Science.gov

Sample records for life qol-dn identifies

  1. Norfolk QOL-DN: validation of a patient reported outcome measure in transthyretin familial amyloid polyneuropathy.

    PubMed

    Vinik, Etta J; Vinik, Aaron I; Paulson, James F; Merkies, Ingemar S J; Packman, Jeff; Grogan, Donna R; Coelho, Teresa

    2014-06-01

    The Norfolk Quality of Life-Diabetic Neuropathy (QOL-DN) questionnaire is an instrument to assess QOL in diabetic polyneuropathy. The objective of this observational, cross-sectional study in 61 patients with V30M transthyretin familial amyloid polyneuropathy (TTR-FAP) and 16 healthy volunteers was to validate the Norfolk QOL-DN for assessment of QOL in TTR-FAP. Comparisons were conducted to identify the best items to discriminate disease stages and assess which individual Norfolk domains (symptoms, large fiber, small fiber, autonomic, and activities of daily living) would be most affected by disease stage. Analysis of individual items revealed a significant pattern of discrimination among disease stages (p < 0.001). Total QOL scores increased (indicating worsening) with duration of symptoms, with a steeper increase observed earlier in the course of disease. Significant correlations were observed between each Norfolk domain and other measures of neurological function. Limitations include cross-sectional study design, low patient numbers in this rare disease, and the ordinal-based character of the metric used; future areas to explore include item response theory approaches such as Rasch analysis. These results suggest the Norfolk QOL-DN is a reliable indicator of the impact of disease severity on QOL in patients with TTR-FAP. PMID:24738700

  2. [Dialysis and quality of life: identifying and managing critical aspects].

    PubMed

    Del Corso, C; Caravello, G; Betti, M G; Ferretti, S; Lunardi, W; Tavolaro, A; Capitanini, A; Petrone, I; Rossi, A; Cerri, A; Galati, V; Marini, M; Sardi, T; Valenti, I

    2008-01-01

    Living with a chronic disease is for the patient a ''disease experience'' that also affects the psychosocial sphere and has a negative impact on perceived quality of life. To estimate the effect of dialysis on the perceived quality of life and to identify by means of a specific questionnaire the aspects that are compromised most. From our results it emerged that the examined patients had a sufficiently good total perception of quality of life, even though about 30% of the patients reported critical aspects related to daily life and, in some age groups, also related to dialysis method. This study confirms the importance of developing educational and supportive predialysis programs in order to identify and reduce the critical aspects. PMID:18350501

  3. Identifying sexual differentiation genes that affect Drosophila life span

    PubMed Central

    2009-01-01

    Background Sexual differentiation often has significant effects on life span and aging phenotypes. For example, males and females of several species have different life spans, and genetic and environmental manipulations that affect life span often have different magnitude of effect in males versus females. Moreover, the presence of a differentiated germ-line has been shown to affect life span in several species, including Drosophila and C. elegans. Methods Experiments were conducted to determine how alterations in sexual differentiation gene activity might affect the life span of Drosophila melanogaster. Drosophila females heterozygous for the tudor[1] mutation produce normal offspring, while their homozygous sisters produce offspring that lack a germ line. To identify additional sexual differentiation genes that might affect life span, the conditional transgenic system Geneswitch was employed, whereby feeding adult flies or developing larvae the drug RU486 causes the over-expression of selected UAS-transgenes. Results In this study germ-line ablation caused by the maternal tudor[1] mutation was examined in a long-lived genetic background, and was found to increase life span in males but not in females, consistent with previous reports. Fitting the data to a Gompertz-Makeham model indicated that the maternal tudor[1] mutation increases the life span of male progeny by decreasing age-independent mortality. The Geneswitch system was used to screen through several UAS-type and EP-type P element mutations in genes that regulate sexual differentiation, to determine if additional sex-specific effects on life span would be obtained. Conditional over-expression of transformer female isoform (traF) during development produced male adults with inhibited sexual differentiation, however this caused no significant change in life span. Over-expression of doublesex female isoform (dsxF) during development was lethal to males, and produced a limited number of female escapers

  4. Identifying and relating biological concepts in the Catalogue of Life

    PubMed Central

    2011-01-01

    Background In this paper we describe our experience of adding globally unique identifiers to the Species 2000 and ITIS Catalogue of Life, an on-line index of organisms which is intended, ultimately, to cover all the world's known species. The scientific species names held in the Catalogue are names that already play an extensive role as terms in the organisation of information about living organisms in bioinformatics and other domains, but the effectiveness of their use is hindered by variation in individuals' opinions and understanding of these terms; indeed, in some cases more than one name will have been used to refer to the same organism. This means that it is desirable to be able to give unique labels to each of these differing concepts within the catalogue and to be able to determine which concepts are being used in other systems, in order that they can be associated with the concepts in the catalogue. Not only is this needed, but it is also necessary to know the relationships between alternative concepts that scientists might have employed, as these determine what can be inferred when data associated with related concepts is being processed. A further complication is that the catalogue itself is evolving as scientific opinion changes due to an increasing understanding of life. Results We describe how we are using Life Science Identifiers (LSIDs) as globally unique identifiers in the Catalogue of Life, explaining how the mapping to species concepts is performed, how concepts are associated with specific editions of the catalogue, and how the Taxon Concept Schema has been adopted in order to express information about concepts and their relationships. We explore the implications of using globally unique identifiers in order to refer to abstract concepts such as species, which incorporate at least a measure of subjectivity in their definition, in contrast with the more traditional use of such identifiers to refer to more tangible entities, events, documents

  5. Schema driven assignment and implementation of life science identifiers (LSIDs).

    PubMed

    Bafna, Sapna; Humphries, Julian; Miranker, Daniel P

    2008-10-01

    Life science identifier (LSID) is a global unique identifier standard intended to help rationalize the unique archival requirements of biological data. We describe LSID implementation architecture such that data managed by a relational database management system may be integrated with the LSID protocol as an add-on layer. The approach requires a database administrator (DBA) to specify an export schema detailing the content and structure of the archived data, and a mapping of the existing database to that schema. This specification can be expressed using SQL view syntax. In effect, we define a SQL-like language for implementing LSIDs. We describe the mapping of the view definition to an implementation as a set of databases triggers and a fixed runtime library. Thus a compiler for a domain-specific language could be written that would reduce the implementation of LSIDs to the task of writing SQL view-like definitions. PMID:18599379

  6. Identifying improvement potentials in cement production with life cycle assessment.

    PubMed

    Boesch, Michael Elias; Hellweg, Stefanie

    2010-12-01

    Cement production is an environmentally relevant process responsible for 5% of total anthropogenic carbon dioxide emissions and 7% of industrial fuel use. In this study, life cycle assessment is used to evaluate improvement potentials in the cement production process in Europe and the USA. With a current fuel substitution rate of 18% in Europe and 11% in the USA, both regions have a substantial potential to reduce greenhouse gas emissions and save virgin resources by further increasing the coprocessing of waste fuels. Upgrading production technology would be particularly effective in the USA where many kiln systems with very low energy efficiency are still in operation. Using best available technology and a thermal substitution rate of 50% for fuels, greenhouse gas emissions could be reduced by 9% for Europe and 18% for the USA per tonne of cement. Since clinker production is the dominant pollution producing step in cement production, the substitution of clinker with mineral components such as ground granulated blast furnace slag or fly ash is an efficient measure to reduce the environmental impact. Blended cements exhibit substantially lower environmental footprints than Portland cement, even if the substitutes feature lower grindability and require additional drying and large transport distances. The highest savings in CO(2) emissions and resource consumption are achieved with a combination of measures in clinker production and cement blending. PMID:21047057

  7. Can we identify patients at risk of life-threatening allergic reactions to food?

    PubMed

    Turner, P J; Baumert, J L; Beyer, K; Boyle, R J; Chan, C-H; Clark, A T; Crevel, R W R; DunnGalvin, A; Fernández-Rivas, M; Gowland, M H; Grabenhenrich, L; Hardy, S; Houben, G F; O'B Hourihane, J; Muraro, A; Poulsen, L K; Pyrz, K; Remington, B C; Schnadt, S; van Ree, R; Venter, C; Worm, M; Mills, E N C; Roberts, G; Ballmer-Weber, B K

    2016-09-01

    Anaphylaxis has been defined as a 'severe, life-threatening generalized or systemic hypersensitivity reaction'. However, data indicate that the vast majority of food-triggered anaphylactic reactions are not life-threatening. Nonetheless, severe life-threatening reactions do occur and are unpredictable. We discuss the concepts surrounding perceptions of severe, life-threatening allergic reactions to food by different stakeholders, with particular reference to the inclusion of clinical severity as a factor in allergy and allergen risk management. We review the evidence regarding factors that might be used to identify those at most risk of severe allergic reactions to food, and the consequences of misinformation in this regard. For example, a significant proportion of food-allergic children also have asthma, yet almost none will experience a fatal food-allergic reaction; asthma is not, in itself, a strong predictor for fatal anaphylaxis. The relationship between dose of allergen exposure and symptom severity is unclear. While dose appears to be a risk factor in at least a subgroup of patients, studies report that individuals with prior anaphylaxis do not have a lower eliciting dose than those reporting previous mild reactions. It is therefore important to consider severity and sensitivity as separate factors, as a highly sensitive individual will not necessarily experience severe symptoms during an allergic reaction. We identify the knowledge gaps that need to be addressed to improve our ability to better identify those most at risk of severe food-induced allergic reactions. PMID:27138061

  8. Identifying illness perception schemata and their association with depression and quality of life in cardiac patients.

    PubMed

    Le Grande, Michael R; Elliott, Peter C; Worcester, Marian U C; Murphy, Barbara M; Goble, Alan J; Kugathasan, Vanessa; Sinha, Karan

    2012-01-01

    The purpose of this paper is to identify groups of cardiac patients who share similar perceptions about their illness and to examine the relationships between these schemata and psychosocial outcomes such as quality of life and depression. A total of 190 cardiac patients with diagnoses of myocardial infarction, stable angina pectoris or chronic heart failure, completed a battery of psychosocial questionnaires within four weeks of their admission to hospital. These included the Brief Illness Perceptions Questionnaire (BIPQ), Beck Depression Inventory II (BDI II) and The MacNew Health-related Quality of Life instrument (MacNew). BIPQ items were subjected to latent class analysis (LCA) and the resulting groups were compared according to their BDI II and MacNew scores. LCA identified a five-class model of illness perception which comprised the following: (1) Consequence focused and mild emotional impact, n = 55, 29%; (2) Low illness perceptions and low emotional impact, n = 45, 24%; (3) Control focused and mild emotional impact, n = 10, 5%; (4) Consequence focused and high emotional impact, n = 60, 32%; and (5) Consequence focused and severe emotional impact, n = 20, 10%. Gender and diagnosis did not appear to reflect class membership except that class 2 had a significantly higher proportion of AMI patients than did class 5. There were numerous significant differences between classes in regards to depression and health-related quality of life. Notably, classes 4 and 5 are distinguished by relatively high BDI II scores and low MacNew scores. Identifying classes of cardiac patients based on their illness perception schemata, in hospital or shortly afterwards, may identify those at risk of developing depressive symptoms and poor quality of life. PMID:22416847

  9. Identifying and Classifying Quality of Life Tools for Assessing Spasticity After Spinal Cord Injury

    PubMed Central

    Hitzig, Sander L.; Flett, Heather; Noreau, Luc; Craven, B. Catharine

    2014-01-01

    Objective: To identify and classify tools for assessing the influence of spasticity on quality of life (QOL) after spinal cord injury (SCI). Methods: Electronic databases (MEDLINE/PubMed CINAHL and PsycInfo) were searched for studies published between 1975 and 2012. Dijkers’s theoretical framework on QOL was used to classify tools as either objective or subjective measures of QOL. Results: Sixteen studies met the inclusion criteria. Identified objective measures that were used to assess the influence of spasticity on QOL included the Short Form-36 (SF-36) the Sickness Impact Profile (SIP) and the Health Utilities Index-III (HUI-III). Subjective measures included the Quality of Life Index–SCI Version III (QLI-SCI) Life Situation Questionnaire–Revised (LSQ-R) Reciprocal Support Scale (RSS) Profile of Mood States (POMS) Spinal Cord Injury Spasticity Evaluation Tool (SCI-SET) and the Patient Reported Impact of Spasticity Measure (PRISM). A number of tools proved either to be insensitive to the presence of spasticity (QLI-SCI) or yielded mixed (SF-36) or weak (RSS LSQ-R) results. Tools that were sensitive to spasticity had limited psychometric data for use in the SCI population (HUI-III SIP POMS) although 2 were developed specifically for assessing spasticity on daily life post SCI (SCI-SET PRISM). Conclusions: Two condition-specific subjective measures the SCI-SET and PRISM emerged as the most promising tools for the assessment of spasticity impact on QOL after SCI. Further research should focus on establishing the psychometric properties of these measures for use in the SCI population.Key words: outcome measurement quality of life spasticity spinal cord injury PMID:25484567

  10. Dissecting molecular stress networks: identifying nodes of divergence between life-history phenotypes.

    PubMed

    Schwartz, Tonia S; Bronikowski, Anne M

    2013-02-01

    The complex molecular network that underlies physiological stress response is comprised of nodes (proteins, metabolites, mRNAs, etc.) whose connections span cells, tissues and organs. Variable nodes are points in the network upon which natural selection may act. Thus, identifying variable nodes will reveal how this molecular stress network may evolve among populations in different habitats and how it might impact life-history evolution. Here, we use physiological and genetic assays to test whether laboratory-born juveniles from natural populations of garter snakes (Thamnophis elegans), which have diverged in their life-history phenotypes, vary concomitantly at candidate nodes of the stress response network, (i) under unstressed conditions and (ii) in response to an induced stress. We found that two common measures of stress (plasma corticosterone and liver gene expression of heat shock proteins) increased under stress in both life-history phenotypes. In contrast, the phenotypes diverged at four nodes both under unstressed conditions and in response to stress: circulating levels of reactive oxygen species (superoxide, H(2)O(2)); liver gene expression of GPX1 and erythrocyte DNA damage. Additionally, allele frequencies for SOD2 diverge from neutral markers, suggesting diversifying selection on SOD2 alleles. This study supports the hypothesis that these life-history phenotypes have diverged at the molecular level in how they respond to stress, particularly in nodes regulating oxidative stress. Furthermore, the differences between the life-history phenotypes were more pronounced in females. We discuss the responses to stress in the context of the associated life-history phenotype and the evolutionary pressures thought to be responsible for divergence between the phenotypes. PMID:22988821

  11. Identifying and classifying quality-of-life tools for assessing pressure ulcers after spinal cord injury

    PubMed Central

    Hitzig, Sander L.; Balioussis, Christina; Nussbaum, Ethne; McGillivray, Colleen F.; Catharine Craven, B.; Noreau, Luc

    2013-01-01

    Context Although pressure ulcers may negatively influence quality of life (QoL) post-spinal cord injury (SCI), our understanding of how to assess their impact is confounded by conceptual and measurement issues. To ensure that descriptions of pressure ulcer impact are appropriately characterized, measures should be selected according to the domains that they evaluate and the population and pathologies for which they are designed. Objective To conduct a systematic literature review to identify and classify outcome measures used to assess the impact of pressure ulcers on QoL after SCI. Methods Electronic databases (Medline/PubMed, CINAHL, and PsycInfo) were searched for studies published between 1975 and 2011. Identified outcome measures were classified as being either subjective or objective using a QoL model. Results Fourteen studies were identified. The majority of tools identified in these studies did not have psychometric evidence supporting their use in the SCI population with the exception of two objective measures, the Short-Form 36 and the Craig Handicap Assessment and Reporting Technique, and two subjective measures, the Life Situation Questionnaire-Revised and the Ferrans and Powers Quality of Life Index SCI-Version. Conclusion Many QoL outcome tools showed promise in being sensitive to the presence of pressure ulcers, but few of them have been validated for use with SCI. Prospective studies should employ more rigorous methods for collecting data on pressure ulcer severity and location to improve the quality of findings with regard to their impact on QoL. The Cardiff Wound Impact Schedule is a potential tool for assessing impact of pressure ulcers-post SCI. PMID:24090238

  12. The role of Life Cycle Assessment in identifying and reducing environmental impacts of CCS

    SciTech Connect

    Sathre, Roger; Masanet, Eric; Cain, Jennifer; Chester, Mikhail

    2011-04-20

    Life Cycle Assessment (LCA) should be used to assist carbon capture and sequestration (CCS) planners to reduce greenhouse gas (GHG) emissions and avoid unintended environmental trade-offs. LCA is an analytical framework for determining environmental impacts resulting from processes, products, and services. All life cycle stages are evaluated including raw material sourcing, processing, operation, maintenance, and component end-of-life, as well as intermediate stages such as transportation. In recent years a growing number of LCA studies have analyzed CCS systems. We reviewed 50+ LCA studies, and selected 11 studies that compared the environmental performance of 23 electric power plants with and without CCS. Here we summarize and interpret the findings of these studies. Regarding overall climatemitigation effectiveness of CCS, we distinguish between the capture percentage of carbon in the fuels, the net carbon dioxide (CO2) emission reduction, and the net GHG emission reduction. We also identify trade-offs between the climate benefits and the potential increased non-climate impacts of CCS. Emissions of non-CO2 flue gases such as NOx may increase due to the greater throughput of fuel, and toxicity issues may arise due to the use of monoethanolamine (MEA) capture solvent, resulting in ecological and human health impacts. We discuss areas where improvements in LCA data or methods are needed. The decision to implement CCS should be based on knowledge of the overall environmental impacts of the technologies, not just their carbon capture effectiveness. LCA will be an important tool in providing that knowledge.

  13. A newly identified apothecary in Boswell's Life of Johnson: Edward Ferrand (1691-1769).

    PubMed

    Caudle, James J; Bundock, Michael

    2014-05-01

    Ever since the publication of James Boswell's Life of Samuel Johnson (1791), it has been known that Johnson's young servant, the former slave Francis Barber 'ran away' at one point and worked for a London apothecary. But the apothecary was not named by Boswell and has not been identified by any of Johnson's numerous biographers nor in recent studies of Francis Barber. Research in surviving Boswell manuscripts, 18th-century London guides and the archives of the Society of Apothecaries prove the apothecary to have been Edward Ferrand. This article sets out the circumstances in which the reference to the anonymous apothecary came to appear in the Life of Johnson and reconstructs Ferrand's life and career. Examining Ferrand's origins, his social circumstances and his career, a case study is presented of a successful practitioner of the profession of apothecary in early Georgian Britain and a suggestion made as to why the distinguished apothecary came to provide a place of refuge for a teenaged runaway servant who had been a slave until he was about nine years old. PMID:24585592

  14. Identifying nutritional, functional, and quality of life correlates with male hypogonadism in advanced cancer patients

    PubMed Central

    Fuoco, Domenico; di Tomasso, Jonathan; Boulos, Caroline; Kilgour, Robert D; Morais, Jose A; Borod, Manuel; Vigano, Antonio

    2015-01-01

    With the availability of a potential treatment to reverse male hypogonadism (MH), the primary aim of this case series study was to determine independent relationships between this condition and the nutritional, functional, and quality of life characteristics of advanced cancer patients (ACP). Free testosterone levels were measured in 100 male patients with advanced lung and gastrointestinal (GI) cancer. Routine blood markers of nutrition and inflammation, self-reporting questionnaires for symptom, nutrition, and functional status along with handgrip dynamometry were assessed for all patients at bedside. Almost half of this cohort underwent further assessments (body composition, lower body strength, in depth quality of life and fatigue questionnaires) at the McGill Nutrition and Performance Laboratory (mnupal.mcgill.ca). Multiple regression analyses were performed to identify independent correlations between free testosterone and the above measures. Seventy-six percent of patients were diagnosed with MH. Using multiple linear regression, low free testosterone (31.2 pmol/L) was independently associated with lower albumin (B = –3.8 g/L; 95% confidence interval CI –6.8:–0.8), muscle strength (–11.7 lbs; –20.4: –3.0) and mass in upper limbs (–0.8 kg; –1.4: –0.1), overall performance status (Eastern Cooperative Oncology Group Performance Scale, ECOG PS 0.6; 0.1:1.1), cancer-related fatigue (Brief Fatigue Inventory, BFI 16.7; 2.0: 31.3), and overall quality of life (MQoL total score –1.42; –2.5: –0.3). Thus MH seems to be highly prevalent in ACP, and it is independently associated with important nutritional, functional, and quality of life characteristics in this patient population. PMID:26316882

  15. Identifying changes in the support networks of end-of-life carers using social network analysis.

    PubMed

    Leonard, Rosemary; Horsfall, Debbie; Noonan, Kerrie

    2015-06-01

    End-of-life caring is often associated with reduced social networks for both the dying person and for the carer. However, those adopting a community participation and development approach, see the potential for the expansion and strengthening of networks. This paper uses Knox, Savage and Harvey's definitions of three generations social network analysis to analyse the caring networks of people with a terminal illness who are being cared for at home and identifies changes in these caring networks that occurred over the period of caring. Participatory network mapping of initial and current networks was used in nine focus groups. The analysis used key concepts from social network analysis (size, density, transitivity, betweenness and local clustering) together with qualitative analyses of the group's reflections on the maps. The results showed an increase in the size of the networks and that ties between the original members of the network strengthened. The qualitative data revealed the importance between core and peripheral network members and the diverse contributions of the network members. The research supports the value of third generation social network analysis and the potential for end-of-life caring to build social capital. PMID:24644162

  16. Learning impairments identified early in life are predictive of future impairments associated with aging

    PubMed Central

    Hullinger, Rikki; Burger, Corinna

    2016-01-01

    The Morris water maze (MWM) behavioral paradigm is commonly used to measure spatial learning and memory in rodents. It is widely accepted that performance in the MWM declines with age. However, young rats ubiquitously perform very well on established versions of the water maze, suggesting that more challenging tasks may be required to reveal subtle differences in young animals. Therefore, we have used a one-day water maze and novel object recognition to test whether more sensitive paradigms of memory in young animals could identify subtle cognitive impairments early in life that might become accentuated later with senescence. We have found that these two tasks reliably separate young rats into inferior and superior learners, are highly correlated, and that performance on these tasks early in life is predictive of performance at 12 months of age. Furthermore, we have found that repeated training in this task selectively improves the performance of inferior learners, suggesting that behavioral training from an early age may provide a buffer against age-related cognitive decline. PMID:26283528

  17. A Study to Identify the Training Needs of Life Insurance Sales Representatives in Taiwan Using the Delphi Approach

    ERIC Educational Resources Information Center

    Fan, Chiang Ku; Cheng, Chen-Liang

    2006-01-01

    This article reports a study conducted to identify the needs for continuing professional development for life insurance sales representatives and to examine the competencies needed by those sales representatives. A modified Delphi technique was used. Most life insurance companies in the USA implement an education and training plan advocated by the…

  18. Epidemiology of Diabetic Foot Ulcers and Amputations in Romania: Results of a Cross-Sectional Quality of Life Questionnaire Based Survey

    PubMed Central

    Bondor, Cosmina I.; Veresiu, Ioan A.; Florea, Bogdan; Vinik, Etta J.; Vinik, Aaron I.; Gavan, Norina A.

    2016-01-01

    This is a post hoc analysis of quality of life in diabetic neuropathy patients in a cross-sectional survey performed in 2012 in Romania, using the Norfolk QOL-DN in which 21,756 patients with self-reported diabetes were enrolled. This current analysis aims to expand research on the diabetic foot and to provide an update on the number of foot ulcers found in Romania. Of the 21,174 patients included in this analysis, 14.85% reported a history of foot ulcers and 3.60% reported an amputation. The percentage of neuropathy patients with foot ulcers increased with age; the lowest percentage was observed in the 20–29-year age group (6.62%) and the highest in the 80–89-year age group (17.68%). The highest number of amputations was reported in the 70–79-year age group (largest group). Compared to patients without foot ulcers, those with foot ulcers had significantly higher scores for total DN and all its subdomains translating to worse QOL (p < 0.001). This analysis showed a high rate of foot ulcers and amputations in Romanian diabetic patients. It underscores the need for implementation of effective screening and educational programs. PMID:27019852

  19. Identifying Inviolable Behavioral Norms of Campus Housing and Residence Life Professionals

    ERIC Educational Resources Information Center

    Hirschy, Amy S.; Wilson, Maureen E.; Braxton, John M.

    2015-01-01

    Housing and residence life (HRL) administrators who lack knowledge about accepted professional behaviors risk violating normative boundaries, likely jeopardizing themselves or their clients (e.g., students, parents, colleagues). The purpose of this survey study was to understand if a normative structure exists for the administrative role…

  20. Identifying Opportunities for Improving the Quality of Life of Older Age Groups.

    ERIC Educational Resources Information Center

    Flanagan, John C.

    The situations and feelings of representative national samples of 50- and 70-year-olds were investigated in order to provide a representative, adequate data base for planning programs and policies that will result in maximum improvement in the quality of life of older Americans at minimum costs to taxpayers. Intensive case studies of 1,000…

  1. Cumulative experiences with life adversity: Identifying critical levels for targeting prevention efforts

    PubMed Central

    Mitchell, Kimberly J.; Tynes, Brendesha; Umaña-Taylor, Adriana J.; Williams, David

    2015-01-01

    This paper aims to assess the role of individual types and cumulative life adversity for understanding depressive symptomatology and aggressive behavior. Data were collected in 2011 as part of the Teen Life Online and in Schools Study from 916 ethnically-diverse students from 12 middle, K-8, 6-12 and high schools in the Midwest United States. Youth reported an average of 4.1 non-victimization adversities and chronic stressors in their lifetimes. There was a linear relationship between number of adversities and depression and aggression scores. Youth reporting the highest number of adversities (7 or more) had significantly higher depression and aggression scores than youth reporting any other number of adversities suggesting exposure at this level is a critical tipping point for mental health concerns. Findings underscore an urgent need to support youth as they attempt to negotiate, manage, and cope with adversity in their social worlds. PMID:26057876

  2. Cumulative experiences with life adversity: Identifying critical levels for targeting prevention efforts.

    PubMed

    Mitchell, Kimberly J; Tynes, Brendesha; Umaña-Taylor, Adriana J; Williams, David

    2015-08-01

    This paper aims to assess the role of individual types and cumulative life adversity for understanding depressive symptomatology and aggressive behavior. Data were collected in 2011 as part of the Teen Life Online and in Schools Study from 916 ethnically-diverse students from 12 middle, K-8, 6-12 and high schools in the Midwest United States. Youth reported an average of 4.1 non-victimization adversities and chronic stressors in their lifetimes. There was a linear relationship between number of adversities and depression and aggression scores. Youth reporting the highest number of adversities (7 or more) had significantly higher depression and aggression scores than youth reporting any other number of adversities suggesting exposure at this level is a critical tipping point for mental health concerns. Findings underscore an urgent need to support youth as they attempt to negotiate, manage, and cope with adversity in their social worlds. PMID:26057876

  3. Newly identified and diverse plastid-bearing branch on the eukaryotic tree of life.

    PubMed

    Kim, Eunsoo; Harrison, James W; Sudek, Sebastian; Jones, Meredith D M; Wilcox, Heather M; Richards, Thomas A; Worden, Alexandra Z; Archibald, John M

    2011-01-25

    The use of molecular methods is altering our understanding of the microbial biosphere and the complexity of the tree of life. Here, we report a newly discovered uncultured plastid-bearing eukaryotic lineage named the rappemonads. Phylogenies using near-complete plastid ribosomal DNA (rDNA) operons demonstrate that this group represents an evolutionarily distinct lineage branching with haptophyte and cryptophyte algae. Environmental DNA sequencing revealed extensive diversity at North Atlantic, North Pacific, and European freshwater sites, suggesting a broad ecophysiology and wide habitat distribution. Quantitative PCR analyses demonstrate that the rappemonads are often rare but can form transient blooms in the Sargasso Sea, where high 16S rRNA gene copies mL(-1) were detected in late winter. This pattern is consistent with these microbes being a member of the rare biosphere, whose constituents have been proposed to play important roles under ecosystem change. Fluorescence in situ hybridization revealed that cells from this unique lineage were 6.6 ± 1.2 × 5.7 ± 1.0 μm, larger than numerically dominant open-ocean phytoplankton, and appear to contain two to four plastids. The rappemonads are unique, widespread, putatively photosynthetic algae that are absent from present-day ecosystem models and current versions of the tree of life. PMID:21205890

  4. Latent class analysis identifies three subtypes of aggressive end-of-life care: a population-based study in Taiwan.

    PubMed

    Chen, Mei-Ling; Chen, Yun-Yi; Tang, Siew Tzuh

    2013-10-01

    The aggressiveness of end-of-life (EOL) cancer care has often been analysed by the occurrence of several indicators, separately or aggregately. Whether aggressive EOL cancer care has different subtypes is unknown. This study sought to identify distinct subtypes of aggressive EOL care based on usage patterns of aggressive EOL-care indicators and to explore demographic, disease and treatment factors associated with the identified subtypes. This retrospective study linked data from 2001 to 2006 from three Taiwanese databases: National Registration of Death Database, Cancer Registration System and National Health Insurance claims database. Adult cancer patients (N=203,642) who died in 2001-2006 were selected. For these cancer patients' last month of life, we analysed eight indicators of aggressive EOL care: receiving chemotherapy, >1 emergency room visit, >1 hospitalisation, hospitalisation for >14 days, intensive care unit admission, received cardiopulmonary resuscitation, received intubation and received mechanical ventilation. Subtypes of aggressive EOL care were identified by latent class analysis. Among the study population, only 22.3% were treated by medical oncologists. Based on their profiles of EOL care, deceased cancer patients were classified into three subgroups: 'not aggressive' (45%), 'intent to sustain life' (33%) and 'symptom crisis' group (22%). Patients assigned to the 'intent to sustain life' group were less likely to have metastatic disease and to receive hospice care in the last year of life, but more likely to be cared for by non-medical oncologists, to die within 2 months after diagnosis and to die in hospital. EOL cancer care may be improved by understanding factors related to different subtypes of aggressive EOL care. PMID:23756054

  5. Mackinawite and greigite in ancient alkaline hydrothermal chimneys: Identifying potential key catalysts for emergent life

    NASA Astrophysics Data System (ADS)

    White, Lauren M.; Bhartia, Rohit; Stucky, Galen D.; Kanik, Isik; Russell, Michael J.

    2015-11-01

    One model for the emergence of life posits that ancient, low temperature, submarine alkaline hydrothermal vents, partly composed of iron-sulfides, were capable of catalyzing the synthesis of prebiotic organic molecules from CO2, H2 and CH4. Specifically, hydrothermal mackinawite (FeIIS) and greigite (FeIIFeIII2S4) have been highlighted in previous studies as analogs of the active centers of hydrogenase, ferredoxin, acetyl coenzyme-A synthase and carbon monoxide dehydrogenase featured in the biochemistry of certain autotrophic prokaryotes that occupy the base of the evolutionary tree. Despite the proposed importance of iron sulfide minerals and clusters in the synthesis of abiotic organic molecules, the mechanisms for the formation of these sulfides from solution and their preservation under the anoxic and low temperature (below 100 °C) conditions expected in off-axis submarine alkaline vent systems is not well understood (Bourdoiseau et al., 2011; Rickard and Luther, 2007). To rectify this, single hydrothermal chimneys were precipitated using a unique apparatus to simulate growth at hydrothermal vents of moderate temperature under supposed Hadean ocean-bottom conditions. Iron sulfide phases were observed through Raman spectroscopy at growth temperatures ranging from 40° to 80 °C. Fe(III)-containing mackinawite is confirmed to be present with mackinawite and greigite, supporting an FeIII-mackinawite intermediate mechanism for the transformation of mackinawite to greigite below 100 °C. Raman spectroscopy of the chimneys revealed a maximum yield of greigite at 75 °C. These results suggest abiotic production of catalytically active mackinawite and greigite are possible under early Earth hydrothermal conditions as well as on other wet, rocky worlds geochemically similar to the Earth.

  6. Data mining approach identifies research priorities and data requirements for resolving the red algal tree of life

    PubMed Central

    2010-01-01

    Background The assembly of the tree of life has seen significant progress in recent years but algae and protists have been largely overlooked in this effort. Many groups of algae and protists have ancient roots and it is unclear how much data will be required to resolve their phylogenetic relationships for incorporation in the tree of life. The red algae, a group of primary photosynthetic eukaryotes of more than a billion years old, provide the earliest fossil evidence for eukaryotic multicellularity and sexual reproduction. Despite this evolutionary significance, their phylogenetic relationships are understudied. This study aims to infer a comprehensive red algal tree of life at the family level from a supermatrix containing data mined from GenBank. We aim to locate remaining regions of low support in the topology, evaluate their causes and estimate the amount of data required to resolve them. Results Phylogenetic analysis of a supermatrix of 14 loci and 98 red algal families yielded the most complete red algal tree of life to date. Visualization of statistical support showed the presence of five poorly supported regions. Causes for low support were identified with statistics about the age of the region, data availability and node density, showing that poor support has different origins in different parts of the tree. Parametric simulation experiments yielded optimistic estimates of how much data will be needed to resolve the poorly supported regions (ca. 103 to ca. 104 nucleotides for the different regions). Nonparametric simulations gave a markedly more pessimistic image, some regions requiring more than 2.8 105 nucleotides or not achieving the desired level of support at all. The discrepancies between parametric and nonparametric simulations are discussed in light of our dataset and known attributes of both approaches. Conclusions Our study takes the red algae one step closer to meaningful inclusion in the tree of life. In addition to the recovery of stable

  7. In silico repositioning-chemogenomics strategy identifies new drugs with potential activity against multiple life stages of Schistosoma mansoni.

    PubMed

    Neves, Bruno J; Braga, Rodolpho C; Bezerra, José C B; Cravo, Pedro V L; Andrade, Carolina H

    2015-01-01

    Morbidity and mortality caused by schistosomiasis are serious public health problems in developing countries. Because praziquantel is the only drug in therapeutic use, the risk of drug resistance is a concern. In the search for new schistosomicidal drugs, we performed a target-based chemogenomics screen of a dataset of 2,114 proteins to identify drugs that are approved for clinical use in humans that may be active against multiple life stages of Schistosoma mansoni. Each of these proteins was treated as a potential drug target, and its amino acid sequence was used to interrogate three databases: Therapeutic Target Database (TTD), DrugBank and STITCH. Predicted drug-target interactions were refined using a combination of approaches, including pairwise alignment, conservation state of functional regions and chemical space analysis. To validate our strategy, several drugs previously shown to be active against Schistosoma species were correctly predicted, such as clonazepam, auranofin, nifedipine, and artesunate. We were also able to identify 115 drugs that have not yet been experimentally tested against schistosomes and that require further assessment. Some examples are aprindine, gentamicin, clotrimazole, tetrabenazine, griseofulvin, and cinnarizine. In conclusion, we have developed a systematic and focused computer-aided approach to propose approved drugs that may warrant testing and/or serve as lead compounds for the design of new drugs against schistosomes. PMID:25569258

  8. In Silico Repositioning-Chemogenomics Strategy Identifies New Drugs with Potential Activity against Multiple Life Stages of Schistosoma mansoni

    PubMed Central

    Neves, Bruno J.; Braga, Rodolpho C.; Bezerra, José C. B.; Cravo, Pedro V. L.; Andrade, Carolina H.

    2015-01-01

    Morbidity and mortality caused by schistosomiasis are serious public health problems in developing countries. Because praziquantel is the only drug in therapeutic use, the risk of drug resistance is a concern. In the search for new schistosomicidal drugs, we performed a target-based chemogenomics screen of a dataset of 2,114 proteins to identify drugs that are approved for clinical use in humans that may be active against multiple life stages of Schistosoma mansoni. Each of these proteins was treated as a potential drug target, and its amino acid sequence was used to interrogate three databases: Therapeutic Target Database (TTD), DrugBank and STITCH. Predicted drug-target interactions were refined using a combination of approaches, including pairwise alignment, conservation state of functional regions and chemical space analysis. To validate our strategy, several drugs previously shown to be active against Schistosoma species were correctly predicted, such as clonazepam, auranofin, nifedipine, and artesunate. We were also able to identify 115 drugs that have not yet been experimentally tested against schistosomes and that require further assessment. Some examples are aprindine, gentamicin, clotrimazole, tetrabenazine, griseofulvin, and cinnarizine. In conclusion, we have developed a systematic and focused computer-aided approach to propose approved drugs that may warrant testing and/or serve as lead compounds for the design of new drugs against schistosomes. PMID:25569258

  9. Identifying key domains of health-related quality of life for patients with Chronic Obstructive Pulmonary Disease: the patient perspective

    PubMed Central

    2014-01-01

    Background Numerous instruments are available to measure health-related quality of life (HRQoL) in patients with Chronic Obstructive Pulmonary Disease (COPD), covering a wide array of domains ranging from symptoms such as dyspnea, cough and wheezing, to social and emotional functioning. Currently no information or guide is available yet to aid the selection of domains for a particular study or disease population. The aim of this paper is to identify which domains of HRQoL are most important with respect to COPD, from the patient perspective. Methods Twenty-one Dutch patients with COPD were asked to describe important domains impacted by COPD freely; second, they were presented with cues (domains from the Patient-Reported Outcomes Measurement Information System (PROMIS) framework) and were asked to select the domains that were most relevant to them. During the interview, the patients were asked to indicate in which way the selected domains impact their lives. Both the answers to the open question, and the patient statements motivating nomination of PROMIS domains were coded into themes. Results The most relevant (sub)domains of HRQoL for patients with COPD were: physical health (fatigue, physical functioning), social health (instrumental support, ability to participate in social roles and activities, companionship, and emotional support), and coping with COPD. Conclusion We identified which domains of HRQoL are most important to patients with COPD. One of these (coping with COPD) is not explicitly covered by PROMIS, or by traditional questionnaires that are used to measure HRQoL in COPD. PMID:25005552

  10. Health-related quality of life among veterans in addictions treatment: identifying behavioral targets for future intervention

    PubMed Central

    Oppezzo, Marily A.; Michalek, Anne K.; Delucchi, Kevin; Baiocchi, Michael T. M.; Barnett, Paul G.

    2016-01-01

    Background US veterans report lower health-related quality of life (HRQoL) relative to the general population. Identifying behavioral factors related to HRQoL that are malleable to change may inform interventions to improve well-being in this vulnerable group. Purpose The current study sought to characterize HRQoL in a largely male sample of veterans in addictions treatment, both in relation to US norms and in association with five recommended health behavior practices: regularly exercising, managing stress, having good sleep hygiene, consuming fruits and vegetables, and being tobacco free. Methods We assessed HRQoL with 250 veterans in addictions treatment (96 % male, mean age 53, range 24–77) using scales from four validated measures. Data reduction methods identified two principal components reflecting physical and mental HRQoL. Model testing of HRQoL associations with health behaviors adjusted for relevant demographic and treatment-related covariates. Results Compared to US norms, the sample had lower HRQoL scores. Better psychological HRQoL was associated with higher subjective social standing, absence of pain or trauma, lower alcohol severity, and monotonically with the sum of health behaviors (all p < 0.05). Specifically, psychological HRQoL was associated with regular exercise, stress management, and sleep hygiene. Regular exercise also related to better physical HRQoL. The models explained >40 % of the variance in HRQoL. Conclusions Exercise, sleep hygiene, and stress management are strongly associated with HRQoL among veterans in addictions treatment. Future research is needed to test the effect of interventions for improving well-being in this high-risk group. PMID:26886926

  11. The life-cycle of upper-tropospheric jet streams identified with a novel data segmentation algorithm

    NASA Astrophysics Data System (ADS)

    Limbach, S.; Schömer, E.; Wernli, H.

    2010-09-01

    -tropospheric jet streams, their preferred regions of genesis, merging, splitting, and lysis, and statistical information about their size, amplitude and lifetime. The presentation will introduce the technique, provide example visualizations of the time evolution of the identified 3-dimensional jet stream features, and present results from a first multi-month "climatology" of upper-tropospheric jets. In the future, the technique can be applied to longer datasets, for instance reanalyses and output from global climate model simulations - and provide detailed information about key characteristics of jet stream life cycles.

  12. Exploration of very high spatial resolution data for vegetation mapping using cartographic ontologies: Identifying life forms to mapping formations

    NASA Astrophysics Data System (ADS)

    Rodriguez-Gallegos, Hugo Benigno

    Vegetation mapping is often considered the process of identifying landscape patterns of individuals or clusters of species or life forms (LF). At the landscape scale, the larger pattern represented by individuals or clusters represents the conceptualization of "vegetation mapping" and can be used as a building block to describe an ecosystem. To represent these building blocks or LF a "common entity (CE)" concept is introduced to represent the components of Formations as described by the National Vegetation Classification (NVC) system. The NVC has established protocols to consistently represent plant communities and promote coordinated management, particularly across jurisdictional boundaries. However, it is not a universal standard and the methods of producing detailed maps of vegetation CE from very high spatial resolution (VHR) remote sensing data are important research questions. This research addressed how best to understand and represent plant cover in arid regions, the most effective methods of mapping vegetation cover using high spatial resolution data, how to assess the accuracy of these maps, and their value in establishing more standardized mapping protocols across ecosystems. Utilizing VHR products from the IKONOS and QuickBird sensors the study focused on the Coronado National Memorial and Chiricahua National Monument in Arizona and Los Ajos and Pinacate - Grand Desierto Biosphere Reserves in Mexico. Individual CE were semi-automatically mapped incorporating spectral, textural and geostatistical variables. The results were evaluated across sensors, study sites, and input variables. In addition, multiple methods of acquiring field data for accuracy assessment were evaluated and then an evaluation was made of a semi-automatic determination of Formation based on CE. The results of the study suggest consistency across study sites using the IKONOS data. A comparison between VHR products from the same place is feasible but sensor spectral differences may

  13. A Phylogenomic Census of Molecular Functions Identifies Modern Thermophilic Archaea as the Most Ancient Form of Cellular Life

    PubMed Central

    Kim, Kyung Mo; Caetano-Anollés, Gustavo

    2014-01-01

    The origins of diversified life remain mysterious despite considerable efforts devoted to untangling the roots of the universal tree of life. Here we reconstructed phylogenies that described the evolution of molecular functions and the evolution of species directly from a genomic census of gene ontology (GO) definitions. We sampled 249 free-living genomes spanning organisms in the three superkingdoms of life, Archaea, Bacteria, and Eukarya, and used the abundance of GO terms as molecular characters to produce rooted phylogenetic trees. Results revealed an early thermophilic origin of Archaea that was followed by genome reduction events in microbial superkingdoms. Eukaryal genomes displayed extraordinary functional diversity and were enriched with hundreds of novel molecular activities not detected in the akaryotic microbial cells. Remarkably, the majority of these novel functions appeared quite late in evolution, synchronized with the diversification of the eukaryal superkingdom. The distribution of GO terms in superkingdoms confirms that Archaea appears to be the simplest and most ancient form of cellular life, while Eukarya is the most diverse and recent. PMID:25249790

  14. Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation

    PubMed Central

    Shamalnasab, Mehrnaz; Galbani, Abdulaye; Wei, Min; Giaever, Guri; Nislow, Corey; Longo, Valter D.

    2010-01-01

    The study of the chronological life span of Saccharomyces cerevisiae, which measures the survival of populations of non-dividing yeast, has resulted in the identification of homologous genes and pathways that promote aging in organisms ranging from yeast to mammals. Using a competitive genome-wide approach, we performed a screen of a complete set of approximately 4,800 viable deletion mutants to identify genes that either increase or decrease chronological life span. Half of the putative short-/long-lived mutants retested from the primary screen were confirmed, demonstrating the utility of our approach. Deletion of genes involved in vacuolar protein sorting, autophagy, and mitochondrial function shortened life span, confirming that respiration and degradation processes are essential for long-term survival. Among the genes whose deletion significantly extended life span are ACB1, CKA2, and TRM9, implicated in fatty acid transport and biosynthesis, cell signaling, and tRNA methylation, respectively. Deletion of these genes conferred heat-shock resistance, supporting the link between life span extension and cellular protection observed in several model organisms. The high degree of conservation of these novel yeast longevity determinants in other species raises the possibility that their role in senescence might be conserved. PMID:20657825

  15. Using peel fluorescence in black light rooms to identify navel oranges with shorter storage life and poor rind quality

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The objective of this project is to minimize postharvest decay losses of fresh citrus fruits. Among the approaches recently examined was peel fluorescence under ultraviolet light. In addition to its usual application to identify fruit with developing decay lesions (“blister” or “clear” rot) in black...

  16. Identifying structural elements needed for development of a predictive life-history model for pallid and shovelnose sturgeons

    USGS Publications Warehouse

    Wildhaber, Mark L.; DeLonay, A.J.; Papoulias, D.M.; Galat, D.L.; Jacobson, R.B.; Simpkins, D.G.; Braaten, P.J.; Korschgen, C.E.; Mac, M.J.

    2011-01-01

    Intensive management of the Missouri and Mississippi Rivers has resulted in dramatic changes to the river systems and their biota. These changes have been implicated in the decline of the pallid sturgeon (Scaphirhynchus albus), which has been listed as a United States federal endangered species. The sympatric shovelnose sturgeon (S. platorynchus) is more common and widespread but has also been in decline. The decline of pallid sturgeon is considered symptomatic of poor reproductive success and low or no recruitment. In order to organize information about these species and provide a basis for future development of a predictive model to help guide recovery efforts, we present an expert-vetted, conceptual life-history framework that incorporates the factors that affect reproduction, growth, and survival of shovelnose and pallid sturgeons.

  17. Systems-Based Analysis of the Sarcocystis neurona Genome Identifies Pathways That Contribute to a Heteroxenous Life Cycle

    PubMed Central

    Blazejewski, Tomasz; Nursimulu, Nirvana; Pszenny, Viviana; Dangoudoubiyam, Sriveny; Namasivayam, Sivaranjani; Chiasson, Melissa A.; Chessman, Kyle; Tonkin, Michelle; Swapna, Lakshmipuram S.; Hung, Stacy S.; Bridgers, Joshua; Ricklefs, Stacy M.; Boulanger, Martin J.; Dubey, Jitender P.; Porcella, Stephen F.; Kissinger, Jessica C.; Howe, Daniel K.

    2015-01-01

    ABSTRACT Sarcocystis neurona is a member of the coccidia, a clade of single-celled parasites of medical and veterinary importance including Eimeria, Sarcocystis, Neospora, and Toxoplasma. Unlike Eimeria, a single-host enteric pathogen, Sarcocystis, Neospora, and Toxoplasma are two-host parasites that infect and produce infectious tissue cysts in a wide range of intermediate hosts. As a genus, Sarcocystis is one of the most successful protozoan parasites; all vertebrates, including birds, reptiles, fish, and mammals are hosts to at least one Sarcocystis species. Here we sequenced Sarcocystis neurona, the causal agent of fatal equine protozoal myeloencephalitis. The S. neurona genome is 127 Mbp, more than twice the size of other sequenced coccidian genomes. Comparative analyses identified conservation of the invasion machinery among the coccidia. However, many dense-granule and rhoptry kinase genes, responsible for altering host effector pathways in Toxoplasma and Neospora, are absent from S. neurona. Further, S. neurona has a divergent repertoire of SRS proteins, previously implicated in tissue cyst formation in Toxoplasma. Systems-based analyses identified a series of metabolic innovations, including the ability to exploit alternative sources of energy. Finally, we present an S. neurona model detailing conserved molecular innovations that promote the transition from a purely enteric lifestyle (Eimeria) to a heteroxenous parasite capable of infecting a wide range of intermediate hosts. PMID:25670772

  18. The End-of-Life Experience in Long-Term Care: Five Themes Identified from Focus Groups with Residents, Family Members, and Staff

    ERIC Educational Resources Information Center

    Munn, Jean C.; Dobbs, Debra; Meier, Andrea; Williams, Christianna S.; Biola, Holly; Zimmerman, Sheryl

    2008-01-01

    Purpose: We designed this study to examine the end-of-life (EOL) experience in long-term care (LTC) based on input from key stakeholders. Design and Methods: The study consisted of 10 homogeneous focus groups drawn from a purposive sample of LTC residents (2 groups; total n = 11), family caregivers (2 groups; total n = 19), paraprofessional staff…

  19. Dying in the hospital setting: A systematic review of quantitative studies identifying the elements of end-of-life care that patients and their families rank as being most important

    PubMed Central

    Virdun, Claudia; Luckett, Tim; Davidson, Patricia M; Phillips, Jane

    2015-01-01

    Background: The majority of expected deaths occur in hospitals where optimal end-of-life care is not yet fully realised, as evidenced by recent reviews outlining experience of care. Better understanding what patients and their families consider to be the most important elements of inpatient end-of-life care is crucial to addressing this gap. Aim and design: This systematic review aimed to ascertain the five most important elements of inpatient end-of-life care as identified by patients with palliative care needs and their families. Data sources: Nine electronic databases from 1990 to 2014 were searched along with key internet search engines and handsearching of included article reference lists. Quality of included studies was appraised by two researchers. Results: Of 1859 articles, 8 met the inclusion criteria generating data from 1141 patients and 3117 families. Synthesis of the top five elements identified four common end-of-life care domains considered important to both patients and their families, namely, (1) effective communication and shared decision making, (2) expert care, (3) respectful and compassionate care and (4) trust and confidence in clinicians. The final domains differed with financial affairs being important to families, while an adequate environment for care and minimising burden both being important to patients. Conclusion: This review adds to what has been known for over two decades in relation to patient and family priorities for end-of-life care within the hospital setting. The challenge for health care services is to act on this evidence, reconfigure care systems accordingly and ensure universal access to optimal end-of-life care within hospitals. PMID:25921707

  20. Genome-wide association mapping in a wild avian population identifies a link between genetic and phenotypic variation in a life-history trait

    PubMed Central

    Husby, Arild; Kawakami, Takeshi; Rönnegård, Lars; Smeds, Linnéa; Ellegren, Hans; Qvarnström, Anna

    2015-01-01

    Understanding the genetic basis of traits involved in adaptation is a major challenge in evolutionary biology but remains poorly understood. Here, we use genome-wide association mapping using a custom 50 k single nucleotide polymorphism (SNP) array in a natural population of collared flycatchers to examine the genetic basis of clutch size, an important life-history trait in many animal species. We found evidence for an association on chromosome 18 where one SNP significant at the genome-wide level explained 3.9% of the phenotypic variance. We also detected two suggestive quantitative trait loci (QTLs) on chromosomes 9 and 26. Fitness differences among genotypes were generally weak and not significant, although there was some indication of a sex-by-genotype interaction for lifetime reproductive success at the suggestive QTL on chromosome 26. This implies that sexual antagonism may play a role in maintaining genetic variation at this QTL. Our findings provide candidate regions for a classic avian life-history trait that will be useful for future studies examining the molecular and cellular function of, as well as evolutionary mechanisms operating at, these loci. PMID:25833857

  1. Patient survey to identify reasons for non-adherence and elicitation of quality of life concepts associated with immunosuppressant therapy in kidney transplant recipients

    PubMed Central

    Muduma, Gorden; Shupo, Francis C; Dam, Sophie; Hawken, Natalia A; Aballéa, Samuel; Odeyemi, Isaac; Toumi, Mondher

    2016-01-01

    Background Renal transplantation (RT) is considered the treatment of choice for end-stage renal disease compared to dialysis, offering better health-related quality of life (HRQoL) and higher survival rates. However, immunosuppressants are essential for the long-term survival of kidney grafts and patients’ non-adherence to their medication leads to poor outcomes. Immunosuppressants can also significantly alter patients’ HRQoL because of their side effects and the complex chronic medication regimen they represent. Purpose To elicit key concepts related to adherence to immunosuppressant therapy (IT) and reasons for non-adherence in terms of patient reported outcomes, side effects, and the impact of the medication on HRQoL in RT population, including patient preference of once daily over twice-daily immunosuppressive regimen. Results were used to develop an IT-specific conceptual framework and provide suggestions for improving patients’ adherence to IT. Materials and methods Interviews were conducted with three clinical experts to determine key concepts related to RT and immunosuppressants. Thirty-seven participants in four focus groups were asked to cite important concepts related to adherence and impact of IT on HRQoL and to rate them. Qualitative analysis was conducted to code participants’ responses. Results Non-adherence among participants where admitted was unintentional. The reason for this included forgetfulness, interference with lifestyle, being asleep at the time the medication should be taken, change in routine, and impact of side effects. Overall, participants reported that the evening dose was more problematic to remember and that the exclusion of this dose could make them more adherent. Participants also reported that IT impacted on their HRQoL in a number of ways including: placing restrictions on their lifestyle, causing anxiety, or impairing their ability to work. Conclusion This study provides qualitative evidence about the barriers to IT

  2. Combined Transcriptomic and Proteomic Approach to Identify Toxicity Pathways in Early Life Stages of Japanese Medaka (Oryzias latipes) Exposed to 1,2,5,6-Tetrabromocyclooctane (TBCO).

