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Sample records for linac-based isocentric electron-photon

  1. Development of head docking device for linac-based radiosurgery with a Neptun 10 PC linac.

    PubMed

    Khoshbin Khoshnazar, Alireza; Bahreyni Toossi, Mohammad Taghi; Hashemian, Abdolreza; Salek, Roham

    Stereotactic radiosurgery is a method for focused irradiation of intracranial lesions. Linac-based radiosurgery is currently performed by two techniques: couch mounted and pedestal mounted. In the first technique a device is required to affix the patient's head to the couch and neoreover to translate it accurately. Structure of such a device constructed by the authors plus acceptance test performed for evaluation is described in the article. A head docking device has been designed and constructed according to geometry of linac's couch and also desired functions. The device is cornpletely made from aluminum and consists of four major components: attachment bar, lower structure with four moveing accuracy mechanical stability and isocentric accuracy were assessed in the frame of acceptance test. Translating accuracy, mechanical stability and isocentric accuracy were found to be respectively: 1 mm, 1.64 mm and 3.2 mm with accuracy of 95%. According to AAPM report no. 54, a head docking device should translate head with an accuracy of 1 mm; this recommendation has been met. Moreover, we have demonstrated that the isocentric accuracy and mechanical stability of the device are sufficient that the device on confidently be used in stereotactic treatment. PMID:17664152

  2. Electron Photon Interaction Cross Sections

    Energy Science and Technology Software Center (ESTSC)

    2014-11-01

    Version 00 The Electron Photon Interaction Cross Sections, EPICS, provides the atomic data needed to perform coupled Electron-Photon transport calculations, to produce accurate macroscopic results, such as energy deposit and dose. Atomic data is provided for elements, Z = 1 to 100, over the energy range 10 eV to 100 GeV; note that nuclear data, such as photo-nuclear, and data for compounds, are not included. All data is in a simple computer independent text formatmore » that is standard and presented to a high precision that can be easily read by computer codes written in any computer language, e.g., C, C++, and FORTRAN. EPICS includes four separate data bases that are designed to be used in combination, these include, • The Evaluated Electron Data Library (EEDL), to describe the interaction of electrons with matter. • The Evaluated Photon Data Library (EPDL), to describe the interaction of photons with matter. • The Evaluated Atomic Data Library (EADL), to describe the emission of electrons and photons back to neutrality following an ionizing event, caused by either electron or photon interactions. • The Evaluated Excitation Data Library (EXDL), to describe the excitation of atoms due to photon interaction. All of these are available in the Extended ENDL format (ENDLX) in which the evaluations were originally performed. The first three are also available in the ENDF format; as yet ENDF does not include formats to handle excitation data (EXDL).« less

  3. Electron Photon Interaction Cross Sections

    SciTech Connect

    Cullen, D. E.

    2014-11-01

    Version 00 The Electron Photon Interaction Cross Sections, EPICS, provides the atomic data needed to perform coupled Electron-Photon transport calculations, to produce accurate macroscopic results, such as energy deposit and dose. Atomic data is provided for elements, Z = 1 to 100, over the energy range 10 eV to 100 GeV; note that nuclear data, such as photo-nuclear, and data for compounds, are not included. All data is in a simple computer independent text format that is standard and presented to a high precision that can be easily read by computer codes written in any computer language, e.g., C, C++, and FORTRAN. EPICS includes four separate data bases that are designed to be used in combination, these include, • The Evaluated Electron Data Library (EEDL), to describe the interaction of electrons with matter. • The Evaluated Photon Data Library (EPDL), to describe the interaction of photons with matter. • The Evaluated Atomic Data Library (EADL), to describe the emission of electrons and photons back to neutrality following an ionizing event, caused by either electron or photon interactions. • The Evaluated Excitation Data Library (EXDL), to describe the excitation of atoms due to photon interaction. All of these are available in the Extended ENDL format (ENDLX) in which the evaluations were originally performed. The first three are also available in the ENDF format; as yet ENDF does not include formats to handle excitation data (EXDL).

  4. Planning and delivery comparison of six linac-based stereotactic radiosurgery techniques

    NASA Astrophysics Data System (ADS)

    Thakur, Varun Singh

    This work presents planning and delivery comparison of linac-based SRS treatment techniques currently available for single lesion cranial SRS. In total, two dedicated SRS systems (Novalis Tx, Cyberknife) and a HI-ART TomoTherapy system with six different delivery techniques are evaluated. Four delivery techniques are evaluated on a Novalis Tx system: circular cones, dynamic conformal arcs (DCA), static non-coplanar intensity modulated radiotherapy (NCP-IMRT), and volumetric modulated arc therapy (RapidArc) techniques are compared with intensity modulation based helical Tomotherapy on the HI-ART Tomotherapy system and with non-isocentric, multiple overlapping based robotic radiosurgery using the CyberKnife system. Thirteen patients are retrospectively selected for the study. The target volumes of each patient are transferred to a CT scan of a Lucy phantom (Standard Imaging Inc., Middleton, WI, USA) designed for end-to-end SRS QA. In order to evaluate the plans, several indices scoring the conformality, homogeneity and gradients in the plan are calculated and compared for each of the plans. Finally, to check the clinical deliverability of the plans and the delivery accuracy of different systems, a few targets are delivered on each system. A comparison between planned dose on treatment planning system and dose delivered on Gafchromic EBT film (ISP, Wayne, New Jersey, USA) is carried out by comparing dose beam profiles, isodose lines and by calculating gamma index.

  5. Poster — Thur Eve — 65: A dosimetric comparison of isocentric and non-isocentric coplanar SBRT VMAT plans for peripheral lung tumours

    SciTech Connect

    Conroy, L; Liu, HW; Lau, H; Smith, WL

    2014-08-15

    Volumetric modulated arc therapy (VMAT) delivers lung sterotactic body radiotherapy (SBRT) in shorter treatment time and less monitor units with comparable coverage and organ at risk sparing compared to conventional SBRT treatments. Isocentric VMAT treatment of peripheral lung tumours occasionally requires couch shifts that can inhibit 360° gantry rotation, resulting in additional imaging shifts for each treatment session, and increased potential for involuntary in-fraction motion. Here, we investigate whether non-isocentric VMAT plans can achieve comparable plan quality to isocentric plans for peripheral lung tumours. Three patient plans were selected with targets displaced > 8.5 cm (range: 8.8 – 9.9 cm) laterally from patient midline. For each patient, a plan with isocentre placed within the target volume (isocentric plan) was created and optimized. The same optimization parameters were then used to create a plan with the isocentre at patient midline (non-isocentric plan). Plan quality was evaluated and compared based on planning target volume (PTV) coverage, high dose spillage, dose homogeneity, intermediate dose spillage, dose fall-off gradient, and organ at risk contraints. Non-isocentric plans of equivalent plan quality to isocentric plans were achieved for all patients by optimizing collimator rotations. Field isocentres can be placed at patient midline, as opposed to inside the target volume, with no significant degradation in VMAT plan quality for lateral tumour displacements up to 10 cm. Non-isocentric treatment of peripheral lung tumours could result in decreased overall treatment session time and eliminate the need for imaging shifts prior to VMAT treatment.

  6. Coupled electron-photon radiation transport

    SciTech Connect

    Lorence, L.; Kensek, R.P.; Valdez, G.D.; Drumm, C.R.; Fan, W.C.; Powell, J.L.

    2000-01-17

    Massively-parallel computers allow detailed 3D radiation transport simulations to be performed to analyze the response of complex systems to radiation. This has been recently been demonstrated with the coupled electron-photon Monte Carlo code, ITS. To enable such calculations, the combinatorial geometry capability of ITS was improved. For greater geometrical flexibility, a version of ITS is under development that can track particles in CAD geometries. Deterministic radiation transport codes that utilize an unstructured spatial mesh are also being devised. For electron transport, the authors are investigating second-order forms of the transport equations which, when discretized, yield symmetric positive definite matrices. A novel parallelization strategy, simultaneously solving for spatial and angular unknowns, has been applied to the even- and odd-parity forms of the transport equation on a 2D unstructured spatial mesh. Another second-order form, the self-adjoint angular flux transport equation, also shows promise for electron transport.

  7. Extended-Field Isocentric Irradiation for Hodgkin's Disease

    PubMed Central

    Kumar, P. Pradeep; Good, Roger R.; Jones, Ernest O.; Somers, James E.; McAnulty, Bruce E.; McCaul, Gayle F.; Rogers, Sally S.; Reeves, Michael A.; Sanders, Cheryl K.

    1987-01-01

    Extended-field therapeutic irradiation is the treatment of choice for the majority of patients diagnosed with pathologic stages I and II Hodgkin's disease, and total nodal irradiation can be effectively used to treat selected stage III Hodgkin's patients. Standard 100-cm source-to-axis distance extended-field isocentric technique and results are presented. ImagesFigure 1Figure 2Figure 3Figure 4Figure 5Figure 6Figure 7 PMID:3312619

  8. THz Hot-Electron Photon Counter

    NASA Technical Reports Server (NTRS)

    Karasik, Boris S.; Sergeev, Andrei V.

    2004-01-01

    We present a concept for the hot-electron transition-edge sensor capable of counting THz photons. The main need for such a sensor is a spectroscopy on future space telescopes where a background limited NEP approx. 10(exp -20) W/H(exp 1/2) is expected at around 1 THz. Under these conditions, the rate of photon arrival is very low and any currently imaginable detector with sufficient sensitivity will operate in the photon counting mode. The Hot-Electron Photon Counter based on a submicron-size Ti bridge has a very low heat capacity which provides a high enough energy resolution (approx.140 GHz) at 0.3 K. With the sensor time constant of a few microseconds, the dynamic range would be approx. 30 dB. The sensor couples to radiation via a planar antenna and is read by a SQUID amplifier or by a 1-bit RSFQ ADC. A compact array of the antenna-coupled counters can be fabricated on a silicon wafer without membranes.

  9. Linac based photofission inspection system employing novel detection concepts

    NASA Astrophysics Data System (ADS)

    Stevenson, John; Gozani, Tsahi; Elsalim, Mashal; Condron, Cathie; Brown, Craig

    2011-10-01

    Rapiscan Systems is developing a LINAC based cargo inspection system for detection of special nuclear material (SNM) in cargo containers. The system, called Photofission Based Alarm Resolution (PBAR) is being developed under a DHD/DNDO Advanced Technology Demonstration (ATD) program. The PBAR system is based on the Rapiscan Eagle P9000 X-ray system, which is a portal system with a commercial 9 MeV LINAC X-ray source. For the purposes of the DNDO ATD program, a conveyor system was installed in the portal to allow scanning and precise positioning of 20 ft ISO cargo containers. The system uses a two step inspection process. In the first step, the basic scan, the container is quickly and completely inspected using two independent radiography arrays: the conventional primary array with high spatial resolution and a lower resolution spectroscopic array employing the novel Z-Spec method. The primary array uses cadmium tungstate (CdWO 4) detectors with conventional current mode readouts using photodiodes. The Z-Spec array uses small plastic scintillators capable of performing very fast (up to 10 8 cps) gamma-ray spectroscopy. The two radiography arrays are used to locate high-Z objects in the image such as lead, tungsten, uranium, which could be potential shielding materials as well as SNM itself. In the current system, the Z-Spec works by measuring the energy spectrum of transmitted X-rays. For high-Z materials the higher end of the energy spectrum is more attenuated than for low-Z materials and thus has a lower mean energy and a narrower width than low- and medium-Z materials. The second step in the inspection process is the direct scan or alarm clearing scan. In this step, areas of the container image, which were identified as high Z, are re-inspected. This is done by precisely repositioning the container to the location of the high-Z object and performing a stationary irradiation of the area with X-ray beam. Since there are a large number of photons in the 9 MV

  10. Quality improvement process to assess tattoo alignment, set-up accuracy and isocentre reproducibility in pelvic radiotherapy patients

    PubMed Central

    Elsner, Kelly; Francis, Kate; Hruby, George; Roderick, Stephanie

    2014-01-01

    Introduction This quality improvement study tested three methods of tattoo alignment and isocentre definition to investigate if aligning lateral tattoos to minimise pitch, roll and yaw decreased set-up error, and if defining the isocentre using the lateral tattoos for cranio-caudal (CC) position improved isocentre reproducibility. The study population was patients receiving curative external beam radiotherapy (EBRT) for prostate cancer. The results are applicable to all supine pelvic EBRT patients. Methods The three sequential cohorts recruited 11, 11 and 10 patients respectively. A data set of 20 orthogonal pairs of electronic portal images (EPI) was acquired for each patient. EPIs were matched offline to digitally reconstructed radiographs. In cohort 1, lateral tattoos were adjusted to minimise roll. The anterior tattoo was used to define the isocentre. In cohort 2, lateral tattoos were aligned to minimise roll and yaw. Isocentre was defined as per cohort 1. In cohort 3, lateral tattoos were aligned as per cohort 2 and the anterior tattoo was adjusted to minimise pitch. Isocentre was defined by the lateral tattoos for CC position and the anterior tattoo for the left–right position. Results Cohort 3 results were superior as CC systematic and random set-up errors reduced from −1.3 mm to −0.5 mm, and 3.1 mm to 1.4 mm respectively, from cohort 1 to cohort 3. Isocentre reproducibility also improved from 86.7% to 92.1% of treatment isocentres within 5 mm of the planned isocentre. Conclusion The methods of tattoo alignment and isocentre definition in cohort 3 reduced set-up errors and improved isocentre reproducibility. PMID:25598978

  11. Anterior-posterior treatment localization in pelvic radiotherapy: tattoos or fixed couch-to-isocentre distance.

    PubMed

    Greer, P B; Mortensen, T M

    1997-01-01

    The methods of determining the anterior-posterior isocentre location in pelvic radiotherapy are either by aligning lateral localization lasers to tattoo marks on skin, or by setting a constant daily couch-to-isocentre distance. While using the former method the day-to-day vertical couch movement was recorded and combined with measurements of day-to-day anterior-posterior patient movement made with an electronic portal imaging device to determine whether couch vertical movement contributes to anterior-posterior setup variation. Seven unimmobilized patients were studied, four supine prostate and three prone rectum patients. The two motions were found to be highly correlated (correlation coefficient = 0.82) which supports the constant couch-to-isocentre distance approach. When the day-to-day couch vertical movement was subtracted from the anterior-posterior movement results the setup variation was reduced in six of the seven patients. PMID:9136107

  12. Multidimensional electron-photon transport with standard discrete ordinates codes

    SciTech Connect

    Drumm, C.R.

    1995-12-31

    A method is described for generating electron cross sections that are compatible with standard discrete ordinates codes without modification. There are many advantages of using an established discrete ordinates solver, e.g. immediately available adjoint capability. Coupled electron-photon transport capability is needed for many applications, including the modeling of the response of electronics components to space and man-made radiation environments. The cross sections have been successfully used in the DORT, TWODANT and TORT discrete ordinates codes. The cross sections are shown to provide accurate and efficient solutions to certain multidimensional electronphoton transport problems.

  13. Electronic/photonic interfaces for ultrafast data processing.

    SciTech Connect

    Overberg, Mark E.; Geib, Kent Martin; Serkland, Darwin Keith; Hsu, Alan Yuan-Chun; Keeler, Gordon Arthur; Finnegan, Patrick Sean

    2008-09-01

    This report summarizes a 3-month program that explored the potential areas of impact for electronic/photonic integration technologies, as applied to next-generation data processing systems operating within 100+ Gb/s optical networks. The study included a technology review that targeted three key functions of data processing systems, namely receive/demultiplexing/clock recovery, data processing, and transmit/multiplexing. Various technical approaches were described and evaluated. In addition, we initiated the development of high-speed photodetectors and hybrid integration processes, two key elements of an ultrafast data processor. Relevant experimental results are described herein.

  14. An Electron/Photon/Relaxation Data Library for MCNP6

    SciTech Connect

    Hughes, III, H. Grady

    2015-08-07

    The capabilities of the MCNP6 Monte Carlo code in simulation of electron transport, photon transport, and atomic relaxation have recently been significantly expanded. The enhancements include not only the extension of existing data and methods to lower energies, but also the introduction of new categories of data and methods. Support of these new capabilities has required major additions to and redesign of the associated data tables. In this paper we present the first complete documentation of the contents and format of the new electron-photon-relaxation data library now available with the initial production release of MCNP6.

  15. On isocentre adjustment and quality control in linear accelerator based radiosurgery with circular collimators and room lasers

    NASA Astrophysics Data System (ADS)

    Treuer, H.; Hoevels, M.; Luyken, K.; Gierich, A.; Kocher, M.; Müller, R.-P.; Sturm, V.

    2000-08-01

    We have developed a densitometric method for measuring the isocentric accuracy and the accuracy of marking the isocentre position for linear accelerator based radiosurgery with circular collimators and room lasers. Isocentric shots are used to determine the accuracy of marking the isocentre position with room lasers and star shots are used to determine the wobble of the gantry and table rotation movement, the effect of gantry sag, the stereotactic collimator alignment, and the minimal distance between gantry and table rotation axes. Since the method is based on densitometric measurements, beam spot stability is implicitly tested. The method developed is also suitable for quality assurance and has proved to be useful in optimizing isocentric accuracy. The method is simple to perform and only requires a film box and film scanner for instrumentation. Thus, the method has the potential to become widely available and may therefore be useful in standardizing the description of linear accelerator based radiosurgical systems.

  16. Electron photon verification calculations using MCNP4B

    SciTech Connect

    Gierga, D.P.; Adams, K.J.

    1998-07-01

    MCNP4B was released in February 1997 with significant enhancements to electron/photon transport methods. These enhancements have been verified against a wide range of published electron/photon experiments, spanning high energy bremsstrahlung production to electron transmission and reflection. Three sets of bremsstrahlung experiments were simulated. The first verification calculations for bremsstrahlung production used the experimental results in Faddegon for 15 MeV electrons incident on lead, aluminum, and beryllium targets. The calculated integrated bremsstrahlung yields, the bremsstrahlung energy spectra, and the mean energy of the bremsstrahlung beam were compared with experiment. The impact of several MCNP tally options and physics parameters was explored in detail. The second was the experiment of O`Dell which measured the bremsstrahlung spectra from 10 and 20.9 MeV electrons incident on a gold/tungsten target. The final set was a comparison of relative experimental spectra with calculated results for 9.66 MeV electrons incident on tungsten based on the experiment of Starfelt and Koch. The transmission experiments of Ebert were also studied, including comparisons of transmission coefficients for 10.2 MeV electrons incident on carbon, silver, and uranium foils. The agreement between experiment and simulation was usually within two standard deviations of the experimental and calculational errors.

  17. Multidimensional electron-photon transport with standard discrete ordinates codes

    SciTech Connect

    Drumm, C.R.

    1997-04-01

    A method is described for generating electron cross sections that are comparable with standard discrete ordinates codes without modification. There are many advantages of using an established discrete ordinates solver, e.g. immediately available adjoint capability. Coupled electron-photon transport capability is needed for many applications, including the modeling of the response of electronics components to space and man-made radiation environments. The cross sections have been successfully used in the DORT, TWODANT and TORT discrete ordinates codes. The cross sections are shown to provide accurate and efficient solutions to certain multidimensional electron-photon transport problems. The key to the method is a simultaneous solution of the continuous-slowing-down (CSD) portion and elastic-scattering portion of the scattering source by the Goudsmit-Saunderson theory. The resulting multigroup-Legendre cross sections are much smaller than the true scattering cross sections that they represent. Under certain conditions, the cross sections are guaranteed positive and converge with a low-order Legendre expansion.

  18. Radial Moment Calculations of Coupled Electron-Photon Beams

    SciTech Connect

    FRANKE,BRIAN C.; LARSEN,EDWARD W.

    2000-07-19

    The authors consider the steady-state transport of normally incident pencil beams of radiation in slabs of material. A method has been developed for determining the exact radial moments of 3-D beams of radiation as a function of depth into the slab, by solving systems of 1-D transport equations. They implement these radial moment equations in the ONEBFP discrete ordinates code and simulate energy-dependent, coupled electron-photon beams using CEPXS-generated cross sections. Modified P{sub N} synthetic acceleration is employed to speed up the iterative convergence of the 1-D charged particle calculations. For high-energy photon beams, a hybrid Monte Carlo/discrete ordinates method is examined. They demonstrate the efficiency of the calculations and make comparisons with 3-D Monte Carlo calculations. Thus, by solving 1-D transport equations, they obtain realistic multidimensional information concerning the broadening of electron-photon beams. This information is relevant to fields such as industrial radiography, medical imaging, radiation oncology, particle accelerators, and lasers.

  19. Induction-linac based free-electron laser amplifiers for plasma heating

    SciTech Connect

    Jong, R.A.

    1988-08-22

    We describe an induction-linac based free-electron laser amplifier that is presently under construction at the Lawrence Livermore National Laboratory. It is designed to produce up to 2 MW of average power at a frequency of 250 GHz for plasma heating experiments in the Microwave Tokamak Experiment. In addition, we shall describe a FEL amplifier design for plasma heating of advanced tokamak fusion devices. This system is designed to produce average power levels of about 10 MW at frequencies ranging form 280 to 560 GHz. 7 refs., 1 tab.

  20. Hot-Electron Photon Counters for Detecting Terahertz Photons

    NASA Technical Reports Server (NTRS)

    Karasik, Boris; Sergeyev, Andrei

    2005-01-01

    A document proposes the development of hot-electron photon counters (HEPCs) for detecting terahertz photons in spaceborne far-infrared astronomical instruments. These would be superconducting- transition-edge devices: they would contain superconducting bridges that would have such low heat capacities that single terahertz photons would cause transient increases in their electron temperatures through the superconducting- transition range, thereby yielding measurable increases in electrical resistance. Single devices or imaging arrays of the devices would be fabricated as submicron-sized bridges made from films of disordered Ti (which has a superconducting- transition temperature of .0.35 K) between Nb contacts on bulk silicon or sapphire substrates. In operation, these devices would be cooled to a temperature of .0.3 K. The proposed devices would cost less to fabricate and operate, relative to integrating bolometers of equal sensitivity, which must be operated at a temperature of approx. = 0.1 K.

  1. Dosimetric comparison of helical tomothearpy and linac-based IMRT in whole abdomen radiotherapy

    NASA Astrophysics Data System (ADS)

    Kang, Young-nam; Kim, Dae-Hyun; Jang, Hong Seok; Song, Jin Ho; Choi, Byung Ock; Cho, Seok Goo; Jung, Ji-Young; Kay, Chul Seung

    2012-10-01

    Recent advances in radiotherapy techniques have allowed a significant improvement in the therapeutic ratio of whole abdominal irradiation (WAI) through linear-accelerator (Linac) based intensity-modulated radiotherapy (IMRT) and helical tomotherapy (HT). IMRT has been shown to reduce the dose to organs at risk (OAR) while adequately treating the tumor volume. HT operates by adjusting 51 beam directions, couch speed, pitch and shapes of a binary multileaf collimator (MLC), with the purpose of clinically increasing the befit to the patient. We incorporated helical tomotherapy as a new modality for WAI for the treatment of non-Hodgkin's lymphoma patients whose disease involved the intestine and the mesenteric lymph nodes. Excellent tumor coverage with effective sparing of normal organ sparings, and homogeneous dose distribution could be achieved. This study dosimetrically compared HT and linac-based IMRT by using several indices, including the conformity index (CI) and the homogeneity index (HI) for the planning target volume (PTV), as well as the, max dose and the mean dose and the quality index (QI) for five organs at risk (OARs). The HI and the CI were used to compare the quality of target coverage while the QI was used compare the dosimetric performans for OAR systems. The target coverages between the two systems were similar, but the most QIs were lower than 1, what means that HT is batter at sparing OARs than IMRT. Tomotherapy enabled excellent target coverage, effective sparing of normal tissues, and homogeneous dose distribution without severe acute toxicity.

  2. Update on the Innovative Carbon/Proton Non-Scaling FFAG Isocentric gantries for Cancer Therapy

    SciTech Connect

    Trbojevic, D.

    2010-05-23

    There is a dramatic increase in numbers of proton/carbon cancer therapy facilities in recent years due to a clear advantage with respect to the other radiation therapy treatments. Cost of the ion cancer therapy is still to high for most of the hospitals and a dominating part comes from the delivery systems. We had previously presented design of the carbon and proton isocentric gantries using the principle of the non-scaling alternating gradient fixed field magnets (NS-FFAG), where a size and weight of the magnets should be dramatically reduced. The weight of the transport elements of the carbon isocentric gantry is estimated to be 1.5 tons compared to the 130 tons a weight of the Heidelberg gantry. The similar claim of 500 kg comes for the transport elements of the proton permanent magnet gantry. We present an update on these designs.

  3. NOTE: A method for determining the alignment accuracy of the treatment table axis at an isocentric irradiation facility

    NASA Astrophysics Data System (ADS)

    Karger, Christian P.; Hartmann, Günther H.; Heeg, Peter; Jäkel, Oliver

    2001-01-01

    At an isocentric irradiation facility, the rotation axis of the treatment table has to be accurately aligned in vertical orientation to the isocentre, which is usually marked by three perpendicular laser planes. In particular, high precision radiotherapy techniques, such as radiosurgery or intensity modulated radiotherapy, require a higher alignment accuracy of the table axis than routinely specified by the manufacturers. A simple and efficient method is presented to measure the direction and the size of the displacement of the table axis from the isocentre as marked by the lasers. In addition, the inclination of the table axis against the vertical direction can be determined. The measured displacement and inclination provide the required data to correct for possible misalignments of the treatment table axis and to maintain its alignment. Measurements were performed over a period of two years for a treatment table located at the German heavy ion therapy facility. The mean radial distance between the table axis and the isocentre was found to be 0.25±0.25 mm. The mean inclination of the table axis in the XZ- and YZ-planes was measured to be -0.03±0.02° and -0.04±0.01°, respectively. The measurements demonstrate the good alignment of the treatment table over the analysed time period. The described method can be applied to any isocentric irradiation facility, especially including isocentric linear accelerators used for radiosurgery or other high precision irradiation techniques.

  4. Optimizing LINAC-based stereotactic radiotherapy of uveal melanomas: 7 years' clinical experience

    SciTech Connect

    Dieckmann, Karin . E-mail: Karin.Dieckmann@akhwien.at; Georg, Dietmar; Bogner, Joachim; Zehetmayer, Martin; Petersch, Bernhard; Chorvat, Martin; Weitmann, Hajo; Poetter, Richard

    2006-11-15

    Purpose: To report on the clinical outcome of LINAC-based stereotactic radiotherapy (SRT) of uveal melanomas. Additionally, a new prototype (hardware and software) for automated eye monitoring and gated SRT using a noninvasive eye fixation technique is described. Patients and Methods: Between June 1997 and March 2004, 158 patients suffering from uveal melanoma were treated at a LINAC with 6 MV (5 x 14 Gy; 5 x 12 Gy prescribed to 80% isodose) photon beams. To guarantee identical patient setup during treatment planning (CT and MRI) and treatment delivery, patients were immobilized with a BrainLAB thermoplastic mask. Eye immobilization was achieved by instructing the patient to fixate on a light source integrated into the mask system. A mini-video camera was used to provide on-line information about the eye and pupil position, respectively. A new CT and magnetic resonance (MR) compatible prototype, based on head-and-neck fixation and the infrared tracking system ExacTrac, has been developed and evaluated since 2002. This system records maximum temporal and angular deviations during treatment and, based on tolerance limits, a feedback signal to the LINAC enables gated SRT. Results: After a median follow-up of 33.4 months (range, 3-85 months), local control was achieved in 98%. Fifteen patients (9.0%) developed metastases. Secondary enucleation was performed in 23 patients (13.8%). Long-term side effects were retinopathy (n = 70; 44%), cataract (n = 30; 23%), optic neuropathy (n = 65; 41%), and secondary neovascular glaucoma (n = 23; 13.8%). Typical situations when preset deviation criteria were exceeded were slow drifts (fatigue), large sudden eye movements (irritation), or eye closing (fatigue). In these cases, radiation was reliably interrupted by the gating system. In our clinical setup, the novel system for computer-controlled gated SRT of uveal melanoma was well tolerated by about 30 of the patients treated with this system so far. Conclusion: LINAC-based SRT of

  5. A photocathode rf gun design for a mm-wave linac-based FEL

    SciTech Connect

    Nassiri, A.; Berenc, T,; Foster, J.; Waldschmidt, G.; Zhou, J.

    1995-07-01

    In recent years, advances in the rf gun technology have made it possible to produce small beam emittances suitable for short period microundulators which take advantage of the low emittance beam to reduce the wavelength of FELs. At the Advanced Photon Source, we are studying the design of a compact 50-MeV superconducting mm-wave linac-based FEL for the production of short wavelengths ({approximately}300 nm) to carry out FEL demonstration experiments. The electron source considered for the linac is a 30- GHz, 3 1/2-cell {pi}-mode photocathode rf gun. For cold model rf measurements a 15-GHz prototype structure was fabricated. Here we report on the design, numerical modelling and the initial cold-model rf measurement results on the 15-GHz prototype structure.

  6. High Repetition Rate, LINAC-Based Nuclear Resonance Fluorescence FY 2008 Final Report

    SciTech Connect

    Scott M Watson; Mathew T Kinlaw; James L Jones; Alan W. Hunt; Glen A. Warren

    2008-12-01

    This summarizes the first year of a multi-laboratory/university, multi-year effort focusing on high repetition rate, pulsed LINAC-based nuclear resonance fluorescence (NRF) measurements. Specifically, this FY2008 effort centered on experimentally assessing NRF measurements using pulsed linear electron accelerators, operated at various repetition rates, and identifying specific detection requirements to optimize such measurements. Traditionally, interest in NRF as a detection technology, which continues to receive funding from DHS and DOE/NA-22, has been driven by continuous-wave (CW), Van de Graff-based bremsstrahlung sources. However, in addition to the relatively sparse present-day use of Van de Graff sources, only limited NRF data from special nuclear materials has been presented; there is even less data available regarding shielding effects and photon source optimization for NRF measurements on selected nuclear materials.

  7. Time delay measurement for linac based treatment delivery in synchronized respiratory gating radiotherapy.

    PubMed

    Jin, Jian-Yue; Yin, Fang-Fang

    2005-05-01

    A time delay in a respiratory gating system could cause an unexpected phase mismatch for synchronized gating radiotherapy. This study presents a method of identifying and measuring the time delay in a gating system. Various port films were taken for a motion phantom at different gating window levels with a very narrow window size. The time delay for the gating system was determined by comparing the motion curve (the position of a moving object versus the gating time) measured in the port films to the motion curve determined by the video cameras. The measured time delay for a linac-based gating system was 0.17+/-0.03 s. This time delay could induce target missing if it was not properly taken into account for the synchronized gating radiotherapy. Measurement/verification of the time delay should be considered as an important part of the accepting/commissioning test before the clinical use of the gating system. PMID:15984681

  8. Proposal for a New Prognostic Score for Linac-Based Radiosurgery in Cerebral Arteriovenous Malformations

    SciTech Connect

    Milker-Zabel, Stefanie; Kopp-Schneider, Annette; Wiesbauer, Hannah; Schlegel, Wolfgang; Huber, Peter; Debus, Juergen; Zabel-du Bois, Angelika

    2012-06-01

    Purpose: We evaluate patient-, angioma-, and treatment-specific factors for successful obliteration of cerebral arteriovenous malformations (AVM) to develop a new appropriate score to predict patient outcome after linac-based radiosurgery (RS). Methods and Materials: This analysis in based on 293 patients with cerebral AVM. Mean age at treatment was 38.8 years (4-73 years). AVM classification according Spetzler-Martin was 55 patients Grade I (20.5%), 114 Grade II (42.5%), 79 Grade III (29.5%), 19 Grade IV (7.1%), and 1 Grade V (0.4%). Median maximum AVM diameter was 3.0 cm (range, 0.3-10 cm). Median dose prescribed to the 80% isodose was 18 Gy (range, 12-22 Gy). Eighty-five patients (29.1%) had prior partial embolization; 141 patients (51.9%) experienced intracranial hemorrhage before RS. Median follow-up was 4.2 years. Results: Age at treatment, maximum diameter, nidus volume, and applied dose were significant factors for successful obliteration. Under presumption of proportional hazard in the dose range between 12 and 22 Gy/80% isodose, an increase of obliteration rate of approximately 25% per Gy was seen. On the basis of multivariate analysis, a prediction score was calculated including AVM maximum diameter and age at treatment. The prediction error up to the time point 8 years was 0.173 for the Heidelberg score compared with the Kaplan-Meier value of 0.192. An increase of the score of 1 point results in a decrease of obliteration chance by a factor of 0.447. Conclusion: The proposed score is linac-based radiosurgery-specific and easy to handle to predict patient outcome. Further validation on an independent patient cohort is necessary.

  9. Beam-transport study of an isocentric rotating ion gantry with minimum number of quadrupoles

    NASA Astrophysics Data System (ADS)

    Pavlovic, Márius; Griesmayer, Erich; Seemann, Rolf

    2005-06-01

    A beam-transport study of an isocentric gantry for ion therapy is presented. The gantry is designed with the number of quadrupoles down to the theoretical minimum, which is the feature published for the first time in this paper. This feature has been achieved without compromising the ion-optical functions of the beam-transport system that is capable of handling non-symmetric beams (beams with different emittances in vertical and horizontal plane), pencil-beam scanning, double-achromatic optics and beam-size control. Ion-optical properties of the beam-transport system are described, discussed and illustrated by computer simulations performed by the TRANSPORT-code.

  10. Linac-based stereotactic radiotherapy and radiosurgery in patients with meningioma

    PubMed Central

    2014-01-01

    Background It was our purpose to analyze long-term clinical outcome and to identify prognostic factors after Linac-based fractionated stereotactic radiotherapy (Linac-based FSRT) and stereotactic radiosurgery (SRS) in patients with intracranial meningiomas. Materials and methods Between 10/1995 and 03/2009, 297 patients with a median age of 59 years were treated with FSRT for intracranial meningioma. 50 patients had a Grade I meningioma, 20 patients had a Grade II meningioma, 12 patients suffered from a Grade III tumor, and in 215 cases no histology was obtained (Grade 0). Of the 297 patients, 144 underwent FSRT as their primary treatment and 158 underwent postoperative FSRT. 179 patients received normofractionated radiotherapy (nFSRT), 92 patients received hypofractionated FSRT (hFSRT) and 26 patients underwent SRS. Patients with nFSRT received a mean total dose of 57.31 ± 5.82 Gy, patients with hFSRT received a mean total dose of 37.6 ± 4.4 Gy and patients who underwent SRS received a mean total dose of 17.31 ± 2.58 Gy. Results Median follow-up was 35 months. Overall progression free survival (PFS) was 92.3% at 3 years, 87% at 5 years and 84.1% at 10 years. Patients with adjuvant radiotherapy showed significantly better PFS-rates than patients who had been treated with primary radiotherapy. There was no significant difference between PFS-rates of nFSRT, hFSRT and SRS patients. PFS-rates were independent of tumor size. Patients who had received nFSRT showed less acute toxicity than those who had received hFSRT. In the Grade 0/I group the rate of radiologic focal reactions was significantly lower than in the atypical/malignant histology group. Conclusion This large study showed that FSRT is an effective and safe treatment modality with high PFS-rates for intracranial meningioma. We identified “pathological grading” and and “prior surgery” as significant prognostic factors. PMID:24650090

  11. Dosimetric analysis of isocentrically shielded volumetric modulated arc therapy for locally recurrent nasopharyngeal cancer

    PubMed Central

    Lu, Jia-Yang; Huang, Bao-Tian; Xing, Lei; Chang, Daniel T.; Peng, Xun; Xie, Liang-Xi; Lin, Zhi-Xiong; Li, Mei

    2016-01-01

    This study aimed to investigate the dosimetric characteristics of an isocentrically shielded RapidArc (IS-RA) technique for treatment of locally recurrent nasopharyngeal cancer (lrNPC). In IS-RA, the isocenter was placed at the center of the pre-irradiated brainstem (BS)/spinal cord (SC) and the jaws were set to shield the BS/SC while ensuring the target coverage during the whole gantry rotation. For fifteen patients, the IS-RA plans were compared with the conventional RapidArc (C-RA) regarding target coverage, organ-at-risk (OAR) sparing and monitor units (MUs). The relationship between the dose reduction of BS/SC and some geometric parameters including the angle extended by the target with respect to the axis of BS/SC (Ang_BSSC), the minimum distance between the target and BS/SC (Dist_Min) and the target volume were evaluated. The IS-RA reduced the BS/SC doses by approximately 1–4 Gy on average over the C-RA, with more MUs. The IS-RA demonstrated similar target coverage and sparing of other OARs except for slightly improved sparing of optic structures. More dose reduction in the isocentric region was observed in the cases with larger Ang_BSSC or smaller Dist_Min. Our results indicated that the IS-RA significantly improves the sparing of BS/SC without compromising dosimetric requirements of other involved structures for lrNPC. PMID:27173670

  12. Evaluation of beam delivery and ripple filter design for non-isocentric proton and carbon ion therapy

    NASA Astrophysics Data System (ADS)

    Grevillot, L.; Stock, M.; Vatnitsky, S.

    2015-10-01

    This study aims at selecting and evaluating a ripple filter design compatible with non-isocentric proton and carbon ion scanning beam treatment delivery for a compact nozzle. The use of non-isocentric treatments when the patient is shifted as close as possible towards the nozzle exit allows for a reduction in the air gap and thus an improvement in the quality of scanning proton beam treatment delivery. Reducing the air gap is less important for scanning carbon ions, but ripple filters are still necessary for scanning carbon ion beams to reduce the number of energy steps required to deliver homogeneous SOBP. The proper selection of ripple filters also allows a reduction in the possible transverse and depth-dose inhomogeneities that could appear in non-isocentric conditions in particular. A thorough review of existing ripple filter designs over the past 16 years is performed and a design for non-isocentric treatment delivery is presented. A unique ripple filter quality index (QIRiFi) independent of the particle type and energy and representative of the ratio between energy modulation and induced scattering is proposed. The Bragg peak width evaluated at the 80% dose level (BPW80) is proposed to relate the energy modulation of the delivered Bragg peaks and the energy layer step size allowing the production of homogeneous SOBP. Gate/Geant4 Monte Carlo simulations have been validated for carbon ion and ripple filter simulations based on measurements performed at CNAO and subsequently used for a detailed analysis of the proposed ripple filter design. A combination of two ripple filters in a series has been validated for non-isocentric delivery and did not show significant transverse and depth-dose inhomogeneities. Non-isocentric conditions allow a significant reduction in the spot size at the patient entrance (up to 350% and 200% for protons and carbon ions with range shifter, respectively), and therefore in the lateral penumbra in the patients.

  13. Evaluation of beam delivery and ripple filter design for non-isocentric proton and carbon ion therapy.

    PubMed

    Grevillot, L; Stock, M; Vatnitsky, S

    2015-10-21

    This study aims at selecting and evaluating a ripple filter design compatible with non-isocentric proton and carbon ion scanning beam treatment delivery for a compact nozzle. The use of non-isocentric treatments when the patient is shifted as close as possible towards the nozzle exit allows for a reduction in the air gap and thus an improvement in the quality of scanning proton beam treatment delivery. Reducing the air gap is less important for scanning carbon ions, but ripple filters are still necessary for scanning carbon ion beams to reduce the number of energy steps required to deliver homogeneous SOBP. The proper selection of ripple filters also allows a reduction in the possible transverse and depth-dose inhomogeneities that could appear in non-isocentric conditions in particular. A thorough review of existing ripple filter designs over the past 16 years is performed and a design for non-isocentric treatment delivery is presented. A unique ripple filter quality index (QIRiFi) independent of the particle type and energy and representative of the ratio between energy modulation and induced scattering is proposed. The Bragg peak width evaluated at the 80% dose level (BPW80) is proposed to relate the energy modulation of the delivered Bragg peaks and the energy layer step size allowing the production of homogeneous SOBP. Gate/Geant4 Monte Carlo simulations have been validated for carbon ion and ripple filter simulations based on measurements performed at CNAO and subsequently used for a detailed analysis of the proposed ripple filter design. A combination of two ripple filters in a series has been validated for non-isocentric delivery and did not show significant transverse and depth-dose inhomogeneities. Non-isocentric conditions allow a significant reduction in the spot size at the patient entrance (up to 350% and 200% for protons and carbon ions with range shifter, respectively), and therefore in the lateral penumbra in the patients. PMID:26418366

  14. Investigation of the accuracy of MV radiation isocentre calculations in the Elekta cone-beam CT software XVI

    NASA Astrophysics Data System (ADS)

    Riis, Hans L.; Moltke, Lars N.; Zimmermann, Sune J.; Ebert, Martin A.; Rowshanfarzad, Pejman

    2016-06-01

    Accurate determination of the megavoltage (MV) radiation isocentre of a linear accelerator (linac) is an important task in radiotherapy. The localization of the MV radiation isocentre is crucial for correct calibration of the in-room lasers and the cone-beam CT scanner used for patient positioning prior to treatment. Linac manufacturers offer tools for MV radiation isocentre localization. As a user, there is no access to the documentation for the underlying method and calculation algorithm used in the commercial software. The idea of this work was to evaluate the accuracy of the software tool for MV radiation isocentre calculation as delivered by Elekta using independent software. The image acquisition was based on the scheme designed by the manufacturer. Eight MV images were acquired in each series of a ball-bearing (BB) phantom attached to the treatment couch. The images were recorded at cardinal angles of the gantry using the electronic portal imaging device (EPID). Eight Elekta linacs with three different types of multileaf collimators (MLCs) were included in the test. The influence of MLC orientation, x-ray energy, and phantom modifications were examined. The acquired images were analysed using the Elekta x-ray volume imaging (XVI) software and in-house developed (IHD) MATLAB code. Results from the two different software were compared. A discrepancy in the longitudinal direction of the isocentre localization was found averaging 0.23 mm up to a maximum of 0.75 mm. The MLC orientation or the phantom asymmetry in the longitudinal direction do not appear to cause the discrepancy. The main cause of the differences could not be clearly identified. However, it is our opinion that the commercial software delivered by the linac manufacturer should be improved to reach better stability and precise results in the MV radiation isocentre calculations.

  15. Investigation of the accuracy of MV radiation isocentre calculations in the Elekta cone-beam CT software XVI.

    PubMed

    Riis, Hans L; Moltke, Lars N; Zimmermann, Sune J; Ebert, Martin A; Rowshanfarzad, Pejman

    2016-06-01

    Accurate determination of the megavoltage (MV) radiation isocentre of a linear accelerator (linac) is an important task in radiotherapy. The localization of the MV radiation isocentre is crucial for correct calibration of the in-room lasers and the cone-beam CT scanner used for patient positioning prior to treatment. Linac manufacturers offer tools for MV radiation isocentre localization. As a user, there is no access to the documentation for the underlying method and calculation algorithm used in the commercial software. The idea of this work was to evaluate the accuracy of the software tool for MV radiation isocentre calculation as delivered by Elekta using independent software. The image acquisition was based on the scheme designed by the manufacturer. Eight MV images were acquired in each series of a ball-bearing (BB) phantom attached to the treatment couch. The images were recorded at cardinal angles of the gantry using the electronic portal imaging device (EPID). Eight Elekta linacs with three different types of multileaf collimators (MLCs) were included in the test. The influence of MLC orientation, x-ray energy, and phantom modifications were examined. The acquired images were analysed using the Elekta x-ray volume imaging (XVI) software and in-house developed (IHD) MATLAB code. Results from the two different software were compared. A discrepancy in the longitudinal direction of the isocentre localization was found averaging 0.23 mm up to a maximum of 0.75 mm. The MLC orientation or the phantom asymmetry in the longitudinal direction do not appear to cause the discrepancy. The main cause of the differences could not be clearly identified. However, it is our opinion that the commercial software delivered by the linac manufacturer should be improved to reach better stability and precise results in the MV radiation isocentre calculations. PMID:27183466

  16. Analytical bunch compression studies for a linac-based electron accelerator

    NASA Astrophysics Data System (ADS)

    Schreck, M.; Wesolowski, P.

    2015-10-01

    The current paper deals with analytical bunch compression studies for FLUTE whose results are compared to simulations. FLUTE is a linac-based electron accelerator with a design energy of approximately 40 MeV currently being constructed at the Karlsruhe Institute of Technology. One of the goals of FLUTE is to generate electron bunches with their length lying in the femtosecond regime. In the first phase this will be accomplished using a magnetic bunch compressor. This compressor forms the subject of the studies presented. The paper is divided into two parts. The first part deals with pure geometric investigations of the bunch compressor where space charge effects and the backreaction of bunches with coherent synchrotron radiation are neglected. The second part is dedicated to the treatment of space charge effects. The upshot is that the analytical results in the two parts agree quite well with what is obtained from simulations. This paper shall form the basis for future analytical studies of the FLUTE bunch compressor and of bunch compression, in general.

  17. Modeling of induction-linac based free-electron laser amplifiers

    SciTech Connect

    Jong, R.A.; Fawley, W.M.; Scharlemann, E.T.

    1988-12-01

    We describe the modeling of an induction-linac based free-electron laser (IFEL) amplifier for producing multimegawatt levels of microwave power. We have used the Lawrence Livermore National Laboratory (LLNL) free-electron laser simulation code, FRED, and the simulation code for sideband calculations, GINGER for this study. For IFEL amplifiers in the frequency range of interest (200 to 600 GHz), we have devised a wiggler design strategy which incorporates a tapering algorithm that is suitable for free-electron laser (FEL) systems with moderate space-charge effects and that minimizes spontaneous noise growth at frequencies below the fundamental, while enhancing the growth of the signal at the fundamental. In addition, engineering design considerations of the waveguide wall loading and electron beam fill factor in the waveguide set limits on the waveguide dimensions, the wiggler magnet gap spacing, the wiggler period, and the minimum magnetic field strength in the tapered region of the wiggler. As an example, we shall describe an FEL amplifier designed to produce an average power of about 10 MW at a frequency of 280 GHz to be used for electron cyclotron resonance heating of tokamak fusion devices. 17 refs., 4 figs.

  18. Modeling of induction-linac based free-electron laser amplifiers

    NASA Astrophysics Data System (ADS)

    Jong, R. A.; Fawley, W. M.; Scharlemann, E. T.

    1988-12-01

    We describe the modeling of an induction-linac based free-electron laser (IFEL) amplifier for producing multimegawatt levels of microwave power. We have used the Lawrence Livermore National Laboratory (LLNL) free-electron laser simulation code, FRED, and the simulation code for sideband calculations, GINGER for this study. For IFEL amplifiers in the frequency range of interest (200 to 600 GHz), we have devised a wiggler design strategy which incorporates a tapering algorithm that is suitable for Free-Electron Laser (FEL) systems with moderate space-charge effects and that minimizes spontaneous noise growth at frequencies below the fundamental, while enhancing the growth of the signal at the fundamental. In addition, engineering design considerations of the waveguide wall loading and electron beam fill factor in the waveguide set limits on the waveguide dimensions, the wiggler magnet gap spacing, the wiggler period, and the minimum magnetic field strength in the tapered region of the wiggler. As an example, we shall describe an FEL amplifier designed to produce an average power of about 10 MW at a frequency of 280 GHz to be used for electron cyclotron resonance heating of tokamak fusion devices.

  19. Modeling Of Induction-Linac Based Free-Electron Laser Amplifiers

    NASA Astrophysics Data System (ADS)

    Jong, Raynard A.; Fawley, William M.; Scharlemann, Ernst T.

    1989-05-01

    We describe the modeling of an induction-linac based free-electron laser (IFEL) amplifier for producing multi-megawatt levels of microwave power. We have used the Lawrence Livermore National Laboratory (LLNL) free-electron laser simulation code, FRED, and the simulation code for sideband calculations, GINGER for this study. For IFEL amplifiers in the frequency range of interest (200 to 600 GHz), we have devised a wiggler design strategy which incorporates a tapering algorithm that is suitable for free-electron laser (FEL) systems with moderate space-charge effects and that minimizes spontaneous noise growth at frequencies below the fundamental, while enhancing the growth of the signal at the fundamental. In addition, engineering design considerations of the waveguide wall loading and electron beam fill factor in the waveguide set limits on the waveguide dimensions, the wiggler magnet gap spacing, the wiggler period, and the minimum magnetic field strength in the tapered region of the wiggler. As an example, we shall describe an FEL amplifier designed to produce an average power of about 10 MW at a frequency of 280 GHz to be used for electron cyclotron resonance heating of tokamak fusion devices.

  20. A recirculating linac-based facility for ultrafast X-ray science

    SciTech Connect

    Corlett, J.N; Barletta, W.A.; DeSantis, S.; Doolittle, L.; Fawley, W.M.; Green, M.A.; Heimann, P.; Leone, S.; Lidia, S.; Li, D.; Ratti, A.; Robinson, K.; Schoenlein, R.; Staples, J.; Wan, W.; Wells, R.; Wolski, A.; Zholents, A.; Placidi, M.; Pirkl, W.; Parmigiani, F.

    2003-05-06

    We present an updated design for a proposed source of ultra-fast synchrotron radiation pulses based on a recirculating superconducting linac, in particular the incorporation of EUV and soft x-ray production. The project has been named LUX - Linac-based Ultrafast X-ray facility. The source produces intense x-ray pulses with duration of 10-100 fs at a 10 kHz repetition rate, with synchronization of 10 s fs, optimized for the study of ultra-fast dynamics. The photon range covers the EUV to hard x-ray spectrum by use of seeded harmonic generation in undulators, and a specialized technique for ultra-short-pulse photon production in the 1-10 keV range. High-brightness rf photocathodes produce electron bunches which are optimized either for coherent emission in free-electron lasers, or to provide a large x/y emittance ration and small vertical emittance which allows for manipulation to produce short-pulse hard x-rays. An injector linac accelerates the beam to 120 MeV, and is followed by four passes through a 600-720 MeV recirculating linac. We outline the major technical components of the proposed facility.

  1. A Recirculating Linac-Based Facility for Ultrafast X-Ray Science

    SciTech Connect

    J. N. Corlett; W. A. Barletta; S. DeSantis; L. Doolittle; W. M. Fawley; M.A. Green; P. Heimann; S. Leone; S. Lidia; D. Li; A. Ratti; K. Robinson; R. Schoenlein; J. Staples; W. Wan; R. Wells; A.Wolski; A. Zholents; F. Parmigiani; M. Placidi; W. Pirkl; R. A. Rimmer; S. Wang

    2003-05-01

    We present an updated design for a proposed source of ultra-fast synchrotron radiation pulses based on a recirculating superconducting linac [1,2], in particular the incorporation of EUV and soft x-ray production. The project has been named LUX--Linac-based Ultrafast X-ray facility. The source produces intense x-ray pulses with duration of 10-100 fs at a 10 kHz repetition rate, with synchronization of 10's fs, optimized for the study of ultra-fast dynamics. The photon range covers the EUV to hard x-ray spectrum by use of seeded harmonic generation in undulators, and a specialized technique for ultra-short pulse photon production in the 1-10 keV range. High brightness rf photocathodes produce electron bunches which are optimized either for coherent emission in free electron lasers, or to provide a large x/y emittance ration and small vertical emittance which allows for manipulation to produce short-pulse hard x-rays. An injector linac accelerates the beam to 120 MeV, and is followed by f our passes through a 600-720 MeV recirculating linac. We outline the major technical components of the proposed facility.

  2. Induction-linac based free-electron laser amplifier for fusion applications

    SciTech Connect

    Jong, R.A.; Stone, R.R.

    1988-08-01

    We describe an induction-linac based free-electron laser amplifier design for producing multi-megawatt levels of microwave power for electron cyclotron resonance heating of tokamak fusion devices such as the Compact Ignition Tokamak or the International Thermonuclear Experimental Reactor. The wiggler design strategy incorporates a tapering algorithm suitable for FEL systems with moderate space charge effects and minimizes spontaneous noise growth at frequencies below the fundamental, while enhancing the growth of the signal at the fundamental. In addition, engineering design considerations of the waveguide dimensions, the wiggler magnet gap spacing, the wiggler period, and the minimum magnetic field strength in the tapered region of the wiggler. This FEL is designed to produce an average power of about 10 MW at frequencies in the range from 380 GHz to 560 GHz. The achievement of this average power at a reasonable cost requires a high duty factor, which affects some component design. In addition, the desire to obtain a high extraction efficiency pushes the beam energy up and requires magnetic field strengths in the wiggler that are near or possibly larger than the Halbach limit. We used a methodology for our system study that had been developed earlier. We considered several FEL configurations and selected one that minimized total cost. We determined that increasing the beam energy requires that the wiggler use vanadium-permendur as the pole material. We discuss the basic design of the selected configuration and give the expected performance. 19 refs., 9 figs., 2 tabs.

  3. Effects of irradiation geometry on treatment plan optimization with linac-based radiosurgery.

    PubMed

    Phillips, M H; Stelzer, K J; Mayberg, M R; Winn, H R

    1996-08-01

    A comparison was made of different treatment plans to determine the effect on the three-dimensional dose distributions of varying the allowed parameters in linac-based stereotactic radiosurgery with circular collimators; these parameters are arc position, length, and weighting, and collimator diameter. For the class of eccentrically shaped target volumes that are not so irregular as to require several separate isocenters, it was found that superior dose distributions could be achieved by varying arc length, arc position, arc weighting, and collimator diameter. An analysis of the results achieved with an automated planning program indicates that, in general, the variables of arc position and arc length are of greater importance than collimator size or beam weighting. However, there are cases where varying these latter two parameters does result in markedly better dose distributions. A deeper investigation into the effects of multiple collimators on the dose distribution in the area of steepest gradient demonstrated that multiple collimator sizes do not significantly degrade the dose falloff, which is in fact mostly determined by the effects of intersecting arcs. PMID:8873037

  4. Project for the development of the linac based NCT facility in University of Tsukuba.

    PubMed

    Kumada, H; Matsumura, A; Sakurai, H; Sakae, T; Yoshioka, M; Kobayashi, H; Matsumoto, H; Kiyanagi, Y; Shibata, T; Nakashima, H

    2014-06-01

    A project team headed by University of Tsukuba launched the development of a new accelerator based BNCT facility. In the project, we have adopted Radio-Frequency Quadrupole (RFQ)+Drift Tube Linac (DTL) type linac as proton accelerators. Proton energy generated from the linac was set to 8MeV and average current was 10mA. The linac tube has been constructed by Mitsubishi Heavy Industry Co. For neutron generator device, beryllium is selected as neutron target material; high intensity neutrons are generated by the reaction with beryllium and the 80kW proton beam. Our team chose beryllium as the neutron target material. At present beryllium target system is being designed with Monte-Carlo estimations and heat analysis with ANSYS. The neutron generator consists of moderator, collimator and shielding. It is being designed together with the beryllium target system. We also acquired a building in Tokai village; the building has been renovated for use as BNCT treatment facility. It is noteworthy that the linac tube had been installed in the facility in September 2012. In BNCT procedure, several medical devices are required for BNCT treatment such as treatment planning system, patient positioning device and radiation monitors. Thus these are being developed together with the linac based neutron source. For treatment planning system, we are now developing a new multi-modal Monte-Carlo treatment planning system based on JCDS. The system allows us to perform dose estimation for BNCT as well as particle radiotherapy and X-ray therapy. And the patient positioning device can navigate a patient to irradiation position quickly and properly. Furthermore the device is able to monitor movement of the patient׳s position during irradiation. PMID:24637084

  5. Induction-linac based free electron laser amplifier for fusion applications

    NASA Astrophysics Data System (ADS)

    Jong, R. A.; Stone, R. R.

    1989-12-01

    We describe an induction-linac based free electron laser amplifier design for producing multi-megawatt levels of microwave power for electron cyclotron resonance heating of tokamak fusion devices such as the Compact Ignition Tokamak or the International Thermonuclear Experimental Reactor. The wiggler design strategy incorporates a tapering algorithm suitable for FEL systems with moderate space charge effects and minimizes spontaneous noise growth at frequencies below the fundamental, while enhancing the growth of the signal at the fundamental. In addition, engineering design considerations of the waveguide wall loading and electron beam fill factor in the waveguide set limits on the waveguide dimensions, the wiggler magnet gap spacing, the wiggler period, and the minimum magnetic field strength in the tapered region of the wiggler. This FEL is designed to produce an average power of about 10 MW at frequencies in the range from 280 to 560 GHz. The achievement of this average power at a reasonable cost requires a high duty factor, which affects some component design. In addition, the desire to obtain a high extraction efficiency pushes the beam energy up and requires magnetic field strengths in the wiggler that are near or possibly larger than the Halbach limit. We used a methodology for our system study that had been developed earlier. We considered several FEL configurations and selected one that minimized total cost. We determined that increasing the beam energy requires that the wiggler use vanadium-permendur as the pole material. We discuss the basic design of the selected configuration and give the expected performance.

  6. Compact Short-Pulsed Electron Linac Based Neutron Sources for Precise Nuclear Material Analysis

    NASA Astrophysics Data System (ADS)

    Uesaka, M.; Tagi, K.; Matsuyama, D.; Fujiwara, T.; Dobashi, K.; Yamamoto, M.; Harada, H.

    2015-10-01

    An X-band (11.424GHz) electron linac as a neutron source for nuclear data study for the melted fuel debris analysis and nuclear security in Fukushima is under development. Originally we developed the linac for Compton scattering X-ray source. Quantitative material analysis and forensics for nuclear security will start several years later after the safe settlement of the accident is established. For the purpose, we should now accumulate more precise nuclear data of U, Pu, etc., especially in epithermal (0.1-10 eV) neutrons. Therefore, we have decided to modify and install the linac in the core space of the experimental nuclear reactor "Yayoi" which is now under the decommission procedure. Due to the compactness of the X-band linac, an electron gun, accelerating tube and other components can be installed in a small space in the core. First we plan to perform the time-of-flight (TOF) transmission measurement for study of total cross sections of the nuclei for 0.1-10 eV energy neutrons. Therefore, if we adopt a TOF line of less than 10m, the o-pulse length of generated neutrons should be shorter than 100 ns. Electronenergy, o-pulse length, power, and neutron yield are ~30 MeV, 100 ns - 1 micros, ~0.4 kW, and ~1011 n/s (~103 n/cm2/s at samples), respectively. Optimization of the design of a neutron target (Ta, W, 238U), TOF line and neutron detector (Ce:LiCAF) of high sensitivity and fast response is underway. We are upgrading the electron gun and a buncher to realize higher current and beam power with a reasonable beam size in order to avoid damage of the neutron target. Although the neutron flux is limited in case of the X-band electron linac based source, we take advantage of its short pulse aspect and availability for nuclear data measurement with a short TOF system. First, we form a tentative configuration in the current experimental room for Compton scattering in 2014. Then, after the decommissioning has been finished, we move it to the "Yayoi" room and perform

  7. Fast Monte Carlo Electron-Photon Transport Method and Application in Accurate Radiotherapy

    NASA Astrophysics Data System (ADS)

    Hao, Lijuan; Sun, Guangyao; Zheng, Huaqing; Song, Jing; Chen, Zhenping; Li, Gui

    2014-06-01

    Monte Carlo (MC) method is the most accurate computational method for dose calculation, but its wide application on clinical accurate radiotherapy is hindered due to its poor speed of converging and long computation time. In the MC dose calculation research, the main task is to speed up computation while high precision is maintained. The purpose of this paper is to enhance the calculation speed of MC method for electron-photon transport with high precision and ultimately to reduce the accurate radiotherapy dose calculation time based on normal computer to the level of several hours, which meets the requirement of clinical dose verification. Based on the existing Super Monte Carlo Simulation Program (SuperMC), developed by FDS Team, a fast MC method for electron-photon coupled transport was presented with focus on two aspects: firstly, through simplifying and optimizing the physical model of the electron-photon transport, the calculation speed was increased with slightly reduction of calculation accuracy; secondly, using a variety of MC calculation acceleration methods, for example, taking use of obtained information in previous calculations to avoid repeat simulation of particles with identical history; applying proper variance reduction techniques to accelerate MC method convergence rate, etc. The fast MC method was tested by a lot of simple physical models and clinical cases included nasopharyngeal carcinoma, peripheral lung tumor, cervical carcinoma, etc. The result shows that the fast MC method for electron-photon transport was fast enough to meet the requirement of clinical accurate radiotherapy dose verification. Later, the method will be applied to the Accurate/Advanced Radiation Therapy System ARTS as a MC dose verification module.

  8. Feasibility study on the use of uranium in photoneutron target and BSA optimization for Linac based BNCT

    NASA Astrophysics Data System (ADS)

    Rahmani, Faezeh; Shahriari, Majid; Minoochehr, Abdolhamid; Nedaie, Hasan

    2011-06-01

    A hybrid photoneutron target including natural uranium has been studied for a 20 MeV linear electron accelerator (Linac) based Boron Neutron Capture Therapy (BNCT) facility. In this study the possibility of using uranium to increase the neutron intensity has been investigated by focusing on the time dependence behavior of the build-up and decay of the delayed gamma rays from fission fragments and activation products through photo-fission reactions in the BSA (Beam Shaping Assembly) configuration design. Delayed components of neutrons and photons were calculated. The obtained BSA parameters are in agreement with the IAEA recommendation and compared to the hybrid photoneutron target without U. The epithermal flux in the suggested design is 2.67E9 (n/cm 2s/mA).

  9. Investigating a multi-purpose target for electron linac based photoneutron sources for BNCT of deep-seated tumors

    NASA Astrophysics Data System (ADS)

    Masoudi, S. Farhad; Rasouli, Fatemeh S.

    2015-08-01

    Recent studies in BNCT have focused on investigating appropriate neutron sources as alternatives for nuclear reactors. As the most prominent facilities, the electron linac based photoneutron sources benefit from two consecutive reactions, (e, γ) and (γ, n). The photoneutron sources designed so far are composed of bipartite targets which involve practical problems and are far from the objective of achieving an optimized neutron source. This simulation study deals with designing a compact, optimized, and geometrically simple target for a photoneutron source based on an electron linac. Based on a set of MCNPX simulations, tungsten is found to have the potential of utilizing as both photon converter and photoneutron target. Besides, it is shown that an optimized dimension for such a target slows-down the produced neutrons toward the desired energy range while keeping them economy, which makes achieving the recommended criteria for BNCT of deep-tumors more available. This multi-purpose target does not involve complicated designing, and can be considered as a significant step toward finding application of photoneutron sources for in-hospital treatments. In order to shape the neutron beam emitted from such a target, the beam is planned to pass through an optimized arrangement of materials composed of moderators, filters, reflector, and collimator. By assessment with the recommended in-air parameters, it is shown that the designed beam provides high intensity of desired neutrons, as well as low background contamination. The last section of this study is devoted to investigate the performance of the resultant beam in deep tissue. A typical simulated liver tumor, located within a phantom of human body, was subjected to the irradiation of the designed spectrum. The dosimetric results, including evaluated depth-dose curves and carried out in-phantom parameters show that the proposed configuration establishes acceptable agreement between the appropriate neutron intensity, and

  10. Single Fraction Versus Fractionated Linac-Based Stereotactic Radiotherapy for Vestibular Schwannoma: A Single-Institution Experience

    SciTech Connect

    Collen, Christine; Ampe, Ben; Gevaert, Thierry; Moens, Maarten; Linthout, Nadine; De Ridder, Mark; Verellen, Dirk; D'Haens, Jean; Storme, Guy

    2011-11-15

    Purpose: To evaluate and compare outcomes for patients with vestibular schwannoma (VS) treated in a single institution with linac-based stereotactic radiosurgery (SRS) or by fractionated stereotactic radiotherapy (SRT). Methods and Materials: One hundred and nineteen patients (SRS = 78, SRT = 41) were treated. For both SRS and SRT, beam shaping is performed by a mini-multileaf collimator. For SRS, a median single dose of 12.5 Gy (range, 11-14 Gy), prescribed to the 80% isodose line encompassing the target, was applied. Of the 42 SRT treatments, 32 treatments consisted of 10 fractions of 3-4 Gy, and 10 patients received 25 sessions of 2 Gy, prescribed to the 100% with the 95% isodose line encompassing the planning target volume. Mean largest tumor diameter was 16.6 mm in the SRS and 24.6 mm in the SRT group. Local tumor control, cranial nerve toxicity, and preservation of useful hearing were recorded. Any new treatment-induced cranial nerve neuropathy was scored as a complication. Results: Median follow-up was 62 months (range, 6-136 months), 5 patients progressed, resulting in an overall 5-year local tumor control of 95%. The overall 5-year facial nerve preservation probability was 88% and facial nerve neuropathy was statistically significantly higher after SRS, after prior surgery, for larger tumors, and in Koos Grade {>=}3. The overall 5-year trigeminal nerve preservation probability was 96%, not significantly influenced by any of the risk factors. The overall 4-year probability of preservation of useful hearing (Gardner-Robertson score 1 or 2) was 68%, not significantly different between SRS or SRT (59% vs. 82%, p = 0.089, log rank). Conclusion: Linac-based RT results in good local control and acceptable clinical outcome in small to medium-sized vestibular schwannomas (VSs). Radiosurgery for large VSs (Koos Grade {>=}3) remains a challenge because of increased facial nerve neuropathy.

  11. Physical parameters of very small diameter 10 MV X-ray beams for linac-based stereotactic radiosurgery

    NASA Astrophysics Data System (ADS)

    Sham, Edwin

    Physical aspects of very small diameter X-ray beams used for a linac-based stereotactic radiosurgery are presented in this thesis. A 10 MV linac was used as the radiation source. Very small 10 MV photon fields with diameters of 1.5 mm, 3 mm, and 5 mm are produced by special collimators attached to the treatment head of the linac. The radiation beam data were measured with a small field diode detector as well as radiographic and radiochromic films. Measured beam parameters were compared with the same parameters calculated with Monte Carlo (MC) simulations. For very small photon fields with diameters on the order of the focal spot size, MC calculations show that both the percentage depth dose (PDD) distributions and dose profiles are sensitive to the focal spot size. A simple sliding slit technique was developed to measure the focal spot size and shape for accurate MC simulations of very small diameter beams. The measured focal spot of the 10 MV linac is elliptical in shape and fitted by a Gaussian distribution with full-widths-at-half-maximum (FWHMs) of 2.05 mm and 1.34 mm in the principal axes of the ellipse. A Gaussian circle equivalent in area to the experimentally determined focal spot ellipse was used in MC simulations. The resulting PDD and beam profile calculations are in good agreement with the measurements. Dynamic radiosurgery with very small diameter photon beams was carried out using the 10 MV linac. Radiosurgical isodose distributions were measured with radiographic films in a spherical head phantom and calculated with the MC technique. A good agreement between the measured and MC-calculated isodose distributions for very small diameter fields is achieved. The displacement of the center of the measured isodose distributions relative to the laser-defined isocenter was on the order of 0.7 mm. All these results show the potential of linac-based radiosurgery with very small diameter photon beams for clinical use.

  12. Poster — Thur Eve — 55: An automated XML technique for isocentre verification on the Varian TrueBeam

    SciTech Connect

    Asiev, Krum; Mullins, Joel; DeBlois, François; Liang, Liheng; Syme, Alasdair

    2014-08-15

    Isocentre verification tests, such as the Winston-Lutz (WL) test, have gained popularity in the recent years as techniques such as stereotactic radiosurgery/radiotherapy (SRS/SRT) treatments are more commonly performed on radiotherapy linacs. These highly conformal treatments require frequent monitoring of the geometrical accuracy of the isocentre to ensure proper radiation delivery. At our clinic, the WL test is performed by acquiring with the EPID a collection of 8 images of a WL phantom fixed on the couch for various couch/gantry angles. This set of images is later analyzed to determine the isocentre size. The current work addresses the acquisition process. A manual WL test acquisition performed by and experienced physicist takes in average 25 minutes and is prone to user manipulation errors. We have automated this acquisition on a Varian TrueBeam STx linac (Varian, Palo Alto, USA). The Varian developer mode allows the execution of custom-made XML script files to control all aspects of the linac operation. We have created an XML-WL script that cycles through each couch/gantry combinations taking an EPID image at each position. This automated acquisition is done in less than 4 minutes. The reproducibility of the method was verified by repeating the execution of the XML file 5 times. The analysis of the images showed variation of the isocenter size less than 0.1 mm along the X, Y and Z axes and compares favorably to a manual acquisition for which we typically observe variations up to 0.5 mm.

  13. LEPS2 : the second Laser-Electron Photon facility at SPring-8

    NASA Astrophysics Data System (ADS)

    Yosoi, M.

    2011-10-01

    A new project to construct the second beamline for the laser-electron photon beam at SPring-8 (LEPS2) has started. Based on the LEPS experience, the project aims to improve the intensity of the photon beam and to expand the detector acceptance by adopting the BNL-E949 detector, which is a hermetic detector in a large 1 T solenoid magnet. The central region of tracking chambers will be upgraded for the LEPS2. A new LEPS2 experimental building has just been constructed outside the experimental hall of the storage ring. The present status of the development of a frozen-spin polarized HD target is also reported.

  14. Novel layered two-dimensional semiconductors as the building blocks for nano-electronic/photonic systems

    NASA Astrophysics Data System (ADS)

    Su, Guoxiong; De, Debtanu; Hadjiev, Viktor G.; Peng, Haibing

    2014-06-01

    Layered two-dimensional (2D) semiconductors beyond graphene have been emerging as potential building blocks for the next-generation electronic/photonic applications. Representative metal chalcogenides, including the widely studied MoS2, possess similar layered crystal structures with weak interaction between adjacent layers, thus allowing the formation of stable thin-layer crystals with thickness down to a few or even single atomic layer. Other important chalcogenides, involving earth-abundant and environment-friendly materials desirable for sustainable applications, include SnS2 (band gap: 2.1 eV) and SnS (band gap: 1.1 eV). So far, commonly adopted for research purpose are mechanical and liquid exfoliation methods for creating thin layers of such 2D semiconductors. Most recently, chemical vapor deposition (CVD) was attracting significant attention as a practical method for producing thin films or crystal grains of MoS2. However, critical yet still absent is an effective experimental approach for controlling the positions of thin crystal grains of layered 2D semiconductors during the CVD process. Here we report the controlled CVD synthesis of thin crystal arrays of representative layered semiconductors (including SnS2 and SnS) at designed locations on chip, promising large-scale optoelectronic applications. Our work opens a window for future practical applications of layered 2D semiconductors in integrated nano-electronic/photonic systems.

  15. Program EPICP: Electron photon interaction code, photon test module. Version 94.2

    SciTech Connect

    Cullen, D.E.

    1994-09-01

    The computer code EPICP performs Monte Carlo photon transport calculations in a simple one zone cylindrical detector. Results include deposition within the detector, transmission, reflection and lateral leakage from the detector, as well as events and energy deposition as a function of the depth into the detector. EPICP is part of the EPIC (Electron Photon Interaction Code) system. EPICP is designed to perform both normal transport calculations and diagnostic calculations involving only photons, with the objective of developing optimum algorithms for later use in EPIC. The EPIC system includes other modules that are designed to develop optimum algorithms for later use in EPIC; this includes electron and positron transport (EPICE), neutron transport (EPICN), charged particle transport (EPICC), geometry (EPICG), source sampling (EPICS). This is a modular system that once optimized can be linked together to consider a wide variety of particles, geometries, sources, etc. By design EPICP only considers photon transport. In particular it does not consider electron transport so that later EPICP and EPICE can be used to quantitatively evaluate the importance of electron transport when starting from photon sources. In this report I will merely mention where we expect the results to significantly differ from those obtained considering only photon transport from that obtained using coupled electron-photon transport.

  16. ITS Version 6 : the integrated TIGER series of coupled electron/photon Monte Carlo transport codes.

    SciTech Connect

    Franke, Brian Claude; Kensek, Ronald Patrick; Laub, Thomas William

    2008-04-01

    ITS is a powerful and user-friendly software package permitting state-of-the-art Monte Carlo solution of lineartime-independent coupled electron/photon radiation transport problems, with or without the presence of macroscopic electric and magnetic fields of arbitrary spatial dependence. Our goal has been to simultaneously maximize operational simplicity and physical accuracy. Through a set of preprocessor directives, the user selects one of the many ITS codes. The ease with which the makefile system is applied combines with an input scheme based on order-independent descriptive keywords that makes maximum use of defaults and internal error checking to provide experimentalists and theorists alike with a method for the routine but rigorous solution of sophisticated radiation transport problems. Physical rigor is provided by employing accurate cross sections, sampling distributions, and physical models for describing the production and transport of the electron/photon cascade from 1.0 GeV down to 1.0 keV. The availability of source code permits the more sophisticated user to tailor the codes to specific applications and to extend the capabilities of the codes to more complex applications. Version 6, the latest version of ITS, contains (1) improvements to the ITS 5.0 codes, and (2) conversion to Fortran 90. The general user friendliness of the software has been enhanced through memory allocation to reduce the need for users to modify and recompile the code.

  17. Deflecting RF cavity design for a recirculating linac based facility for ultrafast X-ray science (LUX)

    SciTech Connect

    Li, Derun; Corlett, J.N.

    2003-05-01

    We report on superconducting deflecting RF cavity designs for a Recirculating Linac Based Facility for Ultrafast X-ray Science (LUX) at Lawrence Berkeley National Laboratory. The deflecting cavities operate in the lowest dipole mode and are required to produce a temporal correlation within flat electron bunches, as needed for x-ray compression in crystal optics. Deflecting voltage of up to 8.5-MV is required at 3.9-GHz. We present a 7-cell cavity design in this paper. Seven such cavities are required to generate the 8.5 MV deflecting voltage. Longitudinal and transverse impedance from LOM (lower order mode) and HOM (higher order mode) are simulated using the MAFIA code. Short-range and long-range wakefield excited through these impedances are calculated. Beam loading effects of the deflecting mode and LOM modes are estimated. Q values of the LOM monopole modes in the cavity may need to be damped to be below 10{sup 4}-10{sup 5} levels in order to maintain the required energy spread.

  18. Intra-operative 3D guidance and edema detection in prostate brachytherapy using a non-isocentric C-arm

    PubMed Central

    Jain, A.; Deguet, A.; Iordachita, I.; Chintalapani, G.; Vikal, S.; Blevins, J.; Le, Y.; Armour, E.; Burdette, C.; Song, D.; Fichtinger, G.

    2015-01-01

    Purpose Brachytherapy (radioactive seed insertion) has emerged as one of the most effective treatment options for patients with prostate cancer, with the added benefit of a convenient outpatient procedure. The main limitation in contemporary brachytherapy is faulty seed placement, predominantly due to the presence of intra-operative edema (tissue expansion). Though currently not available, the capability to intra-operatively monitor the seed distribution, can make a significant improvement in cancer control. We present such a system here. Methods Intra-operative measurement of edema in prostate brachytherapy requires localization of inserted radioactive seeds relative to the prostate. Seeds were reconstructed using a typical non-isocentric C-arm, and exported to a commercial brachytherapy treatment planning system. Technical obstacles for 3D reconstruction on a non-isocentric C-arm include pose-dependent C-arm calibration; distortion correction; pose estimation of C-arm images; seed reconstruction; and C-arm to TRUS registration. Results In precision-machined hard phantoms with 40–100 seeds and soft tissue phantoms with 45–87 seeds, we correctly reconstructed the seed implant shape with an average 3D precision of 0.35 mm and 0.24 mm, respectively. In a DoD Phase-1 clinical trial on six patients with 48–82 planned seeds, we achieved intra-operative monitoring of seed distribution and dosimetry, correcting for dose inhomogeneities by inserting an average of over four additional seeds in the six enrolled patients (minimum 1; maximum 9). Additionally, in each patient, the system automatically detected intra-operative seed migration induced due to edema (mean 3.84 mm, STD 2.13 mm, Max 16.19 mm). Conclusions The proposed system is the first of a kind that makes intra-operative detection of edema (and subsequent re-optimization) possible on any typical non-isocentric C-arm, at negligible additional cost to the existing clinical installation. It achieves a

  19. ITS; The intergrated TIGER series of electron/photon transport codes-version 3. 0

    SciTech Connect

    Halbleib, J. A.; Kensek, R.P. ); Valdez, G.D. ); Seltzer, S.M.; Berger, M.J. )

    1992-08-01

    This paper reports on the ITS system which is a powerful and use-friendly software package permitting state-of-the-art Monte Carlo solution of linear time-independent coupled electron/photon radiation transport problems, with or without the presence of macroscopic electric and magnetic fields of arbitrary spatial dependence. Version 3.0 is a major upgrade of the system with important improvements in the physical model, variance reduction, I/O, and user friendliness. Improvements to the cross-section generator include the replacement of Born-approximation bremsstrahlung cross sections with the results of numerical phase-shift calculations, the addition of coherent scattering and binding effects in incoherent scattering, an upgrade of collisional and radiative stopping powers, and a complete rewrite to Fortran 77 standards emphasizing Block-IF structure.

  20. Parallel FE Electron-Photon Transport Analysis on 2-D Unstructured Mesh

    SciTech Connect

    Drumm, C.R.; Lorenz, J.

    1999-03-02

    A novel solution method has been developed to solve the coupled electron-photon transport problem on an unstructured triangular mesh. Instead of tackling the first-order form of the linear Boltzmann equation, this approach is based on the second-order form in conjunction with the conventional multi-group discrete-ordinates approximation. The highly forward-peaked electron scattering is modeled with a multigroup Legendre expansion derived from the Goudsmit-Saunderson theory. The finite element method is used to treat the spatial dependence. The solution method is unique in that the space-direction dependence is solved simultaneously, eliminating the need for the conventional inner iterations, a method that is well suited for massively parallel computers.

  1. Space applications of the MITS electron-photon Monte Carlo transport code system

    SciTech Connect

    Kensek, R.P.; Lorence, L.J.; Halbleib, J.A.; Morel, J.E.

    1996-07-01

    The MITS multigroup/continuous-energy electron-photon Monte Carlo transport code system has matured to the point that it is capable of addressing more realistic three-dimensional adjoint applications. It is first employed to efficiently predict point doses as a function of source energy for simple three-dimensional experimental geometries exposed to simulated uniform isotropic planar sources of monoenergetic electrons up to 4.0 MeV. Results are in very good agreement with experimental data. It is then used to efficiently simulate dose to a detector in a subsystem of a GPS satellite due to its natural electron environment, employing a relatively complex model of the satellite. The capability for survivability analysis of space systems is demonstrated, and results are obtained with and without variance reduction.

  2. Integrated TIGER Series of Coupled Electron/Photon Monte Carlo Transport Codes System.

    Energy Science and Technology Software Center (ESTSC)

    2012-11-30

    Version: 00 Distribution is restricted to US Government Agencies and Their Contractors Only. The Integrated Tiger Series (ITS) is a powerful and user-friendly software package permitting state-of-the-art Monte Carlo solution of linear time-independent coupled electron/photon radiation transport problems, with or without the presence of macroscopic electric and magnetic fields of arbitrary spatial dependence. The goal has been to simultaneously maximize operational simplicity and physical accuracy. Through a set of preprocessor directives, the user selects onemore » of the many ITS codes. The ease with which the makefile system is applied combines with an input scheme based on order-independent descriptive keywords that makes maximum use of defaults and internal error checking to provide experimentalists and theorists alike with a method for the routine but rigorous solution of sophisticated radiation transport problems. Physical rigor is provided by employing accurate cross sections, sampling distributions, and physical models for describing the production and transport of the electron/photon cascade from 1.0 GeV down to 1.0 keV. The availability of source code permits the more sophisticated user to tailor the codes to specific applications and to extend the capabilities of the codes to more complex applications. Version 6, the latest version of ITS, contains (1) improvements to the ITS 5.0 codes, and (2) conversion to Fortran 95. The general user friendliness of the software has been enhanced through memory allocation to reduce the need for users to modify and recompile the code.« less

  3. Integrated TIGER Series of Coupled Electron/Photon Monte Carlo Transport Codes System.

    SciTech Connect

    VALDEZ, GREG D.

