatile fugacity calculations indicate that water and fluorine activities remain relatively constant, whereas there is a large variation in the chlorine activity. The Martian crust is Cl-rich indicating that changes in Cl contents in the apatites may be related to an external crustal source. We suggest that the high and variable Cl contents and high OH contents of the apatite are the results of postcrystallization interaction with Cl-rich, and possibly water-rich, crustal fluids circulating in the Martian crust.

  8. Enantioselective Regulation of Lactate Racemization by LarR in Lactobacillus plantarum

    PubMed Central

    Desguin, Benoît; Goffin, Philippe; Bakouche, Nordine; Diman, Aurélie; Viaene, Eric; Dandoy, Damien; Fontaine, Laetitia; Hallet, Bernard

    2014-01-01

    Lactobacillus plantarum is a lactic acid bacterium that produces a racemic mixture of l- and d-lactate from sugar fermentation. The interconversion of lactate isomers is performed by a lactate racemase (Lar) that is transcriptionally controlled by the l-/d-lactate ratio and maximally induced in the presence of l-lactate. We previously reported that the Lar activity depends on the expression of two divergently oriented operons: (i) the larABCDE operon encodes the nickel-dependent lactate racemase (LarA), its maturases (LarBCE), and a lactic acid channel (LarD), and (ii) the larR(MN)QO operon encodes a transcriptional regulator (LarR) and a four-component ABC-type nickel transporter [Lar(MN), in which the M and N components are fused, LarQ, and LarO]. LarR is a novel regulator of the Crp-Fnr family (PrfA group). Here, the role of LarR was further characterized in vivo and in vitro. We show that LarR is a positive regulator that is absolutely required for the expression of Lar activity. Using gel retardation experiments, we demonstrate that LarR binds to a 16-bp palindromic sequence (Lar box motif) that is present in the larR-larA intergenic region. Mutations in the Lar box strongly affect LarR binding and completely abolish transcription from the larA promoter (PlarA). Two half-Lar boxes located between the Lar box and the −35 box of PlarA promote LarR multimerization on DNA, and point mutations within one or both half-Lar boxes inhibit PlarA induction by l-lactate. Gel retardation and footprinting experiments indicate that l-lactate has a positive effect on the binding and multimerization of LarR, while d-lactate antagonizes the positive effect of l-lactate. A possible mechanism of LarR regulation by lactate enantiomers is proposed. PMID:25349156

  9. Atmospheric dispersion of an elevated release in a rural environment: Comparison between field SF 6 tracer measurements and computations of Briggs and ADMS models

    NASA Astrophysics Data System (ADS)

    Connan, O.; Leroy, C.; Derkx, F.; Maro, D.; Hébert, D.; Roupsard, P.; Rozet, M.

    2011-12-01

    The French Institute for Radiological Protection and Nuclear Safety (IRSN), in collaboration with VEOLIA (French environmental services company), conducted experimental campaigns to study atmospheric dispersion around an Energy Recycling Unit (EUR). The objectives were to study dispersion for an elevated release in a rural environment and to compare results with those of models. The atmospheric dispersion was studied by SF 6 tracer injection into a 40 m high stack. Maximum values of experimental Atmospheric Transfer Coefficients (ATC max) and horizontal dispersion standard deviations ( σh) were compared to predictions from a first generation Briggs gaussian model as well as results from the latest generation ADMS 4.1 gaussian model. In neutral atmospheric conditions, the Briggs and ADMS models are in good agreement with experimental data in terms of ATC and σh. In unstable condition, for σh, both ADMS and Briggs models slightly overestimate the data for winter and summer conditions. In unstable conditions, ADMS and Briggs models overestimated ATC max. The statistical evaluation of the models versus experimental data shows neither models ever meets all of the criteria for good performance. However, statistical evaluation indicates that the ADMS model is more suitable for neutral condition, and that the Briggs model is more reliable for summer unstable conditions.

  10. Histological characteristics and ultrastructure of polyethylene terephthalate LARS ligament after the reconstruction of anterior cruciate ligament in rabbits

    PubMed Central

    Yu, Shao-Bin; Yang, Rong-Hua; Zuo, Zhong-Nan; Dong, Qi-Rong

    2014-01-01

    Polyethylene terephthalate LARS ligament were the remnant of LARS ligament used for repairing posterior cruciate ligament obtained from operation. We want to study histological characteristics and ultrastructure of polyethylene terephthalate LARS ligament after the reconstruction of anterior cruciate ligament in rabbits. Therefore, we replaced the original ACL with polyethylene terephthalate LARS ligament which was covering with the remnant of ACL in 9 rabbits (L-LARS group), while just only polyethylene terephthalate LARS ligament were transplanted in 3 rabbits (LARS group) with the remnant of ACL. Compared with group LARS, inflammatory cell reaction and foreign body reaction were more significant in group L-LARS. Moreover, electron microscopy investigation showed the tissue near LARS fibers was highly cellular with a matrix of thin collagen fibrils (50-100 nm) in group L-LARS. These above findings suggest the polyethylene terephthalate LARS ligament possess the high biocompatibility, which contributes to the polyethylene terephthalate LARS covered with recipient connective tissues. PMID:25356104

  11. Scintillation light detection system in LArIAT

    NASA Astrophysics Data System (ADS)

    Kryczynski, P.

    2016-02-01

    The LArIAT experiment is currently taking data at Fermilab using a Liquid Argon TPC, with the aim of studying particle interactions and characterizing detector response for neutrino detectors using argon. In parallel, it serves as a test-bench to develop and evaluate the performance of the simulation, reconstruction, and analysis software used in LAr neutrino experiments. LArIAT also takes advantage of the scintillating capabilities of liquid argon and will evaluate the feasibility of using the light signal to determine calorimetric information and particle identification. To test this possibility, a scintillation light detection system consisting of high Quantum Efficiency (QE) PMT and Silicon Photomultiplier (SiPM) devices is installed in the cryostat, viewing the interior of the TPC. Light collection efficiency is maximized by means of lining the walls with reflector foils covered by a wavelength shifter layer. Collecting the light reflected at the boundaries of the active volume greatly improves also the uniformity of the light yield. Presented here are initial results of the LArIAT light detection system calibration together with the preliminary results of the dedicated simulation and its application in future LAr TPC experiments

  12. Cold Electronics Development for the LBNE LAr TPC

    NASA Astrophysics Data System (ADS)

    Thorn, C.; De Geronimo, Gianluigi; D'Andragora, Alessio; Li, Shaorui; Nambiar, Neena; Rescia, Sergio; Vernon, Emerson; Chen, Hucheng; Lanni, Francesco; Makowiecki, Don; Radeka, Veljko; Yu, Bo

    The LBNE Project is developing a design for multiple 20 kiloton liquid argon (LAr) time projection chambers to be used as the far detector for the Long Baseline Neutrino Experiment. An essential component of this design is a complete electronic readout system designed to operate in LAr (at 90K). This system is being implemented as a CMOS ASIC, in 180 nm commercial technology, that will provide low-noise readout of the signals induced on the TPC wires, digitization of those signals at 2 MS/s, zero-suppression, buffering and output multiplexing to a small number of cryostat feed-throughs. A resolution better than 1000 rms electrons at 200 pF input capacitance for an input range of 300 fC is required, along with low power (<15mW/channel) and operation in LAr with a lifetime greater than 15 years. An analog-only frontend has been successfully completed and fully evaluated, and will be used in the MicroBooNE LAr TPC. A prototype of the digital section has been fabricated and is being evaluated. The results demonstrate that CMOS transistors have lower noise and much improved dc characteristics at LAr temperature. We will describe the progress to date and plans for the remaining development.

  13. The Relationship between Personality Type and Software Usability Using the Myers-Briggs Type Indicator (MBTI) and the Software Usability Measurement Inventory (SUMI)

    ERIC Educational Resources Information Center

    Lindsey, William H.

    2011-01-01

    The study attempted to determine if there is a relationship between user's psychological personality types, measured by the Myers Briggs Type Indicator[R] (MBTI[R]) and distinct measures of usability measured by the Software Usability Measurement Inventory (SUMI). The study was expected to provide an answer to the following basic research…

  14. Teaching Teams To Be Teams: An Exercise Using the Myers-Briggs Type Indicator and the Five-Factor Personality Traits.

    ERIC Educational Resources Information Center

    Clinebell, Sharon; Stecher, Mary

    2003-01-01

    Management students formed teams after completing exercises based on the Myers-Briggs Type Indicator and the Five-Factor Model of Personality. Team members examined how types and traits might affect performance. Most students indicated that understanding personality increased awareness of behavior. Teams that used extreme division of labor were…

  15. Some Fruits of Genius: Lars Onsager and the Ising Model

    NASA Astrophysics Data System (ADS)

    Fisher, Michael E.

    2006-03-01

    The story of the exact solution of the two-dimensional Ising model by Lars Onsager in the 1940's will be sketched and some of the striking developments following from it, especially for the behavior of fluctuating interfaces, will be recounted.

  16. Operation plan for the data 100/LARS terminal system

    NASA Technical Reports Server (NTRS)

    Bowen, A. J., Jr.

    1980-01-01

    The Data 100/LARS terminal system provides an interface for processing on the IBM 3031 computer system at Purdue University's Laboratory for Applications of Remote Sensing. The environment in which the system is operated and supported is discussed. The general support responsibilities, procedural mechanisms, and training established for the benefit of the system users are defined.

  17. ICARUS: An Innovative Large LAR Detector for Neutrino Physics

    SciTech Connect

    Vignoli, C.; Barni, D.; Disdier, J. M.; Rampoldi, D.; Passardi, G.

    2006-04-27

    ICARUS is an international project that foresees the installation of very large LAr detectors inside the Gran Sasso underground laboratory in order to be sensitive to rare phenomena of particle physics. The detection technique is based on the collection of electrons produced by particle interactions in LAr by a matrix of thousands of thin wires. At the moment the project foresees the installation of a 600,000-kg vessel (T600). The total amount of LAr can be expanded in a modular way to masses of the order of 106 kg. The T600 houses two identical 300,000-kg Ar sub-cryostats that are aluminum boxes about 20-m long, 4-m high and 4-m wide. Safety requirements for the underground installation have led to a unique design for the vessels to prevent LAr spillages even in the case of inner cryostat failure. Electrons must drift over meters requiring the development of special gas and liquid Ar purification units to provide an extremely high LAr purity (better then 0.1 ppb). The cooling system has been designed to assure a high thermal uniformity in the detector volume (less than 1-K differential). The cryogenic system associated with the final ICARUS configuration is based on three N2 refrigerators, three 30-m3 tanks and pump driven two-phase N2 forced-flow cooling of the various sub-systems. The T600 was successfully tested in Pavia in 2001 and it is now under installation in Gran Sasso for final operation. The future mass expansion strategy is under investigation.

  18. Obituary: Gary Lars Grasdalen, 1945-2003

    NASA Astrophysics Data System (ADS)

    Strom, Stephen Eric

    2003-12-01

    With the passing of Gary Grasdalen on 20 April 2003 the astronomical community has lost one its most creative members. Born in Albert Lea, Minnesota on 7 October 1945 to the farming family of Lars G. and Lillie Grasdalen, Gary developed a strong childhood interest in science, and a particular fascination with astronomy. In 1964, he entered Harvard College intending to pursue those interests. During his freshman year, Gary enrolled in an undergraduate research seminar in which he first displayed the combination of keen insight and imagination in applying new techniques that was manifest throughout his professional career. In 1968, he published his first two papers---studies of the C12/C13 ratio in metal deficient stars, and of Fe I and Fe II transition probabilities---which summarized research carried out during his junior and senior years at Harvard. Grasdalen next entered the astronomy graduate program at the University of California, Berkeley. There he developed a strong interest in the early stages of stellar evolution and, in particular, the potential of S-1 image intensifiers and newly available near-infrared detectors to detect and analyze the stellar populations embedded within their parent molecular cloud complexes. Following award of his PhD in 1972, Grasdalen was appointed to the staff at the Kitt Peak National Observatory. Early in his career at KPNO, Gary developed tools that enabled routine near-infrared mapping of nearby molecular cloud complexes, most notably the telescope control programs that enabled precise raster scanning of these regions. Those same programs were some of the many innovations in which Gary had a hand. These innovations enabled a generation of KPNO observers in the 1970s to fully exploit the power of the newly commissioned Mayall telescope as well as the smaller telescopes on Kitt Peak. In 1973, he published the first map of the central region of a molecular cloud, which revealed an extensive embedded, optically obscured

  19. The Role of the Myers-Briggs Personality Type and Emotional Intelligence in Marital Satisfaction among Married Female Students at Tehran University.

    PubMed

    Shirzad, Galin

    2016-01-01

    The present descriptive correlational study was conducted to predict the role of emotional intelligence and the Myers-Briggs personality type in marital satisfaction in married female students Tehran University in 2015. The study population consisted of all the married female students at Tehran University who visited Iran MBTI center between 22.04.2015 and 21.06.2015. A total of 140 students were selected as the study samples. Data were collected using the Myer-Briggs Type Indicator, the Bar-On Emotional Intelligence Questionnaire and the Enrich Marital Satisfaction Scale and were then analyzed in SPSS-20 using the multivariate regression analysis. The results obtained showed that emotional intelligence (interpersonal and intra-personal skills) and personality type (extraverted and structured) can predict marital satisfaction. PMID:27302443

  20. Thirumŭlar--pioneer of the immunology concept.

    PubMed

    Rajasekaran, R; Narayana, Ala

    2006-01-01

    Extraordinary longevity of life, made possible by repeated reading and following of the text Thirumandiram 3000 - written by great Siddhar Thirumŭlar. He the Prince of Mystics is one of the 18 luminous Siddhars and the first and foremost #1 Siva śiddhăndi. Historians and scholars predicted his life period between 5th to 8th centuries AD. In his teachings, he explained the kinds of 'Thavam' (Yoga) and he insisted the #2 'Kăya siddhi'. Thousands of years ago, he wrote in detail about Anatomy of microcosm, Siddha physiology, Humoural pathology, Science of pulse, Microcosmic Atom theory, Immunology concept and Immortalization of our body. His marvelous text Thirumandiram deals with Medical science, Life science, Natural science and Divine. In this article authors, discuss about the biography of Thirumŭlar and his medical works. PMID:18175648

  1. Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury

    PubMed Central

    Xu, Bin; Park, Dongsun; Ohtake, Yosuke; Li, Hui; Hayat, Umar; Li, Junjun; Selzer, Michael E.; Longo, Frank M.; Li, Shuxin

    2014-01-01

    Extracellular matrix molecule chondroitin sulfate proteoglycans (CSPGs) are highly upregulated in scar tissues and form a potent chemical barrier for CNS axon regeneration. Recent studies support that the receptor protein tyrosine phosphatase σ (PTPσ) and its subfamily member leukocyte common antigen related phosphatase (LAR) act as transmembrane receptors to mediate CSPG inhibition. PTPσ deficiency increased regrowth of ascending axons into scar tissues and descending corticospinal tract (CST) axons into the caudal spinal cord after spinal cord injury (SCI). Pharmacological LAR inhibition enhanced serotonergic axon growth in SCI mice. However, transgenic LAR deletion on axon growth in vivo and role of LAR in regulating regrowth of other fiber tracts have not been studied. Here, we studied role of LAR in restricting regrowth of injured descending CNS axons in deficient mice. LAR deletion increased regrowth of serotonergic axons into scar tissues and caudal spinal cord after dorsal overhemitransection. LAR deletion also stimulated regrowth of CST fibers into the caudal spinal cord. LAR protein was upregulated days to weeks after injury and co-localized to serotonergic and CST axons. Moreover, LAR deletion improved functional recovery by increasing BMS locomotor scores and stride length and reducing grid walk errors. This is the first transgenic study that demonstrates crucial role of LAR in restricting regrowth of injured CNS axons. PMID:25220840

  2. Reinterpreting the Myers-Briggs Type Indicator from the perspective of the five-factor model of personality.

    PubMed

    McCrae, R R; Costa, P T

    1989-03-01

    The Myers-Briggs Type Indicator (MBTI; Myers & McCaulley, 1985) was evaluated from the perspectives of Jung's theory of psychological types and the five-factor model of personality as measured by self-reports and peer ratings on the NEO Personality Inventory (NEO-PI; Costa & McCrae, 1985b). Data were provided by 267 men and 201 women ages 19 to 93. Consistent with earlier research and evaluations, there was no support for the view that the MBTI measures truly dichotomous preferences or qualitatively distinct types; instead, the instrument measures four relatively independent dimensions. The interpretation of the Judging-Perceiving index was also called into question. The data suggest that Jung's theory is either incorrect or inadequately operationalized by the MBTI and cannot provide a sound basis for interpreting it. However, correlational analyses showed that the four MBTI indices did measure aspects of four of the five major dimensions of normal personality. The five-factor model provides an alternative basis for interpreting MBTI findings within a broader, more commonly shared conceptual framework. PMID:2709300

  3. Liprin-alpha has LAR-independent functions in R7 photoreceptor axon targeting.

    PubMed

    Hofmeyer, Kerstin; Maurel-Zaffran, Corinne; Sink, Helen; Treisman, Jessica E

    2006-08-01

    In the Drosophila visual system, the color-sensing photoreceptors R7 and R8 project their axons to two distinct layers in the medulla. Loss of the receptor tyrosine phosphatase LAR from R7 photoreceptors causes their axons to terminate prematurely in the R8 layer. Here we identify a null mutation in the Liprin-alpha gene based on a similar R7 projection defect. Liprin-alpha physically interacts with the inactive D2 phosphatase domain of LAR, and this domain is also essential for R7 targeting. However, another LAR-dependent function, egg elongation, requires neither Liprin-alpha nor the LAR D2 domain. Although human and Caenorhabditis elegans Liprin-alpha proteins have been reported to control the localization of LAR, we find that LAR localizes to focal adhesions in Drosophila S2R+ cells and to photoreceptor growth cones in vivo independently of Liprin-alpha. In addition, Liprin-alpha overexpression or loss of function can affect R7 targeting in the complete absence of LAR. We conclude that Liprin-alpha does not simply act by regulating LAR localization but also has LAR-independent functions. PMID:16864797

  4. A Direct Comparison of HI and Lyα Morphologies in Two LARS Galaxies

    NASA Astrophysics Data System (ADS)

    Fitzgibbon, Kathleen; Cannon, John M.; Freeland, Emily; Hayes, Matthew; Östlin, Göran; LARS Team

    2016-01-01

    The Lyman-Alpha Reference Sample (LARS) and its extension (eLARS) represent an exhaustive campaign to reverse-engineer galaxies. The main goal is to understand how Lyα is transported within galaxies: what fraction of it escapes, and what physical properties affect Lyα morphology and radiative transport (e.g. dust and gas content, metallicity, kinematics, properties of the stellar population). Neutral hydrogen emission, which can be used to determine a galaxy's structure and kinematics, was observed using the B and C configurations of the Very Large Array in two galaxies from the sample: LARS02 and LARS09. Images of the HI mass surface density and of the intensity weighted HI velocity field were created at angular scales of ~8 arcseconds. Extended HI gas is detected at high significance up to ˜30 kpc from the optical body of LARS02. LARS09 has a severely disturbed optical morphology; our new HI observations reveal that LARS09 is interacting with the nearby field galaxy SDSS J082353.65+280622.2. In combination with direct imaging of the Lyα morphology from the Hubble Space Telescope, this program has produced the first direct comparison of Lyα and HI morphologies. These observations demonstrate concept for a significant observational campaign that will produce similar comparisons in the remaining 40 LARS+eLARS galaxies.KF was partially supported by a Science Education Award from the Howard Hughes Medical Institute (HHMI) to Macalester College.

  5. Site amplification at Avcılar, Istanbul

    NASA Astrophysics Data System (ADS)

    Ergin, M.; Özalaybey, S.; Aktar, M.; Yalçin, M. N.

    2004-10-01

    Avcılar is the suburb of Istanbul that was most heavily damaged during the August 17, 1999 Mw 7.4 Izmit earthquake. Strong ground motion caused fatalities and damage in Avcılar despite being ˜90 km from the epicenter. We deployed five portable seismograph stations equipped with Reftek 24-bit recorders and L4C-3D seismometers for 2 months, in order to understand why the local site response was different from elsewhere in Istanbul. A reference station was placed on a hard rock site, and the remaining four stations were placed on other geological units, in areas that had experienced varying levels of damage. We calculated frequency-dependent ground amplification curves by taking the ratios of the spectra at soft and hard rock sites. We obtained similar site response curves for most earthquakes at each site in the frequency range of 0.3-1.6 Hz, and observed no significant site amplification beyond 2.0 Hz at any site. The overall characteristics of the recorded S-waveforms and our modeling of the calculated site amplification curves are consistent with amplification as a result of trapping of seismic energy within a 100-150 m thick, low-velocity subsurface layer. We also review the applicability of microtremor measurements to estimate local site effects at Avcılar. For these data, we used ratios of spectra of horizontal to vertical components to obtain each site response. These results are compared with standard spectral ratios. These microtremor measurements provide consistent estimates of the amplification at most sites at the higher end of the frequency band, namely above 1 Hz. The results from both methods indeed agree well in this part of the frequency band. However, the microtremor method fails to detect amplification at lower frequencies, namely <1.0 Hz.

  6. eLARS - extending the Lyman Alpha Reference Sample

    NASA Astrophysics Data System (ADS)

    Oestlin, Goeran

    2013-10-01

    Despite its pivotal importance in high-z astrophysics, Lyman alpha {LyA} imaging is a relatively unexplored territory, due to its reliance on HST for far UV imaging. Our team has pioneered systematic LyA imaging in the local universe and developed techniques for producing photometrically accurate images using HST. We recently finished LARS, the first systematic LyA imaging study of 14 UV+H-alpha selected starbursts in the local universe. We found further evidence for LyA variation on physical scales from 30 pc to several kpc, often in a manner uncorrelated with the UV continuum, H-alpha or the galaxy in general. Specifically, we find that when LyA is bright and when a lot of LyA manages to escape, it is always found in the form of a large scale halo. This is, in all such cases, more extended than the UV or H-alpha emission, but rarely symmetric.While these results are fascinating, LARS consists of extreme starbursts that contribute only a small fraction of the total UV and star-formation density at low and intermediate {z 2} redshifts. Given the importance of the LyA line for finding galaxies and for galaxy evolution studies it is imperative to now generalize the investigation and produce a fully representative quantitative framework. We here propose to image a sample of 28 local galaxies, dominated by more disk like objects {c.f. the irregular objects of LARS}, and the kind of objects than dominate the local FUV luminosity function. Specifically, we will investigate the effects of geometry and galaxy orientation of the emergent LyA emission.

  7. MicroBooNE, A Liquid Argon Time Projection Chamber (LArTPC) Neutrino Experiment

    SciTech Connect

    Katori, Teppei

    2011-07-01

    Liquid Argon time projection chamber (LArTPC) is a promising detector technology for future neutrino experiments. MicroBooNE is a upcoming LArTPC neutrino experiment which will be located on-axis of Booster Neutrino Beam (BNB) at Fermilab, USA. The R&D efforts on this detection method and related neutrino interaction measurements are discussed.