    PubMed

    Sun, Jianxian; Tang, Song; Peng, Hui; Saunders, David M V; Doering, Jon A; Hecker, Markus; Jones, Paul D; Giesy, John P; Wiseman, Steve

    2016-07-19

    Currently, the novel brominated flame retardant 1,2,5,6-tetrabromocyclooctane (TBCO) is considered a potential replacement for hexabromocyclododecane (HBCD). Therefore, use of TBCO could increase in the near future. To assess potential toxicological risks to aquatic organisms, embryos of Japanese medaka (Oryzias latipes) were exposed to 10, 100, or 1000 μg/L TBCO from 2 h postfertilization until 1 day post-hatch. TBCO accumulated in embryos in the order of 0.43-1.3 × 10(4)-fold, and the rate constant of accumulation was 1.7-1.8 per day. The number of days to hatch and the hatching success of embryos exposed to the medium and the greatest concentrations of TBCO were impaired. Responses of the transcriptome (RNA-seq) and proteome were characterized in embryos exposed to 100 μg/L TBCO because this was the least concentration of TBCO that caused an effect on hatching. Consistent with effects on hatching, proteins whose abundances were reduced by exposure to TBCO were enriched in embryo development and hatching pathways. Also, on the basis of the responses of transcriptome and proteome, it was predicted that TBCO might impair vision and contraction of cardiac muscle, respectively, and these effects were confirmed by targeted bioassays. This study provided a comprehensive understanding of effects of TBCO on medaka at early life stages and illustrated the power of "omics" to explain and predict phenotypic responses to chemicals. PMID:27322799

  3. SPARQL-enabled identifier conversion with Identifiers.org

    PubMed Central

    Wimalaratne, Sarala M.; Bolleman, Jerven; Juty, Nick; Katayama, Toshiaki; Dumontier, Michel; Redaschi, Nicole; Le Novère, Nicolas; Hermjakob, Henning; Laibe, Camille

    2015-01-01

    Motivation: On the semantic web, in life sciences in particular, data is often distributed via multiple resources. Each of these sources is likely to use their own International Resource Identifier for conceptually the same resource or database record. The lack of correspondence between identifiers introduces a barrier when executing federated SPARQL queries across life science data. Results: We introduce a novel SPARQL-based service to enable on-the-fly integration of life science data. This service uses the identifier patterns defined in the Identifiers.org Registry to generate a plurality of identifier variants, which can then be used to match source identifiers with target identifiers. We demonstrate the utility of this identifier integration approach by answering queries across major producers of life science Linked Data. Availability and implementation: The SPARQL-based identifier conversion service is available without restriction at http://identifiers.org/services/sparql. Contact: sarala@ebi.ac.uk PMID:25638809

  4. Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes

    PubMed Central

    Goldberg, Alexander A.; Richard, Vincent R.; Kyryakov, Pavlo; Bourque, Simon D.; Beach, Adam; Burstein, Michelle T.; Glebov, Anastasia; Koupaki, Olivia; Boukh-Viner, Tatiana; Gregg, Christopher; Juneau, Mylène; English, Ann M.; Thomas, David Y.; Titorenko, Vladimir I.

    2010-01-01

    In chronologically aging yeast, longevity can be extended by administering a caloric restriction (CR) diet or some small molecules. These life-extending interventions target the adaptable target of rapamycin (TOR) and cAMP/protein kinase A (cAMP/PKA) signaling pathways that are under the stringent control of calorie availability. We designed a chemical genetic screen for small molecules that increase the chronological life span of yeast under CR by targeting lipid metabolism and modulating housekeeping longevity pathways that regulate longevity irrespective of the number of available calories. Our screen identifies lithocholic acid (LCA) as one of such molecules. We reveal two mechanisms underlying the life-extending effect of LCA in chronologically aging yeast. One mechanism operates in a calorie availability-independent fashion and involves the LCA-governed modulation of housekeeping longevity assurance pathways that do not overlap with the adaptable TOR and cAMP/PKA pathways. The other mechanism extends yeast longevity under non-CR conditions and consists in LCA-driven unmasking of the previously unknown anti-aging potential of PKA. We provide evidence that LCA modulates housekeeping longevity assurance pathways by suppressing lipid-induced necrosis, attenuating mitochondrial fragmentation, altering oxidation-reduction processes in mitochondria, enhancing resistance to oxidative and thermal stresses, suppressing mitochondria-controlled apoptosis, and enhancing stability of nuclear and mitochondrial DNA. PMID:20622262

  5. Life Cycle Costing.

    ERIC Educational Resources Information Center

    McCraley, Thomas L.

    1985-01-01

    Life cycle costing establishes a realistic comparison of the cost of owning and operating products. The formula of initial cost plus maintenance plus operation divided by useful life identifies the best price over the lifetime of the product purchased. (MLF)

  6. Life Chances Exercise.

    ERIC Educational Resources Information Center

    Miller, Margaret A.

    1992-01-01

    Describes a life chances exercise that helps students identify the life chances that they and society value. Explains that students learn that the attainment of important life chances is related to the family into which one is born. Discusses John Rawls' social theory. Suggests that participants may need to consider alternative systems of economic…

  7. Multi-institutional Prospective Evaluation of Bowel Quality of Life After Prostate External Beam Radiation Therapy Identifies Patient and Treatment Factors Associated With Patient-Reported Outcomes: The PROSTQA Experience

    SciTech Connect

    Hamstra, Daniel A.; Conlon, Anna S.C.; Daignault, Stephanie; Dunn, Rodney L.; Sandler, Howard M.; Hembroff, A. Larry; Zietman, Anthony L.; Kaplan, Irving; Ciezki, Jay; Kuban, Deborah A.; Wei, John T.; Sanda, Martin G.; Michalski, Jeff M.

    2013-07-01

    Purpose: To evaluate patients treated with external beam radiation therapy as part of the multicenter Prostate Cancer Outcomes and Satisfaction with Treatment Quality Assessment (PROSTQA), to identify factors associated with posttreatment patient-reported bowel health-related quality of life (HRQOL). Methods and Materials: Pretreatment characteristics and treatment details among 292 men were evaluated using a general linear mixed model for their association with measured HRQOL by the Expanded Prostate Cancer Index Composite instrument through 2 years after enrollment. Results: Bowel HRQOL had a median score of 100 (interquartile range 91.7-100) pretreatment and 95.8 (interquartile range 83.3-100) at 2 years, representing new moderate/big problems in 11% for urgency, 7% for frequency, 4% for bloody stools, and 8% for an overall bowel problems. Baseline bowel score was the strongest predictor for all 2-year endpoints. In multivariable models, a volume of rectum ≥25% treated to 70 Gy (V70) yielded a clinically significant 9.3-point lower bowel score (95% confidence interval [CI] 16.8-1.7, P=.015) and predicted increased risks for moderate to big fecal incontinence (P=.0008). No other radiation therapy treatment-related variables influenced moderate to big changes in rectal HRQOL. However, on multivariate analyses V70 ≥25% was associated with increases in small, moderate, or big problems with the following: incontinence (3.9-fold; 95% CI 1.1-13.4, P=.03), rectal bleeding (3.6-fold; 95% CI 1.3-10.2, P=.018), and bowel urgency (2.9-fold; 95% CI 1.1-7.6, P=.026). Aspirin use correlated with a clinically significant 4.7-point lower bowel summary score (95% CI 9.0-0.4, P=.03) and an increase in small, moderate, or big problems with bloody stools (2.8-fold; 95% CI 1.2-6.4, P=.018). Intensity modulated radiation therapy was associated with higher radiation therapy doses to the prostate and lower doses to the rectum but did not independently correlate with bowel HRQOL

  8. Life's Still Lifes

    NASA Astrophysics Data System (ADS)

    McIntosh, Harold V.

    The de Bruijn diagram describing those decompositions of the neighborhoods of a one dimensional cellular automaton which conform to predetermined requirements of periodicity and translational symmetry shows how to construct extended configurations satisfying the same requirements. Similar diagrams, formed by stages, describe higher dimensional automata, although they become more laborious to compute with increasing neighborhood size. The procedure is illustrated by computing some still lifes for Conway's game of Life, a widely known two dimensional cellular automaton. This paper is written in September 10, 1988.

  9. Identifying Fossil Bacteria in Martian Materials

    NASA Technical Reports Server (NTRS)

    Westall, F.; McKay, D. S.; Gibson, E. K., Jr.

    1999-01-01

    Within the next decade, robotic missions are going to Mars with the search for evidence for extant and extinct life as at least one of the mission objectives. Moreover, the first Martian samples will be returned to Earth in 2008. It is therefore imperative that we can be certain that we can identify life in Martian rocks. In this paper we will not be discussing extant life but will concentrate on fossil life.

  10. Limited life item management

    NASA Technical Reports Server (NTRS)

    Eaglen, R. L.

    1971-01-01

    Plans are available for age-sensitive hardware management. Control plan identifies shelf life or age control requirements for materials considered age sensitive, use sensitive, or time service or shelf life controlled items, and describes methods of arriving at age controls through adherence to detailed specifications.

  11. Identifying the key elements of an education package to up-skill multidisciplinary adult specialist palliative care teams caring for young adults with life-limiting conditions: an online Delphi study

    PubMed Central

    Sivell, Stephanie; Lidstone, Victoria; Taubert, Mark; Thompson, Catherine; Nelson, Annmarie

    2015-01-01

    Objectives To collect the views of experts to inform the development of an education package for multidisciplinary adult specialist palliative care (SPC) teams caring for young people with life-limiting conditions. Methods A modified online Delphi process collated expert opinion on format, delivery and content of an education package to up-skill adult SPC teams. Round 1 participants (n=44) answered free-text questions, generating items for Round 2. In Round 2, 68 participants rated the extent to which they agreed/disagreed with the items on 5-point Likert-type scales. Median and mean scores assessed the importance of each item. IQR scores assessed level of consensus for each item; items lacking consensus were rerated by 35 participants in Round 3. Results In the Delphi, consensus was reached on a range of suggested formats, on who should deliver the training, and on several clinical, psychosocial and practical topics. Conclusions Development of a continuous/rolling programme of education, tailored for content and mode of delivery and incorporated into working practice is recommended. As a direct outcome of the results of this study, a series of six linked study days has been established, focusing specifically on the issues around caring for young adults with life-limiting conditions and palliative care needs. PMID:24670554

  12. Life's crucible.

    PubMed

    Radetsky, P

    1998-02-01

    Research by German chemists Gunter Wachtershauser and Claudia Huber about the origins of life is reviewed. Other theories about the beginning of life on Earth are examined with comments by noted researchers. PMID:11541839

  13. Family Life.

    ERIC Educational Resources Information Center

    Naturescope, 1986

    1986-01-01

    Focuses on various aspects of mammal family life ranging from ways different species are born to how different mammals are raised. Learning activities include making butter from cream, creating birth announcements for mammals, and playing a password game on family life. (ML)

  14. Life sciences

    SciTech Connect

    Day, L.

    1991-04-01

    This document is the 1989--1990 Annual Report for the Life Sciences Divisions of the University of California/Lawrence Berkeley Laboratory. Specific progress reports are included for the Cell and Molecular Biology Division, the Research Medicine and Radiation Biophysics Division (including the Advanced Light Source Life Sciences Center), and the Chemical Biodynamics Division. 450 refs., 46 figs. (MHB)

  15. [Gifted children! How to identify].

    PubMed

    Revol, O; Bléandonu, G

    2012-03-01

    Recognizing the intellectually gifted child allows one to anticipate the onset of behavioral disorders and to respond to them so as to improve quality of life for these children and their family. Certain signs can draw attention to this phenomenon. The decisive criterion has always been IQ. The notion of intelligence should be broadened and researchers have adventured beyond the purely intellectual competencies, which value most prominently the educational sphere. In addition, the modeling of high potential is currently renewing the approach to this question. This article takes this complexity into account and presents the main criteria used for identifying intellectually gifted children. PMID:22325457

  16. Predicting service life margins

    NASA Technical Reports Server (NTRS)

    Egan, G. F.

    1971-01-01

    Margins are developed for equipment susceptible to malfunction due to excessive time or operation cycles, and for identifying limited life equipment so monitoring and replacing is accomplished before hardware failure. Method applies to hardware where design service is established and where reasonable expected usage prediction is made.

  17. Implementing "A New Life."

    ERIC Educational Resources Information Center

    Further Education Unit, London (England).

    This bulletin, which is intended for senior managers in Great Britain's health, education, and social service sectors who are involved in planning or providing learning programs for adults with severe learning disabilities, identifies key issues in the strategic planning of programs using the packet of materials titled "A New Life." This packet…

  18. Life's timekeeper.

    PubMed

    Neill, David

    2013-03-01

    Life's timekeeper is a 'free-running' intracellular oscillator synchronised across all cells. It runs throughout life splitting lifespan into equal length phases. During the maturational period it controls the overall rate of progression whereas in the post-maturational period it controls the overall rate of ageing. This includes the rate of senescence and hence time to death. As such life's timekeeper equates maturational and post-maturational time, hence explains the tight correlation between these time periods that has existed throughout mammalian evolution. Life's timekeeper is proposed to have played an important role in vertebrate evolution. A slower oscillatory frequency results in proportional life phase prolongation. This leads to increased body and brain size, together with extended lifespan. Higher brain centres, neocortex in mammals, are disproportionately enlarged. Hence behavioural capacity is increased. The extended post-maturational period ensures that there is enough time in order that the behavioural advantages can be fully manifest in the environment. A faster oscillatory frequency would result in proportional life phase reduction. This process however would lead to reduced behavioural capacity, and is hence unlikely to be positively selected. Therefore throughout evolution life's timekeeper has operated to extend lifespan. It has hence functioned to promote longevity as opposed to ageing. PMID:23354279

  19. Extraterrestrial Life

    NASA Technical Reports Server (NTRS)

    Klein, M. J.

    1993-01-01

    Extraterrestrial Intelligence is intelligent life that developed somewhere other than the earth. Such life has not yet been discovered. However, scientific research, including astronomy, biology, planetary science and studies of fossils here on earth have led many scientists to conclude that such life may exist on planets orbiting at least some of the hundreds of billions of stars in our Milky Way Galaxy. Today, some researchers are trying to find evidence for extraterrestrial intelligence. This effort is often called SETI, which stands for Search for Extraterrestrial Intelligence. SETI researchers decided that looking for evidence of their technology might be the best way to discover other intelligent life in the Galaxy. They decided to use large radio telescopes to search the sky over a wide range of radio frequencies...

  20. Defining Life

    PubMed Central

    2010-01-01

    Abstract Any definition is intricately connected to a theory that gives it meaning. Accordingly, this article discusses various definitions of life held in the astrobiology community by considering their connected “theories of life.” These include certain “list” definitions and a popular definition that holds that life is a “self-sustaining chemical system capable of Darwinian evolution.” We then act as “anthropologists,” studying what scientists do to determine which definition-theories of life they constructively hold as they design missions to seek non-terran life. We also look at how constructive beliefs about biosignatures change as observational data accumulate. And we consider how a definition centered on Darwinian evolution might itself be forced to change as supra-Darwinian species emerge, including in our descendents, and consider the chances of our encountering supra-Darwinian species in our exploration of the Cosmos. Last, we ask what chemical structures might support Darwinian evolution universally; these structures might be universal biosignatures. Key Words: Evolution—Life—Life detection—Biosignatures. Astrobiology 10, 1021–1030. PMID:21162682

  1. Gang Identifiers and Terminology.

    ERIC Educational Resources Information Center

    Cantrell, Mary Lynn

    1992-01-01

    Provides lists of gang identifiers and terminology. Suggests that, to find out names and associated identifiers of local gangs, readers should talk to their local police. Included in listing are descriptions of gang-related symbols, physical signals, graffiti, slogans, right-left rules, colors, clothing, jewelry, hair styles, and fingernails. Also…

  2. Advanced life support study

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Summary reports on each of the eight tasks undertaken by this contract are given. Discussed here is an evaluation of a Closed Ecological Life Support System (CELSS), including modeling and analysis of Physical/Chemical Closed Loop Life Support (P/C CLLS); the Environmental Control and Life Support Systems (ECLSS) evolution - Intermodule Ventilation study; advanced technologies interface requirements relative to ECLSS; an ECLSS resupply analysis; the ECLSS module addition relocation systems engineering analysis; an ECLSS cost/benefit analysis to identify rack-level interface requirements of the alternate technologies evaluated in the ventilation study, with a comparison of these with the rack level interface requirements for the baseline technologies; advanced instrumentation - technology database enhancement; and a clean room survey and assessment of various ECLSS evaluation options for different growth scenarios.

  3. Lake Life.

    ERIC Educational Resources Information Center

    Ohrn, Deborah Gore, Ed.

    1993-01-01

    This quarterly publication of the State Historical Society of Iowa features articles and activities for elementary school students. This summer issue focuses on the topic of lake life. The issue includes the following features: (1) "Where the Lakes Are Map"; (2) "Letter from the Lake"; (3) "Lake People"; (4) "Spirit Lake"; (5) "Lake Manawa"; (6)…

  4. Identifying oncological emergencies.

    PubMed

    Guddati, Achuta K; Kumar, Nilay; Segon, Ankur; Joy, Parijat S; Marak, Creticus P; Kumar, Gagan

    2013-01-01

    Prompt identification and treatment of life-threatening oncological conditions is of utmost importance and should always be included in the differential diagnosis. Oncological emergencies can have a myriad of presentations ranging from mechanical obstruction due to tumor growth to metabolic conditions due to abnormal secretions from the tumor. Notably, hematologic and infectious conditions may complicate the presentation of oncological emergencies. Advanced testing and imaging is generally required to recognize these serious presentations of common malignancies. Early diagnosis and treatment of these conditions can significantly affect the patient's clinical outcome. PMID:23873016

  5. Extraterrestrial Life: Processes, Implications, and Applications.

    ERIC Educational Resources Information Center

    Molyson, Joseph T.

    Provided are background materials relating the study of extraterrestrial life to common biological principles. A history of the creation of the sun and earth is included, as well as a summary of one current theory regarding the origin of life on earth. Relationships are identified regarding possible origins of life on other planets. Factors…

  6. Metal alloy identifier

    DOEpatents

    Riley, William D.; Brown, Jr., Robert D.

    1987-01-01

    To identify the composition of a metal alloy, sparks generated from the alloy are optically observed and spectrographically analyzed. The spectrographic data, in the form of a full-spectrum plot of intensity versus wavelength, provide the "signature" of the metal alloy. This signature can be compared with similar plots for alloys of known composition to establish the unknown composition by a positive match with a known alloy. An alternative method is to form intensity ratios for pairs of predetermined wavelengths within the observed spectrum and to then compare the values of such ratios with similar values for known alloy compositions, thereby to positively identify the unknown alloy composition.

  7. Identifying Technical Vocabulary

    ERIC Educational Resources Information Center

    Chung, Teresa Mihwa; Nation, Paul

    2004-01-01

    This study compared four different approaches to identifying technical words in an anatomy text. The first approach used a four step rating scale, and was used as the comparison for evaluating the other three approaches. It had a high degree of reliability. The least successful approach was that using clues provided by the writer such as labels in…

  8. Identifying and Managing Risk.

    ERIC Educational Resources Information Center

    Abraham, Janice M.

    1999-01-01

    The role of the college or university chief financial officer in institutional risk management is (1) to identify risk (physical, casualty, fiscal, business, reputational, workplace safety, legal liability, employment practices, general liability), (2) to develop a campus plan to reduce and control risk, (3) to transfer risk, and (4) to track and…

  9. LIFE, Life Investigation For Enceladus

    NASA Astrophysics Data System (ADS)

    Tsou, Peter; Kanic, I.; Lane, C.; Sotin, C.; Spilker, L.; Spilker, T.; Strange, N.

    2009-09-01

    Enceladus, a small icy moon of Saturn, is one of NASA outer planet life search targets and unique in its current active jets. As with comets, this enables a low-cost flyby sample return mission like STARDUST. Samples from Enceladus will expand our in-depth knowledge of "life” and allow us to effectively plan for future missions. Cassini found Enceladus’ jets composed of fine icy particules and hydrocarbons. Saturn's E ring is sustained by these jets for at least the last 300 years. Clearly there is a subsurface heat source generating such jets. Several theories for the origin of life on Earth would also apply to Enceladus; thus, obtaining the samples from the plume will provide breakthrough understandings of the nature of current or past life markers. The highly detailed analyses of Apollo and STARDUST samples revolutionized our knowledge of the Moon and comets and provided fundamental insights into remarkable processes that occur early in the formation of the Solar System. These in-depth analyses are not possible with astronomical remote sensing or in-situ instrumentations. Since the duration of these plumes is unknown, it is imperative to capture these samples by the earliest flight opportunity- the Discovery AO by the fall of 2009. For LIFE, we have a trajectory to encounter the plume at less than 4 km/s ensuring a more gentle capture of organics than STARDUST at 6 km/s. With less than 14-year mission duration, the samples can be returned to Earth before 2029. By capitalizing on the STARDUST heritage of design-to-cost mindset, the mission cost can be controlled. For cost reduction, the upcoming Discovery AO offers unique free ASRGs and allows the use of Jupiter for gravity assist.

  10. Life lessons

    PubMed Central

    2015-01-01

    Summary Reminiscing about his younger self: “I mean I can’t very well just 86 [in American slang, to “86” is to eject, remove, or discard someone or something, J.R.N.] this guy from my life. On the other hand, if through some as yet undeveloped technology I were to run into him today, how comfortable would I feel about lending him money, or for that matter even stepping down the street to have a beer and talk over old times?” ― Thomas Pynchon, Slow Learner PMID:26734084

  11. Extraterrestrial Life: Life on Mars - Then and Now

    NASA Technical Reports Server (NTRS)

    Arrhenius, Gustaf; Mojzsis, Stephen

    1996-01-01

    The recent claim to have identified possible signs of ancient life on Mars has been widely publicized and discussed. The authors conceded that none of the half-dozen pieces of evidence adduced in their paper individually provided strong support for extraterrestrial life, though they argued that the pieces added up to a case worth considering. Most - perhaps all - of the observed phenomena have counterparts in the inorganic world, so even the combination does not make a compelling case that there was ever life on Mars. Nevertheless, the importance of the problem has justified bringing the results to general attention. The paper has focussed interest on the origin and possible ubiquity of life, and on how we can design techniques capable of giving a more definitive answer to the question of whether there is, or has ever been, life elsewhere in the Universe.

  12. An Aristotelian Account of Minimal Chemical Life

    NASA Astrophysics Data System (ADS)

    Bedau, Mark A.

    2010-12-01

    This paper addresses the open philosophical and scientific problem of explaining and defining life. This problem is controversial, and there is nothing approaching a consensus about what life is. This raises a philosophical meta-question: Why is life so controversial and so difficult to define? This paper proposes that we can attribute a significant part of the controversy over life to use of a Cartesian approach to explaining life, which seeks necessary and sufficient conditions for being an individual living organism, out of the context of other organisms and the abiotic environment. The Cartesian approach contrasts with an Aristotelian approach to explaining life, which considers life only in the whole context in which it actually exists, looks at the characteristic phenomena involving actual life, and seeks the deepest and most unified explanation for those phenomena. The phenomena of life might be difficult to delimit precisely, but it certainly includes life's characteristic hallmarks, borderline cases, and puzzles. The Program-Metabolism-Container (PMC) model construes minimal chemical life as a functionally integrated triad of chemical systems, which are identified as the Program, Metabolism, and Container. Rasmussen diagrams precisely depict the functional definition of minimal chemical life. The PMC model illustrates the Aristotelian approach to life, because it explains eight of life's hallmarks, one of life's borderline cases (the virus), and two of life's puzzles.

  13. Life sciences.

    PubMed

    Schmidt, Gregory K

    2002-12-01

    Space life sciences research activities are reviewed for the year. Highlights of animal studies were the first long-term flight of an animal enclosure module and an avian development facility on STS-108. Plant research efforts focused on a biomass production system for eventual use on the International Space Station (ISS), the PESTO experiment on ISS, and screening of several salad crop varieties for potential use in space. Health-related studies included the Martian Radiation Environment Experiment (MARIE) on the Mars Odyssey mission, presentation of results from NASA's Biomolecular Physics and Chemistry Program, and research related to human liver cell function in space through an agreement with StelSys. In industry and academia, a memorandum of understanding was signed between NASA and the biotechnology industry to enhance communication between NASA and the industry, expand commercial biotechnology space research and development, and expand formal and informal education of industry and the public regarding biotechnology and space research. NASA selected Purdue University to lead an NSCORT for advanced life support research to develop technologies to enable long-duration planetary mission and sustain human space colonies. PMID:12506925

  14. On identified predictive control

    NASA Technical Reports Server (NTRS)

    Bialasiewicz, Jan T.

    1993-01-01

    Self-tuning control algorithms are potential successors to manually tuned PID controllers traditionally used in process control applications. A very attractive design method for self-tuning controllers, which has been developed over recent years, is the long-range predictive control (LRPC). The success of LRPC is due to its effectiveness with plants of unknown order and dead-time which may be simultaneously nonminimum phase and unstable or have multiple lightly damped poles (as in the case of flexible structures or flexible robot arms). LRPC is a receding horizon strategy and can be, in general terms, summarized as follows. Using assumed long-range (or multi-step) cost function the optimal control law is found in terms of unknown parameters of the predictor model of the process, current input-output sequence, and future reference signal sequence. The common approach is to assume that the input-output process model is known or separately identified and then to find the parameters of the predictor model. Once these are known, the optimal control law determines control signal at the current time t which is applied at the process input and the whole procedure is repeated at the next time instant. Most of the recent research in this field is apparently centered around the LRPC formulation developed by Clarke et al., known as generalized predictive control (GPC). GPC uses ARIMAX/CARIMA model of the process in its input-output formulation. In this paper, the GPC formulation is used but the process predictor model is derived from the state space formulation of the ARIMAX model and is directly identified over the receding horizon, i.e., using current input-output sequence. The underlying technique in the design of identified predictive control (IPC) algorithm is the identification algorithm of observer/Kalman filter Markov parameters developed by Juang et al. at NASA Langley Research Center and successfully applied to identification of flexible structures.

  15. Why did life emerge?

    NASA Astrophysics Data System (ADS)

    Annila, Arto; Annila, Erkki

    2008-10-01

    Many mechanisms, functions and structures of life have been unraveled. However, the fundamental driving force that propelled chemical evolution and led to life has remained obscure. The second law of thermodynamics, written as an equation of motion, reveals that elemental abiotic matter evolves from the equilibrium via chemical reactions that couple to external energy towards complex biotic non-equilibrium systems. Each time a new mechanism of energy transduction emerges, e.g., by random variation in syntheses, evolution prompts by punctuation and settles to a stasis when the accessed free energy has been consumed. The evolutionary course towards an increasingly larger energy transduction system accumulates a diversity of energy transduction mechanisms, i.e. species. The rate of entropy increase is identified as the fitness criterion among the diverse mechanisms, which places the theory of evolution by natural selection on the fundamental thermodynamic principle with no demarcation line between inanimate and animate.

  16. List identifies threatened ecosystems

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2012-09-01

    The International Union for Conservation of Nature (IUCN) announced on 9 September that it will develop a new Red List of Ecosystems that will identify which ecosystems are vulnerable or endangered. The list, which is modeled on the group's Red List of Threatened Species™, could help to guide conservation activities and influence policy processes such as the Convention on Biological Diversity, according to the group. “We will assess the status of marine, terrestrial, freshwater, and subterranean ecosystems at local, regional, and global levels,” stated Jon Paul Rodriguez, leader of IUCN's Ecosystems Red List Thematic Group. “The assessment can then form the basis for concerted implementation action so that we can manage them sustainably if their risk of collapse is low or restore them if they are threatened and then monitor their recovery.”

  17. Identifying and Inactivating Bacterial Spores

    NASA Technical Reports Server (NTRS)

    Newcombe, David; Dekas, Anne; Venkateswaran, Kasthuri

    2009-01-01

    Problems associated with, and new strategies for, inactivating resistant organisms like Bacillus canaveralius (found at Kennedy Space Center during a survey of three NASA cleanrooms) have been defined. Identifying the particular component of the spore that allows its heightened resistance can guide the development of sterilization procedures that are targeted to the specific molecules responsible for resistance, while avoiding using unduly harsh methods that jeopardize equipment. The key element of spore resistance is a multilayered protein shell that encases the spore called the spore coat. The coat of the best-studied spore-forming microbe, B. subtilis, consists of at least 45 proteins, most of which are poorly characterized. Several protective roles for the coat are well characterized including resistance to desiccation, large toxic molecules, ortho-phthalaldehyde, and ultraviolet (UV) radiation. One important long-term specific goal is an improved sterilization procedure that will enable NASA to meet planetary protection requirements without a terminal heat sterilization step. This would support the implementation of planetary protection policies for life-detection missions. Typically, hospitals and government agencies use biological indicators to ensure the quality control of sterilization processes. The spores of B. canaveralius that are more resistant to osmotic stress would serve as a better biological indicator for potential survival than those in use currently.

  18. Identifying potential academic leaders

    PubMed Central

    White, David; Krueger, Paul; Meaney, Christopher; Antao, Viola; Kim, Florence; Kwong, Jeffrey C.

    2016-01-01

    Objective To identify variables associated with willingness to undertake leadership roles among academic family medicine faculty. Design Web-based survey. Bivariate and multivariable analyses (logistic regression) were used to identify variables associated with willingness to undertake leadership roles. Setting Department of Family and Community Medicine at the University of Toronto in Ontario. Participants A total of 687 faculty members. Main outcome measures Variables related to respondents’ willingness to take on various academic leadership roles. Results Of all 1029 faculty members invited to participate in the survey, 687 (66.8%) members responded. Of the respondents, 596 (86.8%) indicated their level of willingness to take on various academic leadership roles. Multivariable analysis revealed that the predictors associated with willingness to take on leadership roles were as follows: pursuit of professional development opportunities (odds ratio [OR] 3.79, 95% CI 2.29 to 6.27); currently holding at least 1 leadership role (OR 5.37, 95% CI 3.38 to 8.53); a history of leadership training (OR 1.86, 95% CI 1.25 to 2.78); the perception that mentorship is important for one’s current role (OR 2.25, 95% CI 1.40 to 3.60); and younger age (OR 0.97, 95% CI 0.95 to 0.99). Conclusion Willingness to undertake new or additional leadership roles was associated with 2 variables related to leadership experiences, 2 variables related to perceptions of mentorship and professional development, and 1 demographic variable (younger age). Interventions that support opportunities in these areas might expand the pool and strengthen the academic leadership potential of faculty members. PMID:27331226

  19. Fat tissue and long life.

    PubMed

    Bluher, Matthias

    2008-01-01

    Studies over the last several years have revealed important roles of the body fat content, caloric intake and nutrition, insulin/IGF-1 signaling systems, and pathways involved in oxidative stress and control of protein acetylation on life span. Although the discovery of longevity genes supports the concept that life span is genetically determined, adipose tissue seems to be a pivotal organ in the aging process and in the determination of life span. Leanness and caloric restriction have been shown to increase longevity in organisms ranging from yeast to mammals. Increased longevity in mice with a fat-specific disruption of the insulin receptor gene (FIRKO) suggests that reduced adiposity, even in the presence of normal or increased food intake, leads to an extended life span. Reduced fat mass has an impact on longevity in a number of other model organisms. In Drosophila, a specific reduction in the fat body through overexpression of forkhead type transcription factor (dFOXO) extends life span. Sirtuin 1 (SIRT1), the mammalian ortholog of the life-extending yeast gene silent information regulator 2 (SIR2), was proposed to be involved in the molecular mechanisms linking life span to adipose tissue. Moreover, in the control of human aging and longevity, one of the striking physiological characteristics identified in centenarians is their greatly increased insulin sensitivity even compared with younger individuals. On the other hand, overweight and obesity seem to be associated with decreased life span in humans. In addition, it was recently shown that modifiable risk factors during the later years of life, including smoking, obesity, and hypertension, are associated not only with lower life expectancy, but also with poor health and function during older age. There is growing evidence that the effect of reduced adipose tissue mass on life span could be due to the prevention of obesity-related metabolic disorders including type 2 diabetes and atherosclerosis. PMID

  20. Life's Solution

    NASA Astrophysics Data System (ADS)

    Morris, Simon Conway

    2003-09-01

    Life's Solution builds a persuasive case for the predictability of evolutionary outcomes. The case rests on a remarkable compilation of examples of convergent evolution, in which two or more lineages have independently evolved similar structures and functions. The examples range from the aerodynamics of hovering moths and hummingbirds to the use of silk by spiders and some insects to capture prey. Going against the grain of Darwinian orthodoxy, this book is a must read for anyone grappling with the meaning of evolution and our place in the Universe. Simon Conway Morris is the Ad Hominen Professor in the Earth Science Department at the University of Cambridge and a Fellow of St. John's College and the Royal Society. His research focuses on the study of constraints on evolution, and the historical processes that lead to the emergence of complexity, especially with respect to the construction of the major animal body parts in the Cambrian explosion. Previous books include The Crucible of Creation (Getty Center for Education in the Arts, 1999) and co-author of Solnhofen (Cambridge, 1990). Hb ISBN (2003) 0-521-82704-3

  1. Life's Solution

    NASA Astrophysics Data System (ADS)

    Morris, Simon Conway

    2004-11-01

    Life's Solution builds a persuasive case for the predictability of evolutionary outcomes. The case rests on a remarkable compilation of examples of convergent evolution, in which two or more lineages have independently evolved similar structures and functions. The examples range from the aerodynamics of hovering moths and hummingbirds to the use of silk by spiders and some insects to capture prey. Going against the grain of Darwinian orthodoxy, this book is a must read for anyone grappling with the meaning of evolution and our place in the Universe. Simon Conway Morris is the Ad Hominen Professor in the Earth Science Department at the University of Cambridge and a Fellow of St. John's College and the Royal Society. His research focuses on the study of constraints on evolution, and the historical processes that lead to the emergence of complexity, especially with respect to the construction of the major animal body parts in the Cambrian explosion. Previous books include The Crucible of Creation (Getty Center for Education in the Arts, 1999) and co-author of Solnhofen (Cambridge, 1990). Hb ISBN (2003) 0-521-82704-3

  2. Identifying Young, Nearby Stars

    NASA Technical Reports Server (NTRS)

    Webb, Rich; Song, Inseok; Zuckerman, Ben; Bessell, Mike

    2001-01-01

    Young stars have certain characteristics, e.g., high atmospheric abundance of lithium and chromospheric activity, fast rotation, distinctive space motion and strong X-ray flux compared to that of older main sequence stars. We have selected a list of candidate young (<100Myr) and nearby (<60pc) stars based on their space motion and/or strong X-ray flux. To determine space motion of a star, one needs to know its coordinates (RA, DEC), proper motion, distance, and radial velocity. The Hipparcos and Tycho catalogues provide all this information except radial velocities. We anticipate eventually searching approx. 1000 nearby stars for signs of extreme youth. Future studies of the young stars so identified will help clarify the formation of planetary systems for times between 10 and 100 million years. Certainly, the final output of this study will be a very useful resource, especially for adaptive optics and space based searches for Jupiter-mass planets and dusty proto-planetary disks. We have begun spectroscopic observations in January, 2001 with the 2.3 m telescope at Siding Spring Observatory (SSO) in New South Wales, Australia. These spectra will be used to determine radial velocities and other youth indicators such as Li 6708A absorption strength and Hydrogen Balmer line intensity. Additional observations of southern hemisphere stars from SSO are scheduled in April and northern hemisphere observations will take place in May and July at the Lick Observatory of the University of California. AT SSO, to date, we have observed about 100 stars with a high resolution spectrometer (echelle) and about 50 stars with a medium spectral resolution spectrometer (the "DBS"). About 20% of these stars turn out to be young stars. Among these, two especially noteworthy stars appear to be the closest T-Tauri stars ever identified. Interestingly, these stars share the same space motions as that of a very famous star with a dusty circumstellar disk--beta Pictoris. This new finding better

  3. Dying and multiplying life.

    PubMed

    Rodríguez-Arias, David

    2014-09-01

    It was only after James P. Lovette's death, in 2006, that I discovered that the twenty-four-year-old colleague and friend with whom I had spent so many afternoons debating issues in organ transplantation had been the first successful child heart transplantee in the world and one of the longest-living survivors of a second transplant. During the years we met, he never even hinted at the fact that three different hearts had beaten in his chest. The revelation that his life had been an almost uninterrupted chain of medical challenges suddenly made me appreciate his quirkiness in a whole new light. Organ transplantation crudely exemplifies a traditional moral dilemma between means and ends: in order to save a life, someone else has to die. Bioethicists involved in this field have the role of identifying the ethical issues surrounding organ donation and helping others to argue in an intelligible and convincing way. In my view, bioethicists have the obligation to foster a discussion as open and transparent as possible on these matters. Still, I sometimes fear that I may be helping to cause unnecessary harms to potential recipients who are desperately waiting for a vital organ. Scholars would be chillingly cold if their quest for truth systematically came at the cost of lives lost. Every life can be meaningful and provide meaning to many others. This is true even with organ recipients, who often have short lives full of considerable suffering. PMID:25231665

  4. Harnessing our very life.

    PubMed

    Wills, Peter R; Williams, David L F; Trussell, Denys; Mann, L R B

    2013-01-01

    The Aristotelian ideas of nature (physis) and technology (techné) are taken as a starting point for understanding what it would mean for technology to be truly living. Heidegger's critique of the conflation of scientific and technological thinking in the current era is accepted as demonstrating that humanity does not have a deep enough appreciation of the nature of life to harness its essence safely. Could the vision of harnessing life be realized, which we strongly doubt, living technology would give selected humans transforming powers that could be expected to exacerbate, rather than solve, current global problems. The source of human purposefulness, and hence of both technology and ethics, is identified in nature's emergent capability to instantiate informational representations in material forms. Ethics that are properly grounded in an appreciation of intrinsic value, especially that of life, demand that proposals to give humanity the capabilities of living technology address the social, political, economic, and environmental problems inherent in its development and potential deployment. Before any development is embarked on, steps must be taken to avoid living technology, whatever the term eventually designates, becoming available for destructive or antisocial purposes such as those that might devastate humanity or irrevocably damage the natural world. PMID:23889745

  5. 19 CFR 207.27 - Short life cycle products.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Short life cycle products. 207.27 Section 207.27... SUBSIDIZED EXPORTS TO THE UNITED STATES Final Determinations, Short Life Cycle Products § 207.27 Short life... scope of the product category into which to classify the short life cycle merchandise identified by...

  6. EZID: Long term identifiers made easy (Invited)

    NASA Astrophysics Data System (ADS)

    Starr, J.

    2013-12-01

    Scholarly research is producing ever increasing amounts of digital research data, and this data should be managed throughout the research life cycle both as part of good scientific practice, but also to comply with funder mandates, such as the 2013 OSTP Public Access Memo (http://www.whitehouse.gov/sites/default/files/microsites/ostp/ostp_public_access_memo_2013.pdf). By assigning unique and persistent identifiers to data objects, data managers can gain control and flexibility over what can be a daunting task. This is due to the fact that the objects can be moved to new locations without disruption to links, as long as the identifier target is maintained. EZID is a tool that makes assigning and maintaining unique, persistent identifiers easy. It was designed and built by California Digital Library (CDL) and has both a user interface and a RESTful API. EZID currently offers services for two globally unique, persistent identifier schemes: Digital Object Identifiers (DOIs) and Archival Resource Keys (ARKs). DOIs are identifiers originating from the publishing world and are in widespread use for journal articles. CDL is able to offer DOIs because of being a founding member of DataCite (http://www.datacite.org/), an international consortium established to provide easier access to scientific research data on the Internet. ARKs are identifiers originating from the library, archive and museum community. Like DOIs, they become persistent when the objects and identifier forwarding information is maintained. DOIs and ARKs have a key role in data management and, therefore, in data management plans. DOIs are the recommended identifier for use in data citation, and ARKs provide the maximum flexibility needed for data documentation and management throughout the early phases of a project. The two identifier schemes are able to be used together, and EZID is made to work with both. EZID clients, coming from education, research, government, and the private sector, are utilizing the

  7. Is the Good Life the Easy Life?

    ERIC Educational Resources Information Center

    Scollon, Christie Napa; King, Laura A.

    2004-01-01

    Three studies examined folk concepts of the good life. Participants rated the desirability and moral goodness of a life as a function of the happiness, meaning, and effort experienced. Happiness and meaning were solid predictors of the good life, replicating King and Napa (1998). Study 1 (N = 381) included wealth as an additional factor. Results…

  8. Skills for Life. Teacher's Resource Materials.

    ERIC Educational Resources Information Center

    Texas Tech Univ., Lubbock. Home Economics Curriculum Center.

    This document contains research-based resource materials designed to help teachers teach life skills to students in grades 7-12. It contains eight units that cover life skill categories identified through research. Each unit consists of several self-contained modules that can be taught in any sequence and incorporated into a variety of courses.…

  9. Career Exploration in the Life Sciences.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Center for Vocational and Technical Education.

    The purpose of the teacher's guide is to acquaint junior high school students with occupations in the life sciences. By identifying life science and exploring the areas of biology (ecology and zoology) and medicine, students may become aware of the functions of the people involved in these areas and the value of their work. The material in the…

  10. Life Course Impacts of Mild Intellectual Deficits

    ERIC Educational Resources Information Center

    Seltzer, Marsha Mailick; Floyd, Frank; Greenberg, Jan; Lounds, Julie; Lindstrom, Mary; Hong, Jinkuk

    2005-01-01

    We identified 201 individuals who obtained IQs of 85 or below in high school and participated in the Wisconsin Longitudinal Study (a prospective longitudinal study that followed sample members from age 18 through age 53). Their life course development was contrasted with their siblings who obtained IQs above 100. Life course outcomes were assessed…

  11. Life Events, Sibling Warmth, and Youths' Adjustment

    ERIC Educational Resources Information Center

    Waite, Evelyn B.; Shanahan, Lilly; Calkins, Susan D.; Keane, Susan P.; O'Brien, Marion

    2011-01-01

    Sibling warmth has been identified as a protective factor from life events, but stressor-support match-mismatch and social domains perspectives suggest that sibling warmth may not efficiently protect youths from all types of life events. We tested whether sibling warmth moderated the association between each of family-wide, youths' personal, and…

  12. Migration and Life of Hispanics in Utah.

    ERIC Educational Resources Information Center

    Gallenstein, Nancy L.

    This paper presents a historical and cultural overview of the migration and life of Hispanics in Utah and identifies three themes: search for a better life, need for and acquisition of a sense of belonging, and substance of the Hispanic people. Over the past 4 centuries, Hispanics have migrated to Utah from New Mexico, Mexico, and Central and…

  13. LIFE CYCLE ASSESSMENT: AN INTERNATIONAL EXPERIENCE

    EPA Science Inventory

    Life Cycle Assessment (LCA) is used to evaluate environmental burdens associated with a product, process or activity by identifying and quantifying relevant inputs and outputs of the defined system and evaluating their potential impacts. This article outlines the four components ...

  14. 41 CFR 101-27.205 - Shelf-life codes.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Shelf-life codes. 101-27...-Management of Shelf-Life Materials § 101-27.205 Shelf-life codes. Shelf-life items shall be identified by use of a one-digit code to provide for uniform coding of shelf-life materials by all agencies. (a)...

  15. Actinides and Life's Origins

    NASA Astrophysics Data System (ADS)

    Adam, Zachary

    2007-12-01

    There are growing indications that life began in a radioactive beach environment. A geologic framework for the origin or support of life in a Hadean heavy mineral placer beach has been developed, based on the unique chemical properties of the lower-electronic actinides, which act as nuclear fissile and fertile fuels, radiolytic energy sources, oligomer catalysts, and coordinating ions (along with mineralogically associated lanthanides) for prototypical prebiotic homonuclear and dinuclear metalloenzymes. A four-factor nuclear reactor model was constructed to estimate how much uranium would have been required to initiate a sustainable fission reaction within a placer beach sand 4.3 billion years ago. It was calculated that about 1-8 weight percent of the sand would have to have been uraninite, depending on the weight percent, uranium enrichment, and quantity of neutron poisons present within the remaining placer minerals. Radiolysis experiments were conducted with various solvents with the use of uranium- and thorium-rich minerals (metatorbernite and monazite, respectively) as proxies for radioactive beach sand in contact with different carbon, hydrogen, oxygen, and nitrogen reactants. Radiation bombardment ranged in duration of exposure from 3 weeks to 6 months. Low levels of acetonitrile (estimated to be on the order of parts per billion in concentration) were conclusively identified in 2 setups and tentatively indicated in a 3rd by gas chromatography/mass spectrometry. These low levels have been interpreted within the context of a Hadean placer beach prebiotic framework to demonstrate the promise of investigating natural nuclear reactors as power production sites that might have assisted the origins of life on young rocky planets with a sufficiently differentiated crust/mantle structure. Future investigations are recommended to better quantify the complex relationships between energy release, radioactive grain size, fissionability, reactant phase, phosphorus

  16. Actinides and Life's Origins.

    PubMed

    Adam, Zachary

    2007-12-01

    There are growing indications that life began in a radioactive beach environment. A geologic framework for the origin or support of life in a Hadean heavy mineral placer beach has been developed, based on the unique chemical properties of the lower-electronic actinides, which act as nuclear fissile and fertile fuels, radiolytic energy sources, oligomer catalysts, and coordinating ions (along with mineralogically associated lanthanides) for prototypical prebiotic homonuclear and dinuclear metalloenzymes. A four-factor nuclear reactor model was constructed to estimate how much uranium would have been required to initiate a sustainable fission reaction within a placer beach sand 4.3 billion years ago. It was calculated that about 1-8 weight percent of the sand would have to have been uraninite, depending on the weight percent, uranium enrichment, and quantity of neutron poisons present within the remaining placer minerals. Radiolysis experiments were conducted with various solvents with the use of uraniumand thorium-rich minerals (metatorbernite and monazite, respectively) as proxies for radioactive beach sand in contact with different carbon, hydrogen, oxygen, and nitrogen reactants. Radiation bombardment ranged in duration of exposure from 3 weeks to 6 months. Low levels of acetonitrile (estimated to be on the order of parts per billion in concentration) were conclusively identified in 2 setups and tentatively indicated in a 3(rd) by gas chromatography/mass spectrometry. These low levels have been interpreted within the context of a Hadean placer beach prebiotic framework to demonstrate the promise of investigating natural nuclear reactors as power production sites that might have assisted the origins of life on young rocky planets with a sufficiently differentiated crust/mantle structure. Future investigations are recommended to better quantify the complex relationships between energy release, radioactive grain size, fissionability, reactant phase, phosphorus

  17. Rock Surfaces as Life Indicators: New Ways to Demonstrate Life and Traces of Former Life

    NASA Astrophysics Data System (ADS)

    Gorbushina, Anna A.; Krumbein, Wolfgang E.; Volkmann, Marc

    2002-06-01

    Life and its former traces can only be detected from space when they are abundant and exposed to the planetary atmosphere at the moment of investigation by orbiters. Exposed rock surfaces present a multifractal labyrinth of niches for microbial life. Based upon our studies of highly stress-resistant microcolonial fungi of stone monument and desert rock surfaces, we propose that microbial biofilms that develop and become preserved on rock surfaces can be identified remotely by the following characteristics: (1) the existence of spectroscopically identifiable compounds that display unique adsorption, diffraction, and reflection patterns characteristic of biogenerated organic compounds (e.g., chlorophylls, carotenes, melanins, and possibly mycosporines), (2) demonstrably biogenic geomorphological features (e.g., biopitting, biochipping, and bioexfoliation), and (3) biominerals produced in association with biofilms that occupy rock surfaces (e.g., oxalates, forsterite, and special types of carbonates, sulfides, and silicates). Such traces or biosignatures of former life could provide macroscopically visible morphotypes and chemically identifiable products uniquely indicative of life.

  18. The Origin of Life

    ERIC Educational Resources Information Center

    Hodson, D.

    1975-01-01

    Presents an outline of lectures given on this topic to British secondary students. Man's various ideas about the origin of life are included in three categories: those that consider life to have been created by a Divine Being; those that consider life to have developed from non-living matter; and those that consider life to be eternal. (MLH)

  19. The algorithmic origins of life

    PubMed Central

    Walker, Sara Imari; Davies, Paul C. W.