    2012-11-30

    Version: 00 Distribution is restricted to US Government Agencies and Their Contractors Only. The Integrated Tiger Series (ITS) is a powerful and user-friendly software package permitting state-of-the-art Monte Carlo solution of linear time-independent coupled electron/photon radiation transport problems, with or without the presence of macroscopic electric and magnetic fields of arbitrary spatial dependence. The goal has been to simultaneously maximize operational simplicity and physical accuracy. Through a set of preprocessor directives, the user selects one of the many ITS codes. The ease with which the makefile system is applied combines with an input scheme based on order-independent descriptive keywords that makes maximum use of defaults and internal error checking to provide experimentalists and theorists alike with a method for the routine but rigorous solution of sophisticated radiation transport problems. Physical rigor is provided by employing accurate cross sections, sampling distributions, and physical models for describing the production and transport of the electron/photon cascade from 1.0 GeV down to 1.0 keV. The availability of source code permits the more sophisticated user to tailor the codes to specific applications and to extend the capabilities of the codes to more complex applications. Version 6, the latest version of ITS, contains (1) improvements to the ITS 5.0 codes, and (2) conversion to Fortran 95. The general user friendliness of the software has been enhanced through memory allocation to reduce the need for users to modify and recompile the code.

  4. SU-E-J-70: Evaluation of Multiple Isocentric Intensity Modulated and Volumetric Modulated Arc Therapy Techniques Using Portal Dosimetry

    SciTech Connect

    Muralidhar, K Raja; Pangam, S; Kolla, J; Ponaganti, S; Ali, M; Vuba, S; Mariyappan, P; Babaiah, M; Komanduri, K

    2015-06-15

    Purpose: To develop a method for verification of dose distribution in a patient during treatment using multiple isocentric Intensity modulated and volumetric modulated arc therapy techniques with portal dosimetry. Methods: Varian True Beam accelerator, equipped with an aS1000 megavoltage electronic portal imaging device (EPID) has an integrated image mode for portal dosimetry (PD). The source-to-imager distance was taken at 150 cm to avoid collision to the table. Fourteen fractions were analyzed for this study. During shift in a single plan from one isocenter to another isocenter, EPID also shifted longitudinally for each field by taking the extent of divergence of beam into the consideration for EPID distance of 150cm. Patients were given treatment everyday with EPID placed in proper position for each field. Several parameters were obtained by comparing the dose distribution between fractions to fraction. The impact of the intra-fraction and inter-fraction of the patient in combination with isocenter shift of the beams were observed. Results: During treatment, measurements were performed by EPID and were evaluated by the gamma method. Analysis was done between fractions for multiple isocenter treatments. The pass rates of the gamma analysis with a criterion of 3% and 3 mm for the 14 fractions were over 97.8% with good consistency. Whereas maximum gamma exceeded the criteria in few fractions (in<1 cc vol). Average gamma was observed in the criteria of 0.5%. Maximum dose difference and average dose differences were less than 0.22 CU and 0.01 CU for maximum tolerance of 1.0 CU and 0.2 CU respectively. Conclusion: EPID with extended distance is ideal method to verify the multiple isocentric dose distribution in patient during treatment, especially cold and hot spots in junction dose. Verification of shifts as well as the dose differences between each fraction due to inter-fraction and intra-fraction of the patient can be derived.

  5. Extension of the Integrated Tiger Series (ITS) of electron-photon Monte Carlo codes to 100 GeV

    SciTech Connect

    Miller, S.G.

    1988-08-01

    Version 2.1 of the Integrated Tiger Series (ITS) of electron-photon Monte Carlo codes was modified to extend their ability to model interactions up to 100 GeV. Benchmarks against experimental results conducted at 10 and 15 GeV confirm the accuracy of the extended codes. 12 refs., 2 figs., 2 tabs.

  6. Utilization of optical tracking to validate a software-driven isocentric approach to robotic couch movements for proton radiotherapy

    SciTech Connect

    Hsi, Wen C. E-mail: Wenchien.hsi@sphic.org.cn; Zeidan, Omar A.; Law, Aaron; Schreuder, Andreas N.

    2014-08-15

    Purpose: An optical tracking and positioning system (OTPS) was developed to validate the software-driven isocentric (SDI) approach to control the six-degrees-of-freedom movement of a robotic couch. Methods: The SDI approach to movements rotating around a predefined isocenter, referred to as a GeoIso, instead of a mechanical pivot point was developed by the robot automation industry. With robotic couch-sag corrections for weight load in a traditional SDI approach, movements could be accurately executed for a GeoIso located within a 500 mm cubic volume on the couch for treatments. The accuracy of SDI movement was investigated using the OTPS. The GeoIso was assumed to align with the proton beam isocenter (RadIso) for gantry at the reference angle. However, the misalignment between GeoIso and RadIso was quantitatively investigated by measuring the displacements at various couch angles for a target placed at the RadIso at an initial couch angle. When circular target displacements occur on a plane, a relative isocenter shift (RIS) correction could be applied in the SDI movement to minimize target displacements. Target displacements at a fixed gantry angle without and with RIS correction were measured for 12 robotic couches. Target displacements for various gantry angles were performed on three couches in gantry rooms to study the gantry-induced RadIso shift. The RIS correction can also be applied for the RadIso shift. A new SDI approach incorporating the RIS correction with the couch sag is described in this study. In parallel, the accuracy of SDI translation movements for various weight loads of patients on the couch was investigated during positioning of patients for proton prostate treatments. Results: For a fixed gantry angle, measured target displacements without RIS correction for couch rotations in the horizontal plane varied from 4 to 20 mm. However, measured displacements perpendicular to couch rotation plane were about 2 mm for all couches. Extracted

  7. Self-Adjoint Angular Flux Equation for Coupled Electron-Photon Transport

    SciTech Connect

    Liscum-Powell, J.L.; Lorence, L.J. Jr.; Morel, J.E.; Prinja, A.K.

    1999-07-08

    Recently, Morel and McGhee described an alternate second-order form of the transport equation called the self adjoint angular flux (SAAF) equation that has the angular flux as its unknown. The SAAF formulation has all the advantages of the traditional even- and odd-parity self-adjoint equations, with the added advantages that it yields the full angular flux when it is numerically solved, it is significantly easier to implement reflective and reflective-like boundary conditions, and in the appropriate form it can be solved in void regions. The SAAF equation has the disadvantage that the angular domain is the full unit sphere and, like the even- and odd- parity form, S{sub n} source iteration cannot be implemented using the standard sweeping algorithm. Also, problems arise in pure scattering media. Morel and McGhee demonstrated the efficacy of the SAAF formulation for neutral particle transport. Here we apply the SAAF formulation to coupled electron-photon transport problems using multigroup cross-sections from the CEPXS code and S{sub n} discretization.

  8. Measurement of the ionic emission generated by an electron-photon conversion target

    NASA Astrophysics Data System (ADS)

    Compant La Fontaine, A.; Guilhem, D.; Lemaire, J. L.

    2002-08-01

    A time-of-flight diagnostic made of a double sheet sensor has been designed for the search of ions emitted by an electron-photon conversion target under the impact of an intense relativistic electron beam. This device was tested on the PIVAIR prototype accelerator. Signals attributed to ions emitted from the target were observed for different target elements. The ions C + and H + were identified by time-of-flight measurements, and their mean velocities were found to be equal to about 1.6×10 8 and 5×10 8 cm/s for C and Ta targets, respectively. The appearance, rise time and saturation values of the ionic current are close to those obtained from preliminary calculations based on an ionic emission model (VAPOR) which has been coupled to a Maxwell-Vlasov PIC code (M2V). The ionic current signal is characterised by a plateau, the level of which corresponds to the Child-Langmuir current (25 A for H + ions). Furthermore, the fall-off of this signal is synchronised with the electron beam one. This behaviour represents the de-confinement of the ion beam under the effect of its own space charge.

  9. A simplified spherical harmonic method for coupled electron-photon transport calculations

    SciTech Connect

    Josef, J.A.

    1997-12-01

    In this thesis the author has developed a simplified spherical harmonic method (SP{sub N} method) and associated efficient solution techniques for 2-D multigroup electron-photon transport calculations. The SP{sub N} method has never before been applied to charged-particle transport. He has performed a first time Fourier analysis of the source iteration scheme and the P{sub 1} diffusion synthetic acceleration (DSA) scheme applied to the 2-D SP{sub N} equations. The theoretical analyses indicate that the source iteration and P{sub 1} DSA schemes are as effective for the 2-D SP{sub N} equations as for the 1-D S{sub N} equations. In addition, he has applied an angular multigrid acceleration scheme, and computationally demonstrated that it performs as well as for the 2-D SP{sub N} equations as for the 1-D S{sub N} equations. It has previously been shown for 1-D S{sub N} calculations that this scheme is much more effective than the DSA scheme when scattering is highly forward-peaked. The author has investigated the applicability of the SP{sub N} approximation to two different physical classes of problems: satellite electronics shielding from geomagnetically trapped electrons, and electron beam problems.

  10. Means and method for calibrating a photon detector utilizing electron-photon coincidence

    NASA Technical Reports Server (NTRS)

    Srivastava, S. K. (Inventor)

    1984-01-01

    An arrangement for calibrating a photon detector particularly applicable for the ultraviolet and vacuum ultraviolet regions is based on electron photon coincidence utilizing crossed electron beam atom beam collisions. Atoms are excited by electrons which lose a known amount of energy and scatter with a known remaining energy, while the excited atoms emit photons of known radiation. Electrons of the known remaining energy are separated from other electrons and are counted. Photons emitted in a direction related to the particular direction of scattered electrons are detected to serve as a standard. Each of the electrons is used to initiate the measurements of a time interval which terminates with the arrival of a photon exciting the photon detector. Only the number of time intervals related to the coincidence correlation and of electrons scattered in the particular direction with the known remaining energy and photons of a particular radiation level emitted due to the collisions of such scattered electrons are counted. The detector calibration is related to the number of counted electrons and photons.

  11. Anisotropic Electron-Photon and Electron-Phonon Interactions in Black Phosphorus

    SciTech Connect

    Ling, Xi; Huang, Shengxi; Hasdeo, Eddwi; Parkin, William; Gracio, Jose; Tatsumi, Yuki; Nugraha, Ahmad; Puretzky, Alexander A; Das, Paul; Sumpter, Bobby G; Geohegan, David B; Kong, Jing; Saito, Riichiro; Drndic, Marija; Meunier, Vincent; Dresselhaus, M

    2016-01-01

    Orthorhombic black phosphorus (BP) and other layered materials, such as gallium telluride (GaTe) and tin selenide (SnSe), stand out among two-dimensional (2D) materials owing to their anisotropic in-plane structure. This anisotropy adds a new dimension to the properties of 2D materials and stimulates the development of angle-resolved photonics and electronics. However, understanding the effect of anisotropy has remained unsatisfactory to-date, as shown by a number of inconsistencies in the recent literatures. We use angle-resolved absorption and Raman spectroscopies to investigate the role of anisotropy on the electron-photon and electron-phonon interactions in BP. We highlight a non-trivial dependence between anisotropies and flake thickness, photon and phonon energies. We show that once understood, the anisotropic optical absorption appears to be a reliable and simple way to identify the crystalline orientation of BP, which cannot be determined from Raman spectroscopy without the explicit consideration of excitation wavelength and flake thickness, as commonly used previously.

  12. Anisotropic Electron-Photon and Electron-Phonon Interactions in Black Phosphorus

    DOE PAGESBeta

    Ling, Xi; Huang, Shengxi; Hasdeo, Eddwi; Liang, Liangbo; Parkin, William; Tatsumi, Yuki; Nugraha, Ahmad; Puretzky, Alexander A; Das, Paul; Sumpter, Bobby G; et al

    2016-03-10

    Orthorhombic black phosphorus (BP) and other layered materials, such as gallium telluride (GaTe) and tin selenide (SnSe), stand out among two-dimensional (2D) materials owing to their anisotropic in-plane structure. This anisotropy adds a new dimension to the properties of 2D materials and stimulates the development of angle-resolved photonics and electronics. However, understanding the effect of anisotropy has remained unsatisfactory to-date, as shown by a number of inconsistencies in the recent literatures. We use angle-resolved absorption and Raman spectroscopies to investigate the role of anisotropy on the electron-photon and electron-phonon interactions in BP. We highlight a non-trivial dependence between anisotropies andmore » flake thickness, photon and phonon energies. We show that once understood, the anisotropic optical absorption appears to be a reliable and simple way to identify the crystalline orientation of BP, which cannot be determined from Raman spectroscopy without the explicit consideration of excitation wavelength and flake thickness, as commonly used previously.« less

  13. Anisotropic Electron-Photon and Electron-Phonon Interactions in Black Phosphorus.

    PubMed

    Ling, Xi; Huang, Shengxi; Hasdeo, Eddwi H; Liang, Liangbo; Parkin, William M; Tatsumi, Yuki; Nugraha, Ahmad R T; Puretzky, Alexander A; Das, Paul Masih; Sumpter, Bobby G; Geohegan, David B; Kong, Jing; Saito, Riichiro; Drndic, Marija; Meunier, Vincent; Dresselhaus, Mildred S

    2016-04-13

    Orthorhombic black phosphorus (BP) and other layered materials, such as gallium telluride (GaTe) and tin selenide (SnSe), stand out among two-dimensional (2D) materials owing to their anisotropic in-plane structure. This anisotropy adds a new dimension to the properties of 2D materials and stimulates the development of angle-resolved photonics and electronics. However, understanding the effect of anisotropy has remained unsatisfactory to date, as shown by a number of inconsistencies in the recent literature. We use angle-resolved absorption and Raman spectroscopies to investigate the role of anisotropy on the electron-photon and electron-phonon interactions in BP. We highlight, both experimentally and theoretically, a nontrivial dependence between anisotropy and flake thickness and photon and phonon energies. We show that once understood, the anisotropic optical absorption appears to be a reliable and simple way to identify the crystalline orientation of BP, which cannot be determined from Raman spectroscopy without the explicit consideration of excitation wavelength and flake thickness, as commonly used previously. PMID:26963685

  14. Performance of a Novel Repositioning Head Frame for Gamma Knife Perfexion and Image-Guided Linac-Based Intracranial Stereotactic Radiotherapy

    SciTech Connect

    Ruschin, Mark; Nayebi, Nazanin; Carlsson, Per; Brown, Kevin

    2010-09-01

    Purpose: To evaluate the geometric positioning and immobilization performance of a vacuum bite-block repositioning head frame (RHF) system for Perfexion (PFX-SRT) and linac-based intracranial image-guided stereotactic radiotherapy (SRT). Methods and Materials: Patients with intracranial tumors received linac-based image-guided SRT using the RHF for setup and immobilization. Three hundred thirty-three fractions of radiation were delivered in 12 patients. The accuracy of the RHF was estimated for linac-based SRT with online cone-beam CT (CBCT) and for PFX-SRT with a repositioning check tool (RCT) and offline CBCT. The RCT's ability to act as a surrogate for anatomic position was estimated through comparison to CBCT image matching. Immobilization performance was evaluated daily with pre- and postdose delivery CBCT scans and RCT measurements. Results: The correlation coefficient between RCT- and CBCT-reported displacements was 0.59, 0.75, 0.79 (Right, Superior, and Anterior, respectively). For image-guided linac-based SRT, the mean three-dimensional (3D) setup error was 0.8 mm with interpatient ({Sigma}) and interfraction ({sigma}) variations of 0.1 and 0.4 mm, respectively. For PFX-SRT, the initial, uncorrected mean 3D positioning displacement in stereotactic coordinates was 2.0 mm, with {Sigma} = 1.1 mm and {sigma} = 0.8 mm. Considering only RCT setups <1mm (PFX action level) the mean 3D positioning displacement reduced to 1.3 mm, with {Sigma} = 0.9 mm and {sigma} = 0.4 mm. The largest contributing systematic uncertainty was in the superior-inferior direction (mean displacement = -0.5 mm; {Sigma} = 0.9 mm). The largest mean rotation was 0.6{sup o} in pitch. The mean 3D intrafraction motion was 0.4 {+-} 0.3 mm. Conclusion: The RHF provides excellent immobilization for intracranial SRT and PFX-SRT. Some small systematic uncertainties in stereotactic positioning exist and must be considered when generating PFX-SRT treatment plans. The RCT provides reasonable surrogacy

  15. Electron-Photon Polarization Correlation Study of Neon, Argon and Krypton Excitation by Electron Impact

    NASA Astrophysics Data System (ADS)

    Zheng, Shuanghai

    1993-01-01

    The electron impact excitation of the 3s ^' (1/2) ^0_1 state in neon, the 4s^' (1/2) ^0_1 state in argon and the 5s (3/2) ^0_1 state in krypton have been studied using the electron-photon polarization correlation technique. The two linear coherence parameters P_1 and P_2 have been measured and the alignment angle gamma and the linear polarization P ^+_{rm lin} of the angular part of the collisionally induced excited state charge cloud were extracted from the measured P _1 and P_2 parameters. We measured P_1 and P_2 in neon at an impact energy of 50 eV, in argon at impact energies of 50 eV, 40 eV, 30 eV and 25 eV, and in krypton at impact energies of 50 eV and 30 eV and electron scattering angles up to 55^circ in all cases. A comparison with theoretical predictions from first-order perturbative theories such as a Distorted Wave Born Approximation (DWBA) and a First Order Many Body Theory (FOMBT) was made. At 50 eV in neon and argon, the agreement between experiment and theory is generally good at small scattering angles up to 25^circ and somewhat poorer at larger scattering angles. At 50 eV in krypton, the agreement between experiment and theory is generally good at scattering angles up to 40 ^circ. The measurements in argon (40 eV, 30 eV, and 25 eV) generally follow the trend of the theoretical predictions, but it was found that the experimentally measured coherence parameters appear to be shifted towards larger scattering angles compared to the theoretical predictions as the impact energy is decreased. At 30 eV in krypton, very good agreement between experiment and theory was found over the entire range of electron scattering angles (up to 55^circ). The level of agreement between experiment and theory indicates that the DWBA and FOMBT appear to provide a better description of the collision process for a more complex target. We also found that the alignment angle gamma is the parameter which is perhaps least sensitive to the details of the collision.

  16. A simplified spherical harmonic method for coupled electron-photon transport calculations

    SciTech Connect

    Josef, J.A.

    1996-12-01

    In this thesis we have developed a simplified spherical harmonic method (SP{sub N} method) and associated efficient solution techniques for 2-D multigroup electron-photon transport calculations. The SP{sub N} method has never before been applied to charged-particle transport. We have performed a first time Fourier analysis of the source iteration scheme and the P{sub 1} diffusion synthetic acceleration (DSA) scheme applied to the 2-D SP{sub N} equations. Our theoretical analyses indicate that the source iteration and P{sub 1} DSA schemes are as effective for the 2-D SP{sub N} equations as for the 1-D S{sub N} equations. Previous analyses have indicated that the P{sub 1} DSA scheme is unstable (with sufficiently forward-peaked scattering and sufficiently small absorption) for the 2-D S{sub N} equations, yet is very effective for the 1-D S{sub N} equations. In addition, we have applied an angular multigrid acceleration scheme, and computationally demonstrated that it performs as well for the 2-D SP{sub N} equations as for the 1-D S{sub N} equations. It has previously been shown for 1-D S{sub N} calculations that this scheme is much more effective than the DSA scheme when scattering is highly forward-peaked. We have investigated the applicability of the SP{sub N} approximation to two different physical classes of problems: satellite electronics shielding from geomagnetically trapped electrons, and electron beam problems. In the space shielding study, the SP{sub N} method produced solutions that are accurate within 10% of the benchmark Monte Carlo solutions, and often orders of magnitude faster than Monte Carlo. We have successfully modeled quasi-void problems and have obtained excellent agreement with Monte Carlo. We have observed that the SP{sub N} method appears to be too diffusive an approximation for beam problems. This result, however, is in agreement with theoretical expectations.

  17. Results for local control and functional outcome after linac-based image-guided stereotactic radiosurgery in 190 patients with vestibular schwannoma

    PubMed Central

    Badakhshi, Harun; Graf, Reinhold; Böhmer, Dirk; Synowitz, Michael; Wiener, Edzard; Budach, Volker

    2014-01-01

    Background We assessed local control (LC) and functional outcome after linac-based stereotactic radiosurgery (SRS) for vestibular schwannoma (VS). Methods Between 1998 and 2008, 190 patients with VS were treated with SRS. All patients had tumors <2 cm diameter. Patients received 13.5 Gy prescribed to the 80th isodose at the tumor margin. The primary endpoint was LC. Secondary endpoints were symptomatic control and morbidity. Results Median follow-up was 40 months. LC was achieved in 88% of patients. There were no acute reactions exceeding Grade I. Trigeminal nerve dysfunction was present in 21.6% (n = 41) prior to SRS. After treatment, 85% (n = 155) had no change, 4.4,% (n = 8) had a relief of symptoms, 10.4% (n = 19) had new symptoms. Facial nerve dysfunction was present in some patients prior to treatment, e.g. paresis (12.6%; n = 24) and dysgeusia (0.5%; n = 1). After treatment 1.1% (n = 2) reported improvement and 6.1% (n = 11) experienced new symptoms. Hearing problems before SRS were present in 69.5% of patients (n = 132). After treatment, 62.6% (n = 144) had no change, 10.4% (n = 19) experienced improvement and 26.9% (n = 49) became hearing impaired. Conclusion This series of SRS for small VS provided similar LC rates to microsurgery; thus, it is effective as a non-invasive, image-guided procedure. The functional outcomes observed indicate the safety and effectiveness of linac-based SRS. Patients may now be informed of the clinical equivalence of SRS to microsurgery. PMID:23979079

  18. SU-E-T-514: Simultaneously Determination of Radiation Isocentricity of Gantry, Collimator and Couch Using a Commercial Three-Dimensional Dosimetry QA Apparatus

    SciTech Connect

    Yan, S; Song, H; Wu, Q

    2014-06-01

    Purpose: Radiation isocentricity is an important benchmark for a LINAC and is typically determined by 3 separate film star-shots. We developed a technique to simultaneously determine the radiation isocenter of gantry, collimator and couch with a commercial 3D QA apparatus. Methods: The ArcCHECK from SunNuclear was used on two LINACs. It was aligned with room lasers. For gantry rotation, collimator and couch were set to zero and gantry was placed to 0, 49, 213 and 311 degrees. Similarly, a set of collimator/couch angles were chosen with the other two axes at neutral positions. The measured dose matrices were analyzed by an in-house MATLAB program. For each shot, the central axis was determined by computing the FWHM of the diode arrays. The largest inscribed circle from these central axis lines was used to determine isocenter: the radius as the benchmark of isocentricity and the coordinates of the center as the discrepancy of radiation isocenter to the origin defined by lasers. To validate the method, the couch was shifted by ~5 mm in all three directions and measurements were repeated. Results: The radius of the largest inscribed circle for gantry, collimator and couch are (0.3, 0.5, 0.2) mm for one LINAC and (0.2, 0.3, 0.1) mm for the other, in agreement with the film star-shots at annual QA. The discrepancies of radiation isocenter are generally within 1 mm, except gantry rotation on one LINAC due to the drift of foot laser. The differences in positions detected are consistent with the intentional predefined shift. Conclusion: We have demonstrated a technique for the simultaneous measurement of gantry, collimator, and couch isocentricity with a set of carefully chosen irradiation parameters based on the specific construction geometry of the 3D detector ArcCheck. This can replace the standard film star-shots. The future work includes improving operation efficiency.

  19. ITS version 5.0 : the integrated TIGER series of coupled electron/photon Monte Carlo transport codes.

    SciTech Connect

    Franke, Brian Claude; Kensek, Ronald Patrick; Laub, Thomas William

    2004-06-01

    ITS is a powerful and user-friendly software package permitting state of the art Monte Carlo solution of linear time-independent couple electron/photon radiation transport problems, with or without the presence of macroscopic electric and magnetic fields of arbitrary spatial dependence. Our goal has been to simultaneously maximize operational simplicity and physical accuracy. Through a set of preprocessor directives, the user selects one of the many ITS codes. The ease with which the makefile system is applied combines with an input scheme based on order-independent descriptive keywords that makes maximum use of defaults and internal error checking to provide experimentalists and theorists alike with a method for the routine but rigorous solution of sophisticated radiation transport problems. Physical rigor is provided by employing accurate cross sections, sampling distributions, and physical models for describing the production and transport of the electron/photon cascade from 1.0 GeV down to 1.0 keV. The availability of source code permits the more sophisticated user to tailor the codes to specific applications and to extend the capabilities of the codes to more complex applications. Version 5.0, the latest version of ITS, contains (1) improvements to the ITS 3.0 continuous-energy codes, (2)multigroup codes with adjoint transport capabilities, and (3) parallel implementations of all ITS codes. Moreover the general user friendliness of the software has been enhanced through increased internal error checking and improved code portability.

  20. SU-E-T-567: A Three-Field Mono-Isocentric Inverse Treatment Planning Method for the Patients with Larger Breasts

    SciTech Connect

    Zhang, T; Marina, O; Chen, P; Teahan, M; Liu, Q; Benedetti, L

    2014-06-01

    Purpose: The purpose of this study is to develop a three-field monoisocentric inverse breast treatment planning technique without the use of half-beam block. Methods: Conventional three-field breast treatment with supraclavicular half-beam blocked requires two isocenters when the breast is too large to be contained within half-beam. The inferior border of the supraclavicular field and superior borders of the breast fields are matched on patient's skin with the light field. This method causes a large dose variation in the matching region due to daily setup uncertainties and requires a longer treatment setup time. We developed a three-field mono-isocentric planning method for the treatment of larger breasts. The three fields share the same isocenter located in the breast. Beam matching is achieved by rotating collimator, couch and gantry. Furthermore, we employed a mixed open-IMRT inverse optimization method to improve dose uniformity and coverage. Results: Perfect geometric beam matching was achieved by rotating couch, collimator and gantry together. Treatment setup time was significantly reduced without light-field matching during treatment deliveries. Inverse mixed open-IMRT optimization method achieved better dose uniformity and PTV coverage while keeping sufficient air flash to compensate setup and breast shape changes in daily treatments. Conclusion: By eliminating light field matching, the three-field mono-isocentric treatment method can significantly reduce setup time and uncertainty for large breast patients. Plan quality is further improved by inverse IMRT planning.

  1. A deterministic electron, photon, proton and heavy ion transport suite for the study of the Jovian moon Europa

    NASA Astrophysics Data System (ADS)

    Badavi, Francis F.; Blattnig, Steve R.; Atwell, William; Nealy, John E.; Norman, Ryan B.

    2011-02-01

    A Langley research center (LaRC) developed deterministic suite of radiation transport codes describing the propagation of electron, photon, proton and heavy ion in condensed media is used to simulate the exposure from the spectral distribution of the aforementioned particles in the Jovian radiation environment. Based on the measurements by the Galileo probe (1995-2003) heavy ion counter (HIC), the choice of trapped heavy ions is limited to carbon, oxygen and sulfur (COS). The deterministic particle transport suite consists of a coupled electron photon algorithm (CEPTRN) and a coupled light heavy ion algorithm (HZETRN). The primary purpose for the development of the transport suite is to provide a means to the spacecraft design community to rapidly perform numerous repetitive calculations essential for electron, photon, proton and heavy ion exposure assessment in a complex space structure. In this paper, the reference radiation environment of the Galilean satellite Europa is used as a representative boundary condition to show the capabilities of the transport suite. While the transport suite can directly access the output electron and proton spectra of the Jovian environment as generated by the jet propulsion laboratory (JPL) Galileo interim radiation electron (GIRE) model of 2003; for the sake of relevance to the upcoming Europa Jupiter system mission (EJSM), the JPL provided Europa mission fluence spectrum, is used to produce the corresponding depth dose curve in silicon behind a default aluminum shield of 100 mils (˜0.7 g/cm2). The transport suite can also accept a geometry describing ray traced thickness file from a computer aided design (CAD) package and calculate the total ionizing dose (TID) at a specific target point within the interior of the vehicle. In that regard, using a low fidelity CAD model of the Galileo probe generated by the authors, the transport suite was verified versus Monte Carlo (MC) simulation for orbits JOI-J35 of the Galileo probe

  2. Silicon/III-V laser with super-compact diffraction grating for WDM applications in electronic-photonic integrated circuits.

    PubMed

    Wang, Yadong; Wei, Yongqiang; Huang, Yingyan; Tu, Yongming; Ng, Doris; Lee, Cheewei; Zheng, Yunan; Liu, Boyang; Ho, Seng-Tiong

    2011-01-31

    We have demonstrated a heterogeneously integrated III-V-on-Silicon laser based on an ultra-large-angle super-compact grating (SCG). The SCG enables single-wavelength operation due to its high-spectral-resolution aberration-free design, enabling wavelength division multiplexing (WDM) applications in Electronic-Photonic Integrated Circuits (EPICs). The SCG based Si/III-V laser is realized by fabricating the SCG on silicon-on-insulator (SOI) substrate. Optical gain is provided by electrically pumped heterogeneous integrated III-V material on silicon. Single-wavelength lasing at 1550 nm with an output power of over 2 mW and a lasing threshold of around 150 mA were achieved. PMID:21369017

  3. SU-E-T-355: A Comparative Study of Robotic and Linac-Based Stereotactitc Body Radiation Therapy for Lumbar Spinal Tumors

    SciTech Connect

    Bossart, E; Monterroso, M; Couto, M; Ly, B; Mihaylov, I

    2014-06-01

    Purpose: Dosimetrically compare CyberKnife (CK) and linac-based (LB) stereotactic body radiotherapy (SBRT) plans for lumbar spine. Methods: Ten patient plans with lumbar spine tumors treated with CK were selected and retrospectively optimized using three techniques: CK, volumetric modulated arc (VMAT, three arcs), and 9-field-intensity modulated radiotherapy (IMRT). For the LB plans, the target volume was expanded by 1mm to accommodate additional uncertainty in patient positioning. All plans were optimized to a prescription dose of 27Gy in 3 fractions covering 90% of the PTV. If the dose constraints to the cauda equina (cauda) were not met, the prescription dose was lowered to 24Gy. Parameters evaluated included Paddick Conformity-Index (CI) and Gradient-Index (GI). A two-tailed paired t-test was used to establish statistically significant differences in cauda doses. Results: Target volumes for LB plans were on average 38% larger. In terms of the indices, the closer the index values to unity the steeper the dose falloff and the higher the dose conformity to the target. The results showed that LB plans were in general statistically superior to CK plans. The IMRT plan showed the best average gradient index of 2.995, with VMAT and CK GI values of 3.699 and 5.476, respectively. Similarly, the same trend occurs with the average CI results: 0.821, 0.814, and 0.758, corresponding to IMRT, VMAT, and CK. Notably, in one CK plan the target dose was reduced to 24Gy to meet cauda constraints. Additionally, there was a statistically significant dose difference for the cauda between the CK and LB plans. Conclusion: This study demonstrates that LB plans for lumbar spine SBRT can be as effective or even better than CK plans. Despite the expansion of the target volume, the LB plans did not demonstrate dosimetric inferiority. The LB plans Resultin 2-to-3 fold decrease of treatment time.

  4. Development of a GPU-based Monte Carlo dose calculation code for coupled electron-photon transport.

    PubMed

    Jia, Xun; Gu, Xuejun; Sempau, Josep; Choi, Dongju; Majumdar, Amitava; Jiang, Steve B

    2010-06-01

    Monte Carlo simulation is the most accurate method for absorbed dose calculations in radiotherapy. Its efficiency still requires improvement for routine clinical applications, especially for online adaptive radiotherapy. In this paper, we report our recent development on a GPU-based Monte Carlo dose calculation code for coupled electron-photon transport. We have implemented the dose planning method (DPM) Monte Carlo dose calculation package (Sempau et al 2000 Phys. Med. Biol. 45 2263-91) on the GPU architecture under the CUDA platform. The implementation has been tested with respect to the original sequential DPM code on the CPU in phantoms with water-lung-water or water-bone-water slab geometry. A 20 MeV mono-energetic electron point source or a 6 MV photon point source is used in our validation. The results demonstrate adequate accuracy of our GPU implementation for both electron and photon beams in the radiotherapy energy range. Speed-up factors of about 5.0-6.6 times have been observed, using an NVIDIA Tesla C1060 GPU card against a 2.27 GHz Intel Xeon CPU processor. PMID:20463376

  5. Spectral broadening and electron-photon coupling in III-V infrared detectors of low dimensional quantum confined system

    NASA Astrophysics Data System (ADS)

    Joy, Soumitra R.; Mohammedy, Farseem M.

    2016-05-01

    Present work explores the mid-IR photodetection mechanism in III-V quantum confined system in twofold ways. Firstly, it models the extent of spectral linewidth broadening of photo-detector. Secondly, it investigates whether a strong perturbation of light can modulate the electronic bandstructure. Photo-absorption mechanism in the detector correlated to reduced carrier lifetime in ground state leading to homogeneous spectral widening is calculated. Besides, contribution of non-uniform size and composition of quantum dots towards spectral broadening is modeled in order to get the envelop of inhomogeneously broadened photocurrent spectrum. Our model generates photocurrent spectrum with 1.4 μm broadening centered at 3.5 μm at 77 K for a DWELL-IP, which agrees with the experimental result. The calculated photocurrent spectral width of 1.3 μm for GaAs/AlGaAs Quantum Well (QW) centered at 8.31 μm at 77 K also supports experimental data. In addition, our calculation reveals the emergence of a broad resonant peak in the spectrum of QW-IP in far infrared region (20-50 μm) as the photon volume density increases up to 0.1% of carrier density inside the active region. We introduce a hybrid density-of-states for strongly coupled electron-photon system to explain both mid and far IR peak.

  6. Importance of point-by-point back projection correction for isocentric motion in digital breast tomosynthesis: Relevance to morphology of structures such as microcalcifications

    SciTech Connect

    Chen Ying; Lo, Joseph Y.; Dobbins, James T. III

    2007-10-15

    Digital breast tomosynthesis is a three-dimensional imaging technique that provides an arbitrary set of reconstruction planes in the breast from a limited-angle series of projection images acquired while the x-ray tube moves. Traditional shift-and-add (SAA) tomosynthesis reconstruction is a common mathematical method to line up each projection image based on its shifting amount to generate reconstruction slices. With parallel-path geometry of tube motion, the path of the tube lies in a plane parallel to the plane of the detector. The traditional SAA algorithm gives shift amounts for each projection image calculated only along the direction of x-ray tube movement. However, with the partial isocentric motion of the x-ray tube in breast tomosynthesis, small objects such as microcalcifications appear blurred (for instance, about 1-4 pixels in blur for a microcalcification in a human breast) in traditional SAA images in the direction perpendicular to the direction of tube motion. Some digital breast tomosynthesis algorithms reported in the literature utilize a traditional one-dimensional SAA method that is not wholly suitable for isocentric motion. In this paper, a point-by-point back projection (BP) method is described and compared with traditional SAA for the important clinical task of evaluating morphology of small objects such as microcalcifications. Impulse responses at different three-dimensional locations with five different combinations of imaging acquisition parameters were investigated. Reconstruction images of microcalcifications in a human subject were also evaluated. Results showed that with traditional SAA and 45 deg. view angle of tube movement with respect to the detector, at the same height above the detector, the in-plane blur artifacts were obvious for objects farther away from x-ray source. In a human subject, the appearance of calcifications was blurred in the direction orthogonal to the tube motion with traditional SAA. With point-by-point BP, the

  7. Dosimetric comparison of Linac-based (BrainLAB®) and robotic radiosurgery (CyberKnife ®) stereotactic system plans for acoustic schwannoma.

    PubMed

    Dutta, Debnarayan; Balaji Subramanian, S; Murli, V; Sudahar, H; Gopalakrishna Kurup, P G; Potharaju, Mahadev

    2012-02-01

    A dosimetric comparison of linear accelerator (LA)-based (BrainLAB) and robotic radiosurgery (RS) (CyberKnife) systems for acoustic schwannoma (Acoustic neuroma, AN) was carried out. Seven patients with radiologically confirmed unilateral AN were planned with both an LA-based (BrainLAB) and robotic RS (CyberKnife) system using the same computed tomography (CT) dataset and contours. Gross tumour volume (GTV) was contoured on post-contrast magnetic resonance imaging (MRI) scan [planning target volume (PTV) margin 2 mm]. Planning and calculation were done with appropriate calculation algorithms. The prescribed isodose in both systems was considered adequate to cover at least 95% of the contoured target. Plan evaluations were done by examining the target coverage by the prescribed isodose line, and high- and low-dose volumes. Isodose plans and dose volume histograms generated by the two systems were compared. There was no statistically significant difference between the contoured volumes between the systems. Tumour volumes ranged from 380 to 3,100 mm(3). Dose prescription was 13-15 Gy in single fraction (median prescribed isodose 85%). There were no significant differences in conformity index (CI) (0.53 versus 0.58; P = 0.225), maximum brainstem dose (4.9 versus 4.7 Gy; P = 0.935), 2.5-Gy volume (39.9 versus 52.3 cc; P = 0.238) or 5-Gy volume (11.8 versus 16.8 cc; P = 0.129) between BrainLAB and CyberKnife system plans. There were statistically significant differences in organs at risk (OAR) doses, such as mean cochlear dose (6.9 versus 5.4 Gy; P = 0.001), mean mesial temporal dose (2.6 versus 1.7 Gy; P = 0.07) and high-dose (10 Gy) volume (3.2 versus 5.2 cc; P = 0.017). AN patients planned with the CyberKnife system had superior OAR (cochlea and mesial temporal lobe) sparing compared with those planned with the Linac-based system. Further evaluation of these findings in prospective studies with clinical correlation will provide actual clinical benefit from the

  8. Monte Carlo electron-photon transport using GPUs as an accelerator: Results for a water-aluminum-water phantom

    SciTech Connect

    Su, L.; Du, X.; Liu, T.; Xu, X. G.

    2013-07-01

    An electron-photon coupled Monte Carlo code ARCHER - Accelerated Radiation-transport Computations in Heterogeneous Environments - is being developed at Rensselaer Polytechnic Institute as a software test bed for emerging heterogeneous high performance computers that utilize accelerators such as GPUs. In this paper, the preliminary results of code development and testing are presented. The electron transport in media was modeled using the class-II condensed history method. The electron energy considered ranges from a few hundred keV to 30 MeV. Moller scattering and bremsstrahlung processes above a preset energy were explicitly modeled. Energy loss below that threshold was accounted for using the Continuously Slowing Down Approximation (CSDA). Photon transport was dealt with using the delta tracking method. Photoelectric effect, Compton scattering and pair production were modeled. Voxelised geometry was supported. A serial ARHCHER-CPU was first written in C++. The code was then ported to the GPU platform using CUDA C. The hardware involved a desktop PC with an Intel Xeon X5660 CPU and six NVIDIA Tesla M2090 GPUs. ARHCHER was tested for a case of 20 MeV electron beam incident perpendicularly on a water-aluminum-water phantom. The depth and lateral dose profiles were found to agree with results obtained from well tested MC codes. Using six GPU cards, 6x10{sup 6} histories of electrons were simulated within 2 seconds. In comparison, the same case running the EGSnrc and MCNPX codes required 1645 seconds and 9213 seconds, respectively, on a CPU with a single core used. (authors)

  9. Comparison of Isocentric C-Arm 3-Dimensional Navigation and Conventional Fluoroscopy for Percutaneous Retrograde Screwing for Anterior Column Fracture of Acetabulum

    PubMed Central

    He, Jiliang; Tan, Guoqing; Zhou, Dongsheng; Sun, Liang; Li, Qinghu; Yang, Yongliang; Liu, Ping

    2016-01-01

    Abstract Percutaneous screw insertion for minimally displaced or reducible acetabular fracture using x-ray fluoroscopy and computer-assisted navigation system has been advocated by some authors. The purpose of this study was to compare intraoperative conditions and clinical results between isocentric C-arm 3-dimensional (Iso-C 3D) fluoroscopy and conventional fluoroscopy for percutaneous retrograde screwing of acetabular anterior column fracture. A prospective cohort study was conducted. A total of 22 patients were assigned to 2 different groups: 10 patients in the Iso-C 3D navigation group and 12 patients in the conventional group. The operative time, fluoroscopic time, time of screw insertion, blood loss, and accuracy were analyzed between the 2 groups. There were significant differences in operative time, screw insertion time, fluoroscopy time, and mean blood loss between the 2 groups. Totally 2 of 12 (16.7%) screws were misplaced in the conventional fluoroscopy group, and all 10 screws were in safe zones in the navigation group. Percutaneous screw fixation using the Iso-C 3D computer-assisted navigation system significantly reduced the intraoperative fluoroscopy time and blood loss in percutaneous screwing for acetabular anterior column fracture. The Iso-C 3D computer-assisted navigation system provided a reliable and effective method for percutaneous screw insertion in acetabular anterior column fractures compared to conventional fluoroscopy. PMID:26765448

  10. Comparison of Isocentric C-Arm 3-Dimensional Navigation and Conventional Fluoroscopy for Percutaneous Retrograde Screwing for Anterior Column Fracture of Acetabulum: An Observational Study.

    PubMed

    He, Jiliang; Tan, Guoqing; Zhou, Dongsheng; Sun, Liang; Li, Qinghu; Yang, Yongliang; Liu, Ping

    2016-01-01

    Percutaneous screw insertion for minimally displaced or reducible acetabular fracture using x-ray fluoroscopy and computer-assisted navigation system has been advocated by some authors. The purpose of this study was to compare intraoperative conditions and clinical results between isocentric C-arm 3-dimensional (Iso-C 3D) fluoroscopy and conventional fluoroscopy for percutaneous retrograde screwing of acetabular anterior column fracture.A prospective cohort study was conducted. A total of 22 patients were assigned to 2 different groups: 10 patients in the Iso-C 3D navigation group and 12 patients in the conventional group. The operative time, fluoroscopic time, time of screw insertion, blood loss, and accuracy were analyzed between the 2 groups.There were significant differences in operative time, screw insertion time, fluoroscopy time, and mean blood loss between the 2 groups. Totally 2 of 12 (16.7%) screws were misplaced in the conventional fluoroscopy group, and all 10 screws were in safe zones in the navigation group. Percutaneous screw fixation using the Iso-C 3D computer-assisted navigation system significantly reduced the intraoperative fluoroscopy time and blood loss in percutaneous screwing for acetabular anterior column fracture.The Iso-C 3D computer-assisted navigation system provided a reliable and effective method for percutaneous screw insertion in acetabular anterior column fractures compared to conventional fluoroscopy. PMID:26765448

  11. A Deterministic Electron, Photon, Proton and Heavy Ion Radiation Transport Suite for the Study of the Jovian System

    NASA Technical Reports Server (NTRS)

    Norman, Ryan B.; Badavi, Francis F.; Blattnig, Steve R.; Atwell, William

    2011-01-01

    A deterministic suite of radiation transport codes, developed at NASA Langley Research Center (LaRC), which describe the transport of electrons, photons, protons, and heavy ions in condensed media is used to simulate exposures from spectral distributions typical of electrons, protons and carbon-oxygen-sulfur (C-O-S) trapped heavy ions in the Jovian radiation environment. The particle transport suite consists of a coupled electron and photon deterministic transport algorithm (CEPTRN) and a coupled light particle and heavy ion deterministic transport algorithm (HZETRN). The primary purpose for the development of the transport suite is to provide a means for the spacecraft design community to rapidly perform numerous repetitive calculations essential for electron, proton and heavy ion radiation exposure assessments in complex space structures. In this paper, the radiation environment of the Galilean satellite Europa is used as a representative boundary condition to show the capabilities of the transport suite. While the transport suite can directly access the output electron spectra of the Jovian environment as generated by the Jet Propulsion Laboratory (JPL) Galileo Interim Radiation Electron (GIRE) model of 2003; for the sake of relevance to the upcoming Europa Jupiter System Mission (EJSM), the 105 days at Europa mission fluence energy spectra provided by JPL is used to produce the corresponding dose-depth curve in silicon behind an aluminum shield of 100 mils ( 0.7 g/sq cm). The transport suite can also accept ray-traced thickness files from a computer-aided design (CAD) package and calculate the total ionizing dose (TID) at a specific target point. In that regard, using a low-fidelity CAD model of the Galileo probe, the transport suite was verified by comparing with Monte Carlo (MC) simulations for orbits JOI--J35 of the Galileo extended mission (1996-2001). For the upcoming EJSM mission with a potential launch date of 2020, the transport suite is used to compute

  12. ITS version 5.0 :the integrated TIGER series of coupled electron/Photon monte carlo transport codes with CAD geometry.

    SciTech Connect

    Franke, Brian Claude; Kensek, Ronald Patrick; Laub, Thomas William

    2005-09-01

    ITS is a powerful and user-friendly software package permitting state-of-the-art Monte Carlo solution of linear time-independent coupled electron/photon radiation transport problems, with or without the presence of macroscopic electric and magnetic fields of arbitrary spatial dependence. Our goal has been to simultaneously maximize operational simplicity and physical accuracy. Through a set of preprocessor directives, the user selects one of the many ITS codes. The ease with which the makefile system is applied combines with an input scheme based on order-independent descriptive keywords that makes maximum use of defaults and internal error checking to provide experimentalists and theorists alike with a method for the routine but rigorous solution of sophisticated radiation transport problems. Physical rigor is provided by employing accurate cross sections, sampling distributions, and physical models for describing the production and transport of the electron/photon cascade from 1.0 GeV down to 1.0 keV. The availability of source code permits the more sophisticated user to tailor the codes to specific applications and to extend the capabilities of the codes to more complex applications. Version 5.0, the latest version of ITS, contains (1) improvements to the ITS 3.0 continuous-energy codes, (2) multigroup codes with adjoint transport capabilities, (3) parallel implementations of all ITS codes, (4) a general purpose geometry engine for linking with CAD or other geometry formats, and (5) the Cholla facet geometry library. Moreover, the general user friendliness of the software has been enhanced through increased internal error checking and improved code portability.

  13. Development of high intensity laser-electron photon beams up to 2.9 GeV at the SPring-8 LEPS beamline

    NASA Astrophysics Data System (ADS)

    Muramatsu, N.; Kon, Y.; Daté, S.; Ohashi, Y.; Akimune, H.; Chen, J. Y.; Fujiwara, M.; Hasegawa, S.; Hotta, T.; Ishikawa, T.; Iwata, T.; Kato, Y.; Kohri, H.; Matsumura, T.; Mibe, T.; Miyachi, Y.; Morino, Y.; Nakano, T.; Nakatsugawa, Y.; Ohkuma, H.; Ohta, T.; Oka, M.; Sawada, T.; Wakai, A.; Yonehara, K.; Yoon, C. J.; Yorita, T.; Yosoi, M.

    2014-02-01

    A laser-Compton backscattering beam, which we call a 'Laser-Electron Photon' beam, was upgraded at the LEPS beamline of SPring-8. We accomplished the gains in backscattered photon beam intensities by factors of 1.5-1.8 with the injection of two adjacent laser beams or a higher power laser beam into the storage ring. The maximum energy of the photon beam was also extended from 2.4 GeV to 2.9 GeV with deep-ultraviolet lasers. The upgraded beams have been utilized for hadron photoproduction experiments at the LEPS beamline. Based on the developed methods, we plan the simultaneous injection of four high power laser beams at the LEPS2 beamline, which has been newly constructed at SPring-8. As a simulation result, we expect an order of magnitude higher intensities close to 107 s-1 and 106 s-1 for tagged photons up to 2.4 GeV and 2.9 GeV, respectively.

  14. Estimation of daily interfractional larynx residual setup error after isocentric alignment for head and neck radiotherapy: Quality-assurance implications for target volume and organ-at-risk margination using daily CT-on-rails imaging

    PubMed Central

    Baron, Charles A.; Awan, Musaddiq J.; Mohamed, Abdallah S. R.; Akel, Imad; Rosenthal, David I.; Gunn, G. Brandon; Garden, Adam S.; Dyer, Brandon A.; Court, Laurence; Sevak, Parag R; Kocak-Uzel, Esengul; Fuller, Clifton D.

    2016-01-01

    Larynx may alternatively serve as a target or organ-at-risk (OAR) in head and neck cancer (HNC) image-guided radiotherapy (IGRT). The objective of this study was to estimate IGRT parameters required for larynx positional error independent of isocentric alignment and suggest population–based compensatory margins. Ten HNC patients receiving radiotherapy (RT) with daily CT-on-rails imaging were assessed. Seven landmark points were placed on each daily scan. Taking the most superior anterior point of the C5 vertebra as a reference isocenter for each scan, residual displacement vectors to the other 6 points were calculated post-isocentric alignment. Subsequently, using the first scan as a reference, the magnitude of vector differences for all 6 points for all scans over the course of treatment were calculated. Residual systematic and random error, and the necessary compensatory CTV-to-PTV and OAR-to-PRV margins were calculated, using both observational cohort data and a bootstrap-resampled population estimator. The grand mean displacements for all anatomical points was 5.07mm, with mean systematic error of 1.1mm and mean random setup error of 2.63mm, while bootstrapped POIs grand mean displacement was 5.09mm, with mean systematic error of 1.23mm and mean random setup error of 2.61mm. Required margin for CTV-PTV expansion was 4.6mm for all cohort points, while the bootstrap estimator of the equivalent margin was 4.9mm. The calculated OAR-to-PRV expansion for the observed residual set-up error was 2.7mm, and bootstrap estimated expansion of 2.9mm. We conclude that the interfractional larynx setup error is a significant source of RT set-up/delivery error in HNC both when the larynx is considered as a CTV or OAR. We estimate the need for a uniform expansion of 5mm to compensate for set up error if the larynx is a target or 3mm if the larynx is an OAR when using a non-laryngeal bony isocenter. PMID:25679151

  15. LINAC-based transuranic waste characterization system

    SciTech Connect

    Schultz, F.J.; Womble, P.C.; Vourvopoulos, G.; Roberts, M.L.

    1994-12-31

    Remote-handled transuranic nuclear waste poses a particular challenge for assaying due to the high neutron and gamma ray background that emanates from the non-fissile, but highly radioactive material, contained with the waste. The utilization of a RFQ linac with a neutron flux has shown that, in principle, the differential die-away technique can reliably assay this special class of nuclear waste.

  16. Comments on a linac based beauty factory

    SciTech Connect

    Samuel Heifets; Geoffrey Krafft; C. McDowell; M. Fripp

    1990-02-01

    A consistent set of parameters is given for a B-factory based on collisions of an electron beam from a SRF linac with the positron beam in a storage ring. An optimized lattice, an impedance estimate, a study of beam stability, and a discussion of collisions with large disruption parameters are included.

  17. Enigmatic electrons, photons, and ``empty`` waves

    SciTech Connect

    MacGregor, M.H.

    1995-08-22

    A spectroscopic analysis is made of electrons and photons from the standpoint of physical realism. In this conceptual framework, moving particles are portrayed as localized entities which are surrounded by ``empty`` waves. A spectroscopic model for the electron Stands as a guide for a somewhat similar, but in essential respects radically different, model for the photon. This leads in turn to a model for the ``zeron``. the quantum of the empty wave. The properties of these quanta mandate new basis states, and hence an extension of our customary framework for dealing with them. The zeron wave field of a photon differs in one important respect from the standard formalism for an electromagnetic wave. The vacuum state emerges as more than just a passive bystander. Its polarization properties provide wave stabilization, particle probability distributions, and orbit quantization. Questions with regard to special relativity are discussed.

  18. FLUTE: A versatile linac-based THz source

    SciTech Connect

    Nasse, M. J.; Schuh, M.; Schwarz, M.; Naknaimueang, S.; Mathis, Y.-L.; Rossmanith, R.; Wesolowski, P.; Huttel, E.; Plech, A.; Schmelling, M.; Mueller, A.-S.

    2013-02-15

    A new compact versatile linear accelerator named FLUTE is currently being designed at the Karlsruhe Institute of Technology. This paper presents the status of this 42 MeV machine. It will be used to generate strong (several 100 MV/m) ultra-short ({approx}1 ps) THz pulses (up to {approx}4-25 THz) for photon science experiments, as well as to conduct a variety of accelerator studies. The latter range from comparing different coherent THz radiation generation schemes to compressing electron bunches and studying the electron beam stability. The bunch charge will cover a wide range ({approx}100 pC-3 nC). Later we plan to also produce ultra-short x-ray pulses from the electron bunches, which, for example, could then be combined for THz pump-x-ray probe experiments.

  19. FLUTE: a versatile linac-based THz source.

    PubMed

    Nasse, M J; Schuh, M; Naknaimueang, S; Schwarz, M; Plech, A; Mathis, Y-L; Rossmanith, R; Wesolowski, P; Huttel, E; Schmelling, M; Müller, A-S

    2013-02-01

    A new compact versatile linear accelerator named FLUTE is currently being designed at the Karlsruhe Institute of Technology. This paper presents the status of this 42 MeV machine. It will be used to generate strong (several 100 MV/m) ultra-short (~1 ps) THz pulses (up to ~4-25 THz) for photon science experiments, as well as to conduct a variety of accelerator studies. The latter range from comparing different coherent THz radiation generation schemes to compressing electron bunches and studying the electron beam stability. The bunch charge will cover a wide range (~100 pC-3 nC). Later we plan to also produce ultra-short x-ray pulses from the electron bunches, which, for example, could then be combined for THz pump-x-ray probe experiments. PMID:23464187

  20. Advances in Linac-Based Technology for Industrial Radiation Processing

    NASA Astrophysics Data System (ADS)

    McKeown, Joseph

    1997-04-01

    Experience with the Industrial Materials Processing Electron Linear Accelerator, IMPELA, over 30,000 hours of 50 kW operation is reported for three irradiators, two of which are in commercial service. Operations are sufficiently mature that research is now concentrated on split beams, photon conversion, dose monitoring, beam scanning, new shielding designs and QA controls. The efficacy of increasing the incident electron energy on bremsstrahlung converters to 7.5 MeV, as proposed by an IAEA committee, is examined experimentally on an IMPELA accelerator over the energy range 7 MeV to 11 MeV to evaluate conversion efficiency, activation of machine components, converter engineering and the activation of red meat. Above 8 MeV the radioactive isotopes ^38Cl and ^24Na, formed primarily by neutrons produced in a tantalum converter, were clearly identified in the meat, while above 10.5 MeV the radiation from ^13N becomes dominant. Implications for the practicality of processing other high density products are discussed.

  1. FLUTE: A versatile linac-based THz source

    NASA Astrophysics Data System (ADS)

    Nasse, M. J.; Schuh, M.; Naknaimueang, S.; Schwarz, M.; Plech, A.; Mathis, Y.-L.; Rossmanith, R.; Wesolowski, P.; Huttel, E.; Schmelling, M.; Müller, A.-S.

    2013-02-01

    A new compact versatile linear accelerator named FLUTE is currently being designed at the Karlsruhe Institute of Technology. This paper presents the status of this 42 MeV machine. It will be used to generate strong (several 100 MV/m) ultra-short (˜1 ps) THz pulses (up to ˜4-25 THz) for photon science experiments, as well as to conduct a variety of accelerator studies. The latter range from comparing different coherent THz radiation generation schemes to compressing electron bunches and studying the electron beam stability. The bunch charge will cover a wide range (˜100 pC-3 nC). Later we plan to also produce ultra-short x-ray pulses from the electron bunches, which, for example, could then be combined for THz pump-x-ray probe experiments.

  2. Accurate eye center location through invariant isocentric patterns.

    PubMed

    Valenti, Roberto; Gevers, Theo

    2012-09-01

    Locating the center of the eyes allows for valuable information to be captured and used in a wide range of applications. Accurate eye center location can be determined using commercial eye-gaze trackers, but additional constraints and expensive hardware make these existing solutions unattractive and impossible to use on standard (i.e., visible wavelength), low-resolution images of eyes. Systems based solely on appearance are proposed in the literature, but their accuracy does not allow us to accurately locate and distinguish eye centers movements in these low-resolution settings. Our aim is to bridge this gap by locating the center of the eye within the area of the pupil on low-resolution images taken from a webcam or a similar device. The proposed method makes use of isophote properties to gain invariance to linear lighting changes (contrast and brightness), to achieve in-plane rotational invariance, and to keep low-computational costs. To further gain scale invariance, the approach is applied to a scale space pyramid. In this paper, we extensively test our approach for its robustness to changes in illumination, head pose, scale, occlusion, and eye rotation. We demonstrate that our system can achieve a significant improvement in accuracy over state-of-the-art techniques for eye center location in standard low-resolution imagery. PMID:22813958

  3. Electronic-photonic integrated circuits on the CMOS platform

    NASA Astrophysics Data System (ADS)

    Kimerling, L. C.; Ahn, D.; Apsel, A. B.; Beals, M.; Carothers, D.; Chen, Y.-K.; Conway, T.; Gill, D. M.; Grove, M.; Hong, C.-Y.; Lipson, M.; Liu, J.; Michel, J.; Pan, D.; Patel, S. S.; Pomerene, A. T.; Rasras, M.; Sparacin, D. K.; Tu, K.-Y.; White, A. E.; Wong, C. W.

    2006-02-01

    The optical components industry stands at the threshold of a major expansion that will restructure its business processes and sustain its profitability for the next three decades. This growth will establish a cost effective platform for the partitioning of electronic and photonic functionality to extend the processing power of integrated circuits. BAE Systems, Lucent Technologies, Massachusetts Institute of Technology, and Applied Wave Research are participating in a high payoff research and development program for the Microsystems Technology Office (MTO) of DARPA. The goal of the program is the development of technologies and design tools necessary to fabricate an application-specific, electronicphotonic integrated circuit (AS-EPIC). As part of the development of this demonstration platform we are exploring selected functions normally associated with the front end of mixed signal receivers such as modulation, detection, and filtering. The chip will be fabricated in the BAE Systems CMOS foundry and at MIT's Microphotonics Center. We will present the latest results on the performance of multi-layer deposited High Index Contrast Waveguides, CMOS compatible modulators and detectors, and optical filter slices. These advances will be discussed in the context of the Communications Technology Roadmap that was recently released by the MIT Microphotonics Center Industry Consortium.

  4. Electron-photon coupling in mesoscopic quantum electrodynamics

    NASA Astrophysics Data System (ADS)

    Cottet, A.; Kontos, T.; Douçot, B.

    2015-05-01

    Understanding the interaction between cavity photons and electronic nanocircuits is crucial for the development of mesoscopic quantum electrodynamics (QED). One has to combine ingredients from atomic cavity QED, such as orbital degrees of freedom, with tunneling physics and strong cavity field inhomogeneities, specific to superconducting circuit QED. It is therefore necessary to introduce a formalism which bridges between these two domains. We develop a general method based on a photonic pseudopotential to describe the electric coupling between electrons in a nanocircuit and cavity photons. In this picture, photons can induce simultaneously orbital energy shifts, tunneling, and local orbital transitions. We study in detail the elementary example of a single quantum dot with a single normal metal reservoir, coupled to a cavity. Photon-induced tunneling terms lead to a nonuniversal relation between the cavity frequency pull and the damping pull. Our formalism can also be applied to multiple quantum dot circuits, molecular circuits, quantum point contacts, metallic tunnel junctions, and superconducting nanostructures enclosing Andreev bound states or Majorana bound states, for instance.

  5. Electron, photons, and molecules: Storing energy from light

    SciTech Connect

    Miller, J.R.

    1996-09-01

    Molecular charge separation has important potential for photochemical energy storage. Its efficiency can be enhanced by principals which maximize the rates of the electron transfer steps which separate charge and minimize those which recombine high-energy charge pairs to lose stored energy. Dramatic scientific progress in understanding these principals has occurred since the founding of DOE and its predecessor agency ERDA. While additional knowledge in needed in broad areas of molecular electron transfer, some key areas of knowledge hold particular promise for the possibility of moving this area from science toward technology capable of contributing to the nation`s energy economy.

  6. Electron-Photon Coincidence Calibration Of Photon Detectors

    NASA Technical Reports Server (NTRS)

    Srivastava, Santosh K.

    1988-01-01

    Absolute and relative detector efficiencies measured. Apparatus uses coincidence-counting techniques to measure efficiency of ultraviolet or vacuum ultraviolet detector at very low radiation intensity. Crossed electron and atomic beams generate photons used to calibrate photon detector. Pulses from electron counter and photon detector(s) processed by standard coincidence-counting techniques. Used to calibrate other detectors or make absolute measurements of incident photon fluxes.

  7. LDRD project 151362 : low energy electron-photon transport.

    SciTech Connect

    Kensek, Ronald Patrick; Hjalmarson, Harold Paul; Magyar, Rudolph J.; Bondi, Robert James; Crawford, Martin James

    2013-09-01

    At sufficiently high energies, the wavelengths of electrons and photons are short enough to only interact with one atom at time, leading to the popular %E2%80%9Cindependent-atom approximation%E2%80%9D. We attempted to incorporate atomic structure in the generation of cross sections (which embody the modeled physics) to improve transport at lower energies. We document our successes and failures. This was a three-year LDRD project. The core team consisted of a radiation-transport expert, a solid-state physicist, and two DFT experts.

  8. Comparative analyses of linac and Gamma Knife radiosurgery for trigeminal neuralgia treatments

    NASA Astrophysics Data System (ADS)

    Ma, L.; Kwok, Y.; Chin, L. S.; Yu, C.; Regine, W. F.

    2005-11-01

    Dedicated linac-based radiosurgery has been reported for trigeminal neuralgia treatments. In this study, we investigated the dose fall-off characteristics and setup error tolerance of linac-based radiosurgery as compared with standard Gamma Knife radiosurgery. In order to minimize the errors from different treatment planning calculations, consistent imaging registration, dose calculation and dose volume analysis methods were developed and implemented for both Gamma Knife and linac-based treatments. Intra-arc setup errors were incorporated into the treatment planning process of linac-based deliveries. The effects of intra-arc setup errors with increasing number of arcs were studied and benchmarked against Gamma Knife deliveries with and without plugging patterns. Our studies found equivalent dose fall-off properties between Gamma Knife and linac-based radiosurgery given a sufficient number of arcs (>7) and small intra-arc errors (<0.5 mm) were satisfied for linac-based deliveries. Increasing the number of arcs significantly decreased the variations in the dose fall-off curve at the low isodose region (e.g. from 40% to 10%) and also improved dose uniformity at the high isodose region (e.g. from 70% to 90%). As the number of arcs increased, the effects of intra-arc setup errors on the dose fall-off curves decreased. Increasing the number of arcs also reduced the integral dose to the distal normal brain tissues. In conclusion, linac-based radiosurgery produces equivalent dose fall-off characteristics to Gamma Knife radiosurgery with a high number of arcs. However, one must note the increased treatment time for a large number of arcs and isocentre accuracies.

  9. Conformity of LINAC-Based Stereotactic Radiosurgery Using Dynamic Conformal Arcs and Micro-Multileaf Collimator

    SciTech Connect

    Hazard, Lisa J. Wang, Brian; Skidmore, Thomas B.; Chern, Shyh-Shi; Salter, Bill J.; Jensen, Randy L.; Shrieve, Dennis C.

    2009-02-01

    Purpose: To assess the conformity of dynamic conformal arc linear accelerator-based stereotactic radiosurgery and to describe a standardized method of isodose surface (IDS) selection. Methods and Materials: In 174 targets, the conformity index (CI) at the prescription IDS used for treatment was calculated as CI = (PIV/PVTV)/(PVTV/TV), where TV is the target volume, PIV (prescription isodose volume) is the total volume encompassed by the prescription IDS, and PVTV is the TV encompassed by the IDS. In addition, a 'standardized' prescription IDS (sIDS) was chosen according to the following criteria: 95% of the TV was encompassed by the PIV and 99% of TV was covered by 95% of the prescription dose. The CIs at the sIDS were also calculated. Results: The median CI at the prescription IDS and sIDS was 1.63 and 1.47, respectively (p < 0.001). In 132 of 174 cases, the volume of normal tissue in the PIV was reduced by the prescription to the sIDS compared with the prescription IDS, in 20 cases it remained unchanged, and in 22 cases it was increased. Conclusion: The CIs obtained with linear accelerator-based stereotactic radiosurgery are comparable to those previously reported for gamma knife stereotactic radiosurgery. Using a uniform method to select the sIDS, adequate target coverage was usually achievable with prescription to an IDS greater than that chosen by the treating physician (prescription IDS), providing sparing of normal tissue. Thus, the sIDS might aid physicians in identifying a prescription IDS that balances coverage and conformity.

  10. Feasibility study for a recirculating linac-based facility for femtosecond dynamics

    SciTech Connect

    Corlett, J.N.; Barry, W.; Barletta, W.A.; Byrd, J.M.; DeSantis, S.; Doolittle, L.; Fawley, W.; Green, M.A.; Hartman, N.; Heimann, P.; Kairan, D.; Kujawski, E.; Li, D.; Lidia, S.; Luft, P.; McClure, R.; Parmigiani, F.; Petroff, Y.; Pirkl, W.; Placidi, M.; Reavill, D.; Reichel, I.; Rimmer, R.A.; Ratti, A.; Robinson, K.E.; Sannibale, F.; Schoenlein, R.; Staples, J.; Tanabe, J.; Truchlikova, D.; Wan, W.; Wang, S.; Wells, R.; Wolski, A.; Zholents, A.

    2002-12-21

    LBNL is pursuing design studies and the scientific program for a facility dedicated to the production of x-ray pulses with ultra-short time duration, for application in dynamical studies of processes in physics, biology, and chemistry. The proposed x-ray facility has the short x-ray pulse length ({approx}60 fs FWHM) necessary to study very fast dynamics, high flux (up to approximately 10E11 photons/sec/0.1 percentBW) to study weakly scattering systems, and tuneability over 1-12 keV photon energy. The hard x-ray photon production section of the machine accommodates seven 2-m long undulators. Design studies for longer wavelength sources, using high-gain harmonic generation, are in progress. The x-ray pulse repetition rate of 10 kHz is matched to studies of dynamical processes (initiated by ultra-short laser pulses) that typically have a long recovery time or are not generally cyclic or reversible and need time to allow relaxation, replacement, or flow of the sample. The technique for producing ultra-short x-ray pulses uses relatively long electron bunches to minimize high-peak-current collective effects, and the ultimate x-ray duration is achieved by a combination of bunch manipulation and optical compression. Synchronization of x-ray pulses to sample excitation signals is expected to be of order 50 - 100 fs. Techniques for making use of the recirculating geometry to provide beam-based signals from early passes through the machine are being studied.

  11. Optimal focusing for a linac-based hard x-ray source

    SciTech Connect

    Liu, C.; Krafft, G.; Talman, R.

    2011-03-28

    In spite of having a small average beam current limit, a linac can have features that make it attractive as an x-ray source: high energy, ultralow emittance and energy spread, and flexible beamline optics. Unlike a storage ring, in which an (undulator) radiation source is necessarily short and positioned at an electron beam waist, in a linac the undulator can be long and the electron beam can be adjusted to have a (virtual) waist far downstream toward the x-ray target. Using a planned CEBAF beamline as an example, this paper shows that a factor of 2000 in beam current can be overcome to produce a monochromatic hard x-ray source comparable with, or even exceeding, the performance of an x-ray line at a third generation storage ring. Optimal electron beam focusing conditions for x-ray flux density and brilliance are derived, and are verified by simulations using the SRW code.

  12. SU-E-T-536: LINAC-Based Single Isocenter Frameless SRT for Brain Metastases

    SciTech Connect

    Liu, B; Zhang, L; Rigor, N; Kim, J

    2015-06-15

    Purpose: Single-isocenter Stereotactic Radiotherapy of multiple brain metastases with Varian 21 IX LINAC, using Aktina Pinpoint system for patient setup. Methods: In 2014, five single-isocenter RapidArc SRT plans were delivered to five patients with 2 to 8 brain metastases using Varian 21 IX. Aktina Pinpoint system was used for setup and 2mm PTV margin were used. CBCT was acquired before and after the beam delivery. The prescription is 2100 cGy in 3 fractions. Eclipse planning system was used for treatment planning. Depending on the number of metastases and their locations, 1 to 5 coplanar or non coplanar arcs were used. Typically, 2 or 3 arcs are used. IMRT QAs were performed by comparing an A1SL ion chamber point dose measurement in solid water phantom to point dose of the plan; also, based on EPID measurement, 3D spatial dose was calculated using DosimetryCheck software package from MathResolutions Inc. The EPID system has an active area of 40cm by 30cm with 1024 by 768 photodiodes, which corresponds to a resolution of 0.4mm by 0.4mm pixel dimension. Results: for all the plans, at least 95% PTV coverage was achieved for full prescription dose, with plan normalization > 75%. RTOG conformity indices are less than 1.1 and Paddick gradient indices are less than 4.5. The distance from prescription IDL to 50% IDL increases as the number of metastases increases, and it ranges from 0.6mm to 0.8mm. Treatment time varies from 10mins to 30mins, depending on the number of arcs and if the arcs are coplanar. IMRT QA shows that the ion chamber measurement agree with the eclipse calculation within 3%, and 95% of the points passed Gamma, using 3% dose difference and 3mm DTA Conclusion: High quality single isocenter RapidArc SRT plan can be optimized and accurately delivered using Eclipse and Varian 21IX.

  13. LUX - A recirculating linac-based ultrafast X-ray source

    SciTech Connect

    Corlett, J.N.; Barletta, W.A.; DeSantis, S.; Doolittle, L.; Fawley, W.M.; Green, M.A.; Heimann, P.; Leone, S.R.; Lidia, S.; Li, D.; Parmigiani, F.; Ratti, A.; Robinson, K.; Schoenlein, R.; Staples, J.; Wan, W.; Wells, R.; Wilcox, R.; Wolski, A.; Zholents, A.

    2003-08-01

    We describe the design of a proposed source of ultra-fast synchrotron radiation x-ray pulses based on a recirculating superconducting linac, with an integrated array of ultrafast laser systems. The source produces x-ray pulses with duration of 10-50 fs at a 10 kHz repetition rate, with tunability from EUV to hard x-ray regimes, and optimized for the study of ultra-fast dynamics. A high-brightness rf photocathode provides electron bunches. An injector linac accelerates the beam to the 100 MeV range, and is followed by four passes through a 700 MeV recirculating linac. Ultrafast hard x-ray pulses are obtained by a combination of electron bunch manipulation, transverse temporal correlation of the electrons, and x-ray pulse compression. EUV and soft x-ray pulses as short as 10 fs are generated in a harmonic-cascade free electron laser scheme.

  14. LUX - a recirculating linac-based facility for ultrafast X-ray science

    SciTech Connect

    Corlett, J.N.; Barletta, W.A.; DeSantis, S.; Doolittle, L.; Fawley, W.M.; Heimann, P.; Leone, S.; Lidia, S.; Li, D.; Penn, G.; Ratti, A.; Reinsch, M.; Schoenlein, R.; Staples, J.; Stover, G.; Virostek, S.; Wan, W.; Wells, R.; Wilcox, R.; Wolski, A.; Wurtele, J.; Zholents, A.

    2004-06-29

    We present recent developments in design concepts for LUX - a source of ultra-short synchrotron radiation pulses based on a recirculating superconducting linac. The source produces high-flux x-ray pulses with duration of 100 fs or less at a 10 kHz repetition rate, optimized for the study of ultra-fast dynamics across many fields of science [1]. Cascaded harmonic generation in free-electron lasers (FEL's) produces coherent radiation in the VUV-soft x-ray regime, and a specialized technique is used to compress spontaneous emission for ultra-short-pulse photon production in the 1-10 keV range. High-brightness electron bunches of 2-3 mm-mrad emittance at 1 nC charge in 30 ps duration are produced in an rf photocathode gun and compressed to 3 ps duration following an injector linac, and recirculated three times through a 1 GeV main linac. In each return path, independently tunable harmonic cascades are inserted to produce seeded FEL radiation in selected photon energy ranges from approximately 20 eV with a single stage of harmonic generation, to 1 keV with a four-stage cascade. The lattice is designed to minimize emittance growth from effects such as coherent synchrotron radiation (CSR), and resistive wall wakefields. Timing jitter between pump lasers and x-ray pulses is minimized by use of a stable optical master oscillator, distributing timing signals over actively stabilized fiber-optic, phase-locking all lasers to the master oscillator, and generating all rf signals from the master oscillator. We describe technical developments including techniques for minimizing power dissipation in a high repetition rate rf photocathode gun, beam dynamics in two injector configurations, independently tunable beamlines for VUV and soft x-ray production by cascaded harmonic generation, a fast kicker design, timing systems for providing synchronization between experimental pump lasers and the x-ray pulse, and beamline design for maintaining nm-scale density modulation.

  15. Feasibility study for linac-based intensity modulated total marrow irradiation.

    PubMed

    Wilkie, Joel R; Tiryaki, Hanifi; Smith, Brett D; Roeske, John C; Radosevich, James A; Aydogan, Bulent

    2008-12-01

    Total body irradiation (TBI) is used as a preconditioning regimen prior to bone marrow transplant for treatment of hematologic malignancies. During TBI, large volumes of normal tissue are irradiated, and this can lead to toxicities, most significantly in the lungs. Intensity modulated total marrow irradiation (IMTMI) may be able to reduce these toxicities by directly targeting the bone marrow while minimizing the dose to critical structures. The goal of this study was to assess the feasibility of IMTMI by following the planning and delivery process for a Rando phantom. A three isocenter technique was used to provide a full body plan for treatment on a linear accelerator. Thermoluminescent detectors (TLDs) were placed at 22 positions throughout the phantom to compare the delivered doses to the planned doses. Individual intensity modulated radiation therapy verification plans were delivered to a solid water phantom for the three isocenters, and doses measured from an ion chamber and film were compared to the planned doses. The treatment plan indicated that target coverage was achieved with this IMTMI technique, and that the doses to critical structures were reduced by 29%-65% compared to conventional TBI. TLD readings demonstrated accurate dose delivery, with an average difference of 3.5% from the calculated dose. Ion chamber readings for the verification plans were all within 3% of the expected dose, and film measurements showed accurate dose distributions. Results from this study suggest that IMTMI using the three isocenter technique can be accurately delivered and may result in substantial dose reductions to critical structures. PMID:19175118

  16. Investigation of Linac-Based Image-Guided Hypofractionated Prostate Radiotherapy

    SciTech Connect

    Pawlicki, Todd . E-mail: tpaw@stanford.edu; Kim, Gwe-Ya; Hsu, Annie; Cotrutz, Cristian; Boyer, Arthur L.; Xing Lei; King, Christopher R.; Luxton, Gary

    2007-07-01

    A hypofractionation treatment protocol for prostate cancer was initiated in our department in December 2003. The treatment regimen consists of a total dose of 36.25 Gy delivered at 7.25 Gy per fraction over 10 days. We discuss the rationale for such a prostate hypofractionation protocol and the need for frequent prostate imaging during treatment. The CyberKnife (Accuray Inc., Sunnyvale, CA), a linear accelerator mounted on a robotic arm, is currently being used as the radiation delivery device for this protocol, due to its incorporation of near real-time kV imaging of the prostate via 3 gold fiducial seeds. Recently introduced conventional linac kV imaging with intensity modulated planning and delivery may add a new option for these hypofractionated treatments. The purpose of this work is to investigate the use of intensity modulated radiotherapy (IMRT) and the Varian Trilogy Accelerator with on-board kV imaging (Varian Medical Systems Inc., Palo Alto, CA) for treatment of our hypofractionated prostate patients. The dose-volume histograms and dose statistics of 2 patients previously treated on the CyberKnife were compared to 7-field IMRT plans. A process of acquiring images to observe intrafraction prostate motion was achieved in an average time of about 1 minute and 40 seconds, and IMRT beam delivery takes about 40 seconds per field. A complete 7-field IMRT plan can therefore be imaged and delivered in 10 to 17 minutes. The Varian Trilogy Accelerator with on-board imaging and IMRT is well suited for image-guided hypofractionated prostate treatments. During this study, we have also uncovered opportunities for improvement of the on-board imaging hardware/software implementation that would further enhance performance in this regard.

  17. LUX — A Recirculating Linac-based Ultrafast X-ray Source

    NASA Astrophysics Data System (ADS)

    Corlett, J. N.; Barletta, W. A.; DeSantis, S.; Doolittle, L.; Fawley, W. M.; Green, M. A.; Heimann, P.; Leone, S. R.; Lidia, S.; Li, D.; Parmigiani, F.; Ratti, A.; Robinson, K.; Schoenlein, R.; Staples, J.; Wan, W.; Wells, R.; Wilcox, R.; Wolski, A.; Zholents, A.

    2004-05-01

    We describe the design of a proposed source of ultra-fast synchrotron radiation x-ray pulses based on a recirculating superconducting linac, with an integrated array of ultrafast laser systems. The source produces x-ray pulses with duration of 10-50 fs at a 10 kHz repetition rate, with tunability from EUV to hard x-ray regimes, and optimized for the study of ultra-fast dynamics. A high-brightness rf photocathode provides electron bunches. An injector linac accelerates the beam to the 100 MeV range, and is followed by four passes through a 700 MeV recirculating linac. Ultrafast hard x-ray pulses are obtained by a combination of electron bunch manipulation, transverse temporal correlation of the electrons, and x-ray pulse compression. EUV and soft x-ray pulses as short as 10 fs are generated in a harmonic-cascade free electron laser scheme. We describe the facility major systems and peformance.

  18. High Repetition Rate, LINAC-based Nuclear Resonance Fluorescence FY 2009 Final Report

    SciTech Connect

    Mathew Kinlaw; Scott Watson; James Johnson; Alan Hunt; Heather Seipel; Edward Reedy

    2009-10-01

    Nuclear Resonance Fluorescence (NRF), which is possible for nuclei with atomic numbers greater than helium (Z=2), occurs when a nuclear level is excited by resonant absorption of a photon and subsequently decays by reemission of a photon. The excited nuclear states can become readily populated, provided the incident photon’s energy is within the Doppler-broadened width of the energy level being excited. Utilizing continuous energy photon spectra, as is characteristic of a bremsstrahlung photon beam, as the inspection source, ensures that at least some fraction of the impinging beam will contribute to the population of the excited energy levels in the material of interest. Upon de-excitation, either to the ground state or to a lower-energy excited state, the emitted fluorescence photon’s energy will correspond to the energy difference between the excited state and the state to which it decays. As each isotope inherently contains unique nuclear energy levels, the NRF states for each isotope are also unique. By exploiting this phenomenon, NRF photon detection provides a well-defined signature for identifying the presence of individual nuclear species. This report summarizes the second year (Fiscal Year [FY] 2009) of a collaborative research effort between Idaho National Laboratory, Idaho State University’s Idaho Accelerator Center, and Pacific Northwest National Laboratory. This effort focused on continuing to assess and optimize NRF-based detection techniques utilizing a slightly modified, commercially available, pulsed medical electron accelerator.

  19. Development and Evaluation of Multiple Isocentric Volumetric Modulated Arc Therapy Technique for Craniospinal Axis Radiotherapy Planning

    SciTech Connect

    Lee, Young K.; Brooks, Corrinne J.; Bedford, James L.; Warrington, Alan P.; Saran, Frank H.