  8. Language Arts Routing System (LARS) Instructor's Manual. Community College English Project.

    ERIC Educational Resources Information Center

    Michael, Gary; Sliger, Mary

    Implemented on the PLATO IV computer-assisted instruction facility located at the University of Illinois at Urbana-Champaign, the Language Arts Routing System (LARS) is a package of lessons and tests designed to provide remedial training in certain basic language arts skills. LARS is a system which may be used by itself or as an adjunct to regular…

  9. University studies science course selection and academic achievement in relation to the Myers-Briggs Type Indicator

    NASA Astrophysics Data System (ADS)

    Skauge, Suzanne Elizabeth

    This research conducted at a southern regional university studied general education (University Studies - US) science course selection and academic success in US science in relation to Myers-Briggs Type Indicator (MBTI) preference categories (SF, ST, NF and NT). Additionally, differences in type preferences among students with mathematics and/or reading competency were explored. Data was examined for 755 students enrolled in the freshman success seminar course between Fall 1989 and Spring 1995 who had completed the MBTI test as part of that class. US science courses examined were grouped by science study: earth science, biology, chemistry and physics. Academic success was defined as a grade of "C" or higher and proficiency criteria were dictated by the university catalog. The study's nonparametric test results did not find any significant differences between MBTI type preferences and the two main areas of focus, US science course selection and academic success in US science courses. However, significant proportional differences were found between type preferences in relation to student reading competency (sig. = .03), as well as, reading competency and academic success in science (sig. = .04) even though fairly weak relationships existed between the variables with contingency coefficients of .11 and .10 respectively. All other relationships tested proved not significant. Each type's course selection closely reflected the overall sample: Earth Science 52.3%, Biology 34%, Chemistry 7.5% and Physics 6.1%. Nearly one-fifth (19.7%) of the sample were not successful in their selected science course. Less than two-fifths (37.7%) of student sample were not mathematics and/or reading competent. Academically in science intuitive types tended to do better than sensing types and feeling types tended to better than thinking types (NF 2.41, NT 2.36, SF 2.29 and ST 2.23). Further analysis found the TF preference scale contributed more toward the significant differences in reading

  10. ATLAS LAr calorimeter performance and LHC Run-2 commissioning

    NASA Astrophysics Data System (ADS)

    Spettel, Fabian

    2016-07-01

    The ATLAS detector was built to study proton-proton collisions produced by the Large Hadron Collider (LHC) at a center of mass energy of up to 14 TeV. The Liquid Argon (LAr) calorimeters are used for all electromagnetic calorimetry as well as the hadronic calorimetry in the endcap and forward regions. They have shown excellent performance during the first LHC data taking campaign, from 2010 to 2012, so-called Run 1, at a peak luminosity of 8 ×1033cm-2s-1. During the next run, peak luminosities of 1.5 ×1034cm-2s-1 and even higher are expected at a 25 ns bunch spacing. Such a high collision rate may have an impact on the quality of the energy reconstruction which is attempted to be maintained at a high level using a calibration procedure described in this contribution. It also poses major challenges to the first level of the trigger system which is constrained to a maximal rate of 100 kHz. For Run-3, scheduled to start in 2019, instantaneous luminosity as high as 3 ×1034cm-2s-1 are foreseen imposing an upgrade of the LAr trigger system to maintain its performance. A demonstrator containing prototypes of the upgraded trigger electronic architecture has been installed on one of the barrel electromagnetic calorimeter readout front end crates to test it during the Run-2 campaign. The new architecture and its benefits for data taking will be discussed below as well as the results from first beam splash events.

  11. Cryopreservation of lar gibbon semen collected by manual stimulation.

    PubMed

    Takasu, Masaki; Morita, Natsumi; Tajima, Shunichiro; Almunia, Julio; Maeda, Masami; Kamiguchi, Takashi

    2016-07-01

    We confirmed ejaculation as a result of manual stimulation in a lar gibbon, and attempted to cryopreserve the semen using TES-Tris-egg yolk-based (TTE) extender. After measuring the amount of semen (g), we first diluted the semen with TTE extender, and calculated sperm concentration (sperm/ml), total sperm count (sperm), and progressive sperm motility (%). Then, we cooled diluted semen slowly to 4 °C over 2 h, and added an equal volume of secondary extender containing glycerol over 30 min. Finally, we flash-froze the semen solution by plunging into liquid nitrogen. In addition, we freeze-thawed the solution to determine the recovery rate of the motile sperm. Collection of semen was successful on four of the five occasions. The median (min-max) quantity of ejaculate was 0.19 g (0.09-0.26 g), the median sperm concentration was 1.38 × 10(9) sperm/ml (1.20-1.53 × 10(9) sperm/ml), and the median total sperm count was 0.26 × 10(9) sperm (0.11-0.40 × 10(9) sperm). Moreover, the median sperm motility immediately after ejaculation was 65 % (60-75 %), the median sperm motility after freeze-thawing was 30 % (25-35 %), and the median recovery rate was 42.3 % (40.0-58.3 %). We were able to (1) collect semen from a lar gibbon by manual stimulation, (2) reveal andrological findings regarding semen characteristics, and (3) preserve the genetic resource using TTE cryopreservation. PMID:27179974

  12. Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance.

    PubMed

    Warhurst, David C; Craig, John C; Raheem, K Saki

    2016-01-01

    Antimalarial chloroquine (CQ) prevents haematin detoxication when CQ-base concentrates in the acidic digestive vacuole through protonation of its p-aminopyridine (pAP) basic aromatic nitrogen and sidechain diethyl-N. CQ export through the variant vacuolar membrane export channel, PFCRT, causes CQ-resistance in Plasmodium falciparum but 3-methyl CQ (sontochin SC), des-ethyl amodiaquine (DAQ) and bis 4-aminoquinoline piperaquine (PQ) are still active. This is determined by changes in drug accumulation ratios in parasite lipid (LAR) and in vacuolar water (VAR). Higher LAR may facilitate drug binding to and blocking PFCRT and also aid haematin in lipid to bind drug. LAR for CQ is only 8.3; VAR is 143,482. More hydrophobic SC has LAR 143; VAR remains 68,523. Similarly DAQ with a phenol substituent has LAR of 40.8, with VAR 89,366. In PQ, basicity of each pAP is reduced by distal piperazine N, allowing very high LAR of 973,492, retaining VAR of 104,378. In another bis quinoline, dichlorquinazine (DCQ), also active but clinically unsatisfactory, each pAP retains basicity, being insulated by a 2-carbon chain from a proximal nitrogen of the single linking piperazine. While LAR of 15,488 is still high, the lowest estimate of VAR approaches 4.9 million. DCQ may be expected to be very highly lysosomotropic and therefore potentially hepatotoxic. In 11 pAP antimalarials a quadratic relationship between logLAR and logResistance Index (RI) was confirmed, while log (LAR/VAR) vs logRI for 12 was linear. Both might be used to predict the utility of structural modifications. PMID:27483471

  13. Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance

    PubMed Central

    Warhurst, David C.; Craig, John C.

    2016-01-01

    Antimalarial chloroquine (CQ) prevents haematin detoxication when CQ-base concentrates in the acidic digestive vacuole through protonation of its p-aminopyridine (pAP) basic aromatic nitrogen and sidechain diethyl-N. CQ export through the variant vacuolar membrane export channel, PFCRT, causes CQ-resistance in Plasmodium falciparum but 3-methyl CQ (sontochin SC), des-ethyl amodiaquine (DAQ) and bis 4-aminoquinoline piperaquine (PQ) are still active. This is determined by changes in drug accumulation ratios in parasite lipid (LAR) and in vacuolar water (VAR). Higher LAR may facilitate drug binding to and blocking PFCRT and also aid haematin in lipid to bind drug. LAR for CQ is only 8.3; VAR is 143,482. More hydrophobic SC has LAR 143; VAR remains 68,523. Similarly DAQ with a phenol substituent has LAR of 40.8, with VAR 89,366. In PQ, basicity of each pAP is reduced by distal piperazine N, allowing very high LAR of 973,492, retaining VAR of 104,378. In another bis quinoline, dichlorquinazine (DCQ), also active but clinically unsatisfactory, each pAP retains basicity, being insulated by a 2-carbon chain from a proximal nitrogen of the single linking piperazine. While LAR of 15,488 is still high, the lowest estimate of VAR approaches 4.9 million. DCQ may be expected to be very highly lysosomotropic and therefore potentially hepatotoxic. In 11 pAP antimalarials a quadratic relationship between logLAR and logResistance Index (RI) was confirmed, while log (LAR/VAR) vs logRI for 12 was linear. Both might be used to predict the utility of structural modifications. PMID:27483471

  14. LARS Artificial Ligament Versus ABC Purely Polyester Ligament for Anterior Cruciate Ligament Reconstruction

    PubMed Central

    Iliadis, Dimitrios Ph.; Bourlos, Dimitrios N.; Mastrokalos, Dimitrios S.; Chronopoulos, Efstathios; Babis, George C.

    2016-01-01

    Background: Graft choice for anterior cruciate ligament (ACL) reconstruction is of critical importance. Various grafts have been used so far, with autografts long considered the optimal solution for the treatment of ACL-deficient knees. Limited data are available on the long-term survivorship of synthetic grafts. Purpose: To compare the functional outcome and survivorship of ACL reconstructions performed using the LARS (ligament augmentation and reconstruction system) ligament and the ABC (active biosynthetic composite) purely polyester ligament. Study Design: Case series; Level of evidence, 4. Methods: The results of 72 patients who underwent primary arthroscopic ACL reconstruction with the LARS ligament and 31 cases with an ABC purely polyester ligament were reviewed. The mean follow-up periods for the LARS and ABC groups were 9.5 and 5.1 years, respectively. A survivorship analysis of the 2 synthetic grafts was performed using the Kaplan-Meier method with a log-rank test (Mantel-Cox, 95% CI). Lysholm, Tegner activity, Knee injury and Osteoarthritis Outcome Score (KOOS), and International Knee Documentation Committee (IKDC) scores as well as laxity measurements obtained using a KT-1000 arthrometer were recorded for all intact grafts, and a Mann-Whitney U test was used for comparison reasons. Results: The rupture rates for LARS and ABC grafts were 31% (95% CI, 20%-42%) and 42% (95% CI, 25%-59%), respectively. For intact grafts, the mean Lysholm score was good for both groups (90 for the LARS group and 89 for the ABC group), with the majority of patients returning to their preinjury level of activities, and the mean IKDC score was 90 for the LARS group and 86 for the ABC group. Conclusion: The rupture rates of both LARS and ABC grafts were both high. However, the LARS ligament provided significantly better survivorship compared with the ABC ligament at short- to midterm follow-up (95% CI). PMID:27453894

  15. SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development.

    PubMed

    Choi, Yeonsoo; Nam, Jungyong; Whitcomb, Daniel J; Song, Yoo Sung; Kim, Doyoun; Jeon, Sangmin; Um, Ji Won; Lee, Seong-Gyu; Woo, Jooyeon; Kwon, Seok-Kyu; Li, Yan; Mah, Won; Kim, Ho Min; Ko, Jaewon; Cho, Kwangwook; Kim, Eunjoon

    2016-01-01

    Synaptogenic adhesion molecules play critical roles in synapse formation. SALM5/Lrfn5, a SALM/Lrfn family adhesion molecule implicated in autism spectrum disorders (ASDs) and schizophrenia, induces presynaptic differentiation in contacting axons, but its presynaptic ligand remains unknown. We found that SALM5 interacts with the Ig domains of LAR family receptor protein tyrosine phosphatases (LAR-RPTPs; LAR, PTPδ, and PTPσ). These interactions are strongly inhibited by the splice insert B in the Ig domain region of LAR-RPTPs, and mediate SALM5-dependent presynaptic differentiation in contacting axons. In addition, SALM5 regulates AMPA receptor-mediated synaptic transmission through mechanisms involving the interaction of postsynaptic SALM5 with presynaptic LAR-RPTPs. These results suggest that postsynaptic SALM5 promotes synapse development by trans-synaptically interacting with presynaptic LAR-RPTPs and is important for the regulation of excitatory synaptic strength. PMID:27225731

  16. SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development

    PubMed Central

    Choi, Yeonsoo; Nam, Jungyong; Whitcomb, Daniel J.; Song, Yoo Sung; Kim, Doyoun; Jeon, Sangmin; Um, Ji Won; Lee, Seong-Gyu; Woo, Jooyeon; Kwon, Seok-Kyu; Li, Yan; Mah, Won; Kim, Ho Min; Ko, Jaewon; Cho, Kwangwook; Kim, Eunjoon

    2016-01-01

    Synaptogenic adhesion molecules play critical roles in synapse formation. SALM5/Lrfn5, a SALM/Lrfn family adhesion molecule implicated in autism spectrum disorders (ASDs) and schizophrenia, induces presynaptic differentiation in contacting axons, but its presynaptic ligand remains unknown. We found that SALM5 interacts with the Ig domains of LAR family receptor protein tyrosine phosphatases (LAR-RPTPs; LAR, PTPδ, and PTPσ). These interactions are strongly inhibited by the splice insert B in the Ig domain region of LAR-RPTPs, and mediate SALM5-dependent presynaptic differentiation in contacting axons. In addition, SALM5 regulates AMPA receptor-mediated synaptic transmission through mechanisms involving the interaction of postsynaptic SALM5 with presynaptic LAR-RPTPs. These results suggest that postsynaptic SALM5 promotes synapse development by trans-synaptically interacting with presynaptic LAR-RPTPs and is important for the regulation of excitatory synaptic strength. PMID:27225731

  17. Peology and Geochemistry of New Paired Martian Meteorites 12095 and LAR 12240

    NASA Technical Reports Server (NTRS)

    Funk, R. C.; Brandon, A. D.; Peslier, A.

    2015-01-01

    The meteorites LAR 12095 and LAR 12240 are believed to be paired Martian meteorites and were discovered during the Antarctic Search for Meteorites (ANSMET) 2012-2013 Season at Larkman Nunatak. The purpose of this study is to characterize these olivine-phyric shergottites by analyzing all mineral phases for major, minor and trace elements and examining their textural relationships. The goal is to constrain their crystallization history and place these shergottites among other Martian meteorites in order to better understand Martian geological history.

  18. Regulation of Platelet Derived Growth Factor Signaling by Leukocyte Common Antigen-related (LAR) Protein Tyrosine Phosphatase: A Quantitative Phosphoproteomics Study.

    PubMed

    Sarhan, Adil R; Patel, Trushar R; Creese, Andrew J; Tomlinson, Michael G; Hellberg, Carina; Heath, John K; Hotchin, Neil A; Cunningham, Debbie L

    2016-06-01

    Intracellular signaling pathways are reliant on protein phosphorylation events that are controlled by a balance of kinase and phosphatase activity. Although kinases have been extensively studied, the role of phosphatases in controlling specific cell signaling pathways has been less so. Leukocyte common antigen-related protein (LAR) is a member of the LAR subfamily of receptor-like protein tyrosine phosphatases (RPTPs). LAR is known to regulate the activity of a number of receptor tyrosine kinases, including platelet-derived growth factor receptor (PDGFR). To gain insight into the signaling pathways regulated by LAR, including those that are PDGF-dependent, we have carried out the first systematic analysis of LAR-regulated signal transduction using SILAC-based quantitative proteomic and phosphoproteomic techniques. We haveanalyzed differential phosphorylation between wild-type mouse embryo fibroblasts (MEFs) and MEFs in which the LAR cytoplasmic phosphatase domains had been deleted (LARΔP), and found a significant change in abundance of phosphorylation on 270 phosphosites from 205 proteins because of the absence of the phosphatase domains of LAR. Further investigation of specific LAR-dependent phosphorylation sites and enriched biological processes reveal that LAR phosphatase activity impacts on a variety of cellular processes, most notably regulation of the actin cytoskeleton. Analysis of putative upstream kinases that may play an intermediary role between LAR and the identified LAR-dependent phosphorylation events has revealed a role for LAR in regulating mTOR and JNK signaling. PMID:27074791

  19. Evaluation of the antioxidant capacity of natural polyphenolic compounds using a macrocyclic Ni-(II) complex-catalysed Briggs-Rauscher reaction.

    PubMed

    Li, Mengshuo; Hu, Gang; Chen, Yangyang

    2016-04-15

    This paper reports a method for evaluating antioxidant capacity based on the inhibitory effects of a macrocyclic Ni(II) complex-catalysed Briggs-Rauscher reaction. The macrocyclic Ni(II) complex NiL(ClO4)2, in which L is 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene, is a porphyrin-like compound, the structure of which can be found in certain enzymes. The experiments indicated that three natural compounds could temporarily quench the oscillations for a period of time prior to regeneration of oscillations. The inhibition time was related to the compound type and concentration; thus, procedures for evaluating the antioxidant activities of polyphenolic compounds were successfully established. Three polyphenolic compounds were tested to evaluate their antioxidant activities: protocatechuic acid, rutin hydrate and procyanidin. Of these three naturally occurring compounds, procyanidin was found to be the most efficient antioxidant. We have also discussed the reaction of the antioxidant with the hydroperoxyl radical (HOO) present in the oscillating system. PMID:26617044

  20. LAr calorimeter for SCC with a common vacuum bulkhead---a concept to improve hermeticity

    SciTech Connect

    Pope, W.L. ); Watt, R.D. )

    1989-11-01

    A new concept for a Barrel/Endcap LAr Calorimeter (LAC) is described in which the Barrel and Endcaps are in separate vacuum enclosures but share a common vacuum bulkhead (CVB). We explore 2 possible bulkhead construction types; welded plate sandwich panels, and brazed sandwich panels in which the core is an isotropic cellular solid--foamed aluminum. Gas lines and electric cables from he innermost Drift Chamber pass through radial holes in the core of the sandwich bulkhead. The CVB concept offers the potential to obtain a more hermetic calorimeter with significantly reduced dead material and/or space in the interface region common to conventional design LAr detectors for the SSC with Endcap features. To utilize a common additional steps to remove the Drift Chamber, a large increase in Endcap standby heat leak, and perhaps, new cryogenic safety issues. We find that significant amount of dead mass can be removed from critical regions of the vacuum shells when compared to a promising SSC LAC reference design. It is also shown that the increased standby heat leak of this concept can be easily removed by existing cooling capacity in another large LAr calorimeter. It is further shown that shut-downs need not be appreciably longer. Finally, it is argued that cryogen spill hazards can be avoided if the Endcap's LAr is removed during Drift chamber maintenance shutdowns, and that cryogenic safety is not compromised.

  1. SER-LARS, Volume 4. Learning Objective History III. 1975-76 Edition.

    ERIC Educational Resources Information Center

    Montgomery County Intermediate Unit 23, Blue Bell, PA.

    The fourth volume in the SER-LARS (Special Education Resources Location Analysis and Retrieval System) series, a diagnostic-prescriptive instructional data bank for teachers of handicapped children, presents a continuation of learning objectives organized by content descriptions. Entrees give a history of the use of each objective along with…

  2. SER-LARS, Volume 6. Instructional Materials, Teacher Made and Commercially Adapted. 1975-76 Edition.

    ERIC Educational Resources Information Center

    Montgomery County Intermediate Unit 23, Blue Bell, PA.

    The sixth of nine volumes in the Special Education Resources Location Analysis and Retrieval System (SER-LARS), a diagnostic-prescriptive instructional data bank for teachers of handicapped children, presents an inventory of teacher-made and commercially adapted instructional materials. The instructional materials are organized by accession number…

  3. SER-LARS, Volume 3. Learning Objective History II. 1975-76 Edition.

    ERIC Educational Resources Information Center

    Montgomery County Intermediate Unit 23, Blue Bell, PA.

    The third of nine volumes in the SER-LARS (Special Education Resources Location Analysis and Retrieval System) series, a diagnostic-prescriptive instructional data bank for teachers of handicapped children, presents learning objectives organized by content descriptions. Entries give a history of the use of each objective along with information on…

  4. SER-LARS, Volume 1. User's Handbook. 1975-76 Edition.

    ERIC Educational Resources Information Center

    Montgomery County Intermediate Unit 23, Blue Bell, PA.

    The first of nine volumes in the SER-LARS (Special Education Resources Location Analysis and Retrieval System) Series presents an overview of the system's diagnostic-prescriptive instructional data bank. Information for the user is provided on resources needed, information generated, and procedures for the model's eight levels: initial referral…

  5. SER-LARS, Volume 2. Learning Objective History I. 1975-76 Edition.

    ERIC Educational Resources Information Center

    Montgomery County Intermediate Unit 23, Blue Bell, PA.

    The second of nine volumes in the SER-LARS (Special Education Resources Location Analysis and Retrieval System) series, a diagnostic-prescriptive instructional data bank for teachers of handicapped children, presents learning objectives organized by content descriptions. The volume is explained to give a history of the use of each objective along…

  6. SER-LARS, Volume 12. Instructional Methods III. 1975-76 Edition.

    ERIC Educational Resources Information Center

    Montgomery County Intermediate Unit 23, Blue Bell, PA.

    The book briefly describes several hundred instructional methods from the Special Education Resources Location Analysis and Retrieval System (SER-LARS), which are intended for use in developing and carrying out individualized programs for handicapped children. Each teaching method includes an accession number; title; author; source; teacher tasks;…

  7. SER-LARS, Volume 10. Instructional Methods I. 1975-76 Edition.

    ERIC Educational Resources Information Center

    Montgomery County Intermediate Unit 23, Blue Bell, PA.

    The book briefly describes several hundred instructional methods from the Special Education Resources Location Analysis and Retrieval System (SER-LARS), which are intended for use in developing and carrying out individualized programs for handicapped children. Each teaching method includes an accession number; title; author; source; teacher tasks;…

  8. SER-LARS, Volume 11. Instructional Methods II. 1975-76 Edition.

    ERIC Educational Resources Information Center

    Montgomery County Intermediate Unit 23, Blue Bell, PA.

    The book briefly describes several hundred instructional methods from the Special Education Resources Location Analysis and Retrieval System (SER LARS), which are intended for use in developing and carrying out individualized programs for handicapped children. Each teaching method includes an accession number; title; author; source; teacher tasks;…

  9. Anterior cruciate ligament repair with LARS (ligament advanced reinforcement system): a systematic review

    PubMed Central

    2010-01-01

    Background Injury to the anterior cruciate ligament (ACL) of the knee is common. Following complete rupture of the ACL, insufficient re-vascularization of the ligament prevents it from healing completely, creating a need for reconstruction. A variety of grafts are available for use in ACL reconstruction surgery, including synthetic grafts. Over the last two decades new types of synthetic ligaments have been developed. One of these synthetic ligaments, the Ligament Advanced Reinforcement System (LARS), has recently gained popularity. The aim of this systematic review was to assess the current best available evidence for the effectiveness of the LARS as a surgical option for symptomatic, anterior cruciate ligament rupture in terms of graft stability, rehabilitation time and return to pre-injury function. Method This systematic review included studies using subjects with symptomatic, ACL ruptures undergoing LARS reconstruction. A range of electronic databases were searched in May 2010. The methodological quality of studies was appraised with a modified version of the Law critical appraisal tool. Data relating to study characteristics, surgical times, complication rates, outcomes related to knee stability, quality of life, function, and return to sport as well as details of rehabilitation programs and timeframes were collected. Results This review identified four studies of various designs, of a moderate methodological quality. Only one case of knee synovitis was reported. Patient satisfaction with LARS was high. Graft stability outcomes were found to be inconsistent both at post operative and at follow up periods. The time frames of rehabilitation periods were poorly reported and at times omitted. Return to pre-injury function and activity was often discussed but not reported in results. Conclusions There is an emerging body of evidence for LARS with comparable complication rates to traditional surgical techniques, and high patient satisfaction scores. However, this

  10. Integrated plan for LArTPC neutrino detectors in the US

    SciTech Connect

    Baller, B.; Fleming, B.; /Fermilab

    2009-11-01

    We present an integrated R&D plan aimed at demonstrating the ability to build a very large Liquid Argon Time Projection Chamber (LArTPC), on a scale suitable for use as a Far Detector for the LBNE neutrino oscillation experiment. This plan adopts current LArTPC R&D-related activities and proposes new ones to address questions that go beyond those being answered by the current efforts. We have employed a risk evaluation strategy to identify questions that can be answered (or risks that can be mitigated) through one or more R&D steps. In summary form, the plan consists of the following pre-existing components: (1) The Materials Test Stand program, now in operation at Fermilab, addressing questions pertaining to maintenance of argon purity; (2) Existing electronics test stands at FNAL and BNL; (3) The Liquid Argon Purity Demonstrator (LAPD) now being assembled at Fermilab; (4) The ArgoNeuT prototype LArTPC, now running in the NuMI beam; (5) The MicroBooNE experiment, proposed as a physics experiment that will advance our understanding of the LArTPC technology, now completing its conceptual design phase; (6) A software development effort that is well integrated across present and planned LArTPC detectors. We are proposing to add to these efforts the following: (1) A membrane cryostat mechanical prototype to evaluate and gain expertise with this technology; (2) An installation and integration prototype, to understand issues pertaining to detector assembly, particularly in an underground environment; (3) A {approx} 5% scale electronics systems test to understand system-wide issues as well as individual component reliability. (4) A calibration test stand that would consist of a small TPC to be exposed to a test beam for calibration studies, relevant for evaluation of physics sensitivities. We have developed a timeline and milestones for achieving these goals as discussed in Section 4. The proposed activities necessary for the final design of LAr20 are complete by CD3 in

  11. Characterizing the successful student in general chemistry and physical science classes in terms of Jung's personality types as identified by the Myers-Briggs Type Indicator

    NASA Astrophysics Data System (ADS)

    Riley, Wayne David

    1998-11-01

    A student's success in a science class can depend upon previous experiences, motivation, and the level of interest in the subject. Since psychological type is intrinsic to a person's whole being, it can be influential upon the student's motivation and interests. Thus, a study of student psychological types versus the level of success in a class, as measured by a percentage, has potential to uncover certain personality characteristics which may be helpful to or which may hinder a student's learning environment. This study was initiated, using the Myers-Briggs Type Indicator, to evaluate any correlation between a student's personality type and his/her performance in a science class. A total of 1041 students from three classes: Chemistry 121/122, Chemistry 112, Physical Science 100, volunteered for the study. An analysis of variance (ANOVA) was used to determine the levels of significance among sixteen personality types' averages. The results reveal that for the Chemistry 1121/122 course, the average score of the INTJ personality type was 5.1 to 12.6 points higher than every other personality type. The ANOVA identifies 3 personality types with averages significantly below the INTJ at the p < 0.05 significance level. The ANOVA analysis for the Chemistry 112 course identified significances between student scores at p = 0.08. The significance level for the differences among scores for the Physical Science 100 course was determined at a level of p = 0.02. Significance levels for p < 0.05 and <0.01 were identified between several groups in this course. The data suggest, that although personality type may not predict a particular student's success in a science class, students with certain personality traits may be favored in a chemistry class due the structure of the instruction and the presentation of the subject matter.