    2013-01-01

    Although it has been notoriously difficult to pin down precisely what is it that makes life so distinctive and remarkable, there is general agreement that its informational aspect is one key property, perhaps the key property. The unique informational narrative of living systems suggests that life may be characterized by context-dependent causal influences, and, in particular, that top-down (or downward) causation—where higher levels influence and constrain the dynamics of lower levels in organizational hierarchies—may be a major contributor to the hierarchal structure of living systems. Here, we propose that the emergence of life may correspond to a physical transition associated with a shift in the causal structure, where information gains direct and context-dependent causal efficacy over the matter in which it is instantiated. Such a transition may be akin to more traditional physical transitions (e.g. thermodynamic phase transitions), with the crucial distinction that determining which phase (non-life or life) a given system is in requires dynamical information and therefore can only be inferred by identifying causal architecture. We discuss some novel research directions based on this hypothesis, including potential measures of such a transition that may be amenable to laboratory study, and how the proposed mechanism corresponds to the onset of the unique mode of (algorithmic) information processing characteristic of living systems. PMID:23235265

  20. Defending definitions of life.

    PubMed

    Mix, Lucas John

    2015-01-01

    Over the past 10 years, it has become unpopular to talk about definitions of life, under the assumption that attempts at a precise definition are counterproductive. Recent attempts have failed to meet strict philosophical criteria for definitions and have failed to reach consensus. I argue that provisional definitions are necessary for clear communications. Our current knowledge of biology justifies a number of universal claims about the category of life. Whether or not "life" represents a natural category, it maps to a number of important, observable processes. Given the importance of those processes and the extent of our knowledge, plural explicit definitions of life (and related categories) will be necessary for progress in astrobiology and origin-of-life studies as well as biology in general. I propose concrete categories related to, but not necessarily coextensive with, life for clear communication and hypothesis formation: Woese life, Darwin life, Haldane life. PMID:25415254

  1. Planetary life: why and how?

    NASA Astrophysics Data System (ADS)

    Pratt, Andy; Kerr, William

    2012-07-01

    Understanding life in an astrobiological context requires that we understand why and how life emerged on earth. We report on the elaboration and preliminary testing of our recent model for the origin of life (Pratt, 2011). This model identifies key components, including availability of chemicals and geochemical energy sources, required for the emergence of planetary life. The model is based on the theory (Russell and Kanik, 2010) that life emerged as a mechanism for the dissipation of the intrinsic geochemical energy gradient of the planet. It proposes that life is founded on an ongoing chemical energy flux that can be harnessed more efficiently by autocatalytic networks of reactions than by direct chemical processes. Feedback and selection mechanisms are required to foster the apparently irreducible complexity found in cells. We posit that selective solubilisation in a hydrothermal flow system was a key mechanism that underpinned the emergence of life. Amongst other things, earthly cells are dependent on a combination of organic molecules, iron (for electron-transfer and catalysis) and phosphate (e.g. for digital information). Soluble aqueous systems that include all these components are constrained by precipitation chemistry (de Zwart et al., 2004). We propose that in situ abiological carbon fixation produced organic molecules that, in turn, led to more active carbon fixation catalysts and hence more efficient reduction of carbon oxides. By encapsulating free iron ions, these organic molecules also facilitated the solubilisation of phosphate species which thereby became integrated within this expanding autocatalytic network. We have evaluated the competitive solubility of phosphate species in the presence of iron and organic moieties to test this theory and provide evidence that this could act as positive feedback loop for a form of prebiological evolution that underpinned the emergence of complex cells. References, Pratt, A. J. (2011) Prebiological Evolution and

  2. Stochastic control system parameter identifiability

    NASA Technical Reports Server (NTRS)

    Lee, C. H.; Herget, C. J.

    1975-01-01

    The parameter identification problem of general discrete time, nonlinear, multiple input/multiple output dynamic systems with Gaussian white distributed measurement errors is considered. The knowledge of the system parameterization was assumed to be known. Concepts of local parameter identifiability and local constrained maximum likelihood parameter identifiability were established. A set of sufficient conditions for the existence of a region of parameter identifiability was derived. A computation procedure employing interval arithmetic was provided for finding the regions of parameter identifiability. If the vector of the true parameters is locally constrained maximum likelihood (CML) identifiable, then with probability one, the vector of true parameters is a unique maximal point of the maximum likelihood function in the region of parameter identifiability and the constrained maximum likelihood estimation sequence will converge to the vector of true parameters.

  3. Multiple origins of life

    NASA Technical Reports Server (NTRS)

    Raup, D. M.; Valentine, J. W.

    1983-01-01

    There is some indication that life may have originated readily under primitive earth conditions. If there were multiple origins of life, the result could have been a polyphyletic biota today. Using simple stochastic models for diversification and extinction, we conclude: (1) the probability of survival of life is low unless there are multiple origins, and (2) given survival of life and given as many as 10 independent origins of life, the odds are that all but one would have gone extinct, yielding the monophyletic biota we have now. The fact of the survival of our particular form of life does not imply that it was unique or superior.

  4. Near Identifiability of Dynamical Systems

    NASA Technical Reports Server (NTRS)

    Hadaegh, F. Y.; Bekey, G. A.

    1987-01-01

    Concepts regarding approximate mathematical models treated rigorously. Paper presents new results in analysis of structural identifiability, equivalence, and near equivalence between mathematical models and physical processes they represent. Helps establish rigorous mathematical basis for concepts related to structural identifiability and equivalence revealing fundamental requirements, tacit assumptions, and sources of error. "Structural identifiability," as used by workers in this field, loosely translates as meaning ability to specify unique mathematical model and set of model parameters that accurately predict behavior of corresponding physical system.

  5. The Adult Life Spiral: A Critique of the Life Cycle Model.

    ERIC Educational Resources Information Center

    Stein, Peter; Etzkowitz, Henry

    We can identify and describe alternate paths of adulthood utilizing data from interviews with single adults. Our review of major models used in adulthood studies suggests that a developmental model, such as Daniel Levinson's life cycle model, is too tied to the notion of the imminent unfolding of the life course. The age-stratification theory…

  6. Quality of Life of Students with Disabilites Attending Jordanian Universities

    ERIC Educational Resources Information Center

    Al-Zboon, Eman; Ahmad, Jamal Fathi; Theeb, Raied Sheikh

    2014-01-01

    In spite of increasing number of students with disabilities in universities, there is limited research on quality of life of these students. This study aimed to identify the quality of life level of undergraduate students with disabilities at Jordanian universities. The sample consisted of (147) students. A quality of life scale was constructed,…

  7. Deciphering life history transcriptomes in different environments

    PubMed Central

    Etges, William J.; Trotter, Meredith V.; de Oliveira, Cássia C.; Rajpurohit, Subhash; Gibbs, Allen G.; Tuljapurkar, Shripad

    2014-01-01

    We compared whole transcriptome variation in six preadult stages and seven adult female ages in two populations of cactophilic Drosophila mojavensis reared on two host plants in order to understand how differences in gene expression influence standing life history variation. We used Singular Value Decomposition (SVD) to identify dominant trajectories of life cycle gene expression variation, performed pair-wise comparisons of stage and age differences in gene expression across the life cycle, identified when genes exhibited maximum levels of life cycle gene expression, and assessed population and host cactus effects on gene expression. Life cycle SVD analysis returned four significant components of transcriptional variation, revealing functional enrichment of genes responsible for growth, metabolic function, sensory perception, neural function, translation and aging. Host cactus effects on female gene expression revealed population and stage specific differences, including significant host plant effects on larval metabolism and development, as well as adult neurotransmitter binding and courtship behavior gene expression levels. In 3 - 6 day old virgin females, significant up-regulation of genes associated with meiosis and oogenesis was accompanied by down-regulation of genes associated with somatic maintenance, evidence for a life history tradeoff. The transcriptome of D. mojavensis reared in natural environments throughout its life cycle revealed core developmental transitions and genome wide influences on life history variation in natural populations. PMID:25442828

  8. Breastfeeding and Everyday Life

    MedlinePlus

    ... Breastfeeding and everyday life More breastfeeding topics ); } Breastfeeding Breastfeeding and everyday life Most breastfeeding moms do not ... support to help women breastfeed successfully. Subscribe to breastfeeding email updates Email Accessibility | Privacy policy | Disclaimers | FOIA | ...

  9. Donate Life America

    MedlinePlus

    ... Us News You Have the Power to Donate Life. Register as an Organ, Eye and Tissue Donor ... reach 30K milestone, thanks to increased donations Donate Life America Announces 2015 James S. Wolf, M.D., Courage ...

  10. End of Life Care

    MedlinePlus

    ... impossible. In such a situation, treatment that only prolongs life may be appropriately withheld. In fact, the ... residents is to relieve discomfort rather than to prolong life. If individuals or their surrogates turn down ...

  11. Live Your Life Well

    MedlinePlus

    ... about reasonable steps that if used consistently can increase your comfort and boost your ability to build a rewarding life. About the Live Your Life Well Campaign Mental Health America is the country's leading non-profit ...

  12. Life Among the Stars

    ERIC Educational Resources Information Center

    MOSAIC, 1977

    1977-01-01

    Explores possibility of extra-terrestrial life, reviewing current hypotheses regarding where in space life would most likely occur. Discusses astrometry and spectroscopy as methods for determining stellar motions. Describes United States and Soviet projects for receiving stellar communications. Relates origin of life on earth to observed high…

  13. Life Skills Project

    ERIC Educational Resources Information Center

    Bates, Jan P.

    2005-01-01

    In this article, Bates, the Inmate Programs Manager of the Hillsborough County Sheriff's Office in Tampa, Florida, describes her office's Life Skills Project, a comprehensive program that has significantly enhanced three existing programs by adding extensive life skills components. The added life skills modules reinforce the importance of…

  14. Chinese Student Life.

    ERIC Educational Resources Information Center

    Braswell, James; Boone, Jerry N.

    1991-01-01

    Places life of university students in China in context of Tiananmen Square and Cultural Revolution, with implications of serving them as students in the United States. Presents basic facts of student life in China. Although the emphasis is on college life, some attention is paid to earlier student experiences as well. (Author/NB)

  15. Family Life Education Transparencies.

    ERIC Educational Resources Information Center

    Clemson Univ., SC. Vocational Education Media Center.

    This compilation of thirty-three transparencies, a supplement to the family life education curriculum guide (see related note), is designed for use by secondary education home economics teachers in teaching family life education classes. The transparencies, covering three areas in family life education, each consist of a captioned picture…

  16. HIV Life Cycle

    MedlinePlus

    HIV Overview The HIV Life Cycle (Last updated 9/8/2016; last reviewed 9/8/2016) Key Points HIV gradually destroys the immune ... life cycle. What is the connection between the HIV life cycle and HIV medicines? Antiretroviral therapy (ART) ...

  17. Advanced Life Support

    NASA Technical Reports Server (NTRS)

    Chambliss, Joe

    2004-01-01

    Viewgraphs on Advanced Life Support (ALS) Systems are presented. The topics include: 1) Fundamental Need for Advanced Life Support; 2) ALS organization; 3) Requirements and Rationale; 4) Past Integrated tests; 5) The need for improvements in life support systems; 6) ALS approach to meet exploration goals; 7) ALS Projects showing promise to meet exploration goals; and 9) GRC involvement in ALS.

  18. End of Life Issues

    MedlinePlus

    Planning for the end of life can be difficult. But by deciding what end-of-life care best suits your needs when you are healthy, you can ... right choices when the time comes. End-of-life planning usually includes making choices about the following: ...

  19. Family Life Education Needs of Mentally Disabled Adolescents.

    ERIC Educational Resources Information Center

    Schultz, Jerelyn B.; Adams, Donna U.

    1987-01-01

    Administered 50 needs statements to 134 minimally and mildly mentally disabled adolescent students to identify their family life education needs as a basis for curriculum development. Identified six clusters or groups of family life education needs: Basic Nutrition, Teenage Pregnancy, Sex Education, Developmental Tasks of Adolescents, Marriage and…

  20. Planets Suitable for Life

    NASA Astrophysics Data System (ADS)

    Peter, Ulmschneider

    When searching for extraterrestrial life, and particularly intelligent life, elsewhere in the solar system or in our galaxy, the obvious places to look are habitable Earth-like planets. This is because most living organisms are quite vulnerable to harsh conditions, and thus the presence of life will be most likely when very favorable conditions occur. Here organisms that survive under extreme conditions on Earth represent no contradiction, because they have adapted to their way of life by the fierce battle of survival on the basis of Darwin's theory (discussed in Chap. 6). But what are the conditions that are favorable for life?

  1. Identifying Clients Predisposed To Failure

    ERIC Educational Resources Information Center

    Carnes, G. D.

    1973-01-01

    Studies are reviewed that report the prediction of rehabilitation failure from personality measures. Related research is discussed that suggest the dynamics underlying a key concept, the "hypochondriacally organized personality" which is identifiable from the Rorschach anatomy response percentage. (Author)

  2. Identifying Occupationally Specific Affective Behaviors.

    ERIC Educational Resources Information Center

    Pucel, David J.

    1993-01-01

    Data from two groups of cosmetology instructors (n=15) and two groups of machinist instructors (n=17) validated the Occupational Affective Behavior Analysis instrument as capable of identifying affective behaviors viewed as important to success in a given occupation. (SK)

  3. Identifying Obstacles to Incorporating Ocean Content into California Secondary Classrooms

    ERIC Educational Resources Information Center

    Stock, Jennifer

    2010-01-01

    The ocean is the dominant feature on this planet that makes all life on Earth possible. Marine educators and scientists across the country have identified essential principles and concepts that define what an "ocean literate" person should know, but there is a lack of comprehensive ocean content coverage in secondary classrooms across the United…

  4. What Is Life? What Was Life? What Will Life Be?

    NASA Astrophysics Data System (ADS)

    Deamer, D.

    Our laboratory is exploring self-assembly processes and polymerization reactions of organic compounds in natural geothermal environments and related laboratory simulations. Although the physical environment that fostered primitive cellular life is still largely unconstrained, we can be reasonably confident that liquid water was required, together with a source of organic compounds and energy to drive polymerization reactions. There must also have been a process by which the compounds were sufficiently concentrated to undergo physical and chemical interactions. In earlier work we observed that macromolecules such as nucleic acids and proteins are readily encapsulated in membranous boundaries during wet-dry cycles such as those that would occur at the edges of geothermal springs or tide pools. The resulting structures are referred to as protocells, in that they exhibit certain properties of living cells and are models of the kinds of encapsulated macromolecular systems that would have led toward the first forms of cellular life. However, the assembly of protocells is markedly inhibited by conditions associated with extreme environments: High temperature, high salt concentrations, and low pH ranges. From a biophysical perspective, it follows that the most plausible planetary environment for the origin of cellular life would be an aqueous phase at moderate temperature ranges and low ionic strength, having a pH value near neutrality and divalent cations at submillimolar concentrations. This suggestion is in marked contrast to the view that life most likely began in a geothermal or marine environment, perhaps even the extreme environment of a hydrothermal vent. A more plausible site for the origin of cellular life would be fresh water pools maintained by rain falling on volcanic land masses resembling present-day Hawaii and Iceland. After the first cellular life was able to establish itself in a relatively benign environment, it would rapidly begin to adapt through

  5. A life course approach to cardiovascular aging

    PubMed Central

    Hardy, Rebecca; Lawlor, Debbie A; Kuh, Diana

    2015-01-01

    A life course approach in epidemiology investigates the biological, behavioral and social pathways that link physical and social exposures and experiences during gestation, childhood, adolescence and adult life, and across generations, to later-life health and disease risk. We illustrate how a life course approach has been applied to cardiovascular disease, highlighting the evidence in support of the early origins of disease risk. We summarize how trajectories of cardiometabolic risk factors change over the life course and suggest that understanding underlying ‘normal’ or ‘healthy’ trajectories and the characteristics that drive deviations from such trajectories offer the potential for early prevention and for identifying means of preventing future disease. PMID:25606706

  6. Life on Jupiter. [terrestrial type life possibilities

    NASA Technical Reports Server (NTRS)

    Libby, W. F.

    1974-01-01

    The possibilities of life on Jupiter are discussed from the point view of life as known on earth. That is, it is assumed that any life on Jupiter would not involve new principles foreign to us. Proteins would be a constituent as would fats and the other building blocks of living organisms on earth. This leads to a set of limiting parameters, such as pressure. Studies in the laboratory have shown that proteins and other essential molecules are denatured by pressures of 4000 atm and higher. Thus, life cannot be expected to exist in the great depths of the Jovian atmosphere. It could exist only at depths of several hundred kilometers in the atmosphere. Since no solid surface could possibly exist at such altitudes, any organisms present must be small enough to be buoyed up by the turbulent atmospheric currents or must fly or both. Such possibilities, however, seem to be real. The necessary nutrients to preserve life and foster growth could be furnished by the Miller-Urey type reactions of ionizing radiation on the reducing atmosphere undoubtedly present.

  7. Identifying foot fractures and dislocations.

    PubMed

    Caswell, Fiona; Brown, Craig

    2014-10-01

    As the roles of emergency nurse practitioners expand, more patients with minor injuries are being managed independently by nursing staff. Injuries to the foot and ankle are common among such patients, and X-rays are frequently performed to aid their diagnoses. Some of these fractures and dislocations are subtle and difficult to identify, so practitioners must adopt a structured approach to reading X-rays. This article describes some of these injuries and offers advice, including X-ray illustrations, on how to identify them. PMID:25270819

  8. Life in Extreme Environments

    NASA Technical Reports Server (NTRS)

    McKay, Christopher P.; Young, Richard E. (Technical Monitor)

    1997-01-01

    Although the Viking results may indicate that Mars has no life today, there is direct geomorphological evidence that, in the past, Mars had large amounts of liquid water on its surface - possibly due to a thicker atmosphere. From a biological perspective the existence of liquid water, by itself motivates the question of the origin of life on Mars. One of the martian meteorites dates back to this early period and may contain evidence consistent with life. From studies of the Earth's earliest biosphere we know that by 3.5 Gyr. ago, life had originated on Earth and reached a fair degree of biological sophistication. Surface activity and erosion on Earth make it difficult to trace the history of life before the 3.5 Gyr timeframe. Ecosystems in cold, dry locations on Earth - such as the Antarctic - provide examples of how life on Mars might have survived and where to look for fossils.

  9. DNA Barcoding Identifies Illegal Parrot Trade.

    PubMed

    Gonçalves, Priscila F M; Oliveira-Marques, Adriana R; Matsumoto, Tania E; Miyaki, Cristina Y

    2015-01-01

    Illegal trade threatens the survival of many wild species, and molecular forensics can shed light on various questions raised during the investigation of cases of illegal trade. Among these questions is the identity of the species involved. Here we report a case of a man who was caught in a Brazilian airport trying to travel with 58 avian eggs. He claimed they were quail eggs, but authorities suspected they were from parrots. The embryos never hatched and it was not possible to identify them based on morphology. As 29% of parrot species are endangered, the identity of the species involved was important to establish a stronger criminal case. Thus, we identified the embryos' species based on the analyses of mitochondrial DNA sequences (cytochrome c oxidase subunit I gene [COI] and 16S ribosomal DNA). Embryonic COI sequences were compared with those deposited in BOLD (The Barcode of Life Data System) while their 16S sequences were compared with GenBank sequences. Clustering analysis based on neighbor-joining was also performed using parrot COI and 16S sequences deposited in BOLD and GenBank. The results, based on both genes, indicated that 57 embryos were parrots (Alipiopsitta xanthops, Ara ararauna, and the [Amazona aestiva/A. ochrocephala] complex), and 1 was an owl. This kind of data can help criminal investigations and to design species-specific anti-poaching strategies, and demonstrate how DNA sequence analysis in the identification of bird species is a powerful conservation tool. PMID:26245790

  10. Early Life Exposures and Cancer

    Cancer.gov

    Early-life events and exposures have important consequences for cancer development later in life, however, epidemiological studies of early-life factors and cancer development later in life have had significant methodological challenges.

  11. Identifying Vocational Education and Training.

    ERIC Educational Resources Information Center

    Moodie, Gavin

    2002-01-01

    Definitions of vocational education may be classified as epistemological, teleological, hierarchical, or pragmatic. No single classification is adequate to identify it across location and time. A definition should be a composite of the four categories: the development and application of knowledge and skills for middle-level occupations needed by…

  12. Identifying Plant Poisoning in Livestock

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Poisonous plant intoxication is a common and often deadly problem that annually costs the livestock industry more than $340 million in the western United States alone. Despite the cost or frequency, definitively identifying or diagnosing poisoning by plants in livestock is challenging. The purpos...

  13. Identifying Potential Dropouts. ERIC Digest.

    ERIC Educational Resources Information Center

    Gaustad, Joan

    An overview of issues and problems in identifying and predicting dropouts is presented in this Digest. The topics discussed are as follows: factors associated with dropping out; defining and calculating dropouts; problems in prediction; the usefulness of current prediction models; and suggestions for improving prediction. The recommendation is…

  14. Identifying, Assisting the Disturbed Adolescent.

    ERIC Educational Resources Information Center

    Carlson, Patricia L.; Schaefer, William

    1986-01-01

    Educators are in an excellent position to identify seriously troubled young people. Major causes of adolescent problems are discussed, including drugs, parental failure, and biochemical disturbances. Educators can best intervene by becoming aware of support services within their own school and community. (TE)

  15. Identifying the Gifted Child Humorist.

    ERIC Educational Resources Information Center

    Fern, Tami L.

    1991-01-01

    This study attempted to identify gifted child humorists among 1,204 children in grades 3-6. Final identification of 13 gifted child humorists was determined through application of such criteria as funniness, originality, and exemplary performance or product. The influence of intelligence, development, social factors, sex differences, family…

  16. Chemistry in Second Life

    PubMed Central

    Lang, Andrew SID; Bradley, Jean-Claude

    2009-01-01

    This review will focus on the current level on chemistry research, education, and visualization possible within the multi-user virtual environment of Second Life. We discuss how Second Life has been used as a platform for the interactive and collaborative visualization of data from molecules and proteins to spectra and experimental data. We then review how these visualizations can be scripted for immersive educational activities and real-life collaborative research. We also discuss the benefits of the social networking affordances of Second Life for both chemists and chemistry students. PMID:19852781

  17. Shuttle extravehicular life support equipment

    NASA Technical Reports Server (NTRS)

    Sutton, J. G.

    1973-01-01

    A Shuttle EVA/IVA Requirements Study was conducted by Hamilton Standard for NASA. The objectives of this study were to establish a baseline EVA approach for Shuttle and to prepare requirements for the EVA equipment required to support these operations. This paper presents the results of the EVA life support requirements definition effort and defines candidate configurations which meet these requirements. Various subsystem and system concepts were identified and evaluated to determine the most desirable approaches. Both independent and umbilical configurations are considered. Because certain EVA missions could involve contamination-sensitive payloads, the impact of integrating noncontaminating equipment is also considered.

  18. WOWBugs: New Life for Life Science.

    ERIC Educational Resources Information Center

    Matthews, Robert W.; And Others

    This book of life science activities introduces a new experimental animal--the WOWBug, "Melittobia digitata"--that is commonly found in nature but has never before been used in the precollege classroom. It includes 20 activities and experiments for grades 5-12, that cover topics from basic orientation to ecological interactions, from physical…

  19. Identifying the Best Treatment Among Common Nonsurgical Neck Pain Treatments

    PubMed Central

    Hogg-Johnson, Sheilah; Bayoumi, Ahmed M.; Cassidy, J. David; Côté, Pierre; Boyle, Eleanor; Llewellyn-Thomas, Hilary; Chan, Stella; Subrata, Peter; Hoving, Jan Lucas; Hurwitz, Eric; Bombardier, Claire; Krahn, Murray

    2008-01-01

    Study Design Decision analysis. Objective To identify the best treatment for nonspecific neck pain. Summary of Background Data In Canada and the United States, the most commonly prescribed neck pain treatments are nonsteroidal anti-inflammatory drugs (NSAIDs), exercise, and manual therapy. Deciding which treatment is best is difficult because of the trade-offs between beneficial and harmful effects, and because of the uncertainty of these effects. Methods (Quality-adjusted) life expectancy associated with standard NSAIDs, Cox-2 NSAIDs, exercise, mobilization, and manipulation were compared in a decision-analytic model. Estimates of the course of neck pain, background risk of adverse events in the general population, treatment effectiveness and risk, and patient-preferences were input into the model. Assuming equal effectiveness, we conducted a baseline analysis using risk of harm only. We assessed the stability of the baseline results by conducting a second analysis that incorporated effectiveness data from a high-quality randomized trial. Results There were no important differences across treatments. The difference between the highest and lowest ranked treatments predicted by the baseline model was 4.5 days of life expectancy and 3.4 quality-adjusted life-days. The difference between the highest and lowest ranked treatments predicted by the second model was 7.3 quality-adjusted life-days. Conclusion When the objective is to maximize life expectancy and quality-adjusted life expectancy, none of the treatments in our analysis were clearly superior.

  20. Life at the end of life: beliefs about individual life after death and "good death" models - a qualitative study

    PubMed Central

    Toscani, Franco; Borreani, Claudia; Boeri, Paolo; Miccinesi, Guido

    2003-01-01

    Background Different ideas of "good death" may influence the effectiveness of end-of-life care in patients with different ethos. This study aimed to identify the influence of believing in individual life after death on "good death" models. Methods Semi structured-interview to 8 persons, 4 believers and 4 non-believers in individual life after death from the general Italian population. Analysis of the transcribed text according to the method suggested by Mc Cracken. Results The analysis has shown a diverse and coherent conceptualization of death according to whether the subjects believe or not in individual life after death. Believers, for whom death marks the passage to a new dimension, prefer to be unaware of dying, while non-believers, for whom death is the end of the individual, prefer to be conscious until the very end of life. However some important aspects in common have been identified, i.e. having close people nearby, receiving assistance from experts, or the preference for a soft atmosphere around the dying person. Conclusion There are aspects in common and aspects in contrast between believers and non-believers in individual life after death: while sharing many aspects of what a "good death" ought to be, they have opposite stands on being aware of dying. A plurality of models should be foreseen, accepting, in this case, their practical and theoretical implications. PMID:14613557

  1. Hominin life history: reconstruction and evolution.

    PubMed

    Robson, Shannen L; Wood, Bernard

    2008-04-01

    In this review we attempt to reconstruct the evolutionary history of hominin life history from extant and fossil evidence. We utilize demographic life history theory and distinguish life history variables, traits such as weaning, age at sexual maturity, and life span, from life history-related variables such as body mass, brain growth, and dental development. The latter are either linked with, or can be used to make inferences about, life history, thus providing an opportunity for estimating life history parameters in fossil taxa. We compare the life history variables of modern great apes and identify traits that are likely to be shared by the last common ancestor of Pan-Homo and those likely to be derived in hominins. All great apes exhibit slow life histories and we infer this to be true of the last common ancestor of Pan-Homo and the stem hominin. Modern human life histories are even slower, exhibiting distinctively long post-menopausal life spans and later ages at maturity, pointing to a reduction in adult mortality since the Pan-Homo split. We suggest that lower adult mortality, distinctively short interbirth intervals, and early weaning characteristic of modern humans are derived features resulting from cooperative breeding. We evaluate the fidelity of three life history-related variables, body mass, brain growth and dental development, with the life history parameters of living great apes. We found that body mass is the best predictor of great ape life history events. Brain growth trajectories and dental development and eruption are weakly related proxies and inferences from them should be made with caution. We evaluate the evidence of life history-related variables available for extinct species and find that prior to the transitional hominins there is no evidence of any hominin taxon possessing a body size, brain size or aspects of dental development much different from what we assume to be the primitive life history pattern for the Pan-Homo clade. Data for

  2. Hominin life history: reconstruction and evolution

    PubMed Central

    Robson, Shannen L; Wood, Bernard

    2008-01-01

    In this review we attempt to reconstruct the evolutionary history of hominin life history from extant and fossil evidence. We utilize demographic life history theory and distinguish life history variables, traits such as weaning, age at sexual maturity, and life span, from life history-related variables such as body mass, brain growth, and dental development. The latter are either linked with, or can be used to make inferences about, life history, thus providing an opportunity for estimating life history parameters in fossil taxa. We compare the life history variables of modern great apes and identify traits that are likely to be shared by the last common ancestor of Pan-Homo and those likely to be derived in hominins. All great apes exhibit slow life histories and we infer this to be true of the last common ancestor of Pan-Homo and the stem hominin. Modern human life histories are even slower, exhibiting distinctively long post-menopausal life spans and later ages at maturity, pointing to a reduction in adult mortality since the Pan-Homo split. We suggest that lower adult mortality, distinctively short interbirth intervals, and early weaning characteristic of modern humans are derived features resulting from cooperative breeding. We evaluate the fidelity of three life history-related variables, body mass, brain growth and dental development, with the life history parameters of living great apes. We found that body mass is the best predictor of great ape life history events. Brain growth trajectories and dental development and eruption are weakly related proxies and inferences from them should be made with caution. We evaluate the evidence of life history-related variables available for extinct species and find that prior to the transitional hominins there is no evidence of any hominin taxon possessing a body size, brain size or aspects of dental development much different from what we assume to be the primitive life history pattern for the Pan-Homo clade. Data for

  3. Charting Ingredients for Life

    NASA Technical Reports Server (NTRS)

    2005-01-01

    [figure removed for brevity, see original site] Figure 1: Spectrum Charts Light from a Faraway Galaxy

    This graph, or spectrum, charts light from a faraway galaxy located 10 billion light years from Earth. It tracks mid-infrared light from an extremely luminous galaxy when the universe was only 1/4 of its current age.

    Spectra are created when an instrument called a spectrograph spreads light out into its basic parts, like a prism turning sunlight into a rainbow. They reveal the signatures, or 'fingerprints,' of molecules that make up a galaxy and contribute to its light.

    Spitzer's infrared spectrometer identified characteristic fingerprints of complex organic molecules called polycyclic aromatic hydrocarbons, illustrated in the artist's concept in the inset. These large molecules comprised of carbon and hydrogen, are considered among the building blocks of life.

    Scientists determined it took 10 billion years for photons from this galaxy to reach Spitzer's infrared eyes. These complex carbon and hydrogen molecules are from a young galaxy which is undergoing intense star formation, at the time the universe was only 3.5 billion years old.

    These distant galaxies with enormous amounts of gas being converted into young stars are some of the most luminous objects in the sky. Enshrouded by dust, they are only faint, inconspicuous little dots in optical images. They are as bright as 10 trillion suns put together and 10 times brighter than starburst galaxies seen in our local universe.

    This prompts a fascinating question as to what physical process is driving such enormous energy production in these galaxies when the universe is so young.

    These data were taken by Spitzer's infrared spectrograph in August and September 2004.

  4. [Identifying victims of a disaster].

    PubMed

    de Boer, Hans H; Kloosterman, Ate D; de Bruijn, Arie G; Maat, George J R

    2014-01-01

    Identifying the victims of a disaster is important for the next of kin, to issue a death certificate and, if necessary, for forensic investigations. In the Netherlands victims are identified by the Dutch disaster victim identification team, which is part of the national forensic investigation team ('Landelijk Team Forensische Opsporing'). Ante-mortem data are collected during the identification process; these include the victim's specific medical characteristics and the DNA profile of the victim and their family members. The victim's own doctor can play an important role in the ante-mortem investigation because of his or her knowledge of their personal medical details, and of the possible availability of samples for establishing a DNA profile. The ante-mortem data are then compared with post-mortem data. For a definitive identification at least 1 primary identification characteristic has to be established from the physical remains - dermatoglyphics, the DNA profile or the dental status. PMID:25467027

  5. Geometrical scaling for identified particles

    NASA Astrophysics Data System (ADS)

    Praszalowicz, Michal

    2013-12-01

    We show that recently measured transverse momentum spectra of identified particles exhibit geometrical scaling (GS) in scaling variable τ=(( where m=√{m2+pT2}-m. We explore consequences of GS and show that both mid rapidity multiplicity and mean transverse momenta grow as powers of scattering energy. Furthermore, assuming Tsallis-like parametrization of the spectra we calculate the coefficients of this growth. We also show that Tsallis temperature is related to the average saturation scale.

  6. Identifying and managing problem drinkers.

    PubMed Central

    Kahan, M.

    1996-01-01

    Problem drinking is far more common than severe alcohol dependence and is associated with considerable morbidity and health care costs. Whereas patients with alcohol dependence respond best to intensive treatment, one or more brief sessions of physician advice and counseling reduces alcohol consumption among problem drinkers. The two most useful tools to identify problem drinkers are the CAGE and the drinking problem question. PMID:8653034

  7. Planets and Life

    NASA Astrophysics Data System (ADS)

    Sullivan, Woodruff T., III; Baross, John

    2001-12-01

    Astrobiology involves the study of the origin and history of life on Earth, planets and moons where life may have arisen, and the search for extraterrestrial life. It combines the sciences of biology, chemistry, palaeontology, geology, planetary physics and astronomy. This textbook brings together world experts in each of these disciplines to provide the most comprehensive coverage of the field currently available. Topics cover the origin and evolution of life on Earth, the geological, physical and chemical conditions in which life might arise and the detection of extraterrestrial life on other planets and moons. The book also covers the history of our ideas on extraterrestrial life and the origin of life, as well as the ethical, philosophical and educational issues raised by astrobiology. Written to be accessible to students from diverse backgrounds, this text will be welcomed by advanced undergraduates and graduates who are taking astrobiology courses.• Compiled by world experts in their disciplines to create a truly comprehensive book • Accessible to students from a wide range of backgrounds • A welcome addition to this rapidly-growing field

  8. The life instinct.

    PubMed

    Abel-Hirsch, Nicola

    2010-10-01

    In psychoanalytic writing an oversimplified interpretation of Freud's concept of the life and death instincts sometimes colours the presentation. Roughly, there is an implication that the life instinct is 'good' and the death instinct 'bad'. Freud however is clear that: "Neither of these instincts is any less essential than the other; the phenomena of life arise from the concurrent or mutually opposing action of both"(1933b, p. 209). In this paper I look in detail at the characteristics of the life instinct as conceptualized by Freud, and draw on Bion's work 'on linking' to elaborate Freud's view that binding is the life instinct's key characteristic. I suggest that there are pathological forms of both the life and death instinct if defused (separated off) from the other, and I explore a pathological variation of the life instinct in which binding is without the negation, rest, limit or end provided by the 'opposing action' of the death instinct. I consider an instance of the kind that any analyst might meet clinically, in which an inhibited patient experiences severe anxiety that life-giving connections threaten to proliferate indiscriminately and to an overwhelming intensity and size. PMID:20955245

  9. The Critical Life.

    ERIC Educational Resources Information Center

    Pelias, Ronald J.

    2000-01-01

    Offers an autoethnographic essay which follows one individual throughout his day to explore how evaluation functions as a fundamental orientation of a scholar's academic life. Questions the individual's relationship to criticism and its presence in the ongoing process of doing one's job and of living one's life. (SR)

  10. The Quality of Life

    ERIC Educational Resources Information Center

    Watt, Kenneth E. F.

    1973-01-01

    The origin of our quality of life problems is explained within a historical and international perspective. Two sample problems are analyzed to illustrate the effects of the causes of quality of life problems and to propose solutions to these problems. (KM)

  11. Managing Daily Life

    MedlinePlus

    ... To Cure MD PPMD Merchandise Host an Event Create a Personal Page My Donor Portfolio™ Sponsor Programs Other Ways to Help About Us Mission Financials History Staff & Board Media Awards Partners Contact Us Home / Care for Duchenne / Managing Daily Life Print Email Managing Daily Life Environmental ...

  12. Thermostable Shelf Life Study

    NASA Technical Reports Server (NTRS)

    Perchonok, M. H.; Antonini, D. K.

    2008-01-01

    The objective of this project is to determine the shelf life end-point of various food items by means of actual measurement or mathematical projection. The primary goal of the Advanced Food Technology Project in these long duration exploratory missions is to provide the crew with a palatable, nutritious and safe food system while minimizing volume, mass, and waste. The Mars missions could be as long as 2.5 years with the potential of the food being positioned prior to the crew arrival. Therefore, it is anticipated that foods that are used during the Mars missions will require a 5 year shelf life. Shelf life criteria are safety, nutrition, and acceptability. Any of these criteria can be the limiting factor in determining the food's shelf life. Due to the heat sterilization process used for the thermostabilized food items, safety will be preserved as long as the integrity of the package is maintained. Nutrition and acceptability will change over time. Since the food can be the sole source of nutrition to the crew, a significant loss in nutrition may determine when the shelf life endpoint has occurred. Shelf life can be defined when the food item is no longer acceptable. Acceptability can be defined in terms of appearance, flavor, texture, or aroma. Results from shelf life studies of the thermostabilized food items suggest that the shelf life of the foods range from 0 months to 8 years, depending on formulation.

  13. Life sciences report 1987

    NASA Technical Reports Server (NTRS)

    1987-01-01

    Highlighted here are the major research efforts of the NASA Life Sciences Division during the past year. Topics covered include remote health care delivery in space, space biomedical research, gravitational biology, biospherics (studying planet Earth), the NASA Closed Ecological Life Support System (CELSS), exobiology, flight programs, international cooperation, and education programs.

  14. ICTs and Political Life.

    ERIC Educational Resources Information Center

    Robbin, Alice; Courtright, Christina; Davis, Leah

    2004-01-01

    Presents a literature review that covers the following topics related to information and communications technologies (ICTs): (1) theories of ICTs and how they frame political life; (2) normative democratic theory and concepts; (3) e-political life; and (4) research on e-government, e-governance, and e-democracy; (Contains 276 references.) (MES)

  15. Life Experience Deserves Credit.

    ERIC Educational Resources Information Center

    Snider, John C.; McGee, Leo

    1981-01-01

    Institutions granting credit for life experience are faced with obstacles related to the complex, sensitive, threatening, and ambitious nature of the procedure. A three-step process for implementation of a plan for developing credit for life experiences is provided, along with a dissenting opinion. (MLW)

  16. The Life of Suggestions

    ERIC Educational Resources Information Center

    Pearce, Cathie

    2010-01-01

    Using the notion of a suggestion, or rather charting the life of suggestions, this article considers the happenings of chance and embodiment as the "problems that got away." The life of suggestions helps us to ask how connectivities are made, how desire functions, and how "immanence" rather than "transcendence" can open up the politics and ethics…

  17. Life in the Universe

    ERIC Educational Resources Information Center

    Lowman, Paul D., Jr.

    2003-01-01

    The belief that life exists in the universe is an optimism shared by many. With several manned missions expected to be carried out in the future, the possibility of discovering life in outer space will revolutionize the field of astrobiology. In this article, the author presents a summary of recent developments and discoveries made in the search…

  18. Is Life Unique?

    PubMed Central

    Abel, David L.

    2011-01-01

    Is life physicochemically unique? No. Is life unique? Yes. Life manifests innumerable formalisms that cannot be generated or explained by physicodynamics alone. Life pursues thousands of biofunctional goals, not the least of which is staying alive. Neither physicodynamics, nor evolution, pursue goals. Life is largely directed by linear digital programming and by the Prescriptive Information (PI) instantiated particularly into physicodynamically indeterminate nucleotide sequencing. Epigenomic controls only compound the sophistication of these formalisms. Life employs representationalism through the use of symbol systems. Life manifests autonomy, homeostasis far from equilibrium in the harshest of environments, positive and negative feedback mechanisms, prevention and correction of its own errors, and organization of its components into Sustained Functional Systems (SFS). Chance and necessity—heat agitation and the cause-and-effect determinism of nature’s orderliness—cannot spawn formalisms such as mathematics, language, symbol systems, coding, decoding, logic, organization (not to be confused with mere self-ordering), integration of circuits, computational success, and the pursuit of functionality. All of these characteristics of life are formal, not physical. PMID:25382119

  19. Composing a Research Life

    ERIC Educational Resources Information Center

    Cochran-Smith, Marilyn

    2012-01-01

    In this article about her early career development and the experiences that shaped her life as a scholar and researcher, the author describes the work lives of university-based teacher educators and what it means to compose a research life in this field. This article draws on the author's 30 years as a university-based teacher educator. In it, she…

  20. Thermostabilized Shelf Life Study

    NASA Technical Reports Server (NTRS)

    Perchonok, Michele H.; Catauro, Patricia M.

    2009-01-01

    The objective of this project is to determine the shelf life end-point of various food items by means of actual measurement or mathematical projection. The primary goal of the Advanced Food Technology Project in these long duration exploratory missions is to provide the crew with a palatable, nutritious and safe food system while minimizing volume, mass, and waste. The Mars missions could be as long as 2.5 years with the potential of the food being positioned prior to the crew arrival. Therefore, it is anticipated that foods that are used during the Mars missions will require a 5 year shelf life. Shelf life criteria are safety, nutrition, and acceptability. Any of these criteria can be the limiting factor in determining the food's shelf life. Due to the heat sterilization process used for the thermostabilized food items, safety will be preserved as long as the integrity of the package is maintained. Nutrition and acceptability will change over time. Since the food can be the sole source of nutrition to the crew, a significant loss in nutrition may determine when the shelf life endpoint has occurred. Shelf life can be defined when the food item is no longer acceptable. Acceptability can be defined in terms of appearance, flavor, texture, or aroma. Results from shelf life studies of the thermostabilized food items suggest that the shelf life of the foods range from 0 months to 8 years, depending on formulation.

  1. Family Life Cycle: 1980.

    ERIC Educational Resources Information Center

    Norton, Arthur J.

    1983-01-01

    Used data from a 1980 national sample survey to show differences in the timing of major family life-cycle events according to age, social and economic characteristics, and marital history. Results suggest that age generational differences, more than any other factor, influence timing of life-cycle events. (Author/JAC)

  2. It's a Frog's Life

    ERIC Educational Resources Information Center

    Coffey, Audrey L.; Sterling, Donna R.

    2003-01-01

    When a preschool teacher unexpectedly found tadpoles in the school's outdoor baby pool, she recognized an unusual opportunity for her students to study pond life up close. By following the tadpoles' development, students learned about frogs, life cycles, habitats. (Contains 1 resource.)

  3. Planets and Life

    NASA Astrophysics Data System (ADS)

    Sullivan, Woodruff T., III; Baross, John

    2007-09-01

    Foreword; Preface; Contributors; Prologue; Part I. History: 1. History of astrobiological ideas W. T. Sullivan and D. Carney; 2. From exobiology to astrobiology S. J. Dick; Part II. The Physical Stage: 3. Formation of Earth-like habitable planets D. E. Brownlee and M. Kress; 4. Planetary atmospheres and life D. Catling and J. F. Kasting; Part III. The Origin of Life on Earth: 5. Does 'life' have a definition? C.E. Cleland and C. F. Chyba; 6. Origin of life: crucial issues R. Shapiro; 7. Origin of proteins and nucleic acids A. Ricardo and S. A. Benner; 8. The roots of metabolism G.D. Cody and J. H. Scott; 9. Origin of cellular life D. W. Deamer; Part IV. Life on Earth: 10. Evolution: a defining feature of life J. A. Baross; 11. Evolution of metabolism and early microbial communities J. A. Leigh, D. A. Stahl and J. T. Staley; 12. The earliest records of life on Earth R. Buick; 13. The origin and diversification of eukaryotes M. L. Sogin, D. J. Patterson and A. McArthur; 14. Limits of carbon life on Earth and elsewhere J. A. Baross, J. Huber and M. Schrenk; 15. Life in ice J. W. Deming and H. Eicken; 16. The evolution and diversification of life S. Awramik and K. J. McNamara; 17. Mass extinctions P. D. Ward; Part V. Potentially Habitable Worlds: 18. Mars B. M. Jakosky, F. Westall and A. Brack; 19. Europa C. F. Chyba and C. B. Phillips; 20. Titan J. I. Lunine and B. Rizk; 21. Extrasolar planets P. Butler; Part VI. Searching for Extraterrestrial Life: 22. How to search for life on other worlds C. P. McKay; 23. Instruments and strategies for detecting extraterrestrial life P. G. Conrad; 24. Societial and ethical concerns M. S. Race; 25. Planetary protection J. D. Rummel; 26. Searching for extraterrestrial intelligence J. C. Tarter; 27. Alien biochemistries P. D. Ward and S. A. Benner; Part VII. Future of the Field: 28. Disciplinary and educational opportunities L. Wells, J. Armstrong and J. Huber; Epilogue C. F. Chyba; Appendixes: A. Units and usages; B. Planetary

  4. Life in Extreme Environments

    NASA Technical Reports Server (NTRS)

    Rothschild, Lynn; Bray, James A. (Technical Monitor)

    2002-01-01

    Each recent report of liquid water existing elsewhere in the solar system has reverberated through the international press and excited the imagination of humankind. Why? Because in the last few decades we have come to realize that where there is liquid water on Earth, virtually no matter what the physical conditions, there is life. What we previously thought of as insurmountable physical and chemical barriers to life, we now see as yet another niche harboring 'extremophiles'. This realization, coupled with new data on the survival of microbes in the space environment and modeling of the potential for transfer of life between celestial bodies, suggests that life could be more common than previously thought. Here we critically examine what it means to be an extremophile, the implications of this for evolution, biotechnology, and especially the search for life in the cosmos.

  5. Origin of Life

    NASA Astrophysics Data System (ADS)

    Lal, Ashwini Kumar

    2008-10-01

    The evolution of life has been a big enigma despite rapid advancements in the field of astrobiology, microbiology and genetics in recent years. The answer to this puzzle is as mindboggling as the riddle relating to evolution of the universe itself. Despite the fact that panspermia has gained considerable support as a viable explanation for origin of life on the earth and elsewhere in the universe, the issue, however, remains far from a tangible solution. This paper examines the various prevailing hypotheses regarding origin of life-like abiogenesis, RNA world, iron-sulphur world and panspermia, and concludes that delivery of life-bearing organic molecules by the comets in the early epoch of the earth alone possibly was not responsible for kick-starting the process of evolution of life on our planet.

  6. Emergence of Life.

    PubMed

    Bassez, Marie-Paule

    2011-01-01

    Indeed, even if we know that many individual components are necessary for life to exist, we do not yet know what makes life emerge. One goal of this journal Life is to juxtapose articles with multidisciplinary approaches and perhaps to answer in the near future this question of the emergence of life. Different subjects and themes will be developed, starting of course with the multiple definitions of life and continuing with others such as: life diversity and universality; characteristics of living systems; thermodynamics with energy and entropy; kinetics and catalysis; water in its different physical states; circulation of sap and blood and its origin; the first blood pump and first heart; the first exchange of nutrients between cells, sap and blood; essential molecules of living systems; chirality; molecular asymmetry and its origin; formation of enantiomer excess and amplification; microscopic observations on a micrometer and sub-micrometer scales, at molecular and atomic levels; the first molecules at the origin of genetic information, viroids, circular RNA; regions of space or the area inside membranes and cells capable of initiating and maintaining life; phenomena at the origin of the emergence of life; molecules studied in the traditional field of chemistry and in the recent field of nanoscience governed by new laws; interaction between the individual molecules and components of living systems; interaction between living systems and the environment; transfer of information through generations; continuation of life from one generation to the next; prebiotic chemistry and prebiotic signatures on Earth, on Mars, on other planets; biosignatures of the first forms of life; fossils and pseudofossils dating 3.5 Ga ago and more recent ones; experimental fossilization; pluricellular eukaryotes dating 2.1 Ga ago; sudden increase in oxygen in the atmosphere around 2.0 to 2.5 Ga ago and its relation to geology; shell symmetry; aging with transformation of molecules, of

  7. Persistent Identifiers for Dutch cultural heritage institutions

    NASA Astrophysics Data System (ADS)

    Ras, Marcel; Kruithof, Gijsbert

    2016-04-01

    Over the past years, more and more collections belonging to archives, libraries, media, museums, and knowledge institutes are being digitised and made available online. These are exciting times for ALM institutions. They are realising that, in the information society, their collections are goldmines. Unfortunately most heritage institutions in the Netherlands do not yet meet the basic preconditions for long-term availability of their collections. The digital objects often have no long lasting fixed reference yet. URL's and web addresses change. Some digital objects that were referenced in Europeana and other portals can no longer be found. References in scientific articles have a very short life span, which is damaging for scholarly research. In 2015, the Dutch Digital Heritage Network (NDE) has started a two-year work program to co-ordinate existing initiatives in order to improve the (long-term) accessibility of the Dutch digital heritage for a wide range of users, anytime, anyplace. The Digital Heritage Network is a partnership established on the initiative of the Ministry of Education, Culture and Science. The members of the NDE are large, national institutions that strive to professionally preserve and manage digital data, e.g. the National Library, The Netherlands Institute for Sound and Vision, the Netherlands Cultural Heritage Agency, the Royal Netherlands Academy of Arts and Sciences, the National Archive of the Netherlands and the DEN Foundation, and a growing number of associations and individuals both within and outside the heritage sector. By means of three work programmes the goals of the Network should be accomplished and improve the visibility, the usability and the sustainability of digital heritage. Each programme contains of a set of projects. Within the sustainability program a project on creating a model for persistent identifiers is taking place. The main goals of the project are (1) raise awareness among cultural heritage institutions on the

  8. Life Satisfaction and Frequency of Doctor Visits

    PubMed Central

    Kim, Eric S.; Park, Nansook; Sun, Jennifer K.; Smith, Jacqui; Peterson, Christopher

    2015-01-01

    Objective Identifying positive psychological factors that reduce health care use may lead to innovative efforts that help build a more sustainable and high quality health care system. Prospective studies indicate that life satisfaction is associated with good health behaviors, enhanced health, and longer life, but little information is available about the association between life satisfaction and health care use. We tested whether higher life satisfaction was prospectively associated with fewer doctor visits. We also examined potential interactions between life satisfaction and health behaviors. Methods Participants were 6,379 adults from the Health and Retirement Study, a prospective and nationally representative panel study of American adults over the age of 50. Participants were tracked for four years. We analyzed the data using a generalized linear model with a gamma distribution and log link. Results Higher life satisfaction was associated with fewer doctor visits. On a six-point life satisfaction scale, each unit increase in life satisfaction was associated with an 11% decrease in doctor visits—after adjusting for sociodemographic factors (RR = 0.89, 95% CI = 0.86 to 0.93). The most satisfied respondents (N=1,121; 17.58%) made 44% fewer doctor visits than the least satisfied (N=182; 2.85%). The association between higher life satisfaction and reduced doctor visits remained even after adjusting for baseline health and a wide range of sociodemographic, psychosocial, and health-related covariates (RR = 0.96, 95% CI = 0.93 to 0.99). Conclusions Higher life satisfaction is associated with fewer doctor visits, which may have important implications for reducing health care costs. PMID:24336427

  9. Life on Titan

    NASA Astrophysics Data System (ADS)

    Potashko, Oleksandr

    Volcanoes engender life on heavenly bodies; they are pacemakers of life. All planets during their period of formation pass through volcanism hence - all planets and their satellites pass through the life. Tracks of life If we want to find tracks of life - most promising places are places with volcanic activity, current or past. In the case of just-in-time volcanic activity we have 100% probability to find a life. Therefore the most perspective “search for life” are Enceladus, Io and comets, further would be Venus, Jupiter’s satellites, Saturn’s satellites and first of all - Titan. Titan has atmosphere. It might be result of high volcanic activity - from one side, from other side atmosphere is a necessary condition development life from procaryota to eucaryota. Existence of a planet means that all its elements after hydrogen formed just there inside a planet. The forming of the elements leads to the formation of mineral and organic substances and further to the organic life. Development of the life depends upon many factors, e.g. the distance from star/s. The intensity of the processes of the element formation is inversely to the distance from the star. Therefore we may suppose that the intensity of the life in Mercury was very high. Hence we may detect tracks of life in Mercury, particularly near volcanoes. The distance from the star is only one parameter and now Titan looks very active - mainly due to interior reason. Its atmosphere compounds are analogous to comet tail compounds. Their collation may lead to interesting result as progress occurs at one of them. Volcanic activity is as a source of life origin as well a reason for a death of life. It depends upon the thickness of planet crust. In the case of small thickness of a crust the probability is high that volcanoes may destroy a life on a planet - like Noachian deluge. Destroying of the life under volcano influences doesn’t lead to full dead. As result we would have periodic Noachian deluge or

  10. Defining Life or Bringing Biology to Life

    NASA Astrophysics Data System (ADS)

    Ruiz-Mirazo, Kepa; Peretó, Juli; Moreno, Alvaro

    2010-04-01

    In the present, post-genomic times, systemic or holistic approaches to living phenomena are compulsory to overcome the limits of traditional strategies, such as the methodological reductionism of molecular biology. In this paper, we propose that theoretical and philosophical efforts to define life also contribute to those integrative approaches, providing a global theoretical framework that may help to deal with or interpret the huge amount of data being collected by current high-throughput technologies, in this so-called ‘omics’ revolution. We claim that two fundamental notions can capture the core of the living, (basic) autonomy and open-ended evolution, and that only the complementary combination of these two theoretical constructs offers an adequate solution to the problem of defining the nature of life in specific enough—but also encompassing enough—terms. This tentative solution should also illuminate, in its most elementary version, the leading steps towards living beings on Earth.