    2012-02-01

    Purpose: To develop and compare a volumetric modulated arc therapy (VMAT) technique with conventional radiotherapy for craniospinal irradiation with respect to improved dose conformity and homogeneity in the planning target volume (PTV) and to reduced dose to organs at risk (OAR). Methods and Materials: Conventional craniospinal axis radiotherapy plans of 5 patients were acquired. The median (range) length of the PTV was 58.9 (48.1-83.7) cm. The 6-MV VMAT plans were inversely planned with one isocenter near the base of the brain and the minimum number of isocenters required for the specified lengths of spine. The plans were optimized with high weighting for PTV coverage and low weighting for OAR sparing. Conformity and heterogeneity indices, dose-volume histograms, mean doses, and non-PTV integral doses from the two plans (prescription dose 23.4 Gy in 13 fractions) were compared. Results: The median (range) conformity index of VMAT was 1.22 (1.09-1.45), compared with 1.69 (1.44-2.67) for conventional plans (p = 0.04). The median (range) heterogeneity index was also lower for VMAT compared with conventional plans: 1.04 (1.03-1.07) vs. 1.12 (1.09-1.19), respectively (p = 0.04). A significant reduction of mean and maximum doses was observed in the heart, thyroid, esophagus, optic nerves, and eyes with VMAT when compared with conventional plans. A decrease in body V{sub 10Gy} was observed, but for 4 of 5 patients non-PTV integral dose was increased with VMAT when compared with the conventional plans. Conclusions: A VMAT technique to treat the craniospinal axis significantly reduces OAR dose, potentially leading to lower late organ toxicity. However, this is achieved at the expense of increased low-dose volumes, which is inherent to the technique, carrying a potentially increased risk of secondary malignancies.

  20. Robust Eye Center Localization through Face Alignment and Invariant Isocentric Patterns

    PubMed Central

    Teng, Dongdong; Chen, Dihu; Tan, Hongzhou

    2015-01-01

    The localization of eye centers is a very useful cue for numerous applications like face recognition, facial expression recognition, and the early screening of neurological pathologies. Several methods relying on available light for accurate eye-center localization have been exploited. However, despite the considerable improvements that eye-center localization systems have undergone in recent years, only few of these developments deal with the challenges posed by the profile (non-frontal face). In this paper, we first use the explicit shape regression method to obtain the rough location of the eye centers. Because this method extracts global information from the human face, it is robust against any changes in the eye region. We exploit this robustness and utilize it as a constraint. To locate the eye centers accurately, we employ isophote curvature features, the accuracy of which has been demonstrated in a previous study. By applying these features, we obtain a series of eye-center locations which are candidates for the actual position of the eye-center. Among these locations, the estimated locations which minimize the reconstruction error between the two methods mentioned above are taken as the closest approximation for the eye centers locations. Therefore, we combine explicit shape regression and isophote curvature feature analysis to achieve robustness and accuracy, respectively. In practical experiments, we use BioID and FERET datasets to test our approach to obtaining an accurate eye-center location while retaining robustness against changes in scale and pose. In addition, we apply our method to non-frontal faces to test its robustness and accuracy, which are essential in gaze estimation but have seldom been mentioned in previous works. Through extensive experimentation, we show that the proposed method can achieve a significant improvement in accuracy and robustness over state-of-the-art techniques, with our method ranking second in terms of accuracy. According to our implementation on a PC with a Xeon 2.5Ghz CPU, the frame rate of the eye tracking process can achieve 38 Hz. PMID:26426929

  1. EDITORIAL: Semiconductor nanotechnology: novel materials and devices for electronics, photonics and renewable energy applications Semiconductor nanotechnology: novel materials and devices for electronics, photonics and renewable energy applications

    NASA Astrophysics Data System (ADS)

    Goodnick, Stephen; Korkin, Anatoli; Krstic, Predrag; Mascher, Peter; Preston, John; Zaslavsky, Alex

    2010-04-01

    Electronic and photonic information technology and renewable energy alternatives, such as solar energy, fuel cells and batteries, have now reached an advanced stage in their development. Cost-effective improvements to current technological approaches have made great progress, but certain challenges remain. As feature sizes of the latest generations of electronic devices are approaching atomic dimensions, circuit speeds are now being limited by interconnect bottlenecks. This has prompted innovations such as the introduction of new materials into microelectronics manufacturing at an unprecedented rate and alternative technologies to silicon CMOS architectures. Despite the environmental impact of conventional fossil fuel consumption, the low cost of these energy sources has been a long-standing economic barrier to the development of alternative and more efficient renewable energy sources, fuel cells and batteries. In the face of mounting environmental concerns, interest in such alternative energy sources has grown. It is now widely accepted that nanotechnology offers potential solutions for securing future progress in information and energy technologies. The Canadian Semiconductor Technology Conference (CSTC) forum was established 25 years ago in Ottawa as an important symbol of the intrinsic strength of the Canadian semiconductor research and development community, and the Canadian semiconductor industry as a whole. In 2007, the 13th CSTC was held in Montreal, moving for the first time outside the national capital region. The first three meetings in the series of 'Nano and Giga Challenges in Electronics and Photonics'— NGCM2002 in Moscow, NGCM2004 in Krakow, and NGC2007 in Phoenix— were focused on interdisciplinary research from the fundamentals of materials science to the development of new system architectures. In 2009 NGC2009 and the 14th Canadian Semiconductor Technology Conference (CSTC2009) were held as a joint event, hosted by McMaster University (10-14 August, Hamilton, Ontario, Canada) and the scope was expanded to include renewable energy research and development. This special issue of Nanotechnology is devoted to a better understanding of the function and design of semiconductor devices that are relevant to information technology (both electronics and photonics based) and renewable energy applications. The papers contained in this special issue are selected from the NGC/CSTC2009 symposium. Among them is a report by Ray LaPierre from McMaster University and colleagues at the University of Waterloo in Canada on the ability to manipulate single spins in nanowire quantum bits. The paper also reports the development of a testbed of a few qubits for general quantum information processing tasks [1]. Lower cost and greater energy conversion efficiency compared with thin film devices have led to a high level of activity in nanowire research related to photovoltaic applications. This special issue also contains results from an impedance spectroscopy study of core-shell GaAs nanowires to throw light on the transport and recombination mechanisms relevant to solar cell research [2]. Information technology research and renewable energy sources are research areas of enormous public interest. This special issue addresses both theoretical and experimental achievements and provides a stimulating outlook for technological developments in these highly topical fields of research. References [1] Caram J, Sandoval C, Tirado M, Comedi D, Czaban J, Thompson D A and LaPierre R R 2101 Nanotechnology 21 134007 [2] Baugh J, Fung J S and LaPierre RR 2010 Nanotechnology 21 134018

  2. Feasibility study of a novel rotational and translational method for linac-based intensity modulated total marrow irradiation.

    PubMed

    Jiang, Bo; Dai, Jianrong; Zhang, Ye; Zhang, Ke

    2012-06-01

    Conventional TBI is primarily limited by the toxicity to organs at risk because of impossibility of sparing critical organs. The purpose of this study is to investigate the feasibility of a novel rotational and translational IMRT method (RTM) which able to conform the radiation dose to target organs and reduce critical organ dose for TMI using linac. To assess the feasibility, we investigated the planning and delivery of total marrow irradiation (TMI) using this method. The treatment plannig study showed that target coverage was achieved with 90% of the target volume receiving 100% of the prescription dose. Doses to critical structures indicated that a 1.28- to 2.35-fold reduction in median dose is achieved with total-marrow RTM compared with conventional TBI. Delivery of Rando phantom and TLD measurement demonstrated an accurate dose delivery (ranged from -6% to 7%) to the target and critical organs. Results from this study suggests that RTM can be accurately delivered and reduce irradiation to all critical organs with good target coverage. PMID:22376131

  3. SU-E-J-239: IMRT Planning of Prostate Cancer for a MRI-Linac Based On MRI Only

    SciTech Connect

    Chen, X; Prior, P; Paulson, E; Lawton, C; Li, X

    2014-06-01

    Purpose: : To investigate dosimetric differences between MRI- and CT-based IMRT planning for prostate cancer, the impact of a magnetic field in a MRI-Linac, and to explore the feasibility of IMRT planning based on MRI alone. Methods: IMRT plans were generated based on CT and MRI images acquired on two representative prostate-cancer patients using clinical dose volume constraints. A research planning system (Monaco, Elekta), which employs a Monte Carlo dose engine and includes a perpendicular magnetic field of 1.5T from an MRI-Linac, was used. Bulk electron density assignments based on organ-specific values from ICRU 46 were used to convert MRI (T2) to pseudo CT. With the same beam configuration as in the original CT plan, 5 additional plans were generated based on CT or MRI, with or without optimization (i.e., just recalculation) and with or without the magnetic field. The plan quality in terms of commonly used dose volume (DV) parameters for all plans was compared. The statistical uncertainty on dose was < 1%. Results: For plans with the same contour set but without re-optimization, the DV parameters were different from those for the original CT plan, mostly less than 5% with a few exceptions. These differences were reduced to mostly less than 3% when the plans were re-optimized. For plans with contours from MRI, the differences in the DV parameters varied depending on the difference in the contours as compared to CT. For the optimized plans with contours from MR, the differences for PTV were less than 3%. Conclusion: The prostate IMRT plans based on MRI-only for a MR-Linac were practically similar as compared to the CT plan under the same beam and optimization configuration if the difference on the structure delineation is excluded, indicating the feasibility of using MRI-only for prostate IMRT.

  4. Development of mini linac-based positron source and an efficient positronium convertor for positively charged antihydrogen production

    NASA Astrophysics Data System (ADS)

    Muranaka, T.; Debu, P.; Dupré, P.; Liszkay, L.; Mansoulie, B.; Pérez, P.; Rey, J. M.; Ruiz, N.; Sacquin, Y.; Crivelli, P.; Gendotti, U.; Rubbia, A.

    2010-04-01

    We have installed in Saclay a facility for an intense positron source in November 2008. It is based on a compact 5.5 MeV electron linac connected to a reaction chamber with a tungsten target inside to produce positrons via pair production. The expected production rate for fast positrons is 5·1011 per second. The study of moderation of fast positrons and the construction of a slow positron trap are underway. In parallel, we have investigated an efficient positron-positronium convertor using porous silica materials. These studies are parts of a project to produce positively charged antihydrogen ions aiming to demonstrate the feasibility of a free fall antigravity measurement of neutral antihydrogen.

  5. A new scheme to accumulate positrons in a Penning-Malmberg trap with a linac-based positron pulsed source

    SciTech Connect

    Dupre, P.

    2013-03-19

    The Gravitational Behaviour of Antimatter at Rest experiment (GBAR) is designed to perform a direct measurement of the weak equivalence principle on antimatter by measuring the acceleration of anti-hydrogen atoms in the gravitational field of the Earth. The experimental scheme requires a high density positronium (Ps) cloud as a target for antiprotons, provided by the Antiproton Decelerator (AD) - Extra Low Energy Antiproton Ring (ELENA) facility at CERN. The Ps target will be produced by a pulse of few 10{sup 10} positrons injected onto a positron-positronium converter. For this purpose, a slow positron source using an electron Linac has been constructed at Saclay. The present flux is comparable with that of {sup 22}Na-based sources using solid neon moderator. A new positron accumulation scheme with a Penning-Malmberg trap has been proposed taking advantage of the pulsed time structure of the beam. In the trap, the positrons are cooled by interaction with a dense electron plasma. The overall trapping efficiency has been estimated to be {approx}70% by numerical simulations.

  6. SU-E-J-48: Imaging Origin-Radiation Isocenter Coincidence for Linac-Based SRS with Novalis Tx

    SciTech Connect

    Geraghty, C; Workie, D; Hasson, B

    2015-06-15

    Purpose To implement and evaluate an image-based Winston-Lutz (WL) test to measure the displacement between ExacTrac imaging origin and radiation isocenter on a Novalis Tx system using RIT V6.2 software analysis tools. Displacement between imaging and radiation isocenters was tracked over time. The method was applied for cone-based and MLC-based WL tests. Methods The Brainlab Winston-Lutz phantom was aligned to room lasers. The ExacTrac imaging system was then used to detect the Winston- Lutz phantom and obtain the displacement between the center of the phantom and the imaging origin. EPID images of the phantom were obtained at various gantry and couch angles and analyzed with RIT calculating the phantom center to radiation isocenter displacement. The RIT and Exactrac displacements were combined to calculate the displacement between imaging origin and radiation isocenter. Results were tracked over time. Results Mean displacements between ExacTrac origin and radiation isocenter were: VRT: −0.1mm ± 0.3mm, LNG: 0.5mm ± 0.2mm, LAT: 0.2mm ± 0.2mm (vector magnitude of 0.7 ± 0.2mm). Radiation isocenter was characterized by the mean of the standard deviations of the WL phantom displacements: σVRT: 0.2mm, σLNG: 0.4mm, σLAT: 0.6mm. The linac couch base was serviced to reduce couch walkout. This reduced σLAT to 0.2mm. These measurements established a new baseline of radiation isocenter-imaging origin coincidence. Conclusion The image-based WL test has ensured submillimeter localization accuracy using the ExacTrac imaging system. Standard deviations of ExacTrac-radiation isocenter displacements indicate that average agreement within 0.3mm is possible in each axis. This WL test is a departure from the tradiational WL in that imaging origin/radiation isocenter agreement is the end goal not lasers/radiation isocenter.

  7. SYNCHROTRON RADIATION, FREE ELECTRON LASER, APPLICATION OF NUCLEAR TECHNOLOGY, ETC.: Study on the characteristics of linac based THz light source

    NASA Astrophysics Data System (ADS)

    Zhu, Xiong-Wei; Wang, Shu-Hong; Chen, Sen-Yu

    2009-10-01

    There are many methods based on linac for THz radiation production. As one of the options for the Beijing Advanced Light, an ERL test facility is proposed for THz radiation. In this test facility, there are 4 kinds of methods to produce THz radiation: coherent synchrotron radiation (CSR), synchrotron radiation (SR), low gain FEL oscillator, and high gain SASE FEL. In this paper, we study the characteristics of the 4 kinds of THz light sources.

  8. Development of a Comprehensive Linac-based Quality Assurance Program for a Retrofitted Micro-MLC SRS System

    NASA Astrophysics Data System (ADS)

    Hancock, George

    In Stereotactic Radiosurgery, one of the most import factors that must be measured is the accuracy of the localization system, whether it be lasers or camera system; and the coincidence of the localized isocenter to the radiation isocenter. According to TG-142 the minimum deviation between the isocenter determined by the localization device and the radiation isocenter of the machine must be no more that 1 mm. In addition, the minimum deviation, also recommended by TG-142, between the radiation isocenter and the mechanical isocenter of the machine must be no more that 1mm. The purpose of this research was to develop a method that both of these parameters could be measured and add these tests to our patient specific QA, monthly QA, and annual QA procedures. A plastic phantom was constructed with holes drilled in each of the sides to meet at a common point in the middle of the phantom. This common intersection was then set as the isocenter for the treatment beams, and the coordinates of the point were sent to the camera system. Measurements were than taken with both the EPID and GafChromic film with the use of rigid tungsten rods in each hole to mark the position of the holes on the film and EPID. The films were then scanned and the field edges and isocenter positions were determined by taking the coordinates of a point that was halfway between the minimum and maximum points in all cases.

  9. Ultrafast harmonic rf kicker design and beam dynamics analysis for an energy recovery linac based electron circulator cooler ring

    DOE PAGESBeta

    Huang, Yulu; Wang, Haipeng; Rimmer, Robert A.; Wang, Shaoheng; Guo, Jiquan

    2016-08-01

    An ultrafast kicker system is being developed for the energy recovery linac (ERL) based electron circulator cooler ring (CCR) in the proposed Jefferson Lab Electron Ion Collider (JLEIC, previously named MEIC). In the CCR, the injected electron bunches can be recirculated while performing ion cooling for 10–30 turns before the extraction, thus reducing the recirculation beam current in the ERL to 1/10–1/30 (150mA–50 mA) of the cooling beam current (up to 1.5 A). Assuming a bunch repetition rate of 476.3 MHz and a recirculating factor of 10 in the CCR, the kicker is required to operate at a pulse repetitionmore » rate of 47.63 MHz with pulse width of around 2 ns, so that only every 10th bunch in the CCR will experience a transverse kick while the rest of the bunches will not be disturbed. Such a kicker pulse can be synthesized by ten harmonic modes of the 47.63 MHz kicker pulse repetition frequency, using up to four quarter wavelength resonator (QWR) based deflecting cavities. In this paper, several methods to synthesize such a kicker waveform will be discussed and a comparison of their beam dynamics performance is made using ELEGANT. Four QWR cavities are envisaged with high transverse shunt impedance requiring less than 100 W of total rf power for a Flat-Top kick pulse. Multipole fields due to the asymmetry of this type of cavity are analyzed. The transverse emittance growth due to the sextupole component is simulated in ELEGANT. In conclusion, off-axis injection and extraction issues and beam optics using a multicavity kick-drift scheme will also be discussed.« less

  10. Comptonization of X-rays by low-temperature electrons. [photon wavelength redistribution in cosmic sources

    NASA Technical Reports Server (NTRS)

    Illarionov, A.; Kallman, T.; Mccray, R.; Ross, R.

    1979-01-01

    A method is described for calculating the spectrum that results from the Compton scattering of a monochromatic source of X-rays by low-temperature electrons, both for initial-value relaxation problems and for steady-state spatial diffusion problems. The method gives an exact solution of the inital-value problem for evolution of the spectrum in an infinite homogeneous medium if Klein-Nishina corrections to the Thomson cross section are neglected. This, together with approximate solutions for problems in which Klein-Nishina corrections are significant and/or spatial diffusion occurs, shows spectral structure near the original photon wavelength that may be used to infer physical conditions in cosmic X-ray sources. Explicit results, shown for examples of time relaxation in an infinite medium and spatial diffusion through a uniform sphere, are compared with results obtained by Monte Carlo calculations and by solving the appropriate Fokker-Planck equation.

  11. First results from electron-photon damage equivalence studies on a generic ethylene-propylene rubber

    SciTech Connect

    Buckalew, W.H.

    1986-04-01

    As part of a simulator adequacy assessment program, the relative effectiveness of electrons and photons to produce damage in a generic ethylene propylene rubber (EPR) has been investigated. The investigation was limited in extent in that a single EPR material, in three thickness, was exposed to Cobalt-60 photons and three electron beam energies. Basing material damage on changes in the EPR mechanical properties elongation and tensile strength, we observed that EPR damage was a smoothly varying function of absorbed energy and independent of irradiating particle type. EPR damage tracked equally well as a function of both incident particle energy and material front surface dose. Based on these preliminary data, we tentatively concluded that a correlation between particle, particle energy, and material damage (as measured by changes in material elongation and/or tensile strength) has been demonstrated. 14 figs.

  12. Integral functions of electron lateral distribution and their fluctuations in electron-photon cascades

    NASA Technical Reports Server (NTRS)

    Ivanenko, I. P.; Kanevsky, B. L.; Kirillov, A. A.; Linde, I. A.; Lyutov, Y. G.

    1985-01-01

    Monte Carlo simulated lateral distribution functions for electrons of EPC developing in lead, at superhigh energies (.1-1 PeV) for depths t or = 60 c.u. delta t=1t. c.u. are presented. The higher moment characteristics, i.e., variation, asymmetry, excess, are presented along with analytical solutions for the same characteristics at fixed observation level calculated to theory approximations A and B by using numerical inversion of the Laplace transformation. The conclusion is made of a complex, usually non-Gaussian shape of the function of the particle number distribution within a circle of given radius at fixed depth.

  13. Instrumentation and beam dynamics study of advanced electron-photon facility in Indiana University

    NASA Astrophysics Data System (ADS)

    Luo, Tianhuan

    The Advanced eLectron-PHoton fAcility (ALPHA) is a compact electron accelerator under construction and being commissioned at the Indiana University Center for Exploration of Energy and Matter (CEEM). In this thesis, we have studied the refurbished Cooler Injector Synchrotron (CIS) RF cavity using both the transmission line model and SUPERFISH simulation. Both low power and high power RF measurements have been carried out to characterize the cavity. Considering the performance limit of ferrite, we have designed a new ferrite loaded, co-axial quarter wave like cavity with similar structure but a more suitable ferrite material. We have also designed a traveling wave stripline kicker for fast extraction by POISSON and Microwave Studio. The strips' geometry is trimmed to maximize the uniformity of the kicking field and match the impedance of the power cables. The time response simulation shows the kicker is fast enough for machine operation. The pulsed power supply requirement has also been speci ed. For the beam diagnosis in the longitudinal direction, we use a wideband Wall Gap Monitor (WGM) served in CIS. With proper shielding and amplification to get good WGM signal, we have characterized the injected and extracted beam signal in single pass commissioning, and also verified the debunching effect of the ALPHA storage ring. A modulation-demodulation signal processing method is developed to measure the current and longitudinal profile of injected beam. By scanning the dipole strength in the injection line, we have reconstructed the tomography of the longitudinal phase space of the LINAC beam. In the accumulation mode, ALPHA will be operated under a low energy and high current condition, where intra beam scattering (IBS) becomes a dominant effect on the beam emittance. A self consistent simulation, including IBS effect, gas scattering and linear coupling, has been carried out to calculate the emittance of the stored beam.

  14. Electron-photon transport using the EGS4 (Electron Gamma Shower) Monte Carlo Code

    SciTech Connect

    Nelson, W.R.; Hirayama, H.; Rogers, D.W.O.

    1986-01-01

    The EGS (Electron Gamma Shower) code system was formally introduced in 1978 as a package, most commonly referred to as ESG3. It was designed to simulate electromagnetic cascades in various geometries and at energies up to a few thousand gigaelectron volts and down to cutoff kinetic energies of 0.1 MeV (photons) and 1 MeV (electrons). There have been many requests to extend EGS3 down to lower energies and this is a major, but not the only, reason for creating EGS4, which is now available for general distribution and is the subject of this presentation. A summary is given of the main features of the ESG4 code system, including statements about the physics that has been put into it and what can be realistically simulated. 6 refs.

  15. Electron, photon, and ion beams from the relativistic interaction of Petawatt laser pulses with solid targets

    SciTech Connect

    Hatchett, Stephen P.; Brown, Curtis G.; Cowan, Thomas E.; Henry, Eugene A.; Johnson, Joy S.; Key, Michael H.; Koch, Jeffrey A.; Langdon, A. Bruce; Lasinski, Barbara F.; Lee, Richard W.

    2000-05-01

    In recent Petawatt laser experiments at Lawrence Livermore National Laboratory, several hundred joules of 1 {mu}m laser light in 0.5-5.0-ps pulses with intensities up to 3x10{sup 20} W cm{sup -2} were incident on solid targets and produced a strongly relativistic interaction. The energy content, spectra, and angular patterns of the photon, electron, and ion radiations have all been diagnosed in a number of ways, including several novel (to laser physics) nuclear activation techniques. About 40%-50% of the laser energy is converted to broadly beamed hot electrons. Their beam centroid direction varies from shot to shot, but the resulting bremsstrahlung beam has a consistent width. Extraordinarily luminous ion beams (primarily protons) almost precisely normal to the rear of various targets are seen--up to 3x10{sup 13} protons with kT{sub ion}{approx}several MeV representing {approx}6% of the laser energy. Ion energies up to at least 55 MeV are observed. The ions appear to originate from the rear target surfaces. The edge of the ion beam is very sharp, and collimation increases with ion energy. At the highest energies, a narrow feature appears in the ion spectra, and the apparent size of the emitting spot is smaller than the full back surface area. Any ion emission from the front of the targets is much less than from the rear and is not sharply beamed. The hot electrons generate a Debye sheath with electrostatic fields of order MV per micron, which apparently accelerate the ions. (c) 2000 American Institute of Physics.

  16. Parallel Finite Element Electron-Photon Transport Analysis on 2-D Unstructured Mesh

    SciTech Connect

    Drumm, C.R.

    1999-01-01

    A computer code has been developed to solve the linear Boltzmann transport equation on an unstructured mesh of triangles, from a Pro/E model. An arbitriwy arrangement of distinct material regions is allowed. Energy dependence is handled by solving over an arbitrary number of discrete energy groups. Angular de- pendence is treated by Legendre-polynomial expansion of the particle cross sections and a discrete ordinates treatment of the particle fluence. The resulting linear system is solved in parallel with a preconditioned conjugate-gradients method. The solution method is unique, in that the space-angle dependence is solved si- multaneously, eliminating the need for the usual inner iterations. Electron cross sections are obtained from a Goudsrnit-Saunderson modifed version of the CEPXS code. A one-dimensional version of the code has also been develop@ for testing and development purposes.

  17. Electron-photon interaction in a quantum point contact coupled to a microwave resonator

    NASA Astrophysics Data System (ADS)

    Mendes, Udson C.; Mora, Christophe

    2016-06-01

    We study a single-mode cavity weakly coupled to a voltage-biased quantum point contact. In a perturbative analysis, the lowest order predicts a thermal state for the cavity photons, driven by the emission noise of the conductor. The cavity is thus emptied as all transmission probabilities of the quantum point contact approach one or zero. Two-photon processes are identified at higher coupling, and pair absorption dominates over pair emission for all bias voltages. As a result, the number of cavity photons, the cavity damping rate, and the second-order coherence g(2 ) are all reduced and exhibit less bunching than the thermal state. These results are obtained with a Keldysh path-integral formulation and reproduced with rate equations. They can be seen as a backaction of the cavity measuring the electronic noise. Extending the standard P (E ) theory to a steady-state situation, we compute the modified noise properties of the conductor and find quantitative agreement with the perturbative calculation.

  18. Electrons, Photons, and Force: Quantitative Single-Molecule Measurements from Physics to Biology

    PubMed Central

    2011-01-01

    Single-molecule measurement techniques have illuminated unprecedented details of chemical behavior, including observations of the motion of a single molecule on a surface, and even the vibration of a single bond within a molecule. Such measurements are critical to our understanding of entities ranging from single atoms to the most complex protein assemblies. We provide an overview of the strikingly diverse classes of measurements that can be used to quantify single-molecule properties, including those of single macromolecules and single molecular assemblies, and discuss the quantitative insights they provide. Examples are drawn from across the single-molecule literature, ranging from ultrahigh vacuum scanning tunneling microscopy studies of adsorbate diffusion on surfaces to fluorescence studies of protein conformational changes in solution. PMID:21338175

  19. ITS Version 4.0: Electron/photon Monte Carlo transport codes

    SciTech Connect

    Halbleib, J.A,; Kensek, R.P.; Seltzer, S.M.

    1995-07-01

    The current publicly released version of the Integrated TIGER Series (ITS), Version 3.0, has been widely distributed both domestically and internationally, and feedback has been very positive. This feedback as well as our own experience have convinced us to upgrade the system in order to honor specific user requests for new features and to implement other new features that will improve the physical accuracy of the system and permit additional variance reduction. This presentation we will focus on components of the upgrade that (1) improve the physical model, (2) provide new and extended capabilities to the three-dimensional combinatorial-geometry (CG) of the ACCEPT codes, and (3) permit significant variance reduction in an important class of radiation effects applications.

  20. Chaotic compound states in atomic processes: electron, photon and atom scattering, recombination, photoionization and radiation

    NASA Astrophysics Data System (ADS)

    Flambaum, Victor; Berengut, Julian; Dzuba, Vladimir; Gribakin, Gleb; Harabati, Celal; Kozlov, Michael

    2016-05-01

    Level density of many-body states exponentially increases with the number of excited particles. When residual interaction exceeds the interval between these levels, the eigenstates (compound states) become chaotic superpositions of of thousands, or even millions of Slater determinant basis states.This situation takes place in highly excited nuclei, rare-earth and actinide atoms, open f-shell ions excited by the electron recombination and in ultracold collisions of open f-shell atoms. We derived formulas for the resonant multi-electron recombination via di-electron doorway states leading to the many-electron compound resonances and performed numerical calculations for the electron recombination with gold (Au+25) and tungsten ions (W+1724). A recent experiment showed that the electron recombination of tungsten ion W20+exceeds the direct recombination by three order of magnitude. Our calculations agree with the experimental results for Au+25 and W20+. Other manifestation of chaos are enhancement of weak interactions and Raman photon scattering, and suppression of the photoionization.

  1. An empirical method for deriving RBE values associated with electrons, photons and radionuclides.

    PubMed

    Bellamy, M; Puskin, J; Hertel, N; Eckerman, K

    2015-12-01

    There is substantial evidence to justify using relative biological effectiveness (RBE) values of >1 for low-energy electrons and photons. But, in the field of radiation protection, radiation associated with low linear energy transfer has been assigned a radiation weighting factor wR of 1. This value may be suitable for radiation protection but, for risk considerations, it is important to evaluate the potential elevated biological effectiveness of radiation to improve the quality of risk estimates. RBE values between 2 and 3 for tritium are implied by several experimental measurements. Additionally, elevated RBE values have been found for other similar low-energy radiation sources. In this work, RBE values are derived for electrons based upon the fractional deposition of absorbed dose of energies less than a few kiloelectron volts. Using this empirical method, RBE values were also derived for monoenergetic photons and 1070 radionuclides from ICRP Publication 107 for which photons and electrons are the primary emissions. PMID:25636403

  2. Semiconductor Nanotechnology: Novel Materials and Devices for Electronics, Photonics, and Renewable Energy Applications

    SciTech Connect

    Goodnick, Stephen; Korkin, Anatoli; Krstic, Predrag S; Mascher, Peter; Preston, John; Zaslavsky, Alex

    2010-03-01

    Electronic and photonic information technology and renewable energy alternatives, such as solar energy, fuel cells and batteries, have now reached an advanced stage in their development. Cost-effective improvements to current technological approaches have made great progress, but certain challenges remain. As feature sizes of the latest generations of electronic devices are approaching atomic dimensions, circuit speeds are now being limited by interconnect bottlenecks. This has prompted innovations such as the introduction of new materials into microelectronics manufacturing at an unprecedented rate and alternative technologies to silicon CMOS architectures. Despite the environmental impact of conventional fossil fuel consumption, the low cost of these energy sources has been a long-standing economic barrier to the development of alternative and more efficient renewable energy sources, fuel cells and batteries. In the face of mounting environmental concerns, interest in such alternative energy sources has grown. It is now widely accepted that nanotechnology offers potential solutions for securing future progress in information and energy technologies. The Canadian Semiconductor Technology Conference (CSTC) forum was established 25 years ago in Ottawa as an important symbol of the intrinsic strength of the Canadian semiconductor research and development community, and the Canadian semiconductor industry as a whole. In 2007, the 13th CSTC was held in Montreal, moving for the first time outside the national capital region. The first three meetings in the series of Nano and Giga Challenges in Electronics and Photonics NGCM2002 in Moscow, NGCM2004 in Krakow, and NGC2007 in Phoenix were focused on interdisciplinary research from the fundamentals of materials science to the development of new system architectures. In 2009 NGC2009 and the 14th Canadian Semiconductor Technology Conference (CSTC2009) were held as a joint event, hosted by McMaster University (10 14 August, Hamilton, Ontario, Canada) and the scope was expanded to include renewable energy research and development. This special issue of Nanotechnology is devoted to a better understanding of the function and design of semiconductor devices that are relevant to information technology (both electronics and photonics based) and renewable energy applications. The papers contained in this special issue are selected from the NGC/CSTC2009 symposium. Among them is a report by Ray LaPierre from McMaster University and colleagues at the University of Waterloo in Canada on the ability to manipulate single spins in nanowire quantum bits. The paper also reports the development of a testbed of a few qubits for general quantum information processing tasks [1]. Lower cost and greater energy conversion efficiency compared with thin film devices have led to a high level of activity in nanowire research related to photovoltaic applications. This special issue also contains results from an impedance spectroscopy study of core shell GaAs nanowires to throw light on the transport and recombination mechanisms relevant to solar cell research [2]. Information technology research and renewable energy sources are research areas of enormous public interest. This special issue addresses both theoretical and experimental achievements and provides a stimulating outlook for technological developments in these highly topical fields of research. References [1] Caram J, Sandoval C, Tirado M, Comedi D, Czaban J, Thompson D A and LaPierre R R 2010 Electrical characteristics of core shell p-n GaAs nanowire structures with Te as the n-dopant Nanotechnology 21 134007 [2] Baugh J, Fung J S and LaPierre R R 2010 Building a spin quantum bit register using semiconductor nanowires Nanotechnology 21 134018

  3. Electron, Photon, and Ion Beams from the Relativistic Interaction of Petawatt Laser Pulses with Solid Targets

    SciTech Connect

    Hatchett, S.P.; Brown, C.G.; Cowan, T.E.; Henry, E.A.; Johnson, J.; Key, M.H.; Koch, J.A.; Langdon, A.B.; Lasinski, B.F.; Lee, R.W.; Mackinnon, A.J.; Pennington, D.M.; Perry, M.D.; Phillips, T.W.; Roth, M.; Sangster, T.C.; Singh, M.S.; Snavely, R.A.; Stoyer, M.A.; Wilks, S.C.; Yasuike, K.

    1999-11-12

    In our Petawatt laser experiments several hundred joules of 1 {micro}m laser light in 0.5-5.0 ps pulses with intensities up to 3 x 10{sup 20}Wcm{sup -2} were incident on solid targets producing a strongly relativistic interaction. The energy content, spectra, and angular patterns of the photon, electron, and ion radiations were diagnosed in a number of ways, including several novel (to laser physics) nuclear activation techniques. From the beamed bremsstrahlung we infer that about 40-50% of the laser energy is converted to broadly beamed hot electrons. Their direction centroid varies from shot to shot, but the beam has a consistent width. Extraordinarily luminous ion beams almost precisely normal to the rear of various targets are seen--up to 3 x 10{sup 13} protons with kT{sub ion} {approx} several MeV representing {approx}6% of the laser energy. We observe ion energies up to at least 55 MeV. The ions appear to originate from the rear target surfaces. The edge of the ion beam is very sharp, and collimation increases with ion energy. At the highest energies, a narrow feature appears in the ion spectra, and the apparent size of the emitting spot is smaller than the full back surface area. Any ion emission from the front of the targets is much less than from the rear and is not sharply beamed. The hot electrons generate a Debye sheath with electrostatic fields of order MV per micron which apparently accelerate the ions.

  4. Instrumentation and Beam Dynamics Study of Advanced Electron-Photon Facility in Indiana University

    SciTech Connect

    Luo, Tianhuan

    2011-08-01

    The Advanced eLectron-PHoton fAcility (ALPHA) is a compact electron accelerator under construction and being commissioned at the Indiana University Center for Exploration of Energy and Matter (CEEM). In this thesis, we have studied the refurbished Cooler Injector Synchrotron (CIS) RF cavity using both the transmission line model and SUPERFISH simulation. Both low power and high power RF measurements have been carried out to characterize the cavity. Considering the performance limit of ferrite, we have designed a new ferrite loaded, co-axial quarter wave like cavity with similar structure but a more suitable ferrite material. We have also designed a traveling wave stripline kicker for fast extraction by POISSON and Microwave Studio. The strips geometry is trimmed to maximize the uniformity of the kicking field and match the impedance of the power cables. The time response simulation shows the kicker is fast enough for machine operation. The pulsed power supply requirement has also been specified. For the beam diagnosis in the longitudinal direction, we use a wideband Wall Gap Monitor (WGM) served in CIS. With proper shielding and amplification to get good WGM signal, we have characterized the injected and extracted beam signal in single pass commissioning, and also verified the debunching effect of the ALPHA storage ring. A modulation-demodulation signal processing method is developed to measure the current and longitudinal profile of injected beam. By scanning the dipole strength in the injection line, we have reconstructed the tomography of the longitudinal phase space of the LINAC beam. In the accumulation mode, ALPHA will be operated under a low energy and high current condition, where intra beam scattering (IBS) becomes a dominant effect on the beam emittance. A self consistent simulation, including IBS effect, gas scattering and linear coupling, has been carried out to calculate the emittance of the stored beam.

  5. Discrete Chromatic Aberrations Arising from Photoinduced Electron-Photon Interactions in Ultrafast Electron Microscopy.

    PubMed

    Plemmons, Dayne A; Flannigan, David J

    2016-05-26

    In femtosecond ultrafast electron microscopy (UEM) experiments, the initial excitation period is composed of spatiotemporal overlap of the temporally commensurate pump photon pulse and probe photoelectron packet. Generation of evanescent near-fields at the nanostructure specimens produces a dispersion relation that enables coupling of the photons (ℏω = 2.4 eV, for example) and freely propagating electrons (200 keV, for example) in the near-field. Typically, this manifests as discrete peaks occurring at integer multiples (n) of the photon energy in the low-loss/gain region of electron-energy spectra (i.e., at 200 keV ± nℏω eV). Here, we examine the UEM imaging resolution implications of the strong inelastic near-field interactions between the photons employed in optical excitation and the probe photoelectrons. We find that the additional photoinduced energy dispersion occurring when swift electrons pass through intense evanescent near-fields results in a discrete chromatic aberration that limits the spatial resolving power to several angstroms during the excitation period. PMID:27111530

  6. Electron-photon coupling in semimetals in a high magnetic field

    SciTech Connect

    Mihaila, Bogdan; Albers, Robert C; Littlewood, Peter B

    2009-01-01

    We consider the effect of electron-phonon coupling in semimetals in high magnetic fields, with regard to elastic modes that can lead to a redistribution of carriers between pockets. We show that in a clean three dimensional system, at each Landau level crossing, this leads to a discontinuity in the magnetostriction, and a divergent contribution to the elastic modulus. We estimate the magnitude of this effect in the group V semimetal Bismuth.

  7. Universal I/O board for the laser-electron photons experiments at SPring-8

    NASA Astrophysics Data System (ADS)

    Sugaya, Y.; Nomachi, M.

    1999-11-01

    A data acquisition system on the basis of network technologies has been developed for experiments using high-energy photons from backward-Compton scattering between laser lights and 8 GeV electrons at SPring-8. A universal I/O VME-board (UIO) is designed as a buffer-sequencer module with a reconfigurable logic circuit and a 1 Mbyte memory. The UIO is applied as a high-speed module for flexible data readout and buffering. Data from the various detectors are transferred from the UIO to a VME CPU-board in the common format. Altera Hardware Description Language is used to read data from a fast encoding and readout ADC (FERA) system for TOF counters and Cherenkov counters.

  8. An Empirical Method for deriving RBE values associated with Electrons, Photons and Radionuclides

    DOE PAGESBeta

    Bellamy, Michael B; Puskin, J.; Eckerman, Keith F.; Hertel, Nolan

    2015-01-01

    There is substantial evidence to justify using relative biological effectiveness (RBE) values greater than one for low-energy electrons and photons. But, in the field of radiation protection, radiation associated with low linear energy transfer (LET) has been assigned a radiation weighting factor wR of one. This value may be suitable for radiation protection but, for risk considerations, it is important to evaluate the potential elevated biological effectiveness of radiation to improve the quality of risk estimates. RBE values between 2 and 3 for tritium are implied by several experimental measurements. Additionally, elevated RBE values have been found for other similarmore » low-energy radiation sources. In this work, RBE values are derived for electrons based upon the fractional deposition of absorbed dose of energies less than a few keV. Using this empirical method, RBE values were also derived for monoenergetic photons and 1070 radionuclides from ICRP Publication 107 for which photons and electrons are the primary emissions.« less

  9. An Empirical Method for deriving RBE values associated with Electrons, Photons and Radionuclides

    SciTech Connect

    Bellamy, Michael B; Puskin, J.; Eckerman, Keith F.; Hertel, Nolan

    2015-01-01

    There is substantial evidence to justify using relative biological effectiveness (RBE) values greater than one for low-energy electrons and photons. But, in the field of radiation protection, radiation associated with low linear energy transfer (LET) has been assigned a radiation weighting factor wR of one. This value may be suitable for radiation protection but, for risk considerations, it is important to evaluate the potential elevated biological effectiveness of radiation to improve the quality of risk estimates. RBE values between 2 and 3 for tritium are implied by several experimental measurements. Additionally, elevated RBE values have been found for other similar low-energy radiation sources. In this work, RBE values are derived for electrons based upon the fractional deposition of absorbed dose of energies less than a few keV. Using this empirical method, RBE values were also derived for monoenergetic photons and 1070 radionuclides from ICRP Publication 107 for which photons and electrons are the primary emissions.

  10. NOTE: Determination of isocentric machine parameters for inclined treatment volumes: a single solution for angled transverse or coronal treatment planes

    NASA Astrophysics Data System (ADS)

    Bradley, F. L.

    2001-01-01

    The derivation of the trigonometric equations necessary to calculate gantry, floor and collimator settings for a treatment plane at an angle φ to the transverse plane of the patient has been described previously. The derivation of a second set of equations to facilitate treatment in a plane at an angle φ to the coronal plane has also been described previously. This work reinterprets the geometry of inclined volumes and shows that essentially only one set of equations is required to determine the settings for treatment planes at an angle φ to either the transverse or coronal planes of the patient.

  11. Detection of dark states in two-dimensional electronic photon-echo signals via ground-state coherence

    SciTech Connect

    Egorova, Dassia

    2015-06-07

    Several recent experiments report on possibility of dark-state detection by means of so called beating maps of two-dimensional photon-echo spectroscopy [Ostroumov et al., Science 340, 52 (2013); Bakulin et al., Ultrafast Phenomena XIX (Springer International Publishing, 2015)]. The main idea of this detection scheme is to use coherence induced upon the laser excitation as a very sensitive probe. In this study, we investigate the performance of ground-state coherence in the detection of dark electronic states. For this purpose, we simulate beating maps of several models where the excited-state coherence can be hardly detected and is assumed not to contribute to the beating maps. The models represent strongly coupled electron-nuclear dynamics involving avoided crossings and conical intersections. In all the models, the initially populated optically accessible excited state decays to a lower-lying dark state within few hundreds femtoseconds. We address the role of Raman modes and of interstate-coupling nature. Our findings suggest that the presence of low-frequency Raman active modes significantly increases the chances for detection of dark states populated via avoided crossings, whereas conical intersections represent a more challenging task.

  12. Linac-based extracranial radiosurgery with Elekta volumetric modulated arc therapy and an anatomy-based treatment planning system: Feasibility and initial experience.

    PubMed

    Cilla, Savino; Deodato, Francesco; Macchia, Gabriella; Digesù, Cinzia; Ianiro, Anna; Viola, Pietro; Craus, Maurizio; Valentini, Vincenzo; Piermattei, Angelo; Morganti, Alessio G

    2016-01-01

    We reported our initial experience in using Elekta volumetric modulated arc therapy (VMAT) and an anatomy-based treatment planning system (TPS) for single high-dose radiosurgery (SRS-VMAT) of liver metastases. This study included a cohort of 12 patients treated with a 26-Gy single fraction. Single-arc VMAT plans were generated with Ergo++ TPS. The prescription isodose surface (IDS) was selected to fulfill the 2 following criteria: 95% of planning target volume (PTV) reached 100% of the prescription dose and 99% of PTV reached a minimum of 90% of prescription dose. A 1-mm multileaf collimator (MLC) block margin was added around the PTV. For a comparison of dose distributions with literature data, several conformity indexes (conformity index [CI], conformation number [CN], and gradient index [GI]) were calculated. Treatment efficiency and pretreatment dosimetric verification were assessed. Early clinical data were also reported. Our results reported that target and organ-at-risk objectives were met for all patients. Mean and maximum doses to PTVs were on average 112.9% and 121.5% of prescribed dose, respectively. A very high degree of dose conformity was obtained, with CI, CN, and GI average values equal to 1.29, 0.80, and 3.63, respectively. The beam-on-time was on average 9.3 minutes, i.e., 0.36min/Gy. The mean number of monitor units was 3162, i.e., 121.6MU/Gy. Pretreatment verification (3%-3mm) showed an optimal agreement with calculated values; mean γ value was 0.27 and 98.2% of measured points resulted with γ < 1. With a median follow-up of 16 months complete response was observed in 12/14 (86%) lesions; partial response was observed in 2/14 (14%) lesions. No radiation-induced liver disease (RILD) was observed in any patients as well no duodenal ulceration or esophagitis or gastric hemorrhage. In conclusion, this analysis demonstrated the feasibility and the appropriateness of high-dose single-fraction SRS-VMAT in liver metastases performed with Elekta VMAT and Ergo++ TPS. Preliminary clinical outcomes showed a high rate of local control and minimum incidence of acute toxicity. PMID:26994825

  13. Linac-based on-board imaging feasibility and the dosimetric consequences of head roll in head-and-neck IMRT plans

    SciTech Connect

    Kim, Gwe-Ya; Pawlicki, Todd Le, Quynh-Thu; Luxton, Gary

    2008-04-01

    Kilovoltage imaging systems on linear accelerators are used for patient localization in many clinics. The purpose of this work is to assess on-board imaging (OBI) detection of systematic setup errors and in particular, the dosimetric consequences of undetected head roll in head-and-neck intensity modulated radiation therapy (IMRT) plans when using these systems. The system used in this study was the Trilogy linear accelerator and associated software (Varian Medical Systems, Palo Alto, CA). Accuracy of OBI localization was evaluated using an anthropomorphic head phantom. The head phantom is rigidly attached to a specially designed positioning device with 5 deg. of freedom, 3 translational and 2 rotational in the axial and coronal planes. Simulated setup errors were 3 deg. and 5 deg. rotations in the axial plane and displacements of 5 mm in the left-right, anterior-posterior, and superior-inferior directions. The coordinates set by the positioning device were compared with the coordinates obtained as measured by using the image matching tools of paired 2-dimensional (2D) orthogonal image matching, and 3D cone-beam computed tomography (CT) volume matching. In addition, 6 physician-approved IMRT plans of nasopharynx and tonsil carcinoma were recalculated to evaluate the impact of undetected 3 deg. and 5 deg. head roll. Application of cone-beam CT (CBCT) for patient localization was superior to 2D matching techniques for detecting rotational setup errors. The use of CBCT allowed the determination of translational errors to within 0.5 mm, whereas kV planar was within 1 to 2 mm. Head roll in the axial plane was not easily detected with orthogonal image sets. Compared to the IMRT plans with no head roll, dose-volume histogram analysis demonstrated an average increase in the maximal spinal cord dose of 3.1% and 6.4% for 3 deg. and 5 deg. angles of rotation, respectively. Dose to the contralateral parotid was unchanged with 3 deg. roll and increased by 2.7% with 5 deg. roll. The results of this study show that volumetric setup verification using CBCT can improve bony anatomy setup detection to millimeter accuracy, and is a reliable method to detect head roll. However, the magnitude of possible dose errors due to undetected head roll suggests that CBCT does not need to be performed on a daily basis but rather weekly or bi-weekly to ensure fidelity of the head position with the immobilization system.

  14. Differences in Clinical Results After LINAC-Based Single-Dose Radiosurgery Versus Fractionated Stereotactic Radiotherapy for Patients With Vestibular Schwannomas

    SciTech Connect

    Combs, Stephanie E.; Welzel, Thomas; Schulz-Ertner, Daniela; Huber, Peter E.; Debus, Juergen

    2010-01-15

    Purpose: To evaluate the outcomes of patients with vestibular schwannoma (VS) treated with fractionated stereotactic radiotherapy (FSRT) vs. those treated with stereotactic radiosurgery (SRS). Methods and Materials: This study is based on an analysis of 200 patients with 202 VSs treated with FSRT (n = 172) or SRS (n = 30). Patients with tumor progression and/or progression of clinical symptoms were selected for treatment. In 165 out of 202 VSs (82%), RT was performed as the primary treatment for VS, and for 37 VSs (18%), RT was conducted for tumor progression after neurosurgical intervention. For patients receiving FSRT, a median total dose of 57.6 Gy was prescribed, with a median fractionation of 5 x 1.8 Gy per week. For patients who underwent SRS, a median single dose of 13 Gy was prescribed to the 80% isodose. Results: FSRT and SRS were well tolerated. Median follow-up time was 75 months. Local control was not statistically different for both groups. The probability of maintaining the pretreatment hearing level after SRS with doses of <=13 Gy was comparable to that of FSRT. The radiation dose for the SRS group (<=13 Gy vs. >13 Gy) significantly influenced hearing preservation rates (p = 0.03). In the group of patients treated with SRS doses of <=13 Gy, cranial nerve toxicity was comparable to that of the FSRT group. Conclusions: FSRT and SRS are both safe and effective alternatives for the treatment of VS. Local control rates are comparable in both groups. SRS with doses of <=13 Gy is a safe alternative to FSRT. While FSRT can be applied safely for the treatment of VSs of all sizes, SRS should be reserved for smaller lesions.

  15. Monte Carlo simulation estimates of neutron doses to critical organs of a patient undergoing 18 MV x-ray LINAC-based radiotherapy

    SciTech Connect

    Barquero, R.; Edwards, T.M.; Iniguez, M. P.; Vega-Carrillo, H.R.

    2005-12-15

    Absorbed photoneutron dose to patients undergoing 18 MV x-ray therapy was studied using Monte Carlo simulations based on the MCNPX code. Two separate transport simulations were conducted, one for the photoneutron contribution and another for neutron capture gamma rays. The phantom model used was of a female patient receiving a four-field pelvic box treatment. Photoneutron doses were determinate to be higher for organs and tissues located inside the treatment field, especially those closest to the patient's skin. The maximum organ equivalent dose per x-ray treatment dose achieved within each treatment port was 719 {mu}Sv/Gy to the rectum (180 deg. field), 190 {mu}Sv/Gy to the intestine wall (0 deg. field), 51 {mu}Sv/Gy to the colon wall (90 deg. field), and 45 {mu}Sv/Gy to the skin (270 deg. field). The maximum neutron equivalent dose per x-ray treatment dose received by organs outside the treatment field was 65 {mu}Sv/Gy to the skin in the antero-posterior field. A mean value of 5{+-}2 {mu}Sv/Gy was obtained for organs distant from the treatment field. Distant organ neutron equivalent doses are all of the same order of magnitude and constitute a good estimate of deep organ neutron equivalent doses. Using the risk assessment method of the ICRP-60 report, the greatest likelihood of fatal secondary cancer for a 70 Gy dose is estimated to be 0.02% for the pelvic postero-anterior field, the rectum being the organ representing the maximum contribution of 0.011%.

  16. Electron-photon correlations for e(-)-H(1 2S1/2 - 3 2Pj, 3 2Dj) collisions

    NASA Astrophysics Data System (ADS)

    Katiyar, A. K.; Srivastava, Rajesh

    1987-12-01

    The first theoretical data for the concidence rate N(theta/gamma/, phi/gamma/) between the scattered electrons and photons emitted in the direction (theta/gamma/, phi/gamma/) from the excited 3 2Dj(3 2Pj) states in hydrogen are presented. A consistent version of the distorted-wave Born approximation is used in the calculation. The results show good agreement with the photon coincidence measurements of Chwirot and Slevin (1985, 1987).

  17. The lateral distributions of charged particles of energy greater than 0.3 E sub crit in electron-photon cascades in lead and air

    NASA Technical Reports Server (NTRS)

    Krys, E.; Wasilewski, A.

    1985-01-01

    In recent investigations, both theoretical and experimental, the agreement between cascade theory and experimental data is pointed out. The radial distributions obtained from the Monte Carlo simulation are compared ith the results of the analytical theory for all particles in cascades. The data on the mean radius of electron lateral distribution in air are compared with those in lead.

  18. Monte Carlo study of Siemens PRIMUS photoneutron production

    NASA Astrophysics Data System (ADS)

    Pena, J.; Franco, L.; Gómez, F.; Iglesias, A.; Pardo, J.; Pombar, M.

    2005-12-01

    Neutron production in radiotherapy facilities has been studied from the early days of modern linacs. Detailed studies are now possible using photoneutron capabilities of general-purpose Monte Carlo codes at energies of interest in medical physics. The present work studies the effects of modelling different accelerator head and room geometries on the neutron fluence and spectra predicted via Monte Carlo. The results from the simulation of a 15 MV Siemens PRIMUS linac show an 80% increase in the fluence scored at the isocentre when, besides modelling the components neccessary for electron/photon simulations, other massive accelerator head components are included. Neutron fluence dependence on inner treatment room volume is analysed showing that thermal neutrons have a 'gaseous' behaviour and then a 1/V dependence. Neutron fluence maps for three energy ranges, fast (E > 0.1 MeV), epithermal (1 eV < E < 0.1 MeV) and thermal (E < 1 eV), are also presented and the influence of the head components on them is discussed.

  19. Noninvasive referencing of intraocular tumors for external beam radiation therapy using optical coherence tomography: A proof of concept

    SciTech Connect

    Rüegsegger, Michael B.; Steiner, Patrick; Kowal, Jens H.; Geiser, Dominik; Pica, Alessia; Aebersold, Daniel M.

    2014-08-15

    Purpose: External beam radiation therapy is currently considered the most common treatment modality for intraocular tumors. Localization of the tumor and efficient compensation of tumor misalignment with respect to the radiation beam are crucial. According to the state of the art procedure, localization of the target volume is indirectly performed by the invasive surgical implantation of radiopaque clips or is limited to positioning the head using stereoscopic radiographies. This work represents a proof-of-concept for direct and noninvasive tumor referencing based on anterior eye topography acquired using optical coherence tomography (OCT). Methods: A prototype of a head-mounted device has been developed for automatic monitoring of tumor position and orientation in the isocentric reference frame for LINAC based treatment of intraocular tumors. Noninvasive tumor referencing is performed with six degrees of freedom based on anterior eye topography acquired using OCT and registration of a statistical eye model. The proposed prototype was tested based on enucleated pig eyes and registration accuracy was measured by comparison of the resulting transformation with tilt and torsion angles manually induced using a custom-made test bench. Results: Validation based on 12 enucleated pig eyes revealed an overall average registration error of 0.26 ± 0.08° in 87 ± 0.7 ms for tilting and 0.52 ± 0.03° in 94 ± 1.4 ms for torsion. Furthermore, dependency of sampling density on mean registration error was quantitatively assessed. Conclusions: The tumor referencing method presented in combination with the statistical eye model introduced in the past has the potential to enable noninvasive treatment and may improve quality, efficacy, and flexibility of external beam radiotherapy of intraocular tumors.

  20. Adaptation of telecobalt unit for stereotactic irradiation

    SciTech Connect

    Singh, I. Rabi Raja . E-mail: rabiraja@cmcvellore.ac.in; Ravindran, B. Paul; Ayyangar, K.M.

    2007-04-01

    We investigated the feasibility of using an isocentric telecobalt unit for advanced treatment techniques, such as stereotactic radiotherapy. To adapt the telecobalt unit (Th780 C) for stereotactic irradiation, collimator inserts of various sizes, collimator mount, and a couch mount suitable for the telecobalt unit were developed, and the characteristics of the narrow beams of Cobalt-60 ({sup 60}Co) were studied. Comparative study was carried out between the stereotactic radiotherapy plans of 6 MV and {sup 60}Co beams using a 3-dimensional (3D) treatment planning system. The beam penumbra of {sup 60}Co beams was found to be larger than those of 6 MV beams. The dose-volume histograms (DVH) obtained from the {sup 60}Co beam plan were comparable to those obtained from the 6 MV plan. The DVH of nontarget tissue obtained from the plans of the 2 beams were found to be in good agreement to each other. The difference in equivalent fall-off distance (EFOD) for all 3 cases was found insignificant; hence, it can be concluded that the fall-off dose in the dose distribution of the {sup 60}Co stereotactic plan is as good as that of the 6 MV stereotactic plan. In all 3 cases for which the treatment plans were compared between {sup 60}Co and 6 MV beams, it was observed that the fall-off doses outside the target were similar; therefore, considering {sup 60}Co with 5-mm margin is a cost effective alternative for the linac-based stereotactic radiotherapy.

  1. Quality Assurance Results for a Commercial Radiosurgery System: A Communication.

    PubMed

    Ruschin, Mark; Lightstone, Alexander; Beachey, David; Wronski, Matt; Babic, Steven; Yeboah, Collins; Lee, Young; Soliman, Hany; Sahgal, Arjun

    2015-10-01

    The purpose of this communication is to inform the radiosurgery community of quality assurance (QA) results requiring attention in a commercial FDA-approved linac-based cone stereo-tactic radiosurgery (SRS) system. Standard published QA guidelines as per the American Association of Physics in Medicine (AAPM) were followed during the SRS system's commissioning process including end-to-end testing, cone concentricity testing, image transfer verification, and documentation. Several software and hardware deficiencies that were deemed risky were uncovered during the process and QA processes were put in place to mitigate these risks during clinical practice. In particular, the present work focuses on daily cone concentricity testing and commissioning-related findings associated with the software. Cone concentricity/alignment is measured daily using both optical light field inspection, as well as quantitative radiation field tests with the electronic portal imager. In 10 out of 36 clini-cal treatments, adjustments to the cone position had to be made to align the cone with the collimator axis to less than 0.5 mm and on two occasions the pre-adjustment measured offset was 1.0 mm. Software-related errors discovered during commissioning included incorrect transfer of the isocentre in DICOM coordinates, improper handling of non-axial image sets, and complex handling of beam data, especially for multi-target treatments. QA processes were established to mitigate the occurrence of the software errors. With proper QA processes, the reported SRS system complies with tolerances set out in established guidelines. Discussions with the vendor are ongoing to address some of the hardware issues related to cone alignment. PMID:24945371

  2. Terrestrial gamma ray flashes from electron avalanches in thunderstorms - the detailed structure and time evolution of electron, photon, optical and radio emission - results from a new simulation software package

    NASA Astrophysics Data System (ADS)

    Connell, P. H.

    2013-12-01

    To design the MXGS coded mask imager of the ASIM mission to the ISS, to detect and locate TGF gamma-rays, a first order software package was written at UV to simulate the vertical expansion of gamma-ray photons from 15-20 km altitudes up to 300-600 km orbital altitudes, to make some estimate of the probable TGF spectra and diffuse beam structure that might be observed by MXGS. A new software package includes the simulation of the Runaway Electron Avalanche (REA) origin of TGFs by electron ionization and Bremsstrahlung scattering and photon emission. It uses the standard KeV-MeV scattering physics of electron and photon interactions, close range Moller electron ionization, Binary-Electron-Bethe models of electron scattering, positron Bhabha scattering and annihilation, electron excitation and photon emission. It also uses a super particle spatial mesh system to control particle-momentum flux densities, electric field evolution and exponential avalanche growth and falloff. The package takes care of all high energy scattering physics, leaving the user free to concentrate on defining the three components of scattering medium, electric-magnetic field geometry, and free electron flux field geometry whose details are the main unknown in TGF research. Results will be presented from TGF simulations using realistic electric fields expected within and above storm clouds, and will include video displays showing the evolving ionization structure of electron trajectories, the time evolution of photon flux fields, electron-positron flux fields, their important circular feedback movement in the local earth magnetic field, local molecular ion densities, and the dielectric effect of induced local electric fields. The second aim of the package is as a step in creating open source software which could evolve into a standard research software package approved by the REA-TGF research community to correctly simulate all the relevant physical processes involved in the complex phenomenon of REA in thunderstorms. TGF photon expansion in stratosphere TGF photon expansion to orbital altitudes

  3. Neutron Spectra and H*(10) in a 15 MV Linac

    SciTech Connect

    Benites, J.; Vega-Carrillo, H. R.; Hernandez-Davila, V. M.; Rivera, T.; Carrillo, A.; Mondragon, R.

    2010-12-07

    Neutron spectra and the ambient dose equivalent were calculated inside the bunker of a 15 MV Varian linac model CLINAC iX. Calculations were carried out using Monte Carlo methods. Neutron spectra in the vicinity of isocentre show the presence of evaporation and knock-on neutrons produced by the source term, while epithermal and thermal neutron remain constant regardless the distance respect to isocentre, due to room return. Along the maze neutron spectra becomes softer as the detector moves along the maze. The ambient dose equivalent is decreased but do not follow the 1/r{sup 2} rule due to changes in the neutron spectra.

  4. SUPERCONDUCTING NON-SCALING FFAG GANTRY FOR CARBON-PROTON CANCER THERAPY

    SciTech Connect

    TRBOJEVIC,D.; GUPTA, R.; PARKER, B.; KEIL, E.; SESSLER, A.M.

    2007-06-25

    We report on improvements in the non-scaling Fixed Field Alternating Gradient (FFAG) gantry design. As we previously reported, a major challenge of the carbodproton cancer therapy facilities is isocentric gantry design. The weight of the isocentric gantry transport elements in the latest Heidelberg carbon/proton facility is 135 tons. In this report we detail improvements to the previous non-scaling gantry design. We estimate that this non-scaling FFAG gantry would be almost hundred times lighter than traditional heavy ion gantries. Very strong focusing with small dispersion permits passage of different energies of carbon beams through the gantry's fixed magnetic field.

  5. PRELIMINARY COMMUNICATION: Abutment region dosimetry for sequential arc IMRT delivery

    NASA Astrophysics Data System (ADS)

    Low, Daniel A.; Mutic, Sasa

    1997-07-01

    Arc-based intensity modulated radiation therapy (IMRT) planning and delivery is available as a commercial product (Nomos Corp.). The dose distribution is delivered to 1.68 cm thick regions, and the patient moved in a precise manner between treatments. Assuming accurate patient positioning, the abutment region dose distribution near the gantry isocentre is delivered with no undesired dose heterogeneities. However, for regions far from the isocentre, the dose distribution may exhibit high- or low-dose regions due to uncompensated beam divergence for arc treatments of less than gantry angle length. A study has been initiated to characterize abutment region dose distribution heterogeneities for sequential arc IMRT delivery. Five dose distributions were optimized, each using 8 cm diameter target volumes at different distances from the isocentre, and the arc delivery limited to symmetric about the vertical axis. The target lengths were sufficient to require a treatment consisting of five couch positions, yielding four abutment regions. The dose within the abutment regions was measured using film and analysed as a function of off-axis position along both the vertical and horizontal directions. Little dependence on the dose heterogeneity was seen along the horizontal axis passing through the isocentre. However, the abutment regions along the vertical axis contained 15% low and 7% high doses at 7 cm above and below the isocentre respectively. This dose heterogeneity is not predicted by the current clinical release of the treatment planning software due to limitations of the dose calculation algorithm. The intensity of dose heterogeneity is considered sufficient to warrant further study.

  6. Photon-Electron Interaction and Condense Beams

    SciTech Connect

    Chattopadhyay, S.

    1998-11-01

    We discuss beams of charged particles and radiation from multiple perspectives. These include fundamental acceleration and radiation mechanisms, underlying electron-photon interaction, various classical and quantum phase-space concepts and fluctuational interpretations.

  7. Overview of the Defense Programs Research and Technology Development Program for Fiscal Year 1993

    SciTech Connect

    Not Available

    1993-09-30

    This documents presents a programmatic overview and program element plan summaries for conceptual design and assessment; physics; computation and modeling; system engineering science and technology; electronics, photonics, sensors, and mechanical components; chemistry and materials; special nuclear materials, tritium, and explosives.

  8. SU-E-T-376: 3-D Commissioning for An Image-Guided Small Animal Micro- Irradiation Platform

    SciTech Connect

    Qian, X; Wuu, C; Admovics, J

    2014-06-01

    Purpose: A 3-D radiochromic plastic dosimeter has been used to cross-test the isocentricity of a high resolution image-guided small animal microirradiation platform. In this platform, the mouse stage rotating for cone beam CT imaging is perpendicular to the gantry rotation for sub-millimeter radiation delivery. A 3-D dosimeter can be used to verify both imaging and irradiation coordinates. Methods: A 3-D dosimeter and optical CT scanner were used in this study. In the platform, both mouse stage and gantry can rotate 360° with rotation axis perpendicular to each other. Isocentricity and coincidence of mouse stage and gantry rotations were evaluated using star patterns. A 3-D dosimeter was placed on mouse stage with center at platform isocenter approximately. For CBCT isocentricity, with gantry moved to 90°, the mouse stage rotated horizontally while the x-ray was delivered to the dosimeter at certain angles. For irradiation isocentricity, the gantry rotated 360° to deliver beams to the dosimeter at certain angles for star patterns. The uncertainties and agreement of both CBCT and irradiation isocenters can be determined from the star patterns. Both procedures were repeated 3 times using 3 dosimeters to determine short-term reproducibility. Finally, dosimeters were scanned using optical CT scanner to obtain the results. Results: The gantry isocentricity is 0.9 ± 0.1 mm and mouse stage rotation isocentricity is about 0.91 ± 0.11 mm. Agreement between the measured isocenters of irradiation and imaging coordinates was determined. The short-term reproducibility test yielded 0.5 ± 0.1 mm between the imaging isocenter and the irradiation isocenter, with a maximum displacement of 0.7 ± 0.1 mm. Conclusion: The 3-D dosimeter can be very useful in precise verification of targeting for a small animal irradiation research. In addition, a single 3-D dosimeter can provide information in both geometric and dosimetric uncertainty, which is crucial for translational studies.

  9. The non-orthogonal fixed beam arrangement for the second proton therapy facility at the National Accelerator Center

    NASA Astrophysics Data System (ADS)

    Schreuder, A. N.; Jones, D. T. L.; Conradie, J. L.; Fourie, D. T.; Botha, A. H.; Müller, A.; Smit, H. A.; O'Ryan, A.; Vernimmen, F. J. A.; Wilson, J.; Stannard, C. E.

    1999-06-01

    The medical user group at the National Accelerator Center (NAC) is currently unable to treat all eligible patients with high energy protons. Developing a second proton treatment room is desirable since the 200 MeV proton beam from the NAC separated sector cyclotron is currently under-utilized during proton therapy sessions. During the patient positioning phase in one treatment room, the beam could be used for therapy in a second room. The second proton therapy treatment room at the NAC will be equipped with two non-orthogonal beam lines, one horizontal and one at 30 degrees to the vertical. The two beams will have a common isocentre. This beam arrangement together with a versatile patient positioning system (commercial robot arm) will provide the radiation oncologist with a diversity of possible beam arrangements and offers a reasonable cost-effective alternative to an isocentric gantry.

  10. The non-orthogonal fixed beam arrangement for the second proton therapy facility at the National Accelerator Center

    SciTech Connect

    Schreuder, A. N.; Jones, D. T. L.; Conradie, J. L.; Fourie, D. T.; Botha, A. H.; Mueller, A.; Smit, H. A.; O'Ryan, A.; Vernimmen, F. J. A.; Wilson, J.; Stannard, C. E.

    1999-06-10

    The medical user group at the National Accelerator Center (NAC) is currently unable to treat all eligible patients with high energy protons. Developing a second proton treatment room is desirable since the 200 MeV proton beam from the NAC separated sector cyclotron is currently under-utilized during proton therapy sessions. During the patient positioning phase in one treatment room, the beam could be used for therapy in a second room. The second proton therapy treatment room at the NAC will be equipped with two non-orthogonal beam lines, one horizontal and one at 30 degrees to the vertical. The two beams will have a common isocentre. This beam arrangement together with a versatile patient positioning system (commercial robot arm) will provide the radiation oncologist with a diversity of possible beam arrangements and offers a reasonable cost-effective alternative to an isocentric gantry.

  11. Computer-aided design optimization with the use of a fast dose model for linear-accelerator-based stereotactic radiosurgery

    NASA Astrophysics Data System (ADS)

    Suh, Tae S.; Bova, Frank J.; Yoon, Sei C.; Choe, Bo Y.; Kim, Moon C.; Shinn, Kyung S.; Bahk, Yong W.; Ha, Sung W.; Park, Charn I.

    1996-04-01

    In order to efficiently plan non-spherical radiosurgical targets we have used computer-aided design optimization techniques with a fast dose model. A study of the spatial dose distribution for single or multiple non-coplanar arcs was carried out using a 18 cm diameter spherical head model. The dose distribution generated from the 3D dose computation algorithm can be represented by a simple analytic form. Two analytic dose models were developed to represent the dose for preset multiple non-coplanar arcs or a single arc: spherical and cylindrical. The spherical and cylindrical dose models compute dose quickly for each isocentre and single arc. Our approach then utilizes a computer-aided design optimization (CAD) with the use of two fast approximate dose models to determine the positions of isocentres and arcs. The implementation of CAD with fast dose models was demonstrated. While the fast dose models are only approximations of the true dose distribution, it is shown that this approximate model is sufficient to optimize isocentric position, collimator size and arc positions with CAD.

  12. Volume Changes After Stereotactic LINAC Radiotherapy in Vestibular Schwannoma: Control Rate and Growth Patterns

    SciTech Connect

    Langenberg, Rick van de; Dohmen, Amy J.C.; Bondt, Bert J. de; Nelemans, Patty J.; Baumert, Brigitta G.; Stokroos, Robert J.

    2012-10-01

    Purpose: The purpose of this study was to evaluate the control rate of vestibular schwannomas (VS) after treatment with linear accelerator (LINAC)-based stereotactic radiosurgery (SRS) or radiotherapy (SRT) by using a validated volumetric measuring tool. Volume-based studies on prognosis after LINAC-based SRS or SRT for VS are reported scarcely. In addition, growth patterns and risk factors predicting treatment failure were analyzed. Materials and Methods: Retrospectively, 37 VS patients treated with LINAC based SRS or SRT were analyzed. Baseline and follow-up magnetic resonance imaging scans were analyzed with volume measurements on contrast enhanced T1-weighted magnetic resonance imaging. Absence of intervention after radiotherapy was defined as 'no additional intervention group, ' absence of radiological growth was defined as 'radiological control group. ' Significant growth was defined as a volume change of 19.7% or more, as calculated in a previous study. Results: The cumulative 4-year probability of no additional intervention was 96.4% {+-} 0.03; the 4-year radiological control probability was 85.4% {+-} 0.1). The median follow-up was 40 months. Overall, shrinkage was seen in 65%, stable VS in 22%, and growth in 13%. In 54% of all patients, transient swelling was observed. No prognostic factors were found regarding VS growth. Previous treatment and SRS were associated with transient swelling significantly. Conclusions: Good control rates are reported for LINAC based SRS or SRT in VS, in which the lower rate of radiological growth control is attributed to the use of the more sensitive volume measurements. Transient swelling after radiosurgery is a common phenomenon and should not be mistaken for treatment failure. Previous treatment and SRS were significantly associated with transient swelling.

  13. Spallation neutron source and other high intensity froton sources

    SciTech Connect

    Weiren Chou

    2003-02-06

    This lecture is an introduction to the design of a spallation neutron source and other high intensity proton sources. It discusses two different approaches: linac-based and synchrotron-based. The requirements and design concepts of each approach are presented. The advantages and disadvantages are compared. A brief review of existing machines and those under construction and proposed is also given. An R&D program is included in an appendix.

  14. Automated treatment planning for a dedicated multi-source intra-cranial radiosurgery treatment unit accounting for overlapping structures and dose homogeneity

    SciTech Connect

    Ghobadi, Kimia; Ghaffari, Hamid R.; Aleman, Dionne M.; Jaffray, David A.; Ruschin, Mark

    2013-09-15

    Purpose: The purpose of this work is to advance the two-step approach for Gamma Knife{sup ®} Perfexion™ (PFX) optimization to account for dose homogeneity and overlap between the planning target volume (PTV) and organs-at-risk (OARs).Methods: In the first step, a geometry-based algorithm is used to quickly select isocentre locations while explicitly accounting for PTV-OARs overlaps. In this approach, the PTV is divided into subvolumes based on the PTV-OARs overlaps and the distance of voxels to the overlaps. Only a few isocentres are selected in the overlap volume, and a higher number of isocentres are carefully selected among voxels that are immediately close to the overlap volume. In the second step, a convex optimization is solved to find the optimal combination of collimator sizes and their radiation duration for each isocentre location.Results: This two-step approach is tested on seven clinical cases (comprising 11 targets) for which the authors assess coverage, OARs dose, and homogeneity index and relate these parameters to the overlap fraction for each case. In terms of coverage, the mean V{sub 99} for the gross target volume (GTV) was 99.8% while the V{sub 95} for the PTV averaged at 94.6%, thus satisfying the clinical objectives of 99% for GTV and 95% for PTV, respectively. The mean relative dose to the brainstem was 87.7% of the prescription dose (with maximum 108%), while on average, 11.3% of the PTV overlapped with the brainstem. The mean beam-on time per fraction per dose was 8.6 min with calibration dose rate of 3.5 Gy/min, and the computational time averaged at 205 min. Compared with previous work involving single-fraction radiosurgery, the resulting plans were more homogeneous with average homogeneity index of 1.18 compared to 1.47.Conclusions: PFX treatment plans with homogeneous dose distribution can be achieved by inverse planning using geometric isocentre selection and mathematical modeling and optimization techniques. The quality of the

  15. Robust frameless stereotactic localization in extra-cranial radiotherapy

    SciTech Connect

    Riboldi, Marco; Baroni, Guido; Spadea, Maria Francesca; Bassanini, Fabio; Tagaste, Barbara; Garibaldi, Cristina; Orecchia, Roberto; Pedotti, Antonio

    2006-04-15

    In the field of extra-cranial radiotherapy, several inaccuracies can make the application of frameless stereotactic localization techniques error-prone. When optical tracking systems based on surface fiducials are used, inter- and intra-fractional uncertainties in marker three-dimensional (3D) detection may lead to inexact tumor position estimation, resulting in erroneous patient setup. This is due to the fact that external fiducials misdetection results in deformation effects that are poorly handled in a rigid-body approach. In this work, the performance of two frameless stereotactic localization algorithms for 3D tumor position reconstruction in extra-cranial radiotherapy has been specifically tested. Two strategies, unweighted versus weighted, for stereotactic tumor localization were examined by exploiting data coming from 46 patients treated for extra-cranial lesions. Measured isocenter displacements and rotations were combined to define isocentric procedures, featuring 6 degrees of freedom, for correcting patient alignment (isocentric positioning correction). The sensitivity of the algorithms to uncertainties in the 3D localization of fiducials was investigated by means of 184 numerical simulations. The performance of the implemented isocentric positioning correction was compared to conventional point-based registration. The isocentric positioning correction algorithm was tested on a clinical dataset of inter-fractional and intra-fractional setup errors, which was collected by means of an optical tracker on the same group of patients. The weighted strategy exhibited a lower sensitivity to fiducial localization errors in simulated misalignments than those of the unweighted strategy. Isocenter 3D displacements provided by the weighted strategy were consistently smaller than those featured by the unweighted strategy. The peak decrease in median and quartile values of isocenter 3D displacements were 1.4 and 2.7 mm, respectively. Concerning clinical data, the

  16. Calculation of the radio emission from EAS

    NASA Technical Reports Server (NTRS)

    Allan, H. R.; Sun, M. P.; Crannell, C. J.; Hough, J. H.; Shutie, P. F.

    1975-01-01

    Time-varying features of an electron-photon cascade are considered, particularly those associated with radio emission. The cosmic ray shower is represented as a superposition of collinear 10 GeV electron-photon cascades launched at different heights in the atmosphere. Actual simulations are performed for only 10 cascades at each of 40 heights and the results are scaled to represent the total number of cascades required. The apparent angular motions of the cascade particles as detected by antennas located at various positions up to 300 m from the shower axis are simulated. The radio pulse waveform and the corresponding frequency spectrum are obtained from these motions.

  17. Dissipationless electron transport in photon-dressed nanostructures.

    PubMed

    Kibis, O V

    2011-09-01

    It is shown that the electron coupling to photons in field-dressed nanostructures can result in the ground electron-photon state with a nonzero electric current. Since the current is associated with the ground state, it flows without the Joule heating of the nanostructure and is nondissipative. Such a dissipationless electron transport can be realized in strongly coupled electron-photon systems with the broken time-reversal symmetry--particularly, in quantum rings and chiral nanostructures dressed by circularly polarized photons. PMID:21981519

  18. A PEDA approach for monolithic photonic BiCMOS technologies

    NASA Astrophysics Data System (ADS)

    Simon, Stefan; Winzer, Georg; Roßmann, Helmut; Kroh, Marcel; Zimmermann, Lars; Mausolf, Thomas

    2015-06-01

    The paper describes a novel approach to photonic electronic design automation (PEDA) based on the commercial design suite Laytools for circuit and physical layout design and simulation. The goal of this work is the integration of an electronic-photonic design flow into an existing electronic design automation (EDA) tool. Contrary to other solutions, with this approach, it is possible to minimize the required interfaces to other third party tools. In addition to existing electronic device models, photonic components are described with behavioral models. The mask layout has been extended to the needs of the electronic photonic integrated circuit (ePIC) designer and the verification flow was adapted to the photonic structures.

  19. Hybrid photoneutron source optimization for electron accelerator-based BNCT

    NASA Astrophysics Data System (ADS)

    Rahmani, F.; Shahriari, M.

    2010-06-01

    Boron Neutron Capture Therapy (BNCT) is being studied as a possible radiotherapic treatment for some cancer types. Neutron energy for penetrating into tissue should be in the epithermal range. Different methods are used for neutron production. Electron accelerators are an alternative way for producing neutrons in electron-photon-neutron processes. Optimization of electron/photon and photoneutron targets calculations with respect to electron energy, dimension (radius and thickness) and neutron yield were done by MCNPX Monte Carlo code. According to the results, a hybrid photoneutron source including BeD 2 and Tungsten has been introduced.

  20. Comparison of big event with calculations of the air shower development

    NASA Technical Reports Server (NTRS)

    Niwa, M.; Misaki, A.; Matano, T.

    1985-01-01

    The incidence of high energy hadrons and electron-photons in air showers at various stages of development is calculated. Numerical calculation is used to solve the diffusion equation for a nuclear cascade and analytical calculation for cascade shower induced gamma rays. From these calculations, one can get the longitudinal development of the high energy hadron and electron-photon components, and the energy spectra of these components at various depths of air shower development. The total number of hadrons (N sub H) and electron-photon components (N sub gamma) are related according to stages of the air shower development and primary energy. The relation of the total energy of hadron and electron-photon component above the threshold energy is given. The energy balance between both components is also a useful parameter to study high energy events accompanying air showers. The relation of N sub H and fractional hadronic energy E (sum E sub H sup gamma/sum E sub H sup gamma + Sum E sub gamma) is calculated. This relation is helpful to understand the stage of air shower development(t) and primary energy (E sub p).

  1. The EPRDATA Format: A Dialogue

    SciTech Connect

    Hughes, III, Henry Grady

    2015-08-18

    Recently the Los Alamos Nuclear Data Team has communicated certain issues of concern in relation to the new electron/photon/relaxation ACE data format as released in the eprdata12 library. In this document those issues are parsed, analyzed, and answered.

  2. 23 CFR 771.117 - Categorical exclusions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... actions which meet the definition contained in 40 CFR 1508.4, and, based on past experience with similar.... (20) Promulgation of rules, regulations, and directives. (21) Deployment of electronics, photonics.... (d) Additional actions which meet the criteria for a CE in the CEQ regulations (40 CFR 1508.4)...

  3. Improved geometry representations for Monte Carlo radiation transport.

    SciTech Connect

    Martin, Matthew Ryan

    2004-08-01

    ITS (Integrated Tiger Series) permits a state-of-the-art Monte Carlo solution of linear time-integrated coupled electron/photon radiation transport problems with or without the presence of macroscopic electric and magnetic fields of arbitrary spatial dependence. ITS allows designers to predict product performance in radiation environments.

  4. Design certification review assessment report. Electron/proton spectrometer

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The characteristics of the electron-photon spectrometer developed for the Skylab program are presented. The spectrometer is externally mounted on the Skylab module complex and provides omnidirectional measurement of electrons and protons which result from solar flares or enhancement of the radiation belts. The data are applied to the determination of relative biological effectiveness factors as a safety factor for manned space flight.

  5. Photon and electron collimator effects on electron output and abutting segments in energy modulated electron therapy

    SciTech Connect

    Olofsson, Lennart; Karlsson, Magnus G.; Karlsson, Mikael

    2005-10-15

    In energy modulated electron therapy a large fraction of the segments will be arranged as abutting segments where inhomogeneities in segment matching regions must be kept as small as possible. Furthermore, the output variation between different segments should be minimized and must in all cases be well predicted. For electron therapy with add-on collimators, both the electron MLC (eMLC) and the photon MLC (xMLC) contribute to these effects when an xMLC tracking technique is utilized to reduce the x-ray induced leakage. Two add-on electron collimator geometries have been analyzed using Monte Carlo simulations: One isocentric eMLC geometry with an isocentric clearance of 35 cm and air or helium in the treatment head, and one conventional proximity geometry with a clearance of 5 cm and air in the treatment head. The electron fluence output for 22.5 MeV electrons is not significantly affected by the xMLC if the shielding margins are larger than 2-3 cm. For small field sizes and 9.6 MeV electrons, the isocentric design with helium in the treatment head or shielding margins larger than 3 cm is needed to avoid a reduced electron output. Dose inhomogeneity in the matching region of electron segments is, in general, small when collimator positions are adjusted to account for divergence in the field. The effect of xMLC tracking on the electron output can be made negligible while still obtaining a substantially reduced x-ray leakage contribution. Collimator scattering effects do not interfere significantly when abutting beam techniques are properly applied.