  12. A study of the atmospheric dispersion of a high release of krypton-85 above a complex coastal terrain, comparison with the predictions of Gaussian models (Briggs, Doury, ADMS4).

    PubMed

    Leroy, C; Maro, D; Hébert, D; Solier, L; Rozet, M; Le Cavelier, S; Connan, O

    2010-11-01

    Atmospheric releases of krypton-85, from the nuclear fuel reprocessing plant at the AREVA NC facility at La Hague (France), were used to test Gaussian models of dispersion. In 2001-2002, the French Institute for Radiological Protection and Nuclear Safety (IRSN) studied the atmospheric dispersion of 15 releases, using krypton-85 as a tracer for plumes emitted from two 100-m-high stacks. Krypton-85 is a chemically inert radionuclide. Krypton-85 air concentration measurements were performed on the ground in the downwind direction, at distances between 0.36 and 3.3 km from the release, by neutral or slightly unstable atmospheric conditions. The standard deviation for the horizontal dispersion of the plume and the Atmospheric Transfer Coefficient (ATC) were determined from these measurements. The experimental results were compared with calculations using first generation (Doury, Briggs) and second generation (ADMS 4.0) Gaussian models. The ADMS 4.0 model was used in two configurations; one takes account of the effect of the built-up area, and the other the effect of the roughness of the surface on the plume dispersion. Only the Briggs model correctly reproduced the measured values for the width of the plume, whereas the ADMS 4.0 model overestimated it and the Doury model underestimated it. The agreement of the models with measured values of the ATC varied according to distance from the release point. For distances less than 2 km from the release point, the ADMS 4.0 model achieved the best agreement between model and measurement; beyond this distance, the best agreement was achieved by the Briggs and Doury models. PMID:20638159

  13. ATLAS LAr calorimeters readout electronics upgrade R&D for sLHC

    NASA Astrophysics Data System (ADS)

    Chen, Hucheng; ATLAS Liquid Argon Calorimeter Group

    2011-04-01

    The ATLAS Liquid Argon (LAr) calorimeters consist of an electromagnetic barrel calorimeter and two end-caps with electromagnetic, hadronic and forward calorimeters. A total of 182,468 signals are digitized and processed real-time on detector, to provide energy and time deposited in each detector element at every occurrence of the Level-1 trigger. A luminosity upgrade of the LHC will occur in the years ~2020. The current readout electronics will need to be upgraded to sustain the higher radiation levels. A completely innovative readout scheme is being developed. The front-end readout will send out data continuously at each bunch crossing through high speed radiation resistant optical links, the data will be processed real-time with the possibility of implementing trigger algorithms. This article is an overview of the R&D activities and architectural studies the ATLAS LAr Calorimeter Group is developing.

  14. Light-based triggering and reconstruction of Michel electrons in LArIAT

    NASA Astrophysics Data System (ADS)

    Foreman, W.

    2016-01-01

    The LArIAT Experiment aims to calibrate the liquid argon time projection chamber (LArTPC) using a beam of charged particles at the Fermilab Test Beam Facility. It is equipped with a novel scintillation light readout system using PMTs and custom SiPM preamplifier boards to detect light from reflector foils coated with wavelength-shifting TPB. A trigger on delayed secondary flashes of light captures events containing stopping cosmic muons together with the Michel electrons coming from their subsequent decay. This dedicated Michel trigger supplies an abundant sample of low-energy electrons throughout the detector's active volume, providing opportunities to study the combined calorimetric capabilities of the light system and the TPC. Preliminary results using scintillation light to study properties of the Michel electron sample are presented.

  15. Application of SDSM and LARS-WG for simulating and downscaling of rainfall and temperature

    NASA Astrophysics Data System (ADS)

    Hassan, Zulkarnain; Shamsudin, Supiah; Harun, Sobri

    2014-04-01

    Climate change is believed to have significant impacts on the water basin and region, such as in a runoff and hydrological system. However, impact studies on the water basin and region are difficult, since general circulation models (GCMs), which are widely used to simulate future climate scenarios, do not provide reliable hours of daily series rainfall and temperature for hydrological modeling. There is a technique named as "downscaling techniques", which can derive reliable hour of daily series rainfall and temperature due to climate scenarios from the GCMs output. In this study, statistical downscaling models are used to generate the possible future values of local meteorological variables such as rainfall and temperature in the selected stations in Peninsular of Malaysia. The models are: (1) statistical downscaling model (SDSM) that utilized the regression models and stochastic weather generators and (2) Long Ashton research station weather generator (LARS-WG) that only utilized the stochastic weather generators. The LARS-WG and SDSM models obviously are feasible methods to be used as tools in quantifying effects of climate change condition in a local scale. SDSM yields a better performance compared to LARS-WG, except SDSM is slightly underestimated for the wet and dry spell lengths. Although both models do not provide identical results, the time series generated by both methods indicate a general increasing trend in the mean daily temperature values. Meanwhile, the trend of the daily rainfall is not similar to each other, with SDSM giving a relatively higher change of annual rainfall compared to LARS-WG.

  16. Ar-Ar ages and trapped Ar components in Martian shergottites RBT 04262 and LAR 06319

    NASA Astrophysics Data System (ADS)

    Park, Jisun; Bogard, Donald D.; Nyquist, Laurence E.; Garrison, Daniel H.; Mikouchi, Takashi

    2013-11-01

    We made 39Ar-40Ar (Ar-Ar) analyses of whole rock (WR) and mineral samples of two Martian shergottites, RBT 04262 (RBT) and LAR 06319 (LAR), in order to determine their Ar-Ar ages and the 40Ar/36Ar ratios of the trapped Martian Ar they contain. All samples released trapped (excess) 40Ar and 36Ar and suggested Ar-Ar ages older than their formation ages. Because trapped Ar components having different 40Ar/36Ar were released at different extraction temperatures, we utilized only a portion of the data to derive preferred Ar-Ar ages. We obtain Ar-Ar ages of 171 ± 8 Ma for RBT plagioclase and 163 ± 13 Ma for LAR whole rock. We identify two trapped Ar components. At low temperatures, particularly for plagioclase, Trapped-A with 40Ar/36Ar 285 ± 3 was released, and we believe this is most likely absorbed terrestrial air. At high extraction temperatures, particularly for pyroxene, Trapped-B with 40Ar/36Ar 1813 ± 127 was released. The poikilitic/non-poikilitic texture of RBT and the presence of large pyroxene oikocrysts allowed a clear definition of Trapped-B. This Ar component is Martian, and its isotopic similarity to the Martian atmospheric composition suggests that it may represent Martian atmospheric Ar incorporated into the shergottite melt via crustal rocks. Trapped-B partitioned into pyroxene at a constant molar ratio of K/36ArTr = 33.2 ± 9.5 × 106 for RBT 04262, and 80 ± 21 × 106 for LAR 06319. Trapped-A mixed in different proportions with Trapped-B could give apparently intermediate trapped 40Ar/36Ar compositions commonly observed in shergottites.

  17. The receptor protein tyrosine phosphatase LAR promotes R7 photoreceptor axon targeting by a phosphatase-independent signaling mechanism

    PubMed Central

    Hofmeyer, Kerstin; Treisman, Jessica E.

    2009-01-01

    Receptor protein tyrosine phosphatases (RPTPs) control many aspects of nervous system development. At the Drosophila neuromuscular junction (NMJ), regulation of synapse growth and maturation by the RPTP LAR depends on catalytic phosphatase activity and on the extracellular ligands Syndecan and Dally-like. We show here that the function of LAR in controlling R7 photoreceptor axon targeting in the visual system differs in several respects. The extracellular domain of LAR important for this process is distinct from the domains known to bind Syndecan and Dally-like, suggesting the involvement of a different ligand. R7 targeting does not require LAR phosphatase activity, but instead depends on the phosphatase activity of another RPTP, PTP69D. In addition, a mutation that prevents dimerization of the intracellular domain of LAR interferes with its ability to promote R7 targeting, although it does not disrupt phosphatase activity or neuromuscular synapse growth. We propose that LAR function in R7 is independent of its phosphatase activity, but requires structural features that allow dimerization and may promote the assembly of downstream effectors. PMID:19889974

  18. Wire-Cell Tomographic Event Reconstruction for large LArTPCs

    NASA Astrophysics Data System (ADS)

    Qian, Xin; Viren, Brett; Zhang, Chao; Wire-Cell Team

    2016-03-01

    Event reconstruction is one of the most challenging tasks in analyzing the data from current and future large liquid argon time projection chambers (LArTPCs). The performance of the event reconstruction holds the key to many potential future discoveries with the LArTPC technology including i) searching for new CP violation in the leptonic sector, ii) determining the neutrino mass hierarchy, and iii) searching for additional light (sterile) neutrino species. In this talk, we introduce a new reconstruction method: Wire-Cell. The principle of Wire-Cell strictly follows the principle of LArTPC, that is, the same amount of ionization electrons are observed by all the wire-planes. Using both time and charge information, 3D image of the event topologies are firstly obtained. Further reconstruction steps including the clustering, tracking, and particle identifications (PID) are then directly applied to the 3D image. The principle, current status, and future development plan of Wire-Cell will be described. The results of Wire-Cell event reconstruction will be shown with an innovative web-based ``BEE'' 3D event display. This work is supported by U.S. Department of Energy, Office of Science, Office of High Energy Physics and Early Career Research program under Contract Number DE-SC0012704.

  19. LArGe R&D for active background suppression in Gerda

    NASA Astrophysics Data System (ADS)

    Agostini, M.; Barnabé-Heider, M.; Budjáš, D.; Cattadori, C.; D'Andragora, A.; Gangapshev, A.; Gusev, K.; Heisel, M.; Junker, M.; Klimenko, A.; Schönert, S.; Smolnikov, A.; Zuzel, G.

    2012-07-01

    LArGe is a GERDA low-background test facility to study novel background suppression methods in a low-background environment, for future application in the GERDA experiment. Similar to GERDA, LArGe operates bare germanium detectors submersed into liquid argon (1 m3, 1.4tons), which in addition is instrumented with photomultipliers to detect argon scintillation light. The light is used in anti-coincidence with the germanium detectors to effectively suppress background events that deposit energy in the liquid argon. The background suppression efficiency was studied in combination with a pulse shape discrimination (PSD) technique using a BEGe detector for various sources, which represent characteristic backgrounds to GERDA. Suppression factors of a few times 103 have been achieved. First background data of LArGe with a coaxial HPGe detector (without PSD) yield a background index of the order 10-2 cts/(keV-kg-y), which is at the level of the GERDA phase I design goal. As a consequence of these results, the development of an active liquid argon veto in GERDA is pursued.

  20. Operation of bare HPGe detectors in LAr/LN2 for the GERDA experiment

    NASA Astrophysics Data System (ADS)

    Barnabé Heider, M.; Cattadori, C.; Chkvorets, O.; di Vacri, A.; Gusev, K.; Schönert, S.; Shirchenko, M.

    2008-11-01

    GERDA is designed to search for 0νββ-decay of 76Ge using high purity germanium detectors (HPGe), enriched (~ 85%) in 76Ge, directly immersed in LAr which acts both as shield against γ radiation and as cooling medium. The cryostat is located in a stainless steel water tank providing an additional shield against external background. The GERDA experiment aims at a background (b) lessapprox10-3 cts/(kg-y-keV) and energy resolution (FWHM) <= 4 keV at Qββ = 2039 keV. GERDA experiment is foreseen to proceed in two phases. For Phase I, eight reprocessed enriched HPGe detectors from the past HdM [C Balysh et al., Phys. Rev. D 66 (1997) 54] and IGEX [C E Aalseth et al., Phys. of Atomic Nuclei 63 (2000) 1225] experiments (~ 18 kg) and six reprocessed natural HPGe detectors (~ 15 kg) from the Genius Test-Facility [H V Klapdor et al., HIM A 481 (2002) 149] will be deployed in strings. GERDA aims at b lessapprox 10-2 cts/(kg·keV·y). With an exposure of ~ 15 kg·y of 76Ge and resolution ~ 3.6 keV, the sensitivity on the half-life will be T0ν1/2 3 · 1025 y (90 % C.L.) corresponding to mee < 270 meV [V A Rodin et al., Nucl. Phys. A 766 (2006) 107]. In Phase II, new diodes, able to discriminate between single- and multi-site events, will be added (~ 20 kg of 76Ge with intrinsic b ~ 10-2 cts/(kg·keV·y). With an exposure of ~ 120 kg·y, it is expected T0ν1/2 > 1.5 · 1026 y (90% C.L.) corresponding to mee < 110 meV [V A Rodin et al., Nucl. Phys. A 766 (2006) 107]. Three natural p-type HPGe prototypes (different passivation layer designs) are available in the GERDA underground facility at LNGS to investigate the effect of the detector assembly (low-mass low-activity holder), of the handling procedure and of the refurbishment technology on long term stability and spectroscopy performance. The study started on prototype 1 (fully passivated on the borehole side). 60Co γ-irradiation of the detector in LAr resulted in an increase of the leakage current (LC), depending on the

  1. Briggs, Henry (1561-1630)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Mathematician, born in Worley Wood, Yorkshire, England. Professor at Cambridge, London (Gresham College) and Oxford. By pointing out how much more useful logarithms would be if (unlike JOHN NAPIER's original invention) they were to base 10, he was responsible for improving astronomers' ability to calculate. Published mathematical tables (logarithms, sines, tangents, secants) as an aid to such ca...

  2. LAr Dewar Coil Feed Frame Pipe Analysis (Structural Analysis of General Structures, SAGS)

    SciTech Connect

    Parker, A.W.; /Fermilab

    1990-01-31

    This frame pipe analysis addresses the D0 LAr dewar Condenser tube (coil) feed pipe thermal contraction stresses and moments. The configuration is shown in PEI drawing C-32545, Rev 0, and the parameters detailed in the letter of November 20, 1989, located in appendix A. Note that all other thermal considerations for these condensing coils have been made in D0 EN 3740.512-234. The conclusion of this report is the feed lines, previously deemed appropriate without detailed analysis, have been demonstrated to be adequately designed for the intended service and require no further investigation.

  3. SN-detection in LAr-TPC and the quest for (ν-Ar) cross sections

    SciTech Connect

    Cavanna, F.

    2015-05-15

    Neutrino-nucleus cross sections are of relevance to supernova astrophysics. These cross-sections can be grouped into three categories, those that affect supernova dynamics, supernova nucleosynthesis, and terrestrial supernova neutrino detection, each of which would benefit from experimental study. In this report only the relevance of an accurate knowledge of neutrino-target nucleus cross sections for SN detection will be discussed, in particular for the case of Argon, the active target material of LAr-TPC detectors currently under construction or proposed for future very massive underground experiments.

  4. Development of COTS ADC SEE Test System for the ATLAS LArCalorimeter Upgrade

    SciTech Connect

    Hu, Xue -Ye; Chen, Hu -Cheng; Chen, Kai; Mead, Joseph; Liu, Shu -Bin; An, Qi

    2014-12-01

    Radiation-tolerant, high speed, high density and low power commercial off-the-shelf (COTS) analog-to-digital converters (ADCs) are planned to be used in the upgrade to the Liquid Argon (LAr) calorimeter front end (FE) trigger readout electronics. Total ionization dose (TID) and single event effect (SEE) are two important radiation effects which need to be characterized on COTS ADCs. In our initial TID test, Texas Instruments (TI) ADS5272 was identified to be the top performer after screening a total 17 COTS ADCs from different manufacturers with dynamic range and sampling rate meeting the requirements of the FE electronics. Another interesting feature of ADS5272 is its 6.5 clock cycles latency, which is the shortest among the 17 candidates. Based on the TID performance, we have designed a SEE evaluation system for ADS5272, which allows us to further assess its radiation tolerance. In this paper, we present a detailed design of ADS5272 SEE evaluation system and show the effectiveness of this system while evaluating ADS5272 SEE characteristics in multiple irradiation tests. According to TID and SEE test results, ADS5272 was chosen to be implemented in the full-size LAr Trigger Digitizer Board (LTDB) demonstrator, which will be installed on ATLAS calorimeter during the 2014 Long Shutdown 1 (LS1).

  5. Development of COTS ADC SEE Test System for the ATLAS LArCalorimeter Upgrade

    DOE PAGESBeta

    Hu, Xue -Ye; Chen, Hu -Cheng; Chen, Kai; Mead, Joseph; Liu, Shu -Bin; An, Qi

    2014-12-01

    Radiation-tolerant, high speed, high density and low power commercial off-the-shelf (COTS) analog-to-digital converters (ADCs) are planned to be used in the upgrade to the Liquid Argon (LAr) calorimeter front end (FE) trigger readout electronics. Total ionization dose (TID) and single event effect (SEE) are two important radiation effects which need to be characterized on COTS ADCs. In our initial TID test, Texas Instruments (TI) ADS5272 was identified to be the top performer after screening a total 17 COTS ADCs from different manufacturers with dynamic range and sampling rate meeting the requirements of the FE electronics. Another interesting feature of ADS5272more » is its 6.5 clock cycles latency, which is the shortest among the 17 candidates. Based on the TID performance, we have designed a SEE evaluation system for ADS5272, which allows us to further assess its radiation tolerance. In this paper, we present a detailed design of ADS5272 SEE evaluation system and show the effectiveness of this system while evaluating ADS5272 SEE characteristics in multiple irradiation tests. According to TID and SEE test results, ADS5272 was chosen to be implemented in the full-size LAr Trigger Digitizer Board (LTDB) demonstrator, which will be installed on ATLAS calorimeter during the 2014 Long Shutdown 1 (LS1).« less

  6. R&D studies of the ATLAS LAr calorimeter readout electronics for super-LHC

    SciTech Connect

    Chen, H.

    2010-11-01

    The ATLAS Liquid Argon (LAr) calorimeters are high precision, high sensitivity and high granularity detectors. A total of 182,468 signals are digitized and processed real-time on detector, to provide energy and time deposited in each detector element at every occurrence of the L1-trigger. The current readout electronics will need to be upgraded to sustain the higher radiation levels expected with the increase of a factor 10 in luminosity at the LHC in the years {approx}2017. A completely innovative readout scheme is being developed. The front-end readout will send out data continuously at each bunch crossing through high speed radiation resistant optical links, the data will be processed real-time with the possibility of implementing trigger algorithms. This article is an overview of the R&D activities and architectural studies the ATLAS LAr Calorimeter Group is developing: front-end analog and mixed-signal ASIC design, radiation resistance optical-links in SOS, high-speed back-end processing units based on FPGA architectures and power supply distribution schemes.

  7. Catalytic domains of the LAR and CD45 protein tyrosine phosphatases from Escherichia coli expression systems: Purification and characterization for specificity and mechanism

    SciTech Connect

    Cho, Hyeongjin; Ramer, S.E.; Itoh, Michiyasu; Saito, Haruo; Walsh, C.T. ); Kitas, E.; Bannwarth, W.; Burn, P. )

    1992-01-14

    The cytoplasmic domains of two human transmembrane protein tyrosine phosphatases (PTPases), LAR and CD45, have been expressed in Escherichia coli, purified to near-homogeneity, and compared for catalytic efficiency toward several phosphotyrosine-containing peptide substrates. A 615-residue LAR fragment (LAR-D1D2) containing both tandemly repeated PTPase domains shows almost identical specific activity and high catalytic efficiency as the 40-kDa single-domain LAR-D1 fragment, consistent with a single functional active site in the 70-kDa LAR-D1D2 enzyme. A 90-kDa fragment of the human leukocyte CD45 PTPase, containing two similar tandemly repeated PTPase domains, shows parallel specificity to LAR-D1 and LAR-D1D2 with a high k{sub cat}/K{sub M} value for a phosphotyrosyl undecapeptide. Sufficient purified LAR-D1 and LAR-D1D2 PTPases were available to demonstrate enzymatic exchange of {sup 18}O from {sup 18}O{sub 4} inorganic phosphate into H{sub 2} {sup 16}O at rates of {approximately}1 {times} 10{sup {minus}2} s{sup {minus}1}. The oxygen-18 exchange probably proceeds via a phosphoenzyme intermediate. Brief incubation of all three PTPase fragments with a ({sup 32}P)phosphotyrosyl peptide substrate prior to quench with SDS sample buffer and gel electrophoresis led to autoradiographic detection of {sup 32}P-labeled enzymes. Pulse/chase studies on the LAR {sup 32}P-enzyme showed turnover of the labeled phosphoryl group.