  11. Defining life or bringing biology to life.

    PubMed

    Ruiz-Mirazo, Kepa; Peretó, Juli; Moreno, Alvaro

    2010-04-01

    In the present, post-genomic times, systemic or holistic approaches to living phenomena are compulsory to overcome the limits of traditional strategies, such as the methodological reductionism of molecular biology. In this paper, we propose that theoretical and philosophical efforts to define life also contribute to those integrative approaches, providing a global theoretical framework that may help to deal with or interpret the huge amount of data being collected by current high-throughput technologies, in this so-called 'omics' revolution. We claim that two fundamental notions can capture the core of the living, (basic) autonomy and open-ended evolution, and that only the complementary combination of these two theoretical constructs offers an adequate solution to the problem of defining the nature of life in specific enough-but also encompassing enough-terms. This tentative solution should also illuminate, in its most elementary version, the leading steps towards living beings on Earth. PMID:20182798

  12. Identifying Network Perturbation in Cancer

    PubMed Central

    Logsdon, Benjamin A.; Gentles, Andrew J.; Lee, Su-In

    2016-01-01

    We present a computational framework, called DISCERN (DIfferential SparsE Regulatory Network), to identify informative topological changes in gene-regulator dependence networks inferred on the basis of mRNA expression datasets within distinct biological states. DISCERN takes two expression datasets as input: an expression dataset of diseased tissues from patients with a disease of interest and another expression dataset from matching normal tissues. DISCERN estimates the extent to which each gene is perturbed—having distinct regulator connectivity in the inferred gene-regulator dependencies between the disease and normal conditions. This approach has distinct advantages over existing methods. First, DISCERN infers conditional dependencies between candidate regulators and genes, where conditional dependence relationships discriminate the evidence for direct interactions from indirect interactions more precisely than pairwise correlation. Second, DISCERN uses a new likelihood-based scoring function to alleviate concerns about accuracy of the specific edges inferred in a particular network. DISCERN identifies perturbed genes more accurately in synthetic data than existing methods to identify perturbed genes between distinct states. In expression datasets from patients with acute myeloid leukemia (AML), breast cancer and lung cancer, genes with high DISCERN scores in each cancer are enriched for known tumor drivers, genes associated with the biological processes known to be important in the disease, and genes associated with patient prognosis, in the respective cancer. Finally, we show that DISCERN can uncover potential mechanisms underlying network perturbation by explaining observed epigenomic activity patterns in cancer and normal tissue types more accurately than alternative methods, based on the available epigenomic data from the ENCODE project. PMID:27145341

  13. Identifying Network Perturbation in Cancer.

    PubMed

    Grechkin, Maxim; Logsdon, Benjamin A; Gentles, Andrew J; Lee, Su-In

    2016-05-01

    We present a computational framework, called DISCERN (DIfferential SparsE Regulatory Network), to identify informative topological changes in gene-regulator dependence networks inferred on the basis of mRNA expression datasets within distinct biological states. DISCERN takes two expression datasets as input: an expression dataset of diseased tissues from patients with a disease of interest and another expression dataset from matching normal tissues. DISCERN estimates the extent to which each gene is perturbed-having distinct regulator connectivity in the inferred gene-regulator dependencies between the disease and normal conditions. This approach has distinct advantages over existing methods. First, DISCERN infers conditional dependencies between candidate regulators and genes, where conditional dependence relationships discriminate the evidence for direct interactions from indirect interactions more precisely than pairwise correlation. Second, DISCERN uses a new likelihood-based scoring function to alleviate concerns about accuracy of the specific edges inferred in a particular network. DISCERN identifies perturbed genes more accurately in synthetic data than existing methods to identify perturbed genes between distinct states. In expression datasets from patients with acute myeloid leukemia (AML), breast cancer and lung cancer, genes with high DISCERN scores in each cancer are enriched for known tumor drivers, genes associated with the biological processes known to be important in the disease, and genes associated with patient prognosis, in the respective cancer. Finally, we show that DISCERN can uncover potential mechanisms underlying network perturbation by explaining observed epigenomic activity patterns in cancer and normal tissue types more accurately than alternative methods, based on the available epigenomic data from the ENCODE project. PMID:27145341

  14. Methods for Identifying Pair Halos

    NASA Astrophysics Data System (ADS)

    Wells, Brendan; Caputo, Regina; Atwood, William; Ritz, Steven M.

    2016-01-01

    The flux of very high energy gamma rays from active galactic nuclei (AGN) is attenuated via interactions with extragalactic background photons and is converted into e+e- pairs. With non-zero intergalactic magnetic fields, the electrons and positrons will deflect as they propagate and simultaneously lose energy by upscattering cosmic microwave background photons. "Pair halos," the visible consequences of these electromagnetic cascades, are faint and difficult to observe against their AGN counterparts. We investigate three methods for indirectly identifying pair halos, using a two-component approach to model the AGN core/halo image. We estimate each method's sensitivity by utilizing a new, detailed Monte Carlo pair-halo simulation.

  15. Work, family and life-course fit

    PubMed Central

    Moen, Phyllis; Kelly, Erin; Huang, Qinlei

    2008-01-01

    This study moves from “work-family” to a multi-dimensional “life-course fit” construct (employees’ cognitive assessments of resources, resource deficits, and resource demands), using a combined work-family, demands-control and ecology of the life course framing. It examined (1) impacts of job and home ecological systems on fit dimensions, and (2) whether control over work time predicted and mediated life-course fit outcomes. Using cluster analysis of survey data on a sample of 917 white-collar employees from Best Buy headquarters, we identified four job ecologies (corresponding to the job demands-job control model) and five home ecologies (theorizing an analogous home demands-home control model). Job and home ecologies predicted fit dimensions in an additive, not interactive, fashion. Employees’ work-time control predicted every life-course fit dimension and partially mediated effects of job ecologies, organizational tenure, and job category. PMID:19430546

  16. Life support systems for Mars transit

    NASA Technical Reports Server (NTRS)

    Macelroy, R. D.; Kliss, M.; Straight, C.

    1992-01-01

    The structural elements of life-support systems are reviewed in order to assess the suitability of specific features for use during a Mars mission. Life-support requirements are estimated by means of an approximate input/output analysis, and the advantages are listed relating to the use of recycling and regeneration techniques. The technological options for regeneration are presented in categories such as CO2 reduction, organics removal, polishing, food production, and organics oxidation. These data form the basis of proposed mission requirements and constraints as well as the definition of what constitutes an adequate reserve. Regenerative physical/chemical life-support systems are championed based exclusively on the mass savings inherent in the technology. The resiliency and 'soft' failure modes of bioregenerative life-support systems are identified as areas of investigation.

  17. USSR Space Life Sciences Digest, issue 13

    NASA Technical Reports Server (NTRS)

    Hooke, Lydia Razran (Editor); Teeter, Ronald (Editor); Teeter, Ronald (Editor); Teeter, Ronald (Editor); Teeter, Ronald (Editor)

    1987-01-01

    This is the thirteenth issue of NASA's USSR Space Life Sciences Digest. It contains abstracts of 39 papers recently published in Russian-language periodicals and bound collections, two papers delivered at an international life sciences symposium, and three new Soviet monographs. Selected abstracts are illustrated with figures and tables from the original. Also included is a review of a recent Soviet-French symposium on Space Cytology. Current Soviet Life Sciences titles available in English are cited. The materials included in this issue have been identified as relevant to 31 areas of aerospace medicine and space biology. These areas are: adaptation, biological rhythms, body fluids, botany, cardiovascular and respiratory systems, cosmonaut training, cytology, developmental biology, endocrinology, enzymology, equipment and instrumentation, gastrointestinal systems, genetics, habitability and environment effects, hematology, human performance, immunology, life support systems, mathematical modeling, metabolism, microbiology, musculoskeletal system, neurophysiology, nutrition, operational medicine, perception, personnel selection, psychology, radiobiology, space biology, and space medicine.

  18. Exploring life's limits: Deep geobiochemistry

    NASA Astrophysics Data System (ADS)

    Cox, A. D.

    2014-12-01

    N-dimensional chemical space on Earth and beyond produces diverse habitats for microbial activity. Hydrothermal environments cover a wide range of habitable space up to and including life's known limits and provide a window into deep geological, geochemical, and biological processes. Hydrothermal water compositions, as sampled from and measured in terrestrial hot springs on Earth's surface, vary in chemical constituent speciation and concentrations over orders of magnitude in a plethora of geochemical parameters with biological significance, including hydronium ion, sulfide, iron, zinc, magnesium, manganese, and molybdenum. Proteins provide a link between geochemistry and microbial activity by catalyzing chemical reactions. Proteins extracted and identified by tandem mass spectrometry from 13 hot spring sediments and biofilms - covering pH values from 2-9 and diverse geochemical compositions - function as efflux transporters, permeases, electron transporters, and others, suggesting that these processes were present in the environment and occurring at the time of sampling. Metalloenzymes have been identified, including the iron protein rubrerythrin, thought to be involved in oxidative stress protection in anaerobic bacteria and archaea, as well as proteins involved in macronutrient processing (carbon, phosphorus, nitrogen, and sulfur). The melding of biochemistry with geochemistry shows potential for quantifying microbial activity in deep environments by demonstrating the presence - and as techniques improve, relative abundances - of reaction-catalyzing enzymes. Moreover, using hot spring sources and their outflow channels as chemical and biological models of geologic time helps decipher the origin and co-evolution of life and geochemistry.

  19. Towards the bibliography of life.

    PubMed

    King, David; Morse, David R; Willis, Alistair; Dil, Anton

    2011-01-01

    This paper discusses how we intend to take forward the vision of a Bibliography of Life in the ViBRANT project. The underlying principle of the Bibliography is to provide taxonomists and others with a freely accessible bibliography covering the whole of life. Such a bibliography has been achieved for specific study areas within taxonomy, but not for "life" as a whole.The creation of such a comprehensive tool has been hindered by various social and technical issues. The social concerns focus on the willingness of users to contribute to the Bibliography. The technical concerns relate to the architecture required to deliver the Bibliography. These issues are discussed in the paper and approaches to addressing them within the ViBRANT project are described, to demonstrate how we can now seriously consider building a Bibliography of Life. We are particularly interested in the potential of the resulting tool to improve the quality of bibliographic references. Through analysing the large number of references in the Bibliography we will be able to add metadata by resolving known issues such as geographical name variations. This should result in a tool that will assist taxonomists in two ways. Firstly, it will be easier for them to discover relevant literature, especially pre-digital literature; and secondly, it will be easier for them to identify the canonical form for a citationThe paper also covers related issues relevant to building the tool in ViBRANT, including implementation and copyright, with suggestions as to how we could address them. PMID:22207811

  20. Quality of life in myopia

    PubMed Central

    Rose, K.; Harper, R.; Tromans, C.; Waterman, C.; Goldberg, D.; Haggerty, C.; Tullo, A.

    2000-01-01

    BACKGROUND—The safety and predictability of refractive surgery for all degrees of myopia is now becoming established. It is therefore appropriate to evaluate whether there is a patient driven demand for such treatments and, if so, to establish guidelines for its provision within the National Health Service (NHS).
METHODS—A comparative study was designed to assess the effect of degree of myopia on quality of life ("high" (n = 30) -10.00D, worse eye; "moderate" (n = 40) -4.00 to -9.75D, worse eye; "low" (n = 42) <-4.00D, worse eye) compared with a group of patients with keratoconus (n = 30) treated by optical correction. Data collection included binocular logMAR visual acuity, Pelli-Robson low contrast letter sensitivity, questionnaires to assess subjective visual function (VF-14) and effect on quality of life (VQOL), and semi-structured interviews.
RESULTS—There were no significant differences in any of the measures between patients with a high degree of myopia and those with keratoconus, or between those with a low and those with a moderate degree of myopia. However, those with a high degree of myopia had highly significantly poorer logMAR, VF-14, and VQOL scores than those with low and moderate myopia (p<0.001). Interview data supported these findings with patients with a high degree of myopia and those with keratoconus reporting that psychological, cosmetic, practical, and financial factors affected their quality of life.
CONCLUSION—Compared with low and moderate myopia, patients with a high degree of myopia experience impaired quality of life similar to that of patients with keratoconus. Criteria should therefore be identified to enable those in sufficient need to obtain refractive surgical treatment under the NHS.

 PMID:10966960

  1. Asthma Outcomes: Quality of Life

    PubMed Central

    Wilson, Sandra R.; Rand, Cynthia S.; Cabana, Michael D.; Foggs, Michael B.; Halterman, Jill S.; Olson, Lynn; Vollmer, William M.; Wright, Rosalind J.; Taggart, Virginia

    2014-01-01

    Background “Asthma-related quality of life” refers to the perceived impact that asthma has on the patient’s quality of life. Objective National Institutes of Health (NIH) institutes and other federal agencies convened an expert group to recommend standardized measures of the impact of asthma on quality of life for use in future asthma clinical research. Methods We reviewed published documentation regarding the development and psychometric evaluation; clinical research use since 2000; and extent to which the content of each existing quality of life instrument provides a unique, reliable, and valid assessment of the intended construct. We classified instruments as core (required in future studies), supplemental (used according to the study’s aims and standardized), or emerging (requiring validation and standardization). This work was discussed at an NIH-organized workshop convened in March 2010 and finalized in September 2011. Results Eleven instruments for adults and 6 for children were identified for review. None qualified as core instruments because they predominantly measured indicators of asthma control (symptoms and/or functional status); failed to provide a distinct, reliable score measuring all key dimensions of the intended construct; and/or lacked adequate psychometric data. Conclusions In the absence of existing instruments that meet the stated criteria, currently available instruments are classified as either supplemental or emerging. Research is strongly recommended to develop and evaluate instruments that provide a distinct, reliable measure of the patient’s perception of the impact of asthma on all of the key dimensions of quality of life, an important outcome that is not captured in other outcome measures. PMID:22386511

  2. Normative Ideas of Life and Autobiographical Reasoning in Life Narratives

    ERIC Educational Resources Information Center

    Bohn, Annette

    2011-01-01

    Autobiographical reasoning is closely related to the development of normative ideas about life as measured by the cultural life script. The acquisition of a life script is an important prerequisite for autobiographical reasoning because children learn through the life script which events are expected to go into their life story, and when to expect…

  3. Life Skills. Teacher Experiences. A Workshop Report.

    ERIC Educational Resources Information Center

    Utah State Board of Education, Salt Lake City.

    Twenty elementary and secondary teachers participated in workshops designed to present the rationale and process for identifying and effectively teaching parenting skills. Selected classroom experiences are described and analyzed by the teachers, and the grade level, curriculum, school, instructor and life skill involved are given. The skills were…

  4. What Sustains a Fulfilling Life in Education?

    ERIC Educational Resources Information Center

    Barnes, Jonathan M.

    2013-01-01

    Resilience is essential to the good teacher. This paper summarises research on factors that have sustained one life in education and compares them with narratives from nine other long-serving and fulfilled teachers. It identifies some elements that build teacher resilience and discusses how this knowledge might apply to teacher education and the…

  5. Life Management Skills. Florida Vocational Program Guide.

    ERIC Educational Resources Information Center

    Florida State Univ., Tallahassee. Center for Instructional Development and Services.

    This program guide identifies primary considerations in the organization, operation, and evaluation of a life management skills program. Program content is presented first. A curriculum framework specifies the exact course title, course number, levels of instruction, major course content, laboratory activities, special notes, major course…

  6. Skylab experiments. Volume 4: Life sciences

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The life sciences experiments conducted during Skylab missions are discussed. The general categories of the experiments are as follows: (1) mineral and hormonal balance, (2) hematology and immunology, (3) cardiovascular status, (4) energy expenditure, (5) neurophysiology, and (7) biology. Each experiment within the general category is further identified with respect to the scientific objectives, equipment used, performance, and data to be obtained.

  7. Life on Mars

    NASA Technical Reports Server (NTRS)

    McKay, Christopher P.; Cuzzi, Jeffrey (Technical Monitor)

    1996-01-01

    Although the Viking results may indicate that Mars has no life today, the possibility exists that Mars may hold the best record of the events that led to the origin of life. There is direct geomorphological evidence that in the past Mars had large amounts of liquid water on its surface. Atmospheric models would suggest that this early period of hydrological activity was due to the presence of a thick atmosphere and the resulting warmer temperatures. From a biological perspective the existence of liquid water, by itself motivates the question of the origin of life on Mars. From studies of the Earth's earliest biosphere we know that by 3.5 Gyr. ago, life had originated on Earth and reached a fair degree of biological sophistication. Surface activity and erosion on Earth make it difficult to trace the history of life before the 3.5 Gyr timeframe. If Mars did maintain a clement environment for longer than it took for life to originate on Earth, then the question of the origin of life on Mars follows naturally.

  8. Battery Life Data Analysis

    Energy Science and Technology Software Center (ESTSC)

    2008-07-01

    The FreedomCar Partnership has established life goals for batteries. Among them is a 15 year calendar life. The software and the underlying methodology attempt to predict cell and battery life using, at most, two years of test data. The software uses statistical models based on data from accelerated aging experiments to estimate cell life. The life model reflects the average cell performance under a given set of stress conditions with time. No specific form ofmore » the life model is assumed. The software will fit the model to experimental data. An error model, reflecting the cell-to-cell variability and measurement errors, is included in the software. Monte Carlo simulations, based on the developed models, are used to assess Lack-of-fit and develop uncertainty limis for the average cell life. The software has three operating modes: fit only, fit and simulation and simulation only. The user is given these options by means of means and alert boxes.« less

  9. Identifying teaching in wild animals.

    PubMed

    Thornton, Alex; Raihani, Nichola J

    2010-08-01

    After a long period of neglect, the study of teaching in nonhuman animals is beginning to take a more prominent role in research on social learning. Unlike other forms of social learning, teaching requires knowledgeable individuals to play an active role in facilitating learning by the naive. Casting aside anthropocentric requirements for cognitive mechanisms assumed to underpin teaching in our own species, researchers are now beginning to discover evidence for teaching across a wide range of taxa. Nevertheless, unequivocal evidence for teaching remains scarce, with convincing experimental data limited to meerkats, pied babblers, and tandem-running ants. In this review, our aim is to stimulate further research in different species and contexts by providing conceptual and methodological guidelines for identifying teaching, with a focus on natural populations. We begin by highlighting the fact that teaching is a form of cooperative behavior that functions to promote learning in others and show that consideration of these key characteristics is critical in helping to identify suitable targets for future research. We then go on to discuss potential observational, experimental, and statistical techniques that may assist researchers in providing evidence that the criteria that make up the accepted operational definition of teaching have been met. Supplemental materials for this article may be downloaded from http://lb.psychonomic-journals.org/content/supplemental. PMID:20628167

  10. Life, autonomy and cognition: an organizational approach to the definition of the universal properties of life.

    PubMed

    Bich, Leonardo; Damiano, Luisa

    2012-10-01

    This article addresses the issue of defining the universal properties of living systems through an organizational approach, according to which the distinctive properties of life lie in the functional organization which correlates its physicochemical components in living systems, and not in these components taken separately. Drawing on arguments grounded in this approach, this article identifies autonomy, with a set of related organizational properties, as universal properties of life, and includes cognition within this set. PMID:23065409

  11. Exobiology, Jupiter and life.

    NASA Technical Reports Server (NTRS)

    Molton, P. M.

    1972-01-01

    Recent experiments in an environmental chamber have shown that not even hardy terrestrial bacteria can survive on the Martian surface. The planet Jupiter is now considered by many to be the most likely place to find nonterrestrial life. Atmospheric simulation experiments for Jupiter that have been performed involve spark or semicorona discharges in mixtures of methane and ammonia at room temperature and a pressure lower than atmospheric. Terrestrial microorganisms have been shown capable of surviving 24 hr under a range of possible Jovian atmospheric conditions. The final mode of approach to the question of Jovian life concerns theoretical studies on the sort of chemical systems from which life could be generated.

  12. "Geriatricizing" hospitalists: identifying educational opportunities.

    PubMed

    Friedman, Susan M; Gillespie, Suzanne M; Medina-Walpole, Annette M; Caprio, Thomas V; Karuza, Jurgis; McCann, Robert M

    2013-01-01

    The objective of this study was to identify differences between geriatricians and hospitalists in caring for hospitalized older adults, so as to inform faculty development programs that have the goal of improving older patient care. Eleven hospitalists and 13 geriatricians were surveyed regarding knowledge, confidence, and practice patterns in caring for hospitalized older adults, targeting areas previously defined as central to taking care of older hospitalized patients. Overall, geriatricians had more confidence and more knowledge in caring for older hospitalized adults. The areas in which hospitalists expressed the least confidence were in caring for patients with dementia, self-care issues, and care planning. Geriatricians reported more routine medication reviews, functional and cognitive assessments, and fall evaluations. Geriatricians and hospitalists differ in their approach to older adults. Where these differences reflect lack of knowledge or experience, they set the stage for developing curricula to help narrow these gaps. PMID:23971409

  13. Important caves to be identified

    NASA Astrophysics Data System (ADS)

    Criteria to identify significant caves on federal land are being developed by the Interior Department's Bureau of Land Management and the Agriculture Department's Forest Service under requirements of the Federal Cave Resources Protection Act of 1988. The departments gave advance notice of proposed rulemaking March 3 and invited suggestions and comments from the public for 30 days.The law requires protection, to the extent practical, of significant caves on lands administered by the Secretaries of Agriculture and Interior and includes authority to issue and revoke permits for collection and removal of cave resources and special provisions for regulation of cave resources on Indian lands. Final regulations must be published by August 18, 1989.

  14. Identifying methamphetamine exposure in children

    PubMed Central

    Castaneto, Marisol S.; Barnes, Allan J.; Scheidweiler, Karl B.; Schaffer, Michael; Rogers, Kristen K.; Stewart, Deborah; Huestis, Marilyn A.

    2013-01-01

    Introduction Methamphetamine (MAMP) use, distribution and manufacture remain a serious public health and safety problem in the United States, and children environmentally exposed to MAMP face a myriad of developmental, social and health risks, including severe abuse and neglect necessitating child protection involvement. It is recommended that drug-endangered children receive medical evaluation and care with documentation of overall physical and mental conditions and have urine drug testing.1 The primary aim of this study was to determine the best biological matrix to detect MAMP, amphetamine (AMP), methylenedioxymethamphetamine (MDMA), methylenedioxyamphetamine (MDA) and methylenedioxyethylamphetamine (MDEA) in environmentally exposed children. Method 91 children, environmentally exposed to household MAMP intake, were medically evaluated at the Child and Adolescent Abuse Resource and Evaluation (CAARE) Diagnostic and Treatment Center at the University of California, Davis (UCD) Children's Hospital. MAMP, AMP, MDMA, MDA and MDEA were quantified in urine and oral fluid (OF) by gas chromatography mass spectrometry (GCMS) and in hair by liquid chromatography tandem mass spectrometry (LCMSMS). Results Overall drug detection rates in OF, urine and hair were 6.9%, 22.1% and 77.8%, respectively. Seventy children (79%) tested positive for 1 or more drugs in 1 or more matrices. MAMP was the primary analyte detected in all 3 biological matrices. All positive OF (n=5) and 18 of 19 positive urine specimens also had a positive hair test. Conclusion Hair analysis offered a more sensitive tool for identifying MAMP, AMP and MDMA environmental exposure in children than urine or OF testing. A negative urine, or hair test does not exclude the possibility of drug exposure, but hair testing provided the greatest sensitivity for identifying drug-exposed children. PMID:24263642

  15. Medicine's Life Inside the Body

    MedlinePlus

    ... A Medicine's Life Inside the Body Inside Life Science View All Articles | Inside Life Science Home Page A Medicine's Life Inside the Body ... Work Computation Aids Drug Discovery This Inside Life Science article also appears on LiveScience . Learn about related ...

  16. Identifying atmospheric monitoring needs for Space Station Freedom

    NASA Technical Reports Server (NTRS)

    Casserly, Dennis M.

    1989-01-01

    The atmospheric monitoring needs for Space Station Freedom were identified by examining the following from an industrial hygiene perspective: the experiences of past missions; ground based tests of proposed life support systems; the unique experimental and manufacturing facilities; the contaminant load model; metabolic production; and a fire. A target list of compounds to be monitored is presented and information is provided relative to the frequency of analysis, concentration ranges, and locations for monitoring probes.

  17. Novel hantavirus identified in black-bearded tomb bats, China.

    PubMed

    Xu, Lin; Wu, Jianmin; He, Biao; Qin, Shaomin; Xia, Lele; Qin, Minchao; Li, Nan; Tu, Changchun

    2015-04-01

    Hantaviruses cause life-threatening diseases in human worldwide. Rodents, insectivores and bats are known hantaviral reservoirs, but lack of complete genomic sequences of bat-borne hantaviruses impedes phylogenetic and evolutionary comparison with those of rodents and insectivores. Here, a novel bat-borne hantavirus, Laibin virus (LBV), has been identified in a black-bearded tomb bat in China. The complete genomic sequence shows that LBV is only distantly related to all previously known bat-borne hantaviruses. PMID:25643870

  18. My Reproductive Life Plan

    MedlinePlus

    ... Information For... Media Policy Makers My Reproductive Life Plan Language: English Español (Spanish) Recommend on Facebook Tweet ... use with their patients. How to Make a Plan First, think about your goals for school, for ...

  19. Regenerative Life Support Evaluation

    NASA Technical Reports Server (NTRS)

    Kleiner, G. N.; Thompson, C. D.

    1977-01-01

    This paper describes the development plan and design concept of the Regenerative Life Support Evaluation (RLSE) planned for flight testing in the European Space Agency Spacelab. The development plan encompasses the ongoing advanced life support subsystem and a systems integration effort to evolve concurrently subsystem concepts that perform their function and can be integrated with other subsystems in a flight demonstration of a regenerative life support system. The design concept for RLSE comprises water-electrolysis O2 generation, electrochemically depolarized CO2 removal, and Sabatier CO2 reduction for atmosphere regeneration, urine vapor-compression distillation, and wash-water hyperfiltration for waste-water recovery. The flight demonstration by RLSE is an important step in qualifying the regenerative concepts for life support in space stations.

  20. Life under alien skies

    NASA Astrophysics Data System (ADS)

    Dartnell, Lewis

    2012-04-01

    As the number of confirmed extrasolar planets increases, so does the likelihood that some of them will harbour life. Lewis Dartnell describes some preliminary - but increasingly well founded - efforts to predict what alien plants and animals might look like.

  1. First Day of Life

    MedlinePlus

    ... Things to Know About Zika & Pregnancy The First Day of Life KidsHealth > For Parents > The First Day ... continue What Your Baby Does on the First Day Many parents are surprised to see how alert ...

  2. Is life supernatural?

    NASA Astrophysics Data System (ADS)

    Levin, Gilbert V.

    2015-09-01

    The big question of the origin of life is examined. The paradox created by Pasteur's resounding edict: Life only comes from life, pitted against the need for spontaneous generation is explored. This seemingly dead-end conundrum contrasts sharply with the great progress we have made in understanding the evolution of the species since Darwin's revolutionary insight. The conditions and sources of energy that might have promoted non-living molecules and compounds to cross the sharp line from inert to living are contemplated. Abiotic synthesis might help explain the origin, but still fails to explain the moment of vitalization. A different approach to discovering when the inert becomes alive is proposed. The need for, and a way to bring forth, a "Bio-Einstein" to solve this penultimate question of life's origin are presented.

  3. Life on moduli space?

    SciTech Connect

    Hsu, Stephen D. H.

    2009-10-15

    While the number of metastable landscape vacua in string theory is vast, the number of supermoduli vacua which lead to distinct low-energy physics is even larger, perhaps infinitely so. From the anthropic perspective it is therefore important to understand whether complex life is possible on moduli space - i.e., in low-energy effective theories with (1) exact supersymmetry and (2) some massless multiplets (moduli). Unless life is essentially impossible on moduli space as a consequence of these characteristics, anthropic reasoning in string theory suggests that the overwhelming majority of sentient beings would observe 1-2. We investigate whether 1 and 2 are by themselves automatically inimical to life and conclude, tentatively, that they are not. In particular, we describe moduli scenarios in which complex life seems possible.

  4. End of Life Issues

    MedlinePlus

    ... difficult. But by deciding what end-of-life care best suits your needs when you are healthy, ... making choices about the following: The goals of care (for example, whether to use certain medicines during ...

  5. Diversity of Life Possible

    NASA Video Gallery

    Planets are distinguished by two basic properties, their size and their orbit. The size determines if the planet can have a life-sustaining atmosphere. The orbit affects the surface temperature and...

  6. Battery Life Predictive Model

    Energy Science and Technology Software Center (ESTSC)

    2009-12-31

    The Software consists of a model used to predict battery capacity fade and resistance growth for arbitrary cycling and temperature profiles. It allows the user to extrapolate from experimental data to predict actual life cycle.

  7. Life Stories: Personal Portraits.

    ERIC Educational Resources Information Center

    Moore, John Noell, Ed.

    2001-01-01

    Offers glimpses into the landscapes of people's lives. Discusses Edith Bruck's "Who Loves You Like This,""Life Stories: Profiles from 'The New Yorker'," and Hugh Sidey's "Portraits of the Presidents: Power and Personality in the Oval Office." (SG)

  8. Fresh Water Life.

    ERIC Educational Resources Information Center

    Kestler, Carol Susan

    1991-01-01

    Describes methodology for a fresh water life study with elementary through college age students with suggestions for proper equipment, useful guides, and other materials. Proposes an activity for the collection and study of plankton. Includes background information.(MCO)

  9. Bioinformatic analysis of expression data to identify effector candidates.

    PubMed

    Reid, Adam J; Jones, John T

    2014-01-01

    Pathogens produce effectors that manipulate the host to the benefit of the pathogen. These effectors are often secreted proteins that are upregulated during the early phases of infection. These properties can be used to identify candidate effectors from genomes and transcriptomes of pathogens. Here we describe commonly used bioinformatic approaches that (1) allow identification of genes encoding predicted secreted proteins within a genome and (2) allow the identification of genes encoding predicted secreted proteins that are upregulated at important stages of the life cycle. Other approaches for bioinformatic identification of effector candidates, including OrthoMCL analysis to identify expanded gene families, are also described. PMID:24643549

  10. Life After Breast Cancer Treatment

    MedlinePlus

    FACTS FOR LIFE Life After Breast Cancer Treatment Once breast cancer treatment ends, you may face a new set of issues and concerns. ... fear. If fear starts to disrupt your daily life, talk to your doctor. Getting the support and ...

  11. Priority Planetary Science Missions Identified

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2011-03-01

    The U.S. National Research Council's (NRC) planetary science decadal survey report, released on 7 March, lays out a grand vision for priority planetary science missions for 2013-2022 within a tightly constrained fiscal environment. The cost-conscious report, issued by NRC's Committee on the Planetary Science Decadal Survey, identifies high-priority flagship missions, recommends a number of potential midsized missions, and indicates support for some smaller missions. The report states that the highest-priority flagship mission for the decade is the Mars Astrobiology Explorer-Cacher (MAX-C)—the first of three components of a NASA/European Space Agency Mars sample return campaign—provided that the mission scope can be reduced so that MAX-C costs no more than $2.5 billion. The currently estimated mission cost of $3.5 billion “would take up a disproportionate near-term share of the overall budget for NASA's Planetary Science Division,” the report notes.

  12. Can tests identify creative people?

    NASA Astrophysics Data System (ADS)

    Bell, Peter M.

    It is always a popular pursuit by academic administrators to assess the creativity or innovative qualities of scientists in order to evaluate their research capabilities. Of course, traditionally such evaluations have been fraught with subjectivity (i.e., innovative scientists are commonly thought to be weird, under 40 years old, independent, risk-taking, etc.), and thus such evaluations have not been highly valued. In recent years, through testing, the American Chemical Society (ACS) has attempted to give respectability to the art of predicting the creativity of a scientist. ACS, which draws its members from both industrial and academic laboratories, held a symposium on the subject of evaluating the creativity of scientists. The proceedings were published by ACS as ‘Innovation and U.S. Research: Problems and Recommendations’ (W. N. Smith and C.F. Larson, eds., 1980). In the proceedings, as reported in the July 1982 Chemtec (all quotes here are from the Chemtec article), A. Nisson was able to identify only the following two-part characteristic of an innovative person: (1) a low threshold to ‘a state of discomfort with some aspect of the order of things, the status quo,’ and (2) ‘an extraordinarily high level of mental stamina enabling him or her to persist until the state of discomfort is removed.’

  13. Identifying compartmentalization in gas reservoirs

    SciTech Connect

    Junkin, J.; Cooper, K.; Sippel, M.

    1997-01-01

    Compartmentalization as a function of depositional systems is now recognized as a common type of reservoir heterogeneity that limits recovery from oil and gas reservoirs. US Department of Energy (DOE) estimates indicate that substantial quantities of gas resources will not be recovered from presently identified reservoirs under historic development practices. The Secondary Natural Gas Recovery (SGR) project sponsored by the Gas Research Institute (GRI), state of Texas and DOE quantified compartmentalization over intervals as large as 2,000 feet in several different fluvial deltaic reservoirs. Early recognition of compartmentalized behavior can be used to pursue a more rapid development plan including efficient well spacing and elimination of redundant wells. Three classes of reservoir compartment sizes were delineated in the SGR project using methods discussed in this article. Forward stochastic modeling of gas recovery from these compartment-size classes established well spacing requirements that would yield maximum gas contact efficiency. The presence of reservoir compartmentalization was also shown to correlate with reserve growth. Also, those reservoirs classified as having smaller compartment sizes exhibited the greatest reserve growth potential. Utilization of tools, such as personal computer-based methods discussed, enables better engineering interpretation of actual field behavior. Some of these tools require minimal production data, which is readily available on CD-ROM or via modem at very low cost.

  14. RECOVIR Software for Identifying Viruses

    NASA Technical Reports Server (NTRS)

    Chakravarty, Sugoto; Fox, George E.; Zhu, Dianhui

    2013-01-01

    Most single-stranded RNA (ssRNA) viruses mutate rapidly to generate a large number of strains with highly divergent capsid sequences. Determining the capsid residues or nucleotides that uniquely characterize these strains is critical in understanding the strain diversity of these viruses. RECOVIR (an acronym for "recognize viruses") software predicts the strains of some ssRNA viruses from their limited sequence data. Novel phylogenetic-tree-based databases of protein or nucleic acid residues that uniquely characterize these virus strains are created. Strains of input virus sequences (partial or complete) are predicted through residue-wise comparisons with the databases. RECOVIR uses unique characterizing residues to identify automatically strains of partial or complete capsid sequences of picorna and caliciviruses, two of the most highly diverse ssRNA virus families. Partition-wise comparisons of the database residues with the corresponding residues of more than 300 complete and partial sequences of these viruses resulted in correct strain identification for all of these sequences. This study shows the feasibility of creating databases of hitherto unknown residues uniquely characterizing the capsid sequences of two of the most highly divergent ssRNA virus families. These databases enable automated strain identification from partial or complete capsid sequences of these human and animal pathogens.

  15. Factors identified for negative appendicectomies.

    PubMed

    Mirza, M R; Habib, L; Jaleel, F

    2009-07-01

    The study was done, to determine the factors for negative appendicectomies. This prospective descriptive study includes patients managed at four non teaching and a teaching hospital of Karachi from March 2006 to February 2008. One hundred and sixty eight patients underwent appendicectomy during the study period. Details of clinical presentations, investigations, operative findings and histopathology were entered and analyzed. Literature search was aimed to see the negative appendicectomy rate (NAR) in last ten years despite using diagnostic tools (clinical scoring, diagnostic imaging and laparoscopy). In this study a total number of 168 patients under went appendicectomy. Normal appendices were found in 31 patients (negative appendicectomy rate was 18.45%) and associated pathology was seen in 13 patients, an incidental finding of Meckel's diverticulum in 5 patients and no other pathology was seen in 13 patients. The different factors which we identified for negative appendicectomies in our practice were non teaching hospitals where diagnostic scoring system was difficult to apply, female gender, selective use of imaging modality, other pathologies presenting with pain in right lower quadrant (RLQ) and requiring surgical intervention, and non-availability of CT scan and laparoscopy. Despite many advances in diagnostic system, acute appendicitis is still a diagnostic dilemma at times. Although there is no substitute for clinical judgment but in sub groups of patients in whom the possibility of negative appendicectomy is high, diagnostic modalities should be used judiciously to decrease the negative exploration. PMID:19623147

  16. Reflections on the Life Histories of Today's LGBQ Postsecondary Students

    ERIC Educational Resources Information Center

    Olive, James L.

    2012-01-01

    This qualitative multiple-case study utilized a life history methodology in which written and oral narratives were obtained from six postsecondary students who self-identified as lesbian, gay, bisexual, and/or queer (LGBQ). Through the construction of life histories, the researcher endeavored to understand how past experiences and behaviors shaped…

  17. Life Science Payloads Planning Study Integration Facility Survey: Executive Summary

    NASA Technical Reports Server (NTRS)

    Wells, G. W.; Brown, N. E.

    1976-01-01

    Analyses of proposed life science shuttle era payload operations are discussed. A summary of results from a survey conducted to: (1) examine facility and equipment resources needed for life science payload integration, checkout, test and mission support activities; (2) identify presently available resources; and (3) determine methods by which operational era status may be implemented based on currently available resources, is presented.

  18. Using Peer Health Education to Enhance Family Life Education

    ERIC Educational Resources Information Center

    Puentes, William J.; Wassel, Melanie

    2003-01-01

    This article describes an intervention known as the Peer Family Life Education Project that was designed as an alternate delivery method of an established family life education curriculum in an urban middle school setting. The factors contributing to sexual risk behaviors by urban adolescent populations are identified. A review of previous efforts…

  19. Seven Traits Define Leaders among Student Life Professionals.

    ERIC Educational Resources Information Center

    Haines, Dana Lee

    2000-01-01

    Identifies seven character traits characteristic of leaders among student life professionals: influence, values, integrity, trust, self-discipline, empathy, and attitude. Student life professionals are urged to periodically examine themselves in light of these traits as they build their leadership skills. (DB)

  20. A Motivational Theory of Life-Span Development

    ERIC Educational Resources Information Center

    Heckhausen, Jutta; Wrosch, Carsten; Schulz, Richard

    2010-01-01

    This article had four goals. First, the authors identified a set of general challenges and questions that a life-span theory of development should address. Second, they presented a comprehensive account of their Motivational Theory of Life-Span Development. They integrated the model of optimization in primary and secondary control and the…

  1. Work-Life Balance: Beyond the Rhetoric. IES Report.

    ERIC Educational Resources Information Center

    Kodz, J.; Harper, H.; Dench, S.

    The current status of British policy and practice related to work-life balance was examined through case studies of six organizations identified as having well-developed work-life balance and flexible working practices. Interviews were conducted with human resource (HR) managers at all six organizations, and interviews and focus group discussions…

  2. Remaining Useful Life Estimation in Prognosis: An Uncertainty Propagation Problem

    NASA Technical Reports Server (NTRS)

    Sankararaman, Shankar; Goebel, Kai

    2013-01-01

    The estimation of remaining useful life is significant in the context of prognostics and health monitoring, and the prediction of remaining useful life is essential for online operations and decision-making. However, it is challenging to accurately predict the remaining useful life in practical aerospace applications due to the presence of various uncertainties that affect prognostic calculations, and in turn, render the remaining useful life prediction uncertain. It is challenging to identify and characterize the various sources of uncertainty in prognosis, understand how each of these sources of uncertainty affect the uncertainty in the remaining useful life prediction, and thereby compute the overall uncertainty in the remaining useful life prediction. In order to achieve these goals, this paper proposes that the task of estimating the remaining useful life must be approached as an uncertainty propagation problem. In this context, uncertainty propagation methods which are available in the literature are reviewed, and their applicability to prognostics and health monitoring are discussed.

  3. Student's Life-Style Classifications: Key to Improved Literacy Programs.

    ERIC Educational Resources Information Center

    Martin, Larry G.

    1986-01-01

    Classifies student life-styles as entrepreneurs, superiors, regulars, suppliants, marginals, and underclass. Identifies demographic and attitudinal differences among these groups and discusses implications for programming decisions in adult literacy programs. (SK)

  4. Life sciences recruitment objectives

    NASA Technical Reports Server (NTRS)

    Keefe, J. Richard

    1992-01-01

    The goals of the Life Sciences Division of the Office of Space Sciences and Application are to ensure the health, well being and productivity of humans in space and to acquire fundamental scientific knowledge in space life sciences. With these goals in mind Space Station Freedom represents substantial opportunities and significant challenges to the Life Sciences Division. For the first time it will be possible to replicate experimental data from a variety of simultaneously exposed species with appropriate controls and real-time analytical capabilities over extended periods of time. At the same time, a system for monitoring and ameliorating the physiological adaptations that occur in humans subjected to extended space flight must be evolved to provide the continuing operational support to the SSF crew. To meet its goals, and take advantage of the opportunities and overcome the challenges presented by Space Station Freedom, the Life Sciences Division is developing a suite of discipline-focused sequence. The research phase of the Life Sciences Space Station Freedom Program will commence with the utilization flights following the deployment of the U.S. laboratory module and achievement of Man Tended Capability. Investigators that want the Life Sciences Division to sponsor their experiment on SSF can do so in one of three ways: submitting a proposal in response to a NASA Research Announcement (NRA), submitting a proposal in response to an Announcement of Opportunity (AO), or submitting an unsolicited proposal. The scientific merit of all proposals will be evaluated by peer review panels. Proposals will also be evaluated based on relevance to NASA's missions and on the results of an Engineering and Cost Analyses. The Life Sciences Division expects that the majority of its funding opportunities will be announced through NRA's. It is anticipated that the first NRA will be released approximately three years before first element launch (currently scheduled for late 1995

  5. Life without water

    NASA Technical Reports Server (NTRS)

    Crowe, Lois M.; Crowe, John H.

    1989-01-01

    Anhydrobiosis, or life without water is commonly demonstrated by a number of plants and animals. These organisms have the capacity to loose all body water, remain dry for various periods, and then be revived by rehydration. While in the anhydrobiotic state, these organisms become highly resistant to several environmental stresses such as extremely low temperatures, elevated temperatures, ionizing radiation, and high vacuum. Since water is commonly thought to be essential for life, survival of anhydrobiotic organisms with an almost total loss of water is examined. A search of literature reveal that many anhydrobiotic organisms make large quantities of trehalose or other carbohydrates. Laboratory experiments have shown that trehalose is able to stabilize and preserve microsomes of sarcoplasmic reticulum and artificial liposomes. It was demonstrated that trehalose and other disaccharides can interact directly with phosopipid headgroups and maintain membranes in their native configuration by replacing water in the headgroup region. Recent studies show that trehalose is an effective stabilizer of proteins during drying and that it does so by direct interaction with groups on the protein. If life that is able to withstand environmental extremes has ever developed on Mars, it is expected that such life would have developed some protective compounds which can stabilize macromolecular structure in the absence of water and at cold temperatures. On Earth, that role appears to be filled by carbohydrates that can stabilize both membrane and protein stuctures during freezing and drying. By analog with terrestrial systems, such life forms might develop resistance either during some reproductive stage or at any time during adult existence. If the resistant form is a developmental stage, the life cycle of the organism must be completed with a reasonable time period relative to time when environmental conditions are favorable. This would suggest that simple organisms with a short

  6. Valued life abilities among veteran cancer survivors

    PubMed Central

    Karel, Michele J.; Mulligan, Elizabeth A.; Walder, Annette; Martin, Lindsey A.; Moye, Jennifer; Naik, Aanand D.

    2016-01-01

    Background When patients have multiple chronic illnesses, it is not feasible to provide disease-based care when treatments for one condition adversely affect another. Instead, health-care delivery requires a broader person-centred treatment plan based on collaborative, patient-oriented values and goals. Objective We examined the individual variability, thematic content, and sociodemographic correlates of valued life abilities and activities among multimorbid veterans diagnosed with life-altering cancer. Setting and participants Participants were 144 veterans in the ‘Vet-Cares’ study who completed a health-care values and goals scale 12 months after diagnosis of head and neck, gastro-oesophageal, or colorectal cancer. They had mean age of 65 years and one quarter identified as Hispanic and/or African American. Design At twelve months post-diagnosis, participants rated 16 life abilities/activities in their importance to quality of life on a 10-point Likert scale, during an in-person interview. Scale themes were validated via exploratory factor analysis and examining associations with sociodemographic variables. Results Participants rated most life abilities/activities as extremely important. Variability in responses was sufficient to identify three underlying values themes in exploratory factor analysis: self-sufficiency, enjoyment/comfort, and connection to family, friends and spirituality. Veterans with a spouse/partner rated self-sufficiency as less important. African American veterans rated connection as more important than did White veterans. Conclusions It is feasible yet challenging to ask older, multimorbid patients to rate relative importance of values associated with life abilities/activities. Themes related to self-sufficiency, enjoyment/comfort in daily life and connection are salient and logically consistent with sociodemographic traits. Future studies should explore their role in goal-directed health care. PMID:25645124

  7. DNA Microarrays for Identifying Fishes

    PubMed Central

    Nölte, M.; Weber, H.; Silkenbeumer, N.; Hjörleifsdottir, S.; Hreggvidsson, G. O.; Marteinsson, V.; Kappel, K.; Planes, S.; Tinti, F.; Magoulas, A.; Garcia Vazquez, E.; Turan, C.; Hervet, C.; Campo Falgueras, D.; Antoniou, A.; Landi, M.; Blohm, D.

    2008-01-01

    In many cases marine organisms and especially their diverse developmental stages are difficult to identify by morphological characters. DNA-based identification methods offer an analytically powerful addition or even an alternative. In this study, a DNA microarray has been developed to be able to investigate its potential as a tool for the identification of fish species from European seas based on mitochondrial 16S rDNA sequences. Eleven commercially important fish species were selected for a first prototype. Oligonucleotide probes were designed based on the 16S rDNA sequences obtained from 230 individuals of 27 fish species. In addition, more than 1200 sequences of 380 species served as sequence background against which the specificity of the probes was tested in silico. Single target hybridisations with Cy5-labelled, PCR-amplified 16S rDNA fragments from each of the 11 species on microarrays containing the complete set of probes confirmed their suitability. True-positive, fluorescence signals obtained were at least one order of magnitude stronger than false-positive cross-hybridisations. Single nontarget hybridisations resulted in cross-hybridisation signals at approximately 27% of the cases tested, but all of them were at least one order of magnitude lower than true-positive signals. This study demonstrates that the 16S rDNA gene is suitable for designing oligonucleotide probes, which can be used to differentiate 11 fish species. These data are a solid basis for the second step to create a “Fish Chip” for approximately 50 fish species relevant in marine environmental and fisheries research, as well as control of fisheries products. PMID:18270778

  8. Life saving surgery in polytrauma patients.

    PubMed

    Broos, P L; Janzing, H M; Vandermeeren, L A; Klockaerts, K S

    2000-01-01

    Life saving surgery is the surgery which has to be performed during the acute or reanimation period (1 to 3 h) and during the primary or stabilisation period (first day surgery). During the reanimation period lifethreatening conditions are identified and management is begun simultaneously. Many trauma surgeons talk about the first "golden hours" as the time interval starting immediately after the injury when rapid intervention will save lives and a lack of intervention will result in life loss. Most common, these critical conditions are exsanguinating hemorrhage, acute pump failure, obstruction of airways, mechanical failure of ventilation or severe brain damage with tentorial herniation. During this period, the following acts are necessary: surgical access to live support systems (airway, veins), life saving decompression of body cavities, resuscitative thoracotomy, control of exsanguinating external hemorrhage and control of exsanguinating hemorrhage into the body cavities. The primary or stabilisation period starts when vital functions stabilise. This period consists of further diagnostic procedures and treatment of injuries that are not directly life-threatening, but which may become life endangering or severely disabling if not treated promptly. The priorities of the surgical treatment are: brain injuries, eye- and facial injuries, progressive compression of the spinal cord, visceral injuries, musculoskeletal injuries. By improving prehospital care, rapid transport and last but not least immediate life saving surgical treatment preventable deaths can be reduced from 20-30% to 2-9% (5). PMID:11202271

  9. An Integrated Approach to Life Cycle Analysis

    NASA Technical Reports Server (NTRS)

    Chytka, T. M.; Brown, R. W.; Shih, A. T.; Reeves, J. D.; Dempsey, J. A.

    2006-01-01

    Life Cycle Analysis (LCA) is the evaluation of the impacts that design decisions have on a system and provides a framework for identifying and evaluating design benefits and burdens associated with the life cycles of space transportation systems from a "cradle-to-grave" approach. Sometimes called life cycle assessment, life cycle approach, or "cradle to grave analysis", it represents a rapidly emerging family of tools and techniques designed to be a decision support methodology and aid in the development of sustainable systems. The implementation of a Life Cycle Analysis can vary and may take many forms; from global system-level uncertainty-centered analysis to the assessment of individualized discriminatory metrics. This paper will focus on a proven LCA methodology developed by the Systems Analysis and Concepts Directorate (SACD) at NASA Langley Research Center to quantify and assess key LCA discriminatory metrics, in particular affordability, reliability, maintainability, and operability. This paper will address issues inherent in Life Cycle Analysis including direct impacts, such as system development cost and crew safety, as well as indirect impacts, which often take the form of coupled metrics (i.e., the cost of system unreliability). Since LCA deals with the analysis of space vehicle system conceptual designs, it is imperative to stress that the goal of LCA is not to arrive at the answer but, rather, to provide important inputs to a broader strategic planning process, allowing the managers to make risk-informed decisions, and increase the likelihood of meeting mission success criteria.

  10. What is life? Prerequisites for a definition.

    PubMed Central

    Dix, Douglas E.

    2002-01-01

    Biologists view life as transient while theologians see it as eternal. An unbiased definition for life would respect both views until one or both were eliminated by evidence. This paper identifies pre-requisites for such a definition. First among these is that all assumptions be made explicit. Currently "life" is surrounded by implicit assumptions, e.g., that it is what organisms lose at death or that it is eternal, that its quality is inversely related to personal distress, that it originated some four billion years ago, and that animate matter can be distinguished from inanimate matter. None of these assumptions are supported by data. It is possible therefore that "life" is as meaningless as phlogiston. If life has meaning, i.e., if it is true, it must be as permanent as buoyancy, gravity, electricity, and the other truths of nature. Any definition for life that would permit such truth to be seen must be free of unwarranted assumptions. For the moment, at least, such a definition would need to be loosely structured and broadly focused. It would need to describe the long and convoluted process by which matter and energy form organisms which then evolve to form conscious organisms which then explore nature and eventually discover truth. Such a definition would include all the reactions and interactions of matter and energy and all the aspects of conscious discovery. It would suffer from superficiality, but, by being free from bias, provide a foundation for dialogue between biologists and theologians. PMID:14580113

  11. Life Satisfaction in Adult Survivors of Childhood Brain Tumors

    PubMed Central

    Crom, Deborah B.; Li, Zhenghong; Brinkman, Tara M.; Hudson, Melissa M.; Armstrong, Gregory T.; Neglia, Joseph; Ness, Kirsten K.