  6. Pilot study on interfractional and intrafractional movements using surface infrared markers and EPID for patients with rectal cancer treated in the prone position

    PubMed Central

    Eom, K-Y; Kim, K; Chang, J H; Koo, T R; Park, J I; Park, Y-G; Ye, S-J; Ha, S W

    2015-01-01

    Objective: To evaluate interfractional and intrafractional movement of patients with rectal cancer during radiotherapy with electronic portal imaging device (EPID) and surface infrared (IR) markers. Methods: 20 patients undergoing radiotherapy for rectal cancer with body mass index ranging from 18.5 to 30 were enrolled. Patients were placed in the prone position on a couch with a leg pillow. Three IR markers were put on the surface of each patient and traced by two stereo cameras during radiotherapy on a twice-weekly basis. Interfractional isocentre movement was obtained with EPID images on a weekly basis. Movement of the IR markers was analysed in correlation with the isocentre movement obtained from the EPID images. Results: The maximum right-to-left (R-L) movement of the laterally located markers in the horizontal isocentre plane was correlated with isocentre translocation with statistical significance (p = 0.018 and 0.015, respectively). Movement of the surface markers was cyclical. For centrally located markers, the 95% confidence intervals for the average amplitude in the R-L, cranial-to-caudal (C-C) and anterior-to-posterior (A-P) directions were 0.86, 2.25 and 3.48 mm, respectively. In 10 patients, intrafractional movement exceeding 5 mm in at least one direction was observed. Time-dependent systematic movement of surface markers during treatment, which consisted of continuous movement towards the cranial direction and a sail back motion in the A-P direction, was also observed. Conclusion: Intrafractional movement of surface markers has both cyclic components and time-dependent systematic components. Marker deviations exceeding 5 mm were mainly seen in the A-P direction. Pre- or post-treatment EPID images may not provide adequate information regarding intrafractional movement because of systematic movement in the A-P direction during radiotherapy. Advances in knowledge: This work uncovered a sail back motion of patients in the A-P direction during

  7. Physical considerations in the treatment of advanced carcinomas of the larynx and pyriform sinuses using 10 MV x rays

    SciTech Connect

    Doppke, K.; Novack, D.; Wang, C.C.

    1980-09-01

    A technique for treating patients who have advanced tumors of the larynx and pyriform sinus was developed using isocentric anterior and posterior opposed fields with 10 MV x rays. This technique can be used to deliver a tumor dose of 45 Gray to the primary site and regional nodes and approximately 40 Gray to the spinal cord. The method eliminates problems of multi-field junctures and lowers the daily spinal cord dose when compared to the standard parallel opposed lateral portals and anterior neck fields.

  8. Digital tomosynthesis: technique modifications and clinical applications for neurovascular anatomy

    SciTech Connect

    Maravilla, K.R.; Murry, R.C. Jr.; Diehl, J.; Suss, R.; Allen, L.; Chang, K.; Crawford, J.; McCoy, R.

    1984-09-01

    Digital tomosynthesis studies (DTS) using a linear tomographic motion can provide good quality clinical images when combined with subtraction angiotomography. By modifying their hardware system and the computer software algorithms, the authors were able to reconstruct tomosynthesis images using an isocentric rotation (IR) motion. Applying a combination of linear tomographic and IR techniques in clinical cases, they performed DTS studies in six patients, five with aneurysms and one with a hypervascular tumor. The results showed detailed definitions of the pathologic entities and the regional neurovascular anatomy. Based on this early experience, DTS would seem to be a useful technique for the preoperative surgical planning of vascular abnormalities.

  9. Intensity-modulated radiation therapy (IMRT) dosimetry of the head and neck: A comparison of treatment plans using linear accelerator-based IMRT and helical tomotherapy

    SciTech Connect

    Sheng Ke . E-mail: ks2mc@virginia.edu; Molloy, Janelle A.; Read, Paul W.

    2006-07-01

    Purpose: To date, most intensity-modulated radiation therapy (IMRT) delivery has occurred using linear accelerators (linacs), although helical tomotherapy has become commercially available. To quantify the dosimetric difference, we compared linac-based and helical tomotherapy-based treatment plans for IMRT of the oropharynx. Methods and Materials: We compared the dosimetry findings of 10 patients who had oropharyngeal carcinoma. Five patients each had cancers in the base of the tongue and tonsil. Each plan was independently optimized using either the CORVUS planning system (Nomos Corporation, Sewickly, PA), commissioned for a Varian 2300 CD linear accelerator (Varian Medical Systems, Palo Alto, CA) with 1-cm multileaf collimator leaves, or helical tomotherapy. The resulting treatment plans were evaluated by comparing the dose-volume histograms, equivalent uniform dose (EUD), dose uniformity, and normal tissue complication probabilities. Results: Helical tomotherapy plans showed improvement of critical structure avoidance and target dose uniformity for all patients. The average equivalent uniform dose reduction for organs at risk (OARs) surrounding the base of tongue and the tonsil were 17.4% and 27.14% respectively. An 80% reduction in normal tissue complication probabilities for the parotid glands was observed in the tomotherapy plans relative to the linac-based plans. The standard deviation of the planning target volume dose was reduced by 71%. In our clinic, we use the combined dose-volume histograms for each class of plans as a reference goal for helical tomotherapy treatment planning optimization. Conclusions: Helical tomotherapy provides improved dose homogeneity and normal structure dose compared with linac-based IMRT in the treatment of oropharyngeal carcinoma resulting in a reduced risk for complications from focal hotspots within the planning target volume and for the adjacent parotid glands.

  10. Helical Tomotherapy of Nasopharyngeal Carcinoma-Any Advantages Over Conventional Intensity-Modulated Radiotherapy?

    SciTech Connect

    Wu, W.C. Vincent Mui, Wing-lun A.; Fung, Wing-ki W.

    2010-07-01

    Helical tomotherapy uses different planning algorithm and dose delivery method from the linear accelerator (linac)-based intensity-modulated radiotherapy (IMRT). This study compared the dosimetric outcomes between the tomotherapy plans and conventional linac-based IMRT plans in the treatment of nasopharyngeal carcinoma (NPC). Fifteen stage II-III cancer (American Joint Committee on Cancer) NPC patients treated by tomotherapy were conveniently recruited. Apart from the tomotherapy plans, a 7-field 6-MV photon conventional IMRT plan was computed for each patient with the same CT dataset and reference from the dose constraints and target dose prescriptions of the tomotherapy plans using the XiO treatment planning system. Average values of the dose parameters including the conformity index (CI), homogeneity index (HI), maximum and minimum doses of the target volumes, and the maximum and mean doses of the organs at risk (OAR) were compared between the two treatment methods. Better dose coverage of the planning target volume (PTV) was demonstrated in the tomotherapy plans, in which the differences in the maximum and mean doses reached statistical significance (p < 0.05). Besides, the CI of the tomotherapy plans were significantly higher than the conventional linac-based plans for the nasopharynx PTV (NP-PTV) and neck lymphatics PTV (LN-PTV) (p = 0.017 and 0.010, respectively). The HI was significantly smaller in both NP-PTV and LN-PTV (p = 0.024 and < 0.001, respectively). Among the OAR, the brain stem and spinal cord doses in the tomotherapy plans were lower than that of the conventional IMRT plans. However, the doses to the other OAR did not show significant dosimetric differences. In the treatment of nasopharyngeal carcinoma, tomotherapy plans were superior to the 7-field conventional IMRT plans in PTV dose conformity and homogeneity and the sparing of the brain stem and spinal cord. However, no significant advantages were observed for the rest of the OAR.

  11. Hippocampal-Sparing Whole-Brain Radiotherapy: A 'How-To' Technique Using Helical Tomotherapy and Linear Accelerator-Based Intensity-Modulated Radiotherapy

    SciTech Connect

    Gondi, Vinai; Tolakanahalli, Ranjini; Mehta, Minesh P.; Tewatia, Dinesh; Rowley, Howard; Kuo, John S.; Khuntia, Deepak; Tome, Wolfgang A.

    2010-11-15

    Purpose: Sparing the hippocampus during cranial irradiation poses important technical challenges with respect to contouring and treatment planning. Herein we report our preliminary experience with whole-brain radiotherapy using hippocampal sparing for patients with brain metastases. Methods and Materials: Five anonymous patients previously treated with whole-brain radiotherapy with hippocampal sparing were reviewed. The hippocampus was contoured, and hippocampal avoidance regions were created using a 5-mm volumetric expansion around the hippocampus. Helical tomotherapy and linear accelerator (LINAC)-based intensity-modulated radiotherapy (IMRT) treatment plans were generated for a prescription dose of 30 Gy in 10 fractions. Results: On average, the hippocampal avoidance volume was 3.3 cm{sup 3}, occupying 2.1% of the whole-brain planned target volume. Helical tomotherapy spared the hippocampus, with a median dose of 5.5 Gy and maximum dose of 12.8 Gy. LINAC-based IMRT spared the hippocampus, with a median dose of 7.8 Gy and maximum dose of 15.3 Gy. On a per-fraction basis, mean dose to the hippocampus (normalized to 2-Gy fractions) was reduced by 87% to 0.49 Gy{sub 2} using helical tomotherapy and by 81% to 0.73 Gy{sub 2} using LINAC-based IMRT. Target coverage and homogeneity was acceptable with both IMRT modalities, with differences largely attributed to more rapid dose fall-off with helical tomotherapy. Conclusion: Modern IMRT techniques allow for sparing of the hippocampus with acceptable target coverage and homogeneity. Based on compelling preclinical evidence, a Phase II cooperative group trial has been developed to test the postulated neurocognitive benefit.

  12. ELECTRON BEAM ION SOURCE PREINJECTOR PROJECT (EBIS) CONCEPTUAL DESIGN REPORT.

    SciTech Connect

    ALESSI, J.; BARTON, D.; BEEBE, E.; GASSNER, D.; ET AL.

    2005-02-28

    This report describes a new heavy ion pre-injector for the Relativistic Heavy Ion Collider (RHIC) based on a high charge state Electron Beam Ion Source (EBIS), a Radio Frequency Quadrupole (RFQ) accelerator, and a short Linac. The highly successful development of an EBIS at BNL now makes it possible to replace the present pre-injector that is based on an electrostatic Tandem with a reliable, low maintenance Linac-based pre-injector. Linac-based pre-injectors are presently used at most accelerator and collider facilities with the exception of RHIC, where the required gold beam intensities could only be met with a Tandem until the recent EBIS development. EBIS produces high charge state ions directly, eliminating the need for the two stripping foils presently used with the Tandem. Unstable stripping efficiencies of these foils are a significant source of luminosity degradation in RHIC. The high reliability and flexibility of the new Linac-based pre-injector will lead to increased integrated luminosity at RHIC and is an essential component for the long-term success of the RHIC facility. This new pre-injector, based on an EBIS, also has the potential for significant future intensity increases and can produce heavy ion beams of all species including uranium beams and, as part of a future upgrade, might also be used to produce polarized {sup 3}He beams. These capabilities will be critical to the future luminosity upgrades and electron-ion collisions in RHIC. The new RFQ and Linac that are used to accelerate beams from the EBIS to an energy sufficient for injection into the Booster are both very similar to existing devices already in operation at other facilities. Injection into the Booster will occur at the same location as the existing injection from the Tandem.

  13. The 4th Generation Light Source at Jefferson Lab

    SciTech Connect

    Stephen Benson; George Biallas; James Boyce; Donald Bullard; James Coleman; David Douglas; H. Dylla; Richard Evans; Pavel Evtushenko; Albert Grippo; Christopher Gould; Joseph Gubeli; David Hardy; Carlos Hernandez-Garcia; Kevin Jordan; John Klopf; Steven Moore; George Neil; Thomas Powers; Joseph Preble; Daniel Sexton; Michelle D. Shinn; Christopher Tennant; Richard Walker; Shukui Zhang; Gwyn Williams

    2007-04-25

    A number of "Grand Challenges" in Science have recently been identified in reports from The National Academy of Sciences, and the U.S. Dept. of Energy, Basic Energy Sciences. Many of these require a new generation of linac-based light source to study dynamical and non-linear phenomena in nanoscale samples. In this paper we present a summary of the properties of such light sources, comparing them with existing sources, and then describing in more detail a specific source at Jefferson Lab. Importantly, the JLab light source has developed some novel technology which is a critical enabler for other new light sources.

  14. Development of 325 MHz single spoke resonators at Fermilab

    SciTech Connect

    Apollinari, G.; Gonin, I.V.; Khabiboulline, T.N.; Lanfranco, G.; Mukherjee, A.; Ozelis, J.; Ristori, L.; Sergatskov, D.; Wagner, R.; Webber, R.; /Fermilab

    2008-08-01

    The High Intensity Neutrino Source (HINS) project represents the current effort at Fermilab to produce an 8-GeV proton linac based on 400 independently phased superconducting cavities. Eighteen ?=0.21 single spoke resonators, operating at 325 MHz, comprise the first stage of the linac cold section. In this paper we present the current status of the production and testing of the first two prototype cavities. This includes descriptions of the fabrication, frequency tuning, chemical polishing, high pressure rinse, and high-gradient cold tests.

  15. Thermal neutron cross section of liquid and solid mesitylene

    NASA Astrophysics Data System (ADS)

    Cantargi, F.; Blostein, J. J.; Torres, L.; Granada, J. R.

    2006-08-01

    Total cross sections of mesitylene at 293 K and at 89 K were measured at the electron LINAC based pulsed neutron source of Centro Atómico Bariloche. Preliminary frequency spectra were proposed for liquid and solid mesitylene at those temperatures combining experimental and synthetic contributions. Scattering law data files were generated with the NJOY nuclear data processing system. Good agreement between experiments and calculations is found, which represents a primary validation of the scattering kernels which are now being used for the design and optimization of a cold moderator employing that material.

  16. Simultaneous optimization of the cavity heat load and trip rates in linacs using a genetic algorithm

    NASA Astrophysics Data System (ADS)

    Terzić, Balša; Hofler, Alicia S.; Reeves, Cody J.; Khan, Sabbir A.; Krafft, Geoffrey A.; Benesch, Jay; Freyberger, Arne; Ranjan, Desh

    2014-10-01

    In this paper, a genetic algorithm-based optimization is used to simultaneously minimize two competing objectives guiding the operation of the Jefferson Lab's Continuous Electron Beam Accelerator Facility linacs: cavity heat load and radio frequency cavity trip rates. The results represent a significant improvement to the standard linac energy management tool and thereby could lead to a more efficient Continuous Electron Beam Accelerator Facility configuration. This study also serves as a proof of principle of how a genetic algorithm can be used for optimizing other linac-based machines.

  17. Observation of Self-Amplified Spontaneous Emission and Exponential Growth at 530 nm

    NASA Astrophysics Data System (ADS)

    Milton, S. V.; Gluskin, E.; Biedron, S. G.; Dejus, R. J.; den Hartog, P. K.; Galayda, J. N.; Kim, K.-J.; Lewellen, J. W.; Moog, E. R.; Sajaev, V.; Sereno, N. S.; Travish, G.; Vinokurov, N. A.; Arnold, N. D.; Benson, C.; Berg, W.; Biggs, J. A.; Borland, M.; Carwardine, J. A.; Chae, Y.-C.; Decker, G.; Deriy, B. N.; Erdmann, M. J.; Friedsam, H.; Gold, C.; Grelick, A. E.; Hahne, M. W.; Harkay, K. C.; Huang, Z.; Lessner, E. S.; Lill, R. M.; Lumpkin, A. H.; Makarov, O. A.; Markovich, G. M.; Meyer, D.; Nassiri, A.; Noonan, J. R.; Pasky, S. J.; Pile, G.; Smith, T. L.; Soliday, R.; Tieman, B. J.; Trakhtenberg, E. M.; Trento, G. F.; Vasserman, I. B.; Walters, D. R.; Wang, X. J.; Wiemerslage, G.; Xu, S.; Yang, B.-X.

    2000-07-01

    Experimental evidence for self-amplified spontaneous emission (SASE) at 530 nm is reported. The measurements were made at the low-energy undulator test line facility at the Advanced Photon Source, Argonne National Laboratory. The experimental setup and details of the experimental results are presented, as well as preliminary analysis. This experiment extends to shorter wavelengths the operational knowledge of a linac-based SASE free-electron laser and explicitly shows the predicted exponential growth in intensity of the optical pulse as a function of length along the undulator.

  18. Considerations on Beam Quality Control in MIT X-Ray FEL

    SciTech Connect

    Wang, D.; Graves, W.; Wang, D.; Zwart, T.; Emma, P.; Wu, J.; Huang, G.; /LBL, Berkeley

    2006-03-15

    The x-ray FEL at MIT is one example of a design for a new generation linac-based light source. Such a new machine requires very high quality electron beams. Besides the usual requirements on beam parameters such as emittance, energy spread, peak current, there are new challenges emerging in the design studies, e.g., the arrival timing of electron beam must reach precision below tens of femtoseconds level to ensure the laser seed overlaps the desired sections of electron bunch in the multiple-stage HGHG process. In this paper we report the progress on design optimization towards high quality and low sensitivity beams.

  19. A Parameter Optimization for a National SASE FEL Facility

    SciTech Connect

    Yavas, O.; Yigit, S.

    2007-04-23

    The parameter optimization for a national SASE FEL facility was studied. Turkish State Planing Organization (DPT) gave financial support as an inter-universities project to begin technical design studies and test facility of National Accelerator Complex starting from 2006. In addition to a particle factory, the complex will contain a linac based free electron laser, positron ring based synchrotron radiation facilities and a proton accelerator. In this paper, we have given some results of main parameters of SASE FEL facility based on 130 MeV linac, application potential in basic and applied research.

  20. High-Intensity Continuous Wave Slow Positron Source at Jefferson Lab

    NASA Astrophysics Data System (ADS)

    Golge, Serkan; Vlahovic, Branislav; Wojtsekhowski, Bogdan

    2013-04-01

    We present a novel concept of an electron linac-based slow positron source with projected intensity on the order of 10^10 slow e^+/s. The key components of this concept are a Continuous Wave (CW) electron beam, a rotating positron-production target, a synchronized raster/anti-raster, a transport channel, and extraction of positrons into a field-free area through a magnetic field terminator plug for moderation in a solid Neon moderator. The feasibility calculations were completed in the framework of GEANT4 simulation and OPERA-3D magnetic field calculation code.

  1. A review on photoneutrons characteristics in radiation therapy with high-energy photon beams

    PubMed Central

    Naseri, Alireza; Mesbahi, Asghar

    2010-01-01

    In radiation therapy with high-energy photon beams (E > 10 MeV) neutrons are generated mainly in linacs head thorough (γ,n) interactions of photons with nuclei of high atomic number materials that constitute the linac head and the beam collimation system. These neutrons affect the shielding requirements in radiation therapy rooms and also increase the out-of-field radiation dose of patients undergoing radiation therapy with high-energy photon beams. In the current review, the authors describe the factors influencing the neutron production for different medical linacs based on the performed measurements and Monte Carlo studies in the literature. PMID:24376940

  2. The 4th generation light source at Jefferson Lab

    NASA Astrophysics Data System (ADS)

    Benson, S.; Biallas, G.; Boyce, J.; Bullard, D.; Coleman, J.; Douglas, D.; Dylla, F.; Evans, R.; Evtushenko, P.; Grippo, A.; Gould, C.; Gubeli, J.; Hardy, D.; Hernandez-Garcia, C.; Jordan, K.; Klopf, J. M.; Moore, W.; Neil, G.; Powers, T.; Preble, J.; Sexton, D.; Shinn, M.; Tennant, C.; Walker, R.; Zhang, S.; Williams, G. P.

    2007-11-01

    A number of "Grand Challenges" in Science have recently been identified in reports from The National Academy of Sciences, and the US Department of Energy, Basic Energy Sciences. Many of these require a new generation of linac-based light source to study dynamical and non-linear phenomena in nanoscale samples. In this paper we present a summary of the properties of such light sources, comparing them with existing sources, and then describing in more detail a specific source at Jefferson Lab (JLab). Importantly, the JLab light source has developed some novel technology which is a critical enabler for other new light sources.

  3. A design study on high power RF system for the TARLA facility of TAC

    NASA Astrophysics Data System (ADS)

    Karslı, Özlem; Yavaş, Ömer

    2012-11-01

    The Turkish Accelerator and Radiation Laboratory in Ankara (TARLA) is a superconducting electron linac based IR FEL and Bremsstrahlung facility and it is under construction in Ankara as the first facility of the Turkish Accelerator Center (TAC) Project. TARLA will compose of two optical cavity systems to produce oscillator FEL in infrared region (2-250 μm) and also Bremsstrahlung radiation to be used in basic and applied sciences. In this study, main parameters of TARLA's high power RF and power transmission line systems are defined and a 20 kW RF solid state power amplifier is optimized.

  4. An MCNP-based model for the evaluation of the photoneutron dose in high energy medical electron accelerators.

    PubMed

    Carinou, Eleutheria; Stamatelatos, Ion Evangelos; Kamenopoulou, Vassiliki; Georgolopoulou, Paraskevi; Sandilos, Panayotis

    The development of a computational model for the treatment head of a medical electron accelerator (Elekta/Philips SL-18) by the Monte Carlo code mcnp-4C2 is discussed. The model includes the major components of the accelerator head and a pmma phantom representing the patient body. Calculations were performed for a 14 MeV electron beam impinging on the accelerator target and a 10 cmx10 cm beam area at the isocentre. The model was used in order to predict the neutron ambient dose equivalent at the isocentre level and moreover the neutron absorbed dose distribution within the phantom. Calculations were validated against experimental measurements performed by gold foil activation detectors. The results of this study indicated that the equivalent dose at tissues or organs adjacent to the treatment field due to photoneutrons could be up to 10% of the total peripheral dose, for the specific accelerator characteristics examined. Therefore, photoneutrons should be taken into account when accurate dose calculations are required to sensitive tissues that are adjacent to the therapeutic X-ray beam. The method described can be extended to other accelerators and collimation configurations as well, upon specification of treatment head component dimensions, composition and nominal accelerating potential. PMID:18348851

  5. The optimization of intensity modulated radiotherapy in cases where the planning target volume extends into the build-up region.

    PubMed

    Nguyen, T B; Hoole, A C F; Burnet, N G; Thomas, S J

    2009-04-21

    A common clinical problem in IMRT, especially when treating head and neck cases, is that the clinical target volume (CTV) stops short of the skin surface, whilst the margin for geometric uncertainties may take the planning target volume (PTV) to the skin surface or beyond. In these cases, optimization leads to over-dosing of the skin, unless the planner resorts to procedural tricks to avoid this, such as the use of pretend bolus or reduction of the PTV followed by adding 'flash' after optimization. This paper describes a method of avoiding the need for these tricks by using a multiple-isocentre CTV-based objective function. This enables plans to be produced that will give good coverage of the CTV for all the geometrical uncertainties that would have been covered by the PTV without causing the problem of over-dosing the skin. Eight isocentre shifts, equally distributed on the surface of a sphere with a radius equal to the CTV-PTV margin, are shown to be adequate for the optimization process. The resulting fluence maps are much simpler than those resulting from PTV optimization and will therefore be simpler to deliver. The method also permits better sparing of organs at risk such as the spinal cord. PMID:19336846

  6. Resampling: An optimization method for inverse planning in robotic radiosurgery

    SciTech Connect

    Schweikard, Achim; Schlaefer, Alexander; Adler, John R. Jr.

    2006-11-15

    By design, the range of beam directions in conventional radiosurgery are constrained to an isocentric array. However, the recent introduction of robotic radiosurgery dramatically increases the flexibility of targeting, and as a consequence, beams need be neither coplanar nor isocentric. Such a nonisocentric design permits a large number of distinct beam directions to be used in one single treatment. These major technical differences provide an opportunity to improve upon the well-established principles for treatment planning used with GammaKnife or LINAC radiosurgery. With this objective in mind, our group has developed over the past decade an inverse planning tool for robotic radiosurgery. This system first computes a set of beam directions, and then during an optimization step, weights each individual beam. Optimization begins with a feasibility query, the answer to which is derived through linear programming. This approach offers the advantage of completeness and avoids local optima. Final beam selection is based on heuristics. In this report we present and evaluate a new strategy for utilizing the advantages of linear programming to improve beam selection. Starting from an initial solution, a heuristically determined set of beams is added to the optimization problem, while beams with zero weight are removed. This process is repeated to sample a set of beams much larger compared with typical optimization. Experimental results indicate that the planning approach efficiently finds acceptable plans and that resampling can further improve its efficiency.

  7. A comprehensive EPID-based 3D validation technique for TrueBeam-delivered VMAT plans

    NASA Astrophysics Data System (ADS)

    Ansbacher, W.; Gagne, I. M.; Swift, C.-L.

    2014-03-01

    Purpose: To develop and validate a pre-treatment EPI dosimetry method on Varian TrueBeam linacs using continuous imaging, with reconstruction in a 3D cylindrical phantom geometry. Methods: Delivery of VMAT plans with continuous imaging is currently possible only in Research Mode on TrueBeam linacs, with images acquired in a proprietary format. An earlier technique was adapted to take advantage of technical improvements in EPID delivery, and was tested under various acquisition conditions. The dosimetry of VMAT plans was evaluated at isocentre and within patient volumes that had been transferred to the virtual phantom. Results: Approximately 60 portal image projections per arc were found to be adequate for 3D reconstruction in phantom volumes of 28cm diameter. Twelve prostate, CNS and Head & Neck deliveries were evaluated in Research mode relative to the corresponding Eclipse (v.10) treatment plans, and to measurements on an ArcCheck device in Treatment mode. Mean dose differences at isocentre were within 2% for the three-way comparison, and in PTV volumes were within 1% (s.d. 1%). However, some discrepancies were observed in ArcCheck results that may be related to the small dimensions of certain VMAT apertures. Conclusions: EPI dosimetry with 3D dose reconstruction is an accurate, comprehensive and efficient pre-treatment validation technique for VMAT delivery. Although currently limited to a research mode on TrueBeam, it has the potential to be implemented for clinical use.

  8. Effects of bone- and air-tissue inhomogeneities on the dose distributions of the Leksell Gamma Knife® calculated with PENELOPE

    NASA Astrophysics Data System (ADS)

    Al-Dweri, Feras M. O.; Rojas, E. Leticia; Lallena, Antonio M.

    2005-12-01

    Monte Carlo simulation with PENELOPE (version 2003) is applied to calculate Leksell Gamma Knife® dose distributions for heterogeneous phantoms. The usual spherical water phantom is modified with a spherical bone shell simulating the skull and an air-filled cube simulating the frontal or maxillary sinuses. Different simulations of the 201 source configuration of the Gamma Knife have been carried out with a simplified model of the geometry of the source channel of the Gamma Knife recently tested for both single source and multisource configurations. The dose distributions determined for heterogeneous phantoms including the bone- and/or air-tissue interfaces show non-negligible differences with respect to those calculated for a homogeneous one, mainly when the Gamma Knife isocentre approaches the separation surfaces. Our findings confirm an important underdosage (~10%) nearby the air-tissue interface, in accordance with previous results obtained with the PENELOPE code with a procedure different from ours. On the other hand, the presence of the spherical shell simulating the skull produces a few per cent underdosage at the isocentre wherever it is situated.

  9. A Technique for Stereotactic Radiosurgery Treatment Planning with Helical Tomotherapy

    PubMed Central

    Soisson, Emilie T.; Hoban, Peter W.; Kammeyer, Thomas; Kapatoes, Jeffrey M.; Westerly, David C.; Basavatia, Amar; Tomé, Wolfgang A.

    2009-01-01

    Purpose The purpose of this study was to develop an efficient and effective planning technique for stereotactic radiosurgery using helical tomotherapy. Methods and Materials Planning CTs and contours of twenty patients, previously treated in our clinic for brain metastases with Linac-based radiosurgery using circular collimators, were used to develop a robust Tomotherapy planning technique. Plan calculation times as well as delivery times were recorded for all patients to allow for an efficiency evaluation. In addition, conformation and homogeneity indices were calculated as metrics to compare plan quality to that which is achieved with conventional radiosurgery delivery systems. Results A robust and efficient planning technique was identified to produce plans of radiosurgical quality using the TomoTherapy treatment planning system. Dose calculation did not exceed a few hours and resulting delivery times were less than an hour, which allows the process to fit into a single day radiosurgery workflow. Plan conformity compared favorably with published results for Gamma Knife radiosurgery. In addition, plan homogeneity was similar to Linac-based approaches. Conclusions The TomoTherapy planning software can be used to create plans of acceptable quality for stereotactic radiosurgery in a time that is appropriate for a radiosurgery workflow that requires that planning and delivery occur within one treatment day. PMID:20138501

  10. An Injector Test Facility for the LCLS

    SciTech Connect

    Colby, E.,; /SLAC

    2007-03-14

    SLAC is in the privileged position of being the site for the world's first 4th generation light source as well as having a premier accelerator research staff and facilities. Operation of the world's first x-ray free electron laser (FEL) facility will require innovations in electron injectors to provide electron beams of unprecedented quality. Upgrades to provide ever shorter wavelength x-ray beams of increasing intensity will require significant advances in the state-of-the-art. The BESAC 20-Year Facilities Roadmap identifies the electron gun as ''the critical enabling technology to advance linac-based light sources'' and recognizes that the sources for next-generation light sources are ''the highest-leveraged technology'', and that ''BES should strongly support and coordinate research and development in this unique and critical technology''.[1] This white paper presents an R&D plan and a description of a facility for developing the knowledge and technology required to successfully achieve these upgrades, and to coordinate efforts on short-pulse source development for linac-based light sources.

  11. A Technique for Stereotactic Radiosurgery Treatment Planning with Helical Tomotherapy

    SciTech Connect

    Soisson, Emilie T.; Hoban, Peter W.; Kammeyer, Thomas; Kapatoes, Jeffrey M.; Westerly, David C.; Basavatia, Amar; Tome, Wolfgang A.

    2011-04-01

    The purpose of this study was to develop an efficient and effective planning technique for stereotactic radiosurgery using helical tomotherapy. Planning CTs and contours of 20 patients, previously treated in our clinic for brain metastases with linac-based radiosurgery using circular collimators, were used to develop a robust TomoTherapy planning technique. Plan calculation times as well as delivery times were recorded for all patients to allow for an efficiency evaluation. In addition, conformation and homogeneity indices were calculated as metrics to compare plan quality with that which is achieved with conventional radiosurgery delivery systems. A robust and efficient planning technique was identified to produce plans of radiosurgical quality using the TomoTherapy treatment planning system. Dose calculation did not exceed a few hours and resulting delivery times were less than 1 hour, which allows the process to fit into a single day radiosurgery workflow. Plan conformity compared favorably with published results for gamma knife radiosurgery. In addition, plan homogeneity was similar to linac-based approaches. The TomoTherapy planning software can be used to create plans of acceptable quality for stereotactic radiosurgery in a time that is appropriate for a radiosurgery workflow that requires that planning and delivery occur within 1 treatment day.

  12. Optimized Effective Potential for Quantum Electrodynamical Time-Dependent Density Functional Theory.

    PubMed

    Pellegrini, Camilla; Flick, Johannes; Tokatly, Ilya V; Appel, Heiko; Rubio, Angel

    2015-08-28

    We propose an orbital exchange-correlation functional for applying time-dependent density functional theory to many-electron systems coupled to cavity photons. The time nonlocal equation for the electron-photon optimized effective potential (OEP) is derived. In the static limit our OEP energy functional reduces to the Lamb shift of the ground state energy. We test the new approximation in the Rabi model. It is shown that the OEP (i) reproduces quantitatively the exact ground-state energy from the weak to the deep strong coupling regime and (ii) accurately captures the dynamics entering the ultrastrong coupling regime. The present formalism opens the path to a first-principles description of correlated electron-photon systems, bridging the gap between electronic structure methods and quantum optics for real material applications. PMID:26371646

  13. Strongly enhanced effects of Lorentz symmetry violation in entangled Yb+ ions

    NASA Astrophysics Data System (ADS)

    Dzuba, V. A.; Flambaum, V. V.; Safronova, M. S.; Porsev, S. G.; Pruttivarasin, T.; Hohensee, M. A.; Häffner, H.

    2016-05-01

    A number of theories aiming at unifying gravity with other fundamental interactions, including field theory, suggest the violation of Lorentz symmetry. Whereas the energy scale of such strongly Lorentz-symmetry-violating physics is much higher than that attainable at present by particle accelerators, Lorentz violation may nevertheless be detectable via precision measurements at low energies. Here, we carry out a systematic theoretical investigation to identify which atom shows the greatest promise for detecting a Lorentz symmetry violation in the electron-photon sector. We found that the ytterbium ion (Yb+) is an ideal system with high sensitivity, as well as excellent experimental controllability. By applying quantum-information-inspired technology to Yb+, we expect tests of local Lorentz invariance (LLI) violating physics in the electron-photon sector to reach levels of 10-23--five orders of magnitude more sensitive than the current best bounds.

  14. CEPXS

    SciTech Connect

    2015-10-19

    CEPXS is a multigroup-Legendre cross-section generating code. The cross sections produced by CEPXS enable coupled electron-photon transport calculations to be performed with multigroup radiation transport codes, e.g. MITS and SCEPTRE. CEPXS generates multigroup-Legendre cross sections for photons, electrons and positrons over the energy range from 100 MeV to 1.0 keV. The continuous slowing-down approximation is used for those electron interactions that result in small-energy losses. The extended transport correction is applied to the forward-peaked elastic scattering cross section for electrons. A standard multigroup-Legendre treatment is used for the other coupled electron-photon cross sections. CEPXS extracts electron cross-section information from the DATAPAC data set and photon cross-section information from Biggs-Lighthill data. The model that is used for ionization/relaxation in CEPXS is essentially the same as that employed in ITS.

  15. Data quality management system (DQMS) for BAC detector in the ZEUS experiment at the HERA accelerator

    NASA Astrophysics Data System (ADS)

    Luszczak, Zbigniew; Jezynski, Tomasz; Romaniuk, Ryszard S.; Pozniak, Krzysztof T.; Kuthan, Marcin; Bigos, Grzegorz; Gierej, Artur

    2003-10-01

    The paper presents functional structure of database system of data measurement quality for BAC detector in ZEUS experiment. The system collects diagnostic and experimental data. Diagnostic data are: work parameters of the detector and electronics/photonics, tests of electronic/photonic blocks. These data are archived for certain period of time. The quality of current data collection process is estimated using these archived data. The result of such estimation is generated in a form of status map of the detector. Such maps, describing status of the hardware, are fundamental for elementary particle analysis by the calorimeter. The DAQ system, collecting data to the database, estimates data quality on-line during transmission and writing. This mechanism of fast on-line data quality management leads to early discoveries of detector work irregularities and faults.

  16. Coincidence measurements of electron-impact coherence parameters for e-He scattering in the full range of scattering angles

    SciTech Connect

    Klosowski, Lukasz; Piwinski, Mariusz; Dziczek, Dariusz; Pleskacz, Katarzyna; Chwirot, Stanislaw

    2009-12-15

    Electron impact coherence parameters for inelastic e-He scattering have been measured for the excitation to the 2 {sup 1}P{sub 1} state at collision energy of 100 eV. The experiment was conducted using angular correlation electron-photon coincidence technique with a magnetic angle changer allowing measurements in full range of scattering angles. The results are compared with other experimental data and theoretical predictions available for this collisional system.

  17. Interpretation of the radioactive background observed in the OSO-7 gamma-ray monitor

    NASA Technical Reports Server (NTRS)

    Dyer, C. S.; Dunphy, P.; Forest, D. J.; Chupp, E. L.

    1975-01-01

    Application of a spallation activation calculation to the OSO-7 gamma-ray monitor background shows that major line features and about 30% of the continuum can be understood as activation of the central detector crystal by trapped protons. Weaker line features arise from activation of materials unshielded by the anticoincidence cup, while the remaining continuum and annihilation line would seem to come largely from electron-photon cascades originating in the spacecraft.

  18. Study of photonuclear muon interactions at Baksan underground scintillation telescope

    NASA Technical Reports Server (NTRS)

    Bakatanov, V. N.; Chudakov, A. E.; Dadykin, V. L.; Novoseltsev, Y. F.; Achkasov, V. M.; Semenov, A. M.; Stenkin, Y. V.

    1985-01-01

    The method of pion-muon-electron decays recording was used to distinguish between purely electron-photon and hadronic cascades, induced by high energy muons underground. At energy approx. 1 Tev a ratio of the number of hadronic to electromagnetic cascades was found equal 0.11 + or - .03 in agreement with expectation. But, at an energy approx. 4 Tev a sharp increase of this ratio was indicated though not statistically sound (0.52 + or - .13).

  19. Functionalization of metallic glasses through hierarchical patterning.

    PubMed

    Hasan, Molla; Schroers, Jan; Kumar, Golden

    2015-02-11

    Surface engineering over multiple length scales is critical for electronics, photonics, and enabling multifunctionality in synthetic materials. Here, we demonstrate a sequential embossing technique for building multi-tier patterns in metals by controlling the size-dependent thermoplastic forming of metallic glasses. Sub-100 nm to millimeter sized features are sculpted sequentially to allow an exquisite control of surface properties. The process can be integrated with net-shaping to transfer functional patterns on three-dimensional metal parts. PMID:25559737

  20. Lateral-angular and temporal characteristics of EAS optical radiation

    NASA Technical Reports Server (NTRS)

    Ivanenko, I. P.; Chuykova, T. A.; Galkin, V. I.; Roganova, T. M.

    1985-01-01

    Characteristics of the direct and scattered components of electron-photon shower optical radiation for distances R 500 m from the shower core to a detector, allowing for the Cerenkov and fluorescent mechanism of photon generation are presented. The results of calculations are employed to clarify the techniques for determination of the shower parameters detected by both installations registering fluorescent light and those recording Cerenkov light.

  1. Elastically Decoupling Dark Matter

    NASA Astrophysics Data System (ADS)

    Kuflik, Eric; Perelstein, Maxim; Lorier, Nicolas Rey-Le; Tsai, Yu-Dai

    2016-06-01

    We present a novel dark matter candidate, an elastically decoupling relic, which is a cold thermal relic whose present abundance is determined by the cross section of its elastic scattering on standard model particles. The dark matter candidate is predicted to have a mass ranging from a few to a few hundred MeV, and an elastic scattering cross section with electrons, photons and/or neutrinos in the 10-3- 1 fb range.

  2. Single-chip microprocessor that communicates directly using light

    NASA Astrophysics Data System (ADS)

    Sun, Chen; Wade, Mark T.; Lee, Yunsup; Orcutt, Jason S.; Alloatti, Luca; Georgas, Michael S.; Waterman, Andrew S.; Shainline, Jeffrey M.; Avizienis, Rimas R.; Lin, Sen; Moss, Benjamin R.; Kumar, Rajesh; Pavanello, Fabio; Atabaki, Amir H.; Cook, Henry M.; Ou, Albert J.; Leu, Jonathan C.; Chen, Yu-Hsin; Asanović, Krste; Ram, Rajeev J.; Popović, Miloš A.; Stojanović, Vladimir M.

    2015-12-01

    Data transport across short electrical wires is limited by both bandwidth and power density, which creates a performance bottleneck for semiconductor microchips in modern computer systems—from mobile phones to large-scale data centres. These limitations can be overcome by using optical communications based on chip-scale electronic-photonic systems enabled by silicon-based nanophotonic devices8. However, combining electronics and photonics on the same chip has proved challenging, owing to microchip manufacturing conflicts between electronics and photonics. Consequently, current electronic-photonic chips are limited to niche manufacturing processes and include only a few optical devices alongside simple circuits. Here we report an electronic-photonic system on a single chip integrating over 70 million transistors and 850 photonic components that work together to provide logic, memory, and interconnect functions. This system is a realization of a microprocessor that uses on-chip photonic devices to directly communicate with other chips using light. To integrate electronics and photonics at the scale of a microprocessor chip, we adopt a ‘zero-change’ approach to the integration of photonics. Instead of developing a custom process to enable the fabrication of photonics, which would complicate or eliminate the possibility of integration with state-of-the-art transistors at large scale and at high yield, we design optical devices using a standard microelectronics foundry process that is used for modern microprocessors. This demonstration could represent the beginning of an era of chip-scale electronic-photonic systems with the potential to transform computing system architectures, enabling more powerful computers, from network infrastructure to data centres and supercomputers.

  3. Automated Monte Carlo biasing for photon-generated electrons near surfaces.

    SciTech Connect

    Franke, Brian Claude; Crawford, Martin James; Kensek, Ronald Patrick

    2009-09-01

    This report describes efforts to automate the biasing of coupled electron-photon Monte Carlo particle transport calculations. The approach was based on weight-windows biasing. Weight-window settings were determined using adjoint-flux Monte Carlo calculations. A variety of algorithms were investigated for adaptivity of the Monte Carlo tallies. Tree data structures were used to investigate spatial partitioning. Functional-expansion tallies were used to investigate higher-order spatial representations.

  4. Modern developments in electron-beam fluorescence

    NASA Astrophysics Data System (ADS)

    Cattolica, Robert J.

    Recent developments in the area of electron-beam fluorescence are discussed with special attention given to the experience in the use of the electron-beam fluorescence in flight research. A new measurement approach, called electron-photon fluorescence (EPF), is described, and it is shown that EPF offers the potential of overcoming some of the disadvantages of electron-beam fluorescence in high-density flows. Examples of using the EPF technique are presented.

  5. Modern developments in electron-beam fluorescence

    NASA Technical Reports Server (NTRS)

    Cattolica, Robert J.

    1991-01-01

    Recent developments in the area of electron-beam fluorescence are discussed with special attention given to the experience in the use of the electron-beam fluorescence in flight research. A new measurement approach, called electron-photon fluorescence (EPF), is described, and it is shown that EPF offers the potential of overcoming some of the disadvantages of electron-beam fluorescence in high-density flows. Examples of using the EPF technique are presented.

  6. Proceeding of the 18th Intl. Workshop on Inelastic Ion-Surface Collisions (IISC-18)

    SciTech Connect

    Reinhold, Carlos O; Krstic, Predrag S; Meyer, Fred W

    2011-01-01

    The main topics of this proceedings were: (1) Energy loss of particles at surfaces; (2) Scattering of atoms, ions, molecules and clusters; (3) Charge exchange between particles and surfaces; (4) Ion induced desorption, electronic and kinetic sputtering; (5) Defect formation, surface modification and nanostructuring; (6) Electron, photon and secondary ion emission due to particle impact on surfaces; (7) Sputtering, fragmentation, cluster and ion formation in SIMS and SNMS; (8) Cluster/molecular and highly charged ion beams; and (9) Laser induced desorption.

  7. Elastically Decoupling Dark Matter.

    PubMed

    Kuflik, Eric; Perelstein, Maxim; Lorier, Nicolas Rey-Le; Tsai, Yu-Dai

    2016-06-01

    We present a novel dark matter candidate, an elastically decoupling relic, which is a cold thermal relic whose present abundance is determined by the cross section of its elastic scattering on standard model particles. The dark matter candidate is predicted to have a mass ranging from a few to a few hundred MeV, and an elastic scattering cross section with electrons, photons and/or neutrinos in the 10^{-3}-1  fb range. PMID:27314712

  8. Montecarlo simulation of photon induced air showers.

    NASA Astrophysics Data System (ADS)

    D'Ettorre Piazzoli, B.; di Sciascio, G.

    The EPAS code (Electron Photon induced Air Showers) is a three dimensional Montecarlo simulation developed to study the properties of extensive air showers generated by the interaction of high energy photons (or electrons) in the atmosphere. Results of the present simulation concern the longitudinal, lateral, temporal and angular distributions of electrons in atmospheric cascades initiated by photons of energies up to 100 TeV.

  9. Monte Carlo simulation of photon-induced air showers

    NASA Astrophysics Data System (ADS)

    D'Ettorre Piazzoli, B.; di Sciascio, G.

    1994-05-01

    The EPAS code (Electron Photon-induced Air Showers) is a three-dimensional Monte Carlo simulation developed to study the properties of extensive air showers (EAS) generated by the interaction of high energy photons (or electrons) in the atmosphere. Results of the present simulation concern the longitudinal, lateral, temporal and angular distributions of electrons in atmospheric cascades initiated by photons of energies up to 10^3 TeV.

  10. Photon drag effect in carbon nanotube yarns

    NASA Astrophysics Data System (ADS)

    Obraztsov, Alexander N.; Lyashenko, Dmitry A.; Fang, Shaoli; Baughman, Ray H.; Obraztsov, Petr A.; Garnov, Sergei V.; Svirko, Yuri P.

    2009-06-01

    We demonstrate that in graphitic nanocarbon materials, combination of ballistic conductivity and strong electron photon coupling opens a unique opportunity to observe transfer of momentum of the electromagnetic radiation to free carriers. The resulting drag of quasiballistically propagating electrons can be employed, in particular, to visualize the temporal profile, polarization, and propagation direction of the laser pulse. In this letter, we report the giant photon drag effect in yarns made of multiwall carbon nanotubes.

  11. Stabilizing Semiconductor Devices With Hydrogen

    NASA Technical Reports Server (NTRS)

    Overhauser, Albert W.; Maserjian, Joseph

    1989-01-01

    Damage by radiation healed rapidly. Feature provides continuous, rapid recovery of devices from degradation caused by hot electrons, photons, and ionizing radiation. Several candidate sites for palladium film catalysts, inserted during manufacture as integral parts of devices. Paladium films made by evaporation, sputtering, or chemical-vapor deposition. If additional storage required, thick layer of palladium plated on inside of package surrounding device. Hydrogen stored by exposing palladium to hydrogen gas just before package sealed hermetically.

  12. The electron structure and magnetic properties of TiCo intermetallic

    NASA Astrophysics Data System (ADS)

    Grechnev, G. E.; Svechkarev, I. V.

    1987-05-01

    The energy band structure and magnetic and some thermodynamic characteristics of TiCo are investigated theoretically in the low-temperature region. The nature of the stability of this intermetallic is determined. It is shown that TiCo is characterized by a strong exchange enhancement of spin susceptibility. The factors responsible for the strong paramagnetism and superconductivity of TiCo are identified; the parameters of electron-photon and electron-paramagnon interactions are determined.

  13. Single-chip microprocessor that communicates directly using light.

    PubMed

    Sun, Chen; Wade, Mark T; Lee, Yunsup; Orcutt, Jason S; Alloatti, Luca; Georgas, Michael S; Waterman, Andrew S; Shainline, Jeffrey M; Avizienis, Rimas R; Lin, Sen; Moss, Benjamin R; Kumar, Rajesh; Pavanello, Fabio; Atabaki, Amir H; Cook, Henry M; Ou, Albert J; Leu, Jonathan C; Chen, Yu-Hsin; Asanović, Krste; Ram, Rajeev J; Popović, Miloš A; Stojanović, Vladimir M

    2015-12-24

    Data transport across short electrical wires is limited by both bandwidth and power density, which creates a performance bottleneck for semiconductor microchips in modern computer systems--from mobile phones to large-scale data centres. These limitations can be overcome by using optical communications based on chip-scale electronic-photonic systems enabled by silicon-based nanophotonic devices. However, combining electronics and photonics on the same chip has proved challenging, owing to microchip manufacturing conflicts between electronics and photonics. Consequently, current electronic-photonic chips are limited to niche manufacturing processes and include only a few optical devices alongside simple circuits. Here we report an electronic-photonic system on a single chip integrating over 70 million transistors and 850 photonic components that work together to provide logic, memory, and interconnect functions. This system is a realization of a microprocessor that uses on-chip photonic devices to directly communicate with other chips using light. To integrate electronics and photonics at the scale of a microprocessor chip, we adopt a 'zero-change' approach to the integration of photonics. Instead of developing a custom process to enable the fabrication of photonics, which would complicate or eliminate the possibility of integration with state-of-the-art transistors at large scale and at high yield, we design optical devices using a standard microelectronics foundry process that is used for modern microprocessors. This demonstration could represent the beginning of an era of chip-scale electronic-photonic systems with the potential to transform computing system architectures, enabling more powerful computers, from network infrastructure to data centres and supercomputers. PMID:26701054

  14. Dynamic dosimetry and edema detection in prostate brachytherapy: a complete system

    NASA Astrophysics Data System (ADS)

    Jain, A.; Deguet, A.; Iordachita, I.; Chintalapani, G.; Blevins, J.; Le, Y.; Armour, E.; Burdette, C.; Song, D.; Fichtinger, G.

    2008-03-01

    Purpose: Brachytherapy (radioactive seed insertion) has emerged as one of the most effective treatment options for patients with prostate cancer, with the added benefit of a convenient outpatient procedure. The main limitation in contemporary brachytherapy is faulty seed placement, predominantly due to the presence of intra-operative edema (tissue expansion). Though currently not available, the capability to intra-operatively monitor the seed distribution, can make a significant improvement in cancer control. We present such a system here. Methods: Intra-operative measurement of edema in prostate brachytherapy requires localization of inserted radioactive seeds relative to the prostate. Seeds were reconstructed using a typical non-isocentric C-arm, and exported to a commercial brachytherapy delivery system. Technical obstacles for 3D reconstruction on a non-isocentric C-arm include pose-dependent C-arm calibration; distortion correction; pose estimation of C-arm images; seed reconstruction; and C-arm to TRUS registration. Results: In precision-machined hard phantoms with 40-100 seeds and soft tissue phantoms with 45-87 seeds, we correctly reconstructed the seed implant shape with an average 3D precision of 0.35 mm and 0.24 mm, respectively. In a DoD Phase-1 clinical trial on 6 patients with 48-82 planned seeds, we achieved intra-operative monitoring of seed distribution and dosimetry, correcting for dose inhomogeneities by inserting an average of 4.17 (1-9) additional seeds. Additionally, in each patient, the system automatically detected intra-operative seed migration induced due to edema (mean 3.84 mm, STD 2.13 mm, Max 16.19 mm). Conclusions: The proposed system is the first of a kind that makes intra-operative detection of edema (and subsequent re-optimization) possible on any typical non-isocentric C-arm, at negligible additional cost to the existing clinical installation. It achieves a significantly more homogeneous seed distribution, and has the potential to

  15. ELECTRON BEAM ION SOURCE PREINJECTOR PROJECT (EBIS) CONCEPTUAL DESIGN REPORT.

    SciTech Connect

    ALESSI, J.; BARTON, D.; BEEBE, E.; GASSNER, D.; GRANDINETTI, R.; HSEUH, H.; JAVIDFAR, A.; KPONOU, A.; LAMBIASE, R.; LESSARD, E.; LOCKEY, R.; LODESTRO, V.; MAPES, M.; MIRABELLA, D.; NEHRING, T.; OERTER, B.; PENDZICK, A.; PIKIN, A.; RAPARIA, D.; RITTER, J.; ROSER, T.; RUSSO, T.; SNYDSTRUP, L.; WILINSKI, M.; ZALTSMAN, A.; ZHANG, S.

    2005-09-01

    This report describes a new heavy ion pre-injector for the Relativistic Heavy Ion Collider (RHIC) based on a high charge state Electron Beam Ion Source (EBIS), a Radio Frequency Quadrupole (RFQ) accelerator, and a short Linear accelerator (Linac). The highly successful development of an EBIS at Brookhaven National Laboratory (BNL) now makes it possible to replace the present pre-injector that is based on an electrostatic Tandem with a reliable, low maintenance Linac-based pre-injector. Linac-based preinjectors are presently used at most accelerator and collider facilities with the exception of RHIC, where the required gold beam intensities could only be met with a Tandem until the recent EBIS development. EBIS produces high charge state ions directly, eliminating the need for the two stripping foils presently used with the Tandem. Unstable stripping efficiencies of these foils are a significant source of luminosity degradation in RHIC. The high reliability and flexibility of the new Linac-based pre-injector will lead to increased integrated luminosity at RHIC and is an essential component for the long-term success of the RHIC facility. This new pre-injector, based on an EBIS, also has the potential for significant future intensity increases and can produce heavy ion beams of all species including uranium beams and, as part of a future upgrade, might also be used to produce polarized {sup 3}He beams. These capabilities will be critical to the future luminosity upgrades and electron-ion collisions in RHIC. The proposed pre-injector system would also provide for a major enhancement in capability for the NASA Space Radiation Laboratory (NSRL), which utilizes heavy-ion beams from the RHIC complex. EBIS would allow for the acceleration of all important ion species for the NASA radiobiology program, such as, helium, argon, and neon which are unavailable with the present Tandem injector. In addition, the new system would allow for very rapid switching of ion species for

  16. A design of a rotating gantry for non-symmetric ion-therapy beams

    NASA Astrophysics Data System (ADS)

    Pavlovic, Márius

    1999-12-01

    An ion-optical design of a gantry for transport of ion beams having different emittances in the horizontal and vertical plane is presented. The ion-optical constraints making the beam spot at the gantry exit independent from the angle of gantry rotation are derived analytically. The generally formulated constraints are applied to an isocentric normal-conducting gantry transporting the beams with maximum beam rigidity of 6.6 Tm (e.g. 430 MeV/u carbon beam with a penetration range of 30 cm in water). The gantry is equipped with a two-direction magnetic raster scanning system. The ion-optical properties of the gantry are illustrated by computer simulations performed by the TRANSPORT code.

  17. Measurement of neutron ambient dose equivalent in carbon-ion radiotherapy with an active scanned delivery system.

    PubMed

    Yonai, S; Furukawa, T; Inaniwa, T

    2014-10-01

    In ion beam radiotherapy, secondary neutrons contribute to an undesired dose outside the target volume, and consequently the increase of secondary cancer risk is a growing concern. In this study, neutron ambient dose equivalents in carbon-ion radiotherapy (CIRT) with an active beam delivery system were measured with a rem meter, WENDI-II, at National Institute of Radiological Sciences. When the same irradiation target was assumed, the measured neutron dose with an active beam was at most ∼15 % of that with a passive beam. This percentage became smaller as larger distances from the iso-centre. Also, when using an active beam delivery system, the neutron dose per treatment dose in CIRT was comparable with that in proton radiotherapy. Finally, it was experimentally demonstrated that the use of an active scanned beam in CIRT can greatly reduce the secondary neutron dose. PMID:24126486

  18. Characterization of an add-on multileaf collimator for electron beam therapy

    NASA Astrophysics Data System (ADS)

    Gauer, T.; Sokoll, J.; Cremers, F.; Harmansa, R.; Luzzara, M.; Schmidt, R.

    2008-02-01

    An add-on multileaf collimator for electrons (eMLC) has been developed that provides computer-controlled beam collimation and isocentric dose delivery. The design parameters result from the design study by Gauer et al (2006 Phys. Med. Biol. 51 5987-6003) and were configured such that a compact and light-weight eMLC with motorized leaves can be industrially manufactured and stably mounted on a conventional linear accelerator. In the present study, the efficiency of an initial computer-controlled prototype was examined according to the design goals and the performance of energy- and intensity-modulated treatment techniques. This study concentrates on the attachment and gantry stability as well as the dosimetric characteristics of central-axis and off-axis dose, field size dependence, collimator scatter, field abutment, radiation leakage and the setting of the accelerator jaws. To provide isocentric irradiation, the eMLC can be placed either 16 or 28 cm above the isocentre through interchangeable holders. The mechanical implementation of this feature results in a maximum field displacement of less than 0.6 mm at 90° and 270° gantry angles. Compared to a 10 × 10 cm applicator at 6-14 MeV, the beam penumbra of the eMLC at a 16 cm collimator-to-isocentre distance is 0.8-0.4 cm greater and the depth-dose curves show a larger build-up effect. Due to the loss in energy dependence of the therapeutic range and the much lower dose output at small beam sizes, a minimum beam size of 3 × 3 cm is necessary to avoid suboptimal dose delivery. Dose output and beam symmetry are not affected by collimator scatter when the central axis is blocked. As a consequence of the broader beam penumbra, uniform dose distributions were measured in the junction region of adjacent beams at perpendicular and oblique beam incidence. However, adjacent beams with a high difference in a beam energy of 6 to 14 MeV generate cold and hot spots of approximately 15% in the abutting region. In order to

  19. Two new DOSXYZnrc sources for 4D Monte Carlo simulations of continuously variable beam configurations, with applications to RapidArc, VMAT, TomoTherapy and CyberKnife

    NASA Astrophysics Data System (ADS)

    Lobo, Julio; Antoniu Popescu, I.

    2010-08-01

    We present two new Monte Carlo sources for the DOSXYZnrc code, which can be used to compute dose distributions due to continuously variable beam configurations. These sources support a continuously rotating gantry and collimator, dynamic multileaf collimator (MLC) motion, variable monitor unit (MU) rate, couch rotation and translation in any direction, arbitrary isocentre motion with respect to the patient and variable source-to-axis distance (SAD). These features make them applicable to Monte Carlo simulations for RapidArc™, Elekta VMAT, TomoTherapy™ and CyberKnife™. Unique to these sources is the synchronization between the motion in the DOSXYZnrc geometry and the motion within the linac head, represented by a shared library (either a BEAMnrc accelerator with dynamic component modules, or an external library). The simulations are achieved in single runs, with no intermediate phase space files.

  20. Integrated megavoltage portal imaging with a 1.5 T MRI linac

    NASA Astrophysics Data System (ADS)

    Raaymakers, B. W.; de Boer, J. C. J.; Knox, C.; Crijns, S. P. M.; Smit, K.; Stam, M. K.; van den Bosch, M. R.; Kok, J. G. M.; Lagendijk, J. J. W.

    2011-10-01

    In this note, the feasibility of complementing our hybrid 1.5 T MRI linac (MRL) with a megavoltage (MV) portal imager is investigated. A standard aSi MV detector panel is added to the system and both qualitative and quantitative performances are determined. Simultaneous MR imaging and transmission imaging can be performed without mutual interference. The MV image quality is compromised by beam transmission and longer isocentre distance; still, the field edges and bony anatomy can be detected at very low dose levels of 0.4 cGy. MV imaging integrated with the MRL provides an independent and well-established position verification tool, a field edge check and a calibration for alignment of the coordinate systems of the MRI and the accelerator. The portal imager can also be a valuable means for benchmarking MRI-guided position verification protocols on a patient-specific basis in the introductory phase.

  1. Evaluation of a photon and an electron beam of a 6-MV linear accelerator.

    PubMed

    Sharma, S C; Modur, P; Basavatia, R

    1988-01-01

    The first Mitsubishi medical linear accelerator in the United States was commissioned in April 1985. This unit EXL-8 (marketed by Mitsubishi International Corporation) produces 8-MeV electron beams in addition to 6-MV x rays. It is a 100-cm source-axis distance isocentric machine. Acceptance testing and performance evaluation of this accelerator were completed. Our measurements included beam characteristics and dosimetry parameters for both modalities. Central axis % depth dose (% DD), tissue-maximum ratio, field size output factors, wedge factors, etc., for this Linac 6-MV beam, are reported. Characteristics of the 8-MeV electron beam, namely % DD data, isodose curves, and cone ratios for various electron applicators are presented. PMID:3211045

  2. Investigation of a MOSFET dosimetry system for midpoint dose verification in prostate 3D CRT/IMRT.

    PubMed

    Wiese, T; Bezak, E; Nelligan, R

    2008-09-01

    The suitability of MOSFETs (Metal Oxide Semiconductor Field Effect Transistors) for use in in-vivo dosimetry for IMRT prostate treatment and patient setup errors has been investigated in this work. MOSFETs were placed on entrance and exit surfaces of a number of different phantoms (with varying complexities from homogeneous to anthropomorphic). Dose measurements were then used to calculate a midpoint dose, which was compared with an IC placed at the isocentre. The agreements found between the calculated (MOSFETs) and the measured midpoint dose (IC) was: 0.7% for a prostate treatment verification and 3.5% for an IMRT treatment. MOSFETs placed on entry and exit surfaces can detect patient setup offsets of 2 cm, but do not have the sensitivity to confidently detect offsets of 1 cm or smaller. PMID:18946975

  3. Initial application of digital tomosynthesis with on-board imaging in radiation oncology

    NASA Astrophysics Data System (ADS)

    Baydush, Alan H.; Godfrey, Devon J.; Oldham, Mark; Dobbins, James T., III

    2005-04-01

    We present preliminary investigations that examine the feasibility of incorporating digital tomosynthesis into radiation oncology practice with the use of kilovoltage on-board imagers (OBI). Modern radiation oncology linear accelerators now include hardware options for the addition of OBI for on-line patient setup verification. These systems include an x-ray tube and detector mounted directly on the accelerator gantry that rotate with the same isocenter. Applications include cone beam computed tomography (CBCT), fluoroscopy, and radiographs to examine daily patient positioning to determine if the patient is in the same location as the treatment plan. While CBCT provides the greatest anatomical detail, this approach is limited by long acquisition and reconstruction times and higher patient dose. We propose to examine the use of tomosynthesis reconstructed volumetric data from limited angle projection images for short imaging time and reduced patient dose. Initial data uses 61 projection images acquired over an isocentric arc of twenty degrees with the detector approximately fifty-four centimeters from isocenter. A modified filtered back projection technique, which included a mathematical correction for isocentric motion, was used to reconstruct volume images. These images will be visually and mathematically compared to volumetric computed tomography images to determine efficacy of this system for daily patient positioning verification. Initial images using the tomosynthesis reconstruction technique show much promise and bode well for effective daily patient positioning verification with reduced patient dose and imaging time. Additionally, the fast image acquisition may allow for a single breath hold imaging sequence, which will have no breath motion.

  4. A modular approach to intensity-modulated arc therapy optimization with noncoplanar trajectories.

    PubMed

    Papp, Dávid; Bortfeld, Thomas; Unkelbach, Jan

    2015-07-01

    Utilizing noncoplanar beam angles in volumetric modulated arc therapy (VMAT) has the potential to combine the benefits of arc therapy, such as short treatment times, with the benefits of noncoplanar intensity modulated radiotherapy (IMRT) plans, such as improved organ sparing. Recently, vendors introduced treatment machines that allow for simultaneous couch and gantry motion during beam delivery to make noncoplanar VMAT treatments possible. Our aim is to provide a reliable optimization method for noncoplanar isocentric arc therapy plan optimization. The proposed solution is modular in the sense that it can incorporate different existing beam angle selection and coplanar arc therapy optimization methods. Treatment planning is performed in three steps. First, a number of promising noncoplanar beam directions are selected using an iterative beam selection heuristic; these beams serve as anchor points of the arc therapy trajectory. In the second step, continuous gantry/couch angle trajectories are optimized using a simple combinatorial optimization model to define a beam trajectory that efficiently visits each of the anchor points. Treatment time is controlled by limiting the time the beam needs to trace the prescribed trajectory. In the third and final step, an optimal arc therapy plan is found along the prescribed beam trajectory. In principle any existing arc therapy optimization method could be incorporated into this step; for this work we use a sliding window VMAT algorithm. The approach is demonstrated using two particularly challenging cases. The first one is a lung SBRT patient whose planning goals could not be satisfied with fewer than nine noncoplanar IMRT fields when the patient was treated in the clinic. The second one is a brain tumor patient, where the target volume overlaps with the optic nerves and the chiasm and it is directly adjacent to the brainstem. Both cases illustrate that the large number of angles utilized by isocentric noncoplanar VMAT plans

  5. Clinical implementation and rapid commissioning of an EPID based in-vivo dosimetry system

    NASA Astrophysics Data System (ADS)

    Hanson, Ian M.; Hansen, Vibeke N.; Olaciregui-Ruiz, Igor; van Herk, Marcel

    2014-10-01

    Using an Electronic Portal Imaging Device (EPID) to perform in-vivo dosimetry is one of the most effective and efficient methods of verifying the safe delivery of complex radiotherapy treatments. Previous work has detailed the development of an EPID based in-vivo dosimetry system that was subsequently used to replace pre-treatment dose verification of IMRT and VMAT plans. Here we show that this system can be readily implemented on a commercial megavoltage imaging platform without modification to EPID hardware and without impacting standard imaging procedures. The accuracy and practicality of the EPID in-vivo dosimetry system was confirmed through a comparison with traditional TLD in-vivo measurements performed on five prostate patients. The commissioning time required for the EPID in-vivo dosimetry system was initially prohibitive at approximately 10 h per linac. Here we present a method of calculating linac specific EPID dosimetry correction factors that allow a single energy specific commissioning model to be applied to EPID data from multiple linacs. Using this method reduced the required per linac commissioning time to approximately 30 min. The validity of this commissioning method has been tested by analysing in-vivo dosimetry results of 1220 patients acquired on seven linacs over a period of 5 years. The average deviation between EPID based isocentre dose and expected isocentre dose for these patients was (-0.7  ±  3.2)%. EPID based in-vivo dosimetry is now the primary in-vivo dosimetry tool used at our centre and has replaced nearly all pre-treatment dose verification of IMRT treatments.

  6. The relative biological effectiveness of out-of-field dose

    NASA Astrophysics Data System (ADS)

    Balderson, Michael; Koger, Brandon; Kirkby, Charles

    2016-01-01

    Purpose: using simulations and models derived from existing literature, this work investigates relative biological effectiveness (RBE) for out-of-field radiation and attempts to quantify the relative magnitudes of different contributing phenomena (spectral, bystander, and low dose hypersensitivity effects). Specific attention is paid to external beam radiotherapy treatments for prostate cancer. Materials and methods: using different biological models that account for spectral, bystander, and low dose hypersensitivity effects, the RBE was calculated for different points moving radially out from isocentre for a typical single arc VMAT prostate case. The RBE was found by taking the ratio of the equivalent dose with the physical dose. Equivalent doses were calculated by determining what physical dose would be necessary to produce the same overall biological effect as that predicted using the different biological models. Results: spectral effects changed the RBE out-of-field less than 2%, whereas response models incorporating low dose hypersensitivity and bystander effects resulted in a much more profound change of the RBE for out-of-field doses. The bystander effect had the largest RBE for points located just outside the edge of the primary radiation beam in the cranial caudal (z-direction) compared to low dose hypersensitivity and spectral effects. In the coplanar direction, bystander effect played the largest role in enhancing the RBE for points up to 8.75 cm from isocentre. Conclusions: spectral, bystander, and low dose hypersensitivity effects can all increase the RBE for out-of-field radiation doses. In most cases, bystander effects seem to play the largest role followed by low dose hypersensitivity. Spectral effects were unlikely to be of any clinical significance. Bystander, low dose hypersensitivity, and spectral effect increased the RBE much more in the cranial caudal direction (z-direction) compared with the coplanar directions.

  7. SU-E-T-432: A Rapid and Comprehensive Procedure for Daily Proton QA

    SciTech Connect

    Zhao, T; Sun, B; Grantham, K; Knutson, N; Santanam, L; Goddu, S; Klein, E

    2014-06-01

    Purpose: The objective is to develop a rapid and comprehensive daily QA procedure implemented at the S. Lee Kling Proton Therapy Center at Barnes-Jewish Hospital. Methods: A scribed phantom with imbedded fiducials is used for checking lasers accuracy followed by couch isocentricity and for X-ray imaging congruence with isocenter. A Daily QA3 device (Sun Nuclear, FL) was used to check output, range and profiles. Five chambers in the central region possess various build-ups. After converting the thickness of the inherent build-ups into water equivalent thickness (WET) for proton, range of any beam can be checked with additional build-up on the Daily QA3 device. In our procedure, 3 beams from 3 bands (large, small and deep) with nominal range of 20 cm are checked daily. 17cm plastic water with WET of 16.92cm are used as additional build-up so that four chambers sit on the SOBP plateau at various depths and one sit on the distal fall off. Reading from the five chambers are fitted to an error function that has been parameterized to match the SOBP with the same nominal range. Shifting of the error function to maximize the correlation between measurements and the error function is deemed as the range shift from the nominal value. Results: We have found couch isocentricity maintained over 180 degrees. Imaging system exhibits accuracy in regard to imaging and mechanical isocenters. Ranges are within 1mm accuracy from measurements in water tank, and sensitive to change of sub-millimeter. Data acquired since the start of operation show outputs, profiles and range stay within 1% or 1mm from baselines. The whole procedure takes about 40 minutes. Conclusion: Taking advantage of the design of Daily QA3 device turns the device originally designed for photon and electron into a comprehensive and rapid tool for proton daily QA.

  8. Peripheral photon and neutron doses from prostate cancer external beam irradiation.

    PubMed

    Bezak, Eva; Takam, Rundgham; Marcu, Loredana G

    2015-12-01

    Peripheral photon and neutron doses from external beam radiotherapy (EBRT) are associated with increased risk of carcinogenesis in the out-of-field organs; thus, dose estimations of secondary radiation are imperative. Peripheral photon and neutron doses from EBRT of prostate carcinoma were measured in Rando phantom. (6)LiF:Mg,Cu,P and (7)LiF:Mg,Cu,P glass-rod thermoluminescence dosemeters (TLDs) were inserted in slices of a Rando phantom followed by exposure to 80 Gy with 18-MV photon four-field 3D-CRT technique. The TLDs were calibrated using 6- and 18-MV X-ray beam. Neutron dose equivalents measured with CR-39 etch-track detectors were used to derive readout-to-neutron dose conversion factor for (6)LiF:Mg,Cu,P TLDs. Average neutron dose equivalents per 1 Gy of isocentre dose were 3.8±0.9 mSv Gy(-1) for thyroid and 7.0±5.4 mSv Gy(-1) for colon. For photons, the average dose equivalents per 1 Gy of isocentre dose were 0.2±0.1 mSv Gy(-1) for thyroid and 8.1±9.7 mSv Gy(-1) for colon. Paired (6)LiF:Mg,Cu,P and (7)LiF:Mg,Cu,P TLDs can be used to measure photon and neutron doses simultaneously. Organs in close proximity to target received larger doses from photons than those from neutrons whereas distally located organs received higher neutron versus photon dose. PMID:25564673

  9. Clinical implementation and rapid commissioning of an EPID based in-vivo dosimetry system.

    PubMed

    Hanson, Ian M; Hansen, Vibeke N; Olaciregui-Ruiz, Igor; van Herk, Marcel

    2014-10-01

    Using an Electronic Portal Imaging Device (EPID) to perform in-vivo dosimetry is one of the most effective and efficient methods of verifying the safe delivery of complex radiotherapy treatments. Previous work has detailed the development of an EPID based in-vivo dosimetry system that was subsequently used to replace pre-treatment dose verification of IMRT and VMAT plans. Here we show that this system can be readily implemented on a commercial megavoltage imaging platform without modification to EPID hardware and without impacting standard imaging procedures. The accuracy and practicality of the EPID in-vivo dosimetry system was confirmed through a comparison with traditional TLD in-vivo measurements performed on five prostate patients.The commissioning time required for the EPID in-vivo dosimetry system was initially prohibitive at approximately 10 h per linac. Here we present a method of calculating linac specific EPID dosimetry correction factors that allow a single energy specific commissioning model to be applied to EPID data from multiple linacs. Using this method reduced the required per linac commissioning time to approximately 30 min.The validity of this commissioning method has been tested by analysing in-vivo dosimetry results of 1220 patients acquired on seven linacs over a period of 5 years. The average deviation between EPID based isocentre dose and expected isocentre dose for these patients was (-0.7  ±  3.2)%.EPID based in-vivo dosimetry is now the primary in-vivo dosimetry tool used at our centre and has replaced nearly all pre-treatment dose verification of IMRT treatments. PMID:25211121

  10. SU-E-T-632: A Dosimetric Comparison of the 3D-CRT Planning of Chest Wall in Post-Mastectomy Breast Cancer Patients, with and Without Breast Board Setup

    SciTech Connect

    Muzaffar, Ambreen; Masood, Asif; Ullah, Haseeb; Mehmood, Kashif; Qasim, Uzma; Afridi, M. Ali; Khan, Salim; Hameed, Abdul

    2014-06-15

    Purpose: Breast boards are used in breast radiation which increases normal lung and heart doses, when supraclavicular field is included. Therefore, in this study through dose volume histogram (DVHs), lung and heart doses comparison was done between two different setups i.e. with and without breast board, for the treatment of left chest wall and supraclavicular fossa in postmastectomy left breast cancer. Methods: In this study, CT-Simulation scans of ten breast cancer patients were done with and without breast board, at Shifa International Hospitals Islamabad, to investigate the differences between the two different setups of the irradiation of left chest wall in terms of lung and heart doses. For immobilization, support under the neck, shoulders and arms was used. Precise PLAN 2.15 treatment planning system (TPS) was used for 3D-CRT planning. The total prescribed dose for both the plans was 5000 cGy/25 fractions. The chest wall was treated with a pair of tangential photon fields and the upper supraclavicular nodal regions were treated with an anterior photon field. A mono-isocentric technique was used to match the tangential fields with the anterior field at the isocentre. The dose volume histogram was used to compare the doses of heart and ipsilateral lung. Results: Both the plans of each patient were generated and compared. DVH results showed that for the same PTV dose coverage, plans without breast board resulted in a reduction of lung and heart doses compared with the plans with breast board. There was significant reductions in V20, V<25 and mean doses for lung and V<9 and mean doses for heart. Conclusion: In comparison of both the plans, setup without breast board significantly reduced the dose-volume of the ipsilateral lung and heart in left chest wall patients. Waived registration request has been submitted.

  11. Quality assurance devices for dynamic conformal radiotherapy.

    PubMed

    Wong, Victy Y M

    2004-01-01

    Two quality control devices, light-field device and radiation-field device, have been specially designed to facilitate the clinical implementation of conformal dynamic arc treatment (CDAT) and intensity modulated radiation therapy (IMRT). With the devices, the light field as well as the radiation field, projected from the individual beam at any treatment position (i.e. arbitrary gantry angle) can be evaluated. For application, the device was attached at the front end of the couch and was placed at the isocentre of the linear accelerator treatment system (LINAC). The devices are designed to be rotated parallel to the gantry head so that the light field and the radiation field projected from a direct beam can be assessed. The aim of the study is, with the aid of the devices, to evaluate the geometric precision of the beam placement and the dosimetric accuracy performed in CDAT and IMRT. The devices are placed separately from the LINAC during application and provide an independent check on the quality performance of the LINAC in three dimensions. The condition of gantry sag and any mechanical displacement resulting in field shift can be observed and traced during gantry rotation. Mistakes that occurred during the isocentre calibration can lead to significant displacement in the field projection, which would not be revealed with the conventional quality control setting (i.e. gantry 0(o)), was demonstrated with the aid of the devices here. The influence of gravitational acceleration in MLC leaf positioning error, which would consequently lead to inaccurate dose delivery, was investigated. The results of our study show that the existence of gravitational influence is statistically significant, although the magnitude of the dose inaccuracy has been found to be small. PMID:15753929

  12. A modular approach to intensity-modulated arc therapy optimization with noncoplanar trajectories

    NASA Astrophysics Data System (ADS)

    Papp, Dávid; Bortfeld, Thomas; Unkelbach, Jan

    2015-07-01

    Utilizing noncoplanar beam angles in volumetric modulated arc therapy (VMAT) has the potential to combine the benefits of arc therapy, such as short treatment times, with the benefits of noncoplanar intensity modulated radiotherapy (IMRT) plans, such as improved organ sparing. Recently, vendors introduced treatment machines that allow for simultaneous couch and gantry motion during beam delivery to make noncoplanar VMAT treatments possible. Our aim is to provide a reliable optimization method for noncoplanar isocentric arc therapy plan optimization. The proposed solution is modular in the sense that it can incorporate different existing beam angle selection and coplanar arc therapy optimization methods. Treatment planning is performed in three steps. First, a number of promising noncoplanar beam directions are selected using an iterative beam selection heuristic; these beams serve as anchor points of the arc therapy trajectory. In the second step, continuous gantry/couch angle trajectories are optimized using a simple combinatorial optimization model to define a beam trajectory that efficiently visits each of the anchor points. Treatment time is controlled by limiting the time the beam needs to trace the prescribed trajectory. In the third and final step, an optimal arc therapy plan is found along the prescribed beam trajectory. In principle any existing arc therapy optimization method could be incorporated into this step; for this work we use a sliding window VMAT algorithm. The approach is demonstrated using two particularly challenging cases. The first one is a lung SBRT patient whose planning goals could not be satisfied with fewer than nine noncoplanar IMRT fields when the patient was treated in the clinic. The second one is a brain tumor patient, where the target volume overlaps with the optic nerves and the chiasm and it is directly adjacent to the brainstem. Both cases illustrate that the large number of angles utilized by isocentric noncoplanar VMAT plans

  13. DAVID—a translucent multi-wire transmission ionization chamber for in vivo verification of IMRT and conformal irradiation techniques

    NASA Astrophysics Data System (ADS)

    Poppe, B.; Thieke, C.; Beyer, D.; Kollhoff, R.; Djouguela, A.; Rühmann, A.; Willborn, K. C.; Harder, D.

    2006-03-01

    Permanent in vivo verification of IMRT photon beam profiles by a radiation detector with spatial resolution, positioned on the radiation entrance side of the patient, has not been clinically available so far. In this work we present the DAVID system, which is able to perform this quality assurance measurement while the patient is treated. The DAVID system is a flat, multi-wire transmission-type ionization chamber, placed in the accessory holder of the linear accelerator and constructed from translucent materials in order not to interfere with the light field. Each detection wire of the chamber is positioned exactly in the projection line of a MLC leaf pair, and the signal of each wire is proportional to the line integral of the ionization density along this wire. Thereby, each measurement channel essentially presents the line integral of the ionization density over the opening width of the associated leaf pair. The sum of all wire signals is a measure of the dose-area product of the transmitted photon beam and of the total radiant energy administered to the patient. After the dosimetric verification of an IMRT plan, the values measured by the DAVID system are stored as reference values. During daily treatment the signals are re-measured and compared to the reference values. A warning is output if there is a deviation beyond a threshold. The error detection capability is a leaf position error of less than 1 mm for an isocentric 1 cm × 1 cm field, and of 1 mm for an isocentric 20 cm × 20 cm field.

  14. Experimental characterization of two-dimensional spot profiles for two proton pencil beam scanning nozzles

    NASA Astrophysics Data System (ADS)

    Lin, Liyong; Ainsley, Christopher G.; Solberg, Timothy D.; McDonough, James E.

    2014-01-01

    Dose calculation for pencil beam scanning proton therapy requires accurate measurement of the broad tails of the proton spot profiles for every nozzle in clinical use. By applying a pair/magnification method and merging film data, 200 mm × 240 mm dose kernels extending to 10-4 of the central spot dose are generated for six selected energies of the IBA dedicated and universal nozzles (DN and UN). One-dimensional, circular profiles up to 100 mm in radius are generated from the asymmetric profiles to facilitate spot profile comparison. For the highest energy, 225 MeV, the output of both the DN and the UN for field sizes from 40 to 200 mm increases in parallel, slowest at the surface (˜1%) and fastest at a depth of 150 mm (˜9%). In contrast, at the lowest energy, 100 MeV, the output of the DN across the same range of field sizes increases 3-4% versus 6-7% for the UN throughout all the depths. The charge deficits in the measured depth-dose of Bragg peaks are similar between the UN and the DN. At 100 MeV, the field size factor difference at the surface between two orientations of a rectangular 40 mm × 200 mm field is 1.4% at isocentre for the DN versus 2% for the UN. Though the one-dimensional distributions are similar for the primary and tail components at different positions, the primary components of the DN spots are more elliptical 270 mm upstream than at isocentre.