  8. Arthroscopic single-bundle posterior cruciate ligament reconstruction: retrospective review of hamstring tendon graft versus LARS artificial ligament

    PubMed Central

    Li, Bin; Wen, Yu; Qian, Qirong; Wu, Yuli; Lin, Xiangbo

    2008-01-01

    Our objective was to compare the results of reconstruction of isolated chronic posterior cruciate ligament (PCL) injury using a four-strand hamstring graft (4SHG) and a LARS artificial ligament. Thirty-six patients were divided into a 4SHG group (n = 15) and a LARS group (n = 21). The minimum follow-up time was two years. The outcome measures used were KT-1000 measurements, the International Knee Documentation Committee (IKDC) scoring system, Lysholm knee scoring scale and Tegner activity rating. Both groups improved significantly between the preoperative and postoperative assessment in terms of the knee laxity and functional examination (P < 0.01). Meanwhile, knee stability was significantly improved in the LARS group when compared with the 4SHG group (P < 0.05); this was also the case for the Lysholm, Tegner and IKDC scores (P < 0.05). Our study indicates that using a LARS ligament for PCL reconstruction was clinically more useful than using a 4SHG in the treatment of the PCL-deficient knee. PMID:18654776

  9. The big fat LARS - a LArge Reservoir Simulator for hydrate formation and gas production

    NASA Astrophysics Data System (ADS)

    Beeskow-Strauch, Bettina; Spangenberg, Erik; Schicks, Judith M.; Giese, Ronny; Luzi-Helbing, Manja; Priegnitz, Mike; Klump, Jens; Thaler, Jan; Abendroth, Sven

    2013-04-01

    Simulating natural scenarios on lab scale is a common technique to gain insight into geological processes with moderate effort and expenses. Due to the remote occurrence of gas hydrates, their behavior in sedimentary deposits is largely investigated on experimental set ups in the laboratory. In the framework of the submarine gas hydrate research project (SUGAR) a large reservoir simulator (LARS) with an internal volume of 425 liter has been designed, built and tested. To our knowledge this is presently a word-wide unique set up. Because of its large volume it is suitable for pilot plant scale tests on hydrate behavior in sediments. That includes not only the option of systematic tests on gas hydrate formation in various sedimentary settings but also the possibility to mimic scenarios for the hydrate decomposition and subsequent natural gas extraction. Based on these experimental results various numerical simulations can be realized. Here, we present the design and the experimental set up of LARS. The prerequisites for the simulation of a natural gas hydrate reservoir are porous sediments, methane, water, low temperature and high pressure. The reservoir is supplied by methane-saturated and pre-cooled water. For its preparation an external gas-water mixing stage is available. The methane-loaded water is continuously flushed into LARS as finely dispersed fluid via bottom-and-top-located sparger. The LARS is equipped with a mantle cooling system and can be kept at a chosen set temperature. The temperature distribution is monitored at 14 reasonable locations throughout the reservoir by Pt100 sensors. Pressure needs are realized using syringe pump stands. A tomographic system, consisting of a 375-electrode-configuration is attached to the mantle for the monitoring of hydrate distribution throughout the entire reservoir volume. Two sets of tubular polydimethylsiloxan-membranes are applied to determine gas-water ratio within the reservoir using the effect of permeability

  10. Research and development for a free-running readout system for the ATLAS LAr Calorimeters at the high luminosity LHC

    NASA Astrophysics Data System (ADS)

    Hils, Maximilian

    2016-07-01

    The ATLAS Liquid Argon (LAr) Calorimeters were designed and built to measure electromagnetic and hadronic energy in proton-proton collisions produced at the Large Hadron Collider (LHC) at centre-of-mass energies up to 14 TeV and instantaneous luminosities up to 1034 cm-2 s-1. The High Luminosity LHC (HL-LHC) programme is now developed for up to 5-7 times the design luminosity, with the goal of accumulating an integrated luminosity of 3000 fb-1. In the HL-LHC phase, the increased radiation levels and an improved ATLAS trigger system require a replacement of the Front-end (FE) and Back-end (BE) electronics of the LAr Calorimeters. Results from research and development of individual components and their radiation qualification as well as the overall system design will be presented.

  11. SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.

    PubMed

    Lie, Eunkyung; Ko, Ji Seung; Choi, Su-Yeon; Roh, Junyeop Daniel; Cho, Yi Sul; Noh, Ran; Kim, Doyoun; Li, Yan; Kang, Hyeyeon; Choi, Tae-Yong; Nam, Jungyong; Mah, Won; Lee, Dongmin; Lee, Seong-Gyu; Kim, Ho Min; Kim, Hyun; Choi, Se-Young; Um, Ji Won; Kang, Myoung-Goo; Bae, Yong Chul; Ko, Jaewon; Kim, Eunjoon

    2016-01-01

    Synaptic adhesion molecules regulate various aspects of synapse development, function and plasticity. These functions mainly involve trans-synaptic interactions and positive regulations, whereas cis-interactions and negative regulation are less understood. Here we report that SALM4, a member of the SALM/Lrfn family of synaptic adhesion molecules, suppresses excitatory synapse development through cis inhibition of SALM3, another SALM family protein with synaptogenic activity. Salm4-mutant (Salm4(-/-)) mice show increased excitatory synapse numbers in the hippocampus. SALM4 cis-interacts with SALM3, inhibits trans-synaptic SALM3 interaction with presynaptic LAR family receptor tyrosine phosphatases and suppresses SALM3-dependent presynaptic differentiation. Importantly, deletion of Salm3 in Salm4(-/-) mice (Salm3(-/-); Salm4(-/-)) normalizes the increased excitatory synapse number. These results suggest that SALM4 negatively regulates excitatory synapses via cis inhibition of the trans-synaptic SALM3-LAR adhesion. PMID:27480238

  12. A test of the Suits vegetative-canopy reflectance model with LARS soybean-canopy reflectance data

    NASA Technical Reports Server (NTRS)

    Chance, J. E.; Lemaster, E. W.

    1985-01-01

    The Suits vegetative-canopy reflectance model is tested with an extensive set of field reflectance measurements made by the Laboratory for Application of Remote Sensing (LARS) for soybean canopies. The model is tested for the full hemisphere of observer directions as well as the nadir direction. The results show moderate agreement for the visible channels of the Landsat MSS and poor agreement in the near-infrared channel of Landsat MSS. An analysis of errors is given.

  13. A More Reduced Mantle Source for Enriched Shergottites; Insights from the Olivine-Phyric Shergottite Lar 06319

    NASA Technical Reports Server (NTRS)

    Peslier, A. H.; Hnatyshin, D.; Herd, C. D. K.; Walton, E. L.; Brandon, A. D.; Lapen, T. J.; Shafer, J.

    2010-01-01

    A detailed petrographic study of melt inclusions and Cr-Fe-Ti oxides of LAR 06319 leads to two main conclusions: 1) this enriched oxidized olivine- phyric shergottite represents nearly continuous crystallization of a basaltic shergottite melt, 2) the melt became more oxidized during differentiation. The first crystallized mineral assemblages record the oxygen fugacity which is closest to that of the melt s mantle source, and which is lower than generally attributed to the enriched shergottite group.

  14. Role of the addition of cabergoline to the management of acromegalic patients resistant to longterm treatment with octreotide LAR.

    PubMed

    Vilar, Lucio; Azevedo, Monalisa F; Naves, Luciana Ansaneli; Casulari, Luiz Augusto; Albuquerque, José Luciano; Montenegro, Renan M; Montenegro, Renan M; Figueiredo, Patricia; Nascimento, Gilvan C; Faria, Manuel S

    2011-06-01

    The aim of this prospective open trial was to evaluate the efficacy in normalizing IGF-I levels of the addition of cabergoline to the treatment of acromegalic patients partially responsive to Octreotide-LAR (OCT-LAR), a long acting somatotastin analog (SSA). Fifty-two patients who did not achieve hormonal control after longterm therapy (at least, 12 months) with OCT-LAR (30 mg every 28 days intramuscularly) were given cabergoline in addition to the SSA treatment. Normalization of IGF-I levels was achieved in 40.4% of patients by 6 months after the addition of cabergoline (1.0-3.0 mg/week; mean, 2.19 ± 0.64), and these patients were considered responsive. Compared to non-responsive subjects, responsive patients had significantly lower mean %ULNR-IGF-I and GH levels. However, the rate of hyperprolactinemia and positive immunohistochemical staining for PRL was similar in both groups, before the addition of cabergoline. Responsive patients were followed for at least 12 months on combination treatment and persisted with normal IGF-I levels. Patients with baseline %ULNR IGF-I up to 220% and/or GH up to 5 ng/ml were those who benefited the most from combination treatment. No patients with %ULNR-IGF-I>250% reached normalization of IGF-I levels. Our findings demonstrated that the addition of cabergoline, even at relatively low doses, is effective in both short- and long-term control of IGF-I levels in acromegalic patients partially responsive to octreotide LAR, particularly in those with mild/moderately elevated GH/IGF-levels, irrespective of prolactin status. PMID:21104199

  15. LArGe: active background suppression using argon scintillation for the Gerda 0ν β β -experiment

    NASA Astrophysics Data System (ADS)

    Agostini, M.; Barnabé-Heider, M.; Budjáš, D.; Cattadori, C.; Gangapshev, A.; Gusev, K.; Heisel, M.; Junker, M.; Klimenko, A.; Lubashevskiy, A.; Pelczar, K.; Schönert, S.; Smolnikov, A.; Zuzel, G.

    2015-10-01

    LArGe is a Gerda low-background test facility to study novel background suppression methods in a low-background environment, for future application in the Gerda experiment. Similar to Gerda, LArGe operates bare germanium detectors submersed into liquid argon (1 m^3, 1.4 tons), which in addition is instrumented with photomultipliers to detect argon scintillation light. The scintillation signals are used in anti-coincidence with the germanium detectors to effectively suppress background events that deposit energy in the liquid argon. The background suppression efficiency was studied in combination with a pulse shape discrimination (PSD) technique using a BEGe detector for various sources, which represent characteristic backgrounds to Gerda. Suppression factors of a few times 10^3 have been achieved. First background data of LArGe with a coaxial HPGe detector (without PSD) yield a background index of (0.12-4.6)× 10^{-2} cts/(keV kg year) (90 % C.L.), which is at the level of Gerda Phase I. Furthermore, for the first time we monitor the natural ^{42}Ar abundance (parallel to Gerda), and have indication for the 2ν β β -decay in natural germanium. These results show the effectivity of an active liquid argon veto in an ultra-low background environment. As a consequence, the implementation of a liquid argon veto in Gerda Phase II is pursued.

  16. Gibbon (Hylobates lar) reintroduction success in Phuket, Thailand, and its conservation benefits.

    PubMed

    Osterberg, Petra; Samphanthamit, Phamon; Maprang, Owart; Punnadee, Suwit; Brockelman, Warren Y

    2015-05-01

    We summarize the results from a long-term gibbon reintroduction project in Phuket, Thailand, and evaluate its benefits to conservation. Between October 2002 and November 2012, eight breeding families of white-handed gibbons (Hylobates lar) were returned to the wild in Khao Phra Thaew non-hunting area (KPT). Wild gibbons were extirpated from Phuket Island by the early 1980s, but the illegal wildlife trade has continued to bring young gibbons from elsewhere to the island's popular tourist areas as pets and photo props. The Gibbon Rehabilitation Project (GRP) has rescued and rehabilitated confiscated and donated captive gibbons since 1992 and aims to repopulate the island's last sizable forest area. Following unsuccessful early attempts at translocation in the 1990s, GRP has now developed specific methods for gibbon reintroduction that have led to the establishment of a small independent, reproducing population of captive-raised and wild-born gibbons on Phuket. Eleven infants have been born wild within the reintroduced population, including a second generation wild-born gibbon in September 2012. Benefits of the GRP project include restoration of the gibbon population on Phuket, rescue of illegally kept gibbons, public education, training of personnel in gibbon conservation work, and gaining experience which may prove useful in saving more severely threatened species. It is unlikely that gibbon (and other large primate) translocations will make a significant contribution to conservation of the species as a whole, and primate translocation projects should not be judged solely by this criterion. PMID:25597291

  17. Comparison of a k-Nearest-Neighbor Simulator and LARS-WG for generating daily Precipitation

    NASA Astrophysics Data System (ADS)

    Mehdizadeh, M.; Bárdossy, A.; Guenni, L.

    2009-04-01

    Weather generators are stochastic models that produce synthetic long time series of weather data from limited records of historical data with statistically similar characteristics to those of observed. Long timeseries of synthetic weather daily data, especially precipitation, are required as climate inputs to hydrological and agricultural models, in order to evaluate the performance of the associated physical systems. LARS-WG is a semi parametric weather generator that uses flexible semi-empirical distributions for the lengths of wet and dry day series and daily precipitation. On the other hand, k-Nearest Neighbor is a non parametric technique to resample data from historical records by conditioning on the preceding days (feature vector). The model finds the historical number of nearest neighbors of the current weather vector using the Euclidean distance and resamples from it their successors. To preserve the temporal persistence, the model calculates the Euclidean distance of vectors which have similar sequence of wet and dry days. The objective of this study is to evaluate the performance of these two different models in reproducing interannual variability of precipitation in three stations in Germany. Keywords: Weather generator, k-Nearest-Neighbor, LARSWG, daily precipitation

  18. Clinical Benefits of Above-Standard Dose of Octreotide LAR in Patients With Neuroendocrine Tumors for Control of Carcinoid Syndrome Symptoms: A Multicenter Retrospective Chart Review Study

    PubMed Central

    Strosberg, Jonathan R.; Benson, Al B.; Huynh, Lynn; Goldman, Jamie; Sahai, Vaibhav; Rademaker, Alfred W.; Kulke, Matthew H.

    2014-01-01

    Background. Octreotide LAR is used in patients for control of carcinoid syndrome (CS) and other symptoms of hormone hypersecretion. The aim of this study was to examine reasons for octreotide LAR dose escalation and observe CS symptom improvement in patients with neuroendocrine tumors (NETs) who underwent octreotide LAR dose escalation at three cancer referral centers. Methods. Medical records for patients with diagnosis of carcinoid or pancreatic NET who had received one dose or more of octreotide LAR above 30 mg every 4 weeks from 2000 to 2012 were reviewed. Reasons for dose escalation and symptomatic outcomes were abstracted for each patient 3 months prior to and up to 12 months following the dose escalation. Results. Of the evaluated 239 NET patients, 53% were male, mean age at first dose escalation was 60 years (standard deviation [SD]: 11 years), and mean time from octreotide LAR initiation to first dose escalation was 1.7 years (SD: 2.0 years). The primary reasons reported for dose escalation were carcinoid or hormonal syndrome (62%) or radiographic progression (28%). The most common dose changes at the first dose escalation were 40 mg every 4 weeks (71%) and 60 mg every 4 weeks (18%). Of 90 patients in whom flushing was reported prior to first dose escalation, 73 (81%) were reported to have experienced improvement or resolution of their symptoms following the dose escalation. Of 107 patients who were reported to have experienced diarrhea before the first dose escalation, 85 (79%) were reported to have experienced improvement or resolution after first dose escalation. Conclusion. The goal of improved symptom control is a common reason for dose escalation of octreotide LAR. This study suggests that escalation to above the standard dose of octreotide LAR of 30 mg every 4 weeks may result in improved CS symptom control. PMID:25096997

  19. Simulating the gas hydrate production test at Mallik using the pilot scale pressure reservoir LARS

    NASA Astrophysics Data System (ADS)

    Heeschen, Katja; Spangenberg, Erik; Schicks, Judith M.; Priegnitz, Mike; Giese, Ronny; Luzi-Helbing, Manja

    2014-05-01

    LARS, the LArge Reservoir Simulator, allows for one of the few pilot scale simulations of gas hydrate formation and dissociation under controlled conditions with a high resolution sensor network to enable the detection of spatial variations. It was designed and built within the German project SUGAR (submarine gas hydrate reservoirs) for sediment samples with a diameter of 0.45 m and a length of 1.3 m. During the project, LARS already served for a number of experiments simulating the production of gas from hydrate-bearing sediments using thermal stimulation and/or depressurization. The latest test simulated the methane production test from gas hydrate-bearing sediments at the Mallik test site, Canada, in 2008 (Uddin et al., 2011). Thus, the starting conditions of 11.5 MPa and 11°C and environmental parameters were set to fit the Mallik test site. The experimental gas hydrate saturation of 90% of the total pore volume (70 l) was slightly higher than volumes found in gas hydrate-bearing formations in the field (70 - 80%). However, the resulting permeability of a few millidarcy was comparable. The depressurization driven gas production at Mallik was conducted in three steps at 7.0 MPa - 5.0 MPa - 4.2 MPa all of which were used in the laboratory experiments. In the lab the pressure was controlled using a back pressure regulator while the confining pressure was stable. All but one of the 12 temperature sensors showed a rapid decrease in temperature throughout the sediment sample, which accompanied the pressure changes as a result of gas hydrate dissociation. During step 1 and 2 they continued up to the point where gas hydrate stability was regained. The pressure decreases and gas hydrate dissociation led to highly variable two phase fluid flow throughout the duration of the simulated production test. The flow rates were measured continuously (gas) and discontinuously (liquid), respectively. Next to being discussed here, both rates were used to verify a model of gas

  20. Stages of rootless cone formation observed within the Raudhólar cone group, Iceland

    NASA Astrophysics Data System (ADS)

    Fitch, E. P.; Hamilton, C.; Fagents, S. A.; Thordarson, T.

    2013-12-01

    Secondary (rootless) cones form when lava interacts explosively with water contained in the substrate, and represent a largely degassed, end-member system that can elucidate mechanisms of magma-water interactions in the absence of primary degassing-induced fragmentation. Rootless cones are well documented in Iceland. The Raudhólar rootless cone group, located within the ~5200-year-old Ellidaá lava flow on the south-eastern outskirts of Reykjavík, was extensively quarried during the Second World War and now provides excellent cross-sections through the tephra sequences. Taking advantage of this exposure, we performed detailed stratigraphic, grain-size, and componentry analyses, which suggest that the energetics of rootless explosions vary substantially during cone formation. The lower unit contains the most substrate sediment and is characterized by dilute pyroclastic density current deposits. The middle unit is dominated by a succession of bed-pairs, each containing a finer-grained lower layer and coarser-grained upper layer. In the upper unit, the succession grades into a welded section that caps the cone. The abundance of substrate sediment generally decreases upwards within the cone, which suggests that the efficiency of lava-substrate mixing decreased with time. In addition, clast size generally increases upwards within the cone, implying that the fragmentation energy also decreased as the rootless eruption progressed. Both lines of evidence suggest that the explosions decreased in intensity with time, likely due to the depletion of available groundwater. However, alternating fine- and coarse-grained beds imply cycles of increased and decreased fragmentation efficiency, which we attribute to groundwater recharge and depletion during the event. Therefore, this study presents a detailed look at rootless cone formation and provides the foundation for future work on this important, yet understudied, system.

  1. Spatial resolution of gas hydrate and permeability changes from ERT data in LARS simulating the Mallik gas hydrate production test

    NASA Astrophysics Data System (ADS)

    Priegnitz, Mike; Thaler, Jan; Spangenberg, Erik; Schicks, Judith M.; Abendroth, Sven

    2014-05-01

    The German gas hydrate project SUGAR studies innovative methods and approaches to be applied in the production of methane from hydrate-bearing reservoirs. To enable laboratory studies in pilot scale, a large reservoir simulator (LARS) was realized allowing for the formation and dissociation of gas hydrates under simulated in-situ conditions. LARS is equipped with a series of sensors. This includes a cylindrical electrical resistance tomography (ERT) array composed of 25 electrode rings featuring 15 electrodes each. The high-resolution ERT array is used to monitor the spatial distribution of the electrical resistivity during hydrate formation and dissociation experiments over time. As the present phases of poorly conducting sediment, well conducting pore fluid, non-conducting hydrates, and isolating free gas cover a wide range of electrical properties, ERT measurements enable us to monitor the spatial distribution of these phases during the experiments. In order to investigate the hydrate dissociation and the resulting fluid flow, we simulated a hydrate production test in LARS that was based on the Mallik gas hydrate production test (see abstract Heeschen et al., this volume). At first, a hydrate phase was produced from methane saturated saline water. During the two months of gas hydrate production we measured the electrical properties within the sediment sample every four hours. These data were used to establish a routine estimating both the local degrees of hydrate saturation and the resulting local permeabilities in the sediment's pore space from the measured resistivity data. The final gas hydrate saturation filled 89.5% of the total pore space. During hydrate dissociation, ERT data do not allow for a quantitative determination of free gas and remaining gas hydrates since both phases are electrically isolating. However, changes are resolved in the spatial distribution of the conducting liquid and the isolating phase with gas being the only mobile isolating phase

  2. SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3–LAR adhesion

    PubMed Central

    Lie, Eunkyung; Ko, Ji Seung; Choi, Su-Yeon; Roh, Junyeop Daniel; Cho, Yi Sul; Noh, Ran; Kim, Doyoun; Li, Yan; Kang, Hyeyeon; Choi, Tae-Yong; Nam, Jungyong; Mah, Won; Lee, Dongmin; Lee, Seong-Gyu; Kim, Ho Min; Kim, Hyun; Choi, Se-Young; Um, Ji Won; Kang, Myoung-Goo; Bae, Yong Chul; Ko, Jaewon; Kim, Eunjoon

    2016-01-01

    Synaptic adhesion molecules regulate various aspects of synapse development, function and plasticity. These functions mainly involve trans-synaptic interactions and positive regulations, whereas cis-interactions and negative regulation are less understood. Here we report that SALM4, a member of the SALM/Lrfn family of synaptic adhesion molecules, suppresses excitatory synapse development through cis inhibition of SALM3, another SALM family protein with synaptogenic activity. Salm4-mutant (Salm4−/−) mice show increased excitatory synapse numbers in the hippocampus. SALM4 cis-interacts with SALM3, inhibits trans-synaptic SALM3 interaction with presynaptic LAR family receptor tyrosine phosphatases and suppresses SALM3-dependent presynaptic differentiation. Importantly, deletion of Salm3 in Salm4−/− mice (Salm3−/−; Salm4−/−) normalizes the increased excitatory synapse number. These results suggest that SALM4 negatively regulates excitatory synapses via cis inhibition of the trans-synaptic SALM3–LAR adhesion. PMID:27480238

  3. Prediction of temperature and precipitation in Sudan and South Sudan by using LARS-WG in future

    NASA Astrophysics Data System (ADS)

    Chen, Hua; Guo, Jiali; Zhang, Zengxin; Xu, Chong-Yu

    2013-08-01

    Global warming has brought great pressure on the environment and livelihood conditions in Sudan and South Sudan. It is desirable to analyze and predict the change of critical climatic variables, such as temperature and precipitation, which will provide valuable reference results for future water resources planning and management in the region. The aims of this study are to test the applicability of the Long Ashton Research Station Weather Generator (LARS-WG) model in downscaling daily precipitation and daily maximum (Tmax) and daily minimum (Tmin) temperatures in Sudan and South Sudan and use it to predict future changes of precipitation; Tmin and Tmax for nine stations in Sudan and South Sudan are based on the SRA2 scenario of seven General Circulation Models (GCMs) outputs for the periods of 2011-2030, 2046-2065, and 2080-2099. The results showed that (1) the LARS-WG model produces good performance in downscaling daily precipitation and excellent performance in downscaling Tmax and Tmin in the study region; (2) downscaled precipitation from the prediction of seven GCMs showed great inconsistency in these two regions, which illustrates the great uncertainty in GCMs' results in the regions; (3) predicted precipitation in rainy season JJA (June, July, and August) based on the ensemble mean of seven GCMs showed a decreasing trend in the periods of 2011-2030, 2046-2065, and 2080-2099 in Sudan; however, an increasing trend can be found in SON (September, October, and November) in the future; (4) precipitation in South Sudan has an increasing trend in most seasons in the future except in MAM (March, April, and May) season in 2011-2030; and (5) predictions from seven GCMs showed a similar and continuous increasing trend for Tmax and Tmin in all three future periods, which will bring severe negative influence on improving livelihoods and reducing poverty in Sudan and South Sudan.