    2014-01-01

    Adult survivors of childhood brain tumors experience multiple, significant, life-long deficits as a consequence of their malignancy and therapy. Current survivorship literature documents the substantial impact such impairments have on survivors’ physical health and quality of life. Psychosocial reports detail educational, cognitive, and emotional limitations characterizing survivors as especially fragile, often incompetent, and unreliable in evaluating their circumstances. Anecdotal data suggests some survivors report life experiences similar to those of healthy controls. The aim of our investigation was to determine whether life satisfaction in adult survivors of childhood brain tumors differs from that of healthy controls and to identify potential predictors of life satisfaction in survivors. This cross-sectional study compared 78 brain tumor survivors with population–based matched controls. Chi-square tests, t-tests, and linear regression models were used to investigate patterns of life satisfaction and identify potential correlates. Results indicated life satisfaction of adult survivors of childhood brain tumors was similar to that of healthy controls. Survivors’ general health expectations emerged as the primary correlate of life satisfaction. Understanding life satisfaction as an important variable will optimize the design of strategies to enhance participation in follow-up care, reduce suffering, and optimize quality of life in this vulnerable population. PMID:25027187

  12. USSR Space Life Sciences Digest, issue 31

    NASA Technical Reports Server (NTRS)

    Hooke, Lydia Razran (Editor); Teeter, Ronald (Editor); Garshnek, Victoria (Editor); Rowe, Joseph (Editor)

    1990-01-01

    This is the thirty first issue of NASA's Space Life Sciences Digest. It contains abstracts of 55 journal papers or book chapters published in Russian and of 5 Soviet monographs. Selected abstracts are illustrated with figures and tables from the original. The abstracts in this issue have been identified as relevant to 18 areas of space biology and medicine. These areas include: adaptation, biological rhythms, cardiovascular and respiratory systems, endocrinology, enzymology, genetics, group dynamics, habitability and environmental effects, hematology, life support systems, metabolism, microbiology, musculoskeletal system, neurophysiology, nutrition, operational medicine, psychology, radiobiology, and space biology and medicine.

  13. USSR Space Life Sciences Digest, issue 30

    NASA Technical Reports Server (NTRS)

    Stone, Lydia Razran (Editor); Teeter, Ronald (Editor); Rowe, Joseph (Editor)

    1991-01-01

    This is the thirtieth issue of NASA's Space Life Sciences Digest. It contains abstracts of 47 journal papers or book chapters published in Russian and of three Soviet monographs. Selected abstracts are illustrated with figures and tables from the original. The abstracts in this issue have been identified as relevant to 20 areas of space biology and medicine. These areas include: adaptation, biospheric research, cardiovascular and respiratory systems, endocrinology, equipment and instrumentation, gastrointestinal system, group dynamics, habitability and environmental effects, hematology, human performance, immunology, life support systems, mathematical modeling, metabolism, musculoskeletal system, neurophysiology, nutrition, psychology, radiobiology, and space biology and medicine.

  14. USSR Space Life Sciences Digest, issue 28

    NASA Technical Reports Server (NTRS)

    Stone, Lydia Razran (Editor); Teeter, Ronald (Editor); Rowe, Joseph (Editor)

    1990-01-01

    This is the twenty-eighth issue of NASA's Space Life Sciences Digest. It contains abstracts of 60 journal papers or book chapters published in Russian and of 3 Soviet monographs. Selected abstracts are illustrated with figures and tables from the original. The abstracts in this issue have been identified as relevant to 20 areas of space biology and medicine. These areas include: adaptation, aviation medicine, botany, cardiovascular and respiratory systems, developmental biology, endocrinology, enzymology, equipment and instrumentation, hematology, human performance, immunology, life support systems, mathematical modeling, musculoskeletal system, neurophysiology, personnel selection, psychology, radiobiology, reproductive system, and space medicine.

  15. A Comparative Analysis of Life-Cycle Assessment Tools for End-of-Life Materials Management Systems

    EPA Science Inventory

    We identified and evaluated five life-cycle assessment tools that community decision makers can use to assess the environmental and economic impacts of end-of-life (EOL) materials management options. The tools evaluated in this report are waste reduction mode (WARM), municipal s...

  16. Intelligent life in cosmology

    NASA Astrophysics Data System (ADS)

    Tipler, Frank J.

    2003-04-01

    I shall present three arguments for the proposition that intelligent life is very rare in the universe. First, I shall summarize the consensus opinion of the founders of the modern synthesis (Simpson, Dobzhanski and Mayr) that the evolution of intelligent life is exceedingly improbable. Secondly, I shall develop the Fermi paradox: if they existed, they would be here. Thirdly, I shall show that if intelligent life were too common, it would use up all available resources and die out. But I shall show that the quantum mechanical principle of unitarity (actually a form of teleology!) requires intelligent life to survive to the end of time. Finally, I shall argue that, if the universe is indeed accelerating, then survival to the end of time requires that intelligent life, though rare, to have evolved several times in the visible universe. I shall argue that the acceleration is a consequence of the excess of matter over antimatter in the universe. I shall suggest experiments to test these claims.

  17. Comets and life

    NASA Technical Reports Server (NTRS)

    Oro, J.; Berry, J. M.

    1987-01-01

    Some of the chemical species which have been detected in comets include H2O, HCN, CH3CN, CO, CO2, NH3, CS, C2 and C3. All of these have also been detected in the interstellar medium, indicating a probable relationship between interstellar dust and gas clouds and comets. Laboratory experiments carried out with different mixtures of these molecules give rise to the formation of the biochemical compounds which are necessary for life, such as amino acids, purines, pyrimidines, monosaccharides, etc. However, in spite of suggestions to the contrary, the presence of life in comets is unlikely. On the other hand, the capture of cometary matter by the primitive earth is considered essential for the development of life on this planet. The amount of cometary carbon-containing matter captured by the earth, as calcualted by different authors, is several times larger than the total amount of organic matter present in the biosphere (10 to the 18th g). The major classes of reactions which were probably involved in the formation of key biochemical compounds are discussed. The tentative conclusions are that: (1) comets played a predominant role in the emergence of life on earth, and (2) they are the cosmic connection with extraterrestrial life.

  18. Towards the bibliography of life

    PubMed Central

    King, David; Morse, David R.; Willis, Alistair; Dil, Anton

    2011-01-01

    Abstract This paper discusses how we intend to take forward the vision of a Bibliography of Life in the ViBRANT project. The underlying principle of the Bibliography is to provide taxonomists and others with a freely accessible bibliography covering the whole of life. Such a bibliography has been achieved for specific study areas within taxonomy, but not for “life” as a whole. The creation of such a comprehensive tool has been hindered by various social and technical issues. The social concerns focus on the willingness of users to contribute to the Bibliography. The technical concerns relate to the architecture required to deliver the Bibliography. These issues are discussed in the paper and approaches to addressing them within the ViBRANT project are described, to demonstrate how we can now seriously consider building a Bibliography of Life. We are particularly interested in the potential of the resulting tool to improve the quality of bibliographic references. Through analysing the large number of references in the Bibliography we will be able to add metadata by resolving known issues such as geographical name variations. This should result in a tool that will assist taxonomists in two ways. Firstly, it will be easier for them to discover relevant literature, especially pre-digital literature; and secondly, it will be easier for them to identify the canonical form for a citation The paper also covers related issues relevant to building the tool in ViBRANT, including implementation and copyright, with suggestions as to how we could address them. PMID:22207811

  19. Practical Life: The Keystone of Life, Culture, and Community

    ERIC Educational Resources Information Center

    Ramani, Uma

    2013-01-01

    Uma Ramani's characterization of practical life is philosophical and anthropological, suggesting that "human history is the story of the evolution of our practical life activities." Practical life is a collaborative activity that creates community and culture. One's adaptation to life through the daily work of ordering our environment…

  20. Predicting Later-Life Outcomes of Early-Life Exposures

    EPA Science Inventory

    Background: In utero exposure of the fetus to a stressor can lead to disease in later life. Epigenetic mechanisms are likely mediators of later-life expression of early-life events.Objectives: We examined the current state of understanding of later-life diseases resulting from ea...

  1. Life Out of Chaos

    NASA Technical Reports Server (NTRS)

    Arrhenius, Gustaf

    2002-01-01

    Doctinary overlays on the definition of life can effectively be avoided by focusing discussion on microorganisms, their vital processes, and their genetic pedigree. To reach beyond these present and highly advanced forms of life and to inquire about its origin it is necessary to consider the requirements imposed by the environment. These requirements include geophysically and geochemically acceptable conjectures for the generation of source compounds, their concentration from dilute solution, and their selective combination into functional biomolecules. For vital function these macromolecules require programming in the form of specific sequence motifs. This critical programming constitutes the scientifically least understood process in the origin of life. Once this stage has been surpassed the laws of Darwinian evolution can operate in ways that are understood and experimentally demonstrated.

  2. Life in the Ice

    NASA Technical Reports Server (NTRS)

    Allen, C. C.; Wainwright, N. R.; Grasby, S. E.; Harvey, R. P.

    2003-01-01

    The current Martian surface environment is extremely hostile to any known form of life. The combination of subfreezing temperature, low atmospheric pressure and high ultraviolet flux, combined with desiccated and possibly oxidizing soil, could destroy even the hardiest microorganisms. The Viking biology experiments are generally interpreted to indicate that the surface of Mars is currently devoid of life and organic molecules at the part-per-billion level. Speculation on the possibility of extant or preserved microbial life on Mars thus centers on refuges in some manner protected from the current surface environment, either in space or time. Terrestrial analogs include hydrothermal systems, lakes, caves and subsurface aquifers as well as more clement conditions in the distant past. We are examining the evidence for microbiology in Earth's glaciated polar regions as analogs to the polar caps of Mars. This research concerns the detection of microorganisms or their preserved remains at the surface and within polar glacial ice.

  3. Life sciences accomplishments

    NASA Technical Reports Server (NTRS)

    1985-01-01

    From its inception, the main charter of Life Sciences has been to define biomedical requirements for the design and development of spacecraft systems and to participate in NASA's scientific exploration of the universe. The role of the Life Sciences Division is to: (1) assure the health, well being and productivity of all individuals who fly in space; (2) study the origin, evolution, and distribution of life in the universe; and (3) to utilize the space environment as a tool for research in biology and medicine. The activities, programs, and accomplishments to date in the efforts to achieve these goals are detailed and the future challenges that face the division as it moves forward from the shuttle era to a permanent manned presence in space space station's are examined.

  4. Advanced Life Support Systems

    NASA Technical Reports Server (NTRS)

    Barta, Daniel J.

    2004-01-01

    This presentation is planned to be a 10-15 minute "catalytic" focused presentation to be scheduled during one of the working sessions at the TIM. This presentation will focus on Advanced Life Support technologies key to future human Space Exploration as outlined in the Vision, and will include basic requirements, assessment of the state-of-the-art and gaps, and include specific technology metrics. The presentation will be technical in character, lean heavily on data in published ALS documents (such as the Baseline Values and Assumptions Document) but not provide specific technical details or build to information on any technology mentioned (thus the presentation will be benign from an export control and a new technology perspective). The topics presented will be focused on the following elements of Advanced Life Support: air revitalization, water recovery, waste management, thermal control, habitation systems, food systems and bioregenerative life support.

  5. Design Rules for Life Support Systems

    NASA Technical Reports Server (NTRS)

    Jones, Harry

    2002-01-01

    This paper considers some of the common assumptions and engineering rules of thumb used in life support system design. One general design rule is that the longer the mission, the more the life support system should use recycling and regenerable technologies. A more specific rule is that, if the system grows more than half the food, the food plants will supply all the oxygen needed for the crew life support. There are many such design rules that help in planning the analysis of life support systems and in checking results. These rules are typically if-then statements describing the results of steady-state, "back of the envelope," mass flow calculations. They are useful in identifying plausible candidate life support system designs and in rough allocations between resupply and resource recovery. Life support system designers should always review the design rules and make quick steady state calculations before doing detailed design and dynamic simulation. This paper develops the basis for the different assumptions and design rules and discusses how they should be used. We start top-down, with the highest level requirement to sustain human beings in a closed environment off Earth. We consider the crew needs for air, water, and food. We then discuss atmosphere leakage and recycling losses. The needs to support the crew and to make up losses define the fundamental life support system requirements. We consider the trade-offs between resupplying and recycling oxygen, water, and food. The specific choices between resupply and recycling are determined by mission duration, presence of in-situ resources, etc., and are defining parameters of life support system design.

  6. Reactor service life extension program

    SciTech Connect

    Caskey, G.R.; Sindelar, R.L.; Ondrejcin, R.S.; Baumann, E.W.

    1990-01-01

    A review of the Savannah River Site production reactor systems was initiated in 1980 and led to implementation of the Reactor Materials Program in 1984 to assess reactor safety and reactor service life. The program evaluated performance of the reactor tanks, primary coolant piping, and thermal shields, components of welded construction that were fabricated from Type 304 stainless steel. The structural integrity analysis of the primary coolant system has shown that the pressure boundary is not susceptible to gross rupture, including a double ended guillotine break or equivalent large area bank. Residual service life is potentially limited by two material degradation modes, irradiation damage and intergranular stress corrosion cracking. Analysis of the structural integrity of the tanks and piping has shown that continued safe operation of the reactors for several additional decades is not limited by the material performance of the primary coolant system. Although irradiation damage has not degraded material behavior to an unacceptable level, past experience has revealed serious difficulties with repair welding on irradiated stainless steel. Stress corrosion can be mitigated by newly identified limits on impurity concentrations in the coolant water and by stress mitigation of weld residual stresses. Work continues in several areas: the effects of helium on mechanical behavior of irradiated stainless steel; improved weld methods for piping and the reactor tanks; and a surveillance program to track irradiation effects on the tank walls.

  7. Reactor service life extension program

    SciTech Connect

    Caskey, G.R.; Sindelar, R.L.; Ondrejcin, R.S.; Baumann, E.W.

    1990-12-31

    A review of the Savannah River Site production reactor systems was initiated in 1980 and led to implementation of the Reactor Materials Program in 1984 to assess reactor safety and reactor service life. The program evaluated performance of the reactor tanks, primary coolant piping, and thermal shields, components of welded construction that were fabricated from Type 304 stainless steel. The structural integrity analysis of the primary coolant system has shown that the pressure boundary is not susceptible to gross rupture, including a double ended guillotine break or equivalent large area bank. Residual service life is potentially limited by two material degradation modes, irradiation damage and intergranular stress corrosion cracking. Analysis of the structural integrity of the tanks and piping has shown that continued safe operation of the reactors for several additional decades is not limited by the material performance of the primary coolant system. Although irradiation damage has not degraded material behavior to an unacceptable level, past experience has revealed serious difficulties with repair welding on irradiated stainless steel. Stress corrosion can be mitigated by newly identified limits on impurity concentrations in the coolant water and by stress mitigation of weld residual stresses. Work continues in several areas: the effects of helium on mechanical behavior of irradiated stainless steel; improved weld methods for piping and the reactor tanks; and a surveillance program to track irradiation effects on the tank walls.

  8. Only six kingdoms of life.

    PubMed

    Cavalier-Smith, Thomas

    2004-06-22

    There are many more phyla of microbes than of macro-organisms, but microbial biodiversity is poorly understood because most microbes are uncultured. Phylogenetic analysis of rDNA sequences cloned after PCR amplification of DNA extracted directly from environmental samples is a powerful way of exploring our degree of ignorance of major groups. As there are only five eukaryotic kingdoms, two claims using such methods for numerous novel 'kingdom-level' lineages among anaerobic eukaryotes would be remarkable, if true. By reanalysing those data with 167 known species (not merely 8-37), I identified relatives for all 8-10 'mysterious' lineages. All probably belong to one of five already recognized phyla (Amoebozoa, Cercozoa, Apusozoa, Myzozoa, Loukozoa) within the basal kingdom Protozoa, mostly in known classes, sometimes even in known orders, families or genera. This strengthens the idea that the ancestral eukaryote was a mitochondrial aerobe. Analogous claims of novel bacterial divisions or kingdoms may reflect the weak resolution and grossly non-clock-like evolution of ribosomal rRNA, not genuine phylum-level biological disparity. Critical interpretation of environmental DNA sequences suggests that our overall picture of microbial biodiversity at phylum or division level is already rather good and comprehensive and that there are no uncharacterized kingdoms of life. However, immense lower-level diversity remains to be mapped, as does the root of the tree of life. PMID:15306349

  9. Only six kingdoms of life.

    PubMed Central

    Cavalier-Smith, Thomas

    2004-01-01

    There are many more phyla of microbes than of macro-organisms, but microbial biodiversity is poorly understood because most microbes are uncultured. Phylogenetic analysis of rDNA sequences cloned after PCR amplification of DNA extracted directly from environmental samples is a powerful way of exploring our degree of ignorance of major groups. As there are only five eukaryotic kingdoms, two claims using such methods for numerous novel 'kingdom-level' lineages among anaerobic eukaryotes would be remarkable, if true. By reanalysing those data with 167 known species (not merely 8-37), I identified relatives for all 8-10 'mysterious' lineages. All probably belong to one of five already recognized phyla (Amoebozoa, Cercozoa, Apusozoa, Myzozoa, Loukozoa) within the basal kingdom Protozoa, mostly in known classes, sometimes even in known orders, families or genera. This strengthens the idea that the ancestral eukaryote was a mitochondrial aerobe. Analogous claims of novel bacterial divisions or kingdoms may reflect the weak resolution and grossly non-clock-like evolution of ribosomal rRNA, not genuine phylum-level biological disparity. Critical interpretation of environmental DNA sequences suggests that our overall picture of microbial biodiversity at phylum or division level is already rather good and comprehensive and that there are no uncharacterized kingdoms of life. However, immense lower-level diversity remains to be mapped, as does the root of the tree of life. PMID:15306349

  10. Illuminating the life of GPCRs

    PubMed Central

    Böhme, Ilka; Beck-Sickinger, Annette G

    2009-01-01

    The investigation of biological systems highly depends on the possibilities that allow scientists to visualize and quantify biomolecules and their related activities in real-time and non-invasively. G-protein coupled receptors represent a family of very dynamic and highly regulated transmembrane proteins that are involved in various important physiological processes. Since their localization is not confined to the cell surface they have been a very attractive "moving target" and the understanding of their intracellular pathways as well as the identified protein-protein-interactions has had implications for therapeutic interventions. Recent and ongoing advances in both the establishment of a variety of labeling methods and the improvement of measuring and analyzing instrumentation, have made fluorescence techniques to an indispensable tool for GPCR imaging. The illumination of their complex life cycle, which includes receptor biosynthesis, membrane targeting, ligand binding, signaling, internalization, recycling and degradation, will provide new insights into the relationship between spatial receptor distribution and function. This review covers the existing technologies to track GPCRs in living cells. Fluorescent ligands, antibodies, auto-fluorescent proteins as well as the evolving technologies for chemical labeling with peptide- and protein-tags are described and their major applications concerning the GPCR life cycle are presented. PMID:19602276

  11. A life not worth living?

    PubMed

    Paterson, Craig

    2003-01-01

    The work of Dan Brock and Helga Kuhse is typical of the current stream of thought rejecting the validity of sanctity of life appeals to instill objective inviolable worth in human life regardless of the quality of life of the patient. The context of a person's life is supremely important. In their systems life can have high value, yet the value of life can be outweighed by the force of other disvalues. The notion of quality of life has increasingly come to signify the measurement of the worth of a person's life itself. Having a life equals a personal life. Any objectivity to life resides in 'personal', 'biographical', or 'creative' life, not mere biological life. Personal life represents the minimal threshold for any objective worth. In responding to this challenge, John Finnis has argued extensively that life is an intrinsic good--a basic human good. Following from our grasp of human life as a basic incommensurable good, it cannot be practically reasonable both to affirm that (a) 'human life is a basic human good', and (b) that 'human life qua human life can be intentionally acted against to its destruction'. Yet, if the good of human life can be considered self-evident, the self-evidence of the basic human good qua good does not mean that dialectical reasoning cannot be engaged in to indirectly support the practical reasonableness of respecting the good of human life in the deliberative choices that persons make concerning their actions. It is to the use of such dialectical reasoning, supportive of the status of human life as such a basic human good, that the article is primarily concerned to draw out and articulate. PMID:15000090

  12. Autonomy: Life and Being

    NASA Astrophysics Data System (ADS)

    Williams, Mary-Anne

    This paper uses robot experience to explore key concepts of autonomy, life and being. Unfortunately, there are no widely accepted definitions of autonomy, life or being. Using a new cognitive agent architecture we argue that autonomy is a key ingredient for both life and being, and set about exploring autonomy as a concept and a capability. Some schools of thought regard autonomy as the key characteristic that distinguishes a system from an agent; agents are systems with autonomy, but rarely is a definition of autonomy provided. Living entities are autonomous systems, and autonomy is vital to life. Intelligence presupposes autonomy too; what would it mean for a system to be intelligent but not exhibit any form of genuine autonomy. Our philosophical, scientific and legal understanding of autonomy and its implications is immature and as a result progress towards designing, building, managing, exploiting and regulating autonomous systems is retarded. In response we put forward a framework for exploring autonomy as a concept and capability based on a new cognitive architecture. Using this architecture tools and benchmarks can be developed to analyze and study autonomy in its own right as a means to further our understanding of autonomous systems, life and being. This endeavor would lead to important practical benefits for autonomous systems design and help determine the legal status of autonomous systems. It is only with a new enabling understanding of autonomy that the dream of Artificial Intelligence and Artificial Life can be realized. We argue that designing systems with genuine autonomy capabilities can be achieved by focusing on agent experiences of being rather than attempting to encode human experiences as symbolic knowledge and know-how in the artificial agents we build.

  13. Women in public life.

    PubMed

    1992-01-01

    The UN Division for the Advancement of Women publication has devoted an issue to the role of women in public lie based on an analysis of women's status in industrialized countries presented in Vienna, Austria, in May 1991. Women already contribute to political life and make a difference in politics, but societal institutions and government processes have not yet adapted to this fact. Women's nongovernmental organizations promote women's interests at the governmental level, but often do not have the economic or political power as do other interests groups such as trade unions. Women often participation public life via their membership in women's organizations, community action groups, voluntary organizations, and other close to home groups. They prefer to participate in activities which are problem solving rather than institution building. These activities and groups operate outside established political institutions and are not considered as part of public and political life. Society's exclusion of women from leadership positions in public life keeps it from benefiting from the special contributions that women bring to decision making. Women show a tendency to have different leadership styles than men (e.g., ability to relate to people affected by their decisions), which are most needed for the modern world. They often do not campaign just for women's issues, but, once in office, they do tend to become more involved in women's issues. Women have affected positive changes in career and child care, often on a non-Socialist agenda, in various countries (e.g. Norway). This effect is referred to as the politics of motherhood. More access to politics and public life calls for removal of structural and situational barriers including the glass ceiling, discrimination, insufficient funds, and bearing most of the responsibility for child care. The UN women's groups has drafted a platform for interregional consultation on women's role in public life and scheduled the 4th

  14. Building the blueprint of life.

    SciTech Connect

    Henry, C. S.; Overbeek, R.; Stevens, R. L.; Fellowship for Interpretation of Genomes

    2010-07-01

    With recent breakthroughs in experimental microbiology making it possible to synthesize and implant an entire genome to create a living cell, the challenge of constructing a working blueprint for the first truly minimal synthetic organism is more important than ever. Here we review the significant progress made in the design and creation of a minimal organism. We discuss how comparative genomes, gene essentiality data, naturally small genomes, and metabolic modeling are all being applied to produce a catalogue of the biological functions essential for life. We compare the minimal gene sets from three published sources with functions identified in 13 existing gene essentiality datasets. We examine how genome-scale metabolic models have been applied to design a minimal metabolism for growth in simple and complex media. Additionally, we survey the progress of efforts to construct a minimal organism, either through implementation of combinatorial deletions in Bacillus subtilis and Escherichia coli or through the synthesis and implantation of synthetic genomes.

  15. Building the blueprint of life.

    PubMed

    Henry, Christopher; Overbeek, Ross; Stevens, Rick L

    2010-07-01

    With recent breakthroughs in experimental microbiology making it possible to synthesize and implant an entire genome to create a living cell, the challenge of constructing a working blueprint for the first truly minimal synthetic organism is more important than ever. Here we review the significant progress made in the design and creation of a minimal organism. We discuss how comparative genomes, gene essentiality data, naturally small genomes, and metabolic modeling are all being applied to produce a catalogue of the biological functions essential for life. We compare the minimal gene sets from three published sources with functions identified in 13 existing gene essentiality datasets. We examine how genome-scale metabolic models have been applied to design a minimal metabolism for growth in simple and complex media. Additionally, we survey the progress of efforts to construct a minimal organism, either through implementation of combinatorial deletions in Bacillus subtilis and Escherichia coli or through the synthesis and implantation of synthetic genomes. PMID:20665643

  16. Mid-Life Nuances and Negotiations: Narrative Maps and the Social Construction of Mid-Life in Sport and Physical Activity

    ERIC Educational Resources Information Center

    Partington, Elizabeth; Partington, Sarah; Fishwick, Lesley; Allin, Linda

    2005-01-01

    This paper adopts a narrative perspective on the study of mid-life experiences in sport. Different types of stories about sporting mid-life are identified and discussed. Drawing upon the concept of narrative mapping, the potential of these stories to serve as narrative maps for those approaching mid-life is considered. Data from an interview study…

  17. Extending bearing life

    SciTech Connect

    Boyer, D.

    1997-08-01

    Long-term bearing operation cannot be achieved unless proper handling, storage, installation, and maintenance procedures are followed. These factors can shorten--sometimes drastically--expected bearing service life. Failures are generally related to improper lubrication or installation and induced conditions. Most major bearing manufacturers offer technical assistance in inspection, evaluation, and reporting on bearings which have failed in service. Actual percentages associated with each failure category vary, depending on the source, but generally they are 70% from lubrication and installation, 20% from induced factors, and 10% from reaching their fatigue limit or design life. The paper describes lubricant-related failures and procedures for the correct handling, storage, installation, and maintenance.

  18. The planets and life.

    NASA Technical Reports Server (NTRS)

    Young, R. S.

    1971-01-01

    It is pointed out that planetary exploration is not simply a program designed to detect life on another planet. A planet similar to earth, such as Mars, when studied for evidence as to why life did not arise, may turn out to be scientifically more important than a planet which has already produced a living system. Of particular interest after Mars are Venus and Jupiter. Jupiter has a primitive atmosphere which may well be synthesizing organic molecules today. Speculations have been made concerning the possibility of a bio-zone in the upper atmosphere of Venus.

  19. Spacelab Life Sciences-1

    NASA Technical Reports Server (NTRS)

    Dalton, Bonnie P.; Jahns, Gary; Meylor, John; Hawes, Nikki; Fast, Tom N.; Zarow, Greg

    1995-01-01

    This report provides an historical overview of the Spacelab Life Sciences-1 (SLS-1) mission along with the resultant biomaintenance data and investigators' findings. Only the nonhuman elements, developed by Ames Research Center (ARC) researchers, are addressed herein. The STS-40 flight of SLS-1, in June 1991, was the first spacelab flown after 'return to orbit', it was also the first spacelab mission specifically designated as a Life Sciences Spacelab. The experiments performed provided baseline data for both hardware and rodents used in succeeding missions.

  20. Bioregenerative life support

    NASA Technical Reports Server (NTRS)

    Taylor, Bill

    1990-01-01

    Bioregenerative life support systems utilize plant growth for food, water, and atmosphere revitalization. Simulation studies of a simplified model are presented that suggest survivability in the face of partial plant growth chamber failure. Simulation studies demonstrate the potential for a bioregenerative life support system on an extended mission. In addition to robustness and survivability in terms of the food supply, the plant growth chamber produces exactly the right amount of oxygen for the crew's metabolic needs. The amount of water taken up by the plants during food production is balanced by the crew's metabolic water production.

  1. Coating Life Prediction

    NASA Technical Reports Server (NTRS)

    Nesbitt, J. A.; Gedwill, M. A.

    1984-01-01

    Hot-section gas-turbine components typically require some form of coating for oxidation and corrosion protection. Efficient use of coatings requires reliable and accurate predictions of the protective life of the coating. Currently engine inspections and component replacements are often made on a conservative basis. As a result, there is a constant need to improve and develop the life-prediction capability of metallic coatings for use in various service environments. The purpose of this present work is aimed at developing of an improved methodology for predicting metallic coating lives in an oxidizing environment and in a corrosive environment.

  2. Quantum Game of Life

    NASA Astrophysics Data System (ADS)

    Glick, Aaron; Carr, Lincoln; Calarco, Tommaso; Montangero, Simone

    2014-03-01

    In order to investigate the emergence of complexity in quantum systems, we present a quantum game of life, inspired by Conway's classic game of life. Through Matrix Product State (MPS) calculations, we simulate the evolution of quantum systems, dictated by a Hamiltonian that defines the rules of our quantum game. We analyze the system through a number of measures which elicit the emergence of complexity in terms of spatial organization, system dynamics, and non-local mutual information within the network. Funded by NSF

  3. Identifying Fishes through DNA Barcodes and Microarrays

    PubMed Central

    Kochzius, Marc; Seidel, Christian; Antoniou, Aglaia; Botla, Sandeep Kumar; Campo, Daniel; Cariani, Alessia; Vazquez, Eva Garcia; Hauschild, Janet; Hervet, Caroline; Hjörleifsdottir, Sigridur; Hreggvidsson, Gudmundur; Kappel, Kristina; Landi, Monica; Magoulas, Antonios; Marteinsson, Viggo; Nölte, Manfred; Planes, Serge; Tinti, Fausto; Turan, Cemal; Venugopal, Moleyur N.; Weber, Hannes; Blohm, Dietmar

    2010-01-01

    Background International fish trade reached an import value of 62.8 billion Euro in 2006, of which 44.6% are covered by the European Union. Species identification is a key problem throughout the life cycle of fishes: from eggs and larvae to adults in fisheries research and control, as well as processed fish products in consumer protection. Methodology/Principal Findings This study aims to evaluate the applicability of the three mitochondrial genes 16S rRNA (16S), cytochrome b (cyt b), and cytochrome oxidase subunit I (COI) for the identification of 50 European marine fish species by combining techniques of “DNA barcoding” and microarrays. In a DNA barcoding approach, neighbour Joining (NJ) phylogenetic trees of 369 16S, 212 cyt b, and 447 COI sequences indicated that cyt b and COI are suitable for unambiguous identification, whereas 16S failed to discriminate closely related flatfish and gurnard species. In course of probe design for DNA microarray development, each of the markers yielded a high number of potentially species-specific probes in silico, although many of them were rejected based on microarray hybridisation experiments. None of the markers provided probes to discriminate the sibling flatfish and gurnard species. However, since 16S-probes were less negatively influenced by the “position of label” effect and showed the lowest rejection rate and the highest mean signal intensity, 16S is more suitable for DNA microarray probe design than cty b and COI. The large portion of rejected COI-probes after hybridisation experiments (>90%) renders the DNA barcoding marker as rather unsuitable for this high-throughput technology. Conclusions/Significance Based on these data, a DNA microarray containing 64 functional oligonucleotide probes for the identification of 30 out of the 50 fish species investigated was developed. It represents the next step towards an automated and easy-to-handle method to identify fish, ichthyoplankton, and fish products. PMID

  4. Identifying natural flow regimes using fish communities

    NASA Astrophysics Data System (ADS)

    Chang, Fi-John; Tsai, Wen-Ping; Wu, Tzu-Ching; Chen, Hung-kwai; Herricks, Edwin E.

    2011-10-01

    SummaryModern water resources management has adopted natural flow regimes as reasonable targets for river restoration and conservation. The characterization of a natural flow regime begins with the development of hydrologic statistics from flow records. However, little guidance exists for defining the period of record needed for regime determination. In Taiwan, the Taiwan Eco-hydrological Indicator System (TEIS), a group of hydrologic statistics selected for fisheries relevance, is being used to evaluate ecological flows. The TEIS consists of a group of hydrologic statistics selected to characterize the relationships between flow and the life history of indigenous species. Using the TEIS and biosurvey data for Taiwan, this paper identifies the length of hydrologic record sufficient for natural flow regime characterization. To define the ecological hydrology of fish communities, this study connected hydrologic statistics to fish communities by using methods to define antecedent conditions that influence existing community composition. A moving average method was applied to TEIS statistics to reflect the effects of antecedent flow condition and a point-biserial correlation method was used to relate fisheries collections with TEIS statistics. The resulting fish species-TEIS (FISH-TEIS) hydrologic statistics matrix takes full advantage of historical flows and fisheries data. The analysis indicates that, in the watersheds analyzed, averaging TEIS statistics for the present year and 3 years prior to the sampling date, termed MA(4), is sufficient to develop a natural flow regime. This result suggests that flow regimes based on hydrologic statistics for the period of record can be replaced by regimes developed for sampled fish communities.

  5. Seeing the Chemistry around Me--Helping Students Identify the Relevance of Chemistry to Everyday Life

    ERIC Educational Resources Information Center

    Moore, Tracy Lynn

    2012-01-01

    The study attempted to determine whether the use of a series of reading and response assignments decreased students' perceptions of chemistry difficulty and enhanced students' perceptions of the relevance of chemistry in their everyday lives. Informed consent volunteer students enrolled in General Chemistry II at a community college in…

  6. The Use of Narratives to Identify Characteristics Leading to a Productive Life following Acquired Brain Injury

    ERIC Educational Resources Information Center

    Fraas, Michael R.; Calvert, Margaret

    2009-01-01

    Purpose: To determine the factors leading to successful recovery and productive lifestyles after acquired brain injury (ABI). Method: Qualitative investigation examined semistructured interviews of 31 survivors of ABI. Thematic analysis followed a phenomenological approach and revealed 4 major themes and 28 subthemes in the interviews. Four…

  7. Family Life Education for Young Inner-City Teens: Identifying Needs.

    ERIC Educational Resources Information Center

    Herz, Elicia J.; Reis, Janet S.

    1987-01-01

    Sexual decision making, perceptions of responsibility for birth control and pregnancy, and knowledge of contraception and the consequences of teenage pregnancy were assessed among 251 high-risk seventh- and eighth-grade Black, inner-city adolescents to determine these young peoples' need for information. (Author/LMO)

  8. Life in the Universe

    NASA Astrophysics Data System (ADS)

    2001-10-01

    Live Webcast from Europe's Leading Research Organisations Summary Is there life elsewhere in the Universe? Are we alone? These questions have always fascinated humanity and for more than 50 years, physicists, biologists, chemists, cosmologists, astronomers and other scientists have worked tirelessly to answer these fundamental questions. And now this November via webcast, all the world will have the opportunity to see and hear the latest news on extraterrestrial life from the most prestigious research centers and how for the past three months, European students have had the chance to jump into the scientists' shoes and explore these questions for themselves. The event is being sponsored by the European Organisation for Nuclear Research (CERN) , the European Space Agency (ESA) and the European Southern Observatory (ESO) , in cooperation with the European Molecular Biology Laboratory (EMBL) and the European Synchrotron Radiation Facility (ESRF) and the European Association for Astronomy Education (EAAE). "Life in the Universe" is being mounted in collaboration with the Research Directorate-General of the European Commission for the European Week of Science and Technology in November 2001 . "Life in the Universe" competitions are already underway in 23 European countries to find the best projects from school students between 14 and 18. Two winning teams from each country will be invited to a final event at CERN in Geneva on 8-11 November 2001 to present their projects and discuss them with a panel of International Experts at a special three-day event. They will also compete for the "Super Prize" - a free visit to ESA's and ESO's research and technology facilities at Kourou and Paranal in South America. Students participating in the programme are encouraged to present their views on extraterrestrial life creatively. The only requirement is that the views be based upon scientific evidence. Many projects are being submitted just now - among them are scientific essays

  9. Identifying, studying and making good use of macromolecular crystals

    PubMed Central

    Calero, Guillermo; Cohen, Aina E.; Luft, Joseph R.; Newman, Janet; Snell, Edward H.

    2014-01-01

    Structural biology has contributed tremendous knowledge to the understanding of life on the molecular scale. The Protein Data Bank, a depository of this structural knowledge, currently contains over 100 000 protein structures, with the majority stemming from X-ray crystallography. As the name might suggest, crystallography requires crystals. As detectors become more sensitive and X-ray sources more intense, the notion of a crystal is gradually changing from one large enough to embellish expensive jewellery to objects that have external dimensions of the order of the wavelength of visible light. Identifying these crystals is a prerequisite to their study. This paper discusses developments in identifying these crystals during crystallization screening and distinguishing them from other potential outcomes. The practical aspects of ensuring that once a crystal is identified it can then be positioned in the X-ray beam for data collection are also addressed. PMID:25084371

  10. Identifying, studying and making good use of macromolecular crystals.

    PubMed

    Calero, Guillermo; Cohen, Aina E; Luft, Joseph R; Newman, Janet; Snell, Edward H

    2014-08-01

    Structural biology has contributed tremendous knowledge to the understanding of life on the molecular scale. The Protein Data Bank, a depository of this structural knowledge, currently contains over 100,000 protein structures, with the majority stemming from X-ray crystallography. As the name might suggest, crystallography requires crystals. As detectors become more sensitive and X-ray sources more intense, the notion of a crystal is gradually changing from one large enough to embellish expensive jewellery to objects that have external dimensions of the order of the wavelength of visible light. Identifying these crystals is a prerequisite to their study. This paper discusses developments in identifying these crystals during crystallization screening and distinguishing them from other potential outcomes. The practical aspects of ensuring that once a crystal is identified it can then be positioned in the X-ray beam for data collection are also addressed. PMID:25084371

  11. [Social representations of elders' quality of life].

    PubMed

    Silva, Luípa Michele; Silva, Antonia Oliveira; Tura, Luiz Fernando Rangel; Moreira, Maria Adelaide Silva Paredes; Rodrigues, Rosalina Aparecida Partezani; Marques, Maria do Céu

    2012-03-01

    This study aimed to identify elders' social representations of quality of life. This is an exploratory study with a sample of 240 elders, of both sexes. For data collection we used a Free Association Test with Words, using the inductive stimulus 'quality of life" and sociodemographic variables. The interviews were analyzed with the software Alceste. Of the 240 studied eslders, 167 were women, with the dominant age from 60 to 69 years, income between two and three minimum wages, most of the married and with catholicism as the predominant religion. The results from Alceste pointed towards seven hierarchical classes: accessibility, work, activity, support affection, care and interactions. Social representations of quality of life by elders can support professionals in understanding the adhesion to preventive practices for the elderly and in strengthening policies directed to this population. PMID:22737803

  12. Optimization of life cycle management costs

    SciTech Connect

    Banerjee, A.K.

    1994-12-31

    As can be seen from the case studies, a LCM program needs to address and integrate, in the decision process, technical, political, licensing, remaining plant life, component replacement cycles, and financial issues. As part of the LCM evaluations, existing plant programs, ongoing replacement projects, short and long-term operation and maintenance issues, and life extension strategies must be considered. The development of the LCM evaluations and the cost benefit analysis identifies critical technical and life cycle cost parameters. These {open_quotes}discoveries{close_quotes} result from the detailed and effective use of a consistent, quantifiable, and well documented methodology. The systematic development and implementation of a plant-wide LCM program provides for an integrated and structured process that leads to the most practical and effective recommendations. Through the implementation of these recommendations and cost effective decisions, the overall power production costs can be controlled and ultimately lowered.

  13. Fibromyalgia, Spirituality, Coping and Quality of Life.

    PubMed

    Biccheri, Eliane; Roussiau, Nicolas; Mambet-Doué, Constance

    2016-08-01

    The aim of this study is to identify the impact of spirituality on coping strategies and on the quality of life of fibromyalgia patients. The study was carried out on 590 people suffering from fibromyalgia. The data were collected with the French version of the WCC-R (The Ways of Coping Checklist: Cousson et al. 1996), the questionnaire of spirituality (Evaluation de La Spiritualité: Renard and Roussiau, 2016) and Diener's Satisfaction with Life Scale questionnaire, translated into French (Blais et al. 1989). An analysis carried out with the software SPSS and Hayes' models showed that both problem-focused coping and coping through social support seeking are mediating variables that enable an indirect link between spirituality and quality of life. PMID:26922751

  14. USSR Space Life Sciences Digest, issue 14

    NASA Technical Reports Server (NTRS)

    Hooke, Lydia Razran; Teeter, Ronald; Radtke, Mike; Rowe, Joseph

    1988-01-01

    This is the fourteenth issue of NASA's USSR Space Life Sciences Digest. It contains abstracts of 32 papers recently published in Russian language periodicals and bound collections and of three new Soviet monographs. Selected abstracts are illustrated with figures and tables from the original. Also included is a review of a recent Soviet conference on Space Biology and Aerospace Medicine. Current Soviet life sciences titles available in English are cited. The materials included in this issue have been identified as relevant to the following areas of aerospace medicine and space biology: adaptation, biological rhythms, body fluids, botany, cardiovascular and respiratory systems, developmental biology, endocrinology, enzymology, equipment and instrumentation, gastrointestinal systems, habitability and environment effects, human performance, immunology, life support systems, mathematical modeling, metabolism, musculoskeletal system, neurophysiology, nutrition, operational medicine, perception, personnel selection, psychology, radiobiology, and space biology and medicine.

  15. USSR Space Life Sciences Digest, issue 11

    NASA Technical Reports Server (NTRS)

    Hooke, Lydia Razran (Editor); Radtke, Mike (Editor); Radtke, Mike (Editor); Radtke, Mike (Editor); Radtke, Mike (Editor); Radtke, Mike (Editor)

    1987-01-01

    This is the eleventh issue of NASA's USSR Space Life Sciences Digest. It contains abstracts of 54 papers recently published in Russian language periodicals and bound collections and of four new Soviet monographs. Selected abstracts are illustrated. Additional features include the translation of a paper presented in Russian to the United Nations, a review of a book on space ecology, and report of a conference on evaluating human functional capacities and predicting health. Current Soviet Life Sciences titles available in English are cited. The materials included in this issue have been identified as relevant to 30 areas of aerospace medicine and space biology. These areas are: adaptation, aviation physiology, biological rhythms, biospherics, body fluids, botany, cardiovascular and respiratory systems, cosmonaut training, developmental biology, endocrinology, enzymology, equipment and instrumentation, gastrointestinal systems, group dynamics, genetics, hematology, human performance, immunology, life support systems, mathematical modeling, metabolism, microbiology, musculoskeletal system, neurophysiology, nutrition, operational medicine, perception, personnel selection, psychology, and radiobiology.

  16. Lungfish and Life.

    ERIC Educational Resources Information Center

    Flannery, Maura C.

    1997-01-01

    Discusses the writings of Homer W. Smith, a physiologist who wrote novels, histories of religion, textbooks, and a book on the kidney for the general reader. Smith's writing skills remind students that biologists are as multidimensional as the rest of the population. Smith shows that all parts of life are interrelated as they enrich and shed light…

  17. Investigations Into Life Science.

    ERIC Educational Resources Information Center

    Mentzer, Dean Samuel

    This laboratory manual, containing 44 exercises, is intended to be used as part of an audio-tutorial approach to laboratory work in a life-science course for student nurses. Exercises include basic techniques of miscroscopy, microbiology, electrophysiology, routine biochemical analyses of blood and urine, and microscopic examination of prepared…

  18. Two-dimensional life?

    PubMed Central

    de Duve, Christian; Miller, Stanley L.

    1991-01-01

    A model [Wächtershäuser, G. (1988) Microbiol. Rev. 52, 452-484], according to which life started in the form of a monomolecular layer of interacting anionic metabolites electrostatically bound to a positively charged surface, is examined critically. The model raises a number of thermodynamic and kinetic difficulties. PMID:11538487

  19. Empowerment for Later Life.

    ERIC Educational Resources Information Center

    Myers, Jane E.

    This monograph purports that American society limits the behavior of older individuals based on the arbitrary criterion of chronological age and proposes the concept of empowerment--gaining a sense of personal power or control over over's life--as the antidote for older persons who face devalued status as they age and the for the accompanying drop…

  20. The Residence Life Cinema.

    ERIC Educational Resources Information Center

    Dungan, Jane Fidler; Elion, Audrey; Gusmano, Phil

    1997-01-01

    Explores the implementation, results, and the limitations of the Residence Life Cinema program at the University of Memphis. Claims that such programs offer an innovative method for fostering student development by utilizing movies to stimulate affective and cognitive processes in students--processes that may not occur without a catalyst. (RJM)

  1. The Life Programming Process.

    ERIC Educational Resources Information Center

    Garner, Waunita L.

    The paper explains how Project LIFE (Language Improvement to Facilitate Education) has applied the principles of programed instruction in developing language materials for language handicapped children, especially the hearing impaired. Early strategy decisions are said to have involved obtaining a teaching machine which would be equipped with a…

  2. Chemical Origins of Life

    ERIC Educational Resources Information Center

    Fox, J. Lawrence

    1972-01-01

    Reviews ideas and evidence bearing on the origin of life. Shows that evidence to support modifications of Oparin's theories of the origin of biological constituents from inorganic materials is accumulating, and that the necessary components are readily obtained from the simple gases found in the universe. (AL)

  3. How life shaped Earth.

    PubMed

    Gross, Michael

    2015-10-01

    Earth is much more complex than all the other solar system objects that we know. Thanks to its rich and diverse geology, our planet can offer habitats to a wide range of living species. Emerging insights suggest that this is not just a happy coincidence, but that life itself has in many ways helped to shape the planet. PMID:26726334

  4. Life Skills Project

    ERIC Educational Resources Information Center

    Schwartz, Sunny

    2005-01-01

    In this article, the author describes the San Francisco Sheriff's Department (SFSD) Life Skills for Prisoners Program. The program was designed to enhance and expand the Resolve to Stop the Violence Project, which had operated successfully for three years in the San Francisco County Jail as a restorative justice program. The mission of SFSD is to…

  5. Bringing Psychology to Life.

    ERIC Educational Resources Information Center

    McAdam, Dale

    1987-01-01

    Describes a set of exercises called Bringing Psychology to Life (BPL), which is designed to engage introductory psychology students in learning course and textbook content by having them develop psychological explanations for events in their lives. Maintains that BPL is an excellent icebreaker for graduate teaching assistants and a vehicle for…

  6. It's a Salmon's Life!

    ERIC Educational Resources Information Center

    French, M. Jenice; Skochdopole, Laura Downey

    1998-01-01

    Describes an integrated science unit to help preservice teachers gain confidence in their abilities to learn and teach science. The teachers role played being salmon as they learned about the salmon's life cycle and the difficulties salmon encounter. The unit introduced the use of investigative activities that begin with questions and end with…

  7. Alien Life Imagined

    NASA Astrophysics Data System (ADS)

    Brake, Mark

    2012-11-01

    1. Kosmos: aliens in ancient Greece; 2. The world turned upside down: Copernicanism and the voyages of discovery; 3. In Newton's train: pluralism and the system of the world; 4. Extraterrestrials in the early machine age; 5. After Darwin: the war of the worlds; 6. Einstein's sky: life in the new universe; 7. Ever since SETI: astrobiology in the space age; References; Index.

  8. Life after the Principalship

    ERIC Educational Resources Information Center

    Schmidt, Laurel

    2009-01-01

    Sixty-eight percent of people who are approaching retirement age report that they intend to work full time or part time after retirement, mostly because they want to. With today's life span stretching to 80 years and beyond, turning 60 is no longer an end-stage event. Instead, it is the beginning of a new developmental phase. This article…

  9. A life of cycles.

    PubMed

    Pycock, Jonathan

    2015-03-01

    Jonathan Pycock is one of three equine claims consultants with the Veterinary Defence Society. His career in equine reproduction, and lecturing on the same topic, has given him the opportunity to work and travel widely, and ensure his work/life balance stays in sync. PMID:25748201

  10. Chemicals in Everyday Life.

    ERIC Educational Resources Information Center

    Seymour, Raymond B.

    1987-01-01

    Discusses the dependencies of people on chemicals in various aspects of life. Describes some of the natural and synthetic chemicals currently used in food production, clothing, shelter, travel and exploration, sports and recreation, ventilation, heating and cooling, communications, decoration, sanitation, and education. (TW)

  11. Languages for Life?

    ERIC Educational Resources Information Center

    Watters, Kate

    2007-01-01

    The strategy of the Department for Education and Skills'(DfES) 2002 strategy document, "Languages for All: Languages for Life" called for improving the quality of language teaching and learning; enhancing qualifications and credit recognition arrangements; and increasing demand for language learning. This principle was to extends to adult…

  12. Exploring for Martian Life

    NASA Astrophysics Data System (ADS)

    Farmer, Jack D.

    1997-04-01

    During the coming decade, robotic field science will play a fundamental role in advancing our understanding of the history of Mars. In particular, capable rovers are needed to survey a broad array of Martian rock types for in situ mineralogy and chemistry as a basis for interpreting globally-distributed remote sensing data obtained from orbit. The interplay between orbital and landed science will be fundamental in selecting sites for future missions aimed at exploring the ancient rock record for evidence of A) past life or prebiotic chemistry, B) the volatile and climate history of Mars, and C) materials for in situ resource utilization. The recent suggestion of evidence for life in the Martian meteorite, ALH84001 (McKay, D.S., E.K. Gibson, K.L. Thomas-Keprta, H. Vali, C.S. Romanek, S.J. Clemett, X.D.F. Chillier, C.R. Maechling, R.N. Zare. 1996. Search for past life on Mars: Possible relic biogenic activity in Martian meteorite ALH84001. Science) 273, 924-930has placed Exobiology in a more central position in the Mars exploration (The Search for Evidence of Life on Mars. Unpublished report, Mars Expeditions Strategy Group, 1996.)

  13. Life Satisfaction of Adolescents.

    ERIC Educational Resources Information Center

    Torgoff, Irving; And Others

    The feelings and perceptions of adolescents, apart from objective indices, warrent attention from those who are concerned with adolescent development and psychological stress. There is a need for a reliable baseline measure of adolescent subjective well-being, as manifested by self-reports of life satisfaction, to which future measurements can be…

  14. Education for Interpersonal Life.

    ERIC Educational Resources Information Center

    Saunders, William S.