  15. Pencil beam scanning dosimetry for large animal irradiation.

    PubMed

    Lin, Liyong; Solberg, Timothy D; Carabe, Alexandro; Mcdonough, James E; Diffenderfer, Eric; Sanzari, Jenine K; Kennedy, Ann R; Cengel, Keith

    2014-09-01

    The space radiation environment imposes increased dangers of exposure to ionizing radiation, particularly during a solar particle event. These events consist primarily of low-energy protons that produce a highly inhomogeneous depth-dose distribution. Here we describe a novel technique that uses pencil beam scanning at extended source-to-surface distances and range shifter (RS) to provide robust but easily modifiable delivery of simulated solar particle event radiation to large animals. Thorough characterization of spot profiles as a function of energy, distance and RS position is critical to accurate treatment planning. At 105 MeV, the spot sigma is 234 mm at 4800 mm from the isocentre when the RS is installed at the nozzle. With the energy increased to 220 MeV, the spot sigma is 66 mm. At a distance of 1200 mm from the isocentre, the Gaussian sigma is 68 mm and 23 mm at 105 MeV and 220 MeV, respectively, when the RS is located on the nozzle. At lower energies, the spot sigma exhibits large differences as a function of distance and RS position. Scan areas of 1400 mm (superior-inferior) by 940 mm (anterior-posterior) and 580 mm by 320 mm are achieved at the extended distances of 4800 mm and 1200 mm, respectively, with dose inhomogeneity <2%. To treat large animals with a more sophisticated dose distribution, spot size can be reduced by placing the RS closer than 70 mm to the surface of the animals, producing spot sigmas below 6 mm. PMID:24855043

  16. Experimental characterization of two-dimensional spot profiles for two proton pencil beam scanning nozzles.

    PubMed

    Lin, Liyong; Ainsley, Christopher G; Solberg, Timothy D; McDonough, James E

    2014-01-20

    Dose calculation for pencil beam scanning proton therapy requires accurate measurement of the broad tails of the proton spot profiles for every nozzle in clinical use. By applying a pair/magnification method and merging film data, 200 mm × 240 mm dose kernels extending to 10(-4) of the central spot dose are generated for six selected energies of the IBA dedicated and universal nozzles (DN and UN). One-dimensional, circular profiles up to 100 mm in radius are generated from the asymmetric profiles to facilitate spot profile comparison. For the highest energy, 225 MeV, the output of both the DN and the UN for field sizes from 40 to 200 mm increases in parallel, slowest at the surface (∼1%) and fastest at a depth of 150 mm (∼9%). In contrast, at the lowest energy, 100 MeV, the output of the DN across the same range of field sizes increases 3-4% versus 6-7% for the UN throughout all the depths. The charge deficits in the measured depth-dose of Bragg peaks are similar between the UN and the DN. At 100 MeV, the field size factor difference at the surface between two orientations of a rectangular 40 mm × 200 mm field is 1.4% at isocentre for the DN versus 2% for the UN. Though the one-dimensional distributions are similar for the primary and tail components at different positions, the primary components of the DN spots are more elliptical 270 mm upstream than at isocentre. PMID:24374943

  17. Pencil beam scanning dosimetry for large animal irradiation

    PubMed Central

    Lin, Liyong; Solberg, Timothy D.; Carabe, Alexandro; Mcdonough, James E.; Diffenderfer, Eric; Sanzari, Jenine K.; Kennedy, Ann R.; Cengel, Keith

    2014-01-01

    The space radiation environment imposes increased dangers of exposure to ionizing radiation, particularly during a solar particle event. These events consist primarily of low-energy protons that produce a highly inhomogeneous depth–dose distribution. Here we describe a novel technique that uses pencil beam scanning at extended source-to-surface distances and range shifter (RS) to provide robust but easily modifiable delivery of simulated solar particle event radiation to large animals. Thorough characterization of spot profiles as a function of energy, distance and RS position is critical to accurate treatment planning. At 105 MeV, the spot sigma is 234 mm at 4800 mm from the isocentre when the RS is installed at the nozzle. With the energy increased to 220 MeV, the spot sigma is 66 mm. At a distance of 1200 mm from the isocentre, the Gaussian sigma is 68 mm and 23 mm at 105 MeV and 220 MeV, respectively, when the RS is located on the nozzle. At lower energies, the spot sigma exhibits large differences as a function of distance and RS position. Scan areas of 1400 mm (superior–inferior) by 940 mm (anterior–posterior) and 580 mm by 320 mm are achieved at the extended distances of 4800 mm and 1200 mm, respectively, with dose inhomogeneity <2%. To treat large animals with a more sophisticated dose distribution, spot size can be reduced by placing the RS closer than 70 mm to the surface of the animals, producing spot sigmas below 6 mm. PMID:24855043

  18. Angular dependence of mammographic dosimeters in digital breast tomosynthesis

    NASA Astrophysics Data System (ADS)

    Bradley, Lena R.; Carton, Ann-Katherine; Maidment, Andrew D. A.

    2010-04-01

    Digital Breast Tomosynthesis (DBT) is an emerging imaging modality that combines tomography with conventional digital mammography. In developing DBT dosimetry, a direct application of mammographic dosimetry has appeal. However, DBT introduces rotation of the x-ray tube relative to the dosimeter, thus raising questions about the angular dependence of mammographic dosimeters. To measure this dependence, two ionization chambers, two solid-stated detectors, and one photodiode were rotated relative to an incident Mo/Mo x-ray beam. In this isocentric DBT simulation, the signal of each dosimeter was studied over an angular range of 180° for tube voltages of 26 to 34 kV. One ionization chamber was then modeled numerically to study the response to various monoenergetic beams. The results show that all dosimeters underestimate dose to varying degrees; solid-state detectors show the greatest angular dependence while ionization chambers show the least. Correction factors were computed from the data for isocentric DBT images using projection angles up to +/-25° these factors ranged from 1.0014 to 1.1380. The magnitude of the angular dependence generally decreased with increasing energy, as shown with both the measured and modeled data. As a result, the error arising in measuring DBT dose with a mammographic dosimeter varies significantly; it cannot always be disregarded. The use of correction factors may be possible but is largely impractical, as they are specific to the dosimeter, x-ray beam, and DBT geometry. Instead, an angle-independent dosimeter may be more suitable for DBT.

  19. The role of the concept of biologically effective dose (BED) in treatment planning in radiosurgery.

    PubMed

    Millar, William T; Hopewell, John W; Paddick, Ian; Lindquist, Christer; Nordströn, Håkan; Lidberg, Pär; Gårding, Jonas

    2015-09-01

    Radiosurgery (RS) treatment times vary, even for the same prescription dose, due to variations in the collimator size, the number of iso-centres/beams/arcs used and the time gap between each of these exposures. The biologically effective dose (BED) concept, incorporating fast and slow components of repair, was used to show the likely influence of these variables for Gamma Knife patients with Vestibular Schwannomas. Two patients plans were selected, treated with the Model B Gamma Knife, these representing the widest range of treatment variables; iso-centre numbers 3 and 13, overall treatment times 25.4 and 129.6 min, prescription dose 14 Gy. These were compared with 3 cases treated with the Perfexion(®) Gamma Knife. The iso-centre number varied between 11 and 18, treatment time 35.7 - 74.4 min, prescription dose 13 Gy. In the longer Model B Gamma Knife treatment plan the 14 Gy iso-dose was best matched by the 58 Gy2.47 iso-BED line, although higher and lower BED values were associated with regions on the prescription iso-dose. The equivalent value for the shorter treatment was 85 Gy2.47. BED volume histograms showed that a BED of 85 Gy2.47 only covered ∼65% of the target in the plan with the longer overall treatment time. The corresponding BED values for the 3 cases, treated with the Perfexion(®) Gamma Knife, were 59.5, 68.5 and 71.5 Gy2.47. In conclusion BED calculations, taking account of the repair of sublethal damage, may indicate the importance of reporting overall time to reflect the biological effectiveness of the total physical dose applied. PMID:25982304

  20. DAVID--a translucent multi-wire transmission ionization chamber for in vivo verification of IMRT and conformal irradiation techniques.

    PubMed

    Poppe, B; Thieke, C; Beyer, D; Kollhoff, R; Djouguela, A; Rühmann, A; Willborn, K C; Harder, D

    2006-03-01

    Permanent in vivo verification of IMRT photon beam profiles by a radiation detector with spatial resolution, positioned on the radiation entrance side of the patient, has not been clinically available so far. In this work we present the DAVID system, which is able to perform this quality assurance measurement while the patient is treated. The DAVID system is a flat, multi-wire transmission-type ionization chamber, placed in the accessory holder of the linear accelerator and constructed from translucent materials in order not to interfere with the light field. Each detection wire of the chamber is positioned exactly in the projection line of a MLC leaf pair, and the signal of each wire is proportional to the line integral of the ionization density along this wire. Thereby, each measurement channel essentially presents the line integral of the ionization density over the opening width of the associated leaf pair. The sum of all wire signals is a measure of the dose-area product of the transmitted photon beam and of the total radiant energy administered to the patient. After the dosimetric verification of an IMRT plan, the values measured by the DAVID system are stored as reference values. During daily treatment the signals are re-measured and compared to the reference values. A warning is output if there is a deviation beyond a threshold. The error detection capability is a leaf position error of less than 1 mm for an isocentric 1 cm x 1 cm field, and of 1 mm for an isocentric 20 cm x 20 cm field. PMID:16481690

  1. Liquid sample delivery techniques for serial femtosecond crystallography

    PubMed Central

    Weierstall, Uwe

    2014-01-01

    X-ray free-electron lasers overcome the problem of radiation damage in protein crystallography and allow structure determination from micro- and nanocrystals at room temperature. To ensure that consecutive X-ray pulses do not probe previously exposed crystals, the sample needs to be replaced with the X-ray repetition rate, which ranges from 120 Hz at warm linac-based free-electron lasers to 1 MHz at superconducting linacs. Liquid injectors are therefore an essential part of a serial femtosecond crystallography experiment at an X-ray free-electron laser. Here, we compare different techniques of injecting microcrystals in solution into the pulsed X-ray beam in vacuum. Sample waste due to mismatch of the liquid flow rate to the X-ray repetition rate can be addressed through various techniques. PMID:24914163

  2. Applications for the RFD linac structure

    NASA Astrophysics Data System (ADS)

    Swenson, Donald A.

    2001-07-01

    With the successful completion and operation of the "Proof-of-Principle" prototype of the Rf Focused Drift tube (RFD) linac structure, our attention has now turned to the identification of the first applications for this new compact and economical linac structure. The principal medical applications are for the production of short-lived radioisotopes for the positron emission tomography (PET and SPECT) application, epithermal neutron beams for the boron neutron capture therapy (BNCT) application, and nanoamperes of energetic (250 MeV) protons for proton therapy. The structure can be configured as a compact injector linac for proton synchrotrons. The structure can be configured as a pulsed cold neutron source to support cold neutron physics and its applications. The principal industrial applications include nondestructive testing (NDT), thermal neutron radiography (TNR), thermal neutron analysis (TNA), and pulsed fast neutron analysis (PFNA). Brief descriptions of these RFD-linac-based systems will be presented.

  3. New HOM coupler design for high current SRF cavity

    SciTech Connect

    Xu, W.; Ben-Zvi, I.; Belomestnykh, S.; Hahn, H.; Johnson, E.

    2011-03-28

    Damping higher order modes (HOMs) significantly to avoid beam instability is a challenge for the high current Energy Recovery Linac-based eRHIC at BNL. To avoid the overheating effect and high tuning sensitivity, current, a new band-stop HOM coupler is being designed at BNL. The new HOM coupler has a bandwidth of tens of MHz to reject the fundamental mode, which will avoid overheating due to fundamental frequency shifting because of cooling down. In addition, the S21 parameter of the band-pass filter is nearly flat from first higher order mode to 5 times the fundamental frequency. The simulation results showed that the new couplers effectively damp HOMs for the eRHIC cavity with enlarged beam tube diameter and 2 120{sup o} HOM couplers at each side of cavity. This paper presents the design of HOM coupler, HOM damping capacity for eRHIC cavity and prototype test results.

  4. T-REX Design Considerations for Detection of Concealed 238U

    SciTech Connect

    Pruet, J; McNabb, D P

    2006-02-07

    Here they outline considerations that might inform choices for the design of a laser/linac-based light source used to detect {sup 238}U via excitation of the resonance at 680.11 keV in this isotope. They assume that the principal concern is speed of interrogation and not, e.g., how much radiological dose is imparted during a scan. It is found that if the photon detectors used in the system have an energy resolution better than or comparable to that of the interrogation beam, then to a first approximation the light source should be designed to have the highest possible specific fluence (photons per unit energy per unit time). there is also a weak dependence of scan time on the number of photons emitted per pulse of the light source. A simple formula describing the tradeoff between specific fluence and number of photons per pulse is presented.

  5. First refraction contrast imaging via Laser-Compton Scattering X-ray at KEK

    SciTech Connect

    Sakaue, Kazuyuki; Aoki, Tatsuro; Washio, Masakazu; Araki, Sakae; Fukuda, Masafumi; Terunuma, Nobuhiro; Urakawa, Junji

    2012-07-31

    Laser-Compton Scattering (LCS) is one of the most feasible techniques for high quality, high brightness, and compact X-ray source. High energy electron beam produced by accelerators scatters off the laser photon at a small spot. As a laser target, we have been developing a pulsedlaser storage cavity for increasing an X-ray flux. The X-ray flux was still inadequate that was 2.1 Multiplication-Sign 10{sup 5}/sec, however, we performed first refraction contrast imaging in order to evaluate the quality of LCS X-ray. Edge enhanced contrast imaging was achieved by changing the distance from sample to detector. The edge enhancement indicates that the LCS X-ray has small source size, i.e. high brightness. We believe that the result has demonstrated good feasibility of linac-based high brightness X-ray sources via laser-electron Compton scatterings.

  6. The Jefferson lab FEL driver ERLs

    SciTech Connect

    Douglas, David R.; Tennant, Christopher D.

    2013-11-01

    Jefferson Lab has - for over a decade - been operating high power IR and UV FELs using CW energy recovering linacs based on DC photocathode electron sources and CEBAF SRF technology. These machines have unique combinations of beam quality, power, and operational flexibility, and thus offer significant opportunity for experiments that use low and medium energy (several tens - few hundreds of MeV) electron beams. We will describe the systems and detail their present and near-term (potential) performance. Recent internal-target analysis and validation testing will be discussed, and schemes for single- and two-pass fixed target operation described. An introduction to subsequent discussions of beam quality and upgrade paths to polarized operation/higher energy will be given.

  7. Total cross section of solid mesitylene, toluene and a mixture of them at thermal neutron energies

    NASA Astrophysics Data System (ADS)

    Rodríguez Palomino, L. A.; Cantargi, F.; Blostein, J. J.; Dawidowski, J.; Granada, J. R.

    2009-01-01

    The total neutron cross sections of mesitylene, toluene and a solution 3:2 by volume of mesitylene and toluene were measured at the electron LINAC based pulsed neutron source of Centro Atómico Bariloche. Measurements were performed at 180 K, 120 K and 31.6 K for mesitylene and at 120 K and 31.6 K for toluene and a solution 3:2 by volume of mesitylene and toluene. The systems are potential moderator materials to be considered in the design of a cold neutron source due to their high resistance to radiation and the richness in low-energy excitations of their frequency spectra, that lead to produce an enhanced cold neutron flux.

  8. The BESSY FEL project

    NASA Astrophysics Data System (ADS)

    Abo-Bakr, M.; Anders, W.; Bahrdt, J.; Bakker, R. J.; Eberhardt, W.; Faatz, B.; Follath, R.; Gaupp, A.; von Hartrott, M.; Jaeschke, E.; Krämer, D.; Kuske, P.; Martin, M.; Müller, R.; Prange, H.; Reiche, S.; Sandner, W.; Senf, F.; Will, I.; Wüstefeld, G.

    2002-05-01

    Berliner Elektronenspeicherring-Gesellschaft für Synchrotronstrahlung (BESSY) plans to construct a linac-based single-pass FEL as an addition to its existing third generation storage-ring-based light-source. The project aims to obtain an FEL-based user-facility that covers the VUV and soft X-ray spectral range (20 eV⩽ℏ ω⩽1 keV). At present, the design stage is funded as a collaboration between BESSY, DESY, the Hahn-Meitner-Institute in Berlin, and the Max-Born-Institute in Berlin. This stage focuses on optimization of the FEL as a user light-source, both with respect to its capabilities and in its performance. Important issues are: stability, seeding options of the SASE FEL, wavelength-tunability, synchronization with external laser sources and, on a longer time-scale, the generation of ultra-short (<20 fs RMS) optical pulses.

  9. Intense terahertz pulses from SPARC_LAB coherent radiation source

    NASA Astrophysics Data System (ADS)

    Giorgianni, F.; Bellaveglia, M.; Castellano, M.; Chiadroni, E.; Cianchi, A.; Daniele, M.; Di Giovenale, D.; Di Pirro, G.; Ferrario, M.; Lupi, S.; Mostacci, A.; Petrarca, M.; Pompili, R.; Shpakov, V.; Villa, F.

    2015-05-01

    The linac-based Terahertz source at the SPARC_LAB test facility is able to generate highly intense Terahertz broadband pulses via coherent transition radiation (CTR) from high brightness electron beams. The THz pulse duration is typically down to 100 fs RMS and can be tuned through the electron bunch duration and shaping. The measured stored energy in a single THz pulse has reached 40 μJ, which corresponds to a peak electric field of 1.6 MV/cm at the THz focus. Here we present the main features, in particular spatial and spectral distributions and energy characterizations of the SPARC_LAB THz source, which is very competitive for investigations in Condensed Matter, as well as a valid tool for electron beam longitudinal diagnostics.

  10. Pulsed Photofission Delayed Gamma Ray Detection for Nuclear Material Identification

    SciTech Connect

    John Kavouras; Xianfei Wen; Daren R. Norman; Dante R. Nakazawa; Haori Yang

    2012-11-01

    Innovative systems with increased sensitivity and resolution are in great demand to detect diversion and to prevent misuse in support of nuclear materials management for the U.S. fuel cycle. Nuclear fission is the most important multiplicative process involved in non-destructive active interrogation. This process produces the most easily recognizable signature for nuclear materials. High-energy gamma rays can also excite a nucleus and cause fission through a process known as photofission. After photofission reactions, delayed signals are easily distinguishable from the interrogating radiation. Linac-based, advanced inspection techniques utilizing the fission signals after photofission have been extensively studied for homeland security applications. Previous research also showed that a unique delayed gamma ray energy spectrum exists for each fissionable isotope. Isotopic composition measurement methods based on delayed gamma ray spectroscopy will be the primary focus of this work.

  11. A Superconducting Linac Proton Driver at Fermilab

    NASA Astrophysics Data System (ADS)

    Foster, G. William

    2004-05-01

    A proton driver has emerged as the leading candidate for Fermilab's next near-term accelerator project. The preferred technical solution is an 8 GeV superconducting linac based on technology developed for TESLA and the Spallation Neutron Source (SNS). Its primary mission is to serve as a single-stage H- injector to prepare 2 MW "Super-Beams" for Neutrino experiments using the Fermilab Main Injector. The linac can also accelerate electrons, protons, and relativistic muons, permitting future applications such as a driver for an FEL, a long-pulse spallation source, the driver for an intense 8 GeV neutrino or kaon program, and potential applications to a neutrino factory or muon collider. The technical design of the 8 GeV linac, as well as the design of an alternative synchrotron based proton driver, will be described along with plans for project proposal and construction.

  12. European Xfel-Linac Two-Phase he II Flow Simulations

    NASA Astrophysics Data System (ADS)

    Gubarev, V.; Petersen, B.; Sellmann, D.; Xiang, Y.

    2008-03-01

    The superconducting 1.3-GHz niobium cavities of the XFEL linear accelerator will be cooled in a bath of saturated liquid He II at a temperature of 2 K. The liquid He II supply of the 1.7-km long linac is subdivided in sections of about 150 m length. In these sections a two-phase flow of He II liquid and corresponding vapor occurs. A stable stratified smooth helium flow has to be maintained for the RF operation of the cavities, to avoid any vibrations or microphonic effects. A computer code has been developed to simulate the two-phase flow patterns in the XFEL-linac, based on an existing model. The flow characteristics at different cryogenic loads and helium temperatures have been calculated. The results are shown and the consequences for the design of the XFEL-linac cryogenic system are discussed.

  13. CONCEPTUAL DESIGN OF A LOW-BETA SC PROTON LINAC

    SciTech Connect

    R. W. GARNETT; T. P WANGLER; ET AL

    2001-04-01

    In this paper we discuss the conceptual design of a low-{beta} superconducting proton linac based on multi-gap spoke resonator structures. We have demonstrated the feasibility of using superconducting accelerating structures throughout a proton linac for high-peak current applications. The injection energy for this linac is assumed to be 6.7 MeV, which equals the output energy of the CW RFQ built for the Low-Energy Demonstration Accelerator now operating at Los Alamos. The beam is accelerated to 109 MeV using multi-gap spoke resonators. Both 2-gap and 3-gap cavities are used in three accelerating sections with geometric-{beta} values of 0.175, 0.2, and 0.34. Higher beam energies can be achieved by transitioning to elliptical superconducting cavities to further accelerate the beam. Preliminary beam-dynamics simulation results are shown and discussed.

  14. Parallel Beam Dynamics Simulation Tools for Future Light SourceLinac Modeling

    SciTech Connect

    Qiang, Ji; Pogorelov, Ilya v.; Ryne, Robert D.

    2007-06-25

    Large-scale modeling on parallel computers is playing an increasingly important role in the design of future light sources. Such modeling provides a means to accurately and efficiently explore issues such as limits to beam brightness, emittance preservation, the growth of instabilities, etc. Recently the IMPACT codes suite was enhanced to be applicable to future light source design. Simulations with IMPACT-Z were performed using up to one billion simulation particles for the main linac of a future light source to study the microbunching instability. Combined with the time domain code IMPACT-T, it is now possible to perform large-scale start-to-end linac simulations for future light sources, including the injector, main linac, chicanes, and transfer lines. In this paper we provide an overview of the IMPACT code suite, its key capabilities, and recent enhancements pertinent to accelerator modeling for future linac-based light sources.

  15. Free-electron laser sources of extreme-ultraviolet radiation and their vacuum requirements

    SciTech Connect

    Newnam, B.E.

    1990-01-01

    Recent development of free-electron laser (FEL) component technologies should enable these devices to operate in the extreme-ultraviolet, well below 100 nm. When fully developed, FELs represent the next generation of coherent-radiation sources with peak- and average-power outputs surpassing those of any existing, continuously tunable photon source by many orders of magnitude. An rf-linac-based, multiple-FEL facility, spanning the spectral range from 1 nm to 100 {mu}m, is proposed. To enable such a facility to operate without significant degradation over long periods, contamination of certain of the FEL components must be prevented. Requirements for ultra-high vacuum and restricted contamination from outgassing from chamber walls are discussed. 73 refs., 11 figs., 4 tabs.

  16. Design of RF chopper system for improving beam quality in FEL injector with thermionic gun

    NASA Astrophysics Data System (ADS)

    Chen, Q.; Qin, B.; Tan, P.; Hu, T.; Pei, Y.; Zhang, F.

    2014-08-01

    For a linac-based Free Electron Laser (FEL), good beam quality largely contributes to the success of the final radiation. An imperfection confronted with the HUST THz-FEL facility is the long beam tail that emerges in the electron gun and exists through the whole beam line. This paper proposes to deploy a chopper system after the electron gun to truncate the beam tails before they enter into the linac. Physical dimensions of the chopper cavity are discussed in detail and we have developed and derived new analytical expressions applying to all frequencies for the optimal design. Also, technical issues of the cavity are considered. Beam dynamic simulation is performed to examine the truncation effect and the results show that more than 78% of the beam tail can be removed effectively, while preserving the emittance and energy spread in acceptable level.

  17. Compact x-ray lasers in the laboratory

    SciTech Connect

    Barletta, W.A.

    1988-10-03

    Compact x-ray lasers in the laboratory can be produced with ultrahigh gradient rf linacs based on recent advances in linac technology by an SLAC-LLNL-LBL collaboration and on the development of bright, high current electron sources by BNL and LANL. The GeV electron beams generated with such accelerators can be converted to soft x rays in the range of 2--10 nm by passage through short period, high field strength wigglers. Alternatively, the beam can pump a low density dielectric to produce x rays via recombination. Such linear light sources can produce trains of picosecond (or shorter) pulses of extremely high spectral brilliance suitable for flash holography of biological specimens in vivo and for studies of fast chemical reactions. 15 refs., 7 figs., 3 tabs.

  18. Modeling and simulation of laser systems; Proceedings of the Meeting, Los Angeles, CA, Jan. 17, 18, 1989

    SciTech Connect

    Bullock, D.L.

    1989-01-01

    Various papers on modeling and simulation of laser systems are presented. Individual topics addressed include: simulations of FELs, three-dimensional nonlinear simulation of the FEL, modeling of induction-linac-based FEL amplifiers, simulation codes for modeling FEL oscillators, FELs using stable-unstable ring resonators, computational analysis of Raman look-through adaptive optics, modeling optical parametric amplifiers, large multimode stable resonator propagation, modeling paraxial diffraction using orthogonal mode decompositions, laser beam propagation for interplanetary high data rate communication links, mirror surface aberrations and mixing efficiency, beam propagation through a refracting surface, semiclassical modeling and analysis of injected lasers, theory of ring lasers coupled using reverse waves, amplified spontaneous emission effects in laser amplifiers, modeling of the HF overtone chemical laser, and numerical simulation of single-strip diode lasers.

  19. Free Electron Lasers - Proceedings of the Beijing Fel Seminar

    NASA Astrophysics Data System (ADS)

    Chen, Jiaer; Xie, Jialin; Du, Xiangwan; Zhao, Kui

    1989-03-01

    The Table of Contents for the full book PDF is as follows: * Preface to the Series * Preface * Seminar Opening Speech * Seminar Closing Address * SECTION 1. RF LINAC BASED FEL * Richard H. Pantell * Free-Electron Lasers * Gas-Loading the FEL * High-Efficiency, High-Power Free-Electron Lasers * A Tunable Submillimeter-to-Far-Infrared Coherent Radiation Source * Kwok-Chi Dominic Chan * Recent Results from the Los Alamos Free Electron Laser * Short-Range Wakefield Effects in RF-Based Free-Electron Laser * Long-Range Wakefield Effects in RF-Based Free-Electron Laser * High-Brightness Injectors For RF-Driven Free-Electron Lasers * Computer Codes for Wakefield Analysis in RF-Based Free-Electron Laser * George R. Neil * The TRW RF Accelerator FEL Program * Superconducting Linac FEL Technology * Design Considerations of RF Oscillators * Chun-Ching Shih * Development of Multicomponent Wiggler Free Electron Lasers * Free Electron Laser Resonator * SECTION 2. INDUCTION LINAC BASED FEL * Richard J. Briggs * Overview of FEL Development with Induction Linacs at LLNL * Overview of Linear Induction Accelerators * High Current Electron-Beam Transport in Induction Linacs * Thaddeus J. Orzechowski * An Introduction to the Physics of High-Gain Free-Electron Lasers * Harmonics and Optical Guiding in Free Electron Lasers * The Electron Laser Facility: A millimeter Wave Free-Electron Laser Amplifier * The Electron Laser Facility: Measurement of Modes, Harmonics, Parametric Dependence, and Phase Shift * Paladin: A 10.6 μm Free-Electron Laser Amplifier * Aspects of Linear Induction Accelerator Technology * List of Participants

  20. Comparison of the extent of hippocampal sparing according to the tilt of a patient's head during WBRT using linear accelerator-based IMRT and VMAT.

    PubMed

    Moon, Sun Young; Yoon, Myonggeun; Chung, Mijoo; Chung, Weon Kuu; Kim, Dong Wook

    2016-05-01

    In this paper, we report the results of our investigation into whole brain radiotherapy (WBRT) using linear accelerator-based intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) in lung cancer patients with a high risk of metastasis to the brain. Specifically, we assessed the absorbed dose and the rate of adverse effects for several organs at risk (OAR), including the hippocampus, according to the tilt of a patient's head. We arbitrarily selected five cases where measurements were made with the patients' heads tilted forward and five cases without such tilt. We set the entire brain as the planning target volume (PTV), and the hippocampi, the lenses, the eyes, and the cochleae as the main OAR, and formulated new plans for IMRT (coplanar, non-coplanar) and VMAT (coplanar, non-coplanar). Using the dose-volume histogram (DVH), we calculated and compared the effective uniform dose (EUD), normal tissue complication probability (NTCP) of the OAR and the mean and the maximum doses of hippocampus. As a result, if the patient tilted the head forward when receiving the Linac-based treatment, for the same treatment effect in the PTV, we confirmed that a lower dose entered the OAR, such as the hippocampus, eye, lens, and cochlea. Moreover, the damage to the hippocampus was expected to be the least when receiving coplanar VMAT with the head tilted forward. Accordingly, if patients tilt their heads forward when undergoing Linac-based WBRT, we anticipate that a smaller dose would be transmitted to the OAR, resulting in better quality of life following treatment. PMID:27133139

  1. WE-B-19A-01: SRT II: Uncertainties in SRT

    SciTech Connect

    Dieterich, S; Schlesinger, D; Geneser, S

    2014-06-15

    SRS delivery has undergone major technical changes in the last decade, transitioning from predominantly frame-based treatment delivery to imageguided, frameless SRS. It is important for medical physicists working in SRS to understand the magnitude and sources of uncertainty involved in delivering SRS treatments for a multitude of technologies (Gamma Knife, CyberKnife, linac-based SRS and protons). Sources of SRS planning and delivery uncertainty include dose calculation, dose fusion, and intra- and inter-fraction motion. Dose calculations for small fields are particularly difficult because of the lack of electronic equilibrium and greater effect of inhomogeneities within and near the PTV. Going frameless introduces greater setup uncertainties that allows for potentially increased intra- and interfraction motion, The increased use of multiple imaging modalities to determine the tumor volume, necessitates (deformable) image and contour fusion, and the resulting uncertainties introduced in the image registration process further contribute to overall treatment planning uncertainties. Each of these uncertainties must be quantified and their impact on treatment delivery accuracy understood. If necessary, the uncertainties may then be accounted for during treatment planning either through techniques to make the uncertainty explicit, or by the appropriate addition of PTV margins. Further complicating matters, the statistics of 1-5 fraction SRS treatments differ from traditional margin recipes relying on Poisson statistics. In this session, we will discuss uncertainties introduced during each step of the SRS treatment planning and delivery process and present margin recipes to appropriately account for such uncertainties. Learning Objectives: To understand the major contributors to the total delivery uncertainty in SRS for Gamma Knife, CyberKnife, and linac-based SRS. Learn the various uncertainties introduced by image fusion, deformable image registration, and contouring

  2. Monolithic silicon photonics in a sub-100nm SOI CMOS microprocessor foundry: progress from devices to systems

    NASA Astrophysics Data System (ADS)

    Popović, Miloš A.; Wade, Mark T.; Orcutt, Jason S.; Shainline, Jeffrey M.; Sun, Chen; Georgas, Michael; Moss, Benjamin; Kumar, Rajesh; Alloatti, Luca; Pavanello, Fabio; Chen, Yu-Hsin; Nammari, Kareem; Notaros, Jelena; Atabaki, Amir; Leu, Jonathan; Stojanović, Vladimir; Ram, Rajeev J.

    2015-02-01

    We review recent progress of an effort led by the Stojanović (UC Berkeley), Ram (MIT) and Popović (CU Boulder) research groups to enable the design of photonic devices, and complete on-chip electro-optic systems and interfaces, directly in standard microelectronics CMOS processes in a microprocessor foundry, with no in-foundry process modifications. This approach allows tight and large-scale monolithic integration of silicon photonics with state-of-the-art (sub-100nm-node) microelectronics, here a 45nm SOI CMOS process. It enables natural scale-up to manufacturing, and rapid advances in device design due to process repeatability. The initial driver application was addressing the processor-to-memory communication energy bottleneck. Device results include 5Gbps modulators based on an interleaved junction that take advantage of the high resolution of the sub-100nm CMOS process. We demonstrate operation at 5fJ/bit with 1.5dB insertion loss and 8dB extinction ratio. We also demonstrate the first infrared detectors in a zero-change CMOS process, using absorption in transistor source/drain SiGe stressors. Subsystems described include the first monolithically integrated electronic-photonic transmitter on chip (modulator+driver) with 20-70fJ/bit wall plug energy/bit (2-3.5Gbps), to our knowledge the lowest transmitter energy demonstrated to date. We also demonstrate native-process infrared receivers at 220fJ/bit (5Gbps). These are encouraging signs for the prospects of monolithic electronics-photonics integration. Beyond processor-to-memory interconnects, our approach to photonics as a "More-than- Moore" technology inside advanced CMOS promises to enable VLSI electronic-photonic chip platforms tailored to a vast array of emerging applications, from optical and acoustic sensing, high-speed signal processing, RF and optical metrology and clocks, through to analog computation and quantum technology.

  3. Devices and systems-on-chip for photonic communication links in a microprocessor

    NASA Astrophysics Data System (ADS)

    Wade, Mark T.

    For the first time, high-performance photonic devices and electronic-photonic systems-on-chip are monolithically integrated in an advanced CMOS microelectronics fabrication process. This includes a silicon optical resonator termed the "spoked-ring" cavity that meets the constraints of thin-SOI microelectronics CMOS processes and enables energy efficient modulators and thermally tunable filters. For low-loss fiber-to-chip optical coupling, a phased-array antenna concept is demonstrated, and the 45 nm CMOS microelectronics process is shown to support a near ideal implementation of the device using the crystalline silicon and polysilicon material layers that comprise the active region and gate, respectively, of the native MOSFET transistors. The active devices and vertical grating couplers are implemented in large-scale electronic-photonic systems-on-chip to demonstrate a wavelength stabilized, microring-based chip-to-chip communications link and an 11-channel wavelength division multiplexed (WDM) transmitter. The link is shown to be robust against thermal environmental variations which is critical for operation in realistic systems. The chip-to-chip link is then used to demonstrate a CPU-to-memory communication link, the first demonstration of its kind. The first microprocessor with photonic I/O is demonstrated as part of this work, with substantial implications for computer architecture. Advanced photonic device technology demonstrations, including photonic crystals, a quantum-correlated photon-pair source, an active photonic device platform in a 32 nm SOI node, and a 180 nm bulk silicon process, are presented to show the wide range of applications that monolithic integration could support in the future of photonics. These results taken together show that monolithic integration directly into CMOS microelectronics processes does allow high performance photonics, and is a viable approach to build large-scale electronic-photonic systems with a realistic path to

  4. π 0 and η Photoproduction on the Deuteron at ELPH, Tohoku University

    NASA Astrophysics Data System (ADS)

    Ishikawa, T.; Fujimura, H.; Fukasawa, H.; Hashimoto, R.; He, Q.; Honda, Y.; Iwata, T.; Kaida, S.; Kasagi, J.; Kawano, A.; Kuwasaki, S.; Maeda, K.; Masumoto, S.; Miyabe, M.; Miyahara, F.; Mochizuki, K.; Muramatsu, N.; Nakamura, A.; Nawa, K.; Ogushi, S.; Okada, Y.; Onodera, Y.; Ozawa, K.; Sakamoto, Y.; Sato, M.; Shimizu, H.; Sugai, H.; Suzuki, K.; Tajima, Y.; Takahashi, S.; Taniguchi, Y.; Tsuchikawa, Y.; Yamazaki, H.; Yamazaki, R.; Yoshida, H. Y.

    2013-08-01

    Baryon spectroscopy is important to understand Quantum Chromodynamics at low energies. In this purpose, a series of π 0 and η photoproduction experiments was carried out with an electro-magnetic calorimeter FOREST at Research Center for Electron Photon Science, Tohoku University. The incident tagged bremsstrahlung photon energy ranges from 550 to 1,150 MeV. The differential and total cross sections obtained for π 0 and η photoproduction processes on the proton are consistent with the SAID and MAID calculations. The analysis of π 0 and η photoproduction on the neutron is underway.

  5. Study of Double Delta Photoproduction on the Deuteron in the Energy Region of Eγ = 0.65-1.1 GeV

    NASA Astrophysics Data System (ADS)

    Yamamoto, Fumiya; Beckford, Brian; Fujibayashi, Takeji; Fujii, Takao; Fujii, Yu; Futatsukawa, Kenta; Gogami, Toshiyuki; Han, Yun-Cheng; Hashimoto, Osamu; Hirose, Kentaro; Hosomi, Kenji; Honda, Ryotaro; Iguchi, Alan; Ishikawa, Takatsugu; Kanda, Hiroki; Kaneta, Masashi; Kaneko, Yusuke; Kawasaki, Taito; Kimura, Chigusa; Kiyokawa, Shogo; Koike, Takeshi; Maeda, Kazushige; Maruyama, Nayuta; Matsubara, Masao; Miwa, Koji; Miyagi, Yohei; Nagao, Sho; Nakamura, Satoshi N.; Okuyama, Akira; Shimizu, Hajime; Suzuki, Kotaku; Tamae, Tadaaki; Tamura, Hirokazu; Tsukada, Kyo; Terada, Nobu; Ukai, Mifuyu; Wang, Tie-Shan; Yamazaki, Hirohito

    We have studied π+ π- photoproduction on the deuteron in an energy region of Eγ = 0.65-1.1 GeV at Research Center for Electron Photon Science (ELPH), Tohoku University. The charged particles were detected using Neutral Kaon Spectrometer 2 (NKS2). The invariant mass distributions reconstructed from the π+ p and π-n combinations suggested the double Delta excitations in the intermediate state. There distributions were compared with simulations taking into account the Δ+ +Δ- → π+π-pn, the Δ+Δ0 → π+π-pn, and the 4 body phase space.

  6. Study of γ d → π + π - d Reaction in an Energy Region of 0.67 ≤ E γ ≤ 1.08 GeV

    NASA Astrophysics Data System (ADS)

    Kimura, C.; Beckford, B.; Fujibayashi, T.; Fujii, T.; Fujii, Y.; Futatsukawa, K.; Gogami, T.; Hashimoto, O.; Han, Y. C.; Hirose, K.; Honda, R.; Hosomi, K.; Iguchi, A.; Ishikawa, T.; Kanda, H.; Kaneko, Y.; Kaneta, M.; Kasai, Y.; Kawasaki, T.; Kiyokawa, S.; Koike, T.; Maeda, K.; Matsubara, N.; Miwa, K.; Miyagi, Y.; Nagao, S.; Nakamura, S. N.; Okuyama, A.; Shimizu, H.; Tamae, T.; Tamura, H.; Terada, N.; Tsukada, K.; Yamamoto, F.; Yamamoto, T. O.; Yamazaki, H.

    2013-08-01

    Double charged pion photoproductions from the deuteron have been studied at Research Center for Electron Photon Science (ELPH), Tohoku University. Tagged photon beams in an energy range of 0.67 ≤ E γ ≤ 1.08 GeV were impinged on the liquid deuteron target. Produced charged particles were observed with the Neutral Kaon Spectrometer2 (NKS2). The γ d → π + π - d process was clearly separated among the three charged tracks. We obtained the photon energy dependence of the normalized yields of this process.

  7. Triggering with the LHCb calorimeters

    NASA Astrophysics Data System (ADS)

    Lefevre, Regis; LHCb Collaboration

    2009-04-01

    The LHCb experiment at the LHC has been conceived to pursue high precision studies of CP violation and rare phenomena in b hadron decays. The online selection is crucial in LHCb and relies on the calorimeters to trigger on high transverse energy electrons, photons, π0 and hadrons. In this purpose a dedicated electronic has been realized. The calorimeter trigger system has been commissioned and is used to trigger on cosmic muons before beams start circulating in the LHC. When the LHC will start, it will also provide a very useful interaction trigger.

  8. The CMS High-Level Trigger

    SciTech Connect

    Covarelli, R.

    2009-12-17

    At the startup of the LHC, the CMS data acquisition is expected to be able to sustain an event readout rate of up to 100 kHz from the Level-1 trigger. These events will be read into a large processor farm which will run the 'High-Level Trigger'(HLT) selection algorithms and will output a rate of about 150 Hz for permanent data storage. In this report HLT performances are shown for selections based on muons, electrons, photons, jets, missing transverse energy, {tau} leptons and b quarks: expected efficiencies, background rates and CPU time consumption are reported as well as relaxation criteria foreseen for a LHC startup instantaneous luminosity.

  9. Hanbury Brown-Twiss correlations to probe the population statistics of GHz photons emitted by conductors.

    PubMed

    Gabelli, J; Reydellet, L-H; Fève, G; Berroir, J-M; Plaçais, B; Roche, P; Glattli, D C

    2004-07-30

    We present the first study of the statistics of GHz photons in quantum circuits, using Hanbury Brown and Twiss correlations. The super-Poissonian and Poissonian photon statistics of thermal and coherent sources, respectively, made of a resistor and a radio frequency generator, are measured down to the quantum regime at milli-Kelvin temperatures. As photon correlations are linked to the second and fourth moments of current fluctuations, this experiment, which is based on current cryogenic electronics, may become a standard for probing electron/photon statistics in quantum conductors. PMID:15323720

  10. Relativistic dynamics of the Compton diffusion on a bound electron

    NASA Astrophysics Data System (ADS)

    Al Saleh, Salwa

    2016-05-01

    A covariant relativistic formalism for the electron-photon and nuclear dynamics is summarised making more accurate predictions in agreement with experiments for Compton scattering in shells with large electron binding energy. An exact solution for the Dirac equation for an electron in the nuclear Coulomb field is obtained, in order to write the relativistic dynamics for this QED process. This is a preparation for the calculation of the relativistic cross-section for Compton scattering on bound electrons, as a precision test for QED.

  11. Surface state photoelectrons in topological insulators: Green’s function approach

    NASA Astrophysics Data System (ADS)

    Schmeltzer, D.; Saxena, A.

    2015-12-01

    We compute the photoemission intensity and polarization for the surface states in topological insulators. Due to the chirality and linear energy dispersion the effective electron-photon coupling is normalized by the tunneling amplitude (τ) into the vacuum. We investigate a chiral Dirac Hamiltonian for different cases: helical, Zeeman and warping, allowing us to study spin textures. Using the Green’s function formalism we obtain exact results for the emitted photoelectrons to second order in the laser field. The number of emitted photoelectrons is sensitive to the laser coherent state intensity whereas the photoelectron polarization is sensitive to the surface topology of electronic states and incoming photon polarization.

  12. Application Of Cathode-Ray Tube Technology To The Clinical Evaluation Of Visual Functions

    NASA Astrophysics Data System (ADS)

    Vernier, Francoise; Charlier, Jacques; Nguyen, Duc D.

    1988-02-01

    Cathode-ray tubes (CRTs) have many applications in the clinical evaluation of visual functions. They have been used to test visual acuity, contrast sensitivity, visual fields, and early development of vision in preverbal children. Because CRTs provide considerable flexibility for the definition of spatial and temporal components of the stimulus, their use provides an attractive solution to many visual stimulation problems. However, there are some limitations due to the scanning of the picture frame by the electron beam and also to the electron-photon conversion process. The spatial, photometric, spectral, and temporal characteristics of a specifically designed monochromatic television system are evaluated with reference to the physiological requirements of visual tests.

  13. Research Laboratory of Electronics

    NASA Astrophysics Data System (ADS)

    Allen, J.

    1983-01-01

    Partial Contents: Molecule Microscopy; Semiconductor Surface Studies; Atomic Resonance and Scattering; Reaction Dynamics at Semiconductor Surfaces; X-Ray Diffuse Scattering; Phase Transition in Chemisorbed Systems; Optics and Quantum Electronics; Photonics; Optical Spectroscopy of Disordered Materials and X-Ray Scattering from Surfaces; Infrared Nonlinear Optics; Quantum Optics and Electronics; Microwave and Millimeter Wave Techniques; Microwave and Quantum Magnetics; Radio Astronomy; Electromagnetic Wave Theory and Remote Sensing; Electronic Properties of Amorphous Silicon Dioxide; Photon Correlation Spectroscopy and Applications; Submicron Structures Fabrication and Research; Plasma Dynamics; Optical Propagation and Communication; Digital Signal Processing Group; Speech Communication; Linguistics; Cognitive Information Processing; Custom Integrated Circuits; Communications Biophysics; and Physiology.

  14. Project objectives and progress at the Research Laboratory of Electronics

    NASA Astrophysics Data System (ADS)

    Allen, J.

    1983-01-01

    Molecule microscopy, semiconductor surface studies, atomic resonance and scattering, reaction dynamics at semiconductor surfaces, X-ray diffuse scattering, phase transitions in chemisorbed systems, optics and quantum electronics, photonics, optical spectroscopy of disordered materials and X-ray scattering from surfaces, infrared nonlinear optics, quantum optics and electronics, microwave and millimeter wave techniques, microwave and quantum magnetics, radio astronomy, electromagnetic wave theory and remote sensing, electronic properties of amorphous silicon dioxide, photon correlation spectroscopy and applications, submicron structures fabrication, plasma dynamics, optical propagation and communication, digital signal processing, speech communication, linguistics, cognitive information processing, custom integrated circuits, communications biophysics, and physiology, are discussed.

  15. Surface state photoelectrons in topological insulators: Green's function approach.

    PubMed

    Schmeltzer, D; Saxena, A

    2015-12-01

    We compute the photoemission intensity and polarization for the surface states in topological insulators. Due to the chirality and linear energy dispersion the effective electron-photon coupling is normalized by the tunneling amplitude (τ) into the vacuum. We investigate a chiral Dirac Hamiltonian for different cases: helical, Zeeman and warping, allowing us to study spin textures. Using the Green's function formalism we obtain exact results for the emitted photoelectrons to second order in the laser field. The number of emitted photoelectrons is sensitive to the laser coherent state intensity whereas the photoelectron polarization is sensitive to the surface topology of electronic states and incoming photon polarization. PMID:26565417

  16. Two-electron photoionization of ground-state lithium

    SciTech Connect

    Kheifets, A. S.; Fursa, D. V.; Bray, I.

    2009-12-15

    We apply the convergent close-coupling (CCC) formalism to single-photon two-electron ionization of the lithium atom in its ground state. We treat this reaction as single-electron photon absorption followed by inelastic scattering of the photoelectron on a heliumlike Li{sup +} ion. The latter scattering process can be described accurately within the CCC formalism. We obtain integrated cross sections of single photoionization leading to the ground and various excited states of the Li{sup +} ion as well as double photoionization extending continuously from the threshold to the asymptotic limit of infinite photon energy. Comparison with available experimental and theoretical data validates the CCC model.

  17. Methodology exploration of specimen preparation for atom probe tomography from nanowires.

    PubMed

    Qu, Jiangtao; Wong, Derek; Du, Sichao; Yang, Limei; Ringer, Simon; Zheng, Rongkun

    2015-12-01

    Semiconductor nanowires have been intensively explored for applications in electronics, photonics, energy conversion and storage. A fundamental and quantitative understanding of growth-structure-property relationships is central to applications where nanowires exhibit clear advantages. Atom Probe Tomography (APT) is able to provide 3 dimensional quantitative elemental distributions at atomic-resolution and is therefore unique in understanding the growth-structure-property relationships. However, the specimen preparation with nanowires is extremely challenging. In this paper, two ion beam free specimen preparation methods for APT are presented which are efficient for various nanowires. PMID:26119926

  18. Experiment Pamir-3. Coplanar emission of high energy gamma-quanta at interaction of hadrons with nuclei of air atoms at energies above 10 to the 7th power GeV

    NASA Technical Reports Server (NTRS)

    Genina, L. E.; Asatiani, T. L.; Zatsepin, G. T.

    1985-01-01

    A systematic analysis of large gamma families, detected in X-ray emulsion chambers, cases of multicore halos have been observed, and among them five events in which the halo is divided into three of four separate cores with their alignment observed in the target diagram (coplanarity of axes of corresponding electron photon cascades). The halo alignment (tendency to the straight line) leads to the aximuthal asymmetry (thrust). The analysis of lateral and momentum distributions of particles in these families shows that they also have thrust that correlates with the direction of the halo core alignment.

  19. Testing technology

    SciTech Connect

    Not Available

    1993-10-01

    This bulletin from Sandia National Laboratories presents current research highlights in testing technology. Ion microscopy offers new nondestructive testing technique that detects high resolution invisible defects. An inexpensive thin-film gauge checks detonators on centrifuge. Laser trackers ride the range and track helicopters at low-level flights that could not be detected by radar. Radiation transport software predicts electron/photon effects via cascade simulation. Acoustic research in noise abatement will lead to quieter travelling for Bay Area Rapid Transport (BART) commuters.

  20. Diamonds for beam instrumentation

    SciTech Connect

    Griesmayer, Erich

    2013-04-19

    Diamond is perhaps the most versatile, efficient and radiation tolerant material available for use in beam detectors with a correspondingly wide range of applications in beam instrumentation. Numerous practical applications have demonstrated and exploited the sensitivity of diamond to charged particles, photons and neutrons. In this paper, a brief description of a generic diamond detector is given and the interaction of the CVD diamond detector material with protons, electrons, photons and neutrons is presented. Latest results of the interaction of sCVD diamond with 14 MeV mono-energetic neutrons are shown.

  1. Photon gluon fusion cross sections at HERA energy

    NASA Astrophysics Data System (ADS)

    Engelen, J. J.; Dejong, S. J.; Poletiek, M.; Vermaseren, J. A. M.

    1988-01-01

    Cross sections for heavy flavor production through photon gluon fusion in electron proton collisions are presented. The electron photon vertex is taken into account explicitly, and the Q sq of the exchanged photon ranges from nearly zero (almost real photon) to the kinematically allowed maximum. The QCD scale is set by the mass of the produced quarks. The formalism is also applicable to the production of light quarks as long as the invariant mass of the pair is sufficiently high, so cross sections for u anti-u, d anti-d, and s anti-s production are also given.

  2. Meson Photoproduction Experiments at ELPH, Tohoku University

    NASA Astrophysics Data System (ADS)

    Ishikawa, Takatsugu; Fujimura, Hisako; Fukasawa, Hiroshi; Hashimoto, Ryo; He, Qinghua; Honda, Yuki; Iwata, Takahiro; Kaida, Shun; Kasagi, Jirohta; Kawano, Atsushi; Kuwasaki, Shuzo; Maeda, Kazushige; Masumoto, Shin'ichi; Miyabe, Manabu; Miyahara, Fusashi; Mochizuki, Kei'ichi; Muramatsu, Norihito; Nakamura, Akihiko; Nawa, Ken'ichi; Ogushi, Shoei; Okada, Yasuyuki; Onodera, Yoshihito; Ozawa, Kyoichiro; Sakamoto, Yasunobu; Sato, Mamoru; Shimizu, Hajime; Sugai, Hiroyuki; Suzuki, Koutaku; Tajima, Yasuhisa; Takahashi, Shin'ichiro; Taniguchi, Yusuke; Tsuchikawa, Yusuke; Yamazaki, Hirohito; Yamazaki, Ryuji; Yoshida, Hiroshi Y.

    Meson photoproduction experiments have been conducted with an electromagnetic (EM) calorimeter FOREST at Research Center for Electron Photon Science (ELPH), Tohoku University. A narrow resonance observed at W = 1670 MeV in η photoproduction on the neutron is of great interest, which is a candidate of an anti-decuplet pentaquark baryon although its origin is still controversial. The preliminary results of the cross sections for π0 and η photoproduction on the deuteron are presented. The next generation FOREST experiments have been planned to study S11(1535) properties in the nuclear medium by searching for η-mesic nucleus states. The planned experiments are also shown in this contribution.

  3. Functionalization of Two-Dimensional Transition-Metal Dichalcogenides.

    PubMed

    Chen, Xin; McDonald, Aidan R

    2016-07-01

    Two-dimensional (2D) layered transition-metal dichalcogenides (TMDs) are a fascinating class of nanomaterials that have the potential for application in catalysis, electronics, photonics, energy storage, and sensing. TMDs are rather inert, and thus pose problems for chemical derivatization. However, to further modify the properties of TMDs and fully harness their capabilities, routes towards their chemical functionalization must be identified. Herein, recent efforts toward the chemical (bond-forming) functionalization of 2D TMDs are critically reviewed. Recent successes are highlighted, along with areas where further detailed analyses and experimentation are required. This burgeoning field is very much in its infancy but has already provided several important breakthroughs. PMID:26848815

  4. Materials for Flexible, Stretchable Electronics: Graphene and 2D Materials

    NASA Astrophysics Data System (ADS)

    Kim, Sang Jin; Choi, Kyoungjun; Lee, Bora; Kim, Yuna; Hong, Byung Hee

    2015-07-01

    Recently, 2D materials have been intensively studied as emerging materials for future electronics, including flexible electronics, photonics, and electrochemical energy storage devices. Among representative 2D materials (such as graphene, boron nitride, and transition metal dichalcogenides) that exhibit extraordinary properties, graphene stands out in the flexible electronics field due to its combination of high electron mobility, high thermal conductivity, high specific surface area, high optical transparency, excellent mechanical flexibility, and environmental stability. This review covers the synthesis, transfer, and characterization methods of graphene and 2D materials and graphene's application to flexible devices as well as comparison with other competing materials.

  5. Beta/gamma test problems for ITS. [Integrated Tiger Series (ITS)

    SciTech Connect

    Mei, G.T.

    1993-01-01

    The Integrated Tiger Series of Coupled Electron/Photon Monte Carlo Transport Codes (ITS 3.0, PC Version) was used at Oak Ridge National Laboratory (ORNL) to compare with and extend the experimental findings of the beta/gamma response of selected health physics instruments. In order to assure that ITS gives correct results, several beta/gamma problems have been tested. ITS was used to simulate these problems numerically, and results for each were compared to the problem's experimental or analytical results. ITS successfully predicted the experimental or analytical results of all tested problems within the statistical uncertainty inherent in the Monte Carlo method.

  6. Angular correlations in radiative cascades following resonant electron capture by highly charged ions

    SciTech Connect

    Matula, O.; Surzhykov, A.; Fritzsche, S.; Currell, F. J.

    2011-11-15

    We investigate the angular correlations between the photons emitted in the dielectronic recombination (DR) of initially hydrogenlike heavy ions. The theoretical analysis is performed based on a density-matrix approach and Dirac's relativistic theory. Special emphasis has been placed upon the effects of the higher-order, nondipole terms in the expansion of the electron-photon interaction. To illustrate these effects, we present and discuss detailed calculations for K-LL DR of initially hydrogenlike xenon, gold, and uranium. These computations show that the angular correlations are significantly affected by interference between the leading electric-dipole (E1) and the magnetic-quadrupole (M2) transitions.

  7. Experimental Search for a Heavy Electron

    DOE R&D Accomplishments Database

    Boley, C. D.; Elias, J. E.; Friedman, J. I.; Hartmann, G. C.; Kendall, H. W.; Kirk, P.N.; Sogard, M. R.; Van Speybroeck, L. P.; de Pagter, J. K.

    1967-09-01

    A search for a heavy electron of the type considered by Low and Blackmon has been made by studying the inelastic scattering of 5 BeV electrons from hydrogen. The search was made over a range of values of the mass of the heavy electron from 100 t0 1300 MeV. No evidence for such a particle was observed. Upper limits on the production cross sections were determined and employed to deducelimits on the values of the electron-photon-heavy electron coupling constant in Low and Blackmon=s theory.

  8. CEPXS

    Energy Science and Technology Software Center (ESTSC)

    2015-10-19

    CEPXS is a multigroup-Legendre cross-section generating code. The cross sections produced by CEPXS enable coupled electron-photon transport calculations to be performed with multigroup radiation transport codes, e.g. MITS and SCEPTRE. CEPXS generates multigroup-Legendre cross sections for photons, electrons and positrons over the energy range from 100 MeV to 1.0 keV. The continuous slowing-down approximation is used for those electron interactions that result in small-energy losses. The extended transport correction is applied to the forward-peaked elasticmore » scattering cross section for electrons. A standard multigroup-Legendre treatment is used for the other coupled electron-photon cross sections. CEPXS extracts electron cross-section information from the DATAPAC data set and photon cross-section information from Biggs-Lighthill data. The model that is used for ionization/relaxation in CEPXS is essentially the same as that employed in ITS.« less

  9. Near threshold Λ(1115) photo production on a deuteron

    NASA Astrophysics Data System (ADS)

    Beckford, Brian; NKS2 Collaboration

    2014-09-01

    Experiments focused on the photo-production of K0 and Lambda in the threshold energy region were performed at Research Center for Electron Photon Science, Tohoku University (ELPH). We carried out the study using tagged photons at energies between 0.8--1.08 GeV incident on a liquid deuterium target. Measurements of the decay products from the produced strange particles were accomplished utilizing the upgraded Neutral Kaon Spectrometer (NKS2). We present momentum and angle dependent differential cross sections, integrated and total cross sections as well as recoil polarizations in this report. Recent theoretical predictions were compared with our experimental findings and are discussed. Experiments focused on the photo-production of K0 and Lambda in the threshold energy region were performed at Research Center for Electron Photon Science, Tohoku University (ELPH). We carried out the study using tagged photons at energies between 0.8--1.08 GeV incident on a liquid deuterium target. Measurements of the decay products from the produced strange particles were accomplished utilizing the upgraded Neutral Kaon Spectrometer (NKS2). We present momentum and angle dependent differential cross sections, integrated and total cross sections as well as recoil polarizations in this report. Recent theoretical predictions were compared with our experimental findings and are discussed. This work was supported by the JSPS KAKENHI Grant, 16GS0201 and 21002.

  10. Nanoimprint-Assisted Shear Exfoliation (NASE) for Producing Multilayer MoS2 Structures as Field-Effect Transistor Channel Arrays.

    PubMed

    Chen, Mikai; Nam, Hongsuk; Rokni, Hossein; Wi, Sungjin; Yoon, Jeong Seop; Chen, Pengyu; Kurabayashi, Katsuo; Lu, Wei; Liang, Xiaogan

    2015-09-22

    MoS2 and other semiconducting transition metal dichalcogenides (TMDCs) are of great interest due to their excellent physical properties and versatile chemistry. Although many recent research efforts have been directed to explore attractive properties associated with MoS2 monolayers, multilayer/few-layer MoS2 structures are indeed demanded by many practical scale-up device applications, because multilayer structures can provide sizable electronic/photonic state densities for driving upscalable electrical/optical signals. Currently there is a lack of processes capable of producing ordered, pristine multilayer structures of MoS2 (or other relevant TMDCs) with manufacturing-grade uniformity of thicknesses and electronic/photonic properties. In this article, we present a nanoimprint-based approach toward addressing this challenge. In this approach, termed as nanoimprint-assisted shear exfoliation (NASE), a prepatterned bulk MoS2 stamp is pressed into a polymeric fixing layer, and the imprinted MoS2 features are exfoliated along a shear direction. This shear exfoliation can significantly enhance the exfoliation efficiency and thickness uniformity of exfoliated flakes in comparison with previously reported exfoliation processes. Furthermore, we have preliminarily demonstrated the fabrication of multiple transistors and biosensors exhibiting excellent device-to-device performance consistency. Finally, we present a molecular dynamics modeling analysis of the scaling behavior of NASE. This work holds significant potential to leverage the superior properties of MoS2 and other emerging TMDCs for practical scale-up device applications. PMID:26302003

  11. Fabrication and design of metal nano-accordion structures using atomic layer deposition and interference lithography

    NASA Astrophysics Data System (ADS)

    Min, J.-H.; Bagal, A.; Mundy, J. Z.; Oldham, C. J.; Wu, B.-I.; Parsons, G. N.; Chang, C.-H.

    2016-02-01

    Metal nanostructures have attractive electrical and thermal properties as well as structural stability, and are important for applications in flexible conductors. In this study, we have developed a method to fabricate and control novel complex platinum nanostructures with accordion-like profile using atomic layer deposition on lithographically patterned polymer templates. The template removal process results in unique structural transformation of the nanostructure profile, which has been studied and modeled. Using different template duty cycles and aspect ratios, we have demonstrated a wide variety of cross-sectional profiles from wavy geometry to pipe array patterns. These complex thin metal nanostructures can find applications in flexible/stretchable electronics, photonics and nanofluidics.Metal nanostructures have attractive electrical and thermal properties as well as structural stability, and are important for applications in flexible conductors. In this study, we have developed a method to fabricate and control novel complex platinum nanostructures with accordion-like profile using atomic layer deposition on lithographically patterned polymer templates. The template removal process results in unique structural transformation of the nanostructure profile, which has been studied and modeled. Using different template duty cycles and aspect ratios, we have demonstrated a wide variety of cross-sectional profiles from wavy geometry to pipe array patterns. These complex thin metal nanostructures can find applications in flexible/stretchable electronics, photonics and nanofluidics. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr08566g

  12. Gauge-invariant dynamical quantities of QED with decomposed gauge potentials

    SciTech Connect

    Zhou Baohua; Huang Yongchang

    2011-09-15

    We discover an inner structure of the QED system; i.e., by decomposing the gauge potential into two orthogonal components, we obtain a new expansion of the Lagrangian for the electron-photon system, from which, we realize the orthogonal decomposition of the canonical momentum conjugate to the gauge potential with the canonical momentum's two components conjugate to the gauge potential's two components, respectively. Using the new expansion of Lagrangian and by the general method of field theory, we naturally derive the gauge invariant separation of the angular momentum of the electron-photon system from Noether theorem, which is the rational one and has the simplest form in mathematics, compared with the other four versions of the angular momentum separation available in literature. We show that it is only the longitudinal component of the gauge potential that is contained in the orbital angular momentum of the electron, as Chen et al. have said. A similar gauge invariant separation of the momentum is given. The decomposed canonical Hamiltonian is derived, from which we construct the gauge invariant energy operator of the electron moving in the external field generated by a proton [Phys. Rev. A 82, 012107 (2010)], where we show that the form of the kinetic energy containing the longitudinal part of the gauge potential is due to the intrinsic requirement of the gauge invariance. Our method provides a new perspective to look on the nucleon spin crisis and indicates that this problem can be solved strictly and systematically.

  13. Characterization of 2 MeV, 4 MeV, 6 MeV and 18 MeV buildup caps for use with a 0.6 cubic centimeter thimble ionization chamber

    SciTech Connect

    Salyer, R.L.; VanDenburg, J.W.; Prinja, A.K.; Kirby, T.; Busch, R.; Hong-Nian Jow

    1996-07-01

    The purpose of this research is to characterize existing 2 MeV, 4 MeV and 6 MeV buildup caps, and to determine if a buildup cap can be made for the 0.6 cm{sup 3} thimble ionization chamber that will accurately measure exposures in a high-energy photon radiation field. Two different radiation transport codes were used to computationally characterize existing 2 MeV, 4 MeV, and 6 MeV buildup caps for a 0.6 cm{sup 3} active volume thimble ionization chamber: ITS, The Integrated TIGER Series of Coupled Electron-Photon Monte Carlo Transport Codes; and CEPXS/ONEDANT, A One-Dimensional Coupled Electron-Photon Discrete Ordinates Code Package. These codes were also used to determine the design characteristics of a buildup cap for use in the 18 MeV photon beam produced by the 14 TW pulsed power HERMES-III electron accelerator. The maximum range of the secondary electron, the depth at which maximum dose occurs, and the point where dose and collision kerma are equal have been determined to establish the validity of electronic equilibrium. The ionization chamber with the appropriate buildup cap was then subjected to a 4 MeV and a 6 MeV bremmstrahlung radiation spectrum to determine the detector response.

  14. Charge separation and photovoltaic conversion in polymer composites with internal donor/acceptor heterojunctions

    SciTech Connect

    Yu, G.; Heeger, A.J.

    1995-10-01

    The photosensitivity of semiconducting polymers can be enhanced by blending donor and acceptor polymers to optimize photoinduced charge separation. We describe a novel phase-separated polymer blend (composite) made with poly[2-methoxy-5-(2{prime}-ethyl-hexyloxy)-1,4-phenylene vinylene], MEH-PPV, as donor and cyano-PPV, CN-PPV, as acceptor. The photoluminescence and electroluminescence of both component polymers are quenched in the blend, indicative of rapid and efficient separation of photogenerated electron-hole pairs with electrons on the acceptor and holes on the donor. Diodes made with such a composite semiconducting polymer as the photosensitive medium show promising photovoltaic characteristics with carrier collection efficiency of 5% electrons/photon and energy conversion efficiency of 0.9%, {similar_to}20 times larger than in diodes made with pure MEH-PPV and {similar_to}100 times larger than in diodes made with CN-PPV. The photosensitivity and the quantum yield increase with reverse bias voltage, to 0.3 A/W and 80% electrons/photon respectively at {minus}10 V, comparable to results obtained from photodiodes made with inorganic semiconductors. {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}.

  15. Kohn-Sham approach to quantum electrodynamical density-functional theory: Exact time-dependent effective potentials in real space.

    PubMed

    Flick, Johannes; Ruggenthaler, Michael; Appel, Heiko; Rubio, Angel

    2015-12-15

    The density-functional approach to quantum electrodynamics extends traditional density-functional theory and opens the possibility to describe electron-photon interactions in terms of effective Kohn-Sham potentials. In this work, we numerically construct the exact electron-photon Kohn-Sham potentials for a prototype system that consists of a trapped electron coupled to a quantized electromagnetic mode in an optical high-Q cavity. Although the effective current that acts on the photons is known explicitly, the exact effective potential that describes the forces exerted by the photons on the electrons is obtained from a fixed-point inversion scheme. This procedure allows us to uncover important beyond-mean-field features of the effective potential that mark the breakdown of classical light-matter interactions. We observe peak and step structures in the effective potentials, which can be attributed solely to the quantum nature of light; i.e., they are real-space signatures of the photons. Our findings show how the ubiquitous dipole interaction with a classical electromagnetic field has to be modified in real space to take the quantum nature of the electromagnetic field fully into account. PMID:26627715

  16. Quantitative evaluation of patient setup uncertainty of stereotactic radiotherapy with the frameless 6D ExacTrac system using statistical modeling.

    PubMed

    Keeling, Vance; Hossain, Sabbir; Jin, Hosang; Algan, Ozer; Ahmad, Salahuddin; Ali, Imad

    2016-01-01

    The purpose of this study is to evaluate patient setup accuracy and quantify indi-vidual and cumulative positioning uncertainties associated with different hardware and software components of the stereotactic radiotherapy (SRS/SRT) with the frameless 6D ExacTrac system. A statistical model is used to evaluate positioning uncertainties of the different components of SRS/SRT treatment with the Brainlab 6D ExacTrac system using the positioning shifts of 35 patients having cranial lesions. All these patients are immobilized with rigid head-and-neck masks, simu-lated with Brainlab localizer and planned with iPlan treatment planning system. Stereoscopic X-ray images (XC) are acquired and registered to corresponding digitally reconstructed radiographs using bony-anatomy matching to calculate 6D translational and rotational shifts. When the shifts are within tolerance (0.7 mm and 1°), treatment is initiated. Otherwise corrections are applied and additional X-rays (XV) are acquired to verify that patient position is within tolerance. The uncertain-ties from the mask, localizer, IR -frame, X-ray imaging, MV, and kV isocentricity are quantified individually. Mask uncertainty (translational: lateral, longitudinal, vertical; rotational: pitch, roll, yaw) is the largest and varies with patients in the range (-2.07-3.71 mm, -5.82-5.62 mm, -5.84-3.61 mm; -2.10-2.40°, -2.23-2.60°, and -2.7-3.00°) obtained from mean of XC shifts for each patient. Setup uncer-tainty in IR positioning (0.88, 2.12, 1.40 mm, and 0.64°, 0.83°, 0.96°) is extracted from standard deviation of XC. Systematic uncertainties of the frame (0.18, 0.25, -1.27mm, -0.32°, 0.18°, and 0.47°) and localizer (-0.03, -0.01, 0.03mm, and -0.03°, 0.00°, -0.01°) are extracted from means of all XV setups and mean of all XC distributions, respectively. Uncertainties in isocentricity of the MV radiotherapy machine are (0.27, 0.24, 0.34 mm) and kV imager (0.15, -0.4, 0.21 mm). A statisti-cal model is developed to

  17. SU-E-J-139: One Institution’s Experience with Surface Imaging in Proton Therapy

    SciTech Connect

    Zhao, L; Singh, H; Zheng, Y

    2015-06-15

    Purpose: X-ray system is commonly used for IGRT in proton therapy, however image acquisition not only increases treatment time but also adds imaging dose. We studied a 3D surface camera system (AlignRT) performance for proton therapy. Methods: System accuracy was evaluated with rigid phantom under two different camera location configurations. For initial clinical applications, post mastectomy chest wall and partial breast treatments were studied. X-ray alignment was used as our ground truth. Our studies included: 1) comparison of daily patient setup shifts between X-ray alignment and SI calculation; 2) interfractional breast surface position variation when aligning to bony landmark on X-ray; 3) absolute positioning using planning CT DICOM data; 4) shifts for multi-isocenter treatment plan; 5) couch isocentric rotation accuracy. Results: Camera locations affected the system performance. After camera relocation, the accuracy of the system for the rigid phantom was within 1 mm (fixed couch), and 1.5 mm (isocentric rotation). For intrafractional patient positioning, X-ray and AlignRT shifts were highly correlated (r=0.99), with the largest difference (mean ± SD) in the longitudinal direction (2.14 ± 1.02 mm). For interfractional breast surface variation and absolute positioning, there were still larger disagreements between the two modalities due to different focus on anatomical landmarks, and 95% of the data lie within 5mm with some outliers at 7 mm–9 mm. For multi-isocenter shifts, the difference was 1 ± 0.56 mm over an 11 cm shift in longitudinal direction. For couch rotation study, the differences was 1.36 ± 1.0 mm in vertical direction, 3.04 ± 2.11 mm in longitudinal direction, and 2.10 ± 1.66 mm in lateral direction, with all rotation differences < 1.5 degree. Conclusion: Surface imaging is promising for intrafractional treatment application in proton therapy to reduce X-ray frequency. However the interfractional discrepancy between the X-ray and SI

  18. SU-E-J-213: Imaging and Treatment Isocenter Verification of a Gantry Mounted Proton Therapy System

    SciTech Connect

    Price, S; Goddu, S; Rankine, L; Klein, E

    2014-06-01

    Purpose: The Mevion proton therapy machine is the first to feature a gantry mounted sychro-cyclotron. In addition, the system utilizes a 6D motion couch and kV imaging for precise proton therapy. To quantify coincidence between these systems, isocentricity tests were performed based on kV imaging alignment using radiochromic film. Methods: The 100 ton gantry and 6D robotic couch can rotate 190° around isocenter to provide necessary beam angles for treatment. The kV sources and detector panels are deployed as needed to acquire orthogonal portals. Gantry and couch mechanical isocenter were tested using star-shots and radiochromic-film (RCF). Using kV imaging, the star-shot phantom was aligned to an embedded fiducial and the isocenter was marked on RCF with a pinprick. The couch and gantry stars were performed by irradiating films at every 45° and 30°, respectively. A proton beam with a range and modulation-width of 18 cm was used. A Winston-Lutz test was also performed at the same gantry and couch rotations using a custom jig holding RCF and a tungsten ball placed at isocenter. A 2 cm diameter circular aperture was used for the irradiation. Results: The couch star-shot indicated a minimum tangent circle of 0.6 mm, with a 0.9 mm offset from the manually marked isocenter. The gantry star-shot showed a 0.6 mm minimum tangent circle with a 0.5 mm offset from the pinprick. The Winston Lutz test performed for gantry rotation showed a maximum deviation from center of 0.5 mm. Conclusion: Based on star-shots and Winston-Lutz tests, the proton gantry and 6D couch isocentricity are within 1 mm. In this study, we have shown that the methods commonly utilized for Linac characterization can be applied to proton therapy. This revolutionary proton therapy system possesses excellent agreement between the mechanical and radiation isocenter, providing highly precise treatment.

  19. Fast transit portal dosimetry using density-scaled layer modeling of aSi-based electronic portal imaging device and Monte Carlo method

    SciTech Connect

    Jung, Jae Won; Kim, Jong Oh; Yeo, Inhwan Jason; Cho, Young-Bin; Kim, Sun Mo; DiBiase, Steven

    2012-12-15

    Purpose: Fast and accurate transit portal dosimetry was investigated by developing a density-scaled layer model of electronic portal imaging device (EPID) and applying it to a clinical environment. Methods: The model was developed for fast Monte Carlo dose calculation. The model was validated through comparison with measurements of dose on EPID using first open beams of varying field sizes under a 20-cm-thick flat phantom. After this basic validation, the model was further tested by applying it to transit dosimetry and dose reconstruction that employed our predetermined dose-response-based algorithm developed earlier. The application employed clinical intensity-modulated beams irradiated on a Rando phantom. The clinical beams were obtained through planning on pelvic regions of the Rando phantom simulating prostate and large pelvis intensity modulated radiation therapy. To enhance agreement between calculations and measurements of dose near penumbral regions, convolution conversion of acquired EPID images was alternatively used. In addition, thickness-dependent image-to-dose calibration factors were generated through measurements of image and calculations of dose in EPID through flat phantoms of various thicknesses. The factors were used to convert acquired images in EPID into dose. Results: For open beam measurements, the model showed agreement with measurements in dose difference better than 2% across open fields. For tests with a Rando phantom, the transit dosimetry measurements were compared with forwardly calculated doses in EPID showing gamma pass rates between 90.8% and 98.8% given 4.5 mm distance-to-agreement (DTA) and 3% dose difference (DD) for all individual beams tried in this study. The reconstructed dose in the phantom was compared with forwardly calculated doses showing pass rates between 93.3% and 100% in isocentric perpendicular planes to the beam direction given 3 mm DTA and 3% DD for all beams. On isocentric axial planes, the pass rates varied

  20. SU-E-T-226: Junction Free Craniospinal Irradiation in Linear Accelerator Using Volumetric Modulated Arc Therapy : A Novel Technique Using Dose Tapering

    SciTech Connect

    Sarkar, B; Roy, S; Paul, S; Munshi, A; Roy, Shilpi; Jassal, K; Ganesh, T; Mohanti, BK

    2014-06-01

    Purpose: Spatially separated fields are required for craniospinal irradiation due to field size limitation in linear accelerator. Field junction shits are conventionally done to avoid hot or cold spots. Our study was aimed to demonstrate the feasibility of junction free irradiation plan of craniospinal irradiation (CSI) for Meduloblastoma cases treated in linear accelerator using Volumetric modulated arc therapy (VMAT) technique. Methods: VMAT was planned using multiple isocenters in Monaco V 3.3.0 and delivered in Elekta Synergy linear accelerator. A full arc brain and 40° posterior arc spine fields were planned using two isocentre for short (<1.3 meter height ) and 3 isocentres for taller patients. Unrestricted jaw movement was used in superior-inferior direction. Prescribed dose to PTV was achieved by partial contribution from adjacent beams. A very low dose gradient was generated to taper the isodoses over a long length (>10 cm) at the conventional field junction. Results: In this primary study five patients were planned and three patients were delivered using this novel technique. As the dose contribution from the adjacent beams were varied (gradient) to create a complete dose distribution, therefore there is no specific junction exists in the plan. The junction were extended from 10–14 cm depending on treatment plan. Dose gradient were 9.6±2.3% per cm for brain and 7.9±1.7 % per cm for spine field respectively. Dose delivery error due to positional inaccuracy was calculated for brain and spine field for ±1mm, ±2mm, ±3mm and ±5 mm were 1%–0.8%, 2%–1.6%, 2.8%–2.4% and 4.3%–4% respectively. Conclusion: Dose tapering in junction free CSI do not require a junction shift. Therefore daily imaging for all the field is also not essential. Due to inverse planning dose to organ at risk like thyroid kidney, heart and testis can be reduced significantly. VMAT gives a quicker delivery than Step and shoot or dynamic IMRT.

  1. SU-E-T-539: Maximum Energy of Helium and Carbon Ions Clinically Needed for Spine, Lung, Prostate and Pancreas Cancer

    SciTech Connect

    Pompos, A; Choy, H; Jia, X; Jiang, S; Timmerman, R

    2015-06-15

    Purpose: Maximum available kinetic energy of accelerated heavy ions is a critical parameter to consider during the establishment of a heavy ion therapy center. It dictates the maximum range in tissue and determines the size and cost of ion gantry. We have started planning our heavy ion therapy center and we report on the needed ion range. Methods: We analyzed 50 of random SBRT-spine, SBRT- lung, prostate and pancreatic cancer patients from our photon clinic. In the isocentric axial CT cut we recorded the maximum water equivalent depth (WED4Field) of PTV’s most distal edge in four cardinal directions and also in a beam direction that required the largest penetration, WEDGantry. These depths were then used to calculate the percentage of our patients we would be able to treat as a function of available maximum carbon and helium beam energy. Based on the Anterior-Posterior WED for lung patients and the maximum available ion energy we estimated the largest possible non-coplanar beam entry angle φ (deviation from vertical) in the isocentric vertical sagittal plane. Results: We found that if 430MeV/u C-12, equivalently 220MeV/u He-4, beams are available, more than 96% (98%) of all patients can be treated without any gantry restrictions (in cardinals angles only) respectively. If the energy is reduced to 400MeV/u C-12, equivalently 205MeV/u He-4, the above fractions reduce to 80% (87%) for prostate and 88% (97%) for other sites. This 7% energy decrease translates to almost 5% gantry size and cost decrease for both ions. These energy limits in combination with the WED in the AP direction for lung patients resulted in average non-coplanar angles of φ430MeV/u = 68°±8° and φ400MeV/u = 65°±10° if nozzle clearance permits them. Conclusion: We found that the two worldwide most common maximum carbon beam energies will treat above 80% of all our patients.

  2. SU-E-T-80: Comparison of Fluence-Based RapidArc QAs Using EPID and MapCHECK 2

    SciTech Connect

    Jin, H; Jesseph, F; Ahmad, S

    2014-06-01

    Purpose: To compare the Varian aS-1000 EPID imager to the isocentrically mounted MapCHECK 2 diode array for RapidArc QAs as a function of photon beam energy. Methods: A Varian TrueBeam STx with an aS-1000 digital imaging panel was used to acquire RapidArc QA images for 13 patient plans; each plan QA was performed at 6, 8, 10 and 15MV energies. The Portal Dose Image Prediction algorithm in the Varian Eclipse treatment planning system (TPS) was used to create the comparison image for the EPID acquisition. A Sun Nuclear MapCHECK 2 diode array on an isocentric mounting fixture with 5 cm water-equivalent buildup was also used for the RapidArc QAs. A composite dose plane was taken from the Eclipse TPS for comparison to the MapCHECK 2 measurements. A gamma test was implemented in the Sun Nuclear Patient software with 10% threshold and absolute comparison for both QA methods. The two-tailed paired t-test was employed to analyze the statistical significance between two methods at the 95% confidence level. Results: The average gamma passing rates were greater than 95% at 3%/3mm using both methods for all four energies. The average passing rates were within 2.5% and 1.1% of each other when analyzed at 2%/2mm and 3%/3mm conditions, respectively. The EPID passing rates were somewhat better than the MapCHECK 2 when analyzed at 1%/1mm condition; this difference decreased with increasing energy (9.1% at 6MV to 2.7% at 15MV). The differences were not statistically significant for all criteria and energies (p-value ã 0.05). Conclusion: EPID-based RapidArc QA results are comparable to MapCHECK 2 when using 3%/3mm criteria at all four energies. EPID-based QA shows potential for being the superior device under strict gamma criteria.

  3. Monte Carlo estimation of photoneutrons contamination from high-energy X-ray medical accelerators in treatment room and maze: a simplified model.