  4. Magmatic history and parental melt composition of olivine-phyric shergottite LAR 06319: Importance of magmatic degassing and olivine antecrysts in Martian magmatism

    NASA Astrophysics Data System (ADS)

    Balta, J. Brian; Sanborn, Matthew; McSween, Harry Y.; Wadhwa, Meenakshi

    2013-08-01

    Several olivine-phyric shergottites contain enough olivine that they could conceivably represent the products of closed-system crystallization of primary melts derived from partial melting of the Martian mantle. Larkman Nunatak (LAR) 06319 has been suggested to represent a close approach to a Martian primary liquid composition based on approximate equilibrium between its olivine and groundmass. To better understand the olivine-melt relationship and the evolution of this meteorite, we report the results of new petrographic and chemical analyses. We find that olivine megacryst cores are generally not in equilibrium with the groundmass, but rather have been homogenized by diffusion to Mg# 72. We have identified two unique grain types: an olivine glomerocryst and an olivine grain preserving a primary magmatic boundary that constrains the time scale of eruption to be on the order of hours. We also report the presence of trace oxide phases and phosphate compositions that suggest that the melt contained approximately 1.1% H2O and lost volatiles during cooling, also associated with an increase in oxygen fugacity upon degassing. We additionally report in situ rare earth element measurements of the various mineral phases in LAR 06319. Based on these reported trace element abundances, we estimate the oxygen fugacity in the LAR 06319 parent melt early in its crystallization sequence (i.e., at the time of crystallization of the low-Ca and high-Ca pyroxenes), the rare earth element composition of the parent melt, and those of melts in equilibrium with later formed phases. We suggest that LAR 06319 represents the product of closed-system crystallization within a shallow magma chamber, with additional olivine accumulated from a cumulate pile. We infer that the olivine megacrysts are antecrysts, derived from a single magma chamber, but not directly related to the host magma, and suggest that mixing of antecrysts within magma chambers may be a common process in Martian magmatic

  5. Phase I Study of the Anti-IGF-1R Monoclonal Antibody, Cixutumumab in Combination with Everolimus and Octreotide LAR in Advanced Low to Intermediate Grade Neuroendocrine Tumors

    PubMed Central

    Dasari, Arvind; Phan, Alexandria; Gupta, Sanjay; Rashid, Asif; Yeung, Sai-ChingJim; Hess, Kenneth; Chen, Helen; Tarco, Emily; Chen, Huiqin; Wei, Caimiao; Anh-Do, Kim; Halperin, Daniel; Meric-Bernstam, Funda; Yao, James

    2015-01-01

    Preclinical data suggest multiple roles for the insulin like growth factor receptor 1 (IGF-1R) in neuroendocrine tumors (NET) including mediating resistance to mTOR inhibitors. Everolimus, an oral mTOR inhibitor and octreotide LAR are approved for subgroups of well differentiated NET. The primary objective was to establish the safety and recommended phase II dose (RP2D) of cixutumumab, a monoclonal antibody against IGF-1R with everolimus and octreotide LAR. Patients with well differentiated NET were treated with everolimus 10 mg po daily, octreotide LAR 20 mg IM every 21 days and escalating doses of cixutumumab. An expansion cohort was enrolled at RP2D. Correlative studies included evaluation of mTOR pathway inhibition in paired tumor biopsies and effects of this combination on metabolism per indirect calorimetry. 19 patients with progressive disease, including 9 to the expansion portion were enrolled. 2 patients had dose limiting toxicities of grade 3 mucositis at cixutumumab 15 mg/kg. Long term tolerance at RP2D was problematic, the most common ≥ grade 3 adverse event (AE) being fatigue. One patient with metastatic insulinoma had a confirmed partial response while seventeen had stable disease. Median progression free survival was 43.6 weeks and median overall survival was 25.5 months. Conclusions The RP2D of this combination per predefined study protocol cixutumumab iv 10 mg/kg, octreotide LAR 20 mg IM every 21 days plus everolimus 10 mg po daily is associated with non-DLT toxicities limiting long term tolerance. Although a signal of activity was noted in this study, this will need to be reconciled with limited tolerance of the combination and data from larger studies of anti-IGF-1R monoclonal antibodies in NET that have been disappointing. PMID:25900182

  6. Rb-Sr and Sm-Nd Studies of Olivine-Phyric Shergottites RBT 04262 and LAR 06319: Isotopic Evidence for Relationship to Enriched Basaltic Shergottites

    NASA Technical Reports Server (NTRS)

    Nyquist, L.E.; Shih, C.-Y.; Reese, Y.

    2009-01-01

    RBT 04262 and LAR 06319 are two Martian meteorites recently discovered in Antarctica. Both contain abundant olivines, and were classified as olivine-phyric shergottites. A detailed petrographic study of RBT 04262 suggested it should be reclassified as a lherzolitic shergottite. However, the moderately LREE-depleted REE distribution pattern indicated that it is closely related to enriched basaltic shergottites like Shergotty, Zagami, Los Angeles, etc. In earlier studies of a similarly olivinephyric shergottite NWA 1068 which contains 21% modal olivine, it was shown that it probably was produced from an enriched basaltic shergottite magma by olivine accumulation . As for LAR 06319, recent petrographic studies suggested that it is different from either lherzolitic shergottites or the highly LREE-depleted olivine-phyric shergottites. We performed Rb-Sr and Sm-Nd isotopic analyses on RBT 04262 and LAR 06319 to determine their crystallization ages and Sr and Nd isotopic signatures, and to better understand the petrogenetic relationships between them and other basaltic, lherzolitic and depleted olivine-phyric shergottites.

  7. PoLAR Voices: Informing Adult Learners about the Science and Story of Climate Change in the Polar Regions Through Audio Podcast

    NASA Astrophysics Data System (ADS)

    Quinney, A.; Murray, M. S.; Gobroski, K. A.; Topp, R. M.; Pfirman, S. L.

    2015-12-01

    The resurgence of audio programming with the advent of podcasting in the early 2000s spawned a new medium for communicating advances in science, research, and technology. To capitalize on this informal educational outlet, the Arctic Institute of North America partnered with the International Arctic Research Center, the University of Alaska Fairbanks, and the UA Museum of the North to develop a podcast series called PoLAR Voices for the Polar Learning and Responding (PoLAR) Climate Change Education Partnership. PoLAR Voices is a public education initiative that uses creative storytelling and novel narrative structures to immerse the listener in an auditory depiction of climate change. The programs will feature the science and story of climate change, approaching topics from both the points of view of researchers and Arctic indigenous peoples. This approach will engage the listener in the holistic story of climate change, addressing both scientific and personal perspectives, resulting in a program that is at once educational, entertaining and accessible. Feedback is being collected at each stage of development to ensure the content and format of the program satisfies listener interests and preferences. Once complete, the series will be released on thepolarhub.org and on iTunes. Additionally, blanket distribution of the programs will be accomplished via radio broadcast in urban, rural and remote areas, and in multiple languages to increase distribution and enhance accessibility.

  8. First Independent Replication of the Involvement of LARS2 in Perrault Syndrome by Whole-Exome Sequencing of an Italian Family

    PubMed Central

    Soldà, Giulia; Caccia, Sonia; Robusto, Michela; Chiereghin, Chiara; Castorina, Pierangela; Ambrosetti, Umberto; Duga, Stefano; Asselta, Rosanna

    2015-01-01

    Perrault syndrome (MIM #233400) is a rare autosomal recessive disorder characterized by ovarian dysgenesis and primary ovarian insufficiency in females, and progressive hearing loss in both genders. Recently, mutations in five genes (HSD17B4, HARS2, CLPP, LARS2, and C10ORF2) were found to be responsible for Perrault syndrome, although they do not account for all cases of this genetically heterogeneous condition. We used whole-exome sequencing to identify pathogenic variants responsible for Perrault syndrome in an Italian pedigree with two affected siblings. Both patients were compound heterozygous for two novel missense variants within the mitochondrial leucyl-tRNA synthetase (LARS2), NM_015340.3:c.899C>T(p.Thr300Met) and c.1912G>A(p.Glu638Lys). Both variants co-segregated with the phenotype in the family. p.Thr300 and p.Glu638 are evolutionary conserved residues, and are located respectively within the editing domain and immediately before the catalytically important KMSKS motif. Homology modeling using as template the E. coli leucyl-tRNA synthetase provided further insights on the possible pathogenic effects of the identified variants. This represents the first independent replication of the involvement of LARS2 mutations in Perrault syndrome, contributing valuable information for the further understanding of this disease. PMID:26657938

  9. First independent replication of the involvement of LARS2 in Perrault syndrome by whole-exome sequencing of an Italian family.

    PubMed

    Soldà, Giulia; Caccia, Sonia; Robusto, Michela; Chiereghin, Chiara; Castorina, Pierangela; Ambrosetti, Umberto; Duga, Stefano; Asselta, Rosanna

    2016-04-01

    Perrault syndrome (MIM #233400) is a rare autosomal recessive disorder characterized by ovarian dysgenesis and primary ovarian insufficiency in females, and progressive hearing loss in both genders. Recently, mutations in five genes (HSD17B4, HARS2, CLPP, LARS2 and C10ORF2) were found to be responsible for Perrault syndrome, although they do not account for all cases of this genetically heterogeneous condition. We used whole-exome sequencing to identify pathogenic variants responsible for Perrault syndrome in an Italian pedigree with two affected siblings. Both patients were compound heterozygous for two novel missense variants within the mitochondrial leucyl-tRNA synthetase (LARS2): NM_015340.3:c.899C>T(p.Thr300Met) and c.1912G>A(p.Glu638Lys). Both variants cosegregated with the phenotype in the family. p.Thr300 and p.Glu638 are evolutionarily conserved residues, and are located, respectively, within the editing domain and immediately before the catalytically important KMSKS motif. Homology modeling using as template the E. coli leucyl-tRNA synthetase provided further insights on the possible pathogenic effects of the identified variants. This represents the first independent replication of the involvement of LARS2 mutations in Perrault syndrome, contributing valuable information for the further understanding of this disease. PMID:26657938

  10. The receptor protein tyrosine phosphatase HmLAR1 is up-regulated in the CNS of the adult medicinal leech following injury and is required for neuronal sprouting and regeneration.

    PubMed

    Sethi, Jasmine; Zhao, Bailey; Cuvillier-Hot, Virginie; Boidin-Wichlacz, Céline; Salzet, Michel; Macagno, Eduardo R; Baker, Michael W

    2010-12-01

    LAR-like receptor protein tyrosine phosphatases (RPTPs), which are abundantly expressed in the nervous systems of most if not all bilaterian animals thus far examined, have been implicated in regulating a variety of critical neuronal processes. These include neuronal pathfinding, adhesion and synaptogenesis during development and, in adult mammals, neuronal regeneration. Here we explored a possible role of a LAR-like RPTP (HmLAR1) in response to mechanical trauma in the adult nervous system of the medicinal leech. In situ hybridization and QPCR analyses of HmLAR1 expression in individual segmental ganglia revealed a significant up-regulation in receptor expression following CNS injury, both in situ and following a period in vitro. Furthermore, we observed up-regulation in the expression of the leech homologue of the Abelson tyrosine kinase, a putative signaling partner to LAR receptors, but not among other tyrosine kinases. The effects on neuronal regeneration were assayed by comparing growth across a nerve crush by projections of individual dorsal P neurons (P(D)) following single-cell injection of interfering RNAs against the receptor or control RNAs. Receptor RNAi led to a significant reduction in HmLAR1 expression by the injected cells and resulted in a significant decrease in sprouting and regenerative growth at the crush site relative to controls. These studies extend the role of the HmLARs from leech neuronal development to adult neuronal regeneration and provide a platform to investigate neuronal regeneration and gene regulation at the single cell level. PMID:20708686

  11. Long-term home range use in white-handed gibbons (Hylobates lar) in Khao Yai National Park, Thailand.

    PubMed

    Bartlett, Thad Q; Light, Lydia E O; Brockelman, Warren Y

    2016-02-01

    Ranging behavior is an important element of how nonhuman primates obtain sufficient resources to ensure biological maintenance and reproductive success. As most primates live in permanent social groups, group members must balance the benefits of group living with the costs of intragroup competition for resources. One way to mitigate the cost of intragroup feeding competition is to increase foraging-related travel, thereby increasing the number of patches visited. As a result we might expect home range size to increase as a function of group size. On the other hand, for perennially territorial species, ranging behavior may be constrained by the ranging requirements of territorial defense or by the location of neighboring territories, which would result in long-term stability in the size and location of a group's home range. In this study, we examined changes in range-use characteristics in one well-habituated group of white-handed gibbons (Hylobates lar) during three study periods over a 10-year span. Group size changed from five members, two adults, two juveniles, and one infant, in 1994, to two adults in 2002, and to three adults and one sub-adult in 2004. Despite inter-annual changes in core area use we found that home range location was highly stable across years. Nevertheless, home range size was larger and daily path length significantly longer in 2002 relative to 1994 when a dependent infant was present in the group. The percentage of time adults spent resting was also significantly greater in 1994 when the infant was present. These findings highlight the importance of considering group composition, in addition to group size, when evaluating the determinants of ranging behavior. We also consider the influence of individual and shared knowledge on home range stability. PMID:26456317

  12. Different Alleles of a Gene Encoding Leucoanthocyanidin Reductase (PaLAR3) Influence Resistance against the Fungus Heterobasidion parviporum in Picea abies.

    PubMed

    Nemesio-Gorriz, Miguel; Hammerbacher, Almuth; Ihrmark, Katarina; Källman, Thomas; Olson, Åke; Lascoux, Martin; Stenlid, Jan; Gershenzon, Jonathan; Elfstrand, Malin

    2016-08-01

    Despite the fact that fungal diseases are a growing menace for conifers in modern silviculture, only a very limited number of molecular markers for pathogen resistance have been validated in conifer species. A previous genetic study indicated that the resistance of Norway spruce (Picea abies) to Heterobasidion annosum s.l., a pathogenic basidiomycete species complex, is linked to a quantitative trait loci that associates with differences in fungal growth in sapwood (FGS) that includes a gene, PaLAR3, which encodes a leucoanthocyanidin reductase. In this study, gene sequences showed the presence of two PaLAR3 allelic lineages in P. abies. Higher resistance was associated with the novel allele, which was found in low frequency in the four P. abies populations that we studied. Norway spruce plants carrying at least one copy of the novel allele showed a significant reduction in FGS after inoculation with Heterobasidion parviporum compared to their half-siblings carrying no copies, indicating dominance of this allele. The amount of (+) catechin, the enzymatic product of PaLAR3, was significantly higher in bark of trees homozygous for the novel allele. Although we observed that the in vitro activities of the enzymes encoded by the two alleles were similar, we could show that allele-specific transcript levels were significantly higher for the novel allele, indicating that regulation of gene expression is responsible for the observed effects in resistance, possibly caused by differences in cis-acting elements that we observe in the promoter region of the two alleles. PMID:27317690

  13. Numerical modeling of the simulated gas hydrate production test at Mallik 2L-38 in the pilot scale pressure reservoir LARS - Applying the "foamy oil" model

    NASA Astrophysics Data System (ADS)

    Abendroth, Sven; Thaler, Jan; Klump, Jens; Schicks, Judith; Uddin, Mafiz

    2014-05-01

    In the context of the German joint project SUGAR (Submarine Gas Hydrate Reservoirs: exploration, extraction and transport) we conducted a series of experiments in the LArge Reservoir Simulator (LARS) at the German Research Centre of Geosciences Potsdam. These experiments allow us to investigate the formation and dissociation of hydrates at large scale laboratory conditions. We performed an experiment similar to the field-test conditions of the production test in the Mallik gas hydrate field (Mallik 2L-38) in the Beaufort Mackenzie Delta of the Canadian Arctic. The aim of this experiment was to study the transport behavior of fluids in gas hydrate reservoirs during depressurization (see also Heeschen et al. and Priegnitz et al., this volume). The experimental results from LARS are used to provide details about processes inside the pressure vessel, to validate the models through history matching, and to feed back into the design of future experiments. In experiments in LARS the amount of methane produced from gas hydrates was much lower than expected. Previously published models predict a methane production rate higher than the one observed in experiments and field studies (Uddin et al. 2010; Wright et al. 2011). The authors of the aforementioned studies point out that the current modeling approach overestimates the gas production rate when modeling gas production by depressurization. They suggest that trapping of gas bubbles inside the porous medium is responsible for the reduced gas production rate. They point out that this behavior of multi-phase flow is not well explained by a "residual oil" model, but rather resembles a "foamy oil" model. Our study applies Uddin's (2010) "foamy oil" model and combines it with history matches of our experiments in LARS. Our results indicate a better agreement between experimental and model results when using the "foamy oil" model instead of conventional models of gas flow in water. References Uddin M., Wright J.F. and Coombe D

  14. Vitamin D Deficiency in Children and Adolescents in Bağcılar, İstanbul

    PubMed Central

    Erol, Meltem; Yiğit, Özgül; Küçük, Suat Hayri; Bostan Gayret, Özlem

    2015-01-01

    Objective: This study aimed to evaluate the frequency of seasonal 25-hydroxyvitamin D [25(OH)D] deficiency and insufficiency in children and adolescents living in Bağcılar, district of İstanbul city. Methods: Serum vitamin D levels of 280 children aged 3-17 years old were measured at the end of winter and at the end of summer. Of the total group, vitamin D levels were re-measured in 198 subjects. Vitamin D deficiency was defined as a serum 25(OH)D level less than 15 ng/mL and insufficiency-as levels between 15 and 20 ng/mL. Patients whose vitamin D levels were less than 15 ng/mL at the end of winter were treated with 2000 units/day of vitamin D for 3 months. Results: In the “end of winter” samples, 25(OH)D deficiency was present in 80.36% of the subjects and insufficiency in 11.79%. In the “end of summer” samples, vitamin D deficiency was detected in 3.44% and insufficiency in 27.75%. Vitamin D levels in the “end of winter” samples were not significantly different between boys and girls, while “end of summer” levels were significantly lower in girls (p=0.015). Sunlight exposure was significantly higher in boys (p=0.011). The group with sufficient dairy product consumption had significantly higher vitamin D levels in both “end of summer” and “end of winter” samples. Limb pain was frequently reported in children with low vitamin D levels in the “end of winter” samples (p=0.001). Negative correlations were observed between vitamin D levels and season and also between vitamin D levels and age. Conclusion: It is essential to provide supplemental vitamin D to children and adolescents to overcome the deficiency seen especially at the end of winter. PMID:26316436

  15. From feeder dykes to scoria cones: the tectonically controlled plumbing system of the Rauðhólar volcanic chain, Northern Volcanic Zone, Iceland

    NASA Astrophysics Data System (ADS)

    Friese, Nadine; Bense, Frithjof A.; Tanner, David C.; Gústafsson, Lúðvík E.; Siegesmund, Siegfried

    2013-06-01

    The Rauðhólar volcanic chain, located in the Northern Volcanic Zone of Iceland, has been variably eroded such that, in the northern part, the original scoria cones are preserved, while the central and southern parts expose their shallow feeders. The chain thus offers insight into the inner workings of the near-surface feeder system of scoria cones. The volcanic chain was mapped in 3D using GPS. The en echelon-arranged volcanic chain can be divided into three parts: The southernmost part contains only plugs and necks with a thin pyroclastic cover as well as multi-tiered lava flows. The central part combines partially eroded scoria cones, (feeder) dyke intersections, and welded scoria interbedded within rootless and clastogenic lava flows; the welded scoria is composed of different kinds of lithics and bombs. The northern part preserves almost intact, overlapping scoria cones with voluminous lapilli-sized scoriaceous deposits. The overall dyke trend is orthogonal but shows radial patterns in individual cone complexes. Feeder dykes observed to depths of about 200 m below the volcanic chain are up to 8 m thick and flare in to conduits in the uppermost 20-50 m. The exposed shallow plumbing system shows that magma pathways through the volcanic edifice are very complex with incremental, repeated intrusions. We interpret the arcuate shape to be the result of a local change in the orientation of the stress field because the Rauðhólar volcanic chain is located within a major relay structure between volcanoes on the eastern Fremrinámur rift arm and a rift extension with grabens on the western periphery.

  16. Long-term operation of a double phase LAr LEM Time Projection Chamber with a simplified anode and extraction-grid design

    NASA Astrophysics Data System (ADS)

    Cantini, C.; Epprecht, L.; Gendotti, A.; Horikawa, S.; Murphy, S.; Natterer, G.; Periale, L.; Resnati, F.; Rubbia, A.; Sergiampietri, F.; Viant, T.; Wu, S.

    2014-03-01

    We report on the successful operation of a double phase Liquid Argon Large Electron Multiplier Time Projection Chamber (LAr LEM-TPC) equipped with two dimensional projective anodes with dimensions 10 × 10 cm2, and with a maximum drift length of 21 cm. The anodes were manufactured for the first time from a single multilayer printed circuit board (PCB). Various layouts of the readout views have been tested and optimised. In addition, the ionisation charge was efficiently extracted from the liquid to the gas phase with a single grid instead of two previously. We studied the response and the gain of the detector to cosmic muon tracks. To study long-term stability over several weeks, we continuously operated the chamber at fixed electric field settings. We reproducibly observe that after an initial decrease with a characteristic time of τ ≈ 1.6 days, the observed gain is stable. In 46 days of operation, a total of 14.6 million triggers have been collected at a stable effective gain of G∞ ~ 15 corresponding to a signal-to-noise ratio (S/N)gtrsim60 for minimum ionising tracks. During the full period, eight discharges across the LEM were observed. A maximum effective gain of 90 was also observed, corresponding to a signal-to-noise ratio (S/N)gtrsim400 for minimum ionising tracks, or S/N ≈ 10 for an energy deposition of 15 keV on a single readout channel.

  17. Octreotide LAR and tamoxifen versus tamoxifen in phase III randomize early breast cancer trials: NCIC CTG MA.14 and NSABP B-29.

    PubMed

    Chapman, Judith-Anne W; Costantino, Joseph P; Dong, Bin; Margolese, Richard G; Pritchard, Kathleen I; Shepherd, Lois E; Gelmon, Karen A; Wolmark, Norman; Pollak, Michael N

    2015-09-01

    NCIC CTG MA.14 and NSABP B-29 trials examined the addition of Octreotide LAR (OCT) to 5 years of tamoxifen (TAM). Gallbladder toxicity led to B-29 discontinuation of OCT, and MA.14 OCT administration shortened to 2 years. Median follow-up was 9.8 years for 667 MA.14 patients and 6.8 years for 893 B-29 patients. The primary endpoint was disease-free survival (DFS), defined as time from randomization to time of breast cancer recurrence; second primary cancer other than squamous or basal cell skin carcinoma, cervical carcinoma in situ, or lobular breast carcinoma in situ; or death. The primary statistical test was a univariable pooled stratified log-rank test; multivariable assessment was with Cox regression. For MA.14, 97% of patients were ≥50 years; for B-29, 62%. MA.14 patients were 53% lymph node negative (LN-) while B-29 were 100% LN-; 33% of MA.14 patients received adjuvant chemotherapy, 2% concurrently, while B-29 had 53% concurrent chemotherapy. MA.14 patients were 90% hormone receptor positive; B-29, 100%. MA.14 patients experienced 5-year DFS of 80% with TAM, 76% with TAM + OCT; B-29 patients had 5-year DFS of 88% for both arms. Pooled univariable TAM + OCT to TAM hazard ratio (HR) was 0.99 (95% CI 0.81-1.20; p = 0.69): for MA.14, HR = 0.94 (0.73-1.20; p = 0.50); for B-29, HR = 1.09 (0.80-1.50; p = 0.59). Multivariable pooled HR = 0.98 (0.81-1.20; p = 0.84). Older patients (p < 0.001), with higher T stage (p < 0.001), and LN + (p < 0.001) had shorter DFS. Addition of OCT to TAM did not significantly improve DFS; gallbladder toxicity shortened the additional administration of OCT. This does not negate targeting the insulin-IGF-I receptor family with less toxic therapeutics. PMID:26276354

  18. Octreotide LAR and tamoxifen versus tamoxifen in phase III randomize early breast cancer trials: NCIC CTG MA.14 and NSABP B-29

    PubMed Central

    Costantino, Joseph P.; Dong, Bin; Margolese, Richard G.; Pritchard, Kathleen I.; Shepherd, Lois E.; Gelmon, Karen A.; Wolmark, Norman; Pollak, Michael N.