    1990-01-01

    Higher education does not address the central challenges of daily interpersonal life--being a parent, spouse, friend, and offspring; dealing with change, loss, sickness, death. But education can instill "tacit knowing"--knowing in the bones, prior to conceptualization or verbalization. This knowing can be imparted by great literature. (MLW)

  15. Life Change Clusters.

    ERIC Educational Resources Information Center

    Pugh, William M.; And Others

    The amount of life stress, as measured by the Schedule of Recent Experience (SRE), has been shown to be related to the onset of illness. This instrument was originally developed with a civilian population, and it became apparent that some questions were inappropriate when it was to be applied to a military population. Furthermore, it was believed…

  16. Life in the Ocean.

    ERIC Educational Resources Information Center

    NatureScope, 1988

    1988-01-01

    Focuses on what life is like in the three major regions of the ocean: (1) the sunlit surface waters; (2) the dim mid-waters; and (3) the dark ocean depths. Five activities and three pages of ocean organisms for copying are included. (Author/RT)

  17. Advanced Cardiac Life Support.

    ERIC Educational Resources Information Center

    Kirkwood Community Coll., Cedar Rapids, IA.

    This document contains materials for an advanced college course in cardiac life support developed for the State of Iowa. The course syllabus lists the course title, hours, number, description, prerequisites, learning activities, instructional units, required text, six references, evaluation criteria, course objectives by units, course…

  18. Life Sciences MIS

    NASA Technical Reports Server (NTRS)

    Dittman, R. A.; Marks, V.

    1983-01-01

    Management Information System, MIS, provides Life Sciences Projects Division at Johnson Space Center with automated system for project managment. MIS utilizes Tektronix 4027 color graphics display terminal and form-fillout capability. User interface with MIS data base is through series of forms.

  19. Life in the Galaxy

    ERIC Educational Resources Information Center

    Oliver, B. M.

    1973-01-01

    Discusses the origin of life on the basis of information about cosmic evolution, stellar alchemy, atmospheric histories, and rise and fall of civilizations. Indicates that man's contact with other civilizations in our galaxy may be made possible through studies of interstellar communication. (CC)

  20. Bringing Scientists to Life

    ERIC Educational Resources Information Center

    Casey, Peter

    2010-01-01

    In this article, the author describes how he brings scientists to life when he visits schools. Having retired from teaching Drama and Theatre Studies in Liverpool for more than thirty years, the author set up his one-man Theatre-in-Education company, Blindseer Productions, and now takes his portrayals of Darwin, Galileo and Einstein to schools…

  1. Addressing Student Life Issues.

    ERIC Educational Resources Information Center

    Kolvitz, Marcia, Ed.

    These two conference papers from the Biennial Conference on Postsecondary Education for Persons who are Deaf or Hard of Hearing focus on campus life issues for individuals with deafness or hard of hearing. The first paper, "A Customized Residence Hall Experience for Students Who Are Deaf or Hard of Hearing" (Nancy Kasinski and others), describes…

  2. Second Life, Revisited

    ERIC Educational Resources Information Center

    Bugeja, Michael J.

    2008-01-01

    An article this author wrote about avatar harassment and assault in Second Life (SL) inspired a considerable response after it was published. Perhaps the most notable reply was from Linden Lab, the company that created the virtual-reality world. In his initial essay ("The Chronicle of Higher Education," September 14, 2007; "The Education Digest,"…

  3. The Business of Life.

    ERIC Educational Resources Information Center

    Dunski, Jonathan F.

    1997-01-01

    Describes a learning game called The Business of Life that demonstrates the cellular processes of photosynthesis and respiration as business transactions. Incorporates the ideas that energy flows through ecosystems as well as through cells of individual organisms. Demonstrates the interdependence of living things and that processes at the cellular…

  4. Symposium: Student Life

    ERIC Educational Resources Information Center

    Academic Questions, 2010

    2010-01-01

    To get an inside view of campus life today, the Intercollegiate Studies Institute (whose purpose is to foster in college students an appreciation of the values that sustain a free society) was approached and asked to supply a list of their Collegiate Network editors--students who are active on their campuses, interested in the issues facing higher…

  5. Freedom Road: Colonial Life

    ERIC Educational Resources Information Center

    Auerbach, Barbara

    2010-01-01

    While historical fiction by Jean Fritz as well as titles like Robert Lawson's "Ben and Me" (1939) or "Mr. Revere and I" (1954) and Esther Forbes's "Johnny Tremain" (1943) are widely known classics that bring this period to life, recent years have yielded a wealth of new offerings--many of which are accessible picture books or read-alouds. These…

  6. LIFE-CYCLE ASSESSMENT

    EPA Science Inventory

    Life Cycle Assessment, or LCA, is an environmental accounting and mangement approach that consider all the aspects of resource use and environmental releases associated with an industrial system from cradle-to-grave. Specifically, it is a holistic view of environmental interacti...

  7. Two-dimensional life?

    NASA Technical Reports Server (NTRS)

    de Duve, C.; Miller, S. L.

    1991-01-01

    A model [Wachtershauser, G. (1988) Microbiol. Rev. 52, 452-484], according to which life started in the form of a monomolecular layer of interacting anionic metabolites electrostatically bound to a positively charged surface, is examined critically. The model raises a number of thermodynamic and kinetic difficulties.

  8. Emotions in Everyday Life

    PubMed Central

    2015-01-01

    Despite decades of research establishing the causes and consequences of emotions in the laboratory, we know surprisingly little about emotions in everyday life. We developed a smartphone application that monitored real-time emotions of an exceptionally large (N = 11,000+) and heterogeneous participants sample. People’s everyday life seems profoundly emotional: participants experienced at least one emotion 90% of the time. The most frequent emotion was joy, followed by love and anxiety. People experienced positive emotions 2.5 times more often than negative emotions, but also experienced positive and negative emotions simultaneously relatively frequently. We also characterized the interconnections between people’s emotions using network analysis. This novel approach to emotion research suggests that specific emotions can fall into the following categories 1) connector emotions (e.g., joy), which stimulate same valence emotions while inhibiting opposite valence emotions, 2) provincial emotions (e.g., gratitude), which stimulate same valence emotions only, or 3) distal emotions (e.g., embarrassment), which have little interaction with other emotions and are typically experienced in isolation. Providing both basic foundations and novel tools to the study of emotions in everyday life, these findings demonstrate that emotions are ubiquitous to life and can exist together and distinctly, which has important implications for both emotional interventions and theory. PMID:26698124

  9. Learning for Life

    ERIC Educational Resources Information Center

    Robotham, Dan

    2011-01-01

    People working in the field of education know well the positive effects adult and community learning can have on mental health and wellbeing. Participating in adult and community learning can help to widen social networks and improve life and employment chances; it makes for better general health; and can strengthen the learner's self-confidence,…

  10. Living a Literate Life

    ERIC Educational Resources Information Center

    Kazemek, Francis E.

    2004-01-01

    This article presents the personal literacy journey of the author that originated while driving through Scotland. The journey serves as one touchstone of his own personal and professional life. The author shares what he finds on "this" particular journey: (1) Particular (and often peculiar) interest; (2) Active engagement of the four language…

  11. My father's life.

    PubMed Central

    Porth, R

    1995-01-01

    Medicine has many unsung heroes, and among them are physicians who spend their careers providing medical care in remote areas. In this article, Ronald Porth remembers the life of his father, Dr. Frank Porth, who for more than 30 years provided medical care on native reserves and in rural parts of the Prairies. Images p638-a p639-a PMID:7641162

  12. Quality of Life Symposium.

    ERIC Educational Resources Information Center

    New Mexico State Univ., Las Cruces. New Mexico Environmental Inst.

    Comments, speeches, and questions delivered at the Quality of Life Symposium are compiled in these proceedings. As an exploratory session, the conference objectives were to (1) become better informed about New Mexico--its resource base, the economy, social and cultural base, and the environment; and (2) to evaluate and discuss the role of New…

  13. Biological Life Support Systems

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Session MP2 includes short reports on: (1) Crew Regenerative Life Support in Long Duration Space Missions; (2) Bioconversion Systems for Food and Water on Long Term Space Missions; (3) Novel Laboratory Approaches to Multi-purpose Aquatic Biogenerative Closed-Loop Food Production Systems; and (4) Artificial Neural Network Derived Plant Growth Models.

  14. Emotions in Everyday Life.

    PubMed

    Trampe, Debra; Quoidbach, Jordi; Taquet, Maxime

    2015-01-01

    Despite decades of research establishing the causes and consequences of emotions in the laboratory, we know surprisingly little about emotions in everyday life. We developed a smartphone application that monitored real-time emotions of an exceptionally large (N = 11,000+) and heterogeneous participants sample. People's everyday life seems profoundly emotional: participants experienced at least one emotion 90% of the time. The most frequent emotion was joy, followed by love and anxiety. People experienced positive emotions 2.5 times more often than negative emotions, but also experienced positive and negative emotions simultaneously relatively frequently. We also characterized the interconnections between people's emotions using network analysis. This novel approach to emotion research suggests that specific emotions can fall into the following categories 1) connector emotions (e.g., joy), which stimulate same valence emotions while inhibiting opposite valence emotions, 2) provincial emotions (e.g., gratitude), which stimulate same valence emotions only, or 3) distal emotions (e.g., embarrassment), which have little interaction with other emotions and are typically experienced in isolation. Providing both basic foundations and novel tools to the study of emotions in everyday life, these findings demonstrate that emotions are ubiquitous to life and can exist together and distinctly, which has important implications for both emotional interventions and theory. PMID:26698124

  15. MALAYSIAN FAMILY LIFE SURVEY

    EPA Science Inventory

    The Malaysian Family Life Surveys (MFLS) comprise a pair of surveys with partially overlapping samples, designed by RAND and administered in Peninsular Malaysia in 1976-77 (MFLS-1) and 1988-89 (MFLS-2). Each survey collected detailed current and retrospective information on famil...

  16. Life History and Identity

    ERIC Educational Resources Information Center

    Tierney, William G.

    2013-01-01

    This article uses the life history method to chronicle the challenges of a low-income, first-generation student en route to college. The paper addresses three questions: how Manuel navigates college and related topics such as roommates, family, and money; how he creates social networks; and how he works with adults such as teachers and…

  17. Second Life as Innovation

    ERIC Educational Resources Information Center

    Guder, Christopher

    2009-01-01

    In terms of exploring the status of Second Life (SL) usage in libraries, it would be useful to not only look at how and why the virtual world is being used but also how SL compares to successfully implemented innovations of the past. Comparing and contrasting the characteristics of previously accepted innovations with those of SL will help…

  18. Encaustic Still Life.

    ERIC Educational Resources Information Center

    Mathes, Len

    2002-01-01

    Presents an art lesson used in an advanced high school art class where students used the encaustic painting technique by melting wax and combining various pigments. Explains that the students painted a still-life of flowers in the style of Vincent van Gogh. (CMK)

  19. Learning for Life Transitions

    ERIC Educational Resources Information Center

    Varmecky, Jane Hyde

    2012-01-01

    Many adults return to formal learning situations to pursue lifelong learning goals because their lives are in transition from dealing with real-life problems such as divorce and re-marriage. The purpose of this study was to describe what couples learned that contributed to the success of their subsequent marriages and how they learned it. The…

  20. Health-Related Quality of Life and Quality of Sexual Life in Obese Subjects

    PubMed Central

    Di Lazzaro, Luca; Pinto, Alessandro; Migliaccio, Silvia; Lenzi, Andrea; Donini, Lorenzo M.

    2014-01-01

    The increased prevalence of obesity represents, currently, one of the major public health issues, due to its consequences on physical and psychological health status as well as on the psychosocial functioning. As defined by the World Health Organization, sexual health is “a state of physical, emotional, mental, and social well-being in relation to sexuality.” The aim of the present study was to explore the relationship between sexual life in obese subjects and quality of life, psychological status, and disability. Methods. 95 obese subjects were recruited from June 2012 to February 2013 and underwent physical examination and measures for the assessment of quality of life, sexual life, psychological status, and disability. Results. In obese subjects sexual life was related to gender, age, psychological status, disability, and quality of life. Conclusion. As obesity is a multifactorial disease, and is accompanied by multiple comorbidities, it is difficult to identify a single causative factor responsible for the impairment of sexual life in obese subjects; thus, a thorough, multidimensional evaluation including sexual function assessment should be performed in obese people. PMID:24707290

  1. Experimental methods for identifying failure mechanisms

    NASA Technical Reports Server (NTRS)

    Daniel, I. M.

    1983-01-01

    Experimental methods for identifying failure mechanisms in fibrous composites are studied. Methods to identify failure in composite materials includes interferometry, holography, fractography and ultrasonics.

  2. Exploring for Martian Life

    NASA Technical Reports Server (NTRS)

    Farmer, Jack D.; Chang, Sherwood (Technical Monitor)

    1997-01-01

    Terrestrial life appears to have arisen very quickly during late accretion, sometime between approximately 3.5 and 4.2 Ga. During this same time, liquid water appears to have been abundant at the surface of Mars and it is quite plausable that life originated there as well. We now believe that the last common ancestor of terrestrial life was a sulfur-metabolizing microbe that lived at high temperatures. Rooting of the RNA tree in thermophily probably reflects high temperature "bottle-necking" of the biosphere by giant impacts during late accretion, sometime after life had originated. If high temperature bottle-necking is a general property of early biosphere development, Martian life may have also developed in close association with hydrothermal systems. Several independent lines of evidence suggest that hydrothermal processes have played an important role during the geological history of Mars. Because hydrothermal deposits on Earth are known to capture and retain abundant microbial fossil information, they are considered prime targets in the search for an ancient Martian biosphere. An important step in planning for future landed missions to Mars is the selection of priority targets for high resolution orbital mapping. Geotectonic terranes on Mars that provide a present focus for ongoing site selection studies include channels located along the margins of impact crater melt sheets, or on the slopes of ancient Martian volcanoes, chaotic and fretted terranes where shallow subsurface heat sources are thought to have interacted with ground ice, and the floors of calderas and rifted basins. Orbital missions in 1996, 1998 and 2001 will provide opportunities for high resolution geological mapping at key sites in such terranes, as a basis for selecting targets for future landed missions for exopaleontology.

  3. United States Life Tables, 1997.

    ERIC Educational Resources Information Center

    Anderson, Robert N.

    1999-01-01

    The life tables in this report are current life tables for the United States based on age-specific death rates in 1997. Beginning with the 1997 tables, U.S. life tables have been constructed with a new methodology that is similar to that used in the decennial life tables. Life expectancy and other tables are shown for the first time for ages 85 to…

  4. Life-course typology of adults who experienced sexual violence.

    PubMed

    Draucker, Claire; Martsolf, Donna

    2010-07-01

    Two qualitative methodologies were used to develop a life-course typology of individuals who had been exposed to sexual violence. Interview narratives of 121 adult women and men who participated in qualitative study of women's and men's responses to sexual violence provided the data. The authors combined a narrative approach (holistic-content and holistic-form analysis) to describe the life courses of the participants and a qualitative person-oriented approach (cross-case analysis) to identify meaningful subgroups within the total sample. The six groups are as follows: (a) life of turmoil, (b) life of struggles, (c) diminished life, (d) taking control of life, (e), finding peace in life, and (f) getting life back to normal. This work exemplifies a promising strategy for identifying subgroups of violence-exposed individuals within a heterogeneous sample. Such a typology could aid the development of treatment approaches that consider both the substance and the structure of an individual's life course, rather than target one specific type of violence. PMID:19762554

  5. Life Course Typology of Adults Who Experienced Sexual Violence

    PubMed Central

    Draucker, Claire Burke; Martsolf, Donna S.

    2011-01-01

    Two qualitative methodologies were used to develop a life course typology of individuals who had been exposed to sexual violence. Interview narratives of 121 adult women and men who participated in qualitative study of women’s and men’s responses to sexual violence provided the data. The authors combined a narrative approach (holistic-content and holistic-form analysis) to describe the life courses of the participants and a qualitative person-oriented approach (cross-case analysis) to identify meaningful sub-groups within the total sample. The six groups are: (a) life of turmoil, (b) life of struggles, (c) diminished life, (d) taking control of life, (e), finding peace in life, and (f) getting life back to normal. This work exemplifies a promising strategy for identifying sub-groups of violence-exposed individuals within a heterogeneous sample. Such a typology could aid the development of treatment approaches that consider both the substance and the structure of an individual’s life course, rather than target one specific type of violence. PMID:19762554

  6. Reliability and extended-life potential of EBR-II

    SciTech Connect

    King, R W

    1985-01-01

    Although the longlife potential of liquid-metal-cooled reactors (LMRs) has been only partially demonstrated, many factors point to the potential for exceptionally long life. EBR-II has the opportunity to become the first LMR to achieve an operational lifetime of 30 years or more. In 1984 a study of the extended-life potential of EBR-II identified the factors that contribute to the continued successful operation of EBR-II as a power reactor and experimental facility. Also identified were factors that could cause disruptions in the useful life of the facility. Although no factors were found that would inherently limit the life of EBR-II, measures were identified that could help ensure continued plant availability. These measures include the implementation of more effective surveillance, diagnostic, and control systems to complement the inherent safety and reliability features of EBR-II. An operating lifetime of well beyond 30 years is certainly feasible.

  7. Predicting the remaining service life of concrete

    SciTech Connect

    Clifton, J.F.

    1991-11-01

    Nuclear power plants are providing, currently, about 17 percent of the U.S. electricity and many of these plants are approaching their licensed life of 40 years. The U.S. Nuclear Regulatory Commission and the Department of Energy`s Oak Ridge National Laboratory are carrying out a program to develop a methodology for assessing the remaining safe-life of the concrete components and structures in nuclear power plants. This program has the overall objective of identifying potential structural safety issues, as well as acceptance criteria, for use in evaluations of nuclear power plants for continued service. The National Institute of Standards and Technology (NIST) is contributing to this program by identifying and analyzing methods for predicting the remaining life of in-service concrete materials. This report examines the basis for predicting the remaining service lives of concrete materials of nuclear power facilities. Methods for predicting the service life of new and in-service concrete materials are analyzed. These methods include (1) estimates based on experience, (2) comparison of performance, (3) accelerated testing, (4) stochastic methods, and (5) mathematical modeling. New approaches for predicting the remaining service lives of concrete materials are proposed and recommendations for their further development given. Degradation processes are discussed based on considerations of their mechanisms, likelihood of occurrence, manifestations, and detection. They include corrosion, sulfate attack, alkali-aggregate reactions, frost attack, leaching, radiation, salt crystallization, and microbiological attack.

  8. Identifying atmospheric monitoring needs for Space Station Freedom

    NASA Technical Reports Server (NTRS)

    Casserly, Dennis M.; Russo, Dane M.

    1990-01-01

    The monitoring needs for Space Station Freedom were identified by examining: the experiences of past missions; ground based tests of proposed life support systems; a contaminant load model; metabolic production from an 8-person crew; and a fire scenario. Continuous monitoring is recommended for components critical for life support, and that intermittent analysis be provided for all agents that may exceed one-half the spacecraft maximum allowable concentration. The minimum monitoring effort recommended includes continuous monitoring for: N2, O2, CO2, CO, H2O, H2, CH4, nonmethane hydrocarbons, aromatic hydrocarbons, refrigerants, and halons. Information on over 70 compounds is presented on the rationale for monitoring the frequency of analysis, and concentration ranges.

  9. Life Sciences Accomplishments 1994

    NASA Technical Reports Server (NTRS)

    Burnell, Mary Lou (Editor)

    1993-01-01

    The NASA Life and Biomedical Sciences and Applications Division (LBSAD) serves the Nation's life sciences community by managing all aspects of U.S. space-related life sciences research and technology development. The activities of the Division are integral components of the Nation's overall biological sciences and biomedical research efforts. However, NASA's life sciences activities are unique, in that space flight affords the opportunity to study and characterize basic biological mechanisms in ways not possible on Earth. By utilizing access to space as a research tool, NASA advances fundamental knowledge of the way in which weightlessness, radiation, and other aspects of the space-flight environment interact with biological processes. This knowledge is applied to procedures and technologies that enable humans to live and work in and explore space and contributes to the health and well-being of people on Earth. The activities of the Division are guided by the following three goals: Goal 1) Use microgravity and other unique aspects of the space environment to enhance our understanding of fundamental biological processes. Goal 2) Develop the scientific and technological foundations for supporting exploration by enabling productive human presence in space for extended periods. Goal 3) Apply our unique mission personnel, facilities, and technology to improve education, the quality of life on Earth, and U.S. competitiveness. The Division pursues these goals with integrated ground and flight programs involving the participation of NASA field centers, industry, and universities, as well as interactions with other national agencies and NASA's international partners. The published work of Division-sponsored researchers is a record of completed research in pursuit of these goals. During 1993, the LBSAD instituted significant changes in its experiment solicitation and peer review processes. For the first time, a NASA Research Announcement (NRA) was released requesting

  10. Starship Life Support

    NASA Technical Reports Server (NTRS)

    Jones, Harry W.

    2009-01-01

    The design and mass cost of a starship and its life support system are investigated. The mission plan for a multi generational interstellar voyage to colonize a new planet is used to describe the starship design, including the crew habitat, accommodations, and life support. Only current technology is assumed. Highly reliable life support systems can be provided with reasonably small additional mass, suggesting that they can support long duration missions. Bioregenerative life support, growing crop plants that provide food, water, and oxygen, has been thought to need less mass than providing stored food for long duration missions. The large initial mass of hydroponics systems is paid for over time by saving the mass of stored food. However, the yearly logistics mass required to support a bioregenerative system exceeds the mass of food solids it produces, so that supplying stored dehydrated food always requires less mass than bioregenerative food production. A mixed system that grows about half the food and supplies the other half dehydrated has advantages that allow it to breakeven with stored dehydrated food in about 66 years. However, moderate increases in the hydroponics system mass to achieve high reliability, such as adding spares that double the system mass and replacing the initial system every 100 years, increase the mass cost of bioregenerative life support. In this case, the high reliability half food growing, half food supplying system does not breakeven for 389 years. An even higher reliability half and half system, with three times original system mass and replacing the system every 50 years, never breaks even. Growing food for starship life support requires more mass than providing dehydrated food, even for multigeneration voyages of hundreds of years. The benefits of growing some food may justify the added mass cost. Much more efficient recycling food production is wanted but may not be possible. A single multigenerational interstellar voyage to

  11. The medicalization of life

    PubMed Central

    Illich, Ivan

    1975-01-01

    Two contributions from Dr Ivan Illich follow. The first, in which he sets out his primary thesis of the medicalization of life, is a section from Dr Illich's book `Medical Nemesis'. (It is reprinted with the permission of the author and his publishers, Messrs Calder and Boyars.) The second is a transcript of the paper which Dr Illich read at the conference organized by the London Medical Group on iatrogenic disease. Both are ultimately addressed to the recipients of medical care, the general public, although the second paper is specifically addressed to young doctors and medical students. For Dr Illich the world is suffering from too much medical interference, and a medical edifice has been built which is one of the threats to the real life of human beings - a threat which so far has been disguised as care. PMID:809583

  12. Through Life Costing

    NASA Astrophysics Data System (ADS)

    Newnes, Linda; Mileham, A. R.; Cheung, W. M.; Goh, Y. M.

    When an innovation is launched in such a market, reliable information about the life cost of the novel product is naturally lacking. This has proven to be a key obstacle to venture capital funded cleantech companies with innovations that are conceptually proven and that deliver significant improvements to conventional alternatives, but that lack enough reference installations to provide reliable data on life costs. One way out of this dilemma that is increasingly discussed among practitioners is servitization, i.e., the notion that the owner of the innovation should be an agency that is specialised in using and maintaining the product, letting the end customer become a buyer of the product's service (such as heat) rather than the product itself.

  13. Bioenergetics and Life's Origins

    PubMed Central

    Deamer, David; Weber, Arthur L.

    2010-01-01

    Bioenergetics is central to our understanding of living systems, yet has attracted relatively little attention in origins of life research. This article focuses on energy resources available to drive primitive metabolism and the synthesis of polymers that could be incorporated into molecular systems having properties associated with the living state. The compartmented systems are referred to as protocells, each different from all the rest and representing a kind of natural experiment. The origin of life was marked when a rare few protocells happened to have the ability to capture energy from the environment to initiate catalyzed heterotrophic growth directed by heritable genetic information in the polymers. This article examines potential sources of energy available to protocells, and mechanisms by which the energy could be used to drive polymer synthesis. PMID:20182625

  14. Basic trauma life support.

    PubMed

    Werman, H A; Nelson, R N; Campbell, J E; Fowler, R L; Gandy, P

    1987-11-01

    The impact of traumatic injuries on modern society in terms of morbidity, mortality, and economic cost is enormous. Studies have shown that both advanced life support skills and rapid stabilization and transport of the trauma victim have a beneficial effect on the patient's ultimate outcome. The Basic Trauma Life Support (BTLS) course was designed to provide pre-hospital care providers with the skills necessary to provide a thorough assessment, initial resuscitation, and rapid transportation of the trauma victim. Early studies suggest that the material is easily learned by prehospital care providers and that the on-scene time for trauma cases is reduced following training in BTLS. More widespread training in BTLS may have a significant effect on the mortality and morbidity associated with traumatic injuries. PMID:3662184

  15. Life seems pretty meaningful.

    PubMed

    Jeffery, Austin John; Shackelford, Todd K

    2015-09-01

    Comments on the original article "Life is pretty meaningful," by S. J. Heintzelman and L. A. King (see record 2014-03265-001). Heintzelman and King argue that, contrary to popular perception, our lives hold a great deal of meaning. The study of perceived meaning is an interesting and fruitful avenue. The current authors are concerned, however, that Heintzelman and King may have misrepresented and exploited the philosophical debate surrounding meaning to generate interest in their topic. Unless Heintzelman and King wish to argue that life truly is meaningful and that the perception of meaning is evidence enough, the current authors recommend that for the sake of clarity they make the explicit distinction between the widespread perception of meaning and its intrinsic existence. Unfortunately, once this distinction is made clear, these findings are less compelling to individuals who seek confirmation that intrinsic meaning exists. PMID:26348344

  16. Dangerous marine life.

    PubMed

    Harrison, L J

    1992-09-01

    All physicians must be educated in treating injuries incurred when a diver comes into contact with any dangerous marine life. Stinging invertebrates are the most commonly encountered dangerous marine animals. Venomous vertebrate marine animals are less common than stinging invertebrates and easier to recognize. However, they may be much more deadly. Sharks pose the greatest danger to divers. However, bites from other marine animals can be painful, become infected and require extensive medical treatment. PMID:1358999

  17. The right to life

    PubMed Central

    Boyd, Kenneth M

    1981-01-01

    For much of human history the idea of a right to life has not seemed self-evident. The credibility of the idea appears to depend on a particular kind of intuition concerning the nature of the world. In this paper, the kind of intuition involved is related to the idea of a covenant, illustrated by that of marriage. The paper concludes by suggesting that talk about responsibilities may be more fruitful than talk about rights. PMID:7277408

  18. Life in the Universe.

    NASA Astrophysics Data System (ADS)

    Weinberg, S.

    1994-10-01

    The author knows how physical forces emerging from the big bang 15 to 20 billion years ago have sculpted matter and energy into vast sheets of galaxies as well as into stars, planets and life itself. This understanding - modern science - constitutes one of humankind's greatest cultural achievements. Yet for all its sophistication, his knowledge encounters sharp limits. They arise from the paradox that he is trying to comprehend.

  19. Coating life prediction

    NASA Technical Reports Server (NTRS)

    Nesbitt, James A.; Gedwill, Michael A.

    1985-01-01

    The investigation combines both experimental studies and numerical modeling to predict coating life in an oxidizing environment. The experimental work provides both input to and verification of two numerical models. The coatings being examined are an aluminide coating on Udimet 700 (U-700), a low-pressure plasma spray (LPPS) Ni-18Co-17Cr-24Al-0.2Y overlay coating also on U- 700, and bulk deposits of the LPPS NiCoCrAlY coating.

  20. Life's expanding realm

    NASA Technical Reports Server (NTRS)

    Knoll, A.

    1994-01-01

    Geologic sediments from the Nullagine Range in Australia are used to illustrate the early existence of microbial communities in the oceans. These communities survived in oxygen-free environments. Some microbes, particularly cyanobacteria, developed the ability to synthesize energy from light, which led to the evolution of creatures with oxygen-dependent metabolism. Only recently has geologic evidence been discovered that supports the theory that animals developed only when there was enough oxygen in the atmosphere to support higher forms of life.

  1. End of life care.

    PubMed

    Gallacher, Rose

    2015-03-11

    End of life care is challenging, rewarding and a privileged experience, irrespective of where death occurs - in a hospital, care home, hospice, prison or at home. The CPD article was a reminder that death is a deeply personal and social experience, and one where individuals must be afforded dignity and respect. People who are dying should be referred to as individuals or persons, and not as patients. PMID:25758520

  2. Teacher Stress: Perceived and Objective Sources, and Quality of Life.

    ERIC Educational Resources Information Center

    Mykletun, Reidar J.

    1984-01-01

    A study of 912 Norwegian comprehensive school teachers, using a 74-item job stress rating scale to identify stressors in teachers' work and the General Health Questionnaire as an index of quality of life, identified nine stress factors, including work overload, pupils' misbehavior, change, organizational climate/staff relations. (MH)

  3. Child life services.

    PubMed

    2014-05-01

    Child life programs are an important component of pediatric hospital-based care to address the psychosocial concerns that accompany hospitalization and other health care experiences. Child life specialists focus on the optimal development and well-being of infants, children, adolescents, and young adults while promoting coping skills and minimizing the adverse effects of hospitalization, health care, and/or other potentially stressful experiences. Using therapeutic play, expressive modalities, and psychological preparation as primary tools, in collaboration with the entire health care team and family, child life interventions facilitate coping and adjustment at times and under circumstances that might otherwise prove overwhelming for the child. Play and developmentally appropriate communication are used to: (1) promote optimal development; (2) educate children and families about health conditions; (3) prepare children and families for medical events or procedures; (4) plan and rehearse useful coping and pain management strategies; (5) help children work through feelings about past or impending experiences; and (6) establish therapeutic relationships with patients, siblings, and parents to support family involvement in each child's care. PMID:24777212

  4. Obstetric life support.

    PubMed

    Puck, Andrea Lorraine; Oakeson, Ann Marie; Morales-Clark, Ana; Druzin, Maurice

    2012-01-01

    The death of a woman during pregnancy is devastating. Although the incidence of maternal cardiac arrest is increasing, it continues to be a comparatively rare event. Obstetric healthcare providers may go through their entire career without participating in a maternal cardiac resuscitation. Concern has been raised that when an arrest does occur in the obstetric unit, providers who are trained in life support skills at 2-year intervals are ill equipped to provide the best possible care. The quality of resuscitation skills provided during cardiopulmonary arrest of inpatients often may be poor, and knowledge of critical steps to be followed during resuscitation may not be retained after life support training. The Obstetric Life Support (ObLS) training program is a method of obstetric nursing and medical staff training that is relevant, comprehensive, and cost-effective. It takes into consideration both the care needs of the obstetric patient and the adult learning needs of providers. The ObLS program brings obstetric nurses, obstetricians, and anesthesiologists together in multidisciplinary team training that is crucial to developing efficient emergency response. PMID:22551860

  5. Quantiles Regression Approach to Identifying the Determinant of Breastfeeding Duration

    NASA Astrophysics Data System (ADS)

    Mahdiyah; Norsiah Mohamed, Wan; Ibrahim, Kamarulzaman

    In this study, quantiles regression approach is applied to the data of Malaysian Family Life Survey (MFLS), to identify factors which are significantly related to the different conditional quantiles of the breastfeeding duration. It is known that the classical linear regression methods are based on minimizing residual sum of squared, but quantiles regression use a mechanism which are based on the conditional median function and the full range of other conditional quantile functions. Overall, it is found that the period of breastfeeding is significantly related to place of living, religion and total number of children in the family.

  6. Astronomers Unveiling Life's Cosmic Origins

    NASA Astrophysics Data System (ADS)

    2009-02-01

    Processes that laid the foundation for life on Earth -- star and planet formation and the production of complex organic molecules in interstellar space -- are yielding their secrets to astronomers armed with powerful new research tools, and even better tools soon will be available. Astronomers described three important developments at a symposium on the "Cosmic Cradle of Life" at the annual meeting of the American Association for the Advancement of Science in Chicago, IL. Chemistry Cycle The Cosmic Chemistry Cycle CREDIT: Bill Saxton, NRAO/AUI/NSF Full Size Image Files Chemical Cycle Graphic (above image, JPEG, 129K) Graphic With Text Blocks (JPEG, 165K) High-Res TIFF (44.2M) High-Res TIFF With Text Blocks (44.2M) In one development, a team of astrochemists released a major new resource for seeking complex interstellar molecules that are the precursors to life. The chemical data released by Anthony Remijan of the National Radio Astronomy Observatory (NRAO) and his university colleagues is part of the Prebiotic Interstellar Molecule Survey, or PRIMOS, a project studying a star-forming region near the center of our Milky Way Galaxy. PRIMOS is an effort of the National Science Foundation's Center for Chemistry of the Universe, started at the University of Virginia (UVa) in October 2008, and led by UVa Professor Brooks H. Pate. The data, produced by the NSF's Robert C. Byrd Green Bank Telescope (GBT) in West Virginia, came from more than 45 individual observations totalling more than nine GigaBytes of data and over 1.4 million individual frequency channels. Scientists can search the GBT data for specific radio frequencies, called spectral lines -- telltale "fingerprints" -- naturally emitted by molecules in interstellar space. "We've identified more than 720 spectral lines in this collection, and about 240 of those are from unknown molecules," Remijan said. He added, "We're making available to all scientists the best collection of data below 50 GHz ever produced for

  7. Life Goals in Patients with Cancer: A Systematic Review of the Literature

    PubMed Central

    Hullmann, Stephanie E.; Robb, Sheri L.; Rand, Kevin L.

    2015-01-01

    Objective Purposes of this systematic review of life goal research in cancer patients were to: 1) identify life goal characteristics and processes being examined, 2) describe instruments used to assess life goal constructs, 3) identify theoretical models being used to guide research, and 4) summarize what is known about the impact of the cancer experience on life goal characteristics, processes, and psychological outcomes. Methods We conducted this systematic review using MEDLINE, PubMed, CINAHL, and PsycINFO databases. Inclusion criteria were: 1) published between 1993 and 2014, 2) English language, 3) cancer patient population, and 4) original research articles that assessed life goal characteristics and/or goal processes. One-hundred ninety-seven articles were screened and 27 included in the final review. Results Seven life goal characteristics and seven life goal processes were identified, and less than half of studies investigated associations between goal characteristics and processes. Conceptual definitions were not provided for about half of the identified life goal constructs. Studies used both validated and author-developed instruments to assess goal constructs. Twenty-four different theoretical models were identified, with self-regulation theory most frequently cited. Overall, the literature suggests that cancer impacts patients’ life goal characteristics and processes, and life goal disturbance is related to poorer psychological outcomes. Conclusions The impact of the cancer experience on life goals is an important and emerging area of research that would benefit from conceptual and theoretical clarity and measurement consistency. PMID:25990641

  8. Meaning in Life: One Link in the Chain from Religiousness to Well-Being

    ERIC Educational Resources Information Center

    Steger, Michael F.; Frazier, Patricia

    2005-01-01

    Meaning in life has been identified as a potential mediator of the link between religiousness and psychological health. The authors tested this hypothesis in 2 studies, using multiple methods and measures of religiousness and well-being. In the studies, meaning in life mediated the relation between religiousness and life satisfaction (Study 1A),…

  9. 41 CFR 102-33.120 - Are there special requirements for acquiring life-limited parts?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements for acquiring life-limited parts? 102-33.120 Section 102-33.120 Public Contracts and Property... Aircraft Parts § 102-33.120 Are there special requirements for acquiring life-limited parts? Yes, when you acquire new or used life-limited parts, you must— (a) Identify and inspect the parts, ensuring that...

  10. 41 CFR 102-33.120 - Are there special requirements for acquiring life-limited parts?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... requirements for acquiring life-limited parts? 102-33.120 Section 102-33.120 Public Contracts and Property... Aircraft Parts § 102-33.120 Are there special requirements for acquiring life-limited parts? Yes, when you acquire new or used life-limited parts, you must— (a) Identify and inspect the parts, ensuring that...

  11. The Dynamics of Life Skills Coaching. Life Skills Series.

    ERIC Educational Resources Information Center

    Curtiss, Paul R.; Warren, Phillip W.

    This book is to be used in a Life Skills Coach Training course. Life skills are defined as problem-solving behaviors appropriately and responsibly used in the management of personal affairs. They apply to the following areas of responsibility: self, family, leisure, community, and job. A course aimed at training people in the life skills implies…

  12. All about Animal Life Cycles. Animal Life for Children. [Videotape].

    ERIC Educational Resources Information Center

    2000

    While watching the development from tadpole to frog, caterpillar to butterfly, and pup to wolf, children learn about the life cycles of animals, the different stages of development, and the average life spans of a variety of creatures. This videotape correlates to the following National Science Education Standards for Life Science: characteristics…

  13. Cardiac Rehabilitation in Real Life

    PubMed Central

    Jankowski, Piotr; Pajak, Andrzej; Lysek, Radoslaw; Lukaszewska, Anna; Wolfshaut-Wolak, Renata; Bogacki, Piotr; Grodecki, Janusz; Mirek-Bryniarska, Ewa; Nessler, Jadwiga; Podolec, Piotr; Kawecka-Jaszcz, Kalina; Czarnecka, Danuta

    2015-01-01

    Abstract Participation in cardiac rehabilitation programs (CRPs) improves prognosis in patients with coronary artery disease (CAD). However, not much is known about the effectiveness of CRP in real life. The aim of this analysis was to identify factors related to the referral to CRP following hospitalization for CAD and estimate the effectiveness of the programs in real life. Medical records of 1061 consecutive patients aged ≤80 years, hospitalized due to an acute coronary syndrome or for a myocardial revascularization procedure in 5 hospitals serving the city and surrounding counties, were reviewed and 611 patients were interviewed 6–18 months posthospitalization. Of 611 patients participating in the interview, 212 (34.7%) were referred following the hospitalization to a center providing CRP. Age, hospitalization in a teaching hospital, and index diagnosis were independently related to being granted a referral. Among the referred patients, 86.3% participated in the CRP. Participation in CRP was related to the lower probability of having high total cholesterol (23% vs 32%, P < 0.05), fasting glucose (11% vs 18%, P = 0.05), HbA1c (8% vs 16%, P = 0.05), and body mass index (27% vs 37%, P < 0.05). Generally, the effect of the CRP was significant in participants with a higher education, but not in those with a low education level. Other factors were not significantly related to the effectiveness of CRP. This study shows that CRPs are effective, but underused in Poland. The participant's education level may influence the effectiveness of CRP. Therefore, in order to increase the impact of CRP, the content of such programs should vary depending on the education level of the participants. PMID:26266357

  14. Quality of life and the high-dependency unit.

    PubMed

    Brooks, N

    2000-02-01

    This study was designed to identify and measure the patients' perspective of the concept quality of life within the context of a high-dependency unit (HDU). Data were collected in two phases. In phase one, 55 patients were interviewed, which resulted in the concept clarification of quality of life as: physical, social, psychological and family/friends. In phase two, 51 patients undertook quality-of-life assessment using validated instruments the Quality of Life Index (Ferrans & Powers 1985) and the Global Quality of Life Scale (Hyland & Sodergren 1997). Post-HDU patients demonstrated improvements upon pre-admission scores in both instruments (the social domain in the quality of life index being the exception), although this only reached statistical significance P<0.05 in the overall index score and within the domains of health and family. When exploring variables of age and severity of illness (Apache 2 score, Knaus et al. 1980) it was the people who were older and physiologically compromised to an increased extent (P<0.05) who demonstrated higher levels of satisfaction with their resulting quality of life. This study has been successful in providing patients with an opportunity to participate more actively in service evaluation and has identified the need for future evaluation of HDUs to move beyond physiological measures, to incorporate the impact that illness leading to admission to an HDU has upon the patients' ability to function and their resulting quality of life. PMID:10790712

  15. Life, Death, and Second Chances

    MedlinePlus

    ... Home Current Issue Past Issues Special Section Life, Death, and Second Chances Past Issues / Fall 2007 Table ... New Asthma Guidelines: What You Should Know / Life, Death, and Second Chances / Asthma Research: The NIH-NJRC ...

  16. Last Days of Life (PDQ)

    MedlinePlus

    ... for more information. Symptoms During the Final Months, Weeks, and Days of Life Key Points Delirium Delirium ... may get worse during the final days or weeks of life. Shortness of breath or not being ...

  17. "Control Your Diabetes. For Life."

    MedlinePlus

    ... Javascript on. Feature: Diabetes "Control Your Diabetes. For Life." Past Issues / Fall 2009 Table of Contents For information about "Control Your Diabetes. For Life" campaign, visit www.YourDiabetesInfo.org or call toll- ...

  18. Space shuttle and life sciences

    NASA Technical Reports Server (NTRS)

    Mason, J. A.

    1977-01-01

    During the 1980's, some 200 Spacelab missions will be flown on space shuttle in earth-orbit. Within these 200 missions, it is planned that at least 20 will be dedicated to life sciences research, projects which are yet to be outlined by the life sciences community. Objectives of the Life Sciences Shuttle/Spacelab Payloads Program are presented. Also discussed are major space life sciences programs including space medicine and physiology, clinical medicine, life support technology, and a variety of space biology topics. The shuttle, spacelab, and other life sciences payload carriers are described. Concepts for carry-on experiment packages, mini-labs, shared and dedicated spacelabs, as well as common operational research equipment (CORE) are reviewed. Current NASA planning and development includes Spacelab Mission Simulations, an Announcement of Planning Opportunity for Life Sciences, and a forthcoming Announcement of Opportunity for Flight Experiments which will together assist in forging a Life Science Program in space.

  19. "Control Your Diabetes. For Life."

    MedlinePlus

    ... this page please turn Javascript on. Feature: Diabetes "Control Your Diabetes. For Life." Past Issues / Fall 2009 Table of Contents For information about "Control Your Diabetes. For Life" campaign, visit www.YourDiabetesInfo. ...

  20. The Life of Roger Langdon

    NASA Astrophysics Data System (ADS)

    Langdon, Roger; Langdon, Ellen

    2010-11-01

    Preface H. Clifton Lambert; 1. 'Why was I born?'; 2. Childhood's days; 3. Starting in life; 4. My secret departure; 5. Life in Jersey; 6. Return and marriage; 7. Scientific achievements; 8. Closing years; Appendices.

  1. Business and life in space

    NASA Technical Reports Server (NTRS)

    Allen, Joseph

    1990-01-01

    The life support systems in the machine called the Space Shuttle is discussed and later about life support systems in a little cocoon that is far smaller than the shuttle; the more common term is a space suit.

  2. Life, Death, and Second Chances

    MedlinePlus

    ... Bar Home Current Issue Past Issues Special Section Life, Death, and Second Chances Past Issues / Fall 2007 ... that she was beginning to fear for her life. Was there any hope at all? Dr. Richard ...

  3. Boiler-turbine life extension

    SciTech Connect

    Natzkov, S.; Nikolov, M.

    1995-12-01

    The design life of the main power equipment-boilers and turbines is about 105 working hours. The possibilities for life extension are after normatively regulated control tests. The diagnostics and methodology for Boilers and Turbines Elements Remaining Life Assessment using up to date computer programs, destructive and nondestructive control of metal of key elements of units equipment, metal creep and low cycle fatigue calculations. As well as data for most common damages and some technical decisions for elements life extension are presented.

  4. Preparing for life in space.

    PubMed

    Dasch, P

    1997-01-01

    The third team to inhabit the Advanced Life Support Test Chamber at the Johnson Space Center participated in an interview about life in the test chamber and program goals. Questions examine the air and water systems; human factors such as life in confinement, privacy, health, and training; and exercise. The test chamber is used to test life support systems for the International Space Station, lunar bases, and manned missions to Mars. PMID:11539459

  5. Life on Europa?

    NASA Astrophysics Data System (ADS)

    Shylaja, B. S.

    1997-06-01

    The notion of life has always fascinated curious minds. From prehistoric days, fancy voyages to other colonies and visits from non-earthly beings have been creatively imagined. Apart from science fictions, the last few centuries saw many observational investigations of "cities of Moon", "colonies of Mars" and so on. However, the sophisticated tools of the modern era quickly put a full stop to these developments revealing that the other planets are not hospitable, and infact hostile for a life form like ours to exist there. That explains why in the last few decades the efforts shifted to observing the satellites of large planets. The anxiety grew with the knowledge of their atmospheric structure, chemical composition and volcanic activity. Detection of water, albeit frozen, was a welcome surprise. The flyby of Voyager and Pioneer provided ample evidence for the presence of water, one of the most important ingredients for the germination of the seed of life. The detection of the fossil of a microorganism on a stone believed to have fallen from Mars, boosted the scientists zeal to pursue the research, although the date for life on Mars (more than 3 billion years ago) is not very convincing. Last year, many scientists, from different branches like astrophysics, geology, oceanography, biology and astrogeology discussed the possibilities of life elsewhere in the universe. The focal point was not Mars, but Europa, one of the Galilean satellites of Jupiter. Their studies based on Voyager images supported the possibility of liquid water beneath the frozen sheets of ice. However, heat is also an essential parameter. Europa, being at a distance five times the sun-earth separation can have only 1/25th the warmth of the earth. Then, where does it get the necessary warmth from? There are other important sources of heat in many of these satellites that lie concealed from our view. They are the volcanoes. If present, can these keep the water warm below the ice sheets? The unmanned

  6. A life course approach to reproductive health: theory and methods.

    PubMed

    Mishra, Gita D; Cooper, Rachel; Kuh, Diana

    2010-02-01

    Taking a life course approach to the study of reproductive health involves the investigation of factors across life and, also across generations, that influence the timing of menarche, fertility, pregnancy outcomes, gynaecological disorders, and age at menopause. It also recognises the important influence of reproductive health on chronic disease risk in later life. Published literature supports the use of an integrated life course approach to study reproductive health, which examines the whole life course, considers the continuity of reproductive health and the interrelationship between the different markers of this. This is in contrast to more traditional approaches that tend to focus only on contemporary risk factors and which consider each marker of reproductive health separately. For instance, we found evidence linking early life factors such as growth, socioeconomic conditions, and parental divorce with ages at menarche and menopause, although the nature of the relationship differs. We discuss the different theoretical models that are used within life course epidemiology and which postulate pathways linking exposures across the life course to health outcomes, using examples of relevance to the study of reproductive health. These highlight the importance of examining timing of exposures, such as during critical periods in early life, and the temporal order of exposures. How life course frameworks of reproductive health can be developed to help identify hypotheses to be tested is also demonstrated. This approach has implications for the development of effective health policy that moves beyond identifying not only the type of intervention but also the most appropriate time across life to intervene. PMID:20079587

  7. [Right to life?].

    PubMed

    1986-02-01

    The 1985 Conference of the Association for the Developmentally Disabled was held as a forum of discussion for the disabled, their families and specialists from various fields. Problems connected with fetal diagnosis, possibilities offered by it, and resulting ethical dilemmas are the main issue of focus. A parent speaker asked whether the suffering really is that of a mongoloid child or the environment. It is the societal values of achievement, effectiveness and success that negatively affect the developmentally disabled. The society that worships effectiveness has a negative attitude towards its less productive members. Magazines present calculations of each disabled person costing society 2-3 million markkas. The disabilities produce anxiety in doctors, who are trained to cure. Although the speaker did not deny the value of fetal diagnosis in promotion of life for those who desire the procedure, he was concerned about the trend towards increased societal "quality control" through it. Removal of the disabled might make life for others less worth living. Some discussion concentrated on the positive aspect of prevention through early diagnosis and treatment of maternal illnesses during pregnancy, vaccinating against microbes, giving special attention to risk births by providing safer settings and rendering effective treatment to newborn babies. Fetal diagnosis and resulting abortions have often been connected with prevention of disabilities. Each family needs to freely decide whether it is able to accept a disabled child in its own life situation, or whether it wants to choose an abortion. Another problem has been the short time span between diagnosis and legal time limits to perform an abortion. One recommendation has been to change the time limit to 24 weeks if the baby has a serious illness or bodily defect. It was recommended that prevention should not be based on benefit--expense calculations. The distorted attitudes need to be modified, and professionals need

  8. Coleridge's "theory of life".

    PubMed

    Smith, C U

    1999-01-01

    Coleridge has been seen by some not so much as a poet spoiled by philosophy, but as a philosopher who was also a poet. It could be argued that his major endeavor was an attempt to save the life sciences form the mechanistic interpretation which he saw as the outcome of Lockean "mechanico-corpuscularian" philosophy. This contribution describes that endeavour. It shows its connection to the social circumstances of the time. It discusses its relationship to the poetic sensibility of the "Lake poets" and to the German thought which Coleridge absorbed during and after his sojourn in Gottingen in 1798-99. It describes the nature of his "Theory of Life" as seen not only from the posthumous publication itself, but also from the numerous hints and struggles recorded in his voluminous notebooks, letters and lecture notes. It is concluded that, although never adequately assembled, it forms the only serious attempt to construct a profound alternative to the ultimately mechanistic biology of Charles Darwin and the psysiologists of the second half of the century. As such it strongly influenced the young Richard Owen and, as is well known, was eventually overwhelmed by the Darwin-Huxley synthesis of the 1860s. Nevertheless, insofar as Coleridge's concept of life ultimately derived from his ambition to find a way of healing the Cartesian divide, we may wonder whether the recent upsurge in consciousness studies may cause us to look again at his panentheistic ideas and, discarding the obsolete and fanciful metaphysics, recast them into a more acceptable form. PMID:11623814

  9. Classifying Life: The Astrobiological Challenge

    NASA Astrophysics Data System (ADS)

    Tobin, E.

    2013-09-01

    This paper will discuss efforts to define life. I will address how astrobiological research might allows us to conceptualise extreme conditions for life and thus allow us to give a much more nuanced definition of life. I also look at why this has ethical implications for society and humankin.

  10. Educators Get a "Second Life"

    ERIC Educational Resources Information Center

    Trotter, Andrew

    2008-01-01

    For educators who think real life does not offer enough opportunities to practice their profession, there is Second Life, an Internet-based virtual environment that counts thousands of educators among its enthusiasts. Second Life bears a passing resemblance to an online game, with users represented by digitally drawn characters, called avatars,…

  11. Space Biology: Patterns of Life

    ERIC Educational Resources Information Center

    Salisbury, Frank B.

    1971-01-01

    Present knowledge about Mars is compared with past beliefs about the planet. Biological experiments that indicate life may exist on Mars are interpreted. Life patterns or biological features that might be postulated for extraterrestrial life are presented at the molecular, cellular, organism, and ecosystem levels. (DS)

  12. Geography of European Life Satisfaction

    ERIC Educational Resources Information Center

    Okulicz-Kozaryn, Adam

    2011-01-01

    The vast majority of studies analyze life satisfaction at individual and/or country level. This study contributes with analysis of life satisfaction at the (sub-national) province level across multiple countries. The purpose of this study is to call attention to spatial aspects of life satisfaction. Literature does not discuss the fact that life…

  13. The Early Years: "Life" Science

    ERIC Educational Resources Information Center

    Ashbrook, Peggy

    2013-01-01

    Talking about death as part of a life cycle is often ignored or spoken about in hushed tones in early childhood. Books with "life cycle" in the title often do not include the death of the living organism in the information about the cycle. The concept of a complete life cycle does not appear in "A Framework for K-12 Science…

  14. End of Life: An Overview

    ERIC Educational Resources Information Center

    Toner, Mary Ann; Shadden, Barbara B.