    PubMed

    Zabihzadeh, Mansour; Ay, Mohammad Reza; Allahverdi, Mahmoud; Mesbahi, Asghar; Mahdavi, Seyed Rabee; Shahriari, Majid

    2009-07-01

    Despite all advantages associated with high-energy radiotherapy to improve therapeutic gain, the production of photoneutron via interaction of high-energy photons with high atomic number (Z) materials increases undesired dose to the patient and staff. Owing to the limitation and complication of experimental neutron dosimetry in mixed beam environment, including photon and neutron, the Monte Carlo (MC) simulation is a gold standard method for calculation of photoneutron contaminations. On the other hand, the complexity of treatment head makes the MC simulation more difficult and time-consuming. In this study, the possibility of using a simplified MC model for the simulation of treatment head has been investigated using MCNP4C general purpose MC code. As a part of comparative assessment strategy, the fluence, average energy and dose equivalent of photoneutrons were estimated and compared with other studies for several fields and energies at different points in treatment room and maze. The mean energy of photoneutrons was 0.17, 0.19 and 0.2 MeV at the patient plan for 10, 15 and 18 MeV, respectively. The calculated values differed, respectively, by a factor of 1.4, 0.7 and 0.61 compared with the reported measured data for 10, 15 and 18 MeV. Our simulation results in the maze showed that the neutron dose equivalent is attenuated by a factor of 10 for every 4.6 m of maze length while the related factor from Kersey analytical method is 5 m. The neutron dose equivalent was 4.1 mSv Gy(-1) at the isocentre and decreased to 0.79 mSv Gy(-1) at a distance of 100 cm away from the isocentre for 40 x 40 cm(2). There is good agreement between the data calculated using simplified model in this study and measurements. Considering the reported high uncertainties (up to 50%) in experimental neutron dosimetry, it can be concluded that the simplified model can be used as a useful tool for estimation of photoneutron contamination associated with high-energy photon radiotherapy. PMID

  4. Portal dosimetry for VMAT using integrated images obtained during treatment

    SciTech Connect

    Bedford, James L. Hanson, Ian M.; Hansen, Vibeke Nordmark

    2014-02-15

    Purpose: Portal dosimetry provides an accurate and convenient means of verifying dose delivered to the patient. A simple method for carrying out portal dosimetry for volumetric modulated arc therapy (VMAT) is described, together with phantom measurements demonstrating the validity of the approach. Methods: Portal images were predicted by projecting dose in the isocentric plane through to the portal image plane, with exponential attenuation and convolution with a double-Gaussian scatter function. Appropriate parameters for the projection were selected by fitting the calculation model to portal images measured on an iViewGT portal imager (Elekta AB, Stockholm, Sweden) for a variety of phantom thicknesses and field sizes. This model was then used to predict the portal image resulting from each control point of a VMAT arc. Finally, all these control point images were summed to predict the overall integrated portal image for the whole arc. The calculated and measured integrated portal images were compared for three lung and three esophagus plans delivered to a thorax phantom, and three prostate plans delivered to a homogeneous phantom, using a gamma index for 3% and 3 mm. A 0.6 cm{sup 3} ionization chamber was used to verify the planned isocentric dose. The sensitivity of this method to errors in monitor units, field shaping, gantry angle, and phantom position was also evaluated by means of computer simulations. Results: The calculation model for portal dose prediction was able to accurately compute the portal images due to simple square fields delivered to solid water phantoms. The integrated images of VMAT treatments delivered to phantoms were also correctly predicted by the method. The proportion of the images with a gamma index of less than unity was 93.7% ± 3.0% (1SD) and the difference between isocenter dose calculated by the planning system and measured by the ionization chamber was 0.8% ± 1.0%. The method was highly sensitive to errors in monitor units and

  5. Improved volumetric imaging in tomosynthesis using combined multiaxial sweeps.

    PubMed

    Gersh, Jacob A; Wiant, David B; Best, Ryan C M; Bennett, Marcus C; Munley, Michael T; King, June D; McKee, Mahta M; Baydush, Alan H

    2010-01-01

    This study explores the volumetric reconstruction fidelity attainable using tomosynthesis with a kV imaging system which has a unique ability to rotate isocentrically and with multiple degrees of mechanical freedom. More specifically, we seek to investigate volumetric reconstructions by combining multiple limited-angle rotational image acquisition sweeps. By comparing these reconstructed images with those of a CBCT reconstruction, we can gauge the volumetric fidelity of the reconstructions. In surgical situations, the described tomosynthesis-based system could provide high-quality volumetric imaging without requiring patient motion, even with rotational limitations present. Projections were acquired using the Digital Integrated Brachytherapy Unit, or IBU-D. A phantom was used which contained several spherical objects of varying contrast. Using image projections acquired during isocentric sweeps around the phantom, reconstructions were performed by filtered backprojection. For each image acquisition sweep configuration, a contrasting sphere is analyzed using two metrics and compared to a gold standard CBCT reconstruction. Since the intersection of a reconstructed sphere and an imaging plane is ideally a circle with an eccentricity of zero, the first metric presented compares the effective eccentricity of intersections of reconstructed volumes and imaging planes. As another metric of volumetric reconstruction fidelity, the volume of one of the contrasting spheres was determined using manual contouring. By comparing these manually delineated volumes with a CBCT reconstruction, we can gauge the volumetric fidelity of reconstructions. The configuration which yielded the highest overall volumetric reconstruction fidelity, as determined by effective eccentricities and volumetric contouring, consisted of two orthogonally-offset 60° L-arm sweeps and a single C-arm sweep which shared a pivot point with one the L-arm sweeps. When compared to a similar configuration that

  6. Locoregional Treatment for Breast Carcinoma After Hodgkin's Lymphoma: The Breast Conservation Option

    SciTech Connect

    Haberer, Sophie; Belin, Lisa; Le Scodan, Romuald; Kirova, Youlia M.; Savignoni, Alexia; Stevens, Denise; Moisson, Patricia; Decaudin, Didier; Pierga, Jean-Yves; Reyal, Fabien; Campana, Francois; Fourquet, Alain; Bollet, Marc A.

    2012-02-01

    Purpose: To report clinical and pathologic characteristics and outcome of breast cancer (BC) after irradiation for Hodgkin's lymphoma (HL) in women treated at the Institut Curie, with a special focus on the breast-conserving option. Methods and Materials: Medical records of 72 women who developed either ductal carcinoma in situ or Stage I-III invasive carcinoma of the breast after HL between 1978 and 2009 were retrospectively reviewed. Results: Median age at HL diagnosis was 23 years (range, 14-53 years). Median total dose received by the mediastinum was 40 Gy, mostly by a mantle-field technique. Breast cancers occurred after a median interval of 21 years (range, 5-40 years). Ductal invasive carcinoma and ductal carcinoma in situ represented, respectively, 51 cases (71%) and 14 cases (19%). Invasive BCs consisted of 47 cT0-2 tumors (82%), 5 cN1-3 tumors (9%), and 20 Grade 3 tumors (35%). Locoregional treatment for BCs consisted of mastectomy with (3) or without (36) radiotherapy in 39 patients and lumpectomy with (30) or without (2) adjuvant radiotherapy in 32 patients. The isocentric lateral decubitus radiation technique was used in 17 patients after breast-conserving surgery (57%). With a median follow-up of 7 years, 5-year overall survival rate and locoregional control rate were, respectively, 74.5% (95% confidence interval [CI], 64-88%) and 82% (95% CI, 72-93%) for invasive carcinoma and 100% (95% CI, 100 -100%) and 92% (95% CI, 79-100%) for in situ carcinoma. In patients with invasive tumors, the 5-year distant disease-free survival rate was 79% (95% CI, 69-91%), and 13 patients died of progressive BC. Contralateral BC was diagnosed in 10 patients (14%). Conclusions: Breast-conserving treatment can be an option for BCs that occur after HL, despite prior thoracic irradiation. It should consist of lumpectomy and adjuvant breast radiotherapy with use of adequate techniques, such as the lateral decubitus isocentric position, to protect the underlying heart and

  7. Optimal technique of linear accelerator-based stereotactic radiosurgery for tumors adjacent to brainstem.

    PubMed

    Chang, Chiou-Shiung; Hwang, Jing-Min; Tai, Po-An; Chang, You-Kang; Wang, Yu-Nong; Shih, Rompin; Chuang, Keh-Shih

    2016-01-01

    Stereotactic radiosurgery (SRS) is a well-established technique that is replacing whole-brain irradiation in the treatment of intracranial lesions, which leads to better preservation of brain functions, and therefore a better quality of life for the patient. There are several available forms of linear accelerator (LINAC)-based SRS, and the goal of the present study is to identify which of these techniques is best (as evaluated by dosimetric outcomes statistically) when the target is located adjacent to brainstem. We collected the records of 17 patients with lesions close to the brainstem who had previously been treated with single-fraction radiosurgery. In all, 5 different lesion catalogs were collected, and the patients were divided into 2 distance groups-1 consisting of 7 patients with a target-to-brainstem distance of less than 0.5cm, and the other of 10 patients with a target-to-brainstem distance of ≥ 0.5 and < 1cm. Comparison was then made among the following 3 types of LINAC-based radiosurgery: dynamic conformal arcs (DCA), intensity-modulated radiosurgery (IMRS), and volumetric modulated arc radiotherapy (VMAT). All techniques included multiple noncoplanar beams or arcs with or without intensity-modulated delivery. The volume of gross tumor volume (GTV) ranged from 0.2cm(3) to 21.9cm(3). Regarding the dose homogeneity index (HIICRU) and conformity index (CIICRU) were without significant difference between techniques statistically. However, the average CIICRU = 1.09 ± 0.56 achieved by VMAT was the best of the 3 techniques. Moreover, notable improvement in gradient index (GI) was observed when VMAT was used (0.74 ± 0.13), and this result was significantly better than those achieved by the 2 other techniques (p < 0.05). For V4Gy of brainstem, both VMAT (2.5%) and IMRS (2.7%) were significantly lower than DCA (4.9%), both at the p < 0.05 level. Regarding V2Gy of normal brain, VMAT plans had attained 6.4 ± 5%; this was significantly better (p < 0.05) than

  8. A technology platform for translational research on laser driven particle accelerators for radiotherapy

    NASA Astrophysics Data System (ADS)

    Enghardt, W.; Bussmann, M.; Cowan, T.; Fiedler, F.; Kaluza, M.; Pawelke, J.; Schramm, U.; Sauerbrey, R.; Tünnermann, A.; Baumann, M.

    2011-05-01

    It is widely accepted that proton or light ion beams may have a high potential for improving cancer cure by means of radiation therapy. However, at present the large dimensions of electromagnetic accelerators prevent particle therapy from being clinically introduced on a broad scale. Therefore, several technological approaches among them laser driven particle acceleration are under investigation. Parallel to the development of suitable high intensity lasers, research is necessary to transfer laser accelerated particle beams to radiotherapy, since the relevant parameters of laser driven particle beams dramatically differ from those of beams delivered by conventional accelerators: The duty cycle is low, whereas the number of particles and thus the dose rate per pulse are high. Laser accelerated particle beams show a broad energy spectrum and substantial intensity fluctuations from pulse to pulse. These properties may influence the biological efficiency and they require completely new techniques of beam delivery and quality assurance. For this translational research a new facility is currently constructed on the campus of the university hospital Dresden. It will be connected to the department of radiooncology and host a petawatt laser system delivering an experimental proton beam and a conventional therapeutic proton cyclotron. The cyclotron beam will be delivered on the one hand to an isocentric gantry for patient treatments and on the other hand to an experimental irradiation site. This way the conventional accelerator will deliver a reference beam for all steps of developing the laser based technology towards clinical applicability.

  9. Field size dependent mapping of medical linear accelerator radiation leakage

    NASA Astrophysics Data System (ADS)

    Vũ Bezin, Jérémi; Veres, Attila; Lefkopoulos, Dimitri; Chavaudra, Jean; Deutsch, Eric; de Vathaire, Florent; Diallo, Ibrahima

    2015-03-01

    The purpose of this study was to investigate the suitability of a graphics library based model for the assessment of linear accelerator radiation leakage. Transmission through the shielding elements was evaluated using the build-up factor corrected exponential attenuation law and the contribution from the electron guide was estimated using the approximation of a linear isotropic radioactive source. Model parameters were estimated by a fitting series of thermoluminescent dosimeter leakage measurements, achieved up to 100 cm from the beam central axis along three directions. The distribution of leakage data at the patient plane reflected the architecture of the shielding elements. Thus, the maximum leakage dose was found under the collimator when only one jaw shielded the primary beam and was about 0.08% of the dose at isocentre. Overall, we observe that the main contributor to leakage dose according to our model was the electron beam guide. Concerning the discrepancies between the measurements used to calibrate the model and the calculations from the model, the average difference was about 7%. Finally, graphics library modelling is a readily and suitable way to estimate leakage dose distribution on a personal computer. Such data could be useful for dosimetric evaluations in late effect studies.

  10. Status of the Proton Therapy Project at IUCF and the Midwest Proton Radiotherapy Institute

    SciTech Connect

    Klein, Susan B.

    2003-08-26

    The first proton therapy patient was successfully treated for astrocytoma using a modified nuclear experimentation beam line and in-house treatment planning in 1993. In 1998, IUCF constructed an eye treatment clinic, and conducted a phase III clinical trial investigating proton radiation treatment of AMD. Treatment was planned using Eyeplan modified to match the IUCF beam characteristics. MPRI was conceptualized in 1996 by a consortium of physicians and physicists. Reconfiguration began in 2000; construction of the achromatic trunk line began in 2001, followed by manufacture of 4 energy selection lines and two fixed horizontal beam treatment lines. Two isocentric, rotational gantries will be installed following completion of the horizontal beam lines. A fifth line will supply the full-time radiation effects research station. Standard proton delivery out of the main stage is specified at 500 nA of 205 MeV. Clinic construction began in April, 2002 and will be completed by mid-December. Design, construction and operation of these proton facilities have been accomplished by the proton therapy group at IUCF.

  11. Compact multileaf collimator for conformal and intensity modulated fast neutron therapy: electromechanical design and validation.

    PubMed

    Farr, J B; Maughan, R L; Yudelev, M; Blosser, E; Brandon, J; Horste, T; Forman, J D

    2006-09-01

    The electromechanical properties of a 120-leaf, high-resolution, computer-controlled, fast neutron multileaf collimator (MLC) are presented. The MLC replaces an aging, manually operated multirod collimator. The MLC leaves project 5 mm in the isocentric plane perpendicular to the beam axis. A taper is included on the leaves matching beam divergence along one axis. The 5-mm leaf projection width is chosen to give high-resolution conformality across the entire field. The maximum field size provided is 30 x 30 cm2. To reduce the interleaf transmission a 0.254-mm blocking step is included. End-leaf steps totaling 0.762 mm are also provided allowing opposing leaves to close off within the primary radiation beam. The neutron MLC also includes individual 45 degrees and 60 degrees automated universal tungsten wedges. The automated high-resolution neutron collimation provides an increase in patient throughput capacity, enables a new modality, intensity modulated neutron therapy, and limits occupational radiation exposure by providing remote operation from a shielded console area. PMID:17022226

  12. Development and Clinical Implementation of a Universal Bolus to Maintain Spot Size During Delivery of Base of Skull Pencil Beam Scanning Proton Therapy

    SciTech Connect

    Both, Stefan; Shen, Jiajian; Kirk, Maura; Lin, Liyong; Tang, Shikui; Alonso-Basanta, Michelle; Lustig, Robert; Lin, Haibo; Deville, Curtiland; Hill-Kayser, Christine; Tochner, Zelig; McDonough, James

    2014-09-01

    Purpose: To report on a universal bolus (UB) designed to replace the range shifter (RS); the UB allows the treatment of shallow tumors while keeping the pencil beam scanning (PBS) spot size small. Methods and Materials: Ten patients with brain cancers treated from 2010 to 2011 were planned using the PBS technique with bolus and the RS. In-air spot sizes of the pencil beam were measured and compared for 4 conditions (open field, with RS, and with UB at 2- and 8-cm air gap) in isocentric geometry. The UB was applied in our clinic to treat brain tumors, and the plans with UB were compared with the plans with RS. Results: A UB of 5.5 cm water equivalent thickness was found to meet the needs of the majority of patients. By using the UB, the PBS spot sizes are similar with the open beam (P>.1). The heterogeneity index was found to be approximately 10% lower for the UB plans than for the RS plans. The coverage for plans with UB is more conformal than for plans with RS; the largest increase in sparing is usually for peripheral organs at risk. Conclusions: The integrity of the physical properties of the PBS beam can be maintained using a UB that allows for highly conformal PBS treatment design, even in a simple geometry of the fixed beam line when noncoplanar beams are used.

  13. Dosimetrical evaluation of Leksell Gamma Knife 4C radiosurgery unit

    NASA Astrophysics Data System (ADS)

    Sajeev, Thomas; Mustafa, Mohamed M.; Supe, Sanjay S.

    2011-01-01

    A number of experiments was performed using standard protocols, in order to evaluate the dosimetric accuracy of Leksell Gamma Knife 4C unit. Verification of the beam alignment has been performed for all collimators using solid plastic head phantom and Gafchromic™ type MD-55 films. The study showed a good agreement of Leksell Gammaplan calculated dose profiles with experimentally determined profiles in all three axes. Isocentric accuracy is verified using a specially machined cylindrical aluminium film holder tool made with very narrow geometric tolerances aligned between trunnions of 4 mm collimator. Considering all uncertainties in all three dimensions, the estimated accuracy of the unit was 0.1 mm. Dose rate at the centre point of the unit has been determined according to the IAEA, TRS-398 protocol, using Unidose-E (PTW-Freiburg, Germany) with a 0.125 cc ion chamber, over a period of 6 years. The study showed that the Leksell Gamma Knife 4C unit is excellent radiosurgical equipment with high accuracy and precision, which makes it possible to deliver larger doses of radiation, within the limits defined by national and international guidelines, applicable for stereotactic radiosurgery procedures.

  14. Modelling of electron contamination in clinical photon beams for Monte Carlo dose calculation

    NASA Astrophysics Data System (ADS)

    Yang, J.; Li, J. S.; Qin, L.; Xiong, W.; Ma, C.-M.

    2004-06-01

    The purpose of this work is to model electron contamination in clinical photon beams and to commission the source model using measured data for Monte Carlo treatment planning. In this work, a planar source is used to represent the contaminant electrons at a plane above the upper jaws. The source size depends on the dimensions of the field size at the isocentre. The energy spectra of the contaminant electrons are predetermined using Monte Carlo simulations for photon beams from different clinical accelerators. A 'random creep' method is employed to derive the weight of the electron contamination source by matching Monte Carlo calculated monoenergetic photon and electron percent depth-dose (PDD) curves with measured PDD curves. We have integrated this electron contamination source into a previously developed multiple source model and validated the model for photon beams from Siemens PRIMUS accelerators. The EGS4 based Monte Carlo user code BEAM and MCSIM were used for linac head simulation and dose calculation. The Monte Carlo calculated dose distributions were compared with measured data. Our results showed good agreement (less than 2% or 2 mm) for 6, 10 and 18 MV photon beams.

  15. An ion-optical design study of a carbon-ion rotating gantry with a superconducting final bending magnet

    NASA Astrophysics Data System (ADS)

    Bokor, J.; Pavlovič, M.

    2016-03-01

    Ion-optical designs of an isocentric ion gantry with a compact curved superconducting final bending magnet are presented. The gantry is designed for transporting carbon-therapy beams with nominal kinetic energy of 400 MeV/u, which corresponds to the penetration range of C6+ beam in water of about 28 cm. In contrast to other existing designs, we present a "hybrid" beam transport system containing a single superconducting element - the last bending magnet. All other elements are based on conventional warm technology. Ion-optical properties of such a hybrid system are investigated in case of transporting non-symmetric (i.e. different emittance patterns in the horizontal and vertical plane) beams. Different conditions for transporting the non-symmetric beams are analyzed aiming at finding the optimal, i.e. the most compact, gantry version. The final gantry layout is presented including a 2D parallel scanning. The ion-optical and scanning properties of the final gantry design are described, discussed and illustrated by computer simulations performed by WinAGILE.

  16. Characterization of electron contamination in megavoltage photon beams

    SciTech Connect

    Medina, Antonio Lopez; Teijeiro, Antonio; Garcia, Juan; Esperon, Jorge; Terron, J. Antonio; Ruiz, Diego P.; Carrion, Maria C.

    2005-05-01

    The purpose of the present study is to characterize electron contamination in photon beams in different clinical situations. Variations with field size, beam modifier (tray, shaping block) and source-surface distance (SSD) were studied. Percentage depth dose measurements with and without a purging magnet and replacing the air by helium were performed to identify the two electron sources that are clearly differentiated: air and treatment head. Previous analytical methods were used to fit the measured data, exploring the validity of these models. Electrons generated in the treatment head are more energetic and more important for larger field sizes, shorter SSD, and greater depths. This difference is much more noticeable for the 18 MV beam than for the 6 MV beam. If a tray is used as beam modifier, electron contamination increases, but the energy of these electrons is similar to that of electrons coming from the treatment head. Electron contamination could be fitted to a modified exponential curve. For machine modeling in a treatment planning system, setting SSD at 90 cm for input data could reduce errors for most isocentric treatments, because they will be delivered for SSD ranging from 80 to 100 cm. For very small field sizes, air-generated electrons must be considered independently, because of their different energetic spectrum and dosimetric influence.

  17. Geant4 studies of the CNAO facility system for hadrontherapy treatment of uveal melanomas

    NASA Astrophysics Data System (ADS)

    Rimoldi, A.; Piersimoni, P.; Pirola, M.; Riccardi, C.

    2014-06-01

    The Italian National Centre of Hadrontherapy for Cancer Treatment (CNAO -Centro Nazionale di Adroterapia Oncologica) in Pavia, Italy, has started the treatment of selected cancers with the first patients in late 2011. In the coming months at CNAO plans are to activate a new dedicated treatment line for irradiation of uveal melanomas using the available active beam scan. The beam characteristics and the experimental setup should be tuned in order to reach the necessary precision required for such treatments. Collaboration between CNAO foundation, University of Pavia and INFN has started in 2011 to study the feasibility of these specialised treatments by implementing a MC simulation of the transport beam line and comparing the obtained simulation results with measurements at CNAO. The goal is to optimise an eye-dedicated transport beam line and to find the best conditions for ocular melanoma irradiations. This paper describes the Geant4 toolkit simulation of the CNAO setup as well as a modelised human eye with a tumour inside. The Geant4 application could be also used to test possible treatment planning systems. Simulation results illustrate the possibility to adapt the CNAO standard transport beam line by optimising the position of the isocentre and the addition of some passive elements to better shape the beam for this dedicated study.

  18. Numerical study of remote detection outside the magnet with travelling wave Magnetic Resonance Imaging at 3T

    NASA Astrophysics Data System (ADS)

    López, M.; Vázquez, F.; Solís-Nájera, S.; Rodriguez, A. O.

    2015-01-01

    The use of the travelling wave approach for high magnetic field magnetic resonance imaging has been used recently with very promising results. This approach offer images one with greater field-of-view and a reasonable signal-to-noise ratio using a circular waveguide. This scheme has been proved to be successful at 7 T and 9.4 T with whole-body imager. Images have also been acquired with clinical magnetic resonance imaging systems whose resonant frequencies were 64 MHz and 128 MHz. These results motivated the use of remote detection of the magnetic resonance signal using a parallel-plate waveguide together with 3 T clinical scanners, to acquired human leg images. The cut-off frequency of this waveguide is zero for the principal mode, allowing us to overcome the barrier of transmitting waves at lower frequency than 300 MHz or 7 T for protons. These motivated the study of remote detection outside the actual magnet. We performed electromagnetic field simulations of a parallel-plate waveguide and a phantom. The signal transmission was done at 128 MHz and using a circular surface coil located almost 200 cm away for the magnet isocentre. Numerical simulations demonstrated that the magnetic field of the principal mode propagate inside a waveguide outside the magnet. Numerical results were compared with previous experimental-acquired image data under similar conditions.

  19. Clinical Applications of Geometrical Field Matching in Radiotherapy Based on a New Analytical Solution

    SciTech Connect

    Hernandez, Victor; Arenas, Meritxell; Pons, Ferran; Sempau, Josep

    2011-07-01

    A new analytical formalism has been published recently that provides all the parameters necessary for geometrical field matching in radiotherapy. The present work applies the general expressions for craniospinal irradiation, breast irradiation with a supraclavicular half-field, and breast irradiation with a supraclavicular full-field. We also explore the formalism as a tool to analyze and compare different techniques. Field matching is achieved by imposing both parallelism and coincidence between the side planes of adjacent fields. The rotation angles and either the field aperture for a certain isocenter position or the isocenter coordinates for a given field aperture are supplied. All of the already known exact solutions are reproduced. New expressions for the field aperture and for the isocenter coordinates, which were not previously available, are also computed. If tangential fields at a fixed source-to-skin distance are used together with a supraclavicular full-field, different apertures for each tangential field are required to achieve a correct match. If an isocentric technique for the tangential fields or a supraclavicular half-field is used, this complication is avoided. The breast technique with the supraclavicular half-field is recommended, because it presents several advantages with respect to the supraclavicular full-field. This formalism provides a useful tool in cases where matching of adjacent fields is necessary.

  20. The physical characteristics of the 15 MV Varian Clinac 2100C unflattened beam

    NASA Astrophysics Data System (ADS)

    Najem, M. A.; Spyrou, N. M.; Podolyák, Z.; Abolaban, F. A.

    2014-02-01

    A 15 MV photon beam of a Varian Clinac 2100C medical linear accelerator operating with and without a flattening filter was simulated using the Monte Carlo code 'FLUKA' in order to calculate differences in their dosimetric properties. These include: the dose rate, the percentage depth dose on the central axis, the beam profile, the out-of-field dose, the surface dose on a 40×40×40 cm3 water phantom and the neutron contamination. The results obtained showed that the unflattened beam has a dose rate 4.86 times higher than the flattened one. The average out-of-field dose from the edge of the field to the edge of the phantom was reduced by 44%, the neutron fluence at the isocentre was reduced by 77% and the surface neutron dose-equivalent was reduced from 2.11±0.05 to 0.40±0.01 mSv(n) Gy-1(X) after normalising both beams to give the same dose at dmax (the depth of maximum dose). However, the photon surface dose of the unflattened beam increased by 13%. From this information, it can be concluded that the unflattened beam can lead to better treatment outcome and may reduce the beam-on time which may be required for specific cases.

  1. An improved Monte Carlo (MC) dose simulation for charged particle cancer therapy

    SciTech Connect

    Ying, C. K.; Kamil, W. A.; Shuaib, I. L.; Matsufuji, Naruhiro

    2014-02-12

    Heavy-particle therapy such as carbon ion therapy are more popular nowadays because of the nature characteristics of charged particle and almost no side effect to patients. An effective treatment is achieved with high precision of dose calculation, in this research work, Geant4 based Monte Carlo simulation method has been used to calculate the radiation transport and dose distribution. The simulation have the same setting with the treatment room in Heavy Ion Medical Accelerator, HIMAC. The carbon ion beam at the isocentric gantry nozzle for the therapeutic energy of 290 MeV/u was simulated, experimental work was carried out in National Institute of Radiological Sciences, NIRS, Chiba, Japan by using the HIMAC to confirm the accuracy and qualities dose distribution by MC methods. The Geant4 based simulated dose distribution were verified with measurements for Bragg peak and spread out Bragg peak (SOBP) respectively. The verification of results shows that the Bragg peak depth-dose and SOBP distributions in simulation has good agreement with measurements. In overall, the study showed that Geant4 based can be fully applied in the heavy-ion therapy field for simulation, further works need to be carry on to refine and improve the Geant4 MC simulations.

  2. Clinical implementation of a digital tomosynthesis-based seed reconstruction algorithm for intraoperative postimplant dose evaluation in low dose rate prostate brachytherapy

    SciTech Connect

    Brunet-Benkhoucha, Malik; Verhaegen, Frank; Lassalle, Stephanie; Beliveau-Nadeau, Dominic; Reniers, Brigitte; Donath, David; Taussky, Daniel; Carrier, Jean-Francois

    2009-11-15

    Purpose: The low dose rate brachytherapy procedure would benefit from an intraoperative postimplant dosimetry verification technique to identify possible suboptimal dose coverage and suggest a potential reimplantation. The main objective of this project is to develop an efficient, operator-free, intraoperative seed detection technique using the imaging modalities available in a low dose rate brachytherapy treatment room. Methods: This intraoperative detection allows a complete dosimetry calculation that can be performed right after an I-125 prostate seed implantation, while the patient is still under anesthesia. To accomplish this, a digital tomosynthesis-based algorithm was developed. This automatic filtered reconstruction of the 3D volume requires seven projections acquired over a total angle of 60 deg. with an isocentric imaging system. Results: A phantom study was performed to validate the technique that was used in a retrospective clinical study involving 23 patients. In the patient study, the automatic tomosynthesis-based reconstruction yielded seed detection rates of 96.7% and 2.6% false positives. The seed localization error obtained with a phantom study is 0.4{+-}0.4 mm. The average time needed for reconstruction is below 1 min. The reconstruction algorithm also provides the seed orientation with an uncertainty of 10 deg. {+-}8 deg. The seed detection algorithm presented here is reliable and was efficiently used in the clinic. Conclusions: When combined with an appropriate coregistration technique to identify the organs in the seed coordinate system, this algorithm will offer new possibilities for a next generation of clinical brachytherapy systems.

  3. A haptic unit designed for magnetic-resonance-guided biopsy.

    PubMed

    Tse, Z T H; Elhawary, H; Rea, M; Young, I; Davis, B L; Lamperth, M

    2009-02-01

    The magnetic fields present in the magnetic resonance (MR) environment impose severe constraints on any mechatronic device present in its midst, requiring alternative actuators, sensors, and materials to those conventionally used in traditional system engineering. In addition the spatial constraints of closed-bore scanners require a physical separation between the radiologist and the imaged region of the patient. This configuration produces a loss of the sense of touch from the target anatomy for the clinician, which often provides useful information. To recover the force feedback from the tissue, an MR-compatible haptic unit, designed to be integrated with a five-degrees-of-freedom mechatronic system for MR-guided prostate biopsy, has been developed which incorporates position control and force feedback to the operator. The haptic unit is designed to be located inside the scanner isocentre with the master console in the control room. MR compatibility of the device has been demonstrated, showing a negligible degradation of the signal-to-noise ratio and virtually no geometric distortion. By combining information from the position encoder and force sensor, tissue stiffness measurement along the needle trajectory is demonstrated in a lamb liver to aid diagnosis of suspected cancerous tissue. PMID:19278193

  4. Investigation of MR image distortion for radiotherapy treatment planning of prostate cancer

    NASA Astrophysics Data System (ADS)

    Chen, Z.; Ma, C.-M.; Paskalev, K.; Li, J.; Yang, J.; Richardson, T.; Palacio, L.; Xu, X.; Chen, L.

    2006-03-01

    MR imaging based treatment planning for radiotherapy of prostate cancer is limited due to MR imaging system related geometrical distortions, especially for patients with large body sizes. On our 0.23 T open scanner equipped with the gradient distortion correction (GDC) software, the residual image distortions after the GDC were <5 mm within the central 36 cm × 36 cm area for a standard 48 cm field of view (FOV). In order to use MR imaging alone for treatment planning the effect of residual MR distortions on external patient contour determination, especially for the peripheral regions outside the 36 cm × 36 cm area, must be investigated and corrected. In this work, we performed phantom measurements to quantify MR system related residual geometric distortions after the GDC and the effective FOV. Our results show that for patients with larger lateral dimensions (>36 cm), the differences in patient external contours between distortion-free CT images and GDC-corrected MR images were 1-2 cm because of the combination of greater gradient distortion and loss of field homogeneity away from the isocentre and the uncertainties in patient setup during CT and MRI scans. The measured distortion maps were used to perform point-by-point corrections for patients with large dimensions inside the effective FOV. Using the point-by-point method, the geometrical distortion after the GDC were reduced to <3 mm for external contour determination and the effective FOV was expanded from 36 cm to 42 cm.

  5. Effect of MLC tracking latency on conformal volumetric modulated arc therapy (VMAT) plans in 4D stereotactic lung treatment

    PubMed Central

    Bedford, James L.; Fast, Martin F.; Nill, Simeon; McDonald, Fiona M.A.; Ahmed, Merina; Hansen, Vibeke N.; Oelfke, Uwe

    2015-01-01

    Background and purpose The latency of a multileaf collimator (MLC) tracking system used to overcome respiratory motion causes misalignment of the treatment beam with respect to the gross tumour volume, which may result in reduced target coverage. This study investigates the magnitude of this effect. Material and methods Simulated superior–inferior breathing motion was used to construct histograms of isocentre offset with respect to the gross tumour volume (GTV) for a variety of tracking latencies. Dose distributions for conformal volumetric modulated arc therapy (VMAT) arcs were then calculated at a range of offsets and summed according to these displacement histograms. The results were verified by delivering the plans to a Delta4 phantom on a motion platform. Results In the absence of an internal target margin, a tracking latency of 150 ms reduces the GTV D95% by approximately 2%. With a margin of 2 mm, the same drop in dose occurs for a tracking latency of 450 ms. Lung V13Gy is unaffected by a range of latencies. These results are supported by the phantom measurements. Conclusions Assuming that internal motion can be modelled by a rigid translation of the patient, MLC tracking of conformal VMAT can be effectively accomplished in the absence of an internal target margin for substantial breathing motion (4 s period and 20 mm peak–peak amplitude) so long as the system latency is less than 150 ms. PMID:26277856

  6. Inter- and intra-fraction motion during radiation therapy to the whole breast in the supine position: a systematic review.

    PubMed

    Michalski, Andrea; Atyeo, John; Cox, Jennifer; Rinks, Marianne

    2012-10-01

    Inter- and intra-fraction motion during radiation therapy for breast cancer has been a widely researched topic. Recently, however, with the emergence of new technologies and techniques such as intensity modulated radiation therapy (IMRT), field in field, volumetric modulated arc therapy (VMAT), tomotherapy and partial breast irradiation (PBI), the magnitude of this movement has become more important. The aim of this study is to provide a comprehensive summary of the literature relating to the magnitude of motion during radiation therapy for a breast cancer patient. A systematic review of the literature was conducted using Medline, Cinhal, Embase, Scopus and Web of Science. Studies included were limited to women having radical radiation therapy to the whole breast in the supine position. Studies needed to report quantitatively on the magnitude of inter- and intra-fraction motion using electronic portal imaging, port films or kilovoltage imaging techniques. Eighteen articles fitted the selection criteria. The averages of random and systematic error for inter- and intra-fraction movement were reported using central lung distance, central irradiated width, central beam edge to skin distance and cranio-caudal distance measurements, or isocentric matching techniques. Inter-fraction motion was consistently larger than intra-fraction motion but, on average, within a 5 mm tolerance. There were, though, large maximum inter- and intra-fraction variations observed in the measurements of individual patients, which indicate the need for daily inter- and intra- fraction motion management before implementing IMRT, VMAT, tomotherapy or PBI techniques. PMID:23043567

  7. Dose characteristics of in-house-built collimators for stereotactic radiotherapy with a linear accelerator

    NASA Astrophysics Data System (ADS)

    Norrgård, F. Stefan E.; Sipilä, Petri M.; Kulmala, Jarmo A. J.; Minn, Heikki R. I.

    1998-06-01

    Dose characteristics of a stereotactic radiotherapy unit based on a standard Varian Clinac 4/100 4 MV linear accelerator, in-house-built Lipowitz collimators and the SMART stereotactic radiotherapy treatment planning software have been determined. Beam collimation is constituted from the standard collimators of the linear accelerator and a tertiary collimation consisting of a replaceable divergent Lipowitz collimator. Four collimators with isocentre diameters of 15, 25, 35 and 45 mm, respectively, were constructed. Beam characteristics were measured in air, acrylic or water with ionization chamber, photon diode, electron diode, diamond detector and film. Monte Carlo simulation was also applied. The radiation leakage under the collimators was less than 1% at 50 mm depth in water. Specific beam characteristics for each collimator were imported to SMART and dose planning with five non-coplanar converging arcs separated by angles was performed for treatment of a RANDO phantom. Dose verification was made with TLD and radiochromic film. The in-house-built collimators were found to be suitable for stereotactic radiotherapy and patient treatments with this system are in progress.

  8. Electron contamination and build-up doses in conformal radiotherapy fields.

    PubMed

    Hounsell, A R; Wilkinson, J M

    1999-01-01

    The dose in the build-up region depends upon the primary photon beam, backscattered radiation from the patient and contamination radiation from outside the patient. In this paper, a model based on measured data is proposed which allows the build-up dose for arbitrarily shaped treatment fields to be determined. The dose in the build-up region is assumed to comprise a primary photon component and a contamination component that is a function of the field size and shape. This contamination component, for modelling purposes, is subdivided into contributions that correspond to elements of 1 cm by 1 cm cross-sectional area at the plane of the isocentre. The magnitude of these components has been obtained by fitting measured data to an exponential function. The exponent was found to vary linearly with depth for energies between 4 MV and 20 MV. The coefficient decreased linearly with depth at 4, 6 and 8 MV, but exhibited a broad build-up region at 20 MV. The primary component, in the build-up region, could be approximated by a 100 - (100 - PSD) e(-mu d) function, where PSD is the primary surface dose. The values obtained during the fitting procedure were used to calculate dose in the build-up region for arbitrarily shaped fields. Good agreement was found in each case. PMID:10071874

  9. Building motion models of lung tumours from cone-beam CT for radiotherapy applications.

    PubMed

    Martin, James; McClelland, Jamie; Yip, Connie; Thomas, Christopher; Hartill, Clare; Ahmad, Shahreen; O'Brien, Richard; Meir, Ivan; Landau, David; Hawkes, David

    2013-03-21

    A method is presented to build a surrogate-driven motion model of a lung tumour from a cone-beam CT scan, which does not require markers. By monitoring an external surrogate in real time, it is envisaged that the motion model be used to drive gated or tracked treatments. The motion model would be built immediately before each fraction of treatment and can account for inter-fraction variation. The method could also provide a better assessment of tumour shape and motion prior to delivery of each fraction of stereotactic ablative radiotherapy. The two-step method involves enhancing the tumour region in the projections, and then fitting the surrogate-driven motion model. On simulated data, the mean absolute error was reduced to 1 mm. For patient data, errors were determined by comparing estimated and clinically identified tumour positions in the projections, scaled to mm at the isocentre. Averaged over all used scans, the mean absolute error was under 2.5 mm in superior-inferior and transverse directions. PMID:23442367

  10. Targeting accuracy of an image guided gating system for stereotactic body radiotherapy

    NASA Astrophysics Data System (ADS)

    Tenn, Stephen E.; Solberg, Timothy D.; Medin, Paul M.

    2005-12-01

    Recently, a commercial system capable of x-ray image guided patient positioning and respiratory gated delivery has become available. Here we describe the operational principles of this system and investigate its geometric targeting accuracy under controlled conditions. The system tracks breathing via infrared (IR) detection of reflective markers located on the patient's abdomen. Localization kilovoltage (kV) x-rays are triggered from within the gated delivery window portion of the breathing trace and after positioning, the tumour will cross the linac isocentre during gated delivery. We tested geometric accuracy of this system by localizing and delivering gated fields to a moving phantom. Effects of phantom speed, gating window location, timing errors and phantom rotations on positioning and gating accuracy were investigated. The system delivered gated fields to both a moving and static phantom with equal accuracy. The position of the gating window affects accuracy only to the extent that an asymmetric breathing motion could affect dose distribution within its boundaries. Positioning errors were found to be less then 0.5 ± 0.2 mm for phantom rotations up to 5°. We found and corrected a synchronization error caused by a faulty x-ray duration setting and detected a 60 ± 20 ms time delay in our linear accelerator.

  11. Progress Report on the Construction of the Northeast Proton Therapy Center (NPTC) Equipment

    NASA Astrophysics Data System (ADS)

    Jongen, Y.

    1997-05-01

    The IBA proton therapy system selected by the Massachusetts General Hospital (MHG) to equip its new NPTC is presently under construction and test. This equipment includes a 235 MeV isochronous cyclotron, an energy selection system transforming the fixed energy beam extracted from the cyclotron into a variable energy beam, two isocentric gantries fitted with a nozzle, two horizontal beam lines, a robotic patient positioning system, a global control system and a global safety management system. This paper will present a progress report on the equipment construction, with a particular emphasis on the results of the accelerator tests. The cyclotron was tested at the IBA assembly hall at the beginning of 1997. Beam was accelerated up to the energy of 235 MeV, with extracted beam intensities up to 1 μA. The cyclotron, as well as the rest of the equipment, will be progressively installed in the NPTC building during 1997. The acceptance tests of the equipment are foreseen for the end of 1997.

  12. Experimental characterization of two-dimensional pencil beam scanning proton spot profiles.

    PubMed

    Lin, Liyong; Ainsley, Christopher G; McDonough, James E

    2013-09-01

    Dose calculations of pencil beam scanning treatment plans rely on the accuracy of proton spot profiles; not only the primary component but also the broad tail components. Four films are placed at several locations in air and multiple depths in Solidwater® for six selected energies. The films used for the primary components are exposed to 50-200 MU to avoid saturation; the films used for the tail components are exposed to 800, 8000 and 80,000 MU. By applying a pair/magnification method and merging these data, dose kernels down to 10(-4) of the central spot dose can be generated. From these kernels one can calculate the dose-per-MU for different field sizes and shapes. Measurements agree within 1% of dose-kernel-based calculations for output versus field size comparisons. Asymmetric, comet-shaped profile tails have a bigger impact at superficial depths and low energies: the output difference between two orientations at the surface of a rectangular field of 40 mm×200 mm is about 2% at the isocentre at 100 MeV. Integration of these dose kernels from 0 to 40 mm radius shows that the charge deficit in the Bragg peak chamber varies <2% from entrance to the end of range for energies <180 MeV, but exceeds 5% at 225 MeV. PMID:23948730

  13. Experimental verification of motion mitigation of discrete proton spot scanning by re-scanning

    NASA Astrophysics Data System (ADS)

    Schätti, A.; Zakova, M.; Meer, D.; Lomax, A. J.

    2013-12-01

    In order to be able to treat mobile tumours with active, scanned proton therapy, adequate motion mitigation techniques have to be applied. Re-scanning is such an approach, where the interplay effect between tumour motion and treatment delivery is statistically smeared out. Different re-scanning methods have been used for the irradiation of a spherical target volume and motion amplitudes of up to 10 mm. The resulting dose distributions have been captured in two dimensions by imaging a scintillating screen at the iso-centre for different motion starting phases. Dose inhomogeneity increased approximately linearly with motion amplitude, while the influence of motion period and direction was small. Re-scanning the whole target volume reduced the interplay effect more than re-scanning only the iso-energy layers. Even for 10 mm motion amplitude, no hot or cold spots were seen for 10 re-scans of the whole volume. A fast energy change and fast beam scanning is vital for this kind of re-scanning, as available on Gantry 2 at the Paul Scherrer Institute. For larger motion amplitudes, re-scanning should be combined with gating, breath-hold or tracking to reduce the internal target volume.

  14. Design of a superconducting rotating gantry for heavy-ion therapy

    NASA Astrophysics Data System (ADS)

    Iwata, Y.; Noda, K.; Shirai, T.; Murakami, T.; Furukawa, T.; Mori, S.; Fujita, T.; Itano, A.; Shouda, K.; Mizushima, K.; Fujimoto, T.; Ogitsu, T.; Obana, T.; Amemiya, N.; Orikasa, T.; Takami, S.; Takayama, S.; Watanabe, I.

    2012-04-01

    A superconducting rotating gantry for heavy-ion therapy is being designed. This isocentric rotating gantry can transport heavy ions with the maximum energy of 430MeV/u to an isocenter with irradiation angles of over 0-360 degrees, and is further capable of performing three-dimensional raster-scanning irradiation. The combined-function superconducting magnets will be employed for the rotating gantry. The superconducting magnets with optimized beam optics allow a compact gantry design with a large scan size at the isocenter; the length and the radius of the gantry will be approximately 13 and 5.5 m, respectively, which are comparable to those for the existing proton gantries. Furthermore, the maximum scan size at the isocenter is calculated to be as large as approximately 200 mm square for heavy-ion beams at the maximum energy of 430MeV/u. Based on the design of the beam optics, specifications of the superconducting magnets were determined. The superconducting magnets and magnetic-field distributions are designed using a three-dimensional field solver. With the calculated magnetic fields, beam-tracking simulations were performed to verify the design of the superconducting magnets, and concurrently to evaluate the field quality. With calculated beam profiles at the isocenter, we found that the positions of beam spots as well as their size and shape could be well reproduced as designed, proving validity of our design.

  15. Experimental verification of motion mitigation of discrete proton spot scanning by re-scanning.

    PubMed

    Schätti, A; Zakova, M; Meer, D; Lomax, A J

    2013-12-01

    In order to be able to treat mobile tumours with active, scanned proton therapy, adequate motion mitigation techniques have to be applied. Re-scanning is such an approach, where the interplay effect between tumour motion and treatment delivery is statistically smeared out. Different re-scanning methods have been used for the irradiation of a spherical target volume and motion amplitudes of up to 10 mm. The resulting dose distributions have been captured in two dimensions by imaging a scintillating screen at the iso-centre for different motion starting phases. Dose inhomogeneity increased approximately linearly with motion amplitude, while the influence of motion period and direction was small. Re-scanning the whole target volume reduced the interplay effect more than re-scanning only the iso-energy layers. Even for 10 mm motion amplitude, no hot or cold spots were seen for 10 re-scans of the whole volume. A fast energy change and fast beam scanning is vital for this kind of re-scanning, as available on Gantry 2 at the Paul Scherrer Institute. For larger motion amplitudes, re-scanning should be combined with gating, breath-hold or tracking to reduce the internal target volume. PMID:24254249

  16. Experimental characterization of two-dimensional pencil beam scanning proton spot profiles

    NASA Astrophysics Data System (ADS)

    Lin, Liyong; Ainsley, Christopher G.; McDonough, James E.

    2013-09-01

    Dose calculations of pencil beam scanning treatment plans rely on the accuracy of proton spot profiles; not only the primary component but also the broad tail components. Four films are placed at several locations in air and multiple depths in Solidwater® for six selected energies. The films used for the primary components are exposed to 50-200 MU to avoid saturation; the films used for the tail components are exposed to 800, 8000 and 80 000 MU. By applying a pair/magnification method and merging these data, dose kernels down to 10-4 of the central spot dose can be generated. From these kernels one can calculate the dose-per-MU for different field sizes and shapes. Measurements agree within 1% of dose-kernel-based calculations for output versus field size comparisons. Asymmetric, comet-shaped profile tails have a bigger impact at superficial depths and low energies: the output difference between two orientations at the surface of a rectangular field of 40 mm×200 mm is about 2% at the isocentre at 100 MeV. Integration of these dose kernels from 0 to 40 mm radius shows that the charge deficit in the Bragg peak chamber varies <2% from entrance to the end of range for energies <180 MeV, but exceeds 5% at 225 MeV.

  17. The Clatterbridge high-energy neutron therapy facility: specification and performance.

    PubMed

    Bonnett, D E; Blake, S W; Shaw, J E; Bewley, D K

    1988-01-01

    A new high-energy neutron therapy facility has been installed at the Douglas Cyclotron Centre, Clatterbridge Hospital, Merseyside, in order to extend the clinical trials of fast neutrons initiated by the Medical Research Council. The neutron beam is produced by bombarding a beryllium target with 62 MeV protons. The target is isocentrically mounted with the potential for 360 degrees rotation and has a fully variable collimator. This gives a range of rectilinear field sizes from 5 cm x 5 cm to 30 cm x 30 cm. Basic neutron beam data including output, field flatness, penumbra and depth-dose data have been measured. For a 10 cm x 10 cm field, the 50% depth dose occurs at 16.2 cm in water and the output is 1.63 cGy microA-1 min-1 at the depth of dose maximum. The effectiveness of the target shielding and the neutron-induced radioactivity in the treatment head have also been measured. It is concluded that the equipment meets both the design specifications and also fully satisfies criticisms of earlier neutron therapy equipment. A full radiation survey of the centre was also carried out and it was found that radiation levels are low and present no significant hazard to staff. PMID:3126848

  18. Compact multileaf collimator for conformal and intensity modulated fast neutron therapy: Electromechanical design and validation

    SciTech Connect

    Farr, J. B.; Maughan, R. L.; Yudelev, M.; Blosser, E.; Brandon, J.; Horste, T.; Forman, J. D.

    2006-09-15

    The electromechanical properties of a 120-leaf, high-resolution, computer-controlled, fast neutron multileaf collimator (MLC) are presented. The MLC replaces an aging, manually operated multirod collimator. The MLC leaves project 5 mm in the isocentric plane perpendicular to the beam axis. A taper is included on the leaves matching beam divergence along one axis. The 5-mm leaf projection width is chosen to give high-resolution conformality across the entire field. The maximum field size provided is 30x30 cm{sup 2}. To reduce the interleaf transmission a 0.254-mm blocking step is included. End-leaf steps totaling 0.762 mm are also provided allowing opposing leaves to close off within the primary radiation beam. The neutron MLC also includes individual 45 deg. and 60 deg. automated universal tungsten wedges. The automated high-resolution neutron collimation provides an increase in patient throughput capacity, enables a new modality, intensity modulated neutron therapy, and limits occupational radiation exposure by providing remote operation from a shielded console area.

  19. A method for online verification of adapted fields using an independent dose monitor

    SciTech Connect

    Chang Jina; Norrlinger, Bernhard D.; Heaton, Robert K.; Jaffray, David A.; Cho, Young-Bin; Islam, Mohammad K.; Mahon, Robert

    2013-07-15

    Purpose: Clinical implementation of online adaptive radiotherapy requires generation of modified fields and a method of dosimetric verification in a short time. We present a method of treatment field modification to account for patient setup error, and an online method of verification using an independent monitoring system.Methods: The fields are modified by translating each multileaf collimator (MLC) defined aperture in the direction of the patient setup error, and magnifying to account for distance variation to the marked isocentre. A modified version of a previously reported online beam monitoring system, the integral quality monitoring (IQM) system, was investigated for validation of adapted fields. The system consists of a large area ion-chamber with a spatial gradient in electrode separation to provide a spatially sensitive signal for each beam segment, mounted below the MLC, and a calculation algorithm to predict the signal. IMRT plans of ten prostate patients have been modified in response to six randomly chosen setup errors in three orthogonal directions.Results: A total of approximately 49 beams for the modified fields were verified by the IQM system, of which 97% of measured IQM signal agree with the predicted value to within 2%.Conclusions: The modified IQM system was found to be suitable for online verification of adapted treatment fields.

  20. An improved Monte Carlo (MC) dose simulation for charged particle cancer therapy

    NASA Astrophysics Data System (ADS)

    Ying, C. K.; Kamil, W. A.; Shuaib, I. L.; Matsufuji, Naruhiro

    2014-02-01

    Heavy-particle therapy such as carbon ion therapy are more popular nowadays because of the nature characteristics of charged particle and almost no side effect to patients. An effective treatment is achieved with high precision of dose calculation, in this research work, Geant4 based Monte Carlo simulation method has been used to calculate the radiation transport and dose distribution. The simulation have the same setting with the treatment room in Heavy Ion Medical Accelerator, HIMAC. The carbon ion beam at the isocentric gantry nozzle for the therapeutic energy of 290 MeV/u was simulated, experimental work was carried out in National Institute of Radiological Sciences, NIRS, Chiba, Japan by using the HIMAC to confirm the accuracy and qualities dose distribution by MC methods. The Geant4 based simulated dose distribution were verified with measurements for Bragg peak and spread out Bragg peak (SOBP) respectively. The verification of results shows that the Bragg peak depth-dose and SOBP distributions in simulation has good agreement with measurements. In overall, the study showed that Geant4 based can be fully applied in the heavy-ion therapy field for simulation, further works need to be carry on to refine and improve the Geant4 MC simulations.

  1. Poster — Thur Eve — 30: 4D VMAT dose calculation methodology to investigate the interplay effect: experimental validation using TrueBeam Developer Mode and Gafchromic film

    SciTech Connect

    Teke, T; Milette, MP; Huang, V; Thomas, SD

    2014-08-15

    The interplay effect between the tumor motion and the radiation beam modulation during a VMAT treatment delivery alters the delivered dose distribution from the planned one. This work present and validate a method to accurately calculate the dose distribution in 4D taking into account the tumor motion, the field modulation and the treatment starting phase. A QUASAR™ respiratory motion phantom was 4D scanned with motion amplitude of 3 cm and with a 3 second period. A static scan was also acquired with the lung insert and the tumor contained in it centered. A VMAT plan with a 6XFFF beam was created on the averaged CT and delivered on a Varian TrueBeam and the trajectory log file was saved. From the trajectory log file 10 VMAT plans (one for each breathing phase) and a developer mode XML file were created. For the 10 VMAT plans, the tumor motion was modeled by moving the isocentre on the static scan, the plans were re-calculated and summed in the treatment planning system. In the developer mode, the tumor motion was simulated by moving the couch dynamically during the treatment. Gafchromic films were placed in the QUASAR phantom static and irradiated using the developer mode. Different treatment starting phase were investigated (no phase shift, maximum inhalation and maximum exhalation). Calculated and measured isodose lines and profiles are in very good agreement. For each starting phase, the dose distribution exhibit significant differences but are accurately calculated with the methodology presented in this work.

  2. Standard compensators for ENT therapy fields

    SciTech Connect

    Clark, B.G.; Evans, M.D. )

    1988-12-01

    Radiotherapy of the ENT region is frequently applied through two parallel-opposed, lateral fields covering a volume from the maxillary sinus to the base of the neck, with the isocentre close to the angle of the mandible. The large variation in separation throughout this volume, in both the transverse and the coronal planes, leads to field inhomogeneities which are often resolved by the use of custom designed, two-dimensional compensators. This paper presents an alternative method of compensation using a set of one-dimensional, standard compensators applied in the coronal plane which, in conjunction with a wedge in the transverse plane, yields a uniform distribution throughout the treatment volume for the majority of patient configurations. The advantages of this technique are the immediate availability of a computerised treatment plan incorporating the compensator, an increase in the dose homogeneity obtainable over that without compensation and the elimination of any delay which may be incurred by the design and fabrication of custom made compensators.

  3. NOTE: Comprehensive quality assurance for stereotactic radiosurgery treatments

    NASA Astrophysics Data System (ADS)

    Ramaseshan, R.; Heydarian, M.

    2003-07-01

    We have used a commercially available high precision LucyTM phantom to perform comprehensive quality assurance for stereotactic radiosurgery treatments. The quantitative evaluation of system uncertainties included imaging, planning and treatment delivery systems. The quality assurance tests showed that the well-defined targets were identified to within +/-1 mm in all the imaging modalities. The pre-known target volumes were reproduced within 2 cm3 in both MR and CT. The planned target was delivered within 2% of the prescribed dose and to within 2 mm accuracy. The inaccuracy in the isocentre position at the Linac was less than 1.2 mm. The maximum error observed in the depth helmet was 0.5 mm and the overall uncertainty was within 0.23 mm. We have also established a quality assurance program based on the study and proposed the tolerance and the frequency of the tests required to be carried out. The tests were carried out using a Radionics planning system and delivered on a Varian Clinac 2100 linear accelerator machine. These tests also established a base line for future comparisons.

  4. Analytic characterization of linear accelerator radiosurgery dose distributions for fast optimization

    NASA Astrophysics Data System (ADS)

    Meeks, Sanford L.; Bova, Frank J.; Buatti, John M.; Friedman, William A.; Eyster, Brian; Kendrick, Lance A.

    1999-11-01

    Linear accelerator (linac) radiosurgery utilizes non-coplanar arc therapy delivered through circular collimators. Generally, spherically symmetric arc sets are used, resulting in nominally spherical dose distributions. Various treatment planning parameters may be manipulated to provide dose conformation to irregular lesions. Iterative manipulation of these variables can be a difficult and time-consuming task, because (a) understanding the effect of these parameters is complicated and (b) three-dimensional (3D) dose calculations are computationally expensive. This manipulation can be simplified, however, because the prescription isodose surface for all single isocentre distributions can be approximated by conic sections. In this study, the effects of treatment planning parameter manipulation on the dimensions of the treatment isodose surface were determined empirically. These dimensions were then fitted to analytic functions, assuming that the dose distributions were characterized as conic sections. These analytic functions allowed real-time approximation of the 3D isodose surface. Iterative plan optimization, either manual or automated, is achieved more efficiently using this real time approximation of the dose matrix. Subsequent to iterative plan optimization, the analytic function is related back to the appropriate plan parameters, and the dose distribution is determined using conventional dosimetry calculations. This provides a pseudo-inverse approach to radiosurgery optimization, based solely on geometric considerations.

  5. Measurement of inter and intra fraction organ motion in radiotherapy using cone beam CT projection images

    NASA Astrophysics Data System (ADS)

    Marchant, T. E.; Amer, A. M.; Moore, C. J.

    2008-02-01

    A method is presented for extraction of intra and inter fraction motion of seeds/markers within the patient from cone beam CT (CBCT) projection images. The position of the marker is determined on each projection image and fitted to a function describing the projection of a fixed point onto the imaging panel at different gantry angles. The fitted parameters provide the mean marker position with respect to the isocentre. Differences between the theoretical function and the actual projected marker positions are used to estimate the range of intra fraction motion and the principal motion axis in the transverse plane. The method was validated using CBCT projection images of a static marker at known locations and of a marker moving with known amplitude. The mean difference between actual and measured motion range was less than 1 mm in all directions, although errors of up to 5 mm were observed when large amplitude motion was present in an orthogonal direction. In these cases it was possible to calculate the range of motion magnitudes consistent with the observed marker trajectory. The method was shown to be feasible using clinical CBCT projections of a pancreas cancer patient.

  6. Monte Carlo optimization of total body irradiation in a phantom and patient geometry

    NASA Astrophysics Data System (ADS)

    Chakarova, R.; Müntzing, K.; Krantz, M.; Hedin, E.; Hertzman, S.

    2013-04-01

    The objective of this work is to apply a Monte Carlo (MC) accelerator model, validated by experimental data at isocentre distances, to a large-field total body irradiation (TBI) technique and to develop a strategy for individual patient treatment on the basis of MC dose distributions. Calculations are carried out using BEAMnrc/DOSXYZnrc code packages for a 15 MV Varian accelerator. Acceptable agreement is obtained between MC data and measurements in a large water phantom behind a spoiler at source-skin distances (SSD) = 460 cm as well as in a CIRS® thorax phantom. Dose distributions in patients are studied when simulating bilateral beam delivery at a distance of 480 cm to the patient central sagittal plane. A procedure for individual improvement of the dose uniformity is suggested including the design of compensators in a conventional treatment planning system (TPS) and a subsequent update of the dose distribution. It is demonstrated that the dose uniformity for the simple TBI technique can be considerably improved. The optimization strategy developed is straightforward and suitable for clinics where the TPS available is deficient to calculate 3D dose distributions at extended SSD.

  7. Status of the Proton Therapy Project at IUCF and the Midwest Proton Radiotherapy Institute

    NASA Astrophysics Data System (ADS)

    Klein, Susan B.

    2003-08-01

    The first proton therapy patient was successfully treated for astrocytoma using a modified nuclear experimentation beam line and in-house treatment planning in 1993. In 1998, IUCF constructed an eye treatment clinic, and conducted a phase III clinical trial investigating proton radiation treatment of AMD. Treatment was planned using Eyeplan modified to match the IUCF beam characteristics. MPRI was conceptualized in 1996 by a consortium of physicians and physicists. Reconfiguration began in 2000; construction of the achromatic trunk line began in 2001, followed by manufacture of 4 energy selection lines and two fixed horizontal beam treatment lines. Two isocentric, rotational gantries will be installed following completion of the horizontal beam lines. A fifth line will supply the full-time radiation effects research station. Standard proton delivery out of the main stage is specified at 500 nA of 205 MeV. Clinic construction began in April, 2002 and will be completed by mid-December. Design, construction and operation of these proton facilities have been accomplished by the proton therapy group at IUCF.

  8. Design and evaluation of a grid reciprocation scheme for use in digital breast tomosynthesis

    NASA Astrophysics Data System (ADS)

    Patel, Tushita; Sporkin, Helen; Peppard, Heather; Williams, Mark B.

    2016-03-01

    This work describes a methodology for efficient removal of scatter radiation during digital breast tomosynthesis (DBT). The goal of this approach is to enable grid image obscuration without a large increase in radiation dose by minimizing misalignment of the grid focal point (GFP) and x-ray focal spot (XFS) during grid reciprocation. Hardware for the motion scheme was built and tested on the dual modality breast tomosynthesis (DMT) scanner, which combines DBT and molecular breast tomosynthesis (MBT) on a single gantry. The DMT scanner uses fully isocentric rotation of tube and x-ray detector for maintaining a fixed tube-detector alignment during DBT imaging. A cellular focused copper prototype grid with 80 cm focal length, 3.85 mm height, 0.1 mm thick lamellae, and 1.1 mm hole pitch was tested. Primary transmission of the grid at 28 kV tube voltage was on average 74% with the grid stationary and aligned for maximum transmission. It fell to 72% during grid reciprocation by the proposed method. Residual grid line artifacts (GLAs) in projection views and reconstructed DBT images are characterized and methods for reducing the visibility of GLAs in the reconstructed volume through projection image flat-field correction and spatial frequency-based filtering of the DBT slices are described and evaluated. The software correction methods reduce the visibility of these artifacts in the reconstructed volume, making them imperceptible both in the reconstructed DBT images and their Fourier transforms.

  9. A 3D superposition pencil beam dose calculation algorithm for a 60Co therapy unit and its verification by MC simulation

    NASA Astrophysics Data System (ADS)

    Koncek, O.; Krivonoska, J.

    2014-11-01

    The MCNP Monte Carlo code was used to simulate the collimating system of the 60Co therapy unit to calculate the primary and scattered photon fluences as well as the electron contamination incident to the isocentric plane as the functions of the irradiation field size. Furthermore, a Monte Carlo simulation for the polyenergetic Pencil Beam Kernels (PBKs) generation was performed using the calculated photon and electron spectra. The PBK was analytically fitted to speed up the dose calculation using the convolution technique in the homogeneous media. The quality of the PBK fit was verified by comparing the calculated and simulated 60Co broad beam profiles and depth dose curves in a homogeneous water medium. The inhomogeneity correction coefficients were derived from the PBK simulation of an inhomogeneous slab phantom consisting of various materials. The inhomogeneity calculation model is based on the changes in the PBK radial displacement and on the change of the forward and backward electron scattering. The inhomogeneity correction is derived from the electron density values gained from a complete 3D CT array and considers different electron densities through which the pencil beam is propagated as well as the electron density values located between the interaction point and the point of dose deposition. Important aspects and details of the algorithm implementation are also described in this study.

  10. A small animal image guided irradiation system study using 3D dosimeters

    NASA Astrophysics Data System (ADS)

    Qian, Xin; Admovics, John; Wuu, Cheng-Shie

    2015-01-01

    In a high resolution image-guided small animal irradiation platform, a cone beam computed tomography (CBCT) is integrated with an irradiation unit for precise targeting. Precise quality assurance is essential for both imaging and irradiation components. The conventional commissioning techniques with films face major challenges due to alignment uncertainty and labour intensive film preparation and scanning. In addition, due to the novel design of this platform the mouse stage rotation for CBCT imaging is perpendicular to the gantry rotation for irradiation. Because these two rotations are associated with different mechanical systems, discrepancy between rotation isocenters exists. In order to deliver x-ray precisely, it is essential to verify coincidence of the imaging and the irradiation isocenters. A 3D PRESAGE dosimeter can provide an excellent tool for checking dosimetry and verifying coincidence of irradiation and imaging coordinates in one system. Dosimetric measurements were performed to obtain beam profiles and percent depth dose (PDD). Isocentricity and coincidence of the mouse stage and gantry rotations were evaluated with starshots acquired using PRESAGE dosimeters. A single PRESAGE dosimeter can provide 3 -D information in both geometric and dosimetric uncertainty, which is crucial for translational studies.

  11. MOSFET assessment of radiation dose delivered to mice using the Small Animal Radiation Research Platform (SARRP).

    PubMed

    Ngwa, Wilfred; Korideck, Houari; Chin, Lee M; Makrigiorgos, G Mike; Berbeco, Ross I

    2011-12-01

    The Small Animal Radiation Research Platform (SARRP) is a novel isocentric irradiation system that enables state-of-the-art image-guided radiotherapy research to be performed with animal models. This paper reports the results obtained from investigations assessing the radiation dose delivered by the SARRP to different anatomical target volumes in mice. Surgically implanted metal oxide semiconductor field effect transistors (MOSFET) dosimeters were employed for the dose assessment. The results reveal differences between the calculated and measured dose of -3.5 to 0.5%, -5.2 to -0.7%, -3.9 to 0.5%, -5.9 to 2.5%, -5.5 to 0.5%, and -4.3 to 0% for the left kidney, liver, pancreas, prostate, left lung, and brain, respectively. Overall, the findings show less than 6% difference between the delivered and calculated dose, without tissue heterogeneity corrections. These results provide a useful assessment of the need for tissue heterogeneity corrections in SARRP dose calculations for clinically relevant tumor model sites. PMID:21962005

  12. X-ray Sources by Energy Recovered Linacs and Their Needed R&D

    SciTech Connect

    Benson, Stephen; Douglas, David; Dowell, David; Hernandez-Garcia, Carlos; Kayran, D; Krafft, Geoffrey; Legg, Robert; Moog, E; Obina, T; Rimmer, Robert; Yakimenko, V

    2011-05-01

    In this paper we review the current state of research on energy recovered linacs as drivers for future X-ray sources. For many types of user experiments, such sources may have substantial advantages compared to the workhorse sources of the present: high energy storage rings. Energy recovered linacs need to be improved beyond present experience in both energy and average current to support this application. To build an energy recovered linac based X-ray user facility presents many interesting challenges. We present summaries on the Research and Development (R&D) topics needed for full development of such a source, including the discussion at the Future Light Sources Workshop held in Gaithersburg, Maryland on September 15- 17, 2009. A rst iteration of an R&D plan is presented that is founded on the notion of building a set of succeedingly larger test accelerators exploring cathode physics, high average current injector physics, and beam recirculation and beam energy recovery at high average current. Our basic conclusion is that a reviewable design of such a source can be developed after an R&D period of ve to ten years.

  13. Neutron time-of-flight spectroscopy measurement using a waveform digitizer

    NASA Astrophysics Data System (ADS)

    Liu, Long-Xiang; Wang, Hong-Wei; Ma, Yu-Gang; Cao, Xi-Guang; Cai, Xiang-Zhou; Chen, Jin-Gen; Zhang, Gui-Lin; Han, Jian-Long; Zhang, Guo-Qiang; Hu, Ji-Feng; Wang, Xiao-He

    2016-05-01

    The photoneutron source (PNS, phase 1), an electron linear accelerator (linac)-based pulsed neutron facility that uses the time-of-flight (TOF) technique, was constructed for the acquisition of nuclear data from the Thorium Molten Salt Reactor (TMSR) at the Shanghai Institute of Applied Physics (SINAP). The neutron detector signal used for TOF calculation, with information on the pulse arrival time, pulse shape, and pulse height, was recorded by using a waveform digitizer (WFD). By using the pulse height and pulse-shape discrimination (PSD) analysis to identify neutrons and γ-rays, the neutron TOF spectrum was obtained by employing a simple electronic design, and a new WFD-based DAQ system was developed and tested in this commissioning experiment. The DAQ system developed is characterized by a very high efficiency with respect to millisecond neutron TOF spectroscopy. Supported by Strategic Priority Research Program of the Chinese Academy of Science(TMSR) (XDA02010100), National Natural Science Foundation of China(NSFC)(11475245,No.11305239), Shanghai Key Laboratory of Particle Physics and Cosmology (11DZ2260700)

  14. Overview of High Power Vacuum Dry RF Load Designs

    SciTech Connect

    Krasnykh, Anatoly

    2015-08-27

    A specific feature of RF linacs based on the pulsed traveling wave (TW) mode of operation is that only a portion of the RF energy is used for the beam acceleration. The residual RF energy has to be terminated into an RF load. Higher accelerating gradients require higher RF sources and RF loads, which can stably terminate the residual RF power. RF feeders (from the RF source though the accelerating section to the load) are vacuumed to transmit multi-megawatt high power RF. This overview will outline vacuumed RF loads only. A common method to terminate multi-MW RF power is to use circulated water (or other liquid) as an absorbing medium. A solid dielectric interface (a high quality ceramic) is required to separate vacuum and liquid RF absorber mediums. Using such RF load approaches in TW linacs is troubling because there is a fragile ceramic window barrier and a failure could become catastrophic for linac vacuum and RF systems. Traditional loads comprising of a ceramic disk have limited peak and average power handling capability and are therefore not suitable for high gradient TW linacs. This overview will focus on ''vacuum dry'' or ''all-metal'' loads that do not employ any dielectric interface between vacuum and absorber. The first prototype is an original design of RF loads for the Stanford Two-Mile Accelerator.

  15. High-intensity positron microprobe at Jefferson Lab

    SciTech Connect

    Golge, Serkan; Vlahovic, Branislav; Wojtsekhowski, Bogdan B.

    2014-06-19

    We present a conceptual design for a novel continuous wave electron-linac based high-intensity slow-positron production source with a projected intensity on the order of 1010 e+/s. Reaching this intensity in our design relies on the transport of positrons (T+ below 600 keV) from the electron-positron pair production converter target to a low-radiation and low-temperature area for moderation in a high-efficiency cryogenic rare gas moderator, solid Ne. The performance of the integrated beamline has been verified through computational studies. The computational results include Monte Carlo calculations of the optimized electron/positron beam energies, converter target thickness, synchronized raster system, transport of the beam from the converter target to the moderator, extraction of the beam from the channel, and moderation efficiency calculations. For the extraction of positrons from the magnetic channel a magnetic field terminator plug prototype has been built and experimental data on the effectiveness of this prototype are presented. The dissipation of the heat away from the converter target and radiation protection measures are also discussed.

  16. High-intensity positron microprobe at Jefferson Lab

    DOE PAGESBeta

    Golge, Serkan; Vlahovic, Branislav; Wojtsekhowski, Bogdan B.

    2014-06-19

    We present a conceptual design for a novel continuous wave electron-linac based high-intensity slow-positron production source with a projected intensity on the order of 1010 e+/s. Reaching this intensity in our design relies on the transport of positrons (T+ below 600 keV) from the electron-positron pair production converter target to a low-radiation and low-temperature area for moderation in a high-efficiency cryogenic rare gas moderator, solid Ne. The performance of the integrated beamline has been verified through computational studies. The computational results include Monte Carlo calculations of the optimized electron/positron beam energies, converter target thickness, synchronized raster system, transport of themore » beam from the converter target to the moderator, extraction of the beam from the channel, and moderation efficiency calculations. For the extraction of positrons from the magnetic channel a magnetic field terminator plug prototype has been built and experimental data on the effectiveness of this prototype are presented. The dissipation of the heat away from the converter target and radiation protection measures are also discussed.« less

  17. Dechirper wakefields for short bunches

    NASA Astrophysics Data System (ADS)

    Bane, Karl; Stupakov, Gennady

    2016-06-01

    In previous work (Bane and Stupakov, 2015 [1]) general expressions, valid for arbitrary bunch lengths, were derived for the wakefields of corrugated structures with flat geometry, such as is used in the RadiaBeam/LCLS dechirper. However, the bunch at the end of linac-based X-ray FELs-like the LCLS-is extremely short, and for short bunches the wakes can be considerably simplified. In this work, we first derive analytical approximations to the short-range wakes. These are generalized wakes, in the sense that their validity is not limited to a small neighborhood of the symmetry axis, but rather extends to arbitrary transverse offsets of driving and test particles. The validity of these short-bunch wakes holds not only for the corrugated structure, but rather for any flat structure whose beam-cavity interaction can be described by a surface impedance. We use these wakes to obtain, for a short bunch passing through a dechirper: estimates of the energy loss as function of gap, the transverse kick as a function of beam offset, the slice energy spread increase, and the emittance growth. In the Appendix, a more accurate derivation-than that is found in Bane and Stupakov (2015) [1]-of the arbitrary bunch length wakes is performed; we find full agreement with the earlier results, provided the bunches are short compared to the dechirper gap, which is normally the regime of interest.

  18. Time-resolved pump-probe experiments at the LCLS

    SciTech Connect

    Glownia, James; Cryan, J.; Andreasson, J.; Belkacem, A.; Berrah, N.; Blaga, C.L.; Bostedt, C.; Bozek, J.; DiMauro, L.F.; Fang, L.; Frisch, J.; Gessner, O.; Guhr, M.; Hajdu, J.; Hertlein, M.P.; Hoener, M.; Huang, G.; Kornilov, O.; Marangos, J.P.; March, A.M.; McFarland, B.K.; /SLAC /Stanford U., Phys. Dept. /SLAC /IRAMIS, Saclay /Stanford U., Phys. Dept. /Georgia Tech /Argonne /Kansas State U. /SLAC /Stanford U., Phys. Dept. /SLAC /Stanford U., Appl. Phys. Dept. /Stanford U., Appl. Phys. Dept. /SLAC /LBNL /Argonne /SLAC /SLAC /Stanford U., Appl. Phys. Dept. /Stanford U., Phys. Dept.

    2011-08-12

    The first time-resolved x-ray/optical pump-probe experiments at the SLAC Linac Coherent Light Source (LCLS) used a combination of feedback methods and post-analysis binning techniques to synchronize an ultrafast optical laser to the linac-based x-ray laser. Transient molecular nitrogen alignment revival features were resolved in time-dependent x-ray-induced fragmentation spectra. These alignment features were used to find the temporal overlap of the pump and probe pulses. The strong-field dissociation of x-ray generated quasi-bound molecular dications was used to establish the residual timing jitter. This analysis shows that the relative arrival time of the Ti:Sapphire laser and the x-ray pulses had a distribution with a standard deviation of approximately 120 fs. The largest contribution to the jitter noise spectrum was the locking of the laser oscillator to the reference RF of the accelerator, which suggests that simple technical improvements could reduce the jitter to better than 50 fs.

  19. Outcome of Elderly Patients with Meningioma after Image-Guided Stereotactic Radiotherapy: A Study of 100 Cases

    PubMed Central

    Budach, Volker; Graaf, Lukas; Gollrad, Johannes; Badakhshi, Harun

    2015-01-01

    Introduction. Incidence of meningioma increases with age. Surgery has been the mainstay treatment. Elderly patients, however, are at risk of severe morbidity. Therefore, we conducted this study to analyze long-term outcomes of linac-based fractionated stereotactic radiotherapy (FSRT) for older adults (aged ≥65 years) with meningioma and determine prognostic factors. Materials and Methods. Between October 1998 and March 2009, 100 patients (≥65, median age, 71 years) were treated with FSRT for meningioma. Two patients were lost to follow-up. Eight patients each had grade I and grade II meningiomas, and five patients had grade III meningiomas. The histology was unknown in 77 cases (grade 0). Results. The median follow-up was 37 months, and 3-year, 5-year, and 10-year progression-free survival (PFS) rates were 93.7%, 91.1%, and 82%. Patients with grade 0/I meningioma showed 3- and 5-year PFS rates of 98.4% and 95.6%. Patients with grade II or III meningiomas showed 3-year PFS rates of 36%. 93.8% of patients showed local tumor control. Multivariate analysis did not indicate any significant prognostic factors. Conclusion. FSRT may play an important role as a noninvasive and safe method in the clinical management of older patients with meningioma. PMID:26101778

  20. A novel phantom model for mouse tumor dose assessment under MV beams.

    PubMed

    Gossman, Michael S; Das, Indra J; Sharma, Subhash C; Lopez, Jeffrey P; Howard, Candace M; Claudio, Pier

    2011-12-01

    In order to determine a mouse's dose accurately and prior to engaging in live mouse radiobiological research, a tissue-equivalent tumor-bearing phantom mouse was constructed and bored to accommodate detectors. Comparisons were made among four different types of radiation detectors, each inserted into the mouse phantom for radiation measurement under a 6 MV linear accelerator beam. Dose detection response from a diode, thermoluminescent dosimeters, and metal-oxide semiconductor field-effect transistors were used and compared to that of a reference pinpoint ionization chamber. A computerized treatment planning system was also directly compared to the chamber. Each detector system demonstrated results similar to the dose computed by the treatment planning system, although some differences were noted. The average disagreement from an accelerator calibrated output dose prescription in the range of 200-400 cGy was -0.4% ± 0.5 σ for the diode, -2.4% ± 2.6 σ for the TLD, -2.9% ± 5.0 σ for the MOSFET, and +1.3% ± 1.4 σ for the treatment planning system. This phantom mouse design is unique, simple, reproducible, and therefore recommended as a standard approach to dosimetry for radiobiological mouse studies by means of any of the detectors used in this study. The authors fully advocate for treatment planning modeling when possible prior to linac-based dose delivery. PMID:22048493

  1. Electron Bunch Shape Measurements Using Electro-optical Spectral Decoding

    NASA Astrophysics Data System (ADS)

    Borysenko, A.; Hiller, N.; Müller, A.-S.; Steffen, B.; Peier, P.; Ivanisenko, Y.; Ischebeck, R.; Schlott, V.

    Longitudinal diagnostics of the electron bunch shapes play a crucial role in the operation of linac-based light sources. Electro-optical techniques allow us to measure the longitudinal electron bunch profiles non-destructively on a shot-by-shot basis. Here we present results from measurements of electron bunches with a length of 200-900 fs rms at the Swiss FEL Injector Test Facility. All the measurements were done using an Yb-doped fibre laser system (with a central wavelength of a 1050 nm) and a GaP crystal. The technique of electro-optical spectral decoding (EOSD) was applied and showed great capabilities to measure bunch shapes down to around 370 fs rms. Measurements were performed for different electron energies to study the expected distortions of the measured bunch profile due to the energy-dependent widening of the electric field, which plays a role for low beam energies below and around 40 MeV. The studies provide valuable input for the design of the EOSD monitors for the compact linear accelerator FLUTE that is currently under commissioning at the Karslruhe Institute of Technology (KIT).

  2. A Comparison of Helical Intensity-Modulated Radiotherapy, Intensity-Modulated Radiotherapy, and 3D-Conformal Radiation Therapy for Pancreatic Cancer

    SciTech Connect

    Poppe, Matthew M.; Narra, Venkat; Yue, Ning J.; Zhou Jinghao; Nelson, Carl; Jabbour, Salma K.

    2011-01-01

    We assessed dosimetric differences in pancreatic cancer radiotherapy via helical intensity-modulated radiotherapy (HIMRT), linac-based IMRT, and 3D-conformal radiation therapy (3D-CRT) with regard to successful plan acceptance and dose to critical organs. Dosimetric analysis was performed in 16 pancreatic cases that were planned to 54 Gy; both post-pancreaticoduodenectomy (n = 8) and unresected (n = 8) cases were compared. Without volume modification, plans met constraints 75% of the time with HIMRT and IMRT and 13% with 3D-CRT. There was no statistically significantly improvement with HIMRT over conventional IMRT in reducing liver V35, stomach V45, or bowel V45. HIMRT offers improved planning target volume (PTV) dose homogeneity compared with IMRT, averaging a lower maximum dose and higher volume receiving the prescription dose (D100). HIMRT showed an increased mean dose over IMRT to bowel and liver. Both HIMRT and IMRT offer a statistically significant improvement over 3D-CRT in lowering dose to liver, stomach, and bowel. The results were similar for both unresected and resected patients. In pancreatic cancer, HIMRT offers improved dose homogeneity over conventional IMRT and several significant benefits to 3D-CRT. Factors to consider before incorporating IMRT into pancreatic cancer therapy are respiratory motion, dose inhomogeneity, and mean dose.