    2015-01-01

    NCIC CTG MA.14 and NSABP B-29 trials examined the addition of Octreotide LAR (OCT) to 5 years of tamoxifen (TAM). Gallbladder toxicity led to B-29 discontinuation of OCT, and MA.14 OCT administration shortened to 2 years. Median follow-up was 9.8 years for 667 MA.14 patients and 6.8 years for 893 B-29 patients. The primary endpoint was disease-free survival (DFS), defined as time from randomization to time of breast cancer recurrence; second primary cancer other than squamous or basal cell skin carcinoma, cervical carcinoma in situ, or lobular breast carcinoma in situ; or death. The primary statistical test was a univariable pooled stratified log-rank test; multivariable assessment was with Cox regression. For MA.14, 97 % of patients were ≥50 years; for B-29, 62 %. MA.14 patients were 53 % lymph node negative (LN–) while B-29 were 100 % LN–; 33 % of MA.14 patients received adjuvant chemotherapy, 2 % concurrently, while B-29 had 53 % concurrent chemotherapy. MA.14 patients were 90% hormone receptor positive; B-29, 100 %. MA.14 patients experienced 5-year DFS of 80 % with TAM, 76 % with TAM + OCT; B-29 patients had 5-year DFS of 88 % for both arms. Pooled univariable TAM + OCT to TAM hazard ratio (HR) was 0.99 (95% CI 0.81–1.20; p = 0.69): for MA.14, HR = 0.94 (0.73–1.20; p = 0.50); for B-29, HR = 1.09 (0.80–1.50; p = 0.59). Multivariable pooled HR = 0.98 (0.81–1.20; p = 0.84). Older patients (p < 0.001), with higher T stage (p < 0.001), and LN + (p < 0.001) had shorter DFS. Addition of OCT to TAM did not significantly improve DFS; gallbladder toxicity shortened the additional administration of OCT. This does not negate targeting the insulin–IGF-I receptor family with less toxic therapeutics. PMID:26276354

  19. Path Crossings with Lars Onsager

    NASA Astrophysics Data System (ADS)

    Yang, Chen Ning

    2013-05-01

    I first heard of Onsager's name from my M.S. degree thesis adviser J. S. Wang in Kunming, China. Wang had studied the theory of order-disorder transitions with R. H. Fowler in Cambridge, England in the 1930's. He told me one day in 1944-45 that Onsager had produced an exact solution of the Ising model in two dimensions. Wang was a quiet and reserved person. But that day he was evidently quite excited. I can remember still today, half a century later, the tone of admiration bordering on agitation with which he told me about Onsager's paper. I then looked up the paper [26J, but did not understand the strategic plan of Onsager's method. Onsager seemed to have a predilection for calculating commutators at every possible turn without supplying the reasons for so doing...

  20. Myers-Briggs Personality Type and Adolescent Coping in the College Search

    ERIC Educational Resources Information Center

    Golden, Thomas Courtenay

    2009-01-01

    The college choice requires the adolescent to gather and synthesize vast amounts of information, reconcile sometimes competing personal and familial goals, and manage a range of emotions. This decision process represents a major developmental crisis with which the adolescent must cope. Scholars have noted that psychological strain and heightened…

  1. Working Effectively with Different Personality Types: A Look at the Myers-Briggs Type Indicator

    ERIC Educational Resources Information Center

    Khanagov, Diana

    2007-01-01

    In 1921, Carl Jung wrote about four different types of personality, identified 24 centuries ago by Hippocrates. He theorized that these differences were not abnormalities in personality. Instead, he maintained that human behavior is predictable and classifiable that everyone has and acts upon personal preferences, established in early childhood.…

  2. Identifying Student Potential for ICT Entrepreneurship Using Myers-Briggs Personality Type Indicators

    ERIC Educational Resources Information Center

    Johnston, Kevin A.; Andersen, Barry K.; Davidge-Pitts, Jennifer; Ostensen-Saunders, Mark

    2009-01-01

    Literature relating to personality and entrepreneurship has focused primarily on personality characteristics of traditional entrepreneurs. The focus of this study was on personality characteristics and temperaments of potential Information and Communication Technology (ICT) entrepreneurs. The main objective of the study was to evaluate the…

  3. Improving the Efficacy of On-Campus Laboratory Experiences Using the Myers-Briggs Type Indicator.

    ERIC Educational Resources Information Center

    Metcalf, Kim K.; Wilson, Martha A.

    1994-01-01

    Preservice teachers worked in groups containing diverse personalities and participated in laboratory experiences that applied classroom knowledge. Surveys indicated students considered the laboratory activities more valuable and influential than field experiences in many ways. The most diverse cohorts reported stronger, more positive feelings…

  4. Agnotology, Scientific Consensus, and the Teaching and Learning of Climate Change: A Response to Legates, Soon and Briggs

    NASA Astrophysics Data System (ADS)

    Bedford, Daniel; Cook, John

    2013-08-01

    Agnotology is a term that has been used to describe the study of ignorance and its cultural production (Proctor in Agnotology: the making and unmaking of ignorance. Stanford University Press, Stanford, 2008). For issues that are contentious in the societal realm, though largely not in the scientific realm, such as human evolution or the broad basics of human-induced climate change, it has been suggested that explicit study of relevant misinformation might be a useful teaching approach (Bedford in J Geogr 109(4):159-165, 2010). Recently, Legates et al. (Sci Educ. doi:10.1007/s11191-013-9588-3, 2013) published an aggressive critique of Bedford's (J Geogr 109(4):159-165, 2010) proposals. However, the critique is based on a comprehensive misinterpretation of Bedford's (J Geogr 109(4):159-165, 2010) paper. Consequently, Legates et al. (Sci Educ. doi:10.1007/s11191-013-9588-3, 2013) address arguments not actually made by Bedford (J Geogr 109(4):159-165, 2010). This article is a response to Legates et al. (Sci Educ. doi:10.1007/s11191-013-9588-3, 2013), and demonstrates their errors of interpretation of Bedford (J Geogr 109(4):159-165, 2010) in several key areas: the scientific consensus on climate change; misinformation and the public perception of the scientific consensus on climate change; and agnotology as a teaching tool. We conclude by arguing that, although no single peer-reviewed publication on climate change, or any other scientific issue, should be accepted without due scrutiny, the existence of a scientific consensus—especially one as overwhelming as exists for human-induced climate change—raises the level of confidence that the overall findings of that consensus are correct.

  5. Exploring the Relationship between Myers-Briggs Type and Instructional Perspectives among College Faculty across Academic Disciplines

    ERIC Educational Resources Information Center

    Moehl, Pamela J.

    2011-01-01

    Education has the opportunity to play an integral role in sustaining the health of our economy in an increasingly competitive, global market. A review of the issues and trends impacting higher education reveals growing pressure placed on faculty to advance instructional outcomes among more diverse populations. Imbedded is the challenge to create…

  6. Agnotology, Scientific Consensus, and the Teaching and Learning of Climate Change: A Response to Legates, Soon and Briggs

    ERIC Educational Resources Information Center

    Bedford, Daniel; Cook, John

    2013-01-01

    Agnotology is a term that has been used to describe the study of ignorance and its cultural production (Proctor in "Agnotology: the making and unmaking of ignorance." Stanford University Press, Stanford, 2008). For issues that are contentious in the societal realm, though largely not in the scientific realm, such as human evolution or…

  7. Lars Onsager Prize Lecture: Statistical Dynamics of Disordered Systems

    NASA Astrophysics Data System (ADS)

    Fisher, Daniel S.

    2013-03-01

    The properties of many systems are strongly affected by quenched disorder that arose from their past history but is frozen on the time scales of interest. Although equilibrium phases and phase transitions in disordered materials can be very different from their counterparts in pure systems, the most striking phenomena involve non-equilibrium dynamics. The state of understanding of some of these will be reviewed including approach to equilibrium in spin glasses and the onset of motion in driven systems such as vortices in superconductors or earthquakes on geological faults. The potential for developing understanding of short-term evolutionary dynamics of microbial populations by taking advantage of the randomness of their past histories and the biological complexities will be discussed briefly.

  8. Lars Onsager Prize: Phase transitions in massive data acquisition

    NASA Astrophysics Data System (ADS)

    Mezard, Marc

    The rapid increase in the amount of data that is presently being generated, acquired and processed opens new perspectives in many branches of science. In order to take full advantage of this « data revolution », and to turn it into a major tool for scientific discoveries, new concepts and methods need to be developed, thus allowing us to focus on the extraction of significant information. Referring to the case of compressed sensing, the talk will show how ideas and methods in statistical physics -from spin glass theory to cristal nucleation - can help design faster, less destructive, and more efficient signal acquisition protocols, with possible applications into numerous fields -from magnetic resonance imaging to astronomy, tomography, or gene interaction network reconstruction.

  9. Lars Onsager Prize Talk: Flow Equations for Hamiltonians

    NASA Astrophysics Data System (ADS)

    Wegner, Franz

    2015-03-01

    The equation dH (l) = GH (l) can describe the renormalization group equation for the Hamiltonian/Lagrangian H (l) and the generator G of the group. But it can also describe a Hamiltonian flow for bosons/fermions, which eliminates the off-diagonal matrix elements or (quasi)-particle violating terms by means of unitary transformations dH (l) / dl = [ η (l) , H (l) ] . Typically off-diagonal matrix elements are eliminated for ΔE >l - 1 / 2 . The flow equation has been applied to numerous systems (F. Wegner, J. Phys. A: Math. Gen. 39 (2006) 8221, arXiv: cond-mat/0511660; S. Kehrein, The Flow Equation Approach to Many-Particle Systems, Springer 2006), among them to the two-dimensional Hubbard-model, spin-boson models, the Anderson impurity model, QED and QCD. A simple and surprising result (as compared to that by Frohlich) is obtained for the elimination of the electron-phonon interaction yielding an attractive interaction for all energies. (P. Lenz and F. Wegner, Nucl. Phys. B482 (1996) 693; arXiv: cond-mat/9604087).

  10. Lars Onsager Prize: Topological Defects in Condensed Matter Phases

    NASA Astrophysics Data System (ADS)

    Mineev, Vladimir

    2014-03-01

    Circulation quantization in superfluid 4He and superconductors. General principles of classification of topologically stable defects in ordered media. Superfluid phases of 3He. Topology at different scales of length. Superfluids under rotation. Biaxial nematics. Nonabelian disclinations. Half-quantum vortices: 3He-A, Sr2RuO4, exciton-polariton condensates, FFLO, Super Solid.

  11. Lars Onsager Prize Lecture: A Random Walk Through Theoretical Physics

    NASA Astrophysics Data System (ADS)

    Affleck, Ian

    2012-02-01

    A historical account will be given of my efforts to apply conformal field theory techniques to experimentally relevant models of condensed matter. This began with a so far unsuccessful attempt to find the exact critical exponents for the localization transition in the integer quantum Hall effect, using techniques developed by field/string theorists. It was followed by a program to classify critical behavior of Heisenberg antiferromagnetic spin chains of arbitrary spin magnitude. It eventually led to a general theory of the low energy behavior of quantum impurity models including exact solutions for non-Fermi liquid critical points.

  12. The pre-eminence of k(cat) in the manifestation of optimal enzymic activity delineated by using the Briggs-Haldane two-step irreversible kinetic model.

    PubMed

    Brocklehurst, K; Cornish-Bowden, A

    1976-10-01

    The suggestion by Fersht [(1974) Proc. R. Soc. London Ser. B 187, 397-407] that enzymes that provide maximal rates of catalysis should be characterized by values of Ks, the dissociation constant of the enzyme-substrate complex, greater than 10 times the value of the ambient substrate concentration has been examined. 2. For such enzymes, Ks is not relevant, and attention is best focused on the relative numerical values of k(cat). (in units of s(-1) and the substrate molarity. It is necessary only that the former be about 10(10)-10(11) times the latter to ensure that the rate of product formation be diffusion-limited and thus maximal. PMID:999634

  13. The Maryland Career Course. Stage/Style Interactions: The Perry Scheme and the Myers-Briggs Type Indicator. Brief Report #3.

    ERIC Educational Resources Information Center

    Moore, William S.

    The Maryland career course is a one-credit career planning course for undecided undergraduates based on William Perry's (1970) model of intellectual and ethical development. The Perry model can be described using four major and sometimes overlapping divisions which represent a series of positions on learning, i.e., Dualism, Multiplicity,…

  14. A descriptive study of Myers-Briggs personality types of professional music educators and music therapists with comparisons to undergraduate majors.

    PubMed

    Steele, Anita Louise; Young, Sylvester

    2011-01-01

    The purpose of the current study was to determine personality types and demographic characteristics of professional music educators and music therapists. The researchers also sought to determine if personality types of professionals were consistent with undergraduate majors in those fields and personal characteristics as suggested by The Music Education National Conference (MENC) and the American Music Therapy Association (AMTA). The research of Steele and Young (2008) found strong similarities and some differences between undergraduate music education and music therapy students. The possibility that basic types extend across the life span may strengthen understanding of job satisfaction, stress, burn out and other factors affecting retention. Participants were a voluntary convenience sample of 253 music educators (n=110) and music therapists (n=143). The highest preference for music educators was Extrovert-Intuition-Feeling-Judgment (ENFJ) and the highest preference for music therapists was Introvert-Intuition-Feeling-Judgment (INFJ). The difference in the collective type of each group was their "outlook on life", which was either Extrovert or Introvert. However, both groups were the same in their secondary type functions of "NFJ". A comparison of findings with the Steele and Young (2008) study suggested small changes in personality type over time. Caution must be exercised in generalizing findings; however this descriptive investigation may serve as the basis for future studies, which should help foster a stable work force in these professions. PMID:21866713

  15. Analyzing the Relationship of Strengths to Personality Preferences and Vocational Interests Utilizing Clifton StrengthsFinder, Myers-Briggs Type Indicator, and Strong Interest Inventory

    ERIC Educational Resources Information Center

    Schenck, Paulette M.

    2009-01-01

    Throughout the history of vocational psychology, career counselors have constantly searched for, devised, and implemented practices and techniques to best prepare clients for the world of work. The purpose of this study was to explore the relationship between strengths to personality preference and vocational interests utilizing the Myers-Briggs…

  16. Hispanic College Students' Learning Styles, Personality Types, and Gender Differences: A Collective Case Study of Ten Hispanic College Students Exposed to the Myers Briggs Type Indicator

    ERIC Educational Resources Information Center

    Harris, Rachelle D.

    2014-01-01

    The research body regarding learning styles has been abundant; however, research related to Separate and Connected learning styles has not been as copious. The purpose of this qualitative study was to explore the association between learning styles, personality types, and gender differences for Hispanic college students between the ages of 18-24…

  17. Lars Onsager Prize Talk: Quantum fluids: from liquid helium to cold atoms

    NASA Astrophysics Data System (ADS)

    Pethick, Christopher

    2008-03-01

    The study of quantum liquids has led to ideas and concepts of broad applicability. I shall illustrate this by examples from the physics of liquid helium-3, heavy-fermion compounds, quark-gluon plasmas and cold atomic gases.

  18. VizieR Online Data Catalog: LARS VIII. Spatially resolved Halpha kinematics (Herenz+, 2016)

    NASA Astrophysics Data System (ADS)

    Herenz, E. C.; Gruyters, P.; Orlitova, I.; Hayes, M.; Ostlin, G.; Cannon, J. M.; Roth, M.; Bik, A.; Pardy, S.; Oti-Floranes, H.; Mas-Hesse, J. M.; Adamo, A.; Atek, H.; Duval, F.; Guaita, L.; Kunth, D.; Laursen, P.; Melinder, J.; Puschnig, J.; Rivera-Thorsen, T. E.; Schaerer, D.; Verhamme, A.

    2015-11-01

    The FITS files contain the reduced Calar-Alto 3.5m PMAS flux datacubes. Observations and datareduction are described in Sects. 2 and 3 of the paper. We also provide errorcubes and the resolving power maps that were used in our derivation of the Hα velocity fields. WCS information is included only in the fluxcubes. The cubes were registered to our HST imaging data, so the WCS information might not be correct in an absolute sense. Wavelengths are in air as measured, i.e. no barycentric correction is applied. (2 data files).

  19. Underground operation of the ICARUS T600 LAr-TPC: first results

    NASA Astrophysics Data System (ADS)

    Rubbia, C.; Antonello, M.; Aprili, P.; Baibussinov, B.; Baldo Ceolin, M.; Barzè, L.; Benetti, P.; Calligarich, E.; Canci, N.; Carbonara, F.; Cavanna, F.; Centro, S.; Cesana, A.; Cieslik, K.; Cline, D. B.; Cocco, A. G.; Dabrowska, A.; Dequal, D.; Dermenev, A.; Dolfini, R.; Farnese, C.; Fava, A.; Ferrari, A.; Fiorillo, G.; Gibin, D.; Gigli Berzolari, A.; Gninenko, S.; Golan, T.; Guglielmi, A.; Haranczyk, M.; Holeczek, J.; Karbowniczek, P.; Kirsanov, M.; Kisiel, J.; Kochanek, I.; Lagoda, J.; Lantz, M.; Mania, S.; Mannocchi, G.; Mauri, F.; Menegolli, A.; Meng, G.; Montanari, C.; Muraro, S.; Otwinowski, S.; Palamara, O.; Palczewski, T. J.; Periale, L.; Piazzoli, A.; Picchi, P.; Pietropaolo, F.; Plonski, P.; Prata, M.; Przewlocki, P.; Rappoldi, A.; Raselli, G. L.; Rossella, M.; Sala, P.; Scantamburlo, E.; Scaramelli, A.; Segreto, E.; Sergiampietri, F.; Sobczyk, J.; Stefan, D.; Stepaniak, J.; Sulej, R.; Szarska, M.; Terrani, M.; Varanini, F.; Ventura, S.; Vignoli, C.; Wachala, T.; Wang, H.; Yang, X.; Zalewska, A.; Zaremba, K.; Zmuda, J.

    2011-07-01

    Important open questions are still present in fundamental Physics and Cosmology, like the nature of Dark Matter, the matter-antimatter asymmetry and the validity of the Standard Model of particle interactions. Addressing these questions requires a new generation of massive particle detectors to explore the subatomic and astrophysical worlds. ICARUS T600 is the first large mass (760 tons) example of a new generation of detectors able to combine the imaging capabilities of the old famous ``bubble chamber'' with the excellent energy measurement of huge electronic detectors. ICARUS T600 now operates at the Gran Sasso underground laboratory and is used to study cosmic rays, neutrino oscillations and the proton decay. The potential for doing physics of this novel telescope is presented through a few examples of neutrino interactions reconstructed with unprecedented detail. Detector design and early operation are also reported.

  20. D0 Collider Detector LINDE, East Chicago (LAr Contractor) Trip Report

    SciTech Connect

    Dixon, K.; Krempetz, K.; Mulholland, G.T.; Urbin, J.; /Fermilab

    1991-02-08

    East Chicago is capable of processing air at a 6-7E6 SCFH rate. They can produce as much as 1.2E6 SCFH 02 and 4.5 SCFH N2 (not coincidently) with a peak product efficiency of 85-86% (product to total Intake). The general area demand has been as high as 10E6, as low as 4.5E6, and is currently 8E6 SCFH totaI product. The plant is really four plants in one. At anyone time one or more plants can be down for maintenance and the others online and delivering to the pipe line that distributes their product to nearby steel plants, and to the liquid reservoirs (perlite insulated tanks) of 160, 160 and 200 E6 SCF. At the time of our visit two plants were down and two were on line. The following describes the characteristics of one of the four plants. The cycle requires a base compressor (Brown Boveri, 22,600 hp) that pumps to 90-100 psig, and a booster compressor (Clark, 14,000 hp) that pumps to 300 psig. Filter houses (ca. 20-ft x 20-ft) feed the suctions and the discharge is scrubbed by dual, molecular sieve, beds 0 300 psi (6-8 hour cycle time). The beds are provided with dust blow down and down stream filter provisions. The scrubbers remove CO2, the heavy HC, and water. The effectiveness of the scrubbers is measured by the record 6 years one of the plants ran w/o the need for thawing. The thaw operation takes about 4 days. It was interesting to learn that a plant can be brought on line in two and one half hours from a warm start. Major swings from N2 rich to O2 rich production take about an hour. Argon is a small constituent in air (0.61) and thus not a major product. It comes off the main column at 761 Ar balance air components and is further purified in another column to 2% N2, 2% O2. The stream is then warmed, H2 added, and run though a palladium deoxo to combine the O2 to water. The water is removed in a dryer and the product reliquified to seperate the nitrogen. The final product is either drawn off and pumped to storage, or, in the case of case of the high purity product, pressure transfered directly from the final column to a properly cooled and purged truck backed right up to the column. The high purity product can be as low as 0.3 ppm 02 by proper application of these procedures. Liquid Argon is the only product for which standing, loaded, trailers are provided vent recovery lines. The recovered gas is fed back to the crude Ar stream. The local O2 monitoring equipment is a Teledyne 306WA with ranges of 1, 10, 100 and 1000 PPM full scale. The wet cell unit is available from ENPRO for an estimated $3,500. The N2 in Ar is measured by a special in-house Linde instrument.

  1. Lars Onsager Prize: Optimization and learning algorithms from the theory of disordered systems

    NASA Astrophysics Data System (ADS)

    Zecchina, Riccardo

    The extraction of information from large amounts of data is one of the prominent cross disciplinary challenges in contemporary science. Solving inverse and learning problems over large scale data sets requires the design of efficient optimization algorithms over very large scale networks of constraints. In such a setting, critical phenomena of the type studied in statistical physics of disordered systems often play a crucial role. This observation has lead in the last decade to a cross fertilization between statistical physics, information theory and computer science, with applications in a variety of fields. In particular a deeper geometrical understanding of the ground state structure of random computational problems and novel classes of probabilistic algorithms have emerged. In this talk I will give a brief overview of these conceptual advances and I will discuss the role that subdominant states play in the design of algorithms for large scale optimization problems. I will conclude by showing how these ideas can lead to novel applications in computational neuroscience.

  2. Cognitive Processes in the Curry Learning Style Framework as Measured by the Learning Style Profile and the Myers-Briggs Type Indicator among Non-Majors in College Biology.

    ERIC Educational Resources Information Center

    Melear, Claudia Tarver

    Curry's model of learning style framework with Claxton and Murrell's adaptations was used to study the profile of non-majors in a college biology course. The purpose of the study was to provide empirically derived data in both a qualitative and quantitative format of the non-major to improve the course. Over 600 students were administered the…

  3. D0 Silicon Upgrade: Summary of Warm-Up After Draining for the D-Zero LAr Calorimeters

    SciTech Connect

    Rucinski, Russ; /Fermilab

    1996-03-14

    After a very successful physics run, the D-Zero detector Liquid Argon Calorimeters were drained in preparation of the detector rollout. During the roll out process, the calorimeters were without cooling. Information regarding the temperatures, estimated heat transfer, and pressure maintenance are documented in this engineering note.

  4. A 12 bit 40 MSPS SAR ADC with a redundancy algorithm and digital calibration for the ATLAS LAr calorimeter readout

    NASA Astrophysics Data System (ADS)

    Zeloufi, M.

    2016-01-01

    We present a SAR ADC with a generalized redundant search algorithm offering the flexibility to relax the requirements on the DAC settling time. The redundancy also allows a digital background calibration, based on a code density analysis, to compensate for the capacitor mismatch effects. The total number of capacitors used in this architecture is limited to one half of the one in a classical SAR design. Only 211 unit capacitors were necessary to reach 12 bit resolution, and the switching algorithm is intrinsically monotonic. The design is fully differential featuring 12 bit 40 MS/s in a CMOS 130 nm 1P8M process.

  5. Prolonged life-threatening hypoglycaemia following dose escalation of octreotide LAR in a patient with malignant polysecreting pancreatic neuroendocrine tumour

    PubMed Central

    Teng, Jessie; Dowling, Anthony; Hofman, Michael S; MacIsaac, Richard J; Sachithanandan, Nirupa

    2015-01-01

    Summary This paper details the case of a 77-year-old male with refractory hypoglycaemia due to inoperable metastatic pancreatic neuroendocrine tumour (pNET) co-secreting insulin and gastrin. Multiple medical therapies were trialled with limited success, and we describe the complications experienced by our patient. Somatostatin analogues can ameliorate hypoglycaemia and may have tumour-stabilising effects; however, in our case resulted in paradoxical worsening of hypoglycaemia. This rendered our patient hospital dependent for glycaemic support including continuous dextrose infusion. Although this is a reported adverse effect with initiation of therapy, we describe successful initiation of short-acting octreotide as an inpatient followed by commencement of long-acting octreotide. Hypoglycaemic collapse occurred only after dose titration of long-acting octreotide. We outline the pitfalls of somatostatin analogue therapy and the mechanisms that may contribute to worsening hypoglycaemia. This rare side effect cannot be reliably predicted, necessitating close supervision and glucose monitoring during therapy. Our patient achieved disease stabilisation and gradual resolution of hypoglycaemia with peptide receptor radionuclide therapy (PRRT), an emerging therapeutic option for metastatic neuroendocrine tumours with high efficacy and low toxicity. We present a brief but comprehensive discussion of currently available and novel therapies for insulin secreting pNETs. Learning points Hypoglycaemia due to malignant insulin secreting pNET is frequently severe and may be life-threatening despite supportive therapies.Octreotide can ameliorate hypoglycaemia, and may have anti-proliferative and tumour-stabilising effects in malignant pNETs that are surgically unresectable.Paradoxical worsening of hypoglycaemia may occur with octreotide initiation and dose titration, necessitating close supervision and glucose monitoring.PRRT is emerging as a therapeutic option with high efficacy and low toxicity. PMID:25755880

  6. Castles in the Clouds: The Irrelevance of Vertical Scales for Most Practical Concerns

    ERIC Educational Resources Information Center

    Ho, Andrew

    2016-01-01

    This is a response to a focus article by Briggs and Peck (2015) in issue 13(2). It should have been published in issue 13(3-4) alongside a rejoinder by Briggs and Peck that did appear. Due to an oversight, it was not published there and appears here. See issue 13(3-4) for a rejoinder to this response. Briggs and Peck (2015) propose what amounts to…

  7. 78 FR 49515 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    .... James A. Hopson, Delhi, Louisiana; W. Briggs Hopson, W. Briggs Hopson, III, James W. Hopson, Mary K... group acting in concert, to retain voting shares of Delhi Bancshares, Inc., and thereby indirectly retain voting shares of Guaranty Bank & Trust Company of Delhi, Louisiana, both in Delhi,...