    2012-01-01

    Speech-language pathologists (SLPs) provide services to patients confronting the end of life (EOL) in a variety of settings. Instead of targeting improvement of health or sustaining life, EOL services focus primarily on quality of life. Although SLPs may not consider themselves core members of the health care team providing EOL services, the…

  15. 10 Ways to Identify Hearing Loss

    MedlinePlus

    ... Current Issue Past Issues 10 Ways to Identify Hearing Loss Past Issues / Spring 2007 Table of Contents For ... exposure and other causes. 10 Ways to Identify Hearing Loss Take the following quiz to help determine if ...

  16. NIH Researchers Identify OCD Risk Gene

    MedlinePlus

    ... News From NIH NIH Researchers Identify OCD Risk Gene Past Issues / Summer 2006 Table of Contents For ... and Alcoholism (NIAAA) have identified a previously unknown gene variant that doubles an individual's risk for obsessive- ...

  17. Astrophysics of Life

    NASA Astrophysics Data System (ADS)

    Livio, Mario; Reid, I. Neill; Sparks, William B.

    2011-03-01

    1. A voyage from dark clouds to the early Earth P. Ehrenfreund, S. B. Charnley and O. Botta; 2. Galactic environment of the Sun and stars: interstellar and interplanetary material P. C. Frisch, H. R. Muller, G. P. Zank and C. Lopate; 3. Transits R. L. Gilliland; 4. Planet migration E. W. Thommes and J. J. Lissauer; 5. Organic synthesis in space S. A. Sandford; 6. The Vegetation Red Edge Spectroscopic Feature as a surface biomarker S. Seager and E. B. Ford; 7. Search for extra-solar planets through gravitational microlensing K. C. Sahu; 8. The galactic habitable zone G. Gonzalez; 9. Cosmology and life M. Livio.

  18. Astrophysics of Life

    NASA Astrophysics Data System (ADS)

    Livio, Mario; Reid, I. Neill; Sparks, William B.

    2005-01-01

    1. A voyage from dark clouds to the early Earth P. Ehrenfreund, S. B. Charnley and O. Botta; 2. Galactic environment of the Sun and stars: interstellar and interplanetary material P. C. Frisch, H. R. Muller, G. P. Zank and C. Lopate; 3. Transits R. L. Gilliland; 4. Planet migration E. W. Thommes and J. J. Lissauer; 5. Organic synthesis in space S. A. Sandford; 6. The Vegetation Red Edge Spectroscopic Feature as a surface biomarker S. Seager and E. B. Ford; 7. Search for extra-solar planets through gravitational microlensing K. C. Sahu; 8. The galactic habitable zone G. Gonzalez; 9. Cosmology and life M. Livio.

  19. Mean life of klystrons

    SciTech Connect

    Sands, M.

    1985-10-30

    It would be useful to have the best possible estimate of this mean life-time of our new klystrons based on the most recent, available operating experience. A simple formula is given for this best estimate, based on the maximum likelihood method. This method also provides an indication of the reliability of the estimated lifetime. The results given here apply uniquely to a uniform klystron population for which we can assume that deaths occur randomly, and independently of the previous history (operating time) of any one klystron.

  20. Geothermal Life Cycle Calculator

    DOE Data Explorer

    Sullivan, John

    2014-03-11

    This calculator is a handy tool for interested parties to estimate two key life cycle metrics, fossil energy consumption (Etot) and greenhouse gas emission (ghgtot) ratios, for geothermal electric power production. It is based solely on data developed by Argonne National Laboratory for DOE’s Geothermal Technologies office. The calculator permits the user to explore the impact of a range of key geothermal power production parameters, including plant capacity, lifetime, capacity factor, geothermal technology, well numbers and depths, field exploration, and others on the two metrics just mentioned. Estimates of variations in the results are also available to the user.

  1. Exploring for Martian Life

    NASA Technical Reports Server (NTRS)

    Farmer, Jack D.; Chang, Sherwood (Technical Monitor)

    1997-01-01

    During the next decade, robotic field science will play an essential role in advancing our understanding of Martian history. Specifically, capable rovers are needed to survey a broad range of Martian rock types for in situ chemistry and mineralogy as a basis for interpreting globally-distributed data obtained from orbit. The relationship between orbital and landed science will be fundamental in selecting a landing site for future missions aimed at probing the ancient rock record for evidence of: (1) past life or prebiotic chemistry; (2) the climate and volatile history of Mars; and (3) candidate materials for in situ resource utilization.

  2. The chemical life(1).

    PubMed

    Hodges, Nathan

    2015-01-01

    You write this narrative autoethnography to open up a conversation about our chemical lives. You go through your day with chemical mindfulness, questioning taken-for-granted ideas about natural and artificial, healthy and unhealthy, dependency and addiction, trying to understand the chemical messages we consume through the experiences of everyday life. You reflect on how messages about chemicals influence and structure our lives and why some chemicals are celebrated and some are condemned. Using a second-person narrative voice, you show how the personal is relational and the chemical is cultural. You write because you seek a connection, a chemical bond. PMID:24905820

  3. What is Life?

    NASA Astrophysics Data System (ADS)

    Schrodinger, Erwin; Penrose, Foreword by Roger

    2012-03-01

    Preface; 1. The classical physicist's approach to the subject; 2. The hereditary mechanism; 3. Mutations; 4. The quantum-mechanical evidence; 5. Delbruck's model discussed and tested; 6. Order, disorder and entropy; 7. Is life based on the laws of physics?; Epilogue: on determinism and free will; Mind and Matter: 1. The physical basis of consciousness; 2. The future of understanding; 3. The principle of objectivation; 4. The arithmetical paradox: the oneness of mind; 5. Science and religion; 6. The mystery of the sensual qualities; Autobiographical sketches (translated from the German by Schrödinger's granddaughter Verena).

  4. This thing called life.

    PubMed

    Atherley, Anique E N; Taylor, Charles G

    2015-08-01

    Academic pursuits are inseparable from the medium within which they take place - life. The lives of medical trainees can present many challenges that are independent of academic demands. Poor psychological health has been found to develop in medical trainees. Can medical educators minimize this decline in well-being? Positive education - learning skills for traditional academia and to foster happiness - has been shown to improve students' well-being. This piece considers the application of 'positive education' to medical training. By using this approach, we may optimize the lives of our trainees, potentially enhance learning and improve their academic and personal outcomes. PMID:26179675

  5. [Alcohol and working life].

    PubMed

    Kaarne, Tiina; Aalto, Mauri

    2009-01-01

    Alcohol-related harm constitutes a significant factor decreasing work productivity. Of heavy alcohol users, most participate in working life. According to labour contract law, a person attending the workplace inebriated can be fired. If the employer applies a deferral to treatment practice, the drug- or alcohol-addicted person can be provided with the choice of therapy and rehabilitation instead of terminating the employment. According to the recent recommendation by the trade unions, organizations should have a program for preventing substance abuse. The employer should take care of the worker's intoxicant education and train the foremen to intervene in the situations on time. PMID:19492706

  6. Effect of Individual Component Life Distribution on Engine Life Prediction

    NASA Technical Reports Server (NTRS)

    Zaretsky, Erwin V.; Hendricks, Robert C.; Soditus, Sherry M.

    2003-01-01

    The effect of individual engine component life distributions on engine life prediction was determined. A Weibull-based life and reliability analysis of the NASA Energy Efficient Engine was conducted. The engine s life at a 95 and 99.9 percent probability of survival was determined based upon the engine manufacturer s original life calculations and assumed values of each of the component s cumulative life distributions as represented by a Weibull slope. The lives of the high-pressure turbine (HPT) disks and blades were also evaluated individually and as a system in a similar manner. Knowing the statistical cumulative distribution of each engine component with reasonable engineering certainty is a condition precedent to predicting the life and reliability of an entire engine. The life of a system at a given reliability will be less than the lowest-lived component in the system at the same reliability (probability of survival). Where Weibull slopes of all the engine components are equal, the Weibull slope had a minimal effect on engine L(sub 0.1) life prediction. However, at a probability of survival of 95 percent (L(sub 5) life), life decreased with increasing Weibull slope.

  7. Life history diversity in Klamath River steelhead

    USGS Publications Warehouse

    Hodge, Brian W.; Wilzbach, Peggy; Duffy, Walter G. G.; Quinones, Rebecca M.; Hobbs, James A.

    2016-01-01

    Oncorhynchus mykiss exhibits a vast array of life histories, which increases its likelihood of persistence by spreading risk of extirpation among different pathways. The Klamath River basin (California–Oregon) provides a particularly interesting backdrop for the study of life history diversity in O. mykiss, in part because the river is slated for a historic and potentially influential dam removal and habitat recolonization project. We used scale and otolith strontium isotope (87Sr/86Sr) analyses to characterize life history diversity in wildO. mykiss from the lower Klamath River basin. We also determined maternal origin (anadromous or nonanadromous) and migratory history (anadromous or nonanadromous) of O. mykiss and compared length and fecundity at age between anadromous (steelhead) and nonanadromous (Rainbow Trout) phenotypes of O. mykiss. We identified a total of 38 life history categories at maturity, which differed in duration of freshwater and ocean rearing, age at maturation, and incidence of repeat spawning. Approximately 10% of adult fish sampled were nonanadromous. Rainbow Trout generally grew faster in freshwater than juvenile steelhead; however, ocean growth afforded adult steelhead greater length and fecundity than adult Rainbow Trout. Although 75% of individuals followed the migratory path of their mother, steelhead produced nonanadromous progeny and Rainbow Trout produced anadromous progeny. Overall, we observed a highly diverse array of life histories among Klamath River O. mykiss. While this diversity should increase population resilience, recent declines in the abundance of Klamath River steelhead suggest that life history diversity alone is not sufficient to stabilize a population. Our finding that steelhead and Rainbow Trout give rise to progeny of the alternate form (1) suggests that dam removal might lead to a facultatively anadromous O. mykiss population in the upper basin and (2) raises the question of whether both forms of

  8. 29 CFR 4010.7 - Identifying information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Identifying information. 4010.7 Section 4010.7 Labor... DISCLOSURE REQUIREMENTS ANNUAL FINANCIAL AND ACTUARIAL INFORMATION REPORTING § 4010.7 Identifying information..., http://www.pbgc.gov, the following identifying information with respect to each member of the...

  9. Method of identifying plant pathogen tolerance

    DOEpatents

    Ecker, Joseph R.; Staskawicz, Brian J.; Bent, Andrew F.; Innes, Roger W.

    1997-10-07

    A process for identifying a plant having disease tolerance comprising administering to a plant an inhibitory amount of ethylene and screening for ethylene insensitivity, thereby identifying a disease tolerant plant, is described. Plants identified by the foregoing process are also described.

  10. Ability of Slovakian Pupils to Identify Birds

    ERIC Educational Resources Information Center

    Prokop, Pavol; Rodak, Rastislav

    2009-01-01

    A pupil's ability to identify common organisms is necessary for acquiring further knowledge of biology. We investigated how pupils were able to identify 25 bird species following their song, growth habits, or both features presented simultaneously. Just about 19% of birds were successfully identified by song, about 39% by growth habit, and 45% of…

  11. Method of identifying plant pathogen tolerance

    DOEpatents

    Ecker, J.R.; Staskawicz, B.J.; Bent, A.F.; Innes, R.W.

    1997-10-07

    A process for identifying a plant having disease tolerance comprising administering to a plant an inhibitory amount of ethylene and screening for ethylene insensitivity, thereby identifying a disease tolerant plant, is described. Plants identified by the foregoing process are also described. 7 figs.

  12. LATENT LIFE OF ARTERIES.

    PubMed

    Carrel, A

    1910-07-23

    When a segment of artery, killed by heat, formalin or glycerin is transplanted, it undergoes a rapid degeneration. Its muscle fibers disappear while the tissue of the host reacts by building a new wall of connective tissue. When the transplanted vessel has been preserved in a condition of latent life, no degeneration of the wall occurs, or the wall undergoes only partial degeneration. The muscle fibers can keep their normal appearance, even for a long time after the operation. It is, therefore, demonstrated that arteries can be preserved outside of the body in a condition of unmanifested actual life. The best method of preservation consists of placing the vessels, immersed in vaselin, in an ice box, the temperature of which is slightly above the freezing point. From a surgical standpoint, the transplantation of preserved vessels can be used with some safety. When the arteries were kept in defibrinated blood or vaselin and in cold storage, the proportion of positive results was 75 and 80 per cent., and this can probably be increased. PMID:19867337

  13. Lifing of Engine Components

    NASA Technical Reports Server (NTRS)

    2005-01-01

    The successful development of advanced aerospace engines depends greatly on the capabilities of high performance materials and structures. Advanced materials, such as nickel based single crystal alloys, metal foam, advanced copper alloys, and ceramics matrix composites, have been engineered to provide higher engine temperature and stress capabilities. Thermal barrier coatings have been developed to improve component durability and fuel efficiency, by reducing the substrate hot wall metal temperature and protecting against oxidation and blanching. However, these coatings are prone to oxidation and delamination failures. In order to implement the use of these materials in advanced engines, it is necessary to understand and model the evolution of damage of the metal substrate as well as the coating under actual engine conditions. The models and the understanding of material behavior are utilized in the development of a life prediction methodology for hot section components. The research activities were focused on determining the stress and strain fields in an engine environment under combined thermo-mechanical loads to develop life prediction methodologies consistent with the observed damage formation of the coating and the substrates.

  14. Creativity in later life.

    PubMed

    Price, K A; Tinker, A M

    2014-08-01

    The ageing population presents significant challenges for the provision of social and health services. Strategies are needed to enable older people to cope within a society ill prepared for the impacts of these demographic changes. The ability to be creative may be one such strategy. This review outlines the relevant literature and examines current public health policy related to creativity in old age with the aim of highlighting some important issues. As well as looking at the benefits and negative aspects of creative activity in later life they are considered in the context of the theory of "successful ageing". Creative activity plays an important role in the lives of older people promoting social interaction, providing cognitive stimulation and giving a sense of self-worth. Furthermore, it is shown to be useful as a tool in the multi-disciplinary treatment of health problems common in later life such as depression and dementia. There are a number of initiatives to encourage older people to participate in creative activities such as arts-based projects which may range from visual arts to dance to music to intergenerational initiatives. However, participation shows geographical variation and often the responsibility of provision falls to voluntary organisations. Overall, the literature presented suggests that creative activity could be a useful tool for individuals and society. However, further research is needed to establish the key factors which contribute to patterns of improved health and well-being, as well as to explore ways to improve access to services. PMID:24974278

  15. Life from the core

    NASA Astrophysics Data System (ADS)

    Doglioni, Carlo; Coleman, Max; Pignatti, Johannes; Glassmeier, Karl-Heinz

    2010-05-01

    Life on Earth is the result of the chaotic combination of several independent chemical and physical parameters. One of them is the shield from ionizing radiation exerted by the atmosphere and the Earth's magnetic field. We hypothesise that the first few billion years of the Earth's history, dominated by bacteria, were characterized by stronger ionizing radiation. Bacteria can survive under such conditions better than any other organism. During the Archean and early Proterozoic the shield could have been weaker, allowing the development of only a limited number of species, more resistant to the external radiation. The Cambrian explosion of life could have been enhanced by the gradual growth of the solid inner core, which was not existent possibly before 1 Ga. The cooling of the Earth generated the solidification of the iron alloy in the center of the planet. As an hypothesis, before the crystallization of the core, the turbulence in the liquid core could have resulted in a lower or different magnetic field from the one we know today, being absent the relative rotation between inner and external core.

  16. Zebra mussel life history

    SciTech Connect

    Ackerman, J.D.

    1995-06-01

    The success of introduced zebra mussels (Dreissena polymorpha (Pallas) and Dreissena bugensis Andrusova) can be related in large parttot a life history that is unlike that of the indigenous freshwater fauna and yet is conserved with marine bivalves. Following external fertilization and embryological development, there is a brief trochophore stage. With the development of a velum and the secretion of a D-shaped larval shell, the larva becomes a D-shaped veliger, which is the first recognizable planktonic larva. Later, the secretion of a second larval shell leads to the last obligate free-swimming veliger stage known as the veliconcha. The last larval stage known as the pediveliger, however, can both swim using its velum or crawl using its fully-functional foot. Pediveligers actively select substrates on which they {open_quotes}settle{close_quotes} by secreting byssal threads and undergo metamorphosis to become plantigrade mussels. The secretion of the adult shell and concomitant changes in growth axis leads to the heteromyariant or mussel-like shape, which is convergent with marine mussels. Like a number of other bivalves, zebra mussels produce byssal threads as adults, but these attachments may be broken enabling their translocation to new areas. The recognition and examination of these life history traits will lead to a better understanding of zebra mussel biology.

  17. Self-identified health concerns of two homeless groups.

    PubMed

    Kinzel, D

    1991-04-01

    A number of conclusions can be drawn from the themes derived from the interview data. First, even though the most basic physical needs, such as food, clothing, and shelter were being met, a recurring theme from the responses of the homeless was the need for interaction with a caring person. The feeling that no one cares, a lack of self-worth, and a sense of limited control over their lives may lead to depression, hopelessness, and finally illness. The extent and effectiveness of health-seeking behaviors among this group are limited because of decreased trust, decreased motivation for self-care, and isolation from social and health care systems. Second, if health needs are to be met, services must be provided in sites where they can be accessed by the homeless. For transients, health care services may be provided most effectively through the shelters. For the SRO residents, these services could be provided through a combination of clinics in hotel lobbies and visits to rooms. Third, developing trust with the homeless includes meeting their self-perceived basic needs. What may seem like nonnursing activities, such as fixing a meal, may be important in establishing rapport with SRO residents. If a nurse assists a homeless person to meet survival needs, that person may be more willing to deal with health issues. Fourth, the population is highly heterogeneous. Each subgroup has its own identity. Most SRO residents do not want to be identified with street people, even through a portion of them move between street life and SRO life. Health care professionals need to recognize these differences, accept the life-style of each subgroup, and respect each homeless person as a unique individual. Finally, caring is the primary element necessary in providing nursing services to the homeless. Awareness and understanding of the homeless way of life will increase nurses' effectiveness in working with this ever growing population. PMID:2048311

  18. [Life expectancy and median life in life tables: the historical emergence of these measures].

    PubMed

    Lombardo, E

    1985-01-01

    The author describes the development of two measures used in life tables, life expectancy and median length of life. These measures were developed during the course of correspondence between the Dutch brothers Christiaan and Lodewijk Huygens in 1669. (summary in ENG, FRE) PMID:12314148

  19. Archaea: The First Domain of Diversified Life

    PubMed Central

    Caetano-Anollés, Gustavo; Nasir, Arshan; Zhou, Kaiyue; Caetano-Anollés, Derek; Mittenthal, Jay E.; Sun, Feng-Jie; Kim, Kyung Mo

    2014-01-01

    The study of the origin of diversified life has been plagued by technical and conceptual difficulties, controversy, and apriorism. It is now popularly accepted that the universal tree of life is rooted in the akaryotes and that Archaea and Eukarya are sister groups to each other. However, evolutionary studies have overwhelmingly focused on nucleic acid and protein sequences, which partially fulfill only two of the three main steps of phylogenetic analysis, formulation of realistic evolutionary models, and optimization of tree reconstruction. In the absence of character polarization, that is, the ability to identify ancestral and derived character states, any statement about the rooting of the tree of life should be considered suspect. Here we show that macromolecular structure and a new phylogenetic framework of analysis that focuses on the parts of biological systems instead of the whole provide both deep and reliable phylogenetic signal and enable us to put forth hypotheses of origin. We review over a decade of phylogenomic studies, which mine information in a genomic census of millions of encoded proteins and RNAs. We show how the use of process models of molecular accumulation that comply with Weston's generality criterion supports a consistent phylogenomic scenario in which the origin of diversified life can be traced back to the early history of Archaea. PMID:24987307

  20. 1991 NASA Life Support Systems Analysis workshop

    NASA Technical Reports Server (NTRS)

    Evanich, Peggy L.; Crabb, Thomas M.; Gartrell, Charles F.

    1992-01-01

    The 1991 Life Support Systems Analysis Workshop was sponsored by NASA Headquarters' Office of Aeronautics and Space Technology (OAST) to foster communication among NASA, industrial, and academic specialists, and to integrate their inputs and disseminate information to them. The overall objective of systems analysis within the Life Support Technology Program of OAST is to identify, guide the development of, and verify designs which will increase the performance of the life support systems on component, subsystem, and system levels for future human space missions. The specific goals of this workshop were to report on the status of systems analysis capabilities, to integrate the chemical processing industry technologies, and to integrate recommendations for future technology developments related to systems analysis for life support systems. The workshop included technical presentations, discussions, and interactive planning, with time allocated for discussion of both technology status and time-phased technology development recommendations. Key personnel from NASA, industry, and academia delivered inputs and presentations on the status and priorities of current and future systems analysis methods and requirements.

  1. Progress in Life Marker Chip Technology for Detection of Life on Mars

    NASA Astrophysics Data System (ADS)

    Sims, M. R.; Cullen, D. C.; Laan, E.; Borst, G.; Prak, A.; Richter, L.; Gaubert, F.; Steele, A.; Parnell, J.; Sephton, M.

    2007-12-01

    Detection of Life on Mars will rely on detection of biomarkers, physical or chemical structures that can be associated with Life. As a possible payload for the ESA ExoMars rover mission planned in 2013 and other future missions a Life Marker Chip instrument is being developed. This instrument uses immuno-assay techniques to detect the relevant biomarkers. This paper describes the typical targets it will search for, its operating principle and the status of development. 63 biomarker targets have been identified and assays have been developed for a limited subset. Assay development includes use of recombinant DNA techniques to generate the molecular receptors (antibodies). This type of instrument has applications in terrestrial research e.g. sub-glacial lakes as well as planetary exploration. Breadboard demonstrators have been built of the assay system and key components of the micro-fluidics. Results from these breadboards will be presented, along with plans for future development.

  2. A Life Worth Giving? The Threshold for Permissible Withdrawal of Life Support From Disabled Newborn Infants

    PubMed Central

    Wilkinson, Dominic James

    2011-01-01

    When is it permissible to allow a newborn infant to die on the basis of their future quality of life? The prevailing official view is that treatment may be withdrawn only if the burdens in an infant's future life outweigh the benefits. In this paper I outline and defend an alternative view. On the Threshold View, treatment may be withdrawn from infants if their future well-being is below a threshold that is close to, but above the zero-point of well-being. I present four arguments in favor of the Threshold View, and identify and respond to several counterarguments. I conclude that it is justifiable in some circumstances for parents and doctors to decide to allow an infant to die even though the infant's life would be worth living. The Threshold View provides a justification for treatment decisions that is more consistent, more robust, and potentially more practical than the standard view. PMID:21337273

  3. Life course impairment and quality of life over time.

    PubMed

    Sampogna, Francesca

    2013-01-01

    The concepts of cumulative life course impairment (CLCI) and health-related quality of life (QoL) are analyzed, in order to find shared and divergent aspects. The concept of QoL includes the patients' perception of their health and their personal experiences concerning the psychosocial impact of the disease on their life. CLCI aims to investigate the impact of a chronic disease on the milestones of life, such as education, work, relationships, children, social life, (briefly - on the whole trajectory of life) and on how the disease influenced the possibility of patients of living their life up to its full potential. QoL is a cross-sectional measure, while CLCI takes into account the lifetime. However, it is clear that the possibility of reaching one's full life potential and QoL at a certain time are correlated. There are few studies in dermatology in this field; however, both in the case of atopic dermatitis and of vitiligo it has been shown that patients with a severe condition in childhood endured severe psychosocial and physical consequences in adulthood and experienced a profound negative impact of the disease on their current quality of life. It is thus important to take into account both CLCI and QoL when evaluating the impact of a chronic condition on a patient's life. PMID:23796808

  4. Live your life out loud.

    PubMed

    Gatrell, Nanette; Rothblum, Esther

    2014-01-01

    Susan Love, MD, MBA, has dedicated her professional life to the eradication of breast cancer. Author of the bestselling Dr. Susan Love's Breast Book, Dr. Susan Love's Menopause and Hormone Book, and Live a Little, Susan is Chief Visionary Officer of the Dr. Susan Love Research Foundation where she oversees an active research program centered on breast cancer cause and prevention. Susan co-founded the National Breast Cancer Coalition in the early 1990s, and she served on President Clinton's National Cancer Advisory Board from 1998-2004. Her recent projects include recruiting 377,000 women for the Love Army of Women, an Internet program that partners women and scientists to accelerate breast cancer research; and the online Health of Women Study designed to identify the cause of breast cancer. A recipient of six honorary doctorate degrees, Susan is Clinical Professor of Surgery at the David Geffen School of Medicine at the University of California, Los Angeles. In June of 2012, Susan was diagnosed with acute myelogenous leukemia and was treated with an allogenic stem cell transplant. PMID:24400625

  5. Risk assessment and life prediction of complex engineering systems

    SciTech Connect

    Garcia, M.D.; Varma, R.; Heger, A.S.

    1996-03-01

    Many complex engineering systems will exceed their design life expectancy within the next 10 to 15 years. It is also expected that these systems must be maintained and operated beyond their design life. This paper presents a integrated approach for managing the risks associated with aging effects and predicting the residually expectancy these systems, The approach unifies risk assessment, enhanced surveillance and testing, and robust computational models to assess the risk, predict age, and develop a life-extension management procedure. It also relies on the state of the art in life-extension and risk assessment methods from the nuclear power industry. Borrowing from the developments in decision analysis, this approach should systematically identify the options available for managing the existing aging systems beyond their intended design life.

  6. Application of Computer Tomography for Life Detection

    NASA Technical Reports Server (NTRS)

    Tsapin, A.; Nealson, K.

    2001-01-01

    Perhaps one of the most fundamentally difficult challenges facing those who would search for life is that of scale determination. Spatial scales of life on Earth range over more than 15 orders of magnitude in mass and volume, and more than 8 orders of magnitude in 2 dimensional space. If the distribution of life is sparse in comparison to the background on which it is found, then the choice of the right scale is critical to finding that life. But how does one identify the proper scale? To put this in other words, how does one recognize the "haystacks" in which the needles (biosignatures and evidence of life) might be most profitably searched for? The problem is further exacerbated when conditions get extreme because much of the life moves from the clement surface environment into the pores and more clement environments inside of rocks, minerals and soils. Once encased in their lithic homes, these microbes become nearly impossible to study by standard techniques because of the opacity of the rocks. It is this problem that we propose to address in the work proposed here. Computer Tomography (CT) has been a very valuable tool in medicine, where the best resolution available has typically been of the order of about 0.5 mm. However, to adapt the approach for life detection of microbial endoliths, the resolution needs to be moved to the micrometer and even submicrometer levels. Thus for the studies proposed here, we begin with a commercially available instrument that can yield resolution of approximately 10 micrometers. The rational for this is twofold: first, this is the "state of the art" in laboratory instruments; and second, that while the usual size of a microbial cell is about 1 micron, microorganisms tend to live in communities that usually exceed the 10 micrometer size range. The resolution also depends on the sample size itself, so having a small lab instrument into which small samples can be placed will be beneficial to the resolution. We have now used several

  7. Science for Real Life

    ERIC Educational Resources Information Center

    Hammerman, Elizabeth

    2008-01-01

    State and national standards identify what students should know and be able to do, including what it means to "do" science, the historical significance of science achievement and its ethical underpinnings, and science from the human perspective. Middle level science programs that address the full range of science standards and connect learning to…

  8. Life shocks and homelessness.

    PubMed

    Curtis, Marah A; Corman, Hope; Noonan, Kelly; Reichman, Nancy E

    2013-12-01

    We exploited an exogenous health shock-namely, the birth of a child with a severe health condition-to investigate the effect of a life shock on homelessness in large cities in the United States as well as the interactive effects of the shock with housing market characteristics. We considered a traditional measure of homelessness, two measures of housing instability thought to be precursors to homelessness, and a combined measure that approximates the broadened conceptualization of homelessness under the 2009 Homeless Emergency Assistance and Rapid Transition to Housing Act (2010). We found that the shock substantially increases the likelihood of family homelessness, particularly in cities with high housing costs. The findings are consistent with the economic theory of homelessness, which posits that homelessness results from a conjunction of adverse circumstances in which housing markets and individual characteristics collide. PMID:23868747

  9. Aircraft wheel life assessment

    NASA Astrophysics Data System (ADS)

    Spencer, B. F., Jr.; Kirkner, D. J.; Schudt, E. E.; Kandarpa, S.

    1993-07-01

    The important part of wheel life assessment problems is the accurate determination of the tire/wheel interface pressure distribution under various loading conditions. A combined analytical/experimental methodology for obtaining this pressure distribution was developed. The principal analytical tool in this methodology is the finite element program ANTWILL (Analysis of Tire Wheel Interface Loads) which recovers the pressure distribution given a number of experimental strain measurements on the wheel. The major activity consisted of a study of the F-16 Block 30 and the Block 40 main landing gear wheels to determine the optimal number and location of the strain gages for subsequent experiments. Experiments to be conducted will record strains at the specified locations and this data will be used to determine tire/wheel interface pressures.

  10. Fossil life on Mars

    NASA Technical Reports Server (NTRS)

    Walter, M. R.

    1989-01-01

    Three major problems beset paleontologists searching for morphological evidence of life on early Earth: selecting a prospective site; finding biogenic structures; and distinguishing biogenic from abiogenic structures. The same problems arise on Mars. Terrestrial experience suggests that, with the techniques that can be employed remotely, ancient springs, including hot springs, are more prospective than lake deposits. If, on the other hand, the search is for chemical evidence, the strategy can be very different, and lake deposits are attractive targets. Lakes and springs frequenly occur in close proximity, and therefore a strategy that combines the two would seem to maximize the chance of success. The strategy for a search for stromatolite on Mars is discussed.

  11. Negative Entropy of Life

    NASA Astrophysics Data System (ADS)

    Goradia, Shantilal

    2015-10-01

    We modify Newtonian gravity to probabilistic quantum mechanical gravity to derive strong coupling. If this approach is valid, we should be able to extend it to the physical body (life) as follows. Using Boltzmann equation, we get the entropy of the universe (137) as if its reciprocal, the fine structure constant (ALPHA), is the hidden candidate representing the negative entropy of the universe which is indicative of the binary information as its basis (http://www.arXiv.org/pdf/physics0210040v5). Since ALPHA relates to cosmology, it must relate to molecular biology too, with the binary system as the fundamental source of information for the nucleotides of the DNA as implicit in the book by the author: ``Quantum Consciousness - The Road to Reality.'' We debate claims of anthropic principle based on the negligible variation of ALPHA and throw light on thermodynamics. We question constancy of G in multiple ways.

  12. Game of Life Music

    NASA Astrophysics Data System (ADS)

    Miranda, Eduardo R.; Kirke, Alexis

    At the time when the first author was post-graduate student, in the evenings he used to entertain himself with the equipment in the electronic music studio at the University of York until dawn. It must have been around three o'clock in the morning of a rather cold winter night in the late 1980s, when he connected his Atari 1040ST computer to a synthesizer to test the first prototype of a system, which he was developing for his thesis. The system, named CAMUS (short for Cellular Automata Music), implemented a method that he invented to render music from the behaviour of the Game of Life (GoL) cellular automata (CA).

  13. Origin of life

    NASA Technical Reports Server (NTRS)

    Chang, S.

    1985-01-01

    The pathways of organic chemical synthesis, the chemical evolution on the early Earth leading to life was constrained by the development of the planet by accretion and core formation. The accretion and differentiation into the core-mantle-crust-atmosphere system strongly influenced the temperature and composition of the atmosphere, surface, and interior; but large gaps persist in our understanding of these processes. The time-span over which Earth acquired its volatiles, the composition of these volatiles, and the conditions under which outgassing of volatiles occurred to form the atmosphere, are unknown. Uncertainties in existing models for Earth accretion and early planetary development allows a wide range of possible prebiotic atmospheric compositions at the time and temperature when liquid water appeared and thermally-labile organic compounds could survive. These compositions range from strongly reducing atmospheres to mildly reducing ones.

  14. Life Shocks and Homelessness

    PubMed Central

    Corman, Hope; Noonan, Kelly; Reichman, Nancy E.

    2014-01-01

    We exploited an exogenous health shock—namely, the birth of a child with a severe health condition—to investigate the effect of a life shock on homelessness in large cities in the United States as well as the interactive effects of the shock with housing market characteristics. We considered a traditional measure of homelessness, two measures of housing instability thought to be precursors to homelessness, and a combined measure that approximates the broadened conceptualization of homelessness under the 2009 Homeless Emergency Assistance and Rapid Transition to Housing Act (2010). We found that the shock substantially increases the likelihood of family homelessness, particularly in cities with high housing costs. The findings are consistent with the economic theory of homelessness, which posits that homelessness results from a conjunction of adverse circumstances in which housing markets and individual characteristics collide. PMID:23868747

  15. Life after Introductory Astronomy

    NASA Astrophysics Data System (ADS)

    McNamara, B.; Hameed, S.

    2000-12-01

    Beginning astronomy is a popular class for undergraduates, and a fair percentage of these students would take another nontechnical class in this field if one were available. What other courses exist for students to take after introductory astronomy? At NMSU we offer three classes that enroll large numbers of juniors/seniors who are nonscience majors. These classes are (1) Into the Final Frontier: the Human Exploration of Space, (2) The Search for Life in the Universe, (3) and Revolutionary Ideas in Science. Curricula for these classes, teaching strategies, and course materials will be provided in this poster presentation for those wishing to offer similar classes at their institutions. Some of th work presented in this poster was support by the NSF and NASA

  16. Airframe life prediction

    NASA Technical Reports Server (NTRS)

    Sendeckyj, G. P.

    1992-01-01

    The required research to develop improved life prediction methods for metallic and composite structures under severe thermomechanical loading must include the development of a verified thermoinelastic fracture criterion. There has been much work in this area with many fracture criteria being proposed. Due to the lack of adequate experimental verification none of them are widely accepted. Research must also be performed to develop and implement improved thermoinelasticity theories that properly model large temperature excursions and high temperature gradient. This research is required to provide confidence in the simpler theories currently used for thermoinelastic analysis. Finally, experimental data is needed to define the behavior of and damage accumulation process in thermoinelastic materials. Special emphasis must be placed on understanding failure mode transitions under thermomechanical loading conditions.

  17. A Survey of Health-Related Activities on Second Life

    PubMed Central

    Beard, Leslie; Wilson, Kumanan; Morra, Dante

    2009-01-01

    Background Increasingly, governments, health care agencies, companies, and private groups have chosen Second Life as part of their Web 2.0 communication strategies. Second Life offers unique design features for disseminating health information, training health professionals, and enabling patient education for both academic and commercial health behavior research. Objectives This study aimed to survey and categorize the range of health-related activities on Second Life; to examine the design attributes of the most innovative and popular sites; and to assess the potential utility of Second Life for the dissemination of health information and for health behavior change. Methods We used three separate search strategies to identify health-related sites on Second Life. The first used the application’s search engine, entering both generic and select illness-specific keywords, to seek out sites. The second identified sites through a comprehensive review of print, blog, and media sources discussing health activities on Second Life. We then visited each site and used a snowball method to identify other health sites until we reached saturation (no new health sites were identified). The content, user experience, and chief purpose of each site were tabulated as well as basic site information, including user traffic data and site size. Results We found a wide range of health-related activities on Second Life, and a diverse group of users, including organizations, groups, and individuals. For many users, Second Life activities are a part of their Web 2.0 communication strategy. The most common type of health-related site in our sample (n = 68) were those whose principle aim was patient education or to increase awareness about health issues. The second most common type of site were support sites, followed by training sites, and marketing sites. Finally, a few sites were purpose-built to conduct research in SL or to recruit participants for real-life research. Conclusions Studies

  18. The illusion of invariant quantities in life histories.

    PubMed

    Nee, Sean; Colegrave, Nick; West, Stuart A; Grafen, Alan

    2005-08-19

    Life-history theory attempts to provide evolutionary explanations for variations in the ways in which animal species live their lives. Recent analyses have suggested that the dimensionless ratios of several key life-history parameters are the same for different species, even across distant taxa. However, we show here that previous analyses may have given a false picture and created an illusion of invariants, which do not necessarily exist; essentially, this is because life-history variables have been regressed against themselves. The following question arises from our analysis: How do we identify an invariant? PMID:16109879

  19. Identifying and managing Hymenoptera venom allergy.

    PubMed

    Matron, Patricia Kane; Timms, Victoria; Fitzsimons, Roisin

    2016-05-25

    Hymenoptera venom allergy is an immunoglobulin E (IgE)-mediated hypersensitivity to the venom of insects from the Hymenoptera order and is a common cause of anaphylaxis. A diagnosis of venom allergy is made by taking an accurate medical, family and social history, alongside specific allergy testing. Systemic reactions to Hymenoptera venom occur in a small proportion of the population; these range from mild to life-threatening in severity. Treatment for local reactions involves the use of cold packs, antihistamines, analgesia and topical corticosteroids to help alleviate swelling, pain and pruritus. Venom immunotherapy is the treatment of choice for reducing the incidence of future anaphylactic reactions in individuals who have signs of respiratory obstruction or hypotension. Venom immunotherapy is the most effective treatment in reduction of life-threatening reactions to venom, and can improve quality of life for individuals. Treatment should only be provided by experienced staff who are able to provide emergency care for anaphylaxis and life-threatening episodes. A risk assessment to deliver treatment should be undertaken before treatment is commenced. PMID:27224630

  20. Labeled line drawing of launch and entry suit identifies various components

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Line drawings illustrate the front and back of the space shuttle launch and entry suit (LES) and labels identify various components. LES was designed for STS-26, the return to flight mission, and subsequent missions. Included in the crew escape system (CES) package are launch and entry helmet (LEH) with communications carrier (COMM CAP), parachute pack and harness, life preserver unit (LPU), life raft unit (LRU), LES gloves, suit oxygen manifold and valves, boots, and survival gear. Details of larger components are also identified.

  1. USSR Space Life Sciences Digest, issue 25

    NASA Technical Reports Server (NTRS)

    Hooke, Lydia Razran (Editor); Teeter, Ronald (Editor); Garshnek, Victoria (Editor); Rowe, Joseph (Editor)

    1990-01-01

    This is the twenty-fifth issue of NASA's Space Life Sciences Digest. It contains abstracts of 42 journal papers or book chapters published in Russian and of 3 Soviet monographs. Selected abstracts are illustrated with figures and tables from the original. The abstracts in this issue have been identified as relevant to 26 areas of space biology and medicine. These areas include: adaptation, body fluids, botany, cardiovascular and respiratory systems, developmental biology, endocrinology, enzymology, equipment and instrumentation, exobiology, gravitational biology, habitability and environmental effects, human performance, immunology, life support systems, man-machine systems, mathematical modeling, metabolism, microbiology, musculoskeletal system, neurophysiology, nutrition, operational medicine, psychology, radiobiology, reproductive system, and space biology and medicine.

  2. USSR Space Life Sciences Digest, issue 29

    NASA Technical Reports Server (NTRS)

    Stone, Lydia Razran (Editor); Teeter, Ronald (Editor); Rowe, Joseph (Editor)

    1991-01-01

    This is the twenty-ninth issue of NASA's Space Life Sciences Digest. It is a double issue covering two issues of the Soviet Space Biology and Aerospace Medicine Journal. Issue 29 contains abstracts of 60 journal papers or book chapters published in Russian and of three Soviet monographs. Selected abstracts are illustrated with figures and tables from the original. A review of a book on environmental hygiene and a list of papers presented at a Soviet conference on space biology and medicine are also included. The materials in this issue were identified as relevant to 28 areas of space biology and medicine. The areas are: adaptation, aviation medicine, biological rhythms, body fluids, botany, cardiovascular and respiratory systems, developmental biology, digestive system, endocrinology, equipment and instrumentation, genetics, habitability and environment effects, hematology, human performance, immunology, life support systems, mathematical modeling, metabolism, musculoskeletal system, neurophysiology, nutrition, personnel selection, psychology, radiobiology, reproductive system, space biology and medicine, and the economics of space flight.

  3. Accommodating life sciences on the Space Station

    NASA Technical Reports Server (NTRS)

    Arno, Roger D.

    1987-01-01

    The NASA Ames Research Center Biological Research Project (BRP) is responsible for identifying and accommodating high priority life science activities, utilizing nonhuman specimens, on the Space Station and is charged to bridge the gap between the science community and the Space Station Program. This paper discusses the approaches taken by the BRP in accomodating these research objectives to constraints imposed by the Space Station System, while maintaining a user-friendly environment. Consideration is given to the particular research disciplines which are given priority, the science objectives in each of these disciplines, the functions and activities required by these objectives, the research equipment, and the equipment suits. Life sciences programs planned by the Space Station participating partners (USA, Europe, Japan, and Canada) are compared.

  4. USSR Space Life Sciences Digest, issue 19

    NASA Technical Reports Server (NTRS)

    Hooke, Lydia Razran (Editor); Donaldson, P. Lynn (Editor); Teeter, Ronald (Editor); Garshnek, Victoria (Editor); Rowe, Joseph (Editor)

    1988-01-01

    This is the 19th issue of NASA's USSR Space Life Sciences Digest. It contains abstracts of 47 papers published in Russian language periodicals or presented at conferences and of 5 new Soviet monographs. Selected abstracts are illustrated with figures and tables from the original. Reports on two conferences, one on adaptation to high altitudes, and one on space and ecology are presented. A book review of a recent work on high altitude physiology is also included. The abstracts in this issue have been identified as relevant to 33 areas of space biology and medicine. These areas are: adaptation, biological rhythms, biospherics, body fluids, botany, cardiovascular and respiratory systems, cytology, developmental biology, endocrinology, enzymology, biology, group dynamics, habitability and environmental effects, hematology, human performance, immunology, life support systems, man-machine systems, mathematical modeling, metabolism, microbiology, musculoskeletal system, neurophysiology, nutrition, operational medicine, perception, personnel selection, psychology, radiobiology, and space biology and medicine.

  5. USSR Space Life Sciences Digest, issue 15

    NASA Technical Reports Server (NTRS)

    Hooke, Lydia Razran (Editor); Teeter, Ronald (Editor); Garshnek, Victoria (Editor); Rowe, Joseph (Editor)

    1988-01-01

    This is the 15th issue of NASA's USSR Space Life Sciences Digest. It contains abstracts of 59 papers published in Russian language periodicals or presented at conferences and of two new Soviet monographs. Selected abstracts are illustrated with figures and tables from the original. An additional feature is a review of a conference devoted to the physiology of extreme states. The abstracts included in this issue have been identified as relevant to 29 areas of space biology and medicine. These areas are adaptation, biological rhythms, biospherics, body fluids, botany, cardiovascular and respiratory systems, endocrinology, enzymology, equipment and instrumentation, exobiology, genetics, habitability and environment effects, human performance, immunology, life support systems, mathematical modeling, metabolism, microbiology, musculoskeletal system, neurophysiology, nutrition, operational medicine, perception. personnel selection, psychology, radiobiology, reproductive biology, and space biology and medicine.

  6. Controlled ecological life support system: Transportation analysis

    NASA Technical Reports Server (NTRS)

    Gustan, E.; Vinopal, T.

    1982-01-01

    This report discusses a study utilizing a systems analysis approach to determine which NASA missions would benefit from controlled ecological life support system (CELSS) technology. The study focuses on manned missions selected from NASA planning forecasts covering the next half century. Comparison of various life support scenarios for the selected missions and characteristics of projected transportation systems provided data for cost evaluations. This approach identified missions that derived benefits from a CELSS, showed the magnitude of the potential cost savings, and indicated which system or combination of systems would apply. This report outlines the analytical approach used in the evaluation, describes the missions and systems considered, and sets forth the benefits derived from CELSS when applicable.

  7. USSR Space Life Sciences Digest, issue 21

    NASA Technical Reports Server (NTRS)

    Hooke, Lydia Razran; Donaldson, P. Lynn; Garshnek, Victoria; Rowe, Joseph

    1989-01-01

    This is the twenty-first issue of NASA's USSR Space Life Sciences Digest. It contains abstracts of 37 papers published in Russian language periodicals or books or presented at conferences and of a Soviet monograph on animal ontogeny in weightlessness. Selected abstracts are illustrated with figures and tables from the original. A book review of a work on adaptation to stress is also included. The abstracts in this issue have been identified as relevant to 25 areas of space biology and medicine. These areas are: adaptation, biological rhythms, body fluids, botany, cardiovascular and respiratory systems, cytology, developmental biology, endocrinology, enzymology, equipment and instrumentation, exobiology, gravitational biology, habitability and environmental effects, hematology, human performance, life support systems, mathematical modeling, metabolism, microbiology, musculoskeletal system, neurophysiology, operational medicine, perception, psychology, and reproductive system.

  8. USSR Space Life Sciences Digest, Issue 10

    NASA Technical Reports Server (NTRS)

    Hooke, Lydia Razran; Radtke, Mike; Teeter, Ronald; Garshnek, Victoria; Rowe, Joseph E.

    1987-01-01

    The USSR Space Life Sciences Digest contains abstracts of 37 papers recently published in Russian language periodicals and bound collections and of five new Soviet monographs. Selected abstracts are illustrated with figures and tables from the original. Additional features include the translation of a book chapter concerning use of biological rhythms as a basis for cosmonaut selection, excerpts from the diary of a participant in a long-term isolation experiment, and a picture and description of the Mir space station. The abstracts included in this issue were identified as relevant to 25 areas of aerospace medicine and space biology. These areas are adaptation, biological rhythms, biospherics, body fluids, botany, cardiovascular and respiratory systems, developmental biology, endocrinology, enzymology, group dynamics, habitability and environmental effects, hematology, human performance, immunology, life support systems, mathematical modeling, metabolism, microbiology, morphology and cytology, musculosketal system, neurophysiology, nutrition, personnel selection, psychology, and radiobiology.

  9. USSR Space Life Sciences Digest, Issue 18

    NASA Technical Reports Server (NTRS)

    Hooke, Lydia Razran (Editor); Donaldson, P. Lynn (Editor); Teeter, Ronald (Editor); Garshnek, Victoria (Editor); Rowe, Joseph (Editor)

    1988-01-01

    This is the 18th issue of NASA's USSR Life Sciences Digest. It contains abstracts of 50 papers published in Russian language periodicals or presented at conferences and of 8 new Soviet monographs. Selected abstracts are illustrated with figures and tables from the original. A review of a recent Aviation Medicine Handbook is also included. The abstracts in this issue have been identified as relevant to 37 areas of space biology and medicine. These areas are: adaptation, aviation medicine, biological rhythms, biospherics, body fluids, cardiovascular and respiratory systems, cytology, developmental biology, endocrinology, enzymology, equipment and instrumentation, exobiology, gastrointestinal system, genetics, gravitational biology, group dynamics, habitability and environmental effects, hematology, human performance, immunology, life support systems, man-machine systems, mathematical modeling, metabolism, microbiology, musculoskeletal system, neurophysiology, nutrition, operational medicine, perception, personnel selection, psychology, radiobiology, reproductive biology, space biology and medicine, and space industrialization.

  10. USSR Space Life Sciences Digest, issue 7

    NASA Technical Reports Server (NTRS)

    Hooke, L. R. (Editor); Teeter, R. (Editor); Teeter, R. (Editor); Teeter, R. (Editor); Teeter, R. (Editor); Teeter, R. (Editor)

    1986-01-01

    This is the seventh issue of NASA's USSR Space Life Sciences Digest. It contains abstracts of 29 papers recently published in Russian language periodicals and bound collections and of 8 new Soviet monographs. Selected abstracts are illustrated with figures and tables from the original. Additional features include two interviews with the Soviet Union's cosmonaut physicians and others knowledgable of the Soviet space program. The topics discussed at a Soviet conference on problems in space psychology are summarized. Information about English translations of Soviet materials available to readers is provided. The topics covered in this issue have been identified as relevant to 29 areas of aerospace medicine and space biology. These areas are adaptation, biospherics, body fluids, botany, cardiovascular and respiratory systems, developmental biology, endocrinology, enzymology, exobiology, genetics, habitability and environment effects, hematology, human performance, immunology, life support systems, mathematical modeling, metabolism, microbiology, morphology and cytology, musculoskeletal system, neurophysiology, nutrition, perception, personnel selection, psychology, radiobiology, and space medicine.

  11. USSR Space Life Sciences Digest, issue 6

    NASA Technical Reports Server (NTRS)

    Hooke, L. R. (Editor); Radtke, M. (Editor); Teeter, R. (Editor); Rowe, J. E. (Editor)

    1986-01-01

    This is the sixth issue of NASA's USSR Space Life Sciences Digest. It contains abstracts of 54 papers recently published in Russian language periodicals and bound collections and of 10 new Soviet monographs. Selected abstracts are illustrated with figures and tables from the original. Additional features include a table of Soviet EVAs and information about English translations of Soviet materials available to readers. The topics covered in this issue have been identified as relevant to 26 areas of aerospace medicine and space biology. These areas are adaptation, biospherics, body fluids, botany, cardiovascular and respiratory systems, developmental biology, endocrinology, enzymology, exobiology, genetics, habitability and environment effects, health and medical treatment, hematology, human performance, immunology, life support systems, mathematical modeling, metabolism., microbiology, morphology and cytology, musculoskeletal system, neurophysiology, nutrition, perception, personnel selection, psychology, radiobiology, reproductive biology, and space medicine.

  12. Life on other worlds : the twentieth century extraterrestrial life debate

    NASA Astrophysics Data System (ADS)

    Dick, Steven J.

    1998-12-01

    List of illustrations; List of tables; Acknowledgements; Introduction; 1. From the physical world to the biological universe: Democritus to Lowell; 2. Life in the solar system; 3. Solar systems beyond; 4. Extraterrestrials in literature and the arts: the role of imagination; 5. The UFO controversy and the extraterrestrial hypothesis; 6. The origin and evolution of life in the extraterrestrial context; 7. SETI: the search for extraterrestrial intelligence; 8. The meaning of life; 9. Summary and conclusion: the biological universe; Select bibliographical essay; Index.

  13. Solid tags for identifying failed reactor components

    DOEpatents

    Bunch, Wilbur L.; Schenter, Robert E.

    1987-01-01

    A solid tag material which generates stable detectable, identifiable, and measurable isotopic gases on exposure to a neutron flux to be placed in a nuclear reactor component, particularly a fuel element, in order to identify the reactor component in event of its failure. Several tag materials consisting of salts which generate a multiplicity of gaseous isotopes in predetermined ratios are used to identify different reactor components.