  3. Assessments of Sequential Intensity Modulated Radiation Therapy Boost (SqIB) Treatments Using HART

    NASA Astrophysics Data System (ADS)

    Pyakuryal, Anil

    2009-05-01

    A retrospective study was pursued to evaluate the SqIB treatments performed on ten head and neck cancer patients(n=10).Average prescription doses (PDs) of 39 Gy,15Gy and 17.8Gy were delivered consecutively from larger to smaller planning target volumes(ptvs) in three different treatment plans using 6 MV X-ray photon beams from a Linear accelerator (SLA Linac, Elekta) on BID weak on-weak off schedules. These plans were statistically evaluated on basis of plan indices (PIs),dose response of targets and critical structures, and dose tolerance(DT) of various organs utilizing the DVH analysis automated software known as Histogram Analysis in Radiation Therapy-HART(S.Jang et al., 2008, Med Phys 35, p.2812). Mean SqIB PIs were found consistent with the reported values for varying radio-surgical systems.The 95.5%(n=10)of each ptvs and the gross tumor volume also received 95% (n=10)of PDs in treatments. The average volume of ten organs (N=10) affected by each PDs shrank with decreasing size of ptvs in above plans.A largest volume of Oropharynx (79%,n=10,N=10) irradiated at PD, but the largest volume of Larynx (98%, n=10, N=10) was vulnerable to DT of structure (TD50).Thus, we have demonstrated the efficiency and accuracy of HART in the assessment of Linac based plans in radiation therapy treatments of cancer.

  4. Application of Histogram Analysis in Radiation Therapy (HART) in Intensity Modulation Radiation Therapy (IMRT) Treatments

    NASA Astrophysics Data System (ADS)

    Pyakuryal, Anil

    2009-03-01

    A carcinoma is a malignant cancer that emerges from epithelial cells in structures through out the body.It invades the critical organs, could metastasize or spread to lymph nodes.IMRT is an advanced mode of radiation therapy treatment for cancer. It delivers more conformal doses to malignant tumors sparing the critical organs by modulating the intensity of radiation beam.An automated software, HART (S. Jang et al.,2008,Med Phys 35,p.2812) was used for efficient analysis of dose volume histograms (DVH) for multiple targets and critical organs in four IMRT treatment plans for each patient. IMRT data for ten head and neck cancer patients were exported as AAPM/RTOG format files from a commercial treatment planning system at Northwestern Memorial Hospital (NMH).HART extracted DVH statistics were used to evaluate plan indices and to analyze dose tolerance of critical structures at prescription dose (PD) for each patient. Mean plan indices (n=10) were found to be in good agreement with published results for Linac based plans. The least irradiated volume at tolerance dose (TD50) was observed for brainstem and the highest volume for larynx in SIB treatment techniques. Thus HART, an open source platform, has extensive clinical implications in IMRT treatments.

  5. RF study and 3-D simulations of a side-coupling thermionic RF-gun

    NASA Astrophysics Data System (ADS)

    Rimjaem, S.; Kusoljariyakul, K.; Thongbai, C.

    2014-02-01

    A thermionic RF-gun for generating ultra-short electron bunches was optimized, developed and used as a source at a linac-based THz radiation research laboratory of the Plasma and Beam Physics Research Facility, Chiang Mai University, Thailand. The RF-gun is a π/2-mode standing wave structure, which consists of two S-band accelerating cells and a side-coupling cavity. The 2856 MHz RF wave is supplied from an S-band klystron to the gun through the waveguide input-port at the cylindrical wall of the second cell. A fraction of the RF power is coupled from the second cell to the first one via a side-coupling cavity. Both the waveguide input-port and the side-coupling cavity lead to an asymmetric geometry of the gun. RF properties and electromagnetic field distributions inside the RF-gun were studied and numerically simulated by using computer codes SUPERFISH 7.19 and CST Microwave Studio 2012©. RF characterizations and tunings of the RF-gun were performed to ensure the reliability of the gun operation. The results from 3D simulations and measurements are compared and discussed in this paper. The influence of asymmetric field distributions inside the RF-gun on the electron beam properties was investigated via 3D beam dynamics simulations. A change in the coupling-plane of the side-coupling cavity is suggested to improve the gun performance.

  6. Total scalp irradiation using helical tomotherapy

    SciTech Connect

    Orton, Nigel . E-mail: nporton@facstaff.wisc.edu; Jaradat, Hazim; Welsh, James; Tome, Wolfgang

    2005-09-30

    Homogeneous irradiation of the scalp poses technical and dosimetric challenges due to the extensive, superficial, curved treatment volume. Conventional treatments on a linear accelerator use multiple matched electron fields or a combination of electron and photon fields. Problems with these techniques include dose heterogeneity in the target due to varying source-to-skin distance (SSD) and angle of beam incidence, significant dose to the brain, and the potential for overdose or underdose at match lines between the fields. Linac-based intensity-modulated radiation therapy (IMRT) plans have similar problems. This work presents treatment plans for total scalp irradiation on a helical tomotherapy machine. Helical tomotherapy is well-suited for scalp irradiation because it has the ability to deliver beamlets that are tangential to the scalp at all points. Helical tomotherapy also avoids problems associated with field matching and use of more than one modality. Tomotherapy treatment plans were generated and are compared to plans for treatment of the same patient on a linac. The resulting tomotherapy plans show more homogeneous target dose and improved critical structure dose when compared to state-of-the-art linac techniques. Target equivalent uniform dose (EUD) for the best tomotherapy plan was slightly higher than for the linac plan, while the volume of brain tissue receiving over 30 Gy was reduced by two thirds. Furthermore, the tomotherapy plan can be more reliably delivered than linac treatments, because the patient is aligned prior to each treatment based on megavoltage computed tomography (MVCT)

  7. SU-C-303-01: Activation-Induced Cytidine Deaminase Confers Cancer Resistance to Radiation Therapy

    SciTech Connect

    Yi, S; La Count, S; Liu, J; Bai, X; Lu, L

    2015-06-15

    Purpose: To study the role of activation-induced cytidine deaminase (AID) in malignant cell resistance to radiation therapy. Methods: We first developed several small devices that could be used to adopt radiation beams from clinical high dose rate brachy therapy (HDR) or linac-based megavoltage machines to perform pre-clinical cell and mouse experiments. Then we used these devices to deliver radiation to AID-positive and AID-silenced cancer cells or tumors formed by these cells in mice. Cells and mice bearing tumors received the same dose under the same experimental conditions. For cells, we observed the apoptosis and the cell survival rate over time. For mice bearing tumors, we measured and recorded the tumor sizes every other day for 4 weeks. Results: For cell experiments, we found that the AID-positive cells underwent much less apoptosis compared with AID-silenced cells upon radiation. And for mouse experiments, we found that AID-positive tumors grew significantly faster than the AID-silenced tumors despite of receiving the same doses of radiation. Conclusion: Our study suggests that AID may confer cancer resistance to radiation therapy, and AID may be a significant biomarker predicting cancer resistance to radiation therapy for certain cancer types.

  8. Wakefield computations for a corrugated pipe as a beam dechirper for FEL applications

    SciTech Connect

    Ng, C. K.; Bane, K. L.F.

    2015-06-09

    A beam “dechirper” based on a corrugated, metallic vacuum chamber has been proposed recently to cancel residual energy chirp in a beam before it enters the undulator in a linac-based X-ray FEL. Rather than the round geometry that was originally proposed, we consider a pipe composed of two parallel plates with corrugations. The advantage is that the strength of the wake effect can be tuned by adjusting the separation of the plates. The separation of the plates is on the order of millimeters, and the corrugations are fractions of a millimeter in size. The dechirper needs to be meters long in order to provide sufficient longitudinal wakefield to cancel the beam chirp. Considerable computation resources are required to determine accurately the wakefield for such a long structure with small corrugation gaps. Combining the moving window technique and parallel computing using multiple processors, the time domain module in the parallel finite-element electromagnetic suite ACE3P allows efficient determination of the wakefield through convergence studies. In this paper, we will calculate the longitudinal, dipole and quadrupole wakefields for the dechirper and compare the results with those of analytical and field matching approaches.

  9. Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues

    PubMed Central

    Mascarin, Maurizio; Giugliano, Francesca Maria; Coassin, Elisa; Drigo, Annalisa; Chiovati, Paola; Dassie, Andrea; Franchin, Giovanni; Minatel, Emilio; Trovò, Mauro Gaetano

    2011-01-01

    Helical Tomotherapy (HT) is a highly conformal image-guided radiation technique, introduced into clinical routine in 2006 at the Centro di Riferimento Oncologico Aviano (Italy). With this new technology, intensity-modulated radiotherapy (IMRT) is delivered using a helicoidal method. Here we present our dosimetric experiences using HT in 100 children, adolescents and young adults treated from May 2006 to February 2011. The median age of the patients was 13 years (range 1–24). The most common treated site was the central nervous system (50; of these, 24 were craniospinal irradiations), followed by thorax (22), head and neck (10), abdomen and pelvis (11), and limbs (7). The use of HT was calculated in accordance to the target dose conformation, the target size and shape, the dose to critical organs adjacent to the target, simultaneous treatment of multiple targets, and re-irradiation. HT has demonstrated to improve target volume dose homogeneity and the sparing of critical structures, when compared to 3D Linac-based radiotherapy (RT). In standard cases this technique represented a comparable alternative to IMRT delivered with conventional linear accelerator. In certain cases (e.g., craniospinal and pleural treatments) only HT generated adequate treatment plans with good target volume coverage. However, the gain in target conformality should be balanced with the spread of low-doses to distant areas. This remains an open issue for the potential risk of secondary malignancies (SMNs) and longer follow-up is mandatory. PMID:24213120

  10. Beam tuning

    SciTech Connect

    Pardo, R.C.; Zinkann, G.P.

    1995-08-01

    A program for configuring the linac, based on previously run configurations for any desired beam was used during the past year. This program uses only a small number of empirical tunes to scale resonator fields to properly accelerate a beam with a different charge-to-mass (q/A) ratio from the original tune configuration. The program worked very well for the PII linac section where we can easily match a new beam`s arrival phase and velocity to the tuned value. It was also fairly successful for the Booster and ATLAS sections of the linac, but not as successful as for the PII linac. Most of the problems are associated with setting the beam arrival time correctly for each major linac section. This problem is being addressed with the development of the capacitive pickup beam phase monitor discussed above. During the next year we expect to improve our ability to quickly configure the linac for new beams and reduce the time required for linac tuning. Already the time required for linac tuning as a percentage of research hours has decreased from 22% in FY 1993 to 15% in the first quarter of FY 1995.

  11. High-intensity positron microprobe at the Thomas Jefferson National Accelerator Facility

    SciTech Connect

    Golge, S. Vlahovic, B.; Wojtsekhowski, B.

    2014-06-21

    We present a conceptual design for a novel continuous wave electron-linac based high-intensity high-brightness slow-positron production source with a projected intensity on the order of 10{sup 10 }e{sup +}/s. Reaching this intensity in our design relies on the transport of positrons (T{sub +} below 600 keV) from the electron-positron pair production converter target to a low-radiation and low-temperature area for moderation in a high-efficiency cryogenic rare gas moderator, solid Ne. This design progressed through Monte Carlo optimizations of: electron/positron beam energies and converter target thickness, transport of the e{sup +} beam from the converter to the moderator, extraction of the e{sup +} beam from the magnetic channel, a synchronized raster system, and moderator efficiency calculations. For the extraction of e{sup +} from the magnetic channel, a magnetic field terminator plug prototype has been built and experimental results on the effectiveness of the prototype are presented. The dissipation of the heat away from the converter target and radiation protection measures are also discussed.

  12. A stereotactic radiation therapy device for retinoblastoma using a noncircular collimator and intensity filter.

    PubMed

    Cormack, R A; Kooy, H M; Bellerive, M R; Loeffler, J S; Petersen, R A; Tarbell, N J

    1998-08-01

    The proximity of the lens to the retina makes the treatment of retinoblastoma a challenge for external beam radiation therapy. The approximately 1 mm separation between the posterior edge of the lens and the anterior region of the retina causes a trade-off between coverage of the entire retina and excessive dose to the lens. A stereotactic, LINAC based, lens sparing technique for treating retinoblastoma is presented. The technique uses noncoplanar arcs with the lens at isocenter. A special noncircular collimator blocks the lens but it also causes the dose distribution to vary across the retina. A fluence modulation filter is used to reduce the dose inhomogeneity across the target. The resulting dose distribution is roughly hemispheric, providing both anterior coverage of the retina and lens blocking unlike conventional techniques. The method used to develop the collimator and filter assembly is presented. Dosimetry of the assembly was carried out using radiochromic film, and the results were entered in a treatment planning system. The dose distribution as measured in a phantom is provided and compared to calculations. PMID:9725131

  13. X-ray Sources by Energy Recovered Linacs and Their Needed R&D

    SciTech Connect

    Geoffrey Krafft, Stephen Benson, Michael Borland, David Douglas, David Dowell, Carlos Hernandez-Garcia, Dmitry Kayran, Robert Legg, Elizabeth Moog, Takashi Obina, Robert Rimmer, Vitaly Yakimenko

    2011-05-01

    In this paper we review the current state of research on energy recovered linacs as drivers for future X-ray sources. For many types of user experiments, such sources may have substantial advantages compared to the workhorse sources of the present: high energy storage rings. Energy recovered linacs need to be improved beyond present experience in both energy and average current to support this application. To build an energy recovered linac based X-ray user facility presents many interesting challenges. We present summaries on the Research and Development (R&D) topics needed for full development of such a source, including the discussion at the Future Light Sources Workshop held in Gaithersberg, Maryland on September 15-17, 2009. A first iteration of an R&D plan is presented that is founded on the notion of building a set of succeedingly larger test accelerators exploring cathode physics, high average current injector physics, and beam recirculation and beam energy recovery at high average current. Our basic conclusion is that a reviewable design of such a source can be developed after an R&D period of reasonably short duration.

  14. Study for a proposed Phase I Energy Recovery Linac (ERL) Synchrotron Light Source at Cornell University

    SciTech Connect

    Sol M. Gruner and Maury Tigner, eds.; Ivan Bazarov; Sergey Belomestnykh; Don Bilderback; Ken Finkelstein; Ernie Fontes; Steve Gray; Sol M. Gruner; Geoff Krafft; Lia Merminga; Hasan Padamsee; Ray Helmke; Qun Shen; Joe Rogers; Charles Sinclair; Richard Talman; Maury Tigner

    2001-07-01

    Synchrotron radiation (SR) has become an essential and rapidly growing tool across the sciences and engineering. World-wide, about 70 SR sources are in various stages of operation, construction, or planning, representing a cumulative investment on many billions of dollars and serving a growing research community well in excess of 10,000 scientists. To date, all major SR x-ray facilities are based on electron (or positron) storage rings. Given the expected continued growth, importance and expense of SR sources, it is important to ask if there are alternatives to the storage ring SR source which offer advantages of capability or cost. A step in this direction is being taken by the SR community with the proposed developments of linac-based x-ray free-electron lasers (XFELs) utilizing the self-amplified spontaneous emission process (SASE). However, the versatility of modern developments in accelerator physics, as applied to synchrotron radiation, is not limited to storage rings or XFELs. New developments in laser driven photoinjectors and superconducting linac technology open new and exciting possibilities for novel SR-generating machines which offer extraordinary capabilities and promise to catalyze whole new areas of SR-based science.

  15. Positron microprobe at LLNL

    SciTech Connect

    Asoka, P; Howell, R; Stoeffl, W

    1998-11-01

    The electron linac based positron source at Lawrence Livermore National Laboratory (LLNL) provides the world's highest current beam of keV positrons. We are building a positron microprobe that will produce a pulsed, focused positron beam for 3-dimensional scans of defect size and concentration with sub-micron resolution. The widely spaced and intense positron packets from the tungsten moderator at the end of the 100 MeV LLNL linac are captured and trapped in a magnetic bottle. The positrons are then released in 1 ns bunches at a 20 MHz repetition rate. With a three-stage re-moderation we will compress the cm-sized original beam to a 1 micro-meter diameter final spot on the target. The buncher will compress the arrival time of positrons on the target to less than 100 ps. A detector array with up to 60 BaF2 crystals in paired coincidence will measure the annihilation radiation with high efficiency and low background. The energy of the positrons can be varied from less than 1 keV up to 50 keV.

  16. Longitudinal Profile Diagnostic Scheme with Subfemtosecond Resolution for High-Brightness Electron Beams

    SciTech Connect

    Andonian, G.; Hemsing, E.; Xiang, D.; Musumeci, P.; Murokh, A.; Tochitsky, S.; Rosenzweig, J.B.; /UCLA

    2012-05-03

    High-resolution measurement of the longitudinal profile of a relativistic electron beam is of utmost importance for linac based free-electron lasers and other advanced accelerator facilities that employ ultrashort bunches. In this paper, we investigate a novel scheme to measure ultrashort bunches (subpicosecond) with exceptional temporal resolution (hundreds of attoseconds) and dynamic range. The scheme employs two orthogonally oriented deflecting sections. The first imparts a short-wavelength (fast temporal resolution) horizontal angular modulation on the beam, while the second imparts a long-wavelength (slow) angular kick in the vertical dimension. Both modulations are observable on a standard downstream screen in the form of a streaked sinusoidal beam structure. We demonstrate, using scaled variables in a quasi-1D approximation, an expression for the temporal resolution of the scheme and apply it to a proof-of-concept experiment at the UCLA Neptune high-brightness injector facility. The scheme is also investigated for application at the SLAC NLCTA facility, where we show that the subfemtosecond resolution is sufficient to resolve the temporal structure of the beam used in the echo-enabled free-electron laser. We employ beam simulations to verify the effect for typical Neptune and NLCTA parameter sets and demonstrate the feasibility of the concept.

  17. lightsources.org: An Internet Site for Light SourceCommunication

    SciTech Connect

    Robinson, Art

    2004-10-04

    Research at the world's accelerator- (storage-ring and linac) based light sources is one of the most dynamic and rapidly growing fields of science. It frequently results in direct benefits to society, thereby demonstrating the value of the research with very concrete examples, but this is not widely understood or appreciated outside of the immediate user community. Our growing group of light source communicators from facilities in Europe, Asia, and the Americas, inspired by the Interactions.org Web site created by high-energy (elementary-particle)physics communicators, concluded that a light source community Web site (lightsources.org) would be the best tool for establishing effective collaboration between the communications offices of the world's light sources and to maximize the impact of our efforts. We envision lightsources.org to serve as a one-stop-shopping site for information about all aspects of light sources and the research they make possible. Audiences to be served include science communicators, the press, policymakers, the light source community, the wider scientific community, the science-interested public, and students and educators. Our proposal has been sent to the world's light source facility directors by J. Murray Gibson (APS) and William G. Stirling (ESRF). As a result,light sources.org is now being supported by a growing list of facilities from Europe, North America, and Asia. We hope to launch lightsources.org before the end of 2004.

  18. High-intensity positron microprobe at the Thomas Jefferson National Accelerator Facility

    NASA Astrophysics Data System (ADS)

    Golge, S.; Vlahovic, B.; Wojtsekhowski, B.

    2014-06-01

    We present a conceptual design for a novel continuous wave electron-linac based high-intensity high-brightness slow-positron production source with a projected intensity on the order of 1010 e+/s. Reaching this intensity in our design relies on the transport of positrons (T+ below 600 keV) from the electron-positron pair production converter target to a low-radiation and low-temperature area for moderation in a high-efficiency cryogenic rare gas moderator, solid Ne. This design progressed through Monte Carlo optimizations of: electron/positron beam energies and converter target thickness, transport of the e+ beam from the converter to the moderator, extraction of the e+ beam from the magnetic channel, a synchronized raster system, and moderator efficiency calculations. For the extraction of e+ from the magnetic channel, a magnetic field terminator plug prototype has been built and experimental results on the effectiveness of the prototype are presented. The dissipation of the heat away from the converter target and radiation protection measures are also discussed.

  19. A proposed VUV oscillator-based FEL upgrade at Jefferson Lab

    SciTech Connect

    Benson, S. V.; Douglas, D. R.; Evtushenko, P.; Hannon, F. E.; Hernandez-Garcia, C.; Klopf, J. M.; Legg, R. A.; Neil, G. R.; Shinn, M. D.; Tennant, C. D.; Zhang, S.; Williams, G. P.

    2011-09-20

    Advances in superconducting linac technology offer the possibility of an upgrade of the Jefferson Lab Free Electron Laser (JLab FEL) facility to an oscillator-based VUV-FEL that would produce 6 x 10{sup 12} coherent 100 eV photons per pulse at multi-MHz repetition rates in the fundamental. At present JLab operates a pair of oscillator-based continuous-wave Free Electron Lasers (FELs) as a linac-based next generation light source in the IR and UV, with sub-picosecond pulses up to 75 MHz. Harmonics upwards of 10 eV are produced and the fully coherent nature of the source results in peak and average brightness values that are several orders of magnitude higher than storage rings. The accelerator uses an energy recovered linac design for efficiency of operation. New style superconducting linac cryomodules with higher gradient, combined with a new injector and beam transport system allow the development of the FEL to higher photon energies.

  20. Beam dynamics study of a 30 MeV electron linear accelerator to drive a neutron source

    SciTech Connect

    Kumar, Sandeep; Yang, Haeryong; Kang, Heung-Sik

    2014-02-14

    An experimental neutron facility based on 32 MeV/18.47 kW electron linac has been studied by means of PARMELA simulation code. Beam dynamics study for a traveling wave constant gradient electron accelerator is carried out to reach the preferential operation parameters (E = 30 MeV, P = 18 kW, dE/E < 12.47% for 99% particles). The whole linac comprises mainly E-gun, pre-buncher, buncher, and 2 accelerating columns. A disk-loaded, on-axis-coupled, 2π/3-mode type accelerating rf cavity is considered for this linac. After numerous optimizations of linac parameters, 32 MeV beam energy is obtained at the end of the linac. As high electron energy is required to produce acceptable neutron flux. The final neutron flux is estimated to be 5 × 10{sup 11} n/cm{sup 2}/s/mA. Future development will be the real design of a 30 MeV electron linac based on S band traveling wave.

  1. Initial studies of Bremsstrahlung energy deposition in small-bore superconducting undulator structures in linac environments

    SciTech Connect

    Cremer, T.; Tatchyn, R.

    1995-12-31

    One of the more promising technologies for developing minimal-length insertion devices for linac-driven, single-pass Free Electron Lasers (FELs) operating in the x-ray range is based on the use of superconducting (SC) materials. In recent FEL simulations, for example, a bifilar helical SC device with a 2 cm period and 1.8 T field was found to require a 30 m saturation length for operation at 1.5{Angstrom} on a 15 GeV linac, more than 40% shorter than an alternative hybrid/permanent magnet (hybrid/PM) undulator. AT the same time, however, SC technology is known to present characteristic difficulties for insertion device design, both in engineering detail and in operation. Perhaps the most critical problem, as observed, e.g., by Madey and co-workers in their initial FEL experiments, was the frequent quenching induced by scattered electrons upstream of their (bifilar) device. Postulating that this quenching was precipitated by directly-scattered or bremsstrahlung-induced particle energy deposited into the SC material or into material contiguous with it, the importance of numerical and experimental characterizations of this phenomenon for linac-based, user-facility SC undulator design becomes evident. In this paper we discuss selected prior experimental results and report on initial EGS4 code studies of scattered and bremsstrahlung induced particle energy deposition into SC structures with geometries comparable to a small-bore bifilar helical undulator.

  2. Design and parameter optimization of a small-scale electron-based ADS for radioactive waste transmutation

    NASA Astrophysics Data System (ADS)

    Feizi, H.; Ranjbar, A. H.

    2015-05-01

    This paper presents the design and feasibility of an electron-LINAC-based small-scale system (ADS) for nuclear waste transmutation. FLUKA simulations have been performed to evaluate the photoneutron yield in high- Z metallic targets such as silver, tungsten, lead, tantalum and uranium irradiated by electron beams of 20-200MeV. The parameters involved in the photoneutron production mechanism including electron beam energy, target material and target shape have been investigated in order to obtain maximum photoneutron production. The neutron reflectors of the ADS, in particular, beryllium, lead and beryllium oxide (BeO) with various thicknesses have been studied. The results show that a combination of an internal reflector of Pb with a thickness of 3cm and an external reflector of BeO with a thickness of 10cm improves the fluence rate. The photoneutron energy spectrum, photoneutron fluence distribution and heat deposition in the electron target have also been presented. At incident electron beam energy of 155MeV, a neutron source of ˜ 4.6 × 1010 (n/cm2/s/mA) has been achieved, which is highly applicable for using in nuclear waste transmutation. The designed ADS has the ability to transmute ˜ 1.5 × 1022 (atoms/y/mA). The obtained results are promising and could lead to the development of a small-scale ADS based on electron LINAC for radioactive waste transmutation and for numerous applications when employed as a photoneutron source.

  3. Lightning control system using high power microwave FEL

    SciTech Connect

    Shiho, M.; Watanbe, A.; Kawasaki, S.

    1995-12-31

    A research project for developing a thunder lightning control system using an induction linac based high power microwave free electron laser (FEL) started at JAERI The system will produce weakly ionized plasma rod in the atmosphere by high power microwaves and control a lightning path, away from , e. g., nuclear power stations and rocket launchers. It has been known that about MW/cm{sup 2} power density is enough for the atmospheric breakdown in the microwave region, and which means high power microwave FEL with GW level output power is feasible for atmospheric breakdown, and accordingly is feasible for thunder lightning control tool with making a conductive plasma channel in the atmosphere. From the microwave attenuation consideration in the atmosphere, FEL of 35GHz(0.13dB/km), 90GHz(0.35dB/km), 140GHz(1.7dB/km), and of 270 GHz(4.5dB/km) are the best candidates for the system. Comparing with other proposed lightning control system using visible or ultraviolet laser, the system using microwave has an advantage that microwave suffers smaller attenuation by rain or snow which always exist in the real atmospheric circumstances when lightning occurs.

  4. The Japanese Positron Factory

    NASA Astrophysics Data System (ADS)

    Okada, S.; Sunaga, H.; Kaneko, H.; Takizawa, H.; Kawasuso, A.; Yotsumoto, K.; Tanaka, R.

    1999-06-01

    The Positron Factory has been planned at Japan Atomic Energy Research Institute (JAERI). The factory is expected to produce linac-based monoenergetic positron beams having world-highest intensities of more than 1010e+/sec, which will be applied for R&D of materials science, biotechnology and basic physics & chemistry. In this article, results of the design studies are demonstrated for the following essential components of the facilities: 1) Conceptual design of a high-power electron linac with 100 MeV in beam energy and 100 kW in averaged beam power, 2) Performance tests of the RF window in the high-power klystron and of the electron beam window, 3) Development of a self-driven rotating electron-to-positron converter and the performance tests, 4) Proposal of multi-channel beam generation system for monoenergetic positrons, with a series of moderator assemblies based on a newly developed Monte Carlo simulation and the demonstrative experiment, 5) Proposal of highly efficient moderator structures, 6) Conceptual design of a local shield to suppress the surrounding radiation and activation levels.

  5. The VUV/IR/THz Free Electron Laser Program at Jefferson Lab

    SciTech Connect

    Benson, S V; Boyce, J R; Douglas, D R; Evtushenko, P; Hannon, F E; Hernandez-Garcia, C; Klopf, J M; Neil, G R; Shinn, Michelle D; Tennant, C D; Zhang, S; Williams, G P

    2011-09-01

    Jefferson Lab operates a pair of oscillator-based continuous-wave Free Electron Lasers (FELs) as a linac-based next generation light source with pulse repetition rates up to 75 MHz. The facility uses an energy recovered linac design for efficiency of operation. Recent advances in superconducting technology have been implemented to produce higher acceleration gradients in the linac to produce higher electron beam energies that result in higher photon energies. Thus, while the system originally operated only in the IR, it now covers the photon energy range from the UV to THz, with harmonics upwards of 10 eV with an average spectral flux that is calculated to be 5x1017 photons/sec/0.1%BW. Pulse lengths are in the sub-picosecond regime, and the fully coherent nature of the source, both transversely and longitudinally, results in peak and average brightness values that are several orders of magnitude higher than storage rings. The system provides an R&D test-bed for studies of electron beam dynamics in a regime appropriate for next generation light sources operating at MHz repetition rates.

  6. Beam energy tracking system on Optima XEx high energy ion implanter

    SciTech Connect

    David, Jonathan; Satoh, Shu; Wu Xiangyang; Geary, Cindy; Deluca, James

    2012-11-06

    The Axcelis Optima XEx high energy implanter is an RF linac-based implanter with 12 RF resonators for beam acceleration. Even though each acceleration field is an alternating, sinusoidal RF field, the well known phase-focusing principle produces a beam with a sharp quasi-monoenergetic energy spectrum. A magnetic energy filter after the linac further attenuates the low energy continuum in the energy spectrum often associated with RF acceleration. The final beam energy is a function of the phase and amplitude of the 12 resonators in the linac. When tuning a beam, the magnetic energy filter is set to the desired energy, and each linac parameter is tuned to maximize the transmission through the filter. Once a beam is set up, all the parameters are stored in a recipe, which can be easily tuned and has proven to be quite repeatable. The magnetic field setting of the energy filter selects the beam energy from the RF Linac accelerator, and in-situ verification of beam energy in addition to the magnetic energy filter setting has long been desired. An independent energy tracking system was developed for this purpose, using the existing electrostatic beam scanner as a deflector to construct an in-situ electrostatic energy analyzer. This paper will describe the system and performance of the beam energy tracking system.

  7. Tests of photocathodes for high repetition rate x-ray FELs at the APEX facility at LBNL

    NASA Astrophysics Data System (ADS)

    Sannibale, Fernando; Filippetto, Daniele; Qian, Houjun; Papadopoulos, Christos F.; Wells, Russell; Kramasz, Toby; Padmore, Howard; Feng, Jun; Nasiatka, James; Huang, Ruixuan; Zolotorev, Max; Staples, John W.

    2015-05-01

    After the formidable results of X-ray 4th generation light sources based on free electron lasers around the world, a new revolutionary step is undergoing to extend the FEL performance from the present few hundred Hz to MHz-class repetition rates. In such facilities, temporally equi-spaced pulses will allow for a wide range of previously non-accessible experiments. The Advanced Photo-injector EXperiment (APEX) at the Lawrence Berkeley National Laboratory (LBNL), is devoted to test the capability of a novel scheme electron source, the VHF-Gun, to generate the required electron beam brightness at MHz repetition rates. In linac-based FELs, the ultimate performance in terms of brightness is defined at the injector, and in particular, cathodes play a major role in the game. Part of the APEX program consists in testing high quantum efficiency photocathodes capable to operate at the conditions required by such challenging machines. Results and status of these tests at LBNL are presented.

  8. On the future of BNL user facilities

    SciTech Connect

    Ben-Zvi, I.

    2010-08-01

    The purpose of this document is to portray the emerging technology of high-power high-brightness electron beams. This new technology will impact several fields of science and it is essential that BNL stay abreast of the development. BNL has a relative advantage and vital interest in pursuing this technology that will impact its two major facilities, the NSLS and RHIC. We have a sensible development path towards this critical future technology, in which BNL will gradually acquire a strong basis of Superconducting Radio Frequency (SRF) technology while executing useful projects. The technology of high-power AND high-brightness (HPHB) electron beams is based of the convergence of two extant, but relatively recent technologies: Photoinjectors and superconducting energy-recovering linacs. The HPHB technology presents special opportunities for the development of future BNL user facilities for High-Energy and Nuclear Science (HE-NP) and Basic Energy Science (BES). In HE-NP this technology makes it possible to build high-energy electron cooling for RHIC in the short range and a unique linac-based electron-ion collider (eRHIC). In BES, we can build short pulse, coherent FIR sources and high flux femtosecond hard x-ray sources based on Compton scattering in the short range and, in the longer range, femtosecond, ultra-high brightness synchrotron light sources and, ultimately, an X-ray Free-Electron Laser (FEL).

  9. Design study of the bending sections between harmonic cascade FEL stages

    SciTech Connect

    Wan, Weishi; Corlett, John; Fawley, William; Zholents, A.

    2004-06-30

    The present design of LUX (linac based ultra-fast X-ray facility) includes a harmonic cascade FEL chain to generate coherent EUV and soft X-ray radiation. Four cascade stages, each consisting of two undulators acting as a modulator and a radiator, respectively, are envisioned to produce photons of approximate wavelengths 48 nm, 12 nm, 4 nm and 1 nm. Bending sections may be placed between the modulator and the radiator of each stage to adjust and maintain bunching of the electrons, to separate, in space, photons of different wavelengths and to optimize the use of real estate. In this note, the conceptual design of such a bending section, which may be used at all four stages, is presented. Preliminary tracking results show that it is possible to maintain bunch structure of nm length scale in the presence of errors, provided that there is adequate orbit correction and there are 2 families of trim quads and trim skew quads, respectively, in each bending section.

  10. Microbunching Instability due to Bunch Compression

    SciTech Connect

    Huang, Zhirong; Wu, Juhao; Shaftan, Timur; /Brookhaven

    2005-12-13

    Magnetic bunch compressors are designed to increase the peak current while maintaining the transverse and longitudinal emittances in order to drive a short-wavelength free electron laser (FEL). Recently, several linac-based FEL experiments observe self-developing micro-structures in the longitudinal phase space of electron bunches undergoing strong compression [1-3]. In the mean time, computer simulations of coherent synchrotron radiation (CSR) effects in bunch compressors illustrate that a CSR-driven microbunching instability may significantly amplify small longitudinal density and energy modulations and hence degrade the beam quality [4]. Various theoretical models have since been developed to describe this instability [5-8]. It is also pointed out that the microbunching instability may be driven strongly by the longitudinal space charge (LSC) field [9,10] and by the linac wakefield [11] in the accelerator, leading to a very large overall gain of a two-stage compression system such as found in the Linac Coherent Light Source (LCLS) [12]. This paper reviews theory and simulations of microbunching instability due to bunch compression, the proposed method to suppress its effects for short-wavelength FELs, and experimental characterizations of beam modulations in linear accelerators. A related topic of interests is microbunching instability in storage rings, which has been reported in the previous ICFA beam dynamics newsletter No. 35 (http://wwwbd. fnal.gov/icfabd/Newsletter35.pdf).

  11. Study of Strangeness Photoproduction on the Neutron in the Threshold Region

    NASA Astrophysics Data System (ADS)

    Kanda, Hiroki; Beckford, Brian; Fujibayashi, Takeji; Fujii, Takao; Fujii, Yu; Futatsukawa, Kenta; Gogami, Toshiyuki; Han, Yun-Cheng; Hashimoto, Osamu; Hirose, Kentaro; Honda, Ryotaro; Hosomi, Kenji; Iguchi, Alan; Ishikawa, Takatsugu; Kaneko, Yusuke; Kaneta, Masashi; Kasai, Yuma; Kawama, Daisuke; Kawasaki, Taito; Kimura, Chigusa; Kiyokawa, Shogo; Koike, Takeshi; Maeda, Kazushige; Maruta, Tomofumi; Maruyama, Nayuta; Matsubara, Masao; Miwa, Koji; Miyagi, Yohei; Nagao, Sho; Nakamura, Satoshi N.; Okuyama, Akira; Suzuki, Kotaku; Tamae, Tadaaki; Tamura, Hirokazu; Terada, Nobuhiro; Tsukada, Kyo; Wang, Tie-Shang; Yamamoto, Fumiya; Yamamoto, Takeshi O.; Yamazaki, Hirohito

    2013-08-01

    Photoproduction of the neutral kaon on the deuteron has been investigated at the Research Center for Electron Photon Science, Tohoku University. We constructed the Neutral Kaon Spectrometer-2 for the detection of charged particles from the decay of the neutral kaon and the hyperon. We obtained a momentum distribution of K 0 with the inclusive measurement. It was consistent with the previous measurement. The total cross section of γ + d → K 0 + Λ + p was estimated from the measured integral cross section of γ + d → Λ + X. The total cross section with respect to the photon energy was compared with the theoretical calculations. It favored the Saclay-Lyon A model calculation with the ratio of the neutral to charged coupling constants of the axial-vector meson, K 1, as ~ -1.5. The energy dependence and the magnitude of the total cross section were similar to the total cross section of γ + p → K + Λ.

  12. Measurement of Charged Pion Photoproduction at ELPH

    NASA Astrophysics Data System (ADS)

    Kanda, Hiroki; Beckford, Brian; Fujibayashi, Takeji; Fujii, Takao; Fujii, Yu; Futatsukawa, Kenta; Gogami, Toshiyuki; Han, Yun-Cheng; Hashimoto, Osamu; Hirose, Kentaro; Hosomi, Kenji; Honda, Ryotaro; Iguchi, Alan; Ishikawa, Takatsugu; Kaneta, Masashi; Kaneko, Yusuke; Kasai, Yuma; Kawasaki, Taito; Kimura, Chigusa; Kiyokawa, Shogo; Koike, Takeshi; Maeda, Kazushige; Maruyama, Nayuta; Matsubara, Masao; Miwa, Koji; Miyagi, Yohei; Nagao, Sho; Nakamura, Satoshi N.; Nishizawa, Takashi; Okuyama, Akira; Shimizu, Hajime; Suzuki, Kotaku; Tamae, Tadaaki; Tamura, Hirokazu; Tsukada, Kyo; Terada, Nobu; Ukai, Mifuyu; Wang, Tie-Shan; Yamamoto, Fumiya; Yamazaki, Hirohito

    We investigated the charged pion photoproductions on the deuteron in the photon energy region of 0.65 to 1.1 GeV at Research Center for Electron Photon Science, Tohoku University. The objective is to explore the π+π- photoproduction process which dominates at Eγ > 0.8 GeV. We measured the charged particles from the photoreaction on the deuteron with the Neutral Kaon Spectrometer-2 (NKS2). The analyses both for quasi-free and non-quasi-free processes are underway. As one of the non-quasi-free processes, γd → π+π-d was separated by requiring π+, π- and d. The relative yield and the π+π- invariant mass spectra are presented. We are also proceeding with the development of the new photon tagger to be ready in 2014.

  13. Bose-Einstein correlations between two neutral pions from photoproduction below 1.2 GeV

    NASA Astrophysics Data System (ADS)

    He, Qinghua; Hashimoto, Ryo; Ishikawa, Takatsugu; Masumoto, Shinichi; Miyabe, Manabu; Muramatsu, Norihito; Shimizu, Hajime; Tajima, Yasuhisa; Tsuchikawa, Yusuke; Yamazaki, Hirohito; Yamazaki, Ryuji; Forest Collaboration

    2014-09-01

    For the first time, we studied the space-time properties of the excited nucleons in the non-perturbative QCD region, via Bose-Einstein correlations (BEC) between two neutral pions from photoproduction off the proton/deuteron at incident photon energies below 1.2 GeV. In order to measure the Bose-Einstein correlations of two pions, an event mixing technique was developed and proved to be effective. The experiment was carried out at the Research Center for Electron Photon Science (ELPH) at Tohoku University. A 4 π electromagnetic calorimeter complex, named FOREST, was employed to detect neutral pions decaying into photons as well as some charged particles in the final state. In this work, we present the results of the spatial extension of the reaction region obtained from the BEC analysis. In addition, the BEC analysis provides useful information about the underlying mechanism of double neutral pion photoproduction. Preliminary results related to this study will be given.

  14. Photoproduction of K+Λ and K0Λ on Deuteron

    NASA Astrophysics Data System (ADS)

    Fujii, Takao; Beckford, Brian; Fujii, Yu; Hashimoto, Osamu; Ishikawa, Takatsugu; Kanda, Hiroki; Kaneta, Masashi; Kimura, Chigusa; Koike, Takeshi; Maeda, Kazushige; Miwa, Koji; Nakamura, Satoshi N.; Tamura, Hirokazu; Yamamoto, Fumiya; Yamazaki, Hirohito

    We carried out a measurement of γd → K+Λn and γd → K0Λp with the 1 GeV region tagged photon beams at Research Center for Electron Photon Science, Tohoku University. Both reactions were simultaneously recorded in data files, extracted by identification of three charged particles, and separated by kinematical analyses. In the measurement of γd → K+Λn, identification of π-, p, and K+ and kinematical reconstruction enabled kinematically complete measurement of the reaction and its center-of-mass kinematics can be reconstructed. We finished the data analysis of γd → K+Λn process up to 40% of the total data. Further analysis is underway.

  15. Two-photon absorption of few-electron heavy ions

    SciTech Connect

    Surzhykov, A.; Indelicato, P.; Santos, J. P.; Amaro, P.; Fritzsche, S.

    2011-08-15

    The two-photon absorption of few-electron ions has been studied by using second-order perturbation theory and Dirac's relativistic equation. Within this framework, the general expressions for the excitation cross sections and rates are derived including a full account of the higher-order multipole terms in the expansion of the electron-photon interaction. While these expressions can be applied to any ion, independent of its particular shell structure, detailed computations are carried out for the two-photon absorption of hydrogen-, helium-, and berylliumlike ions and are compared with the available theoretical and experimental data. The importance of relativistic and nondipole effects in the analysis and computation of induced two-photon transitions is pointed out. Moreover, we discuss the potential of these transitions for atomic parity-violation studies in the high-Z domain.

  16. Angular correlations in the two-photon decay of heliumlike heavy ions

    SciTech Connect

    Surzhykov, A.; Fratini, F.; Volotka, A.; Santos, J. P.; Indelicato, P.; Plunien, G.; Stoehlker, Th.; Fritzsche, S.

    2010-04-15

    The two-photon decay of heavy, helium-like ions is investigated based on second-order perturbation theory and Dirac's relativistic equation. Special attention has been paid to the angular emission of the two photons (i.e., how the angular correlation function depends on the shell structure of the ions in their initial and final states). Moreover, the effects from the (electric and magnetic) nondipole terms in the expansion of the electron-photon interaction are discussed. Detailed calculations have been carried out for the two-photon decay of the 1s2s {sup 1}S{sub 0}, 1s2s {sup 3}S{sub 1}, and 1s2p {sup 3}P{sub 0} states of helium-like Xe{sup 52+}, Au{sup 77+}, and U{sup 90+} ions.

  17. Cobalt-60 simulation of LOCA (loss of coolant accident) radiation effects

    SciTech Connect

    Buckalew, W.H.

    1989-07-01

    The consequences of simulating nuclear reactor loss of coolant accident (LOCA) radiation effects with Cobalt-60 gamma ray irradiators have been investigated. Based on radiation induced damage in polymer base materials, it was demonstrated that electron/photon induced radiation damage could be related on the basis of average absorbed radiation dose. This result was used to estimate the relative effectiveness of the mixed beta/gamma LOCA and Cobalt-60 radiation environments to damage both bare and jacketed polymer base electrical insulation materials. From the results obtained, it is concluded that present simulation techniques are a conservative method for simulating LOCA radiation effects and that the practices have probably substantially overstressed both bare and jacketed materials during qualification testing. 9 refs., 8 figs., 5 tabs.

  18. Low-cost fabrication technologies for nanostructures: state-of-the-art and potential

    NASA Astrophysics Data System (ADS)

    Santos, A.; Deen, M. J.; Marsal, L. F.

    2015-01-01

    In the last decade, some low-cost nanofabrication technologies used in several disciplines of nanotechnology have demonstrated promising results in terms of versatility and scalability for producing innovative nanostructures. While conventional nanofabrication technologies such as photolithography are and will be an important part of nanofabrication, some low-cost nanofabrication technologies have demonstrated outstanding capabilities for large-scale production, providing high throughputs with acceptable resolution and broad versatility. Some of these nanotechnological approaches are reviewed in this article, providing information about the fundamentals, limitations and potential future developments towards nanofabrication processes capable of producing a broad range of nanostructures. Furthermore, in many cases, these low-cost nanofabrication approaches can be combined with traditional nanofabrication technologies. This combination is considered a promising way of generating innovative nanostructures suitable for a broad range of applications such as in opto-electronics, nano-electronics, photonics, sensing, biotechnology or medicine.

  19. Characterization of rare-earth-doped nanophosphors for photodynamic therapy excited by clinical ionizing radiation beams

    NASA Astrophysics Data System (ADS)

    Darafsheh, Arash; Najmr, Stan; Paik, Taejong; Tenuto, Michael E.; Murray, Christopher B.; Finlay, Jarod C.; Friedberg, Joseph S.

    2015-03-01

    We investigated the optical properties of novel terbium (Tb3+)-doped nanophosphors with various host compounds irradiated by clinical electron, photon, and proton beams for their potential as optical probes. The emission spectra of nanophosphors embedded in tissue-mimicking phantoms were collected by an optical fiber connected to a CCD-coupled spectrograph while the samples were irradiated with electron and photon beams generated by a medical linear accelerator and proton beams generated by a clinical cyclotron. We characterized the luminescence of such nanophosphors as a function of the beam energy and observed a dose dependency of the luminescence signal. We demonstrated x-ray luminescence, cathodoluminescence, and ionoluminescence of the nanophosphors in clinical ionizing radiation fields, which indicates their potential as downconverters of high-energy radiation into visible light.

  20. The molecular photo-cell: quantum transport and energy conversion at strong non-equilibrium.

    PubMed

    Ajisaka, Shigeru; Žunkovič, Bojan; Dubi, Yonatan

    2015-01-01

    The molecular photo-cell is a single molecular donor-acceptor complex attached to electrodes and subject to external illumination. Besides the obvious relevance to molecular photo-voltaics, the molecular photo-cell is of interest being a paradigmatic example for a system that inherently operates in out-of-equilibrium conditions and typically far from the linear response regime. Moreover, this system includes electrons, phonons and photons, and environments which induce coherent and incoherent processes, making it a challenging system to address theoretically. Here, using an open quantum systems approach, we analyze the non-equilibrium transport properties and energy conversion performance of a molecular photo-cell, including both coherent and incoherent processes and treating electrons, photons, and phonons on an equal footing. We find that both the non-equilibrium conditions and decoherence play a crucial role in determining the performance of the photovoltaic conversion and the optimal energy configuration of the molecular system. PMID:25660494

  1. Facile strain analysis of largely bending films by a surface-labelled grating method

    NASA Astrophysics Data System (ADS)

    Akamatsu, Norihisa; Tashiro, Wataru; Saito, Keisuke; Mamiya, Jun-Ichi; Kinoshita, Motoi; Ikeda, Tomiki; Takeya, Jun; Fujikawa, Shigenori; Priimagi, Arri; Shishido, Atsushi

    2014-06-01

    Mechanical properties of flexible films, for example surface strain of largely bending films, are key to design of stretchable electronic devices, wearable biointegrated devices, and soft microactuators/robots. However, existing methods are mainly based on strain-gauge measurements that require miniaturized array sensors, lead wires, and complicated calibrations. Here we introduce a facile method, based on surface-labelled gratings, for two-dimensional evaluation of surface strains in largely bending films. With this technique, we demonstrate that soft-matter mechanics can be distinct from the mechanics of hard materials. In particular, liquid-crystalline elastomers may undergo unconventional bending in three dimensions, in which both the inner and outer surfaces of the bending film are compressed. We also show that this method can be applied to amorphous elastomeric films, which highlights the general importance of this new mechanical evaluation tool in designing soft-matter-based electronic/photonic as well as biointegrated materials.

  2. Elucidating Quantum Confinement in Graphene Oxide Dots Based On Excitation-Wavelength-Independent Photoluminescence.

    PubMed

    Yeh, Te-Fu; Huang, Wei-Lun; Chung, Chung-Jen; Chiang, I-Ting; Chen, Liang-Che; Chang, Hsin-Yu; Su, Wu-Chou; Cheng, Ching; Chen, Shean-Jen; Teng, Hsisheng

    2016-06-01

    Investigating quantum confinement in graphene under ambient conditions remains a challenge. In this study, we present graphene oxide quantum dots (GOQDs) that show excitation-wavelength-independent photoluminescence. The luminescence color varies from orange-red to blue as the GOQD size is reduced from 8 to 1 nm. The photoluminescence of each GOQD specimen is associated with electron transitions from the antibonding π (π*) to oxygen nonbonding (n-state) orbitals. The observed quantum confinement is ascribed to a size change in the sp(2) domains, which leads to a change in the π*-π gap; the n-state levels remain unaffected by the size change. The electronic properties and mechanisms involved in quantum-confined photoluminescence can serve as the foundation for the application of oxygenated graphene in electronics, photonics, and biology. PMID:27192445

  3. Nanobonding: A key technology for emerging applications in health and environmental sciences

    NASA Astrophysics Data System (ADS)

    Howlader, Matiar M. R.; Deen, M. Jamal; Suga, Tadatomo

    2015-03-01

    In this paper, surface-activation-based nanobonding technology and its applications are described. This bonding technology allows for the integration of electronic, photonic, fluidic and mechanical components into small form-factor systems for emerging sensing and imaging applications in health and environmental sciences. Here, we describe four different nanobonding techniques that have been used for the integration of various substrates — silicon, gallium arsenide, glass, and gold. We use these substrates to create electronic (silicon), photonic (silicon and gallium arsenide), microelectromechanical (glass and silicon), and fluidic (silicon and glass) components for biosensing and bioimaging systems being developed. Our nanobonding technologies provide void-free, strong, and nanometer scale bonding at room temperature or at low temperatures (<200 °C), and do not require chemicals, adhesives, or high external pressure. The interfaces of the nanobonded materials in ultra-high vacuum and in air correspond to covalent bonds, and hydrogen or hydroxyl bonds, respectively.

  4. RLE (Research Laboratory of Electronics)

    NASA Astrophysics Data System (ADS)

    Allen, J.

    1983-01-01

    Topics being studied at the Massachusetts Institute of Technology's Research Laboratory of Electronics are discussed. Among the topics discussed are: Molecule Microscopy; Semiconductor Surface Studies; Atomic Resonance and Scattering; Reaction Dynamics at Semiconductor Surfaces; X-Ray Diffuse Scattering; Phase Transitions in Chemisorbed Systems; Optics and Quantum Electronics; Photonics; Optical Spectroscopy of Disordered Materials and X-ray Scattering from Surfaces; Infrared Nonlinear Optics; Quantum Optics and Electronics; Microwave and Millimeter Wave Techniques; Microwave and Quantum Magnetics; Radio Astronomy; Electromagnetic Wave Theory and Remote Sensing; Electronic Properties of Amorphous Silicon Dioxide; Photon Correlation Spectroscopy and Applications; Submicron Structures Fabrication and Research; Plasma Dynamics; Optical Propagation and Communication; Digital Signal Processing Group; Speech Communication; Linguistics; Custom Integrated Circuits; Communications Biophysics; and Physiology.

  5. 2D and 3D heterogeneous photonic integrated circuits

    NASA Astrophysics Data System (ADS)

    Yoo, S. J. Ben

    2014-03-01

    Exponential increases in the amount of data that need to be sensed, communicated, and processed are continuing to drive the complexity of our computing, networking, and sensing systems. High degrees of integration is essential in scalable, practical, and cost-effective microsystems. In electronics, high-density 2D integration has naturally evolved towards 3D integration by stacking of memory and processor chips with through-silicon-vias. In photonics, too, we anticipate highdegrees of 3D integration of photonic components to become a prevailing method in realizing future microsystems for information and communication technologies. However, compared to electronics, photonic 3D integration face a number of challenges. This paper will review two methods of 3D photonic integration --- fs laser inscription and layer stacking, and discuss applications and future prospects.

  6. Measurement of the photon structure function F2γ at low x

    NASA Astrophysics Data System (ADS)

    OPAL Collaboration; Ackerstaff, K.; Alexander, G.; Allison, J.; Altekamp, N.; Anderson, K. J.; Anderson, S.; Arcelli, S.; Asai, S.; Axen, D.; Azuelos, G.; Ball, A. H.; Barberio, E.; Barillari, T.; Barlow, R. J.; Bartoldus, R.; Batley, J. R.; Baumann, S.; Bechtluft, J.; Beeston, C.; Behnke, T.; Bell, A. N.; Bell, K. W.; Bella, G.; Bentvelsen, S.; Bethke, S.; Biebel, O.; Biguzzi, A.; Bird, S. D.; Blobel, V.; Bloodworth, I. J.; Bloomer, J. E.; Bobinski, M.; Bock, P.; Bonacorsi, D.; Boutemeur, M.; Bouwens, B. T.; Braibant, S.; Brigliadori, L.; Brown, R. M.; Burckhart, H. J.; Burgard, C.; Bürgin, R.; Capiluppi, P.; Carnegie, R. K.; Carter, A. A.; Carter, J. R.; Chang, C. Y.; Charlton, D. G.; Chrisman, D.; Clarke, P. E. L.; Cohen, I.; Conboy, J. E.; Cooke, O. C.; Cuffiani, M.; Dado, S.; Dallapiccola, C.; Dallavalle, G. M.; Davies, R.; de Jong, S.; del Pozo, L. A.; Desch, K.; Dienes, B.; Dixit, M. S.; Do Couto e Silva, E.; Doucet, M.; Duchovni, E.; Duckeck, G.; Duerdoth, I. P.; Eatough, D.; Edwards, J. E. G.; Estabrooks, P. G.; Evans, H. G.; Evans, M.; Fabbri, F.; Fanti, M.; Faust, A. A.; Fiedler, F.; Fierro, M.; Fischer, H. M.; Fleck, I.; Folman, R.; Fong, D. G.; Foucher, M.; Fürtjes, A.; Futyan, D. I.; Gagnon, P.; Gary, J. W.; Gascon, J.; Gascon-Shotkin, S. M.; Geddes, N. I.; Geich-Gimbel, C.; Geralis, T.; Giacomelli, G.; Giacomelli, P.; Giacomelli, R.; Gibson, V.; Gibson, W. R.; Gingrich, D. M.; Glenzinski, D.; Goldberg, J.; Goodrick, M. J.; Gorn, W.; Grandi, C.; Gross, E.; Grunhaus, J.; Gruwé, M.; Hajdu, C.; Hanson, G. G.; Hansroul, M.; Hapke, M.; Hargrove, C. K.; Hart, P. A.; Hartmann, C.; Hauschild, M.; Hawkes, C. M.; Hawkings, R.; Hemingway, R. J.; Herndon, M.; Herten, G.; Heuer, R. D.; Hildreth, M. D.; Hill, J. C.; Hillier, S. J.; Hobson, P. R.; Homer, R. J.; Honma, A. K.; Horváth, D.; Hossain, K. R.; Howard, R.; Hüntemeyer, P.; Hutchcroft, D. E.; Igo-Kemenes, P.; Imrie, D. C.; Ingram, M. R.; Ishii, K.; Jawahery, A.; Jeffreys, P. W.; Jeremie, H.; Jimack, M.; Joly, A.; Jones, C. R.; Jones, G.; Jones, M.; Jost, U.; Jovanovic, P.; Junk, T. R.; Karlen, D.; Kartvelishvili, V.; Kawagoe, K.; Kawamoto, T.; Kayal, P. I.; Keeler, R. K.; Kellogg, R. G.; Kennedy, B. W.; Kirk, J.; Klier, A.; Kluth, S.; Kobayashi, T.; Kobel, M.; Koetke, D. S.; Kokott, T. P.; Kolrep, M.; Komamiya, S.; Kress, T.; Krieger, P.; von Krogh, J.; Kyberd, P.; Lafferty, G. D.; Lahmann, R.; Lai, W. P.; Lanske, D.; Lauber, J.; Lautenschlager, S. R.; Layter, J. G.; Lazic, D.; Lee, A. M.; Lefebvre, E.; Lellouch, D.; Letts, J.; Levinson, L.; Lloyd, S. L.; Loebinger, F. K.; Long, G. D.; Losty, M. J.; Ludwig, J.; Macchiolo, A.; MacPherson, A.; Mannelli, M.; Marcellini, S.; Markus, C.; Martin, A. J.; Martin, J. P.; Martinez, G.; Mashimo, T.; Mättig, P.; McDonald, W. J.; McKenna, J.; McKigney, E. A.; McMahon, T. J.; McPherson, R. A.; Meijers, F.; Menke, S.; Merritt, F. S.; Mes, H.; Meyer, J.; Michelini, A.; Mikenberg, G.; Miller, D. J.; Mincer, A.; Mir, R.; Mohr, W.; Montanari, A.; Mori, T.; Morii, M.; Müller, U.; Mihara, S.; Nagai, K.; Nakamura, I.; Neal, H. A.; Nellen, B.; Nisius, R.; O'Neale, S. W.; Oakham, F. G.; Odorici, F.; Ogren, H. O.; Oh, A.; Oldershaw, N. J.; Oreglia, M. J.; Orito, S.; Pálinkás, J.; Pásztor, G.; Pater, J. R.; Patrick, G. N.; Patt, J.; Pearce, M. J.; Perez-Ochoa, R.; Petzold, S.; Pfeifenschneider, P.; Pilcher, J. E.; Pinfold, J.; Plane, D. E.; Poffenberger, P.; Poli, B.; Posthaus, A.; Rees, D. L.; Rigby, D.; Robertson, S.; Robins, S. A.; Rodning, N.; Roney, J. M.; Rooke, A.; Ros, E.; Rossi, A. M.; Routenburg, P.; Rozen, Y.; Runge, K.; Runolfsson, O.; Ruppel, U.; Rust, D. R.; Rylko, R.; Sachs, K.; Saeki, T.; Sarkisyan, E. K. G.; Sbarra, C.; Schaile, A. D.; Schaile, O.; Scharf, F.; Scharff-Hansen, P.; Schenk, P.; Schieck, J.; Schleper, P.; Schmitt, B.; Schmitt, S.; Schöning, A.; Schröder, M.; Schultz-Coulon, H. C.; Schumacher, M.; Schwick, C.; Scott, W. G.; Shears, T. G.; Shen, B. C.; Shepherd-Themistocleous, C. H.; Sherwood, P.; Siroli, G. P.; Sittler, A.; Skillman, A.; Skuja, A.; Smith, A. M.; Snow, G. A.; Sobie, R.; Söldner-Rembold, S.; Springer, R. W.; Sproston, M.; Stephens, K.; Steuerer, J.; Stockhausen, B.; Stoll, K.; Strom, D.; Szymanski, P.; Tafirout, R.; Talbot, S. D.; Tanaka, S.; Taras, P.; Tarem, S.; Teuscher, R.; Thiergen, M.; Thomson, M. A.; von Törne, E.; Towers, S.; Trigger, I.; Trócsányi, Z.; Tsur, E.; Turcot, A. S.; Turner-Watson, M. F.; Utzat, P.; van Kooten, R.; Verzocchi, M.; Vikas, P.; Vokurka, E. H.; Voss, H.; Wäckerle, F.; Wagner, A.; Ward, C. P.; Ward, D. R.; Watkins, P. M.; Watson, A. T.; Watson, N. K.; Wells, P. S.; Wermes, N.; White, J. S.; Wilkens, B.; Wilson, G. W.; Wilson, J. A.; Wolf, G.; Wyatt, T. R.; Yamashita, S.; Yekutieli, G.; Zacek, V.; Zer-Zion, D.

    1997-10-01

    Deep inelastic electron-photon scattering is studied using e+e- data collected by the OPAL detector at centre-of-mass energies sqrt(see)~MZ0. The photon structure function F2γ(x,Q2) is explored in a Q2 range of 1.1 to 6.6 GeV2 at lower x values than ever before. To probe this kinematic region events are selected with a beam electron scattered into one of the OPAL luminosity calorimeters at scattering angles between 27 and 55 mrad. A measurement is presented of the photon structure function F2γ(x,Q2) at =1.86 GeV2 and 3.76 GeV2 in five logarithmic x bins from 0.0025 to 0.2.

  7. Parametric constraints in multi-beam interference

    NASA Astrophysics Data System (ADS)

    Burrow, Guy M.; Gaylord, Thomas K.

    2012-10-01

    Multi-beam interference (MBI) represents a method of producing one-, two-, and three-dimensional submicron periodic optical-intensity distributions for applications including micro- and nano-electronics, photonic crystals, metamaterial, biomedical structures, optical trapping, and numerous other subwavelength structures. Accordingly, numerous optical configurations have been developed to implement MBI. However, these configurations typically provide limited ability to condition the key parameters of each interfering beam. Constraints on individual beam amplitudes and polarizations are systematically considered to understand their effects on lithographically useful MBI periodic patterning possibilities. A method for analyzing parametric constraints is presented and used to compare the optimized optical-intensity distributions for representative constrained systems. Case studies are presented for both square and hexagonal-lattices produced via three-beam interference. Results demonstrate that constraints on individual-beam polarizations significantly impact patterning possibilities and must be included in the systematic design of an MBI system.

  8. Measurement of organic/polymer material by phase modulation ellipsometry

    NASA Astrophysics Data System (ADS)

    Ji, Yong; Teboul, Eric; Kramer, Alan R.

    2004-06-01

    Due to they can be tailored to provide a wide range of physical properties and their easiness of processing and fabrication, polymeric materials have found widespread use in the manufacture of microwave, electronics, photonics and bio-tech systems. This paper presents the basic principle of phase modulation spectroscopic ellipsometer (PMSE) and its advantages over other ellipsometry in measuring polymer film. Used for thin film measurements ultra-thin dielectric, meal film and organic film, the PMSE technique is now used over a wide spectral range from the vacuum ultraviolet to the mid infrared. Film thickness ranging from Angstrom up to 50um can be measured by PMSE. Applications of PMSE on measurement and characterization of polymer/organic material are given in the paper.

  9. Piezoelectric properties of diphenylalanine microtubes prepared from the solution

    NASA Astrophysics Data System (ADS)

    Vasilev, Semen; Zelenovskiy, Pavel; Vasileva, Daria; Nuraeva, Alla; Shur, Vladimir Ya.; Kholkin, Andrei L.

    2016-06-01

    Biomimetic self-assembling peptides form a variety of structures that can be used for the fabrication of functional devices. We are witnessing the emergence of a new era of bionanotechnology that opens up new possibilities for novel electronic, photonic and energy functionalities based on supramolecular green and lightweight structures. In this work, we study the emergent piezoelectric properties of linear dipeptide diphenylalanine (FF) that can self-assemble in the shape of microtubes. The matrix of piezoelectric coefficients is derived for the first time based on the hexagonal symmetry of FF structures and different configurations of the tubes are tested by the advanced Piezoresponse Force Microscopy (PFM). Strong piezoelectric anisotropy of piezoelectric coefficients is explained by the self-assembled structure of FF peptides. Possible applications of piezoelectric microtubes in functional devices are discussed.

  10. Effect of electron divergence in air gaps on the measurement of the energy of cascades in emulsion chambers

    NASA Technical Reports Server (NTRS)

    Apanasenko, A. V.; Baradzey, L. T.; Kanevskaya, Y. A.; Smorodin, Y. A.

    1975-01-01

    The effect of an increase in electron density in the vicinity of the cascade axis caused by an avalanche passing through the gap between lead filters of the emulsion chamber was investigated experimentally. Optical densities were measured in three X-ray films spaced at 400, 800 and 1200 micrometer from the filter surface having a thickness of 6 cascade units. The optical densities of blackening spots caused by electron photon cascades of 1 to 2, 2 to 7 and greater than 7 BeV energies were measured. The results prove the presence of a gap between the filter and the nuclear emulsion which results in the underestimation of energy by several tenths of a percent.

  11. An investigation of nonuniform dose deposition from an electron beam

    NASA Astrophysics Data System (ADS)

    Lilley, William; Luu, Kieu X.

    1994-08-01

    In a search for an explanation of nonuniform electron-beam dose deposition, the integrated tiger series (ITS) of coupled electron/photon Monte Carlo transport codes was used to calculate energy deposition in the package materials of an application-specific integrated circuit (ASIC) while the thicknesses of some of the materials were varied. The thicknesses of three materials that were in the path of an electron-beam pulse were varied independently so that analysis could determine how the radiation dose measurements using thermoluminescent dosimeters (TLD's) would be affected. The three materials were chosen because they could vary during insertion of the die into the package or during the process of taking dose measurements. The materials were aluminum, HIPEC (a plastic), and silver epoxy. The calculations showed that with very small variations in thickness, the silver epoxy had a large effect on the dose uniformity over the area of the die.

  12. Secondary ion emission from V and Al surfaces under keV light ion on bombardment

    NASA Astrophysics Data System (ADS)

    Blauner, Patricia G.; Weller, Martha R.; Kaurin, Michael G.; Weller, Robert A.

    1986-03-01

    Positive secondary ion mass spectra have been measured for oxidized polycrystalline V and Al targets bombarded by H +, H 2+, He + and Ar + ions with beam energies ranging from 25 keV to 275 keV. An enhancement in the relative yield of positive ions of electronegative surface constituents, in particular O + is observed under light ion bombardment. Metallic ion intensities were found to decrease with increasing primary beam energy in proportion to the estimated total sputtering yields for these targets and beams. In contrast, the O + secondary ion intensities were independent of primary beam energy. This behavior is similar to that observed previously with heavy ions of comparable velocities. In addition, for the projectiles and targets used in these measurements, no energy thresholds or collective effects were observed in the emission of any positive ion. Published data on secondary ion emission resulting from electron, photon, and heavy ion bombardment are compared with these results.

  13. Fluorescence of colloidal PbSe/PbS QDs in NIR luminescent solar concentrators.

    PubMed

    Aeberhard, Urs; Vaxenburg, Roman; Lifshitz, Efrat; Tomić, Stanko

    2012-12-21

    For applications in luminescent solar concentrators harvesting subgap photons, either via direct irradiation of solar cells with optimized band gap or via sensitization of an up-conversion process, exact knowledge and tunability of both the spectral shape and the intensity of the emission are of paramount importance. In this work, we investigate theoretically the photoluminescence spectra of colloidal core-shell PbSe/PbS QDs with type II alignments in the valence band. The method builds on a steady-state formulation of the non-equilibrium Greens function theory for a microscopic system of coupled electrons, photons and phonons interfaced with electronic structure calculations based on a k·p model for PbSe/PbS core-shell QDs. The resulting output spectral density of photons in a realistic QD ensemble is obtained via the renormalization of the incident spectrum according to the polarization of the system. PMID:23080206

  14. Boltzmann-Fokker-Planck calculations using standard discrete-ordinates codes

    SciTech Connect

    Morel, J.E.

    1987-01-01

    The Boltzmann-Fokker-Planck (BFP) equation can be used to describe both neutral and charged-particle transport. Over the past several years, the author and several collaborators have developed methods for representing Fokker-Planck operators with standard multigroup-Legendre cross-section data. When these data are input to a standard S/sub n/ code such as ONETRAN, the code actually solves the Boltzmann-Fokker-Planck equation rather than the Boltzmann equation. This is achieved wihout any modification to the S/sub n/ codes. Because BFP calculations can be more demanding from a numerical viewpoint than standard neutronics calculations, we have found it useful to implement new quadrature methods ad convergence acceleration methods in the standard discrete-ordinates code, ONETRAN. We discuss our BFP cross-section representation techniques, our improved quadrature and acceleration techniques, and present results from BFP coupled electron-photon transport calculations performed with ONETRAN. 19 refs., 7 figs.

  15. Optical responses of a metal with sub-nm gaps.

    PubMed

    Park, Sang Jun; Kim, Tae Yun; Park, Cheol-Hwan; Kim, Dai-Sik

    2016-01-01

    If the size of a metallic structure is reduced to be comparable to or even smaller than the typical quantum-mechanical lengths such as the Fermi wavelength or Thomas-Fermi wavelength, the electronic structure and optical responses are modulated by quantum effects. Here, we calculate the optical responses of a metal with sub-nm gaps using the eigenstates obtained from an effective-mass quantum theory. According to our simulation, the dielectric responses can be significantly modified by tuning the inter-gap distances. Remarkably, sub-nm gaps occupying a 0.3% volumetric fraction can elongate the penetration depth by an order of magnitude in the terahertz regime. We find that the detailed dependences of electron-photon interaction matrix elements on the involved electronic wavefunctions play an important role in the optical responses. The results draw our attention to these recently fabricated systems. PMID:26964884

  16. A fast profile monitor with scintillating fiber hodoscopes for high-intensity photon beams

    NASA Astrophysics Data System (ADS)

    Ishikawa, T.; Fujimura, H.; Hamano, H.; Hashimoto, R.; Honda, Y.; Ishida, T.; Kaida, S.; Kanda, H.; Kido, S.; Matsumura, Y.; Miyabe, M.; Mizutani, K.; Nagasawa, I.; Nakamura, A.; Nanbu, K.; Nawa, K.; Ogushi, S.; Shibasaki, Y.; Shimizu, H.; Sugai, H.; Suzuki, K.; Takahashi, K.; Takahashi, S.; Taniguchi, Y.; Tokiyasu, A. O.; Tsuchikawa, Y.; Yamazaki, H.

    2016-03-01

    A fast beam-profile monitor has been developed for high-energy photon beamlines at the Research Center for Electron Photon Science, Tohoku University. The position of the photon converted into an electron-positron pair in a 0.5 mm-thick aluminum plate is measured with two hodoscopes made of scintillating fibers with cross-sections of 3 × 3mm2. Events in which charged particles are produced upstream are rejected with a charge veto plastic scintillator placed in front of the plate, and pair-production events are identified with a trigger plastic scintillator placed behind the plate. The position is determined by a developed logic module with a field-programmable gate array. The dead time for processing an event is 35 ns, and a high data acquisition efficiency (~ 100 %) can be achieved with this monitor for high-intensity photon beams corresponding to 20 MHz tagging signals.

  17. Study of some superconducting and magnetic materials on high T sub c oxide superconductors

    NASA Technical Reports Server (NTRS)

    Wu, M. K.

    1987-01-01

    On the basis of existing data it appears that the high-temperature superconductivity above 77 K reported here, occurs only in compound systems consisting of a phase other than the K2NiF4 phase. A narrow superconducting transition was obtained with T sub c0 = 98 K and T sub c1 = 94 K in Y-Ba-Cu-O (YBCO). Preliminary results indicate that YBCO is rather different from the layered LaBCO, LaSCO, and LaCCO. While electron-photon interaction cannot be absent from this compound system, nonconventional enhanced superconducting interactions due to interfaces, Resonating Valence Bond (RVB) states, or even a superconducting state beyond the BCS framework, may be required to account for the high T sub c in YBCO. It is believed that study of the possible subtle correlation between magnetism and superconductivity will definitely provide important insight into the superconducting mechanism in YBCO and other oxides.

  18. A general search for new phenomena in ep scattering at HERA

    NASA Astrophysics Data System (ADS)

    Aktas, A.; Andreev, V.; Anthonis, T.; Asmone, A.; Babaev, A.; Backovic, S.; Bähr, J.; Baranov, P.; Barrelet, E.; Bartel, W.; Baumgartner, S.; Becker, J.; Beckingham, M.; Behnke, O.; Behrendt, O.; Belousov, A.; Berger, Ch.; Berger, N.; Berndt, T.; Bizot, J. C.; Böhme, J.; Boenig, M.-O.; Boudry, V.; Bracinik, J.; Brisson, V.; Bröker, H.-B.; Brown, D. P.; Bruncko, D.; Büsser, F. W.; Bunyatyan, A.; Buschhorn, G.; Bystritskaya, L.; Campbell, A. J.; Caron, S.; Cassol-Brunner, F.; Cerny, K.; Chekelian, V.; Contreras, J. G.; Coppens, Y. R.; Coughlan, J. A.; Cox, B. E.; Cozzika, G.; Cvach, J.; Dainton, J. B.; Dau, W. D.; Daum, K.; Delcourt, B.; Demirchyan, R.; De Roeck, A.; Desch, K.; De Wolf, E. A.; Diaconu, C.; Dingfelder, J.; Dodonov, V.; Dubak, A.; Duprel, C.; Eckerlin, G.; Efremenko, V.; Egli, S.; Eichler, R.; Eisele, F.; Ellerbrock, M.; Elsen, E.; Erdmann, M.; Erdmann, W.; Faulkner, P. J. W.; Favart, L.; Fedotov, A.; Felst, R.; Ferencei, J.; Fleischer, M.; Fleischmann, P.; Fleming, Y. H.; Flucke, G.; Flügge, G.; Fomenko, A.; Foresti, I.; Formánek, J.; Franke, G.; Frising, G.; Gabathuler, E.; Gabathuler, K.; Garutti, E.; Garvey, J.; Gayler, J.; Gerhards, R.; Gerlich, C.; Ghazaryan, S.; Ginzburgskaya, S.; Goerlich, L.; Gogitidze, N.; Gorbounov, S.; Grab, C.; Grässler, H.; Greenshaw, T.; Gregori, M.; Grindhammer, G.; Gwilliam, C.; Haidt, D.; Hajduk, L.; Haller, J.; Hansson, M.; Heinzelmann, G.; Henderson, R. C. W.; Henschel, H.; Henshaw, O.; Herrera, G.; Herynek, I.; Heuer, R.-D.; Hildebrandt, M.; Hiller, K. H.; Höting, P.; Hoffmann, D.; Horisberger, R.; Hovhannisyan, A.; Ibbotson, M.; Ismail, M.; Jacquet, M.; Janauschek, L.; Janssen, X.; Jemanov, V.; Jönsson, L.; Johnson, D. P.; Jung, H.; Kant, D.; Kapichine, M.; Karlsson, M.; Katzy, J.; Keller, N.; Kennedy, J.; Kenyon, I. R.; Kiesling, C.; Klein, M.; Kleinwort, C.; Klimkovich, T.; Kluge, T.; Knies, G.; Knutsson, A.; Koblitz, B.; Korbel, V.; Kostka, P.; Koutouev, R.; Kropivnitskaya, A.; Kroseberg, J.; Krüger, K.; Kückens, J.; Kuhr, T.; Landon, M. P. J.; Lange, W.; Laštovička, T.; Laycock, P.; Lebedev, A.; Leißner, B.; Lemrani, R.; Lendermann, V.; Levonian, S.; Lindfeld, L.; Lipka, K.; List, B.; Lobodzinska, E.; Loktionova, N.; Lopez-Fernandez, R.; Lubimov, V.; Lueders, H.; Lüke, D.; Lux, T.; Lytkin, L.; Makankine, A.; Malden, N.; Malinovski, E.; Mangano, S.; Marage, P.; Marks, J.; Marshall, R.; Martisikova, M.; Martyn, H.-U.; Maxfield, S. J.; Meer, D.; Mehta, A.; Meier, K.; Meyer, A. B.; Meyer, H.; Meyer, J.; Mikocki, S.; Milcewicz-Mika, I.; Milstead, D.; Mohamed, A.; Moreau, F.; Morozov, A.; Morozov, I.; Morris, J. V.; Mozer, M. U.; Müller, K.; Murín, P.; Nagovizin, V.; Nankov, K.; Naroska, B.; Naumann, J.; Naumann, Th.; Newman, P. R.; Niebuhr, C.; Nikiforov, A.; Nikitin, D.; Nowak, G.; Nozicka, M.; Oganezov, R.; Olivier, B.; Olsson, J. E.; Ossoskov, G.; Ozerov, D.; Paramonov, A.; Pascaud, C.; Patel, G. D.; Peez, M.; Perez, E.; Perieanu, A.; Petrukhin, A.; Pitzl, D.; Plačakytė, R.; Pöschl, R.; Portheault, B.; Povh, B.; Raicevic, N.; Reimer, P.; Reisert, B.; Rimmer, A.; Risler, C.; Rizvi, E.; Robmann, P.; Roland, B.; Roosen, R.; Rostovtsev, A.; Rurikova, Z.; Rusakov, S.; Rybicki, K.; Sankey, D. P. C.; Sauvan, E.; Schätzel, S.; Scheins, J.; Schilling, F.-P.; Schleper, P.; Schmidt, S.; Schmitt, S.; Schneider, M.; Schoeffel, L.; Schöning, A.; Schröder, V.; Schultz-Coulon, H.-C.; Schwanenberger, C.; Sedlák, K.; Sefkow, F.; Sheviakov, I.; Shtarkov, L. N.; Sirois, Y.; Sloan, T.; Smirnov, P.; Soloviev, Y.; South, D.; Spaskov, V.; Specka, A.; Spitzer, H.; Stamen, R.; Stella, B.; Stiewe, J.; Strauch, I.; Straumann, U.; Tchoulakov, V.; Thompson, G.; Thompson, P. D.; Tomasz, F.; Traynor, D.; Truöl, P.; Tsipolitis, G.; Tsurin, I.; Turnau, J.; Tzamariudaki, E.; Uraev, A.; Urban, M.; Usik, A.; Utkin, D.; Valkár, S.; Valkárová, A.; Vallée, C.; Van Mechelen, P.; Van Remortel, N.; Vargas Trevino, A.; Vazdik, Y.; Veelken, C.; Vest, A.; Vinokurova, S.; Volchinski, V.; Wacker, K.; Wagner, J.; Weber, G.; Weber, R.; Wegener, D.; Werner, C.; Werner, N.; Wessels, M.; Wessling, B.; Winter, G.-G.; Wissing, Ch.; Woehrling, E.-E.; Wolf, R.; Wünsch, E.; Xella, S.; Yan, W.; Yeganov, V.; Žáček, J.; Zálešák, J.; Zhang, Z.; Zhelezov, A.; Zhokin, A.; Zohrabyan, H.; Zomer, F.; H1 Collaboration

    2004-11-01

    A model-independent search for deviations from the Standard Model prediction is performed in ep and ep collisions at HERA using H1 data corresponding to an integrated luminosity of 117 pb. For the first time all event topologies involving isolated electrons, photons, muons, neutrinos and jets with high transverse momenta are investigated in a single analysis. Events are assigned to exclusive classes according to their final state. A statistical algorithm is developed to search for deviations from the Standard Model in the distributions of the scalar sum of transverse momenta or invariant mass of final state particles and to quantify their significance. A good agreement with the Standard Model prediction is observed in most of the event classes. The most significant deviation is found for a topology containing an isolated muon, missing transverse momentum and a jet, consistent with a previously reported observation.

  19. Gap anisotropy and van Hove singularities in high {Tc} superconductors

    SciTech Connect

    Bok, J.; Bouvier, J.

    1996-12-31

    The authors compute the superconducting gap {Delta}{sub {rvec k}} using a simple band structure of the CuO{sub 2} planes in the high Tc materials. They suppose that for materials with doping corresponding to maximum {Tc}, the van Hove singularities lie close to the Fermi level as is confirmed by many photoemission experiments. They use a electron-photon interaction with weak screening, they find a strong gap anisotropy. For Bi 2212, {Delta} is maximum along the 100 and 010 directions with values between 20 and 30 meV and minimum along 110 with values between 0 and 10 meV. They use this anisotropic gap to compute the quasi-particle excitations density of states and the tunneling current-voltage I(V) characteristic for N-I-S and S-I-S junctions. This model agrees remarkably well with recent experiments of tunneling spectroscopy in high {Tc} cuprates.

  20. Vertically integrated photonic multichip module architecture for vision applications

    NASA Astrophysics Data System (ADS)

    Tanguay, Armand R., Jr.; Jenkins, B. Keith; von der Malsburg, Christoph; Mel, Bartlett; Holt, Gary; O'Brien, John D.; Biederman, Irving; Madhukar, Anupam; Nasiatka, Patrick; Huang, Yunsong

    2000-05-01

    The development of a truly smart camera, with inherent capability for low latency semi-autonomous object recognition, tracking, and optimal image capture, has remained an elusive goal notwithstanding tremendous advances in the processing power afforded by VLSI technologies. These features are essential for a number of emerging multimedia- based applications, including enhanced augmented reality systems. Recent advances in understanding of the mechanisms of biological vision systems, together with similar advances in hybrid electronic/photonic packaging technology, offer the possibility of artificial biologically-inspired vision systems with significantly different, yet complementary, strengths and weaknesses. We describe herein several system implementation architectures based on spatial and temporal integration techniques within a multilayered structure, as well as the corresponding hardware implementation of these architectures based on the hybrid vertical integration of multiple silicon VLSI vision chips by means of dense 3D photonic interconnections.