  8. Alternative Ways of Measuring Counselees' Jungian Psychological-Type Preferences

    ERIC Educational Resources Information Center

    Vacha-Haase, Tammi; Thompson, Bruce

    2002-01-01

    Instruments measuring Carl Jung's (1921/1971) theory of psychological types have been widely used in various counseling contexts, including career counseling, marital and family therapy, and team building. The most popular measure of types, the Myers-Briggs Type Indicator (MBTI), was developed by Katherine C. Briggs and her daughter, Isabel Briggs…

  9. Psychometric Properties of Scores on a New Measure of Psychological Type.

    ERIC Educational Resources Information Center

    Vacha-Haase, Tammi; Thompson, Bruce

    Instruments measuring Carl Jung's (1921/1971) theory of psychological types have been widely used in various counseling contexts. The most popular measure of types has been the Myers-Briggs Type Indicator (K. Briggs and I. Myers). This measure has been criticized for dichotomous scoring, forced-choice response formats, and differential gender…

  10. 78 FR 42804 - SST Truck Company, LLC, a Navistar, Inc. Company Including On-Site Leased Workers From Employee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-17

    ... of determination was published in the Federal Register on January 4, 2013 (78 FR 768). At the request... Business Machines (IBM), Akzo Nobel, US Security, ASF Logistics, LLC, Briggs Equipment, William Thomas..., ASF Logistics, LLC, Briggs Equipment, William Thomas Group, DXP Enterprises, Inc., and...

  11. Our Hidden Prejudices, on Trial

    ERIC Educational Resources Information Center

    Glenn, David

    2008-01-01

    In October 2006, a New Hampshire police officer named Michael Briggs was shot to death in an alley. His accused killer, Michael Addison, has been charged with capital murder. It is the state's first death-penalty case in more than 30 years, and it is racially fraught: Addison is African-American, and Briggs was white. New Hampshire has a long list…

  12. Developmental Advising--How? Why? Proceedings of the Region VII Conference on Academic Advising. (4th, Little Rock, Arkansas, May 15-17, 1988).

    ERIC Educational Resources Information Center

    Garnett, Donald T., Ed.

    This report of a conference on developmental advising contains the following 18 papers: "An Introduction to the Myers-Briggs Type Indicator (MBTI)" (Roberta Corder); "Computer-Assisted Advising: The Personal Touch" (Susan Aldrich, Mark Peterson, Bruce Sands); "The Freshman Survey: Phase I" (Laura Lemonine); "Integrating the Myers-Briggs Type…

  13. Evaluation of the Effects of Pasireotide LAR Administration on Lymphocele Prevention after Axillary Node Dissection for Breast Cancer: Results of a Randomized Non-Comparative Phase 2 Study

    PubMed Central

    Chéreau, Elisabeth; Uzan, Catherine; Boutmy-Deslandes, Emmanuelle; Zohar, Sarah; Bézu, Corinne; Mazouni, Chafika; Garbay, Jean-Rémi; Daraï, Emile; Rouzier, Roman

    2016-01-01

    Objective The aim of this study was to assess the efficacy (response rate centered on 80%) of a somatostatin analog with high affinity for 4 somatostatin receptors in reducing the postoperative incidence of symptomatic lymphocele formation following total mastectomy with axillary lymph node dissection. Setting This prospective, double-blind, randomised, placebo-controlled, phase 2 trial was conducted in two secondary care centres. Participants All female patients for whom mastectomy and axillary lymph node dissection were indicated were eligible for the study, including patients who had received neo-adjuvant chemotherapy. Main exclusion criteria were related to diabetes, cardiac insufficiency, disorder of cardiac conduction or hepatic failure. Interventions Patients were randomised to receive one injection of either prolonged-release pasireotide 60 mg or placebo (physiological serum), which were administered intramuscularly 7 to 10 days before the scheduled surgery. The study was conducted in a double-blind manner. Primary and Secondary Outcome Measures The primary outcome measure was the percentage of patients who did not develop post-operative axillary symptomatic lymphoceles during the 2 postoperative months. Secondary endpoints were the total quantity of lymph drained, duration and daily volume of drainage and aspirated volumes of lymph. Results Ninety-one patients were randomised. Ninety patients were evaluable: 42 patients received pasireotide, and 48 patients received placebo. The mean estimated response rate were 62.4% (95% Credibility Interval [CrI]: 48.6%-75.3%) in the treatment group and 50.2% (95% CrI: 37.6%-62.8%) in the placebo group. Overall safety was comparable across groups, and one serious adverse event occurred. In the treatment group, one patient with known insulin-depe*ndent diabetes required hospitalization for hyperglycaemia. Conclusions With this phase 2 preliminary study, even if our results indicate a trend towards a reduction in symptomatic lymphocele, pre-operative injection of pasireotide failed to achieve a response rate centered on 80%. Pharmacokinetics analysis suggests that effect of pasireotide could be optimised. Trial Registration ClinicalTrials.gov NCT01356862 PMID:27280398

  14. Lars Onsager Prize: The mean field solution for Hard Sphere Jamming and a new scenario for the low temperature landscape of glasses

    NASA Astrophysics Data System (ADS)

    Parisi, Giorgio

    In a hard spheres systems particles cannot overlap. Increasing the density we reach a point where most of the particles are blocked and the density cannot be increased any more: this is the jamming point. The jamming point separates the phase, where all the constraint can be satisfied, from an unsatifiable phase, where spheres do have to overlap. A scaling theory of the behavior around the jamming critical point has been formulated and a few critical exponents have been introduced. The exponents are apparently super-universal, as far as they do seem to be independent from the space dimensions. The mean field version of the model (i.e. the infinite dimensions limit) has been solved analytically using broken replica symmetry techniques and the computed critical exponents have been found in a remarkable agreement with three-dimensional and two-dimensional numerical results and experiments. The theory predicts in hard spheres (in glasses) a new transition (the Gardener transition) from the replica symmetric phase to the replica broken phase at high density (at low temperature), in agreement with simulations on hard sphere systems. I will briefly discuss the possible consequences of this new picture on the very low temperature behavior of glasses in the quantum regime.

  15. Lars Onsager Prize Talk: A New Challenge for Cold Atom Physics: Achieving the Strongly Correlated Regimes for Cold Atoms in Optical Lattices.

    NASA Astrophysics Data System (ADS)

    Ho, Tin-Lun

    2008-03-01

    Cold atoms in optical lattices show great promise to generate a whole host of new strongly correlated states and to emulate many theoretical models for strongly interacting electronic systems. However, to reach these strongly correlated regimes, we need to reach unprecedented low temperatures within current experimental settings. To achieve this, it is necessary to remove considerable amount of entropy from the system. Here, we point out a general principle for removing entropies of quantum gases in optical lattices which will allow one to reach some extraordinarily low temperature scales.

  16. Application of satellite data and LARS's data processing techniques to mapping vegetation of the Dismal Swamp. M.S. Thesis - Old Dominion Univ.

    NASA Technical Reports Server (NTRS)

    Messmore, J. A.

    1976-01-01

    The feasibility of using digital satellite imagery and automatic data processing techniques as a means of mapping swamp forest vegetation was considered, using multispectral scanner data acquired by the LANDSAT-1 satellite. The site for this investigation was the Dismal Swamp, a 210,000 acre swamp forest located south of Suffolk, Va. on the Virginia-North Carolina border. Two basic classification strategies were employed. The initial classification utilized unsupervised techniques which produced a map of the swamp indicating the distribution of thirteen forest spectral classes. These classes were later combined into three informational categories: Atlantic white cedar (Chamaecyparis thyoides), Loblolly pine (Pinus taeda), and deciduous forest. The subsequent classification employed supervised techniques which mapped Atlantic white cedar, Loblolly pine, deciduous forest, water and agriculture within the study site. A classification accuracy of 82.5% was produced by unsupervised techniques compared with 89% accuracy using supervised techniques.

  17. Lars Onsager Prize Talk: 1+1d conformal field theories as natural languages for asymptotically large-scale quantum computing

    NASA Astrophysics Data System (ADS)

    Friedan, Daniel

    2010-03-01

    An abstract argument is offered that the ideal physical systems for asymptotically large-scale quantum computers are near-critical quantum circuits, critical in the bulk, whose bulk universality classes are described by 1+1d conformal field theories. One in particular -- the Monster conformal field theory -- is especially ideal, because all of its bulk couplings are irrelevant.

  18. Ulysses and IMP-8 Observations of Cosmic Rays and So-lar Energetic Particles from the South Pole to the North Pole of the Sun near Solar Maximum*

    NASA Astrophysics Data System (ADS)

    McKibben, R. B.; Connell, J. J.; Lopate, C.; Zhang, M.

    2001-12-01

    The High Energy Telescope (HET) of the Ulysses COSPIN experiment measures intensities of galactic cosmic rays and solar energetic particles (SEPs) with good energy and charge resolution at energies above about 30 MeV/n. Since passing over the South Polar regions of the Sun near solar maximum in late 2000 Ulysses has been rapidly traversing solar latitude in its so-called Fast Latitude Scan (FLS), passing through perihelion near the sun's equator in May 2001. Maximum northern latitude (80.2 deg N) will be reached in October 2001. HET observations since the onset of solar activity, including the South Polar pass and the first part of the FLS, show that SEPs from large events were commonly observed at both Ulysses and Earth (IMP-8) regardless of the radial, latitudinal, or longitudinal separations between Ulysses and Earth. During the decay phases of the events intensities were often almost equal at Ulysses and IMP, even when Ulysses was over the Sun's South Pole and the associated flare site was in the northern hemisphere. This suggests that propagation of particles across the average interplanetary magnetic field in the inner heliosphere is effective enough to relax longitudinal and latitudinal particle intensity gradients within a few days. For galactic cosmic rays, observations from the FLS so far show that latitudinal gradients resulting from solar modulation at solar maximum are <1%/degree, and are in fact consistent with zero to the accuracy of our measurements. The small gradients also suggest effective propagation in the latitudinal direction. We will report observations from the continuing FLS, give a first report of Ulysses observations over the sun's North Polar Regions, and discuss the significance of the results for models of energetic charged particle propagation through the heliosphere. * This work was supported in part by NASA Contract JPL-955432 and by NASA Grant NAG5-8032.

  19. 75 FR 28663 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    ....: LAR-16308-2: Catalyst for Decomposition of Nitrogen Oxides. NASA Case No.: LAR-17245-1: Use of Beam Deflection to Control an Electron Beam Wire. NASA Case No.: LAR-17286-1: Miniature, Low-Power X-Ray Tube... Harmonic Efficiency of Laser Beam Interactions. NASA Case No.: LAR-17723-1: Device and Method for...

  20. An Operational Definition of the Steady State in Enzyme Kinetics.

    ERIC Educational Resources Information Center

    Barnsley, E. A.

    1990-01-01

    The Briggs-Haldane assumption is used as the basis for the development of a kinetic model for enzyme catalysis. An alternative definition of the steady state and examples of realistic mechanisms are provided. (KR)

  1. Developing Self-Awareness in the Managerial Career Development Process: The Value of 360-degree Feedback and the MBTI.

    ERIC Educational Resources Information Center

    McCarthy, Alma M.; Garavan, Thomas N.

    1999-01-01

    Myers Briggs Type Indicator results and 360-degree feedback reports were completed by 22 managers. A positive relationship was found between managerial effectiveness and self-awareness, indicating that self-awareness is a necessary component of management development. (SK)

  2. 78 FR 10692 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ... ANTHONY BRIGGS THOMAS MARTIN BROWN LAVINA RUTH BUCHANAN ROBERT CHRISTIAN CHEUNG ALLISON CHO MICHAEL KIM DE... HIGHFIELD TUCKER M JONSSON N STEPHAN W LEUNG JANICE T L LEVY-LANG LAURENCE MARTINE MARC MICHAEL...

  3. A Pilot Study of Personality Type Change.

    ERIC Educational Resources Information Center

    Johnson, Lee

    1980-01-01

    Used the Myers Briggs Type Indicator to measure personality type changes in three developmentally disabled adolescents before and after token economy treatment was conducted in a half-way house. (Author/DB)

  4. Asiago spectroscopic classification of PSN J13480490+6149153

    NASA Astrophysics Data System (ADS)

    Terreran, G.; Turatto, M.; Benetti, S.; Cappellaro, E.; Elias-Rosa, N.; Ochner, P.; Pastorello, A.; Tartaglia, L.; Tomasella, L.

    2015-08-01

    The Asiago Transient Classification Program (Tomasella et al. 2014, AN, 335, 841) reports the spectroscopic classification of PSN J13480490+6149153 in the galaxy UGC 8734 discovered by E. Briggs, D. Post, Jack Newton, and Tim Puckett.

  5. Human Robotic Study at Houghton Crater - virtual reality study from NASA Ames (FFC) Future Fight

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Human Robotic Study at Houghton Crater - virtual reality study from NASA Ames (FFC) Future Fight Central simulator tower L-R: Dr Geoffrey Briggs; Jen Jasper (seated); Dr Jan Akins and Mr. Tony Gross, Ames

  6. Unlocking Personality Type.

    ERIC Educational Resources Information Center

    Tieger, Paul D.

    2002-01-01

    This article examines some of the intricacies of personality types and their effect on career choices. Proposes that knowing students' Myers-Briggs personality types can help school counselors guide them down the right career path. (GCP)

  7. Preoperative, intraoperative and postoperative risk factors for anastomotic leakage after laparoscopic low anterior resection with double stapling technique anastomosis

    PubMed Central

    Kawada, Kenji; Sakai, Yoshiharu

    2016-01-01

    Anastomotic leakage (AL) is one of the most devastating complications after rectal cancer surgery. The double stapling technique has greatly facilitated intestinal reconstruction especially for anastomosis after low anterior resection (LAR). Risk factor analyses for AL after open LAR have been widely reported. However, a few studies have analyzed the risk factors for AL after laparoscopic LAR. Laparoscopic rectal surgery provides an excellent operative field in a narrow pelvic space, and enables total mesorectal excision surgery and preservation of the autonomic nervous system with greater precision. However, rectal transection using a laparoscopic linear stapler is relatively difficult compared with open surgery because of the width and limited performance of the linear stapler. Moreover, laparoscopic LAR exhibits a different postoperative course compared with open LAR, which suggests that the risk factors for AL after laparoscopic LAR may also differ from those after open LAR. In this review, we will discuss the risk factors for AL after laparoscopic LAR. PMID:27433085

  8. 77 FR 44264 - Endangered Species; Marine Mammals; Receipt of Applications for Permit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-27

    .... Species: Ring-tailed lemur (Lemur catta), Ruffed lemur (Varecia variegata), Lar gibbon (Hylobates lar... Departments and Agencies of January 21, 2009--Transparency and Open Government (74 FR 4685; January 26,...

  9. 78 FR 19743 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ....: LAR-18202-1: Method for Ground-to-Space Laser Calibration System; NASA Case No.: LAR-18132-1: Modeling of Laser Ablation and Plume Chemistry in a Boron Nitride Nanotube Production Rig; NASA Case No.:...

  10. Current and future liquid argon neutrino experiments

    SciTech Connect

    Karagiorgi, Georgia S.

    2015-05-15

    The liquid argon time projection chamber (LArTPC) detector technology provides an opportunity for precision neutrino oscillation measurements, neutrino cross section measurements, and searches for rare processes, such as SuperNova neutrino detection. These proceedings review current and future LArTPC neutrino experiments. Particular focus is paid to the ICARUS, MicroBooNE, LAr1, 2-LArTPC at CERN-SPS, LBNE, and 100 kton at Okinoshima experiments.

  11. 77 FR 54933 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ... Piezoelectric Stacks; NASA Case No.: LAR-17455-2: A Nanotube Film Electrode and an Electroactive Device Fabricated with the Nanotube Film Electrode and Methods for Making Same; NASA Case No.: LAR-17952-1: Multi... Noise; NASA Case No.: LAR-17386-1: Fine-Grained Targets for Laser Synthesis of Carbon Nanotubes;...

  12. 75 FR 33806 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-15

    ..., 2010. ADDRESSES: You may submit comments, identified by FR HMDA/LAR or Reg CC, by any of the following... (HMDA) Loan/ Application Register (LAR). Agency form number: FR HMDA-LAR. OMB control number: 7100-0247... consumer deposits, 15 minutes; annual notice of new automated teller machines (ATMs), 5 hours; ATM...

  13. Accumulation of flavanols and expression of leucoanthocyanidin reductase induced by postharvest UV-C irradiation in grape berry.

    PubMed

    Wen, P F; Ji, W; Gao, M Y; Niu, T Q; Xing, Y F; Niu, X Y

    2015-01-01

    To examine the effect of postharvest ultraviolet C (UV-C) irradiation on flavanol polyphenol accumulation in the grape berry, we investigated total flavanol polyphenol content, the enzyme activity of leucoanthocyanidin reductase (LAR), and transcription of Vv lar1 and Vv lar2 using spectrophotometry, real-time polymerase chain reaction, and western blot analysis in 5-year-old Vitis vinifera L. cv. Cabernet Sauvignon plants. Our results indicated that the accumulation of flavanol polyphenol reached its highest value when exposed to UV-C irradiation for 30 min. Additionally, UV-C irradiation induced the transcription of Vv lar1 and Vv lar2 and the synthesis of LAR1 and LAR2 proteins, resulting in increased accumulation of flavanol polyphenol in the grape berry. Moreover, these effects were associated with the length of time of UV-C irradiation. PMID:26214449

  14. Cognitive and learning styles as predictors of success on the National Board Dental Examination.

    PubMed

    Behar-Horenstein, L S; Garvan, Cynthia W; Bowman, B J; Bulosan, M; Hancock, S; Johnson, M; Mutlu, B

    2011-04-01

    Using a deidentified retrospective dataset of three cohorts of matriculated dental students, we measured the degree to which selected student attributes, the Learning Type Measure, the Myers-Briggs Type Indicator, and Dental Admission Test subtests scores predicted passage on the National Board Dental Examination (NBDE), Parts I and II. Gender, Myers-Briggs Type Indicators, and the Dental Admission Test subtests for academic average and biology were found to be predictive of passing the NBDE Part I. Gender, a Myers-Briggs Type Indicator (thinking over feeling), and the Dental Admission Test subtests on reading and biology were found to be predictive of passing the NBDE Part II. The Learning Type Measure was not found to be predictive of passing the NBDE Part I or Part II. This study holds implications for heightening faculty members' awareness of students' aptitude and cognitive attributes, for teaching, and for the admissions process. PMID:21460274

  15. Moderator variables in life stress and illness relationship.

    PubMed

    Cooley, E J; Keesey, J C

    1981-09-01

    The relationship between life stress and physical illness was examined for the effects of potential moderator variables: The Sensation-Seeking Scale, health Locus of Control Scale, and Myers-Briggs Type Indicator. The Sensation-Seeking Scale proved to be a moderator with high sensation seekers (highest quartile) showing no significant correlations between life change and illness, while low sensation seekers (lowest quartile) showed a significant correlation. The Health Locus of Control Scale failed to differentiate between correlation levels for Internals and Externals. The Myers-Briggs provided several moderator variables. Introverts, Thinking and Sensing types showed larger correlations than their Extrovert, Feeling and Intuitive counterparts. The magnitudes and significance levels of these correlations suggest that the Myers-Briggs may have further usefulness in exploring the relationship between life change and illness. PMID:7276549

  16. The new Adelaide medium frequency Doppler radar

    NASA Astrophysics Data System (ADS)

    Reid, I. M.; Vandepeer, B. G. W.; Dillon, S.; Fuller, B.

    1993-08-01

    The Buckland Park Aerial Array (35 deg S, 138 deg E) is situated about 40 km north of Adelaide on a flat coastal plain. It was designed by Basil Briggs and Graham Elford, and constructed between 1965 and 1968. The first results were published in the late 1960's. Some aspects of the history of the array are described in Briggs (1993). A new MF Doppler Radar utilizing the array has been developed. This paper describes some of the technical details of this new facility.

  17. A human leucyl-tRNA synthetase as an anticancer target

    PubMed Central

    Gao, Guangwei; Yao, Ying; Li, Kun; Mashausi, Dhahiri Saidi; Li, Dongsheng; Negi, Hema; Kamle, Suchitra; Chen, Hao; Wu, Zhenghua; Zhou, Huchen; Li, Dawei

    2015-01-01

    Several aminoacyl-tRNA synthetases have been reported to be overexpressed for charging essential aminoacyl-tRNAs in many cancer types. In this study, we aimed to explore the potential role of leucyl-tRNA synthetase (LARS) as an anticancer target. MTT assay was performed to screen inhibitors to human LARS (hsLARS) from compounds AN2690 and its derivatives, compounds 1–6, in U2OS and SKOV3 cells. The compound with the strongest inhibitory ability was further investigated for its inhibitory effect in cancer cell lines and in an animal tumor model. Additionally, a LARS-rescue experiment was performed to explore the potential target in U2OS using Western blot and flow cytometry. Luciferase reporter assay was designed to analyze the effect of of hsLARS inhibitor on p21 activation. We identified an hsLARS inhibitor (compound 2) that suppressed the proliferation of U2OS and SKOV3 cells in vitro. A LARS-rescue experiment demonstrated that the proliferation inhibition was induced by targeting intracellular LARS. In addition, the hsLARS inhibition was shown to activate the p21 early transcription and promote cell apoptosis, as well as reduce implanted EMT6 tumor progression in mice. Our results suggest that LARS might serve as a potential anticancer target through the p21 signaling pathway and that the nutritional signaling pathway may provide a valuable anticancer strategy for further investigation. PMID:26508878

  18. ELASTIC NET FOR COX'S PROPORTIONAL HAZARDS MODEL WITH A SOLUTION PATH ALGORITHM.

    PubMed

    Wu, Yichao

    2012-01-01

    For least squares regression, Efron et al. (2004) proposed an efficient solution path algorithm, the least angle regression (LAR). They showed that a slight modification of the LAR leads to the whole LASSO solution path. Both the LAR and LASSO solution paths are piecewise linear. Recently Wu (2011) extended the LAR to generalized linear models and the quasi-likelihood method. In this work we extend the LAR further to handle Cox's proportional hazards model. The goal is to develop a solution path algorithm for the elastic net penalty (Zou and Hastie (2005)) in Cox's proportional hazards model. This goal is achieved in two steps. First we extend the LAR to optimizing the log partial likelihood plus a fixed small ridge term. Then we define a path modification, which leads to the solution path of the elastic net regularized log partial likelihood. Our solution path is exact and piecewise determined by ordinary differential equation systems. PMID:23226932

  19. Update on local allergic rhinitis.

    PubMed

    Altıntoprak, Niyazi; Kar, Murat; Bayar Muluk, Nuray; Oktemer, Tugba; Ipci, Kagan; Birdane, Leman; Aricigil, Mitat; Senturk, Mehmet; Bafaqeeh, Sameer Ali; Cingi, Cemal

    2016-08-01

    We here provide an update on the literature regarding local allergic rhinitis (LAR). In reviewing LAR, we have included an updated definition, classifications, mechanisms, comorbidities, and recommendations for diagnosis and treatment for LAR, as well as the defined research areas for future evidence-based studies. LAR is a localised nasal allergic response in the absence of systemic atopy characterised by local production of specific IgE (sIgE) antibodies, a TH2 pattern of mucosal cell infiltration during natural exposure to aeroallergens, and a positive nasal allergen provocation test response, with the release of inflammatory mediators. The localised allergic response of LAR is an important topic for the study of allergies. This review provides an update on the current knowledge of LAR. PMID:27368453

  20. I, S, T, and J Grading Techniques for Es, Ns, Fs, and Ps: Insights from the MBTI on Managing the Grading Process

    ERIC Educational Resources Information Center

    Fornaciari, Charles J.; Lund Dean, Kathy

    2013-01-01

    Most instructors at least occasionally experience grading student work as a frustrating, time-consuming task. The Myers-Briggs Type Indicator (MBTI) instrument can be a powerful self-awareness tool for management educators seeking to enhance their grading techniques. Evidence suggests that many management professors prefer Extraversion (E),…

  1. Learning Progressions as Evolving Tools in Joint Enterprises for Educational Improvement

    ERIC Educational Resources Information Center

    Penuel, William R.