  14. The value of life and the value of life extension.

    PubMed

    Horrobin, Steven

    2006-05-01

    Recent developments in aging research have added new urgency to the bioethical debate concerning life and death issues, the value of life, and the reasonable limits of medicine. This paper analyzes the basic structures of the liberal and conservative components of this debate, showing that there has hitherto been inadequate analysis on both sides concerning the nature and implications of the value of life, as well as, and as distinct from the value of life extension. Classic concepts of the intrinsic or extrinsic value of life are argued to be tangential or actually irrelevant to the value of life's continuance and so to the value of life extension. An analysis of personhood is proposed which focuses explicitly upon the value of life extension to persons. This analysis shows that persons may only intelligibly be understood as processes, for whom life extension is an inalienable and fundamental value. It is further proposed that, properly understood, such an analysis may significantly narrow the liberal/conservative divide in bioethics. PMID:16803974

  15. Identifying Fracture Types and Relative Ages Using Fluid Inclusion Stratigraphy

    SciTech Connect

    Dilley, Lorie M.; Norman, David; Owens, Lara

    2008-06-30

    Enhanced Geothermal Systems (EGS) are designed to recover heat from the subsurface by mechanically creating fractures in subsurface rocks. Understanding the life cycle of a fracture in a geothermal system is fundamental to the development of techniques for creating fractures. Recognizing the stage of a fracture, whether it is currently open and transmitting fluids; if it recently has closed; or if it is an ancient fracture would assist in targeting areas for further fracture stimulation. Identifying dense fracture areas as well as large open fractures from small fracture systems will also assist in fracture stimulation selection. Geothermal systems are constantly generating fractures, and fluids and gases passing through rocks in these systems leave small fluid and gas samples trapped in healed microfractures. Fluid inclusions trapped in minerals as the fractures heal are characteristic of the fluids that formed them, and this signature can be seen in fluid inclusion gas analysis. Our hypothesis is that fractures over their life cycle have different chemical signatures that we can see in fluid inclusion gas analysis and by using the new method of fluid inclusion stratigraphy (FIS) the different stages of fractures, along with an estimate of fracture size can be identified during the well drilling process. We have shown with this study that it is possible to identify fracture locations using FIS and that different fractures have different chemical signatures however that signature is somewhat dependent upon rock type. Open, active fractures correlate with increase concentrations of CO2, N2, Ar, and to a lesser extent H2O. These fractures would be targets for further enhancement. The usefulness of this method is that it is low cost alternative to current well logging techniques and can be done as a well is being drilled.

  16. Helping You Identify Quality Laboratory Services

    MedlinePlus

    Helping You Identify Quality Laboratory Services Selecting quality health care services for yourself, a relative or friend requires special thought and attention. The Joint Commission has prepared ...

  17. Origins and Evolution of Life

    NASA Astrophysics Data System (ADS)

    Gargaud, Muriel; López-García, Purificación; Martin, Hervé

    2011-01-01

    Part I. What Is Life?: 1. Problems raised by a definition of life M. Morange; 2. Some remarks about uses of cosmological anthropic 'principles' D. Lambert; 3. Minimal cell: the biologist point of view C. Brochier-Armanet; 4. Minimal cell: the computer scientist point of view H. Bersini; 5. Origins of life: computing and simulation approaches B. Billoud; Part II. Astronomical and Geophysical Context of the Emergence of Life: 6. Organic molecules in interstellar medium C. Ceccarelli and C. Cernicharo; 7. Cosmochemical evolution and the origin of life: insights from meteorites S. Pizzarello; 8. Astronomical constraints on the emergence of life M. Gounelle and T. Montmerle; 9. Formation of habitable planets J. Chambers; 10. The concept of galactic habitable zone N. Prantzos; 11. The young Sun and its influence on planetary atmospheres M. Güdel and J. Kasting; 12. Climates of the Earth G. Ramstein; Part III. Role of Water in the Emergence of Life: 13. Liquid water: a necessary condition to all forms of life K. Bartik, G. Bruylants, E. Locci and J. Reisse; 14. The role of water in the formation and evolution of planets T. Encrenaz; 15. Water on Mars J. P. Bibring; Part IV. From Non-Living Systems to Life: 16. Energetic constraints on prebiotic pathways: application to the emergence of translation R. Pascal and L. Boiteau; 17. Comparative genomics and early cell evolution A. Lazcano; 18. Origin and evolution of metabolisms J. Peretó; Part V. Mechanisms for Life Evolution: 19. Molecular phylogeny: inferring the patterns of evolution E. Douzery; 20. Horizontal gene transfer: mechanisms and evolutionary consequences D. Moreira; 21. The role of symbiosis in eukaryotic evolution A. Latorre, A. Durbán, A. Moya and J. Peretó; Part VI. Life in Extreme Conditions: 22. Life in extreme conditions: Deinococcus radiodurans, an organism able to survive prolonged desiccation and high doses of ionising radiation S. Sommer and M. Toueille; 23. Molecular effects of UV and ionizing

  18. Defining life: synthesis and conclusions.

    PubMed

    Gayon, Jean

    2010-04-01

    The first part of the paper offers philosophical landmarks on the general issue of defining life. Section 1 defends that the recognition of "life" has always been and remains primarily an intuitive process, for the scientist as for the layperson. However we should not expect, then, to be able to draw a definition from this original experience, because our cognitive apparatus has not been primarily designed for this. Section 2 is about definitions in general. Two kinds of definition should be carefully distinguished: lexical definitions (based upon current uses of a word), and stipulative or legislative definitions, which deliberately assign a meaning to a word, for the purpose of clarifying scientific or philosophical arguments. The present volume provides examples of these two kinds of definitions. Section 3 examines three traditional philosophical definitions of life, all of which have been elaborated prior to the emergence of biology as a specific scientific discipline: life as animation (Aristotle), life as mechanism, and life as organization (Kant). All three concepts constitute a common heritage that structures in depth a good deal of our cultural intuitions and vocabulary any time we try to think about "life". The present volume offers examples of these three concepts in contemporary scientific discourse. The second part of the paper proposes a synthesis of the major debates developed in this volume. Three major questions have been discussed. A first issue (Section 4) is whether we should define life or not, and why. Most authors are skeptical about the possibility of defining life in a strong way, although all admit that criteria are useful in contexts such as exobiology, artificial life and the origins of life. Section 5 examines the possible kinds of definitions of life presented in the volume. Those authors who have explicitly defended that a definition of life is needed, can be classified into two categories. The first category (or standard view) refers

  19. Measuring quality of life in muscular dystrophy

    PubMed Central

    Abresch, Richard T.; Biesecker, Barbara; Conway, Kristin Caspers; Heatwole, Chad; Peay, Holly; Scal, Peter; Strober, Jonathan; Uzark, Karen; Wolff, Jodi; Margolis, Marjorie; Blackwell, Angela; Street, Natalie; Montesanti, Angela; Bolen, Julie

    2015-01-01

    Objectives: The objectives of this study were to develop a conceptual model of quality of life (QOL) in muscular dystrophies (MDs) and review existing QOL measures for use in the MD population. Methods: Our model for QOL among individuals with MD was developed based on a modified Delphi process, literature review, and input from patients and patient advocacy organizations. Scales that have been used to measure QOL among patients with MD were identified through a literature review and evaluated using the COSMIN (Consensus-Based Standards for the Selection of Health Measurement Instruments) checklist. Results: The Comprehensive Model of QOL in MD (CMQM) captures 3 broad domains of QOL (physical, psychological, and social), includes factors influencing self-reported QOL (disease-related factors, support/resources, and expectations/aspirations), and places these concepts within the context of the life course. The literature review identified 15 QOL scales (9 adult and 6 pediatric) that have been applied to patients with MD. Very few studies reported reliability data, and none included data on responsiveness of the measures to change in disease progression, a necessary psychometric property for measures included in treatment and intervention studies. No scales captured all QOL domains identified in the CMQM model. Conclusions: Additional scale development research is needed to enhance assessment of QOL for individuals with MD. Item banking and computerized adaptive assessment would be particularly beneficial by allowing the scale to be tailored to each individual, thereby minimizing respondent burden. PMID:25663223

  20. Life's chirality from prebiotic environments

    NASA Astrophysics Data System (ADS)

    Gleiser, Marcelo; Walker, Sara Imari

    2012-10-01

    A key open question in the study of life is the origin of biomolecular homochirality: almost every life-form on Earth has exclusively levorotary amino acids and dextrorotary sugars. Will the same handedness be preferred if life is found elsewhere? We review some of the pertinent literature and discuss recent results suggesting that life's homochirality resulted from sequential chiral symmetry breaking triggered by environmental events. In one scenario, autocatalytic prebiotic reactions undergo stochastic fluctuations due to environmental disturbances, in a mechanism reminiscent of evolutionary punctuated equilibrium: short-lived destructive events may lead to long-term enantiomeric excess. In another, chiral-selective polymerization reaction rates influenced by environmental effects lead to substantial chiral excess even in the absence of autocatalysis. Applying these arguments to other potentially life-bearing platforms has implications to the search for extraterrestrial life: we predict that a statistically representative sampling of extraterrestrial stereochemistry will be racemic (chirally neutral) on average.

  1. Extended mission life support systems

    NASA Technical Reports Server (NTRS)

    Quattrone, P. D.

    1985-01-01

    Extended manned space missions which include interplanetary missions require regenerative life support systems. Manned mission life support considerations are placed in perspective and previous manned space life support system technology, activities and accomplishments in current supporting research and technology (SR&T) programs are reviewed. The life support subsystem/system technologies required for an enhanced duration orbiter (EDO) and a space operations center (SOC), regenerative life support functions and technology required for manned interplanetary flight vehicles, and future development requirements are outlined. The Space Shuttle Orbiters (space transportation system) is space cabin atmosphere is maintained at Earth ambient pressure of 14.7 psia (20% O2 and 80% N2). The early Shuttle flights will be seven-day flights, and the life support system flight hardware will still utilize expendables.

  2. Halophilic life on Mars ?

    NASA Astrophysics Data System (ADS)

    Stan-Lotter, Helga; Fendrihan, Sergiu; Dornmayr-Pfaffenhuemer, Marion; Holzinger, Anita; Polacsek, Tatjana K.; Legat, Andrea; Grösbacher, Michael; Weigl, Andreas

    2010-05-01

    Background: The search for extraterrestrial life has been declared as a goal for the 21th century by several space agencies. Potential candidates are microorganisms on or in the surface of moons and planets, such as Mars. Extremely halophilic archaea (haloarchaea) are of astrobiological interest since viable strains have been isolated from million years old salt deposits (1) and halite has been found in Martian meteorites and in surface pools. Therefore, haloarchaeal responses to simulated and real space conditions were explored. Immuno assays for a potential Life Marker Chip experiment were developed with antisera against the universal enzyme ATP synthase. Methods: The focus of these studies was on the application of fluorescent probes since they provide strong signals, and detection devices are suitable for miniaturization. Viability of haloarchaeal strains (Halococcus dombrowskii and Halobacterium salinarum NRC-1) was probed with the LIVE/DEAD BacLight™ kit and the BacLight™ Bacterial Membrane Potential kit. Cyclobutane pyrimidine dimers (CPD) in the DNA, following exposure to simulated and real space conditions (UV irradiation from 200 - 400 nm; 18 months exposure on the International Space Station [ISS] within the ADAPT experiment by Dr. P. Rettberg), were detected with fluorescent Alexa-Fluor-488-coupled antibodies. Immuno assays with antisera against the A-ATPase subunits from Halorubrum saccharovorum were carried out with the highly sensitive Immun-Star ™ WesternC ™ chemiluminescent kit (Bio-Rad). Results: Using the LIVE/DEAD BacLight™ kit, the D37 (dose of 37% survival) for Hcc. dombrowskii and Hbt. salinarum NRC-1, following exposure to UV (200-400 nm) was about 400 kJ/m2, when cells were embedded in halite and about 1 kJ/m2, when cells were in liquid cultures. Fluorescent staining indicated a slightly higher cellular activity than that which was derived from the determination of colony forming units. Assessment of viability with the Bac

  3. Planetary Evolution, Habitability and Life

    NASA Astrophysics Data System (ADS)

    Tilman, Spohn; Breuer, Doris; de Vera, Jean-Pierre; Jaumann, Ralf; Kuehrt, Ekkehard; Möhlmann, Diedrich; Rauer, Heike; Richter, Lutz

    A Helmholtz Alliance has been established to study the interactions between life and the evo-lution of planets. The approach goes beyond current studies in Earth-System Sciences by including the entire planet from the atmosphere to the deep interior, going beyond Earth to include other Earth-like planets such as Mars and Venus and satellites in the solar system where ecosystems may exist underneath thick ice shells,considering other solar systems. The approach includes studies of the importance of plate tectonics and other tectonic regimes such as single plate tectonics for the development and for sustaining life and asks the question: If life can adapt to a planet, can a planet adapt to life? Can life be seen as a geological process and if so, can life shape the conditions on a planet such that life can flourish? The vision goes beyond the solar system by including the challenges that life would face in other solar systems. The Alliance uses theoretical modelling of feedback cycles and coupled planetary atmosphere and interior processes. These models are based on the results of remote sensing of planetary surfaces and atmospheres, laboratory studies on (meteorite) samples from other planets and on studies of life under extreme conditions. The Alliance uses its unique capabilities in remote sensing and in-situ exploration to prepare for empirical studies of the parameters affecting habitability. The Alliance aims to establish a network infrastructure in Germany to enable the most ad-vanced research in planetary evolution studies by including life as a planetary process. Finding extraterrestrial life is a task of fundamental importance to mankind, and its fulfilment will be philosophically profound. Evaluating the interactions between planetary evolution and life will help to put the evolution of our home planet (even anthropogenic effects) into perspective.

  4. Life in a ligand sphere.

    PubMed Central

    Wächtershäuser, G

    1994-01-01

    The most fundamental divide in biology is that between heterotrophic and autotrophic ways of life. Two of the leading proponents of a heterotrophic origin of life ("hetero-origin") in a prebiotic broth, C. de Duve and S. L. Miller, have criticized my theory of a pyrite-pulled chemo-autotrophic origin of life ("auto-origin") [De Duve, C. & Miller, S. L. (1991) Proc. Natl. Acad. Sci. USA 88, 10014-10017]. This criticism is now answered. PMID:8183902

  5. [Quality of life and fate].

    PubMed

    Spaemann, C

    1992-01-01

    While the term "happiness of life", the "eudaimonia" of the greek philosophers, includes the good as such and therefore a metaphysical and moral component, the modern term of the "quality of life" is wholly defined by the criteria of a person's functional capacity and subjective wellbeing. The doctor's orientation by these criteria meets its limits, where he is confronted with fatality. This shows that we cannot really comprehend the quality of life without man's fundamental task of mastering his fate. PMID:1296397

  6. Biological life-support systems

    NASA Technical Reports Server (NTRS)

    Shepelev, Y. Y.

    1975-01-01

    The establishment of human living environments by biologic methods, utilizing the appropriate functions of autotrophic and heterotrophic organisms is examined. Natural biologic systems discussed in terms of modeling biologic life support systems (BLSS), the structure of biologic life support systems, and the development of individual functional links in biologic life support systems are among the factors considered. Experimental modeling of BLSS in order to determine functional characteristics, mechanisms by which stability is maintained, and principles underlying control and regulation is also discussed.

  7. Studies of Life on Earth are Important for Mars Exploration

    NASA Technical Reports Server (NTRS)

    DesMarais, D. J.

    1998-01-01

    The search for evidence of the early martian environment and a martian biosphere is benefitted by diverse studies of life on Earth. Most fundamentally, origin-of-life research highlights the challenge in formulating a rigorous definition of life. Because such definitions typically list several of life's most basic properties, they also help to define those observable features that distinguish life and thus might be sought through telescopes, spacecraft, and analyses of extraterrestrial samples. Studies of prebiotic chemistry also help by defining the range of environments and processes that sustain prebiotic organic synthesis. These studies might indicate if and where prebiotic processes occur today on Earth and elsewhere. Such studies should also help to identify which localities are good candidates for the origin of life. A better understanding of the most fundamental principles by which molecules are assembled into living systems will help us to appreciate possible alternatives to the path followed by life on Earth. These perspectives will sharpen our ability to recognize exotic life and/or those environments that can sustain it.

  8. Life extending control: A concept paper

    NASA Technical Reports Server (NTRS)

    Lorenzo, Carl F.; Merrill, Walter C.

    1991-01-01

    The concept of Life Extending Control is defined. Life is defined in terms of mechanical fatigue life. A brief description is given of the current approach to life prediction using a local, cyclic, stress-strain approach for a critical system component. An alternative approach to life prediction based on a continuous functional relationship to component performance is proposed.Base on cyclic life prediction an approach to Life Extending Control, called the Life Management Approach is proposed. A second approach, also based on cyclic life prediction, called the Implicit Approach, is presented. Assuming the existence of the alternative functional life prediction approach, two additional concepts for Life Extending Control are presented.

  9. Identifying Information Focuses in Listening Comprehension

    ERIC Educational Resources Information Center

    Zhang, Hong-yan

    2011-01-01

    The study explains the process of learners' listening comprehension within Halliday's information theory in functional grammar, including the skills of identifying focuses while listening in college English teaching. Identifying information focuses in listening is proved to improve the students' communicative listening ability by the means of a…

  10. Identifying Bilingual Semantic Neural Representations across Languages

    ERIC Educational Resources Information Center

    Buchweitz, Augusto; Shinkareva, Svetlana V.; Mason, Robert A.; Mitchell, Tom M.; Just, Marcel Adam

    2012-01-01

    The goal of the study was to identify the neural representation of a noun's meaning in one language based on the neural representation of that same noun in another language. Machine learning methods were used to train classifiers to identify which individual noun bilingual participants were thinking about in one language based solely on their…

  11. 29 CFR 4010.7 - Identifying information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Identifying information. 4010.7 Section 4010.7 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION CERTAIN REPORTING AND DISCLOSURE REQUIREMENTS ANNUAL FINANCIAL AND ACTUARIAL INFORMATION REPORTING § 4010.7 Identifying...

  12. 29 CFR 4010.7 - Identifying information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Identifying information. 4010.7 Section 4010.7 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION CERTAIN REPORTING AND DISCLOSURE REQUIREMENTS ANNUAL FINANCIAL AND ACTUARIAL INFORMATION REPORTING § 4010.7 Identifying...

  13. 29 CFR 4010.7 - Identifying information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Identifying information. 4010.7 Section 4010.7 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION CERTAIN REPORTING AND DISCLOSURE REQUIREMENTS ANNUAL FINANCIAL AND ACTUARIAL INFORMATION REPORTING § 4010.7 Identifying...

  14. 29 CFR 4010.7 - Identifying information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Identifying information. 4010.7 Section 4010.7 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION CERTAIN REPORTING AND DISCLOSURE REQUIREMENTS ANNUAL FINANCIAL AND ACTUARIAL INFORMATION REPORTING § 4010.7 Identifying...

  15. Portable Radiometer Identifies Minerals in the Field

    NASA Technical Reports Server (NTRS)

    Goetz, A. F. H.; Machida, R. A.

    1982-01-01

    Hand-held optical instrument aids in identifying minerals in field. Can be used in exploration for minerals on foot or by aircraft. The radiometer is especially suitable for identifying clay and carbonate minerals. Radiometer measures reflectances of mineral at two wavelengths, computes ratio of reflectances, and displays ratio to user.

  16. Self-Identifying Emergency Radio Beacons

    NASA Technical Reports Server (NTRS)

    Friedman, Morton L.

    1987-01-01

    Rescue teams aided by knowledge of vehicle in distress. Similar to conventional emergency transmitters except contains additional timing and modulating circuits. Additions to standard emergency transmitter enable transmitter to send rescuers identifying signal in addition to conventional distress signal created by sweep generator. Data generator contains identifying code.

  17. The ethics of life expectancy.

    PubMed

    Small, Robin

    2002-08-01

    Some ethical dilemmas in health care, such as over the use of age as a criterion of patient selection, appeal to the notion of life expectancy. However, some features of this concept have not been discussed. Here I look in turn at two aspects: one positive--our expectation of further life--and the other negative--the loss of potential life brought about by death. The most common method of determining this loss, by counting only the period of time between death and some particular age, implies that those who die at ages not far from that one are regarded as losing very little potential life, while those who die at greater ages are regarded as losing none at all. This approach has methodological advantages but ethical disadvantages, in that it fails to correspond to our strong belief that anyone who dies is losing some period of life that he or she would otherwise have had. The normative role of life expectancy expressed in the 'fair innings' attitude arises from a particular historical situation: not the increase of life expectancy in modern societies, but a related narrowing in the distribution of projected life spans. Since life expectancy is really a representation of existing patterns of mortality, which in turn are determined by many influences, including the present allocation of health resources, it should not be taken as a prediction, and still less as a statement of entitlement. PMID:12956176

  18. Water and Life on Mars

    NASA Technical Reports Server (NTRS)

    McKay, Christopher P.; DeVincenzi, Donald (Technical Monitor)

    2000-01-01

    Mars appears to be cold dry and dead world. However there is good evidence that early in its history it had liquid water, more active volcanism, and a thicker atmosphere. Mars had this earth-like environment over three and a half billion years ago, during the same time that life appeared on Earth. The main question in the exploration of Mars then is the search for a independent origin of life on that planet. Ecosystems in cold, dry locations on Earth - such as the Antarctic - provide examples of how life on Mars might have survived and where to look for fossils. Although the Viking results may indicate that Mars has no life today, there is direct geomorphological evidence that, in the past, Mars had large amounts of liquid water on its surface - possibly due to a thicker atmosphere. From a biological perspective the existence of liquid water, by itself motivates the question of the origin of life on Mars. One of the martian meteorites dates back to this early period and may contain evidence consistent with life. From studies of the Earth's earliest biosphere we know that by 3.5 Gyr. ago, life had originated on Earth and reached a fair degree of biological sophistication. Surface activity and erosion on Earth make it difficult to trace the history of life before the 3.5 Gyr timeframe. Ecosystems in cold, dry locations on Earth - such as the Antarctic - provide examples of how life on Mars might have survived and where to look for fossils.

  19. Originism - Ethics and Extraterrestrial Life

    NASA Astrophysics Data System (ADS)

    Cockell, C. S.

    How should we treat extraterrestrial life, if we ever find it, and does a different origin of life imply a different ethical status? The most likely source of an ethical difference, or `originism,' is the inability to find a coherent definition of `life,' required to assess moral relevance in the first place. Although from a normative point of view biochemical architecture, in itself, does not provide a reason for a difference, there are numerous positions that might encourage us to treat an independent origin of life differently to life that is related to life on Earth. For example, from an instrumental point of view it would provide an opportunity to study another biological data point; it will be a new source of information about the evolution of life, and thus it might be afforded special status. We might consider extraterrestrial life to be special as prudence against the possibility of its mistreatment through an erroneous moral assessment of its worth. Whether extraterrestrial life exists of an independent origin or not, this analysis ultimately can provide a useful device for considering how we should treat entities on Earth whose status as `living' organisms is disputed, specifically viruses.

  20. Recycling and Life Cycle Issues

    SciTech Connect

    Das, Sujit

    2010-01-01

    This chapter addresses recycling and life cycle considerations related to the growing use of lightweight materials in vehicles. The chapter first addresses the benefit of a life cycle perspective in materials choice, and the role that recycling plays in reducing energy inputs and environmental impacts in a vehicle s life cycle. Some limitations of life cycle analysis and results of several vehicle- and fleet-level assessments are drawn from published studies. With emphasis on lightweight materials such as aluminum, magnesium, and polymer composites, the status of the existing recycling infrastructure and technological challenges being faced by the industry also are discussed.

  1. The Search for Extraterrestrial Life

    NASA Astrophysics Data System (ADS)

    Peter, Ulmschneider

    Looking at the nature, origin, and evolution of life on Earth is one way of assessing whether extraterrestrial life exists on Earth-like planets elsewhere (see Chaps. 5 and 6). A more direct approach is to search for favorable conditions and traces of life on other celestial bodies, both in the solar system and beyond. Clearly, there is little chance of encountering nonhuman intelligent beings in the solar system. But there could well be primitive life on Mars, particularly as in the early history of the solar system the conditions on Mars were quite similar to those on Earth. In addition, surprisingly favorable conditions for life once existed on the moons of Jupiter. Yet even if extraterrestrial life is not encountered in forthcoming space missions, it would be of utmost importance to recover fossils of past organisms as such traces would greatly contribute to our basic understanding of the formation of life. In addition to the planned missions to Mars and Europa, there are extensive efforts to search for life outside the solar system. Rapid advances in the detection of extrasolar planets, outlined in Chap. 3, are expected to lead to the discovery of Earth-like planets in the near future. But how can we detect life on these distant bodies?

  2. Identifying early Earth microfossils in unsilicified sediments

    NASA Astrophysics Data System (ADS)

    Javaux, Emmanuelle J.; Asael, Dan; Bekker, Andrey; Debaille, Vinciane; Derenne, Sylvie; Hofmann, Axel; Mattielli, Nadine; Poulton, Simon

    2013-04-01

    The search for life on the early Earth or beyond Earth requires the definition of biosignatures, or "indices of life". These traditionally include fossil molecules, isotopic fractionations, biosedimentary structures and morphological fossils interpreted as remnants of life preserved in rocks. This research focuses on traces of life preserved in unsilicified siliciclastic sediments. Indeed, these deposits preserve well sedimentary structures indicative of past aqueous environments and organic matter, including the original organic walls of microscopic organisms. They also do not form in hydrothermal conditions which may be source of abiotic organics. At our knowledge, the only reported occurrence of microfossils preserved in unsilicified Archean sediments is a population of large organic-walled vesicles discovered in shales and siltstones of the 3.2 Ga Moodies Group, South Africa. (Javaux et al, Nature 2010). These have been interpreted as microfossils based on petrographic and geochemical evidence for their endogenicity and syngeneity, their carbonaceous composition, cellular morphology and ultrastructure, occurrence in populations, taphonomic features of soft wall deformation, and the geological context plausible for life, as well as lack of abiotic explanation falsifying a biological origin. Demonstrating that carbonaceous objects from Archaean rocks are truly old and truly biological is the subject of considerable debate. Abiotic processes are known to produce organics and isotopic signatures similar to life. Spheroidal pseudofossils may form as self-assembling vesicles from abiotic CM, e.g. in prebiotic chemistry experiments (Shoztak et al, 2001), from meteoritic lipids (Deamer et al, 2006), or hydrothermal fluids (Akashi et al, 1996); by artifact of maceration; by migration of abiotic or biotic CM along microfractures (VanZuilen et al, 2007) or along mineral casts (Brasier et al, 2005), or around silica spheres formed in silica-saturated water (Jones and

  3. Globalization and Life History Research: Fragments of a Life Foretold

    ERIC Educational Resources Information Center

    Tierney, William G.

    2010-01-01

    The goal of this paper is to understand, by way of a life history of one low-income working-class youth, how globalization impacts the working class in a developing nation. The concept of globalization and the method of life history seem diametrically opposed. Globalization is an idea about large social forces that impact the economic and material…

  4. Life Development Intervention for Athletes: Life Skills through Sports.

    ERIC Educational Resources Information Center

    Danish, Steven J.; And Others

    1993-01-01

    Describes sport psychology and model for practice consistent with training of counseling psychologists as teachers of life skills. Examines role that sport plays in society and its importance for development of identity and personal competence. Delineates life development intervention (LDI) and psychoeducational model for practice of sport…

  5. Mapping method in life sciences and beyond

    NASA Astrophysics Data System (ADS)

    Molski, Marcin

    2013-10-01

    A mapping procedure applied to conversion of arbitrary differentiable mathematical functions into power ones is characterized. It can be employed to obtain the power law fractal function with parameter dependent exponent identified with fractal dimension of the system under consideration. In this way one may investigate the fractal dynamics of different phenomena in the life sciences and beyond. The generalized fractal function can be used to describe biological processes including: neurogenesis, tumour progression, psychophysical and cognitive learning processes, which can be incorporated into the area of possible applications.

  6. USSR Space Life Sciences Digest, issue 32

    NASA Technical Reports Server (NTRS)

    Stone, Lydia Razran (Editor); Rowe, Joseph (Editor)

    1992-01-01

    This is the thirty-second issue of NASA's USSR Space Life Sciences Digest. It contains abstracts of 34 journal or conference papers published in Russian and of 4 Soviet monographs. Selected abstracts are illustrated with figures and tables from the original. The abstracts in this issue have been identified as relevant to 18 areas of space biology and medicine. These areas include: adaptation, aviation medicine, biological rhythms, biospherics, cardiovascular and respiratory systems, developmental biology, exobiology, habitability and environmental effects, human performance, hematology, mathematical models, metabolism, microbiology, musculoskeletal system, neurophysiology, operational medicine, and reproductive system.

  7. Self Righting Life Raft

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The Givens Buoy Raft was designed and manufactured for inventor Jim Givens of Givens Marine Survival Co. Inc., by RPR Industries, Inc. The Raft consists of a canopied topside and an underwater hemispheric ballast chamber. It has a heavy ballast stabilization system, adopted from NASA technology, which negates the capsizing problem. A "flapper valve" admits large amounts of water to the hemisphere chamber providing ballast to keep the center of gravity constant; stabilization system compensates for changes in wave angle and weight shifting of raft occupants. Mr. Givens has an exclusive patent license for use of the NASA technology. Produced in various sizes, capacities range from six to 20 persons. Raft is housed in a canister, available in several configurations. A pull on a line triggers the automatic inflation process, which takes 12 seconds. The raft has been credited with saving 230 lives in the last five years. It has found wide acceptance with operators of fishing boats, pleasure craft and other vessels. The Coast Guard is purchasing the rafts for use on its rescue helicopters and the Navy has a development program to adapt the system. The Coast Guard last year announced a proposed amendment of its regulations that would require large ballast chambers on inflatable life rafts.

  8. Lanthanides: New life metals?

    PubMed

    Chistoserdova, Ludmila

    2016-08-01

    Lanthanides (Ln(3+)) that are Rare Earth Elements, until recently thought to be biologically inert, have recently emerged as essential metals for activity and expression of a special type of methanol dehydrogenase, XoxF. As XoxF enzyme homologs are encoded in a wide variety of microbes, including microbes active in important environmental processes such as methane and methanol metabolism, Ln(3+) may represent some of the key biogeochemical drivers in cycling of carbon and other elements. However, significant gaps in understanding the role of Ln(3+) in biological systems remain as the functions of most of the proteins potentially dependent of Ln(3+) and their roles in specific metabolic networks/respective biogeochemical cycles remain unknown. Moreover, enzymes dependent on Ln(3+) but not related to XoxF enzymes may exist, and these so far have not been recognized. Through connecting the recently uncovered genetic divergence and phylogenetic distribution of XoxF-like enzymes and through elucidation of their activities, metal and substrate specificities, along with the biological contexts of respective biochemical pathways, most parsimonious scenarios for their evolution could be uncovered. Generation of such data will firmly establish the role of Ln(3+) in the biochemistry of Life inhabiting this planet. PMID:27357406

  9. 46 CFR 180.71 - Life jackets.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Life jackets. 180.71 Section 180.71 Shipping COAST GUARD... EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.71 Life jackets. (a) An adult life jacket... life jackets equal to at least 10% of the number of persons permitted on board must be provided,...

  10. 46 CFR 180.71 - Life jackets.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Life jackets. 180.71 Section 180.71 Shipping COAST GUARD... EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.71 Life jackets. (a) An adult life jacket... life jackets equal to at least 10% of the number of persons permitted on board must be provided,...

  11. 46 CFR 180.71 - Life jackets.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Life jackets. 180.71 Section 180.71 Shipping COAST GUARD... EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.71 Life jackets. (a) An adult life jacket... life jackets equal to at least 10% of the number of persons permitted on board must be provided,...

  12. Identifying, studying and making good use of macromolecular crystals

    SciTech Connect

    Calero, Guillermo; Cohen, Aina E.; Luft, Joseph R.; Newman, Janet; Snell, Edward H.

    2014-07-25

    As technology advances, the crystal volume that can be used to collect useful X-ray diffraction data decreases. The technologies available to detect and study growing crystals beyond the optical resolution limit and methods to successfully place the crystal into the X-ray beam are discussed. Structural biology has contributed tremendous knowledge to the understanding of life on the molecular scale. The Protein Data Bank, a depository of this structural knowledge, currently contains over 100 000 protein structures, with the majority stemming from X-ray crystallography. As the name might suggest, crystallography requires crystals. As detectors become more sensitive and X-ray sources more intense, the notion of a crystal is gradually changing from one large enough to embellish expensive jewellery to objects that have external dimensions of the order of the wavelength of visible light. Identifying these crystals is a prerequisite to their study. This paper discusses developments in identifying these crystals during crystallization screening and distinguishing them from other potential outcomes. The practical aspects of ensuring that once a crystal is identified it can then be positioned in the X-ray beam for data collection are also addressed.

  13. Vector of Trypanosoma copemani identified as Ixodes sp.

    PubMed

    Austen, J M; Ryan, U M; Friend, J A; Ditcham, W G F; Reid, S A

    2011-06-01

    A total of 41 ticks were collected from 15 quokkas on Bald Island and 2 ticks from a Gilbert's potoroo from Two Peoples Bay. Three species of Ixodid ticks Ixodes australiensis, Ixodes hirsti and Ixodes myrmecobii were identified on the quokkas known to have a high prevalence of Trypanosoma copemani. Tick faeces from ticks isolated from 8 individual quokkas and a Gilbert's potoroo were examined with one identified as positive for trypanosomes. Faecal examination revealed trypanosomes similar to in vitro life-cycle stages of T. copemani. In total 12 ticks were dissected and trypanosomes found in sections of their midgut and haemolymph, 49 and 117 days after collection. Tick faeces, salivary glands and midguts from I. australiensis were screened using an 18S rRNA PCR with amplification seen only from the midguts. Sequencing showed 100% homology to T. copemani (genotype A) and 99.9% homology to the wombat (AII) isolate of T. copemani. Trypanosomes were only detected in I. australiensis as neither I. hirsti nor I. myrmecobii survived the initial 30-day storage conditions. We therefore identify a vector for T. copemani as I. australiensis and, given the detection of trypanosomes in the faeces, suggest that transmission is via the faecal-oral route. PMID:21518469

  14. Defining Life: Synthesis and Conclusions

    NASA Astrophysics Data System (ADS)

    Gayon, Jean

    2010-04-01

    The first part of the paper offers philosophical landmarks on the general issue of defining life. §1 defends that the recognition of “life” has always been and remains primarily an intuitive process, for the scientist as for the layperson. However we should not expect, then, to be able to draw a definition from this original experience, because our cognitive apparatus has not been primarily designed for this. §2 is about definitions in general. Two kinds of definition should be carefully distinguished: lexical definitions (based upon current uses of a word), and stipulative or legislative definitions, which deliberately assign a meaning to a word, for the purpose of clarifying scientific or philosophical arguments. The present volume provides examples of these two kinds of definitions. §3 examines three traditional philosophical definitions of life, all of which have been elaborated prior to the emergence of biology as a specific scientific discipline: life as animation (Aristotle), life as mechanism, and life as organization (Kant). All three concepts constitute a common heritage that structures in depth a good deal of our cultural intuitions and vocabulary any time we try to think about “life”. The present volume offers examples of these three concepts in contemporary scientific discourse. The second part of the paper proposes a synthesis of the major debates developed in this volume. Three major questions have been discussed. A first issue (§4) is whether we should define life or not, and why. Most authors are skeptical about the possibility of defining life in a strong way, although all admit that criteria are useful in contexts such as exobiology, artificial life and the origins of life. §5 examines the possible kinds of definitions of life presented in the volume. Those authors who have explicitly defended that a definition of life is needed, can be classified into two categories. The first category (or standard view) refers to two conditions

  15. Persistent Identifiers in Earth science data management environments

    NASA Astrophysics Data System (ADS)

    Weigel, Tobias; Stockhause, Martina; Lautenschlager, Michael

    2014-05-01

    Globally resolvable Persistent Identifiers (PIDs) that carry additional context information (which can be any form of metadata) are increasingly used by data management infrastructures for fundamental tasks. The notion of a Persistent Identifier is originally an abstract concept that aims to provide identifiers that are quality-controlled and maintained beyond the life time of the original issuer, for example through the use of redirection mechanisms. Popular implementations of the PID concept are for example the Handle System and the DOI System based on it. These systems also move beyond the simple identification concept by providing facilities that can hold additional context information. Not only in the Earth sciences, data managers are increasingly attracted to PIDs because of the opportunities these facilities provide; however, long-term viable principles and mechanisms for efficient organization of PIDs and context information are not yet available or well established. In this respect, promising techniques are to type the information that is associated with PIDs and to construct actionable collections of PIDs. There are two main drivers for extended PID usage: Earth science data management middleware use cases and applications geared towards scientific end-users. Motivating scenarios from data management include hierarchical data and metadata management, consistent data tracking and improvements in the accountability of processes. If PIDs are consistently assigned to data objects, context information can be carried over to subsequent data life cycle stages much easier. This can also ease data migration from one major curation domain to another, e.g. from early dissemination within research communities to formal publication and long-term archival stages, and it can help to document processes across technical and organizational boundaries. For scientific end users, application scenarios include for example more personalized data citation and improvements in the

  16. Identifying careless responses in survey data.

    PubMed

    Meade, Adam W; Craig, S Bartholomew

    2012-09-01

    When data are collected via anonymous Internet surveys, particularly under conditions of obligatory participation (such as with student samples), data quality can be a concern. However, little guidance exists in the published literature regarding techniques for detecting careless responses. Previously several potential approaches have been suggested for identifying careless respondents via indices computed from the data, yet almost no prior work has examined the relationships among these indicators or the types of data patterns identified by each. In 2 studies, we examined several methods for identifying careless responses, including (a) special items designed to detect careless response, (b) response consistency indices formed from responses to typical survey items, (c) multivariate outlier analysis, (d) response time, and (e) self-reported diligence. Results indicated that there are two distinct patterns of careless response (random and nonrandom) and that different indices are needed to identify these different response patterns. We also found that approximately 10%-12% of undergraduates completing a lengthy survey for course credit were identified as careless responders. In Study 2, we simulated data with known random response patterns to determine the efficacy of several indicators of careless response. We found that the nature of the data strongly influenced the efficacy of the indices to identify careless responses. Recommendations include using identified rather than anonymous responses, incorporating instructed response items before data collection, as well as computing consistency indices and multivariate outlier analysis to ensure high-quality data. PMID:22506584

  17. Discrimination of SM-identified individuals.

    PubMed

    Wright, Susan

    2006-01-01

    The belief that sadomasochism (SM) is violence or abusive behavior has resulted in harassment, physical attacks, and discrimination against SM-identified individuals. Historically, they were often opposed by self-identified feminists. One reason the women who practiced SM were targeted was the official opposition to sadomasochistic practices promulgated by the National Organization for Women (NOW). Current statistics of incidents of discrimination, harassment and physical attacks against SM-identified individuals and SM groups are compiled by the National Coalition for Sexual Freedom (NCSF). PMID:16803765

  18. Day laborers' life satisfaction: the role of familismo, spirituality, work, health, and discrimination.

    PubMed

    Ojeda, Lizette; Piña-Watson, Brandy

    2013-07-01

    Limited research exists on day laborers' mental health. This study identifies relevant factors that influence the life satisfaction of 143 predominantly undocumented Latino male day laborers. Findings demonstrated the importance of familismo, spirituality, work satisfaction, perceived health, and perceived discrimination on life satisfaction. Given the deleterious impact discrimination can have on mental health, we examined whether perceived discrimination's role on life satisfaction would be buffered by familismo, spirituality, work satisfaction, and perceived health. Among these variable, spirituality and perceived health were identified as protective factors against the role of perceived discrimination on life satisfaction. Implications for research and practice with Latino male day laborers are discussed. PMID:23875852

  19. Serpentinization and Life

    NASA Astrophysics Data System (ADS)

    Kelley; 2003/2005 Science Teams, D. S.

    2005-12-01

    The serendipitous discovery of the Lost City Hydrothermal Field at 30N on the Mid-Atlantic Ridge significantly changed our views about where and how life is sustained on our planet. Investigation of this site shows that it is like no other yet discovered, hosting carbonate chimneys that tower up to 60 m above the seafloor. The field rests on 1-2 my old crust, at a water depth of 800 m and is underlain by variably deformed and altered peridotite with lesser gabbro. An intense interdisciplinary field program in 2003 and a follow-on investigation in 2005 show that geological, biological, and chemical processes are strongly intertwined at this site. Serpentinization reactions in the subsurface produce pH 9-11, 40- 91° C fluids enriched in methane, hydrogen, and other hydrocarbons. Mixing of the high pH fluids with seawater forms nearly monomineralic towers of calcite, aragonite, and brucite. In contrast to the rich diversity of microorganisms typically found in black smoker environments, the warm, porous interiors of the chimneys are dominated by a single phylotype of organisms related to Methanosarcinales, which may be capable of both methane oxidation and production. Other microbes, including an organism related to an anaerobic methane-oxidizing phylotytpe (ANME-1) are present in moderate temperature environments such as the flanges (40° C to 70° C), where there is sustained mixing of pure vent fluids and seawater. They are also present in cool carbonate vein environments (<40° C) that cut the serpentinite bedrock. Bacterial colonies grow on the outside of diffusely venting chimneys where they form white to light grey filamentous strands several centimeters in length. Based on 16S rDNA clone libraries there is a relatively high diversity of organisms in these zones that include Eubacteria as well as Archaea. In contrast to the dense macrofaunal assemblages that typify most known high-temperature vent environments, the biomass at Lost City is much smaller. The

  20. Energy: It is life

    SciTech Connect

    Arques, P.

    1998-07-01

    The relationships that seem to exist between energy and man are presented in this paper. Habitually, social coefficients are connected to the gross domestic product; some parameters with correlations are: birth rate, infant mortality rate, death rate, literacy, etc. Along with energy these define the optimal energy consumption per capita; the author presents the correlation between these parameters and energy consumed per capita. There exists a high correlation between energy consumption per capita and gross domestic product per capita. The set of parameters considered are correlated with similar values relative to these two parameters. Using data collected on a group of the different countries of the world, a table of 165 countries and 22 variables has been drawn up. From the [Country x variable] matrix, a correlation table is calculated and a factorial analysis is applied to this matrix. The first factorial plan comprises 57% of the information contained in this table. Results from this first factorial plan are presented. These parameters are analyzed: influence of a country's latitude on its inhabitants' consumption; relationship between consumed energy and gross domestic product; women's fertility rate; birth rate per 1000 population; sex ratio; life expectancy at birth; rate of literacy; death rate; population growth rate. Finally, it is difficult to define precise criteria for: an optimal distribution of population according to age, but with a power consumed of above 300 W per capita, the population becomes younger; the birth rate per 1000 population; the total fertility rate per woman; the population growth rate. The authors determine that optimal energy is approximately between 200 W and 677 W inclusive.

  1. Life Cycle of Stars

    NASA Technical Reports Server (NTRS)

    1999-01-01

    In this stunning picture of the giant galactic nebula NGC 3603, the crisp resolution of NASA's Hubble Space Telescope captures various stages of the life cycle of stars in one single view. To the upper left of center is the evolved blue supergiant called Sher 25. The star has a unique circumstellar ring of glowing gas that is a galactic twin to the famous ring around the supernova 1987A. The grayish-bluish color of the ring and the bipolar outflows (blobs to the upper right and lower left of the star) indicates the presence of processed (chemically enriched) material. Near the center of the view is a so-called starburst cluster dominated by young, hot Wolf-Rayet stars and early O-type stars. A torrent of ionizing radiation and fast stellar winds from these massive stars has blown a large cavity around the cluster. The most spectacular evidence for the interaction of ionizing radiation with cold molecular-hydrogen cloud material are the giant gaseous pillars to the right of the cluster. These pillars are sculptured by the same physical processes as the famous pillars Hubble photographed in the M16 Eagle Nebula. Dark clouds at the upper right are so-called Bok globules, which are probably in an earlier stage of star formation. To the lower left of the cluster are two compact, tadpole-shaped emission nebulae. Similar structures were found by Hubble in Orion, and have been interpreted as gas and dust evaporation from possibly protoplanetary disks (proplyds). This true-color picture was taken on March 5, 1999 with the Wide Field Planetary Camera 2.

  2. Reducing Life-Cycle Costs.

    ERIC Educational Resources Information Center

    Roodvoets, David L.

    2003-01-01

    Presents factors to consider when determining roofing life-cycle costs, explaining that costs do not tell the whole story; discussing components that should go into the decision (cost, maintenance, energy use, and environmental costs); and concluding that important elements in reducing life-cycle costs include energy savings through increased…

  3. A "Second Life" for Educators

    ERIC Educational Resources Information Center

    Waters, John K.

    2009-01-01

    In this article, the author talks about the 3D virtual world known as Second Life and its potential as a learning platform. In the last few years, many colleges, universities, and libraries have established resources in what has become the preeminent multiuser virtual environment. Today, more than 100 Second Life "regions" are used for educational…

  4. The Meaning of Academic Life

    ERIC Educational Resources Information Center

    Hagedorn, Linda Serra

    2012-01-01

    This address reports the findings of a survey of higher education colleagues on the degree of happiness associated with personal definitions of "meaning of life" and "purpose in life." Using a unique sliding scale, the survey draws items from the Oxford Happiness Project among other sources and began with all ASHE members (N = 1,904) with a final…

  5. Custom Orthotics Changed My Life

    ERIC Educational Resources Information Center

    Holeton, Richard

    2010-01-01

    The narrator relates his life's downward spiral and miraculous rebound from severe foot problems using animated bullet points, images, charts, and graphs. "Custom Orthotics Changed My Life" is a work of presentation fiction, or slideshow fiction, in the form of a video with an original soundtrack. The music was composed by David Kettler, a…

  6. Ecology: accumulating threats to life

    SciTech Connect

    Peterson, R.W.

    1980-04-01

    The accumulating impacts of toxic materials like polychloridnated bephenyls (PCBs), acid rain, deforestation in the Amazon River Basin, and nuclear energy are examined as life-threatening actions that the public must recognize. Immediate action is needed to abandon destructive human activities and search out those life-supporting choices which will replace immediate gratification with long-range benefits. (DCK)

  7. [Andreas Vesalius--the life].

    PubMed

    De Caro, Raffaele; Goddeeris, Theodoor; Plessas, Pavlos; Biebrouck, Maurits; Steeno, Omer

    2014-01-01

    The details of Vesalius' life can be found in Charles O'Malley, Andreas Vesalius of Brussels, 1514-1564, (University of California Press, 1964) and in Stephen N Joffe, Andreas Vesalius: The Making, The Madman, and the Myth, (Persona Publishing, 2009). This session reviews the circumstances of his last voyage and his death and other aspects of his life. PMID:25181776

  8. Life Science. A Curriculum Guide.

    ERIC Educational Resources Information Center

    Spann, Margaret; Cowan, Connie

    The life science curriculum is designed to promote the development of healthy living habits. Emphasis is placed on problems of major concern in the daily life of students and on significant problems in modern society. The curriculum is designed for students enrolled in the coordinated vocational education and training for disadvantaged and…

  9. The Life Narrative at Midlife

    ERIC Educational Resources Information Center

    McAdams, Dan P.

    2014-01-01

    In a remarkably prescient chapter, Bertram Cohler (1982) reimagined the problems and the potentialities of psychological development across the life course as a distinctively human challenge in life narration. This chapter situates Cohler's original vision within the intellectual and scientific matrix of the late 1970s, wherein psychologists…

  10. Life sciences and Mars exploration

    NASA Technical Reports Server (NTRS)

    Sulzman, Frank M.; Rummel, John D.; Leveton, Lauren B.; Teeter, Ron

    1990-01-01

    The major life science considerations for Mars exploration missions are discussed. Radiation protection and countermeasures for zero gravity are discussed. Considerations of crew psychological health considerations and life support systems are addressed. Scientific opportunities presented by manned Mars missions are examined.

  11. Ethical Issues in Second Life

    ERIC Educational Resources Information Center

    Botterbusch, Hope R.; Talab, R. S.

    2009-01-01

    There are many unethical and illegal behaviors that take place in Second Life. This article offers several scenarios which represent some of these behaviors, including copyright infringement. It is hoped that the reader will understand how copyright infringement fits in with other unethical behaviors in Second Life. (Contains 20 resources.)

  12. Loss and Transcendence Life Themes.

    ERIC Educational Resources Information Center

    Weenolsen, Patricia

    Psychologists have often observed an underlying pattern or theme in the accounts that individuals give of their lives. To test a humanistic-existential approach to human development, 48 women were interviewed with the Loss and Transcendence (L/T) Life History Form. The L/T Life Theme is expressed in two ways: the expanded version includes the…

  13. Enjoyment and the Good Life.

    ERIC Educational Resources Information Center

    Estes, Cheryl; Henderson, Karla

    2003-01-01

    Presents information to update parks and recreation professionals about what recent research says in regard to enjoyment and the good life, noting what applications this research has for practitioners. The article focuses on: the good life and leisure services; happiness, subjective well-being, and intrinsic motivation; leisure, happiness, and…

  14. Second Thoughts about Second Life

    ERIC Educational Resources Information Center

    Bugeja, Michael J.

    2008-01-01

    Most people have at least secondhand knowledge about Second Life, a virtual-reality world created by Linden Lab, in which avatars (digital characters) lease "islands" for real-life purposes--to sell products, conduct classes, do research, hold conferences, and even recruit for admissions. About nine million avatars reportedly interact on this…

  15. Second Thoughts about Second Life

    ERIC Educational Resources Information Center

    Bugeja, Micheal J.

    2007-01-01

    Most people have at least secondhand knowledge about Second Life, a virtual-reality world created by Linden Lab, in which avatars (digital characters) lease "islands" for real-life purposes--to sell products, conduct classes, do research, hold conferences, and even recruit for admissions. About nine million avatars reportedly interact on this…

  16. Life Style Assessment: So What!

    ERIC Educational Resources Information Center

    Aubry, William E.

    The construct life style was used by Alfred Adler to describe the characteristic way in which individuals act and think. Followers of his theories are now collecting evidence to support or validate his contentions. The assessment of client life styles serves: (1) to make the client aware of his misconceptions, (2) as a reference point for therapy,…

  17. Learning for Life and Work

    ERIC Educational Resources Information Center

    Blakeley, Richard

    2009-01-01

    The publication of "Learning Through Life," the main report of the Inquiry into the Future for Lifelong Learning, has been welcomed across the trade union movement. It offers a useful and useable framework for discussing the learning needs of people through the different stages of life and makes compelling suggestions about how to adjust…

  18. The Quality of Working Life.

    ERIC Educational Resources Information Center

    Burke, Ronald J.

    1979-01-01

    Defines the concept "quality of working life," why interest in this has increased, and why guidance counselors and students should understand it. Quality of working life means more than job satisfaction or flexible working hours. It helps guidance teachers understand attitudes and expectations of students embarking on their first job. (Author/BEF)

  19. The search for extraterrestrial life.

    NASA Astrophysics Data System (ADS)

    Sagan, C.

    1994-10-01

    Odds favor the existence of life elsewhere in the universe. Mars may even have once harbored it. Titan, one of Saturn's moons, is swathed in a haze of organic molecules, which may rain onto its surface. What clues would announce the presence of life on another world? If it were based on an alien biochemistry, would we recognize it?

  20. Astrobiology: Life in Extreme Environments

    ERIC Educational Resources Information Center

    Kaur, Preeti

    2011-01-01

    Astrobiology is the study of the origin, evolution and distribution of life in the universe. It seeks to answer two important scientific questions: how did we get here and are we alone in the universe? Scientists begin by studying life on Earth and its limits. The discovery of extremophiles on Earth capable of surviving extremes encourages the…