  1. Simulation of spectral properties of bundlelike gold nanorods

    NASA Astrophysics Data System (ADS)

    Ozaki, Ryotaro; Nagao, Yoshiki; Kadowaki, Kazunori; Kuwahara, Yutaka

    2016-03-01

    Metal nanoparticles have become increasingly important in fields such as electronics, photonics, and biotechnology. In particular, anisotropic gold nanoparticles, such as gold nanorods, exhibit unique properties owing to their anisotropy. Optical properties of isolated gold nanorods and dimers of gold nanorods have been investigated from both experimental and theoretical points of view. We have reported a method for three-dimensional assembly of anisotropic gold nanoparticles by two-phase transfer in which the morphologies of the assemblies can be controlled by the aspect ratio of nanorods. In this study, we numerically calculate extinction spectra to investigate the plasmonic properties of bundlelike assemblies by the finite-element method. Their plasmonic properties depend on not only the three orthogonal directions but also the alignment of the nanorod assembly.

  2. Bound polarons in semiconductor nanostructures

    NASA Astrophysics Data System (ADS)

    Woggon, U.; Miller, D.; Kalina, F.; Gerlach, B.; Kayser, D.; Leonardi, K.; Hommel, D.

    2003-01-01

    Bound polarons are discrete, confined electronic states, spatially localized due to a local potential V(r) but sharing a common phonon state of the surrounding crystal. We study the energy states of polarons bound in a potential and determine the local optical absorption spectrum up to first-order time-dependent perturbation theory with respect to the electron-photon interaction. The model is applied to describe the optical properties of submonolayer CdSe insertions epitaxially grown between ZnSe layers. As a typical signature of bound polarons we found excited-state energies equidistantly separated by the LO phonon energy and with optical transition probabilities determined by the anisotropies in V(r).

  3. Chip scale integrated microresonator sensing systems.

    PubMed

    Jokerst, Nan; Royal, Matthew; Palit, Sabarni; Luan, Lin; Dhar, Sulochana; Tyler, Talmage

    2009-04-01

    Medicine, environmental monitoring, and security are application areas for miniaturized, portable sensing systems. The emerging integration of sensors with other components (electronic, photonic, fluidic) is moving sensing toward higher levels of portability through the realization of self-contained chip scale sensing systems. Planar optical sensors, and in particular, microresonator sensors, are attractive components for chip scale integrated sensing systems because they are small, have high sensitivity, can be surface customized, and can be integrated singly or in arrays in a planar format with other components using conventional semiconductor fabrication technologies. This paper will focus on the progress and prospects for the integration of microresonator sensors at the chip scale with photonic input/output components and with sample preparation microfluidics, toward self-contained, portable sensing systems. PMID:19367589

  4. Overview of the Defense Programs Research and Technology Development Program for fiscal year 1993. Appendix II research laboratories and facilities

    SciTech Connect

    Not Available

    1993-09-30

    This document contains summaries of the research facilities that support the Defense Programs Research and Technology Development Program for FY 1993. The nine program elements are aggregated into three program clusters as follows: (1) Advanced materials sciences and technologies; chemistry and materials, explosives, special nuclear materials (SNM), and tritium. (2) Design sciences and advanced computation; physics, conceptual design and assessment, and computation and modeling. (3) Advanced manufacturing technologies and capabilities; system engineering science and technology, and electronics, photonics, sensors, and mechanical components. Section I gives a brief summary of 23 major defense program (DP) research and technology facilities and shows how these major facilities are organized by program elements. Section II gives a more detailed breakdown of the over 200 research and technology facilities being used at the Laboratories to support the Defense Programs mission.

  5. Low-cost fabrication technologies for nanostructures: state-of-the-art and potential.

    PubMed

    Santos, A; Deen, M J; Marsal, L F

    2015-01-30

    In the last decade, some low-cost nanofabrication technologies used in several disciplines of nanotechnology have demonstrated promising results in terms of versatility and scalability for producing innovative nanostructures. While conventional nanofabrication technologies such as photolithography are and will be an important part of nanofabrication, some low-cost nanofabrication technologies have demonstrated outstanding capabilities for large-scale production, providing high throughputs with acceptable resolution and broad versatility. Some of these nanotechnological approaches are reviewed in this article, providing information about the fundamentals, limitations and potential future developments towards nanofabrication processes capable of producing a broad range of nanostructures. Furthermore, in many cases, these low-cost nanofabrication approaches can be combined with traditional nanofabrication technologies. This combination is considered a promising way of generating innovative nanostructures suitable for a broad range of applications such as in opto-electronics, nano-electronics, photonics, sensing, biotechnology or medicine. PMID:25567484

  6. Direct-gap optical gain of Ge on Si at room temperature.

    PubMed

    Liu, Jifeng; Sun, Xiaochen; Kimerling, Lionel C; Michel, Jurgen

    2009-06-01

    Lasers on Si are crucial components of monolithic electronic-photonic integration. Recently our theoretical analysis has shown that Ge, a pseudodirect bandgap material compatible with Si complementary metal oxide semiconductor technology, can be band engineered by tensile strain and n-type doping to achieve efficient light emission and optical gain from its direct gap transition. We report on what is to our knowledge the first experimental observation of optical gain in the wavelength range of 1,600-1,608 nm from the direct-gap transition of n(+) tensile-strained Ge on Si at room temperature under steady-state optical pumping. This experimental result confirms that the band-engineered Ge on Si is a promising gain medium for monolithic lasers on Si. PMID:19488166

  7. The Irradiation Effect of a Simultaneous Laser and Electron Dual-beam on Void Formation

    PubMed Central

    Yang, Zhanbing; Watanabe, Seiichi; Kato, Takahiko

    2013-01-01

    Randomly distributed lattice point defects such as supersaturated vacancies (SVs) and Frenkel-pairs (FPs, an interstitial and a vacancy) can be simultaneously introduced into the crystal by energetic beam irradiation in outer space and/or nuclear reactors, but their behavior has not been fully understood. Using a high-voltage electron microscope equipped with a laser (laser-HVEM), we show the striking effects of simultaneous laser-electron (photon-electron) dual-beam irradiation on void formation. Our results reveal that during laser-electron sequential irradiation, pre-laser irradiation enhanced void nucleation and subsequent electron irradiation enhanced void growth. However, the laser-electron dual-beam irradiation was analyzed to depress void swelling remarkably because the recombination of SVs and interstitials was enhanced. The results provide insight into the mechanism underlying the dual-beam radiation-induced depression of void swelling in solids. PMID:23383371

  8. Three-dimensional Aerographite-GaN hybrid networks: Single step fabrication of porous and mechanically flexible materials for multifunctional applications

    NASA Astrophysics Data System (ADS)

    Schuchardt, Arnim; Braniste, Tudor; Mishra, Yogendra K.; Deng, Mao; Mecklenburg, Matthias; Stevens-Kalceff, Marion A.; Raevschi, Simion; Schulte, Karl; Kienle, Lorenz; Adelung, Rainer; Tiginyanu, Ion

    2015-03-01

    Three dimensional (3D) elastic hybrid networks built from interconnected nano- and microstructure building units, in the form of semiconducting-carbonaceous materials, are potential candidates for advanced technological applications. However, fabrication of these 3D hybrid networks by simple and versatile methods is a challenging task due to the involvement of complex and multiple synthesis processes. In this paper, we demonstrate the growth of Aerographite-GaN 3D hybrid networks using ultralight and extremely porous carbon based Aerographite material as templates by a single step hydride vapor phase epitaxy process. The GaN nano- and microstructures grow on the surface of Aerographite tubes and follow the network architecture of the Aerographite template without agglomeration. The synthesized 3D networks are integrated with the properties from both, i.e., nanoscale GaN structures and Aerographite in the form of flexible and semiconducting composites which could be exploited as next generation materials for electronic, photonic, and sensors applications.

  9. Active Thermal Extraction and Temperature Sensing of Near-field Thermal Radiation

    PubMed Central

    Ding, D.; Kim, T.; Minnich, A. J.

    2016-01-01

    Recently, we proposed an active thermal extraction (ATX) scheme that enables thermally populated surface phonon polaritons to escape into the far-field. The concept is based on a fluorescence upconversion process that also occurs in laser cooling of solids (LCS). Here, we present a generalized analysis of our scheme using the theoretical framework for LCS. We show that both LCS and ATX can be described with the same mathematical formalism by replacing the electron-phonon coupling parameter in LCS with the electron-photon coupling parameter in ATX. Using this framework, we compare the ideal efficiency and power extracted for the two schemes and examine the parasitic loss mechanisms. This work advances the application of ATX to manipulate near-field thermal radiation for applications such as temperature sensing and active radiative cooling. PMID:27595609

  10. Transport properties of quark and gluon plasmas

    SciTech Connect

    Heiselberg, H.

    1993-12-01

    The kinetic properties of relativistic quark-gluon and electron-photon plasmas are described in the weak coupling limit. The troublesome Rutherford divergence at small scattering angles is screened by Debye screening for the longitudinal or electric part of the interactions. The transverse or magnetic part of the interactions is effectively screened by Landau damping of the virtual photons and gluons transferred in the QED and QCD interactions respectively. Including screening a number of transport coefficients for QCD and QED plasmas can be calculated to leading order in the interaction strength, including rates of momentum and thermal relaxation, electrical conductivity, viscosities, flavor and spin diffusion of both high temperature and degenerate plasmas. Damping of quarks and gluons as well as color diffusion in quark-gluon plasmas is, however, shown not to be sufficiently screened and the rates depends on an infrared cut-off of order the ``magnetic mass,`` m{sub mag} {approximately} g{sup 2}T.

  11. Influence of the vacuum-lunar regolith interface on the generation of radio emission by a cascade shower from an ultrahigh-energy particle

    SciTech Connect

    Filonenko, A. D.

    2012-03-15

    We present the results of our calculation of the radio emission field produced by an electron-photon shower from an ultrahigh-energy particle under the surface of the Moon. We consider two cases of cascade propagation: the first in the lunar regolith-vacuum direction at small angles to the interface; and the second in the opposite direction when the particle generates a cascade almost immediately after it has crossed the vacuum-regolith interface. To calculate the relative energy density of the emission emerged at the surface, we have used the method of decomposing spherical waves into plane ones. The intensity of the refracted waves for high frequencies has been found to depend strongly on the shower inclination angle.

  12. Calorimetry Triggering in ATLAS

    SciTech Connect

    Igonkina, O.; Achenbach, R.; Adragna, P.; Aharrouche, M.; Alexandre, G.; Andrei, V.; Anduaga, X.; Aracena, I.; Backlund, S.; Baines, J.; Barnett, B.M.; Bauss, B.; Bee, C.; Behera, P.; Bell, P.; Bendel, M.; Benslama, K.; Berry, T.; Bogaerts, A.; Bohm, C.; Bold, T.; /UC, Irvine /AGH-UST, Cracow /Birmingham U. /Barcelona, IFAE /CERN /Birmingham U. /Rutherford /Montreal U. /Santa Maria U., Valparaiso /DESY /DESY, Zeuthen /Geneva U. /City Coll., N.Y. /Barcelona, IFAE /CERN /Birmingham U. /Kirchhoff Inst. Phys. /Birmingham U. /Lisbon, LIFEP /Rio de Janeiro Federal U. /City Coll., N.Y. /Birmingham U. /Copenhagen U. /Copenhagen U. /Brookhaven /Rutherford /Royal Holloway, U. of London /Pennsylvania U. /Montreal U. /SLAC /CERN /Michigan State U. /Chile U., Catolica /City Coll., N.Y. /Oxford U. /La Plata U. /McGill U. /Mainz U., Inst. Phys. /Hamburg U. /DESY /DESY, Zeuthen /Geneva U. /Queen Mary, U. of London /CERN /Rutherford /Rio de Janeiro Federal U. /Birmingham U. /Montreal U. /CERN /Kirchhoff Inst. Phys. /Liverpool U. /Royal Holloway, U. of London /Pennsylvania U. /Kirchhoff Inst. Phys. /Geneva U. /Birmingham U. /NIKHEF, Amsterdam /Rutherford /Royal Holloway, U. of London /Rutherford /Royal Holloway, U. of London /AGH-UST, Cracow /Mainz U., Inst. Phys. /Mainz U., Inst. Phys. /Birmingham U. /Hamburg U. /DESY /DESY, Zeuthen /Geneva U. /Kirchhoff Inst. Phys. /Michigan State U. /Stockholm U. /Stockholm U. /Birmingham U. /CERN /Montreal U. /Stockholm U. /Arizona U. /Regina U. /Regina U. /Rutherford /NIKHEF, Amsterdam /Kirchhoff Inst. Phys. /DESY /DESY, Zeuthen /City Coll., N.Y. /University Coll. London /Humboldt U., Berlin /Queen Mary, U. of London /Argonne /LPSC, Grenoble /Arizona U. /Kirchhoff Inst. Phys. /Birmingham U. /Antonio Narino U. /Hamburg U. /DESY /DESY, Zeuthen /Kirchhoff Inst. Phys. /Birmingham U. /Chile U., Catolica /Indiana U. /Manchester U. /Kirchhoff Inst. Phys. /Rutherford /City Coll., N.Y. /Stockholm U. /La Plata U. /Antonio Narino U. /Queen Mary, U. of London /Kirchhoff Inst. Phys. /Antonio Narino U. /Pavia U. /City Coll., N.Y. /Mainz U., Inst. Phys. /Mainz U., Inst. Phys. /Pennsylvania U. /Barcelona, IFAE /Barcelona, IFAE /Chile U., Catolica /Genoa U. /INFN, Genoa /Rutherford /Barcelona, IFAE /Nevis Labs, Columbia U. /CERN /Antonio Narino U. /McGill U. /Rutherford /Santa Maria U., Valparaiso /Rutherford /Chile U., Catolica /Brookhaven /Oregon U. /Mainz U., Inst. Phys. /Barcelona, IFAE /McGill U. /Antonio Narino U. /Antonio Narino U. /Kirchhoff Inst. Phys. /Sydney U. /Rutherford /McGill U. /McGill U. /Pavia U. /Genoa U. /INFN, Genoa /Kirchhoff Inst. Phys. /Kirchhoff Inst. Phys. /Mainz U., Inst. Phys. /Barcelona, IFAE /SLAC /Stockholm U. /Moscow State U. /Stockholm U. /Birmingham U. /Kirchhoff Inst. Phys. /DESY /DESY, Zeuthen /Birmingham U. /Geneva U. /Oregon U. /Barcelona, IFAE /University Coll. London /Royal Holloway, U. of London /Birmingham U. /Mainz U., Inst. Phys. /Birmingham U. /Birmingham U. /Oregon U. /La Plata U. /Geneva U. /Chile U., Catolica /McGill U. /Pavia U. /Barcelona, IFAE /Regina U. /Birmingham U. /Birmingham U. /Kirchhoff Inst. Phys. /Oxford U. /CERN /Kirchhoff Inst. Phys. /UC, Irvine /UC, Irvine /Wisconsin U., Madison /Rutherford /Mainz U., Inst. Phys. /CERN /Geneva U. /Copenhagen U. /City Coll., N.Y. /Wisconsin U., Madison /Rio de Janeiro Federal U. /Wisconsin U., Madison /Stockholm U. /University Coll. London

    2011-12-08

    The ATLAS experiment is preparing for data taking at 14 TeV collision energy. A rich discovery physics program is being prepared in addition to the detailed study of Standard Model processes which will be produced in abundance. The ATLAS multi-level trigger system is designed to accept one event in 2/10{sup 5} to enable the selection of rare and unusual physics events. The ATLAS calorimeter system is a precise instrument, which includes liquid Argon electro-magnetic and hadronic components as well as a scintillator-tile hadronic calorimeter. All these components are used in the various levels of the trigger system. A wide physics coverage is ensured by inclusively selecting events with candidate electrons, photons, taus, jets or those with large missing transverse energy. The commissioning of the trigger system is being performed with cosmic ray events and by replaying simulated Monte Carlo events through the trigger and data acquisition system.

  13. Facile strain analysis of largely bending films by a surface-labelled grating method

    PubMed Central

    Akamatsu, Norihisa; Tashiro, Wataru; Saito, Keisuke; Mamiya, Jun-ichi; Kinoshita, Motoi; Ikeda, Tomiki; Takeya, Jun; Fujikawa, Shigenori; Priimagi, Arri; Shishido, Atsushi

    2014-01-01

    Mechanical properties of flexible films, for example surface strain of largely bending films, are key to design of stretchable electronic devices, wearable biointegrated devices, and soft microactuators/robots. However, existing methods are mainly based on strain-gauge measurements that require miniaturized array sensors, lead wires, and complicated calibrations. Here we introduce a facile method, based on surface-labelled gratings, for two-dimensional evaluation of surface strains in largely bending films. With this technique, we demonstrate that soft-matter mechanics can be distinct from the mechanics of hard materials. In particular, liquid-crystalline elastomers may undergo unconventional bending in three dimensions, in which both the inner and outer surfaces of the bending film are compressed. We also show that this method can be applied to amorphous elastomeric films, which highlights the general importance of this new mechanical evaluation tool in designing soft-matter-based electronic/photonic as well as biointegrated materials. PMID:24948462

  14. Laser-driven electron beam and radiation sources for basic, medical and industrial sciences.

    PubMed

    Nakajima, Kazuhisa

    2015-01-01

    To date active research on laser-driven plasma-based accelerators have achieved great progress on production of high-energy, high-quality electron and photon beams in a compact scale. Such laser plasma accelerators have been envisaged bringing a wide range of applications in basic, medical and industrial sciences. Here inheriting the groundbreaker's review article on "Laser Acceleration and its future" [Toshiki Tajima, (2010)],(1)) we would like to review recent progress of producing such electron beams due to relativistic laser-plasma interactions followed by laser wakefield acceleration and lead to the scaling formulas that are useful to design laser plasma accelerators with controllability of beam energy and charge. Lastly specific examples of such laser-driven electron/photon beam sources are illustrated. PMID:26062737

  15. Future nano- and micro-systems using nanobonding technologies

    SciTech Connect

    Howlader, Matiar M. R. E-mail: jamal@mcmaster.ca; Deen, M. Jamal E-mail: jamal@mcmaster.ca

    2014-03-31

    In this paper, some of the recent achievements in surface-activation-based nanobonding technology are described. This bonding technology allows for the combination of electronic, photonic, fluidic and mechanical functionalities into small form-factor systems for emerging applications in health diagnostics and screening, for example. These nanobonding technologies provide void-free, strong, and nanoscale bonding at room temperature or at low temperatures (<200 °C), and they do not require chemicals, adhesives, or high external pressure. The interfaces of the nanobonded materials in ultra-high vacuum and in air correspond to the covalent bonds, and hydrogen and hydroxyl bonds, respectively, which gives rise to excellent bonding properties. Further, these nanobonding technologies are well-suited for the development of low-cost, high-performance miniaturized systems such as biophotonic imaging systems.

  16. The Molecular Photo-Cell: Quantum Transport and Energy Conversion at Strong Non-Equilibrium

    PubMed Central

    Ajisaka, Shigeru; Žunkovič, Bojan; Dubi, Yonatan

    2015-01-01

    The molecular photo-cell is a single molecular donor-acceptor complex attached to electrodes and subject to external illumination. Besides the obvious relevance to molecular photo-voltaics, the molecular photo-cell is of interest being a paradigmatic example for a system that inherently operates in out-of-equilibrium conditions and typically far from the linear response regime. Moreover, this system includes electrons, phonons and photons, and environments which induce coherent and incoherent processes, making it a challenging system to address theoretically. Here, using an open quantum systems approach, we analyze the non-equilibrium transport properties and energy conversion performance of a molecular photo-cell, including both coherent and incoherent processes and treating electrons, photons, and phonons on an equal footing. We find that both the non-equilibrium conditions and decoherence play a crucial role in determining the performance of the photovoltaic conversion and the optimal energy configuration of the molecular system. PMID:25660494

  17. Lateral distribution on charged particles in EAS

    NASA Technical Reports Server (NTRS)

    Dedenko, L. G.; Sulakov, V. F.; Kulikov, G. V.; Solovjeva, V. I.

    1985-01-01

    Lateral distribution of charged particles which allow for the finiteness of energy gamma-quanta, the inhomogeneity of the atmosphere and the experimental selection of EAS are needed to interpret experimental data. The effects of finiteness of energy of gamma-quanta which produce the partial electron-photon cascades were considered by substituting K R sub m instead of R sub m in NKG approximation where K was found to be 0.56 from comparison with the experimental data. New results on the lateral distribution of electrons in the partial cascades from gamma-quanta were obtained. It is shown that the coefficient K can be regarded as a constant. The last approximation of K was found to be most adequate when compared with the experimental data. The inhomogeneity of the atmosphere, muons and experimental selection are considered. The calculation of Ne are extended from 100,000 to 10 million for sea level and for Akeno level.

  18. Fabrication and design of metal nano-accordion structures using atomic layer deposition and interference lithography.

    PubMed

    Min, J-H; Bagal, A; Mundy, J Z; Oldham, C J; Wu, B-I; Parsons, G N; Chang, C-H

    2016-03-01

    Metal nanostructures have attractive electrical and thermal properties as well as structural stability, and are important for applications in flexible conductors. In this study, we have developed a method to fabricate and control novel complex platinum nanostructures with accordion-like profile using atomic layer deposition on lithographically patterned polymer templates. The template removal process results in unique structural transformation of the nanostructure profile, which has been studied and modeled. Using different template duty cycles and aspect ratios, we have demonstrated a wide variety of cross-sectional profiles from wavy geometry to pipe array patterns. These complex thin metal nanostructures can find applications in flexible/stretchable electronics, photonics and nanofluidics. PMID:26863903

  19. Purely sonochemical route for oriented zinc oxide nanowire growth on arbitrary substrate

    NASA Astrophysics Data System (ADS)

    Nayak, Avinash P.; Katzenmeyer, Aaron M.; Kim, Ja-Yeon; Kwon, Min Ki; Gosho, Yasuhiro; Islam, M. Saif

    2010-04-01

    We report a simple sonochemical method for the seeding and synthesis of Zinc Oxide nanowire arrays that can be formed on a number of substrates that are stable in alcohol and aqueous solution. Vertically aligned ZnO NWs were synthesized from a single solution at room-ambient via ultrasonic excitation. Prior to the NW growth, a ZnO seed layer was deposited using the same system with a different solution. The optimal conditions to produce a high density of oriented wires along with their optical characteristics are presented for ZnO NWs with a significantly high growth rate compared with traditional growth techniques such as evaporation, chemical vapor deposition and sputtering. Our method promises a mass-manufacturable process for fast and inexpensive ZnO NW production for practical low cost electronics, photonics and energy conversion applications.

  20. POLYMERIC ACRYLATE-BASED HYBRID FILMS CONTAINING LEAD AND IRON PATTERNED BY UV PHOTO-POLYMERIZATION

    PubMed Central

    Han, Huilan; Bissell, John; Yaghmaie, Frank; Davis, Cristina E.

    2009-01-01

    The development and processing of hybrid inorganic-organic thin film materials plays a critical role in advancing interdisciplinary sciences and device manufacturing. Here we present a novel approach to synthesize and deposit acrylate-containing organic/inorganic hybrid films. The material is based on a chemical solution and includes specifically desired metal dopants that are fully-integrated into the backbone of the polymer structure. The film can be deposited by simple spin coating, and we confer photosensitive properties to the material making it directly patterned by traditional UV photolithography techniques. Film thickness, chemical characterization and wet/dry etching capability of the film are also investigated. We believe this innovative material has the potential to be used in a broad range of applications for electronic, photonic, biology and other interdisciplinary fields. PMID:19795818

  1. A comparison of experiment, CEPXS/ONETRAN, TIGERP, and TIGER net electron emission coefficients for various bremsstrahlung spectra

    SciTech Connect

    Ballard, W.P.; Lorence, L.J. Jr.; Snowden, D.P.; Van Lint, V.A.J.; Beale, E.S.

    1987-12-01

    This work compares a carefully designed experiment to measure photoemission with the predictions of three different codes (CEPXS/ONETRAN, TIGERP, and TIGER) for the complex bremsstrahlung spectra typical of very intense pulsed power x-ray generators. The Monte Carlo codes TIGER and TIGERP can calculate the net photon-induced electron emission but accurate results may require that statistical error be minimized. CEPXS/ONETRAN is a new deterministic coupled electron/photon transport code that is faster than Monte Carlo and is not subject to statistical error. The comparison of net yields is a sensitive test of the relative accuracy and efficiency of these various codes. The authors find that all of the codes substantially agree with the experiments for the forward net yields. However, for reverse net yields from high-Z materials, the codes overpredict relative to measurements.

  2. Chemical and biological sensing applications of integrated photonics with an introduction to the American Institute for Manufacturing Integrated Photonics (AIM Photonics)

    NASA Astrophysics Data System (ADS)

    Bickford, Justin; Guicheteau, Jason

    2016-05-01

    Integrated photonics affords an opportunity to explore novel sensing and lab-on-a-chip concepts. It offers a route to high sensitivity, high selectivity, and low SWaP-C test systems that can be operated autonomously or by minimallytrained field personnel. We'll introduce the topic, discuss possible sensing modalities, and highlight the advantages and limitations of this technology. We'll also introduce the recent American Institute for Manufacturing Integrated Photonics (AIM Photonics), give an overview of its vision and capabilities, how to utilize its Electronic-Photonic Design Automation (EPDA) tools and its Multi-Project Wafer and Assembly (MPWA) services, how to engage in its road mapping efforts, and how to become a contributing member.

  3. Photocatalytic Nanostructuring of Graphene Guided by Block Copolymer Self-Assembly.

    PubMed

    Wang, Zhongli; Li, Tao; Schulte, Lars; Almdal, Kristoffer; Ndoni, Sokol

    2016-04-01

    Nanostructured graphene exhibits many intriguing properties. For example, precisely controlled graphene nanomeshes can be applied in electronic, photonic, or sensing devices. However, fabrication of nanopatterned graphene with periodic supperlattice remains a challenge. In this work, periodic graphene nanomesh was fabricated by photocatalysis of single-layer graphene suspended on top of TiO2-covered nanopillars, which were produced by combining block copolymer nanolithography with atomic layer deposition. Graphene nanoribbons were also prepared by the same method applied to a line-forming block copolymer template. This mask-free and nonchemical/nonplasma route offers an exciting platform for nanopatterning of graphene and other UV-transparent materials for device engineering. PMID:26999508

  4. A single probe for imaging photons, electrons and physical forces

    NASA Astrophysics Data System (ADS)

    Pilet, Nicolas; Lisunova, Yuliya; Lamattina, Fabio; Stevenson, Stephanie E.; Pigozzi, Giancarlo; Paruch, Patrycja; Fink, Rainer H.; Hug, Hans J.; Quitmann, Christoph; Raabe, Joerg

    2016-06-01

    The combination of complementary measurement techniques has become a frequent approach to improve scientific knowledge. Pairing of the high lateral resolution scanning force microscopy (SFM) with the spectroscopic information accessible through scanning transmission soft x-ray microscopy (STXM) permits assessing physical and chemical material properties with high spatial resolution. We present progress from the NanoXAS instrument towards using an SFM probe as an x-ray detector for STXM measurements. Just by the variation of one parameter, the SFM probe can be utilised to detect either sample photo-emitted electrons or transmitted photons. This allows the use of a single probe to detect electrons, photons and physical forces of interest. We also show recent progress and demonstrate the current limitations of using a high aspect ratio coaxial SFM probe to detect photo-emitted electrons with very high lateral resolution. Novel probe designs are proposed to further progress in using an SFM probe as a STXM detector.

  5. A single probe for imaging photons, electrons and physical forces.

    PubMed

    Pilet, Nicolas; Lisunova, Yuliya; Lamattina, Fabio; Stevenson, Stephanie E; Pigozzi, Giancarlo; Paruch, Patrycja; Fink, Rainer H; Hug, Hans J; Quitmann, Christoph; Raabe, Joerg

    2016-06-10

    The combination of complementary measurement techniques has become a frequent approach to improve scientific knowledge. Pairing of the high lateral resolution scanning force microscopy (SFM) with the spectroscopic information accessible through scanning transmission soft x-ray microscopy (STXM) permits assessing physical and chemical material properties with high spatial resolution. We present progress from the NanoXAS instrument towards using an SFM probe as an x-ray detector for STXM measurements. Just by the variation of one parameter, the SFM probe can be utilised to detect either sample photo-emitted electrons or transmitted photons. This allows the use of a single probe to detect electrons, photons and physical forces of interest. We also show recent progress and demonstrate the current limitations of using a high aspect ratio coaxial SFM probe to detect photo-emitted electrons with very high lateral resolution. Novel probe designs are proposed to further progress in using an SFM probe as a STXM detector. PMID:27146329

  6. Measurement of electrical avalanches and optical radiation near solid insulators in high pressure (up to 0. 3 MPa) nitrogen gas

    SciTech Connect

    Mahajan, S.M. ); Sudarshan, T.S. )

    1991-03-01

    Electron and ion avalanches have been recorded near a variety of insulators (plexiglas, teflon, high-density polyethylene, low-density polyethylene, polypropylene, delrin, polyvinyl chloride, and nylon) in nitrogen gas at pressures of 0.1, 0.2, and 0.3 MPa. With the exception of nylon, suppression of avalanches has been observed in the presence of insulators. In addition to electron and ion avalanches, simultaneous measurement of optical radiation associated with an electron avalanche was successfully carried out. Qualitative explanations have been provided for the suppression of avalanches near most insulators and an anomalous growth of avalanches near nylon insulators. Photoemission from nylon surfaces appears to be responsible for the enhanced growth of avalanches near nylon insulators. More precise measurements of optical radiation are needed to better understand the electron-photon interactions near a solid insulator in a gaseous dielectric medium.

  7. Competition of static magnetic and dynamic photon forces in electronic transport through a quantum dot.

    PubMed

    Rauf Abdullah, Nzar; Tang, Chi-Shung; Manolescu, Andrei; Gudmundsson, Vidar

    2016-09-21

    We investigate theoretically the balance of the static magnetic and the dynamical photon forces in the electron transport through a quantum dot in a photon cavity with a single photon mode. The quantum dot system is connected to external leads and the total system is exposed to a static perpendicular magnetic field. We explore the transport characteristics through the system by tuning the ratio, [Formula: see text], between the photon energy, [Formula: see text], and the cyclotron energy, [Formula: see text]. Enhancement in the electron transport with increasing electron-photon coupling is observed when [Formula: see text]. In this case the photon field dominates and stretches the electron charge distribution in the quantum dot, extending it towards the contact area for the leads. Suppression in the electron transport is found when [Formula: see text], as the external magnetic field causes circular confinement of the charge density around the dot. PMID:27420809

  8. Accelerating execution of the integrated TIGER series Monte Carlo radiation transport codes

    SciTech Connect

    Smith, L.M.; Hochstedler, R.D.

    1997-02-01

    Execution of the integrated TIGER series (ITS) of coupled electron/photon Monte Carlo radiation transport codes has been accelerated by modifying the FORTRAN source code for more efficient computation. Each member code of ITS was benchmarked and profiled with a specific test case that directed the acceleration effort toward the most computationally intensive subroutines. Techniques for accelerating these subroutines included replacing linear search algorithms with binary versions, replacing the pseudo-random number generator, reducing program memory allocation, and proofing the input files for geometrical redundancies. All techniques produced identical or statistically similar results to the original code. Final benchmark timing of the accelerated code resulted in speed-up factors of 2.00 for TIGER (the one-dimensional slab geometry code), 1.74 for CYLTRAN (the two-dimensional cylindrical geometry code), and 1.90 for ACCEPT (the arbitrary three-dimensional geometry code).

  9. CAD/CAM for MEMS and BioMEMS

    NASA Astrophysics Data System (ADS)

    Hargrave, Brian; Irwin, Bryan; Parkhill, Robert; Church, Kenneth H.; Nguyen, Michael N.; Kachurin, Anatoly; Warren, William L.

    2004-07-01

    Novel devices can be relatively simple in theory and modeling, but difficult and many times unfeasible to fabricate in a traditional cleanroom environment. We have developed a CAD/CAM tool capable of integrating multiple materials in the electronic, photonic, and biological regimes for applications in both MEMS and BioMEMS devices. Some materials are known and more fully characterized, such as thick film resistors or conductors, while other materials such as biodegradable scaffolding are new but showing promise to realize heterogenous tissue engineered constructs and drug delivery devices. The tool does not discriminate, but rather places these materials in specified locations with precision volumetric control, gently, conformally, and in 3-D. This paper will describe the enabling aspect of true 3-D maskless fabrication as well as describe multiple device structures and demonstrations.

  10. Low-power chip-level optical interconnects based on bulk-silicon single-chip photonic transceivers

    NASA Astrophysics Data System (ADS)

    Kim, Gyungock; Park, Hyundai; Joo, Jiho; Jang, Ki-Seok; Kwack, Myung-Joon; Kim, Sanghoon; Kim, In Gyoo; Kim, Sun Ae; Oh, Jin Hyuk; Park, Jaegyu; Kim, Sanggi

    2016-03-01

    We present new scheme for chip-level photonic I/Os, based on monolithically integrated vertical photonic devices on bulk silicon, which increases the integration level of PICs to a complete photonic transceiver (TRx) including chip-level light source. A prototype of the single-chip photonic TRx based on a bulk silicon substrate demonstrated 20 Gb/s low power chip-level optical interconnects between fabricated chips, proving that this scheme can offer compact low-cost chip-level I/O solutions and have a significant impact on practical electronic-photonic integration in high performance computers (HPC), cpu-memory interface, 3D-IC, and LAN/SAN/data-center and network applications.

  11. Laser-driven electron beam and radiation sources for basic, medical and industrial sciences

    PubMed Central

    NAKAJIMA, Kazuhisa

    2015-01-01

    To date active research on laser-driven plasma-based accelerators have achieved great progress on production of high-energy, high-quality electron and photon beams in a compact scale. Such laser plasma accelerators have been envisaged bringing a wide range of applications in basic, medical and industrial sciences. Here inheriting the groundbreaker’s review article on “Laser Acceleration and its future” [Toshiki Tajima, (2010)],1) we would like to review recent progress of producing such electron beams due to relativistic laser-plasma interactions followed by laser wakefield acceleration and lead to the scaling formulas that are useful to design laser plasma accelerators with controllability of beam energy and charge. Lastly specific examples of such laser-driven electron/photon beam sources are illustrated. PMID:26062737

  12. Selected bibliography on atomic collisions: Data collections, bibliographies, review articles, books, and papers of particular tutorial value

    SciTech Connect

    McDaniel, E.W.; Flannery, M.R.; Thomas, E.W.; Manson, S.T.

    1985-07-01

    This bibliography deals mainly with binary and ternary collisions involving electrons, photons, and heavy particles (i.e., atoms, molecules, and ions). The energy range covered for each kind of collision is such that the interactions might be described as electronic, atomic, or chemical--higher-energy collisions involving nuclear forces are not treated. Also covered are particle and photon impact on surfaces, the passage of particles and radiation through bulk matter, and transport phenomena in gases. Practically all of the references cited are data compilations, other bibliographies, review articles, or books. The main objective is to provide easy access to atomic collision data, although some references are included principally for their tutorial value.

  13. Optical responses of a metal with sub-nm gaps

    PubMed Central

    Park, Sang Jun; Kim, Tae Yun; Park, Cheol-Hwan; Kim, Dai-Sik

    2016-01-01

    If the size of a metallic structure is reduced to be comparable to or even smaller than the typical quantum-mechanical lengths such as the Fermi wavelength or Thomas-Fermi wavelength, the electronic structure and optical responses are modulated by quantum effects. Here, we calculate the optical responses of a metal with sub-nm gaps using the eigenstates obtained from an effective-mass quantum theory. According to our simulation, the dielectric responses can be significantly modified by tuning the inter-gap distances. Remarkably, sub-nm gaps occupying a 0.3% volumetric fraction can elongate the penetration depth by an order of magnitude in the terahertz regime. We find that the detailed dependences of electron-photon interaction matrix elements on the involved electronic wavefunctions play an important role in the optical responses. The results draw our attention to these recently fabricated systems. PMID:26964884

  14. Supersymmetric signatures at an eγ collider

    NASA Astrophysics Data System (ADS)

    Kiers, Ken; Ng, John N.; Wu, Guohong

    1996-02-01

    High energy electron-photon colliders provide unique opportunities for probing physics beyond the standard model. We have studied the experimental signatures for two supersymmetric scenarios, with the lightest supersymmetric particle (LSP) being either the lightest neutralino or the gravitino. In the “neutralino LSP” scenario favored by the minimal supersymmetric standard model (MSSM), it is found that some basic parameters of the model, μ, tan β, M1 and M2, may be uniquely determined from the outgoing electron energy spectrum without assuming high scale unification of the masses or couplings. In the “gravitino LSP” scenario which occurs naturally in models of low energy dynamical supersymmetry breaking, it is possible to have background-free signatures if the next-to-lightest supersymmetric particle (NLSP) has a long decay length. In cases that the NLSP decays quickly, ways to distinguish among the experimental signatures of the two scenarios and of the standard model (SM) background are discussed.

  15. Active Thermal Extraction and Temperature Sensing of Near-field Thermal Radiation.

    PubMed

    Ding, D; Kim, T; Minnich, A J

    2016-01-01

    Recently, we proposed an active thermal extraction (ATX) scheme that enables thermally populated surface phonon polaritons to escape into the far-field. The concept is based on a fluorescence upconversion process that also occurs in laser cooling of solids (LCS). Here, we present a generalized analysis of our scheme using the theoretical framework for LCS. We show that both LCS and ATX can be described with the same mathematical formalism by replacing the electron-phonon coupling parameter in LCS with the electron-photon coupling parameter in ATX. Using this framework, we compare the ideal efficiency and power extracted for the two schemes and examine the parasitic loss mechanisms. This work advances the application of ATX to manipulate near-field thermal radiation for applications such as temperature sensing and active radiative cooling. PMID:27595609

  16. The Integrated TIGER Series Codes

    Energy Science and Technology Software Center (ESTSC)

    2006-01-15

    ITS is a powerful and user-friendly software package permitting state-of-the-art Monte Carlo solution of linear time-independent coupled electron/photon radiation transport problems, with or without the presence of macroscopic electric and magnetic fields of arbitrary spatial dependence. Our goal has been to simultaneously maximize operational simplicity and physical accuracy. Through a set of preprocessor directives, the user selects one of the many ITS codes. The ease with which the makefile system is applied combines with anmore » input scheme based on order-independent descriptive keywords that makes maximum use of defaults and intemal error checking to provide experimentalists and theorists alike with a method for the routine but rigorous solution of sophisticated radiation transport problems. Physical rigor is provided by employing accurate cross sections, sampling distributions, and physical models for describing the production and transport of the electron/photon cascade from 1.0 GeV down to 1.0 keV. The availability of source code permits the more sophisticated user to tailor the codes to specific applications and to extend the capabilities of the codes to more complex applications. Version 5.0, the latest version of ITS, contains (1) improvements to the ITS 3.0 continuous-energy codes, (2) multigroup codes with adjoint transport capabilities, (3) parallel implementations of all ITS codes, (4) a general purpose geometry engine for linking with CAD or other geometry formats, and (5) the Cholla facet geometry library. Moreover, the general user friendliness of the software has been enhanced through increased internal error checking and improved code portability.« less

  17. Extremely strong bipolar optical interactions in paired graphene nanoribbons.

    PubMed

    Lu, Wanli; Chen, Huajin; Liu, Shiyang; Zi, Jian; Lin, Zhifang

    2016-03-28

    Graphene is an excellent multi-functional platform for electrons, photons, and phonons due to exceptional electronic, photonic, and thermal properties. When combining its extraordinary mechanical characteristics with optical properties, graphene-based nanostructures can serve as an appealing platform for optomechanical applications at the nanoscale. Here, we demonstrate, using full-wave simulations, the emergence of extremely strong bipolar optical forces, or, optical binding and anti-binding, between a pair of coupled graphene nanoribbons, due to the remarkable confinement and enhancement of optical fields arising from the large effective mode indices. In particular, the binding and anti-binding forces, which are about two orders of magnitude stronger than that in metamaterials and high-Q resonators, can be tailored by selective excitation of either the even or the odd optical modes, achievable by tuning the relative phase of the lightwaves propagating along the two ribbons. Based on the coupled mode theory, we derive analytical formulae for the bipolar optical forces, which agree well with the numerical results. The attractive optical binding force F(y)(b) and the repulsive anti-binding force F(y)(a) exhibit a remarkably different dependence on the gap distance g between the nanoribbons and the Fermi energy E(F), in the forms of F(y)(b) ∝ 1/√(g³E(F)) and F(y)(a) ∝ 1/E(F)(2). With E(F) dynamically tunable by bias voltage, the bipolar forces may provide a flexible handle for active control of the nanoscale optomechanical effects, and also, might be significant for optoelectronic and optothermal applications as well. PMID:26948095

  18. Code System to Perform Monte Carlo Simulation of Electron Gamma-Ray Showers in Arbitrary Marerials.

    Energy Science and Technology Software Center (ESTSC)

    2002-10-15

    Version 00 PENELOPE performs Monte Carlo simulation of electron-photon showers in arbitrary materials. Initially, it was devised to simulate the PENetration and Energy LOss of Positrons and Electrons in matter; photons were introduced later. The adopted scattering model gives a reliable description of radiation transport in the energy range from a few hundred eV to about 1GeV. PENELOPE generates random electron-photon showers in complex material structures consisting of any number of distinct homogeneous regions (bodies)more » with different compositions. The Penelope Forum list archives and other information can be accessed at http://www.nea.fr/lists/penelope.html. PENELOPE-MPI extends capabilities of PENELOPE-2001 (RSICC C00682MNYCP02; NEA-1525/05) by providing for usage of MPI type parallel drivers and extends the original version's ability to read different types of input data sets such as voxel. The motivation is to increase efficiency of Monte Carlo simulations for medical applications. The physics of the calculations have not been changed, and the original description of PENELOPE-2001 (which follows) is still valid. PENELOPE-2001 contains substantial changes and improvements to the previous versions 1996 and 2000. As for the physics, the model for electron/positron elastic scattering has been revised. Bremsstrahlung emission is now simulated using partial-wave data instead of analytical approximate formulae. Photoelectric absorption in K and L-shells is described from the corresponding partial cross sections. Fluorescence radiation from vacancies in K and L-shells is followed. Refinements were also introduced in electron/positron transport mechanics, mostly to account for energy dependence of the mean free paths for hard events. Simulation routines were re-programmed in a more structured way, and new example MAIN programs were written with a more flexible input and expanded output.« less

  19. Focused-electron-beam-induced processing (FEBIP) for emerging applications in carbon nanoelectronics

    NASA Astrophysics Data System (ADS)

    Fedorov, Andrei G.; Kim, Songkil; Henry, Mathias; Kulkarni, Dhaval; Tsukruk, Vladimir V.

    2014-12-01

    Focused-electron-beam-induced processing (FEBIP), a resist-free additive nanomanufacturing technique, is an actively researched method for "direct-write" processing of a wide range of structural and functional nanomaterials, with high degree of spatial and time-domain control. This article attempts to critically assess the FEBIP capabilities and unique value proposition in the context of processing of electronics materials, with a particular emphasis on emerging carbon (i.e., based on graphene and carbon nanotubes) devices and interconnect structures. One of the major hurdles in advancing the carbon-based electronic materials and device fabrication is a disjoint nature of various processing steps involved in making a functional device from the precursor graphene/CNT materials. Not only this multi-step sequence severely limits the throughput and increases the cost, but also dramatically reduces the processing reproducibility and negatively impacts the quality because of possible between-the-step contamination, especially for impurity-susceptible materials such as graphene. The FEBIP provides a unique opportunity to address many challenges of carbon nanoelectronics, especially when it is employed as part of an integrated processing environment based on multiple "beams" of energetic particles, including electrons, photons, and molecules. This avenue is promising from the applications' prospective, as such a multi-functional (electron/photon/molecule beam) enables one to define shapes (patterning), form structures (deposition/etching), and modify (cleaning/doping/annealing) properties with locally resolved control on nanoscale using the same tool without ever changing the processing environment. It thus will have a direct positive impact on enhancing functionality, improving quality and reducing fabrication costs for electronic devices, based on both conventional CMOS and emerging carbon (CNT/graphene) materials.

  20. Treating electron transport in MCNP{sup trademark}

    SciTech Connect

    Hughes, H.G.

    1996-12-31

    The transport of electrons and other charged particles is fundamentally different from that of neutrons and photons. A neutron, in aluminum slowing down from 0.5 MeV to 0.0625 MeV will have about 30 collisions; a photon will have fewer than ten. An electron with the same energy loss will undergo 10{sup 5} individual interactions. This great increase in computational complexity makes a single- collision Monte Carlo approach to electron transport unfeasible for many situations of practical interest. Considerable theoretical work has been done to develop a variety of analytic and semi-analytic multiple-scattering theories for the transport of charged particles. The theories used in the algorithms in MCNP are the Goudsmit-Saunderson theory for angular deflections, the Landau an theory of energy-loss fluctuations, and the Blunck-Leisegang enhancements of the Landau theory. In order to follow an electron through a significant energy loss, it is necessary to break the electron`s path into many steps. These steps are chosen to be long enough to encompass many collisions (so that multiple-scattering theories are valid) but short enough that the mean energy loss in any one step is small (for the approximations in the multiple-scattering theories). The energy loss and angular deflection of the electron during each step can then be sampled from probability distributions based on the appropriate multiple- scattering theories. This subsumption of the effects of many individual collisions into single steps that are sampled probabilistically constitutes the ``condensed history`` Monte Carlo method. This method is exemplified in the ETRAN series of electron/photon transport codes. The ETRAN codes are also the basis for the Integrated TIGER Series, a system of general-purpose, application-oriented electron/photon transport codes. The electron physics in MCNP is similar to that of the Integrated TIGER Series.

  1. The Integrated TIGER Series Codes

    SciTech Connect

    Kensek, Ronald P.; Franke, Brian C.; Laub, Thomas W.

    2006-01-15

    ITS is a powerful and user-friendly software package permitting state-of-the-art Monte Carlo solution of linear time-independent coupled electron/photon radiation transport problems, with or without the presence of macroscopic electric and magnetic fields of arbitrary spatial dependence. Our goal has been to simultaneously maximize operational simplicity and physical accuracy. Through a set of preprocessor directives, the user selects one of the many ITS codes. The ease with which the makefile system is applied combines with an input scheme based on order-independent descriptive keywords that makes maximum use of defaults and intemal error checking to provide experimentalists and theorists alike with a method for the routine but rigorous solution of sophisticated radiation transport problems. Physical rigor is provided by employing accurate cross sections, sampling distributions, and physical models for describing the production and transport of the electron/photon cascade from 1.0 GeV down to 1.0 keV. The availability of source code permits the more sophisticated user to tailor the codes to specific applications and to extend the capabilities of the codes to more complex applications. Version 5.0, the latest version of ITS, contains (1) improvements to the ITS 3.0 continuous-energy codes, (2) multigroup codes with adjoint transport capabilities, (3) parallel implementations of all ITS codes, (4) a general purpose geometry engine for linking with CAD or other geometry formats, and (5) the Cholla facet geometry library. Moreover, the general user friendliness of the software has been enhanced through increased internal error checking and improved code portability.

  2. Nonisocentric Treatment Strategy for Breast Radiation Therapy: A Proof of Concept Study

    SciTech Connect

    Li, Ruijiang Xing, Lei; Horst, Kathleen C.; Bush, Karl

    2014-03-15

    Purpose: To propose a nonisocentric treatment strategy as a special form of station parameter optimized radiation therapy, to improve sparing of critical structures while preserving target coverage in breast radiation therapy. Methods and Materials: To minimize the volume of exposed lung and heart in breast irradiation, we propose a novel nonisocentric treatment scheme by strategically placing nonconverging beams with multiple isocenters. As its name suggests, the central axes of these beams do not intersect at a single isocenter as in conventional breast treatment planning. Rather, the isocenter locations and beam directions are carefully selected, in that each beam is only responsible for a certain subvolume of the target, so as to minimize the volume of irradiated normal tissue. When put together, the beams will provide an adequate coverage of the target and expose only a minimal amount of normal tissue to radiation. We apply the nonisocentric planning technique to 2 previously treated clinical cases (breast and chest wall). Results: The proposed nonisocentric technique substantially improved sparing of the ipsilateral lung. Compared with conventional isocentric plans using 2 tangential beams, the mean lung dose was reduced by 38% and 50% using the proposed technique, and the volume of the ipsilateral lung receiving ≥20 Gy was reduced by a factor of approximately 2 and 3 for the breast and chest wall cases, respectively. The improvement in lung sparing is even greater compared with volumetric modulated arc therapy. Conclusions: A nonisocentric implementation of station parameter optimized radiation therapy has been proposed for breast radiation therapy. The new treatment scheme overcomes the limitations of existing approaches and affords a useful tool for conformal breast radiation therapy, especially in cases with extreme chest wall curvature.

  3. SU-E-T-97: Dependence Of Optically Stimulated Luminescent Dosimeter (OSLD) Out Of Field Response On Volumetric Modulated Arc Therapy (VMAT) Field Modulation

    SciTech Connect

    Ware, S; Clouser, E

    2014-06-01

    Purpose: To determine the out of field response of Microstar ii OSLDs as a function of field modulation and distance in VMAT plan delivery. This work has potential application in fetal dose monitoring or measurements on cardiac pacemakers Methods: VMAT plans were created in Eclipse and optimized to varying degrees of modulation. Three plans were chosen to represent low, medium and high degrees of modulation (modulation factors as defined by MU/cGy). Plans were delivered to slabs of solid water with dimensions 60cm length, 30cm width, and 10cm height. For each modulation factor, 2 OSLDs were placed at 1cm depth with out of field distances of 1, 2, 3, 5, 8 and 10cm and the plan delivered isocentrically to a depth of 5cm. This technique was repeated for a Farmer Chamber by incrementing the table by the appropriate distance. The charge readings for the Farmer Chamber were converted to dose and the ratios taken as functions of modulation factors and distances out of field Results: Examination of the results as a function of out of field distance shows a trend of increasing OSLD/Farmer Chamber ratios for all modulation factors. The slopes appear to be roughly equivalent for all modulation factors investigated. Results as a function of modulation showed a downward trend for all out of field distances, with the greatest differences seen at 5cm and 8cm Conclusion: This study demonstrates that the response of OSLD dosimeters change as a function of out of field distance and modulation. The differences seen are within the stated accuracy of the system for the out of field distances and modulations investigated. Additional investigation is warranted to see if the OSLD response changes appreciably with longer out of field distances or wider ranges of modulation.

  4. Three-Dimensional Rotational Angiography of the Foot in Critical Limb Ischemia: A New Dimension in Revascularization Strategy

    SciTech Connect

    Jens, Sjoerd; Lucatelli, Pierleone; Koelemay, Mark J. W.; Marquering, Henk A. Reekers, Jim A.

    2013-06-15

    Purpose. To evaluate the additional value of three-dimensional rotational angiography (3DRA) of the foot compared with digital subtraction angiography (DSA) in patients with critical limb ischemia (CLI). Technique. For 3DRA, the C-arm was placed in the propeller position with the foot in an isocentric position. The patient's unaffected foot was positioned in a footrest outside the field of view. For correct timing of 3DRA, the delay from contrast injection in the popliteal artery at the level of knee joint to complete pedal arterial enhancement was assessed using DSA. With this delay, 3DRA was started after injection of 15 ml contrast. Imaging of the 3DRA could directly be reconstructed and visualized.Materials and MethodsPatients undergoing 3DRA of the foot were prospectively registered. DSA and 3DRA images were scored separately for arterial patency and presence of collaterals. Treatment strategies were proposed based on DSA with and without the availability of 3DRA. Results. Eleven patients underwent 3DRA of the foot. One 3DRA was not included because the acquisition was focused on the heel instead of the entire foot. Diagnostic quality of 3DRA was good in all ten patients. 3DRA compared with DSA showed additional patent arteries in six patients, patent plantar arch in three patients, and collaterals between the pedal arteries in five patients. Additional information from 3DRA resulted in a change of treatment strategy in six patients. Conclusion, 3DRA of the foot contains valuable additional real-time information to better guide peripheral vascular interventions in patients with CLI and nonhealing tissue lesions.

  5. Consideration of optimal isodose surface selection for target coverage in micro-multileaf collimator-based stereotactic radiotherapy for large cystic brain metastases: comparison of 90%, 80% and 70% isodose surface-based planning

    PubMed Central

    Ohtakara, K; Hayashi, S; Tanaka, H; Hoshi, H

    2012-01-01

    Objective This study aims to compare dynamic conformal arc (DCA) plans based on different-percentage isodose surfaces (IDSs), normalised to 100% at the isocentre, for target coverage (TC; dose prescription) in stereotactic radiotherapy for large cystic brain metastases. Methods The DCA plans were generated for 15 targets (5 spherical models and 10 metastatic brain lesions) based on 90%, 80% and 70% IDSs for dose prescription to attain ≥99% TC values using the Novalis Tx platform. These plans were optimised mainly by leaf margin and/or collimator angle adjustment, while similar arc arrangements were used. Results TC values were equivalent among the three plans. Conformity index values were similar between the 80% and 70% plans, while they were worse in the 90% plans. Mean doses (Dmean) of the interior 3 mm rind structure were highest in the 70% plans, followed by the 80% plans and lowest in the 90% plans. Dmean of the exterior 3 mm rind structure and the ratio of 50%/100% isodose volumes (Paddick's gradient index values) were highest in the 90% plans, followed by 80% and lowest in the 70% plans. Conclusions These results suggest that the 70% IDS plans might be beneficial for both tumour control and reducing toxicity to surrounding normal tissue if appropriate dose conformity and precise treatment set-up are ensured. The 90% IDS plans are unfavourable in view of inferior dose gradient outside the target and should be limited to cases in which the target dose homogeneity is given the highest priority. PMID:22422384

  6. Clinical outcome of hypofractionated conventional conformation radiotherapy for patients with single and no more than three metastatic brain tumors, with noninvasive fixation of the skull without whole brain irradiation

    SciTech Connect

    Aoki, Masahiko . E-mail: maoki-rad@umin.ac.jp; Abe, Yoshinao; Hatayama, Yoshiomi; Kondo, Hidehiro; Basaki, Kiyoshi

    2006-02-01

    Purpose: To evaluate the efficacy and toxicity of hypofractionated conventional conformation radiotherapy (HCCRT) with noninvasive fixation of the skull on patients with single or several brain metastases. Methods and Materials: The subjects were 44 patients who had three or fewer brain metastases (26 solitary, 18 multiple). Treatment was conducted on 65 metastases by rotational conformal beam or multiple fixed coplanar beams with a standard linear accelerator. The planning target volume consisted of the tumor and a 1-cm safety margin. The median isocentric dose was 24 Gy (range, 18-30 Gy) in 3-5 fractions. Whole-brain irradiation was not applied as an initial treatment. Results: Actuarial local tumor control rates at 6 months and 1 year were 78.4% and 71.9%, respectively. In-field recurrence was noted in 10 of 65 tumors, and repeat HCCRT was applied in 5 tumors. Actuarial overall survival rates at 1 year, 2 years, and the median survival time were 50.8%, 24.1%, and 5.8 months, respectively. The patients with an active primary cancer and poor performance status had a poorer prognosis than those without those factors. Actuarial freedom from second brain metastases rates at 6 months, 1 year, and 2 years were 86.6%, 69.0%, and 40.9%, respectively. Second brain metastases were observed in 9 of 44 patients. Lung adenocarcinomas had a higher risk of second brain metastasis than others. Treatment-related severe early or late complications were not observed in this series. Conclusions: Hypofractionated conventional conformation radiotherapy achieved sufficient tumor control and survival. The results suggest that HCCRT would be one of the alternatives for patients with either solitary or several brain metastases.

  7. MR compatibility aspects of a silicon photomultiplier-based PET/RF insert with integrated digitisation.

    PubMed

    Weissler, Bjoern; Gebhardt, Pierre; Lerche, Christoph W; Wehner, Jakob; Solf, Torsten; Goldschmidt, Benjamin; Mackewn, Jane E; Marsden, Paul K; Kiessling, Fabian; Perkuhn, Michael; Heberling, Dirk; Schulz, Volkmar

    2014-09-01

    The combination of Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) into a single device is being considered a promising tool for molecular imaging as it combines the high sensitivity of PET with the functional and anatomical images of MRI. For highest performance, a scalable, MR compatible detector architecture with a small form factor is needed, targeting at excellent PET signal-to-noise ratios and time-of-flight information. Therefore it is desirable to use silicon photo multipliers and to digitize their signals directly in the detector modules inside the MRI bore. A preclinical PET/RF insert for clinical MRI scanner was built to demonstrate a new architecture and to study the interactions between the two modalities.The disturbance of the MRI's static magnetic field stays below 2 ppm peak-to-peak within a diameter of 56 mm (90 mm using standard automatic volume shimming). MRI SNR is decreased by 14%, RF artefacts (dotted lines) are only visible in sequences with very low SNR. Ghosting artefacts are visible to the eye in about 26% of the EPI images, severe ghosting only in 7.6%. Eddy-current related heating effects during long EPI sequences are noticeable but with low influence of 2% on the coincidences count rate. The time resolution of 2.5 ns, the energy resolution of 29.7% and the volumetric spatial resolution of 1.8 mm(3) in the PET isocentre stay unaffected during MRI operation. Phantom studies show no signs of other artefacts or distortion in both modalities. A living rat was simultaneously imaged after the injection with (18)F-Fluorodeoxyglucose (FDG) proving the in vivo capabilities of the system. PMID:25122591

  8. Commissioning and quality assurance of the Pinnacle(3) radiotherapy treatment planning system for external beam photons.

    PubMed

    Bedford, J L; Childs, P J; Nordmark Hansen, V; Mosleh-Shirazi, M A; Verhaegen, F; Warrington, A P

    2003-03-01

    The commissioning of a Pinnacle(3) treatment planning system is described. Four Elekta linear accelerators were commissioned for external beam photons. Measured data were used to derive parameter values for the Pinnacle(3) beam model by (1). fitting a Monte Carlo model of the accelerator head to measured data and then extracting the parameters for the Pinnacle(3) beam model, and by (2). using the auto-modelling facility within Pinnacle(3). Both of these methods yielded dose distributions in accord with published recommendations. A separate small-field beam model, customized for an in-house compact blocking system, was also created, which satisfied appropriate acceptance criteria for stereotactically guided conformal brain treatments. Inhomogeneous, oblique, asymmetrical and irregular fields were also assessed, with calculated and measured doses agreeing to within +/-3%. Dose-volume histogram calculation was found to be accurate to within +/-5% dose or volume for a grid size of 4 mm x 4 mm x 4 mm, with better accuracy being achieved for finer grids. Isocentric doses were compared between Pinnacle(3)'s collapsed cone convolution algorithm and the Bentley-Milan algorithm within the Target-2 treatment planning system. Dose differences were generally less than 3% in the dose prescribed, with larger values for breast plans, where the Pinnacle(3) algorithm calculated scatter more accurately. Pelvic and thoracic plans were also verified using an anthropomorphic phantom, with local dose differences between calculated and delivered dose of up to 8%, but mainly less than 3%, and with no systematic difference. Ionization chamber verifications using START and RT-01 trial procedures demonstrated differences between calculated and measured doses of less than 2%. Following satisfactory performance in the commissioning process, Pinnacle(3) has now been introduced into routine clinical use. PMID:12684232

  9. Conformal Locoregional Breast Irradiation with an Oblique Parasternal Photon Field Technique

    SciTech Connect

    Erven, Katrien; Petillion, Saskia; Weltens, Caroline; Van den Heuvel, Frank; Defraene, Gilles; Van Limbergen, Erik; Van den Bogaert, Walter

    2011-04-01

    We evaluated an isocentric technique for conformal irradiation of the breast, internal mammary, and medial supra-clavicular lymph nodes (IM-MS LN) using the oblique parasternal photon (OPP) technique. For 20 breast cancer patients, the OPP technique was compared with a conventional mixed-beam technique (2D) and a conformal partly wide tangential (PWT) technique, using dose-volume histogram analysis and normal tissue complication probabilities (NTCPs). The 3D techniques resulted in a better target coverage and homogeneity than did the 2D technique. The homogeneity index for the IM-MS PTV increased from 0.57 for 2D to 0.90 for PWT and 0.91 for OPP (both p < 0.001). The OPP technique was able to reduce the volume of heart receiving more than 30 Gy (V{sub 30}), the cardiac NTCP, and the volume of contralateral breast receiving 5 Gy (V{sub 5}) compared with the PWT plans (all p < 0.05). There is no significant difference in mean lung dose or lung NTCP between both 3D techniques. Compared with the PWT technique, the volume of lung receiving more than 20 Gy (V{sub 20}) was increased with the OPP technique, whereas the volume of lung receiving more than 40 Gy (V{sub 40}) was decreased (both p < 0.05). Compared with the PWT technique, the OPP technique can reduce doses to the contralateral breast and heart at the expense of an increased lung V{sub 20}.

  10. Startup of the Kling Center for Proton Therapy

    SciTech Connect

    Bloch, C.; Chen, K. L.; Klein, E. E.; Hill, P. M.; Saito, A.

    2013-04-19

    In November of 2011 Mevion Medical Systems (formerly Still River Systems) delivered the Mevion S250 proton therapy system accelerator to the Kling Center for Proton Therapy at the Siteman Cancer Center in Saint Louis. The Mevion system is unique, with an in-room gantry-mounted superconducting synchrocyclotron. This is the first true single-room proton therapy system and it has a greatly reduced size as well as cost. A month after its arrival, the installation was complete and the superconducting magnet was ramped up to full current ({approx}2000 amperes). In March of 2012, full energy beam (250 MeV) was extracted and radiation surveys were performed to verify the shielding. Once that was shown to be sufficient, Mevion began fine-tuning the system to provide a highly isocentric beam from the 50 ton system. In June of 2012 the field-shaping system (energy degraders, contoured scatterers and range modulators) were installed and measurements of the clinical beam properties commenced. Monte Carlo simulations (MCNPX) have been performed for the system and validated with beam measurements done at the factory. These simulations have been used for a preliminary commissioning of our treatment planning system. Additionally, predictions of the neutron background have been made and validated with factory measurements. Final commissioning of the treatment planning system and verification of the neutron background will be accomplished with measurements made later in 2012. Based on current progress, patient treatments are scheduled to begin in late 2012. Beam and radiation background data will be presented.

  11. TH-C-12A-05: Dynamic Couch Motion for Improvement of Radiation Therapy Trajectories in DCA and VMAT

    SciTech Connect

    MacDonald, L; Thomas, Christopher

    2014-06-15

    Purpose: To investigate the potential improvement in dosimetric external beam radiation therapy plan quality using an optimized dynamic gantry and couch motion trajectory which minimizes exposure to the organs at risk. Methods: Patient-specific anatomical information of head-and-neck and cranial cancer patients was used to quantify the geometric overlap between target volumes and organs-at-risk (OARs) based on their two-dimensional projection from source to a plane at isocentre as a function of gantry and couch angle. QUANTEC dose constraints were then used as weighting factors for the OARs to generate a map of couch-gantry coordinate space indicating degree of overlap at each point in space. A couch-gantry collision space was generated by direct measurement on a Varian Truebeam linac using an anthropomorphic solid-water phantom. A dynamic, fully customizable algorithm was written to generate a navigable ideal trajectory for the patient specific couch-gantry space. The advanced algorithm includes weighting factors which can be used to balance the implementation of absolute minimum values of overlap, with the clinical practicality of largescale couch motion and delivery time. Optimized trajectories were calculated for cranial DCA treatments and for head-and-neck VMAT treatments and compared to conventional DCA and VMAT treatment trajectories. Results: Comparison of optimized treatment trajectories with conventional treatment trajectories indicates a decrease in dose to the organs-at-risk between 4.64% and 6.82% (2.39 and 3.52 Gy) of the prescription dose per patient per organ at risk. Conclusion: Using simultaneous couch and gantry motion during radiation therapy to minimize the geometrical overlap in the beams-eye-view target volumes and the organs-at-risk can have an appreciable dose reduction to organs-at-risk.

  12. SU-F-BRE-07: Experimental Validation of a Lung SBRT Technique Using a Novel, True Volumetric Plenoptic-Plastic-Scintillator Detector

    SciTech Connect

    Goulet, M; Rilling, M; Gingras, L; Beaulieu, L; Archambault, L; Beddar, S

    2014-06-15

    Purpose: Lung SBRT is being used by an increasing number of clinics, including our center which recently treated its first patient. In order to validate this technique, the 3D dose distribution of the SBRT plan was measured using a previously developed 3D detector based on plenoptic camera and plastic scintillator technology. The excellent agreement between the detector measurement and the expected dose from the treatment planning system Pinnacle{sup 3} shows great promise and amply justify the development of the technique. Methods: The SBRT treatment comprised 8 non-coplanar 6MV photon fields with a mean field size of 12 cm{sup 2} at isocentre and a total prescription dose of 12Gy per fraction for a total of 48Gy. The 3D detector was composed of a 10×10×10 cm{sup 2} EJ-260 water-equivalent plastic scintillator embedded inside a truncated cylindrical acrylic phantom of 10cm radius. The scintillation light was recorded using a static R5 light-field camera and the 3D dose was reconstructed at a 2mm resolution in all 3 dimensions using an iterative backprojection algorithm. Results: The whole 3D dose distribution was recorded at a rate of one acquisition per second. The mean absolute dose difference between the detector and Pinnacle{sup 3} was 1.3% over the region with more than 10% of the maximum dose. 3D gamma tests performed over the same region yield passing rates of 98.8% and 96.6% with criteria of 3%/1mm and 2%/1mm, respectively. Conclusion: Experimental results showed that our beam modeling and treatment planning system calculation was adequate for the safe administration of small field/high dose techniques such as SBRT. Moreover, because of the real-time capability of the detector, further validation of small field rotational, dynamic or gated technique can be monitored or verified by this system.

  13. A 4 MV flattening filter-free beam: commissioning and application to conformal therapy and volumetric modulated arc therapy

    NASA Astrophysics Data System (ADS)

    Stevens, S. W.; Rosser, K. E.; Bedford, J. L.

    2011-07-01

    Recent studies have indicated that radiotherapy treatments undertaken on a flattening filter-free (FFF) linear accelerator have a number of advantages over treatments undertaken on a conventional linear accelerator. In addition, 4 MV photon beams may give improved isodose coverage for some treatment volumes at air/tissue interfaces, compared to when utilizing the clinical standard of 6 MV photons. In order to investigate these benefits, FFF beams were established on an Elekta Beam Modulator linear accelerator for 4 MV photons. Commissioning beam data were obtained for open and wedged fields. The measured data were then imported into a treatment planning system and a beam model was commissioned. The beam model was optimized to improve dose calculations at shallow, clinically relevant depths. Following verification, the beam model was utilized in a treatment planning study, including volumetric modulated arc therapy, for a selection of lung, breast/chest wall and larynx patients. Increased dose rates of around 800 MU min-1 were recorded for open fields (relative to 320 MU min-1 for filtered open fields) and reduced head scatter was inferred from output factor measurements. Good agreement between planned and delivered dose was observed in verification of treatment plans. The planning study indicated that with a FFF beam, equivalent (and in some cases improved) isodose profiles could be achieved for small lung and larynx treatment volumes relative to 4 MV filtered treatments. Furthermore, FFF treatments with wedges could be replicated using open fields together with an 'effective wedge' technique and isocentre shift. Clinical feasibility of a FFF beam was therefore demonstrated, with beam modelling, treatment planning and verification being successfully accomplished.

  14. Monte Carlo characterizations mapping of the (γ,n) and (n,γ) photonuclear reactions in the high energy X-ray radiation therapy

    PubMed Central

    Ghiasi, Hosein

    2013-01-01

    Aim The aim of this work was to map the characteristics of (n,γ) and (γ,n) reactions in a high energy photon radiation therapy. Background Photoneutrons produced in the high energy X-Ray radiation therapy may damage patients and staff. It is due to high RBE of the produced neutrons according to their energy and isotropic emission. Characterization of the photoneutrons can help us in appropriate shielding. Materials and methods This study focused on the photoneutron and capture gamma ray phenomena. Characteristics such as dose value, fluence and spectra of both the neutrons and the by produced prompt gamma ray were described. Results and discussion Neutron and prompt gamma spectra in different points showed the neutrons to be thermalized when increasing the distance from the linac. Energy of the neutrons changed from about 0.6 MeV at the isocentre to around 10−08 MeV at the outer door position. Although the neutrons were found as fast neutrons, their spectra showed they were thermal neutrons at the outer door position. Additionally, it was seen that the energy of the gamma rays is higher than the scattered X-ray energy. The energy of gamma rays was seen to be up to 10 MeV while the linac photons had energy lower than 1 MeV. Neutron source strength obtained in this work was in good agreement with the published data, which may be a confirmation of our simulation accuracy. Conclusion The study showed that the Monte Carlo simulation can be applied in the radiotherapy and industrial radiation works as a useful and precise estimator. We also concluded that the dose from the prompt gamma ray at the outer door location is higher than the scattered radiation from the linac and should be considered in the shielding. PMID:24936317

  15. SU-E-T-56: Brain Metastasis Treatment Plans for Contrast-Enhanced Synchrotron Radiation Therapy

    SciTech Connect

    Obeid, L; Adam, J; Tessier, A; Vautrin, M; Benkebil, M; Sihanath, R

    2014-06-01

    Purpose: Iodine-enhanced radiotherapy is an innovative treatment combining the selective accumulation of an iodinated contrast agent in brain tumors with irradiations using monochromatic medium energy x-rays. The aim of this study is to compare dynamic stereotactic arc-therapy and iodineenhanced SSRT. Methods: Five patients bearing brain metastasis received a standard helical 3D-scan without iodine. A second scan was acquired 13 min after an 80 g iodine infusion. Two SSRT treatment plans (with/without iodine) were performed for each patient using a dedicated Monte Carlo (MC) treatment planning system (TPS) based on the ISOgray TPS. Ten coplanar beams (6×6 cm2, shaped with collimator) were simulated. MC statistical error objective was less than 5% in the 50% isodose. The dynamic arc-therapy plan was achieved on the Iplan Brainlab TPS. The treatment plan validation criteria were fixed such that 100% of the prescribed dose is delivered at the beam isocentre and the 70% isodose contains the whole target volume. The comparison elements were the 70% isodose volume, the average and maximum doses delivered to organs at risk (OAR): brainstem, optical nerves, chiasma, eyes, skull bone and healthy brain parenchyma. Results: The stereotactic dynamic arc-therapy remains the best technique in terms of dose conformation. Iodine-enhanced SSRT presents similar performances to dynamic arc-therapy with increased brainstem and brain parenchyma sparing. One disadvantage of SSRT is the high dose to the skull bone. Iodine accumulation in metastasis may increase the dose by 20–30%, allowing a normal tissue sparing effect at constant prescribed dose. Treatment without any iodine enhancement (medium-energy stereotactic radiotherapy) is not relevant with degraded HDVs (brain, parenchyma and skull bone) comparing to stereotactic dynamic arc-therapy. Conclusion: Iodine-enhanced SSRT exhibits a good potential for brain metastasis treatment regarding the dose distribution and OAR criteria.

  16. The University of Texas M.D. Anderson Cancer Center Proton Therapy Facility

    SciTech Connect

    Smith, Alfred; Newhauser, Wayne; Latinkic, Mitchell; Hay, Amy; Cox, James; McMaken, Bruce; Styles, John

    2003-08-26

    The University of Texas M.D. Anderson Cancer Center (MDACC), in partnership with Sanders Morris Harris Inc., a Texas-based investment banking firm, and The Styles Company, a developer and manager of hospitals and healthcare facilities, is building a proton therapy facility near the MDACC main complex at the Texas Medical Center in Houston, Texas USA. The MDACC Proton Therapy Center will be a freestanding, investor-owned radiation oncology center offering state-of-the-art proton beam therapy. The facility will have four treatment rooms: three rooms will have rotating, isocentric gantries and the fourth treatment room will have capabilities for both large and small field (e.g. ocular melanoma) treatments using horizontal beam lines. There will be an additional horizontal beam room dedicated to physics research and development, radiation biology research, and outside users who wish to conduct experiments using proton beams. The first two gantries will each be initially equipped with a passive scattering nozzle while the third gantry will have a magnetically swept pencil beam scanning nozzle. The latter will include enhancements to the treatment control system that will allow for the delivery of proton intensity modulation treatments. The proton accelerator will be a 250 MeV zero-gradient synchrotron with a slow extraction system. The facility is expected to open for patient treatments in the autumn of 2005. It is anticipated that 675 patients will be treated during the first full year of operation, while full capacity, reached in the fifth year of operation, will be approximately 3,400 patients per year. Treatments will be given up to 2-shifts per day and 6 days per week.

  17. Poster — Thur Eve — 08: Rotational errors with on-board cone beam computed tomography

    SciTech Connect

    Ali, E. S. M.; Webb, R.; Nyiri, B.

    2014-08-15

    The focus of this study is on the Elekta XVI on-board cone beam computed tomography (CBCT) system. A rotational mismatch as large as 0.5° is observed between clockwise (CW) and counter-clockwise (CCW) CBCT scans. The error could affect non-isocentric treatments (e.g., lung SBRT and acoustic neuroma), as well as off-axis organs-at-risk. The error is caused by mislabeling of the projections with a lagging gantry angle, which is caused by the finite image acquisition time and delays in the imaging system. A 30 cm diameter cylindrical phantom with 5 mm diameter holes is used for the scanning. CW and CCW scans are acquired for five gantry speeds (360 to 120 deg./min.) on six linacs from three generations (MLCi, MLCi2, and Agility). Additional scans are acquired with different x-ray pulse widths for the same mAs. In the automated CBCT analysis (using ImageJ), the CW/CCW mismatch in a series of line profiles is identified and used to calculate the rotational error. Results are consistent among all linacs and indicate that the error varies linearly with gantry speed. The finite width of the x-ray pulses is a major but predictable contributor to the delay causing the error. For 40 ms pulses, the delay is 34 ± 1 ms. A simple solution applied in our clinic is adjusting the gantry angle offset to make the CCW one-minute scans correct. A more involved approach we are currently investigating includes adjustments of pulse width and mA, resulting in focal spot changes, with potential impact on image quality.

  18. Intensity-modulated radiation therapy and volumetric-modulated arc therapy for adult craniospinal irradiation—A comparison with traditional techniques

    SciTech Connect

    Studenski, Matthew T.; Shen, Xinglei; Yu, Yan; Xiao, Ying; Shi, Wenyin; Biswas, Tithi; Werner-Wasik, Maria; Harrison, Amy S.

    2013-04-01

    Craniospinal irradiation (CSI) poses a challenging planning process because of the complex target volume. Traditional 3D conformal CSI does not spare any critical organs, resulting in toxicity in patients. Here the dosimetric advantages of intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) are compared with classic conformal planning in adults for both cranial and spine fields to develop a clinically feasible technique that is both effective and efficient. Ten adult patients treated with CSI were retrospectively identified. For the cranial fields, 5-field IMRT and dual 356° VMAT arcs were compared with opposed lateral 3D conformal radiotherapy (3D-CRT) fields. For the spine fields, traditional posterior-anterior (PA) PA fields were compared with isocentric 5-field IMRT plans and single 200° VMAT arcs. Two adult patients have been treated using this IMRT technique to date and extensive quality assurance, especially for the junction regions, was performed. For the cranial fields, the IMRT technique had the highest planned target volume (PTV) maximum and was the least efficient, whereas the VMAT technique provided the greatest parotid sparing with better efficiency. 3D-CRT provided the most efficient delivery but with the highest parotid dose. For the spine fields, VMAT provided the best PTV coverage but had the highest mean dose to all organs at risk (OAR). 3D-CRT had the highest PTV and OAR maximum doses but was the most efficient. IMRT provides the greatest OAR sparing but the longest delivery time. For those patients with unresectable disease that can benefit from a higher, definitive dose, 3D-CRT–opposed laterals are the most clinically feasible technique for cranial fields and for spine fields. Although inefficient, the IMRT technique is the most clinically feasible because of the increased mean OAR dose with the VMAT technique. Quality assurance of the beams, especially the junction regions, is essential.

  19. Long-term stability and mechanical characteristics of kV digital imaging system for proton radiotherapy

    PubMed Central

    Zhu, Mingyao; Botticello, Thomas; Lu, Hsiao-Ming; Winey, Brian

    2014-01-01

    Purpose: To quantitatively evaluate the long-term image panel positioning stability and gantry angle dependence for gantry-mounted kV imaging systems. Methods: For patient setup digital imaging systems in isocentric rotating proton beam delivery facilities, physical crosshairs are commonly inserted into the snout to define the kV x-ray beam isocenter. Utilizing an automatic detection algorithm, the authors analyzed the crosshair center positions in 2744 patient setup kV images acquired with the four imagers in two treatment rooms from January 2012 to January 2013. The crosshair position was used as a surrogate for imaging panel position, and its long-term stability at the four cardinal angles and the panel flex dependency on gantry angle was investigated. Results: The standard deviation of the panel position distributions was within 0.32 mm (with the range of variation less than ± 1.4 mm) in both the X-Z plane and Y direction. The mean panel inplane rotations were not more than 0.51° for the four panels at the cardinal angles, with standard deviations ≤0.26°. The panel position variations with gantry rotation due to gravity (flex) were within ±4 mm, and were panel-specific. Conclusions: The authors demonstrated that the kV image panel positions in our proton treatment system were highly reproducible at the cardinal angles over 13 months and also that the panel positions can be correlated to gantry angles. This result indicates that the kV image panel positions are stable over time; the amount of panel sag is predictable during gantry rotation and the physical crosshair for kV imaging may eventually be removed, with the imaging beam isocenter position routinely verified by adequate quality assurance procedures and measurements. PMID:24694126

  20. Commissioning an Elekta Versa HD linear accelerator.

    PubMed

    Narayanasamy, Ganesh; Saenz, Daniel; Cruz, Wilbert; Ha, Chul S; Papanikolaou, Niko; Stathakis, Sotirios

    2016-01-01

    The purpose of this study is to report the dosimetric aspects of commissioning performed on an Elekta Versa HD linear accelerator (linac) with high-dose-rate flattening filter-free (FFF) photon modes and electron modes. Acceptance and commissioning was performed on the Elekta Versa HD linac with five photon energies (6 MV, 10 MV, 18 MV, 6 MV FFF, 10 MV FFF), four electron energies (6 MeV, 9MeV, 12 MeV, 15 MeV) and 160-leaf (5 mm wide) multileaf collimators (MLCs). Mechanical and dosimetric data were measured and evaluated. The measurements include percent depth doses (PDDs), in-plane and cross-plane profiles, head scatter factor (Sc), relative photon output factors (Scp), universal wedge transmission factor, MLC transmission factors, and electron cone factors. Gantry, collimator, and couch isocentricity measurements were within 1 mm, 0.7 mm, and 0.7 mm diameter, respectively. The PDDs of 6 MV FFF and 10 MV FFF beams show deeper dmax and steeper falloff with depth than the corresponding flattened beams. While flatness values of 6 MV FFF and 10 MV FFF normalized profiles were expectedly higher than the corresponding flattened beams, the symmetry values were almost identical. The cross-plane penumbra values were higher than the in-plane penumbra values for all the energies. The MLC transmission values were 0.5%, 0.6%, and 0.6% for 6 MV, 10 MV, and 18 MV photon beams, respectively. The electron PDDs, profiles, and cone factors agree well with the literature. The outcome of radiation treatment is directly related to the accuracy in the dose modeled in the treatment planning system, which is based on the commissioned data. Commissioning data provided us a valuable insight into the dosimetric characteristics of the beam. This set of commissioning data can provide comparison data to others performing Versa HD commissioning, thereby improving patient safety. PMID:26894351