    2015-01-01

    In their article, "Using Learning Progressions to Design Vertical Scales that Support Coherent Inferences about Student Growth," Briggs and Peck (this issue) argue that an important goal of assessment should be "to support coherent and actionable inferences of growth." They suggest that current approaches to test design rely on…

  2. Learning Styles of African American Children Which Correspond to the MBTI.

    ERIC Educational Resources Information Center

    Melear, Claudia T.; Richardson, Susan

    Studies were undertaken in four counties in North Carolina to determine if the learning styles of African American children described by J. Hale (formerly Hale-Benson) (1986) could be identified among African American high school males through the use of the Myers Briggs Type Indicator (MBTI). Learning style differences between minority (n=184)…

  3. The Singer-Loomis Inventory of Personality: A Review and Critique.

    ERIC Educational Resources Information Center

    Shou, Priscilla

    The Singer-Loomis Inventory of Personality (SLIP) was developed by two Jungian analysts to allow examination of personality from the perspective of Jung's typology and to solve problems perceived with the Myers-Briggs Type Indicator, based on Jungian dichotomies. The SLIP is designed to clarify and describe the user's personality based on the…

  4. Teachers Are from Heaven, Students Are from Hell--True or False?

    ERIC Educational Resources Information Center

    Capretz, L. F.

    2003-01-01

    Researchers have long tried to relate personality types to teaching and learning styles. It is believed that the psychological theory behind the Myers-Briggs Type Indicator (MBTI) can help university teachers to accept variety in teaching and learning approaches. This paper makes some assertions about the personality traits of academics and…

  5. Learning Progressions, Vertical Scales, and Testable Hypotheses: Promising Intuitions and Points for Clarification

    ERIC Educational Resources Information Center

    Maul, Andrew

    2015-01-01

    Briggs and Peck [in "Using Learning Progressions to Design Vertical Scales That Support Coherent Inferences about Student Growth"] call for greater care in the conceptualization of the target attributes of students, or "what it is that is growing from grade to grade." In particular, they argue that learning progressions can…

  6. Giftedness and Psychological Type.

    ERIC Educational Resources Information Center

    Hawkins, John

    1998-01-01

    Comparison of the psychological types, as measured by the Myers-Briggs Type Indicator (MBTI), of 966 students at a public residential magnet high school for academically talented students with other gifted and traditional high school students found both magnet school students and gifted students showed a particular MBTI distribution. (DB)

  7. Psychological Type and Undergraduate Student Achievement in Pharmacy Course in Military Medical University

    ERIC Educational Resources Information Center

    Shi, Ru; Shan, Shou-qin; Tian, Jian-quan

    2007-01-01

    The Myers-Briggs Type Indicator (MBTI) was given to 264 students in an undergraduate Pharmacy course at a military medical university. Selected MBTI personality types were compared for achievement in the course using a t-test to compare total points earned. High grades were earned by students stronger in the traits of introversion (I) and judgment…

  8. Concurrent Validity of the Online Version of the Keirsey Temperament Sorter II.

    ERIC Educational Resources Information Center

    Kelly, Kevin R.; Jugovic, Heidi

    2001-01-01

    Data from the Keirsey Temperament Sorter II online instrument and Myers Briggs Type Indicator (MBTI) for 203 college freshmen were analyzed. Positive correlations appeared between the concurrent MBTI and Keirsey measures of psychological type, giving preliminary support to the validity of the online version of Keirsey. (Contains 28 references.)…

  9. Participative Planning from a Jungian Viewpoint.

    ERIC Educational Resources Information Center

    Tandy, Kathleen Quinn

    1991-01-01

    Used Jungian psychodynamics in investigation of participative community planning to enhance interpersonal cooperation, initiated primarily to aid the economic revival of Montana. Used search conference technique with Jungian psychodynamics and the Myers-Briggs Type Indicator to achieve better understanding of group economic revitalization.…

  10. Hearings Before the Select Committee on Nutrition and Human Needs of the United States Senate, Ninety-Second Congress, First Session on Nutrition and Human Needs. Part 10--Micronutrient Supplements for School Lunch Program. Hearings Held Washington, D.C., December 7, 1971.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Select Committee on Nutrition and Human Needs.

    Contents of these hearings include the statement and testimony of the following witnesses: (1) Alan Young, Research Administrator, Research and Development Division, A. H. Robins Co.; Chairman, Board of Directors, Vitamin Information Bureau; (2) Dr. Joseph M. White, Nutritional and Medical Consultant, Miles Laboratories; (3) Dr. George Briggs,…

  11. An Exploration of School Counselors' Knowledge Sharing Practices Using Diffusion of Innovation Theory, Social Exchange Theory, and Theory of Reasoned Action

    ERIC Educational Resources Information Center

    Shipp, Adria E.

    2010-01-01

    School counselors are expected to be advocates, collaborators, consultants, and leaders in their work with students, families, administrators, school staff, and community based stakeholders (ASCA, 2005; Shoffner & Briggs, 2001; Rowley, 2000). Underlying these expectations is the belief that school counselors are knowledgeable in the areas that…

  12. Psychological Type Preferences of Female Bible College Students in England

    ERIC Educational Resources Information Center

    Kay, William K.; Francis, Leslie J.

    2008-01-01

    A sample of 122 female students attending a Pentecostal Bible College in England completed Form G (Anglicised) of the Myers-Briggs Type Indicator (MBTI). The data demonstrated preferences for extraversion over introversion, for sensing over intuition, for feeling over thinking, and for judging over perceiving. The predominant type was ISFJ (16%),…

  13. Debriefing Stress.

    ERIC Educational Resources Information Center

    Hill, Jonnie L.; Lance, Cynthia G.

    2002-01-01

    Discussion pf the stress associated with the educational use of games and simulations focuses on a study of graduate students that used the Myers-Briggs Type Indicator to determine that people with certain personality types experience stress at different intensities. Also found that all participants, regardless of personality type, needed…

  14. Psychological Type Preferences of Roman Catholic Priests in the United Kingdom

    ERIC Educational Resources Information Center

    Craig, Charlotte L.; Duncan, Bruce; Francis, Leslie J.

    2006-01-01

    This study explores the psychological type profile of Roman Catholic priests. A sample of 79 priests completed the Myers-Briggs Type Indicator (Form G). The study shows that Roman Catholic priests tend to prefer introversion over extraversion, feeling over thinking and judging over perceiving. Near equal preferences are shown for sensing and…

  15. Results of a Randomized Controlled Trial of Student Success Skills

    ERIC Educational Resources Information Center

    Webb, Linda; Carey, John; Villares, Elizabeth; Wells, Craig; Sayer, Aline

    2014-01-01

    Numerous authors have reviewed research to determine which skills are considered fundamental to successful academic and social outcomes for students (Hattie, Briggs, & Purdie, 1996; Masten & Coatworth, 1998; Wang, Haertel, & Walberg, 1994; Zins, Weissberg, Wang, & Walberg, 2004). These skills include: (1) cognitive and…

  16. Some Thoughts on "Using Learning Progressions to Design Vertical Scales That Support Coherent Inferences about Student Growth"

    ERIC Educational Resources Information Center

    Kingston, Neal M.; Broaddus, Angela; Lao, Hongling

    2015-01-01

    Briggs and Peck (2015) have written a thought-provoking article on the use of learning progressions in the design of vertical scales that support inferences about student growth. Organized learning models, including learning trajectories, learning progressions, and learning maps have been the subject of research for many years, but more recently…

  17. Personality Types and Learners' Interaction in Web-Based Threaded Discussion

    ERIC Educational Resources Information Center

    Lee, JeongMin; Lee, Youngmin

    2006-01-01

    This study examined the effects of group composition based on the learners' personality types as measured by the Myers-Briggs type indicator as they interacted in threaded discussions. Three groups comprised introverts, extroverts, and mixed introvert-extrovert classifications. Ninety-six participants were divided into 24 groups of 4 participants…

  18. Student Satisfaction with Blended and Online Courses Based on Personality Type

    ERIC Educational Resources Information Center

    Bolliger, Doris U.; Erichsen, Elizabeth Anne

    2013-01-01

    The purpose of the study was to investigate differences in perceived student satisfaction in blended and online learning environments based on personality type. A total of 72 graduate students enrolled in blended and online courses at two research universities in the United States completed an abbreviated online version of the Myers-Briggs Type…

  19. A Discriminant Analysis of Majors in the College Business and Public Administration at the University of North Dakota. North Dakota Economics Studies, Number 52.

    ERIC Educational Resources Information Center

    Tedefalk, Rolf K.

    Researchers have demonstrated that particular careers attract individuals with distinct identifiable personality profiles and learning styles, and this idea is extended to the selection of majors within the College of Business and Public Administration (BPA) at the University of North Dakota. The Myers-Briggs Type Indicator (MBTI) was used both to…

  20. 78 FR 56833 - Safety Zone; Fireworks Events in Captain of the Port New York Zone

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ..., 2011 (76 FR 69614). ] Table 1 1. A DMC Network Company, Briggs Launch site: A barge Fireworks, Ellis... a 360-yard radius from the barge. Date: September 9, 2013 (Rain Date: September 10, 2013). Time: 9..., 2013 (Rain Date: September 15, 2013). Time: 8:30 p.m.-10:00 p.m. 5. Circle Line Sightseeing...

  1. Extension Administrators Approach to Conflict Management: A Study of Relationships between Conflict Management Styles and Personality Type.

    ERIC Educational Resources Information Center

    Earnest, Garee W.; McCaslin, N. L.

    1994-01-01

    Most extension district directors (n=66) who completed the Myers Briggs Type Inventory and Rahim Organizational Conflict Inventories II preferred the integrating style of conflict management. Significant relationships appeared between personality type and management style. Better understanding of types and styles can improve group dynamics, team…

  2. Temperament Styles of Children in South Korea and the United States

    ERIC Educational Resources Information Center

    Lee, Dong Hun; Oakland, Thomas; Ahn, Changgu

    2010-01-01

    Temperament styles of 4,628 South Korean children, ages 9-17, are described in reference to possible gender and age differences and compared with those of 3,200 US age peers in the light of Jung's theory of temperament as modified by Myers and Briggs, one that highlights four bipolar qualities: extroversion-introversion, practical-imaginative,…

  3. The Development and Validation of a Personality Instrument to Increase Collaboration

    ERIC Educational Resources Information Center

    Richardson, Rita Coombs; DeVaney, Thomas A.

    2008-01-01

    Understanding personality profiles can be helpful in working relationships. Situations such as co-teaching frequently pair individuals in teamwork. Turf and personality conflicts between professionals can be destructive and impede goal attainment. The Myers-Briggs Type Indicator (MBTI) is a personality measure that is based on Jung's theory of…

  4. Temperament-Based Learning Styles of Palestinian and US Children

    ERIC Educational Resources Information Center

    Oakland, Thomas; Alghorani, Mohammed Adnan; Lee, Dong Hun

    2007-01-01

    Temperament styles of 400 Palestinian children living in Gaza are described, examined for possible gender and age differences, and compared with those of 3,200 US children in light of Jung's theory of temperament as modified by Myers and Briggs. The results show that Palestinian children generally prefer practical to imaginative, feeling to…

  5. Preceptor Leadership Style and the Nursing Practicum.

    ERIC Educational Resources Information Center

    Lockwood-Rayermann, Suzy

    2003-01-01

    Preceptors' leadership characteristics influence nursing students' clinical experience. Preceptors' leadership styles can be assessed with the Myers Briggs Type Indicator or Hersey and Blanchard's Leader Behavior Analysis II instrument, which identifies four styles based on situational leadership. (Contains 25 references.) (SK)

  6. Make Your Own Snow Day!

    ERIC Educational Resources Information Center

    Robeck, Edward

    2011-01-01

    Children love snow days, even when they come during the warmest weather. In this lesson the snow isn't falling outside, it's in the classroom--thanks to "Snowflake Bentley" (Briggs Martin 1998) and several models of snowflakes. A lesson on snow demonstrates several principles of practice for using models in elementary science. Focusing on snow was…

  7. A Study of the Possibility of Using the MBTI to Place Students with Seminar Leaders in C.E.P. IV.

    ERIC Educational Resources Information Center

    Oberlin, Lynn

    Use of the Myers-Briggs Type Indicator (MBTI) in placing students with seminar leaders in an undergraduate childhood education course was investigated. Eight null hypotheses were tested individually for six areas of student perception: perception of self-in-general; self-as-teacher; self-related-to-others; others; the Childhood Education Program;…

  8. Leadership for a Time of Change.

    ERIC Educational Resources Information Center

    Hetrick, William

    In recent years, almost all major changes and innovations in education have come out of suburban or urban schools, suggesting that rural schools are more resistant to change. The Myers-Briggs Type Instrument (MBTI) was completed by 86 school administrators to examine the extent to which the psychological traits of rural administrators might…

  9. Personality Preferences of Outdoor Participants.

    ERIC Educational Resources Information Center

    Cashel, Christine; Montgomery, Diane; Lane, Suzie

    A study investigated the personality type preferences of people who voluntarily chose to participate in a structured, field-based, outdoor education program. The Myers-Briggs Type Indicator (MBTI) was administered to 87 participants prior to beginning a 10-day Wilderness Education Association outdoor leadership trip. Participants were 18-46 years…

  10. Leadership Attributes and Personality Preferences of High School Student Leaders in Health Occupations Students of America.

    ERIC Educational Resources Information Center

    Walters, Norma J.; Wilmoth, James N.

    1989-01-01

    The Leadership Opinion Questionnaire, Myers-Briggs Type Indicator, and a demographic questionnaire were administered to 115 student organization officers. The level of relationships between leadership attributes and personality preferences as well as differential leadership attributes and/or personality preference patterns were investigated.…

  11. Understanding Personality Types: Does It Matter?

    ERIC Educational Resources Information Center

    Rutsohn, Philip

    1978-01-01

    Presented is a study to determine the relationship between personality and student responsiveness to a particular learning technique. The Myers-Briggs Type Indicator was used to indicate student personality; the seminar approach with varying degrees of structure and leadership was the basic classroom technique. (JMD)

  12. Are Administrators' Personalities Related to Their Job Skills?

    ERIC Educational Resources Information Center

    Wendel, Frederick C.; And Others

    1991-01-01

    According to one study, hiring officials wishing to know administrator candidates' job skills cannot learn about them from administering the Myers Briggs Type Indicator and cannot learn much about personality preferences from NASSP Assessment Center data. Hiring officials should use multiple information sources, select appropriate measurement…

  13. A Study of the Relationship between Tutor's Personality and Teaching Effectiveness: Does Culture Make a Difference?

    ERIC Educational Resources Information Center

    Chan, Bobbie

    2002-01-01

    The Chinese Personality Assessment Inventory was completed by 59 Hong Kong open university tutors who had completed the Myers-Briggs Type Indicator (MBTI). Results were compared with student evaluations of teaching, indicating that Renqing (social favors), face, harmony, and leadership predicted teaching effectiveness. Facets derived from Chinese…

  14. Honors Students as Philosophers and Detectives

    ERIC Educational Resources Information Center

    Briggs, Kaitlin A.

    2013-01-01

    This article explores the multiple educational uses of the question, "what do you mean by_____?" as an interlocutor's conversational gesture during classroom discussion, as a text-based prompt for both encoding/writing and decoding/reading, and as a rhetorical device for an effective oral presentation. Kaitlin Briggs explains that the…

  15. Use of the MBTI as a Predictor of Successful Academic and Military Performance at the United States Coast Guard Academy. Report 10-93.

    ERIC Educational Resources Information Center

    O'Connor, John C., III

    This study provides an analysis of a random sample of 100 cadets from the United States Coast Guard Academy class of 1993. Emphasis is placed on the cadets' academic achievements, their military performance, and their resignation status to determine whether the Myers-Briggs Type Indicator (MBTI) preferences can be used to predict success in these…

  16. A Comparison of Osteopathic, Pharmacy, Physical Therapy, Physician Assistant and Occupational Therapy Students' Personality Styles: Implications for Education and Practice.

    ERIC Educational Resources Information Center

    Hardigan, Patrick C.; Cohen, Stanley R.

    This study compared personality traits of students in five health professions. The Myers-Briggs Type Indicator was completed by 1,508 osteopathic students, 654 pharmacy students, 165 physical therapy students, 211 physician assistant students, and 70 occupational therapy students. Comparing the extrovert/introvert dimension revealed that pharmacy…

  17. Relationship Between Student Instructional Ratings and Student-Faculty Psychological Types.

    ERIC Educational Resources Information Center

    Blank, Logan F.

    Previous research has found little or no relationship between student instructional ratings and numerous academic and personal variables. This study sought to determine if such ratings are related to student and instructor psychological types. Undergraduate engineering students (297) and nine instructors were administered the Myers-Briggs Type…

  18. An Exercise of Self Examination That Exposes Societal Influences on Diversity Leadership

    ERIC Educational Resources Information Center

    Webster-Smith, Angela

    2008-01-01

    Leadership programs routinely offer candidates self-assessment instruments such as the Myers-Brigg Type Indicator to help them identify their probable leadership traits, leadership styles and other personality constructs. One routinely overlooked yet crucial component of school leadership programs is self examination that includes the development…

  19. A Profile and Perceptions of Fraternity Little Sister Auxiliary Groups.

    ERIC Educational Resources Information Center

    Scott, Peggy S.; Saracino, Marie

    1994-01-01

    Examined fraternity little sister auxiliary group members' perceptions of fraternity-related roles/experiences, and identified personality types of women who join such groups. Subjects (n=49) completed Auxiliary Group Questionnaire and Myers-Briggs Type Inventory. Results revealed that 83% of subjects could be classified as extraverted personality…

  20. Real-Data Simulation of Computerized Adaptive Bayesian Scaling.

    ERIC Educational Resources Information Center

    Jones, W. Paul

    1993-01-01

    Investigated model for reducing time for administration of Myers-Briggs Type Indicator (MBTI) using real-data simulation of Bayesian scaling in computerized adaptive administration. Findings from simulation study using data from 127 undergraduates are strongly supportive of use of Bayesian scaled computerized adaptive administration of MBTI.…

  1. An Examination of Self-Directed Learning Readiness in Executive-Level Fire Officers

    ERIC Educational Resources Information Center

    Knight, Steven G.

    2012-01-01

    The purpose of this study was to examine the self-directed learning readiness in executive fire officers in relation to the independent variables of personality type, educational attainment, and professional designation. This research utilized a quantitative design. This study utilized the Myers-Briggs Type Indicator (MBTI) and the Self-Directed…

  2. Applications of Jungian Type Theory to Counselor Education.

    ERIC Educational Resources Information Center

    Dilley, Josiah S.

    1987-01-01

    Describes Carl Jung's theory of psychological type and the Myers-Briggs Type Indicator (MBTI), an instrument to assess Jungian type. Cites sources of information on the research and application of the theory and the MBTI. Explores how knowledge of type theory can be useful to counselor educators. (Author)

  3. Relationship of Personality Traits to Student Retention

    ERIC Educational Resources Information Center

    Liang, John Paul

    2010-01-01

    Carl Jung's theory of psychological types has been the basis for the development of personality categorization, including tests such as Myers-Briggs Type Indicator (MBTI). This study analyzed the extent of the relationship between MBTI and Tinto (1993) retention factors that influence Oriental medicine students' choice of staying or dropping out…

  4. Prediction of Achievement in Clinical Pharmacy Courses

    ERIC Educational Resources Information Center

    Simon, Lee S.

    1978-01-01

    A study sought to identify student characteristics which account for academic achievement in clinical pharmacy courses. Preclinical grade point average was the best predictor. Subscales of the California Personality Inventory and the Myers-Briggs Type Indicator, work experience, sex, and age were the other predictor variables. (SW)

  5. The Scholarly Process: A Grounded Theory Exploring How Counselor Educators Promote Scholarship of Counselors-in-Training

    ERIC Educational Resources Information Center

    Michalak, Megan B.

    2013-01-01

    The demand for master's level counseling scholarship is on the rise as a call for evidenced based practices persist (Benishek, 1998; Briggs & Pehrsson, 2008; Huber & Savage, 2009). Although there is a demand to increase the amount of counseling produced scholarship, little examination exists regarding how the profession can begin to…

  6. A Study of School Leaders and How They Impact Classroom Use of Technology

    ERIC Educational Resources Information Center

    Downs, Robert

    2011-01-01

    The purpose of this study was to examine the relationship between a principal's personality type and a school's classroom use of technology. Myers Briggs Type Indicator data was collected from 48 principals in a large suburban district in the Metro Atlanta area, as well as, observational data documenting student use of technology. The…

  7. 78 FR 40498 - Public Land Order No. 7817; Extension of Public Land Order No. 6986; Oregon

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    .... 6986 (58 FR 35408 (1993)), which withdrew approximately 4,239.95 acres of National Forest System land... located in the Rogue River-Siskiyou National Forest between the mouth of Deer Creek and the mouth of... mouth of Deer Creek and the mouth of Briggs Creek located in the Rogue-Siskiyou National Forest....

  8. A Quasi-Linear Model of Design Cognition

    ERIC Educational Resources Information Center

    Phuthi, N.; Kumar, K. L.; Molwane, O. B.

    2010-01-01

    The continuum of human learning has been the subject of research by behaviourists, cognitivists, constructivists and lately by neural scientists among others. The style and order of learning have also been identified, notably by Benjamin Bloom et al (1956) and Gagne and Briggs (1992). Skills-learning has been the subject of attention in…

  9. NEGROES IN APPRENTICESHIP. MANPOWER AUTOMATION RESEARCH MONOGRAPH NO. 6.

    ERIC Educational Resources Information Center

    Manpower Administration (DOL), Washington, DC.

    SELECTED PORTIONS OF A STUDY, "NEGRO PARTICIPATION IN APPRENTICESHIP PROGRAMS" (VT 004 310) BY F.R. MARSHALL AND V. M. BRIGGS, JR., ARE PRESENTED TO FOSTER ACTION TO AFFORD FULLY EQUAL APPRENTICESHIP OPPORTUNITY. APPRENTICESHIP PROGRAMS IN NEW YORK, PHILADELPHIA, CLEVELAND, PITTSBURGH, CINCINNATI, DETROIT, SAN FRANCISCO-OAKLAND, HOUSTON, ATLANTA,…

  10. Adapting Item Format for Cultural Effects in Translated Tests: Cultural Effects on Construct Validity of the Chinese Versions of the MBTI

    ERIC Educational Resources Information Center

    Osterlind, Steven J.; Miao, Danmin; Sheng, Yanyan; Chia, Rosina C.

    2004-01-01

    This study investigated the interaction between different cultural groups and item type, and the ensuing effect on construct validity for a psychological inventory, the Myers-Briggs Type Indicator (MBTI, Form G). The authors analyzed 94 items from 2 Chinese-translated versions of the MBTI (Form G) for factorial differences among groups of…